text
stringlengths 174
850
| embeddings_A
sequence |
|---|---|
OBJECTIVE To describe the epidemiology of urban malaria, an emerging problem in sub-Saharan Africa. METHOD Cross-sectional surveys of communities in Accra and Kumasi, Ghana, determining risk factors for malaria infection and anaemia in children aged 6-60 months. RESULTS Malaria prevalence rates ranged from 2% to 33% between urban communities. 47.1% of children were anaemic (Hb<11.0 g/dl). Factors associated with malaria prevalence were low socio-economic status, age and anaemia. The attributable risks of anaemia and severe anaemia (Hb<8.0 g/dl) | [
0.02173674,
0.008214541,
0.017856568,
-0.03428565,
-0.012996623,
0.020205434,
-0.023358883,
0.0040099416,
-0.012626775,
-0.02808257,
-0.0035816955,
-0.0020601237,
0.021204676,
0.0036790243,
-0.009959969,
0.00753324,
0.040462777,
-0.01885581,
-0.009096988,
-0.0016010568,
-0.012127154,
0.01497564,
0.0098821055,
-0.010660735,
-0.007929043,
0.016325265,
0.02570775,
-0.031041361,
-0.007987441,
-0.012672194,
0.012860363,
-0.033948243,
-0.017648935,
-0.011718374,
-0.033273432,
0.0069103367,
0.011355013,
0.0008329713,
0.0070465966,
0.0019903716,
0.0022353155,
0.0016643205,
-0.0028549747,
0.007546217,
0.02529248,
0.017908478,
0.0013439469,
0.011069516,
-0.03013296,
0.015559612,
-0.015585566,
0.010024854,
-0.02104895,
0.020218411,
-0.014300828,
-0.0030577427,
-0.013898536,
0.00748782,
0.0029620363,
-0.0267589,
-0.0018930428,
0.005563956,
-0.033169616,
-0.025642864,
-0.02014055,
0.018687107,
-0.0013715234,
0.022139031,
0.0128992945,
0.010771041,
0.03337725,
0.03752994,
0.008746604,
-0.019971846,
0.008006906,
0.0089088185,
-0.005674262,
0.0070985053,
-0.015546635,
0.0074618654,
0.006884382,
0.017791683,
-0.030314641,
0.01903749,
0.015105411,
0.0036400927,
0.022489414,
0.021256585,
-0.001344758,
0.010972187,
-0.02117872,
0.01606572,
0.025266526,
0.013690901,
0.021386355,
0.008889353,
-0.01738939,
0.027641347,
0.024448965,
0.006199837,
-0.029016925,
0.009940503,
-0.0050610914,
-0.008071792,
-0.021996282,
0.009836686,
-0.014054262,
0.004314905,
0.0024056407,
-0.028394021,
0.0010065408,
0.034597103,
0.0044868523,
-0.029925326,
-0.005875408,
-0.025279503,
-0.00087920245,
0.0028549747,
0.009473325,
-0.008110723,
0.008000418,
0.00309343,
0.00753324,
-0.004918343,
0.0064626243,
0.002220716,
-0.04126736,
-0.024825303,
-0.009207293,
-0.02625279,
-0.020672612,
0.013093952,
0.02077643,
-0.0034259695,
-0.008792024,
0.013950445,
-0.039684147,
0.008363778,
-0.04035896,
-0.022203917,
0.001468041,
0.014158079,
0.0068908706,
-0.0148848,
0.018479472,
0.023462702,
0.03259862,
0.008331335,
-0.0067416336,
-0.008441641,
0.005729415,
-0.008052327,
0.017454278,
0.005826744,
0.0064853346,
-0.0017259619,
0.009388974,
0.021126812,
-0.034389466,
0.0061479285,
0.00048704894,
-0.010472566,
-0.00762408,
0.009856151,
-0.027823025,
0.013444335,
-0.015974881,
-0.004428455,
0.009324088,
-0.024968052,
-0.0073256055,
0.027563483,
-0.010076763,
0.011990894,
-0.00051178667,
0.011244707,
0.015767246,
0.01945276,
-0.025863476,
-0.0339742,
-0.025668819,
0.02761539,
0.012269903,
-0.006579419,
-0.007520263,
0.0111668445,
0.03228717,
0.0039969645,
0.022839798,
-0.0027414246,
0.017558094,
0.017311528,
-0.0019660394,
-0.0111668445,
-0.654464,
-0.0035070768,
-0.006615106,
0.008006906,
-0.010290886,
-0.014923731,
0.02808257,
-0.014729074,
-0.00730614,
0.036829174,
-0.006378273,
0.015053503,
-0.0030415214,
-0.03747803,
-0.005839721,
-0.026226835,
-0.022606209,
-0.0030090783,
0.017934432,
-0.026278744,
-0.014093193,
-0.011108447,
0.015767246,
0.009350042,
-0.0089088185,
0.01876497,
0.0121141765,
-0.041526906,
0.00040776664,
0.029094787,
-0.014482508,
0.035531458,
0.006628083,
0.03758185,
0.046042956,
-0.046042956,
-0.0054990705,
0.013132883,
0.016416105,
0.029068833,
-0.018453518,
-0.01831077,
0.0154557945,
-0.0023715755,
0.003271866,
0.018051226,
0.013574107,
-0.0032686216,
0.02543523,
0.0022677584,
-0.0017438056,
0.0076759886,
-0.01452144,
0.006199837,
0.011361501,
0.0039028802,
0.008487061,
-0.015572589,
0.0031664264,
-0.0048923884,
-0.031197088,
-0.024643622,
-0.020932155,
-0.017752752,
-0.0113160815,
0.028887153,
-0.003294576,
0.009946992,
-0.014274874,
-0.01807718,
0.012205017,
0.019803142,
-0.031145178,
0.0116275335,
0.024500873,
-0.012146619,
0.015845109,
0.012581354,
-0.039113153,
-0.0005787001,
0.0029863685,
0.015806178,
-0.0059630037,
0.0013699012,
0.028108524,
-0.020257343,
-0.020166503,
0.01264624,
0.007611103,
0.010725621,
0.015922973,
0.004392768,
-0.0024478163,
-0.00495403,
-0.008571412,
0.033532977,
-0.018557336,
0.006112241,
0.034181833,
-0.006365296,
-0.016403127,
-0.02123063,
0.010128671,
-0.023709267,
0.013230212,
0.016013812,
-0.03174213,
-0.012354254,
0.046717767,
-0.019634439,
-0.00029239157,
0.0047788383,
-0.0034584126,
-0.013807695,
0.023177203,
-0.022593232,
0.0072023226,
-0.00020297086,
0.012153109,
-0.016455036,
0.013768764,
0.02451385,
0.028549748,
-0.030184869,
-0.010115694,
0.009032101,
0.006521022,
-0.0037212,
0.0059889583,
-0.035220005,
-0.0054536504,
0.008013395,
0.03265053,
-0.0086103445,
0.06104455,
-0.020075662,
0.027978752,
-0.003260511,
0.004373302,
-0.029120741,
0.0012206639,
-0.01145883,
0.006456136,
-0.017960386,
-0.00009028249,
-0.025811566,
0.00044811747,
-0.017999317,
-0.021801624,
0.003250778,
-0.007890112,
-0.009752334,
-0.0039158575,
0.0074034682,
-0.01100463,
-0.010978675,
0.009317599,
-0.015118388,
-0.011653488,
0.009739357,
0.01356113,
0.019517645,
-0.017311528,
0.010407681,
-0.0071244594,
-0.0055444906,
-0.0032540222,
0.010394704,
0.0033708168,
-0.016701601,
-0.0013309697,
-0.030781819,
-0.016610762,
0.01871306,
0.027018443,
0.0045874254,
-0.008733627,
-0.016870305,
-0.03163831,
-0.0086103445,
0.005995447,
0.0029068834,
-0.020984065,
-0.011919519,
0.026032178,
0.0021785405,
0.021347424,
0.010693178,
0.023527587,
0.028653564,
0.0063717845,
0.032390986,
-0.032806255,
-0.00080985576,
-0.002914994,
-0.0029101276,
-0.0030982965,
0.021217654,
-0.018985583,
0.01738939,
0.02456576,
-0.0060927756,
0.0058948738,
-0.00091407856,
0.024020718,
-0.01383365,
-0.0024332171,
-0.0010706155,
0.023800107,
0.0070790397,
0.022333689,
-0.024461942,
0.005155176,
-0.0040650945,
-0.0061446843,
0.02382606,
-0.008441641,
-0.01264624,
-0.031171132,
-0.016364196,
0.0009546322,
0.0032345566,
0.01894665,
0.017324505,
-0.004214332,
0.00070117204,
0.009427905,
0.026629128,
0.0055412464,
-0.013496244,
-0.017869547,
-0.0039028802,
-0.007104994,
0.027693255,
0.006306899,
0.00963554,
-0.0059467824,
-0.029198606,
0.005200596,
0.009453859,
0.008603856,
0.014080216,
0.011218753,
0.008376755,
0.013243189,
-0.019829096,
0.013600062,
0.017765729,
0.014300828,
0.032936025,
0.00074415887,
0.008441641,
0.0006525077,
0.0017567828,
-0.013846627,
-0.007040108,
-0.0025889429,
0.0047139525,
0.022152008,
0.024968052,
0.02282682,
0.00158078,
-0.0034486796,
-0.010751575,
-0.007163391,
0.0016448548,
-0.009246225,
-0.006196593,
-0.009226759,
0.008214541,
-0.03345511,
-0.020426046,
0.026278744,
-0.015884042,
-0.006644305,
-0.0011249573,
-0.001524005,
-0.038023073,
0.022177963,
-0.00074253674,
-0.031430677,
0.0033107973,
0.00087920245,
0.03470092,
-0.0045874254,
-0.030729908,
0.006615106,
0.00935653,
-0.011069516,
0.010011877,
-0.00092462247,
0.022710025,
-0.020984065,
-0.034467332,
-0.02547416,
0.0044187224,
0.04235744,
0.00068251736,
0.0060895314,
-0.013178304,
-0.012763035,
-0.013113418,
-0.022632163,
0.013022577,
0.008785536,
0.013048532,
0.0051649087,
0.00972638,
-0.014326782,
0.009713403,
-0.008006906,
-0.038697883,
0.0052038403,
0.040748276,
-0.010784018,
0.01132257,
-0.011601579,
0.011887076,
0.021581013,
-0.015974881,
-0.002970147,
-0.014599303,
-0.01844054,
-0.0069038477,
0.06068119,
-0.0056775063,
-0.0024202398,
0.012827921,
0.029977234,
0.01798634,
0.0031907586,
-0.017597025,
0.01118631,
0.021762693,
-0.016701601,
-0.018726038,
0.013587084,
0.010829438,
0.015546635,
0.008091258,
-0.011705396,
-0.0138596045,
0.00084838166,
0.031404722,
0.01635122,
-0.0053303675,
0.018245883,
0.04835289,
0.017051985,
0.0014218099,
-0.0029101276,
0.009551188,
-0.0026619395,
-0.0116275335,
-0.0010268176,
-0.0034129925,
0.009434394,
0.017973363,
-0.0069427793,
0.009181339,
0.012853875,
-0.013366472,
0.010005388,
-0.0025694773,
0.027252031,
0.023852015,
-0.0016351219,
-0.00014832486,
0.015922973,
-0.0029198604,
0.0079614865,
0.00831187,
-0.0015004838,
-0.014677165,
0.04606891,
-0.008065304,
-0.0015085946,
-0.0073126284,
0.0135481525,
-0.0062744557,
0.004973496,
0.0040845606,
-0.001412077,
-0.0022336934,
-0.026629128,
-0.0019514401,
0.015300069,
0.008889353,
-0.022891706,
-0.008000418,
0.0042208205,
-0.0036692913,
-0.0315864,
-0.014326782,
-0.006728656,
-0.015780224,
0.0062841885,
0.005703461,
0.0053206347,
0.011601579,
0.026084088,
-0.01849245,
-0.00087271386,
0.01356113,
-0.03361084,
0.010907301,
0.01383365,
-0.0132237235,
0.011380968,
0.01593595,
0.025993247,
-0.014534417,
-0.016597785,
-0.013937468,
-0.022852775,
0.0016691869,
0.015339,
0.00295717,
-0.025461184,
-0.0034649011,
-0.0066637704,
0.019517645,
-0.030055096,
-0.02360545,
0.00036457702,
-0.028497837,
-0.007656523,
-0.0019676615,
0.0019757722,
-0.0036173826,
-0.029120741,
-0.0024169956,
-0.03747803,
-0.026655082,
0.003239423,
-0.023034455,
0.0174413,
0.014132124,
0.019569553,
0.010745087,
0.011011118,
0.009174851,
0.038983382,
-0.009752334,
-0.012289369,
0.0051162443,
0.011244707,
0.023112318,
-0.014625257,
0.019699326,
-0.0009546322,
-0.017220689,
-0.026123019,
-0.029743645,
0.010738598,
0.038100936,
0.011802725,
-0.013029066,
-0.010310352,
-0.011257684,
-0.011938985,
-0.021658877,
-0.0057813236,
-0.010835927,
-0.017830614,
-0.003174537,
-0.013340518,
-0.022813844,
0.024578737,
-0.026058132,
-0.006456136,
-0.016325265,
-0.016870305,
0.0011152244,
-0.010226,
0.004425211,
-0.0073580486,
-0.0013196147,
-0.032468848,
-0.017142825,
0.012458071,
-0.011919519,
0.03228717,
0.0017259619,
0.033169616,
0.008026372,
0.02392988,
0.000006136903,
-0.00035748014,
-0.006813008,
0.0030723421,
0.020218411,
-0.014300828,
0.022281779,
0.0071893455,
0.003484367,
-0.020789407,
-0.002566233,
0.017181756,
0.012905783,
-0.0101935575,
-0.029198606,
-0.0077603403,
-0.02730394,
-0.0060505997,
0.0076954546,
-0.012834409,
0.020737497,
-0.04638036,
-0.01812909,
0.04599105,
-0.0076046144,
0.0055088033,
-0.0154428175,
0.009181339,
0.002017948,
0.015144343,
-0.011024095,
0.0021834068,
0.022606209,
0.009661494,
-0.006634572,
-0.0013212368,
0.02173674,
0.0027884669,
0.0027073596,
0.0063036545,
-0.0050838017,
-0.0011249573,
0.016831374,
0.0009984301,
-0.019024514,
0.0038282615,
-0.009051568,
-0.014703119,
-0.0023164225,
-0.01356113,
-0.04007346,
-0.012516469,
0.026317677,
-0.0074424,
0.01854436,
-0.028056614,
-0.0049670073,
-0.007085528,
-0.015637474,
0.009058056,
-0.026655082,
0.022022236,
-0.0072672083,
-0.007066062,
-0.01639015,
0.0049118544,
0.011666465,
-0.01401533,
0.041371178,
0.017493209,
-0.027355848,
-0.0042921947,
0.027018443,
0.024461942,
0.0075267516,
-0.011374479,
0.037452076,
0.031560447,
-0.020374138,
-0.010809972,
-0.0024494384,
-0.028653564,
0.027978752,
0.005661285,
-0.016143585,
0.010122183,
-0.02411156,
-0.006501556,
0.030392503,
-0.028108524,
0.023579495,
-0.003977499,
-0.017739775,
0.009966457,
-0.021697808,
-0.00817561,
0.017428324,
0.006962245,
0.018726038,
0.004438188,
-0.0063588074,
0.0025710994,
-0.0048794113,
-0.0049605183,
0.01410617,
-0.0034389468,
0.030600138,
0.010725621,
-0.012445094,
0.020503908,
0.017752752,
-0.0006780565,
0.02862761,
-0.007520263,
-0.025954315,
-0.0013033933,
-0.019115353,
0.01219204,
0.023813084,
-0.016234424,
-0.007221788,
-0.023592472,
-0.008324847,
-0.003260511,
-0.026862716,
0.00885691,
-0.020919178,
-0.015546635,
-0.0148848,
-0.011530205,
0.021814601,
0.0024364614,
-0.0031307393,
-0.014067239,
0.0033773053,
-0.017856568,
0.0148328915,
0.047055174,
0.004889144,
-0.013846627,
0.008532481,
-0.015961904,
-0.0267589,
0.0076175914,
-0.014041285,
-0.034052063,
-0.0064431587,
-0.019413827,
0.025681796,
-0.024877211,
-0.026084088,
0.032339077,
0.020348184,
0.004295439,
-0.02424133,
-0.018349702,
0.05154527,
-0.027926844,
0.014962663,
0.0276673,
-0.013613039,
0.024435988,
-0.0063036545,
0.0019790165,
0.010972187,
-0.023138272,
-0.0022661362,
-0.012912272,
0.036958944,
-0.018453518,
-0.0008929907,
-0.011173333,
-0.009382485,
-0.011283639,
0.020452,
0.0058364766,
-0.0067091906,
-0.015624498,
-0.029613873,
-0.018622221,
-0.013230212,
0.00591434,
0.017999317,
0.01287334,
-0.019829096,
-0.02498103,
0.009032101,
-0.01903749,
0.047340672,
0.016455036,
-0.019893983,
-0.0018962872,
-0.017597025,
-0.054919332,
0.010005388,
0.0031420942,
0.017026031,
0.0005146254,
0.019738257,
0.022878729,
0.011646999,
0.00059127173,
0.019206194,
-0.034259696,
-0.0037503985,
0.010018365,
-0.008084769,
0.019374896,
-0.011932497,
-0.014222965,
0.002634363,
0.029561965,
-0.0114912735,
-0.0048404797,
0.033273432,
-0.004100782,
0.016169539,
-0.025500115,
0.014482508,
-0.018414587,
-0.035713136,
-0.006108997,
-0.013483267,
-0.01780466,
-0.0051616644,
0.009440882,
-0.0037049786,
-0.011984405,
0.00881149,
-0.024007741,
0.017311528,
-0.002499725,
-0.014482508,
0.015922973,
-0.043447524,
0.018518403,
-0.0018914207,
0.006897359,
0.005560712,
0.0060797986,
0.005907851,
0.0001785373,
0.01506648,
-0.010011877,
0.0036790243,
0.024371102,
0.009655005,
-0.004506318,
-0.0127500575,
-0.0061901044,
-0.0006354752,
0.0012693283,
-0.01383365,
-0.037685666,
-0.01018058,
0.009797754,
0.004337615,
0.000543824,
-0.0052492605,
0.014495485,
-0.016701601,
-0.004687998,
0.0024916143,
0.0072152996,
-0.008882864,
0.010790506,
-0.00045501158,
-0.004619868,
0.013171815,
0.0020747231,
0.004506318,
-0.03036655,
0.0050805574,
0.18489854,
-0.008662253,
0.007967975,
0.0053044134,
-0.009135919,
0.0019254858,
0.031794038,
-0.0062614786,
-0.00038688153,
0.028368067,
0.009330576,
-0.004117003,
-0.0046587996,
0.007117971,
-0.01812909,
-0.0069427793,
-0.0369849,
-0.0013974777,
-0.007831715,
-0.0047463956,
-0.0074683544,
0.0028095546,
-0.025448207,
-0.00518113,
0.011569136,
0.014742051,
-0.010660735,
0.023229113,
0.028238295,
0.0033545953,
0.010297375,
0.007513774,
0.002691138,
0.013885559,
-0.0111668445,
-0.005369299,
0.006180371,
-0.011796236,
0.005972737,
0.024500873,
-0.016948167,
0.011971428,
-0.022139031,
0.018103136,
-0.017064963,
0.018064203,
0.0013374583,
-0.01228288,
-0.01606572,
-0.0020455245,
-0.021697808,
-0.03355893,
-0.009045079,
0.008182098,
-0.024591714,
0.000728343,
0.021866512,
0.014391668,
-0.00076403015,
0.0072282767,
0.008805001,
0.017129848,
-0.009538211,
0.029613873,
-0.0024007743,
0.041760493,
-0.023488656,
-0.00634583,
-0.01036226,
-0.007792783,
-0.0030431435,
-0.013269144,
-0.013327541,
0.010933256,
-0.00365307,
-0.0036757798,
0.022385597,
0.0041526905,
0.011887076,
-0.00021716462,
-0.024721485,
-0.011575624,
-0.014651211,
0.007779806,
-0.003419481,
-0.041085683,
0.006702702,
0.03236503,
-0.028731426,
-0.0073515596,
-0.0021785405,
0.0071439254,
0.0017648934,
-0.025785612,
-0.010102717,
0.007916066,
0.01328861,
0.007066062,
-0.0012498625,
-0.01738939,
-0.027096305,
0.07023238,
-0.00318427,
-0.0042889505,
-0.0005588289,
0.0098821055,
-0.026382562,
0.009609586,
-0.011121424,
0.012912272,
0.016597785,
-0.04113759,
0.004538761,
-0.02059475,
0.026992489,
0.02132147,
0.0044900966,
-0.022022236,
0.0116275335,
-0.006199837,
-0.020283297,
-0.025097823,
0.0027106039,
0.02392988,
-0.016649693,
-0.031223042,
-0.02342377,
-0.0017308284,
0.004775594,
-0.030781819,
0.025006983,
-0.024202399,
-0.009817219,
0.013457312,
-0.016169539,
0.017051985,
-0.018687107,
0.00067846203,
0.01606572,
0.004201355,
0.016896259,
-0.03638795,
0.02333293,
-0.0070725507,
-0.018168021,
-0.013716856,
0.0109916525,
0.013314564,
-0.02204819,
0.008104235,
-0.0071309484,
-0.016182516,
0.0069752224,
-0.022424528,
0.026992489,
-0.02862761,
0.0042986833,
-0.013418381,
0.010621804,
0.0010203291,
-0.010965698,
0.021671854,
0.025720727,
-0.008383244,
0.014988617,
0.03615436,
-0.16288929,
0.015468772,
0.012529446,
-0.015909996,
0.013022577,
0.0017794927,
0.0135481525,
-0.0012709504,
-0.0103427945,
-0.030081052,
0.031041361,
0.0037082229,
-0.033117708,
-0.0023018233,
-0.0000492473,
0.0013131262,
-0.019790165,
0.030574184,
0.03470092,
0.0020147038,
0.03150854,
-0.010115694,
0.006488579,
0.0009448993,
-0.006086287,
0.017999317,
-0.017882524,
0.018816879,
-0.021282539,
-0.01620847,
-0.023164226,
-0.010576383,
0.022385597,
-0.017103894,
0.0003451113,
-0.0040553617,
-0.010952721,
0.01356113,
-0.0013050154,
-0.0100313425,
0.019361919,
0.0070011765,
0.0037503985,
0.016870305,
0.013989376,
0.030729908,
0.011621045,
0.0016659426,
0.020932155,
0.006780565,
0.0073385825,
0.00762408,
0.028549748,
0.003779597,
-0.0015653697,
-0.006501556,
-0.0012182307,
0.00890233,
0.030262731,
-0.0008126945,
-0.010238977,
-0.025123777,
0.011880588,
-0.00029644693,
0.01401533,
-0.028783336,
-0.011958451,
0.023086363,
-0.005356322,
0.013664947,
-0.03387038,
-0.0074943085,
-0.0030090783,
-0.02411156,
0.019154284,
0.02498103,
-0.013522198,
0.013574107,
-0.010894324,
-0.008649276,
-0.015624498,
0.009019124,
-0.025331412,
0.02483828,
-0.011744328,
-0.0010795373,
0.002095811,
0.005239527,
-0.015468772,
-0.010226,
0.014430599,
-0.042020038,
0.0029944791,
-0.024280261,
0.025032938,
0.011160356,
-0.006488579,
-0.00486319,
0.015196252,
-0.0013609794,
0.03236503,
-0.01844054,
-0.04292844,
-0.009934015,
0.034908555,
-0.0086103445,
0.012905783,
-0.0021542083,
0.03651772,
-0.006199837,
-0.015274115,
-0.010388215,
0.003620627,
0.0055672005,
0.004246775,
0.020101618,
0.0297696,
-0.021010019,
-0.0009270557,
-0.0058234995,
0.029743645,
-0.018933672,
-0.0034908555,
0.016104653,
-0.016130608,
-0.006410716,
-0.11419899,
0.03049632,
0.0041526905,
-0.017194733,
0.014716097,
-0.001165511,
-0.015819155,
-0.0038477273,
0.013626016,
0.020218411,
-0.054452155,
-0.004798304,
-0.0037276885,
-0.0045030736,
0.056580406,
0.0008800135,
0.008869887,
-0.009045079,
-0.026940579,
0.03524596,
-0.007241254,
0.003172915,
0.00522655,
0.0043343706,
-0.0050805574,
-0.0016537765,
-0.0089088185,
-0.0012814943,
0.0042208205,
0.035946727,
0.019439783,
-0.015585566,
0.009311111,
-0.017519163,
-0.0069362908,
-0.013976399,
-0.010323329,
-0.010505009,
0.007630569,
-0.034181833,
-0.008817978,
0.019958869,
0.04113759,
-0.013781741,
0.026226835,
-0.0064528915,
-0.022930637,
-0.006728656,
0.019699326,
-0.030392503,
-0.0017470499,
-0.010861881,
-0.012490515,
-0.026732944,
-0.0012003871,
-0.008396221,
-0.02319018,
0.023384837,
0.0017811148,
-0.004172156,
0.002431595,
-0.0018962872,
-0.00963554,
0.019089399,
0.024202399,
-0.0055444906,
-0.019465737,
-0.008104235,
0.0037503985,
-0.031794038,
-0.020205434,
0.009103476,
-0.0038963915,
-0.015403886,
-0.022930637,
0.007611103,
-0.002478637,
-0.001636744,
0.0013609794,
-0.002206117,
-0.011380968,
-0.014054262,
-0.00011010307,
-0.008746604,
0.010933256,
0.032313123,
0.0002262892,
-0.009888594,
0.013353495,
-0.008753093,
0.011471807,
0.023800107,
0.013301587,
-0.01735046,
0.022035213,
0.021334447,
-0.0011865989,
-0.02306041,
0.018168021,
-0.010712644,
-0.033117708,
-0.031560447,
-0.059020113,
0.010174092,
0.035635274,
-0.0039288346,
-0.014054262,
0.002499725,
0.01840161,
-0.007332094,
0.004496585,
-0.0033837939,
0.0037309327,
0.004496585,
-0.037867345,
0.0017567828,
-0.012458071,
0.0025938093,
-0.00087271386,
0.032105487,
0.031171132,
0.016792443,
-0.018466495,
0.01985505,
-0.009181339,
0.03511619,
-0.010654246,
0.003756887,
0.0046004024,
0.028835244,
-0.023813084,
0.017700844,
0.01876497,
-0.031534493,
-0.002936082,
-0.0065631974,
0.0014412756,
-0.03355893,
0.024643622,
0.008662253,
0.027563483,
0.042798664,
-0.013794718,
0.018751992,
0.012010359,
-0.02017948,
-0.0068649165,
-0.006514533,
0.0037893301,
0.024332171,
0.004022919,
-0.01548175,
0.047288764,
0.0019692837,
-0.003533031,
-0.028731426,
-0.021425288,
-0.0036595585,
-0.00497674,
0.016169539,
0.01972528,
-0.022126054,
0.021684831,
-0.007630569,
-0.0122504365,
0.006517777,
0.009259202,
-0.047366627,
-0.0246566,
0.010433635,
0.006602129,
-0.0390872,
-0.0019692837,
-0.022865752,
-0.003172915,
0.0063620517,
-0.020529864,
0.007753852,
0.00014781793,
0.022126054,
0.007831715,
0.025876453,
0.0025029692,
0.0049410528,
-0.03584291,
0.031560447,
0.026071109,
0.00055801775,
-0.01036226,
0.010264932,
-0.03303984,
0.006605373,
-0.025214618,
0.023047432,
-0.01291876,
-0.0074813315,
-0.024474919,
0.013703878,
0.0127825,
-0.0020374137,
0.031482585,
0.034363512,
-0.010063786,
-0.0048015486,
-0.005515292,
-0.035739094,
-0.009369507,
-0.0013755787,
-0.014482508,
-0.034337558,
0.002837131,
0.009713403,
0.00862981,
0.022385597,
-0.005502315,
-0.010057298,
0.0038282615,
-0.0074229343,
-0.00495403,
0.024215376,
-0.02574668,
0.0103557715,
-0.0098821055,
0.025824543,
-0.00926569,
-0.013275633,
0.017285574,
-0.0028127988,
0.00017610409,
0.002645718,
0.029639829,
-0.01981612,
-0.0048112813,
0.010608827,
-0.035791002,
-0.010693178,
0.005336856,
-0.02237262,
0.033481065,
0.0051065115,
0.023138272,
0.055853687,
-0.020023754,
-0.022320712,
-0.008376755,
0.0034389468,
0.021568036,
0.011958451,
0.0057002166,
0.0003309175,
-0.025539046,
0.008941262,
-0.0039126133,
0.013846627,
-0.040436823,
-0.043343708,
0.019932915,
-0.012594331,
0.012386697,
-0.017597025,
0.006167394,
0.022774912,
0.004798304,
0.02688867,
0.017584048,
-0.023527587,
-0.0055672005,
0.031845946,
0.0049475413,
-0.0127825,
-0.028134478,
-0.01958253,
0.0026814053,
-0.008162633,
-0.02291766,
0.0070595737,
-0.015559612,
-0.0021996282,
-0.037270397,
0.029484103,
0.0034097482,
0.0028192876,
0.005661285,
-0.020114595,
-0.0117897475,
-0.02278789,
-0.028160432,
-0.027952798,
-0.024877211,
-0.010492032
] |
CONTEXT Delayed cerebral vasospasm causes permanent neurological deficits or death in at least 15% of patients following otherwise successful treatment for ruptured intracranial aneurysm. Decreased bioavailability of nitric oxide has been associated with the development of cerebral vasospasm. OBJECTIVE To determine whether infusions of nitrite will prevent delayed cerebral vasospasm. DESIGN, SETTING, AND SUBJECTS A total of 14 anesthetized cynomolgus monkeys had an autologous blood clot placed around the right middle cerebral artery. Cerebral arteriography was performed before clot placement and on days 7 | [
-0.03180722,
-0.0019220804,
0.027037488,
-0.015849562,
-0.027402313,
0.018376304,
-0.006894492,
-0.008276093,
-0.04118454,
-0.011052807,
-0.004489358,
0.025713313,
0.009154372,
0.0273888,
-0.0072964737,
0.0032648342,
0.0323477,
0.00944488,
0.028483272,
-0.022146149,
0.0001687943,
0.025051227,
-0.014025444,
-0.006154711,
0.0006781329,
-0.005654767,
-0.015457715,
-0.025848433,
-0.006958674,
-0.010883907,
-0.014241636,
-0.00903952,
-0.00797883,
-0.014457827,
-0.002330818,
-0.00794505,
-0.01393086,
0.008627404,
0.002570656,
-0.0015741467,
0.017389929,
0.0007756726,
-0.00056243653,
0.005779753,
-0.03296925,
-0.00693165,
-0.019551847,
-0.008951693,
-0.026672665,
0.01199189,
0.040319774,
-0.0038306487,
0.002148406,
0.01868708,
0.00016984993,
-0.039995488,
-0.015065867,
0.013295797,
0.010329915,
-0.020281496,
0.0075802254,
0.0050669955,
-0.00716811,
0.015498251,
-0.035023075,
-0.009559732,
0.002536876,
0.007985585,
0.005158202,
0.008444993,
0.045562424,
0.03188829,
-0.010552863,
-0.0006485754,
0.027375288,
0.0020301763,
-0.03745523,
-0.0130323125,
-0.0039117206,
0.0077761495,
0.021457037,
-0.025794387,
-0.030077687,
0.02921292,
0.033888068,
-0.016957546,
0.006637764,
0.012660733,
-0.022402877,
0.0010615356,
0.021240845,
0.023483837,
-0.005887849,
-0.0014956082,
0.008647673,
0.020835487,
-0.0039759027,
0.007377546,
-0.0071951337,
-0.012228349,
0.009688096,
-0.027699577,
-0.030888407,
-0.021929957,
0.002271703,
0.010958223,
-0.015200987,
0.0028797425,
0.022159662,
-0.002396689,
-0.0066174963,
0.030293878,
-0.020984119,
-0.022173174,
-0.01192433,
0.010181284,
0.023064965,
-0.012539125,
0.0073707895,
-0.020916559,
-0.00435086,
-0.009390832,
0.030969478,
-0.028591368,
0.014255148,
0.015565811,
-0.013228237,
-0.0042833006,
0.0027868475,
-0.008620649,
-0.022943357,
0.017795289,
0.014944259,
-0.024889084,
-0.010390719,
0.025659267,
-0.03540141,
-0.002324062,
-0.028429223,
-0.027023977,
0.0051480676,
0.02357842,
-0.026807785,
0.008100437,
-0.017525049,
0.025591707,
0.017903386,
0.023889195,
0.004972412,
-0.0037529548,
-0.0033898202,
-0.029753398,
-0.0010167771,
-0.03588784,
-0.021119239,
0.021294894,
-0.0020808463,
0.021497574,
0.024429675,
-0.0005995945,
-0.0041718264,
-0.010161015,
0.007120818,
-0.010106968,
-0.0015918812,
0.00699921,
-0.015052355,
-0.02813196,
0.0005476578,
-0.010025895,
-0.023605444,
0.049372807,
-0.007857221,
0.019484287,
0.010181284,
0.015187475,
0.026456473,
0.026064625,
0.005019704,
-0.030942453,
-0.027213145,
0.003590811,
0.009046276,
0.023902709,
-0.008363921,
0.0078031733,
0.0568044,
-0.013174189,
0.01720076,
-0.010329915,
-0.000585238,
0.0092692245,
-0.025605218,
-0.023632469,
-0.6338744,
-0.021240845,
0.012099986,
-0.0013520434,
0.01609278,
0.023835149,
-0.0016746421,
-0.0009838417,
-0.009248956,
0.032131508,
-0.00030908672,
0.03526629,
0.0011611865,
-0.0076207616,
-0.0132012125,
-0.008823329,
-0.0005333013,
0.016808914,
0.017916897,
-0.011397363,
0.024929618,
0.008215289,
-0.0019507933,
0.0074180816,
0.019389704,
0.012944485,
0.017065642,
-0.013025557,
-0.03242877,
0.002621326,
0.025294442,
0.02894268,
0.00043533937,
0.012924217,
0.052615684,
-0.020173399,
-0.0044792243,
0.0008825018,
-0.020443639,
0.025767362,
-0.03553653,
0.002263258,
0.020821974,
-0.010039408,
-0.008208533,
0.015471227,
0.0032935473,
-0.026280819,
-0.01595766,
0.0009348607,
0.02147055,
-0.006806664,
-0.018714104,
0.023551395,
0.00048854284,
-0.014038956,
0.024483724,
-0.004712306,
-0.000289241,
0.008816573,
-0.017241297,
-0.011329803,
-0.01205945,
-0.030158758,
0.00880306,
0.028618392,
-0.023591932,
0.002386555,
0.017714217,
-0.0017954055,
0.020281496,
0.026037602,
0.011052807,
-0.036536418,
0.024145924,
0.013349845,
0.011073074,
0.023051452,
-0.014836163,
0.0020149753,
-0.024740452,
-0.003607701,
-0.004681904,
0.012775585,
0.026524033,
0.014795627,
-0.019105952,
0.006276319,
-0.0028206275,
-0.019187024,
0.0007807396,
0.002217655,
-0.007208646,
-0.030753287,
-0.013545768,
0.031618055,
0.028726488,
-0.00006782385,
0.009127349,
0.0025301198,
-0.0181466,
-0.00699921,
-0.02167323,
-0.016552186,
-0.0014660507,
0.0017937165,
-0.031861268,
-0.022213709,
0.030483047,
-0.021821862,
0.0088976445,
-0.0014677398,
0.0113365585,
-0.031320788,
-0.0028679196,
-0.01916,
-0.0029152115,
-0.00013934239,
-0.0038374048,
-0.02921292,
-0.019376192,
-0.0014533832,
0.003705663,
-0.013106629,
0.0063844146,
0.014430804,
-0.012566149,
-0.005756107,
-0.027888745,
-0.03521224,
0.0036820169,
0.020713879,
0.026591593,
0.00057510403,
0.017754752,
-0.004746086,
0.03051007,
0.0066445204,
-0.022389365,
-0.025605218,
0.0003223876,
0.009829972,
-0.008472017,
0.0055804513,
-0.0076545416,
-0.0057662413,
-0.0138633,
0.01603873,
-0.013329577,
-0.0062965867,
0.0184844,
-0.0075937374,
-0.0027851586,
0.028104937,
0.013944373,
-0.0135727925,
-0.01630897,
-0.016633257,
-0.020957094,
-0.005948653,
0.013309308,
0.0021416503,
-0.013890324,
0.017768266,
-0.025875458,
-0.029321015,
0.014971283,
-0.0005248563,
-0.013613328,
-0.026794273,
-0.0045670522,
-0.02038959,
0.0049251197,
0.015525275,
-0.031861268,
0.024159435,
-0.008235557,
-0.00706677,
-0.0039083427,
0.020578759,
-0.007965317,
-0.03921179,
0.014849676,
0.00232744,
0.042103358,
0.020349056,
0.012660733,
0.017160226,
-0.0008757458,
0.02514581,
0.0057358393,
0.01399842,
-0.041400734,
-0.009998872,
-0.014863187,
-0.0031550494,
0.0015192542,
-0.0029489915,
-0.0036853948,
0.029942567,
0.04513004,
-0.0026719957,
0.020173399,
0.006012835,
0.010525839,
-0.0050298376,
0.009505684,
0.006154711,
0.029645303,
-0.014120028,
-0.0025858567,
0.027280705,
-0.015255035,
-0.0042866785,
0.002373043,
0.0037191748,
-0.0022733922,
-0.009559732,
0.012241862,
-0.0034252892,
0.004786622,
-0.0154036665,
0.018403329,
0.014214612,
-0.026240282,
0.028213032,
0.010154259,
0.012140522,
0.00018220072,
-0.035293315,
-0.008330141,
0.017781777,
0.005019704,
-0.0051784697,
0.016363017,
0.026240282,
0.0026719957,
-0.010485304,
0.030158758,
0.026537545,
0.0029861494,
0.005887849,
0.04077918,
-0.012106742,
0.009965092,
0.014106516,
0.038644288,
0.031482935,
0.005847313,
0.029023752,
0.009458392,
-0.0024726938,
-0.017700706,
-0.021794837,
-0.021970494,
0.010140748,
0.016633257,
0.010228575,
0.03194234,
0.01447134,
0.044832777,
0.012708025,
0.015727954,
-0.008985473,
0.019011367,
0.0007144464,
0.011127123,
0.012471565,
0.016619746,
-0.017471,
-0.021713765,
-0.015782002,
-0.009607024,
-0.022335317,
0.0154036665,
0.009985359,
-0.010066431,
0.01807904,
0.026686177,
0.0028560965,
-0.0077423695,
-0.03704987,
0.02106519,
0.020295007,
0.003318882,
-0.0093705645,
0.016592722,
0.0142011,
0.0037461987,
0.031618055,
0.006208759,
0.0046177222,
0.0027851586,
0.0134038925,
0.0052054934,
-0.021659717,
0.034104258,
-0.003516495,
0.0041650706,
-0.037671424,
0.004610966,
0.018403329,
-0.017984457,
-0.0052156276,
0.008039633,
0.030888407,
0.0011079831,
-0.010492059,
-0.003489471,
0.015592835,
0.017011594,
-0.020213936,
-0.0009010807,
0.00713433,
0.021078702,
0.009688096,
-0.028591368,
-0.0054554655,
0.017173737,
0.0007406259,
-0.003712419,
-0.022889309,
0.0041819606,
-0.034374498,
0.03364485,
0.012613441,
-0.007053258,
0.015187475,
0.012674245,
-0.017173737,
-0.0135390125,
-0.00071149063,
0.029996615,
-0.014741579,
0.024902595,
0.006654654,
0.011877038,
0.00910708,
0.028699463,
0.03894155,
0.0061276867,
-0.009363808,
-0.0020521332,
-0.011701382,
0.0044285543,
0.0006764439,
0.02432158,
0.034942,
0.0062628067,
-0.012687758,
0.010323159,
0.022659605,
0.011431143,
0.0077288575,
-0.0042562764,
0.021902934,
-0.0054520876,
0.02759148,
-0.015930634,
-0.028780535,
0.009884019,
0.014241636,
0.012106742,
0.02880756,
0.005039972,
0.029834472,
-0.0068843584,
0.009384076,
0.0003717908,
-0.03813083,
0.018835712,
-0.002324062,
-0.014484852,
-0.012505345,
0.031428885,
-0.00068362214,
-0.010228575,
-0.017173737,
0.022024542,
0.011424386,
-0.000058851045,
-0.00081198604,
-0.0020707122,
0.012431029,
-0.008127461,
-0.021186799,
0.014457827,
-0.012390493,
-0.027550945,
-0.025915993,
-0.029158872,
-0.00934354,
-0.019214047,
0.009194909,
0.015498251,
0.017052129,
-0.034023188,
0.03194234,
0.01165409,
0.0013976463,
0.018119577,
-0.024010804,
-0.013971396,
0.02561873,
-0.02357842,
-0.03418533,
-0.0036651269,
-0.016498137,
0.012998533,
0.0030030394,
0.0054419534,
-0.013410648,
-0.0055838292,
-0.009863752,
0.029564232,
-0.0063641467,
0.015011819,
-0.015255035,
0.02072739,
-0.004985924,
0.004793378,
0.01582254,
-0.018173624,
-0.008526064,
0.019187024,
-0.037671424,
-0.0064350846,
-0.03137484,
-0.016673794,
-0.0007896068,
-0.0041245343,
0.0052865655,
0.027023977,
-0.0074045695,
0.023740564,
0.0011358515,
-0.010694739,
-0.008681453,
0.012626953,
0.019524824,
-0.004833914,
0.038157854,
0.0004627856,
0.013113385,
-0.0053439913,
0.014903723,
0.021092214,
0.0027057757,
-0.0064756204,
0.018714104,
0.023740564,
-0.010910931,
-0.019727504,
0.021659717,
-0.00021112482,
0.044319324,
0.015538787,
-0.030131735,
-0.03732011,
-0.017957432,
0.00061437325,
-0.015552299,
-0.010471791,
-0.003600945,
-0.0016037042,
0.007053258,
-0.022875797,
0.0076612975,
0.050642934,
-0.018160112,
-0.0020859132,
-0.034158308,
-0.020092327,
-0.000075477124,
-0.014998307,
-0.00804639,
-0.029239943,
-0.0056649013,
-0.014890212,
-0.04864316,
-0.0027632017,
-0.022997405,
0.025321467,
0.013586304,
0.023362229,
-0.008944936,
0.00058734923,
0.025334978,
0.01393086,
0.026321353,
0.0017835825,
0.0091341045,
-0.015863074,
0.040725134,
-0.00797883,
-0.0042866785,
0.008546333,
-0.02853732,
0.028915655,
0.018024992,
-0.023875684,
-0.02921292,
-0.000010384702,
-0.04899447,
0.006722214,
0.022551509,
-0.009424612,
-0.008593624,
-0.03942798,
-0.013626841,
0.017727729,
0.0019693724,
-0.002484517,
-0.012005402,
0.0066242525,
0.0025301198,
0.008059901,
-0.011937842,
0.028726488,
0.011904062,
-0.00480689,
0.0033323942,
-0.011647334,
0.004675148,
0.0062188925,
0.004729196,
0.014876699,
-0.00091121474,
-0.034509618,
0.021389479,
-0.0032445663,
0.0069721863,
0.010039408,
-0.010485304,
-0.0093030045,
0.00077778386,
-0.022713652,
-0.00062957424,
-0.004610966,
0.011532483,
-0.009120592,
0.021092214,
-0.050129477,
-0.003604323,
-0.0018646545,
-0.037671424,
0.010133991,
-0.021970494,
0.043940987,
0.007546446,
-0.014836163,
0.0039961706,
0.0017970945,
0.008694964,
-0.00097539666,
0.009958335,
0.022159662,
-0.010681227,
-0.013039069,
-0.0064148167,
0.035563555,
-0.011431143,
-0.03704987,
0.047535177,
-0.0037597108,
-0.0018578984,
-0.008708477,
-0.029591255,
-0.01570093,
0.020430127,
-0.016957546,
-0.020903047,
0.011998646,
-0.020646319,
-0.013059337,
0.017173737,
-0.019727504,
0.029699352,
0.005759485,
0.011512214,
-0.018335769,
0.014579436,
-0.014660507,
-0.00086898974,
0.010032652,
0.019970719,
0.0012954619,
-0.0032952363,
-0.009809704,
0.011762186,
0.001185677,
-0.012755318,
-0.008053145,
0.037806544,
-0.0077558816,
-0.0058709593,
0.020430127,
-0.0026888857,
0.0002968415,
-0.034914978,
-0.008674697,
-0.038860478,
-0.0076477854,
0.0011797654,
0.02303794,
0.017727729,
-0.022375854,
-0.008053145,
-0.016903497,
-0.020808462,
0.00450287,
-0.0142011,
0.0020183532,
-0.04234657,
-0.021281382,
-0.00007062125,
-0.009802948,
0.0074856416,
-0.007377546,
-0.0012287465,
-0.0004032484,
-0.0033340831,
-0.0025672778,
0.008316629,
0.009147616,
0.030699238,
-0.017849337,
0.00917464,
-0.0116743585,
-0.026888857,
0.021727277,
0.01610629,
-0.051048294,
0.0067120804,
0.0019795063,
-0.017700706,
-0.006174979,
-0.019565359,
0.027132073,
-0.017295346,
-0.007215402,
-0.006242539,
-0.033888068,
0.028348152,
-0.014498364,
0.008586869,
0.020889534,
-0.036401298,
-0.025605218,
-0.012356713,
0.024821524,
0.020916559,
-0.020835487,
-0.018700592,
-0.022348829,
0.010336671,
-0.018173624,
-0.015430691,
-0.002349397,
-0.033834018,
-0.0237811,
-0.008911156,
-0.0041312906,
-0.007147842,
-0.012829633,
0.010735275,
-0.015309083,
-0.014728067,
-0.010431255,
0.007823441,
0.012728293,
-0.026064625,
-0.024591818,
0.0069181384,
-0.030888407,
0.011174414,
0.008492284,
0.010025895,
-0.018497912,
-0.00961378,
-0.051345557,
0.0010682916,
-0.012539125,
0.03215853,
0.045778617,
0.021767814,
0.009357052,
0.013782228,
-0.012937729,
0.014241636,
0.0015209432,
0.019376192,
0.028321128,
0.0074653737,
0.026253793,
0.011877038,
-0.022456925,
0.0035029831,
0.0041684485,
-0.0043745064,
-0.0015952592,
0.014579436,
0.0061648446,
-0.0076410295,
0.014701043,
-0.002349397,
0.00037136857,
-0.012437785,
-0.0134376725,
-0.035644624,
0.010748787,
-0.0064181946,
0.01726832,
-0.005955409,
-0.01135007,
0.029618278,
0.009330028,
-0.0063168546,
-0.037941664,
-0.009573244,
0.00060423923,
-0.01720076,
0.0014711177,
0.020078816,
-0.013187701,
0.021727277,
0.011802722,
0.004573808,
-0.030672215,
-0.00794505,
0.0031905184,
-0.012748561,
-0.0063168546,
0.00009748689,
-0.015322595,
0.0012996844,
0.029456135,
-0.022321805,
-0.003560409,
-0.024929618,
-0.011079831,
-0.011613554,
0.02357842,
0.026848322,
0.0065094004,
0.0043272143,
0.0064519746,
-0.029239943,
-0.016971057,
-0.016727842,
0.0017987834,
-0.026821297,
-0.01141763,
0.005141312,
-0.013059337,
-0.0073843016,
0.0115392385,
0.0009889087,
-0.009600268,
0.017389929,
0.16560294,
0.003695529,
0.0021804972,
0.026145699,
-0.018808689,
0.0030739773,
0.023862172,
-0.018930295,
-0.0037664669,
0.010992003,
0.025402538,
-0.0007950961,
-0.022416389,
-0.00801261,
0.013984908,
-0.02093007,
-0.018660055,
-0.028375177,
-0.010228575,
-0.027064513,
-0.015011819,
-0.00699921,
0.029050775,
0.006124309,
0.02283526,
0.0015462782,
0.0038374048,
0.015592835,
0.057723217,
0.019605896,
-0.0053811492,
0.022281269,
0.0053575034,
0.0016754866,
0.00860038,
-0.002442292,
0.0075734695,
-0.024132412,
-0.009532708,
-0.007458618,
-0.02432158,
-0.0013452873,
-0.018768152,
0.008222045,
-0.025794387,
0.034428548,
0.011910818,
-0.030564118,
-0.02351086,
0.0064452183,
-0.031699125,
-0.015552299,
-0.00023667092,
0.0134038925,
0.0032631452,
-0.019808576,
0.015444203,
0.012809365,
-0.0031466044,
-0.0032175423,
-0.0051109097,
0.005901361,
-0.007289718,
0.0017734485,
-0.013647108,
0.027577968,
-0.0013131964,
-0.0050838855,
-0.007120818,
-0.005945275,
0.0016332616,
-0.024780987,
-0.010647447,
0.0011527415,
-0.020403102,
-0.01162031,
0.011600042,
0.02494313,
0.0054487092,
-0.0041076443,
-0.0010590021,
-0.004313702,
-0.004624478,
0.023254132,
-0.014890212,
-0.032807108,
0.01460646,
0.025307955,
-0.014890212,
-0.012998533,
0.00954622,
-0.019322144,
-0.013383625,
0.0073302537,
0.010438011,
-0.0056615234,
0.015430691,
-0.008985473,
-0.002560522,
0.012255373,
-0.027969817,
0.09366511,
0.008580113,
-0.016552186,
0.0016856205,
0.0076004937,
-0.019686967,
0.025402538,
0.0032411884,
-0.006985698,
-0.01413354,
0.006759372,
-0.0003777023,
-0.013667377,
-0.015309083,
0.03642832,
0.0077829054,
-0.034914978,
0.016322482,
-0.017254809,
0.012268886,
-0.023456812,
-0.004948766,
0.016917009,
-0.0032276763,
-0.02561873,
-0.03232068,
0.014390267,
-0.012971509,
-0.006056749,
0.002280148,
0.0019879513,
0.0002508163,
-0.0032057192,
-0.0030942454,
0.029915543,
-0.011431143,
-0.008559844,
0.013410648,
0.018538449,
-0.007127574,
-0.014241636,
0.020200422,
0.008924669,
0.0142011,
-0.008613893,
0.011093343,
0.002288593,
-0.03140186,
-0.00005737317,
-0.011559506,
-0.023537884,
0.014498364,
0.0027142207,
0.022537997,
-0.020335542,
-0.005979055,
-0.033969138,
-0.00713433,
0.019862624,
-0.016835937,
0.0025588328,
0.0064452183,
-0.018092552,
0.01141763,
0.010478547,
-0.17046724,
0.008776037,
0.0054014176,
-0.0066141183,
0.037347138,
0.0116405785,
0.019578872,
0.0051683355,
-0.013687644,
-0.00710055,
0.008282849,
0.003567165,
-0.009762412,
-0.012985021,
0.010546107,
0.004938632,
-0.0040029264,
0.027604993,
0.015322595,
-0.0073505216,
0.015849562,
-0.015187475,
0.031131621,
-0.02167323,
0.007087038,
0.012336446,
-0.017552074,
0.00062661845,
0.00231055,
-0.0050129476,
-0.021781325,
-0.012944485,
0.03337461,
-0.01602522,
0.008492284,
0.0029456136,
-0.0072829616,
-0.021835374,
-0.026010578,
0.026064625,
-0.0019051904,
0.01998423,
-0.007850465,
-0.007965317,
-0.019281607,
0.016903497,
0.01158653,
-0.029321015,
0.01637653,
-0.011600042,
0.0077221016,
-0.010823103,
0.00900574,
0.019484287,
0.01801148,
0.023564909,
-0.013289041,
0.016403554,
0.004056975,
-0.016335994,
-0.0043035685,
-0.0003171095,
0.007053258,
0.021430014,
-0.015011819,
-0.034752835,
0.0044657122,
-0.0137079125,
-0.0015082757,
0.034942,
-0.024578307,
-0.0052325176,
0.0043069464,
-0.017214274,
0.034509618,
0.0162279,
-0.011160903,
0.025294442,
-0.01124873,
0.018092552,
-0.0008276093,
0.032104485,
-0.013316065,
-0.020065304,
0.0009787746,
0.02418646,
0.02263258,
0.0066411425,
0.029591255,
-0.029888518,
-0.011843258,
-0.0324558,
0.01568742,
-0.023064965,
-0.008850353,
0.025564682,
0.0089652045,
-0.012694513,
0.00893818,
-0.016187362,
0.004871072,
-0.008120705,
-0.019105952,
0.003590811,
0.020065304,
0.012822877,
-0.004803512,
-0.00071233517,
0.0063540125,
-0.006154711,
0.009742144,
0.0038745627,
0.0025064738,
0.023605444,
-0.011458166,
-0.008958449,
-0.0053000776,
-0.020754414,
-0.01575498,
-0.026334865,
0.05307509,
0.0075937374,
-0.015322595,
-0.005806777,
-0.0009872196,
-0.03499605,
-0.12733698,
-0.031618055,
0.005948653,
0.03283413,
0.007816685,
0.009019252,
0.0017447355,
0.03342866,
0.014160564,
0.028834583,
-0.018335769,
-0.010856883,
0.0087355,
-0.018876247,
0.039265838,
-0.00811395,
0.008640917,
-0.006174979,
-0.024537772,
0.04994031,
-0.0035975669,
-0.009471904,
0.0021602293,
-0.022416389,
-0.0008529443,
0.0026703067,
-0.00066166517,
0.01610629,
0.007391058,
0.013241749,
0.015714442,
-0.0020048413,
0.009742144,
0.0031347813,
-0.025997067,
0.000135331,
0.01195811,
-0.029780423,
0.04594076,
-0.04213038,
-0.0043103243,
0.010438011,
0.046400167,
0.0007178244,
0.012147278,
-0.015876587,
-0.049372807,
-0.007147842,
-0.012579662,
-0.017498026,
-0.016660282,
0.0053439913,
-0.013971396,
0.011039294,
0.035995938,
-0.015660394,
0.029942567,
0.02126787,
-0.024010804,
0.0014660507,
0.009363808,
-0.012079718,
-0.022929845,
0.0178088,
0.011735162,
-0.021929957,
-0.018903272,
-0.03140186,
-0.010228575,
-0.016998082,
-0.017065642,
0.0020352432,
0.0038002469,
-0.00720189,
-0.04580564,
-0.0010057987,
0.018322257,
-0.010383964,
0.005756107,
0.01821416,
-0.020295007,
-0.0132349925,
0.011877038,
-0.011910818,
-0.019592384,
0.032996275,
0.024902595,
0.011633822,
-0.006016213,
-0.01971399,
-0.00914086,
0.011613554,
-0.0015699242,
-0.0007359811,
0.010296135,
0.012593173,
-0.0026314599,
-0.011809478,
0.036077008,
0.0111000985,
-0.0064621083,
-0.03202341,
-0.049318757,
0.01460646,
0.019551847,
-0.020430127,
0.003955635,
0.0070397463,
0.03418533,
0.018700592,
0.00028290725,
0.015322595,
-0.03513117,
0.0015336107,
-0.013849788,
-0.007870734,
-0.017903386,
-0.020308519,
0.029321015,
-0.01189055,
0.028321128,
-0.00031478712,
0.00910708,
0.0040637306,
-0.007512666,
0.019686967,
-0.0015910367,
0.005641255,
0.0044285543,
0.012870169,
-0.0020740903,
0.007924781,
-0.008458504,
-0.036212128,
0.015863074,
-0.013275528,
-0.0091678845,
0.0026399049,
-0.008370677,
0.036941778,
0.012295909,
0.024659378,
-0.027064513,
-0.009113836,
0.009782679,
-0.023119012,
0.0055432934,
-0.0011206506,
-0.022389365,
0.030726261,
-0.016538674,
-0.023605444,
0.014660507,
-0.0009399277,
0.0029709486,
-0.025037715,
-0.048535064,
0.013687644,
0.0028138717,
0.010924443,
-0.010215064,
-0.011228463,
0.033347588,
-0.004985924,
0.005965543,
-0.0026922638,
0.012822877,
-0.010579887,
-0.018943807,
0.0039252327,
0.013545768,
0.011491946,
-0.028780535,
-0.021294894,
-0.0053135897,
0.008850353,
0.017133202,
-0.008830084,
0.012843145,
-0.004779866,
-0.003386442,
-0.008580113,
-0.005742595,
-0.015484739,
-0.034617715,
0.010316404,
-0.000617329,
-0.004985924,
-0.0031415373,
0.03526629,
-0.030969478,
-0.011904062,
-0.01372818,
-0.010147504,
-0.009654316,
0.009127349,
0.015106403,
0.024145924,
0.0030621544,
-0.0040907543,
-0.007411326,
0.016403554,
0.0027057757,
0.0131674325,
0.00086392276,
-0.018727615,
-0.005796643,
0.010059675,
-0.018173624,
-0.03548248,
-0.0110663185,
0.008397701,
0.023591932,
0.007546446,
0.007222158,
0.013782228,
-0.000850833,
-0.005137934,
-0.013714668,
0.0063168546,
-0.00860038,
0.0130998725,
-0.00054470205,
0.019038392,
0.016795402,
0.0029185896,
0.011424386,
-0.0054960013,
0.024862058,
-0.023348717,
0.024997178,
0.0007604716,
0.020578759,
0.00794505,
-0.042184427,
0.005242652,
-0.00467177,
-0.048481014,
0.006100663,
0.021835374,
0.020848999,
0.07453213,
-0.012431029,
-0.021173285,
-0.0064587304,
-0.0043711285,
0.0034269781,
-0.0063405004,
0.003661749,
0.0107622985,
-0.03975227,
0.005843935,
-0.0094043445,
0.03521224,
-0.030428998,
-0.028861608,
-0.00433397,
0.0052122497,
0.046643384,
0.00951244,
-0.022389365,
0.025726827,
-0.02364598,
0.0009399277,
0.018065529,
-0.01590361,
-0.0027361778,
0.016741354,
-0.03704987,
-0.009147616,
-0.034374498,
0.003475959,
0.015025332,
-0.027807672,
-0.018497912,
-0.008140973,
0.013356601,
0.004279922,
-0.0038103808,
-0.0041583143,
-0.012268886,
-0.034833908,
0.04585969,
-0.016606234,
-0.022983892,
-0.01610629,
-0.03718499,
-0.021727277,
-0.008951693,
-0.019376192
] |
Cells acquire their ultimate identities by activating combinations of transcription factors that initiate and sustain expression of the appropriate cell type-specific genes. T cell development depends on the progression of progenitor cells through three major phases, each of which is associated with distinct transcription factor ensembles that control the recruitment of these cells to the thymus, their proliferation, lineage commitment and responsiveness to T cell receptor signals, all before the allocation of cells to particular effector programmes. All three phases are essential for proper T cell development, as are the mechanisms that determine the boundaries between each phase. Cells that fail to shut off one set of regulators before the next gene network phase | [
-0.020026043,
-0.02103126,
-0.0029552772,
-0.030417653,
-0.011755835,
0.017623961,
-0.013929457,
0.008439919,
-0.024321066,
-0.016670963,
0.017584797,
0.0058942363,
0.003808734,
0.014817183,
-0.011932075,
-0.011644869,
0.028877188,
-0.0162271,
-0.017911166,
0.0077675977,
-0.026579546,
0.0066448865,
-0.0013413792,
-0.040600386,
-0.015861565,
0.013250608,
0.0045430656,
-0.039294906,
-0.013498649,
-0.012408574,
0.024699656,
0.011710144,
0.0006861922,
-0.0062238695,
-0.012317191,
-0.011090041,
-0.0054601645,
-0.025352394,
0.018133098,
0.01885111,
0.02932105,
0.032663077,
-0.019529961,
0.015104388,
-0.011860274,
-0.0051794867,
-0.0015070119,
-0.009399446,
-0.021644836,
0.03665784,
0.006090058,
0.0048041614,
-0.005701678,
-0.005192541,
-0.024464669,
-0.016305428,
-0.012558704,
0.02348556,
-0.00217199,
-0.013433375,
-0.014543032,
-0.016122662,
-0.0041873227,
0.0051305313,
0.009184042,
0.022402013,
0.0069190366,
0.021501234,
0.008596577,
0.0040600384,
0.027702257,
0.014125279,
0.0040078196,
0.019412467,
0.018224481,
-0.008746707,
-0.014895511,
-0.009778035,
-0.014999949,
0.005855072,
-0.00015420966,
-0.025052136,
-0.015561305,
0.027597819,
0.0025130464,
-0.0053720446,
0.020561289,
0.014007785,
0.015065224,
-0.004817216,
0.019425523,
0.023002533,
0.02929494,
0.03610954,
0.009549576,
-0.009177514,
0.013237554,
0.024321066,
-0.016697071,
-0.019934658,
-0.018407248,
0.01374669,
0.0040469836,
-0.009634432,
-0.04154033,
0.006387054,
0.016644852,
-0.00020449099,
0.019699672,
-0.03417743,
-0.032793622,
0.031462036,
-0.022702273,
-0.054934543,
0.039921537,
0.011227116,
0.008962111,
0.005623349,
-0.011338082,
-0.0018129834,
0.015809346,
0.018446414,
0.015078278,
-0.0231853,
0.02086155,
0.005280661,
0.007930783,
-0.0070691667,
-0.023576945,
0.007154023,
0.02343334,
-0.0032082137,
-0.008942529,
0.041462,
-0.023498615,
-0.023472507,
-0.0023612846,
0.0052643428,
0.008994748,
-0.01737592,
-0.0002839416,
0.019399412,
-0.008407283,
-0.002795356,
0.0075260843,
0.012539122,
0.013054786,
0.0060933214,
-0.0042754426,
-0.0021409849,
0.004761733,
-0.009699706,
0.036814496,
-0.022193138,
0.0102610625,
0.009197097,
-0.0052871886,
0.025404613,
-0.01054174,
-0.0071931873,
0.021200974,
-0.0018570434,
0.009934693,
0.005603767,
0.027310614,
0.026945079,
0.023942478,
0.015652688,
-0.0040306654,
-0.0016726445,
0.0057995887,
-0.0032734878,
-0.01892944,
0.0042428058,
-0.0010174575,
0.0095169395,
-0.008818508,
0.007284571,
-0.02994768,
-0.0025130464,
0.00012636626,
0.023041697,
0.020365467,
-0.0042754426,
-0.015652688,
0.0009228102,
0.0080091115,
-0.010176206,
-0.0072976258,
-0.0087923985,
-0.012036513,
0.00398171,
0.027153956,
-0.0024918322,
-0.6349848,
-0.0123628825,
0.026657874,
-0.022493396,
-0.009386391,
0.024255794,
-0.000859984,
-0.010489521,
-0.040783152,
0.024647437,
-0.003776097,
0.0062434515,
0.0074151186,
-0.022140918,
-0.020182699,
-0.039999865,
-0.010809363,
-0.017206209,
0.019595234,
0.009046967,
-0.015430758,
-0.023746656,
0.00015125194,
0.039321017,
-0.023237519,
0.020835439,
0.02391637,
-0.0034725731,
0.012402047,
0.02544378,
-0.014125279,
-0.0018456205,
0.004722569,
-0.0077937073,
0.044360165,
0.012284554,
-0.0026648082,
0.020221865,
0.00083713816,
0.03117483,
-0.0021752538,
-0.010143569,
0.024869367,
0.017780619,
-0.00811355,
0.00826368,
-0.01464747,
0.00007057744,
0.017937277,
0.004999983,
0.013590032,
-0.008133132,
-0.026683982,
0.0002765983,
0.019869385,
-0.008309372,
0.019738836,
0.0038870627,
0.004680141,
-0.027623927,
-0.009549576,
0.019764947,
-0.03060042,
0.003439936,
-0.003053188,
0.0138511285,
0.00796342,
0.0074216463,
-0.00080205343,
-0.0037989428,
0.0019826957,
0.016135717,
-0.0035052102,
-0.011501267,
0.000699247,
0.032140885,
0.0005103606,
-0.019529961,
0.022924205,
0.018146154,
-0.0043178704,
-0.008185351,
-0.019569125,
0.008668378,
0.018224481,
-0.00610964,
-0.0019206854,
0.011246698,
-0.0070626396,
0.018459467,
0.0032473782,
-0.0054569007,
0.001958218,
-0.041984193,
-0.017441195,
0.020469906,
0.0033942445,
-0.011690561,
0.007924255,
-0.020691836,
0.0067689065,
-0.010972548,
0.023276685,
0.012780636,
0.017219264,
-0.0079895295,
-0.018041715,
0.0030515564,
0.05088756,
-0.019947713,
-0.003916436,
0.00813966,
-0.021096535,
-0.004108994,
-0.006289143,
-0.01557436,
0.004676877,
0.03621398,
-0.003452991,
-0.013629197,
0.03958211,
0.00035615088,
0.010900747,
-0.0018815211,
0.021749275,
0.013550868,
-0.009745398,
-0.010672288,
-0.0062434515,
0.0015347534,
0.0029095856,
-0.016670963,
0.013459485,
-0.02501297,
0.017610908,
0.0025620018,
0.021631781,
0.0011700352,
0.019778002,
-0.014164443,
-0.0196344,
-0.013217971,
0.0094973575,
-0.0044614733,
-0.018590016,
-0.014464703,
-0.005280661,
-0.012101787,
0.004164477,
-0.022780603,
0.013563923,
0.013191862,
-0.013759744,
-0.00916446,
0.027075626,
-0.004402727,
-0.01925581,
-0.02656649,
0.009105713,
-0.020704892,
-0.010724507,
0.027885024,
0.00072902825,
0.015783237,
-0.016670963,
0.009980384,
-0.018250592,
0.013217971,
-0.0020903978,
-0.037180033,
0.011494739,
-0.019999932,
-0.018616125,
0.016135717,
-0.0029911778,
0.006044366,
-0.0012426524,
-0.0031886315,
0.00610964,
-0.003280015,
-0.011253226,
-0.016775401,
-0.0045365384,
-0.0034464635,
0.0280939,
-0.0029324314,
0.028694421,
0.0034660457,
0.0045136926,
0.043080796,
-0.030469872,
0.007532612,
-0.025469888,
0.018002551,
0.012917711,
-0.031096501,
0.021723164,
0.014334155,
0.00048996246,
0.027571708,
-0.000978293,
0.00064090843,
0.01404695,
-0.02351167,
0.0038478982,
-0.014190553,
-0.008603104,
-0.019242754,
-0.008413809,
0.0196344,
-0.0064196913,
0.011925547,
-0.01590073,
-0.0045561204,
0.015326319,
0.017885057,
0.008896837,
0.003733669,
-0.010626596,
-0.009184042,
0.005430791,
-0.0005417736,
0.028250558,
-0.017349811,
-0.012388992,
0.022506451,
0.017297592,
0.004637713,
0.009484302,
-0.010652706,
-0.01114226,
-0.020469906,
-0.0015347534,
-0.0020414423,
0.019360248,
0.014660525,
0.0021785174,
-0.01584851,
0.018655289,
0.0008138843,
0.021932041,
0.016723182,
-0.010613541,
-0.0014156284,
-0.009229734,
-0.01980411,
0.042454164,
-0.0048824903,
-0.015078278,
0.0050456747,
-0.012467321,
0.027049517,
-0.010783253,
-0.027388941,
0.013191862,
-0.0034986828,
0.01372058,
0.010593959,
0.030234884,
0.023668328,
0.0137728,
-0.0024934642,
-0.00038736,
-0.01324408,
-0.007539139,
0.023093916,
0.0029079537,
-0.020117426,
-0.009399446,
-0.010274117,
-0.029712694,
0.012826327,
0.026370669,
-0.022950314,
0.010783253,
0.005434055,
0.0037173503,
-0.0017069133,
-0.0045659114,
0.008433392,
0.011174897,
-0.01006524,
0.019712728,
0.055195637,
-0.013139643,
0.002785565,
-0.027362833,
-0.01860307,
0.001107209,
-0.00961485,
-0.0010141938,
0.004259124,
0.0026370669,
-0.01644903,
-0.00096850196,
-0.0046083396,
0.0121344235,
-0.0029079537,
0.011651397,
-0.02291115,
0.014843293,
-0.021592617,
-0.017388975,
0.00022641895,
0.03783277,
0.0013421952,
-0.013576978,
-0.022898095,
-0.00096442236,
-0.03720614,
-0.016736235,
-0.015261046,
0.007127913,
-0.023394177,
0.021801494,
-0.010345918,
0.013472539,
0.013929457,
0.027232284,
-0.0051403223,
-0.0140991695,
-0.030156557,
0.014960785,
0.0009097554,
0.027623927,
0.025052136,
-0.00557113,
0.017193154,
-0.029503817,
-0.0037728332,
-0.010874637,
-0.016670963,
0.041096468,
-0.0020903978,
0.0028589983,
0.00813966,
0.0100717675,
-0.0118080545,
-0.0033518164,
0.023694437,
-0.0073367897,
-0.001214911,
-0.022937259,
-0.007630523,
0.00035451906,
0.018172262,
0.028563872,
0.019751891,
0.0126109235,
-0.0016840674,
0.012891602,
0.035822332,
-0.00625977,
0.0018113516,
0.0033713987,
0.009503884,
0.0024706183,
0.0065894034,
0.0035574292,
0.0016090025,
-0.0043505076,
0.02261089,
-0.001850516,
0.016083498,
0.018302811,
0.014190553,
0.026044298,
-0.028433325,
-0.020639617,
0.0050358837,
0.0045659114,
0.0024918322,
0.0120756775,
-0.021997316,
0.011697088,
-0.028642202,
-0.025783204,
-0.0131461695,
-0.008452974,
0.0021230346,
0.0012173589,
-0.018237537,
0.025887642,
-0.029399378,
-0.0058452804,
-0.031462036,
0.027362833,
-0.008446447,
-0.00048384303,
-0.0112923905,
0.006840708,
-0.0016653012,
-0.017689236,
-0.021932041,
0.016840674,
-0.020221865,
-0.022049535,
0.027702257,
0.018746674,
0.029164393,
0.008740179,
-0.0049575553,
-0.003988237,
0.02989546,
0.002247055,
-0.020835439,
-0.0055450206,
-0.018133098,
-0.005518911,
0.018015604,
0.008922947,
-0.03180146,
0.014255826,
0.0113185,
-0.01176889,
-0.0037238777,
0.011677506,
-0.0050293566,
-0.033211377,
0.017689236,
0.027023409,
0.010822418,
0.0051501133,
-0.0042558606,
-0.03430798,
-0.008439919,
-0.0082571525,
-0.016945112,
-0.0076892693,
-0.02351167,
0.0045267474,
0.012173588,
-0.03548291,
-0.023289738,
0.007983002,
-0.015195771,
0.00796342,
0.0038054702,
0.015430758,
0.03177535,
0.022506451,
0.0020838703,
0.006703633,
-0.013798909,
-0.0052023325,
-0.0250913,
0.04216696,
0.0013022149,
-0.030469872,
-0.0023971852,
-0.008270207,
-0.0060411026,
-0.01737592,
0.007369427,
-0.01272189,
0.036945045,
0.016305428,
-0.012754526,
-0.010959493,
0.0014686635,
-0.0046834047,
0.025287122,
0.023472507,
-0.01707566,
-0.0137728,
0.007467338,
0.00557113,
-0.033759676,
0.036318414,
-0.03347247,
-0.009810672,
0.008596577,
0.02937327,
0.018590016,
-0.007956892,
0.0024135036,
-0.028485544,
-0.016684016,
-0.0037401963,
-0.03712781,
0.0113511365,
-0.03049598,
0.03297639,
0.040809263,
0.020026043,
0.015365483,
0.02749338,
0.0070822216,
-0.00036981763,
0.009157932,
-0.005613558,
0.043785755,
-0.0088642,
0.019020824,
-0.011435993,
-0.012167061,
0.033994664,
-0.0280939,
0.035535127,
0.038746607,
-0.017715344,
-0.037519455,
0.031357598,
-0.012702307,
-0.028589983,
0.023368068,
-0.0053002434,
0.016684016,
-0.02201037,
0.014334155,
0.011749308,
0.022584781,
-0.0061683864,
0.020104371,
0.011546958,
-0.0016008432,
0.01219317,
-0.010711452,
0.0103655,
-0.019308029,
-0.016618744,
-0.01584851,
-0.015979059,
0.011298917,
-0.007532612,
0.012284554,
0.005864863,
-0.010234953,
-0.011037822,
0.0041122576,
-0.025156572,
-0.04339411,
-0.013237554,
-0.014804128,
-0.014569142,
-0.021057371,
-0.0026125892,
-0.0027415052,
-0.014751908,
-0.008622686,
-0.014699689,
0.00010051166,
-0.0050260928,
-0.031357598,
0.031018171,
-0.016122662,
0.02806779,
-0.018120043,
0.026279286,
0.030365434,
0.019843275,
-0.014033895,
-0.032062557,
-0.023250574,
0.012029986,
0.04404685,
0.01562658,
-0.003387717,
0.015691854,
0.002398817,
0.0064719105,
-0.015652688,
-0.008681433,
-0.0058811815,
-0.012010403,
0.0021426168,
0.003301229,
-0.0055874484,
-0.029582147,
-0.015509086,
-0.005580921,
0.024477724,
-0.004797634,
-0.026579546,
-0.021971205,
0.018720564,
-0.02326363,
-0.010979075,
0.004843326,
-0.010110932,
-0.012689252,
-0.025104355,
-0.008368118,
-0.015757127,
-0.0077414885,
0.01562658,
0.0037826244,
0.0046344493,
0.023707492,
0.009543049,
-0.016644852,
0.0090796035,
0.010502576,
0.03908603,
-0.00913835,
-0.0026109572,
-0.0058811815,
0.0069255643,
0.00061235105,
0.0106070135,
-0.0074085915,
-0.010234953,
-0.016971223,
-0.010372028,
0.0151304975,
-0.0011732989,
-0.0044484185,
0.0036292307,
-0.01051563,
-0.019608289,
-0.022663109,
-0.018825002,
0.0032963336,
-0.026631765,
0.015913785,
0.024399396,
0.032689184,
0.015430758,
-0.0022731647,
0.0049738735,
-0.015770182,
0.034595184,
-0.007800235,
0.025300177,
0.0146735795,
0.013191862,
-0.011233644,
0.009660542,
-0.02536545,
-0.023707492,
0.010006494,
-0.02539156,
-0.03287195,
0.004389672,
0.008250625,
0.015026059,
0.004980401,
-0.020939877,
-0.0043766173,
0.008805454,
0.017349811,
-0.009660542,
-0.018524742,
0.010489521,
-0.018093934,
-0.0118276365,
0.017388975,
0.0045985486,
0.007715379,
-0.0028459434,
-0.013028677,
0.022819767,
-0.0065991944,
-0.0027594555,
-0.015509086,
0.014960785,
-0.026409833,
0.014360265,
0.005616822,
-0.015966004,
0.0048008976,
0.0061912322,
0.0058942363,
-0.0113511365,
-0.018838057,
0.015783237,
0.007819817,
0.02994768,
-0.009125296,
0.008041749,
0.0018374611,
-0.04394241,
-0.026736202,
-0.0011121046,
-0.020574342,
0.03185368,
0.002119771,
-0.009210152,
-0.020796275,
-0.0011773786,
-0.0373628,
-0.015208826,
0.016214045,
0.003818525,
0.0063152527,
0.0037728332,
-0.025626546,
0.008701015,
-0.000076186916,
0.013381156,
0.0068145986,
-0.006853763,
0.028903296,
0.020952933,
0.0017607643,
-0.0098172,
-0.03924269,
-0.022780603,
0.032950282,
-0.028616091,
-0.007643577,
-0.0059105544,
-0.035065155,
0.044177398,
-0.023302794,
0.025992079,
-0.014699689,
0.02648816,
0.02937327,
-0.023302794,
0.0047258325,
-0.00019653572,
-0.012682725,
-0.011507794,
0.0051272674,
-0.014321101,
0.0045006378,
0.008609632,
0.000036869573,
-0.03561346,
0.008720597,
-0.016357647,
0.03785888,
0.022402013,
-0.0027594555,
0.0060508936,
0.011703616,
-0.0074412283,
-0.012016931,
0.0062565063,
-0.0152741,
-0.0049510277,
-0.01579629,
-0.0029291676,
-0.012597869,
0.0052349693,
-0.016462086,
-0.020052152,
-0.014477758,
0.005486274,
-0.019947713,
-0.04467348,
0.0038870627,
-0.009053495,
-0.027571708,
0.0075456663,
-0.008015639,
-0.030522091,
-0.02443856,
-0.0033224432,
-0.00053687807,
-0.013341991,
0.0037565148,
-0.02626623,
0.0054471097,
0.012982985,
-0.0094973575,
0.009184042,
-0.018133098,
-0.0005776743,
0.1939419,
-0.041670877,
-0.01620099,
-0.0044255727,
0.0039556003,
-0.0038805353,
0.015717963,
0.0024918322,
-0.016932057,
-0.0039849733,
-0.0014376583,
0.012238862,
-0.013994731,
-0.0029732275,
0.02866831,
-0.02173622,
-0.026214011,
0.00047527583,
-0.016618744,
-0.00068986387,
0.016827619,
-0.010593959,
0.0095561035,
-0.011605705,
0.06005202,
0.00027802616,
-0.012943821,
0.018994715,
0.017415086,
-0.012943821,
-0.043368,
0.015287154,
-0.012101787,
0.010117459,
-0.0032947017,
0.0034464635,
-0.0013258767,
-0.022741437,
0.008622686,
-0.011710144,
0.007630523,
0.009203624,
-0.006755852,
-0.0049445005,
0.028302778,
0.025678765,
-0.0116187595,
-0.008061331,
-0.0040828846,
-0.02391637,
-0.025939861,
0.003270224,
0.0041383673,
0.004409254,
0.0015021163,
0.0018554116,
0.0061781774,
0.012584814,
-0.00015094597,
0.023629162,
-0.02656649,
0.0056527224,
-0.028511653,
0.015182717,
-0.0071670776,
0.012513013,
-0.0031168303,
0.0028443115,
0.02285893,
-0.041670877,
-0.022819767,
0.018172262,
-0.01650125,
0.002462459,
-0.005499329,
-0.01590073,
0.036240086,
0.0054797465,
0.0146735795,
0.012291081,
0.04381186,
-0.0018015605,
-0.029007735,
0.0011684034,
0.01407306,
-0.02561349,
0.03592677,
-0.0041481582,
-0.018237537,
-0.008015639,
0.009471248,
-0.015013005,
-0.00634789,
-0.0019092625,
-0.0045430656,
-0.002496728,
0.006595931,
0.0042721787,
0.0024885687,
-0.0065339208,
-0.0390077,
0.07357678,
0.016618744,
0.01832892,
-0.0068472354,
0.024099136,
0.0072519337,
-0.0031151983,
-0.00018337896,
-0.018485578,
0.004402727,
-0.007911201,
0.018864166,
-0.012539122,
-0.0058256984,
0.022832822,
-0.0017313911,
-0.017819783,
0.03420354,
-0.013825019,
-0.0018652026,
-0.03898159,
-0.0052937157,
0.016971223,
0.015391593,
-0.003066243,
-0.0024249265,
0.0151304975,
0.0015314897,
-0.017415086,
0.0069255643,
-0.0111030955,
-0.0006596747,
0.021396795,
0.005166432,
-0.03652729,
0.009797617,
-0.019151371,
-0.03422965,
0.033550803,
-0.019999932,
-0.0106070135,
0.0100130215,
-0.0077088512,
-0.0027708784,
-0.01191902,
0.021409849,
0.010554795,
-0.016357647,
-0.019425523,
0.0017216,
0.0018031923,
-0.0040502474,
-0.016161826,
0.024986861,
-0.026462052,
-0.0102806445,
-0.0162271,
0.009745398,
0.008204933,
-0.014843293,
0.018433359,
-0.0132963,
-0.010985603,
-0.0024461406,
-0.011566541,
-0.16187935,
0.000978293,
0.022023425,
-0.0030711384,
0.029033845,
0.01685373,
0.0059986743,
0.014934676,
-0.010789781,
0.019007768,
0.05013038,
-0.007369427,
-0.04086148,
-0.021644836,
0.0059236092,
-0.0075456663,
-0.02381193,
0.041827537,
0.005257815,
0.018759727,
0.007669687,
-0.011794999,
0.016670963,
0.0048890174,
-0.0022323686,
0.006370736,
0.018642236,
-0.031905897,
-0.025535163,
-0.012029986,
-0.016370703,
0.007930783,
0.024516888,
-0.011814581,
0.010026076,
0.011533904,
-0.0039327545,
-0.0055025923,
0.0050260928,
0.0192297,
0.013204916,
0.009197097,
0.0042787064,
0.009647487,
-0.0044386275,
0.032715295,
-0.013381156,
-0.0032310595,
0.013276718,
-0.0048988084,
0.021827603,
-0.00079756585,
-0.014856347,
0.016618744,
0.03347247,
-0.020026043,
-0.006187969,
0.013929457,
-0.0014025737,
0.0030711384,
0.0035378472,
0.01439943,
0.030574309,
-0.010959493,
-0.0036683949,
-0.02110959,
-0.009503884,
0.01191902,
-0.043602988,
0.009523466,
-0.008622686,
-0.010763671,
0.018916385,
-0.028485544,
0.0038054702,
0.014412484,
-0.02233674,
0.006938619,
0.0050489386,
0.010952965,
-0.012375938,
0.020613508,
-0.013733636,
-0.022219246,
-0.029738802,
0.0032147411,
0.013629197,
0.03240198,
-0.015117442,
-0.008635741,
0.004056775,
-0.018341975,
-0.023746656,
0.004357035,
0.043080796,
0.017872002,
-0.0071670776,
-0.022623945,
-0.004601812,
0.0065339208,
0.035770115,
-0.019386359,
-0.007473865,
0.0056494586,
0.029399378,
-0.00038817592,
-0.025887642,
0.002034915,
0.03292417,
0.013054786,
-0.0009162828,
0.025939861,
0.0128589645,
0.011990821,
-0.0032783833,
0.025900695,
-0.014569142,
-0.0008950688,
0.010385082,
-0.000094494215,
0.07712768,
0.012016931,
0.00058705744,
0.040548168,
-0.0026729675,
-0.022271466,
-0.15289766,
-0.016057387,
0.0065796124,
0.01797644,
0.00005400398,
0.021501234,
-0.003397508,
0.014451648,
-0.012532595,
0.012349828,
-0.027806696,
-0.00509463,
0.0024575635,
-0.03287195,
-0.0024755138,
0.0052741338,
0.025678765,
-0.011148787,
-0.02416441,
0.031905897,
-0.0025799521,
0.004246069,
-0.010456884,
-0.0115991775,
0.0015192508,
0.0036422855,
-0.043368,
0.00006252019,
0.00004288701,
0.0069320914,
-0.0036422855,
-0.008433392,
0.033916336,
-0.011187952,
-0.0045365384,
0.013263663,
-0.016866785,
-0.026501216,
0.0384594,
-0.009608323,
-0.01066576,
0.004934709,
-0.00037838484,
-0.015456867,
0.007865509,
-0.02228452,
-0.0131265875,
0.0057147327,
0.008211461,
-0.013231026,
-0.027388941,
-0.038903262,
-0.029451597,
-0.019673564,
-0.0070300023,
-0.016644852,
0.010039131,
0.01266967,
0.006279352,
0.0009211784,
0.019347193,
-0.009569159,
-0.00093423313,
-0.007389009,
0.040730935,
-0.013785854,
-0.02997379,
-0.030861516,
0.03958211,
-0.036422852,
-0.00073718745,
-0.011435993,
-0.015913785,
0.011422938,
-0.017819783,
0.0146344155,
-0.022193138,
-0.012539122,
0.020234918,
-0.03475184,
-0.0016497986,
-0.0177284,
0.02506519,
-0.003603121,
0.03856384,
0.0038772714,
0.015665743,
-0.0067623793,
-0.0030499245,
-0.008622686,
-0.007911201,
0.028276667,
0.004817216,
0.0026011663,
-0.017741455,
-0.0036422855,
0.0020055415,
-0.008727125,
0.009849836,
0.020913769,
0.0011961448,
-0.011507794,
-0.04018263,
0.0052219145,
-0.017898113,
0.0021344575,
0.013002567,
-0.01464747,
-0.0133354645,
-0.023890259,
-0.0025456834,
0.0070952764,
0.022114808,
-0.015065224,
-0.0133158825,
0.0048890174,
-0.026527327,
-0.021070424,
0.021396795,
-0.016605688,
0.018511686,
0.02503908,
-0.0035378472,
-0.02479104,
0.011187952,
0.0064947563,
-0.014712744,
-0.012793691,
0.003182104,
0.01584851,
0.00004604872,
-0.0120756775,
0.01805477,
-0.03177535,
-0.004924918,
-0.010496048,
-0.022206191,
-0.013368101,
0.0057147327,
0.030730966,
0.03913825,
0.03360302,
0.0018766256,
-0.028772749,
0.0013462749,
0.0035019463,
-0.002614221,
-0.0012679461,
-0.041853644,
0.0019206854,
-0.0007616652,
0.005248024,
0.038746607,
0.018198373,
0.003439936,
-0.018511686,
-0.024947697,
0.005084839,
0.001376464,
-0.026788421,
-0.00535899,
-0.0305482,
0.014986895,
0.03185368,
0.0053165616,
0.007976474,
-0.019294973,
-0.03002601,
-0.031227048,
-0.0057930616,
0.0058256984,
-0.016422922,
-0.0031690493,
0.023198355,
0.01898166,
-0.010593959,
0.019947713,
0.009157932,
-0.0032555372,
0.018524742,
-0.030939844,
0.023655273,
0.007872036,
-0.000849377,
-0.010398137,
0.019973824,
0.059425388,
-0.002496728,
-0.008472556,
0.021292357,
-0.008361591,
-0.0030026007,
-0.013955567,
0.014308046,
0.00664815,
0.008309372,
0.020574342,
0.032193102,
0.00826368,
0.034621295,
-0.012865492,
0.030913735,
-0.0006400925,
-0.006520866,
0.0128981285,
-0.01657958,
-0.0053916266,
0.027206175,
-0.023250574,
-0.04830271,
-0.032114774,
-0.0033093884,
-0.016161826,
-0.009151406,
0.013485595,
-0.0113511365,
-0.039921537,
0.007389009,
-0.0036227033,
0.011227116,
-0.021801494,
0.023877203,
0.01372058,
0.013694471,
-0.0130678415,
-0.018890277,
-0.0021670945,
0.021879822,
0.0065469756,
-0.021240138,
0.018407248,
-0.00007144436,
0.00919057,
0.015156607,
-0.018459467,
-0.0046311854,
-0.019438576,
-0.013929457,
0.018668344,
0.027937243,
-0.039294906,
0.077232115,
0.00036125042,
-0.038146086,
-0.013015622,
-0.0012712098,
0.03107039,
0.0020153327,
0.010672288,
-0.013485595,
0.00013483147,
0.030678747,
-0.010398137,
-0.00035757877,
-0.031514253,
-0.016187934,
0.033289704,
-0.012088732,
0.0098172,
0.0043080794,
-0.0044680005,
0.018198373,
-0.011259753,
0.014556087,
0.0009978752,
-0.029582147,
-0.015261046,
0.023655273,
0.012617451,
-0.00404372,
-0.018263645,
-0.0018782574,
-0.01680151,
-0.043185234,
-0.0013609615,
-0.0054503735,
-0.009073077,
-0.026462052,
-0.03407299,
0.015887676,
0.03159258,
0.01614877,
0.0042950246,
-0.02351167,
-0.03785888,
-0.015104388,
0.010959493,
-0.003687977,
-0.017114826,
0.0038315798
] |
Autosomal dominant polycystic kidney disease (ADPKD) is caused by heterozygous mutations in either PKD1 or PKD2, genes that encode polycystin-1 and polycystin-2, respectively. We show here that tumor necrosis factor-α (TNF-α), an inflammatory cytokine present in the cystic fluid of humans with ADPKD, disrupts the localization of polycystin-2 to the plasma membrane and primary cilia through a scaffold protein, FIP2, which is induced by TNF-α. Treatment of mouse embryonic kidney organ | [
-0.020765759,
-0.006452033,
-0.00042492358,
-0.01919731,
-0.043449953,
0.038057595,
-0.035179947,
0.010531947,
-0.03704653,
0.0060890857,
0.02059725,
0.0070645064,
0.035128094,
0.033054113,
-0.013506818,
-0.01303369,
0.027869154,
0.0044655455,
0.0027626108,
0.002466096,
-0.031887498,
0.03520587,
0.0036359522,
-0.01638447,
-0.0056580864,
0.03082458,
0.01762886,
-0.04267221,
-0.0078941,
-0.05184959,
-0.013079058,
0.0117828185,
-0.0014388261,
-0.0029246407,
0.005661327,
0.01931397,
-0.0052951393,
0.021362029,
0.013908652,
-0.01606041,
0.032976337,
-0.0046340567,
-0.006954326,
-0.014297524,
-0.01114118,
-0.008782024,
0.007505228,
0.0054442068,
-0.01319572,
-0.004420177,
-0.003823907,
0.0017256191,
-0.012605931,
-0.02190645,
-0.008354264,
-0.010052339,
0.0091838585,
0.016371507,
-0.0073302356,
-0.015023418,
-0.004834974,
0.0013707734,
-0.020026904,
0.0060923267,
-0.023656374,
0.016449282,
-0.0009073678,
0.0076348516,
-0.01692889,
0.0023721186,
0.055012412,
0.022373097,
-0.024032284,
-0.017045552,
0.017706634,
-0.03165417,
-0.013506818,
0.020273188,
-0.028050628,
0.010156038,
0.026093304,
-0.022463834,
0.003976215,
0.012217059,
0.026261816,
-0.0011909202,
-0.016397431,
0.009916234,
-0.005884928,
-0.0070321,
0.024395231,
0.023604525,
-0.0027350658,
-0.0054604094,
-0.012878141,
-0.0023996637,
0.0128911035,
0.022152737,
-0.014608622,
-0.03943161,
-0.022593457,
0.0117828185,
0.0031595842,
-0.012605931,
-0.044124,
0.00768022,
-0.0020739834,
0.01173745,
0.015386365,
-0.0018293182,
-0.015567838,
0.0411945,
0.010201407,
-0.019612106,
0.014751208,
-0.007122837,
0.0017013146,
-0.00003189965,
-0.024926689,
-0.004413696,
0.024045246,
0.03953531,
0.0109856315,
-0.00275775,
0.011257841,
0.0070839496,
-0.022463834,
0.010603241,
-0.010881932,
-0.0011949709,
-0.0052173645,
0.030046836,
0.016695566,
-0.01195133,
-0.01834179,
-0.0064455518,
-0.029943136,
-0.021880526,
-0.03232822,
-0.03515402,
-0.0041058394,
0.030798655,
-0.021608315,
0.008036686,
-0.00018258751,
0.029891288,
0.016669642,
-0.00066472794,
0.013228126,
0.019521369,
0.010512504,
0.010298625,
-0.01151709,
-0.019547295,
-0.0011463619,
0.019819506,
-0.013947539,
0.007213574,
-0.011581901,
0.002590859,
-0.01812143,
0.002185784,
0.0046632225,
0.0021161113,
0.049334884,
0.016643718,
0.023617487,
-0.0006307016,
-0.009773647,
-0.007492265,
-0.0054539284,
0.010415286,
-0.012761479,
0.009689392,
0.014180862,
0.0013424183,
-0.0170974,
0.021232406,
-0.029994987,
-0.019365821,
-0.016397431,
0.011043962,
0.027169183,
0.013137389,
-0.011607827,
-0.019015836,
0.031083828,
-0.013973463,
-0.0074404157,
-0.01281333,
0.0058978903,
0.016591867,
0.00024547538,
-0.030798655,
-0.63546854,
-0.03186157,
0.0170974,
-0.0106810145,
-0.017214064,
0.04824604,
0.0037299297,
0.00210963,
-0.01022085,
0.008140385,
-0.012774442,
0.028672822,
0.0055252216,
-0.016786303,
-0.021893488,
-0.025082238,
-0.0032649038,
-0.004883583,
0.028206175,
0.018756589,
0.013325344,
0.0021712014,
-0.008710731,
-0.0026151636,
0.017499236,
0.021582391,
-0.010272699,
-0.007777438,
0.0140642,
0.021478692,
-0.014712321,
0.015671538,
-0.023086028,
-0.0048155305,
0.050968144,
0.0050229286,
0.0043877712,
0.02287863,
0.014919719,
0.048790462,
0.013254051,
0.007304311,
0.032302294,
0.004206298,
-0.017058514,
0.023319352,
0.006831183,
-0.009067196,
0.007220055,
0.0038952003,
0.010719902,
-0.005862244,
-0.03855017,
-0.03227637,
0.008308897,
0.0026362275,
0.026080342,
-0.028361725,
0.013986426,
0.0033475389,
-0.0021922654,
0.042490736,
0.0055025374,
-0.006588138,
0.013817915,
-0.005722898,
-0.014180862,
0.013085539,
-0.006831183,
0.010577315,
0.014725283,
0.04596466,
-0.0031563437,
0.0082764905,
0.020804647,
0.038576093,
-0.008127423,
0.01298184,
-0.013766065,
-0.0055803116,
-0.0019719047,
0.0042808317,
-0.010648609,
0.013908652,
0.029761663,
0.014608622,
-0.020091714,
0.033417057,
-0.0071811676,
0.008017242,
0.022865668,
-0.0250952,
-0.005103944,
-0.034479976,
-0.032043044,
0.0234749,
-0.00870425,
0.014906757,
-0.0019443595,
0.0032730051,
-0.01476417,
-0.019158423,
-0.017589973,
-0.016073372,
0.016643718,
0.0009794711,
-0.03925014,
0.027324732,
0.044098075,
-0.013753103,
0.0008474167,
-0.017914033,
0.010745827,
-0.02584702,
0.014608622,
-0.02059725,
0.008023724,
0.0072459797,
0.025017425,
-0.00013691532,
0.000117269185,
0.0050391317,
0.0133901555,
-0.014608622,
0.00692192,
0.0007631611,
-0.007323754,
-0.006510364,
-0.005846041,
-0.01319572,
-0.007686701,
-0.012508713,
0.0089764595,
-0.01946952,
0.008373708,
-0.025211861,
0.02011764,
0.012327239,
0.0009932437,
-0.021724977,
-0.01563265,
-0.02487484,
0.007770957,
0.0039794557,
0.0016121981,
-0.0007846301,
-0.025185937,
-0.015827086,
0.01514008,
0.000370441,
0.0018455213,
-0.015451177,
-0.0059853867,
0.03909459,
0.0019476002,
-0.013014247,
0.012573525,
0.008957016,
-0.0007129318,
0.004601651,
0.018691776,
-0.01600856,
-0.027143259,
0.0093847755,
-0.011802263,
-0.017654784,
-0.0024288292,
-0.003963253,
-0.00031352797,
-0.021893488,
-0.013169795,
-0.010311587,
-0.03276894,
0.0044655455,
0.00016759973,
0.0042905533,
0.0068441457,
-0.033883706,
-0.0069802506,
0.010175481,
-0.010019933,
-0.03515402,
-0.014103088,
-0.01628077,
0.028906144,
0.017382573,
0.019184347,
0.030954203,
-0.00073521095,
0.050423723,
-0.025769245,
0.017421462,
-0.0059853867,
0.0135975545,
-0.0010693978,
-0.02693586,
0.02688401,
0.013675328,
-0.0042484254,
0.037461326,
0.0055997553,
-0.030902354,
0.01827698,
-0.014660471,
0.038472395,
-0.045342464,
-0.018354753,
-0.009669948,
0.02487484,
-0.0063256496,
-0.01421975,
0.027169183,
0.0015238918,
-0.0008935952,
-0.007220055,
0.029839437,
-0.0017418221,
-0.0151011925,
-0.006960807,
-0.008607032,
-0.023993397,
0.004034546,
0.03287264,
0.0026038215,
0.008697769,
0.007220055,
0.017278874,
0.024900764,
0.020156527,
-0.0170974,
-0.00913849,
0.0187177,
0.011497646,
0.013532742,
-0.015749313,
0.011205992,
0.010771751,
0.014051238,
0.03556882,
0.007829288,
0.003000795,
-0.0060177925,
0.0086524,
0.0049678385,
-0.016552981,
-0.021582391,
0.034583673,
0.030046836,
-0.01600856,
-0.00020061334,
0.0024806787,
0.0038660348,
0.017006665,
-0.008898686,
-0.006121492,
-0.012456863,
0.0234749,
0.0013229746,
0.06310095,
0.015217854,
0.010318068,
-0.016851116,
0.000351605,
-0.009942158,
0.0036521554,
0.007511709,
0.01097915,
-0.014401223,
-0.0004305946,
0.012106879,
-0.03645026,
-0.0020156526,
0.013442005,
-0.04072785,
0.0056094774,
0.019184347,
-0.006176582,
0.0036813207,
0.025535922,
0.019560257,
-0.0040280647,
-0.01211336,
0.0407797,
0.018354753,
-0.010408805,
-0.024784103,
-0.0058039133,
0.00042613878,
-0.010745827,
0.0073431977,
-0.0043262,
0.0069089574,
0.028076552,
0.016915929,
0.007226536,
-0.021504616,
0.016851116,
-0.010713421,
0.0053307856,
-0.009034791,
-0.0018633446,
0.0056872517,
-0.014375298,
0.010972669,
0.015490064,
0.023539713,
-0.001557918,
-0.0007117166,
-0.014712321,
-0.023461938,
0.0173048,
-0.016527057,
-0.011108774,
0.002017273,
-0.018678814,
-0.031057904,
0.0029651483,
0.009598655,
0.034972545,
0.00016020713,
-0.009831978,
-0.020325039,
-0.0028112198,
0.001422623,
0.012236503,
0.032976337,
-0.0048900642,
0.01844549,
-0.0058654845,
0.019962091,
0.0038433506,
-0.015503027,
0.016773341,
-0.020882422,
-0.027221033,
-0.017239988,
0.0053372667,
0.0062284316,
0.010512504,
0.017123327,
-0.005690492,
-0.02309899,
-0.020726873,
0.011964292,
0.010201407,
-0.0027593703,
0.04103895,
0.025717394,
0.0070969122,
-0.008607032,
-0.014336411,
0.017071476,
-0.0036715989,
-0.020338,
-0.022062,
0.018264018,
0.0059367777,
-0.009404219,
0.011154142,
-0.024654478,
0.014725283,
0.015878936,
-0.0054053194,
-0.0040766736,
0.013085539,
-0.0014080404,
0.020338,
-0.00039332773,
0.012009661,
-0.022062,
0.0061863037,
-0.015554876,
0.011730969,
-0.017641822,
0.008853317,
-0.020649098,
-0.009961602,
-0.007770957,
0.030928278,
-0.0035776214,
-0.0047896057,
-0.009669948,
-0.0144919595,
-0.011880036,
0.0075376336,
-0.017201101,
-0.012631856,
-0.02444708,
0.001368343,
0.0005189009,
0.009916234,
0.0035225314,
-0.014077163,
-0.011847631,
0.02168609,
-0.017771445,
-0.010868969,
-0.015477101,
-0.00151417,
0.0087755425,
0.014284561,
-0.0040280647,
0.0086524,
0.019054724,
0.010577315,
-0.028646898,
-0.0030250994,
-0.035024397,
-0.024395231,
-0.0006695888,
-0.016967777,
-0.018419566,
-0.010752308,
0.029683888,
-0.003574381,
-0.025134087,
0.00024162717,
-0.0059724245,
-0.017836258,
-0.00821816,
0.025354449,
0.015658576,
-0.006419627,
0.00486738,
0.009689392,
-0.030435707,
-0.02103797,
-0.033676308,
-0.015762275,
-0.018406603,
-0.0013335065,
-0.004763681,
0.007829288,
-0.018432528,
-0.013675328,
-0.0106874965,
-0.007712626,
-0.01298184,
0.03315781,
0.015049343,
-0.013999389,
0.0025228064,
-0.005797432,
0.009831978,
0.0037493734,
-0.017460348,
0.024135983,
-0.014854907,
-0.021517579,
0.0124892695,
0.00946903,
-0.03028016,
-0.024434118,
-0.0065686945,
-0.018095506,
0.029839437,
0.0021971262,
-0.02996906,
-0.020338,
0.006565454,
-0.022243474,
0.0046599815,
-0.0047669215,
-0.003655396,
-0.015840048,
0.00057196576,
0.010836564,
-0.005359951,
0.005965943,
-0.035776217,
-0.012560562,
-0.00919034,
0.0044461023,
0.012904066,
0.0031757872,
0.0054215225,
-0.011756894,
0.006740446,
0.008347783,
-0.032691166,
0.014647508,
0.00032365485,
0.013947539,
0.0472609,
0.027065484,
0.007673739,
0.029761663,
0.03969086,
0.021050932,
0.01243742,
-0.0018698258,
0.00795243,
-0.023811923,
0.006915439,
0.014453072,
0.014634546,
0.040701926,
-0.02407117,
0.036968756,
0.0125476,
-0.007012657,
-0.00919034,
0.012955915,
-0.030928278,
-0.016721493,
0.010635647,
-0.016734455,
0.00077085756,
-0.034298502,
0.0116856005,
-0.0029829715,
0.0071357996,
-0.003261663,
-0.037383553,
0.022489758,
-0.023773035,
0.015166004,
-0.021374993,
0.006669153,
0.011847631,
-0.015554876,
0.02103797,
0.011776337,
0.01011067,
0.0014185723,
0.017291836,
0.008827392,
0.011588383,
0.012826292,
-0.0015992357,
-0.022450872,
-0.018626964,
-0.008509814,
-0.014103088,
-0.023591561,
-0.01687704,
-0.023137879,
-0.053249527,
0.014660471,
0.020687986,
-0.016306695,
0.007116356,
0.011154142,
-0.027324732,
0.008231122,
-0.024680404,
0.021076858,
-0.013947539,
0.016449282,
0.04223149,
-0.022813817,
-0.00014238383,
-0.016915929,
0.006468236,
0.0018163559,
0.04179077,
0.014090125,
-0.007686701,
-0.0032794864,
0.01054491,
-0.013338306,
-0.014543809,
-0.038913116,
0.016215958,
-0.006290003,
0.004643779,
-0.0020642616,
-0.011828187,
0.0098838275,
-0.011821706,
-0.041842617,
0.0013699633,
-0.027739529,
-0.015153042,
-0.037072454,
-0.0009713696,
-0.015658576,
-0.002417487,
-0.0043553654,
-0.030202385,
0.00021813283,
-0.027480282,
0.01243742,
0.022826781,
0.00057642156,
0.0127874045,
0.010162519,
0.004971079,
0.007090431,
-0.00832834,
0.011277285,
-0.0086524,
-0.026650688,
0.04889416,
-0.009255151,
-0.00600159,
0.014427148,
0.0091838585,
-0.015567838,
-0.015619688,
-0.00924867,
-0.02633959,
-0.031783797,
-0.0018163559,
0.02146573,
-0.00096569856,
-0.008561663,
0.011718007,
-0.03699468,
-0.00019342327,
-0.022152737,
-0.018782513,
0.02547111,
-0.052627333,
-0.01860104,
-0.0012257566,
-0.0006582467,
0.005884928,
0.013986426,
0.004122042,
0.0075376336,
0.02877652,
-0.019767655,
0.003807704,
-0.010311587,
-0.002498502,
-0.021582391,
0.011705045,
-0.016734455,
-0.009365331,
0.012268908,
-0.020234302,
-0.0064293486,
-0.0030218589,
-0.024576705,
0.0077904006,
-0.00034694665,
-0.0046697035,
0.046042435,
0.016047448,
0.024641516,
-0.008885723,
-0.0045984103,
0.022424946,
0.01411605,
0.0012792265,
0.0068895137,
0.0054636505,
-0.009132009,
0.0033540202,
0.0022522165,
0.021180557,
0.007051544,
-0.010868969,
-0.014569734,
0.0149974935,
-0.019728769,
0.0075570773,
-0.0038141853,
-0.0096829105,
-0.02547111,
0.022969367,
0.013137389,
-0.019975053,
-0.012158728,
0.023319352,
-0.019236198,
0.023513788,
-0.020363925,
-0.0044655455,
-0.008432039,
-0.022476796,
-0.033676308,
0.0043132375,
-0.031446774,
0.052653257,
0.014466035,
0.004254907,
-0.0013723938,
0.02212681,
-0.018289942,
-0.016073372,
-0.020363925,
-0.006857108,
0.012716111,
0.031291224,
0.015554876,
0.031498626,
-0.011277285,
0.010272699,
-0.016993701,
-0.011802263,
0.01157542,
-0.009553286,
0.029865362,
0.002660532,
-0.013234607,
-0.026961785,
0.021621278,
0.01865289,
-0.0134938555,
0.035128094,
-0.007887619,
0.019663956,
-0.002022134,
0.010052339,
-0.008205197,
0.008321859,
0.0048058084,
-0.020052828,
-0.0015473862,
0.010130113,
0.0156845,
0.017823296,
0.004284072,
0.0010029655,
-0.02315084,
-0.0040410273,
-0.007492265,
-0.0045076734,
0.0015878936,
0.0039502904,
0.011776337,
0.02709141,
-0.009203302,
-0.008846836,
0.02303418,
0.005489575,
-0.018458454,
-0.008257046,
0.0020642616,
-0.011471721,
-0.0014882452,
0.013364231,
-0.004997004,
0.0009413941,
0.0011941608,
-0.028076552,
-0.02400636,
0.0061668605,
-0.0052108834,
-0.016527057,
0.015282665,
-0.006824702,
-0.0037817792,
0.0011641852,
0.0029359828,
-0.02818025,
-0.010603241,
-0.00045894986,
-0.00400214,
-0.013215164,
-0.010570834,
0.0024677163,
-0.024317456,
0.012832773,
0.012580006,
-0.039924182,
-0.020739835,
0.03352076,
0.20169489,
-0.0069413637,
0.017019628,
-0.004131764,
0.0014177621,
0.004582207,
-0.002817701,
-0.011601345,
-0.016449282,
0.0033054112,
0.008853317,
0.009326445,
-0.009520881,
0.0069996943,
0.022049038,
-0.0063256496,
-0.032691166,
-0.021608315,
-0.017719597,
0.00044031642,
0.00973476,
-0.01924916,
0.008911648,
0.0071033933,
0.037979823,
-0.00041601193,
-0.010032895,
0.0028922348,
0.03575029,
-0.00057318097,
-0.023760073,
-0.015736349,
0.022736045,
-0.01351978,
-0.0052108834,
0.003606787,
-0.02298233,
-0.013221645,
0.0064001833,
-0.0017985326,
-0.02201015,
0.006202507,
-0.030332008,
0.0056710485,
-0.01590486,
0.002503363,
0.0011698563,
-0.029139468,
0.0036845612,
0.0036359522,
-0.034998473,
-0.00088873436,
0.031057904,
0.0132864565,
-0.011290248,
-0.004099358,
0.0117893,
0.023448976,
-0.009449587,
0.036113236,
0.019663956,
0.023967471,
-0.046638705,
0.013584591,
-0.027895078,
0.033831857,
-0.026624763,
-0.004141486,
0.0035938246,
-0.03549104,
-0.000010924364,
-0.032976337,
-0.00092600123,
-0.008347783,
0.012722593,
-0.009922715,
0.015969673,
0.039327912,
0.013662366,
0.024330419,
0.0053243046,
0.003940569,
-0.01119303,
-0.0060113114,
-0.021543503,
-0.017395537,
0.0069672884,
0.0047118315,
-0.004371568,
-0.0075635584,
0.008257046,
-0.01827698,
0.00832834,
0.0014372057,
0.02547111,
0.0034998471,
0.005055335,
-0.019443596,
-0.01687704,
-0.017667746,
-0.025004463,
0.058849283,
0.0063191685,
0.005440966,
-0.013882727,
0.0010839804,
-0.0022295322,
0.012035585,
0.011938367,
-0.010570834,
-0.0016737694,
-0.018419566,
0.01628077,
-0.012093917,
0.0014890553,
0.035879914,
0.012644818,
-0.020039866,
0.0013294559,
0.0067015593,
-0.0018665851,
-0.038109448,
0.022321247,
0.018471416,
-0.02103797,
0.00962458,
-0.015827086,
-0.0037396515,
-0.0026572912,
-0.063256495,
0.016202996,
-0.01130321,
-0.009689392,
0.0074533783,
0.011050443,
-0.009974564,
0.014971568,
-0.014271599,
-0.008665362,
0.025859982,
-0.0050585754,
0.007148762,
0.011763375,
0.023669336,
0.00930052,
-0.020234302,
0.019456558,
-0.005327545,
-0.008393152,
-0.017667746,
-0.022943443,
-0.025134087,
-0.008853317,
-0.006231672,
0.013117946,
-0.024926689,
-0.013662366,
-0.028543198,
-0.0037234484,
0.0039243656,
-0.016228922,
0.019054724,
0.008159828,
0.004196576,
0.0043262,
-0.015593763,
-0.16114852,
0.0065136044,
0.00063110667,
-0.004582207,
0.013377193,
0.015062305,
-0.0058265976,
-0.0061636195,
0.019910242,
-0.021374993,
0.027169183,
0.0024207276,
-0.008347783,
0.0056969733,
0.027298808,
0.00038198562,
-0.00935885,
0.04640538,
0.0072006113,
0.01329942,
0.027713604,
-0.024810027,
0.024810027,
-0.009462549,
-0.009326445,
0.02477114,
0.004011862,
-0.023021217,
-0.034168877,
-0.008289453,
-0.005152553,
0.0069996943,
0.015023418,
0.008626475,
0.011549495,
-0.013182757,
-0.005700214,
-0.01146524,
0.019832468,
0.0188214,
0.019663956,
0.038472395,
0.047079425,
0.0050747786,
-0.025393335,
0.037020605,
-0.014880831,
-0.011199511,
0.01822513,
0.0032892083,
0.03849832,
0.0022619383,
0.017330725,
0.009170895,
0.032354143,
0.019028798,
0.0017337205,
0.013351269,
-0.012767961,
-0.0032049527,
-0.011355059,
0.011063405,
0.02265827,
0.007615408,
0.004818771,
-0.018017732,
0.004462305,
0.012126322,
-0.024473006,
0.006954326,
-0.024758179,
-0.016682604,
0.014051238,
0.0054604094,
0.01070694,
-0.0075376336,
-0.013584591,
0.0073367166,
0.009196821,
-0.021232406,
-0.03494662,
-0.00935885,
-0.022243474,
-0.01784922,
-0.018419566,
0.009857902,
-0.019301008,
0.01438826,
-0.010551391,
-0.013740141,
0.0017758483,
-0.018989911,
0.011180067,
-0.0043618465,
0.010642128,
0.026572913,
-0.005965943,
0.004309997,
-0.023708224,
0.013558667,
0.00784225,
-0.014401223,
0.0026589117,
0.016565943,
0.048660837,
-0.0011674259,
0.0032324977,
0.008043167,
0.029217243,
-0.0063450933,
0.007848731,
0.0064455518,
0.005214124,
0.014738245,
0.0076996638,
0.019041762,
0.008341302,
0.014621584,
0.010039376,
-0.041350044,
0.078655824,
0.008827392,
0.019210272,
0.0031190768,
0.010143075,
-0.007187649,
-0.12143173,
-0.018043656,
0.0033572607,
0.010849526,
-0.0074404157,
-0.0053631915,
-0.0031304187,
0.025898868,
-0.02022134,
0.03759095,
-0.016034484,
-0.00502941,
0.0014825742,
-0.019456558,
0.020234302,
-0.007712626,
0.04007973,
-0.001562779,
-0.023137879,
0.02606738,
-0.015153042,
0.0060696425,
0.018108469,
-0.023293426,
-0.023643412,
-0.011873555,
-0.059989974,
0.011270804,
0.012106879,
0.009929196,
0.01503638,
-0.0053437483,
0.00843852,
-0.007816325,
-0.02828395,
-0.013312382,
-0.012255946,
-0.01924916,
0.037927974,
-0.015593763,
0.0029392235,
-0.011134699,
0.019780617,
0.00031332544,
0.010285662,
-0.0054928157,
-0.028024701,
-0.0021938856,
0.03445405,
-0.030383859,
-0.04580911,
-0.022113848,
-0.025782207,
0.009164414,
-0.0013675329,
-0.022567533,
-0.000011626916,
0.03173195,
-0.013364231,
0.015282665,
-0.008347783,
-0.0068117394,
0.0094107,
-0.001157704,
-0.01914546,
-0.012353164,
-0.021271294,
-0.045238763,
0.0077385507,
-0.030591257,
-0.008406115,
-0.018614002,
-0.010648609,
-0.014699358,
-0.014077163,
0.018588077,
-0.018367717,
-0.00063191686,
0.014414186,
-0.012949434,
-0.010933782,
-0.003960012,
0.024576705,
-0.021336105,
0.008632956,
0.015840048,
0.010726383,
-0.0073367166,
0.008432039,
-0.015321553,
-0.025185937,
0.013623479,
0.0080755735,
0.005645124,
-0.018562153,
0.010538429,
0.023617487,
-0.00887276,
0.014712321,
0.02066206,
-0.026326628,
-0.02487484,
-0.058227085,
0.017875144,
0.0006934882,
0.00020861358,
-0.0100782635,
0.000020595528,
-0.000034811124,
-0.00049945735,
0.014362335,
0.015334516,
-0.014517885,
0.007608927,
-0.005781229,
-0.0021161113,
-0.025354449,
0.0058395597,
0.01919731,
0.019288046,
0.001092892,
0.017589973,
-0.009417181,
0.020104678,
0.008710731,
0.021608315,
0.008619994,
-0.026650688,
-0.018315867,
0.015865974,
0.006539529,
-0.0021971262,
0.010207888,
-0.028491348,
-0.0025989607,
0.00849037,
0.008127423,
-0.011108774,
0.008944054,
0.018834362,
0.0135975545,
0.0411945,
-0.0010199785,
-0.043190707,
0.017589973,
-0.018536227,
-0.0053988383,
-0.0005800673,
-0.033287436,
0.011666157,
-0.016773341,
-0.0064293486,
0.038161296,
0.008457964,
0.006539529,
-0.0029278814,
-0.029761663,
-0.00008967346,
0.019858392,
-0.028828371,
-0.005152553,
-0.012605931,
0.008185754,
0.007284867,
0.002357536,
-0.0030753287,
0.0015133598,
0.0010280801,
-0.031913422,
0.0045789666,
0.0054280036,
-0.03600954,
-0.01600856,
0.014323449,
0.010097707,
0.014427148,
0.003872516,
-0.00018380274,
-0.025108162,
-0.0030575052,
-0.010421767,
0.021245368,
0.0057682665,
-0.0015603486,
-0.025769245,
0.005035891,
-0.00086442987,
-0.021763865,
-0.0066950778,
0.012929991,
0.020765759,
0.018458454,
-0.029424641,
0.010758789,
-0.01329942,
0.020299114,
0.006079364,
0.016021522,
-0.005771507,
-0.024615591,
-0.0049127485,
0.036476184,
0.003060746,
-0.026521064,
-0.0025373893,
-0.011296729,
-0.014025314,
0.015878936,
-0.03943161,
-0.03077273,
-0.0064487923,
-0.0053793946,
0.012929991,
0.016034484,
0.0009381535,
0.0067210025,
-0.006558973,
0.011588383,
0.004066952,
-0.015295628,
0.011218955,
0.011607827,
0.010512504,
0.014608622,
-0.007712626,
0.014530847,
-0.0041512074,
0.001991348,
0.03152455,
-0.015347478,
0.030435707,
-0.0069996943,
-0.0048284926,
0.008030205,
-0.020908346,
0.0111865485,
-0.011128218,
-0.01979358,
0.013377193,
0.021945339,
-0.017538123,
0.08062611,
-0.0010337512,
-0.020908346,
0.018614002,
-0.013027209,
-0.0022311525,
-0.011536533,
0.009242189,
-0.006257597,
-0.029657964,
0.0031401406,
-0.010700459,
0.02487484,
-0.024434118,
-0.021556465,
0.008451482,
0.0026994192,
-0.028335799,
0.004284072,
-0.007576521,
0.025406297,
0.010285662,
-0.0068765515,
0.031317152,
-0.023695262,
-0.017058514,
0.049853377,
0.009332926,
0.025237786,
-0.02131018,
-0.012469825,
0.0046956283,
-0.021452766,
-0.019223234,
0.017278874,
-0.01498453,
0.00913849,
-0.00032183202,
-0.004472027,
-0.002952186,
0.0032000917,
0.02223051,
-0.004309997,
-0.016358545,
0.0067469277,
-0.021115744,
-0.011329135,
-0.011549495,
-0.024693366
] |
Inefficient inhaler technique is a common problem resulting in poor drug delivery, decreased disease control and increased inhaler use. The aim of this study was to assess patients' use of different inhaler devices and to ascertain whether patient preference is indicative of ease of use and whether current inhaler use has any influence on either technique or preference. We also wished to define the most appropriate method of selecting an inhaler for a patient, taking into account observed technique and device cost. One hundred patients received instruction, in randomized order, in the use of seven different inhaler devices. After instruction they were graded (using predetermined criteria) in their inhaler | [
-0.02032763,
0.027601538,
0.01804716,
-0.019803382,
0.007496714,
0.028492756,
-0.009200513,
-0.015609417,
-0.025452131,
-0.015622524,
-0.009495401,
0.011304049,
0.027575327,
0.029252913,
0.0074180774,
-0.003882695,
0.044089068,
-0.011402345,
0.004629745,
-0.008401038,
-0.023158556,
0.02079945,
-0.015465249,
-0.017418064,
-0.021638243,
-0.0040792874,
0.020131037,
-0.033735216,
-0.010242451,
-0.0075163734,
0.003099603,
0.021743093,
-0.009862374,
-0.022752266,
-0.032057628,
-0.025583193,
0.007627776,
-0.009999988,
0.0065891137,
-0.019973762,
0.0153604,
-0.008184787,
0.018781103,
0.008571418,
-0.020445583,
0.019279137,
0.007483608,
0.00033420668,
-0.033053696,
0.005881382,
0.0061402284,
-0.015910858,
-0.008846647,
0.001962645,
0.0022575334,
-0.011933144,
-0.0041546477,
0.009226725,
0.005458709,
-0.037142813,
-0.04070768,
0.0010108113,
-0.009849267,
0.0007941504,
-0.008958049,
0.014980323,
0.002463955,
0.008650055,
0.019148076,
-0.012057653,
0.028571393,
0.02284401,
-0.008591077,
0.017116623,
0.007863686,
0.011625149,
0.0018938378,
-0.0109239705,
0.012483602,
0.032477025,
0.014744412,
-0.0075753513,
-0.0024737846,
0.02671032,
-0.0018512429,
0.0059010414,
0.016225407,
0.014220166,
0.00081462873,
-0.0032945569,
0.00060247304,
0.014849261,
0.017863674,
0.01570116,
-0.0099213505,
0.02216249,
0.0028423949,
0.009836161,
0.013112697,
-0.035150677,
-0.008925284,
-0.0033224074,
-0.020943617,
-0.007667094,
-0.025937058,
0.009849267,
-0.019226713,
-0.017522914,
-0.002945606,
-0.03507204,
0.0042627733,
0.047051057,
-0.010648741,
0.0004320932,
0.0153472945,
-0.032214902,
0.003735251,
-0.023564847,
0.0018119244,
-0.024220154,
0.0036467845,
0.021087786,
0.022005215,
-0.02647441,
0.0050688013,
-0.017719507,
-0.040760107,
0.015032747,
0.0004083383,
0.008473122,
0.026055014,
0.007542586,
0.038532063,
-0.0099213505,
-0.027549114,
0.019685429,
0.00750982,
-0.017522914,
-0.015307976,
-0.016631696,
-0.008250318,
0.005937083,
-0.0055537284,
-0.020445583,
-0.0023885947,
0.034547795,
0.03929222,
0.017208368,
-0.011212306,
0.012024887,
-0.02450849,
-0.003374832,
-0.0018299454,
-0.01512449,
0.01879421,
0.013774557,
-0.020026188,
0.019960657,
-0.01252292,
-0.0031471127,
-0.003656614,
-0.015032747,
0.00610091,
-0.010294876,
0.01695935,
0.012804703,
-0.0059338068,
-0.007365653,
0.030406253,
0.009076005,
-0.010137603,
0.0027981617,
-0.013020954,
0.01169068,
0.008355167,
-0.003160219,
0.004315198,
0.011317155,
-0.0034338096,
-0.02032763,
-0.011238518,
0.03276536,
0.02450849,
-0.001473622,
-0.027182141,
-0.0059698485,
0.015307976,
0.025465237,
0.00401048,
-0.029200489,
0.02252946,
0.010937077,
-0.021179529,
-0.003728698,
-0.6416768,
-0.015556993,
0.006536689,
-0.000078688056,
0.0126933,
0.02188726,
0.015937071,
0.008112703,
0.0105045745,
0.023787651,
0.008925284,
0.0018102861,
0.00776539,
-0.010537339,
-0.0085845245,
-0.017955417,
-0.009783736,
-0.01998687,
0.017588444,
-0.016867608,
-0.011579278,
0.01617298,
-0.025819104,
0.008617289,
-0.008499335,
0.01009173,
0.0077784965,
-0.0063302675,
0.009305362,
0.0020248992,
0.009554379,
0.022830902,
0.021847941,
-0.0019642834,
0.048754856,
-0.010642189,
-0.009036686,
-0.0035321058,
0.02888594,
0.0074901613,
-0.036277805,
-0.023171661,
0.03229354,
-0.010373513,
-0.0011844677,
0.0034698516,
0.003111071,
0.012070758,
0.021153316,
-0.014941004,
0.012149395,
-0.004695276,
0.0032667064,
0.019829595,
0.029960645,
0.00048451775,
0.004334857,
-0.009862374,
0.0101441555,
-0.004138265,
0.002237874,
0.012968529,
-0.025766678,
-0.021874154,
-0.02267363,
0.00985582,
0.0031192622,
-0.012712959,
-0.009724759,
-0.03344688,
0.018951483,
0.018741786,
-0.011920038,
0.0074901613,
0.0052260747,
0.0048689325,
0.008735245,
-0.013604177,
-0.0047116587,
-0.007857134,
-0.011487535,
0.028833516,
-0.021127103,
-0.004675617,
0.031533383,
0.0030127747,
-0.0067168986,
0.008813881,
-0.010648741,
-0.0085583115,
0.020340735,
0.015281764,
0.0056028767,
-0.03507204,
-0.011120563,
0.019082546,
-0.009331575,
-0.017522914,
0.014823048,
-0.01648753,
-0.0200524,
0.0039580553,
0.0001700727,
0.011651362,
0.004384005,
0.023342041,
-0.008414145,
0.0044495356,
0.031585805,
-0.021913473,
0.01352554,
-0.009986881,
0.012483602,
0.006326991,
0.029829584,
-0.025334176,
0.008617289,
0.011441664,
-0.024075987,
-0.03871555,
0.0016210661,
-0.039737828,
0.010124496,
0.0026883977,
-0.010976396,
0.006307332,
-0.013512434,
0.0029144788,
-0.0052555637,
-0.021965897,
0.0056159827,
-0.015727373,
0.016304042,
-0.004970505,
0.005937083,
0.01111401,
0.01292921,
-0.01668412,
0.0060878037,
-0.036225382,
-0.010491468,
0.012241138,
0.011821741,
-0.00054841023,
-0.0023902329,
-0.026081227,
-0.0015448867,
0.0016423636,
0.0026982273,
0.008125809,
0.007752284,
-0.026736533,
-0.0063138846,
0.022096958,
-0.00021522745,
-0.0075753513,
-0.01900391,
-0.03703796,
-0.029724734,
-0.025845315,
0.005832234,
0.013047166,
-0.02783745,
-0.01971164,
-0.019069439,
-0.0135386465,
0.0021674286,
0.0067955353,
0.0010919056,
-0.040524196,
0.011297496,
0.0047837426,
-0.0061303987,
0.03929222,
-0.0121756075,
0.012477049,
-0.00910877,
-0.018728679,
0.0066054966,
-0.016906926,
0.0046854466,
0.007542586,
0.018728679,
0.0004812412,
0.007975088,
-0.016749652,
0.008833541,
0.0010951821,
-0.01100916,
0.019790277,
-0.0013106144,
-0.016356468,
-0.00089039863,
0.01947573,
0.0021018977,
0.0058781053,
0.021979002,
0.011231965,
-0.01648753,
0.012391859,
0.043512397,
-0.0007855495,
0.008669714,
-0.0099475635,
0.03771948,
-0.01845345,
0.011002608,
-0.0063237143,
0.026998656,
0.010484915,
-0.011448217,
0.0007908739,
0.0014048148,
-0.014796836,
-0.021153316,
0.0059436364,
-0.005085184,
0.045085136,
0.01235254,
-0.0026982273,
-0.016277831,
-0.013577965,
0.029043214,
-0.0034370862,
-0.01252292,
0.0032683446,
-0.002524571,
-0.011684127,
0.040288284,
-0.016159875,
-0.008735245,
0.003361726,
0.020235887,
0.0016857778,
0.027575327,
0.044246342,
0.014403652,
-0.00408584,
0.046159837,
0.00759501,
0.018676255,
0.004560938,
-0.0008301923,
-0.017208368,
0.010045859,
0.035019618,
0.028781092,
-0.011906931,
-0.0050688013,
0.013433797,
0.011697234,
-0.011225413,
0.004944293,
-0.018335495,
-0.01678897,
-0.02854518,
0.02749669,
0.002072409,
0.01604192,
0.021874154,
0.024967205,
0.013905618,
0.021559607,
-0.01094363,
0.022568779,
0.0016374488,
-0.01730011,
-0.006736558,
-0.0017037987,
-0.011441664,
-0.021729987,
-0.01597639,
0.016408892,
-0.023014389,
0.023591058,
0.014403652,
-0.020471796,
0.006634985,
0.022241127,
0.024207048,
-0.020484902,
-0.02419394,
0.0077326247,
0.009646121,
0.016775863,
-0.00058117555,
-0.031821717,
0.018073373,
-0.025019629,
0.020943617,
0.0017087135,
0.0013736876,
0.015268657,
-0.008820435,
0.010910865,
-0.0013966234,
0.027627751,
0.004482301,
-0.000044284432,
0.008387932,
0.020825662,
-0.007739178,
-0.013564859,
-0.014587138,
0.043617245,
0.014809943,
-0.02314545,
-0.03048489,
-0.0014908238,
0.006494094,
-0.0047051054,
-0.019108757,
-0.0066186027,
0.007300122,
0.010491468,
0.021166421,
-0.02331583,
0.0004988526,
0.026723428,
-0.017287003,
0.0049377396,
-0.011874166,
0.022608098,
0.0062319716,
0.033630364,
0.011887273,
-0.0014621542,
0.038820397,
0.001326178,
-0.011041926,
-0.013040613,
-0.029305337,
0.016133662,
0.0027604816,
-0.010065518,
-0.010045859,
0.033630364,
-0.0090039205,
0.007083871,
0.014809943,
0.00065940287,
-0.0080013005,
-0.02171688,
-0.016055027,
-0.0034829576,
0.009397105,
0.018938377,
-0.006480988,
0.0058551696,
-0.0053964546,
0.018256858,
0.0146526685,
0.012555686,
0.022096958,
-0.0029128406,
0.020589752,
-0.0029505207,
0.038217515,
-0.015203127,
-0.0007146944,
-0.0077784965,
0.010819121,
0.010203133,
-0.0022657246,
-0.0053767953,
0.005868276,
0.007011787,
0.011559619,
0.0036402314,
-0.019842701,
-0.0075884573,
0.005337477,
-0.008794222,
-0.0356225,
0.02967231,
-0.028256847,
-0.009226725,
-0.023342041,
0.0068807253,
0.01930535,
-0.0014228357,
-0.01866315,
-0.015255552,
-0.0153472945,
-0.020681495,
-0.02015725,
0.017247684,
-0.011671021,
-0.032712936,
-0.036120534,
-0.03368279,
-0.025347281,
-0.0011091074,
-0.0045805974,
-0.0028767986,
-0.009383999,
-0.016461316,
0.0055111335,
0.0013564859,
0.022136277,
0.013047166,
0.01211663,
0.018335495,
0.019895127,
-0.00333879,
0.019934446,
0.0012237862,
-0.023184769,
-0.00089531345,
0.0099213505,
-0.027444266,
-0.023420678,
-0.021939686,
0.011245071,
0.021533394,
-0.01563563,
0.011297496,
-0.0095871445,
0.0076015634,
0.015294869,
0.013761451,
0.013761451,
-0.012359094,
-0.02566183,
0.008591077,
-0.018335495,
-0.0078047086,
-0.012391859,
0.02348621,
0.011343367,
-0.004397111,
-0.009043239,
0.015727373,
-0.00200524,
-0.0077064126,
-0.018545194,
-0.015779797,
-0.012935764,
0.029174276,
0.043040577,
-0.02956746,
0.024757506,
0.011238518,
0.010589764,
-0.007182167,
-0.010327641,
0.022044534,
0.019908233,
-0.013774557,
0.023931818,
-0.011526854,
-0.02566183,
-0.059554316,
0.0056520244,
-0.0029750946,
0.037771907,
0.01320444,
-0.029541248,
-0.056566115,
-0.0045707677,
-0.0111729875,
-0.0066906866,
-0.014364334,
-0.043250274,
-0.011225413,
-0.0025114648,
-0.0139842555,
-0.0018053713,
0.034888554,
-0.017522914,
-0.0070642116,
0.014967216,
-0.027365629,
-0.008217552,
-0.019344669,
0.010589764,
-0.019724747,
-0.026120545,
-0.036199167,
-0.030982925,
0.0006979022,
-0.0068741725,
0.011651362,
0.029383974,
0.016107451,
-0.016526848,
-0.020248992,
0.0049508456,
-0.005923977,
0.01218216,
-0.0130144,
-0.0057699797,
-0.011428557,
0.026277818,
0.01634336,
-0.015884647,
0.024796825,
-0.00851244,
-0.010078625,
-0.03976404,
-0.010307982,
-0.005403008,
-0.023866288,
-0.03035383,
-0.012378753,
-0.0049082506,
0.0060321027,
-0.012418071,
-0.05604187,
0.00020375958,
0.0043184743,
0.0075753513,
-0.007378759,
-0.015425932,
0.0030340722,
-0.0040203095,
0.014416758,
0.02250325,
-0.0012786682,
-0.026775852,
-0.0016366297,
-0.028781092,
-0.012935764,
-0.00684796,
0.007300122,
0.0016030453,
-0.0076933065,
-0.0029324996,
-0.0162123,
0.011461323,
-0.010353854,
0.0026556323,
-0.01109435,
-0.025019629,
-0.00825687,
-0.027522901,
-0.0059010414,
0.0074049714,
0.012260797,
0.021100892,
0.003971162,
0.019672321,
-0.030878074,
0.010897758,
-0.0051277787,
-0.00927915,
0.00081176177,
-0.00576015,
0.03035383,
0.015425932,
-0.035832196,
-0.024220154,
-0.0035943598,
0.020380054,
-0.01478373,
0.027182141,
0.01937088,
0.0004517524,
-0.017391853,
-0.00045011414,
-0.0011582555,
-0.022608098,
-0.021467863,
0.032608084,
0.01226735,
0.015045853,
-0.0013548476,
-0.03195278,
-0.029279126,
0.03460022,
-0.0005447241,
0.015609417,
-0.025740467,
-0.0063564796,
-0.006926597,
0.011592384,
-0.0025278474,
0.014220166,
0.0060255495,
0.013905618,
-0.011035373,
-0.011900378,
-0.029882008,
0.0048066783,
0.010543893,
-0.009423317,
-0.0034370862,
-0.004357793,
0.003928567,
0.02498031,
-0.008381379,
0.0014392184,
-0.01094363,
0.032870207,
0.0033289606,
-0.006418734,
0.013840088,
-0.043381337,
0.006382692,
-0.016369574,
-0.01838792,
-0.019462623,
0.026631685,
0.006834854,
0.01845345,
0.018741786,
-0.014154635,
-0.01736564,
-0.00090678135,
0.0058584465,
0.022581887,
-0.013125803,
0.0162123,
-0.03368279,
-0.0033158544,
-0.0061893766,
-0.012490155,
-0.008813881,
0.0034010443,
-0.0035222762,
0.008715586,
0.019108757,
-0.017929204,
-0.009115323,
0.022005215,
0.006510477,
0.0011951164,
0.021074679,
-0.026723428,
-0.017955417,
-0.0001080233,
-0.003905631,
-0.028728668,
-0.0077784965,
-0.013918725,
-0.0062024826,
-0.0047051054,
0.016749652,
-0.004547832,
0.019383987,
0.022175595,
0.0004292262,
-0.020707708,
0.016159875,
-0.03564871,
0.015832221,
0.039816465,
-0.033840064,
0.001613694,
-0.01631715,
0.039161157,
0.011677574,
-0.036146745,
-0.0013417414,
-0.031323683,
0.022437718,
-0.017889887,
-0.008564865,
-0.006821748,
0.012961976,
-0.026697215,
0.0063433736,
0.0060550384,
0.01903012,
-0.0013966234,
-0.022044534,
-0.004518343,
0.015923964,
-0.034993403,
-0.0098099485,
0.00667758,
0.011336815,
-0.01896459,
-0.0064580524,
-0.007909558,
0.038794186,
0.010307982,
-0.013007848,
-0.03266051,
-0.026998656,
-0.05703794,
0.017771931,
-0.01655306,
0.016251618,
-0.032267325,
0.014993428,
-0.008551759,
0.016946243,
-0.009180854,
-0.0003090183,
-0.021769306,
-0.02933155,
0.024888568,
-0.00934468,
-0.0177064,
-0.016002601,
-0.028020935,
0.0054193903,
0.025740467,
-0.008754904,
-0.012883339,
0.031454746,
0.01277849,
0.012477049,
0.0024115304,
0.032162476,
-0.009836161,
0.008650055,
0.002078962,
-0.0038663123,
0.006756217,
-0.009325021,
-0.0075884573,
-0.00601572,
0.0071494016,
0.001387613,
-0.010465256,
-0.017745718,
0.007981641,
-0.024836142,
-0.026448198,
-0.017680189,
-0.0056127063,
-0.013394479,
-0.01631715,
0.0028456715,
-0.020235887,
-0.015085172,
-0.0007024074,
0.0077064126,
0.018112691,
0.013112697,
0.016644802,
-0.01695935,
-0.022712948,
0.01369592,
0.01699867,
0.00451179,
-0.008217552,
-0.0036729968,
0.0013433797,
0.0011451493,
-0.0050720777,
0.0025753572,
0.014626456,
0.020262098,
-0.009154641,
-0.0036041895,
-0.0034567455,
-0.025478344,
0.033210967,
-0.038086455,
0.030275192,
-0.03231975,
-0.036618564,
0.02583221,
0.014351227,
0.0077064126,
0.00059264345,
0.018112691,
0.19512427,
-0.019174289,
-0.0088925185,
0.031323683,
0.0010476724,
-0.0076474347,
0.040891167,
-0.010786356,
-0.029515035,
0.01719526,
0.026592366,
-0.006438393,
-0.021533394,
0.00070937,
0.021048468,
0.0050393124,
-0.024796825,
-0.0123132225,
0.0057110023,
0.036959324,
-0.015950177,
-0.004629745,
0.02933155,
0.004354516,
0.03310612,
0.00047919338,
-0.008348614,
0.0036631671,
0.0036041895,
0.024390534,
-0.02854518,
-0.012450837,
0.008610737,
0.021127103,
-0.020917406,
-0.0036074661,
0.017182155,
-0.014482289,
-0.012136289,
0.018505875,
0.003374832,
-0.0005955104,
-0.0015522589,
-0.007903005,
0.0023574675,
0.022005215,
0.005868276,
-0.003882695,
-0.010530787,
-0.021559607,
0.012431177,
-0.011697234,
0.015085172,
0.018571407,
-0.008053726,
0.0032306644,
0.009318468,
0.0129816355,
0.022280445,
-0.015465249,
0.0052653933,
0.0068020886,
-0.002054388,
0.013971149,
-0.01896459,
0.03323718,
-0.028807305,
-0.0142070595,
-0.0144298645,
0.008643501,
0.014705094,
0.01964611,
-0.016815182,
0.032608084,
-0.037169024,
-0.023263406,
0.037640844,
0.017863674,
0.017902993,
0.017339429,
-0.023446891,
0.018545194,
-0.034154613,
-0.017522914,
-0.017758824,
-0.046369538,
-0.0014310271,
0.007280463,
-0.019633003,
0.01192659,
-0.026946232,
-0.014141529,
-0.016133662,
-0.0065072,
0.035674922,
0.0047345944,
0.0185583,
-0.01838792,
0.0041186055,
-0.00093708927,
-0.020851875,
0.05614672,
0.003912184,
0.005861723,
0.004439706,
0.016697228,
-0.014351227,
0.014456077,
0.010982948,
-0.003332237,
0.041284353,
-0.039580554,
0.01947573,
-0.02515069,
0.004560938,
0.021874154,
0.0118414005,
-0.029986857,
-0.0050688013,
-0.015150703,
0.0037090387,
-0.011847954,
0.003643508,
0.028335484,
0.010052413,
0.0043250276,
-0.024836142,
0.023866288,
-0.017064199,
0.0033174925,
0.0046625105,
-0.009744418,
0.016133662,
-0.011900378,
-0.023944926,
0.002445934,
-0.009495401,
-0.024246367,
-0.009351234,
-0.027758813,
0.021533394,
-0.0041841366,
0.018610723,
0.023433786,
0.02990822,
-0.0019610068,
0.0177064,
0.008787669,
0.010714273,
-0.02022278,
-0.008460016,
-0.0085845245,
0.017155942,
-0.031664442,
0.036959324,
-0.02653994,
-0.010556999,
0.010150708,
0.014049786,
0.02314545,
-0.007726072,
0.0019364328,
0.023682801,
-0.0022051088,
-0.0065203067,
0.008787669,
-0.16398408,
0.023709014,
0.035203103,
-0.028938366,
0.024587126,
-0.025884634,
0.042804666,
0.0013671346,
-0.015622524,
-0.016264724,
0.014993428,
0.032843996,
0.0033781086,
-0.009200513,
0.013446904,
-0.0012090418,
-0.011055033,
0.018754892,
0.02589774,
0.002023261,
0.032503236,
-0.009161195,
0.017077306,
0.00066923245,
-0.0030176896,
-0.0003362545,
-0.047732577,
0.00750982,
0.0050131,
-0.010661848,
-0.016841395,
0.00643184,
0.040969804,
-0.0036172958,
0.0048754853,
-0.01587154,
0.015085172,
-0.00012430358,
0.008944944,
0.020550434,
0.02429879,
0.031349897,
0.017457383,
-0.0012606472,
-0.0062680133,
-0.011231965,
0.032948844,
0.004845997,
0.0100589655,
0.0021166422,
0.0162123,
0.0027801408,
-0.018374814,
0.00417103,
0.011461323,
-0.015032747,
-0.0049410164,
0.018099584,
0.0043676225,
-0.011572725,
0.012005228,
-0.037431147,
-0.014049786,
0.006834854,
-0.007051105,
0.002495082,
-0.011363027,
-0.0009444615,
-0.0021608754,
0.016290937,
-0.035360377,
-0.012398412,
0.019148076,
0.016277831,
0.029593673,
0.018741786,
0.0010124496,
0.016710334,
0.016461316,
-0.003600913,
-0.007208379,
0.019121863,
-0.003826994,
-0.008099597,
-0.02103536,
0.021612031,
-0.007221485,
-0.001168085,
-0.018990802,
-0.0031012413,
0.026500624,
-0.02786366,
-0.020589752,
-0.011035373,
-0.007542586,
0.0277326,
0.029436398,
-0.023276512,
0.013630389,
0.0017480319,
-0.015229339,
-0.0023001283,
-0.010013094,
0.02521622,
0.017273897,
-0.012798149,
-0.018505875,
0.002439381,
0.03483613,
-0.004439706,
-0.03633023,
0.0025999313,
0.0004206253,
0.0025704424,
-0.019423306,
0.022542568,
0.008715586,
0.0014228357,
0.022726053,
-0.022581887,
0.039895102,
-0.00994101,
-0.008571418,
0.023709014,
0.0034501923,
-0.019318456,
-0.12403654,
-0.030904287,
0.050720777,
0.0106159765,
-0.0080275135,
0.008912178,
0.0035058935,
0.024967205,
-0.014888579,
0.042673603,
-0.01964611,
-0.009934457,
-0.005373519,
-0.024849249,
0.020996042,
-0.004128435,
0.010209686,
-0.048781067,
-0.005825681,
0.02052422,
0.0062581836,
-0.0061402284,
0.010576658,
-0.0018086479,
-0.010203133,
-0.014862367,
-0.00910877,
0.010714273,
0.013197887,
-0.007306675,
0.04230663,
0.012070758,
-0.005006547,
-0.014927898,
-0.0024000625,
0.0077916025,
-0.0048951446,
-0.015268657,
0.045766655,
-0.03630402,
0.010851887,
0.022096958,
0.009469189,
0.0133158425,
0.0055701113,
-0.006608773,
-0.030537315,
0.004230008,
-0.020078612,
-0.0036729968,
-0.028781092,
-0.035491437,
-0.03837479,
-0.0071166363,
-0.0016407254,
-0.012391859,
0.019148076,
0.0004093622,
-0.0042922623,
0.012699854,
-0.01617298,
0.005134332,
-0.024587126,
0.04332891,
0.0037876756,
-0.031113986,
0.012529474,
-0.008453463,
-0.015845329,
-0.0034338096,
-0.019554367,
0.02182173,
-0.006425287,
0.015412825,
-0.03171687,
-0.03530795,
-0.0016923308,
-0.015792903,
0.0007531937,
-0.0078898985,
-0.017103517,
-0.0055275164,
0.010249005,
-0.023407573,
0.015674949,
0.017601551,
0.013106144,
0.013086485,
0.002323064,
-0.02515069,
-0.010956736,
0.030065494,
-0.010203133,
-0.011336815,
-0.017994735,
0.018256858,
-0.021598926,
-0.0060255495,
-0.0015104831,
0.019934446,
0.016762758,
-0.0183486,
-0.03598947,
0.009410211,
0.023787651,
-0.002316511,
0.005196586,
-0.011041926,
0.035255525,
0.01638268,
-0.0041546477,
-0.003987544,
-0.022752266,
0.0028620542,
0.0033944913,
0.0036795498,
-0.015858434,
-0.008453463,
0.015609417,
-0.00009158942,
-0.002501635,
0.00085353764,
-0.0024918057,
-0.013892513,
-0.010727379,
0.022765372,
-0.01444297,
-0.014914792,
0.0054128375,
0.030432466,
-0.012300116,
0.01885974,
-0.021048468,
-0.0115071945,
0.007542586,
0.0014826325,
-0.0061041866,
-0.007896451,
-0.0001265562,
0.02783745,
-0.00333879,
0.009017027,
0.01478373,
-0.034678858,
0.010399725,
-0.019121863,
-0.00827653,
-0.0142070595,
-0.007857134,
0.020471796,
-0.00026232767,
0.01286368,
0.02035384,
-0.023119237,
-0.010314535,
-0.018086478,
-0.011526854,
0.012214926,
-0.0055668345,
-0.009292256,
-0.011428557,
-0.029986857,
0.026435092,
-0.024141517,
-0.00069093955,
-0.0026818446,
-0.01000654,
0.016972456,
-0.011002608,
0.003446916,
-0.005465262,
-0.02114021,
-0.0070707644,
0.0056978962,
-0.012516367,
0.01501964,
0.030668376,
0.012103524,
-0.011074691,
0.027706388,
0.016815182,
0.023433786,
0.042332843,
0.00003673304,
-0.028754879,
0.010976396,
0.021061573,
0.017116623,
-0.033892486,
0.03357794,
-0.013335501,
0.025294857,
0.0006057496,
0.024010455,
-0.0056028767,
-0.0065334127,
0.013617284,
0.03297506,
-0.0024098922,
0.0034010443,
-0.0059829545,
0.019357774,
0.017588444,
0.018335495,
-0.009593697,
-0.0192005,
-0.015150703,
-0.013918725,
-0.012516367,
-0.043931793,
-0.03116641,
0.014705094,
0.014626456,
0.01821754,
-0.007280463,
-0.0035583181,
-0.020786343,
0.0053571365,
-0.018374814,
-0.030694589,
-0.0101441555,
0.002151046,
-0.0058355103,
0.020445583,
-0.005478368,
-0.0024590401,
0.0015391528,
0.020262098,
0.019633003,
-0.039266005,
0.026749639,
0.022201808,
0.008296189,
0.0066710273,
-0.027785026,
-0.014049786,
0.02817821,
-0.030668376,
0.011277837,
0.004737871,
-0.018230647,
0.07690685,
0.0042463904,
0.0066906866,
-0.0056421948,
0.010170368,
0.029777158,
0.015596312,
0.005966572,
-0.025963271,
-0.019357774,
-0.0018119244,
0.0075491387,
0.017798143,
-0.004633022,
-0.003882695,
0.0005377615,
-0.0055373455,
0.009410211,
-0.005393178,
-0.023158556,
0.024652656,
-0.02062907,
0.015963282,
-0.02372212,
-0.015714267,
0.0014457715,
0.018283071,
0.007182167,
-0.016002601,
-0.0038171643,
-0.010556999,
0.018427238,
-0.022608098,
-0.016015708,
0.0144298645,
-0.030091707,
-0.004878762,
-0.007110083,
0.0053636893,
-0.00067824294,
-0.01352554,
0.02521622,
-0.025019629,
-0.034862343,
-0.026159864,
-0.0075753513,
-0.0014908238,
0.023800757,
-0.011749658
] |
We report on a patient treated with hemoperfusion-hemodialysis (HP-HD) for severe paraquat poisoning. This procedure was adopted since the combination of adsorption and dialysis may improve overall drug removal. On admission blood paraquat was 15.8 micrograms/ml. He received conventional treatment and combined HP-HD which started within 3 hours after ingestion of the chemical and lasted 5 hours. Blood samples were obtained during and after HP-HD. The samples during HP-HD were taken before the charcoal column, between the charcoal column and the artificial kidney and after the artificial kidney. Blood clearances of paraquat | [
0.009084562,
0.019798642,
0.023641588,
-0.03134106,
-0.023193471,
0.041118167,
-0.0030247925,
-0.022134284,
-0.036283933,
0.017354365,
-0.010551129,
0.03169412,
-0.0043351967,
0.016743297,
-0.018576503,
-0.0033693677,
0.033024896,
0.0016643149,
0.0018943145,
-0.011997325,
-0.008989507,
0.017422263,
-0.004627152,
0.015697688,
-0.025637748,
0.01906536,
0.023940334,
-0.013803374,
0.0058798436,
-0.0058085523,
-0.01724573,
-0.012459022,
-0.025678486,
-0.015493999,
-0.020654138,
0.015575475,
-0.004905528,
0.014366915,
0.011420204,
-0.0049632397,
0.028272135,
-0.017137095,
-0.00083215744,
-0.0023644983,
-0.017367944,
-0.015331048,
-0.020789932,
-0.035822235,
-0.013959536,
0.018169124,
0.025366161,
-0.01526315,
-0.007258144,
0.032047186,
0.011732529,
-0.0027735753,
0.0141768055,
0.031096634,
0.0058662645,
-0.024510665,
-0.009980797,
-0.0073871478,
-0.008704341,
0.012778136,
-0.022052808,
-0.0053943833,
-0.011270832,
0.006806632,
-0.009091352,
0.0056489953,
0.03631109,
0.04128112,
-0.011569577,
-0.016566765,
0.02638461,
-0.02046403,
-0.022935463,
0.010469653,
-0.01013017,
0.0014402561,
0.02878815,
-0.04003182,
-0.007943899,
0.020002332,
0.04052068,
-0.0060597695,
0.009566627,
0.032970577,
0.028027708,
0.0020029491,
0.012092381,
0.022908306,
0.0045185173,
0.008405596,
-0.0049564503,
0.016974144,
0.0066572595,
0.04606104,
-0.012248543,
-0.028136343,
-0.03511611,
-0.009668472,
-0.04106385,
-0.015303888,
-0.024510665,
0.01625444,
0.0011033193,
-0.0071087717,
0.010843083,
0.0048885536,
-0.0077945273,
0.030662095,
0.012031274,
-0.025026679,
-0.004447226,
0.010286331,
0.011223304,
-0.006134456,
-0.0086092865,
-0.031015156,
0.016756875,
0.01409533,
0.022908306,
-0.020749195,
0.015412523,
0.029249845,
-0.009491942,
-0.023886016,
0.030118922,
-0.009064193,
-0.007556889,
0.028706674,
0.021645429,
-0.01169858,
-0.037587546,
0.038157877,
-0.04418709,
-0.0277697,
-0.042611893,
-0.016933406,
-0.0062329057,
0.008812976,
0.025637748,
-0.01884809,
-0.018929565,
0.008711131,
0.028136343,
0.02938564,
-0.0035000686,
0.006501097,
0.008717921,
-0.0064332006,
0.0055743093,
-0.013803374,
-0.007624786,
-0.014312599,
-0.00795069,
0.01288677,
-0.013070092,
0.0065757837,
-0.031666964,
-0.013253412,
-0.008487072,
-0.0119362185,
0.019798642,
0.0092475135,
0.012961457,
0.0018569714,
0.017802482,
-0.024469927,
-0.011087511,
0.036338247,
-0.020884987,
-0.0032182978,
0.021020781,
0.010809136,
0.013178726,
0.010612235,
-0.018359235,
-0.034382828,
-0.01644455,
0.026832728,
0.012092381,
0.013640422,
-0.0056218365,
-0.012717029,
0.021251628,
-0.027267266,
0.0010710685,
-0.008887662,
0.0012357177,
0.016430972,
-0.037370276,
-0.025746383,
-0.6392055,
-0.022786092,
-0.010551129,
-0.009695631,
0.015752006,
0.01011659,
0.029114053,
-0.0065316507,
0.0025087786,
0.030146081,
0.019173993,
0.017028462,
-0.0022949043,
0.003423685,
-0.014380495,
-0.00774021,
-0.01548042,
-0.01071408,
0.022786092,
0.0023356422,
-0.006188773,
-0.011678211,
-0.030743571,
0.017585214,
0.010625814,
0.014271861,
0.009926479,
-0.012411495,
-0.0018569714,
0.016702559,
0.0008936887,
0.014353337,
0.016580345,
0.010415335,
0.04902133,
-0.020871408,
-0.009940059,
0.011997325,
0.011026404,
0.04228599,
-0.0031385194,
0.014136068,
0.027810438,
-0.00038722268,
-0.020341815,
-0.0017636137,
0.017530896,
-0.005594678,
-0.014041012,
-0.00084955595,
0.020939305,
0.010232015,
0.009301831,
0.012669502,
-0.00027604203,
0.0039923186,
0.0009845004,
-0.021957753,
0.0026394795,
-0.0074754134,
0.0032743125,
0.017585214,
0.005020952,
-0.02300336,
-0.027538853,
0.007665524,
-0.025040258,
-0.00084319065,
0.014597764,
-0.009009876,
0.014706398,
0.02399465,
0.0050073727,
0.009179617,
0.025827859,
-0.0062329057,
0.017123517,
0.004202798,
0.0048512104,
0.024048967,
-0.0025053837,
-0.0052687745,
-0.0024154207,
0.022663878,
0.027280845,
-0.0003496674,
-0.035849392,
0.02938564,
0.023926754,
-0.015819903,
0.017734585,
-0.012431864,
-0.0009429137,
-0.018576503,
-0.042367466,
0.034817364,
-0.014190385,
-0.0057813935,
-0.012268912,
0.00312494,
-0.017544476,
-0.033893973,
-0.0020352,
-0.008459914,
0.024076127,
0.0039413963,
-0.026914204,
-0.00022809007,
0.043698236,
-0.005733866,
-0.0009921388,
-0.010354228,
-0.0012713635,
-0.01565695,
0.017096357,
-0.023668747,
0.009043824,
0.003934607,
-0.009885741,
-0.024741514,
0.021754064,
-0.015127357,
0.036799945,
0.019676428,
-0.0042401413,
0.03155833,
0.0014512894,
-0.010401756,
-0.028679514,
-0.020097388,
0.0033167477,
0.008561758,
0.018712297,
-0.0074550444,
0.010836294,
-0.015208834,
0.018386394,
-0.0029059735,
0.013762636,
-0.01131157,
-0.015208834,
-0.0022626536,
-0.013171936,
0.004681469,
0.002670033,
-0.021523215,
-0.0068643442,
0.008799396,
-0.029521432,
0.0002881361,
0.005200878,
-0.002765088,
-0.01150847,
0.021455318,
-0.0065961527,
-0.014122488,
0.006056375,
-0.027661067,
-0.015358206,
-0.013266991,
0.019622112,
0.0054656747,
-0.0091253,
-0.0011092604,
-0.0049292916,
-0.04521912,
0.024266237,
0.016458131,
-0.010965297,
-0.013321308,
0.0024306974,
-0.03864673,
-0.00892161,
0.005811947,
-0.0070340857,
0.02933132,
0.012798505,
-0.011542418,
0.0077266307,
0.011155408,
0.00516014,
-0.012730609,
-0.013749057,
0.010388176,
0.014448392,
0.0010456073,
0.004603388,
0.033079214,
-0.0012509944,
0.025366161,
-0.00081093976,
-0.0037241273,
-0.037587546,
-0.010938139,
0.0046169674,
-0.016159385,
0.002142137,
-0.008453124,
0.01806049,
0.026031548,
0.04149839,
-0.0057033123,
0.015887799,
-0.0029738701,
0.02141458,
0.026438927,
-0.0039923186,
-0.0069186613,
0.042367466,
0.009037035,
-0.0046916534,
-0.0036630204,
-0.0043725395,
-0.022079967,
-0.03397545,
0.028923942,
-0.015724847,
-0.008887662,
-0.019825801,
0.009607365,
0.027280845,
-0.027620329,
0.01724573,
0.0030332797,
-0.015616213,
-0.013402784,
0.025135312,
0.025488375,
0.015018723,
0.0063041975,
-0.015643371,
0.0041960087,
0.0048376312,
0.007393937,
0.008072903,
0.022555243,
0.012594815,
-0.0011949798,
0.034844525,
-0.0009955335,
-0.027620329,
0.0043555656,
0.02260956,
-0.017951855,
-0.016770454,
-0.0044506206,
0.027647486,
0.004925897,
-0.015996434,
0.006843975,
-0.0038395515,
0.018413551,
0.009648103,
0.0039651603,
-0.0002771029,
-0.013715109,
0.006721761,
0.02518963,
0.016335916,
0.014258281,
0.009695631,
-0.00017727372,
0.0077469996,
-0.02637103,
-0.001484389,
-0.027145052,
0.019934434,
-0.011141828,
-0.011630684,
-0.009166038,
-0.013328098,
-0.019893697,
0.0037784446,
-0.019133255,
-0.011006035,
0.015602633,
0.0046746796,
-0.019133255,
0.023071257,
-0.0019639086,
-0.027498115,
-0.019540636,
0.021129414,
0.012655922,
-0.0039583705,
-0.0162816,
-0.0037648652,
-0.006589363,
0.010198066,
0.027498115,
0.006694603,
0.005716892,
0.022514505,
0.037967768,
0.0046441257,
-0.033812497,
0.033377957,
0.00040228723,
-0.0034423566,
-0.007319251,
-0.024904465,
-0.005811947,
-0.017313628,
-0.025529113,
0.03386681,
0.0016600713,
0.00873829,
-0.040955216,
0.016688978,
-0.0034576333,
0.0099740075,
0.00733962,
-0.00773342,
0.020586243,
-0.02998313,
0.017816061,
-0.028326452,
0.02916837,
0.041742817,
-0.018277759,
-0.0070137163,
-0.024116864,
0.0072106165,
0.010103011,
0.04008614,
0.014570606,
0.0016329127,
0.020097388,
-0.030309033,
-0.0031317296,
0.007020506,
-0.018413551,
0.024945203,
0.0050481106,
0.019432,
0.015344626,
0.0057270764,
0.011006035,
0.004664495,
0.0166754,
-0.008473493,
-0.021726904,
-0.010843083,
-0.010232015,
-0.0015251269,
-0.01308367,
0.025434058,
0.026031548,
-0.0054690694,
0.005411357,
0.012846032,
0.001826418,
0.046196833,
0.0065723886,
-0.016240861,
0.0022066387,
0.0186444,
0.009899321,
0.0058187367,
0.0050820587,
0.008616076,
-0.019418422,
0.02616734,
-0.00013462619,
0.002666638,
0.018590083,
0.009417255,
0.0035883342,
0.030118922,
-0.0013901824,
-0.005577704,
0.0030044236,
-0.020246759,
-0.019798642,
0.030390508,
-0.002031805,
-0.022378713,
-0.012201015,
-0.009580207,
0.00031168773,
0.009091352,
-0.008500651,
0.004403093,
0.018956725,
-0.0056659696,
-0.036555517,
0.024768671,
0.0072038267,
-0.024130443,
0.00366981,
-0.032264452,
-0.02339716,
0.0025817673,
0.026085865,
-0.020301078,
-0.019540636,
-0.014923668,
-0.0011372677,
0.009240724,
-0.0060054525,
0.013273781,
-0.018753035,
-0.0053875935,
0.000684058,
-0.021401001,
-0.009383307,
-0.006429806,
-0.013538578,
0.014787874,
0.023383582,
-0.0048512104,
0.014828613,
-0.028435087,
0.0055810986,
0.03112379,
-0.021265209,
0.008914821,
0.011094301,
-0.009817845,
-0.014815033,
0.009084562,
0.014991565,
0.0023441294,
-0.0067319456,
-0.006585968,
-0.018603662,
-0.011297991,
-0.012526918,
0.023302106,
-0.03253604,
0.0016532816,
0.00357136,
-0.009559838,
-0.015249572,
0.039434332,
-0.005676154,
-0.009763528,
-0.01288677,
0.03191139,
0.0017092964,
-0.004100953,
0.0003486065,
-0.002785457,
0.0037343118,
-0.009946848,
0.0066199163,
0.03927138,
-0.0017585214,
-0.011202935,
0.018386394,
0.015792744,
-0.0325632,
-0.046604212,
-0.0018009567,
-0.017598793,
0.03370386,
-0.0018824326,
0.0022473768,
-0.017367944,
-0.015792744,
-0.005479254,
0.010340649,
0.005132981,
-0.015982855,
-0.009858583,
0.0042129825,
0.008038955,
0.01368795,
0.0042537204,
-0.012744187,
-0.0072038267,
-0.0009038732,
-0.012757767,
-0.0049903984,
-0.008548179,
-0.028462246,
-0.0030129107,
0.00893519,
-0.030499144,
0.0044981483,
-0.00023551626,
0.009111721,
0.027728962,
0.028217819,
0.016688978,
-0.00416885,
0.011847952,
0.007577258,
0.0016074515,
0.009566627,
-0.019309787,
-0.006765894,
0.004508333,
0.012160277,
0.009009876,
-0.014801454,
-0.006585968,
-0.015439682,
0.013334888,
0.03316069,
-0.004953055,
0.008751869,
0.0008313087,
-0.02933132,
-0.010184486,
0.0023254578,
-0.0004510879,
0.0011321754,
-0.013755847,
-0.0025308449,
0.0128120845,
0.014054592,
-0.0014071566,
-0.0018654584,
0.011759687,
-0.008317331,
-0.017490158,
0.011162197,
0.005835711,
0.007359989,
-0.009199986,
-0.0026887045,
-0.011976956,
0.0064841234,
-0.0004133204,
-0.030471984,
0.008432755,
0.012330019,
-0.0029382245,
-0.00083003566,
-0.011325149,
-0.0325632,
-0.00093782146,
-0.03375818,
-0.015045881,
0.0080321655,
-0.0041926135,
-0.039407175,
-0.007319251,
-0.0027464165,
-0.007393937,
0.0042910636,
-0.0022541664,
-0.0147742955,
0.0101233795,
-0.0137286885,
0.03734312,
-0.006175194,
0.042340305,
0.03671847,
-0.018399972,
0.0027498114,
-0.0007965117,
0.0009157551,
0.0047968933,
0.013762636,
0.029249845,
-0.020206021,
-0.026411768,
0.009994376,
0.02759317,
-0.007896372,
-0.033839654,
0.023573691,
-0.0049836086,
-0.017164255,
-0.010883821,
-0.018630821,
-0.043372333,
0.022093546,
-0.021550374,
-0.010394966,
-0.006015637,
0.020952884,
-0.013715109,
0.00366981,
-0.028244976,
0.0004088647,
0.008812976,
-0.015249572,
-0.016213702,
-0.01408175,
-0.014543447,
0.009607365,
-0.018087648,
0.006725156,
-0.021455318,
-0.0023492216,
0.0016532816,
-0.0042706947,
-0.005536966,
-0.010191277,
-0.0051669297,
0.02992881,
0.0038870792,
0.018549345,
0.015385364,
0.025040258,
0.003968555,
-0.0150730405,
-0.022650298,
-0.027077155,
-0.005655785,
0.015426102,
0.018576503,
0.037180167,
-0.0069390303,
-0.010822714,
-0.031857073,
0.0010914375,
-0.010965297,
-0.0328891,
0.020246759,
-0.0420144,
-0.028299294,
-0.004919107,
-0.0025834648,
0.010829505,
-0.008120431,
0.0023458267,
-0.009342569,
0.019336944,
-0.0063720937,
0.00535704,
0.00030956595,
0.022568822,
-0.020599822,
0.004280879,
-0.020138126,
-0.030200398,
0.030091763,
-0.007068034,
-0.030499144,
-0.03427419,
-0.028407928,
0.0058628693,
0.022066388,
0.0014156436,
0.009267882,
0.0077945273,
0.015792744,
0.0062736436,
0.005754235,
0.031992868,
-0.02440203,
0.0076112063,
0.016363075,
-0.0061242715,
0.0016702558,
-0.019880118,
0.012520129,
-0.0073124613,
-0.020789932,
-0.028951101,
-0.03506179,
0.01605075,
-0.049673136,
-0.021971332,
-0.019907277,
-0.009491942,
-0.020328235,
0.0074346755,
-0.014801454,
-0.0031487038,
0.010327069,
0.00042414144,
-0.011949798,
0.0027633908,
0.002646269,
0.01091777,
-0.010157328,
-0.015385364,
-0.025121734,
0.00892161,
-0.017150676,
0.014964405,
0.022147864,
-0.023682326,
-0.03234593,
-0.007353199,
-0.038836844,
0.0009878952,
-0.024714354,
0.0016880786,
0.016240861,
0.0027498114,
0.008582127,
0.019432,
-0.00932899,
0.016688978,
-0.000053495078,
0.0011152013,
0.0035883342,
-0.0051227966,
0.02165901,
-0.0014453484,
-0.039651603,
-0.011494891,
0.0032250874,
-0.006589363,
0.013416364,
0.011216515,
0.018820932,
-0.029249845,
-0.00342029,
0.0015718058,
0.0052484055,
-0.014122488,
-0.024157602,
-0.0013401087,
0.000565239,
0.012479391,
-0.0035679652,
-0.013178726,
0.004280879,
0.050705165,
-0.005971504,
-0.014258281,
-0.032020025,
-0.028000548,
0.012425073,
-0.007862424,
0.0005805157,
0.007943899,
-0.01230286,
0.021142995,
0.010041904,
0.004528702,
-0.021984912,
0.00049734244,
-0.009736369,
-0.021577533,
0.008914821,
-0.015018723,
0.02876099,
-0.021496056,
0.006708182,
0.0038191825,
-0.014190385,
0.009478362,
-0.010666552,
0.002310181,
0.04388835,
0.016417392,
-0.011467732,
-0.0035408065,
0.013945957,
0.001507304,
0.01823702,
-0.009213566,
-0.005730471,
-0.0372888,
-0.012445442,
0.0028160105,
0.0055030175,
0.011481311,
0.011399835,
-0.01389164,
0.008385227,
0.028353611,
0.1762052,
-0.025162471,
0.025339004,
0.020654138,
-0.008392017,
-0.0025410294,
-0.009811056,
0.01926905,
-0.0005351099,
0.020219602,
0.022908306,
-0.004243536,
-0.029874494,
-0.004022872,
0.0027141657,
-0.0022456793,
-0.040574994,
-0.020749195,
-0.013375626,
-0.0036799945,
-0.018983884,
-0.012628764,
0.012676291,
-0.0043182224,
0.028244976,
-0.0054283314,
0.011481311,
0.0067726835,
0.023166312,
0.00466789,
0.005472464,
-0.006334751,
0.013755847,
-0.004046636,
0.027837597,
0.0031758624,
-0.008568548,
-0.006745525,
-0.018141966,
0.023193471,
0.0019214732,
0.019703588,
-0.015738428,
0.0016108463,
-0.014244702,
0.002223613,
0.013457102,
-0.009491942,
-0.0049360814,
0.013945957,
-0.030227557,
-0.008235855,
0.013769426,
-0.006721761,
-0.02026034,
-0.007991428,
0.013022563,
-0.010204855,
-0.0064807283,
0.04348097,
-0.0012560867,
0.015602633,
0.0062566698,
0.023940334,
-0.01986654,
0.02165901,
-0.017721007,
0.000543597,
0.0008185781,
0.005411357,
0.011365887,
-0.013613264,
-0.012262122,
0.0070951926,
-0.01763953,
-0.035143267,
-0.019907277,
0.039950345,
0.025515534,
0.008317331,
0.012594815,
-0.014149647,
-0.028353611,
0.014842192,
-0.043942664,
-0.019391263,
0.014801454,
0.009872163,
-0.029467115,
0.0190382,
0.025284685,
-0.009464783,
-0.015602633,
0.004521912,
0.0034372644,
0.0034321721,
0.0029551985,
0.010551129,
-0.016811192,
-0.029847335,
-0.009627734,
0.058119472,
-0.0046916534,
-0.0031639806,
-0.025013098,
0.020762773,
-0.02183554,
0.03967876,
0.011046773,
0.002067451,
0.0036154927,
-0.024850147,
0.009186407,
-0.0044777794,
0.0108702425,
0.041362595,
0.010394966,
-0.023845278,
0.008453124,
-0.015358206,
0.016566765,
-0.025664907,
0.0119158495,
0.009600576,
0.0030298848,
-0.023247788,
-0.018087648,
-0.0010659762,
0.0012221384,
-0.037478913,
-0.002649664,
0.006820211,
-0.00932899,
-0.02320705,
-0.012336808,
0.026696935,
-0.016621083,
-0.0055641243,
-0.0052280365,
0.016661821,
-0.0019197757,
-0.01704204,
0.020789932,
0.010021535,
0.035822235,
-0.028272135,
0.010191277,
-0.0098450035,
-0.02241945,
-0.0017704032,
-0.032617517,
0.0026751251,
-0.01747658,
-0.013654002,
0.017327206,
-0.02736232,
-0.024945203,
-0.01945916,
0.020341815,
0.0017008092,
-0.004046636,
0.0068745287,
0.010897401,
-0.03117811,
0.0020946094,
0.0018230231,
-0.172403,
0.006881318,
0.016770454,
-0.0005215306,
0.02001591,
-0.008677183,
0.023057679,
0.012119539,
-0.012723818,
-0.0062261163,
0.021183733,
-0.002174388,
-0.015792744,
-0.038728207,
0.014244702,
0.011481311,
-0.013124408,
0.025080996,
0.03454578,
0.010578287,
0.010469653,
0.00993327,
0.02479583,
-0.012941088,
0.023234209,
-0.012526918,
0.002359406,
0.018359235,
0.0015641674,
-0.0030655304,
-0.0075433096,
-0.0039142375,
0.012072012,
-0.008100062,
-0.0048512104,
-0.01466566,
0.009451204,
-0.0037580756,
-0.0062464853,
0.03533338,
0.015589055,
0.009566627,
0.0012968247,
0.0033880393,
-0.014407653,
0.026099445,
0.0034627256,
0.008086482,
0.00015934478,
0.0012068617,
0.031829916,
-0.025542693,
0.0070544546,
0.023668747,
0.005177114,
-0.0058798436,
-0.017381525,
0.0039651603,
-0.009858583,
0.009288251,
0.0016218795,
-0.0096752625,
0.008792607,
0.008826555,
-0.008792607,
-0.019296207,
-0.026941363,
-0.01289356,
0.0031504012,
0.0034185927,
-0.044132777,
-0.023899596,
0.005044716,
0.006334751,
0.017435841,
0.002301694,
-0.011630684,
-0.013049723,
0.014068171,
0.010089432,
-0.005472464,
0.03117811,
-0.020178864,
-0.0012340203,
-0.021781223,
0.01070729,
-0.001046456,
0.0046305466,
-0.022039229,
-0.01448913,
0.020138126,
-0.020178864,
0.0068948977,
-0.019106098,
0.020002332,
0.011264042,
0.007624786,
-0.00012826087,
0.021726904,
-0.029738702,
0.035849392,
-0.005716892,
-0.041552704,
-0.004294459,
0.008690762,
-0.0074550444,
0.008541389,
-0.008704341,
0.03158549,
-0.002846564,
0.004932686,
0.00042117096,
0.008745079,
0.012472602,
-0.004403093,
0.018006172,
-0.0077469996,
-0.0059443456,
-0.020151705,
-0.034247033,
0.04763624,
-0.0038599204,
-0.023057679,
0.018902408,
0.002899184,
0.0015947209,
-0.12471244,
0.005475859,
0.017028462,
0.02459214,
0.02262314,
-0.005333276,
0.013090461,
0.000035062218,
-0.001136419,
0.02897826,
-0.012343598,
-0.03036335,
-0.022867568,
0.009586996,
0.048858378,
0.025406899,
0.0110399835,
-0.022147864,
0.010333859,
0.033187848,
-0.018359235,
-0.014706398,
-0.007068034,
-0.018739456,
-0.0037411014,
-0.008812976,
-0.015439682,
0.03055346,
0.03231877,
0.04109101,
0.036012344,
0.0010515483,
-0.0035781497,
-0.009403676,
-0.015534737,
0.007848844,
-0.008154379,
0.016349496,
0.02026034,
-0.027090734,
0.0010074155,
0.008120431,
0.0056048627,
0.007638365,
0.05021631,
0.01031349,
-0.033079214,
0.00595453,
-0.011277622,
-0.024239078,
-0.039705917,
-0.0037750497,
-0.0010837992,
0.0025681881,
0.012608395,
-0.021984912,
0.0023729855,
0.01766669,
-0.04125396,
0.010951718,
-0.02163185,
0.0060427953,
-0.008385227,
-0.0056218365,
0.013749057,
-0.020273918,
-0.027946232,
-0.019540636,
0.015127357,
-0.01626802,
-0.012031274,
0.0017822852,
-0.005312907,
0.010843083,
-0.021903437,
-0.007638365,
0.0059816884,
-0.0030366743,
-0.0049496605,
-0.00017833461,
-0.008677183,
-0.008188327,
-0.0017687059,
-0.022297237,
0.0033761573,
-0.0017194808,
0.037017215,
0.0032369692,
0.0038938688,
-0.015955696,
-0.02992881,
0.041471228,
-0.0101233795,
-0.022147864,
0.010401756,
0.017558055,
0.0012357177,
-0.017544476,
0.030797888,
0.028054865,
-0.014964405,
-0.015331048,
-0.055050544,
-0.0065044924,
-0.002264351,
0.0065588094,
0.0022337975,
-0.0050515053,
0.005516597,
0.028244976,
0.0059273713,
-0.016702559,
-0.02437487,
0.0036188876,
-0.044105615,
0.0026836123,
-0.038999796,
-0.0095191,
0.033242166,
-0.006103902,
0.0126830805,
0.020219602,
-0.018196283,
0.0037818393,
0.011202935,
0.024361292,
-0.008256224,
-0.0044981483,
-0.017395103,
0.009349359,
-0.010666552,
-0.004141691,
0.0040704,
-0.007244565,
0.007278513,
-0.016607502,
0.017490158,
-0.01983938,
-0.025013098,
0.012866401,
-0.017286468,
0.022351554,
-0.024850147,
-0.019146835,
0.0013222859,
-0.020002332,
-0.006127666,
0.03234593,
0.0045762295,
0.03609382,
-0.0077673686,
-0.016946986,
0.035224743,
0.0077741584,
0.002936527,
-0.027891913,
-0.023573691,
0.0047561554,
-0.028896784,
-0.004953055,
0.007692682,
-0.027240107,
0.017123517,
-0.0122349635,
0.012126328,
-0.016159385,
0.01290035,
-0.018603662,
-0.0028906967,
-0.021142995,
0.018033331,
-0.020382553,
-0.013633633,
-0.01846787,
0.002965383,
0.00416206,
0.010924559,
-0.001136419,
-0.010075852,
0.02183554,
0.0028312872,
0.0039923186,
0.0031622832,
0.0026343872,
-0.027538853,
0.009390097,
0.017585214,
0.019581374,
-0.027145052,
0.023953913,
-0.0071495096,
0.029304164,
-0.017721007,
0.006585968,
0.0024748303,
0.0011296293,
-0.004348776,
0.01844071,
0.017856799,
-0.016213702,
-0.0022253103,
0.019499898,
0.000026416012,
-0.0053298813,
-0.016661821,
-0.02399465,
-0.025094574,
-0.013599684,
-0.01229607,
-0.023573691,
-0.024469927,
0.019676428,
0.0026055311,
0.0084802825,
0.021876277,
0.016593924,
-0.012336808,
0.010265962,
-0.009566627,
-0.010164117,
-0.011175777,
0.05336671,
0.008772238,
-0.0015514368,
0.015969275,
0.0043555656,
0.055729512,
0.0016430971,
0.018114807,
-0.013008985,
0.03351375,
0.0002900457,
0.008419176,
-0.01945916,
-0.045925245,
-0.0186444,
0.014570606,
-0.012262122,
0.012425073,
0.027715383,
0.032074343,
0.07973774,
0.014584185,
-0.021536794,
0.009817845,
-0.0040771896,
0.01924189,
0.0001482055,
-0.0027056786,
0.0004328407,
-0.040792264,
0.013830533,
-0.003982134,
0.025298266,
-0.046740003,
-0.024863727,
-0.016403813,
0.00322339,
0.008500651,
-0.012459022,
0.0072309854,
0.028000548,
0.0042673,
0.0014063079,
0.016743297,
-0.02520321,
0.0063381456,
0.027158631,
-0.008276593,
0.0060529797,
-0.035034634,
0.008079693,
0.020722035,
-0.0313139,
-0.030254714,
0.02046403,
0.011236884,
-0.036446884,
-0.014326178,
0.008941979,
0.01664824,
-0.00048546054,
0.055783827,
-0.025366161,
0.007577258,
-0.027090734,
-0.02897826,
-0.020504767,
-0.031232426,
-0.00036918765
] |
The number of cancer survivors continues to increase due to the aging and growth of the population and improvements in early detection and treatment. In order for the public health community to better serve these survivors, the American Cancer Society and the National Cancer Institute collaborated to estimate the number of current and future cancer survivors using data from the Surveillance, Epidemiology, and End Results (SEER) program registries. In addition, current treatment patterns for the most common cancer types are described based on information in the National Cancer Data Base and the SEER and SEER-Medicare linked databases; treatment-related side effects are also briefly described. Nearly 14.5 | [
0.007780585,
-0.014526378,
0.0128825,
-0.04705027,
-0.0011125647,
-0.00048669588,
-0.013805954,
0.0071453014,
-0.020551747,
0.016111312,
-0.015273,
0.033322908,
-0.0012656549,
0.007813332,
-0.011107637,
0.0143168,
0.033060938,
-0.012522289,
0.0016193178,
-0.009804323,
0.0018436318,
-0.0048628654,
-0.013301657,
0.006136707,
-0.002816205,
0.009254181,
0.0219664,
-0.034632772,
0.03455418,
-0.016635258,
0.000007834872,
0.0029946738,
-0.018403571,
-0.015613564,
-0.01967414,
0.025751902,
0.009876366,
-0.002347929,
0.027716696,
-0.01651737,
0.02080062,
-0.013386797,
0.001236183,
-0.003949236,
-0.008651644,
-0.000035304896,
-0.001106834,
-0.033768263,
-0.010603339,
0.018338079,
0.00653949,
-0.010413409,
-0.013714263,
-0.014644266,
-0.0076888944,
-0.022346258,
-0.027559513,
0.033270516,
0.0068571316,
-0.010072845,
0.0022955346,
-0.0008370842,
-0.027533315,
0.017499767,
-0.014146518,
-0.0031927906,
-0.005891108,
0.0024281582,
0.00291117,
0.026171058,
0.034763757,
0.028869376,
0.003289393,
0.0042603286,
0.009503054,
-0.028004866,
-0.009909112,
0.017198497,
-0.003972159,
0.00505607,
0.015273,
-0.022634428,
-0.0059729745,
-0.0053016697,
0.004001631,
0.018311882,
-0.0018829277,
0.019006109,
-0.0060057207,
0.00035591426,
0.018193994,
0.015849339,
-0.014932436,
0.009293476,
0.014631167,
0.016072016,
0.017133005,
0.008166994,
-0.014421589,
-0.04154885,
-0.014107222,
0.018167797,
0.0021056044,
-0.010518198,
-0.008998757,
0.008049107,
0.0022218546,
0.0038902925,
0.028371628,
0.0048235697,
-0.003264833,
0.035261504,
-0.0038018767,
0.0021318016,
0.038588557,
-0.01823329,
0.026210355,
0.015403986,
0.0005026598,
-0.005576741,
0.033846855,
-0.014133419,
0.037750244,
-0.018678643,
0.016464975,
0.02606627,
-0.03790743,
-0.0057142763,
0.0038509965,
-0.0041948357,
0.009057701,
-0.012993839,
0.02996966,
0.0151682105,
-0.016491173,
0.017015118,
-0.004211209,
-0.0050069503,
-0.020119492,
-0.030546,
0.000006958646,
0.015901733,
0.007983614,
-0.01545638,
-0.006434701,
0.024284856,
0.023459643,
0.0054261065,
-0.008350375,
-0.0028685995,
0.013819052,
-0.004505928,
0.0067719906,
0.008081853,
-0.004076948,
-0.0044895546,
0.021206679,
0.02585669,
-0.014578773,
-0.020276675,
-0.009863267,
-0.0068505825,
-0.007361429,
-0.014133419,
-0.015600465,
0.021062594,
0.0002936958,
-0.0006103142,
-0.0129807405,
0.0031485825,
-0.01021693,
0.042098988,
0.0018583678,
0.010701579,
-0.022031892,
0.0022578759,
-0.026210355,
0.028502613,
-0.01926808,
-0.0070798085,
-0.010714677,
0.015443282,
0.02834543,
0.0037560314,
-0.021206679,
-0.004672935,
0.039793633,
0.0050724437,
-0.010662283,
-0.013897644,
-0.0012329083,
0.012109681,
0.015220606,
-0.014172715,
-0.6509494,
-0.014120321,
-0.0015333581,
-0.0011305753,
0.013805954,
0.011854258,
0.011736371,
-0.0033123156,
-0.021638934,
-0.0010568955,
0.008690939,
0.0032140757,
0.020879213,
-0.019451462,
-0.023629924,
-0.013832151,
-0.021822315,
-0.0012754789,
0.0023250065,
-0.0015636487,
-0.015980326,
0.014460885,
-0.019163292,
0.01566596,
0.00095783715,
0.02433725,
-0.0023724888,
-0.04505928,
0.022346258,
0.0016504271,
-0.01861315,
0.011035594,
0.007184597,
0.006863681,
0.036047425,
0.018390473,
0.0112386225,
0.012954542,
0.015024126,
0.022464147,
-0.0022496893,
0.009653688,
0.03062459,
0.01049855,
-0.034213617,
0.0046336395,
0.0061432566,
0.0017797761,
0.03877194,
-0.009751928,
0.018442867,
0.0023119077,
-0.009666787,
-0.020014703,
0.037881233,
0.017683148,
0.01956935,
-0.018364277,
0.0027523492,
0.0011739645,
0.019359771,
0.0105051,
-0.009155941,
-0.014382293,
-0.0019762556,
0.037069116,
-0.026328241,
0.021914003,
0.013989334,
-0.0033352382,
0.01679244,
0.031567693,
0.010361015,
-0.005327867,
0.034292206,
0.014395392,
0.006231672,
0.006546039,
-0.02348584,
0.006578786,
0.008127699,
-0.01823329,
-0.018089205,
0.013144473,
-0.004895612,
-0.03379446,
0.00008488525,
-0.0067261453,
0.018639347,
0.023263162,
0.0071911467,
-0.007033963,
-0.0017224696,
-0.020394564,
0.015286098,
0.0037560314,
0.0033483368,
-0.008618897,
0.0064903703,
-0.034213617,
-0.023603728,
-0.017434273,
0.008186642,
0.010472353,
0.033165727,
0.025503028,
-0.014198912,
0.001889477,
0.028031064,
-0.022660626,
0.017722443,
0.0070405123,
-0.013779757,
-0.008533756,
0.02157344,
-0.012921796,
0.0031518573,
0.028764587,
-0.013006938,
-0.023433445,
0.02711416,
0.029864872,
0.020787522,
-0.023983587,
0.035235308,
0.0010306983,
0.0051968805,
0.008042557,
0.014251307,
-0.028083459,
0.018770333,
-0.03740968,
0.0010437969,
-0.0065067434,
0.020473154,
-0.017997514,
-0.0028735115,
-0.007891923,
0.010262775,
-0.0043945895,
-0.004142441,
0.015849339,
0.018482164,
0.020853015,
-0.004306174,
-0.004715506,
0.008317629,
0.0013884546,
0.0019942662,
-0.017002018,
-0.0030716283,
-0.0101383375,
-0.0020417485,
0.011009397,
0.00830453,
0.00058084226,
-0.0004191561,
-0.032877557,
-0.014526378,
-0.015011027,
0.0012861216,
0.0029897618,
-0.012063836,
-0.019399067,
0.0056913537,
-0.005183782,
-0.015587367,
0.037462074,
-0.007276288,
-0.03217023,
-0.008370023,
-0.010531297,
0.0009791225,
0.012744965,
0.020250479,
0.008474812,
-0.013779757,
-0.023132177,
0.01355708,
-0.013144473,
-0.0055963886,
-0.015220606,
-0.0051968805,
0.0073745274,
0.019634843,
0.02539824,
0.025450634,
-0.022202173,
-0.00443716,
0.0025738804,
-0.032851357,
0.020119492,
-0.021403158,
0.032117836,
0.020211183,
-0.026406834,
-0.010341367,
-0.022634428,
0.018717939,
0.011828061,
0.027218949,
0.01660906,
0.027323738,
0.014683561,
-0.0029521033,
-0.003589024,
-0.0050527956,
0.008533756,
0.024127671,
-0.010727776,
0.013118275,
-0.016661454,
-0.0035759255,
0.014552576,
-0.000051652598,
0.019739632,
0.01994921,
-0.00023741263,
0.0074334713,
0.0015137101,
-0.037016723,
-0.003369622,
0.015770748,
-0.024376547,
0.0053245923,
0.021219777,
0.015967228,
0.007839529,
-0.007263189,
0.007983614,
-0.01260088,
0.016058918,
0.024232462,
0.027323738,
0.007806782,
0.016307792,
0.037540667,
-0.02520176,
0.022215273,
0.009470308,
-0.015574268,
0.0063823066,
-0.0033859953,
-0.0045845197,
-0.00734833,
-0.008324178,
0.0062578693,
0.009588196,
-0.021979498,
-0.01174292,
-0.0018829277,
0.017814133,
-0.017002018,
0.035916436,
-0.02262133,
-0.01785343,
0.017237794,
0.016713848,
0.033768263,
0.028476417,
0.034763757,
-0.0062611443,
0.021992596,
0.007151851,
-0.009876366,
-0.00036819425,
-0.01164468,
0.002467454,
0.010891509,
-0.018115401,
-0.014002433,
-0.016844835,
0.01489314,
-0.013570178,
-0.0038051514,
0.009745379,
-0.022372456,
-0.011795314,
0.0005603757,
0.0038542713,
-0.009129743,
-0.020970903,
0.020355267,
0.018193994,
-0.0036512425,
-0.016582863,
0.016674554,
-0.0023266438,
-0.023656122,
-0.010262775,
0.014434688,
0.022503443,
-0.025005281,
0.008324178,
0.0055374447,
0.025542324,
0.0060843127,
-0.0063986797,
0.0031223854,
0.022765415,
0.00687023,
-0.021259073,
-0.008821926,
-0.02585669,
0.019582449,
-0.011690525,
-0.010478903,
-0.019202588,
-0.05210634,
-0.037095312,
-0.013105177,
-0.019687237,
0.0012853028,
0.003235361,
0.011120735,
-0.0037200104,
0.009745379,
-0.01031517,
0.018272586,
-0.010059746,
0.0032762943,
-0.043251667,
0.0000887739,
0.0006860406,
0.07267119,
0.011317214,
-0.009666787,
0.012993839,
0.029550504,
-0.005193606,
-0.008848123,
-0.01127137,
-0.002421609,
0.017683148,
-0.018089205,
0.015639761,
0.028607404,
0.00095128786,
0.012672923,
0.031017551,
0.005832164,
-0.037645455,
-0.025804296,
-0.02424556,
-0.0139238415,
-0.0019467835,
0.056166917,
0.055380996,
0.027087962,
-0.018796531,
0.02233316,
0.03206544,
-0.002387225,
-0.004656562,
-0.011598835,
0.021036396,
-0.009856718,
0.04068434,
0.0022807985,
0.006375757,
0.022568936,
0.013517784,
0.022398654,
-0.009522703,
0.0068374835,
-0.018272586,
0.0142251095,
-0.0025476832,
0.011841159,
-0.024009785,
0.008559953,
0.014958633,
0.012541936,
-0.0012689296,
0.01708061,
-0.0044633574,
-0.029655293,
-0.01374046,
-0.010714677,
0.012947993,
0.0025902537,
-0.01469666,
-0.038117006,
-0.01956935,
-0.013301657,
0.00023761729,
0.0029193566,
0.0071714986,
-0.021652032,
-0.0066803,
-0.00022042534,
-0.011854258,
-0.017866528,
-0.006087587,
0.023813305,
-0.033165727,
-0.0035366295,
0.015508776,
0.0073417807,
-0.017381879,
0.018652447,
-0.016595962,
-0.00897256,
0.010819467,
0.0024609047,
0.008952912,
-0.02424556,
-0.036021225,
0.00772819,
0.02748092,
-0.016766243,
-0.027533315,
-0.032615583,
0.03837898,
-0.007891923,
-0.023643022,
0.011349961,
-0.019870618,
0.0019680688,
0.008926715,
0.026695004,
-0.00063037145,
-0.010727776,
-0.014185814,
0.0022971719,
-0.006071214,
-0.017814133,
-0.008474812,
-0.0059107556,
-0.017643852,
-0.0073090345,
0.00067376066,
-0.016150609,
-0.018940616,
0.026302045,
-0.023787107,
0.028397825,
-0.0181416,
-0.0011297567,
0.012063836,
0.010596789,
0.0077936836,
0.0043651178,
-0.0035169816,
0.010367564,
0.0071584,
0.025725706,
-0.009745379,
-0.016543567,
-0.011625032,
-0.010164535,
0.017761739,
-0.039295882,
-0.0104527045,
0.00772819,
0.029629096,
-0.024677815,
-0.04123448,
-0.016595962,
-0.02528035,
0.0066442788,
0.014356096,
0.011998343,
-0.014814548,
-0.024756407,
-0.006948822,
-0.010243127,
-0.015403986,
0.02634134,
-0.028293036,
0.0036610665,
0.010157986,
0.015299197,
0.0032762943,
-0.0027179653,
0.012358556,
0.01842977,
0.013845249,
0.005737199,
-0.01993611,
0.0090708,
0.018102303,
0.044902097,
0.020551747,
0.009208336,
-0.00094064523,
0.003598848,
0.0035104323,
0.0036970878,
0.0066933986,
-0.041758426,
0.019110898,
0.0029815752,
0.022490343,
-0.019123996,
0.019163292,
-0.012941444,
0.015233704,
0.042701527,
-0.010891509,
0.0109373545,
-0.03138431,
-0.032563187,
-0.038169403,
-0.03484235,
0.0017617655,
-0.009038053,
0.027218949,
-0.011566089,
-0.0022644252,
0.005039697,
0.0015710166,
-0.0056062127,
-0.003484235,
0.029995857,
0.012070386,
0.0019615195,
-0.023184571,
-0.011448201,
-0.028895574,
-0.02348584,
-0.032956146,
-0.017604556,
-0.010721227,
0.011415454,
0.023119077,
0.015692156,
-0.010184183,
0.018665545,
0.0023250065,
-0.044063784,
-0.0448497,
-0.0032042519,
-0.015403986,
0.009437561,
0.0062087495,
-0.012234119,
-0.012391302,
-0.0067981877,
-0.0058780094,
-0.0132885575,
0.021717524,
-0.010884959,
-0.016622158,
-0.0029668391,
-0.015927931,
0.0056848046,
-0.015508776,
0.03426601,
0.007872275,
-0.024717111,
-0.017539063,
-0.006683575,
0.012286513,
0.008808827,
0.046342947,
0.015548071,
-0.009155941,
-0.009155941,
0.024297955,
0.02548993,
-0.010053197,
-0.06156355,
0.0040703984,
-0.00071346585,
0.00060744886,
-0.021783018,
-0.023878798,
-0.01994921,
0.036047425,
-0.0003213257,
-0.0017519415,
0.008049107,
-0.015587367,
-0.0045223013,
0.019320477,
-0.023315558,
0.015757648,
0.010446155,
-0.012574683,
-0.022280766,
-0.026223453,
0.0029766632,
-0.0058550867,
-0.011821511,
0.018089205,
-0.006424877,
-0.013137924,
0.012928345,
-0.022608232,
-0.012194823,
0.011186228,
-0.023302458,
0.035575874,
-0.009620942,
-0.004705682,
-0.011323764,
-0.0059696995,
-0.012148977,
0.0148538435,
-0.020538649,
-0.00973883,
-0.019294279,
0.0020548473,
0.012627077,
0.016255397,
-0.014631167,
-0.00077322836,
-0.017381879,
-0.007381077,
-0.020735128,
-0.003349974,
0.0105051,
-0.016098214,
-0.010341367,
0.0035431788,
0.003847722,
0.03465897,
0.006385581,
-0.0023348304,
-0.0047973725,
0.030048251,
-0.028738389,
-0.010177634,
-0.0011641405,
0.005200155,
-0.008232487,
0.01393694,
-0.034868546,
-0.031829666,
-0.00021551336,
-0.009712633,
-0.027271343,
-0.022372456,
0.0030749028,
0.0043552937,
0.008219389,
0.0008260322,
-0.0049512815,
0.017434273,
0.016884131,
-0.023145275,
-0.018586952,
0.04055335,
-0.011559539,
0.0069750194,
0.012823557,
-0.018652447,
0.017434273,
-0.036964327,
0.00830453,
0.0066770255,
-0.0001784688,
-0.012744965,
-0.02042076,
0.0062283976,
-0.021874709,
0.017866528,
-0.005756847,
-0.0099877035,
-0.017198497,
0.026708102,
0.020250479,
0.0075841052,
0.0010609889,
-0.019634843,
0.013688066,
0.006493645,
-0.010655734,
-0.010328268,
-0.029157545,
-0.012758063,
-0.017722443,
-0.001136306,
-0.012875951,
0.018482164,
0.026564017,
-0.001136306,
-0.030467408,
-0.017774837,
-0.044168573,
-0.0017028216,
0.011218974,
0.04288491,
0.013884545,
0.040029407,
-0.015312295,
0.015888635,
-0.0072697382,
0.00014725723,
-0.039269686,
-0.027428526,
0.019346673,
-0.009791224,
0.015692156,
-0.0016234112,
-0.03277277,
-0.019307377,
0.029131347,
-0.005144486,
-0.0030388816,
0.00601227,
-0.030493606,
-0.012568133,
0.017106809,
-0.0081015015,
-0.027507119,
-0.0071060057,
0.000559557,
-0.034685165,
0.008933264,
0.0076037534,
0.0011960685,
-0.0038542713,
-0.0037920526,
0.014421589,
0.016085114,
-0.009129743,
0.014342997,
-0.02070893,
-0.014081025,
-0.006077763,
0.0027310639,
0.02072203,
-0.0020024527,
0.031253327,
0.0120310895,
-0.005547269,
0.009863267,
0.0018878398,
-0.02501838,
-0.013504685,
0.000576749,
-0.002528035,
-0.008717136,
-0.010557494,
-0.022267668,
-0.0056913537,
-0.012286513,
0.0006180915,
-0.03675475,
-0.02404908,
0.029707687,
-0.004820295,
-0.03177727,
0.0002900118,
0.023538234,
-0.04610717,
-0.015495677,
-0.012299611,
0.017617654,
-0.025751902,
-0.007806782,
-0.012109681,
-0.004672935,
0.0066115325,
0.0068047373,
0.00033667567,
-0.009476857,
0.022175977,
0.20664395,
-0.020866115,
-0.014081025,
0.034213617,
0.0043552937,
0.005802692,
0.025516126,
-0.0042046597,
0.0061039603,
0.013111726,
-0.016543567,
-0.0071584,
-0.017054413,
0.0018993011,
0.025647113,
-0.0045092027,
-0.04505928,
-0.0007859177,
-0.013871447,
0.028397825,
0.013478488,
0.018180896,
-0.017643852,
-0.009863267,
0.0145394765,
0.0021907454,
-0.009850168,
0.009561998,
0.015390888,
-0.012587781,
-0.013727362,
-0.011160031,
-0.011572638,
0.01326891,
-0.024900492,
-0.017355682,
0.023760911,
-0.029838674,
-0.0006516567,
-0.0025837044,
-0.003569376,
0.0021105164,
-0.0181416,
-0.006136707,
0.0038280739,
0.02014569,
0.008631996,
0.00032091638,
-0.010171085,
-0.020577945,
-0.049015064,
-0.023787107,
0.008062205,
0.015783846,
0.00338927,
0.009909112,
0.0505869,
-0.0036610665,
0.0012984015,
0.015796944,
0.0017077336,
-0.0029897618,
-0.041470256,
0.029052757,
-0.020171886,
0.020538649,
-0.008291432,
0.017316386,
0.021835413,
-0.016569763,
-0.008946363,
0.0006422421,
-0.017250894,
0.010393761,
-0.012869402,
0.0024838273,
0.022503443,
0.017617654,
0.001794512,
0.0030126844,
-0.0022267667,
0.005403184,
-0.02473021,
0.010642635,
-0.0059107556,
-0.021717524,
-0.00027384318,
0.006444525,
0.012705669,
0.00078837364,
-0.001704459,
0.008108051,
-0.017814133,
-0.019896816,
0.025843592,
0.01583624,
0.010203831,
0.00563241,
-0.012070386,
-0.014578773,
-0.021927103,
0.069579914,
-0.0051805074,
-0.0061399816,
0.013478488,
-0.005020049,
-0.012764613,
0.019215686,
0.01011214,
-0.0091952365,
0.010439606,
-0.011808413,
0.02166513,
-0.019818224,
0.003932863,
0.017329484,
-0.021783018,
-0.023053585,
0.0043356456,
-0.014591872,
-0.007983614,
-0.047181256,
-0.01594103,
0.04026518,
-0.015089619,
-0.0047580767,
-0.022477245,
-0.031096142,
-0.021259073,
-0.036833342,
-0.028528811,
-0.015888635,
-0.004780999,
-0.0050069503,
-0.004384766,
-0.015679058,
-0.0050102253,
0.0069553712,
-0.020853015,
0.008337277,
-0.0036283198,
-0.028738389,
-0.00429635,
0.020564845,
-0.008854672,
-0.0115529895,
0.010564043,
0.029026559,
-0.023236966,
0.0036807144,
-0.006785089,
-0.002338105,
0.006519842,
0.020918509,
0.025804296,
-0.036335595,
-0.028581206,
-0.026878385,
0.0074334713,
0.016491173,
-0.025031477,
0.0017666774,
0.041077297,
-0.013478488,
-0.0010487089,
0.0061923764,
-0.1651475,
0.0070863576,
0.01079327,
-0.027716696,
-0.0020613966,
-0.017211597,
0.0024609047,
0.015862439,
-0.008337277,
0.0038117007,
0.02816205,
0.006189102,
-0.041365467,
-0.013622573,
0.0065722363,
-0.0019713435,
-0.016674554,
0.049303234,
0.039505463,
0.01594103,
0.025319647,
0.0041064196,
0.00062382215,
-0.021874709,
-0.0036348691,
0.005923854,
0.0068374835,
0.0019336849,
0.00076626975,
-0.0021760096,
-0.02158654,
0.005891108,
0.024232462,
-0.032379806,
-0.024468238,
0.0038444472,
-0.0131313745,
0.0009177226,
-0.0061923764,
0.007898472,
0.020106394,
0.0073548793,
0.012443696,
0.03133192,
-0.006785089,
0.010865312,
0.026956975,
-0.0050004013,
0.021494849,
-0.0036053972,
0.007675796,
-0.02129837,
-0.004715506,
-0.016530469,
-0.010996298,
0.0139107425,
0.016281594,
-0.017237794,
0.023747813,
0.012823557,
-0.0039197644,
-0.035182916,
0.0073155835,
0.0041096946,
-0.013714263,
-0.020656535,
-0.02070893,
0.00878263,
-0.03036262,
0.0025198485,
-0.02213668,
0.007878824,
0.007466218,
-0.022490343,
0.03465897,
-0.0043454696,
-0.011225524,
-0.0047613513,
-0.0067261453,
-0.012587781,
0.010537846,
0.0002900118,
0.0049480065,
-0.01594103,
-0.016857933,
0.004561597,
0.018717939,
0.014264406,
0.014683561,
-0.01556117,
0.03282516,
-0.034920942,
0.009791224,
-0.019399067,
0.014919337,
0.02664261,
0.0024510808,
-0.0020843192,
0.008664742,
-0.017591458,
0.013393347,
-0.004273427,
-0.00496438,
0.008789179,
0.009182138,
-0.010099042,
-0.02653782,
-0.0023692143,
0.0059729745,
0.0045190267,
-0.008605799,
0.018259486,
0.023643022,
-0.00534424,
0.010917706,
0.020774424,
-0.02137696,
0.0022071188,
-0.025424436,
-0.014722858,
0.04754802,
-0.0022300414,
0.003269745,
-0.005278747,
0.024834998,
-0.013092078,
-0.10950453,
0.006185827,
0.0026082643,
0.031410508,
0.015508776,
0.02175682,
-0.006758892,
0.008638545,
-0.035471085,
0.03473756,
0.0014121959,
-0.028764587,
-0.022961894,
0.011690525,
0.044168573,
-0.00058166095,
-0.0019975407,
-0.046814494,
-0.013832151,
0.025463732,
0.029026559,
-0.0047580767,
-0.0013196868,
-0.02547683,
-0.0026524721,
-0.009038053,
-0.005557093,
0.008088402,
0.004358568,
0.0151682105,
-0.0020646711,
-0.0037069116,
-0.015207507,
-0.0043945895,
-0.0099877035,
0.007243541,
-0.038614754,
-0.013530882,
0.011998343,
-0.048543513,
0.010079394,
0.0002883745,
0.007014315,
-0.0039557857,
-0.014356096,
-0.028685994,
-0.033951644,
0.021521045,
0.022988092,
-0.025751902,
-0.007197696,
-0.031646285,
0.0002701592,
-0.0001923861,
-0.004181737,
-0.0036577918,
0.0034056432,
-0.004142441,
-0.005524346,
-0.0026999547,
-0.0012902148,
0.016176805,
-0.024324153,
0.014788351,
-0.00334015,
-0.0025689683,
-0.009103546,
0.010963552,
0.008743334,
-0.0162423,
-0.003299217,
-0.008009811,
-0.028319234,
0.010426507,
-0.017683148,
0.007695444,
-0.0051805074,
0.0027212398,
0.022555837,
-0.020460056,
0.011395806,
-0.0008612348,
-0.0085665025,
0.00582234,
0.029602898,
0.013426093,
0.017447373,
-0.01785343,
0.004083497,
-0.00010918934,
0.027166555,
0.013688066,
-0.014277504,
-0.012705669,
0.009300026,
0.017041314,
0.0045419494,
-0.01040686,
0.005498149,
0.02424556,
-0.03282516,
0.00830453,
-0.056848045,
0.013871447,
0.010007352,
-0.012214471,
0.0020744952,
-0.006176003,
0.031934455,
-0.022372456,
0.006765441,
0.025935283,
-0.012640175,
0.021363862,
-0.019202588,
0.0095161535,
-0.013314755,
-0.01030862,
-0.001233727,
0.011972146,
0.01460497,
0.016294694,
-0.0012476443,
0.0129741905,
0.042151384,
0.0019664315,
-0.006231672,
0.019451462,
0.010164535,
0.020302873,
-0.02585669,
-0.008317629,
0.001241095,
0.0039885323,
-0.0028931594,
0.013963137,
-0.005242726,
-0.032510795,
0.019582449,
0.016111312,
0.02653782,
0.0037756795,
-0.017002018,
-0.023263162,
0.004646738,
0.007905022,
-0.026040072,
-0.007911571,
0.0044437093,
0.014015532,
-0.004266878,
0.017591458,
0.019307377,
0.00048710522,
0.0065067434,
-0.010492001,
-0.0011625033,
-0.010492001,
0.0080949515,
0.00083913084,
-0.0053311414,
-0.043539837,
0.023223868,
0.0128170075,
0.015194409,
0.010721227,
0.0045976182,
-0.0060843127,
-0.019752732,
0.0043028994,
-0.017329484,
-0.0016242298,
0.0035792,
0.008841574,
-0.0017814133,
0.01993611,
0.0015636487,
-0.017997514,
-0.017067512,
0.007014315,
0.00027343386,
0.0098305205,
0.016595962,
0.009018405,
0.0016299605,
0.01556117,
0.015679058,
0.016163707,
-0.018416671,
0.006274243,
0.008887419,
-0.016137509,
-0.011422004,
0.022726119,
0.01402863,
-0.002487102,
0.011572638,
0.013242712,
-0.0005751116,
0.017696247,
0.0013057694,
0.033846855,
-0.009876366,
-0.001799424,
-0.013111726,
-0.0023299183,
-0.017971316,
0.0050429716,
-0.014002433,
-0.015325394,
-0.027323738,
0.018063007,
0.01402863,
0.022477245,
-0.00496438,
0.00076012977,
-0.018403571,
0.010675382,
-0.013327854,
-0.007092907,
-0.0085665025,
0.022516541,
0.004086772,
0.011140383,
-0.0046925833,
-0.007852627,
0.023053585,
0.011775666,
0.007957417,
-0.016740046,
0.014945534,
0.0032140757,
-0.0028653247,
-0.023459643,
-0.016504271,
-0.009496505,
-0.012568133,
-0.02473021,
0.020695832,
0.016098214,
-0.0023299183,
0.04686689,
0.006493645,
-0.012993839,
0.01556117,
-0.021547243,
0.020119492,
0.010361015,
0.020067098,
-0.02034217,
-0.0106164375,
0.01994921,
-0.023236966,
0.010989749,
-0.019372871,
0.01955625,
0.0118673565,
0.006359384,
0.029288532,
-0.004018004,
0.0010315169,
0.007276288,
-0.01154644,
0.02415387,
-0.01984442,
-0.01222102,
-0.0075972043,
0.023813305,
0.008212839,
0.010714677,
-0.06182552,
-0.005373712,
-0.0059598754,
0.0018763784,
0.0041391663,
0.0052263523,
0.008769532,
-0.014212011,
-0.029445715,
0.024573026,
0.010243127,
0.0080949515,
-0.00391649,
-0.029917266,
-0.0050626197,
-0.018102303,
-0.0053606136,
-0.009542351,
-0.023760911,
-0.024612322
] |
Archaeal viruses display unusually high genetic and morphological diversity. Studies of these viruses proved to be instrumental for the expansion of knowledge on viral diversity and evolution. The Sulfolobus islandicus rod-shaped virus 2 (SIRV2) is a model to study virus-host interactions in Archaea. It is a lytic virus that exploits a unique egress mechanism based on the formation of remarkable pyramidal structures on the host cell envelope. Using whole-transcriptome sequencing, we present here a global map defining host and viral gene expression during the infection cycle of SIRV2 in its hyperthermophilic host S | [
-0.015813345,
-0.015119896,
-0.009742271,
-0.006485783,
-0.01185661,
0.019756483,
-0.019702096,
-0.00007988255,
-0.0052246586,
-0.015296658,
0.008946845,
0.0009543415,
0.003392459,
0.008776883,
0.00008184774,
0.001789709,
0.013386276,
-0.0096538905,
0.0006297124,
0.0041266982,
-0.021823231,
0.001963071,
0.005051296,
-0.010741653,
-0.010367735,
0.024107533,
-0.010544497,
-0.03062051,
-0.006720332,
0.00036605753,
0.007913471,
-0.014943135,
0.0041199,
-0.011101974,
-0.0071384404,
-0.016805928,
0.00494252,
-0.0009721876,
0.016071688,
0.009558711,
0.027805924,
0.006829108,
-0.0038819518,
0.0153782405,
-0.0029573538,
-0.006444992,
0.014616806,
-0.012176139,
0.006353212,
0.005177069,
0.021483306,
0.00078905263,
-0.015854137,
-0.0011005095,
-0.007084052,
-0.001657138,
0.000039277355,
-0.008851666,
-0.0030321376,
-0.024882564,
-0.013345485,
-0.0063464134,
-0.034482066,
0.03089245,
-0.011516684,
0.020218782,
-0.016425211,
0.0012840695,
0.00051541236,
0.016873913,
0.038343623,
0.034944367,
-0.0036270076,
-0.011210751,
-0.002000463,
-0.0389147,
-0.018804692,
-0.002484857,
0.002109239,
0.0066149547,
-0.004017922,
-0.0076143364,
0.0020242578,
-0.009001234,
0.02187762,
0.015813345,
0.018709512,
0.012346103,
-0.011299131,
-0.015854137,
0.015310255,
0.037881322,
0.014562419,
0.034291707,
-0.033258334,
0.023862787,
-0.013066745,
0.024678608,
0.015731763,
-0.03015821,
0.014684792,
-0.003949937,
-0.010999997,
-0.012862789,
-0.028716926,
0.01849196,
-0.009640294,
-0.013080342,
0.017064271,
-0.012006177,
-0.022067979,
0.038207654,
0.004160691,
-0.03189863,
0.049411606,
0.015813345,
0.04168849,
-0.012060565,
-0.019525334,
-0.029995047,
0.009762667,
-0.005007106,
-0.0018525952,
-0.029859077,
0.03940419,
-0.015922122,
-0.029342389,
-0.012645237,
0.010660071,
-0.007158836,
0.024148325,
-0.009273174,
0.0009738872,
-0.0025375455,
0.0075123585,
-0.00064798346,
-0.03290481,
-0.016805928,
0.029695911,
-0.017023481,
0.015255867,
0.022462292,
-0.03195302,
0.005561185,
-0.009415943,
0.0154598225,
0.011775027,
-0.006815511,
0.010721258,
-0.0016044495,
0.024461055,
-0.016873913,
0.023142144,
-0.008844867,
0.016669959,
0.019144617,
-0.02901606,
0.028091462,
-0.033394303,
-0.024678608,
-0.005258651,
0.011516684,
0.002411773,
-0.012067364,
0.0017319216,
0.017948078,
0.024936952,
0.0058331257,
-0.009973421,
-0.016289242,
-0.0048303446,
0.01043572,
-0.0343189,
0.0037561792,
0.023495667,
0.025440041,
-0.0019647707,
-0.003117119,
0.011224348,
-0.01688751,
0.007784299,
0.013488253,
0.027479596,
0.009905436,
-0.010136586,
0.031599496,
0.020218782,
0.009341159,
0.012216931,
-0.012264521,
-0.01162546,
-0.0043306537,
0.009905436,
0.0010486708,
-0.6248107,
-0.035597023,
-0.020490723,
-0.015922122,
-0.014032134,
0.003368664,
-0.0029454564,
-0.010122988,
-0.010544497,
0.01798887,
-0.013862171,
0.0019443752,
0.029288001,
-0.009851048,
-0.016370824,
-0.03094684,
-0.001816903,
-0.0022027188,
0.015187882,
-0.0067067347,
-0.028580956,
0.0048711356,
0.016221255,
0.008368972,
0.014276881,
0.036929533,
0.014276881,
-0.029967852,
-0.00645179,
0.011516684,
-0.010381332,
0.039948072,
-0.0016732845,
-0.010605683,
0.042912226,
-0.0049051284,
0.004235475,
0.028281821,
0.018750302,
0.02114338,
-0.0024270697,
-0.0040723104,
0.0039465376,
0.0027941896,
-0.0027058087,
0.0141001195,
0.00036393298,
0.002860475,
0.018179229,
-0.01849196,
0.0043238555,
0.002114338,
-0.025358459,
0.010707661,
0.036276873,
-0.00037646774,
0.017268227,
-0.02874412,
0.022489486,
0.030729286,
-0.00023263667,
0.024270697,
-0.009137204,
-0.018464766,
0.0005910459,
-0.012468476,
-0.024746593,
0.008627315,
0.007865882,
-0.0046433853,
0.02499134,
0.009626697,
0.005292644,
-0.0029454564,
-0.018872676,
0.052185398,
-0.0031987012,
-0.0050410987,
-0.027139671,
0.005574782,
0.016030898,
-0.00041810866,
-0.028608149,
-0.0040451162,
0.016262047,
-0.021048201,
-0.036684785,
0.026840536,
-0.0013588531,
0.004915326,
0.014154508,
0.032796036,
-0.017145853,
-0.01762175,
-0.006710134,
0.027221253,
-0.01802966,
0.0010444218,
-0.004660382,
-0.0139369555,
-0.004174288,
-0.013964149,
0.02489616,
0.016030898,
0.045114942,
-0.008940047,
-0.018328795,
-0.020205185,
0.029777493,
-0.029913465,
0.011924595,
-0.006101667,
-0.0039125453,
0.017322615,
0.009463533,
-0.030239793,
0.026663775,
0.0082941875,
-0.006115264,
-0.027153267,
0.03298639,
-0.0011693445,
-0.02133374,
0.004490419,
-0.006468787,
0.002357385,
-0.0019103826,
-0.03336711,
-0.030185405,
-0.014208896,
0.0013061647,
0.014127313,
0.032061797,
-0.016071688,
0.028635344,
0.0114419,
0.025440041,
0.0064245965,
-0.013773791,
-0.01839678,
-0.019715693,
0.0031001228,
0.0050376994,
-0.01688751,
-0.008804076,
-0.03323114,
-0.0016588375,
0.0017140754,
0.0005532291,
-0.015949314,
0.019606916,
0.02123856,
-0.006026883,
0.0006059176,
-0.008912853,
-0.009538316,
-0.01835599,
-0.034400485,
0.0019256793,
-0.002919962,
0.01172064,
-0.0041300976,
-0.0041266982,
-0.0022180155,
-0.013155126,
0.004374844,
-0.006944683,
0.00810383,
-0.004660382,
-0.039948072,
0.0110135935,
0.0063600102,
0.00237948,
0.015351046,
0.004843942,
0.025847953,
-0.0069820746,
0.017880093,
-0.023917174,
-0.015133494,
-0.008770084,
0.010673668,
-0.0017591157,
-0.00485074,
0.019389363,
0.008899256,
0.039757714,
-0.0047895536,
0.03872434,
0.02512731,
0.01638442,
0.034998752,
0.013522246,
0.008137822,
0.0003698817,
-0.015650181,
0.018464766,
0.002549443,
0.0067577236,
0.029505553,
0.01872311,
-0.003122218,
-0.002114338,
-0.02613349,
0.022734232,
-0.021306545,
-0.0052722483,
-0.029804688,
0.011163161,
0.015487016,
0.026881328,
-0.013495051,
-0.024379473,
-0.006380406,
-0.008640912,
0.00027937646,
0.016547585,
-0.007376388,
-0.027479596,
-0.005533991,
-0.0366032,
0.0022418103,
0.013399872,
-0.01066687,
-0.0036542015,
0.0025936333,
-0.008117426,
0.025725579,
-0.023305308,
-0.010789243,
0.0039567356,
0.0055033974,
0.031789854,
0.020354753,
0.032796036,
0.030103823,
0.018600736,
-0.008165016,
0.031327557,
0.0071928287,
-0.023740413,
0.02613349,
0.0072064255,
-0.0032343934,
0.035678606,
0.012529663,
0.031354748,
-0.0075395526,
-0.027071685,
0.010367735,
-0.018546348,
0.008851666,
-0.010415324,
0.0053300355,
0.0057379464,
-0.010306548,
0.008960443,
0.01597651,
0.023699623,
0.013964149,
-0.011346721,
-0.0017693135,
0.0093683535,
-0.0041946834,
0.016398018,
0.0067067347,
-0.008987636,
-0.0366032,
-0.023631636,
0.022299128,
-0.008946845,
-0.01029975,
0.018709512,
-0.00092799723,
0.018328795,
-0.0044326317,
0.003973732,
0.012740416,
-0.00040621124,
0.011598266,
-0.001363952,
-0.03015821,
0.011224348,
-0.0021755246,
0.014562419,
-0.02942397,
-0.02123856,
-0.015772553,
-0.0025851352,
0.004459826,
0.017390601,
0.020341156,
0.0069038915,
0.0228838,
-0.0154190315,
-0.0064721857,
0.020531515,
-0.012781207,
0.012414088,
0.0006467087,
-0.016071688,
-0.0054932,
0.009783062,
-0.016737944,
0.07059578,
-0.0018101045,
-0.003858157,
0.011428303,
-0.015636584,
0.0033992573,
-0.008430158,
-0.0060812715,
-0.0036542015,
-0.02705809,
-0.0233461,
0.033122364,
-0.01318232,
-0.017812109,
0.021170575,
0.0013800985,
-0.017417794,
-0.023495667,
-0.022815814,
-0.034590844,
0.034536455,
0.021687262,
-0.009211987,
0.031735465,
0.016533988,
-0.0023590846,
-0.029505553,
-0.04370085,
0.01148949,
-0.023196531,
-0.002687113,
-0.0053028413,
0.006750925,
-0.0008931549,
0.006825709,
0.018614333,
0.0110135935,
-0.0024134726,
-0.011108773,
0.025603207,
0.012461677,
-0.00681891,
0.0141409105,
0.03793571,
0.028037075,
-0.021564888,
0.0141817015,
0.03168108,
-0.0029896467,
-0.029369583,
-0.001034224,
0.013066745,
-0.002457663,
0.019226199,
0.0041980827,
-0.017377004,
0.006394003,
0.01725463,
-0.010027809,
0.021864023,
0.017404197,
0.013155126,
0.013610627,
-0.005642767,
-0.009218786,
-0.013066745,
-0.018600736,
0.011333124,
-0.013950552,
-0.027126074,
0.02696291,
-0.009042025,
-0.0010699163,
-0.009232383,
0.005669961,
0.008226203,
-0.0031698074,
-0.009721876,
-0.017512973,
-0.014684792,
-0.01684672,
-0.018791094,
0.03578738,
-0.017064271,
-0.019348573,
-0.013800985,
0.0074443733,
-0.0040213214,
-0.020069215,
-0.0011523482,
0.017676137,
-0.040682312,
-0.024569832,
0.010707661,
0.028281821,
0.010177377,
-0.008001852,
-0.021116186,
0.017404197,
0.015826942,
-0.0060438793,
-0.010544497,
0.0010741653,
-0.0183016,
-0.0025392452,
0.010898019,
-0.00088040764,
-0.013495051,
-0.019199006,
0.017390601,
0.013345485,
0.006410999,
0.02636464,
-0.0027262045,
-0.010496907,
0.035406664,
0.04508775,
0.009925831,
-0.023278113,
-0.0141409105,
0.0045618033,
-0.0375278,
-0.0036134105,
-0.023414085,
0.0007253165,
-0.018056855,
-0.009252778,
0.019008648,
-0.038207654,
-0.012529663,
0.023686025,
0.0009025028,
0.014684792,
-0.007981456,
0.022149561,
0.027139671,
0.0028128854,
-0.0138349775,
-0.006829108,
-0.020844245,
0.0043476503,
0.00073806377,
0.0054320134,
-0.0072472165,
-0.03236093,
0.01368541,
0.02000123,
-0.027343625,
0.00805624,
-0.0045244116,
-0.005836525,
0.018478364,
0.0004559254,
-0.0028859694,
-0.013005558,
-0.0013248605,
-0.000053591415,
-0.0039703324,
0.0037935711,
-0.032388125,
-0.0037731756,
-0.010082197,
0.021999994,
0.004911927,
-0.017771317,
-0.030702092,
-0.0026701167,
0.033856604,
-0.0047861543,
-0.0036677986,
-0.011836214,
-0.006509578,
0.0035998134,
-0.012210133,
0.0012866189,
-0.025943132,
-0.023142144,
0.0010673668,
0.044652645,
0.00942954,
0.022122366,
-0.014807165,
0.03597774,
0.01808405,
0.01802966,
0.0025511426,
-0.005850122,
-0.022108769,
-0.031273168,
-0.0062954244,
0.022435099,
-0.010966004,
-0.010680467,
-0.025508028,
0.023726815,
0.0164796,
-0.02170086,
-0.0076279333,
-0.014127313,
-0.029315196,
-0.028608149,
-0.018328795,
0.0011829416,
-0.025793565,
-0.022530278,
-0.010598884,
0.013059947,
-0.00919839,
0.0062138424,
-0.0043306537,
0.004966315,
0.001450633,
0.034889977,
0.0030661302,
0.008368972,
-0.03646723,
0.0043272544,
-0.013950552,
0.016669959,
0.023686025,
0.017608153,
0.018505557,
0.013284298,
0.008266994,
0.016588375,
0.02170086,
-0.0037357837,
-0.023400487,
0.025793565,
-0.01578615,
-0.0075463513,
-0.016452406,
-0.0025188497,
-0.052484535,
0.0049901097,
-0.0034672425,
-0.0012891684,
0.01945735,
-0.028444985,
-0.009851048,
0.030185405,
0.00008211331,
0.04361927,
-0.0019035841,
0.037419025,
0.024175517,
-0.005969096,
-0.03168108,
-0.0061628534,
0.0025477433,
-0.016805928,
0.014929539,
0.015405434,
-0.0034196528,
-0.023686025,
0.013379477,
-0.01775772,
-0.0069956714,
-0.034944367,
0.027194059,
-0.016765136,
0.00421168,
-0.0056495657,
-0.015119896,
-0.011707042,
0.021021007,
-0.011006795,
0.01487515,
-0.011516684,
0.019253394,
0.003309177,
0.016805928,
0.007893075,
0.020953022,
-0.0026259264,
-0.012237326,
0.0029352587,
-0.037174277,
-0.008341777,
-0.013576633,
-0.008199009,
0.028825702,
-0.0013435564,
0.0036915934,
-0.004568602,
0.014263283,
0.012346103,
-0.0025664393,
-0.017798511,
0.038969085,
-0.022720637,
-0.009545115,
-0.01249567,
0.014168104,
0.012284916,
0.003858157,
0.0018237015,
0.013862171,
-0.028934479,
0.015174285,
0.04095425,
0.018736707,
0.007396784,
-0.0038955489,
-0.0079270685,
0.0076687247,
-0.009660689,
0.000015177153,
-0.013250305,
-0.0324969,
-0.0058161295,
-0.0055951774,
0.007308403,
0.0140593285,
0.0025987322,
0.0034298506,
-0.012754014,
0.049928293,
-0.0219728,
-0.0037969705,
0.012896783,
-0.002879171,
-0.041307773,
-0.0011506486,
-0.002887669,
-0.03195302,
0.01085043,
-0.008919652,
-0.020028424,
-0.04696414,
0.006009887,
0.026296655,
0.0057141515,
-0.011883804,
0.020640291,
-0.020218782,
0.00074953627,
0.005292644,
-0.009300368,
0.04174288,
0.0029896467,
0.0034910373,
0.010782444,
-0.006920888,
0.011917796,
0.009789861,
0.0020038623,
-0.0111971535,
-0.026160683,
-0.022557471,
-0.0065741637,
-0.0014200398,
0.0011786924,
0.0019205804,
-0.020626694,
-0.010041406,
-0.020341156,
-0.016003704,
0.005693756,
-0.026568595,
-0.01812484,
0.014290478,
-0.0025358459,
-0.03290481,
-0.006101667,
-0.002224814,
0.01752657,
-0.01657478,
-0.03483559,
-0.0011379014,
-0.007961061,
0.03350308,
-0.019552529,
-0.0060948683,
-0.01862793,
-0.0011421505,
-0.062491946,
0.010598884,
0.005319838,
0.009742271,
0.012318908,
0.02344128,
-0.0050920877,
-0.0068359063,
-0.013474656,
0.008620516,
0.007940665,
-0.029641524,
0.025725579,
0.017417794,
-0.0000140883285,
-0.021034604,
-0.039893683,
-0.0075871423,
0.017880093,
0.020925827,
-0.01354944,
0.019334976,
-0.016275644,
0.022149561,
-0.023726815,
0.0077231126,
0.03638565,
0.023509264,
0.006502779,
-0.009919032,
-0.0343189,
0.0073152017,
-0.016873913,
-0.024909757,
0.010857228,
-0.03062051,
0.015962912,
0.028771315,
0.009980219,
-0.022761427,
0.0097150775,
0.01180902,
0.02458343,
-0.004874535,
0.026242267,
0.011972184,
0.0063328166,
-0.017186645,
0.01130593,
0.0019069833,
-0.011938192,
0.012012975,
0.026201475,
0.008967241,
-0.016683554,
-0.028934479,
0.0124752745,
-0.006091469,
0.010197772,
0.010469712,
-0.01336588,
-0.039975267,
0.0055543864,
0.0054116175,
0.0062784282,
-0.038452398,
0.008443755,
-0.0033788618,
0.004235475,
0.008940047,
0.0324969,
0.01977008,
0.023046965,
-0.017485779,
-0.003076328,
-0.008940047,
0.011088378,
0.0055135954,
-0.040355984,
0.0014268382,
0.18328795,
0.00033333967,
0.029233612,
0.033258334,
-0.020517917,
-0.015187882,
-0.00079797563,
-0.0047793556,
-0.014915941,
0.0072336197,
0.019566124,
0.013563037,
-0.0013699007,
0.0069820746,
0.0155414045,
-0.0042490717,
-0.021442516,
-0.017934483,
-0.030321375,
-0.0076687247,
0.025875147,
0.0070296642,
-0.005574782,
-0.007301605,
0.028716926,
0.006801914,
-0.03978491,
-0.020327559,
0.0015662079,
-0.0029641525,
-0.01611248,
-0.02311495,
-0.008511741,
-0.002068448,
0.011360318,
-0.0046025943,
0.0021534294,
0.005085289,
0.018695915,
0.01909023,
0.0032938803,
0.009640294,
-0.012142147,
-0.038044486,
0.012298513,
-0.019838065,
-0.010408526,
-0.0155821955,
0.00086341135,
-0.012012975,
-0.030239793,
-0.004317057,
0.004082508,
0.023726815,
0.007213224,
-0.01624845,
0.028716926,
0.007118045,
-0.0024865568,
0.025875147,
-0.032007407,
0.025059326,
-0.031110004,
0.0023998758,
0.00056725106,
0.038561177,
-0.023672428,
-0.021211365,
-0.0011837913,
-0.018546348,
0.018777497,
-0.020381946,
-0.026718162,
-0.0005570533,
0.0026650177,
-0.00288427,
0.029777493,
0.01204017,
0.023182934,
0.003671198,
0.004860938,
0.0045482065,
-0.028798508,
0.0156229865,
-0.006353212,
-0.04092706,
0.036440037,
0.010925213,
-0.021714456,
0.0012823698,
0.007981456,
-0.0032598877,
-0.0042864634,
-0.009130405,
0.009422741,
-0.0028519768,
-0.006601358,
0.008137822,
-0.004266068,
-0.024325086,
-0.016901108,
0.047752768,
-0.008368972,
0.011985782,
-0.009966622,
0.020545112,
0.0011506486,
-0.0053300355,
0.022108769,
-0.042912226,
0.0041199,
-0.014888747,
0.018559946,
-0.0057277484,
0.016302839,
0.0126384385,
0.028580956,
-0.028064268,
0.037663773,
0.019933244,
-0.015215076,
-0.01057169,
0.00023093705,
0.010075399,
-0.0064551895,
-0.021048201,
-0.032877617,
0.033203945,
-0.020681081,
-0.01688751,
0.007988255,
0.0035896157,
0.0020106607,
0.0019001849,
0.008695301,
0.012794805,
0.016234852,
-0.019987633,
-0.013800985,
-0.023400487,
-0.006404201,
0.01940296,
0.004891531,
0.009776264,
-0.0011480992,
-0.004595796,
0.02325092,
0.008640912,
-0.0019902652,
0.005901111,
-0.011652654,
-0.017662542,
-0.011571072,
0.007961061,
0.0040451162,
-0.033530273,
-0.02191841,
-0.026255863,
-0.012074162,
-0.009626697,
-0.034182932,
0.0062376373,
0.026826939,
-0.019266991,
-0.025372056,
0.0071724327,
-0.17262788,
0.0041810866,
-0.0013112635,
-0.017730527,
0.03094684,
0.0030933241,
0.018695915,
0.008579725,
-0.01460321,
0.01909023,
0.044843003,
0.020721873,
-0.025100116,
-0.02114338,
-0.0023930771,
-0.00015275413,
0.006920888,
0.011897401,
0.02874412,
-0.0061390586,
0.03410135,
-0.023645233,
-0.01473918,
-0.017907288,
0.019008648,
0.008681703,
-0.011822617,
0.019525334,
-0.0017174748,
-0.019266991,
0.0011591468,
0.031273168,
0.03410135,
-0.028580956,
0.010660071,
-0.014032134,
-0.0010809639,
0.02019159,
-0.008702098,
0.026119893,
0.027982686,
0.01231211,
0.0125568565,
-0.014657598,
-0.027574776,
0.0037085898,
-0.012414088,
-0.0035182314,
0.010184175,
0.010857228,
0.027574776,
-0.007158836,
-0.0015645082,
0.006060876,
0.029097643,
0.0020157597,
-0.0011829416,
0.0047657588,
0.008654509,
0.0032887815,
-0.014032134,
-0.02040914,
0.036276873,
-0.015799748,
0.002467861,
-0.02338689,
-0.008715696,
-0.012910379,
-0.026242267,
0.020055618,
-0.005901111,
0.0048303446,
-0.011373915,
-0.014304074,
0.01249567,
0.008389367,
-0.022788621,
0.015772553,
-0.012624842,
-0.02947836,
-0.007342396,
0.022475889,
-0.020286767,
-0.023196531,
0.01597651,
0.004306859,
-0.016370824,
0.022856606,
-0.0030967235,
0.00036881943,
0.010680467,
-0.029396778,
-0.015949314,
-0.0043136575,
0.02696291,
0.0233461,
0.024529042,
0.0126792295,
-0.015364643,
-0.0039057466,
0.008987636,
-0.001584054,
-0.010537698,
0.01839678,
0.011727437,
-0.010517302,
-0.014535224,
0.016819526,
0.060805917,
0.014657598,
-0.03551544,
-0.027166864,
0.00082771917,
-0.0023964765,
-0.028825702,
0.016833123,
-0.01684672,
-0.019266991,
0.011455497,
-0.023522861,
0.046800975,
-0.0016698851,
-0.019552529,
0.013488253,
-0.009089614,
-0.018532751,
-0.12226449,
-0.022856606,
0.007254015,
0.016098883,
-0.011265139,
0.024134727,
0.006893694,
0.008307785,
-0.030974032,
0.023373293,
-0.011707042,
-0.008742889,
0.0021160378,
0.0006229139,
0.0045482065,
0.02307416,
-0.014344865,
0.0033278728,
-0.017186645,
-0.003076328,
0.0029998445,
-0.011020392,
-0.0027245048,
0.012468476,
0.025684789,
-0.0017846101,
-0.02123856,
0.019742887,
0.01862793,
0.016547585,
0.015147091,
-0.015595793,
-0.0026803145,
0.000302109,
0.0023403887,
-0.003552224,
-0.0067135333,
-0.018097647,
0.0096130995,
-0.02448825,
0.01258405,
0.007593941,
0.006434794,
-0.0020939426,
-0.011985782,
-0.013807783,
0.00024750843,
0.0034621435,
0.008627315,
-0.008266994,
-0.015119896,
-0.023740413,
-0.024665011,
-0.009803458,
0.01835599,
-0.024773788,
0.010836832,
0.03195302,
-0.012522864,
0.0067577236,
0.0054388116,
0.0034162537,
-0.006669343,
0.013746597,
0.013386276,
-0.0096742865,
0.014997523,
-0.008532136,
0.03263287,
-0.03866995,
0.0075055603,
0.00078480353,
-0.022557471,
0.012971566,
-0.010870825,
0.013467858,
-0.03464523,
-0.009687884,
0.0029505554,
-0.016302839,
0.0041810866,
-0.014249687,
0.023740413,
-0.03899628,
0.041634105,
0.023237323,
-0.020681081,
-0.01167305,
0.0078114932,
-0.023169339,
0.014657598,
0.016914705,
-0.0016494896,
-0.030076629,
-0.01290358,
0.00590451,
-0.033802215,
0.008783681,
0.016126078,
-0.0019290785,
-0.051016055,
-0.00951792,
-0.072390586,
0.017676137,
0.0054932,
-0.016139673,
-0.005669961,
-0.02590234,
0.008858465,
0.001116656,
-0.004860938,
0.028254626,
-0.041715685,
0.009130405,
-0.009354756,
0.013542641,
-0.030810868,
-0.028934479,
0.029288001,
0.0038241644,
0.028934479,
0.010925213,
0.008668106,
0.012482073,
0.0046569826,
0.01885908,
-0.025698386,
0.009042025,
0.0024984542,
0.021075396,
-0.021129783,
-0.020069215,
-0.0038819518,
-0.034264512,
0.012216931,
0.041334968,
-0.0067543243,
-0.018220019,
0.027846716,
0.01972929,
0.011802222,
0.04503336,
-0.028961672,
-0.055747822,
0.021469709,
0.028526567,
0.009925831,
0.0043000607,
-0.004276266,
0.029043255,
0.0013223111,
-0.015310255,
0.0037833734,
0.008987636,
-0.023223726,
-0.038452398,
0.014304074,
0.015568598,
-0.0007516608,
-0.0022724036,
-0.0067475257,
-0.0141817015,
0.026459819,
0.004279665,
0.04399999,
0.0006985474,
0.009157599,
-0.01075525,
-0.034672424,
-0.0044564265,
0.011951788,
-0.03336711,
-0.017309017,
0.0038479592,
0.020082813,
-0.0012152345,
-0.004541408,
-0.0025069523,
-0.015487016,
-0.0015891528,
-0.013644619,
0.009919032,
0.012923976,
-0.027316432,
-0.019810872,
0.022312725,
0.03336711,
-0.0053470316,
0.0033125763,
0.020286767,
0.0048405426,
0.024189115,
0.0015951016,
0.028608149,
-0.0009543415,
-0.011890602,
0.0017310717,
0.0031205183,
-0.007893075,
0.005982693,
0.01771693,
0.005710752,
-0.01048331,
0.027452402,
0.01437206,
-0.021211365,
-0.024066743,
0.0006097418,
-0.012740416,
-0.02961433,
-0.010313347,
-0.005459207,
0.0062954244,
0.0037289853,
-0.014208896,
0.01437206,
-0.0055475878,
-0.0042320755,
-0.014344865,
-0.0205995,
-0.0060540773,
0.011149564,
0.014807165,
0.01845117,
0.0238084,
-0.010524101,
-0.017145853,
0.018056855,
0.007974657,
-0.015758958,
-0.0064721857,
-0.018695915,
-0.0023743813,
-0.020721873,
-0.01675154,
-0.03676637,
0.0097150775,
0.0017157751,
0.0040111234,
0.021959202,
-0.02201359,
0.08044002,
0.022897398,
-0.0139165595,
0.0075735454,
-0.06504819,
0.033938184,
0.019919649,
0.0054626064,
0.0017336212,
-0.041416552,
0.025018534,
-0.020762663,
0.010680467,
-0.027493194,
-0.01611248,
0.0016205959,
-0.0052246586,
0.008015449,
-0.015894927,
-0.0058739167,
0.016275644,
-0.022394307,
0.02994066,
0.0082941875,
-0.0045787995,
0.0004954418,
0.017200243,
-0.008042643,
0.01331829,
-0.047779962,
-0.004928923,
-0.00013172122,
-0.031708274,
-0.023087755,
-0.006512977,
-0.016343629,
-0.024107533,
-0.021524098,
0.03089245,
0.018954258,
-0.013597029,
0.00755315,
-0.021660067,
-0.022802219,
0.0010401728,
0.011571072,
-0.029097643,
-0.027044492,
-0.0065333727
] |
Hepatitis C virus (HCV) is frequently encountered in human immunodeficiency virus (HIV)-infected patients because of common routes of transmission. Previous studies suggested that HIV infection impaired the natural course of chronic hepatitis C, with a more rapid progression to cirrhosis. However, these studies did not assess the HIV infection impact on chronic hepatitis C by taking into account the risk factors for liver fibrosis progression: alcohol, sex, age at the contamination, and duration of HCV infection. We studied liver biopsy specimens of 2 groups of 58 patients that were infected by both HCV and HIV or by HCV alone | [
-0.0076183304,
-0.015223813,
0.020080017,
-0.03818158,
-0.019399121,
0.00089046464,
-0.02857195,
0.02330464,
-0.029162917,
-0.016007487,
-0.0065841386,
0.0011747067,
-0.0034911993,
-0.0025662081,
-0.011665167,
0.0034462346,
0.039055184,
-0.008768146,
0.017472057,
-0.008549745,
-0.038207274,
0.0054792883,
0.005810101,
-0.019964393,
-0.0221484,
0.034969807,
0.013515149,
-0.03162956,
-0.006763998,
-0.004653862,
0.0030014038,
-0.0021021068,
-0.017664762,
0.0002368684,
0.007926661,
-0.013977645,
-0.0057458654,
-0.003828436,
0.011755097,
0.0032374691,
0.0327858,
-0.004335896,
-0.021274798,
0.028160844,
-0.0010863829,
0.031295534,
0.013309595,
-0.015198119,
-0.010251986,
0.026747663,
0.023407416,
-0.006693339,
-0.00662268,
-0.0064428207,
0.016418593,
-0.0017889587,
-0.0068988926,
0.013849174,
-0.0057715597,
-0.020812303,
-0.015159578,
0.009609631,
-0.014607153,
0.0020940774,
-0.022533813,
0.03615174,
0.019129332,
0.008549745,
-0.008324921,
0.023317486,
0.053135607,
0.026799051,
-0.024242477,
0.012885641,
0.020876538,
0.005257676,
-0.0482794,
-0.013001265,
0.002298025,
0.019823076,
0.018653989,
-0.017086644,
0.0027219793,
0.02440949,
0.018230034,
0.008170756,
0.010515352,
0.02316332,
0.028212233,
-0.011266907,
0.0047919685,
0.00671261,
0.0027428558,
0.033248294,
-0.010046432,
-0.0021470715,
0.017677609,
0.022687979,
-0.0021470715,
-0.025103234,
-0.023831371,
0.012570888,
-0.023111934,
-0.010290527,
-0.005855066,
0.020131405,
-0.0014661753,
0.007920237,
0.0166113,
-0.01621304,
-0.020362653,
0.03751353,
0.0052127107,
-0.029496942,
0.009558243,
0.010842953,
0.007656872,
0.001055871,
-0.00331134,
-0.023831371,
0.006924587,
0.00928203,
0.029496942,
-0.00465065,
0.0058325836,
0.01679116,
-0.032323305,
0.0054600174,
-0.0044161906,
-0.00508424,
0.016559912,
0.006266173,
0.011710132,
0.0127379,
-0.016598454,
0.012275404,
-0.03309413,
-0.03640868,
-0.031346925,
-0.02184007,
0.0046763443,
0.01670123,
-0.022662284,
0.011054929,
-0.012660817,
0.008003743,
0.036048964,
0.0053154877,
-0.02082515,
-0.0055595827,
-0.006808963,
-0.0055595827,
0.03437884,
-0.02361297,
-0.0014653724,
0.011299024,
-0.01373355,
0.012127662,
-0.0065841386,
-0.02374144,
-0.009397654,
-0.010052856,
0.014016186,
-0.0018034116,
0.0058743367,
0.0098986905,
0.0059739016,
-0.010560316,
0.015891863,
-0.009127865,
-0.006140914,
0.021518892,
-0.0065166913,
0.014504376,
0.020658137,
0.009384806,
-0.017394973,
0.018371353,
-0.020748066,
-0.046403725,
-0.016405746,
0.021467505,
0.03761631,
-0.018037328,
-0.012641546,
-0.007849578,
0.03150109,
0.00881311,
-0.0007049846,
-0.02560427,
-0.0050521223,
0.016726924,
0.003097757,
-0.021544587,
-0.6380384,
-0.03951768,
0.0034205404,
0.014427293,
0.03078165,
-0.0011771156,
0.020516818,
0.022341106,
-0.014427293,
0.032014973,
0.0050746044,
0.039903093,
0.015557839,
-0.0005227164,
0.0060734665,
-0.012493805,
-0.012313945,
-0.0047662742,
-0.018782461,
0.011093471,
0.005951419,
0.008780993,
0.007727531,
0.018294271,
0.021467505,
0.016765466,
0.025552882,
-0.022264024,
0.0051324163,
0.025719894,
0.0020025417,
0.025848364,
-0.00986015,
-0.010759446,
0.046840526,
-0.0080872495,
0.0020667773,
0.005578853,
0.021852918,
0.029625412,
-0.007521977,
-0.01275717,
0.02281645,
0.00045727647,
-0.00054399436,
0.015609226,
0.011157706,
-0.0060606194,
0.004409767,
-0.00010538637,
-0.0007648039,
0.011170553,
-0.01825573,
-0.007040211,
-0.0021278008,
-0.045915537,
0.016238734,
-0.024216784,
0.0166113,
0.0064588794,
0.01453007,
0.027415711,
-0.005601336,
-0.016046029,
-0.009339842,
-0.012712206,
-0.02795529,
-0.0028665091,
0.0117294025,
0.0029468036,
0.019193567,
0.02205847,
0.0049910983,
-0.020619595,
0.016636994,
0.002524455,
0.0052544638,
-0.0010165268,
-0.025462952,
-0.011369684,
-0.0052319816,
0.012378181,
-0.017960247,
0.01007855,
0.015043954,
-0.0012734688,
-0.02410116,
0.015198119,
-0.0023189015,
0.011877144,
0.0052319816,
0.010797988,
0.0027332206,
-0.002625626,
-0.0068153865,
0.03597188,
-0.012268981,
-0.004281296,
-0.026876133,
0.0050039454,
0.005768348,
-0.023857065,
0.009204947,
-0.005655936,
0.02661919,
0.013206819,
-0.032683022,
-0.0067575746,
0.052878663,
-0.038875327,
0.008119367,
-0.01630297,
-0.008536898,
-0.010014314,
0.02661919,
-0.019257803,
0.014414446,
0.0035939761,
0.00096594135,
-0.028905975,
0.024743514,
0.021724446,
0.0037866828,
-0.0051420517,
0.0065134796,
0.011806485,
-0.008145061,
-0.021030704,
-0.016624147,
0.008588286,
0.013476608,
0.0017777175,
0.022097012,
-0.013874868,
0.019900158,
-0.0047309445,
0.010007891,
0.022983462,
-0.02020849,
-0.028366396,
-0.028212233,
-0.004229908,
0.004181731,
0.013823479,
0.0075476714,
-0.014298823,
-0.013772091,
-0.0068282336,
-0.006763998,
0.001328069,
0.024062619,
-0.015313744,
-0.014016186,
0.02471782,
-0.0064363973,
-0.0105089275,
0.038875327,
-0.024666432,
0.0075155534,
0.001898159,
0.0055884887,
0.042806536,
0.007168682,
-0.006783269,
-0.002826362,
0.0002061558,
0.02941986,
-0.004098225,
-0.008145061,
-0.02489768,
-0.0020780184,
-0.010682364,
-0.01435021,
0.036562845,
0.008408427,
-0.0033884225,
-0.007098023,
-0.021197716,
-0.008100096,
0.002042689,
0.0097766435,
-0.021750141,
0.013412372,
0.0056334534,
0.030884428,
0.0068924692,
0.010772293,
-0.005023216,
0.0150054125,
0.0420871,
-0.0027107382,
0.017883163,
-0.011106318,
0.013116889,
-0.0121983215,
0.00331134,
0.00474058,
-0.004621744,
0.0079459315,
0.03186081,
0.024293866,
-0.006789692,
0.009673866,
-0.028212233,
0.023009157,
-0.0002788222,
-0.01785747,
-0.01453007,
0.028212233,
-0.00830565,
0.001740782,
-0.003170022,
0.00050264277,
-0.01673977,
0.0065905624,
0.005578853,
0.012827829,
-0.0048722625,
0.0036871177,
0.0010261621,
-0.020619595,
-0.0030463685,
0.005839007,
-0.0060798903,
0.0075027063,
0.017382126,
-0.0056463005,
0.0074577415,
-0.0009057206,
-0.0080872495,
-0.006866775,
-0.0037160236,
0.01065667,
0.010881494,
0.005222346,
0.04314056,
-0.015159578,
-0.018525518,
0.017870316,
0.011722979,
-0.008755298,
-0.0006238873,
-0.0066034095,
0.009667443,
-0.00088885875,
0.002381531,
0.017574834,
0.009256336,
-0.022649437,
0.023561582,
-0.0004111072,
0.0183842,
-0.023548733,
-0.027544182,
0.017780386,
-0.009005818,
0.017420668,
0.0047919685,
0.026156696,
0.0098986905,
0.022032777,
-0.0025742378,
0.013900562,
-0.01625158,
0.0060895253,
0.0050938753,
-0.026516415,
-0.01577624,
-0.029085834,
0.019823076,
-0.013823479,
-0.030678876,
0.01342522,
0.008446968,
0.020439737,
0.008755298,
0.0047084624,
-0.009037935,
0.029265694,
-0.02144181,
-0.010881494,
-0.027415711,
0.008228567,
0.0054600174,
0.0014517223,
-0.023471652,
-0.005691265,
0.010804411,
-0.016431442,
-0.00022723307,
-0.0011233183,
0.017613374,
0.024782056,
-0.0012124451,
0.005691265,
-0.020581054,
0.036177434,
-0.015223813,
0.00056446943,
-0.01626443,
-0.01820434,
-0.01771615,
0.0054889233,
-0.014722777,
0.034635782,
0.01936058,
0.0028343915,
-0.012596581,
-0.009757373,
0.0075476714,
0.005280158,
-0.013489455,
-0.009378383,
0.0062340554,
0.011388954,
0.020015782,
-0.0154936025,
0.013071924,
0.001627567,
-0.023047697,
0.015146731,
-0.03168095,
-0.028546257,
-0.02844348,
0.042241264,
0.0027332206,
0.0007150214,
0.013964797,
0.03291427,
0.009082899,
0.014876942,
-0.04000587,
0.020388348,
-0.008748875,
0.022867838,
-0.03445592,
0.013373831,
0.02205847,
0.025951141,
0.017138032,
-0.002055536,
-0.03358232,
0.0008808293,
0.00067407126,
0.013335289,
-0.0097766435,
0.035098277,
0.02281645,
0.020362653,
0.0036357292,
0.0041142837,
0.035329524,
-0.0010879887,
-0.020876538,
-0.006866775,
0.010887917,
-0.014748471,
0.018217187,
-0.0016909995,
-0.023073392,
0.006808963,
-0.011151283,
0.01501826,
0.018178647,
0.02227687,
0.007277882,
0.008691063,
0.013836327,
0.019026555,
0.0066869156,
-0.015480756,
0.0011522243,
-0.0012357305,
-0.0183842,
0.014607153,
-0.0021904306,
-0.0008511204,
-0.006105584,
-0.014491529,
-0.008819534,
0.0024377373,
-0.0063593145,
-0.0015793904,
0.0036582118,
0.0008800264,
-0.026041072,
0.0065488094,
-0.0056623593,
0.00039705567,
-0.01811441,
-0.016431442,
-0.04386,
-0.016161652,
-0.0038444947,
0.013656467,
-0.011864297,
0.020850843,
0.0115880845,
-0.020696677,
0.001227701,
0.007425624,
-0.0036614235,
0.016778313,
0.010290527,
-0.015891863,
-0.018242883,
-0.0071172933,
-0.0163929,
-0.005707324,
-0.0030784863,
-0.01896232,
-0.002429708,
-0.010797988,
0.012821406,
0.012108392,
0.007252188,
-0.009513278,
0.0085561685,
-0.003211775,
0.0014910665,
0.03371079,
0.018821001,
-0.016071722,
-0.0044740024,
0.009943656,
-0.02462789,
0.016315818,
-0.022379648,
-0.007053058,
-0.027801124,
-0.011568814,
-0.014118963,
-0.012487382,
-0.034481615,
0.028366396,
-0.011157706,
0.002685044,
0.000037863818,
0.015365131,
0.036485765,
-0.017651916,
-0.0073613883,
0.02826362,
-0.012146933,
-0.016225887,
-0.0016155228,
0.025154622,
-0.009616055,
-0.009975773,
0.00861398,
0.019925851,
-0.02303485,
-0.041727383,
-0.02006717,
-0.027390018,
0.042318348,
-0.0024762785,
-0.0137849385,
-0.031655256,
0.011523848,
-0.0065455977,
-0.000957109,
-0.009025088,
-0.023073392,
-0.014542917,
-0.005896819,
0.013412372,
-0.01541652,
0.017305044,
-0.035509385,
-0.0036036116,
0.04000587,
-0.0131939715,
-0.0068346574,
0.004663497,
-0.0052737347,
-0.0052287695,
0.02312478,
-0.015544991,
-0.012179051,
-0.007952355,
-0.008177179,
0.042266957,
0.022752214,
0.011793638,
0.008402003,
0.00399866,
0.0038091652,
0.023831371,
-0.005993172,
-0.01673977,
0.020799454,
-0.008132215,
0.015198119,
0.020837996,
0.0031138158,
-0.00671261,
-0.010913611,
0.016315818,
0.014748471,
-0.016431442,
-0.025064692,
-0.014594305,
-0.020696677,
-0.01550645,
0.005411841,
0.0030335216,
0.0016717289,
-0.040082954,
-0.013707856,
-0.02006717,
-0.01324536,
0.0199387,
-0.022842145,
0.019129332,
0.011819332,
-0.0022225482,
-0.0032792222,
-0.0024810962,
0.00022823676,
0.0023879546,
-0.0020314476,
0.008530474,
0.009705984,
-0.0011666772,
0.0021647364,
0.004666709,
-0.02710738,
0.017600527,
0.01789601,
-0.016559912,
-0.02232826,
-0.013990492,
-0.02250812,
-0.0012060215,
-0.025835518,
-0.016200192,
-0.010971423,
-0.05149118,
0.0013545661,
-0.015879016,
0.0073999297,
0.003870189,
-0.010412575,
0.014465835,
-0.0012574099,
0.034404535,
-0.030087909,
0.044091247,
0.020375501,
-0.013348137,
-0.028880281,
-0.013656467,
0.022983462,
0.0019222473,
0.04509332,
0.03296566,
-0.005270523,
-0.016598454,
0.01688109,
0.023356028,
-0.005752289,
-0.055396695,
0.018615449,
0.0064042793,
-0.013643621,
-0.009057205,
-0.008202873,
-0.019399121,
0.019476203,
-0.005909666,
0.007804613,
0.0071494114,
-0.004586415,
-0.0034012697,
0.015262355,
-0.012802135,
0.012320369,
-0.011536696,
-0.031372618,
-0.04373153,
-0.030807346,
-0.0012766806,
0.0058647012,
-0.0075476714,
0.007406353,
-0.008350615,
-0.00917283,
-0.0014605547,
-0.015339438,
0.0048979567,
0.0072971527,
-0.010162056,
0.02906014,
0.012969147,
-0.014645694,
0.018525518,
0.01501826,
-0.003468717,
-0.0031603866,
0.005023216,
-0.010046432,
-0.012410299,
0.0127379,
0.03445592,
0.023150474,
-0.0040725307,
0.02520601,
-0.0065006325,
-0.005000734,
-0.018551212,
-0.026516415,
0.0332226,
-0.028392091,
-0.015686309,
-0.023767134,
0.017510597,
0.007804613,
0.0018788883,
0.009661019,
-0.0031346923,
0.040211424,
-0.039235044,
0.0022321837,
-0.0025324847,
0.0036357292,
-0.015879016,
0.0018901296,
-0.033993427,
-0.027801124,
0.008421274,
-0.007348541,
-0.022970615,
-0.027775431,
0.004313414,
0.015827628,
0.021390421,
-0.0074448944,
0.040057257,
0.008498357,
-0.0071494114,
-0.008620404,
-0.005610971,
0.03681979,
-0.0030206745,
-0.0009828032,
0.00819645,
-0.010104245,
0.010219868,
-0.01224971,
-0.00067768455,
-0.0058165244,
-0.015185272,
-0.035766326,
-0.010052856,
0.018898085,
-0.025373023,
-0.020028628,
0.014748471,
-0.008524051,
-0.008607557,
-0.008819534,
0.003468717,
0.006365738,
-0.04093086,
0.008691063,
0.015699156,
0.0102648325,
0.004724521,
-0.0046185325,
-0.0036582118,
-0.016547065,
-0.014427293,
0.006050984,
-0.019681757,
0.041573215,
0.020182794,
0.016534219,
-0.029651107,
-0.014170351,
-0.043166257,
0.005264099,
0.0142731285,
0.023677206,
0.009641749,
-0.00036734677,
-0.0020362653,
0.026028225,
-0.0046474384,
0.023702899,
-0.0150054125,
-0.021236256,
0.0010759446,
0.004313414,
0.02826362,
0.020786608,
-0.015583532,
-0.014491529,
0.018294271,
0.028058067,
-0.0005636665,
0.006924587,
0.001996118,
-0.006706186,
-0.010329069,
0.015968945,
-0.0007322847,
-0.023535887,
0.0052030757,
-0.027390018,
-0.013823479,
0.027518488,
-0.00968029,
-0.011459613,
-0.004711674,
-0.008736028,
0.019077944,
0.00005806287,
0.019065097,
-0.038669772,
0.02254666,
-0.022957768,
-0.008536898,
-0.00474058,
0.015712004,
-0.0025501493,
0.0057876185,
-0.008858075,
0.010207021,
0.019900158,
0.0013417191,
-0.008980123,
0.019630369,
0.0078431545,
-0.017639069,
-0.015866168,
-0.009057205,
-0.012005615,
-0.0026657733,
-0.008145061,
-0.029599719,
-0.021608822,
0.024525113,
-0.0021888246,
0.01771615,
-0.0086782165,
0.010284103,
-0.0059449957,
-0.01727935,
-0.0058454303,
0.01422174,
-0.011973497,
-0.006070255,
0.0071301404,
-0.0006853125,
0.004930075,
0.009384806,
-0.005999596,
-0.0009025088,
0.0054857116,
0.1825316,
-0.01541652,
0.02388276,
-0.020041477,
-0.021608822,
0.013168277,
0.03347954,
-0.0012839071,
0.008736028,
0.030884428,
0.02042689,
0.0028070915,
0.000102877166,
0.0047662742,
-0.019951547,
-0.023857065,
-0.031758033,
-0.013258208,
-0.023857065,
-0.021159174,
-0.0031732337,
0.0021037126,
0.0014942783,
-0.009783067,
0.019296344,
-0.0040596835,
-0.028469173,
0.018718224,
0.022431036,
0.002241819,
0.0018307117,
-0.022598049,
-0.024679279,
0.0031668101,
-0.012570888,
0.007656872,
-0.01771615,
-0.01945051,
-0.0013553691,
-0.026876133,
-0.018988013,
0.029034447,
-0.031655256,
-0.010669516,
0.0016926054,
0.0028038796,
0.010027162,
-0.029471248,
0.012172627,
0.00037437252,
-0.02844348,
-0.04147044,
0.007040211,
0.029882355,
-0.0065745036,
0.010155632,
0.02068383,
0.004111072,
-0.004008295,
0.013630773,
0.00017755094,
0.009474737,
0.0009530942,
0.0075284005,
-0.02281645,
0.029805273,
-0.009840879,
-0.023420263,
-0.0055178297,
-0.017549139,
0.010406151,
-0.032631636,
-0.028109455,
0.008408427,
-0.004692403,
-0.0033017048,
0.032554552,
0.01541652,
0.023484498,
0.03995448,
-0.00035168938,
-0.0030190686,
-0.033017047,
0.0108750705,
-0.0049043805,
-0.024242477,
0.03340246,
0.010007891,
-0.02596399,
0.023895606,
0.010136362,
-0.009686713,
-0.015403673,
-0.015069649,
0.009037935,
0.016508523,
-0.013412372,
-0.025334481,
0.028340703,
-0.0028857798,
-0.017292196,
0.075284004,
0.00063031085,
-0.00051830016,
-0.0042748726,
-0.00029949803,
-0.015968945,
-0.0030158567,
-0.0036421528,
-0.016071722,
0.007521977,
-0.026644886,
0.0067190332,
-0.03034485,
0.010746599,
0.03556077,
0.0048433566,
-0.014568611,
0.011517425,
0.008517628,
-0.0054214764,
-0.015660616,
0.007438471,
0.0060798903,
-0.005119569,
-0.020131405,
-0.0034301756,
0.01342522,
-0.023227558,
-0.04938425,
0.017947398,
-0.006860351,
-0.011189824,
-0.01355369,
0.020940773,
-0.0058068894,
0.008010167,
-0.019334886,
-0.009892267,
0.0031106041,
0.0044932733,
-0.012101968,
0.014555764,
0.002298025,
-0.004239543,
-0.001412378,
0.00819645,
0.009063629,
-0.02180153,
-0.0017809293,
-0.035766326,
-0.014607153,
0.004910804,
-0.011491731,
0.0221484,
-0.023009157,
0.005026428,
-0.005309064,
-0.003481564,
0.00019752416,
-0.032220528,
0.026721967,
0.011928532,
-0.0095518185,
-0.011395378,
0.005938572,
-0.15837905,
-0.007900966,
0.0044322493,
-0.017793234,
0.02365151,
-0.016893936,
0.0063111377,
-0.002696285,
0.009596784,
0.015146731,
0.027004605,
-0.005109934,
-0.037025344,
-0.013951951,
0.024820598,
-0.00091856765,
-0.02636225,
0.020940773,
0.03848991,
-0.013097619,
0.037693392,
-0.03823297,
0.001627567,
-0.0081900265,
-0.00602529,
-0.015172425,
-0.028828893,
-0.011748673,
-0.010528198,
0.0080872495,
0.0062982906,
0.027569877,
0.027133076,
-0.023779983,
0.0060991608,
-0.030550404,
-0.003314552,
0.0017761115,
0.0031668101,
0.016662689,
0.050925903,
0.026041072,
0.00948116,
0.026156696,
-0.021865765,
0.026208084,
0.018782461,
0.0006572095,
0.025552882,
0.01501826,
0.01762622,
-0.0062019373,
0.03553508,
-0.0012260951,
-0.0038990949,
-0.017472057,
-0.005077816,
-0.008228567,
0.0020346595,
0.018050175,
-0.013682161,
-0.018281423,
0.0058582774,
0.0009057206,
0.021364728,
-0.011767943,
0.006706186,
0.01065667,
-0.015056801,
0.0134380665,
-0.029317083,
-0.009673866,
-0.0130526535,
-0.016983867,
0.024692126,
0.017048102,
-0.03779617,
0.024936222,
-0.006006019,
-0.001071127,
-0.022867838,
0.013900562,
-0.02520601,
-0.029933743,
-0.037898947,
-0.004621744,
0.0097766435,
-0.0024602197,
-0.020401195,
-0.022264024,
0.023291793,
-0.01856406,
-0.012827829,
0.0020169946,
-0.028854586,
0.02538587,
0.037976027,
0.0069117397,
-0.0023092662,
-0.007971626,
0.03252886,
-0.007592636,
-0.013566538,
0.017253656,
0.019193567,
-0.016341511,
-0.03016499,
-0.0044611553,
0.050823126,
0.0072907293,
-0.013797785,
0.021891458,
0.007836731,
0.008626828,
-0.01453007,
0.0005981931,
-0.0135408435,
-0.008986547,
-0.0068988926,
-0.02808376,
0.062334128,
0.013097619,
-0.028417785,
0.012037733,
-0.0031106041,
0.016431442,
-0.14491528,
-0.029008752,
0.019257803,
0.019257803,
0.027287241,
0.045838453,
0.014337364,
-0.015480756,
-0.0044707907,
0.0027364322,
-0.02870042,
-0.002126195,
-0.0110742,
-0.0252574,
0.026156696,
0.0024746726,
0.012275404,
0.008151485,
-0.028828893,
0.026208084,
-0.0045318147,
-0.01205058,
-0.003956907,
-0.021968542,
0.003340246,
0.00671261,
-0.017394973,
0.008382733,
0.013502303,
0.021737292,
0.006783269,
-0.005710536,
-0.010065703,
0.012089121,
-0.0123396395,
-0.0006371359,
0.0025774494,
0.0013489455,
0.037976027,
-0.040108647,
0.015390825,
0.01158166,
-0.0046731327,
-0.0011120772,
0.021159174,
0.0007832716,
-0.02480775,
0.0054728645,
0.014941177,
-0.022007082,
-0.025617117,
-0.024319561,
-0.03401912,
-0.03016499,
0.012782864,
-0.034121897,
-0.007637601,
0.04612109,
-0.021287644,
0.001941518,
0.0015689521,
-0.015943252,
-0.012024886,
0.026644886,
0.025488647,
-0.04735441,
-0.00047735006,
0.00026878543,
0.022161247,
-0.037153814,
-0.017574834,
-0.043089174,
-0.0239213,
-0.016110264,
-0.0018018058,
0.036460068,
0.015082495,
-0.023664359,
0.0037031765,
-0.0012445628,
-0.017176572,
-0.0057233833,
0.020542514,
-0.000984409,
0.009744525,
0.005023216,
-0.007592636,
-0.0020683832,
-0.000706189,
0.0023478076,
-0.0131939715,
0.038155887,
0.0009362324,
-0.002696285,
-0.002827968,
0.00055563706,
-0.0068346574,
-0.014285975,
0.010624552,
0.031346925,
-0.02560427,
0.011626625,
-0.03836144,
0.006327197,
-0.0016123111,
-0.0093912305,
0.00016721303,
0.0012975571,
0.010528198,
-0.015660616,
0.019951547,
-0.00011582464,
-0.025989683,
0.005999596,
-0.024756363,
0.012082698,
-0.019951547,
0.017831774,
0.040751003,
0.019463357,
-0.007322847,
0.02024703,
-0.003227834,
0.024794903,
-0.000023812301,
0.027441405,
-0.007496283,
0.029908048,
-0.0030014038,
0.029702496,
-0.017639069,
-0.00010759446,
0.0020956832,
-0.0018965531,
-0.012268981,
-0.011433919,
0.025488647,
-0.007335694,
0.014298823,
0.022302566,
0.015840475,
0.0509516,
-0.0076054833,
-0.018576907,
0.01820434,
0.010521775,
-0.003626094,
0.0091921,
-0.0065745036,
0.02055536,
0.013014113,
-0.001740782,
0.014247434,
0.016816854,
-0.021583129,
0.011722979,
-0.027903901,
0.000055704222,
0.007554095,
-0.038515605,
-0.009847302,
-0.01785747,
0.012346063,
0.01116413,
-0.004265237,
0.022135554,
0.014427293,
-0.008870923,
-0.036485765,
-0.00088885875,
0.033273987,
0.0039601186,
-0.02795529,
0.0115880845,
-0.012956301,
-0.0032422869,
-0.0011859479,
0.008042284,
-0.00023245222,
0.024846291,
-0.0034044816,
-0.017035255,
0.008292803,
0.0000962027,
-0.020966467,
0.0035168936,
0.033787873,
0.0054568057,
0.0063015027,
0.018294271,
0.005655936,
0.006253326,
0.0045286026,
0.021069244,
-0.0020924713,
0.0199387,
0.015480756,
0.013065501,
-0.0074577415,
-0.002611173,
-0.0050296397,
0.05781195,
-0.0063304086,
-0.009076476,
-0.014966872,
0.00051990605,
-0.020632442,
0.0063175615,
-0.027030298,
-0.0482794,
-0.007836731,
0.0028327855,
0.014684236,
0.0014324517,
-0.011825755,
-0.012892065,
0.000009302856,
-0.0046056854,
-0.023407416,
0.011401801,
-0.010226292,
0.019257803,
0.007104446,
0.045375958,
0.004300567,
-0.013579384,
0.010669516,
0.000058966183,
0.024704974,
-0.016688382,
-0.0039183656,
0.004085378,
0.013656467,
-0.002800668,
-0.005578853,
-0.024383796,
-0.028828893,
-0.038027417,
0.028212233,
-0.006706186,
-0.0006367344,
0.058171667,
0.00081017026,
-0.02918861,
0.011408225,
-0.028289314,
0.017138032,
-0.01205058,
0.0066547976,
-0.030267768,
-0.012044156,
0.021377575,
-0.013695009,
0.0040243543,
-0.048099544,
-0.015403673,
-0.00013499492,
0.00029789214,
0.019257803,
0.009956502,
-0.0030961512,
0.018499823,
-0.010341915,
0.023240404,
-0.00041632634,
-0.012898489,
0.0025774494,
0.036203127,
-0.033556625,
-0.012917759,
-0.027621266,
-0.002842421,
0.011093471,
-0.018178647,
-0.0154936025,
0.01114486,
-0.021056397,
-0.021595975,
0.00055724295,
0.02055536,
0.0022113072,
-0.019591827,
-0.0051645343,
-0.022842145,
-0.030242074,
-0.019463357,
-0.025925448,
-0.041701686,
-0.012731476,
-0.00016319832
] |
The purpose of this study was to examine the relation of leptin to metabolic and dietary factors in college-age adults. Young adult women and men (n = 32) were recruited and underwent testing for measurement of body mass index, body composition, peak oxygen consumption (VO2peak), dietary intake, and plasma levels of leptin and insulin. Ln leptin was significantly greater for women than for men (2.1 versus 1.2 ng/mL, respectively). This difference remained significant even after adjusting ln leptin for fat mass and fat-free mass as covariates in separate analyses. VO2peak was higher for men than for | [
-0.0106830485,
-0.012402535,
0.0068125683,
-0.037894093,
-0.003962012,
-0.0032755246,
-0.009035479,
-0.021823755,
-0.024870452,
-0.026138818,
0.01235677,
0.02636111,
0.005900521,
-0.002316077,
-0.02099997,
-0.0075055934,
0.03907093,
-0.009283923,
0.005714189,
-0.009499676,
-0.02271292,
0.0038018315,
-0.0063026063,
0.008643201,
-0.001583824,
-0.0132001685,
0.024033591,
-0.036089614,
0.024661236,
-0.01990159,
0.029525489,
-0.007852106,
-0.01919549,
-0.00003090214,
-0.014187402,
-0.004471974,
-0.019535465,
-0.020803832,
0.0196793,
-0.026256502,
0.011546061,
0.0064987456,
-0.009800422,
0.016527997,
-0.010532675,
-0.014056643,
0.0186463,
-0.03106845,
-0.00019716076,
0.026060361,
-0.022516781,
0.0047334926,
-0.0058089895,
0.01284058,
-0.022935212,
-0.0018469775,
0.0011000141,
0.012056023,
0.011493757,
-0.020986894,
-0.005197689,
-0.0047792587,
-0.026936451,
0.00174237,
0.009100859,
-0.004413132,
-0.009604283,
0.03676956,
0.014867351,
0.010166549,
0.02632188,
0.027250273,
-0.020123882,
0.02858402,
0.021117654,
-0.008996251,
-0.012088713,
-0.003110441,
-0.001285529,
-0.014135099,
0.015691137,
-0.02148378,
-0.019457009,
0.012958263,
-0.014867351,
-0.0026119205,
-0.0015421445,
0.016920276,
0.014566605,
-0.0077540367,
-0.010401916,
-0.0022016626,
0.020843059,
0.009310074,
-0.030257741,
0.023301337,
-0.0019597576,
0.0026282654,
0.0039816257,
-0.0045438916,
-0.0145927565,
0.0015061856,
0.006184923,
-0.0065739322,
-0.04098002,
-0.016501846,
-0.028740931,
-0.01684182,
0.015442694,
-0.000987234,
-0.006943328,
0.0387048,
-0.00044335632,
-0.028819388,
-0.0060835844,
-0.005916866,
-0.0011956319,
0.009852726,
-0.024020515,
0.01345515,
0.03287293,
0.0033180215,
0.017861744,
-0.00035121175,
-0.0019434126,
0.004746569,
-0.01519425,
-0.008545131,
-0.0009316612,
0.011532986,
-0.009015866,
-0.015769592,
0.026426489,
0.0013092292,
-0.026674932,
0.029603943,
0.0091858525,
-0.011395688,
-0.018724756,
-0.015978808,
-0.01835863,
0.008813188,
-0.01871168,
-0.0060345493,
-0.023235958,
0.032820627,
0.014278934,
0.006877948,
0.0021640693,
-0.014108947,
0.00071018736,
-0.020973818,
0.020411553,
0.009663125,
0.011997181,
0.019051654,
0.003422629,
0.021222262,
-0.027721008,
-0.014514301,
-0.0069041,
-0.025537325,
-0.00887203,
0.0061064675,
0.0011474143,
0.011068789,
0.023235958,
-0.0024599126,
0.0060214736,
-0.006851796,
-0.002213104,
0.032088373,
-0.023719767,
0.01703796,
-0.00067790615,
0.022176806,
-0.0045406227,
0.005462477,
-0.004141806,
-0.028270198,
-0.015272706,
0.057847988,
0.024072818,
0.024661236,
-0.008832802,
0.022438325,
0.017704831,
-0.012670592,
0.013115175,
-0.033762094,
0.020568464,
0.03200992,
-0.003322925,
-0.024818147,
-0.65651715,
-0.0034193601,
-0.012311004,
0.00877396,
0.003651458,
0.008630125,
0.021509932,
0.020986894,
0.0036743411,
0.029237818,
0.016475692,
0.006247034,
-0.012461377,
-0.03682187,
-0.010467296,
-0.0359327,
-0.042287614,
-0.014331237,
-0.0023683808,
-0.02119611,
-0.04940093,
0.0075644352,
0.00029870367,
0.019796984,
0.025694236,
0.014174326,
0.013311314,
0.00906817,
0.009434296,
0.009636973,
0.010467296,
0.026570324,
0.008643201,
0.027982526,
0.042183004,
-0.04014316,
0.00074328587,
0.021588389,
-0.0003291461,
0.021849908,
-0.011657206,
-0.014605832,
0.016946428,
0.016527997,
-0.0138082,
0.020306945,
-0.0068256445,
0.024242805,
0.035801943,
-0.007721347,
0.012866732,
-0.0026854726,
-0.019980047,
-0.009434296,
0.033892855,
-0.0007882344,
0.021156883,
-0.024268957,
-0.0016271381,
0.004919825,
-0.0012136113,
-0.0018093842,
-0.0041091163,
-0.01822787,
-0.01677644,
0.01345515,
-0.0035599265,
0.016972579,
0.004393518,
-0.027537944,
0.035305057,
0.027224122,
0.015717288,
0.020803832,
0.039933942,
0.00037123432,
0.014867351,
0.039698575,
-0.019470084,
-0.00031259685,
-0.0018012117,
0.0065052835,
-0.0026053824,
-0.004919825,
0.0052826824,
-0.012507143,
0.011310694,
0.004383711,
0.006188192,
0.007714809,
0.0196793,
-0.003087558,
-0.0059691695,
-0.013108637,
-0.013481301,
0.022320641,
-0.032271437,
0.0031267859,
0.020790756,
-0.008303226,
-0.032428347,
-0.0048773284,
-0.0033932081,
-0.0014555163,
0.04098002,
0.013925884,
-0.004651768,
0.012029871,
0.029237818,
-0.015900351,
0.0005990418,
-0.022987515,
-0.0036089614,
0.004383711,
-0.0067864163,
-0.023379793,
0.011846808,
-0.0057436097,
-0.0042431448,
-0.016881047,
0.020869212,
0.005413442,
0.020751528,
0.002616824,
-0.008996251,
0.02368054,
-0.010637282,
0.0040110466,
-0.010820346,
-0.01490658,
-0.009042017,
0.021666843,
0.018894743,
-0.013664365,
0.008545131,
0.013507453,
0.019574692,
-0.01016001,
0.0013966745,
-0.025171198,
-0.010238467,
0.0005757503,
0.009976948,
-0.020829983,
0.00040984922,
-0.023183653,
0.006459518,
0.016057262,
-0.0016835282,
-0.0030336196,
-0.017273325,
-0.018254021,
-0.021026123,
0.0036874171,
0.017887896,
-0.014475074,
0.0031594757,
-0.010754966,
-0.0055801603,
0.0030140057,
-0.019836212,
0.016985655,
0.0043019867,
-0.022503704,
-0.0009823305,
-0.027433336,
0.012409073,
0.023615161,
-0.008342454,
-0.025249654,
0.019548541,
-0.009898492,
-0.0055474704,
0.0033180215,
-0.007381372,
-0.0040731574,
-0.024948906,
-0.0025285613,
-0.012539833,
-0.010303847,
0.024622008,
0.014305086,
-0.034755867,
0.022909058,
0.02997007,
0.017338706,
-0.001845343,
0.019287022,
0.0021346484,
0.018907819,
-0.0193524,
0.012820966,
0.0044948566,
0.023249034,
0.012350232,
-0.011278004,
0.011984105,
-0.014671212,
0.025275806,
0.0025449062,
0.026962603,
-0.017521769,
0.004383711,
-0.014684289,
0.025628855,
-0.00619473,
-0.002239256,
-0.0038312525,
0.011931801,
0.01699873,
0.010532675,
0.004432746,
-0.014435845,
0.001851881,
-0.019548541,
0.018986275,
-0.013638212,
0.0062731854,
-0.0067144986,
-0.016096491,
-0.0013312949,
-0.023693616,
0.01871168,
-0.013625137,
-0.007884796,
0.019718528,
0.017508693,
-0.00067095953,
-0.0145927565,
-0.0066196984,
-0.005164999,
0.0031987035,
-0.0022425249,
0.025916526,
0.003229759,
-0.022085274,
0.0063876,
-0.020986894,
-0.0067798784,
0.0030221783,
0.009735042,
0.023562856,
0.015442694,
-0.026413413,
0.0084862895,
-0.016462617,
0.00829015,
0.008074397,
-0.0011833732,
0.034729715,
0.02203297,
0.023589008,
-0.00441967,
0.005972439,
-0.004122192,
0.010029252,
-0.008584359,
-0.0050832746,
0.015821896,
0.02145763,
0.02242525,
0.008107087,
-0.021562237,
0.006407214,
0.008983175,
0.01580882,
0.003067944,
0.0018191912,
-0.005916866,
-0.02326211,
-0.02167992,
-0.0057468787,
0.02552425,
-0.032376043,
0.027014906,
0.002477892,
0.029734703,
-0.00938853,
0.03326521,
0.04043083,
-0.001974468,
-0.01741716,
0.026988754,
0.022359869,
-0.011153783,
-0.02955164,
-0.0030401577,
-0.0114872195,
0.018371705,
0.0032804282,
0.005714189,
-0.008675891,
-0.00084339856,
-0.017665604,
-0.023798224,
0.01684182,
0.02284368,
-0.01994082,
0.0345205,
0.01187296,
0.00877396,
0.0026495138,
-0.018580921,
-0.008022093,
0.05329756,
0.011454529,
0.0047661825,
-0.021627616,
0.0031284203,
-0.012500606,
0.014514301,
-0.00017744469,
0.0007212202,
0.013154402,
0.0064791315,
0.013860504,
-0.008800113,
0.0029012258,
0.010401916,
-0.010068479,
-0.017861744,
-0.029630097,
-0.022412173,
0.00538729,
0.041215386,
0.026766464,
0.019666225,
0.01712949,
0.0004834014,
0.001945047,
-0.01325901,
-0.0057566855,
0.014605832,
0.011794504,
-0.025419641,
-0.007093701,
-0.009434296,
0.0036122303,
0.0050734673,
-0.0031741862,
-0.0047629136,
-0.058946367,
0.0025089474,
0.0027998872,
-0.008532056,
0.012605213,
0.02790407,
0.03465126,
0.016018035,
0.007152543,
-0.009127011,
0.04236607,
0.0011531351,
-0.02603421,
0.00014117936,
0.013206706,
0.00072734954,
0.015494997,
-0.0072571505,
-0.010879188,
-0.0007698464,
-0.021104578,
0.019247795,
0.006309144,
0.03509584,
0.023902832,
-0.0020463858,
0.027041059,
-0.01325901,
-0.015364238,
0.0015004649,
0.038051005,
0.019509314,
-0.008715118,
0.026635705,
-0.0038279835,
-0.007061011,
-0.014161251,
-0.021248413,
0.0033114837,
0.006436635,
-0.025785767,
-0.0062274197,
-0.00893741,
-0.0013590812,
-0.016331857,
0.043621358,
-0.007636353,
-0.0070217834,
-0.0011057347,
-0.010329998,
-0.0028865153,
-0.005403635,
0.027825614,
0.0009945892,
-0.020202339,
0.010728815,
-0.007610201,
0.006390869,
0.014409694,
0.00883934,
-0.026178045,
0.0021951245,
0.0134159215,
-0.015416541,
0.0045177396,
-0.005400366,
-0.01990159,
-0.000033966815,
0.0012601943,
0.0022016626,
-0.0055311257,
-0.02671416,
-0.02300059,
0.002732873,
0.0052630687,
0.013481301,
-0.013481301,
0.0016426658,
0.011389149,
-0.018371705,
0.010127321,
0.022150654,
-0.0058678314,
0.010467296,
-0.0040764264,
-0.017848667,
-0.0032379313,
-0.013677441,
0.014985035,
-0.009990023,
-0.014370466,
0.0014416232,
-0.0035403126,
0.014540453,
-0.0021150345,
-0.0018633225,
-0.0007649429,
0.03713569,
0.03577579,
-0.015782667,
0.0048086797,
0.045268927,
-0.03122536,
-0.030728476,
-0.0062535717,
0.023902832,
-0.011997181,
-0.03577579,
0.0048871352,
-0.014985035,
-0.022856755,
-0.01671106,
0.007237537,
0.010375764,
0.014278934,
-0.012964801,
-0.025158122,
-0.046498068,
-0.00067994924,
-0.029473184,
0.0065020146,
-0.001493927,
-0.0150765665,
-0.027407184,
-0.012121403,
0.002494237,
-0.038312525,
0.058109507,
-0.02913321,
-0.011997181,
-0.0052074958,
-0.028897842,
0.00938853,
-0.003971819,
0.0065248976,
-0.02154916,
0.0055932365,
-0.0004445822,
-0.022529857,
-0.045033563,
-0.0031513032,
0.04877328,
-0.00094964064,
0.017351782,
0.011206087,
0.0067537264,
0.0010820347,
-0.0019761026,
0.016331857,
-0.0044588977,
0.007930562,
-0.008590898,
0.029891614,
0.025851147,
-0.015338086,
0.012474453,
0.01838478,
-0.008617049,
0.02574654,
-0.019862363,
-0.006655657,
0.003429167,
-0.034154374,
0.012735972,
-0.0029404536,
-0.0146450605,
0.015298858,
-0.04181688,
-0.04709956,
0.019640073,
0.010604593,
0.012781738,
-0.010748428,
0.018698605,
-0.054762065,
0.0062731854,
-0.00094800617,
-0.02706721,
0.006701423,
-0.017482542,
0.0015560377,
-0.0011237141,
0.026204197,
-0.029107058,
0.017077187,
0.006247034,
-0.0033637874,
0.0036220374,
-0.0014931097,
-0.0029224742,
0.018084034,
-0.0045667742,
-0.022595236,
0.016645681,
-0.0012912498,
-0.016593376,
-0.026936451,
-0.0055278568,
0.007917486,
-0.013690516,
0.011899112,
-0.013572833,
-0.0084536,
0.019156262,
-0.0048577143,
0.017757136,
-0.008545131,
0.0524607,
0.0003452867,
-0.0048119486,
-0.029159361,
0.012363308,
-0.0009717063,
0.00616204,
0.015481921,
0.0131478645,
-0.00787172,
0.01855477,
0.0046092714,
0.007302916,
-0.02981316,
-0.017338706,
0.0245174,
-0.0186463,
0.0047956035,
-0.008009017,
-0.009179315,
-0.030911539,
-0.0040895026,
-0.02132687,
-0.0016418486,
0.008237846,
0.008172466,
-0.007982866,
0.03051926,
0.003170917,
0.0042464137,
-0.0038933633,
0.008447061,
0.000987234,
-0.013030181,
-0.03454665,
0.018489389,
0.01816249,
0.031303816,
0.00932315,
0.0129844155,
0.008499365,
0.00935584,
-0.004749838,
0.0014138367,
-0.014370466,
0.027825614,
0.004896942,
-0.0014685923,
-0.0010493448,
-0.019117035,
0.028923994,
0.006672002,
-0.0040829643,
-0.03119921,
-0.005351331,
0.011853346,
0.022869831,
0.008545131,
-0.02983931,
-0.010088093,
-0.03962012,
-0.0020022544,
-0.036926474,
-0.013285162,
0.011827194,
-0.03784179,
0.024948906,
-0.024700465,
-0.01177489,
0.008172466,
0.03010083,
-0.0026331688,
-0.029237818,
0.030466957,
-0.032689866,
0.017090263,
-0.006217613,
0.004651768,
-0.019796984,
0.031539183,
-0.037214145,
-0.009708891,
0.015625756,
-0.0064824005,
-0.0317484,
-0.021261489,
-0.0025285613,
0.0021281103,
0.007061011,
0.014370466,
0.0036416512,
0.011716048,
0.00883934,
-0.016305706,
-0.004717148,
0.0052107647,
-0.028897842,
0.015155023,
0.008022093,
0.011369536,
0.014605832,
-0.011454529,
0.013546681,
-0.013056333,
-0.007897872,
-0.0151288705,
-0.01939163,
0.016488768,
-0.0038868252,
0.004164689,
-0.021418402,
-0.010611131,
-0.017482542,
0.026008058,
0.024033591,
0.005112695,
-0.00987234,
0.008401296,
0.002119938,
0.00017080456,
-0.0021706072,
-0.0067079607,
0.0052794134,
0.0048544453,
-0.0042791036,
-0.02900245,
0.007126391,
0.009270847,
0.02007158,
-0.025328109,
0.0021395518,
-0.0057697617,
-0.043569054,
-0.01435739,
-0.01644954,
0.0420784,
-0.024242805,
0.016828744,
-0.005622657,
0.017900972,
0.0069237137,
0.0093427645,
-0.048616372,
-0.026008058,
0.014854276,
0.0077932645,
0.012467915,
-0.0077867266,
-0.022569085,
-0.022438325,
0.026544172,
-0.023589008,
-0.0169072,
0.031016147,
-0.018894743,
0.028244045,
-0.028374804,
0.01699873,
0.029211665,
-0.006132619,
0.0057893754,
-0.023902832,
-0.0025236579,
0.0014399886,
-0.007812878,
-0.0016279554,
-0.022111427,
0.008466676,
0.0015895448,
0.01093803,
-0.029865462,
-0.02845326,
0.009401605,
-0.0053938283,
-0.004154882,
0.02154916,
0.011023023,
0.014488149,
-0.00047073408,
0.011094941,
-0.024177426,
0.022216033,
-0.0065608565,
0.015442694,
0.007113315,
-0.0026805692,
-0.011722586,
-0.0058351415,
0.013219782,
-0.025210425,
0.017508693,
-0.0084862895,
-0.011735663,
-0.016044186,
0.010231929,
0.012304466,
-0.004468705,
0.00016661617,
0.011722586,
-0.008309764,
-0.008054784,
-0.016214173,
-0.0010918416,
-0.010558827,
-0.02090844,
-0.00043804423,
-0.01893397,
-0.0012740876,
-0.019300098,
-0.036795713,
-0.011663744,
0.007852106,
0.18892129,
-0.004507933,
0.008165929,
0.042287614,
0.0090747075,
-0.0003025856,
0.019038578,
0.001298605,
0.0040796953,
0.030989993,
-0.0110557135,
0.011722586,
-0.029499337,
0.0036579962,
0.020372326,
0.01374282,
-0.038626347,
-0.012023333,
0.011127631,
-0.004478512,
-0.00241905,
0.006126081,
0.01635801,
-0.01829325,
0.021509932,
0.019208565,
-0.009153163,
-0.010277694,
0.013559757,
0.025118895,
0.0015887276,
-0.008826264,
-0.013330928,
0.005429787,
-0.0011997181,
0.0065150904,
0.0038312525,
-0.006250303,
0.013402846,
0.007329068,
0.008943948,
0.004919825,
-0.020398477,
-0.020333098,
-0.002507313,
0.02774716,
-0.009061631,
0.0035305056,
-0.009532365,
0.0066229673,
-0.02007158,
0.0040927716,
0.031120753,
0.017521769,
0.017364858,
0.018986275,
0.043412145,
0.0007612653,
0.017299477,
0.018960124,
-0.010310384,
-0.0067798784,
-0.014723516,
0.022359869,
-0.002832577,
0.028087134,
-0.020843059,
-0.018319402,
-0.024112046,
0.0067406506,
0.003087558,
-0.012082175,
-0.008250923,
0.006701423,
-0.0031594757,
-0.0035762715,
0.014618909,
0.018450161,
-0.01038884,
0.030571563,
0.0068256445,
0.0045177396,
-0.03229759,
-0.0086497385,
-0.022333717,
-0.0064693247,
0.013912807,
0.0003397703,
-0.031146906,
0.010506524,
0.005907059,
-0.008159391,
-0.018881667,
-0.002222911,
-0.0012896153,
-0.018149415,
-0.009610821,
-0.006577201,
-0.005923404,
-0.008146315,
-0.01600496,
0.06171847,
0.0072767646,
0.025602704,
-0.009976948,
-0.013952035,
-0.022804452,
0.02900245,
0.026596475,
-0.012814428,
0.009414682,
-0.05078698,
0.0047367616,
-0.012735972,
-0.015089643,
0.016867971,
0.023105199,
-0.00064725935,
0.0063581793,
-0.017613301,
-0.008800113,
-0.0010346343,
0.0490348,
0.00942122,
-0.011546061,
-0.01242215,
-0.018188642,
-0.0044588977,
0.010395378,
-0.000791912,
0.014200479,
-0.02497506,
-0.023170577,
0.018868592,
0.010931492,
-0.016593376,
0.0065870085,
0.012049485,
0.006616429,
0.019430857,
-0.0041254614,
-0.0068060304,
0.006341834,
-0.010421529,
0.020437704,
0.00007094723,
0.0027622937,
-0.00516173,
-0.012749048,
0.014069719,
-0.011990643,
-0.010146935,
-0.0046027335,
-0.009166239,
0.014514301,
-0.00696948,
-0.025301958,
-0.04291526,
-0.010702662,
-0.009565055,
-0.015887275,
0.016828744,
0.016214173,
-0.013304776,
-0.0037920247,
0.008185543,
-0.16475694,
0.016122643,
0.022974439,
-0.031931464,
0.0030663095,
0.00955198,
0.01906473,
-0.037344903,
0.011990643,
0.00877396,
0.030859236,
-0.026112666,
-0.018607073,
0.006636043,
-0.010205776,
-0.0003693955,
0.0078455685,
0.013847427,
0.023118274,
0.00942122,
0.028662475,
-0.012160631,
-0.0069498657,
-0.013729745,
-0.003429167,
0.00935584,
-0.008283612,
0.028740931,
-0.0011327039,
-0.013625137,
0.011258391,
0.020594617,
0.028087134,
0.0009251232,
0.0036874171,
0.0015135409,
-0.0019336056,
-0.027537944,
-0.007597125,
0.0075186696,
0.020424629,
0.03656035,
-0.0072767646,
0.027537944,
0.010009637,
0.0065445113,
0.007368296,
0.017508693,
0.015168099,
-0.01622725,
0.01910396,
-0.030493109,
0.01471044,
0.012892883,
0.007093701,
-0.009643511,
-0.0027835423,
0.011879498,
-0.0011327039,
-0.009218543,
0.0011090038,
-0.020934591,
0.0276164,
0.018567845,
-0.012637903,
-0.022229109,
-0.021758376,
-0.0032461039,
-0.018986275,
0.009375454,
-0.0055115116,
-0.023353642,
0.0001443462,
0.0062993374,
0.03352673,
0.020176185,
0.015377314,
0.0029600675,
0.013304776,
0.0089177955,
-0.0115395235,
0.001050162,
-0.03682187,
0.0029012258,
-0.018698605,
-0.00687141,
0.010768042,
0.022412173,
-0.00619473,
-0.01335708,
-0.00031566154,
-0.037057232,
-0.014658136,
-0.02842711,
0.0005753417,
0.004717148,
0.009042017,
0.01429201,
0.013795124,
-0.009434296,
0.0025138508,
-0.024752768,
-0.0019597576,
0.01816249,
0.034128223,
-0.021339945,
-0.03326521,
-0.0110557135,
0.010473833,
-0.006701423,
-0.008381682,
-0.0060835844,
-0.008571283,
0.009212005,
-0.017286401,
0.011552599,
0.004864252,
-0.024308186,
0.050368547,
-0.008270537,
0.061979987,
0.013795124,
-0.0011719317,
0.030989993,
-0.018947046,
-0.039306298,
-0.11726509,
-0.037161842,
0.0095062135,
0.03546197,
0.021026123,
0.01280789,
-0.008950486,
0.0047857966,
-0.0010256446,
0.03483432,
0.012441764,
-0.007943638,
-0.018437086,
0.009042017,
0.011977567,
-0.01712949,
0.017207947,
-0.02416435,
-0.036534194,
0.044013638,
0.0065445113,
-0.0050473157,
-0.0050636604,
-0.0004866704,
0.004834831,
0.0012397632,
-0.019156262,
0.020869212,
0.016684908,
-0.015625756,
0.020973818,
-0.0029698745,
0.01813634,
0.012958263,
-0.0062078056,
-0.015508073,
-0.015926503,
-0.00822477,
0.01284058,
-0.0040502744,
-0.009153163,
0.027302578,
0.0022147384,
-0.022752147,
-0.014945807,
0.02003235,
-0.0245174,
-0.02313135,
-0.0020659997,
-0.027014906,
-0.011336846,
0.007825954,
-0.03344827,
0.0071329293,
0.00011502747,
-0.0037854866,
0.01842401,
0.0017391009,
-0.0032068759,
-0.011977567,
-0.0041025784,
0.036115766,
-0.038861714,
0.013370155,
0.0007964069,
-0.013075947,
-0.023301337,
-0.000503424,
0.0011490488,
-0.0065445113,
0.0040175845,
0.015625756,
0.0022457938,
0.0027541213,
-0.020986894,
-0.015913427,
-0.0065183598,
0.00790441,
0.0025563475,
-0.013344004,
-0.00345205,
-0.027721008,
0.009852726,
-0.000010260277,
-0.014461997,
0.0022114695,
0.017822515,
0.007335606,
0.005916866,
-0.008277074,
-0.007407524,
0.019417781,
0.046628825,
-0.016188022,
-0.02090844,
0.0072309985,
-0.015351161,
-0.031565335,
0.00072448916,
-0.018502465,
-0.020176185,
-0.0060901223,
-0.04087541,
0.011081865,
0.012794814,
-0.0151811745,
-0.008819726,
-0.0031938,
0.004295449,
-0.0019025502,
0.005864562,
-0.00039963363,
-0.0070544733,
0.03645574,
-0.013834352,
-0.01435739,
-0.011532986,
-0.017783288,
0.022673693,
0.021640692,
0.015351161,
-0.0035206988,
0.018986275,
0.015063491,
0.004867521,
0.013965111,
-0.025864223,
-0.0056618853,
-0.0072767646,
-0.00487079,
-0.005730534,
-0.021470705,
-0.0050538536,
-0.043281384,
-0.012480991,
0.005586698,
-0.027119514,
-0.044249006,
-0.020620769,
0.017142566,
0.011559137,
0.01187296,
0.013886656,
-0.017979426,
-0.0018911088,
-0.006962942,
-0.007414062,
0.004269297,
0.023222882,
0.011369536,
0.005318641,
-0.0067668026,
0.038600195,
0.016109567,
0.009976948,
-0.018580921,
-0.008669353,
0.01677644,
-0.0068648723,
-0.009427758,
-0.009983486,
-0.018790135,
0.04061389,
-0.022542933,
0.010192701,
-0.012219473,
-0.0021951245,
-0.032219134,
-0.012069099,
-0.015795743,
-0.011513371,
-0.0002974778,
-0.016410314,
-0.0186463,
0.012467915,
-0.026400337,
0.02029387,
-0.0029339157,
-0.026308805,
0.018319402,
-0.0045569674,
0.04377827,
-0.014239706,
-0.0030009297,
-0.023654388,
0.015939578,
0.022346793,
0.0152334785,
-0.017626377,
0.0129844155,
0.00564554,
-0.00039452585,
-0.00022208679,
0.014945807,
0.025576552,
-0.0324545,
0.0276164,
0.0018698605,
-0.0043673664,
0.0028767083,
0.01032346,
0.007178695,
0.004717148,
0.000251712,
-0.012415611,
-0.030963842,
-0.017116414,
-0.02300059,
-0.013043257,
-0.03590655,
-0.024203578,
0.008015555,
0.014788896,
0.005377483,
-0.031382274,
0.0022882908,
0.0032673522,
-0.01322632,
-0.03368364,
0.016253402,
-0.018057883,
0.020241566,
0.0072833025,
0.021758376,
0.0023700155,
-0.0112191625,
0.0037626037,
0.0067144986,
0.0051486543,
0.016789516,
0.019666225,
-0.0058678314,
0.00010159398,
-0.009859264,
-0.029028602,
-0.027302578,
0.02651802,
0.0050407774,
-0.004184303,
-0.011578751,
-0.012749048,
0.06721037,
-0.0036612651,
-0.016671833,
0.0030532337,
-0.013245935,
0.036900323,
0.01671106,
0.009937719,
-0.013383232,
-0.0040764264,
0.0038574045,
-0.022124503,
0.016606452,
-0.04019546,
-0.02674031,
0.017534845,
0.0036285752,
-0.007891334,
0.009650049,
-0.034206677,
-0.0014694096,
-0.023301337,
-0.004655037,
0.00938853,
-0.024831222,
0.011879498,
0.02383745,
0.019888515,
0.003422629,
-0.027982526,
0.00048626176,
0.010271156,
-0.015508073,
0.013598985,
0.041607663,
-0.015377314,
0.0046125404,
-0.018868592,
0.001285529,
0.013245935,
-0.010813808,
0.0008924334,
-0.011506833,
0.0062404955,
-0.010303847,
-0.016384162,
-0.012114865,
-0.011748739,
-0.035566576
] |
The human cytomegalovirus UL111A region is active during both productive and latent phases of infection. During productive infection, the virus expresses ORF79, a protein with oncogenic properties, and cmvIL-10, a functional homolog of human IL-10. During latent infection of myeloid progenitor cells, an alternately spliced variant of cmvIL-10, termed latency-associated (LA) cmvIL-10 has previously been identified. To determine whether LAcmvIL-10 transcription occurs during productive infection, we performed 5' and 3' RACE to map UL111A | [
-0.016147058,
-0.017135654,
-0.020378247,
-0.04247006,
-0.013906242,
0.0019541236,
-0.023067227,
-0.009754142,
-0.030712364,
-0.017438823,
0.01803198,
0.015171644,
-0.014433493,
-0.007954897,
-0.009648691,
-0.015501176,
0.019191932,
-0.0070190276,
-0.0025769388,
-0.021920456,
-0.027865209,
0.003783025,
-0.012990144,
-0.025228955,
-0.016450228,
0.012660612,
-0.0032837845,
-0.03087054,
-0.0005029479,
0.005677833,
-0.0042740274,
0.00053137005,
0.0007809904,
0.012238812,
0.0013049459,
-0.00362485,
0.027891573,
-0.0034765606,
0.010386842,
0.0011171128,
0.020641873,
0.029552413,
-0.018308787,
-0.006040318,
0.0049891113,
0.0025670528,
0.004929796,
-0.008686459,
-0.030817814,
0.015000287,
0.013840335,
0.026784346,
-0.0070190276,
0.0020463925,
-0.012904465,
-0.011678607,
0.010900912,
0.0013074174,
0.00553943,
-0.03928019,
-0.006300648,
-0.015817527,
-0.019864177,
0.023699928,
0.015237551,
0.025584849,
-0.017254286,
0.009160984,
0.016740216,
-0.002194682,
0.03532581,
0.025848474,
-0.010142989,
0.0074671907,
0.016305234,
-0.012403578,
-0.022935413,
-0.017886987,
-0.00021563738,
0.009780504,
0.03200413,
-0.031555966,
-0.011685198,
0.029605137,
0.0020612215,
-0.0069992556,
0.027074333,
0.019191932,
-0.010788871,
-0.03337498,
0.017069748,
-0.00041397434,
0.029684225,
0.02072096,
-0.03036965,
-0.0012794072,
0.005625108,
0.035563074,
0.006986074,
0.005773397,
-0.008475558,
-0.0049989973,
-0.03158233,
-0.014288499,
-0.025268499,
0.0067059724,
0.011988367,
-0.007302425,
0.016292052,
-0.01667431,
-0.031055078,
0.018994214,
-0.012179496,
-0.043999087,
0.010630696,
0.004033469,
0.017017022,
-0.0137348855,
-0.0018997509,
0.006893805,
0.012159724,
0.04331366,
-0.009187346,
-0.012265174,
0.023383576,
0.014024873,
-0.007625366,
-0.01222563,
-0.030132389,
-0.0069465307,
0.024675341,
-0.0061984933,
0.0043135714,
0.007902172,
-0.019758727,
0.015092556,
-0.008001032,
0.003407359,
0.00041232668,
-0.02455671,
0.0012406872,
0.035457622,
-0.006933349,
0.012054274,
-0.005605336,
0.0054142075,
0.0072233374,
-0.0039016565,
0.0028982323,
-0.0070190276,
0.011665426,
-0.01875695,
0.035378534,
-0.011678607,
0.01398533,
0.013589892,
0.0028685743,
0.026586626,
-0.019850995,
-0.035035823,
-0.00912144,
0.0037303,
0.02185455,
0.02041779,
-0.0034600839,
0.021169124,
0.022711333,
0.0006994313,
0.0075067347,
-0.016344778,
-0.000006561673,
0.019152388,
-0.038990203,
0.034877647,
-0.0089896275,
0.01688521,
-0.017821081,
0.0075265067,
-0.0101825325,
-0.014169868,
-0.011138175,
0.026402088,
0.033111356,
-0.006847671,
-0.021894094,
0.0022787123,
0.039122015,
-0.009286206,
0.0089039495,
-0.013695342,
0.008383289,
0.0041290335,
0.016226146,
-0.0028323259,
-0.63776267,
-0.03450857,
0.012001548,
-0.01346467,
-0.01617342,
0.028972436,
0.008363517,
-0.016226146,
-0.02124821,
0.017834261,
-0.021406386,
0.014143505,
0.016002065,
-0.01617342,
-0.033111356,
-0.030686002,
-0.004827641,
0.010841597,
0.0022721218,
0.0015141986,
-0.021393204,
-0.019402834,
0.006986074,
0.009108259,
-0.017781537,
0.03015875,
0.046134453,
-0.028234284,
-0.007157431,
0.024069004,
-0.006333601,
0.02351539,
-0.020206891,
-0.013840335,
0.048217095,
-0.0039444957,
-0.018572412,
-0.004218007,
0.0075396877,
0.023146315,
-0.020510059,
-0.02630982,
-0.0067158584,
-0.0058887335,
-0.031213252,
0.010479111,
0.0072035654,
0.022355437,
0.0011854906,
-0.016924754,
0.009523469,
-0.018704226,
-0.0067092674,
-0.015685715,
0.001048735,
0.0034304261,
0.021775462,
-0.015527539,
0.011012953,
0.0026659123,
-0.023080409,
0.003667689,
0.017689267,
-0.0037204141,
-0.009642101,
-0.0059612305,
-0.013629436,
-0.00456072,
0.020022353,
0.008007623,
0.0062578092,
0.03387587,
0.020061897,
0.010439567,
0.001043792,
0.027917935,
-0.0022095107,
-0.015277094,
0.010459339,
0.0050912662,
0.0007360917,
-0.012258583,
-0.03867385,
-0.00476503,
-0.008607371,
-0.019771907,
-0.02797066,
0.022539975,
-0.0073090154,
0.00037134116,
0.0028273829,
0.014802569,
-0.008033985,
-0.046345353,
-0.036222138,
0.023607658,
0.0071244775,
0.0125353895,
-0.013695342,
-0.00974096,
0.0049957023,
-0.02134048,
0.01430168,
0.0034666746,
0.0261121,
0.009464153,
-0.03181959,
0.026336182,
0.034350395,
-0.024069004,
-0.008686459,
-0.0063896216,
-0.0040169926,
-0.013774429,
0.0045673107,
-0.023660384,
0.017056566,
0.01221904,
-0.003397473,
-0.02538713,
0.010426386,
0.003025102,
0.00869964,
-0.0051143337,
0.010235257,
0.020259615,
0.03118689,
-0.012449712,
0.0010174294,
-0.015211188,
0.015487995,
-0.024925785,
0.042232797,
-0.029394237,
0.034983095,
0.014024873,
0.032030493,
0.009899136,
-0.01295719,
-0.020325521,
-0.039728355,
-0.020351885,
-0.015580264,
0.00025394544,
0.0025983583,
-0.017148836,
-0.010110036,
-0.0015899909,
-0.0037006421,
0.00086749246,
0.008337155,
-0.022091812,
0.006722449,
0.012812196,
0.006079862,
-0.016766578,
-0.00049306196,
-0.02402946,
0.006761993,
-0.014459856,
-0.0089171305,
0.018256063,
0.0010734499,
0.015171644,
0.017768355,
0.016318414,
0.00983982,
0.009371884,
-0.006030432,
-0.02818156,
0.011968595,
-0.004712305,
-0.0035490575,
0.0025077371,
0.020786867,
-0.0056613563,
-0.0021683192,
-0.0020365065,
0.000826301,
-0.0036413264,
0.014288499,
0.021024128,
0.009905726,
-0.015514357,
0.022394981,
0.014987106,
0.020747323,
0.017491547,
0.03324317,
0.024213998,
-0.014064417,
0.018638318,
-0.016621584,
0.017320191,
0.02538713,
-0.0021337185,
0.0021666717,
0.010492293,
0.005348301,
0.015988883,
-0.007697863,
-0.033295892,
-0.017425641,
-0.0033332142,
0.014578487,
-0.039122015,
-0.005997479,
-0.046187177,
0.019284202,
-0.0022243396,
0.008066938,
0.0028636314,
-0.013761248,
0.0088907685,
-0.0065543875,
0.009035762,
-0.006415984,
0.0048111645,
0.0031470289,
-0.0151321,
-0.022394981,
0.0018140726,
0.010742737,
-0.01430168,
0.022223625,
0.015922977,
-0.021907274,
0.016766578,
0.0072233374,
-0.002870222,
-0.017425641,
0.0046661706,
0.026797526,
0.021116398,
-0.0015603331,
0.0068542617,
0.02538713,
-0.005242851,
0.02434581,
0.0012069102,
-0.014763025,
0.0011640711,
-0.0019640096,
-0.00015436506,
0.02351539,
-0.022118175,
0.019099664,
0.010907503,
-0.017030204,
0.01927102,
-0.021327298,
-0.0006421751,
-0.006794946,
-0.0055262484,
-0.009174165,
-0.0037500719,
-0.009450972,
-0.0018470258,
0.04547539,
0.028155198,
-0.0007570993,
-0.019771907,
0.0017893577,
0.006508253,
-0.004603559,
0.009477335,
-0.0012629307,
-0.018295607,
-0.00357542,
-0.0077637695,
-0.013049459,
0.0034007682,
0.010966819,
-0.041705545,
-0.008857815,
0.024596253,
-0.016700672,
0.005031951,
0.0149080185,
0.021274574,
-0.025848474,
-0.03355952,
0.013537167,
0.015843889,
-0.011151357,
-0.015698895,
-0.016555678,
0.011164538,
-0.0016402446,
0.008343745,
0.005407617,
0.002087584,
-0.0060567944,
0.009523469,
-0.0045771967,
0.006663133,
0.02860336,
-0.010479111,
0.0011418277,
0.0051044477,
-0.025677118,
0.011685198,
-0.008356927,
0.0016987365,
0.020681417,
0.014670756,
0.00963551,
-0.0018981032,
-0.0033529862,
-0.009549832,
-0.0051538777,
-0.0021139465,
-0.0043959543,
-0.004023583,
0.019640096,
0.003931314,
-0.0005194245,
-0.0014878361,
0.01585707,
0.022698151,
-0.014855294,
-0.017570635,
-0.0073683313,
-0.024741247,
0.013095594,
0.024741247,
-0.00037443053,
0.025334405,
-0.0029855582,
0.009892545,
-0.02031234,
-0.038041152,
0.021287754,
-0.017886987,
-0.012990144,
-0.001077569,
-0.007638547,
0.0012027911,
0.02528168,
0.013313085,
0.028919712,
-0.026573446,
0.0013889766,
0.023172677,
0.017623361,
-0.013840335,
0.0013584949,
0.032294117,
0.0012365681,
-0.017372917,
0.015013469,
0.016951116,
-0.007954897,
-0.029868763,
-0.014117142,
0.011408391,
-0.006577455,
0.005120924,
0.0112765785,
-0.009543241,
0.021327298,
0.008640324,
0.0030778272,
0.0149475625,
0.031898677,
0.03334862,
0.011876326,
0.008383289,
0.00011276166,
-0.002057926,
-0.009892545,
0.01720156,
-0.0038390455,
-0.024490803,
0.043050036,
-0.016740216,
-0.004234484,
-0.009569604,
0.021103216,
0.01046593,
-0.012192677,
0.012627658,
-0.0071310685,
-0.005934868,
-0.023858102,
-0.017412461,
0.01637114,
-0.011737923,
-0.011803829,
-0.021525018,
-0.009147803,
-0.01015617,
-0.027047971,
-0.0077439975,
0.012719927,
-0.019442376,
-0.024978511,
0.013497623,
0.01284515,
0.02093186,
0.0030728842,
-0.028102472,
-0.014183049,
0.023489026,
-0.033216804,
-0.017913349,
0.005430684,
-0.03957018,
0.008383289,
0.0062676948,
0.010222076,
-0.012304718,
-0.011876326,
-0.022394981,
-0.01409078,
-0.012410168,
0.020246435,
-0.0011615996,
-0.0010215486,
0.01564617,
0.020496879,
0.031898677,
-0.007585822,
-0.01565935,
-0.003792911,
-0.036433037,
-0.009622329,
-0.021617286,
-0.015066194,
-0.0074474188,
-0.0009119793,
0.022948595,
-0.04310276,
-0.017003842,
0.011131585,
-0.0044058403,
-0.012087227,
0.009450972,
0.03514127,
0.023673564,
0.0074210563,
-0.005213193,
0.03118689,
-0.0039741537,
-0.024807155,
-0.015198007,
0.022684969,
-0.010525246,
0.001338723,
0.039174743,
0.0100836735,
-0.0031635053,
0.0034337214,
-0.003020159,
-0.014024873,
0.038700216,
0.009688235,
-0.027074333,
-0.023489026,
-0.016107515,
0.020351885,
0.013629436,
0.004890252,
-0.012258583,
-0.007243109,
0.013082413,
-0.0049265004,
-0.0032738985,
0.011045906,
-0.027258871,
0.010195714,
0.042127345,
0.009642101,
-0.004218007,
0.010604333,
-0.0020859363,
-0.017043386,
-0.0018058344,
-0.016015247,
0.01658204,
-0.000009351752,
-0.0047090095,
0.032715917,
0.00259012,
0.04133647,
-0.008060348,
-0.007315606,
0.0058986195,
0.021010948,
0.0032936705,
-0.0064588236,
-0.0037533673,
-0.007157431,
0.008192161,
0.022236805,
0.016806122,
0.008330564,
-0.015329819,
0.015685715,
0.031476878,
-0.009266434,
-0.011480888,
-0.008475558,
-0.019903721,
-0.014222593,
-0.009787095,
-0.030738726,
0.008778728,
-0.042918224,
-0.0034271309,
0.040598318,
-0.00094081333,
0.018915126,
-0.004115852,
0.017425641,
-0.016740216,
0.033533156,
-0.014644394,
-0.00035651223,
-0.0003130552,
0.00953006,
-0.010255029,
0.01688521,
0.023594478,
0.0113227125,
0.005677833,
0.025228955,
-0.0012785834,
-0.0010594447,
0.012179496,
-0.026665714,
-0.014222593,
-0.018638318,
-0.029736951,
-0.024741247,
-0.020048715,
-0.002865279,
-0.04152101,
-0.00023973439,
-0.006640066,
0.0013856812,
0.015356182,
-0.0060337274,
-0.02383174,
0.048717983,
0.022974957,
0.025347587,
-0.02549258,
0.022935413,
-0.003657803,
0.00077769504,
-0.02445126,
-0.022434525,
-0.006175426,
0.0061688353,
0.024293086,
0.015092556,
-0.002947662,
-0.0040664226,
0.0313187,
0.00069737167,
0.015422088,
-0.04431544,
0.014433493,
0.01171156,
0.011639063,
-0.003960972,
-0.020061897,
-0.01729383,
0.021630468,
-0.0038588175,
0.008660096,
-0.0068344898,
0.00073238445,
-0.015277094,
0.008686459,
-0.01222563,
0.019020576,
-0.017465185,
-0.025466219,
-0.0009861239,
-0.03139779,
0.011118403,
-0.012087227,
-0.005918391,
0.022539975,
0.015830709,
-0.009352113,
-0.00085595885,
-0.012462893,
0.00021017951,
0.008567827,
-0.022948595,
0.03780389,
-0.0149080185,
0.004059832,
0.004643103,
-0.00092021754,
0.011434753,
0.005031951,
0.013398763,
-0.006755402,
-0.023805378,
-0.0070519806,
0.027311597,
0.014433493,
-0.020562785,
0.0076912725,
-0.010617515,
0.0014120438,
-0.04175827,
-0.032768644,
-0.0017910054,
-0.051960576,
0.0056316988,
-0.0011945528,
0.015290276,
0.012799015,
0.025624393,
-0.0028438594,
-0.008001032,
0.01854605,
-0.010749328,
0.010953637,
0.008765546,
-0.011230444,
-0.009450972,
-0.0017102701,
-0.008304201,
-0.011447935,
0.019231476,
-0.014183049,
-0.011830192,
-0.008983037,
-0.00022881865,
0.011382028,
-0.009688235,
-0.006412689,
0.018717406,
-0.009338931,
0.0040861946,
0.00496934,
-0.0037797298,
0.024662161,
-0.026757983,
-0.0148816565,
0.020048715,
-0.0011871384,
-0.00026609693,
-0.009497107,
0.0013032983,
0.016951116,
-0.027865209,
-0.015092556,
-0.011612701,
0.0051769447,
0.01015617,
0.00061251724,
0.0014161629,
0.0013090651,
-0.0055361344,
0.0046365126,
-0.002450069,
-0.0048111645,
-0.015698895,
-0.008001032,
-0.006742221,
0.029446961,
-0.02443808,
0.006814718,
0.011190901,
-0.03812024,
-0.01729383,
-0.013616255,
-0.017662905,
0.028234284,
-0.009233481,
-0.014723481,
-0.040044706,
-0.021511836,
-0.045317214,
-0.0036610984,
0.012990144,
0.015369363,
0.008693049,
0.035457622,
-0.00973437,
-0.0046266266,
-0.013201044,
0.0137217045,
-0.0033496907,
0.003397473,
0.035378534,
-0.0019722478,
0.021116398,
0.0032294118,
0.0019409424,
0.0022638836,
0.006986074,
0.016120696,
-0.01067683,
0.030527826,
-0.028260648,
0.00010915741,
-0.009233481,
0.02661299,
-0.022131355,
0.013576711,
0.008468968,
-0.024793973,
-0.015553901,
0.013405354,
-0.0025472809,
0.010452749,
-0.0051472867,
-0.020127803,
-0.0010330823,
0.008383289,
0.008501921,
-0.033084992,
0.008686459,
-0.006732335,
0.031160528,
0.017359735,
0.013042869,
0.00029534288,
0.004867185,
-0.010927275,
-0.004531062,
0.005256032,
-0.015527539,
-0.0015430327,
0.025044417,
0.0013584949,
-0.021221848,
0.02134048,
-0.0046760566,
-0.022566339,
-0.024411716,
0.026138462,
0.014051236,
-0.043076396,
-0.006880624,
0.014077599,
-0.010426386,
-0.012041092,
-0.0037995018,
-0.0047156,
-0.008897359,
0.017003842,
0.006122701,
0.0048012785,
-0.012410168,
0.009398247,
-0.032083217,
0.0033562814,
-0.010927275,
-0.011981777,
-0.0057997596,
0.007065162,
0.18611957,
-0.010999772,
-0.013115366,
0.0077571785,
-0.015237551,
0.005832713,
0.024069004,
0.00020945865,
0.018822856,
0.0032145828,
0.019903721,
-0.014038055,
0.013853517,
-0.0017069748,
0.0028899938,
-0.008231704,
-0.0015010174,
-0.019850995,
-0.008732593,
-0.018585594,
0.009978223,
-0.01056479,
-0.0016023484,
-0.012733109,
0.029367875,
-0.004652989,
-0.04030833,
0.025268499,
0.0025439856,
0.015791165,
-0.04175827,
0.013181272,
-0.0037665486,
0.025123505,
0.007335378,
0.024938967,
-0.005354892,
-0.013121957,
-0.014341224,
-0.0010643877,
0.0089896275,
0.0035523528,
-0.03606396,
-0.0076121846,
-0.020009171,
0.032452293,
-0.0051868306,
-0.014473037,
-0.0022424639,
-0.009589376,
-0.01875695,
0.016489772,
-0.005213193,
0.008818272,
0.004962749,
-0.006992665,
0.023462664,
0.01617342,
-0.023871284,
0.02041779,
-0.015079375,
0.017807899,
-0.02994785,
0.0030778272,
0.003614964,
0.032452293,
0.0035523528,
-0.0026510833,
0.019402834,
-0.041151933,
0.016937936,
-0.012278355,
-0.007717635,
-0.00787581,
0.001990372,
-0.0077439975,
0.010024358,
0.016621584,
0.02839246,
0.008099892,
0.010347298,
-0.004316867,
-0.01409078,
0.027311597,
0.00032891394,
-0.028207922,
0.025940744,
0.022302713,
0.0038917707,
-0.00033797606,
0.012970372,
-0.032795005,
-0.005977707,
0.015698895,
0.0057140817,
-0.0038884752,
0.0060732714,
-0.0059019146,
0.018097887,
-0.016647946,
-0.023871284,
0.064166434,
0.05317325,
0.0007838738,
-0.0014565305,
-0.00094987545,
-0.0048342315,
-0.010861368,
0.0043333434,
-0.03893748,
0.020496879,
-0.013800792,
-0.004939682,
0.0022869508,
0.013761248,
0.0030185115,
0.0055789733,
-0.024886241,
0.016595222,
0.004837527,
-0.0046991236,
-0.020404609,
-0.0024055822,
0.011790648,
-0.00932575,
-0.022711333,
-0.035826698,
0.00050047645,
-0.01596252,
-0.021577742,
0.013800792,
-0.01709611,
-0.002397344,
0.010195714,
0.006422575,
-0.009081896,
0.0023660383,
0.0034798558,
-0.024622617,
-0.0044717467,
-0.011592929,
-0.028682448,
0.015593445,
-0.018664682,
-0.004939682,
-0.0054537514,
0.022671789,
0.025822112,
-0.007605594,
-0.017465185,
-0.008429424,
-0.0296315,
0.01502665,
-0.007262881,
0.016450228,
-0.02692934,
-0.029394237,
-0.02383174,
-0.014749844,
-0.00063311297,
-0.021116398,
0.016107515,
0.018124249,
-0.011830192,
-0.008660096,
-0.014763025,
-0.16597858,
-0.003010273,
-0.015329819,
-0.017491547,
0.03648576,
0.027627947,
0.0026082443,
-0.0045969686,
-0.0051571727,
0.024675341,
0.043023672,
0.01998281,
-0.047478944,
-0.008429424,
-0.014143505,
-0.016199784,
-0.031345066,
0.032478657,
0.04091467,
-0.0017168607,
0.034244947,
-0.040044706,
0.014130324,
-0.008403061,
-0.0032491835,
0.015975703,
-0.010492293,
0.005397731,
-0.018888762,
-0.029341511,
-0.011685198,
0.0031585624,
0.03108144,
-0.030554188,
0.020259615,
-0.011823601,
0.006953121,
-0.006069976,
-0.0033068517,
0.01647659,
0.0151321,
0.0101298075,
0.001802539,
0.013326266,
-0.011902689,
0.037777524,
0.007341969,
-0.01627887,
-0.0006504134,
0.0012670498,
0.02227635,
-0.026850251,
0.02321222,
0.011790648,
0.019205114,
0.008719412,
0.016502952,
0.018717406,
0.02061551,
0.0144994,
-0.017531091,
-0.009352113,
0.023594478,
0.0045771967,
0.030554188,
-0.06316466,
-0.007862628,
0.03324317,
-0.023172677,
0.002860336,
-0.009292797,
-0.0022820078,
0.01637114,
-0.021617286,
0.010400024,
0.02570348,
-0.016397502,
0.042628236,
-0.00059150957,
-0.0045673107,
-0.01998281,
0.02889335,
-0.041072845,
-0.007282653,
-0.02828701,
-0.00601066,
-0.0036808702,
0.025228955,
0.0062083793,
-0.0018107772,
-0.019178752,
-0.0033035565,
-0.022948595,
-0.018084705,
0.036828473,
0.04070377,
0.012410168,
-0.011573157,
-0.019152388,
-0.004942977,
0.018321969,
-0.009760732,
-0.016647946,
0.004402545,
0.04247006,
-0.023779016,
-0.030000575,
0.00663018,
0.028260648,
-0.008251476,
-0.010419795,
0.009628919,
0.012878103,
0.032478657,
0.006600522,
0.0077571785,
-0.018295607,
-0.0029740245,
0.004287209,
-0.008409652,
0.05520317,
-0.00026589097,
-0.019850995,
0.0064917766,
-0.030817814,
-0.007645138,
-0.120529555,
-0.026771164,
0.0011442992,
0.0013832097,
-0.026283456,
0.030817814,
0.0012621068,
0.016463408,
-0.024358992,
0.015830709,
-0.033717696,
-0.0147103,
-0.0063764406,
0.0023347328,
0.013075822,
-0.011480888,
0.022236805,
-0.007941716,
-0.034060407,
0.022829963,
0.005720672,
0.004339934,
-0.0065247295,
-0.027469771,
0.01409078,
-0.0043333434,
-0.030554188,
0.008238295,
0.015527539,
0.0137217045,
0.037487537,
-0.024701703,
0.022381801,
0.009365294,
-0.021946818,
-0.008976446,
-0.035194,
-0.01087455,
0.03893748,
-0.031028714,
0.0050055883,
0.007262881,
0.0070519806,
-0.0037171189,
0.03780389,
-0.0125090275,
-0.00043086283,
0.021788644,
0.0038357503,
-0.032505017,
-0.029710587,
-0.025624393,
-0.04423635,
-0.017017022,
0.00012501613,
-0.0354049,
0.0075594597,
0.020496879,
-0.034350395,
-0.018994214,
-0.005875552,
0.0017712335,
-0.0000047466738,
0.015395726,
0.029499687,
-0.008119664,
-0.0024583072,
-0.025729844,
0.022790419,
-0.027548859,
-0.0064687096,
-0.008653505,
-0.015843889,
-0.025743024,
-0.0021205372,
-0.0054339794,
-0.0018832743,
-0.022447707,
0.013003325,
-0.012179496,
-0.016450228,
-0.017649723,
0.031055078,
0.007157431,
0.03295318,
0.006333601,
0.0015422088,
-0.016133877,
-0.0017959484,
-0.0020760503,
0.009213709,
0.05583587,
0.0010561495,
-0.017491547,
-0.024886241,
0.021314118,
-0.019864177,
-0.019310564,
0.013550348,
0.019112844,
-0.017280648,
-0.007908763,
-0.06400826,
0.011968595,
-0.00094987545,
0.006465414,
-0.012041092,
-0.009068715,
-0.004992407,
-0.01057138,
-0.0055855643,
0.02889335,
-0.012469484,
0.031977765,
-0.008119664,
0.03450857,
-0.024991693,
0.005295576,
0.0370921,
-0.019126026,
0.013616255,
0.017017022,
0.0026411975,
-0.0026560263,
-0.017359735,
0.02712706,
-0.008271248,
0.009589376,
-0.016502952,
0.027759759,
-0.007961488,
-0.0021683192,
0.0040565366,
-0.014683938,
0.0020414495,
0.018875582,
-0.0027631242,
-0.017952893,
0.010037539,
0.026098918,
0.013214226,
0.04175827,
-0.017913349,
-0.038568404,
0.015105738,
0.017372917,
0.0050681992,
0.01481575,
-0.034824923,
0.0031585624,
0.0030218067,
0.0016921458,
0.039201103,
0.00076492573,
-0.002092527,
-0.056415845,
0.006972893,
0.005345006,
-0.006933349,
-0.027364321,
-0.0052362606,
0.015870253,
0.02621755,
0.0015282037,
0.015422088,
0.018928306,
0.000932575,
-0.004593673,
-0.0037995018,
0.0010479111,
-0.014802569,
-0.008020804,
-0.009675054,
0.00715084,
-0.010755918,
0.009721188,
0.006142473,
0.013174682,
0.013135138,
0.008376699,
-0.009820048,
-0.005572383,
0.0065741595,
0.0074342377,
-0.003010273,
0.0038522268,
0.015619808,
0.016845666,
-0.002687332,
0.037988428,
-0.015817527,
0.0073485593,
0.0014952506,
0.022500431,
0.017254286,
0.017570635,
0.004797983,
0.020220071,
-0.000083824656,
0.011302941,
0.0068344898,
0.022236805,
-0.009233481,
-0.0008567827,
0.002479727,
-0.022816783,
0.0014622974,
0.018190155,
-0.037487537,
-0.037988428,
-0.0070915245,
0.0059711165,
0.014143505,
-0.00064670615,
0.013009916,
0.0030168637,
-0.020220071,
-0.023344032,
0.012172905,
-0.008271248,
-0.011447935,
0.034666747,
0.012990144,
0.023357214,
-0.009055534,
-0.008884178,
0.009971633,
0.014538943,
0.022144537,
-0.0068674427,
0.02860336,
-0.020404609,
0.0018816267,
-0.0033496907,
-0.014618031,
-0.026507538,
-0.022025906,
0.009767323,
0.010400024,
0.008060348,
0.007711044,
0.09358703,
0.01729383,
-0.02952605,
-0.005213193,
-0.02041779,
0.0040169926,
0.01181042,
-0.0058162366,
-0.0015899909,
-0.031555966,
0.019666458,
-0.026402088,
0.018677862,
-0.035800334,
-0.032584105,
0.0072562904,
0.023739472,
0.011124994,
-0.0053285295,
-0.010287983,
0.03181959,
-0.021630468,
0.0033694627,
0.012311309,
-0.030712364,
0.0010009529,
0.025439855,
-0.006893805,
0.0011368847,
-0.04186372,
0.008548055,
-0.007322197,
-0.020035533,
-0.009846411,
-0.0046661706,
-0.0354049,
0.002807611,
-0.022777239,
0.026705258,
0.020285979,
0.0016105867,
-0.0017036794,
0.0031733913,
-0.010274801,
0.009642101,
-0.016898392,
-0.013293313,
-0.006205084,
-0.015382545
] |
Several members of the Kruppel-like factor (KLF) family of transcription factors play important roles in differentiation, survival, and trafficking of blood and immune cell types. We demonstrate in this study that hematopoietic cells from KLF4(-/-) fetal livers (FL) contained normal numbers of functional hematopoietic progenitor cells, were radioprotective, and performed as well as KLF4(+/+) cells in competitive repopulation assays. However, hematopoietic "KLF4(-/-) chimeras" generated by transplantation of KLF4(-/-) fetal livers cells into | [
-0.005011068,
-0.0056242514,
0.0014511999,
-0.03962525,
-0.02644863,
0.0054777684,
-0.028070157,
0.009231811,
-0.019458342,
-0.022278985,
0.004455797,
-0.00566513,
-0.007187868,
0.0047760145,
-0.020180536,
-0.003064212,
0.013728487,
-0.027606864,
0.0026264675,
0.0018736148,
-0.012474868,
0.013803432,
-0.012842778,
-0.030550143,
-0.022142721,
0.00020843965,
0.027824884,
-0.03444726,
-0.005695789,
-0.018572634,
0.012481682,
0.008196213,
-0.002476578,
0.014907162,
-0.001601089,
-0.01821835,
-0.007705667,
-0.01990801,
0.025208637,
0.011500589,
0.023995897,
0.022851288,
0.002202349,
-0.0050383206,
-0.003719977,
-0.0026656429,
0.004919091,
-0.005290407,
-0.009797303,
0.02736159,
0.008509618,
0.0014750459,
0.0064179827,
0.000706438,
-0.012406738,
-0.011418831,
0.016882973,
-0.009906312,
-0.017128246,
-0.022428874,
-0.011616413,
-0.010764769,
-0.009368074,
0.0028427849,
0.0052563413,
0.01847725,
-0.007869182,
0.026680276,
0.0045443675,
0.004946343,
0.022115469,
0.01917219,
-0.02064383,
0.0050723865,
0.0073105046,
-0.012379484,
0.00039835606,
0.004220743,
-0.015465839,
-0.0108601535,
0.025317647,
-0.014879908,
-0.015751991,
0.012222782,
0.026939176,
-0.011555094,
0.004748762,
0.032485075,
0.02155679,
-0.0008409976,
-0.0072083073,
0.0012178497,
0.042950068,
0.031858265,
-0.00349855,
-0.012420364,
0.01564298,
0.023219198,
0.009170493,
-0.038589653,
-0.0146482615,
-0.009102362,
-0.0071265497,
-0.01182762,
-0.020207789,
0.011609599,
-0.006486114,
0.009095549,
0.016201658,
-0.011732236,
-0.03758131,
0.038017347,
0.013128931,
-0.04349512,
0.013878376,
-0.031204205,
-0.00095639523,
-0.0033691002,
-0.021883821,
0.008148521,
0.024922485,
0.023668867,
0.0009580985,
-0.03382045,
0.020207789,
0.03760856,
0.015956385,
-0.0187634,
-0.030141354,
-0.0048373328,
0.012529374,
-0.004169645,
0.016910225,
-0.0012221079,
-0.014661888,
0.008605002,
-0.019035928,
0.009940378,
-0.012686076,
-0.0030386627,
0.012311353,
0.024077654,
-0.008271158,
-0.011630039,
-0.0059001837,
0.014144089,
0.027429722,
-0.00015712816,
-0.006199962,
-0.01774143,
0.004925904,
-0.014212221,
0.03515583,
-0.023191946,
0.011745862,
0.00063745485,
0.0028887736,
0.038562402,
0.0004641455,
-0.026530387,
-0.017400773,
-0.024990616,
0.021393275,
0.01626979,
0.01074433,
0.014457494,
0.017755056,
0.022428874,
0.011405204,
-0.02614885,
0.0021205915,
0.0047215093,
-0.03463803,
0.0047998605,
-0.004207117,
0.00021227205,
-0.00953159,
0.005770734,
-0.02225173,
-0.02107987,
0.0019775154,
0.012454429,
0.020398555,
0.0029892675,
-0.012672449,
-0.0040674475,
0.013953321,
-0.028369935,
-0.007617096,
-0.008891154,
0.007419515,
0.01939021,
-0.0040299753,
-0.024690837,
-0.6252832,
-0.024540948,
0.025263142,
-0.015493092,
0.003391243,
0.028179169,
-0.0036075602,
-0.023886887,
-0.024690837,
0.017278137,
0.0045818402,
0.022973925,
-0.0018242196,
-0.012318166,
-0.012672449,
-0.043985665,
-0.0229603,
-0.019403838,
0.021447781,
-0.012004762,
-0.0054777684,
-0.010001697,
-0.0065780915,
0.02225173,
-0.013224315,
0.035101324,
0.02578094,
-0.009865434,
-0.010117521,
0.021802064,
-0.025290394,
0.02266052,
-0.001169306,
0.025086,
0.055404495,
-0.0015840562,
-0.025644679,
0.005927436,
0.027933894,
0.042405013,
-0.015956385,
0.0041219527,
0.03158574,
0.0073173176,
-0.007228747,
0.009817742,
0.011003229,
0.02673478,
0.0029296523,
0.019403838,
-0.007957754,
0.011275755,
-0.028124662,
0.006234028,
0.0056004054,
0.0043297536,
0.014062331,
-0.019894384,
-0.019226694,
-0.004367226,
-0.018449998,
0.007753359,
-0.025086,
-0.0026213576,
0.009354448,
0.015711112,
-0.004220743,
-0.0056685368,
0.013483214,
-0.025045121,
0.012672449,
0.025944456,
-0.0048271134,
0.0050485404,
0.005011068,
0.03243057,
0.0053585386,
0.0063532577,
0.01667858,
0.01752341,
-0.0023403154,
-0.019717243,
-0.00782149,
0.013176623,
0.025903577,
-0.00470107,
-0.026489507,
0.015738364,
-0.008264345,
0.004448984,
0.007617096,
0.022319863,
-0.01843637,
-0.040715355,
-0.03147673,
0.017973077,
-0.0031936618,
0.003600747,
-0.006663256,
-0.04297732,
-0.0021035585,
-0.016351549,
0.014048705,
0.0033605837,
-0.0024442158,
0.0100698285,
-0.024527323,
-0.01384431,
0.027116317,
-0.043004572,
-0.007664788,
0.0069698473,
-0.0020797125,
-0.001481859,
-0.0007366713,
-0.019867131,
0.024295675,
0.009470272,
0.0015338092,
-0.026325993,
0.05289726,
0.010757956,
0.004915684,
0.0013839201,
0.0068199583,
0.019185817,
0.006496334,
-0.006111391,
0.006533806,
-0.0072559994,
0.013878376,
0.006216995,
0.030740911,
-0.03294837,
0.024704464,
-0.0033725067,
0.026530387,
-0.0018225163,
0.03158574,
-0.023532603,
-0.019512847,
-0.02450007,
-0.0041015134,
-0.0123249795,
-0.015084303,
-0.007092484,
0.008141709,
-0.001011752,
0.017714176,
0.0040265685,
-0.019049553,
-0.0017015829,
-0.012365858,
0.010178839,
0.015479466,
-0.02137965,
0.0037029444,
-0.006469081,
0.0072696256,
-0.015465839,
-0.015288698,
0.01748253,
-0.00842786,
0.021638548,
0.014130463,
-0.006710948,
0.009797303,
-0.00615227,
0.013128931,
-0.02266052,
-0.0030301462,
-0.0147300195,
-0.013769366,
0.0008665469,
-0.021515911,
-0.004193491,
0.012529374,
0.00006605557,
-0.0074058888,
0.006942595,
-0.007521712,
-0.027238954,
-0.01748253,
-0.009088735,
0.021025365,
0.02883323,
0.020630203,
0.029460039,
0.0060466663,
0.042405013,
-0.013428709,
0.0060602925,
-0.029242018,
0.015329576,
0.004408105,
-0.0245682,
0.0008771924,
0.0060602925,
-0.007283252,
0.018627139,
0.011357512,
-0.027865764,
0.012876844,
-0.03125871,
0.025317647,
-0.021570418,
0.0005548455,
0.0050655734,
0.002873444,
-0.0041492055,
-0.0062987525,
0.014225847,
-0.019199442,
0.00180889,
0.013748927,
-0.009190933,
0.0060057873,
-0.020221414,
-0.0021495472,
-0.026598519,
-0.0075489646,
-0.0045375545,
0.025126878,
0.0062715,
0.0055016144,
-0.00590359,
-0.0014060629,
-0.0009069999,
0.013162997,
-0.0023181725,
-0.012386298,
-0.012399924,
0.009790489,
-0.0023965237,
-0.00013296278,
0.022088217,
0.011125865,
-0.014675515,
0.016596822,
-0.021883821,
0.014675515,
-0.0014469416,
0.016951105,
0.015261445,
-0.009933566,
-0.022946673,
0.021570418,
-0.009838182,
-0.023355462,
0.005218869,
-0.009695105,
0.029187514,
-0.006990287,
0.0014120243,
0.004006129,
-0.005154144,
-0.0060194135,
0.0052393083,
0.025998961,
0.01817747,
0.026257861,
-0.012229595,
-0.009088735,
-0.026257861,
0.005474362,
0.019471968,
-0.011187184,
-0.009572469,
-0.0112553155,
-0.0055697463,
-0.045648072,
-0.004220743,
0.022020085,
-0.024636332,
0.017087368,
0.016624074,
0.013530906,
0.0009035934,
0.018368239,
-0.0009947192,
0.011970696,
-0.030659152,
0.020466687,
0.037990097,
-0.014212221,
-0.016624074,
-0.03243057,
-0.013210688,
0.007685228,
0.009122801,
0.008482366,
-0.0013762553,
0.002796796,
0.013415082,
0.006247654,
0.0024084467,
0.030441131,
-0.013053986,
0.025740063,
-0.011616413,
-0.016828468,
-0.006445235,
-0.010410486,
-0.00723556,
0.050962325,
-0.003972064,
0.014280352,
0.004990629,
0.00951115,
0.001773121,
0.0042854683,
-0.015806496,
0.001868505,
-0.0075421515,
0.0045682136,
-0.011275755,
-0.003961844,
0.016651327,
0.01785044,
-0.0047453553,
-0.015983637,
-0.023232825,
-0.016079022,
0.0025481163,
0.021842944,
0.029105756,
0.0013251567,
0.027634116,
-0.014007826,
-0.004135579,
0.0022534477,
-0.008986538,
0.02306931,
-0.006918749,
0.008332476,
-0.0047930474,
-0.0019741089,
0.0048475526,
-0.01997614,
0.0060875453,
-0.0071061105,
-0.012011575,
-0.011800367,
0.010328728,
0.0066666626,
0.0033162984,
0.032594085,
0.032212548,
0.013530906,
0.019185817,
0.0044421707,
0.034147482,
-0.005958095,
0.008863902,
-0.007678414,
0.012808712,
0.008857088,
0.003754043,
0.0056004054,
-0.041778207,
0.0028632241,
0.008025885,
-0.008012258,
-0.007092484,
0.02060295,
0.032021783,
0.021175254,
-0.02291942,
0.017455278,
-0.012672449,
0.0043365667,
-0.0025906984,
0.000009361421,
-0.017605167,
0.025876325,
-0.021842944,
-0.013680795,
-0.01700561,
0.01542496,
0.006009194,
0.0021580637,
0.0036245931,
-0.0038903058,
0.0016138637,
0.007705667,
-0.036463954,
0.027456975,
0.015343202,
-0.0033128918,
0.02107987,
-0.016337922,
-0.0019604824,
-0.043086328,
-0.010812461,
0.026012588,
-0.0024391059,
-0.0139396945,
0.009892686,
0.021406902,
0.016010892,
0.020589324,
-0.025590172,
-0.007508086,
-0.005699196,
-0.015493092,
-0.021515911,
-0.003071025,
-0.030086849,
-0.0022636675,
-0.000388988,
-0.011303008,
-0.014593757,
-0.010063015,
-0.0052870004,
0.0023283924,
0.013599037,
-0.0058558984,
-0.002677566,
-0.014743646,
0.006397543,
0.029650807,
0.0070243524,
-0.010996416,
0.0092795035,
-0.000053626904,
-0.022674147,
-0.012658823,
-0.01854538,
-0.03401122,
-0.007814677,
0.0040436015,
0.00903423,
-0.031831015,
-0.023668867,
0.01825923,
-0.006734794,
0.013803432,
-0.0122432215,
0.024949737,
0.014212221,
-0.009334009,
0.013953321,
0.03000509,
-0.02471809,
-0.01821835,
-0.022796784,
0.02519501,
0.0069528143,
-0.004731729,
0.01744165,
0.022592388,
-0.033030126,
-0.028587956,
0.002226195,
-0.032485075,
0.033438917,
-0.001377107,
-0.012849592,
-0.014334857,
-0.0050757932,
-0.008598189,
0.018409118,
0.008461926,
0.0038119548,
-0.012665637,
0.007998632,
0.024350181,
-0.028397188,
0.017795935,
-0.031640247,
-0.015247819,
0.025903577,
-0.0017169125,
-0.022360742,
-0.027961148,
-0.0075353384,
-0.020194162,
-0.009613347,
-0.013142557,
-0.028260926,
0.010308288,
-0.025549294,
0.041451175,
0.027375218,
0.028478947,
0.015533971,
0.017319014,
0.006922155,
0.005290407,
0.013401456,
0.0025515228,
0.014157715,
-0.025644679,
0.0029841575,
-0.0069698473,
-0.0023420185,
0.0043501933,
-0.0073990757,
0.019594606,
0.047773775,
-0.023409966,
-0.00373701,
0.0094770845,
-0.025426658,
-0.026353246,
-0.0037336035,
-0.011541468,
0.011405204,
-0.033111885,
-0.0018020768,
0.0068131452,
-0.002849598,
-0.005498208,
-0.01622891,
0.034201987,
-0.028805977,
0.02718445,
-0.006884683,
0.011534655,
-0.013299259,
0.013898816,
-0.0016675172,
-0.018122965,
0.008455113,
-0.0048066736,
0.012917723,
0.000377065,
-0.02233349,
-0.00037812954,
0.002975641,
-0.02710269,
-0.013851124,
-0.013244754,
-0.010199278,
-0.019826252,
-0.015002545,
-0.0015721332,
-0.025522042,
-0.013415082,
0.0076375357,
-0.024404686,
0.016460558,
-0.0109759765,
-0.023191946,
0.028778724,
-0.004919091,
0.019485595,
-0.025699183,
0.037635814,
0.024173038,
-0.016433306,
-0.033220895,
-0.014566504,
-0.003730197,
0.0022347115,
0.024581827,
0.030059597,
-0.02266052,
-0.018204724,
0.0058354586,
0.020221414,
-0.01774143,
-0.030168606,
0.011623225,
-0.0045375545,
0.0028768505,
0.00397547,
0.0024118533,
-0.031558488,
-0.011541468,
0.0020848224,
0.0053380993,
0.007671601,
0.0008823023,
-0.021624923,
0.02603984,
-0.0040776674,
-0.007467207,
0.0069766603,
-0.008666321,
0.0084891785,
-0.04395841,
-0.020289546,
0.0066496297,
-0.0023300955,
0.03084992,
-0.001904274,
0.009327196,
0.015370456,
-0.003326518,
0.0063362247,
-0.019008674,
-0.012536187,
0.036191426,
0.00049310137,
0.01774143,
0.01821835,
0.014035079,
0.001157383,
-0.029432787,
-0.005634471,
0.014048705,
-0.02229261,
-0.0030250363,
0.032703098,
0.010608067,
-0.012488495,
0.013013107,
-0.03496506,
-0.022687772,
-0.028805977,
-0.038616907,
0.022197226,
-0.0470107,
-0.003927778,
0.015697487,
0.023668867,
0.005610625,
0.002023504,
-0.007664788,
0.009722358,
0.039352726,
-0.017346267,
0.037554055,
0.013810245,
0.0003040366,
-0.044285443,
0.014348484,
-0.011486962,
-0.032239802,
-0.006165896,
-0.016324295,
-0.02967806,
0.004731729,
-0.0064588613,
0.019362958,
0.0027593237,
-0.00087037927,
0.0021103716,
0.009497524,
0.020521194,
-0.0032600898,
-0.0006923859,
0.031640247,
-0.022238106,
-0.00054377416,
0.020207789,
-0.001303014,
0.0032413537,
0.009041043,
0.0075966567,
0.011112239,
-0.005099639,
-0.009184119,
0.015288698,
0.0038834927,
-0.027538732,
-0.009783676,
-0.023205573,
-0.011773115,
-0.011616413,
-0.003064212,
0.018300107,
-0.004128766,
0.003978877,
0.001615567,
-0.007944128,
0.025399406,
-0.010103894,
-0.007814677,
0.008393794,
-0.03771757,
-0.028124662,
0.013728487,
-0.0029552015,
0.041369416,
-0.014375736,
-0.008441486,
-0.02809741,
0.009136427,
-0.022510631,
-0.018654391,
-0.002510644,
0.021038992,
-0.012515747,
0.01436211,
-0.00051183754,
-0.006942595,
-0.005651504,
0.021202506,
0.02016691,
-0.024772596,
0.013892002,
0.015656607,
0.022469752,
-0.010403672,
-0.032267056,
-0.013633103,
0.0111394925,
-0.010383233,
0.006186336,
0.026802912,
-0.015097929,
0.025712809,
-0.0029023997,
0.030713657,
0.0135445325,
0.009524777,
0.014280352,
-0.02332821,
-0.0070788576,
0.009960818,
0.0014316121,
-0.004414918,
0.0055356803,
-0.00043306054,
0.017278137,
0.00021493343,
-0.00094873045,
-0.022715025,
0.028151914,
-0.033956714,
0.020248666,
0.00795094,
-0.003832394,
0.0104649905,
0.018041208,
0.0079305,
0.009776863,
-0.01806846,
-0.0122432215,
-0.0102674095,
0.0000217169,
0.010022136,
-0.0023352054,
0.0072696256,
-0.011752675,
-0.030713657,
-0.007419515,
-0.0027559171,
-0.025126878,
-0.010226531,
0.035564616,
-0.013067612,
-0.017019236,
-0.028478947,
0.0015176281,
-0.010076641,
-0.030441131,
-0.0016624074,
-0.0055969986,
0.0051268917,
-0.015533971,
-0.0033929462,
-0.006690508,
-0.008972912,
0.0029194327,
-0.024472818,
0.002796796,
0.01821835,
0.18662567,
-0.03390221,
0.014075957,
0.005958095,
-0.015724739,
-0.01590188,
0.010941911,
-0.008100829,
-0.00046499714,
-0.01483903,
0.029432787,
-0.0073241307,
-0.0024033368,
-0.000086707914,
0.015697487,
-0.017100994,
-0.0216658,
-0.005208649,
-0.035292093,
-0.015574849,
0.008141709,
-0.010172025,
0.011044108,
-0.011050921,
0.04150568,
0.0032975622,
-0.022415247,
0.019580979,
0.029868828,
0.013455962,
-0.024622707,
0.0081757745,
0.0018259229,
-0.0021205915,
0.012583879,
-0.0022330084,
-0.015493092,
-0.01002895,
0.00675864,
-0.0053006266,
-0.0020746028,
0.0011948553,
-0.013101678,
-0.0050723865,
0.0087685175,
0.036654722,
0.004755575,
-0.0019945481,
-0.013687609,
0.00073539384,
-0.037009005,
0.0006127572,
0.008325663,
0.023260077,
-0.0078623695,
0.007678414,
0.015888255,
0.0075694043,
-0.0048237066,
0.011813994,
0.002071196,
0.0005075793,
-0.023300955,
0.0130335465,
-0.0048066736,
0.026353246,
-0.012250035,
-0.021788437,
0.01780956,
-0.033847705,
0.0033844297,
0.0024544355,
-0.023151066,
0.019008674,
0.0029960806,
-0.035455607,
-0.004302501,
0.013040359,
0.0077874246,
0.022142721,
0.012420364,
-0.023764249,
-0.03995228,
0.020671083,
0.0016607041,
-0.019826252,
0.020889103,
0.024350181,
-0.018409118,
-0.029133009,
0.0033929462,
0.0025872919,
-0.00009580985,
0.0003099981,
0.012944976,
-0.002588995,
0.0029262458,
0.008441486,
0.0048066736,
-0.009688293,
-0.04414918,
0.07379999,
0.014539251,
0.014130463,
-0.0014256506,
0.021979205,
0.0084483,
0.011820806,
-0.023532603,
-0.004956563,
0.031067941,
-0.0092795035,
-0.0021342176,
-0.0015551003,
0.0003219211,
0.008352916,
0.0037710757,
-0.0060705123,
0.015561223,
0.0076307226,
-0.00519843,
0.0014758975,
0.036300436,
0.03442001,
-0.021447781,
0.0021887228,
-0.042323258,
0.007221934,
-0.021911073,
-0.026285114,
0.004990629,
-0.004724916,
0.0061318306,
0.022851288,
0.014389362,
-0.019771747,
-0.0033759132,
0.0032277275,
-0.026230609,
0.021774812,
-0.010539935,
-0.005682163,
0.00842786,
-0.0041253595,
-0.010553562,
-0.028533451,
0.016065396,
0.005706009,
-0.02644863,
-0.011616413,
-0.016406054,
-0.024540948,
-0.008897968,
-0.015356828,
0.035346597,
-0.023151066,
-0.0048577725,
-0.011732236,
0.04003404,
-0.0072628125,
-0.018136593,
0.026298739,
-0.014402988,
-0.029296523,
-0.0046567847,
-0.012761021,
-0.17278136,
-0.010315102,
-0.0035905275,
-0.015874628,
0.029487291,
0.012726955,
-0.00012902393,
-0.0003630129,
-0.013156183,
0.019240322,
0.0464929,
0.009259064,
-0.036899995,
-0.024513695,
-0.00020812028,
-0.016882973,
-0.011507402,
0.051044084,
0.009974444,
0.011412018,
0.041750953,
-0.0022040524,
0.006104578,
0.0025804788,
0.0016419679,
-0.0046329387,
0.02740247,
-0.02122976,
-0.01024697,
-0.019771747,
-0.017932197,
0.005951282,
0.017428026,
-0.011166745,
-0.0065576523,
-0.005004255,
-0.009701919,
-0.011902564,
-0.009347635,
0.026911924,
0.012338606,
0.010308288,
-0.023709744,
0.016065396,
-0.0012399924,
0.05248847,
-0.014116837,
-0.019526474,
0.03570088,
-0.008972912,
0.0084483,
-0.025031494,
-0.012311353,
0.022428874,
0.01447112,
0.00045392578,
-0.008502805,
0.00059359526,
-0.0023198759,
-0.0055424934,
-0.007330944,
-0.01241355,
0.014266726,
0.006360071,
0.011078174,
-0.025508415,
-0.0026452036,
0.03632769,
-0.014266726,
0.001921307,
-0.03398397,
-0.0154385865,
0.019104058,
-0.008223466,
0.04529379,
0.019049553,
-0.008509618,
0.008066764,
0.016583195,
0.00061616383,
-0.022606015,
0.016733084,
-0.023764249,
-0.024091281,
-0.029814323,
0.0105467485,
0.0018276261,
0.020194162,
-0.0014784525,
-0.019989768,
0.03640945,
-0.027129944,
-0.02883323,
-0.0095588425,
0.026026214,
0.026203357,
-0.01652869,
-0.02989608,
-0.008727639,
0.022728652,
0.03125871,
-0.033738695,
-0.015561223,
-0.008979725,
0.03760856,
0.0025395998,
-0.027279833,
0.02097086,
0.06676882,
-0.027674995,
0.008400608,
0.0028598176,
0.0032737162,
0.0168966,
0.0043093143,
0.010921472,
-0.009960818,
-0.014975293,
0.025385778,
-0.040415578,
0.076034695,
-0.009190933,
-0.019131312,
0.021093497,
-0.012250035,
0.0018770215,
-0.12830515,
0.00663941,
0.0020320206,
0.008182587,
-0.013053986,
0.02133877,
-0.0048816185,
0.014348484,
0.0075625908,
0.011234876,
-0.017973077,
-0.0062442473,
0.0011352403,
-0.016215285,
0.027129944,
0.018749775,
0.013340138,
-0.015847376,
-0.013646729,
0.043794896,
0.0075353384,
-0.013428709,
-0.016256165,
-0.013762553,
0.01206608,
0.00675864,
-0.03452902,
0.014062331,
0.016828468,
0.014212221,
0.0139942,
-0.026012588,
0.034665283,
-0.0068880897,
-0.005515241,
-0.010471804,
-0.0062510604,
-0.010628507,
0.0369545,
-0.03030487,
-0.008073577,
-0.0013404863,
-0.0022585576,
-0.015343202,
0.015234192,
-0.0055901855,
-0.039434485,
0.015506718,
0.027129944,
-0.016297042,
-0.037881088,
-0.049872223,
-0.041342165,
-0.015588475,
0.03654571,
-0.014593757,
0.024922485,
0.050880566,
-0.03831713,
-0.02001702,
0.004142392,
0.009306756,
-0.010519496,
0.0141032105,
0.020889103,
-0.018300107,
-0.02079372,
-0.014634635,
0.030931678,
-0.028233673,
-0.0050826063,
0.0013413379,
-0.0146482615,
0.0013072722,
-0.0050962325,
0.004925904,
-0.010260597,
0.004915684,
0.0043365667,
-0.026830165,
-0.0031732223,
-0.01542496,
0.020562071,
0.00076009147,
0.03210354,
0.013558159,
0.01000851,
-0.011119053,
0.00065832015,
0.012686076,
-0.016501438,
0.040906124,
-0.010587627,
-0.018872412,
-0.029460039,
0.0068983096,
0.022156348,
0.0032975622,
0.021979205,
0.014321231,
-0.0037574496,
-0.011813994,
-0.061100286,
0.004987222,
0.003219211,
0.005222276,
-0.011132679,
-0.007644349,
-0.0056072185,
-0.005474362,
0.017782308,
0.019049553,
-0.006448642,
0.026067093,
-0.02387326,
0.001904274,
-0.027893016,
-0.023791503,
0.019444715,
0.00543689,
0.027429722,
0.03485605,
0.010553562,
-0.011316634,
0.012454429,
-0.015166061,
-0.0050791996,
-0.00031234013,
-0.0130335465,
0.0060432595,
-0.0060296333,
-0.0033827266,
-0.0037949218,
-0.040551838,
-0.035755385,
-0.009722358,
-0.002939872,
-0.02644863,
-0.019104058,
0.02618973,
0.025753688,
0.03398397,
-0.00015212475,
-0.017128246,
0.030468384,
-0.0011037295,
-0.0061795227,
0.00905467,
-0.027307086,
-0.00030957226,
0.009088735,
-0.012774647,
0.04902739,
0.0021444373,
0.020330425,
-0.017646046,
-0.0140214525,
0.008312037,
0.0096406005,
-0.010894218,
0.008346102,
-0.002677566,
0.019008674,
0.0063191922,
0.003873273,
-0.003367397,
-0.0009419173,
-0.02872422,
-0.016719459,
-0.005225682,
0.020480314,
-0.03245782,
-0.03812636,
0.033956714,
0.00031319176,
-0.0014239473,
0.009810929,
0.011228063,
-0.012495308,
-0.010240157,
-0.034910556,
0.017278137,
0.01098279,
-0.015479466,
-0.0114528965,
-0.010131147,
0.036927246,
0.0052393083,
-0.015670234,
0.018300107,
0.02133877,
0.018926917,
-0.028233673,
0.0022704806,
0.0055561196,
0.005154144,
0.03452902,
0.01143927,
-0.00028508753,
0.023764249,
0.010144773,
0.034474514,
-0.01386475,
-0.01340827,
0.009681479,
0.00051694736,
-0.01975812,
0.013932882,
-0.00771248,
-0.04469423,
0.009436206,
0.014048705,
0.00903423,
-0.0034372318,
-0.007848743,
-0.007521712,
-0.015411334,
0.005413044,
-0.015166061,
0.011793554,
-0.0021870194,
0.044285443,
0.019799,
0.025576547,
-0.0034355284,
-0.006264687,
0.0091636805,
-0.00026784177,
0.023123814,
0.00029104904,
0.024895232,
-0.00518821,
0.013360578,
0.029242018,
-0.03210354,
-0.021270638,
0.0021972393,
-0.0006889793,
0.015479466,
0.0028410815,
-0.010137959,
0.08540959,
-0.013251567,
-0.04450346,
-0.0049361237,
-0.005879744,
0.015820123,
-0.0050928257,
0.005920623,
-0.019608231,
-0.024513695,
0.005712822,
-0.031122446,
0.023232825,
-0.04646565,
-0.017155498,
0.012611131,
-0.0017203192,
-0.0038937123,
-0.0007524267,
-0.012713329,
-0.0028189388,
-0.028179169,
0.016337922,
0.028887736,
-0.040606346,
-0.010737517,
0.035728134,
-0.011398392,
0.013449148,
0.0006689657,
-0.0020388337,
0.005004255,
-0.03526484,
0.0117663015,
0.014184968,
-0.002498721,
-0.014416615,
-0.025113253,
0.022101842,
0.013060799,
0.0042037107,
0.007460394,
0.0003042495,
-0.0022653707,
0.02545391,
-0.01436211,
-0.020398555,
-0.0026860824,
-0.003760856
] |
This study investigated the association between green tea consumption and leukemia. A total of 252 cases (90.3% response) and 637 controls (53.4% response) were enrolled. Controls were matched for cases on age and gender. Information was collected on participants’ living habits, including tea consumption. Green tea was used as a standard to estimate the total amount of individual catechin consumption. We stratified individual consumption of catechins into four levels. Conditional logistic regression models were fit to subjects aged 0–15 and 16–29 years to evaluate separate associations between leukemia and catechin consumption. A significant inverse association between | [
0.021330811,
0.00043702626,
0.03341696,
-0.050989673,
-0.013526536,
0.0050249835,
0.00062689534,
-0.00030546827,
-0.021121299,
0.001156401,
-0.010613028,
0.028964857,
-0.002453567,
-0.0033619923,
-0.03276224,
0.0029298766,
0.052482437,
-0.008439354,
0.0029577021,
0.025521025,
-0.040959347,
0.014600279,
0.017088218,
-0.008452448,
-0.004226224,
0.0026827194,
0.0070186094,
-0.036978643,
-0.0031868545,
0.0022145938,
0.02734115,
-0.015150244,
-0.024237772,
-0.012518265,
-0.02316403,
-0.018384567,
0.021147488,
-0.0018381292,
0.021330811,
-0.006979326,
-0.00006419335,
0.001276706,
0.0150193,
-0.011824261,
-0.011431429,
0.01513715,
0.013605103,
-0.012996212,
-0.0070840814,
0.03367885,
0.025979329,
-0.008085804,
0.0015164976,
0.026149558,
-0.016341837,
-0.00012674989,
-0.0029462446,
0.0062100287,
-0.0035027573,
-0.019419026,
-0.006016886,
0.0056175063,
-0.02686975,
-0.011320126,
-0.0006436726,
-0.0074769137,
0.0039250525,
0.022915235,
0.008622676,
0.030667132,
0.026162652,
0.047349423,
0.022443837,
0.014194352,
0.003407823,
-0.009663682,
-0.030614754,
-0.012079603,
-0.018607171,
0.0043997252,
0.011843903,
-0.021710549,
-0.018476227,
0.005332703,
-0.0083018625,
-0.00022342354,
-0.006730532,
0.02215576,
0.0072543086,
-0.000004657854,
-0.009388699,
-0.021527227,
0.0023324436,
0.00074310834,
-0.031112343,
0.01863336,
0.0014330206,
0.028100627,
-0.00031406147,
-0.015425227,
-0.00671089,
-0.0065930407,
0.00228825,
-0.0056502423,
-0.035407312,
-0.025154382,
-0.0009141542,
0.004946417,
0.0036697113,
-0.010357686,
-0.054158524,
0.021461755,
0.016682291,
-0.028179193,
0.0075947638,
-0.005211579,
-0.00034679755,
-0.010665406,
-0.021252245,
0.0034503797,
0.00750965,
-0.008648865,
0.03750242,
-0.005090456,
0.028519647,
0.012675399,
-0.024997247,
-0.012505171,
-0.027419716,
-0.003745004,
-0.0075031025,
-0.0036959,
0.021082016,
0.038916618,
-0.034909725,
0.03527637,
-0.004209856,
-0.010940388,
-0.020257069,
-0.020754656,
-0.010580292,
0.0028218476,
0.015529983,
-0.0124266045,
0.0013798245,
0.016276365,
0.025769819,
0.013906274,
-0.02438181,
-0.003447106,
-0.014508617,
-0.021212962,
0.036376297,
0.0051035504,
0.023805656,
0.0104428,
-0.010776708,
0.015857343,
-0.047716066,
-0.017062029,
0.0008945126,
-0.023988977,
0.006926948,
-0.0083018625,
0.0052410415,
0.04046176,
0.020021368,
-0.0072281198,
-0.0048940396,
-0.008445901,
-0.02097726,
0.043499663,
-0.030536188,
0.00711027,
-0.0062951427,
0.0053588916,
0.0050773616,
0.008583392,
-0.022417648,
-0.041247424,
-0.0038301179,
0.042583056,
0.00896313,
-0.014652656,
0.013074779,
-0.008845281,
0.0034012757,
0.0013413597,
-0.02358305,
-0.018201243,
-0.0025272232,
0.020807033,
-0.021396283,
-0.015556172,
-0.6314653,
-0.028179193,
0.0023389908,
0.008655412,
0.03090283,
-0.00048162913,
0.028022058,
0.021396283,
-0.023033084,
0.011444523,
-0.011385598,
0.020073745,
0.014024124,
-0.021396283,
0.010069609,
-0.025350798,
-0.013919368,
-0.009558926,
0.007843558,
0.010102346,
-0.049968306,
0.008092351,
-0.03768574,
0.019104758,
-0.017978638,
0.010344592,
0.03299794,
-0.015831154,
0.010822538,
0.046616137,
-0.015595455,
0.03119091,
0.0059154043,
0.023530673,
0.040330812,
0.008295315,
0.004491386,
0.022496214,
0.0003770784,
0.035197802,
-0.020532051,
-0.011483806,
0.032421783,
-0.001964163,
-0.022037908,
0.021592699,
0.014312201,
0.021160584,
0.015713304,
-0.022090286,
0.022745008,
0.0025877848,
-0.016970368,
-0.015569266,
0.025560308,
-0.0050249835,
0.012387321,
-0.020361824,
-0.0038104763,
0.006678154,
0.008039974,
0.00066658785,
0.006134736,
-0.010095798,
-0.021514133,
0.02482702,
-0.00018383338,
0.00016183885,
-0.0065799463,
-0.002834942,
0.007889388,
0.010691594,
-0.0028005692,
0.0056240535,
0.04962785,
0.008347693,
0.006275501,
0.00045216669,
-0.023648523,
-0.0048711244,
-0.003267058,
0.0008310865,
-0.01579187,
0.017337013,
0.016066853,
-0.008642318,
-0.015595455,
-0.0056797047,
0.014207446,
-0.002013267,
0.009558926,
0.0070578926,
0.0008339509,
-0.020662995,
-0.029200558,
0.011647487,
-0.027681604,
-0.0052672303,
0.0073001394,
-0.051120616,
-0.011915922,
-0.02438181,
0.013395592,
0.010776708,
-0.010815991,
0.02281048,
-0.0068090986,
-0.010743972,
0.045097183,
-0.0136574805,
-0.0014534807,
0.002245693,
-0.005588044,
0.0008814182,
0.01987733,
-0.015281188,
-0.0069662314,
0.012210547,
-0.0055913175,
-0.017192973,
0.027629226,
0.02391041,
0.012943834,
0.0034831157,
0.027943492,
0.016983462,
0.00022772016,
0.0018806861,
0.0041574785,
-0.034438323,
0.0048056524,
0.02212957,
0.015870437,
-0.013297384,
0.02358305,
-0.029645767,
0.023046179,
-0.02210338,
0.006190387,
-0.02227361,
-0.018947626,
0.010154723,
0.011202277,
-0.0047925576,
-0.017101312,
0.010200554,
-0.012878362,
-0.009441077,
-0.009519643,
0.0047270856,
0.004448829,
-0.007666783,
-0.014547901,
0.006894212,
-0.0019527054,
0.0058008283,
-0.02144866,
-0.037161965,
0.012315302,
-0.008216749,
0.00598415,
0.019026192,
-0.018554794,
-0.003836665,
-0.0116278455,
-0.02212957,
-0.011771884,
0.031033777,
-0.018528605,
-0.024853209,
-0.0012439699,
-0.036533434,
-0.0017611996,
0.030326677,
-0.008223296,
0.008570298,
-0.025992423,
-0.0052083055,
-0.007948313,
-0.019654725,
0.0036828057,
-0.0150193,
-0.00085277413,
-0.007843558,
0.022077192,
0.017729845,
0.016813235,
0.017808411,
-0.0104624415,
0.023962788,
-0.018319095,
0.03223846,
-0.019654725,
0.010966577,
0.012308755,
-0.00031140167,
-0.0039479677,
0.0024142838,
0.00948036,
0.009022055,
-0.01004342,
-0.02248312,
0.0013241733,
-0.023242597,
0.012839079,
0.0033112515,
0.0050446256,
-0.021514133,
0.026280502,
0.01839766,
0.02311165,
0.0025255864,
-0.038549975,
0.020780845,
-0.00023569957,
0.007784633,
-0.01750724,
0.0020983808,
-0.0025059446,
-0.02008684,
-0.014587184,
-0.0079679545,
0.00795486,
-0.03522399,
-0.00835424,
0.0057157143,
0.0031688497,
0.025102004,
-0.014600279,
0.0011539458,
-0.015713304,
0.018934531,
0.005133013,
0.012485529,
0.0014395678,
-0.0038399387,
0.021815304,
-0.03297175,
0.044678163,
0.007542386,
-0.012884909,
0.017769128,
0.0039676093,
0.0053359764,
0.011915922,
-0.021867681,
0.012832532,
0.001831582,
-0.017441768,
0.03226465,
-0.0071495534,
0.02959339,
-0.018384567,
-0.0044226404,
-0.0013372677,
-0.0034372853,
0.007876294,
0.03815714,
0.030352866,
0.013945557,
0.031924196,
-0.008125088,
-0.014770506,
-0.0053818068,
-0.023517579,
-0.00033881812,
-0.0045044804,
-0.0009166094,
0.015097867,
-0.02212957,
-0.009991042,
-0.004668161,
0.008341146,
-0.055153698,
-0.0040821857,
0.004026534,
0.02541627,
-0.0022866132,
-0.0023668164,
0.018017922,
-0.011915922,
-0.025376987,
0.022666441,
0.01412888,
-0.0053916276,
-0.010259478,
0.004674708,
0.0028824091,
-0.0049038604,
-0.0013192628,
0.022116475,
0.018934531,
-0.004550311,
0.0021409376,
0.000051022205,
-0.029986221,
0.013866991,
-0.011503448,
-0.0025845112,
0.010815991,
-0.012695041,
-0.021042733,
-0.020073745,
0.007974502,
0.024512755,
0.021252245,
-0.020964166,
-0.017978638,
0.0027727436,
-0.017782222,
0.009094074,
0.010010684,
0.00047303594,
-0.021920059,
0.00055487605,
-0.0028496732,
0.015176433,
0.005011889,
0.0025665064,
-0.009388699,
-0.029776711,
-0.04991593,
-0.010128534,
-0.0064850114,
0.039676093,
0.020021368,
-0.0005867937,
0.009506549,
0.008360787,
0.0045044804,
0.0063376995,
-0.0070186094,
0.0080661625,
-0.0030624575,
-0.014076502,
0.022181949,
0.008740526,
0.0050446256,
-0.0008290405,
0.029200558,
-0.009807721,
-0.038183328,
-0.014993111,
-0.002918419,
0.021501038,
-0.014233635,
0.024303244,
0.03847141,
0.024342528,
0.018567888,
0.014102691,
0.053137157,
0.0072150254,
-0.00638353,
0.01293074,
0.013762236,
-0.0062885955,
0.010416611,
-0.025848385,
0.008053068,
0.02532461,
0.013578914,
0.021396283,
0.017756034,
0.016079947,
0.004049449,
0.0021114752,
-0.007666783,
-0.008164371,
-0.01072433,
0.01628946,
0.001790662,
0.018659549,
-0.025913857,
0.041614067,
0.007529292,
-0.018580982,
-0.0018610444,
0.012001036,
0.011411787,
-0.00056346925,
-0.01140524,
-0.012806343,
-0.0021540322,
0.0033047043,
-0.021946248,
0.03430738,
-0.011608204,
-0.007640594,
-0.010220195,
-0.018973814,
-0.021920059,
-0.006069264,
-0.013447969,
-0.0034765685,
-0.021068921,
-0.042818755,
-0.0029822541,
0.023347352,
0.00711027,
0.014050313,
-0.022260515,
-0.0032948835,
0.015844248,
-0.012498624,
0.0021343904,
-0.006854929,
-0.024263961,
0.026555484,
0.018450039,
0.00618384,
-0.0057975547,
-0.020597523,
0.009329774,
-0.006953137,
-0.012282566,
0.0009788079,
-0.0076144054,
-0.018201243,
0.0009959943,
-0.009395246,
0.0049693324,
-0.0056993463,
-0.008098898,
-0.0041411105,
0.0022669714,
-0.040278435,
-0.007077534,
-0.024918681,
-0.007575122,
-0.008956583,
-0.01638112,
-0.03498829,
-0.0060398015,
0.04679946,
-0.027236395,
0.021422472,
-0.006854929,
0.031007588,
0.032395594,
0.0008437717,
0.021383189,
0.040357005,
-0.030352866,
-0.014181257,
0.008747073,
0.012112339,
-0.0029249662,
-0.0063311523,
0.009211925,
-0.015097867,
-0.000003785106,
-0.016695386,
-0.014286012,
-0.008125088,
0.018934531,
-0.03705721,
-0.010501725,
-0.041064102,
0.0022849764,
-0.008511373,
0.01762509,
0.015477604,
-0.014377673,
-0.01919642,
0.012138528,
-0.009519643,
-0.012695041,
0.030405244,
-0.026922127,
0.013631292,
0.0060463487,
0.021252245,
-0.0024666614,
-0.007699519,
0.00029298765,
0.004802379,
0.015163339,
-0.002602516,
-0.0036533433,
0.0023930052,
0.024604416,
0.05447279,
0.0053981747,
0.03889043,
-0.019301176,
0.011922469,
-0.012590285,
0.0035027573,
0.0052214,
-0.01457409,
0.008275674,
0.006573399,
0.014011029,
0.0028333052,
0.011719506,
0.023858033,
-0.0012464251,
0.007751897,
0.03320745,
-0.009912476,
-0.017179878,
-0.007634047,
-0.027079262,
-0.016996557,
0.031557553,
-0.020296352,
-0.00010316971,
-0.0027138186,
0.0026156104,
0.0064522754,
0.021422472,
-0.00029667045,
0.0024093734,
0.019235704,
-0.025547214,
0.0065635783,
-0.023530673,
-0.015045489,
-0.0018430396,
-0.029252935,
-0.009342869,
-0.020807033,
0.010416611,
0.017991733,
0.010010684,
0.008891111,
-0.008740526,
-0.0070055146,
-0.023884222,
-0.023059273,
-0.025822196,
-0.01581806,
-0.024002071,
-0.007044798,
-0.00971606,
-0.0017857515,
0.001027912,
-0.0050446256,
-0.009205378,
-0.030195734,
0.017978638,
-0.013186081,
-0.010010684,
0.0015533256,
0.0036435225,
0.028624402,
-0.019419026,
0.026136464,
0.011542731,
-0.0082691265,
-0.0049529644,
0.027733982,
0.006108547,
0.0018757756,
0.0038628539,
0.03407168,
-0.029541012,
0.0080661625,
-0.030824265,
0.028833913,
-0.015569266,
-0.00936251,
0.019510686,
0.023897316,
0.013094421,
-0.004641972,
-0.0059284987,
-0.022862857,
0.018332189,
0.016773952,
-0.0033619923,
0.0052312207,
-0.0051821168,
0.0042556864,
0.057091672,
-0.0047761896,
0.008537562,
-0.00056346925,
-0.006763268,
-0.0044062724,
-0.010423158,
-0.0064129923,
0.011994489,
0.010036873,
0.036376297,
0.01128739,
-0.0032146801,
-0.006291869,
-0.024447283,
-0.0041967616,
0.0049365964,
-0.01316644,
0.04289732,
0.025651969,
0.007326328,
0.020479674,
0.0087994505,
0.031505175,
-0.013395592,
-0.00967023,
0.006416266,
-0.054053765,
-0.004674708,
0.012190905,
0.011418334,
-0.015726399,
0.0047598216,
-0.02210338,
0.00074515434,
-0.029829089,
-0.042059276,
0.022705724,
-0.035302557,
0.00048408433,
-0.0032768787,
0.013074779,
0.022378365,
0.0016286185,
-0.031321853,
-0.018594077,
0.028755346,
-0.023661617,
0.0064850114,
0.0015426864,
0.013670575,
-0.011235013,
0.008740526,
-0.011346315,
-0.026738806,
0.024774643,
0.0019363373,
-0.030955208,
-0.052534815,
-0.007136459,
0.005804102,
0.025691252,
-0.014744317,
0.008413165,
0.0031655761,
0.021697454,
0.006854929,
-0.010154723,
0.0066454182,
-0.017598901,
-0.00349621,
0.04216403,
0.00016746536,
0.030221922,
-0.0020067198,
0.019379742,
-0.004193488,
-0.00029626125,
0.0049365964,
-0.037580986,
0.020243974,
0.0041836672,
0.010357686,
0.014705034,
-0.004448829,
-0.014430051,
0.015595455,
-0.005843385,
-0.0013233549,
0.037633363,
-0.0053981747,
-0.014364579,
0.027314961,
-0.027079262,
0.008550656,
-0.020388013,
-0.008360787,
-0.017664373,
-0.0039970716,
0.012688493,
0.010344592,
0.00919883,
0.00465834,
-0.024578227,
-0.011457617,
-0.058663003,
-0.0046616136,
0.009303586,
0.021959342,
-0.012151622,
0.004209856,
-0.02796968,
0.008642318,
-0.017140595,
0.008786356,
-0.010789802,
-0.018384567,
0.016512064,
-0.008825639,
0.0148883555,
-0.01241351,
-0.028310137,
-0.016996557,
0.039623715,
-0.0027465546,
-0.024041355,
0.018266717,
-0.011778431,
0.014246729,
-0.037345286,
0.010213648,
-0.023033084,
-0.005787734,
-0.0021523952,
-0.015045489,
-0.0048449356,
-0.0013814613,
0.011280843,
0.009395246,
-0.0029969853,
-0.019235704,
0.00066986145,
-0.010468989,
-0.025809102,
-0.048213653,
-0.0017857515,
-0.0035093047,
0.0075031025,
0.024277056,
0.00562078,
0.02935769,
0.009892834,
0.005758271,
0.0055814967,
-0.01236768,
-0.019929707,
0.0026548938,
0.008452448,
-0.004281875,
-0.011084427,
-0.009349416,
-0.0039315997,
0.0027547386,
-0.0013249917,
0.01469194,
-0.023831844,
-0.015975192,
0.030143356,
0.015281188,
-0.021186773,
0.0008928758,
0.02935769,
-0.013749141,
-0.019589253,
-0.014076502,
-0.0023357172,
-0.041247424,
-0.021658171,
0.005313061,
-0.0034372853,
-0.011248107,
0.00039692462,
-0.013114062,
-0.021278434,
-0.005188664,
0.17473194,
-0.011935564,
-0.009984495,
0.034752592,
-0.008694695,
-0.0046059624,
0.02212957,
0.015726399,
-0.018607171,
0.008537562,
0.005299967,
-0.006694522,
-0.0035125783,
0.011739148,
0.006416266,
-0.00007406531,
-0.049968306,
-0.031976573,
0.0009460719,
0.009297038,
-0.0018463132,
-0.0015361392,
-0.0008175829,
-0.015739493,
0.00022219594,
0.006190387,
0.0028283948,
0.008642318,
0.017101312,
-0.026110275,
-0.014325296,
-0.008982772,
0.0018675916,
0.011444523,
-0.0030051693,
-0.007031704,
-0.001839766,
-0.030221922,
0.015006205,
-0.014011029,
-0.015425227,
-0.010180912,
-0.027157828,
-0.01072433,
-0.026188841,
0.00943453,
-0.00016664696,
-0.0049758796,
0.00626568,
-0.002926603,
-0.043735363,
-0.00074515434,
0.022745008,
0.0009354326,
-0.0062820483,
0.025455553,
0.04926121,
-0.025481742,
0.01337595,
0.0035191255,
-0.011974847,
0.031452797,
-0.0026107,
0.029252935,
-0.008838734,
0.015385943,
-0.017454863,
-0.014652656,
0.0018021195,
-0.012059961,
-0.019013098,
-0.041221235,
-0.011182635,
0.016368026,
-0.027891114,
-0.013853896,
0.025337704,
0.011293937,
0.018031016,
0.00034884355,
0.0062951427,
0.0039807037,
-0.015084772,
0.0069073066,
-0.011483806,
-0.023124745,
-0.006498106,
0.011313579,
-0.010017231,
0.0055684024,
0.023504484,
0.00072960474,
-0.019982085,
0.030431433,
0.018790493,
0.00008639248,
-0.013434875,
-0.0039479677,
-0.0017006379,
0.0017448314,
-0.04274019,
0.058348738,
-0.0009387063,
0.044128194,
-0.0079352185,
0.025193665,
-0.01457409,
0.0071168174,
0.0039315997,
0.00009319544,
-0.0062951427,
-0.040749837,
0.012190905,
0.0011351225,
-0.019157136,
0.00062198495,
-0.02076775,
-0.01703584,
0.0015140424,
-0.002510855,
-0.013382497,
-0.031295665,
0.015713304,
0.04111648,
0.0007021883,
0.006743626,
-0.025704347,
-0.009218472,
-0.007136459,
-0.011254654,
-0.021645077,
-0.03564301,
-0.008531014,
0.0153204715,
0.006854929,
-0.00018577708,
-0.0012341491,
-0.0031688497,
0.010292214,
-0.005106824,
0.004186941,
-0.03949277,
0.011346315,
-0.008138183,
0.0036435225,
-0.014521712,
-0.02686975,
0.01602757,
-0.028781535,
-0.023596145,
-0.008314957,
0.00048490276,
-0.018384567,
0.004242592,
0.014587184,
-0.017638184,
-0.0071233646,
-0.044887673,
0.02654239,
0.0298029,
-0.01281289,
0.006514474,
0.042635433,
-0.011745695,
-0.003340714,
0.009244661,
-0.1631041,
0.0021262064,
0.015150244,
-0.011483806,
0.006763268,
0.041037913,
0.022470025,
-0.007732255,
0.008838734,
-0.004465197,
0.038602352,
-0.008092351,
-0.04216403,
-0.023674712,
0.015372849,
-0.0087339785,
0.0021098384,
0.038078573,
0.048161276,
0.027655415,
0.016368026,
-0.02212957,
-0.0016515338,
0.0010704688,
0.012498624,
0.01934046,
0.0050249835,
0.004916955,
-0.016983462,
-0.005097003,
-0.026319785,
0.021631982,
0.0077977274,
-0.021029638,
-0.005908857,
-0.0011212097,
0.0059710555,
0.0007574304,
-0.0049987948,
-0.0006948227,
0.02959339,
0.009454171,
-0.003208133,
0.00018495868,
-0.03244797,
0.04355204,
0.020505862,
-0.0014837615,
0.015071678,
0.0019085117,
0.032866996,
-0.034176435,
0.034490705,
0.008328051,
0.008393523,
0.012721229,
0.008452448,
-0.01422054,
-0.002545228,
0.015778776,
0.010475536,
-0.02574363,
0.004465197,
-0.0061478303,
0.012230189,
-0.029698145,
-0.03886424,
0.01027912,
-0.004327706,
0.01241351,
-0.04132599,
0.010691594,
0.01422054,
0.0038726747,
0.024211584,
0.016485875,
0.006216576,
0.005787734,
0.019117853,
-0.0067239846,
-0.013461064,
0.010521366,
-0.013880085,
-0.0021622162,
-0.012439699,
0.0020607344,
0.029619578,
0.019510686,
-0.007136459,
-0.036376297,
0.037214343,
-0.021762926,
0.011117163,
-0.02506272,
0.016970368,
0.01072433,
-0.00590231,
-0.007201931,
-0.0015893353,
-0.014325296,
0.01750724,
-0.050753973,
-0.03001241,
-0.010907652,
0.032631297,
-0.029174369,
-0.025665063,
-0.0035747767,
0.029200558,
0.003232685,
-0.003911958,
0.00830841,
-0.00035702754,
-0.010069609,
-0.00870779,
0.014744317,
-0.008491731,
-0.013578914,
-0.015202622,
-0.010023778,
0.02888629,
-0.008747073,
0.010501725,
0.017088218,
-0.0013683669,
0.011634393,
-0.10376018,
0.001831582,
0.0059383195,
-0.002031272,
0.009735702,
-0.0014076502,
-0.015451415,
0.0058401115,
0.0023733636,
0.03569539,
-0.017337013,
0.0031279295,
-0.014141974,
0.0015786961,
0.022077192,
0.00014516393,
0.0074048946,
-0.025848385,
-0.021514133,
0.031295665,
-0.01389318,
-0.020937977,
-0.0019314269,
-0.014993111,
0.0063802563,
-0.011699865,
-0.017271541,
0.006848382,
0.026804278,
0.030536188,
0.04014749,
0.004795831,
0.004648519,
-0.02257478,
-0.0043899044,
-0.0020247246,
-0.008694695,
-0.02429015,
0.026175747,
-0.017782222,
-0.0019216061,
0.025678158,
0.0051199184,
-0.02123915,
0.0024273782,
-0.0104428,
-0.021749832,
0.019117853,
0.010004137,
-0.027891114,
-0.008478637,
-0.012387321,
-0.002212957,
0.009041697,
0.0151895275,
-0.0060561695,
0.012884909,
-0.014757412,
-0.017677467,
-0.0112284655,
0.00618384,
0.015163339,
-0.009951759,
-0.0111957295,
0.032500353,
-0.019013098,
-0.017520335,
-0.0031966753,
0.015451415,
-0.010089251,
0.00017114816,
-0.0076536885,
-0.018921437,
0.0073328754,
-0.013919368,
-0.012734324,
-0.014678845,
0.004599415,
0.022587875,
-0.01934046,
-0.014796695,
-0.00767333,
-0.018227434,
-0.006632324,
0.043499663,
0.00054587366,
-0.0005917041,
0.008347693,
-0.023334257,
-0.004988974,
-0.000052198655,
0.038261894,
-0.00055487605,
-0.024669887,
-0.009441077,
0.030248111,
0.0032130433,
-0.019497592,
0.029043425,
0.016747763,
-0.0020771024,
-0.03611441,
-0.052691948,
0.0064751906,
0.0018921437,
0.0044291876,
0.00887147,
-0.0066192294,
0.027157828,
-0.009473813,
-0.004121469,
0.014521712,
0.014862167,
0.023347352,
-0.017363202,
-0.014259824,
0.0001321718,
-0.026974505,
0.024093732,
0.0077649914,
0.04017368,
0.024408,
0.006439181,
0.012780154,
0.03362647,
0.024473472,
0.0018250349,
0.018777398,
0.003199949,
0.0055520344,
-0.026385257,
-0.007483461,
0.02844108,
-0.020401107,
0.012511718,
-0.013605103,
-0.0010205464,
-0.044154383,
-0.0049922476,
0.01884287,
0.027445905,
0.0010721056,
0.009048244,
-0.010338045,
0.008642318,
0.01842385,
-0.011542731,
0.021343905,
-0.037659552,
-0.0018168509,
0.029986221,
0.017886978,
0.0107963495,
-0.0045568584,
0.015726399,
-0.007732255,
0.010305309,
-0.0025501384,
0.009984495,
0.021920059,
-0.014430051,
-0.022286704,
0.00068131904,
-0.000534416,
-0.01389318,
0.00080039643,
-0.011929017,
-0.02888629,
-0.009722607,
-0.0047925576,
-0.028729158,
-0.023858033,
0.008373882,
-0.008930394,
0.012852173,
-0.010357686,
0.008923847,
0.012046866,
-0.0018577708,
0.0008122632,
-0.010187459,
0.034647837,
-0.017913166,
-0.011202277,
-0.016512064,
0.0058728475,
0.038916618,
0.034647837,
-0.003424191,
0.017454863,
0.018620266,
0.009774985,
0.0061052735,
0.004779463,
0.015687115,
0.0016875434,
-0.002577964,
0.042137843,
-0.0038235707,
-0.0073001394,
0.01236768,
0.042399734,
0.017572712,
-0.0015115872,
-0.019903518,
-0.022836668,
-0.013513441,
-0.012099245,
-0.027655415,
-0.03750242,
-0.027079262,
0.022299798,
0.027288772,
0.022679536,
-0.024984153,
-0.0006543118,
-0.001317626,
-0.0084328065,
-0.017821506,
-0.0087339785,
-0.0083018625,
0.041902144,
0.0018103035,
0.0150193,
0.017101312,
-0.000899423,
0.027079262,
0.016394215,
0.03137423,
0.008976225,
0.02248312,
0.004697623,
-0.012668852,
0.007280498,
-0.033547904,
-0.007077534,
0.007195384,
-0.015399038,
0.025010342,
0.009257755,
-0.002163853,
0.060862865,
-0.0059939707,
-0.02311165,
0.0035911447,
-0.011889733,
0.016512064,
0.0302743,
0.014927639,
0.003381634,
-0.039780848,
0.0009812631,
-0.021841493,
0.0043735364,
-0.047035158,
-0.027838737,
0.00671089,
0.013153345,
0.015058584,
-0.012537907,
-0.017729845,
0.008445901,
-0.0032981571,
0.004337527,
0.015962098,
-0.011830809,
0.008098898,
0.010095798,
-0.0035944183,
-0.013853896,
-0.018790493,
-0.009382152,
-0.0008609581,
-0.0354335,
-0.010403517,
0.022653347,
-0.003564956,
-0.015490699,
-0.054629922,
0.04397106,
0.00056060485,
-0.0060954527,
0.032343216,
-0.025822196,
-0.007195384,
-0.012073056,
-0.019183325,
-0.028598214,
-0.028493458,
-0.015647832
] |
RNA polymerase II is implicated in the RNA-templated RNA synthesis during replication of viroids and Hepatitis Delta Virus (HDV); however, neither the RNA template nor protein factor requirements for this process are well defined. We have developed an in vitro transcription system based on HeLa cell nuclear extract (NE), in which a segment of antigenomic RNA corresponding to the left-hand tip region of the HDV rod-like structure serves as a template for efficient and highly specific RNA synthesis. Accumulation of the unique RNA product is highly sensitive to alpha-amanitin in HeLa NE and only partially sensitive to this drug in NE from PMG | [
-0.037708305,
-0.005560502,
-0.0250005,
-0.020889545,
-0.018546166,
0.021117186,
-0.024879983,
0.029566739,
-0.01004305,
-0.0075657642,
0.015908191,
0.0023115755,
-0.006755625,
-0.0016621248,
0.0012336214,
0.0018562904,
0.019778114,
-0.014475383,
0.011274998,
0.0021207575,
-0.022000976,
0.00016518726,
-0.0016102357,
-0.02118414,
-0.00729795,
0.008248691,
0.018894326,
-0.04416264,
-0.02739744,
-0.005818274,
0.012707806,
-0.022215227,
0.0032824036,
0.0019416563,
-0.00071096426,
-0.009018659,
0.00097250205,
-0.008369208,
0.012707806,
0.025884287,
0.032994766,
0.035271194,
-0.0015139898,
0.005078436,
0.0030982809,
0.0135782035,
0.012091832,
-0.007143956,
-0.0033493573,
0.02536205,
0.01972455,
0.008985182,
-0.0039067464,
0.00037075594,
-0.009440467,
0.0056174127,
0.0019901977,
0.005453376,
0.002072216,
-0.01934961,
-0.012707806,
-0.001216046,
-0.01697945,
0.005727886,
-0.009326646,
0.032378793,
0.004941181,
0.0007837764,
-0.00084403466,
0.0045695878,
0.02336683,
0.021210922,
-0.023956023,
-0.0120985275,
0.02408993,
-0.016122444,
-0.008315645,
-0.016350085,
0.006544721,
0.018305132,
0.0124199055,
-0.004177909,
-0.010585375,
0.025214752,
0.024933547,
-0.0059354426,
-0.0061496943,
0.036288887,
0.026004804,
-0.021210922,
0.03122719,
0.038243935,
0.036610264,
0.024384527,
-0.011341951,
0.012828323,
0.0034347232,
0.01497084,
-0.008134871,
-0.011957925,
-0.024732685,
0.008918229,
-0.011107613,
-0.001998567,
-0.004780492,
0.021117186,
0.015814457,
-0.0013265195,
-0.0037795345,
-0.0031903423,
-0.02628601,
0.016028708,
-0.0022061234,
-0.038913473,
0.022469651,
-0.006712105,
0.06320426,
0.005215691,
-0.013912972,
-0.016684854,
0.016028708,
0.036449578,
0.005647542,
-0.024853202,
0.044430453,
0.0011114309,
0.0028706384,
-0.0050081345,
-0.011261607,
0.020340525,
0.021867068,
-0.003689147,
0.020501213,
0.01169011,
-0.016309913,
0.0122458255,
-0.03709233,
-0.018037317,
-0.010645634,
-0.025629863,
0.0065078964,
0.026567215,
-0.015412734,
0.005868489,
-0.002115736,
0.0031685822,
0.02445148,
-0.0068158833,
0.021612644,
0.0037192763,
0.0032941205,
-0.026674341,
0.03358396,
-0.0038029684,
-0.011141091,
0.030798687,
-0.01751508,
0.024036366,
-0.00026635005,
-0.016939279,
0.0034682,
-0.0156002045,
0.010357732,
0.00055153086,
-0.0036288889,
0.028736515,
0.008516506,
-0.0047637536,
0.013618376,
-0.024719294,
-0.011482554,
0.0130358795,
-0.047510322,
0.023420393,
-0.00832234,
0.008590155,
0.0024036367,
0.023152579,
-0.00416117,
-0.023648035,
0.001934961,
0.014515555,
0.0138995815,
-0.0052859923,
-0.013584899,
0.005255863,
0.0049210945,
-0.011636548,
-0.00011015971,
0.0022596864,
-0.010926839,
-0.012553813,
0.016497383,
-0.014957449,
-0.6436122,
-0.03377143,
0.0042448626,
-0.022308962,
-0.0044557666,
0.009165958,
-0.0012445013,
-0.006303688,
-0.02662078,
0.031200409,
-0.0047336244,
-0.0109870965,
0.020434259,
-0.015814457,
-0.014622681,
-0.040975645,
-0.0048809224,
0.004633194,
0.01059207,
0.0011398862,
-0.036851298,
-0.007538983,
0.0064543337,
0.01805071,
0.0063907276,
-0.007264473,
0.02663417,
-0.010705891,
-0.0067188004,
0.040466797,
-0.006153042,
0.029298926,
-0.017193701,
-0.005453376,
0.04475183,
0.006923009,
-0.0020705422,
0.026486872,
0.038806345,
0.0066250656,
-0.013658548,
0.0023584429,
0.004777144,
0.01699284,
0.002791968,
0.010411295,
-0.004703495,
0.013096137,
-0.0026496914,
-0.0143682575,
0.007592546,
0.016577728,
-0.011522726,
0.008637023,
0.00069506274,
0.009366818,
0.017099967,
-0.019737942,
-0.002750122,
0.004516025,
-0.004981353,
0.017287437,
-0.012527031,
-0.015533251,
-0.007813493,
-0.022402696,
-0.016497383,
0.014769979,
-0.0017156877,
-0.0092128245,
0.005784797,
0.024719294,
0.0022596864,
0.009795321,
0.0016562664,
0.021478737,
0.003046392,
0.0050416114,
0.003416311,
0.01971116,
-0.019188922,
-0.012553813,
-0.021505518,
0.023768552,
0.017006231,
-0.00460976,
-0.03634245,
0.034226716,
0.0021860374,
0.0037125808,
0.01664468,
0.012660938,
0.00552033,
-0.014944059,
-0.05313443,
0.016015317,
0.0029426138,
0.004144432,
0.009299864,
-0.022603558,
0.009654718,
-0.026741294,
0.0018763766,
-0.016457211,
0.036717393,
-0.0044323327,
-0.034066025,
0.0029208537,
0.0478317,
-0.018305132,
-0.0008076286,
-0.009962706,
-0.02972743,
-0.012848409,
-0.0041009123,
-0.02501389,
0.03232523,
0.0026681037,
0.0015416082,
-0.03342327,
0.012446687,
-0.01104066,
-0.0027216666,
0.011442382,
-0.0043419455,
0.011395514,
-0.009333341,
-0.031468224,
-0.014395039,
0.0026731251,
-0.0020588252,
-0.0036857994,
0.025911069,
-0.028495481,
0.032030635,
0.011221435,
0.021117186,
0.014636071,
0.005329512,
-0.0408953,
-0.011897666,
-0.0023417044,
-0.00090889604,
-0.005423247,
-0.0063572507,
-0.03160213,
-0.014796761,
0.00575132,
0.017823067,
-0.00783358,
0.010846494,
-0.008469639,
0.001975133,
0.015760893,
0.022576777,
-0.0151315285,
0.0009925881,
-0.033851776,
0.0011281694,
0.0019081795,
0.020220008,
0.01933622,
-0.0009967728,
0.023674818,
-0.015091357,
-0.020849371,
0.017916802,
0.011924448,
0.008228606,
-0.039529447,
0.023661425,
0.005922052,
-0.0067623206,
-0.009025355,
0.0023718337,
0.011743673,
0.010237216,
0.0034882862,
-0.0002215748,
-0.0067522773,
-0.00630034,
-0.013611681,
-0.001088834,
-0.0048474455,
0.024063148,
0.0027400788,
0.046867568,
0.017247265,
0.030798687,
0.03192351,
-0.0063605984,
0.009902447,
-0.0057078004,
-0.0047436673,
0.004365379,
-0.0077331485,
0.027665256,
0.02137161,
0.01566716,
0.025924461,
0.0022345786,
-0.021505518,
-0.0018428997,
-0.032405574,
0.0008544962,
-0.008811102,
0.0020487823,
-0.010719283,
0.0010319235,
0.00985558,
-0.005510287,
-0.008315645,
-0.014903886,
-0.005178866,
-0.0070234397,
-0.009252997,
-0.0034748954,
0.0069698766,
-0.0067723636,
-0.020353915,
-0.015720721,
0.005436638,
0.007967486,
-0.013765674,
-0.008958401,
-0.0080277445,
-0.005061697,
0.021036843,
0.007190824,
0.011422296,
-0.0053194687,
-0.008770931,
-0.0024404612,
0.021813504,
0.013203263,
0.01877381,
0.00013003657,
0.0034012464,
0.03270017,
0.011904363,
-0.007920619,
-0.0067388867,
-0.013350561,
0.005322817,
0.01845243,
-0.004947876,
0.034789126,
0.00028078695,
-0.017997146,
0.014328085,
-0.015975146,
0.0112348255,
-0.020782419,
0.0075523737,
0.007920619,
-0.013939753,
0.014461992,
0.016176006,
0.057258777,
0.028629389,
0.010645634,
-0.003997134,
-0.022228617,
-0.0073180357,
-0.014261131,
-0.0036088028,
0.003541849,
-0.008523202,
-0.01644382,
0.020594949,
-0.003997134,
-0.00096664357,
0.024170274,
-0.017809676,
0.018720245,
0.0010896709,
-0.0076528043,
0.011569594,
0.022362525,
0.0015784327,
-0.02518797,
-0.03101294,
0.029138235,
-0.0012076768,
-0.0043118163,
-0.02758491,
-0.00748542,
0.0014010055,
0.0052792965,
0.017823067,
0.0121721765,
0.007230996,
0.011241521,
0.028174104,
-0.006641804,
-0.019108577,
0.04416264,
-0.006769016,
0.012553813,
-0.025442393,
-0.0030212842,
-0.00013840578,
-0.004482548,
-0.021505518,
0.026553825,
-0.00017303339,
0.016135834,
0.0038531835,
-0.008737453,
-0.007378294,
0.02390246,
0.011516031,
0.016055489,
-0.0284687,
-0.013042575,
0.017086577,
-0.030825468,
0.0024873288,
0.011757064,
0.0012670981,
-0.005955529,
-0.0138995815,
-0.00051763555,
-0.0045126774,
0.021077015,
0.019483518,
-0.015908191,
0.010980401,
0.009781931,
0.011254911,
0.0016654725,
-0.051018696,
0.022242008,
-0.026219057,
0.0038866603,
-0.005486853,
-0.000047652182,
0.018854152,
0.009266388,
0.0047101905,
0.012908667,
-0.020956498,
-0.0074720294,
-0.0051253033,
0.013176482,
0.01460929,
0.011663329,
0.014261131,
0.011890971,
-0.009313256,
0.020956498,
0.005095174,
0.010424686,
-0.011978012,
-0.015734112,
-0.0031920162,
-0.018840762,
0.0077867117,
0.0063739894,
-0.03537832,
0.0062635154,
0.0029878074,
0.019175531,
0.02482642,
0.002241274,
0.023768552,
0.009781931,
0.0026363006,
0.009279778,
-0.012667634,
-0.0053596413,
0.0019684378,
-0.016390258,
-0.022951717,
0.0066752806,
-0.0013700394,
-0.010103309,
-0.023956023,
-0.0021441912,
-0.0019701116,
-0.015037794,
-0.006501201,
0.000267187,
-0.00976854,
-0.013966535,
-0.01104066,
0.00858346,
-0.01176376,
-0.0027317097,
-0.0024605473,
-0.0050282204,
0.0022981847,
-0.0050918264,
-0.0057345815,
0.01287519,
-0.021385001,
-0.022831202,
0.0034012464,
0.02062173,
0.012928753,
-0.0023601167,
-0.022215227,
0.010384514,
0.013912972,
-0.013846018,
-0.03195029,
0.016176006,
-0.032566264,
-0.01176376,
0.021639425,
-0.002611193,
-0.014314694,
-0.008938314,
-0.01932283,
0.022938326,
-0.0019634163,
0.04692113,
-0.005148737,
-0.00096329587,
0.016015317,
0.024772856,
0.043734137,
-0.00009582744,
-0.0042883824,
-0.014769979,
-0.045742746,
-0.0074385526,
-0.036422797,
-0.0008524039,
-0.02209471,
-0.01877381,
0.0013809194,
-0.02609854,
-0.02479964,
0.023018671,
0.0050081345,
-0.011100918,
0.012747979,
0.025723599,
0.017220484,
0.0008821146,
0.009621242,
-0.008958401,
0.0011750369,
-0.005922052,
-0.011495945,
0.017367782,
-0.004850793,
-0.012352952,
0.011850799,
0.047028255,
-0.020487823,
-0.003625541,
-0.004760406,
0.004536111,
0.03398568,
0.007043526,
-0.019255875,
-0.016698245,
-0.013638462,
-0.0022613602,
-0.011837409,
0.01148925,
-0.018572947,
0.002197754,
-0.006524635,
0.0026245837,
0.010585375,
-0.006655195,
-0.0255763,
0.0014939037,
0.029298926,
0.0031133455,
-0.0029108108,
0.004736972,
-0.017073186,
-0.0058417073,
-0.0066451514,
-0.007739844,
-0.01751508,
-0.0042381673,
-0.0065514166,
0.021130577,
0.013765674,
0.048715487,
0.0041912994,
0.0044022035,
0.0036824518,
0.014810151,
0.016899105,
0.0077666254,
0.012044965,
-0.0030581087,
0.020755637,
0.031173628,
-0.013544727,
0.0004059066,
-0.01664468,
0.00803444,
0.006260168,
0.006330469,
-0.027102845,
0.012486859,
-0.026259229,
-0.032110978,
0.0014754914,
-0.0065279827,
-0.010310865,
-0.029968461,
0.0021877112,
0.0082018245,
-0.0018797242,
0.03028984,
-0.02028696,
0.013886191,
0.006280254,
0.013531337,
0.0050416114,
0.03452131,
-0.029834554,
0.0048775747,
-0.008188434,
0.02007271,
0.028709732,
0.012580594,
-0.014877105,
0.01569394,
0.017006231,
0.007739844,
0.016765198,
-0.025603082,
-0.032512702,
-0.01988524,
-0.0067489296,
-0.0235543,
-0.03358396,
-0.015493079,
-0.040065076,
-0.005152085,
0.008563374,
0.0047637536,
-0.010223825,
-0.020233398,
-0.015747502,
0.025937852,
-0.020233398,
0.04424298,
-0.014957449,
0.020139663,
0.024946937,
-0.0067388867,
-0.054955572,
-0.010471554,
0.015211874,
-0.011770455,
0.025442393,
0.02554952,
-0.00775993,
-0.006541373,
0.007338122,
0.012192263,
-0.00391679,
-0.03489625,
0.034574874,
-0.014020098,
-0.0016445494,
0.0033326189,
-0.003478243,
-0.021652816,
0.03382499,
-0.022483042,
0.01789002,
0.005744625,
-0.005560502,
-0.01158968,
0.009346732,
-0.0028371618,
0.023219531,
-0.013216654,
-0.014100443,
-0.0059387903,
-0.037333366,
-0.009058831,
0.01331039,
-0.012406515,
0.025924461,
-0.0009038745,
-0.007867056,
-0.0058082305,
-0.0031702563,
0.0077264532,
0.009641328,
-0.006588241,
0.033316147,
-0.012975621,
-0.0014637746,
0.034280278,
0.013658548,
0.009781931,
-0.0074184663,
0.0062769065,
-0.008657109,
-0.007646109,
0.009333341,
0.0020471085,
0.004937833,
0.00560737,
0.0052926876,
-0.006608327,
0.002432092,
-0.037708305,
-0.027451003,
0.015292218,
-0.040868517,
-0.02189385,
-0.012587289,
0.018653292,
0.009326646,
0.0019466779,
0.009239607,
-0.0084227715,
0.020166446,
-0.019376392,
0.008898143,
0.010638937,
0.004271644,
-0.006588241,
-0.014488773,
0.0030330012,
-0.027477786,
0.023393612,
-0.032646608,
-0.015774284,
0.0030279795,
-0.004271644,
0.014542337,
0.025683427,
-0.014448602,
0.027959852,
0.002251317,
0.008067917,
-0.0063739894,
-0.00019019026,
0.03192351,
-0.010993793,
0.008262083,
0.0008754192,
-0.00087290845,
-0.024491651,
0.011435687,
-0.01825157,
-0.009420381,
-0.010806322,
-0.013029184,
0.010558593,
-0.0044658096,
-0.0063103833,
-0.00966811,
0.011060745,
0.0024371136,
-0.004281687,
0.0016755156,
-0.0048139687,
-0.027772382,
-0.015359172,
0.0045093293,
0.0068560555,
0.005835012,
-0.02755813,
0.0031418009,
0.014622681,
-0.031682476,
-0.024732685,
-0.008362513,
-0.0062099528,
0.04539459,
0.016564338,
-0.0065781977,
-0.016350085,
-0.018492604,
-0.040091857,
-0.015037794,
0.0024772857,
0.0045294156,
0.010411295,
0.017568642,
-0.012406515,
-0.0030430441,
-0.017381173,
0.00030986994,
0.0017843152,
-0.012901972,
0.012205654,
-0.019590642,
0.013712111,
0.015948365,
-0.029647084,
0.00579484,
0.023674818,
0.009915838,
-0.048286986,
0.01881398,
-0.015493079,
-0.006541373,
-0.022483042,
0.0076260227,
-0.02137161,
0.02063512,
-0.009587766,
-0.026018195,
-0.03047731,
0.015104747,
0.009969401,
-0.03248592,
0.0036590178,
-0.010056441,
0.013276912,
-0.0064878105,
-0.016149225,
-0.03703877,
0.016537556,
-0.018559556,
0.0032907727,
0.0037494055,
0.009353427,
0.018184615,
0.005727886,
-0.012821628,
-0.0063103833,
-0.008811102,
-0.019684378,
-0.0080277445,
0.03336971,
0.0044892435,
-0.018023927,
0.0068359696,
-0.00033958064,
-0.02937927,
-0.008637023,
0.006648499,
-0.0075657642,
-0.024223836,
0.0035184151,
0.0073448173,
0.013290303,
0.0076260227,
-0.0028271186,
-0.00024396242,
-0.009480639,
0.0107661495,
0.01805071,
0.017608814,
0.006842665,
-0.0056441943,
-0.0093936,
-0.009252997,
-0.0022998585,
-0.0064242044,
-0.025321877,
-0.00003857682,
0.18297099,
-0.00729795,
0.0030848903,
0.008302255,
-0.02940605,
-0.008998573,
0.019818285,
0.000078827485,
0.0029442876,
0.005845055,
0.037333366,
-0.009045441,
-0.009708282,
0.0018797242,
-0.004556197,
-0.015760893,
-0.025455784,
-0.017006231,
-0.024143493,
0.009112394,
0.010638937,
-0.013082746,
0.018358696,
-0.0042046905,
0.03189673,
0.005222386,
-0.046278376,
0.00575132,
0.0039803954,
0.00010440587,
-0.033878557,
-0.023835506,
0.003956962,
0.014461992,
0.010752759,
0.008195129,
-0.018037317,
0.0036757563,
0.0077130627,
0.0046264986,
0.0019650902,
0.022362525,
-0.012707806,
-0.0151315285,
0.008489725,
-0.001785989,
0.0043754224,
-0.008603547,
-0.01177715,
0.0050382633,
-0.036208544,
-0.008971792,
0.0033142066,
0.023232922,
0.01752847,
-0.0002215748,
0.0016905802,
0.013517945,
-0.012681025,
0.026768077,
-0.0032221454,
0.008369208,
-0.023112407,
0.013618376,
-0.024143493,
0.03631567,
-0.013477773,
-0.03270017,
0.015171701,
-0.025415612,
0.03173604,
-0.006313731,
-0.015734112,
0.018171225,
-0.025857506,
-0.012520336,
0.020916326,
0.018037317,
0.017983755,
0.016001927,
0.007632718,
0.00666189,
-0.044591144,
0.0072376914,
0.004261601,
-0.024130102,
0.03500338,
-0.0065179397,
-0.019242484,
0.0061965617,
0.0037293192,
-0.020420868,
-0.03304833,
0.011007183,
-0.007030135,
-0.0031066502,
-0.022844592,
-0.008824494,
0.0075322874,
-0.023982804,
-0.0361282,
0.08023728,
-0.0027668604,
-0.004485896,
-0.007157347,
0.0375744,
0.0029878074,
-0.0030246319,
0.008710672,
-0.008831189,
0.011743673,
-0.021666206,
0.015921582,
-0.017300827,
0.006404118,
0.021130577,
0.020474432,
-0.036262106,
0.01789002,
0.016176006,
-0.0072912546,
0.0014545685,
-0.0077733207,
0.016577728,
-0.013939753,
-0.0030648042,
-0.016189396,
0.0039301803,
-0.009252997,
-0.021599254,
-0.003235536,
0.011241521,
0.018680073,
-0.003022958,
0.016899105,
-0.012721197,
0.04019898,
-0.019925412,
-0.017582033,
0.0048909653,
0.0046767136,
-0.0067154528,
0.023514127,
-0.007753235,
0.006568155,
-0.011636548,
0.010310865,
0.015198482,
-0.014033489,
-0.0030045458,
-0.035190847,
-0.02208132,
-0.0029560043,
0.014716417,
0.0033008158,
-0.0069297045,
-0.012165481,
-0.026366355,
-0.009875666,
-0.0022914894,
-0.03693164,
0.0105452025,
0.010665719,
-0.013450992,
-0.011194653,
-0.006494506,
-0.1697945,
-0.0068895323,
-0.010310865,
-0.027665256,
0.024866592,
0.019992365,
0.0012821627,
0.0019132011,
-0.0045227204,
0.009366818,
0.020849371,
0.0019215703,
-0.03141466,
-0.027799163,
0.004549502,
-0.017381173,
-0.018907716,
-0.007632718,
0.025067452,
-0.014783369,
0.019296046,
-0.0416184,
-0.0095074205,
-0.014515555,
0.005540416,
0.023259705,
-0.0058852276,
-0.009246302,
-0.002209471,
-0.021210922,
-0.0068895323,
0.021197531,
0.024933547,
-0.011415601,
0.034387402,
-0.00894501,
0.014207568,
0.018586338,
-0.008402686,
0.025268314,
0.028575825,
0.020420868,
0.009052136,
-0.01588141,
-0.016765198,
0.043894824,
0.009641328,
-0.016376868,
0.026044976,
0.008241996,
0.013738893,
-0.011094223,
0.011743673,
0.00976854,
0.008623633,
0.0031250624,
-0.00460976,
0.03709233,
-0.0011189631,
0.009473944,
-0.016122444,
-0.011696806,
0.032405574,
-0.0111611765,
0.00985558,
-0.03379821,
-0.021585863,
0.0038766174,
-0.029647084,
0.020675292,
-0.029486395,
-0.019028232,
-0.009045441,
-0.025603082,
0.017140139,
0.010237216,
-0.033128675,
0.020501213,
-0.0036991902,
-0.014716417,
-0.00315017,
0.015426125,
-0.0060090916,
-0.03452131,
-0.0040540444,
-0.008837884,
0.009480639,
0.025670037,
-0.00460976,
0.002251317,
0.017595423,
-0.019456737,
0.015318999,
-0.01160307,
-0.0033711172,
0.011114309,
0.020514604,
-0.011957925,
0.0005665954,
-0.017568642,
0.03304833,
-0.0006628413,
-0.007900532,
0.024223836,
0.022188446,
-0.008770931,
-0.03267339,
0.013792455,
0.06540034,
0.009252997,
-0.008355818,
0.021451956,
0.009052136,
0.014020098,
-0.0075322874,
0.03545866,
-0.010819713,
-0.0073515126,
0.00010147665,
-0.016135834,
0.0654539,
0.017608814,
-0.006461029,
0.020862764,
-0.010531812,
-0.021853678,
-0.13015793,
-0.015747502,
-0.002137496,
0.023219531,
0.0023768551,
0.03977048,
0.0023634646,
0.039288413,
-0.017140139,
0.016457211,
-0.032619826,
-0.0040205675,
-0.020139663,
-0.00625682,
0.008610242,
0.030637998,
-0.0006561459,
0.0020387392,
-0.02426401,
0.03687808,
-0.007190824,
0.00003938759,
-0.015011013,
-0.006725496,
0.022670511,
-0.010699196,
-0.015265436,
0.007063612,
0.014823542,
0.0200861,
0.00056617695,
-0.008108089,
0.019296046,
0.0017558599,
-0.014033489,
-0.012627462,
-0.022161664,
0.0073983804,
0.0229785,
0.006193214,
-0.00043938344,
0.014729807,
-0.009420381,
0.0017709245,
0.023862287,
-0.024143493,
-0.007077003,
-0.000846127,
-0.016858933,
-0.0059387903,
-0.015171701,
-0.022884764,
-0.042421844,
-0.0033995726,
0.017260656,
-0.014796761,
0.0069698766,
0.027477786,
-0.022764247,
-0.016001927,
0.004867532,
0.011368733,
-0.018104272,
-0.006176476,
0.0071975193,
-0.02062173,
-0.01067911,
-0.030557655,
0.021867068,
-0.030611217,
0.0055471114,
0.000052961397,
-0.008516506,
-0.009099004,
-0.019055014,
0.009105699,
-0.028227666,
-0.010879971,
0.01861312,
0.0033342927,
-0.013290303,
-0.019429954,
0.014542337,
-0.008891447,
0.01030417,
0.024397917,
0.023232922,
0.005681019,
0.0051085646,
-0.004656628,
-0.025147798,
0.025870897,
-0.0026379745,
-0.012252521,
-0.0026396483,
0.023032062,
-0.02482642,
-0.010826408,
0.011683415,
0.0046666707,
-0.035324756,
-0.03050409,
-0.06706079,
-0.01158968,
-0.018385477,
-0.031173628,
-0.002991155,
-0.019389782,
0.0066987146,
-0.004315164,
-0.0013692025,
-0.011636548,
-0.04287713,
-0.00875754,
-0.019818285,
0.0016746786,
-0.026058368,
-0.006755625,
0.04598378,
-0.0059387903,
0.012781455,
0.025268314,
0.0014713069,
0.0084227715,
-0.009152566,
0.03636923,
-0.007251082,
-0.0071707377,
0.0052491673,
0.004197995,
-0.00784697,
-0.006852708,
-0.010498335,
-0.030798687,
0.00087625615,
0.000043519885,
0.0025141102,
-0.026125321,
-0.0037795345,
0.026366355,
0.0092864735,
0.047751356,
-0.028816858,
-0.06132956,
-0.0040573925,
0.01031756,
-0.009587766,
-0.0010972032,
-0.03286086,
0.00940699,
0.0071238703,
-0.019095186,
0.033128675,
0.009266388,
-0.01934961,
-0.0105452025,
-0.01898806,
0.025348658,
-0.012259217,
-0.028281229,
0.001406027,
-0.016149225,
0.01663129,
0.011803932,
0.001247849,
0.0014754914,
-0.0076528043,
0.0049110516,
-0.019965583,
0.0001329658,
-0.00008426747,
-0.015064575,
-0.049947437,
0.013055965,
0.0026195622,
-0.006923009,
-0.015238655,
0.0009591113,
-0.014395039,
0.00930656,
0.007679586,
-5.361524e-7,
-0.006608327,
-0.008637023,
-0.030745124,
0.02937927,
0.021318048,
0.0138728,
0.0051721707,
0.024598777,
0.006628413,
0.012955534,
0.007559069,
0.0111611765,
0.0048809224,
0.015278827,
0.010083223,
-0.010498335,
-0.0081281755,
-0.0032690128,
0.015934972,
0.02556291,
-0.0034112893,
-0.00088462536,
0.0038565313,
-0.02354091,
-0.00016905801,
0.022697294,
-0.039690133,
-0.039368756,
0.014488773,
-0.00040883583,
-0.0051453896,
-0.00021278713,
0.0036322365,
0.012259217,
0.0009917512,
-0.0027283619,
-0.008590155,
0.0008180901,
-0.0067422343,
0.021010062,
0.024022976,
0.026125321,
0.017662378,
0.012754674,
0.011911058,
0.013792455,
0.026245838,
-0.021612644,
-0.0053596413,
-0.02865617,
0.005396466,
-0.0072577777,
-0.027049283,
-0.022242008,
-0.01807749,
0.0047637536,
0.008000963,
0.021077015,
-0.0020872806,
0.089342974,
0.016550947,
-0.01664468,
0.0026095193,
-0.030048806,
0.017140139,
0.00721091,
0.008797712,
-0.016095662,
-0.018023927,
0.029807772,
-0.010505031,
0.03232523,
-0.035753258,
-0.026125321,
-0.0011198001,
0.0031384532,
0.03869922,
-0.030236276,
-0.00090973295,
0.02683503,
-0.0034481138,
0.009078917,
0.006638456,
-0.030396964,
0.029861337,
0.04539459,
-0.02171977,
0.0036088028,
-0.029780991,
-0.003595412,
0.008094698,
-0.02666095,
-0.0073314267,
-0.0091391755,
-0.020862764,
-0.0072376914,
0.00619991,
0.049786747,
0.02447826,
0.009192739,
-0.000049901406,
-0.013993316,
-0.024009585,
-0.0047302768,
-0.0028103802,
-0.031200409,
0.011375428,
-0.0109134475
] |
In patients presenting with idiopathic pulmonary fibrosis (IPF), modifications of pulmonary vessels are well defined in fibrotic areas but have not been accurately assessed in the intervening patches of preserved lung. Moreover, the relation between pulmonary vessel lesions and pulmonary hemodynamics is not well known. We therefore designed a retrospective study on lung explant specimens from 26 patients with a firm diagnosis of IPF who had undergone lung transplantation. Our aim was to (1) describe the vascular lesions, especially in preserved lung areas, and (2) correlate them with pulmonary hemodynamics. In dense fibrotic zones, thickening of the arterial and venous | [
-0.014997891,
-0.0050609624,
0.030867906,
-0.013716133,
-0.031528607,
0.014931821,
-0.027828686,
0.022833794,
-0.019992784,
0.0002426008,
-0.0029913196,
0.0060255844,
0.020798838,
0.013782203,
-0.0057613044,
-0.000050817125,
0.025093388,
-0.00784251,
-0.00050997786,
-0.022133453,
-0.0071091326,
0.023771988,
-0.007723584,
-0.0010538166,
-0.011767068,
0.00942819,
0.024749825,
-0.016411789,
0.0045456165,
-0.020666698,
0.00856928,
0.005222834,
-0.015737876,
-0.0017756314,
0.020745981,
0.0058273748,
-0.014918608,
0.015566094,
0.021512395,
-0.0048098965,
0.018116396,
0.0033926948,
-0.017046062,
-0.009144089,
-0.010855302,
-0.0075121596,
-0.0042483015,
-0.012460804,
-0.015671806,
0.013848273,
0.02737941,
-0.012295628,
-0.0028344032,
-0.0057877325,
0.000985269,
-0.011066726,
0.005368188,
0.025899442,
-0.009183731,
-0.02843653,
-0.00889963,
0.005685324,
-0.02064027,
0.0042549083,
-0.034752823,
0.010914765,
0.0031928332,
0.038003467,
0.019530294,
0.0128374025,
0.05359599,
0.024115553,
-0.02308486,
0.004264819,
0.03150218,
-0.010121925,
0.009527295,
-0.014918608,
-0.031660747,
0.016689284,
0.01575109,
-0.03892845,
-0.013557565,
0.031105759,
0.020944191,
-0.0034092122,
0.002135713,
0.008298392,
0.000380109,
0.0043011573,
0.012024741,
0.03242716,
0.0068448526,
0.0055102385,
-0.019226372,
-0.0034521578,
-0.0109081585,
0.016055012,
0.03163432,
-0.030101495,
-0.010571201,
0.009044983,
-0.028383674,
-0.016279649,
-0.018169252,
0.01055138,
0.0017425964,
0.0083578555,
0.030973619,
0.002333923,
0.0010083935,
0.030101495,
-0.008212502,
-0.0073535917,
0.013306499,
-0.00837107,
-0.00009471755,
0.0076509067,
-0.011291364,
-0.00626674,
0.023956984,
0.009791575,
0.017178202,
-0.008826952,
0.02275451,
-0.016623214,
-0.021446325,
0.005625861,
-0.003927862,
-0.0016055012,
-0.0008969003,
0.00863535,
0.016927136,
-0.021776674,
-0.012639192,
-0.03298215,
-0.028621526,
-0.024723396,
-0.032453585,
-0.0503982,
-0.009712291,
0.013636849,
-0.026877278,
-0.012784546,
-0.0110336915,
0.020164566,
0.02430055,
0.023362353,
0.013147932,
-0.018565672,
-0.0021703998,
-0.010875123,
-0.0152886,
-0.012632585,
-0.016319292,
-0.013121503,
0.012764725,
0.011245115,
-0.007882152,
-0.0013602163,
-0.014086125,
0.00097288087,
0.004958554,
0.0074857315,
0.016279649,
0.017653905,
0.003465372,
-0.021816317,
0.000076858,
-0.0016649641,
-0.015922872,
0.014641114,
-0.025185887,
0.023930557,
0.0073271636,
0.0057679117,
0.00073626766,
-0.0041425894,
-0.02949365,
-0.043077644,
-0.0108156605,
0.02202774,
0.024194837,
0.005368188,
-0.020138137,
-0.00086303946,
0.031290755,
-0.019358512,
-0.0030309616,
-0.04207338,
0.012123846,
0.027987255,
0.00018220869,
-0.009183731,
-0.6321578,
-0.028251534,
0.004998196,
-0.01786533,
0.019556722,
0.018750668,
0.008615529,
-0.015301813,
-0.015037534,
0.015090389,
-0.0043044607,
0.027617263,
0.00804072,
0.0018152734,
0.0060255844,
-0.025119817,
-0.03203074,
-0.010108711,
0.011331006,
-0.019094232,
0.0029698468,
0.032083593,
0.014535401,
0.036074225,
0.0152357435,
0.03070934,
0.033537135,
-0.006253526,
0.00956033,
0.018076753,
-0.03517567,
0.029414367,
-0.0028806522,
0.011317792,
0.047834683,
-0.0030375686,
-0.0055564875,
0.018539244,
0.012130453,
0.024393046,
-0.0003794896,
0.01476004,
0.033959985,
0.001163658,
-0.014707183,
0.037501335,
0.019926714,
-0.0056027365,
-0.005064266,
0.0009200248,
0.0018697812,
-0.0074064475,
-0.038690597,
0.021023476,
0.012209737,
-0.016491074,
0.017402839,
-0.019860644,
0.0062039737,
0.004456422,
0.008120004,
0.016253222,
-0.008926058,
-0.0045654373,
0.01938494,
0.02235809,
-0.0019936624,
0.004733916,
0.0073139495,
0.0014560177,
-0.0015262171,
0.051904596,
-0.00046166417,
-0.012176702,
0.026137294,
0.019821001,
0.005619254,
0.02711513,
-0.012632585,
-0.009639614,
-0.010306921,
0.015671806,
0.004297854,
0.0178389,
0.027696546,
0.016728926,
-0.03639136,
0.012229558,
-0.009058198,
0.019173516,
-0.00005791449,
-0.011152617,
-0.0077301906,
-0.033537135,
-0.017614264,
0.021485966,
-0.012969542,
0.015566094,
-0.0053780987,
-0.012804368,
-0.01654393,
-0.02149918,
0.015486809,
-0.014006841,
0.034197837,
0.025569092,
-0.03319357,
-0.011971885,
0.023692705,
-0.048442528,
0.016266435,
-0.025080174,
-0.0074196616,
-0.0144561175,
0.0067721754,
-0.032691438,
-0.004502671,
-0.008192681,
-0.0073932335,
-0.029097231,
0.02249023,
0.008608921,
0.0068250317,
-0.0050807833,
0.014218265,
-0.0051732813,
-0.0060387985,
-0.023996627,
-0.015024319,
0.0063096858,
-0.0006350979,
-0.007492339,
0.029202944,
-0.0048693595,
0.010141746,
-0.015500023,
0.0067325337,
0.012692048,
-0.007895365,
-0.05013392,
-0.00081761635,
-0.0064748605,
0.010372991,
-0.012454196,
-0.0024478938,
-0.009157303,
-0.0056093438,
0.0029566328,
-0.0037032238,
0.0028938663,
0.0021109367,
-0.027352983,
-0.010987442,
0.02817225,
0.008291786,
-0.004073216,
0.02711513,
-0.01684785,
-0.03295572,
-0.0014642765,
-0.0014337192,
0.004575348,
0.019199943,
0.0066268216,
0.0016682677,
-0.02665264,
-0.016702497,
-0.023600206,
-0.013716133,
-0.024168408,
0.0063625416,
0.0041690175,
-0.02235809,
0.0067721754,
-0.008073755,
-0.0023537439,
-0.008001078,
-0.02830439,
-0.015381098,
-0.0033233212,
-0.005421044,
-0.025793731,
0.029282227,
0.023494495,
0.014614685,
0.032242164,
0.030920763,
0.020917764,
-0.012929901,
0.034462117,
0.01601537,
0.017521765,
-0.01958315,
0.026665855,
-0.012824188,
0.013293285,
0.005876927,
-0.0008465219,
-0.00600246,
0.03906059,
0.034039266,
-0.031317182,
0.041782673,
0.0061907596,
0.024525186,
-0.016662855,
-0.0074659106,
-0.019741718,
0.03240073,
0.0077962605,
0.0012330315,
0.015843587,
-0.006517806,
-0.009467832,
-0.014852538,
0.019028163,
0.022609156,
-0.0027006115,
-0.016028583,
0.00316145,
-0.00685146,
0.01041924,
0.011793496,
0.019636005,
-0.02430055,
-0.0079217935,
0.006643339,
0.022992361,
0.002188569,
-0.031343613,
-0.0117802825,
0.018407105,
0.019873857,
0.018089967,
-0.004311068,
0.01700642,
0.004459725,
-0.0096330065,
0.029995782,
0.030762196,
0.027617263,
0.022847008,
0.01812961,
-0.010987442,
0.01002282,
0.0029384636,
0.021129187,
0.005328546,
-0.021129187,
-0.0015328241,
0.027696546,
0.012474017,
0.009930322,
-0.021512395,
0.0032605547,
0.002036608,
0.017812474,
0.023983411,
0.020587415,
0.0053979196,
0.022397732,
-0.0061577247,
-0.005229441,
-0.017323555,
0.02130097,
0.004459725,
-0.00214232,
-0.009910501,
-0.02420805,
0.014072912,
-0.012890258,
-0.009117661,
0.0070760977,
-0.029572934,
0.0318986,
-0.0038188463,
0.022595942,
0.0033233212,
0.018605314,
0.016319292,
-0.0012652406,
-0.018816737,
0.0093224775,
0.025621949,
-0.005553184,
-0.009130875,
-0.0059000514,
0.0038089359,
-0.017046062,
0.020587415,
0.018142823,
-0.015182887,
0.0028509207,
-0.0072809146,
0.018010683,
-0.00060784403,
0.023164144,
0.0004509278,
0.022040954,
-0.018618528,
-0.022516659,
0.008893023,
-0.016636427,
-0.013108289,
0.037131343,
0.0336957,
-0.00044019142,
-0.010366384,
0.004403566,
0.0090119485,
-0.008120004,
-0.013848273,
0.011377255,
0.0062502227,
-0.0091044465,
0.0012396385,
-0.017244272,
0.019821001,
0.031872172,
-0.009679256,
0.009388548,
-0.022582728,
-0.0028823041,
-0.02619015,
0.019477438,
0.010042641,
0.005328546,
0.018711025,
0.015526451,
-0.022001311,
-0.004489457,
-0.02817225,
0.022186307,
-0.010075676,
0.036708497,
-0.016411789,
0.016279649,
0.018896021,
-0.0034851928,
0.015275385,
-0.0025882926,
-0.025833372,
-0.0050741765,
-0.011859566,
-0.020983834,
-0.0023983412,
0.018499602,
0.030524343,
0.006537627,
0.01938494,
-0.0020200904,
-0.0068580667,
0.013676492,
-0.0032968933,
-0.041359823,
0.022860222,
-0.0011463147,
0.020230636,
-0.013471674,
-0.023732346,
0.016107868,
-0.024168408,
0.019067803,
0.012388126,
0.00009513048,
0.031052902,
0.018578885,
0.007736798,
0.005229441,
-0.012057777,
-0.01107994,
-0.0038485778,
0.0019044679,
-0.011304578,
0.027934399,
-0.0178389,
-0.019464225,
-0.03213645,
0.015196102,
0.0038122393,
0.03295572,
-0.0067787827,
0.006445129,
-0.0004311068,
-0.011694391,
-0.014601472,
-0.0061180824,
-0.012150275,
-0.013319713,
0.0010562942,
-0.017614264,
0.00126937,
-0.026731925,
-0.001322226,
-0.024326976,
0.014284335,
-0.022635585,
0.015050747,
0.0305772,
0.000035151308,
0.028859379,
-0.016002156,
0.022609156,
-0.006679678,
-0.009685863,
-0.010835481,
0.006273347,
-0.009249801,
-0.009124268,
0.009005342,
-0.03213645,
-0.010339956,
-0.0058207675,
0.010359777,
0.04648686,
-0.02328307,
-0.0016104564,
0.011331006,
0.021988098,
0.020270279,
0.022847008,
0.016821424,
-0.01786533,
-0.01978136,
0.015473596,
-0.02711513,
0.009487653,
-0.027617263,
0.005599433,
-0.0020415632,
-0.015196102,
-0.0147996815,
0.0070034205,
-0.0011083244,
0.028198678,
-0.011377255,
0.00856928,
0.011027084,
0.01872424,
0.019411368,
-0.024234477,
-0.0066367323,
0.026282648,
-0.0021984794,
-0.006669767,
0.000089659065,
0.029863643,
-0.011899208,
-0.030127922,
-0.0020432149,
0.017759617,
-0.03734277,
-0.033722132,
-0.0033282766,
-0.018882807,
0.044161193,
0.008404105,
-0.011912422,
-0.03361642,
-0.0070760977,
-0.0017392929,
-0.010934586,
-0.004459725,
0.010201209,
0.0067655686,
0.012705262,
0.005117122,
-0.00047570406,
0.03176646,
-0.03721063,
-0.015645377,
0.022794152,
-0.00087542756,
-0.00077632256,
-0.01760105,
0.0027716367,
-0.0025948994,
0.00929605,
-0.030894335,
-0.034329977,
-0.01575109,
-0.018499602,
0.014918608,
0.020072067,
0.016728926,
0.011588679,
0.012678835,
0.02202774,
-0.0018152734,
0.015526451,
-0.011575465,
-0.003782508,
-0.02315093,
0.032242164,
0.017680334,
-0.008086969,
0.017098919,
-0.01684785,
0.029202944,
0.020812051,
-0.028066538,
0.0057183593,
-0.003139977,
-0.031396467,
-0.0305772,
0.0008481737,
0.0059264796,
0.0012611112,
-0.037554193,
-0.0032506443,
-0.014099339,
-0.019728504,
0.0013015792,
-0.021538822,
0.02962579,
-0.0192528,
0.014099339,
0.0026791387,
0.015975727,
-0.00071107846,
-0.010439061,
-0.022067383,
-0.0010100452,
0.011443325,
-0.0033629632,
-0.008549459,
-0.0041359826,
-0.018076753,
0.0020002695,
-0.012824188,
-0.012487231,
-0.0021836136,
-0.003782508,
-0.0080142915,
-0.0073998407,
-0.011192259,
-0.020204209,
-0.025410524,
0.019266013,
0.01266562,
-0.011231901,
0.0074196616,
-0.02846296,
-0.006504592,
0.006943958,
-0.014323978,
0.0017392929,
-0.015143245,
0.039879855,
0.027220843,
-0.032215737,
-0.027722975,
-0.020613842,
-0.0035446559,
-0.0034323367,
0.0097585395,
-0.0012842357,
-0.022120237,
-0.026031582,
0.0071752025,
0.033510707,
-0.011535823,
-0.026467644,
0.019239586,
-0.011502788,
0.00028059105,
0.0013833408,
-0.018499602,
-0.042099807,
0.0075253737,
-0.017178202,
0.014865751,
0.008318214,
-0.0052459585,
-0.008932665,
0.011463146,
-0.004839628,
0.017574621,
-0.00850321,
-0.01680821,
-0.017019633,
0.011720819,
-0.021591678,
0.01542074,
0.00823893,
0.016292864,
-0.013689705,
0.0019589758,
0.008655171,
0.01376899,
-0.010894944,
-0.010518345,
0.00062105805,
0.042311233,
0.008800525,
0.00031858133,
0.01720463,
0.0066036973,
0.0102871,
-0.042496227,
0.011535823,
-0.037659902,
0.0083578555,
0.0075121596,
0.032347877,
0.0066730706,
-0.0044531184,
0.00891945,
-0.019873857,
-0.0062964717,
0.0028112787,
-0.018050326,
0.009461225,
-0.026494073,
-0.037792042,
0.010412633,
0.0040963404,
0.010875123,
0.009943536,
-0.008912844,
-0.011112975,
0.036444217,
-0.02116883,
0.015552879,
-0.0031647533,
-0.0003662756,
-0.031237898,
-0.000059101687,
-0.01892245,
-0.022807365,
-0.010954407,
0.0055829156,
-0.030603627,
-0.0035050139,
0.016464645,
0.013167752,
-0.012969542,
-0.029467223,
0.012718476,
0.0036999204,
0.0017838902,
-0.020521345,
0.0017558105,
0.031925026,
-0.008912844,
0.014376833,
0.009864252,
-0.027617263,
-0.008470175,
0.014337191,
-0.0112186875,
-0.0025701232,
-0.010320135,
-0.028198678,
-0.023758775,
0.032559298,
-0.04936751,
-0.020812051,
-0.0071289535,
-0.02209381,
-0.014099339,
-0.008523031,
0.021684175,
-0.017059276,
-0.011932244,
0.018089967,
0.005966122,
0.0073073427,
-0.02407591,
-0.003153191,
-0.012929901,
-0.017640691,
-0.016173938,
0.013689705,
-0.026361933,
0.059198726,
0.01978136,
0.0152886,
-0.024062697,
-0.005440865,
-0.079442576,
-0.01885638,
-0.0071355607,
0.024868751,
-0.009593365,
-0.01978136,
0.007195024,
0.018578885,
0.0028773488,
0.0072346656,
0.0033893913,
-0.036417786,
0.023851272,
-0.014244693,
0.025450166,
-0.014535401,
-0.030762196,
-0.034620684,
0.016292864,
0.011046905,
0.006101565,
0.021948457,
-0.0011644838,
0.0152886,
-0.016306078,
0.028515814,
-0.000767238,
-0.008985521,
0.004766951,
-0.02830439,
0.005705145,
-0.009342299,
0.009606579,
-0.013729347,
0.011225294,
0.026335504,
0.02817225,
-0.01002282,
0.017125346,
-0.011245115,
0.015473596,
-0.036999203,
0.0063724522,
-0.021221686,
-0.039853428,
0.030867906,
0.028383674,
0.005414437,
-0.012890258,
0.010716555,
0.0040038424,
-0.0148921795,
0.014205052,
-0.005117122,
0.012546694,
0.007584837,
0.0009902242,
-0.00810679,
-0.015275385,
-0.0051336396,
-0.015473596,
-0.0074526966,
0.034435686,
0.00096297037,
0.0063394173,
-0.015592521,
-0.00081472576,
-0.017283913,
-0.021525608,
-0.018803524,
0.0143636195,
-0.012282414,
0.011727426,
-0.013266858,
-0.0159493,
-0.010630664,
0.014284335,
-0.043183357,
-0.015063961,
0.026309077,
0.18277606,
-0.000766825,
0.0005211272,
-0.0034488544,
0.004357317,
0.004641418,
0.01753498,
0.007023242,
-0.018156039,
0.019398155,
0.007723584,
-0.013610422,
-0.018750668,
0.007426269,
0.02407591,
-0.0064087906,
-0.031132188,
-0.016583571,
-0.017706761,
0.008536245,
-0.012553302,
-0.015698234,
0.041095544,
0.013663277,
0.033008575,
-0.0037593835,
-0.002717129,
0.0042615156,
0.016226793,
0.019437796,
0.018935664,
-0.0067292303,
0.00035553923,
0.0073271636,
-0.006679678,
-0.01061745,
0.0003927036,
-0.009738719,
-0.0028823041,
-0.004529099,
0.008615529,
0.003736259,
-0.023190573,
0.0020382598,
-0.005883534,
0.023798415,
-0.0072148447,
-0.0111261895,
-0.014191837,
-0.011007263,
-0.023639848,
-0.0050675697,
0.013570779,
0.0305772,
-0.009269622,
-0.012810974,
0.027194414,
0.038584884,
-0.0020779017,
-0.0024363315,
-0.0050939973,
0.017693548,
-0.012454196,
0.017772831,
-0.009547116,
0.013306499,
-0.011800103,
-0.022913078,
-0.01154243,
0.0134914955,
0.02090455,
-0.019041376,
-0.0065574483,
0.018380675,
0.0029384636,
-0.023071647,
0.012890258,
-0.0013478281,
-0.004826414,
0.029414367,
0.003351401,
-0.009282836,
-0.044002622,
0.0061709387,
-0.020983834,
-0.030867906,
0.028489387,
0.011516002,
-0.02176346,
-0.021684175,
-0.0022166488,
-0.015566094,
-0.027022632,
0.006709409,
0.031105759,
0.010148353,
-0.0126524065,
0.0024545006,
-0.025939085,
0.024393046,
-0.013808631,
0.08176824,
0.016649641,
-0.009923715,
0.00031094198,
0.008813739,
-0.01661,
0.016464645,
-0.0070893117,
-0.0048165033,
0.010445668,
-0.025040532,
0.0035479593,
-0.020190993,
0.012883651,
0.03702563,
0.008423925,
-0.041703388,
0.00786233,
0.01259955,
-0.019834217,
-0.0059363903,
0.018142823,
0.0011231902,
-0.0035776908,
-0.0025899443,
-0.013650063,
0.021142403,
-0.018896021,
-0.020878121,
0.0015039186,
0.00040818876,
-0.004885877,
-0.017812474,
0.014112554,
0.0048429314,
-0.013418818,
-0.016385362,
0.0017888454,
0.021988098,
-0.00016992379,
0.009884073,
-0.0038915235,
0.03226859,
0.021922028,
0.02751155,
0.026282648,
-0.0053516706,
0.0066400357,
-0.005896748,
-0.017746404,
-0.026269434,
-0.0025503023,
-0.017019633,
0.026679069,
-0.033510707,
-0.0058934446,
-0.010082283,
-0.006412094,
-0.033114288,
-0.02665264,
0.028806522,
0.00942819,
-0.013022399,
-0.01180671,
-0.004998196,
-0.16501644,
0.023639848,
0.03322,
-0.0076971557,
0.017336769,
-0.014165409,
0.024366619,
-0.01912066,
-0.01872424,
-0.007895365,
0.020190993,
0.00936212,
-0.005493721,
-0.024115553,
-0.009778361,
0.020891337,
-0.007868938,
0.038214892,
0.026811209,
-0.009599972,
0.023335926,
-0.014376833,
0.01773319,
-0.028225107,
0.004297854,
-0.019464225,
-0.0039377725,
-0.008998735,
0.0018995127,
-0.004991589,
-0.000654506,
-0.0046050795,
0.04698899,
-0.004733916,
-0.0057877325,
0.00839089,
-0.017046062,
-0.013438639,
-0.009130875,
0.014654327,
0.029731503,
0.029890072,
0.002426421,
-0.010075676,
-0.0070628836,
0.01806354,
0.010313528,
-0.009950143,
0.035254955,
0.00029318564,
0.0055895224,
-0.009018556,
0.006402184,
0.013306499,
-0.008747669,
0.014535401,
-0.017178202,
0.0028178857,
0.016107868,
-0.0061709387,
-0.016900707,
0.00034748693,
-0.013253643,
0.018737454,
-0.0027468605,
-0.036470644,
-0.0021472753,
-0.017217843,
-0.015341455,
0.0070100278,
-0.02308486,
-0.04299836,
0.008443747,
-0.013035612,
0.05198388,
0.023256643,
-0.0041326787,
-0.0008465219,
-0.008893023,
0.0055697015,
-0.024379833,
0.022767724,
-0.004000539,
-0.024326976,
-0.004238391,
0.034462117,
0.00070983963,
-0.0074857315,
-0.004413476,
-0.017429268,
-0.0015212619,
-0.030365774,
0.020085283,
-0.008423925,
-0.00029504386,
0.043209784,
-0.0005368188,
-0.0016178893,
-0.014495759,
-0.0050675697,
0.02361342,
-0.011800103,
-0.000021124337,
0.010828874,
0.025106603,
0.0052063167,
-0.006425308,
0.013557565,
0.061630104,
-0.024868751,
-0.02414198,
-0.0022100417,
0.005533363,
0.012976149,
-0.000056933764,
0.010921372,
0.016385362,
-0.008285179,
0.012956329,
-0.033246428,
0.061841525,
0.0025172671,
0.012018134,
0.04553545,
0.0047966824,
-0.0027270396,
-0.13055433,
-0.014416476,
0.0070628836,
0.021657748,
0.023335926,
-0.0017458999,
0.00033695702,
0.0083578555,
0.008866595,
0.009646221,
-0.026560143,
-0.00087625347,
-0.00031176783,
-0.010610843,
0.02542374,
-0.006805211,
-0.008344642,
0.011271543,
-0.03573066,
0.029890072,
-0.011555644,
0.015063961,
-0.0042681224,
-0.010234244,
0.009765147,
-0.0052129235,
-0.018896021,
0.022265593,
0.004429994,
0.012896866,
0.006749051,
0.006359238,
0.0034620683,
0.008034113,
-0.009778361,
-0.010366384,
0.0022116934,
-0.011549037,
0.053437423,
-0.029255798,
0.011040298,
0.01898852,
0.030075068,
-0.005163371,
-0.00891945,
-0.016491074,
-0.045244742,
0.017389625,
0.009487653,
-0.017468909,
-0.024525186,
-0.021115974,
-0.00606853,
0.0053120283,
0.028753666,
-0.033378568,
-0.0014915304,
0.017019633,
-0.03374856,
-0.009249801,
-0.027564406,
-0.013002577,
-0.01945101,
0.0048132,
0.01694035,
-0.02936151,
-0.0006045406,
-0.014033269,
0.01279776,
-0.026943348,
-0.027300127,
-0.013663277,
-0.008086969,
-0.01015496,
-0.027485123,
-0.016028583,
-0.012289021,
-0.0013428729,
-0.00448285,
-0.011747248,
-0.014390048,
-0.0097585395,
0.032215737,
-0.02282058,
0.011297971,
0.04151839,
0.0049255188,
-0.026560143,
0.008959093,
-0.00068506337,
-0.0049750716,
0.014627899,
0.009111054,
-0.021552036,
0.007756619,
0.0083578555,
-0.018274963,
-0.002783199,
0.0064153974,
0.03440926,
-0.031132188,
-0.010848695,
-0.040699124,
0.016491074,
0.021274542,
0.010690127,
-0.011251722,
0.0027055668,
0.019041376,
0.010822267,
0.022384519,
-0.005467293,
-0.03295572,
0.025833372,
0.0024611077,
-0.0029714985,
-0.02103669,
-0.0011644838,
0.023732346,
0.01535467,
0.0094149755,
0.018605314,
0.004885877,
0.0122692,
-0.025251957,
0.00085065135,
-0.008338035,
-0.022794152,
-0.016240008,
0.013848273,
-0.0011826531,
-0.008331427,
-0.012275808,
-0.033272855,
-0.01678178,
0.012883651,
0.02024385,
-0.017032847,
-0.0069241365,
0.024591256,
0.005573005,
0.03144932,
-0.008172859,
-0.021908814,
0.0060387985,
0.0051666745,
-0.0011735685,
0.01312811,
-0.012097418,
0.018896021,
-0.0023917342,
-0.023032004,
0.018407105,
0.008853381,
-0.0018417015,
-0.020983834,
-0.033537135,
0.005784429,
0.013821845,
-0.0073998407,
0.001845005,
-0.020402418,
0.036708497,
-0.0054838103,
-0.0044399044,
-0.009950143,
-0.0021324095,
-0.02394377,
-0.0063889697,
0.015143245,
0.011093154,
-0.013623635,
-0.018565672,
-0.0076178717,
-0.006276651,
0.014984678,
0.02348128,
0.005929783,
-0.0050213207,
-0.001988707,
0.017217843,
0.002466063,
0.022001311,
-0.0047966824,
-0.034039266,
0.0011925636,
0.026877278,
-0.009058198,
-0.011568858,
0.04487475,
-0.0009604927,
0.0075451946,
-0.013478281,
0.009223373,
-0.013478281,
0.0016649641,
-0.010571201,
-0.010135139,
0.0032440373,
0.0037428658,
-0.0077632256,
0.02764369,
-0.006184153,
0.01707249,
0.007056277,
-0.004766951,
-0.029202944,
-0.0048032897,
-0.003201092,
-0.033959985,
-0.014508974,
0.011231901,
0.011397076,
-0.0011727426,
-0.007987863,
-0.010029427,
0.0023620026,
-0.0020663394,
-0.027881542,
0.003285331,
-0.0109081585,
0.026639426,
0.0043606204,
0.0051600677,
-0.0006578095,
0.020019213,
-0.014495759,
0.030920763,
0.0318986,
-0.02004564,
0.00639888,
0.0052525657,
0.014680755,
-0.0037065274,
-0.026903706,
-0.013141324,
-0.0053913123,
-0.01608144,
0.018896021,
0.02526517,
-0.0008085317,
0.08266679,
-0.016438218,
-0.017310342,
-0.002816234,
-0.03348428,
0.0042615156,
-0.0122163445,
-0.00044308198,
0.002287674,
-0.050821047,
0.0027683333,
0.0055102385,
0.019067803,
-0.025767302,
-0.04564116,
0.014852538,
-0.01141029,
0.0047768615,
-0.000707362,
-0.0017029544,
0.010135139,
-0.017217843,
0.014522187,
-0.0009249801,
-0.026916921,
0.011264936,
0.017482124,
-0.019239586,
-0.011727426,
-0.014152195,
-0.0038254533,
0.00501141,
-0.04920894,
-0.027855115,
0.008318214,
-0.010207816,
-0.0061544213,
-0.01614751,
-0.0071289535,
0.005097301,
-0.0038122393,
0.038135607,
0.0011099761,
-0.010987442,
-0.016358934,
-0.01912066,
-0.03731634,
-0.0048231105,
-0.0072941286
] |
Acute fatty liver of pregnancy (AFLP) and the syndrome of hemolysis, elevated liver enzyme levels, and low platelet count (HELLP) are rare but major disorders of the third trimester of pregnancy. Over a 10-year period, 46 women (median age, 30 years; range, 17-41 years) developed hepatic dysfunction severe enough to require transfer to our Liver Failure Unit. Three quarters of the women were nulliparous, and 5 had twin pregnancies; the median gestational age was 35 weeks (range, 24-40 weeks). At admission, 32 | [
-0.018356962,
-0.013367362,
0.02637738,
-0.04079031,
-0.03316694,
0.011236525,
-0.034887493,
0.013592358,
-0.028772917,
-0.00830497,
0.011322553,
0.011554166,
-0.0071336715,
0.019614289,
-0.0016221162,
0.019031947,
0.029037617,
0.0055156914,
0.00023905741,
0.0073255794,
-0.01769521,
-0.008563053,
-0.0030192372,
0.0046521067,
-0.008966721,
0.012282091,
0.017046696,
-0.030811109,
-0.0016204618,
-0.020871615,
0.016940815,
-0.008463791,
-0.0015724848,
0.0032607762,
0.0001688498,
-0.012804874,
0.0037686697,
0.0019141136,
0.0064355247,
0.0047248993,
0.029646428,
0.013751178,
-0.006283322,
0.029911129,
-0.008589523,
0.006068253,
0.005257609,
-0.019892223,
-0.03160521,
0.022618636,
0.010296839,
-0.003940725,
-0.0052741524,
-0.0089071635,
-0.0016154987,
0.02125543,
-0.020646619,
0.022592166,
0.0024137355,
-0.0059987693,
-0.014849684,
0.0059689907,
-0.01122329,
0.0037024948,
0.008443938,
0.028719977,
-0.005767157,
0.028852327,
-0.013618828,
-0.0014690864,
0.019428998,
0.021295134,
-0.0071866116,
-0.023664203,
0.020805439,
-0.0099064065,
-0.013565888,
-0.007947625,
-0.019601053,
0.012652672,
0.023545086,
0.0039605773,
-0.0055057653,
0.027846467,
0.0034080157,
-0.014876154,
-0.004546227,
0.036660984,
0.0073917545,
-0.0068027964,
-0.006339571,
0.0040002824,
0.025371518,
0.021692185,
0.0012689068,
-0.009370388,
0.006620815,
0.027872937,
-0.015365849,
-0.018502546,
-0.010885797,
0.015657019,
-0.023386266,
0.002658583,
-0.012652672,
0.0032425781,
-0.0076035145,
0.020209864,
-0.006174133,
-0.012037244,
0.009112306,
0.03157874,
0.036316875,
-0.038593296,
-0.0025113437,
-0.017959911,
0.003523822,
0.0030572878,
-0.027608236,
-0.015326144,
0.012149741,
0.019759873,
0.015723195,
-0.013274717,
-0.007464547,
0.018979007,
-0.021943651,
-0.01613348,
-0.0071601416,
0.003844771,
0.020527504,
0.0072461693,
0.03184344,
-0.01586878,
-0.035840414,
0.007980713,
-0.04182264,
-0.0320552,
-0.019468702,
-0.023095097,
0.006021931,
0.039546218,
-0.014704099,
-0.0006629914,
-0.019217238,
0.020712795,
0.022023061,
0.009509357,
-0.012030627,
-0.007087349,
-0.007358667,
0.0041160886,
0.015934955,
-0.0057142167,
0.0073123444,
0.012063714,
0.005055775,
-0.005558705,
-0.02138778,
-0.028746447,
-0.01345339,
-0.0065347874,
-0.00671346,
0.013579123,
-0.011984304,
0.014704099,
-0.014227638,
-0.01337398,
0.022724517,
-0.0069748517,
-0.012751934,
0.0040267524,
-0.006968234,
0.0037421999,
0.005297314,
0.018105498,
-0.02239364,
0.01756286,
-0.02616562,
-0.047196053,
-0.01753639,
0.03491396,
0.037587434,
0.0006696089,
-0.027978817,
0.014783509,
0.023677437,
-0.008536583,
0.0057340693,
-0.028534686,
-0.00087764673,
0.0069483817,
-0.00833144,
-0.015273204,
-0.64248043,
-0.010521835,
0.010475513,
0.014823214,
0.011468139,
0.007649837,
-0.011640193,
-0.0003596201,
-0.021837771,
0.014254108,
-0.008602758,
0.027793527,
-0.011554166,
0.0032723567,
0.0073388144,
0.0013822316,
-0.01552467,
-0.0033335688,
-0.007914538,
-0.016173186,
-0.028825857,
0.0032607762,
0.0010099969,
0.0104027195,
0.028111165,
0.036343344,
0.009582149,
-0.0026519657,
-0.009449799,
0.030334648,
0.010475513,
0.019971633,
-0.019243708,
0.02265834,
0.051484197,
-0.018131968,
-0.0029100482,
0.010276987,
0.020924555,
0.044760812,
-0.013711473,
-0.007398372,
0.019865753,
0.0064851562,
0.0031995643,
0.024325952,
0.012871049,
-0.0038249185,
0.0023839567,
0.010012287,
0.0069616167,
0.0134798605,
-0.0072594043,
0.014876154,
-0.019230474,
-0.008966721,
0.018423136,
-0.005485913,
-0.0047414433,
-0.013440155,
-0.0030258547,
0.0063461885,
-0.011865188,
-0.011190203,
-0.0023558321,
-0.0026701638,
-0.0015542868,
0.021348074,
-0.0039274897,
-0.0006332126,
0.022155412,
0.037322734,
-0.005078936,
-0.0113027,
0.023306856,
-0.0056050275,
0.027608236,
0.026152384,
-0.006696916,
0.007398372,
0.011812248,
-0.0028041683,
-0.017893737,
0.010713742,
0.028296456,
-0.0048936456,
-0.015299674,
0.01302987,
-0.006968234,
-0.017390806,
0.0074049896,
-0.0042682914,
-0.010554923,
-0.021109845,
-0.012321796,
0.01114388,
-0.03316694,
0.0034741908,
0.02014369,
-0.017840797,
-0.008596141,
-0.017112872,
0.014624689,
-0.0019091505,
0.030599348,
0.018423136,
-0.030652288,
0.0015484964,
0.03306106,
0.002698288,
0.0044403467,
0.006299866,
-0.013711473,
-0.018515782,
0.036105115,
-0.018661367,
-0.024206838,
0.010177724,
-0.02088485,
-0.018886363,
0.04079031,
0.018277552,
0.03165815,
0.019164298,
-0.020898085,
0.010217429,
0.0024600578,
-0.0030639053,
0.0007270985,
-0.0033583844,
0.019468702,
0.010025522,
0.027158245,
-0.018952537,
0.017470216,
-0.0051517286,
0.017986381,
-0.007179994,
0.013936468,
-0.03441103,
-0.028164105,
-0.008721873,
-0.014148228,
0.006591036,
0.002754537,
-0.027025895,
0.0046918117,
-0.0032938637,
0.0037686697,
0.0065744924,
-0.017655507,
0.011090941,
-0.0062403083,
0.02268481,
-0.017854031,
-0.0058333315,
0.00814615,
-0.038540356,
-0.0014657776,
-0.02497447,
0.010753447,
0.024789179,
-0.009496122,
0.009873319,
0.002266496,
-0.027502356,
-0.000060333045,
-0.012579879,
-0.010786535,
0.0076829246,
-0.0134930955,
-0.026761195,
-0.015365849,
0.010601245,
-0.026933251,
0.014505574,
0.013340892,
-0.02027604,
-0.01578937,
0.010442425,
0.010078462,
0.0016370056,
0.0066671376,
0.009304213,
0.0160276,
0.014148228,
0.0014930748,
0.021559834,
-0.005614954,
0.030096417,
-0.013301187,
0.022923041,
-0.023333326,
0.016014365,
-0.0124739995,
0.014187933,
-0.021506894,
-0.008582906,
-0.021970121,
0.03303459,
0.046296075,
-0.01631877,
0.018449606,
-0.01586878,
0.03409339,
-0.021903945,
-0.004238513,
-0.009826996,
0.008940251,
-0.003049016,
-0.025821509,
-0.0010571466,
-0.011051236,
-0.018356962,
-0.004264983,
-0.002469984,
0.009522592,
-0.0134798605,
0.0042947615,
-0.014836449,
0.011335788,
-0.020236334,
0.025345048,
0.028693506,
0.0020911319,
-0.0036495547,
-0.000058523572,
0.008774813,
-0.0050987885,
-0.017152576,
0.0006778808,
-0.0073652845,
-0.0041193976,
0.02265834,
0.0059524467,
0.01074683,
0.022923041,
-0.026364144,
0.026417084,
0.0033732739,
0.0018181598,
0.011891658,
0.04100207,
-0.0017073166,
-0.0056579676,
-0.011560784,
0.010806387,
0.009866701,
-0.02658914,
0.009879936,
0.00048349155,
0.035258073,
-0.024934763,
0.0049697473,
-0.005588484,
0.004248439,
-0.00020079996,
-0.017523156,
0.012619584,
0.021162786,
0.026099445,
0.003765361,
-0.019217238,
-0.025596514,
0.0105086,
-0.0042021163,
0.0059028156,
0.0018131967,
-0.005297314,
0.018462842,
-0.03123463,
-0.012791639,
0.013221777,
-0.017417276,
0.023743613,
0.0108990325,
0.02685384,
0.0027694264,
0.03168462,
-0.009602002,
-0.014015879,
-0.04248439,
0.01642465,
0.03157874,
-0.021612775,
-0.01748345,
-0.0034940434,
0.006068253,
0.016040836,
0.0071601416,
-0.006250235,
0.012904137,
0.0022168646,
0.014174698,
0.0020861689,
-0.008920399,
0.021242196,
-0.012560027,
0.016702585,
-0.017827561,
-0.004420494,
-0.016570235,
-0.0113027,
0.011812248,
0.017840797,
0.017073166,
-0.0105086,
-0.02709207,
-0.002324399,
0.009456417,
0.011574019,
-0.016014365,
0.004645489,
0.013155602,
0.003993665,
0.012149741,
0.0021804683,
0.021189256,
0.020156924,
-0.022486286,
-0.0031069191,
-0.012818109,
-0.018012851,
-0.010012287,
0.04079031,
0.031366978,
0.024762709,
0.01581584,
0.016874641,
-0.013201925,
0.015154089,
-0.03165815,
0.02120249,
0.024868589,
-0.0009454762,
-0.027184715,
0.017020226,
0.0000703627,
0.008933634,
0.0051748897,
0.0040962365,
-0.035363954,
0.003983739,
-0.015683489,
0.0015352614,
-0.0036958773,
0.02109661,
0.04012856,
-0.004585932,
-0.018859893,
0.008913781,
0.020659855,
-0.0035668358,
0.02091132,
-0.012368119,
0.003062251,
-0.019336352,
0.03517866,
0.008933634,
0.0072991094,
0.01003214,
-0.034755144,
0.040922657,
0.02223482,
0.01321516,
0.01621289,
0.00830497,
0.0020894776,
0.01592172,
-0.004619019,
-0.01993193,
0.024378892,
0.0025179612,
-0.019256944,
0.055957634,
0.03539042,
-0.0035866883,
-0.009760821,
0.008390998,
-0.0053039314,
0.003818301,
-0.015299674,
0.020156924,
-0.015326144,
0.015299674,
-0.019667229,
-0.0004578487,
0.009019661,
-0.014214403,
-0.0034510295,
-0.018423136,
-0.020553974,
-0.037905075,
0.0068027964,
-0.0017139341,
-0.0108990325,
-0.011487991,
-0.004572697,
-0.007034409,
0.0012771786,
-0.01297693,
-0.013155602,
0.035496302,
0.02497447,
-0.0034609558,
-0.0109321205,
0.0050623924,
-0.026099445,
-0.011018148,
-0.005737378,
0.004304688,
-0.035416894,
-0.005853184,
0.0047282083,
0.0055553964,
-0.014015879,
-0.009628472,
0.007980713,
-0.007371902,
-0.0030010391,
0.0109122675,
0.03216108,
-0.009747586,
0.00011218741,
-0.010601245,
-0.03986386,
-0.018065792,
-0.02096426,
-0.027740587,
-0.00658111,
-0.008920399,
-0.007993948,
-0.015140854,
-0.027184715,
0.018621663,
0.010323309,
-0.009965965,
0.0134798605,
0.023267152,
0.033643402,
-0.00528077,
0.010296839,
0.03382869,
-0.009800526,
-0.018383432,
-0.0144923385,
0.032716952,
0.006981469,
-0.009410094,
0.026099445,
0.019495172,
-0.021692185,
-0.04293438,
-0.013843823,
0.011150498,
0.041346177,
-0.011216673,
-0.023571556,
-0.047831334,
0.0033517668,
-0.030228768,
0.0059590642,
-0.003738891,
-0.019309884,
0.0033798914,
0.011163733,
-0.010832857,
-0.027012661,
0.027661176,
-0.030943459,
0.005588484,
0.014836449,
-0.038593296,
0.015405554,
0.0060748705,
-0.0026205324,
-0.01660994,
0.003699186,
-0.013201925,
-0.013671768,
0.011851953,
-0.019111358,
0.023161272,
0.01597466,
0.025556808,
-0.00030026934,
0.028825857,
-0.0012655981,
-0.006366041,
0.013962938,
-0.018714307,
0.012533557,
-0.0016072268,
0.023518616,
0.014849684,
0.009377006,
-0.0015178905,
-0.024617122,
0.032716952,
0.04219322,
-0.027396476,
-0.033749282,
-0.0018181598,
-0.01766874,
-0.015657019,
-0.008139533,
-0.0075373393,
0.0016138443,
-0.039096225,
-0.012698994,
-0.009582149,
0.0014492339,
-0.008999809,
-0.02107014,
0.03165815,
-0.014214403,
0.029964069,
0.00014020842,
0.011865188,
-0.0005260917,
-0.023055391,
0.0054561337,
-0.008516731,
-0.0026602375,
0.017377572,
0.028640566,
0.0013367363,
-0.011567401,
-0.009224803,
0.013221777,
-0.03194932,
0.0023062008,
-0.002833947,
-0.025186228,
0.0042021163,
-0.006822649,
0.011388728,
-0.034596324,
-0.018449606,
-0.007788805,
-0.008748343,
0.024193602,
-0.012083566,
0.0019918694,
-0.008510113,
0.0047149733,
0.004559462,
-0.011176968,
0.03218755,
0.02138778,
0.012831344,
-0.02130837,
-0.016702585,
0.027555296,
0.002762809,
0.027555296,
0.010594628,
-0.018674603,
-0.0054296637,
0.010210812,
0.028693506,
-0.025847979,
-0.049207777,
0.027740587,
0.002921629,
-0.020315744,
-0.00044792244,
-0.0048407055,
-0.021798065,
0.011812248,
-0.0012474,
0.008113063,
-0.0019405837,
-0.017787857,
-0.005452825,
0.02133484,
-0.030678758,
0.015259969,
0.008437321,
0.009668176,
0.011216673,
-0.04452258,
-0.0061178845,
0.004595858,
0.007424842,
0.024524478,
0.0024054635,
0.010310074,
0.0007279257,
-0.0039142547,
-0.0009520937,
-0.007848362,
-0.011415198,
0.025728865,
0.00044254572,
-0.0044866693,
0.048148975,
0.010171107,
0.010574775,
-0.018065792,
0.0010497019,
-0.026072975,
-0.020448094,
0.004341084,
0.018489312,
-0.00049796735,
-0.018727543,
0.0067465478,
-0.027634706,
-0.002210247,
-0.028508216,
-0.039202105,
0.020289274,
-0.037719786,
-0.014677629,
-0.0045263744,
-0.0134798605,
-0.006313101,
-0.010687272,
-0.009304213,
-0.011494609,
0.011719603,
-0.022023061,
0.015154089,
-0.0210172,
0.018158438,
-0.0268009,
0.00084869517,
-0.03382869,
-0.0060252394,
-0.0076432195,
-0.0088740755,
-0.022803927,
-0.0047943834,
0.022870101,
0.014743804,
-0.0021341457,
-0.017761387,
0.03303459,
0.008794665,
0.011210055,
-0.017470216,
-0.006756474,
0.029275848,
-0.0063991286,
0.013857058,
-0.0024799104,
0.0077689523,
-0.00541312,
-0.01297693,
-0.012493852,
-0.017311396,
-0.009158629,
-0.008410851,
0.01653053,
0.013016635,
-0.037322734,
0.0042550564,
-0.020514268,
-0.0077557173,
0.0019687081,
0.012004157,
0.007636602,
-0.0017453673,
-0.0066108885,
0.0099064065,
0.012030627,
0.024511242,
0.0070807314,
0.007034409,
-0.006021931,
0.0036396284,
-0.023730377,
0.015034974,
-0.018992243,
0.029699368,
0.012308561,
-0.028084695,
-0.017073166,
0.019124594,
-0.004810927,
-0.0016245978,
0.000018262766,
0.015048209,
0.022208352,
0.011084323,
-0.0044138767,
0.02688031,
-0.005158346,
0.006902059,
-0.040366787,
-0.018158438,
0.009079219,
-0.014161463,
0.03501984,
-0.012520322,
-0.04272262,
-0.0119379815,
0.024828883,
0.013380597,
-0.017284926,
0.007894685,
-0.00018715135,
0.010184342,
-0.011269613,
0.0076961596,
-0.011104176,
-0.011071088,
0.007127054,
-0.014757039,
0.00780204,
-0.006160898,
0.019706933,
-0.015273204,
-0.00044626807,
0.0212819,
-0.020183394,
-0.012381354,
-0.01653053,
-0.012050479,
0.0065083173,
-0.0034774996,
0.008218942,
-0.0023574866,
-0.014439398,
-0.006835884,
0.027793527,
0.001292068,
0.026814135,
0.0012242387,
-0.010938738,
-0.012533557,
0.0047282083,
0.004801001,
-0.027528826,
0.0017718372,
-0.02109661,
-0.017351102,
-0.01613348,
-0.01111741,
-0.02664208,
-0.03242578,
0.03486102,
-0.0076432195,
0.0042418214,
-0.023968607,
0.015273204,
-0.014015879,
0.010184342,
-0.0032127993,
0.013301187,
-0.008390998,
-0.010548305,
-0.0051384936,
-0.022803927,
-0.0052179038,
0.004344393,
-0.014359988,
0.00036396284,
0.023465676,
0.18465489,
-0.007424842,
0.0021358002,
0.003168131,
-0.0078880675,
0.0025990256,
0.03245225,
0.0014905933,
-0.013367362,
0.0022499522,
0.02144072,
-0.012758552,
-0.02608621,
0.008814518,
-0.007279257,
-0.009515974,
-0.035152193,
-0.008563053,
-0.023359796,
-0.00652817,
0.009489504,
-0.008450556,
0.0033550756,
-0.0049465857,
0.039519746,
0.0047381343,
-0.0063958196,
0.027952347,
0.016954051,
0.0052377563,
0.007305727,
-0.024299482,
-0.014942329,
0.00541312,
0.0076829246,
-0.011110793,
0.005509074,
-0.008132915,
-0.014082053,
-0.00053932675,
-0.027370006,
0.027184715,
-0.008635846,
-0.01987899,
-0.012249004,
0.0176158,
0.0066671376,
-0.028137635,
-0.016901111,
-0.010442425,
-0.03247872,
0.0023756847,
0.01090565,
0.023875963,
0.011057853,
0.020183394,
0.0057969354,
0.020553974,
-0.0077689523,
0.020633385,
0.0067465478,
0.01586878,
-0.014757039,
0.0052079773,
-0.010018905,
0.03165815,
-0.0003947756,
-0.018423136,
-0.012288709,
-0.008324822,
0.0000063331604,
-0.024736239,
-0.029408198,
-0.00024195257,
-0.014902624,
-0.018939303,
0.025847979,
0.014386458,
-0.013843823,
0.020752499,
-0.0034080157,
-0.0129570775,
-0.0320552,
-0.002297929,
-0.013122515,
-0.037428614,
0.024352422,
0.022671577,
-0.034649264,
-0.011104176,
-0.002061353,
-0.019190768,
-0.0045230654,
-0.0034013982,
0.014439398,
0.018145202,
-0.0067730173,
0.0022135559,
-0.016199656,
-0.0260068,
-0.0071998467,
0.048757784,
-0.008986574,
0.014571749,
-0.019442232,
0.0028058225,
-0.03237284,
-0.002074588,
0.007815274,
-0.017165812,
0.0037885222,
-0.0021490352,
0.005856493,
-0.022023061,
0.003831536,
0.024828883,
0.02672149,
-0.012685759,
0.0073785195,
-0.014148228,
-0.004685194,
-0.013367362,
0.048254855,
0.0004009795,
-0.0067300037,
-0.019786343,
-0.028375866,
-0.009112306,
-0.020646619,
-0.01132917,
0.0040796925,
-0.019124594,
0.008033653,
-0.005585175,
-0.0037223473,
-0.020818675,
-0.0140026435,
0.00403337,
-0.0011828792,
0.02003781,
0.0020729338,
-0.0041425587,
0.009211568,
-0.008443938,
-0.002996076,
-0.019124594,
0.034172803,
0.0034411033,
-0.058710515,
0.000038128208,
-0.019442232,
-0.033802222,
-0.018912833,
0.004774531,
0.044363763,
-0.04266968,
-0.019177534,
-0.005707599,
0.0063594235,
0.009085836,
-0.028984677,
0.0328493,
0.015246734,
-0.008311587,
-0.0031350437,
0.005025996,
-0.16718468,
0.0076299845,
0.0020812056,
-0.012421059,
0.030784639,
-0.0018264317,
0.02635091,
0.01302987,
-0.019243708,
-0.015657019,
0.026814135,
-0.014757039,
-0.022076001,
-0.02159954,
-0.0025957169,
-0.0014128375,
-0.010985061,
0.038355067,
0.028402336,
0.0057274518,
0.030837579,
-0.024577418,
0.0088079,
-0.013261482,
0.0025295417,
0.02003781,
-0.011342405,
-0.012811492,
-0.0071998467,
-0.006098032,
-0.02252599,
0.012877667,
0.0040002824,
0.012837962,
-0.0031797118,
-0.025464164,
-0.0041293236,
-0.020289274,
0.0017635653,
0.038540356,
0.00026428665,
0.013235012,
0.0021937033,
0.021189256,
0.006177442,
0.048731316,
-0.0005844085,
-0.012004157,
0.038778584,
-0.005485913,
-0.0015418789,
-0.029619958,
0.024842119,
0.019548113,
-0.0026288044,
0.0031615135,
-0.015736429,
0.0034080157,
0.0124739995,
-0.017006991,
-0.017298162,
-0.019706933,
0.006021931,
0.009085836,
0.038302127,
-0.012004157,
-0.01645112,
0.025821509,
-0.025133288,
0.0026172237,
-0.0047116643,
-0.049975406,
-0.0047282083,
-0.030625818,
0.044310823,
-0.0032971725,
-0.03425221,
0.038116835,
0.01345339,
-0.015987895,
-0.016384946,
0.023452442,
-0.025847979,
-0.022248056,
-0.03218755,
-0.001190324,
-0.011785778,
0.020315744,
-0.019349588,
-0.022406876,
0.025477398,
-0.030705228,
-0.012282091,
-0.020103984,
-0.0088873105,
0.024736239,
-0.01613348,
0.011679898,
-0.0063858936,
-0.00051078876,
0.030387588,
0.0012837962,
-0.032611072,
0.01671582,
0.021877475,
-0.0052741524,
-0.032558132,
-0.00020596987,
0.051007736,
-0.027343536,
-0.00886084,
0.013512948,
0.011461521,
0.016729055,
-0.0017784548,
0.018304022,
0.01745698,
-0.0007502598,
0.029222907,
-0.019455468,
0.04338437,
0.0026288044,
-0.011130645,
0.034119863,
0.0093836235,
0.03393457,
-0.11530343,
-0.03118169,
-0.01608054,
0.02688031,
0.018290788,
0.011984304,
0.0037719784,
0.006326336,
-0.0024087722,
0.027528826,
-0.016146716,
0.001480667,
-0.020434858,
-0.020659855,
0.060457535,
-0.002890196,
-0.0011655083,
-0.0124541465,
-0.03155227,
0.049869526,
-0.008642463,
-0.008132915,
0.019759873,
-0.015683489,
-0.006915294,
-0.01626583,
-0.008563053,
0.007788805,
-0.00559841,
0.008715255,
0.0050855535,
-0.0060120043,
0.009529209,
0.0038282273,
-0.008840988,
-0.03115522,
-0.008344675,
0.00053270924,
0.0109321205,
-0.018237848,
0.014704099,
0.0052212123,
0.01650406,
0.0017900354,
0.027184715,
-0.008000565,
-0.04182264,
0.009052749,
0.028058225,
-0.0072858743,
-0.01584231,
-0.032769892,
-0.0020663163,
-0.0006290767,
0.0154849645,
-0.031022869,
0.02690678,
0.016940815,
-0.03163168,
0.010985061,
-0.0019141136,
-0.006902059,
-0.010654185,
0.013685003,
0.024537712,
-0.018992243,
-0.015193794,
-0.014068818,
0.010687272,
-0.026655314,
-0.022433346,
0.011315935,
0.0018859892,
-0.0124739995,
-0.0069748517,
0.030731698,
-0.004274909,
0.0020315745,
-0.0039142547,
-0.0036826422,
-0.009125541,
-0.011448286,
-0.0029596796,
0.013896763,
0.023889197,
0.024220072,
0.008477026,
-0.0049201157,
-0.008986574,
-0.006782944,
0.008086593,
0.015207029,
0.026364144,
-0.013413685,
-0.029196437,
0.0051616547,
-0.01337398,
-0.011494609,
0.04174323,
0.026522964,
-0.02276422,
-0.018740777,
-0.05000188,
0.016384946,
0.010310074,
0.00068243034,
-0.007179994,
0.0053138575,
-0.006389202,
-0.0002686294,
0.013830588,
0.0026238412,
-0.028349396,
0.013221777,
-0.02165248,
-0.010938738,
-0.023055391,
0.010038757,
0.022128941,
0.03208167,
0.036184523,
0.019124594,
-0.011157115,
0.0008950177,
-0.014783509,
0.011699751,
0.006564566,
0.005065701,
0.019521642,
0.016557,
-0.0070807314,
0.0034278682,
-0.003910946,
-0.026390614,
-0.007557192,
0.010336544,
-0.010071845,
-0.039890327,
0.012659289,
-0.001647759,
0.023412736,
0.02257893,
0.0021093301,
-0.009290978,
0.016411416,
-0.001915768,
0.0054792953,
-0.009105689,
0.007438077,
0.011693133,
0.016120246,
0.013499713,
0.036237463,
0.0114218155,
0.0021093301,
-0.012149741,
-0.047222525,
0.014902624,
-0.018793717,
-0.018370196,
-0.008715255,
-0.015617315,
0.030149357,
-0.003017583,
0.0154981995,
-0.010025522,
0.011031383,
-0.006375967,
-0.005978917,
0.002486528,
0.020540738,
-0.028852327,
-0.0083777625,
0.005495839,
-0.008086593,
0.02170542,
0.024696533,
0.00995273,
-0.010449043,
0.039599158,
-0.01008508,
0.011282848,
0.013254865,
0.004049914,
-0.029328788,
0.01064095,
0.024206838,
-0.010998296,
-0.010488748,
0.027475886,
-0.0053800326,
0.020924555,
-0.016517295,
0.018833423,
-0.012176211,
0.010323309,
0.0053403275,
-0.012196064,
0.0023889197,
0.0032343061,
0.007894685,
0.009224803,
-0.011574019,
-0.0029431358,
0.0065083173,
0.010634332,
0.0010563195,
-0.016146716,
-0.013685003,
-0.048916604,
0.008748343,
-0.014982034,
0.017139342,
0.0023558321,
-0.010607863,
0.0036958773,
-0.021903945,
-0.0066902987,
-0.01756286,
0.028349396,
-0.006928529,
0.016676115,
0.0067333127,
0.018912833,
-0.0008751652,
-0.014346753,
0.027714116,
-0.0031863293,
0.037269793,
-0.014598219,
-0.004489978,
-0.0012837962,
-0.0011837065,
-0.0048804106,
-0.040155027,
-0.012712229,
0.010283604,
-0.0032260343,
0.012480617,
0.0035006609,
0.024445068,
0.07607485,
-0.010098315,
-0.034622792,
0.015696725,
0.004288144,
0.016199656,
-0.0019091505,
0.0048407055,
0.008390998,
-0.0048307795,
0.02658914,
-0.025424458,
0.0031118824,
-0.045025513,
-0.008463791,
-0.018727543,
0.009178481,
-0.00790792,
-0.005694364,
-0.00032094904,
0.011607106,
-0.011792396,
0.0057274518,
0.03210814,
-0.025715629,
-0.0022284451,
0.0520136,
-0.005171581,
0.0053634886,
-0.021506894,
-0.0011150498,
-0.005373415,
-0.025517104,
-0.017126106,
0.026390614,
-0.025014173,
-0.029514078,
-0.0041591027,
0.024775943,
0.023809787,
-0.019561348,
0.0032012186,
-0.015934955,
-0.012202681,
-0.017205516,
-0.034066923,
-0.0073520495,
0.0009951075,
-0.023756847
] |
Circadian oscillators play an indispensable role in the coordination of physiological processes with the cyclic changes in the physical environment. A significant number of recent clinical and molecular studies suggest that circadian biology may play an important role in the regulation of adipose and other metabolic tissue functions. In this discussion, we present the hypothesis that circadian dysfunction may be involved in the pathogenesis of obesity, type 2 diabetes, and the metabolic syndrome. | [
-0.025018035,
-0.008709059,
0.018008785,
-0.008164332,
-0.0308197,
0.013690352,
-0.004124826,
0.013158752,
-0.012988115,
0.005401323,
0.018428816,
0.0028105911,
0.016446799,
0.0022051574,
-0.016617436,
0.0033126583,
0.040821664,
-0.012423699,
0.0014971772,
0.011944602,
-0.035492532,
0.012312128,
-0.005985427,
-0.012246499,
0.0018212238,
0.017706888,
0.0034947807,
-0.036752623,
0.012679655,
-0.024952406,
0.02535931,
-0.0062184124,
-0.015934886,
0.006044494,
0.01092078,
-0.026159992,
0.0016489459,
-0.0148323085,
0.0011641065,
-0.02332479,
0.020213943,
0.007921503,
-0.0066121905,
-0.0006907524,
-0.023101648,
0.020371454,
0.040506642,
-0.025753088,
0.003977159,
0.023101648,
0.00044628186,
0.023600435,
-0.025595577,
-0.01731311,
0.004101855,
0.003632603,
0.008059325,
0.01505545,
0.002226487,
-0.04848721,
0.0026957393,
-0.024545502,
-0.013677226,
0.0012814195,
0.0024020465,
-0.012141491,
0.004101855,
0.029769624,
0.0136641,
0.026960675,
0.041215442,
0.028824557,
-0.010664823,
0.018310681,
0.015948012,
-0.015081701,
-0.023285411,
0.010100408,
0.008124955,
0.0028466876,
-0.0019065423,
-0.022051573,
0.0034947807,
0.039351556,
-0.0016505865,
0.00095081003,
-0.0077836807,
-0.0026826132,
-0.006572813,
0.011176735,
0.0046728333,
0.012390885,
0.023613561,
0.0077508655,
-0.023954835,
0.02858829,
0.011590202,
0.027774483,
-0.0061659086,
-0.011006098,
0.0016981681,
0.029979639,
-0.025687458,
-0.01863883,
-0.040690403,
-0.013145626,
0.009122526,
-0.0024857242,
0.01925575,
-0.025018035,
-0.022720996,
0.04622955,
-0.0009770619,
-0.034967497,
-0.011071728,
-0.0012174306,
0.004472663,
0.012259625,
-0.0089322,
-0.02503116,
0.022760374,
0.023075396,
0.009542556,
-0.015160457,
0.003665418,
-0.0059001087,
0.0028352023,
-0.0009696786,
-0.014937316,
-0.013585345,
-0.041740477,
0.0050731744,
-0.0022100797,
0.021736551,
-0.03612258,
0.0033060953,
-0.0103038605,
0.0029172394,
-0.018455068,
0.0031403804,
0.0015144049,
0.027984496,
-0.046177045,
-0.0059690196,
0.0036686994,
0.048592217,
0.019820165,
0.020843988,
-0.0021707017,
0.00623482,
0.02109338,
0.0031403804,
0.0135065885,
0.0074161543,
0.023626685,
0.015948012,
0.0021034314,
0.019728282,
-0.015147331,
-0.024808021,
0.0077771177,
-0.013073433,
0.0032092915,
0.022235338,
0.021172136,
-0.006359516,
0.0048762853,
-0.015370472,
0.010566379,
-0.0035932253,
-0.013040618,
0.01492419,
-0.006198724,
0.040454138,
-0.007028939,
0.023521679,
-0.011524572,
0.010395742,
-0.01443853,
-0.023167279,
-0.029953387,
0.007678673,
0.017943155,
0.007855874,
-0.021789055,
-0.00021965435,
0.015291716,
0.009522867,
0.025149295,
-0.027223192,
-0.0153967235,
0.0035899437,
-0.002511976,
-0.012088988,
-0.64768624,
-0.0028712987,
-0.0036851068,
-0.03352364,
-0.012075862,
0.010264482,
0.006602346,
0.012121802,
0.0048631597,
0.0021149165,
-0.004498915,
0.007862436,
0.00083390716,
-0.028089505,
-0.006825487,
-0.037041392,
0.008610615,
-0.021408403,
0.0046728333,
-0.0067073535,
-0.00404607,
0.0064678052,
0.0022281278,
0.0073177097,
0.00994946,
0.017562503,
0.023285411,
-0.003517751,
-0.00059887086,
0.0371464,
-0.00023995854,
0.01660431,
-0.006126531,
-0.003296251,
0.047122113,
-0.009004393,
-0.01779877,
0.023416672,
-0.0066482867,
0.04596703,
-0.016026769,
-0.01773314,
0.037356418,
0.021592166,
-0.023403546,
0.018560074,
0.007284895,
-0.006343109,
-0.00539476,
-0.022931011,
0.014464783,
0.004594078,
-0.0151998345,
-0.017549377,
0.016276162,
-0.023377294,
0.030425921,
-0.027301949,
0.008564673,
0.021395277,
0.015501731,
0.017431244,
-0.019282,
-0.011025786,
-0.0069173686,
0.042370524,
-0.028982067,
0.009483489,
0.0053422563,
-0.0112358015,
0.016840577,
0.038485248,
0.00025144374,
0.022366596,
0.009982275,
0.0013125937,
0.024716139,
0.018074416,
-0.018336933,
0.015436102,
0.017549377,
0.00497473,
-0.013624722,
-0.014320397,
0.0151998345,
0.01300124,
0.0127781,
0.006812361,
0.0016218736,
-0.0047286185,
0.009457237,
-0.0040427884,
0.005542427,
-0.032867346,
-0.0059132343,
0.0371464,
-0.018940726,
-0.0007756608,
0.020830862,
-0.001749031,
-0.016801199,
0.0021116352,
-0.014517286,
-0.004669552,
0.019885793,
-0.005368508,
-0.018258179,
0.008604052,
0.056704048,
-0.020633973,
0.009693504,
-0.017785644,
-0.017956281,
0.009929772,
-0.005795101,
-0.020594595,
0.018323807,
0.009942897,
0.014950442,
-0.009089711,
0.0069370577,
-0.0112292385,
-0.00066327,
-0.023088522,
0.010198853,
0.026396258,
-0.0021985944,
-0.033234872,
-0.025543073,
-0.020489587,
-0.0042823367,
-0.005345538,
0.0013322826,
-0.0052405302,
0.007724614,
0.018336933,
0.029323343,
-0.009188156,
0.0131259365,
-0.034127437,
-0.016643688,
-0.015672369,
-0.0075474135,
-0.00851217,
0.0009811638,
0.000957373,
-0.013027492,
0.021054003,
0.012075862,
0.013329389,
-0.019085111,
-0.02122464,
-0.014294145,
0.02500491,
0.016801199,
-0.011800217,
-0.016131775,
0.00046802167,
-0.013237507,
0.019793913,
0.0062446645,
0.024545502,
-0.0099166455,
-0.011065165,
-0.026566897,
-0.02157904,
-0.017772518,
-0.010100408,
-0.016827451,
-0.035492532,
0.00700925,
-0.011760839,
-0.007829621,
0.015777376,
-0.002679332,
0.019452639,
-0.015659243,
-0.018888222,
-0.008846882,
-0.00833497,
0.013611596,
0.0022724278,
-0.03420619,
-0.00016766333,
0.03444246,
0.0025152576,
0.018035037,
-0.0029188802,
0.0019820165,
0.025963103,
-0.01773314,
0.039194047,
-0.016512427,
0.0040985737,
0.015882384,
-0.045048214,
-0.008702496,
-0.0025152576,
0.0053783525,
0.020620847,
0.038038965,
-0.062689476,
0.013585345,
-0.025989356,
0.0014233438,
-0.024191102,
0.016039895,
0.002913958,
0.002334776,
0.0069304947,
-0.008256214,
0.014189137,
0.0036752622,
-0.012994678,
0.002735117,
0.024309235,
-0.007527725,
-0.0019524831,
-0.0032601545,
-0.010205416,
0.00048073742,
-0.0020935868,
0.024204228,
-0.013171878,
0.0034914992,
0.020279571,
0.020791484,
0.008702496,
-0.008728748,
-0.0071470723,
0.014609167,
0.009280037,
-0.038222726,
0.01976766,
0.001421703,
-0.0049451967,
-0.022799753,
-0.014346649,
0.027721979,
0.024414243,
0.022747248,
-0.0043873442,
0.033182368,
-0.02381045,
-0.01640742,
-0.01492419,
0.028404526,
0.019268876,
-0.019780787,
-0.016328664,
-0.014845435,
-0.011353935,
-0.018822594,
-0.014123508,
0.023849826,
-0.0008589285,
0.014031626,
-0.016643688,
0.03701514,
0.022839129,
0.01863883,
0.0131193735,
-0.012856855,
-0.008702496,
-0.0052372487,
0.0062807607,
0.037881453,
-0.0017637977,
-0.0043939073,
0.0042888997,
-0.02509679,
0.0075539765,
-0.0018179422,
-0.03882652,
0.03937781,
0.008754999,
0.020555217,
-0.007534288,
0.019872667,
0.012869981,
0.0048631597,
-0.010395742,
0.009089711,
0.0024020465,
0.012279314,
-0.009450674,
-0.016433673,
0.00083513773,
0.010074156,
0.00073997467,
-0.017050592,
0.0035899437,
-0.00087123405,
-0.020174565,
-0.008919074,
0.0010869916,
0.027643222,
-0.013650974,
0.023036018,
-0.013414707,
0.0037474548,
0.047962174,
0.0026268282,
-0.017339362,
0.035912562,
0.03265733,
0.008525296,
0.0035636919,
-0.0051223966,
-0.027223192,
0.0033864917,
-0.011662395,
0.01001509,
-0.012482766,
0.0044004703,
0.028089505,
0.00046104853,
0.004242959,
0.0112292385,
0.001379864,
-0.0029303653,
-0.0004918124,
-0.012404011,
-0.015790502,
0.03517751,
0.013952871,
0.0032437472,
0.018743837,
0.0031994472,
-0.0044496926,
-0.016932458,
-0.019282,
0.03307736,
0.01618428,
0.0033897732,
-0.018297555,
-0.008485918,
-0.0028909876,
-0.014596041,
-0.00010869916,
-0.006182316,
-0.004758152,
0.0055752415,
0.013532841,
-0.008439978,
-0.0089715775,
0.015501731,
0.03559754,
0.044208154,
-0.029795876,
-0.0054046046,
0.03026841,
-0.007088006,
-0.032893598,
-0.0052175596,
0.011065165,
-0.008886259,
0.041320447,
-0.0022937574,
-0.00791494,
0.013178441,
-0.0008736952,
0.013454085,
-0.009877267,
0.014543538,
0.0140841305,
0.019150741,
-0.0049583227,
0.0047187745,
-0.01737874,
-0.0021772648,
0.03404868,
0.003665418,
0.006277479,
0.018389437,
-0.010421994,
-0.0075802286,
-0.026278125,
0.014320397,
-0.0013437677,
0.0039738775,
-0.010638571,
0.005220841,
0.008735311,
0.00029923033,
0.00021083535,
0.012449951,
-0.011537698,
0.01841569,
0.018783215,
-0.0032174953,
-0.021959692,
-0.017969407,
0.012062736,
0.01450416,
-0.03557129,
0.0055063306,
0.0053192857,
0.016210532,
0.012134928,
0.03599132,
-0.03614883,
0.013782234,
-0.0057097822,
-0.007088006,
0.00019914507,
-0.008256214,
-0.014674798,
0.0016112088,
-0.022852255,
0.02487365,
-0.020003928,
0.003238825,
0.0077836807,
0.0012510659,
-0.0035604103,
0.022274714,
-0.0044201594,
-0.011393313,
0.0005804125,
0.016617436,
0.020437084,
0.0041707666,
-0.01737874,
0.0047187745,
0.00009916235,
-0.0005028875,
-0.007462095,
0.0048828484,
-0.018980104,
-0.0031846804,
0.013257196,
0.00025657105,
-0.011675521,
0.017247481,
-0.0073505244,
-0.004124826,
0.0046268925,
0.012509017,
0.018455068,
-0.015252339,
0.019387009,
0.008472792,
-0.012463077,
-0.025438065,
-0.00223305,
0.013637848,
-0.007823058,
-0.012134928,
0.008656555,
-0.009608186,
-0.009864141,
-0.027774483,
0.011892099,
-0.0075736656,
0.031160973,
-0.016945584,
-0.05701907,
-0.044181902,
0.0025234614,
-0.00362604,
-0.0007083904,
-0.027905742,
0.011964291,
-0.0049845744,
-0.0026776912,
0.019465765,
-0.039561573,
0.043630615,
-0.03950907,
-0.00061609864,
-0.018612579,
-0.0047876853,
0.01799566,
-0.008938763,
-0.0129421735,
-0.026173119,
-0.011924913,
0.009896956,
-0.0399291,
-0.02416485,
-0.016801199,
0.047962174,
0.041162938,
0.012115239,
-0.005673686,
0.0069633094,
0.01372973,
0.009148777,
-0.000030917734,
-0.0069567463,
-0.0061954423,
-0.024204228,
-0.005959175,
-0.006156064,
-0.003429151,
0.008794378,
-0.005542427,
-0.0010640213,
0.016158028,
-0.0036719807,
-0.026238747,
-0.017785644,
-0.0042331144,
-0.031922277,
0.012686218,
-0.0004905819,
0.00075720245,
-0.030373417,
-0.022090951,
0.050141077,
0.041950494,
0.016459925,
-0.04906475,
0.0089650145,
-0.0315285,
0.038038965,
-0.015934886,
0.012627151,
-0.021014625,
-0.025385562,
-0.018665083,
-0.0050469227,
0.021027751,
-0.008604052,
-0.0022871944,
-0.01576425,
-0.021985944,
0.00994946,
-0.0038327735,
-0.025753088,
0.012902795,
-0.002449628,
-0.0013568937,
-0.010067593,
0.004459537,
-0.03570255,
-0.027905742,
-0.011380187,
0.029402098,
-0.04499571,
0.011360498,
-0.00283028,
0.008899385,
0.034127437,
-0.025871221,
0.006405457,
-0.009982275,
0.04678084,
0.011012661,
0.008164332,
-0.006316857,
-0.018691333,
-0.00064070977,
0.008499044,
0.023049144,
-0.003694951,
-0.011255491,
-0.020607721,
0.0085909255,
0.0067795464,
-0.012843729,
-0.012029921,
0.001008236,
-0.0017162162,
-0.0022067982,
-0.009942897,
-0.005959175,
-0.0022002351,
-0.0087812515,
-0.021631544,
0.0039476254,
-0.020962121,
-0.009903519,
-0.014057878,
0.028325772,
0.0008318562,
0.011498321,
0.00068542,
0.01618428,
0.000050709186,
-0.011846158,
-0.019885793,
0.00033060953,
0.029717121,
0.002812232,
-0.0027121466,
0.009641,
0.010284171,
0.009010956,
0.005165056,
-0.012351506,
-0.030609684,
0.03404868,
0.0061659086,
-0.02089649,
0.016276162,
0.01246964,
0.018691333,
0.0048008114,
-0.0138872415,
-0.017628133,
-0.015711747,
0.00599199,
0.008302155,
0.0047220555,
-0.017509999,
-0.0040198183,
-0.014950442,
-0.030373417,
-0.028955817,
0.000612407,
-0.006228257,
-0.03194853,
0.013165315,
-0.0035407215,
0.014884812,
0.017155599,
0.0042167073,
-0.015331094,
-0.0039213737,
0.016551806,
-0.0151998345,
0.042790554,
-0.00018868534,
0.0129553,
-0.00030456274,
0.017969407,
-0.030740945,
-0.02622562,
0.021736551,
0.0003771656,
-0.045730762,
0.0018934164,
0.0018212238,
0.015383597,
0.0037999586,
0.0046531446,
0.010776394,
0.0061855977,
0.015843006,
0.0023626685,
-0.0378552,
0.004594078,
-0.025385562,
-0.0050272336,
0.023574183,
-0.004331559,
0.0036785437,
0.0036851068,
-0.009857578,
-0.005000982,
0.008348096,
0.0053619454,
-0.034022428,
0.037618935,
-0.015790502,
-0.0039049662,
-0.017260607,
-0.0074949097,
-0.013349078,
0.027091933,
-0.0056900936,
0.013611596,
-0.043604363,
-0.015291716,
-0.0028466876,
0.026868792,
-0.006024805,
0.0006956746,
0.0010156194,
-0.015212961,
-0.041556716,
-0.006156064,
-0.022681618,
0.017011214,
0.013559093,
-0.017562503,
-0.016774947,
-0.0060543385,
-0.023889204,
-0.028772052,
0.029060824,
0.018861972,
0.0035571288,
0.0019738127,
0.031397242,
0.011104543,
0.01970203,
0.01899323,
-0.021552788,
-0.030320914,
0.003358599,
-0.003937781,
0.020502713,
-0.007028939,
-0.014162886,
0.010960157,
0.02871955,
-0.016394295,
-0.0087878145,
0.0011033991,
0.0036161956,
0.013303136,
-0.01456979,
0.005109271,
0.0027564466,
0.013060307,
0.014044752,
-0.016354917,
0.0038458994,
0.0044365665,
-0.023246033,
-0.0046531446,
-0.015331094,
-0.0055391453,
0.0054144487,
0.014609167,
-0.025044287,
-0.022169707,
0.012463077,
-0.020410832,
0.0039673145,
0.007665547,
0.019137615,
0.0007961701,
0.018901348,
-0.019872667,
-0.021342773,
-0.012443388,
-0.011399876,
0.007278332,
0.0069895615,
-0.0075080357,
0.0041379514,
0.007665547,
0.019242624,
-0.03155475,
0.005407886,
-0.0142678935,
0.006366079,
-0.017851274,
0.010336675,
-0.0024890057,
-0.013322826,
-0.0059526125,
0.0046728333,
-0.018848846,
0.00047171334,
-0.013480337,
-0.006717198,
-0.00707488,
0.0011559027,
-0.00003758325,
0.006884554,
0.02244535,
-0.005171619,
-0.017562503,
-0.010159475,
0.0082168365,
0.17473248,
-0.014674798,
-0.014582915,
0.012817477,
-0.0064284275,
0.019006357,
0.0072323913,
0.005585086,
-0.008695933,
0.011472069,
0.0035965065,
-0.005667123,
-0.009266911,
0.002182187,
-0.004072322,
-0.010802646,
-0.027433207,
-0.0014134994,
0.00005481104,
0.0051749004,
0.02381045,
-0.035125006,
0.0012494251,
-0.01450416,
0.050324842,
-0.010454808,
-0.0031518654,
-0.020948995,
0.016879955,
0.018560074,
-0.012253062,
0.009805075,
0.0031272543,
0.014937316,
-0.0075474135,
0.009673815,
-0.016551806,
-0.016236784,
0.013355641,
-0.008308718,
0.00085646735,
0.005263501,
-0.01576425,
-0.010973283,
0.021054003,
0.019006357,
-0.004397189,
-0.009115963,
-0.015948012,
-0.009299726,
-0.03375991,
-0.0065301536,
0.021880936,
0.036647614,
0.01815317,
0.0067270426,
0.023232907,
0.015856132,
0.006858302,
0.011557387,
-0.030635936,
-0.010723891,
-0.002589091,
0.010756705,
-0.010093845,
0.014976693,
-0.016131775,
-0.00714051,
0.008308718,
-0.006546561,
0.008275903,
-0.017615007,
-0.019465765,
-0.00539476,
0.003721203,
-0.008052763,
0.03097721,
0.014661672,
-0.020397706,
0.022734122,
-0.0061429385,
-0.0029434913,
-0.024729265,
-0.014254767,
0.001755594,
-0.03656886,
0.03097721,
0.007284895,
-0.026238747,
-0.0057918197,
-0.011288306,
0.006871428,
-0.013349078,
0.0005808227,
0.013395018,
-0.040086612,
0.012607462,
-0.015002945,
0.008052763,
-0.019780787,
-0.010376053,
0.06951496,
0.006864865,
0.020410832,
-0.0058115083,
-0.004331559,
-0.026461888,
0.002003346,
0.037592683,
-0.0011583639,
0.0034127436,
-0.023876078,
-0.0016144902,
-0.013185004,
-0.0014372901,
0.030924708,
0.0315285,
-0.025621828,
-0.004777841,
-0.015685495,
-0.006851739,
-0.008374347,
0.021395277,
0.020791484,
-0.018901348,
0.001065662,
-0.018586326,
-0.0043873442,
0.0052766264,
-0.024112346,
0.009896956,
-0.008505607,
-0.017628133,
-0.0023265723,
0.0121808695,
-0.016630562,
0.012810914,
-0.0025054133,
0.0022986797,
0.036883883,
-0.01870446,
0.01127518,
-0.017680638,
0.020988373,
0.016774947,
-0.022996642,
0.016394295,
-0.0076917987,
-0.01660431,
-0.004315152,
-0.009936334,
-0.018389437,
0.0040788846,
-0.0031863211,
0.016197406,
-0.014911064,
-0.023141026,
-0.054551393,
-0.0061232494,
-0.0037704252,
-0.016906206,
0.0071076946,
-0.002825358,
-0.0038984031,
-0.00023975344,
0.010940468,
-0.16433673,
0.005972301,
0.023849826,
-0.026711281,
0.0148323085,
-0.00994946,
0.009726319,
0.005883701,
-0.0029730247,
-0.008702496,
0.025608702,
0.010723891,
-0.02606811,
-0.0056704045,
0.017129347,
0.00094424706,
-0.007908377,
0.03291985,
-0.006438272,
0.0134934625,
0.011413002,
-0.021710299,
0.017418118,
-0.020200817,
-0.006221694,
0.021565914,
0.011058602,
0.00924066,
-0.0018146607,
-0.019045735,
-0.02856204,
-0.002354465,
0.028509535,
0.024755517,
0.024808021,
-0.009135652,
0.0021362463,
-0.023088522,
0.0013938104,
0.0057097822,
0.022668492,
0.02213033,
-0.01624991,
0.017890653,
-0.013677226,
0.025700584,
0.0040296623,
0.008485918,
0.0009811638,
-0.018336933,
0.018533822,
0.020555217,
-0.0040132552,
0.0043610926,
-0.0040624775,
0.017352488,
0.00049468374,
0.021500284,
-0.0051059895,
-0.021250892,
-0.001762157,
-0.027590718,
0.024742391,
0.016131775,
-0.008794378,
0.00079288863,
-0.0035768177,
0.0076196063,
-0.006497339,
0.011478632,
-0.021329647,
0.0014110382,
0.017903777,
-0.008551547,
0.035623793,
0.01109798,
-0.0021165572,
0.0015316327,
0.008059325,
0.007928066,
-0.007245517,
-0.009299726,
-0.045547,
-0.016906206,
0.00008162692,
-0.017916903,
0.020161439,
0.031344738,
-0.012974989,
-0.006667976,
0.022760374,
-0.025385562,
0.023666063,
-0.01744437,
-0.0044365665,
0.004771278,
0.019071987,
-0.014714175,
0.022025323,
0.00080396363,
0.002900832,
-0.017208103,
0.0075474135,
0.034101184,
0.011176735,
0.007639295,
-0.042501785,
-0.025923725,
0.024151724,
-0.020699602,
-0.002881143,
-0.0027712134,
0.009746008,
0.01764126,
-0.003314299,
0.03137099,
0.012115239,
-0.012719032,
0.02164467,
-0.022340344,
0.08279841,
0.0099232085,
-0.018691333,
0.03179102,
-0.01145238,
-0.04090042,
-0.1416551,
-0.036175083,
0.0104810605,
0.0138872415,
-0.0052470933,
0.027800733,
0.00020991244,
0.007934629,
-0.004853315,
0.03331363,
-0.021408403,
-0.015751123,
-0.007271769,
-0.010330112,
0.0045514186,
-0.0056704045,
0.027800733,
-0.02458488,
-0.015816754,
0.026934423,
0.012850292,
-0.024611132,
0.006513746,
-0.016026769,
-0.0153967235,
0.002577606,
-0.016158028,
0.0099232085,
0.0034586843,
0.0039837216,
0.014372901,
0.0059329234,
-0.0074358433,
-0.0069173686,
0.009680378,
0.00557196,
-0.005509612,
-0.028745802,
0.021264017,
-0.011773965,
-0.0067467312,
0.014005374,
0.036778875,
0.0066384426,
0.00061609864,
0.0025940132,
-0.016000517,
-0.013926619,
0.012922484,
-0.010697639,
-0.017234355,
-0.009575371,
-0.018468194,
-0.026475014,
0.026934423,
-0.03433745,
0.01096672,
0.025569325,
0.007639295,
-0.009995401,
0.024637382,
0.011478632,
-0.01611865,
0.013454085,
0.017562503,
-0.033681154,
-0.0074949097,
-0.01905886,
0.0069239317,
-0.022012196,
0.0056539974,
0.026986925,
-0.002525102,
-0.0047056484,
-0.0050666113,
0.018376311,
-0.0039082477,
-0.017943155,
-0.0091619035,
-0.009273474,
-0.016381169,
-0.012686218,
0.019439513,
-0.012351506,
-0.013171878,
-0.013559093,
0.008151207,
0.0041051367,
-0.010054467,
0.009043771,
-0.020463334,
0.02887706,
0.025897473,
-0.020017054,
-0.008315281,
0.0032831249,
-0.001262551,
-0.00532913,
0.023587309,
0.016354917,
-0.0110520385,
-0.011065165,
-0.03373366,
0.0114195645,
0.0063988944,
-0.0007424358,
0.001339666,
-0.017785644,
0.007868999,
-0.008282466,
0.005985427,
0.0016128494,
-0.013572219,
-0.008065888,
-0.0029090357,
-0.029323343,
-0.027354453,
-0.022734122,
0.02887706,
-0.0011616454,
0.028325772,
0.017930029,
0.007947755,
0.011531135,
0.015002945,
0.017194977,
-0.0021592167,
-0.008958451,
-0.0031699138,
0.014871687,
-0.008505607,
-0.0071667614,
0.012587774,
-0.037487675,
-0.0037737067,
0.0032782026,
-0.020922743,
-0.021027751,
-0.0008330868,
0.026803162,
0.012909358,
0.047227122,
-0.0073242728,
-0.013178441,
0.011353935,
-0.021054003,
0.0018277867,
-0.004183892,
-0.031055966,
0.0027564466,
0.0066450057,
-0.027144438,
0.016013643,
0.02409922,
0.0027400393,
-0.01054669,
-0.0027909023,
0.0024397834,
0.021355899,
-0.0034586843,
-0.028850809,
-0.02261599,
0.011071728,
0.025634954,
0.018441942,
-0.012699344,
0.015186708,
0.007731177,
-0.03249982,
-0.010815772,
0.010362927,
-0.007974006,
-0.02564808,
0.012574648,
0.033864915,
0.0005123217,
0.010914217,
-0.007048628,
-0.026829414,
0.009404734,
0.015147331,
0.03097721,
0.008741874,
0.013808485,
-0.026527518,
0.015659243,
0.029507106,
-0.006152783,
-0.028745802,
0.023613561,
0.01534422,
0.0010730453,
0.0014258049,
0.008722185,
0.008479355,
-0.0069764354,
0.00886657,
0.019203246,
-0.015462354,
-0.0038524624,
-0.008499044,
0.044549428,
0.007409591,
0.008348096,
-0.007015813,
-0.02774823,
-0.010520439,
0.019570772,
-0.013152189,
-0.03465247,
-0.025897473,
0.008361221,
-0.0008736952,
0.024663635,
0.015567361,
0.0035079066,
-0.009975712,
0.015501731,
-0.019176994,
0.0015685494,
-0.012121802,
-0.011767402,
0.009148777,
-0.013237507,
-0.008289029,
-0.0018048163,
0.0023807168,
-0.0023872796,
0.006270916,
-0.019019483,
0.02493928,
-0.009798512,
0.037723944,
-0.010376053,
-0.027695727,
-0.021145884,
-0.014674798,
-0.04150421,
0.0048762853,
-0.0014052956,
-0.018100666,
0.06426459,
-0.001472566,
-0.014359775,
0.014989819,
-0.022681618,
0.039010283,
-0.008000258,
0.015068576,
-0.030452173,
-0.0026711281,
0.005096145,
-0.012318691,
0.010802646,
-0.040585395,
-0.02522805,
0.028798304,
0.015961139,
0.014176012,
0.022012196,
-0.013073433,
0.010074156,
-0.020515839,
-0.00022621732,
-0.009831327,
-0.018651957,
-0.030084647,
0.04528448,
-0.00075597194,
-0.012167743,
-0.028273268,
0.013427833,
-0.018087542,
-0.025149295,
0.0069895615,
0.012915921,
-0.032552324,
-0.009851015,
-0.023666063,
0.018783215,
0.03126598,
-0.0091553405,
0.00021965435,
-0.03391742,
0.013545967,
-0.031633507,
0.0058115083,
0.009713193,
-0.003694951,
-0.028955817
] |
The PANTHER (protein annotation through evolutionary relationship) classification system (http://www.pantherdb.org/) is a comprehensive system that combines gene function, ontology, pathways and statistical analysis tools that enable biologists to analyze large-scale, genome-wide data from sequencing, proteomics or gene expression experiments. The system is built with 82 complete genomes organized into gene families and subfamilies, and their evolutionary relationships are captured in phylogenetic trees, multiple sequence alignments and statistical models (hidden Markov models or HMMs). Genes are classified according to their function in several different ways: families and subfamilies are annotated with ontology | [
-0.014583086,
-0.016476652,
-0.019987637,
-0.027325204,
0.001626461,
0.016253104,
-0.0021483423,
0.012505423,
-0.009007586,
-0.014924979,
-0.012525148,
0.0008999368,
-0.0026710453,
0.0021187554,
0.011466592,
0.024050914,
0.025023995,
-0.013439056,
-0.015595617,
-0.0025165356,
-0.009619051,
0.023367126,
-0.013662602,
-0.03584625,
0.01127592,
0.016279405,
0.006653779,
-0.044025403,
-0.011650689,
0.008034504,
0.016976342,
-0.009533577,
-0.016253104,
-0.00798848,
-0.0077452096,
0.0022288845,
0.013347007,
-0.002131905,
0.009836022,
0.0064302334,
0.021697106,
0.0068576005,
0.0086854175,
-0.013458781,
0.019501096,
-0.023025231,
0.008369823,
-0.016358303,
-0.0118413605,
0.011887385,
-0.0010906083,
0.021105368,
0.0036391965,
-0.008547345,
-0.008468446,
0.0016141332,
-0.0016831694,
0.0093166055,
-0.0077254847,
-0.006574881,
0.007600562,
0.0047404887,
-0.023603821,
0.0030704692,
-0.028903175,
-0.021631358,
0.0000050884696,
0.016581848,
0.0032726468,
0.0192118,
0.063224055,
0.027614499,
0.0007133745,
0.011124698,
0.01713414,
-0.0022650464,
0.0015146881,
-0.010743355,
-0.013031414,
0.009185108,
0.00050955324,
-0.013978196,
0.017173588,
0.008428997,
0.021920651,
-0.018988255,
0.014241192,
0.011131273,
0.00240805,
0.003530711,
0.016844844,
0.0028814415,
0.0010010256,
-0.009395504,
-0.021552458,
0.017436583,
0.00017556986,
0.008435572,
0.007830683,
-0.041737344,
-0.023288228,
0.035925146,
-0.01153234,
-0.013846698,
-0.008981287,
-0.0002971024,
-0.015043327,
0.002332439,
0.015648216,
0.010855128,
-0.013557404,
0.046339758,
-0.0026052964,
-0.034662772,
0.04565597,
-0.025300141,
0.030586345,
-0.00084733777,
0.011552066,
0.012538297,
0.01372835,
-0.00067885645,
0.020671425,
-0.0046714526,
0.020987019,
0.009836022,
-0.0015179756,
-0.022341445,
-0.026141725,
0.011676988,
0.016976342,
-0.0014398989,
0.022315145,
0.011946558,
-0.015174825,
0.007837257,
0.005808907,
-0.015003878,
-0.01592436,
-0.03418938,
0.0063283225,
0.025129193,
-0.014517336,
-0.0054998877,
-0.021355212,
0.015266873,
0.028456083,
0.008954988,
0.012728969,
0.007265243,
0.01597696,
0.009803147,
-0.0028847288,
-0.027930092,
0.013136611,
-0.005345378,
0.02535274,
0.003008008,
0.0038989042,
-0.005743158,
-0.014385839,
0.0053946897,
-0.007659736,
0.006114639,
0.023090981,
0.03752942,
-0.0076860357,
-0.006538719,
-0.006653779,
-0.012538297,
-0.009540152,
0.03127013,
-0.00019395899,
0.0072520934,
0.010572408,
-0.0005391402,
-0.0032627846,
0.010973476,
-0.03366339,
-0.01868581,
0.001168685,
0.0014283928,
0.0048719863,
0.012505423,
-0.00831065,
-0.00909306,
0.026891261,
-0.013965046,
0.01372835,
-0.008981287,
-0.006111352,
0.011150997,
0.001362644,
0.008113403,
-0.6442331,
0.0067524025,
0.028245687,
-0.027982691,
0.0068115764,
0.0078438325,
-0.001386478,
-0.017107839,
-0.017160438,
0.015148525,
-0.0070351223,
-0.0055064624,
0.015358921,
-0.018843608,
-0.019198652,
-0.042605225,
0.0028617168,
-0.03253251,
0.015082777,
0.007173195,
-0.02430076,
-0.00091719587,
-0.00482925,
0.01600326,
-0.008113403,
-0.006101489,
0.040501263,
-0.005243467,
0.0032545659,
0.007699185,
-0.022998933,
0.018370217,
0.0024442119,
-0.0071468954,
0.038949594,
0.011624389,
0.006052178,
0.036135543,
0.028456083,
0.03631964,
-0.0029586963,
-0.011986007,
0.018791009,
0.029350268,
-0.03805541,
0.00538154,
0.010145041,
-0.007758359,
0.021381512,
-0.016305704,
-0.0017554931,
0.01760753,
0.006390784,
-0.0077978084,
-0.024498004,
-0.010657881,
0.045340378,
-0.025655184,
0.010953751,
-0.017252486,
0.0066044675,
-0.00057817856,
0.0038561674,
-0.02531329,
-0.016923742,
0.029981455,
-0.0136494525,
0.015017027,
-0.0017242625,
-0.01593751,
0.01763383,
0.016358303,
-0.009066761,
0.009448104,
0.010079292,
0.030638944,
0.021302612,
0.011769037,
-0.015477269,
0.010684181,
-0.0036194718,
0.01131537,
0.0050264965,
-0.007824108,
0.0275619,
0.014359539,
-0.0075150887,
0.017778477,
0.021171115,
-0.0076268613,
0.007778084,
-0.013833549,
-0.030507445,
-0.016187357,
-0.017278787,
0.0076465863,
-0.016371453,
-0.026233774,
-0.0109143015,
-0.046576455,
-0.004316409,
-0.026168024,
0.021618208,
-0.006515707,
0.0055952235,
-0.008461871,
-0.0138203995,
0.009868896,
0.020105986,
-0.0010182846,
-0.0076202867,
0.00088349957,
-0.0027055633,
-0.005397977,
-0.021210564,
-0.030612644,
0.031638324,
0.0024343496,
-0.015174825,
-0.012485699,
-0.018830458,
-0.002366957,
-0.0032562097,
-0.019514246,
0.020171734,
0.02595763,
-0.013925597,
-0.061961677,
-0.0094415285,
0.006167238,
-0.009882046,
-0.02314358,
-0.0097373985,
-0.005657685,
0.020132285,
0.001521263,
0.021776006,
0.015884912,
0.0028436359,
-0.025615735,
-0.016016409,
-0.040106773,
-0.010980051,
-0.00057900045,
-0.021407811,
-0.011157572,
-0.008652543,
-0.003665496,
0.023248779,
0.0008041901,
-0.004224361,
0.00071378547,
-0.0192644,
0.01541152,
0.018133521,
-0.0033433267,
-0.0088563645,
-0.020776622,
-0.0151616745,
-0.021907503,
0.0028271987,
0.00934948,
-0.016726496,
-0.0065584434,
0.0037608317,
-0.0130182635,
0.0024885924,
0.040474966,
-0.039396685,
-0.043657206,
0.016318854,
-0.011663838,
0.0051185447,
0.021171115,
0.0048884237,
0.008060804,
-0.0033992133,
-0.0219864,
-0.010822253,
-0.016095309,
0.0041980613,
-0.0049607474,
-0.0035964597,
-0.009112785,
0.008521046,
0.0026529643,
0.028482383,
0.013570554,
-0.010099017,
0.013886148,
0.0045892666,
0.01702894,
-0.014398988,
0.0060817646,
-0.020710874,
0.0032742906,
0.0056708343,
0.026457319,
0.0046583028,
0.019382749,
-0.0028337736,
-0.020447878,
-0.008113403,
-0.013406182,
0.002314358,
-0.0039284914,
-0.00059543765,
-0.011775611,
-0.006864175,
-0.0107893795,
0.025300141,
-0.0072389436,
-0.027351504,
-0.014661984,
0.020132285,
0.0164372,
-0.007850408,
0.0014686639,
-0.015095926,
-0.01236735,
0.009882046,
0.0058647934,
0.014214892,
-0.00037928842,
0.00563796,
-0.007712335,
0.01592436,
0.04452509,
-0.0032825093,
-0.016976342,
-0.0058056195,
0.015450969,
0.011499466,
0.018646361,
0.03205912,
-0.00771891,
0.026391571,
-0.016923742,
0.025431639,
-0.011032649,
-0.018462265,
0.0067326776,
0.013583703,
-0.011400843,
0.021933801,
-0.010092442,
0.012847316,
0.01815982,
-0.0011596446,
0.0060258782,
-0.001985614,
0.018278169,
-0.032769207,
0.00882349,
0.015740264,
-0.022814836,
0.0005070877,
0.00008377836,
0.05454521,
0.0072455183,
0.01873841,
-0.009165384,
0.005927255,
0.0047141896,
0.025931329,
-0.0031181371,
0.0015968741,
-0.018304467,
0.010269963,
-0.011466592,
0.0045563923,
-0.02030323,
0.009987243,
-0.02869278,
0.004119163,
-0.0032759344,
0.014254341,
0.018646361,
0.013741501,
0.00854077,
-0.02089497,
-0.034320876,
0.0017850801,
0.028008992,
-0.010059567,
-0.0247873,
-0.011387694,
-0.020342682,
-0.013610003,
0.012834167,
0.011907109,
0.013366733,
0.022262545,
0.004664878,
-0.00064105086,
-0.0062461365,
0.016726496,
-0.027141107,
-0.002841992,
0.0061508007,
-0.017042091,
-0.00007324828,
0.0034222254,
-0.007291543,
0.049127508,
0.0040139644,
-0.006002866,
-0.013951897,
-0.006239562,
-0.014714583,
0.026654566,
-0.0072060693,
0.017291937,
-0.018830458,
-0.024050914,
0.004941023,
-0.0016881006,
0.016108457,
0.042210735,
0.012604047,
-0.006818151,
-0.04244743,
-0.010408036,
0.008179151,
0.03960708,
0.0061540883,
-0.012485699,
0.0012697738,
-0.021407811,
-0.0018902782,
-0.03960708,
0.005756308,
0.011124698,
-0.014464738,
-0.027719697,
0.010592133,
0.008705142,
0.007383591,
0.011709862,
0.019553695,
-0.015003878,
-0.029402867,
-0.016779095,
-0.023288228,
-0.001380725,
-0.013886148,
0.025221242,
0.021605058,
0.012617196,
-0.014385839,
0.0096519245,
-0.0019987638,
0.0043131215,
-0.026628267,
-0.011611239,
-0.0022239534,
-0.0193433,
0.018567463,
-0.0149118295,
-0.0013420975,
-0.0073901657,
0.017370835,
0.014740882,
-0.00137415,
0.004964035,
0.024905648,
0.00455968,
-0.009448104,
-0.021789154,
0.008534195,
0.004885136,
0.013925597,
0.006420371,
-0.0016544043,
-0.021894353,
0.0021845042,
-0.006397359,
-0.007856983,
0.017476033,
-0.013675752,
-0.008751166,
0.0033120962,
-0.0060061533,
-0.02533959,
-0.009014161,
-0.013517954,
0.025812982,
-0.030139253,
0.0010889646,
0.00480295,
0.012821017,
-0.038949594,
-0.012781568,
-0.019935038,
0.019869288,
-0.036687832,
0.006361197,
-0.007291543,
0.027114809,
0.008304074,
-0.005233605,
-0.015674515,
-0.00883664,
0.028771678,
-0.00276145,
-0.00606204,
-0.013938747,
-0.04355201,
0.0034846868,
0.0059765666,
-0.013925597,
-0.019106602,
0.006466395,
0.0131037375,
-0.007225794,
-0.02864018,
0.019750942,
0.037345324,
0.0080542285,
0.01977724,
0.01295909,
0.018777858,
-0.009829447,
-0.038896993,
0.019816691,
-0.033926383,
-0.017397134,
-0.016174207,
0.025602585,
0.01869896,
-0.005703709,
0.0054571507,
-0.027903793,
-0.029560663,
0.02423501,
-0.016950043,
0.019619444,
0.014175443,
0.013064288,
0.004306547,
0.014385839,
0.014030796,
0.016016409,
-0.03205912,
-0.014661984,
0.0119662825,
0.010105591,
0.032690305,
-0.046786852,
0.022749087,
-0.005578786,
0.0031575863,
-0.007981905,
-0.010855128,
-0.013320709,
0.04231593,
-0.0021335487,
-0.014412139,
-0.020750323,
0.015700815,
-0.032164317,
-0.0029619837,
-0.017739028,
-0.013544254,
-0.005868081,
-0.0331111,
0.0110458,
-0.0037148076,
0.0015196193,
-0.026641417,
-0.01759438,
0.0062066875,
0.008711717,
0.009283732,
-0.03240101,
0.013978196,
-0.0017932988,
-0.00005732474,
-0.019014554,
-0.043262716,
-0.029218769,
-0.0077386345,
0.06474943,
0.03134903,
0.0064532454,
-0.014924979,
0.020119134,
0.046576455,
-0.016871143,
-0.008382973,
-0.031191234,
-0.012419949,
-0.034320876,
0.0030770442,
0.0082449,
-0.009014161,
-0.010717056,
0.0022354594,
0.024498004,
0.012354201,
-0.000007242642,
-0.006078477,
-0.0042868224,
-0.039764877,
-0.022236247,
0.028982073,
0.0024474994,
0.019961338,
-0.028719079,
-0.0066866535,
0.026338972,
-0.0013248385,
0.0074953637,
0.004835825,
0.020737173,
0.013452206,
0.04060646,
-0.0005239358,
0.019606294,
-0.017739028,
-0.0061540883,
-0.018554313,
0.009428379,
0.008915538,
-0.006420371,
0.038607698,
-0.006039028,
0.0054012644,
-0.0086459685,
-0.0008296677,
-0.008080528,
-0.00992807,
0.003501124,
0.016765947,
-0.0059075304,
-0.021907503,
-0.022920035,
-0.028008992,
0.0065452936,
0.024879348,
-0.01541152,
0.014254341,
-0.015700815,
-0.035030965,
0.025168642,
0.009303456,
0.04741804,
0.001110333,
0.037555717,
0.040080473,
0.004188199,
-0.02974476,
-0.0058878055,
-0.0030638943,
0.013320709,
0.019146053,
0.015135375,
0.011262771,
-0.010717056,
0.02533959,
-0.0031460803,
-0.028955774,
-0.02803529,
0.02424816,
-0.009743973,
0.031585727,
-0.014977578,
0.013583703,
-0.017226188,
0.0023160018,
0.00047503514,
0.024958247,
-0.017988874,
-0.0063480474,
-0.0164372,
0.027903793,
-0.0063118855,
0.005016634,
-0.010888003,
-0.019080304,
-0.0025116045,
0.00044133887,
0.015385221,
-0.026089126,
0.028719079,
0.022262545,
0.011473167,
-0.020526778,
0.011801911,
0.005674122,
-0.00062461366,
-0.0010725274,
-0.004270385,
0.03150683,
-0.017042091,
-0.017423434,
-0.0064532454,
0.015069626,
0.027483001,
0.010486934,
0.011052375,
-0.022407193,
-0.02474785,
0.0081397025,
0.02370902,
0.026917562,
0.019514246,
0.003658921,
-0.014425288,
-0.0025609161,
-0.030139253,
-0.018304467,
-0.00400739,
-0.055334195,
-0.018554313,
-0.0035142738,
0.0066274796,
0.025050296,
0.018593762,
-0.015635066,
-0.012538297,
0.029323967,
-0.007225794,
0.033847485,
0.005059371,
-0.007837257,
-0.05680697,
-0.010447485,
-0.0385025,
-0.023866817,
0.017541781,
-0.029166171,
-0.0063579096,
-0.012209553,
-0.0083500985,
0.015608767,
0.02096072,
-0.0151222255,
0.032690305,
-0.008356674,
0.017896825,
-0.011341669,
-0.023524923,
0.0019050717,
-0.030375948,
0.01985614,
0.002026707,
-0.016134758,
0.007554538,
0.006085052,
-0.025181793,
-0.0049969093,
-0.016108457,
-0.037134927,
-0.02257814,
0.03355819,
0.011676988,
0.013715201,
-0.020710874,
-0.020671425,
-0.02366957,
0.0014407207,
0.0030934813,
-0.010026693,
-0.0011300576,
0.014385839,
0.026115427,
-0.019882439,
-0.023498623,
-0.016200505,
0.0074822144,
-0.017778477,
-0.037266422,
-0.023603821,
-0.023498623,
0.030691544,
0.0385288,
-0.026891261,
-0.04681315,
-0.001679882,
-0.044919584,
-0.02913987,
-0.00030326637,
0.018265018,
-0.000027532313,
0.028876876,
0.0051119695,
0.01434639,
-0.014688283,
0.0052368925,
-0.002084237,
-0.0068115764,
-0.006466395,
0.011552066,
0.0067918515,
-0.001321551,
-0.04186884,
-0.005164569,
0.027404103,
-0.022433493,
-0.02259129,
0.016174207,
-0.040553864,
0.028929476,
-0.014517336,
0.043815006,
0.0011736162,
0.02038213,
0.013182635,
-0.025089744,
-0.014293791,
0.012650071,
-0.012518573,
-0.015806014,
0.013149762,
-0.0007031013,
-0.007778084,
0.024668952,
-0.0013116887,
-0.02811419,
-0.007429615,
0.018383367,
-0.0005633851,
0.020342682,
-0.027404103,
0.027088508,
0.00937578,
0.011880809,
-0.0058976677,
-0.011190447,
-0.0005720146,
0.0097373985,
0.00064022903,
-0.0056412476,
0.021578759,
-0.028245687,
-0.008830065,
-0.021039618,
0.0007413178,
-0.0022518965,
-0.0061475136,
-0.01298539,
0.016121607,
0.007291543,
-0.01487238,
-0.004470919,
-0.014569935,
0.0002521056,
-0.006778702,
0.0033055213,
-0.006502557,
0.004503793,
0.022117898,
-0.0024820175,
-0.0053552403,
-0.024432257,
-0.01871211,
-0.005276342,
-0.020776622,
0.0015327691,
0.1758912,
-0.021289464,
0.01378095,
0.028140489,
0.017936274,
0.012347626,
0.0029932144,
0.016200505,
-0.0013782594,
-0.009974094,
0.0026299523,
0.011190447,
0.00990177,
0.0020530066,
0.03182242,
-0.0030885502,
-0.020132285,
-0.008481596,
-0.02597078,
0.007442765,
-0.0012615552,
-0.0016108458,
-0.0056708343,
-0.020105986,
0.03142793,
-0.0002120399,
-0.020802923,
0.0013725064,
0.01048036,
0.015135375,
-0.0165687,
0.016660748,
0.004142175,
0.018975105,
-0.007600562,
0.011348244,
0.012544872,
0.016397752,
0.0097373985,
0.013300983,
0.0006237918,
-0.0014818137,
0.01541152,
-0.0132286595,
0.006354622,
-0.011775611,
0.015556168,
0.015556168,
-0.044814385,
0.008691993,
-0.02706221,
0.016450351,
0.0067096655,
0.01984299,
-0.0275882,
0.0088563645,
0.0075413883,
0.0076465863,
0.010408036,
0.021657657,
-0.007107446,
0.0028502108,
-0.008021355,
0.03371599,
-0.01128907,
0.021223715,
0.00004386678,
0.018948806,
0.005519612,
-0.012012307,
-0.0035208487,
-0.020579377,
-0.00027039196,
0.008363248,
-0.029560663,
-0.0054472885,
0.0023340827,
0.012722394,
0.003478112,
-0.00058475346,
0.016660748,
-0.010841978,
-0.031217534,
0.0038923293,
-0.02094757,
-0.029823659,
0.026273223,
-0.00990177,
-0.019395897,
-0.004858837,
0.00879719,
0.003448525,
-0.0067326776,
-0.025010847,
-0.0025280416,
0.015306322,
-0.0025263978,
0.03266401,
-0.010756505,
-0.017213037,
-0.042841922,
0.04515628,
0.0042802473,
0.025010847,
-0.024090363,
0.021407811,
-0.02526069,
0.006818151,
0.0078043835,
0.010348862,
0.00003631594,
-0.024879348,
-0.008928688,
-0.01157179,
0.013517954,
0.012998539,
0.032269515,
-0.014530486,
0.02038213,
0.005384827,
-0.02526069,
-0.014675134,
-0.017817926,
0.036056645,
-0.0029291094,
-0.0025822844,
0.01208463,
0.009356055,
0.00078076706,
-0.025668334,
0.011801911,
-0.022420343,
-0.0021006744,
0.011624389,
-0.03416308,
-0.0019346586,
-0.014951278,
0.0038101433,
-0.036766734,
0.008481596,
-0.007094296,
-0.0011653976,
-0.0022634026,
0.011690138,
-0.00043270932,
0.0067524025,
0.0275093,
0.013965046,
-0.011157572,
0.0025428352,
0.00024306512,
-0.019566845,
-0.014228041,
-0.0077846586,
0.007903007,
-0.027824895,
0.0025543412,
-0.022959484,
0.0028814415,
-0.035951447,
-0.018396515,
0.0059404047,
0.040317167,
-0.0123805,
-0.0071929195,
-0.0003883289,
-0.1650558,
-0.0064466703,
0.028876876,
-0.016687047,
0.02591818,
0.019317,
0.03747682,
-0.003718095,
0.006390784,
-0.013715201,
0.017949425,
-0.025799831,
-0.042657826,
-0.033505592,
0.005480163,
0.013872998,
0.010894577,
0.029639563,
0.017278787,
-0.009770272,
0.030218152,
-0.0070285476,
0.004004102,
-0.009283732,
-0.004862124,
0.018488564,
0.0032677157,
0.012071481,
-0.012229278,
-0.020855522,
-0.0035044113,
-0.003067182,
0.024484856,
-0.016371453,
-0.0017341247,
0.016726496,
0.0030934813,
-0.0031164933,
-0.013675752,
0.0013166198,
0.03192762,
0.013846698,
0.011433718,
-0.0010552683,
0.012860467,
-0.0038397303,
0.023248779,
0.00881034,
0.03345299,
-0.028140489,
-0.013991346,
0.034925766,
0.038344704,
0.016239956,
0.04918011,
0.0029455465,
0.003108275,
0.011709862,
0.009217983,
-0.00770576,
-0.0019806828,
0.0012566241,
0.0014160649,
-0.016976342,
0.005473588,
-0.004918011,
-0.024761,
0.010177915,
-0.006085052,
0.00468789,
-0.0137941,
0.0026825513,
-0.0025263978,
-0.011696713,
0.00094431726,
0.0037904186,
-0.02088182,
0.0070088226,
0.0011012926,
-0.0032611408,
0.004911436,
0.0010067786,
-0.008915538,
-0.007659736,
0.023327677,
0.011052375,
0.018554313,
0.013925597,
-0.010947176,
0.0042966846,
0.014688283,
-0.03361079,
-0.007330992,
0.0030343074,
0.0330322,
0.016608149,
-0.0165424,
-0.012926215,
0.017160438,
-0.0058647934,
0.00937578,
0.010881428,
-0.0024392807,
0.0068576005,
0.032927003,
0.008678842,
-0.0069627985,
-0.0006833767,
0.046944648,
0.005628098,
0.0044314694,
-0.0027828182,
0.031296432,
0.015003878,
-0.021184266,
0.026273223,
-0.016082158,
-0.025878731,
-0.0053946897,
-0.031296432,
0.043289013,
0.020539926,
0.016318854,
0.027404103,
-0.0046681655,
-0.035057265,
-0.11887384,
-0.0247347,
0.012709244,
0.016239956,
-0.02924507,
-0.008922113,
0.0027154258,
0.019514246,
-0.02314358,
0.031033436,
-0.0037049453,
-0.025549985,
-0.0117164375,
-0.03029705,
-0.00607519,
0.021210564,
-0.020789772,
-0.009388929,
0.0036030347,
0.02924507,
0.021289464,
-0.013051138,
0.020763474,
0.008987862,
0.0124725485,
-0.00010673908,
-0.014477887,
-0.006571593,
0.010145041,
0.031217534,
0.011164147,
-0.00881034,
0.012189829,
-0.002713782,
-0.01593751,
-0.0077386345,
-0.009993819,
-0.0164372,
0.026246924,
0.0045300927,
0.0052303174,
0.0048654117,
0.0151222255,
-0.028482383,
-0.00059173926,
-0.010809104,
0.010934027,
0.0046352907,
0.024208711,
-0.016161056,
-0.015595617,
-0.011861085,
-0.03908109,
-0.015345772,
0.008790615,
-0.013846698,
0.0077912337,
0.01375465,
0.012235853,
0.0037509694,
-0.013189211,
0.008843214,
0.012413375,
0.02861388,
0.005174431,
-0.0012295027,
-0.019921888,
-0.004178337,
0.040422365,
-0.01714729,
0.007942456,
0.022972632,
-0.00937578,
-0.010289689,
-0.0116309635,
-0.006542006,
-0.03589885,
0.0060719023,
-0.0004939379,
-0.034557573,
0.0038200056,
-0.01655555,
-0.0136494525,
0.00014608563,
0.006167238,
0.0023176454,
0.009592751,
-0.016818544,
-0.010052993,
-0.016936893,
0.004142175,
0.020513628,
0.017436583,
-0.014714583,
-0.0031822422,
-0.00029751335,
0.009125934,
-0.0021549172,
-0.0029159596,
0.02586558,
-0.02974476,
-0.009540152,
-0.059016127,
0.012222704,
0.00032093635,
-0.005861506,
0.025747232,
0.0028978786,
0.020079685,
-0.009789998,
0.008073953,
0.014451588,
-0.010894577,
0.010171341,
0.0023061393,
-0.005568924,
0.0047010398,
-0.010743355,
0.030007755,
-0.0014456519,
0.015898062,
0.018922506,
-0.002362026,
0.011538915,
0.043709807,
0.02100017,
-0.019553695,
-0.012991964,
-0.0130182635,
0.027930092,
-0.016371453,
-0.0008588438,
0.0018689098,
-0.019961338,
-0.00095828885,
0.020342682,
-0.0016881006,
-0.02260444,
0.0070351223,
0.0030392385,
0.026075976,
0.03368969,
-0.012781568,
-0.03792391,
-0.0104540605,
-0.022157349,
-0.004641866,
0.0019346586,
-0.017988874,
0.005069233,
0.004421607,
0.0013322352,
0.028377185,
0.005950267,
-0.022433493,
-0.029402867,
0.002401475,
-0.007061422,
0.019461647,
-0.008869514,
0.005115257,
-0.035977747,
0.025602585,
0.03411048,
0.021881202,
-0.0040731383,
-0.024590055,
-0.008238326,
-0.021263164,
0.0018689098,
0.0075150887,
-0.032374714,
-0.0086459685,
0.0080542285,
0.0047404887,
0.011808486,
0.022301994,
-0.014964429,
-0.02693071,
0.002302852,
-0.008705142,
0.030112954,
0.026220623,
-0.0029455465,
0.0033515454,
0.034084182,
0.045419276,
0.009941219,
-0.026628267,
0.007896432,
-0.000079771795,
0.013978196,
-0.012439674,
0.013715201,
-0.0051185447,
0.0067392527,
-0.019566845,
0.013951897,
-0.014569935,
0.010085867,
-0.0045563923,
0.021381512,
-0.030454848,
0.011782186,
-0.015030177,
-0.009960944,
-0.026536219,
-0.012413375,
-0.024918798,
-0.024761,
-0.018435966,
-0.025510537,
0.020053387,
-0.032216914,
-0.01159809,
-0.007278393,
-0.00016570753,
0.01593751,
0.002325864,
-0.008172576,
-0.021539308,
0.0066636414,
0.026154876,
0.01767328,
0.011098399,
0.020198034,
0.012327901,
0.038186908,
0.02088182,
-0.026680866,
0.023209328,
0.027719697,
-0.03461017,
-0.01596381,
-0.005384827,
-0.008290924,
-0.02971846,
0.0075874124,
0.008922113,
0.0037937062,
0.00825805,
0.06769497,
-0.0056412476,
-0.008606519,
-0.009310031,
-0.0059995786,
-0.0019083591,
0.02971846,
0.0052960664,
-0.014583086,
-0.0037608317,
0.0006455711,
-0.029560663,
-0.0065814555,
-0.032295812,
-0.017002642,
0.013833549,
-0.03631964,
-0.0014916761,
-0.0027713121,
-0.0112496205,
0.016213655,
-0.0060357405,
0.022039,
0.012255577,
-0.025076594,
-0.004839112,
0.015253723,
0.007501939,
0.02255184,
-0.040474966,
0.02144726,
-0.007837257,
-0.05459781,
0.004464344,
-0.009520427,
0.005937117,
-0.011650689,
-0.0119662825,
0.012327901,
0.029928857,
-0.0026924135,
-0.028508682,
-0.0008703498,
-0.023472324,
0.0007832327,
-0.0037213825,
-0.0151222255,
-0.012229278,
0.0031214247
] |
Fibrous dysplasia is a benign bone disease caused by a mutation in the gene for the stimulatory guanine nucleotide-binding protein Gs alpha, leading to high cyclic adenosine monophosphate levels. Histologically, fibrous dysplasia is characterized by the production of fibrous tissue accompanied by the deposition of ectopic type I collagen and other bone-associated extracellular matrix proteins, as well as by irregular woven intramembranous bone onto which type I collagen-containing Sharpey fibers are often attached. Fibrous dysplasia is also characterized by high expression of c-Fos/c-Jun, known targets for cyclic | [
-0.032338515,
0.009508588,
-0.009854597,
-0.028292876,
-0.04865416,
0.024287157,
-0.030661704,
0.014692067,
-0.020973457,
0.0025667865,
0.016887892,
-0.0030774823,
0.006953446,
0.015091307,
-0.003865983,
0.020933533,
0.026136974,
0.0045014415,
0.0019030485,
0.012196811,
-0.013747197,
0.032524828,
0.0019596077,
-0.0256845,
0.0049705496,
0.01676812,
0.009155925,
-0.030102767,
-0.012489587,
0.011438253,
0.014731991,
-0.0033419793,
-0.007658772,
-0.010353648,
0.023408826,
0.0053165588,
0.006314661,
-0.017020972,
0.030821402,
-0.008676836,
0.006441087,
0.0022856544,
-0.0016244116,
-0.0061216946,
-0.001904712,
-0.0061017326,
-0.0003524549,
0.0015745065,
-0.012383123,
-0.018205388,
0.010832737,
0.023342287,
-0.018072307,
0.011411637,
-0.003175629,
-0.004145452,
0.023488676,
-0.00435838,
-0.0004110934,
-0.02548488,
-0.009867906,
-0.0008051359,
-0.026110359,
-0.003466742,
-0.02980999,
0.011092245,
-0.0007315258,
0.012875521,
-0.010187298,
-0.005146881,
0.03460088,
0.024446854,
-0.021865096,
-0.026443059,
0.035532445,
-0.009987677,
-0.022597037,
-0.0015678525,
-0.027707322,
0.0015720113,
0.00831752,
-0.034441184,
0.0050038197,
0.015490549,
0.023368903,
0.014239593,
-0.015876481,
0.015477241,
-0.008923035,
-0.009721517,
0.034627497,
0.022943046,
-0.005905439,
0.0039857556,
-0.027135076,
0.003822732,
0.017393596,
0.021505779,
-0.016036177,
-0.022903122,
-0.0093622,
0.039178845,
-0.0044482094,
-0.009681593,
-0.020268131,
0.0065375706,
0.010267146,
0.0015453951,
0.015982946,
-0.028984893,
-0.032950684,
0.024819478,
0.0071064886,
-0.027627474,
0.017366981,
-0.0136407325,
0.026868915,
0.017792838,
0.015477241,
0.0003749122,
0.006005249,
0.000056247227,
0.017766222,
-0.0034534342,
0.011584641,
-0.006700594,
-0.038646523,
0.008916381,
-0.023701604,
0.0051369,
0.011884072,
0.01348769,
0.013667348,
-0.00032583883,
-0.028984893,
-0.019616038,
-0.013667348,
-0.031060945,
-0.03981763,
-0.031806193,
0.017420214,
0.03108756,
-0.030076152,
0.01608941,
0.021505779,
0.024420237,
-0.0026433077,
-0.014665451,
-0.002545161,
0.008656874,
0.006634054,
-0.011464869,
-0.010826084,
-0.002105996,
0.008437292,
0.011271902,
-0.0056625674,
0.018817557,
-0.005462947,
-0.012516203,
0.018617935,
-0.014226286,
0.003353624,
0.009887868,
0.009016192,
0.021732016,
-0.011857456,
-0.016315646,
-0.0055660843,
-0.032232054,
-0.015370776,
0.007192991,
-0.03441457,
0.027574241,
-0.01010745,
-0.018578012,
-0.01799246,
0.00682702,
-0.045753013,
-0.014173053,
-0.03899253,
-0.0008908064,
0.013733888,
-0.017060896,
-0.00045746358,
0.005988614,
0.031140793,
0.0062348126,
0.004701062,
-0.02008182,
-0.023169283,
0.011518101,
0.008696798,
-0.024380313,
-0.6272874,
-0.019642655,
0.014918303,
-0.019163566,
0.012309929,
0.038273897,
-0.0013557557,
-0.024287157,
-0.011977228,
0.010666387,
-0.03108756,
0.024526702,
0.02366168,
-0.0048075262,
-0.021559011,
-0.019150257,
-0.0069734086,
-0.014079898,
0.0021509107,
0.037129406,
-0.005519506,
0.0069933706,
0.012988639,
0.018218694,
0.01004091,
0.017193977,
-0.0061449837,
-0.009794711,
0.03151342,
0.040349953,
-0.033110384,
0.032631293,
0.0054596197,
-0.010007639,
0.052167483,
-0.003742884,
-0.019416418,
0.013500998,
0.013174951,
0.008962959,
-0.013514305,
0.008836533,
0.026416443,
-0.004691081,
-0.032631293,
0.023022894,
-0.002756426,
-0.005176824,
0.018990561,
-0.021811863,
0.0009781403,
0.0057157995,
-0.02379476,
-0.010080834,
0.01216354,
-0.0052367104,
0.013733888,
-0.004231954,
0.029437365,
-0.009601745,
0.02473963,
0.04021687,
-0.012030461,
-0.013507652,
0.006677305,
-0.0048341425,
-0.026110359,
0.010866008,
0.0069800625,
0.003779481,
0.03108756,
0.04561993,
0.0077053504,
-0.005027109,
0.027733937,
0.06036523,
-0.005093649,
0.022330876,
-0.010087488,
0.01010745,
0.011884072,
0.0190571,
-0.013946817,
-0.003198918,
0.027813785,
0.0056326245,
-0.04801538,
0.017819455,
-0.0024187346,
-0.025711117,
0.007179683,
-0.0024736302,
-0.020654066,
-0.031992506,
-0.0063013528,
0.009881213,
0.014745299,
0.012802326,
0.007751928,
0.0034900312,
-0.03718264,
0.009668285,
-0.03217882,
0.008330828,
0.01953619,
0.011691106,
-0.04205338,
-0.0049406067,
0.029171204,
-0.046950735,
0.01372058,
-0.0027880326,
-0.005569411,
-0.0009182542,
-0.0062048696,
-0.013214875,
-0.00002692797,
-0.022224413,
-0.005166843,
0.0008105423,
-0.015171156,
0.0027281465,
0.0025235354,
-0.0138270445,
0.029916454,
0.0075656157,
0.0020344653,
-0.03507997,
-0.014106513,
-0.009036154,
-0.022463957,
-0.017313749,
0.019296646,
-0.009521897,
0.014186362,
-0.030448776,
0.016661655,
0.021718707,
0.021346083,
-0.039365157,
-0.019256722,
-0.002706521,
0.018391699,
-0.0006961764,
-0.0012251707,
0.01635557,
-0.02265027,
-0.0014796867,
0.009135963,
0.00946201,
-0.0010230549,
-0.009495281,
-0.0006421125,
0.041547675,
0.007585578,
-0.007272839,
0.009109347,
-0.014572294,
0.0014098196,
-0.0138270445,
0.019230105,
-0.0036164576,
0.011039012,
0.0010080833,
-0.005466274,
-0.022211105,
-0.020454444,
-0.006331296,
-0.021119846,
-0.016235799,
-0.0077918526,
0.00591542,
-0.012136925,
0.009481972,
0.000620487,
0.001914693,
0.0052666534,
-0.007612194,
0.009628361,
-0.007539,
-0.010500037,
-0.01501146,
-0.0108194295,
0.0020394558,
0.008730069,
0.018484855,
0.020507677,
-0.012369815,
0.003875964,
0.02744116,
-0.02475294,
0.025697809,
-0.036410775,
0.010227222,
-0.009808019,
-0.02548488,
0.01825862,
-0.005060379,
0.0020477735,
0.03116741,
0.017486753,
-0.0352929,
0.057437465,
0.012928752,
0.030315695,
-0.03683663,
-0.0073992657,
-0.0061483104,
0.006434433,
-0.0032671217,
-0.02480617,
0.0124163935,
0.031619884,
-0.003390221,
0.008377406,
0.019429727,
-0.014838455,
-0.012762402,
-0.0031240603,
-0.0024969194,
0.01088597,
0.03002292,
0.020787146,
0.016475342,
0.0028778617,
0.015863173,
0.007552308,
0.025444956,
0.016102718,
-0.020467753,
-0.010160682,
0.020454444,
-0.0018914039,
-0.00088914286,
-0.014798531,
-0.0035998225,
-0.004611233,
-0.018058999,
0.02250388,
-0.0028346106,
0.021891711,
0.008257633,
0.019243414,
-0.0012933743,
-0.0021875077,
0.011005742,
0.015982946,
-0.011424945,
-0.009448702,
0.020055203,
-0.008337482,
0.0065774946,
-0.013128373,
0.009575129,
0.0071197967,
0.010706311,
0.03358947,
0.039125614,
0.026802376,
-0.0019945411,
0.017406905,
-0.010539961,
0.020374596,
0.011957266,
0.0065508783,
0.009668285,
-0.01335461,
-0.01446583,
0.0022407398,
0.0021675457,
-0.013906892,
0.011471523,
-0.003476723,
-0.03832713,
0.01751337,
-0.010067525,
0.030262463,
0.031194026,
0.022809966,
0.0032438326,
-0.0030641742,
-0.054456465,
0.0040888926,
0.018431624,
-0.0037628459,
-0.0043650344,
-0.015703477,
0.0138270445,
-0.0070466027,
0.020813761,
-0.010812775,
0.015477241,
-0.018484855,
-0.009468664,
-0.0010421852,
0.01125194,
0.02493925,
0.009116001,
0.020866994,
-0.009994332,
0.003742884,
-0.0024752938,
-0.011238633,
-0.013327993,
0.053498287,
0.027467776,
-0.012529512,
0.018205388,
0.014452522,
-0.030981097,
-0.004138798,
-0.009022845,
-0.017659757,
-0.020840377,
-0.0005040417,
-0.0022307588,
-0.0035499174,
0.00047534626,
0.03582522,
-0.033136997,
0.016076103,
-0.019868892,
-0.0003684661,
-0.019150257,
0.010453459,
0.03590507,
-0.0070532565,
-0.0108527,
0.0111920545,
0.010919239,
0.0115447175,
-0.021984868,
0.01757991,
-0.0023854647,
-0.005186805,
-0.013135027,
0.018232003,
0.019775735,
-0.028984893,
0.02744116,
-0.0034101831,
-0.025644576,
-0.006680632,
-0.009155925,
0.010792813,
0.02792025,
0.044874683,
0.023781452,
-0.0015778334,
-0.00539308,
-0.014146438,
0.004637849,
-0.009195849,
-0.01845824,
-0.03651724,
0.0111920545,
0.013441112,
0.01859132,
0.0028612267,
-0.015490549,
-0.003965793,
-0.01879094,
-0.009708209,
0.0038959263,
-0.0016410466,
0.0052733077,
0.030794784,
0.004218646,
0.017939227,
-0.003416837,
-0.015863173,
-0.00439165,
0.0060019223,
0.018817557,
0.027680706,
-0.012156887,
0.020055203,
-0.012582744,
0.024287157,
-0.034308106,
0.0049605686,
-0.032817606,
-0.0065808217,
-0.01044015,
0.007126451,
-0.022676885,
-0.012762402,
-0.014066589,
0.0005922074,
-0.026629372,
-0.0025501514,
-0.0074258815,
-0.009036154,
-0.01682135,
-0.02473963,
-0.02210464,
-0.00037615982,
-0.0068869065,
0.011890726,
0.0039524855,
0.024633165,
0.015903097,
0.013427803,
0.0106331175,
-0.004707716,
-0.013248146,
-0.010919239,
-0.020614142,
0.00077851984,
0.023834685,
0.011804224,
0.00033789923,
0.0015603667,
0.00070199865,
0.03454765,
-0.012942061,
0.009788057,
-0.007186337,
-0.0065142815,
-0.013088449,
0.012449663,
0.008290904,
-0.0073859575,
0.00019577362,
-0.005086995,
-0.021133155,
-0.0396047,
-0.009927792,
-0.004198684,
-0.0054496387,
-0.0029527196,
0.00090078736,
-0.015038076,
-0.015184464,
0.001358251,
-0.0056193164,
-0.0053664637,
-0.0029094685,
0.004245262,
0.02218449,
-0.0013391207,
0.02250388,
0.011391675,
-0.002987653,
0.04114843,
-0.010213914,
0.03151342,
-0.015064691,
-0.027547626,
-0.003004288,
0.0017766221,
-0.03191266,
-0.0169012,
-0.028000098,
-0.022344185,
0.031992506,
0.008077975,
-0.03209897,
-0.0039291964,
0.014492447,
-0.023608448,
-0.0017267171,
-0.024846096,
-0.001716736,
-0.009748133,
0.03358947,
0.00912931,
0.02177194,
0.017034281,
-0.038247284,
-0.01439929,
-0.00825098,
0.0015969637,
0.012276659,
-0.020121744,
0.0012750757,
-0.0106530795,
-0.024313774,
0.012629322,
-0.0374488,
0.0074791135,
0.0074192276,
0.033349928,
0.032365132,
0.036011532,
0.0044415556,
0.025258644,
0.034041945,
-0.00007189456,
-0.003975774,
-0.026589448,
-0.0018797595,
-0.0329773,
0.0097814035,
0.024659783,
0.007219607,
0.04359711,
-0.0521941,
0.019962046,
0.030076152,
-0.003812751,
-0.020640757,
0.011644527,
-0.020241516,
-0.041574292,
0.009821327,
0.031619884,
0.014439214,
-0.036384158,
-0.007079873,
0.021199694,
0.0070000244,
-0.0023788107,
-0.037076175,
0.026935456,
0.01514454,
0.03657047,
-0.015623629,
0.015663553,
0.013840353,
-0.025471572,
0.016927816,
-0.007818469,
0.008690145,
0.013747197,
0.030635089,
-0.013600809,
0.0013258127,
0.0062447935,
-0.021213003,
-0.0020377922,
-0.005210094,
-0.0156103205,
-0.00637122,
-0.009568474,
-0.02853242,
-0.016595116,
-0.041201666,
-0.002290645,
0.031593267,
-0.029437365,
0.03143357,
0.022290953,
-0.015796633,
0.0061383294,
-0.00021667138,
0.008410675,
-0.039232075,
0.02142593,
0.014133129,
-0.0253518,
-0.014306134,
0.020467753,
0.018830864,
-0.008936343,
0.044635136,
-0.020654066,
-0.017287133,
-0.02595066,
-0.0073859575,
0.014252902,
-0.015117924,
-0.019576114,
0.012123616,
0.0013324666,
-0.010972472,
-0.0012900473,
0.022809966,
-0.015583705,
0.00032417531,
-0.0118774185,
0.0050038197,
-0.0068203663,
-0.0048873746,
-0.010193952,
0.0025867487,
-0.034095176,
0.03819405,
-0.007825122,
-0.0066007837,
-0.009302314,
-0.002069399,
-0.0039591393,
0.023462059,
0.014731991,
0.028878428,
-0.002244067,
-0.00046328583,
0.008038051,
-0.001079614,
0.02366168,
-0.024247233,
-0.008404022,
0.039445005,
-0.008031397,
-0.010014294,
-0.00932893,
0.02291643,
0.0060318653,
-0.012103654,
-0.011458215,
-0.015304236,
-0.031273875,
-0.008676836,
0.02366168,
0.019030485,
0.005486236,
0.016368879,
-0.020188283,
-0.013174951,
-0.02690884,
0.006777115,
0.017287133,
-0.039232075,
-0.034893658,
-0.0052533452,
0.028213026,
0.012662592,
0.006281391,
-0.0071397587,
0.0053132316,
0.032205436,
-0.0009615053,
0.019003868,
0.014598911,
0.0056925104,
-0.038886067,
0.00033852304,
0.0040423144,
-0.010020948,
0.0017716317,
-0.00777189,
-0.00916258,
-0.019296646,
-0.0056492593,
0.0024237253,
-0.0033985386,
-0.022716809,
0.03577199,
-0.024979174,
0.021585627,
0.0019479631,
-0.023089435,
0.01078616,
0.025032407,
-0.003466742,
-0.018152155,
0.0070000244,
0.0025900756,
-0.013760504,
-0.029384134,
0.011265249,
-0.000024926567,
-0.01933657,
-0.015876481,
0.016036177,
-0.016328955,
-0.020574216,
-0.024074228,
-0.0039791013,
-0.014665451,
0.022078024,
0.016209181,
-0.013194913,
-0.007379303,
0.0023355596,
-0.013041871,
0.022304261,
-0.016395494,
-0.005220075,
-0.020986766,
-0.02623013,
-0.02704192,
-0.0034101831,
-0.026496291,
0.051182687,
0.026376517,
0.012323237,
-0.00865022,
0.008503832,
-0.035798606,
-0.020441135,
0.0051202653,
-0.008097937,
0.005868842,
0.017260516,
0.0030641742,
0.0126759,
-0.0061216946,
-0.009475319,
-0.0037195948,
0.0007618848,
0.0030824728,
0.005928728,
0.015836557,
0.011078936,
-0.03955147,
-0.015996253,
0.023222515,
0.0055760653,
-0.0083907135,
-0.006284718,
0.008823225,
0.011331789,
-0.01163122,
0.008197747,
0.00025825898,
-0.013201567,
0.036330927,
-0.03670355,
0.0038526752,
-0.015943022,
0.015623629,
-0.013214875,
0.022996278,
-0.0113983285,
0.0029161223,
-0.00090078736,
0.0016917835,
-0.009249082,
-0.002743118,
-0.014053281,
0.0065242625,
0.00097564503,
-0.0082044015,
0.012343199,
0.023182591,
-0.020853685,
-0.019283338,
-0.0051302463,
-0.025870813,
-0.01280898,
-0.0016610087,
-0.014186362,
-0.015676862,
0.008011435,
0.0126759,
-0.025271952,
-0.01277571,
-0.012529512,
-0.02177194,
-0.021213003,
0.027148385,
-0.010080834,
-0.0048208344,
-0.034521032,
-0.004664465,
-0.011511447,
-0.0050670328,
-0.002944402,
0.013387879,
-0.04719028,
-0.005805629,
0.01095251,
-0.014505754,
0.0040522953,
0.0014539025,
-0.010353648,
-0.020095127,
0.022317568,
0.16459373,
0.013973433,
0.0014547342,
0.0022523843,
-0.012715824,
-0.01020726,
0.014252902,
0.0035299554,
0.0017317076,
0.02792025,
0.040190253,
-0.014133129,
0.015397392,
0.0069601005,
0.0027913596,
-0.010573231,
-0.025564728,
0.0044415556,
-0.032684524,
-0.029650293,
0.024912635,
-0.020627448,
0.012915445,
-0.0024686398,
0.01683466,
-0.008224363,
-0.03055524,
-0.004255243,
0.012549474,
0.013840353,
0.006866944,
0.0012833932,
-0.010526652,
0.0035632255,
-0.027095152,
0.014292826,
-0.005186805,
-0.018271927,
-0.0037661728,
0.0064677033,
0.009488626,
0.0049738768,
-0.031806193,
0.011977228,
-0.014505754,
-0.007272839,
-0.0040356605,
-0.026576139,
-0.019030485,
0.030794784,
-0.044102818,
-0.00050861633,
-0.016448727,
0.023568524,
0.007678734,
-0.012848904,
0.009249082,
0.029889839,
-0.00096732756,
-0.012423048,
-0.0052367104,
0.0018431623,
-0.027081843,
0.025391724,
-0.031646498,
0.015330852,
0.004967223,
-0.003955812,
-0.0020294748,
-0.019017177,
-0.00686029,
-0.013341301,
0.025578037,
0.02697538,
0.0029061413,
-0.019216798,
0.03292407,
0.010160682,
0.010353648,
0.014212977,
0.0013058506,
-0.011870764,
-0.024846096,
0.021066613,
-0.0072462233,
-0.03758188,
0.010965818,
0.010673041,
-0.009575129,
-0.04503438,
0.0027198289,
0.008603643,
-0.017606525,
0.007878355,
0.022304261,
0.01095251,
-0.011757646,
-0.009734825,
-0.0048907017,
0.005971979,
-0.018578012,
0.079741724,
0.016568499,
0.0013898575,
-0.014425906,
-0.000113534144,
-0.025511496,
0.017273825,
-0.003307046,
0.0073926114,
-0.01189738,
-0.019629346,
-0.00535981,
-0.017593218,
-0.002310607,
0.014984843,
0.016116027,
-0.033562854,
0.023049511,
-0.0040855655,
0.0032238706,
-0.032338515,
0.013680656,
-0.0042585703,
-0.019975355,
0.010227222,
0.022703502,
0.002327242,
0.000114157956,
-0.043277718,
-0.010566577,
0.004657811,
0.0028678807,
-0.027387928,
-0.0035033394,
-0.0018414989,
0.0060019223,
-0.009102694,
-0.013135027,
0.01602287,
-0.009601745,
0.007898317,
0.03502674,
0.015716786,
-0.005961998,
-0.0010147374,
0.016102718,
-0.0021509107,
-0.032152206,
-0.0074125733,
-0.033349928,
-0.0052932696,
0.030581856,
-0.018058999,
0.0097814035,
-0.032205436,
-0.018218694,
-0.02460655,
0.0032205435,
0.00045787945,
-0.030848017,
0.00041670774,
0.021665474,
0.011597949,
-0.018112231,
-0.018112231,
-0.16651009,
0.013787121,
0.019789042,
-0.024420237,
0.0013474382,
-0.0044581904,
0.01277571,
0.0011236969,
-0.0060784435,
-0.0030358946,
0.017526677,
0.009422086,
0.0056758756,
-0.009475319,
-0.02197156,
0.009442048,
-0.03534613,
0.018564703,
0.0223708,
0.021106537,
-0.00023975251,
-0.03204574,
0.030502008,
-0.032950684,
0.005126919,
0.0071397587,
0.02853242,
-0.0006749667,
-0.005872169,
-0.009934446,
-0.012403085,
-0.018538088,
0.017313749,
-0.0035166473,
0.0138270445,
-0.0054396577,
-0.0018731054,
-0.014066589,
0.005542795,
0.013600809,
0.0083907135,
0.015863173,
0.018950637,
-0.006364566,
-0.008357444,
0.022756733,
0.018365083,
0.0092623895,
0.032152206,
-0.0017965842,
0.023515292,
0.0043849964,
0.019576114,
0.026589448,
0.03880622,
0.024619859,
0.0062481207,
0.021998176,
0.0018381719,
-0.029597063,
-0.014492447,
-0.018671168,
0.022357494,
-0.02555142,
-0.010034256,
-0.011105552,
-0.012482934,
0.005888804,
-0.038646523,
0.013747197,
-0.001066306,
0.0075656157,
0.0036464005,
-0.003366932,
0.024912635,
0.014173053,
-0.0010222232,
0.005858861,
-0.023927841,
-0.025258644,
-0.024699707,
0.017659757,
-0.005446312,
-0.03108756,
-0.012669246,
0.0016219163,
0.0205476,
0.030156,
-0.0090760775,
-0.018271927,
0.007625502,
-0.01683466,
0.023621757,
-0.004178722,
0.0077452743,
0.034654114,
-0.010227222,
0.0070066787,
-0.0190571,
0.01946965,
0.016142642,
-0.008856495,
-0.005116938,
0.0220381,
0.019616038,
0.00083882187,
0.012316583,
0.0040389877,
0.036810014,
-0.017287133,
0.013121719,
-0.0044215936,
0.006411144,
0.028079946,
0.011318481,
0.025125563,
0.0103004165,
0.021279542,
0.024659783,
-0.015517165,
0.08133869,
0.020627448,
-0.008244325,
0.026762452,
0.0022507207,
0.00269654,
-0.11370382,
-0.013201567,
-0.010020948,
0.016049486,
-0.004933953,
-0.001716736,
-0.008623605,
0.02143924,
-0.006364566,
0.018085614,
-0.00990783,
-0.011165438,
0.0083707515,
-0.005053725,
-0.0009606735,
-0.008829879,
0.0027148384,
0.014439214,
-0.038034353,
0.02372822,
-0.0027348006,
0.0074325358,
0.00086252677,
-0.0070199864,
-0.0064477413,
0.0047908914,
-0.04737659,
0.02379476,
0.009335584,
0.006061808,
-0.009122656,
-0.013567538,
0.0069401385,
0.008929689,
-0.009841289,
-0.019283338,
0.023555215,
-0.0020743895,
0.013800428,
-0.013787121,
-0.0014464167,
-0.0015736747,
0.0157434,
0.009854597,
0.01216354,
-0.01365404,
-0.027760554,
0.016887892,
0.030581856,
-0.011717722,
-0.032365132,
-0.0141996695,
-0.006308007,
-0.007658772,
0.026749143,
-0.0045446926,
-0.015171156,
0.020201592,
-0.0022473938,
0.02980999,
-0.007186337,
-0.011331789,
-0.013294724,
-0.017606525,
0.022889813,
-0.007878355,
-0.017393596,
-0.04197353,
0.018844172,
-0.008809917,
-0.01859132,
0.009741479,
-0.024513394,
-0.0042053377,
-0.021239618,
0.017606525,
-0.00542635,
-0.008031397,
0.01433275,
-0.025711117,
-0.02339552,
0.00015730508,
0.022384109,
-0.039258692,
0.010999088,
0.018072307,
0.010426843,
0.00439165,
0.022836583,
-0.009468664,
-0.012030461,
0.012962023,
-0.0013341302,
-0.009375508,
-0.020467753,
0.0070865266,
-0.004218646,
-0.003340316,
0.012596052,
0.02967691,
-0.035718758,
-0.022450648,
-0.04953249,
0.023009587,
0.018418316,
0.008324173,
0.01277571,
-0.014612218,
0.019762427,
-0.008423984,
0.003004288,
-0.023368903,
-0.011005742,
-0.018617935,
-0.008077975,
-0.011498139,
-0.022770042,
-0.023887916,
0.050118048,
0.0034733962,
0.02616359,
0.034068562,
-0.012596052,
0.028133178,
0.01743352,
0.009495281,
-0.018098922,
-0.01270917,
-0.026203513,
0.021000074,
-0.020787146,
-0.033083767,
-0.012962023,
-0.05738423,
-0.019749118,
-0.007891662,
-0.003396875,
-0.022344185,
-0.0033918845,
0.038486827,
0.019908816,
0.030182615,
0.007153067,
-0.029517213,
0.013667348,
0.016408803,
-0.0029211128,
0.0013524287,
-0.038513444,
-0.014944919,
0.0027730612,
0.004651157,
0.023768144,
0.008510486,
0.021013381,
-0.019828968,
-0.0268423,
0.00939547,
0.0138270445,
-0.012828942,
-0.003466742,
-0.017154053,
0.005050398,
-0.0034833772,
-0.018578012,
0.006813712,
-0.0026532887,
-0.020055203,
-0.04048303,
0.0027580895,
0.0072794934,
-0.019655962,
-0.028372724,
0.007179683,
0.018910713,
-0.008211056,
0.0016086083,
0.017885994,
-0.024367005,
-0.019323261,
0.0026449712,
0.00015855272,
0.023741528,
0.0030425487,
-0.007678734,
0.015796633,
0.018578012,
-0.006604111,
-0.009402124,
0.0096150525,
0.012436355,
0.017287133,
-0.019576114,
0.028372724,
0.0011528082,
0.01365404,
-0.0074524977,
0.014984843,
-0.0025401704,
0.0053132316,
0.0048574316,
0.034334723,
0.0025817582,
0.010307071,
0.0065209353,
-0.0057024914,
-0.02475294,
0.038699754,
-0.033296693,
-0.02927767,
-0.010240531,
-0.011484832,
0.02561796,
0.018498164,
0.0031007712,
0.0030758188,
0.004671119,
0.006690613,
0.0064610494,
0.0013083458,
0.010872662,
0.035452597,
0.006780442,
0.0094287405,
0.00916258,
0.0072994553,
0.018604629,
-0.0029593734,
0.025657885,
-0.03103433,
-0.0015653572,
-0.014439214,
-0.0036330926,
0.0016086083,
-0.036277693,
0.0019429725,
0.016448727,
-0.03183281,
0.03143357,
0.030315695,
-0.035319515,
0.076175176,
0.0011627893,
0.014359366,
-0.0064177983,
-0.031114178,
0.012276659,
-0.01683466,
0.019868892,
-0.015650244,
-0.0286655,
0.019110333,
-0.018697783,
0.01724721,
-0.02583089,
-0.031060945,
0.0396047,
0.0056991642,
0.037714962,
-0.004977204,
-0.011218671,
0.010200606,
-0.013075141,
0.011777608,
0.011025704,
-0.017633142,
0.008364098,
0.035878453,
0.00011363811,
0.0065708407,
-0.018671168,
-0.000047435853,
-0.0044415556,
-0.02460655,
-0.007698696,
0.005512852,
-0.016621731,
-0.015849866,
-0.014731991,
0.0062680827,
0.013414496,
0.001987887,
0.010706311,
-0.0069467924,
-0.01071962,
-0.016754812,
0.0015379094,
-0.036783397,
0.0053731175,
-0.015370776
] |
Fibroblast growth factors (FGFs) have mitogenic activity toward a wide variety of cells of mesenchymal, neuronal, and epithelial origin and regulate events in normal embryonic development, angiogenesis, wound repair, and neoplasia. FGF-2 is expressed in many normal adult tissues and can regulate migration and replication of intestinal epithelial cells in culture. However, little is known about the effects of FGF-2 on intestinal epithelial stem cells during either normal epithelial renewal or regeneration of a functional epithelium after injury. In this study, we investigated the expression of FGF-2 in | [
-0.0065061315,
-0.0013724649,
-0.016632315,
-0.010528043,
-0.014041819,
-0.012102268,
-0.041394804,
0.017150415,
-0.005031541,
-0.012102268,
0.026516056,
-0.004098298,
0.0013334414,
0.023194905,
-0.028615022,
0.007472586,
0.033184923,
0.013722989,
-0.022397831,
0.045061354,
-0.012049129,
0.030660849,
0.002236794,
-0.022437684,
-0.035735566,
0.015463271,
-0.0020823604,
-0.035337027,
-0.0050780373,
-0.032122154,
0.01514444,
-0.016632315,
-0.008216524,
0.014028534,
0.0038326061,
0.006698758,
-0.0010112899,
-0.0007277468,
0.015237433,
0.008880753,
0.03031545,
-0.0016829923,
0.0050016507,
-0.007558936,
-0.008156743,
-0.010893369,
0.020126164,
-0.020498132,
-0.016207209,
0.016539322,
0.009631333,
-0.0004973421,
-0.014081673,
0.0064961677,
-0.0061740163,
-0.010501474,
0.016366623,
0.0015078017,
-0.004961797,
-0.021029517,
-0.005164387,
0.014852179,
-0.009119876,
-0.0051776716,
-0.013244743,
0.022145422,
-0.0001671991,
0.01748253,
0.005971426,
0.0012163708,
0.022809653,
0.019634634,
-0.020816963,
-0.019368943,
0.0135835,
-0.01078045,
-0.018106906,
-0.009119876,
-0.014254373,
0.001609927,
0.0046363245,
-0.0276851,
-0.016207209,
0.034433674,
-0.0047326377,
0.011637307,
-0.009319144,
0.007950831,
0.009511772,
0.008522069,
0.030660849,
0.03491192,
0.023991982,
0.020059742,
-0.012387887,
0.010494832,
0.0034141415,
0.02112251,
0.027313132,
-0.025200881,
-0.015542978,
0.016114216,
0.015728964,
-0.012547302,
-0.03254726,
-0.0009656241,
0.032255,
-0.004001985,
0.033875722,
-0.014347364,
-0.03554958,
0.02176017,
0.0039887,
-0.026489487,
0.018332744,
0.0074393745,
0.03592155,
0.014347364,
-0.010421766,
-0.012839563,
0.011710372,
0.009405495,
0.023221476,
-0.025360296,
0.02667547,
0.0034207837,
0.0054466845,
0.0014961777,
-0.033131786,
0.0017037495,
0.01667217,
0.0022467575,
0.013563573,
0.020551272,
-0.040013205,
-0.006346716,
-0.018877411,
-0.015901662,
-0.021388201,
-0.032095585,
0.005390225,
0.01153103,
-0.034407105,
0.006210549,
-0.028827576,
0.014480211,
0.029943481,
0.016366623,
0.03491192,
-0.015157725,
0.01627363,
-0.037781395,
0.0081501,
0.0032148724,
-0.009073379,
0.004985045,
0.03135165,
0.033424046,
-0.017362969,
-0.0047990605,
0.0016381568,
-0.027658531,
0.01300562,
0.0041481154,
0.0041348306,
0.017044138,
-0.0055728885,
0.009053453,
0.000075089105,
-0.025254019,
0.013802696,
0.031059388,
-0.029465236,
0.019714342,
0.0057987263,
0.0020873423,
-0.011497819,
0.0138558345,
-0.013184963,
-0.02326133,
-0.013284597,
0.02557285,
0.013570216,
-0.009319144,
-0.018080337,
-0.0060378495,
0.03491192,
-0.007293244,
-0.0092925755,
-0.028535314,
-0.01667217,
0.010096294,
0.008216524,
-0.0147193335,
-0.61470485,
-0.02927925,
0.039003577,
-0.018492159,
0.026755178,
0.023620013,
0.00997009,
-0.00716704,
-0.007884408,
-0.011378258,
-0.014546634,
0.014945172,
0.0035536296,
0.00089172856,
-0.000115306146,
-0.024629643,
-0.021707032,
-0.027167,
0.014121527,
-0.00027357967,
-0.01792092,
0.0007123865,
-0.0054400424,
0.03159077,
-0.005237452,
0.027445978,
0.021640608,
-0.030076327,
0.0018000628,
0.042484142,
-0.04880761,
0.0382065,
-0.0030139429,
-0.007844554,
0.042457573,
0.012819636,
-0.0016672169,
0.01600794,
0.010395197,
0.029544944,
-0.00953834,
-0.004201254,
0.026542624,
0.00030782903,
-0.01418795,
0.008854183,
0.020551272,
0.020989664,
0.0049153008,
-0.0029757498,
-0.0010320471,
0.02901356,
-0.031511065,
-0.014068388,
0.040358607,
0.020710686,
0.029544944,
0.008522069,
0.014028534,
0.0010561255,
0.0074858703,
0.040544588,
-0.019461934,
-0.014028534,
0.017097276,
0.025811972,
0.0029890344,
0.00806375,
0.010727312,
0.009319144,
0.022729944,
0.039056715,
0.013789412,
0.014081673,
0.027445978,
0.054121446,
-0.0019262666,
0.028880714,
-0.0106210355,
-0.002681828,
0.007392878,
-0.0007891881,
-0.0028678123,
0.019647919,
0.0068681366,
-0.0014123187,
-0.036665488,
0.0108734425,
-0.011026216,
0.0142145185,
0.0071603977,
-0.013012263,
-0.007930905,
-0.068335965,
-0.0064795623,
0.019488504,
-0.011504461,
0.023713006,
0.0011624022,
-0.024350666,
0.0094719175,
-0.012872774,
0.020963093,
0.016260346,
0.0053603346,
0.005991353,
-0.05563589,
0.016658884,
0.03002319,
-0.036585778,
0.0048090243,
-0.008362654,
-0.013111897,
-0.022902645,
-0.009976733,
-0.025413433,
0.00075390085,
-0.014985025,
-0.024988327,
-0.017934205,
0.004204575,
-0.022650238,
-0.0016315145,
0.0017319793,
0.03926927,
0.008402508,
-0.011159061,
-0.0073264553,
-0.0032563868,
-0.017681798,
-0.0021786739,
-0.013543647,
0.0163002,
-0.021800023,
0.021042801,
-0.0068415673,
0.026755178,
-0.008329442,
0.0071404707,
-0.032786384,
-0.029784067,
0.0041614,
0.045087922,
-0.03695775,
0.004410486,
-0.0056193843,
-0.0227698,
0.0073795933,
0.008475573,
0.0011316816,
-0.012733286,
-0.0016406478,
-0.012348033,
0.012673506,
0.019488504,
-0.014613057,
0.0049053375,
-0.021773454,
0.008196596,
-0.013603427,
-0.0168183,
0.010388555,
-0.0219063,
-0.0055762096,
-0.0030189247,
-0.00029475198,
-0.029491805,
-0.0018482195,
0.0073795933,
-0.03621381,
-0.015503124,
-0.0019661204,
-0.005254058,
0.01011622,
-0.009571552,
0.009385568,
-0.008362654,
0.0072866012,
-0.016167354,
0.0034805643,
0.012627009,
-0.028854145,
0.0074260896,
0.0045964704,
0.024350666,
0.011637307,
0.024231104,
0.0064231027,
-0.006409818,
0.018053766,
-0.015343709,
0.0014405485,
-0.021481194,
0.016247062,
0.00097641785,
-0.026489487,
-0.0046197185,
-0.001164893,
-0.011192272,
0.028907282,
0.023606729,
-0.041315097,
0.015024879,
0.0064197816,
0.015848525,
-0.017323114,
-0.019289235,
-0.011902999,
0.016898008,
0.01028892,
-0.012447667,
0.010973077,
-0.01514444,
-0.0025888358,
0.0073530246,
-0.025493141,
-0.01514444,
-0.017203553,
-0.008515427,
-0.0049750814,
-0.0065758754,
-0.0028827575,
-0.0064064967,
0.021959439,
-0.0006770993,
0.018253036,
0.0048189876,
0.009066737,
-0.003935562,
-0.017402822,
0.0041580787,
0.013450654,
0.00971104,
-0.004231144,
0.0016771804,
0.010853516,
0.016220493,
-0.017097276,
0.052288175,
-0.006360001,
0.023739574,
0.0019760837,
0.0124543095,
0.0031434677,
-0.014772472,
-0.032201864,
0.020059742,
-0.004676178,
-0.0077847736,
0.0074194474,
0.0092925755,
0.03031545,
-0.0073795933,
-0.004184648,
0.004320815,
0.0041547576,
0.014041819,
0.014453641,
0.0073131705,
0.017004283,
0.0053802617,
-0.0010162716,
-0.009744252,
-0.015635971,
-0.0009606424,
0.020073026,
0.012766497,
-0.00572234,
-0.031856462,
-0.012088983,
-0.018850842,
-0.0052872696,
0.023221476,
-0.027153715,
0.010308847,
-0.013470581,
0.03980065,
-0.0033228097,
-0.016844869,
0.018545298,
0.0142145185,
-0.03560272,
0.03164391,
0.007592147,
-0.011152419,
0.01846559,
-0.008103604,
0.0007547312,
-0.003942204,
-0.016725307,
0.0026751857,
0.012932555,
-0.00774492,
-0.017960776,
-0.01956821,
0.0013683134,
-0.00690799,
-0.016140785,
0.024616359,
0.0048820893,
-0.0045034783,
-0.0034373894,
-0.008023896,
-0.003962131,
0.020033171,
0.007990685,
-0.010063082,
-0.00838258,
-0.012613725,
-0.010667531,
-0.0061740163,
0.009810675,
0.0031716975,
-0.006536022,
-0.012945839,
-0.004948512,
0.007751562,
-0.010381913,
0.04115568,
0.0006638147,
-0.0027233423,
-0.022065716,
-0.006785108,
0.002326465,
0.014453641,
0.024124827,
0.01797406,
0.008189954,
0.005293912,
-0.014905318,
0.013975396,
0.00774492,
-0.004961797,
-0.033742875,
0.006476241,
0.0012811333,
0.0059747472,
-0.016406476,
-0.005293912,
0.0028478855,
-0.010660889,
-0.017243406,
-0.02407169,
0.0094719175,
-0.0037761466,
0.013058758,
0.04150108,
0.035044767,
0.00017228462,
0.0040418385,
-0.009591479,
0.03132508,
-0.021853162,
-0.011823291,
-0.012228471,
0.016353339,
0.010760523,
0.014958456,
-0.0119162835,
-0.019196242,
-0.00661905,
-0.010454978,
0.00078005495,
0.004961797,
0.009525056,
0.00872798,
0.00087263196,
-0.013038832,
0.006549306,
-0.013543647,
-0.015290571,
-0.009046811,
-0.0166456,
-0.021441339,
-0.0039023503,
-0.03132508,
-0.005137818,
-0.017881067,
0.014865464,
-0.0051544234,
0.002568909,
-0.00045790346,
-0.009518414,
-0.008096962,
0.0073530246,
-0.024510082,
0.017615376,
-0.01922281,
0.0018249715,
-0.010249066,
-0.0013749558,
-0.01381598,
-0.009544983,
0.0005990523,
-0.005562925,
-0.026688755,
-0.02933239,
-0.011391542,
0.008488857,
0.036426365,
0.005592815,
-0.0042477497,
-0.020019887,
0.009843886,
0.024576504,
-0.03034202,
-0.022517392,
-0.006247082,
-0.008057108,
0.01531714,
-0.005503144,
-0.012660221,
-0.017150415,
-0.019926894,
0.024138112,
-0.014347364,
0.010660889,
-0.013922257,
-0.014055103,
0.014227803,
0.02601124,
-0.016605746,
0.022676807,
0.0018598436,
-0.00939221,
-0.017562237,
-0.019953465,
-0.022185277,
-0.004187969,
0.009451991,
0.0019096608,
-0.00071819854,
-0.028482176,
-0.0020225798,
0.006074382,
-0.0007057442,
0.012268325,
-0.0023796035,
0.0057455883,
0.023208192,
-0.001748585,
0.006280293,
0.027738238,
-0.0126336515,
0.0077117085,
-0.0103354165,
0.03254726,
-0.027711669,
-0.024310812,
-0.015516409,
0.011318477,
-0.023194905,
-0.024842195,
-0.0022085642,
-0.0022666843,
0.0273397,
0.010521401,
-0.008621703,
-0.021481194,
-0.008933892,
-0.023620013,
0.009119876,
0.006625693,
-0.017402822,
-0.014094957,
-0.0008643291,
0.019687772,
-0.01942208,
0.012248399,
-0.03791424,
0.0012039166,
0.009206225,
0.018080337,
0.0034739221,
-0.01450678,
0.01326467,
-0.01161738,
0.00502822,
-0.02288936,
-0.038605038,
-0.017827928,
-0.019727627,
0.0399335,
0.032414418,
0.041235387,
0.020524703,
0.020498132,
0.002010956,
0.0051942775,
0.017881067,
-0.015463271,
0.00933243,
-0.021919584,
0.02864159,
0.0038093582,
0.003779468,
0.029890344,
-0.016034508,
0.0018448983,
0.022397831,
-0.0020557914,
-0.002826298,
0.0056459536,
-0.030421726,
-0.037834533,
0.021826593,
-0.011657233,
0.022969067,
-0.029438667,
-0.0037595409,
0.012587155,
0.008475573,
-0.004958476,
0.020059742,
0.028455606,
-0.0036565852,
0.023991982,
-0.009611405,
-0.00005531789,
-0.0017103918,
-0.019860473,
0.018000629,
-0.03597469,
0.016605746,
0.0044171284,
0.0050946428,
-0.015622686,
-0.013058758,
0.0041547576,
0.0038658178,
-0.01667217,
-0.025878394,
-0.011683803,
-0.015250717,
-0.014254373,
-0.023420744,
-0.025612703,
-0.035708997,
-0.0034805643,
0.010282278,
-0.03323806,
0.024802342,
0.019754196,
-0.012879416,
0.025785403,
-0.014931886,
0.018146759,
-0.021640608,
0.0133510195,
0.018359313,
0.005851865,
-0.029040128,
-0.0053736195,
-0.012700074,
0.0016995982,
0.04144794,
0.007990685,
0.0104416935,
-0.03568243,
-0.01566254,
0.008694769,
-0.002751572,
-0.020803679,
0.019368943,
0.010275636,
0.0015136137,
-0.009432063,
0.0030737235,
-0.04187305,
0.021388201,
0.00419129,
0.01381598,
0.004453661,
0.0047226744,
-0.03031545,
0.030820265,
-0.0015991334,
0.015356994,
0.015224148,
0.0004317494,
-0.027392838,
-0.021640608,
-0.013975396,
0.020033171,
-0.006529379,
0.012314822,
-0.014559918,
0.018332744,
0.02126864,
-0.010826946,
0.0068017137,
0.012912628,
0.011756868,
0.03693118,
-0.004184648,
-0.004832272,
-0.002927593,
0.015888378,
0.019289235,
-0.020763826,
-0.0032464233,
0.0013085328,
-0.02832276,
-0.005562925,
0.031856462,
0.01861172,
-0.005117891,
0.02967779,
-0.034699365,
-0.006426424,
-0.03132508,
-0.022862792,
0.023845851,
-0.02508132,
-0.031112526,
0.0015601099,
0.025639271,
0.01730983,
-0.005503144,
-0.00800397,
0.017190268,
0.029040128,
-0.010760523,
0.014108242,
0.01777479,
0.0082497345,
-0.021693747,
0.0045134416,
-0.008402508,
-0.017562237,
-0.0024576504,
-0.030899972,
-0.031192234,
0.0017618696,
-0.0019727626,
0.033105217,
-0.0054334,
-0.026423063,
0.017362969,
0.0004960967,
0.018492159,
-0.004138152,
0.006426424,
-0.003126862,
0.022052431,
-0.0032929194,
0.007193609,
-0.005024899,
-0.00257223,
-0.0009515092,
-0.01326467,
0.004048481,
0.0041248673,
-0.008820972,
-0.012965767,
-0.0006671359,
-0.020564556,
-0.015264002,
-0.013218174,
0.00473928,
-0.018186614,
0.016446332,
0.011132492,
-0.017469244,
-0.013098612,
0.012387887,
-0.009996659,
0.03791424,
-0.0018415772,
-0.0025024859,
-0.0168183,
-0.02901356,
-0.019342372,
0.014559918,
-0.005516429,
0.041740205,
0.003372627,
0.0055263923,
-0.019355658,
-0.01586181,
-0.042005897,
-0.03499163,
0.026715325,
0.018346028,
-0.011099281,
0.0048953737,
-0.014373934,
0.007857839,
-0.010096294,
0.009857171,
-0.014546634,
-0.0016514414,
0.008880753,
-0.029252682,
0.016898008,
-0.006071061,
-0.03254726,
-0.03461966,
0.030607712,
0.0019694415,
-0.008840899,
-0.010853516,
-0.01841245,
0.027007585,
-0.032494124,
0.0051843137,
0.04445026,
0.018372597,
0.02291593,
-0.028349329,
-0.012593797,
-0.0046097552,
0.002522413,
-0.0175091,
-0.006828283,
-0.009571552,
0.007545651,
0.0053603346,
-0.008402508,
0.012434383,
-0.004456982,
-0.005596136,
0.03857847,
-0.0014023553,
0.012832921,
0.009080022,
0.029146405,
0.013297881,
-0.014520064,
-0.00072608626,
-0.01866486,
-0.011072711,
0.0224244,
0.0074925125,
-0.03334434,
-0.0004745092,
-0.00329458,
-0.034779076,
-0.012945839,
0.009279291,
-0.024576504,
0.0007314831,
-0.0013151751,
-0.0036001257,
-0.009664544,
-0.026569193,
-0.0027798018,
-0.009837244,
-0.02687474,
-0.013776127,
-0.02057784,
-0.009637975,
-0.00601128,
0.0020009924,
0.0050780373,
-0.0021521046,
0.009212868,
-0.015556263,
-0.005602779,
0.015224148,
0.17588806,
-0.00783127,
0.011643949,
-0.0032696715,
0.015556263,
-0.014028534,
0.040544588,
0.008588492,
-0.01433408,
-0.0013126843,
0.00505811,
-0.0008282116,
-0.010687458,
0.0026917914,
0.025200881,
-0.005586173,
-0.028694728,
0.0032032484,
-0.018346028,
-0.009491844,
0.021640608,
-0.01922281,
0.020205872,
0.0028661517,
0.032440986,
0.0112321265,
-0.047027472,
-0.008894037,
0.021242071,
-0.001971102,
-0.002190298,
0.010043155,
-0.012580513,
0.009259364,
-0.0076652123,
0.0076851393,
-0.009996659,
-0.0033543608,
-0.0069611287,
-0.016977714,
0.024377236,
-0.007984043,
-0.03403514,
0.012394529,
-0.0024642928,
0.032069016,
-0.021746885,
0.00765857,
0.010853516,
0.007632001,
-0.05563589,
0.0012255041,
0.015768817,
0.017708367,
-0.00040248176,
-0.011145777,
0.017216837,
0.010401839,
0.0074393745,
0.022052431,
-0.009890382,
0.012308179,
-0.01179008,
0.0154367015,
-0.031165665,
0.00913316,
-0.018571867,
0.00024327417,
-0.00915973,
-0.022610383,
0.009804033,
0.009126518,
-0.018067053,
0.025121173,
-0.023168337,
-0.010541327,
0.00800397,
-0.011092639,
0.0025157705,
0.02864159,
0.01748253,
-0.0047027473,
-0.02569241,
0.011066069,
-0.014148096,
-0.03238785,
0.021707032,
0.018970404,
-0.007811343,
-0.03262697,
0.018598435,
-0.010308847,
-0.0129923355,
0.0061341627,
0.013882403,
-0.031165665,
-0.018452305,
0.023938844,
-0.008156743,
-0.00095067895,
-0.04949841,
0.08199253,
0.010880085,
0.003453995,
-0.01962135,
0.011670519,
-0.005044826,
0.00003168065,
-0.019302519,
0.0005205901,
-0.008993672,
-0.011690445,
0.0013417443,
-0.011079354,
-0.00881433,
0.0023198228,
0.013125182,
-0.008548638,
0.024629643,
-0.024775773,
-0.0329458,
-0.017854499,
0.01910325,
0.03323806,
-0.023952128,
0.009877098,
-0.021866446,
0.007592147,
0.00091248576,
-0.039295837,
-0.018970404,
-0.015596117,
-0.0051909564,
0.023088628,
0.032148723,
0.020949809,
0.020365287,
0.0032497444,
-0.015449986,
0.026157372,
-0.011105923,
-0.021786738,
0.0164729,
0.0047060684,
0.007186967,
0.012553944,
0.015742248,
0.01947522,
-0.008329442,
-0.027871083,
-0.018452305,
-0.02161404,
0.011152419,
0.003716366,
0.03063428,
-0.01586181,
-0.023460599,
-0.032520693,
0.029518373,
-0.023115199,
-0.030501435,
0.008714695,
0.0040816925,
-0.019541642,
-0.0071803248,
-0.0212155,
-0.16536666,
0.010667531,
-0.0005513108,
-0.011477891,
0.025200881,
0.008170027,
-0.014440357,
-0.012088983,
0.0018565224,
0.02965122,
0.045592736,
-0.012308179,
-0.037967376,
-0.02176017,
0.00015007443,
0.016286915,
-0.00033107706,
0.02684817,
0.011484534,
0.022942498,
0.020684117,
-0.017495815,
0.0075987894,
0.0011715353,
0.020856816,
-0.0124543095,
0.011604096,
-0.0068614944,
-0.012427741,
-0.015410133,
0.0116638765,
-0.0006443029,
0.044317417,
0.007857839,
0.02025901,
-0.010043155,
-0.007851196,
-0.0014380576,
-0.004935228,
0.02763196,
0.017562237,
0.019754196,
0.00855528,
0.0032613685,
-0.011723657,
0.03525732,
-0.0023862456,
-0.014254373,
0.027313132,
-0.019887041,
0.04649609,
-0.005254058,
0.0010611071,
0.022690091,
0.013151751,
0.026808316,
0.00445034,
-0.0108003775,
0.007944189,
-0.016379908,
0.011956138,
0.010176001,
0.029119836,
-0.005044826,
-0.003918956,
-0.031750187,
-0.005164387,
0.0102623515,
-0.023487167,
0.0044835513,
-0.02866816,
-0.009631333,
0.021893015,
-0.02736627,
0.056592382,
0.014759187,
-0.0067319693,
-0.0073795933,
-0.004669536,
0.015901662,
-0.03459309,
0.015994655,
-0.02441709,
-0.008661557,
-0.01176351,
0.018704712,
0.019488504,
0.028216483,
-0.010169359,
-0.0038425697,
0.037010886,
-0.018292889,
0.0036333373,
-0.0060179224,
0.043732893,
0.02468278,
0.011969422,
0.0012562247,
-0.008820972,
0.006901348,
0.03626695,
-0.001520256,
-0.021056086,
0.017044138,
0.033052076,
-0.0034207837,
-0.014121527,
0.018146759,
0.04742601,
-0.018106906,
-0.007525724,
-0.0019163031,
0.0018415772,
0.009066737,
0.015277286,
0.03353032,
0.0019295877,
0.013683135,
0.023686437,
-0.04676178,
0.053536925,
0.004875447,
0.012826278,
0.051623944,
-0.0008634988,
-0.025745548,
-0.13135809,
-0.011258696,
0.009704398,
0.024908619,
-0.0039920215,
0.010282278,
-0.011271981,
0.0024194573,
0.0011922925,
0.0161275,
-0.028083637,
-0.0038624965,
0.013962111,
0.0009232795,
0.028535314,
0.00973761,
0.0036333373,
0.0043042093,
-0.026688755,
0.035124473,
0.00068830815,
0.021667177,
-0.02999662,
-0.017362969,
-0.016247062,
0.025214165,
-0.040943127,
0.02436395,
0.008588492,
0.01112585,
0.009511772,
-0.016990999,
0.049232718,
-0.002661901,
-0.015476556,
-0.02092324,
0.013012263,
-0.01667217,
0.011132492,
-0.03531046,
-0.011046142,
0.0055728885,
0.021534331,
-0.008170027,
-0.017376253,
-0.0049750814,
-0.026144087,
-0.0027316452,
0.03366317,
-0.03390229,
-0.04251071,
-0.0069544865,
-0.025161026,
-0.018983688,
0.018678144,
0.008156743,
-0.00008090112,
0.0051776716,
0.0150780175,
0.0059348936,
-0.017123844,
-0.0009216189,
-0.028880714,
-0.014387218,
0.008269661,
0.00044461884,
-0.029119836,
-0.035097905,
0.023022207,
-0.021786738,
0.005542998,
0.0033543608,
-0.014373934,
0.004201254,
-0.021308493,
0.0020939845,
0.022809653,
-0.004111583,
-0.004696105,
-0.02439052,
-0.018903982,
-0.028269622,
0.01627363,
-0.020059742,
0.035443306,
0.002841243,
0.01661903,
-0.014892033,
0.025851825,
-0.0033161675,
-0.00913316,
0.040305465,
0.030899972,
-0.009053453,
-0.0015019898,
0.011205558,
-0.007412805,
0.0039687734,
0.023008922,
0.010454978,
-0.023659866,
-0.012733286,
-0.05770829,
0.0036399795,
0.008847541,
0.0045964704,
0.005599458,
-0.0045067994,
0.0003734217,
-0.011956138,
0.003630016,
0.0033709665,
-0.018625004,
0.021640608,
-0.004852199,
-0.0166456,
-0.032733247,
-0.023141768,
0.043042094,
0.0037329716,
0.020444995,
0.029943481,
0.0011507781,
-0.002037525,
0.0017170341,
-0.0065958025,
-0.021242071,
0.0054699327,
-0.027087294,
-0.0057389457,
-0.0027382874,
-0.0057057342,
0.018837558,
-0.04710718,
-0.030395158,
-0.009996659,
-0.007552293,
-0.036798332,
0.0019013579,
0.03459309,
0.0119162835,
0.030049758,
-0.006715364,
-0.0126336515,
0.040757142,
0.010342059,
0.013284597,
0.002240115,
-0.019953465,
-0.00933243,
0.011863145,
-0.0005554622,
0.012142122,
0.005503144,
-0.003095311,
-0.0066589043,
0.007014267,
-0.007937547,
0.0023281255,
0.002705076,
-0.010275636,
-0.0054201153,
0.014985025,
-0.001537692,
0.017296545,
0.0019146425,
-0.0031484494,
-0.005051468,
-0.023606729,
-0.0037993947,
0.013895689,
-0.043068662,
-0.033078644,
-0.01947522,
0.008488857,
0.0009332429,
0.0006335092,
0.025147742,
-0.022012576,
-0.018000629,
-0.009823959,
0.046336673,
0.030713988,
-0.011285265,
-0.026130803,
0.016951146,
0.019687772,
0.0010669192,
-0.013211532,
0.01548984,
0.013390874,
-0.010601108,
-0.013709704,
0.007904335,
0.008933892,
0.0013267992,
0.00032422718,
0.019953465,
-0.030687418,
0.028747868,
0.007299886,
0.02638321,
-0.004400523,
0.013390874,
0.021494478,
0.012009275,
-0.017562237,
0.016313486,
-0.019581495,
-0.021826593,
-0.023965413,
0.0012313161,
-0.0027117184,
0.023354322,
-0.002482559,
-0.00051477813,
-0.0115575995,
0.004586507,
0.0022666843,
-0.0019528357,
0.0077050664,
0.0283759,
0.0051311757,
0.0006247912,
-0.0092195105,
-0.010973077,
0.02323476,
-0.0035801989,
0.029810635,
0.0038558543,
0.009126518,
0.001352538,
0.018160043,
0.0012230132,
-0.020511417,
-0.01748253,
0.014732618,
-0.01566254,
-0.0044603036,
0.028907282,
-0.036134105,
0.08332099,
0.002205243,
-0.032255,
0.013038832,
-0.011139135,
0.008515427,
-0.016220493,
0.022982353,
-0.043600045,
-0.025532994,
0.0036765123,
-0.044928506,
0.023646582,
-0.03201588,
-0.014706049,
0.018452305,
-0.018744566,
0.011165704,
0.0061374838,
0.02488205,
0.002228491,
-0.018545298,
0.009033526,
0.03132508,
-0.03732972,
0.010760523,
0.029704358,
-0.0007049139,
0.008721338,
-0.038047086,
-0.01878442,
0.002759875,
-0.038498763,
0.010687458,
0.0087877605,
-0.012334748,
-0.005566246,
-0.04155422,
0.01881099,
0.0319096,
-0.016180638,
0.011650591,
-0.010906654,
-0.020564556,
-0.0075987894,
-0.033131786,
-0.03624038,
-0.012739928,
-0.0067784656
] |
The use of caspase inhibitors has revealed the existence of alternative backup cell death programs for apoptosis. The broad-spectrum caspase inhibitor zVAD-fmk modulates the three major types of cell death. Addition of zVAD-fmk blocks apoptotic cell death, sensitizes cells to necrotic cell death, and induces autophagic cell death. Several studies have shown a crucial role for the kinase RIP1 and the adenosine nucleotide translocator (ANT)-cyclophilin D (CypD) complex in necrotic cell death. The underlying mechanism of zVAD-fmk-mediated sensit | [
-0.020831022,
-0.011139001,
-0.006685448,
-0.014783747,
-0.030113524,
0.043327436,
-0.035300802,
-0.014428828,
-0.005603627,
-0.0041532363,
0.03303478,
0.022878634,
0.020107534,
0.0021875305,
-0.017486593,
0.007275842,
0.027984008,
0.010217575,
0.0049142647,
0.004685615,
0.003637921,
0.043163627,
-0.0036242704,
-0.02672814,
0.0052725966,
0.042180773,
-0.02614116,
-0.037321113,
-0.009398531,
-0.007535206,
0.011882965,
-0.022346254,
0.0016457668,
-0.014961206,
0.005624103,
0.0005438965,
-0.009623769,
-0.034317948,
0.0011219198,
0.004241966,
0.035027787,
-0.0231926,
-0.0013812839,
-0.007118859,
-0.011821537,
0.0029980429,
-0.008647741,
-0.010238051,
-0.0121423295,
0.013234388,
0.010203925,
0.0012609867,
0.007275842,
0.010838684,
0.014551684,
-0.03224304,
0.0049688676,
-0.0054398184,
0.0076375864,
-0.016312629,
-0.025595129,
-0.00035918498,
-0.017158974,
0.026755443,
0.023083394,
0.015138666,
-0.007774094,
-0.017486593,
0.0005477358,
0.007309969,
0.048787728,
0.030741457,
-0.015111364,
0.0044569653,
0.031669706,
-0.02412085,
-0.027069408,
0.022032287,
-0.0066990987,
0.014565335,
0.02114499,
-0.019561505,
-0.019261189,
0.041662045,
0.033717316,
-0.007876474,
-0.0069379862,
0.011698681,
0.02412085,
0.014497082,
0.021718321,
0.026332268,
0.013323118,
0.028611941,
-0.03175161,
0.019930074,
0.03639286,
0.029458288,
-0.02038055,
-0.020325946,
-0.0052828346,
-0.007071081,
-0.002370109,
-0.023492916,
-0.028448133,
-0.0060063237,
0.011220905,
0.009323453,
0.009337103,
0.010531543,
-0.026223063,
0.04040618,
0.015357078,
-0.03246145,
0.022673871,
0.0048903762,
0.011944394,
0.0039791893,
-0.040378876,
-0.021950383,
-0.014606287,
0.033143986,
0.030031618,
-0.029840508,
0.027588136,
-0.0029349083,
0.0073167942,
-0.0036037941,
0.006286164,
-0.0027216154,
0.031970024,
0.028857656,
0.013978354,
-0.015930409,
-0.030222729,
0.027164964,
-0.028338928,
-0.016845008,
-0.019861821,
-0.022155143,
0.012858993,
0.030468442,
-0.022278002,
-0.0063851317,
-0.009309802,
-0.017377386,
0.028420832,
0.0021841177,
0.0006671797,
0.011166302,
0.0014068789,
-0.036775082,
-0.009514563,
-0.016804056,
0.0031516135,
0.007248541,
0.000030047615,
-0.013063754,
-0.03969634,
-0.010661225,
-0.017923417,
-0.012463122,
-0.006313465,
0.024216404,
0.026427824,
0.012865818,
0.02614116,
-0.01271566,
-0.0050405343,
-0.010340433,
0.009036787,
0.02058531,
-0.009610118,
0.025363067,
-0.0053237868,
0.015234221,
0.014783747,
0.01408756,
-0.012476772,
0.0031464945,
-0.011371063,
0.01448343,
0.021759273,
0.010804557,
-0.020489754,
0.0020629675,
0.034017634,
-0.0036106196,
0.004760694,
-0.012592804,
0.009241548,
0.011002493,
-0.007828697,
-0.0073782224,
-0.62247354,
-0.041252524,
0.0012388043,
-0.0034809376,
0.011125349,
0.04152554,
0.009084565,
0.00062153506,
-0.012777088,
0.025131004,
-0.019424997,
0.011910267,
0.015097714,
-0.035655722,
-0.034317948,
-0.024953544,
-0.01688596,
-0.014305971,
0.0152615225,
0.009084565,
-0.008845677,
0.017677702,
-0.028857656,
0.013780418,
-0.013200262,
0.03393573,
0.010640749,
-0.010005989,
0.005559262,
0.03915031,
-0.020831022,
0.01336407,
-0.018210081,
0.0076375864,
0.056514047,
-0.0029878048,
0.0121423295,
0.026223063,
0.00066803285,
0.023397362,
-0.01928849,
0.006528464,
0.008224568,
0.004385299,
-0.0051497403,
0.003986015,
0.014592636,
0.013405022,
-0.013828196,
-0.003277883,
0.03191542,
0.0060950536,
-0.029157972,
0.0000150238075,
-0.0049313284,
0.02558148,
0.020912927,
-0.0133981975,
0.02951289,
0.017677702,
-0.015193269,
0.0157666,
0.004695853,
-0.029212574,
-0.01669485,
0.017145324,
-0.0073031434,
0.02637322,
-0.011828362,
-0.020653563,
0.007289493,
0.003342724,
-0.0048357733,
0.00018716439,
0.003073122,
0.03491858,
-0.006033625,
0.013575656,
-0.008845677,
0.0005106228,
0.008599963,
-0.00853171,
-0.035737626,
0.011459793,
0.020325946,
0.024830688,
-0.0082859965,
0.007139335,
0.0105178915,
0.005733309,
0.006351005,
-0.018319286,
-0.003736889,
-0.03450906,
-0.029977016,
0.033116683,
-0.00844298,
0.015384379,
0.0041429983,
-0.02764274,
-0.013254864,
0.010238051,
0.006163307,
-0.003119193,
0.0057264837,
-0.0015101127,
-0.03658397,
-0.011910267,
0.054084215,
-0.01780056,
-0.013882798,
-0.030932566,
0.028038612,
-0.02058531,
0.000013170827,
-0.03287097,
0.03284367,
0.022660222,
0.009958211,
-0.049770582,
0.018059924,
-0.010422337,
-0.015316125,
0.014578986,
0.018674206,
-0.015384379,
0.0051941047,
-0.016926913,
-0.024366563,
-0.011814712,
-0.0017558258,
-0.0046924404,
0.011541697,
-0.01911103,
-0.0090436125,
-0.00013170826,
0.013295816,
0.009753451,
0.001651739,
-0.01307058,
-0.029157972,
-0.013548356,
-0.007405524,
-0.0054056915,
-0.013678038,
0.0001322415,
-0.020339597,
0.0032505814,
0.019124681,
0.011377888,
0.021745622,
0.0025782827,
-0.0073577464,
0.0049210903,
0.023083394,
-0.012183282,
-0.008422504,
-0.02376593,
-0.006965288,
-0.01094789,
0.031478595,
0.0016542985,
-0.008797899,
0.008231394,
-0.011650903,
-0.02320625,
0.026086556,
-0.0023957042,
0.005712833,
-0.03224304,
-0.021390703,
-0.025854493,
-0.03303478,
0.014988508,
-0.0025629257,
0.01780056,
-0.0014316209,
0.015438982,
0.008408853,
0.0026550682,
0.023902439,
-0.04212617,
-0.007200763,
-0.00067101896,
0.025472272,
0.028093213,
0.015821204,
0.013691688,
-0.0007371397,
0.049306456,
0.0045183934,
-0.0037095875,
-0.00806076,
0.01949325,
-0.002165348,
0.011821537,
0.013125182,
0.0035662546,
0.0091732945,
0.038822692,
0.026182111,
-0.011166302,
0.024612276,
-0.018046273,
0.0094121825,
-0.0030628839,
0.0051872795,
-0.0017455878,
0.030195428,
-0.0033768506,
-0.006685448,
0.021964034,
-0.020953879,
-0.013691688,
-0.0026704252,
0.015479934,
0.009664721,
-0.013138833,
-0.014852,
-0.014387876,
-0.00009262237,
-0.004620774,
0.021759273,
-0.0166812,
-0.00872282,
0.019261189,
0.0030355824,
0.035519212,
-0.0073372703,
-0.022523714,
-0.0056206905,
0.032024626,
-0.010203925,
0.006787828,
0.012162806,
-0.0044672033,
0.007439651,
0.00060660456,
0.030823361,
-0.007460127,
-0.017309133,
0.017978018,
-0.009985513,
0.020558007,
0.009221072,
-0.014155813,
0.022523714,
0.020858325,
-0.016435485,
0.011971695,
-0.01178741,
0.0037949046,
-0.009275675,
-0.002030547,
0.00206638,
-0.02817512,
0.0140056545,
0.013254864,
0.03633826,
0.023069743,
0.008606789,
-0.021363402,
-0.003033876,
-0.013992004,
-0.0000091449265,
0.007248541,
0.0121423295,
0.008579487,
-0.0076580625,
-0.027369725,
-0.009446309,
-0.012920422,
0.008948057,
-0.010190275,
0.02005293,
-0.0075625074,
0.026195763,
0.022114191,
-0.0004790555,
0.017568497,
0.011384713,
-0.026987504,
0.04152554,
-0.0048528365,
-0.019998327,
-0.020626262,
-0.04900614,
0.0055353735,
-0.0043887114,
0.043955367,
-0.016585644,
0.0057810866,
0.009029962,
0.008838851,
-0.01984817,
-0.02002563,
0.024967195,
-0.041552838,
0.021663718,
-0.0146335885,
-0.0016210249,
-0.0046275994,
-0.028502736,
-0.027710993,
0.030905265,
0.0020476105,
0.0014631882,
0.0071734614,
-0.010217575,
-0.014019306,
-0.008408853,
0.001661977,
0.0133981975,
-0.013602958,
-0.0022728476,
-0.0010809676,
-0.015848504,
0.0124016935,
0.015125015,
-0.0051668035,
-0.018223733,
-0.0019145156,
0.0063646557,
-0.017554846,
0.013753116,
0.022974188,
-0.0053818026,
0.0016909849,
0.015234221,
-0.009883133,
-0.0057060076,
-0.010497415,
0.027451629,
-0.02543132,
0.0051599783,
-0.0010647574,
-0.012940898,
-0.012162806,
0.03303478,
0.021267846,
-0.012777088,
-0.011678204,
-0.007992506,
-0.022318954,
0.021663718,
-0.0025202672,
0.020626262,
0.012408519,
0.01688596,
0.018278334,
0.0075761583,
0.038877293,
0.0052725966,
-0.012722486,
0.01724088,
0.030577648,
0.0030526458,
0.006566004,
-0.014360574,
-0.035491914,
0.000993091,
0.024803387,
0.0025902272,
0.030004317,
-0.006811717,
-0.008197267,
0.009924085,
-0.017841512,
0.010183449,
-0.014442478,
0.007296318,
0.012340265,
-0.011357412,
-0.012285662,
0.03729381,
-0.0119034415,
-0.013309468,
-0.026850997,
-0.00034020192,
-0.0019998327,
-0.023970691,
0.020871975,
-0.0036993495,
0.008859327,
-0.00006180158,
-0.025090052,
0.0061291805,
-0.015725648,
0.015985012,
-0.0042624422,
-0.01857865,
-0.014592636,
-0.011350587,
-0.019711662,
0.029567493,
-0.018223733,
-0.0269329,
0.0070233033,
0.0011918799,
0.019616107,
0.015875805,
-0.019738965,
-0.0115963,
0.015534537,
0.012094552,
0.010067417,
-0.013213912,
-0.049797885,
0.009432659,
-0.012913596,
-0.013152484,
-0.041061413,
-0.016449137,
-0.0055899764,
0.027246868,
0.007835522,
0.017527545,
-0.007937903,
-0.023984343,
-0.0030082809,
0.010176623,
0.0121423295,
0.01930214,
0.00714616,
0.020598961,
-0.012865818,
-0.022551015,
-0.035382707,
-0.025936399,
-0.027861152,
0.012872644,
0.026359571,
0.0102994805,
-0.011214079,
-0.019684361,
0.008012982,
0.010442813,
-0.007951554,
0.03041384,
0.026018303,
0.0038699836,
0.028994163,
-0.012210583,
0.0024605452,
-0.0053203744,
-0.017950717,
0.021977684,
-0.010613447,
-0.0073031434,
0.0096715465,
-0.0053920406,
-0.02524021,
-0.019834518,
0.023533868,
-0.029430985,
0.032024626,
-0.0036959366,
-0.03475477,
-0.015616442,
0.0076307612,
0.0055899764,
0.009630594,
-0.0051019625,
-0.021964034,
-0.0059346575,
-0.012818041,
-0.0020749117,
-0.006562591,
0.008088061,
-0.03303478,
-0.0057571977,
-0.0032113355,
0.003352962,
0.010135671,
-0.037976347,
-0.029594796,
-0.020080233,
-0.003596969,
-0.023643075,
-0.036638573,
0.000046231202,
0.012060425,
0.026318619,
0.029731302,
0.033963032,
0.014128512,
0.0027164964,
-0.00013714723,
0.0044637905,
-0.0013881092,
-0.010367733,
0.015193269,
-0.009610118,
0.04750456,
0.024803387,
-0.001057932,
0.021390703,
-0.013992004,
0.034672868,
0.010545193,
-0.0071325093,
-0.03764873,
0.010470115,
-0.015370728,
-0.015684696,
0.034099538,
-0.030523045,
-0.01911103,
-0.033608112,
-0.0054534688,
0.009070914,
0.0007908895,
0.007398699,
-0.0076171104,
0.0025663383,
-0.016667549,
0.008954883,
-0.007828697,
0.00644656,
-0.01483835,
0.01464724,
0.012886294,
0.009234723,
0.015998662,
0.006368068,
-0.0034945884,
0.031860817,
-0.037539523,
0.00399284,
0.014961206,
-0.016981516,
-0.014387876,
0.0020049517,
-0.037048098,
-0.04177125,
-0.011562173,
-0.0002646963,
-0.03415414,
0.030086221,
0.011412015,
-0.025485924,
0.002300149,
-0.008948057,
-0.017199926,
0.021431655,
-0.01363026,
0.031314787,
-0.0024759022,
0.019534202,
0.014360574,
-0.006900447,
-0.021786574,
-0.01612152,
-0.015370728,
0.015438982,
0.010599797,
0.044446796,
-0.013022802,
-0.02005293,
0.0033103034,
0.007965204,
-0.024967195,
-0.018565001,
0.023861486,
0.0009649364,
0.017158974,
-0.009432659,
-0.00229503,
-0.014920254,
0.011241381,
-0.010872811,
0.01307058,
0.009787577,
-0.024721483,
-0.029403685,
0.0073782224,
-0.0061291805,
-0.00022353079,
0.020858325,
-0.016967865,
-0.0016875722,
-0.021185942,
0.03044114,
0.009302977,
-0.021076735,
0.0024281247,
0.016776754,
0.0041941884,
0.024230056,
0.009446309,
0.0003026624,
-0.006054101,
-0.008688693,
0.036611274,
0.019356743,
0.013377721,
0.0036788732,
0.008668217,
0.00178654,
-0.022278002,
-0.005808388,
-0.016626596,
-0.028693845,
-0.0026635998,
0.015630092,
0.004535457,
-0.009692023,
-0.002310387,
-0.028120516,
-0.01363026,
-0.0130296275,
-0.031314787,
0.009794403,
-0.048542015,
-0.02469418,
-0.0030765345,
0.015807552,
-0.012592804,
0.008197267,
-0.004136173,
0.0054227547,
0.02373863,
-0.015507236,
0.02560878,
0.014783747,
0.0011441023,
-0.013411848,
0.025595129,
-0.010722653,
-0.033335097,
0.0058152135,
-0.018046273,
-0.03172431,
-0.018114526,
-0.021977684,
0.022428159,
0.026182111,
-0.008388377,
0.013132008,
0.0125313755,
0.00051915454,
0.008572662,
-0.0037744285,
0.0056445794,
-0.029840508,
-0.0027949882,
0.030386537,
-0.021854827,
-0.014046607,
-0.0057162456,
-0.018510398,
0.0016875722,
0.0025731637,
-0.04381886,
-0.020817371,
-0.007419175,
-0.0152615225,
-0.010961541,
0.00816314,
-0.008224568,
-0.022346254,
-0.005688944,
0.011917092,
-0.006897034,
-0.009337103,
0.0040542684,
-0.015493585,
0.0157666,
-0.009289325,
-0.00826552,
-0.003965539,
-0.03672048,
-0.017978018,
0.00011997717,
-0.045375045,
0.030932566,
0.005917594,
0.005764023,
-0.017090721,
0.001077555,
-0.038385868,
0.0131593095,
-0.019097378,
0.00029882314,
0.019834518,
0.020189438,
0.003054352,
-0.003607207,
-0.009425833,
0.009917259,
-0.006596718,
-0.02076277,
0.008797899,
-0.0061906087,
0.026209412,
-0.029021464,
-0.016926913,
-0.0044194255,
0.038249362,
-0.008367901,
-0.004934741,
0.030195428,
-0.007664888,
-0.00445014,
0.009077739,
0.011336936,
0.00965107,
0.011746458,
0.03134209,
-0.028803052,
-0.019438647,
0.0045729964,
-0.009050438,
-0.004235141,
0.015425331,
0.01987547,
0.010572495,
0.004231728,
-0.017554846,
-0.038140155,
0.0050610104,
-0.0012823159,
0.013077404,
0.028639244,
0.0056104525,
0.0019469361,
0.022701174,
-0.016353581,
-0.0024861402,
0.007869649,
-0.018633254,
-0.014183114,
0.009521388,
0.02338371,
0.009698847,
-0.01801897,
0.025950048,
-0.02522656,
-0.016926913,
-0.006378306,
0.011650903,
-0.0013343594,
0.019083729,
-0.006722987,
0.023711327,
-0.023274504,
0.02094023,
-0.011357412,
-0.022878634,
0.0020697927,
0.010463289,
0.011377888,
-0.013896449,
-0.0018855078,
-0.0045593455,
-0.0036515717,
-0.010633923,
-0.024393864,
-0.011712331,
0.02043515,
0.18499477,
0.015302475,
0.009500912,
0.0012806096,
-0.007862824,
0.0004261589,
-0.00206638,
-0.010736303,
0.023056092,
-0.0021346337,
0.028830353,
0.002190943,
0.008477107,
-0.0055558495,
0.016449137,
-0.0052248193,
-0.017090721,
-0.043955367,
-0.01726818,
-0.0012089433,
0.015329776,
-0.0024946718,
0.003876809,
0.02300149,
0.03227034,
0.019370394,
-0.022018638,
0.00063049333,
0.014442478,
-0.0085453605,
-0.030550346,
-0.009719323,
0.008483932,
0.0037198255,
-0.0014205297,
0.0014333272,
-0.018496746,
-0.020981181,
0.02114499,
-0.006743463,
-0.01594406,
0.017322784,
-0.018592302,
0.0011748164,
0.0035048265,
0.010026465,
0.0009726149,
-0.04029697,
-0.0027352662,
-0.008961708,
-0.0426722,
-0.010920589,
0.014142162,
-0.007214414,
0.008838851,
-0.0029229638,
0.0012516018,
0.00028965154,
-0.0061360057,
0.0055217226,
0.005917594,
-0.0005204343,
-0.024325611,
0.01243582,
-0.018947221,
0.009009485,
-0.00681513,
-0.0024110612,
0.052009303,
-0.025595129,
0.011336936,
-0.016817706,
-0.019151982,
-0.011637252,
0.007555682,
-0.020216739,
0.010763605,
0.0213361,
0.028093213,
0.017773258,
0.022919586,
0.00014023998,
-0.0029161384,
0.010053767,
-0.01837389,
-0.022141494,
0.01502946,
0.004665139,
-0.028502736,
-0.0024486007,
0.003822206,
-0.017036118,
-0.026264016,
0.0048937886,
0.0371027,
-0.00042189306,
0.01307058,
-0.00704378,
-0.0025287988,
-0.03210653,
-0.026468776,
0.072840326,
-0.00050166453,
0.007569333,
-0.017172625,
-0.0009171588,
-0.008449805,
0.021622766,
0.015452633,
-0.0050371215,
0.0053954534,
-0.0030424078,
0.015698345,
-0.01410121,
0.006432909,
0.016967865,
-0.003965539,
-0.01837389,
0.04215347,
-0.010763605,
0.006316878,
-0.0389319,
0.012176456,
0.009978687,
0.008231394,
0.017309133,
-0.045702662,
-0.011336936,
0.004040618,
-0.038249362,
0.013964702,
0.013896449,
0.009132342,
0.00945996,
0.019520553,
0.0020680865,
0.023151647,
-0.010210751,
0.0054671196,
0.02301514,
-0.0027523297,
0.0047436305,
0.008791074,
0.017841512,
-0.000008591698,
0.01326169,
0.033143986,
0.0127702635,
-0.020394199,
-0.028611941,
-0.0038290313,
-0.007309969,
-0.009323453,
-0.017964369,
0.0064943377,
-0.020489754,
-0.017118022,
-0.00826552,
0.006972113,
-0.006879971,
-0.03688429,
0.004177125,
0.016217073,
-0.001382137,
-0.011193603,
-0.008832026,
-0.17287292,
0.025540527,
0.01298185,
-0.015165967,
0.05288295,
0.0022933236,
-0.006153069,
0.007330445,
-0.01150757,
0.009862657,
0.016653897,
-0.00844298,
-0.014415177,
-0.018605953,
0.003617445,
0.0011517808,
-0.0047333925,
0.037403017,
0.010463289,
0.012695184,
0.024216404,
-0.018537698,
0.027915755,
-0.014333272,
0.0038290313,
0.0055012465,
-0.003339311,
-0.007753618,
0.0045081554,
-0.030195428,
-0.022332603,
-0.00644656,
0.0075079044,
-0.00001606361,
-0.0050337086,
0.010702177,
-0.0055353735,
0.0037164127,
0.003532128,
0.026318619,
0.028338928,
0.024625927,
-0.013725814,
-0.014155813,
-0.017227229,
0.018824365,
0.0033546684,
-0.008552186,
-0.008149489,
-0.011302809,
0.01298185,
-0.019534202,
0.012763438,
0.01594406,
0.041416332,
0.014947556,
-0.00045815282,
-0.025131004,
-0.0009811466,
-0.0033444304,
0.0076717134,
-0.0025970524,
0.032570656,
0.024243707,
-0.009869482,
-0.04138903,
-0.018278334,
0.0087842485,
-0.007296318,
0.009958211,
-0.019261189,
0.01946595,
0.021199593,
-0.0068185423,
0.023110695,
0.022100542,
-0.009548689,
-0.013241214,
-0.00028026666,
0.010456463,
-0.029813206,
0.021936731,
-0.0408157,
-0.026031952,
-0.014360574,
0.0060097366,
0.022701174,
0.001252455,
0.013200262,
0.0005737575,
0.009883133,
-0.023424663,
-0.0043443465,
-0.023356408,
0.017404689,
0.012858993,
0.0040542684,
-0.020517055,
-0.008866153,
0.014073908,
0.0089139305,
0.0006919217,
0.0053067235,
-0.0022864982,
0.030386537,
0.0031823278,
-0.024475768,
0.0015860449,
0.031314787,
-0.0058118007,
-0.010483765,
0.021404354,
0.013691688,
0.01233344,
0.0008288556,
0.0136370845,
0.0062691006,
-0.014619938,
-0.01949325,
-0.01502946,
0.080976166,
0.007385048,
-0.010074243,
0.015111364,
0.000044124936,
-0.051490575,
-0.12405789,
-0.0026721314,
0.013336768,
0.011493919,
-0.01280439,
0.018414842,
-0.0003527862,
0.026468776,
-0.0013633672,
0.03287097,
-0.007480603,
-0.020121185,
0.0060063237,
0.00161164,
0.017049769,
-0.010367733,
0.020462453,
-0.031423993,
-0.034836676,
0.04327283,
-0.008006156,
0.010893287,
-0.003917761,
-0.007009653,
-0.0013096174,
-0.014824699,
-0.01801897,
0.03412684,
0.009610118,
0.023588471,
0.020858325,
-0.014060258,
0.023028791,
0.0029024878,
-0.034727473,
0.0013249746,
0.0046514883,
-0.04474711,
0.008449805,
-0.011958044,
0.010572495,
0.019397695,
0.009221072,
-0.020858325,
0.008975359,
-0.0059107686,
-0.0011219198,
0.0036106196,
0.0074874284,
-0.0047743446,
-0.023397362,
-0.019070078,
-0.032898273,
0.0010997374,
0.017650401,
-0.039669037,
0.019274838,
0.009685197,
-0.011336936,
0.0039348244,
-0.0131593095,
-0.009705673,
-0.0023274506,
-0.0022728476,
0.008975359,
-0.009268849,
-0.022032287,
-0.049606774,
0.01819643,
-0.009139167,
0.001791659,
-0.0021499908,
-0.012162806,
0.0041839504,
-0.0048187096,
0.007965204,
-0.025526876,
0.015752949,
-0.0030748283,
0.011295984,
-0.026182111,
-0.008599963,
0.010490591,
-0.0035457786,
0.02245546,
-0.009200596,
0.029758604,
0.0052555334,
-0.0015945765,
-0.009930911,
-0.014906603,
0.037785236,
-0.012408519,
0.002909313,
-0.03991475,
0.0023257441,
0.015739297,
0.012428995,
-0.0050678356,
0.025663383,
-0.023137998,
-0.006784416,
-0.06050006,
0.010326781,
-0.008169965,
0.0019895947,
0.0023069743,
-0.023970691,
-0.00079728826,
-0.013077404,
0.0038256187,
0.017036118,
-0.040679194,
0.001632116,
-0.0033717316,
0.0016824532,
-0.02783385,
-0.015043111,
0.021158641,
0.000008551706,
0.015930409,
0.015343427,
-0.006798066,
-0.019738965,
0.010347257,
0.0020441976,
0.004460378,
-0.027574485,
-0.029021464,
-0.012592804,
0.008101712,
0.003462168,
0.021240545,
-0.036147147,
-0.0136370845,
0.00023910117,
-0.022551015,
0.007835522,
-0.017759606,
0.014947556,
0.0037607776,
0.02466688,
0.0027301472,
-0.020121185,
0.011848839,
-0.022482762,
-0.0002072139,
-0.019206585,
-0.025185607,
0.0051531526,
-0.012169631,
-0.03658397,
0.029977016,
-0.003682286,
-0.019957375,
-0.021445306,
-0.03134209,
0.008872978,
0.003303478,
-0.026386872,
-0.025513224,
-0.010183449,
0.0065148138,
0.023888787,
0.031205582,
0.009965037,
0.0037641905,
-0.007016478,
-0.029731302,
0.01335042,
0.0013241214,
-0.025540527,
-0.026659887,
-0.010463289,
0.02820242,
-0.00095640466,
0.017827861,
-0.0054773577,
-0.012824866,
0.017145324,
-0.015903108,
0.009992339,
0.02376593,
-0.0003909656,
-0.021254195,
0.01984817,
0.0013881092,
-0.0007908895,
-0.0027352662,
0.024257358,
0.0049722805,
-0.0025083227,
-0.0104291625,
0.010797732,
-0.003453636,
0.005852753,
0.0018018971,
-0.0047675194,
-0.009132342,
0.0008847383,
-0.00024294044,
0.015711997,
-0.010122021,
0.014169464,
-0.009500912,
0.00052725966,
0.00033444303,
0.023301806,
-0.022605618,
-0.039559834,
-0.011391539,
-0.00052768626,
0.029622097,
0.02261927,
0.0058493405,
0.013678038,
-0.009419007,
0.03934142,
0.011330111,
-0.011541697,
-0.0042999815,
0.025758939,
0.013814544,
0.022237048,
0.0231926,
-0.014920254,
-0.0044569653,
-0.0009802935,
0.017227229,
-0.019506902,
0.030495744,
-0.017008817,
0.032488752,
-0.0058356896,
-0.020011978,
0.010319957,
-0.034044936,
-0.005818626,
0.013234388,
0.016749453,
-0.008941232,
0.10139766,
0.011132175,
-0.01891992,
0.0016090805,
-0.023492916,
0.00093934126,
-0.003627683,
0.0049620424,
0.002061261,
-0.04775027,
0.008142664,
0.0026448302,
0.037430316,
-0.022004986,
-0.013616608,
0.0002161722,
-0.0039484752,
0.0070233033,
0.0037846665,
-0.020749118,
0.019206585,
-0.012940898,
-0.01224471,
0.013848672,
-0.022114191,
-0.009494087,
0.03505509,
0.0053101364,
-0.000098008015,
-0.02149991,
-0.012476772,
-0.022209747,
-0.018401193,
-0.014183114,
0.0060063237,
-0.020735467,
0.009425833,
-0.030959869,
0.0011893203,
0.017418338,
-0.0075079044,
-0.0007141041,
-0.01800532,
-0.021568162,
0.01836024,
0.001516938,
-0.008149489,
-0.012811216,
-0.0019452298
] |
Nucleosomes containing the histone variant H3.3 tend to be clustered in vivo in the neighborhood of transcriptionally active genes and over regulatory elements. It has not been clear, however, whether H3.3-containing nucleosomes possess unique properties that would affect transcription. We report here that H3.3 nucleosomes isolated from vertebrates, regardless of whether they are partnered with H2A or H2A.Z, are unusually sensitive to salt-dependent disruption, losing H2A/H2B or H2A.Z/H2B dimers. Immunoprecipitation studies of nucleosome core particles (NCPs) | [
-0.02504726,
0.0048318733,
0.0032506236,
-0.015988745,
-0.0133416895,
0.039825544,
-0.0126300445,
-0.0026852977,
-0.014153099,
-0.001494788,
0.008167296,
0.002071753,
0.009105071,
-0.004755388,
0.002504061,
-0.0036313871,
0.022852466,
-0.018356463,
0.006970135,
0.001039202,
-0.017584959,
0.0010541665,
-0.016441006,
-0.023650574,
-0.011379677,
0.009071817,
0.011678967,
-0.02637744,
-0.007475603,
-0.014046685,
0.012177784,
0.009105071,
-0.009191534,
0.0038475413,
-0.021043424,
-0.0058760634,
0.013621028,
-0.028226387,
0.007582017,
-0.007907911,
0.012503677,
0.014738377,
-0.013235276,
0.0076219225,
-0.00038720664,
0.0051843706,
0.021562193,
-0.0062584896,
-0.01751845,
0.019580226,
0.014512247,
0.030168448,
-0.0022546526,
-0.0039373282,
-0.015869029,
-0.008233804,
0.017651469,
-0.00021178935,
-0.007169662,
-0.017265717,
0.0057230927,
-0.014445738,
-0.011831937,
0.01774458,
-0.0017525101,
0.005157767,
0.007661828,
-0.004525932,
0.009816717,
0.0017175929,
0.036579907,
0.01751845,
-0.024116136,
-0.005516915,
0.0260981,
-0.0074623013,
-0.02593848,
0.00024275757,
0.0048485002,
0.0032140438,
0.016800154,
-0.0028299547,
-0.010036197,
0.007841402,
0.017757883,
0.025020657,
-0.0019603504,
-0.012284198,
0.0113264695,
-0.016866663,
0.028864872,
0.028332802,
0.024688112,
0.014618661,
-0.01915457,
0.0022596407,
0.0058162054,
0.008074183,
-0.005131163,
-0.027986955,
-0.031658247,
0.018183539,
-0.03362691,
-0.020551257,
-0.015469976,
-0.015469976,
0.02601829,
-0.007655177,
-0.001543007,
-0.0028615464,
-0.0057131164,
0.009743557,
-0.00068130076,
-0.041315343,
0.039080642,
-0.01609516,
0.018502783,
0.0045525357,
0.0071497094,
-0.0067040995,
0.008912195,
0.046237003,
0.012104624,
-0.028412612,
0.008579651,
0.019686641,
-0.020830594,
-0.020298524,
-0.0030311442,
-0.010262326,
0.019713245,
0.0067273774,
0.005733069,
0.010707936,
-0.041634586,
0.0008209695,
0.006647567,
-0.019912772,
-0.016800154,
-0.03703217,
0.004057044,
0.03362691,
-0.028119972,
0.0010150925,
0.036633115,
0.013913667,
0.012636695,
0.016587324,
-0.017771184,
0.008918847,
0.006438064,
-0.0032140438,
0.02049805,
0.027401676,
0.001570442,
0.016507514,
-0.0050546783,
0.0076950826,
-0.018795421,
-0.029902412,
-0.014139797,
0.005949223,
0.009570634,
0.020298524,
0.029210718,
0.031950887,
0.005829507,
-0.026111403,
0.00032547803,
-0.010574919,
-0.013015796,
0.002173179,
-0.014352625,
0.00049424445,
-0.02333133,
0.020537956,
0.007036644,
0.030647311,
-0.028785061,
-0.021216346,
-0.009351155,
0.0074423486,
0.021083329,
0.006561105,
-0.012038115,
-0.006650892,
0.01931419,
-0.030141843,
0.00047678585,
-0.012377311,
-0.00090867816,
-0.015190638,
0.0027784102,
-0.010162563,
-0.6478501,
-0.0178776,
0.0009527403,
-0.032243527,
0.0025738953,
0.02571235,
0.014365927,
0.018369764,
-0.022346998,
0.018343162,
-0.003235659,
0.017372131,
0.011705571,
-0.024714716,
-0.046449833,
-0.03317465,
-0.010242374,
-0.014379229,
0.04807265,
-0.00087625504,
-0.021043424,
-0.009058516,
-0.011964955,
0.014924603,
0.024023023,
0.010116007,
0.011672316,
-0.012264245,
-0.004033766,
0.030806933,
-0.027148942,
0.006777259,
-0.0064181113,
0.008446633,
0.04434815,
0.008040929,
0.007342585,
0.027228752,
0.029317133,
0.02698932,
-0.0000014646253,
-0.022905674,
0.017132698,
0.017252415,
-0.011047132,
0.024728017,
-0.015589692,
0.017239112,
0.015150732,
-0.0017175929,
0.009091769,
-0.0016460959,
-0.0112666115,
0.011678967,
0.010036197,
0.007768242,
0.03048769,
-0.024355568,
0.008832385,
0.000083915555,
0.00063432887,
-0.014924603,
-0.013228625,
-0.032615975,
-0.02355746,
-0.0017940782,
-0.005324039,
-0.00030947433,
0.00797442,
0.0026104753,
-0.02974279,
0.035888214,
0.011020528,
0.0031375585,
-0.009065166,
0.028412612,
-0.003386967,
0.00946422,
-0.011499393,
0.021269554,
-0.011020528,
-0.0070033898,
-0.021562193,
-0.012197737,
0.020670973,
-0.0025256763,
-0.022972181,
0.039479695,
0.0014814863,
-0.014711774,
-0.0061254716,
0.0076950826,
0.007854704,
-0.021628702,
-0.02446198,
0.007941165,
0.018462878,
0.008187248,
0.004346358,
-0.0019786404,
-0.021814927,
-0.0069900877,
0.0073093306,
-0.008486538,
0.024355568,
-0.0055934004,
-0.0016976403,
0.018050522,
0.043257404,
-0.02192134,
0.0013941933,
-0.0019254333,
-0.027907144,
-0.029769395,
-0.003283878,
-0.024621604,
0.03689915,
0.015310354,
-0.014113193,
-0.01617497,
0.025619237,
0.018835327,
-0.0031857775,
-0.009277995,
0.0113996295,
-0.00065386586,
0.021109931,
0.006058963,
-0.013454755,
-0.024009721,
0.02362397,
0.0075221593,
0.012809618,
-0.04410872,
0.025033958,
0.020325126,
0.023823496,
0.004466074,
0.028412612,
-0.018941741,
-0.020005884,
0.012004861,
0.0046489737,
-0.004086973,
-0.009357805,
-0.042751934,
-0.021282855,
0.0123041505,
0.0033204579,
-0.0008687728,
0.0039073993,
0.009437616,
0.000019757827,
0.00016606446,
-0.0012778026,
0.001363433,
-0.009204835,
-0.03048769,
-0.008566349,
-0.017904202,
-0.0022879068,
0.0064447145,
-0.008473237,
0.009816717,
-0.017784486,
-0.020777388,
-0.0060556373,
-0.0015463325,
0.0074356976,
-0.025180278,
0.014858093,
-0.0019919423,
-0.02399642,
0.0070499456,
-0.004116902,
0.022001151,
-0.017545054,
0.00946422,
-0.018289953,
-0.0011140244,
-0.019101363,
-0.01408659,
-0.009377758,
-0.019633435,
0.043204196,
0.008579651,
0.032536164,
0.008765876,
0.023291424,
0.024728017,
0.0146452645,
0.003518322,
-0.003375328,
0.0036513398,
0.0056865127,
-0.030647311,
0.032376543,
0.009437616,
0.017026285,
0.017039586,
0.019407304,
0.005254205,
-0.0023361258,
-0.031285796,
0.02451519,
-0.032376543,
0.0069900877,
-0.014432436,
-0.013767347,
-0.011240008,
-0.008340219,
-0.0039539556,
-0.012463772,
0.0028133274,
-0.01528375,
0.008725971,
-0.012836223,
-0.0056599095,
0.009796765,
-0.008553048,
0.024767922,
-0.0071364073,
0.024914242,
0.022706145,
-0.005822856,
-0.013527915,
0.013288483,
0.019407304,
-0.0004406216,
0.0071962653,
-0.018941741,
0.0071231057,
-0.018755516,
0.0041268785,
0.009038563,
0.01147944,
0.012656648,
-0.0092513915,
0.023490952,
0.0030943276,
-0.0024841083,
0.0026636824,
-0.010821002,
-0.0092513915,
0.029609773,
0.0024026348,
0.032589372,
0.0013858797,
-0.013421501,
-0.00048094266,
-0.006694123,
-0.02103012,
-0.00046389975,
0.004130204,
0.016879965,
-0.012989192,
0.007781544,
0.011765429,
0.044853617,
0.017465243,
0.018595895,
-0.01266995,
-0.0039838846,
-0.016520817,
0.021588797,
-0.017146,
0.00087209826,
0.0067639574,
-0.014631963,
0.005264181,
-0.027242055,
0.0033370852,
0.005413826,
-0.021256251,
0.004210015,
0.0034484877,
0.009324551,
0.004372962,
0.009264693,
0.018210143,
-0.022506619,
-0.02854563,
0.017558355,
0.03184447,
-0.0054670335,
0.0023045342,
-0.033254463,
0.0052808085,
0.0022496644,
0.018888535,
0.0018356462,
0.0006559442,
-0.0028615464,
0.0017225811,
-0.010561617,
0.0011614121,
0.014525549,
-0.017784486,
0.013062352,
-0.0039240266,
-0.005297436,
-0.0073957923,
-0.014339324,
0.0011938352,
0.019101363,
0.012869476,
0.0068836734,
-0.0057763,
-0.013581122,
-0.016933171,
0.008014325,
-0.0064447145,
0.018476179,
0.013807252,
-0.010348788,
0.0017791137,
0.012989192,
0.01886193,
0.019487115,
0.0034451622,
-0.016307987,
-0.01967334,
-0.0023361258,
0.00080060115,
0.007941165,
0.031312402,
-0.014658567,
0.006178679,
0.008932148,
0.011678967,
-0.013860459,
-0.01699968,
0.009663747,
-0.0164011,
-0.010967322,
-0.0043796124,
0.008666113,
0.011426233,
-0.0024325638,
0.022346998,
0.0026204516,
-0.034345206,
-0.009430965,
0.0009768498,
0.010268978,
-0.000697928,
0.005224276,
0.051025644,
0.024422076,
-0.011891795,
-0.0013110571,
0.041554775,
0.003332097,
-0.023238217,
0.0024641557,
0.0041102516,
0.010282279,
0.012290849,
-0.0011306517,
-0.04791303,
0.0058760634,
0.022825863,
0.022107566,
-0.0096371425,
-0.00042087678,
0.0075687156,
0.025313295,
0.0050214236,
-0.006388182,
0.0009394385,
0.014977809,
0.022200678,
-0.018010616,
0.012829571,
0.020963613,
-0.025180278,
-0.010388694,
-0.015895633,
-0.008958752,
-0.019260984,
-0.0040370915,
-0.024023023,
0.010202468,
-0.04041082,
-0.013108909,
-0.017970711,
-0.00013779817,
-0.0016577349,
-0.022785956,
-0.03407917,
0.0010101043,
-0.01118015,
-0.036021233,
-0.0059392466,
0.012144529,
-0.025871972,
-0.03785688,
-0.00212496,
0.03168485,
0.00805423,
0.009284645,
-0.00901861,
-0.0056299805,
0.012935986,
-0.0048119207,
-0.017531753,
0.005613353,
-0.0127630625,
0.003481742,
-0.0067639574,
-0.004372962,
-0.01632129,
-0.0031309074,
-0.010541664,
0.005397199,
-0.015270448,
0.012324103,
0.009277995,
-0.0061221463,
0.023823496,
0.022253886,
0.03934668,
0.008453284,
0.0052741575,
0.0006014901,
-0.020404937,
-0.018595895,
-0.022293791,
-0.0018339836,
-0.016720343,
-0.0031176058,
0.017172603,
-0.008672764,
-0.0025788834,
0.016081858,
-0.030248258,
-0.0018938415,
0.015270448,
0.0033121444,
0.023384538,
-0.005603377,
0.0076950826,
-0.021881435,
-0.015935538,
0.008812432,
-0.015150732,
0.022320395,
-0.0041102516,
-0.018276652,
0.013647631,
0.006717401,
0.0054969625,
-0.007422396,
-0.017930806,
-0.007036644,
0.038442157,
-0.0047055064,
-0.012004861,
-0.0040038372,
-0.020404937,
0.0053473176,
-0.0070166914,
0.0009810067,
-0.021375967,
0.0064580166,
-0.0020069068,
-0.01886193,
-0.026776493,
-0.032908615,
-0.030700518,
-0.011712221,
0.03227013,
-0.009144977,
-0.0058095544,
-0.0028499074,
-0.013241926,
-0.006115495,
-0.032243527,
-0.020604465,
-0.028944682,
0.019420605,
0.006052312,
0.032376543,
0.02116314,
0.033227857,
0.007894609,
-0.006527851,
0.027907144,
0.016214876,
0.0059093176,
-0.0017824392,
0.027321866,
-0.013095607,
0.01065473,
0.0009535717,
-0.010042847,
-0.0035615528,
-0.0009211486,
0.020897103,
0.023397839,
0.005999105,
-0.041687794,
0.015908934,
-0.03184447,
-0.028944682,
-0.009284645,
-0.01588233,
0.0053340155,
-0.043390423,
-0.010867558,
-0.004875104,
-0.009683699,
0.024994053,
-0.02690951,
0.044906825,
0.00009368405,
0.01610846,
-0.009856623,
-0.00077566033,
-0.005320714,
0.023584064,
-0.011565901,
0.014286117,
0.023916608,
-0.008001023,
0.0117255235,
0.0049582403,
-0.0028848245,
0.006088892,
0.012330755,
-0.025100468,
-0.01050841,
-0.016494213,
-0.003295517,
-0.023078596,
-0.01102718,
-0.0022845815,
-0.046529643,
0.0072095674,
-0.011279914,
0.0016577349,
0.0030494342,
0.0058461344,
-0.0054005245,
0.022998786,
-0.0007644369,
0.035302937,
-0.01617497,
0.017797789,
0.0081406925,
-0.006501247,
-0.03546256,
-0.03317465,
-0.018875232,
0.016135065,
0.034637846,
0.012084671,
-0.019992582,
0.0010350451,
0.0034451622,
0.019247683,
-0.011991559,
-0.038255934,
0.0006376543,
-0.01609516,
-0.008074183,
-0.005792927,
-0.0025439663,
-0.015709408,
0.011758777,
-0.010388694,
0.03011524,
0.007821449,
0.004509305,
-0.015097526,
0.00849319,
0.011093688,
0.025911877,
0.0061454247,
0.02430236,
-0.0010275629,
-0.012357358,
0.019287588,
0.01773128,
-0.010182516,
0.026962718,
-0.014246211,
-0.009776812,
0.013953572,
0.027029226,
-0.0018040545,
-0.0047986186,
-0.008765876,
0.037670653,
-0.026071498,
-0.011439535,
0.03123259,
0.010302233,
-0.006910277,
0.009577285,
-0.008519793,
-0.007482254,
-0.016746948,
0.005137814,
0.01923438,
0.010754493,
0.0047454117,
-0.031950887,
-0.0010799386,
0.009849971,
-0.038362347,
-0.008366822,
-0.0055036135,
-0.035595577,
-0.021735117,
0.014445738,
0.016427703,
0.02130946,
-0.0033653516,
0.0012586814,
-0.00790126,
0.013241926,
-0.01781109,
0.00034148176,
0.006587709,
-0.00015484108,
-0.038149517,
0.005171069,
-0.01095402,
-0.037883483,
-0.001591226,
-0.027827334,
-0.026736587,
-0.0044860267,
-0.009470871,
0.034531433,
0.03562218,
-0.011339772,
0.005171069,
0.0057230927,
0.03221692,
0.004279849,
-0.012909382,
0.02623112,
-0.017478544,
-0.001975315,
0.010282279,
-0.016427703,
-0.015124129,
-0.012929334,
-0.037537634,
0.023464348,
-0.0036014582,
-0.008892243,
-0.0061387736,
-0.00046930357,
-0.00760197,
-0.0016652171,
0.017385432,
-0.023983117,
-0.0017508474,
0.0011373026,
0.0036579908,
-0.0015305366,
-0.021336062,
0.0117255235,
0.026044894,
-0.001552152,
-0.014565454,
-0.005171069,
0.0007606958,
-0.045571912,
-0.057304088,
0.01468517,
0.0013035749,
0.026936114,
0.0058428086,
-0.024435379,
0.0042898254,
-0.005639957,
-0.04203364,
0.0014457377,
-0.004569163,
-0.008160645,
0.009171581,
0.018915137,
-0.0029679607,
0.0030810258,
-0.002647055,
0.017571658,
0.010401996,
-0.024701415,
0.0033819787,
-0.03681934,
0.023211613,
0.029955618,
-0.014472341,
0.018063823,
0.033653516,
0.0015155721,
-0.016720343,
0.026271025,
0.0031259193,
0.022227282,
-0.013221974,
0.021256251,
-0.013441454,
0.025632538,
0.025220184,
-0.018462878,
-0.018236747,
-0.009497474,
-0.0109407175,
-0.019832961,
0.010781096,
-0.019274285,
0.0015139093,
0.00607559,
-0.016334591,
-0.042805143,
0.0022263862,
-0.028864872,
0.00879913,
0.029476754,
0.003308819,
0.011811985,
0.004063695,
-0.0115526,
-0.0072029163,
-0.004748737,
-0.03160504,
-0.014631963,
-0.004017139,
-0.017704675,
-0.014498945,
-0.0045492104,
-0.0043031275,
-0.010189167,
0.008280361,
0.008479888,
-0.015789218,
-0.032030698,
0.0004963228,
-0.004978193,
-0.014059986,
0.011126943,
-0.02370378,
-0.017558355,
0.0012453796,
0.014206306,
-0.014365927,
-0.0010383705,
0.006238537,
0.0023061968,
-0.022613034,
-0.026896209,
-0.0014490632,
-0.015895633,
-0.0013991814,
0.0025905226,
0.18356463,
-0.010887511,
-0.010468504,
0.013754046,
0.006657543,
-0.0030843513,
0.009258042,
-0.010867558,
-0.0026320906,
0.0032024046,
0.029077701,
0.009630492,
-0.029636376,
0.0042665475,
0.032882012,
-0.029929016,
-0.036712926,
-0.004090299,
-0.0380165,
0.0076884315,
-0.011625759,
-0.021455778,
0.0003427288,
0.0004406216,
0.03227013,
0.0017491847,
-0.019127967,
0.0006068939,
-0.029263927,
0.03184447,
-0.024555095,
-0.0023361258,
-0.0011057109,
-0.009530729,
-0.0024059603,
0.0015230543,
-0.02713564,
0.0045458847,
-0.018888535,
0.02035173,
-0.013860459,
-0.0012171133,
-0.0045724884,
-0.0021232974,
0.0033237834,
0.012364008,
0.020564558,
0.01729232,
-0.026350835,
-0.0057596727,
-0.028013559,
0.010089404,
0.00039177912,
0.03370672,
0.0050314,
-0.0006351602,
0.019433906,
-0.0005266675,
-0.0072627743,
0.018609196,
-0.005380572,
0.019034853,
-0.035010297,
0.015110827,
0.011951653,
0.029609773,
-0.0104219485,
0.0121711325,
0.027082434,
-0.013754046,
0.028785061,
-0.0038142868,
-0.020537956,
-0.0011830275,
0.007967769,
-0.015908934,
0.049908295,
0.019114664,
0.026284326,
0.012324103,
0.009437616,
0.0064812945,
-0.015908934,
0.004555861,
0.01356782,
-0.025220184,
0.034158982,
-0.0015696106,
-0.0074556503,
-0.016002046,
0.008706018,
-0.0104219485,
-0.01767807,
-0.013421501,
0.01596214,
-0.003357038,
-0.010920765,
0.0059458977,
-0.020511352,
0.0020218713,
-0.021602098,
0.06954173,
0.0005516084,
0.021229649,
-0.0033287716,
0.0003211134,
0.0061221463,
-0.0070765493,
0.010415297,
0.0028948009,
0.030062033,
-0.015336958,
0.006231886,
-0.0044161924,
0.01588233,
0.011512695,
-0.008439982,
-0.051903564,
0.060709346,
-0.015230543,
0.0024042975,
-0.013527915,
0.00064305816,
0.037750464,
0.002989576,
-0.01192505,
-0.014219607,
0.0070698983,
-0.024289059,
-0.03421219,
0.014073288,
-0.004100275,
0.012616742,
0.0060024303,
-0.010049499,
-0.022147471,
-0.005427128,
-0.00064472086,
-0.0079478165,
0.02796035,
-0.012204387,
-0.018010616,
0.023544159,
-0.0007328452,
-0.0031092921,
-0.00063640723,
0.017997315,
0.023650574,
-0.01445904,
-0.01222434,
0.0029147535,
-0.013135512,
-0.0050879326,
0.014658567,
0.0049083587,
-0.02817318,
-0.020631067,
-0.032988425,
-0.02452849,
0.02377029,
-0.03115278,
0.020032488,
0.008406728,
-0.0046689264,
0.0014673531,
0.0062551643,
-0.1677089,
0.029716186,
0.020631067,
-0.028785061,
0.021575494,
0.014658567,
0.024275757,
-0.02049805,
-0.004027115,
-0.010787747,
0.0009835007,
0.009364456,
-0.028785061,
-0.048498306,
0.0015338621,
-0.008360172,
0.0005952549,
0.04182081,
0.025446314,
-0.011506043,
0.0017175929,
-0.024156041,
0.033440687,
-0.010801049,
0.010621475,
0.034185585,
-0.014020081,
-0.020032488,
0.0056599095,
-0.008706018,
0.014113193,
0.0073891412,
0.011439535,
-0.0026204516,
0.028332802,
0.023357933,
-0.004203364,
0.009371107,
-0.0027401675,
0.013248578,
0.00533069,
0.0066675195,
0.0048052697,
-0.013228625,
-0.02035173,
0.023091897,
-0.0059093176,
0.007448999,
0.028971286,
0.0018988297,
-0.0024292383,
-0.0049881693,
0.018063823,
0.021482382,
0.01594884,
0.0063383,
0.009909829,
0.029237323,
-0.013547868,
-0.01557639,
-0.0051843706,
-0.019872867,
0.036845945,
0.005510264,
-0.012616742,
-0.030434484,
0.005902667,
0.0023627295,
-0.03219032,
-0.002635416,
-0.007482254,
-0.005799578,
-0.01252363,
-0.023690479,
0.017438639,
0.018090427,
-0.0076950826,
0.009949734,
0.020764086,
-0.0026553688,
-0.02451519,
0.016347893,
-0.030354673,
-0.030514294,
-0.0136077255,
0.01855599,
-0.014299419,
0.007708384,
-0.0058394833,
0.008513142,
0.005679862,
-0.0054005245,
0.014246211,
-0.0040503936,
0.022772655,
0.023198312,
-0.02221398,
0.00054745155,
-0.014791585,
-0.009065166,
0.018981647,
-0.019926073,
-0.031445418,
0.01654742,
0.031551834,
0.008712669,
-0.017611563,
0.009138326,
0.05687843,
-0.02734847,
0.003884121,
-0.0034152332,
0.016480912,
0.027375072,
-0.0134148495,
0.031551834,
0.0009826693,
-0.0043629855,
0.0023843448,
-0.01931419,
0.058527853,
-0.0024042975,
-0.025020657,
0.006497922,
-0.003890772,
-0.02653706,
-0.13237935,
-0.0007727505,
-0.016866663,
0.02064437,
-0.026138006,
0.014166401,
0.005866087,
0.024794526,
-0.020551257,
0.043071177,
-0.012816269,
0.022559827,
0.010568268,
-0.005134489,
-0.0029164162,
-0.00086212193,
0.0071364073,
-0.0048351986,
-0.012783015,
0.038229328,
-0.0062950696,
0.004971542,
-0.0033337597,
-0.024994053,
0.030913347,
-0.004412867,
-0.014206306,
0.009065166,
0.016148366,
0.008759225,
-0.008898894,
-0.024954148,
-0.0029613099,
-0.004186737,
-0.024129437,
-0.000024278355,
-0.0052209506,
-0.015217242,
0.045066446,
-0.004808595,
-0.004466074,
0.010967322,
-0.0023361258,
0.003373665,
0.010781096,
-0.02430236,
-0.021708513,
0.0013343353,
0.025113769,
0.013468057,
-0.017691374,
-0.009078468,
-0.016294686,
-0.022320395,
0.018090427,
-0.0054038498,
0.031445418,
0.046609454,
-0.030753726,
-0.013148814,
-0.009005308,
0.009377758,
-0.014498945,
0.007342585,
0.022187376,
-0.00659436,
-0.020777388,
-0.03375993,
0.0112666115,
-0.018649101,
-0.0044228435,
0.016081858,
-0.020471446,
0.008180598,
-0.018329859,
0.008699367,
-0.040144786,
-0.021947945,
0.0021116582,
-0.015297052,
-0.0007889621,
-0.0034784167,
0.015257147,
-0.026177911,
0.015709408,
0.027375072,
0.017279018,
-0.008626208,
0.017398734,
-0.019899469,
-0.010401996,
0.04926981,
-0.011559251,
-0.0151773365,
-0.0037976594,
0.017265717,
-0.015270448,
0.002191469,
0.0115925055,
0.013993477,
-0.020484747,
-0.02363727,
-0.054962974,
0.0011123618,
0.00087625504,
-0.007415745,
0.01773128,
-0.015257147,
0.0049981456,
0.0012694891,
-0.019886168,
-0.00034709345,
-0.006394833,
-0.012962589,
-0.019367399,
-0.0067872354,
-0.02146908,
-0.015602993,
0.02809337,
-0.013315086,
0.017199207,
0.013953572,
0.0039772335,
-0.00570314,
0.0058394833,
0.012317453,
-0.02355746,
-0.008779177,
-0.011506043,
-0.0013185394,
0.008220503,
0.014844792,
0.0011821961,
-0.041102514,
-0.005270832,
0.006334975,
-0.0023461021,
-0.020232014,
-0.02109663,
0.023118502,
0.008300314,
0.02705583,
-0.04360325,
-0.022493318,
-0.0048917313,
0.014020081,
-0.012556884,
0.0041268785,
-0.038282536,
0.013128862,
-0.0019354096,
-0.013102258,
0.050121125,
0.032882012,
0.015696106,
-0.020524653,
-0.033041634,
-0.0023727058,
-0.006680821,
0.013481359,
0.009164929,
-0.01975315,
0.006142099,
0.015749313,
0.008958752,
0.025885273,
-0.0037610796,
0.010488457,
-0.011426233,
-0.0011547612,
-0.0067938864,
-0.02303869,
-0.0110005755,
0.000824295,
0.023690479,
-0.011053783,
-0.0011023853,
0.008313616,
-0.0025423036,
0.0102290725,
-0.01058157,
0.004785317,
0.0014914626,
-0.010268978,
-0.011758777,
0.021881435,
0.039320074,
-0.036500096,
-0.011273262,
0.0085264435,
-0.013175418,
-0.0020484747,
0.018462878,
0.040809873,
0.006657543,
0.014658567,
-0.004196713,
0.004808595,
0.0012345719,
0.010535013,
0.008067532,
0.026603568,
-0.015097526,
0.022706145,
0.008207201,
-0.028066766,
-0.0055867494,
0.040437426,
-0.021056725,
-0.028359404,
0.0004863465,
0.011492742,
0.020737482,
-0.009430965,
0.015137431,
0.0036114345,
-0.015323656,
0.012503677,
0.000019848756,
-0.009929782,
-0.011659014,
0.021788323,
0.017997315,
0.008599604,
-0.018383067,
0.013321737,
0.021881435,
-0.0122975,
0.03346729,
-0.026271025,
0.01759826,
-0.0010317196,
0.02124295,
0.0022895697,
-0.015616295,
0.0020135576,
0.0007993541,
-0.0058860397,
-0.015935538,
0.028146576,
-0.0126766,
0.08380124,
0.009597237,
-0.016627232,
0.01960683,
-0.026656777,
0.02720215,
0.0034784167,
0.0027850613,
-0.0061687026,
-0.004130204,
0.013687536,
-0.036925755,
0.015908934,
-0.026044894,
-0.024794526,
0.025699047,
-0.02117644,
0.019194474,
-0.0017092794,
-0.01782439,
0.0238501,
-0.01483149,
-0.0019503741,
-0.0013850483,
-0.021269554,
0.0029929015,
0.0025356526,
-0.015243845,
-0.004243269,
-0.0071098036,
0.0087924795,
-0.006963484,
-0.05419147,
-0.0019653386,
-0.0088523375,
0.004402891,
-0.007841402,
-0.023796892,
0.017146,
0.011146896,
-0.0020401613,
-0.0068637207,
0.011206754,
0.002695274,
0.030062033,
0.0017641492,
-0.000894545,
-0.0024275756,
0.0010159238
] |
We evaluated oral 1,25-vitamin D3 for as long as 26 months in six prepubescent children with renal osteodystrophy previously treated with vitamin D2. Therapy was given at 14 to 41 ng per kilogram per day to correct hypocalcemia and reverse bone disease. Serum levels of 1,25-vitamin D3 were initially reduced at 15 +/- 5 pg per milliliter (mean +/- S.E.M.) and after treatment rose to 54 +/- 13. Serum calcium rose from 7.5 +/- 1.6 mg per deciliter (mean +/- | [
0.002398913,
-0.019437512,
0.019437512,
-0.033199273,
-0.017765887,
0.031385105,
-0.029648686,
-0.031929355,
-0.0138135925,
0.009653965,
0.023312056,
0.02235314,
-0.006867921,
-0.00010184447,
-0.029363602,
-0.005601243,
0.039134193,
-0.009433673,
0.01828422,
0.006705942,
-0.018608179,
-0.014163468,
-0.010949799,
-0.0073603382,
-0.003812992,
-0.013800634,
0.019865138,
-0.027212517,
0.018958054,
-0.037242275,
0.015044635,
-0.01593876,
0.007302026,
-0.007859235,
-0.008805193,
0.02039643,
-0.024905933,
-0.02586485,
0.006148733,
-0.016871762,
0.007101171,
-0.0063042333,
0.011189528,
-0.02219764,
-0.0021672826,
-0.0026370226,
0.01735122,
-0.026849685,
-0.02210693,
0.011532924,
-0.013308217,
0.009602131,
0.0011208965,
0.00523517,
-0.009822424,
0.007872193,
0.02227539,
0.02000768,
-0.01742897,
-0.016832886,
-0.01946343,
0.0008690188,
-0.017882511,
-0.00071311375,
-0.012653821,
0.0050310763,
0.002407012,
0.029259935,
0.009705798,
0.0022353139,
0.027782684,
0.03633519,
-0.009077318,
-0.011941112,
0.03125552,
-0.008921819,
-0.0034436793,
0.0051768576,
0.018413804,
-0.012524238,
0.021083223,
-0.011319112,
-0.031851605,
0.029726436,
0.013502592,
-0.004415555,
-0.013852468,
0.039108276,
-0.0062880353,
-0.017714053,
0.009342965,
0.01227155,
0.025929643,
0.004049482,
-0.025178058,
0.012090133,
0.0274976,
0.039833944,
-0.023143599,
-0.0035667836,
-0.023402765,
-0.020642638,
0.007684297,
-0.01626272,
-0.042788446,
0.0061552124,
-0.024815224,
-0.001993965,
0.015666636,
-0.01282228,
-0.034728356,
0.07396621,
0.014966885,
-0.01845268,
0.016768094,
-0.0013314696,
0.0046066907,
0.015692553,
0.013930217,
0.014915052,
0.0052740453,
0.006281556,
0.018167594,
-0.018724805,
0.024828183,
-0.0007673768,
-0.01711797,
-0.020176139,
-0.010483298,
0.008241505,
-0.00036830036,
0.010185257,
0.02142014,
0.0010148002,
-0.036698025,
0.01680697,
-0.0067189,
-0.012433529,
-0.010949799,
-0.033173356,
0.0063657854,
0.008053609,
-0.0013492873,
0.000035458273,
-0.0034404397,
0.006605515,
-0.0068873586,
-0.0012399514,
-0.026214726,
-0.01742897,
-0.007327942,
-0.016444135,
-0.0017542355,
0.00031545464,
0.015070552,
-0.022534557,
0.0074834423,
0.025527934,
-0.03540219,
-0.007587109,
-0.011001633,
-0.032784604,
-0.004538659,
-0.009168027,
0.012776925,
0.007574151,
0.021782972,
-0.0074380883,
0.012951863,
-0.011396862,
-0.007276109,
0.035920523,
-0.025592726,
-0.0007783104,
-0.017701095,
0.0016829646,
-0.005345316,
0.00265646,
-0.0051865764,
-0.007023421,
-0.026901517,
0.013684009,
0.014098676,
0.0146299675,
-0.02134239,
0.0097900275,
0.023921099,
0.008733923,
0.009906652,
-0.013891342,
0.018530428,
0.007554713,
-0.019631889,
-0.022495681,
-0.64148974,
-0.010016798,
-0.009854819,
0.006275077,
0.032162603,
0.03117777,
0.0055267327,
-0.007159484,
-0.0018854387,
0.013696968,
0.010321319,
0.019593013,
-0.019152429,
-0.01890622,
-0.0058150557,
-0.029000768,
-0.024711559,
-0.038641777,
0.015822135,
-0.024659725,
-0.028041853,
0.006705942,
-0.0137488,
0.018983971,
0.031488772,
0.01906172,
0.004742753,
-0.026370225,
0.008409964,
0.037760608,
-0.014215301,
0.023545308,
0.017403053,
0.027393935,
0.041440777,
-0.027601268,
0.00021826707,
0.004742753,
-0.017921386,
0.037890192,
-0.038849108,
0.017623344,
0.034676522,
0.016003553,
-0.040430028,
-0.0027001945,
0.009984402,
0.010768382,
0.013347092,
0.00547166,
0.028534269,
-0.00048796256,
-0.013839509,
-0.03757919,
0.0055591287,
-0.009537339,
0.005267566,
-0.025191016,
0.02086293,
0.0019129752,
-0.0139950095,
0.011759696,
0.01882847,
-0.01109882,
0.0030209133,
0.022949224,
0.0037028461,
0.027057018,
0.008967172,
0.027756767,
0.018167594,
0.019942889,
0.00025997675,
0.0043831593,
0.030270686,
-0.014798426,
0.009323527,
-0.0015971157,
-0.012537195,
0.020435305,
-0.0112413615,
0.003540867,
-0.023791516,
0.010748944,
0.04195911,
0.014020926,
-0.024750434,
0.009433673,
0.012595508,
-0.0026370226,
0.024737475,
0.008098964,
0.00041588178,
-0.042736612,
-0.0035667836,
0.016962469,
0.012997217,
0.015446343,
-0.0015258448,
-0.015873969,
-0.026797852,
0.012057737,
-0.0053485557,
-0.0136321755,
0.013249905,
-0.008688568,
-0.045587447,
-0.00083257345,
0.03532444,
-0.04633903,
-0.0059511187,
-0.018698888,
-0.02555385,
0.010133423,
0.017092053,
-0.0082155885,
-0.016599637,
-0.01273805,
-0.01968372,
-0.0059835142,
0.015796218,
0.0027617465,
0.035376273,
0.011545883,
-0.006164931,
0.00750288,
0.0008722584,
0.008921819,
0.0017186,
-0.020137263,
-0.004389638,
0.024478307,
0.028897103,
-0.029415436,
0.021588597,
-0.001625462,
0.024556058,
-0.013528509,
0.012537195,
-0.016249761,
-0.013074967,
-0.009550298,
0.003250924,
-0.002445887,
0.022262432,
-0.012550154,
0.000039862087,
0.011442216,
-0.0037935546,
0.024750434,
-0.009589173,
-0.009349444,
-0.0060321083,
0.004642326,
-0.012556633,
-0.01595172,
-0.0027180123,
-0.0143578425,
-0.002695335,
-0.01649597,
0.014681801,
-0.003485794,
-0.023959974,
-0.012103091,
-0.011895758,
-0.013787676,
-0.0006847674,
0.018724805,
0.0005985134,
-0.027134769,
-0.009491986,
-0.005147701,
-0.01648301,
-0.004914451,
0.0013120321,
0.0139043005,
-0.007172442,
-0.007982339,
0.00085039117,
0.00461317,
-0.00851363,
-0.014642926,
-0.028041853,
0.0035441066,
0.029907852,
0.008494193,
-0.0008738782,
0.02039643,
0.0076000676,
0.03260319,
-0.0016538084,
0.010386111,
-0.016068343,
0.018465636,
0.009219861,
-0.046287198,
-0.00789163,
-0.010612882,
0.02047418,
0.014746593,
0.017299386,
-0.004237378,
0.036231525,
-0.008934776,
0.011183049,
-0.0028816112,
-0.0013687249,
-0.0026516006,
0.043876946,
0.0019275533,
0.0027698455,
-0.0037320026,
0.011675466,
-0.011293195,
-0.024258016,
0.021757055,
-0.012900029,
-0.01477251,
-0.0065115667,
-0.008708006,
0.007988818,
-0.028404685,
0.03729411,
0.0021608034,
-0.02110914,
0.01547226,
0.008746881,
-0.016858803,
0.012796363,
0.0022126369,
-0.027990019,
-0.013133279,
-0.022534557,
-0.011766175,
0.007282588,
0.0111506535,
0.010820216,
-0.027730852,
-0.006113098,
0.02086293,
0.01649597,
0.0085784225,
0.03086677,
-0.0044090757,
-0.008455318,
-0.019165387,
0.020772222,
0.004953326,
-0.016068343,
0.03125552,
0.019009888,
0.009861298,
0.0031051426,
0.0031585959,
-0.0068808794,
0.0118828,
0.0070363795,
0.019333847,
0.017610386,
0.034210023,
0.034650605,
0.030581687,
0.019476388,
-0.019282013,
0.0046909195,
0.019865138,
0.0029107674,
0.016534844,
-0.013567384,
-0.02649981,
-0.042529278,
-0.019411596,
0.013969093,
-0.018556345,
0.0032995178,
0.007088213,
0.015588885,
-0.0017315585,
0.012543675,
0.03726819,
-0.010256528,
-0.008798714,
0.022949224,
0.014422635,
-0.013774717,
0.0038551067,
-0.017960262,
-0.006867921,
0.010036236,
-0.0067642545,
-0.004681201,
-9.5226096e-7,
0.002782804,
0.002055517,
-0.03540219,
-0.02173114,
0.003297898,
-0.0033886065,
0.011170091,
0.0018352251,
0.0024037724,
-0.010198215,
-0.0025430745,
-0.004626128,
0.009679881,
-0.0030857052,
-0.01789547,
-0.01578326,
-0.01148109,
0.0020036837,
0.0055915243,
-0.00546842,
0.0027147727,
0.009420714,
0.00820263,
-0.0014634827,
0.0017963501,
0.007613026,
0.024037724,
-0.027057018,
-0.0109692365,
-0.021951431,
-0.005018118,
-0.010723028,
0.019269055,
0.0055785663,
0.029726436,
0.020927722,
0.01071007,
0.01078134,
0.011221924,
-0.010509215,
0.010509215,
0.008403485,
0.00929761,
0.021122098,
0.0052319304,
0.012187321,
-0.016379343,
0.027342102,
0.0061908476,
-0.014422635,
-0.006132535,
-0.013696968,
0.00898661,
0.028637936,
0.028275102,
0.05955654,
0.028482435,
-0.012828758,
0.013411884,
0.03439144,
0.019346805,
-0.02344164,
-0.01031484,
0.012511279,
0.01125432,
0.021277597,
-0.0043572425,
-0.033043772,
-0.014163468,
0.007230755,
0.020150222,
0.012154925,
0.021160971,
0.016042428,
-0.0071854005,
0.0014399957,
0.010904444,
-0.012725092,
-0.0002134077,
0.019670762,
0.0036380545,
-0.012090133,
0.021977348,
0.010729507,
0.0007823599,
-0.018543387,
-0.010593444,
0.009174506,
0.01680697,
-0.0011678706,
-0.014370801,
0.009472548,
-0.008409964,
-0.029519103,
0.0012083654,
-0.0006556111,
-0.012608467,
-0.00484318,
-0.019787388,
0.012621425,
0.012783404,
0.0018157876,
-0.009764111,
-0.006602275,
-0.028897103,
-0.0060774623,
0.0054748994,
-0.01539451,
0.014215301,
-0.007379776,
0.016547803,
-0.000113183014,
-0.020538973,
0.0042535756,
-0.023014015,
-0.018219428,
0.009828902,
0.019346805,
0.0132693425,
-0.00019012317,
-0.018867346,
-0.01891918,
0.015575927,
0.028015936,
0.0019405117,
-0.01547226,
-0.026240643,
-0.034883857,
0.015912844,
0.013191592,
-0.0037773566,
-0.014733635,
-0.0049760034,
-0.0030759864,
-0.007697255,
-0.028560186,
-0.010120465,
0.006265358,
-0.0121808415,
0.016781053,
0.016288636,
-0.04071511,
-0.0076713385,
-0.0039101797,
-0.008630255,
-0.0071141296,
0.024957767,
0.013308217,
-0.009479027,
-0.010353715,
0.01321103,
0.0054587014,
0.0019405117,
-0.010846132,
0.035039358,
-0.040974278,
-0.029622769,
0.00077466585,
0.018608179,
-0.026318392,
-0.018530428,
-0.004250336,
0.02156268,
0.010211173,
-0.02595556,
-0.024672683,
-0.02524285,
-0.009388318,
-0.015511136,
0.00023750211,
0.016897678,
-0.012051258,
0.0008763079,
0.013943176,
-0.018025054,
-0.013528509,
0.018880304,
-0.019813305,
0.0055072955,
-0.029493187,
0.00041912138,
0.0015663395,
-0.016470052,
-0.004477107,
-0.025657516,
0.0095179025,
0.018971013,
-0.0048496593,
0.019035805,
0.016677385,
-0.00218834,
0.01195407,
0.056705706,
-0.02016318,
-0.021005472,
0.0046682428,
0.006070983,
0.0024944807,
0.004237378,
0.012997217,
-0.029285852,
-0.008390526,
0.010982195,
-0.003625096,
0.0254761,
-0.012938905,
0.013696968,
0.040663276,
-0.0062588793,
-0.02179593,
-0.010496257,
-0.0132693425,
-0.0142671345,
-0.00835813,
0.0009232819,
0.012543675,
0.020020638,
-0.008967172,
0.04501728,
0.011228403,
0.010580486,
-0.03024477,
0.008157277,
-0.029648686,
0.010282444,
-0.004674722,
-0.006048306,
0.017765887,
-0.005517014,
0.0038615859,
-0.02258639,
0.0008447219,
0.0033464918,
0.0032557833,
0.013126801,
0.0030354916,
-0.00648889,
-0.00086415943,
-0.010437944,
-0.030270686,
-0.016625553,
-0.021070264,
-0.010230611,
0.021549722,
0.0030597884,
-0.0065634004,
0.008098964,
0.00021320522,
-0.01828422,
0.01882847,
-0.006126056,
-0.013062009,
0.01047034,
-0.03335477,
0.0271866,
-0.027860435,
0.03672394,
0.028041853,
0.006184369,
-0.01586101,
-0.019074678,
0.00038733293,
-0.0137488,
0.042088695,
0.034572855,
-0.025813017,
-0.011319112,
-0.007470484,
0.014137551,
-0.005400389,
-0.045613363,
0.017143887,
-0.0042632944,
-0.016845845,
-0.0065050875,
0.015381551,
-0.0062264833,
0.030426187,
0.0063722646,
-0.02399885,
-0.0017299387,
0.0023972932,
-0.03617969,
0.036853526,
-0.009083797,
0.023558265,
0.01008159,
0.007172442,
-0.020279804,
-0.028974852,
-0.017390095,
0.033199273,
-0.01657372,
0.029104436,
-0.0126343835,
0.028275102,
-0.014137551,
-0.0133600505,
-0.009945528,
-0.012407612,
-0.04268478,
0.02954502,
-0.0052708057,
0.002470184,
0.034002688,
0.008623777,
-0.008228547,
-0.0042179404,
-0.01946343,
-0.0042017424,
-0.061629873,
-0.0020976316,
0.028378768,
0.034650605,
-0.016236803,
0.0033157158,
-0.010729507,
0.004046242,
-0.00804713,
-0.021433098,
0.0033724084,
-0.032940105,
-0.0048950138,
-0.008863506,
0.0031310595,
-0.0044285133,
-0.0071789213,
-0.011500528,
0.0035667836,
0.00016876216,
-0.029830104,
0.037501443,
0.025761183,
0.02524285,
-0.025489058,
-0.025579767,
-0.025048476,
-0.034443274,
0.010826695,
-0.0022320743,
-0.041699946,
-0.0050602327,
-0.026344309,
0.007120609,
-0.005069951,
-0.029570935,
0.023091765,
0.0071789213,
0.025463142,
0.0025495538,
-0.018724805,
0.021070264,
0.014228259,
-0.018128721,
-0.020538973,
-0.017493762,
0.003336773,
-0.0028929499,
0.009705798,
-0.008539547,
-0.01031484,
0.02462085,
-0.03620561,
0.020487139,
-0.01992993,
-0.01093684,
-0.032784604,
0.012310425,
-0.020888846,
0.03187752,
0.018465636,
-0.017519679,
0.015731428,
0.0034112835,
0.022573432,
0.0061616916,
0.009323527,
0.0008167805,
-0.0061876085,
-0.027990019,
-0.018621137,
0.007172442,
-0.009407756,
0.036594357,
0.015226052,
-0.016819928,
0.0057794205,
-0.017364178,
-0.035583608,
0.0012715373,
0.0024167309,
-0.0065439628,
0.014733635,
0.01750672,
0.013249905,
0.03086677,
-0.030270686,
0.016068343,
-0.027290268,
-0.015070552,
0.0073603382,
0.003641294,
0.025968516,
0.013308217,
-0.035298523,
0.02210693,
0.016107218,
-0.011118257,
0.0028897102,
0.013528509,
0.010450902,
0.0053323577,
-0.013606259,
0.018724805,
0.019074678,
-0.0020927722,
0.0023875744,
-0.018167594,
0.0027957621,
-0.003171554,
0.00022211407,
-0.011591237,
-0.026396142,
-0.008500672,
-0.01814168,
0.0034436793,
-0.019217221,
0.006926234,
0.0020927722,
-0.016638512,
0.005008399,
0.036153775,
-0.004869097,
-0.0117273,
0.02322135,
0.012096612,
0.020577846,
0.019256096,
-0.015420427,
-0.0033691688,
0.008157277,
0.007651901,
0.010923882,
0.0006438676,
0.0025657518,
-0.018025054,
0.014733635,
0.015666636,
0.0019502304,
-0.013580342,
0.03690536,
0.019048763,
-0.013295258,
0.0003367144,
0.0069521503,
-0.013262863,
0.0017493762,
-0.016016511,
-0.014241218,
-0.027653102,
-0.03744961,
0.024232099,
-0.02453014,
-0.014059801,
0.028404685,
-0.015977636,
-0.0015776781,
0.018841429,
0.19136879,
0.009258735,
-0.009245777,
0.024944808,
0.0033335334,
0.010418507,
0.02289739,
0.015692553,
0.0054133474,
0.007949943,
0.04188136,
-0.004499784,
-0.008144318,
-0.0024134913,
0.008170235,
-0.008584902,
-0.01071007,
-0.028741602,
-0.013016654,
-0.007101171,
0.0055299723,
0.0013500972,
0.0010382872,
0.0036672107,
0.020875888,
0.013334134,
-0.01093684,
0.0052999617,
0.016845845,
0.010360194,
-0.009602131,
0.0009597272,
-0.003916659,
0.0071854005,
-0.012608467,
-0.016146094,
-0.0007451047,
-0.039315607,
-0.006087181,
0.023014015,
-0.019320888,
-0.010269486,
-0.04548378,
-0.028352853,
0.004674722,
0.029752353,
0.0041693463,
-0.019256096,
-0.030814936,
0.026823768,
-0.013133279,
-0.00679665,
0.039756194,
0.025437225,
-0.0034760751,
-0.013249905,
0.01961893,
0.0020134023,
-0.004901493,
0.01023709,
0.0020749546,
-0.0053712325,
0.0025446943,
0.043021694,
-0.020500097,
0.025722308,
-0.0056465976,
-0.00945311,
-0.009239297,
-0.019022847,
0.0069651087,
-0.011040507,
-0.014176426,
0.017908428,
0.005426306,
-0.0058182953,
0.018867346,
0.019424554,
-0.016470052,
-0.011597716,
-0.013852468,
-0.011293195,
-0.010852612,
0.013878384,
-0.03335477,
-0.021705223,
-0.0036121379,
0.027601268,
0.001226993,
0.001086071,
0.01992993,
-0.018711846,
-0.0063107125,
0.015731428,
0.0074445675,
-0.010185257,
-0.010891486,
0.0074121715,
0.0017283189,
-0.0076907757,
0.006472692,
0.056913037,
-0.005461941,
0.01547226,
-0.0009961725,
0.00085120107,
-0.012640863,
0.011830966,
-0.018556345,
0.007859235,
0.016003553,
-0.05071895,
0.020720389,
-0.0143578425,
0.0012545295,
0.0015339437,
-0.015109426,
-0.038849108,
-0.0047945864,
-0.0076000676,
0.018763678,
-0.038486276,
0.0014480947,
0.036983106,
-0.038978692,
-0.003932857,
-0.02533356,
0.008066568,
-0.0024232098,
-0.03330294,
0.006508327,
-0.025514975,
0.000035508892,
0.044265695,
-0.00031363236,
0.0013719645,
-0.0034210023,
0.0030824656,
0.0052870037,
0.00035311482,
0.025307642,
-0.021070264,
0.020448264,
0.004188784,
0.017247554,
-0.04843828,
0.023299098,
-0.019839222,
-0.004127232,
0.004013846,
-0.034650605,
0.006135775,
-0.010224132,
-0.012621425,
0.008384047,
-0.0008868365,
-0.02134239,
-0.03086677,
-0.0025754704,
0.0067318585,
-0.0014432353,
0.0012861154,
0.012997217,
-0.008701527,
-0.02024093,
0.013476675,
-0.16130544,
0.00088035734,
0.037553273,
-0.020759264,
0.0028249186,
0.012187321,
0.049993284,
0.0071400465,
0.010496257,
0.00003897626,
0.009647486,
0.026694184,
-0.02070743,
-0.027471684,
0.01039259,
-0.0110599445,
-0.00040474572,
0.020202056,
0.022871474,
0.017752929,
0.04781628,
0.012103091,
0.015666636,
-0.02892302,
0.007898109,
0.0110599445,
0.01845268,
-0.009291131,
0.028326936,
0.004133711,
-0.018530428,
0.019437512,
0.0059187226,
-0.0081248805,
0.00867561,
-0.03397677,
0.0021122098,
0.01836197,
-0.011144174,
0.015977636,
0.001789871,
0.015096468,
0.017105011,
-0.015446343,
-0.015912844,
0.029130353,
0.000021411635,
-0.010859091,
0.012161404,
-0.02148493,
0.026033308,
-0.023117682,
0.015420427,
0.008163756,
-0.0050926283,
0.0139043005,
0.00445767,
0.03620561,
0.0016635271,
-0.016366385,
-0.0056563164,
-0.023493474,
0.01665147,
-0.014889135,
0.004937128,
-0.03268094,
-0.004953326,
-0.014902093,
-0.006142254,
0.026668267,
-0.0532847,
-0.033406604,
-0.016703302,
0.011688424,
0.0051865764,
-0.00060053816,
-0.004072159,
-0.03353619,
-0.004318367,
0.011552362,
0.0085784225,
0.007872193,
-0.019385679,
0.0035538252,
-0.051237285,
0.027730852,
0.011539403,
0.027679019,
0.0031990907,
-0.00022798583,
-0.0037838358,
-0.043799195,
-0.0029059083,
-0.009446631,
0.008733923,
0.006673546,
0.00742513,
0.021160971,
0.0026888559,
-0.0245431,
0.03446919,
-0.016418219,
-0.013684009,
0.006142254,
0.04032636,
-0.020098388,
0.0034501585,
-0.0034274815,
0.011895758,
-0.00750288,
0.019878097,
0.0055299723,
0.006025629,
-0.012627904,
-0.027653102,
0.01492801,
-0.02642206,
-0.008034172,
0.008040651,
-0.014215301,
0.031955272,
0.00570491,
-0.03032252,
0.0019324127,
-0.0003274006,
-0.0084877135,
-0.11683241,
0.00734738,
0.007625984,
0.025359474,
0.00914211,
0.021847764,
0.004937128,
-0.013165675,
-0.00052157324,
0.02101843,
-0.018167594,
-0.02398589,
-0.007807401,
0.0076000676,
0.028430602,
-0.012135487,
0.007587109,
-0.025838934,
-0.022949224,
0.03190344,
0.0040527214,
-0.006297754,
0.010353715,
-0.010386111,
-0.026072184,
-0.014733635,
-0.023947015,
0.018465636,
0.017623344,
0.0132823,
0.01578326,
0.008727443,
0.01649597,
-0.0040365234,
-0.03566136,
0.0053032013,
-0.015303802,
-0.0027228715,
0.011921675,
-0.01109882,
0.01039259,
0.022068055,
0.007509359,
0.010723028,
0.021821847,
-0.0021656628,
-0.036672108,
-0.016288636,
-0.00024884066,
-0.007807401,
-0.013878384,
-0.0028621738,
-0.018323096,
0.0013419982,
0.012323383,
-0.016508928,
0.0039198985,
-0.013930217,
0.011280237,
-0.0041693463,
-0.018971013,
0.0135414675,
-0.021238722,
0.014668843,
-0.0014732014,
-0.00968636,
0.0024329287,
-0.016664427,
-0.0068355254,
-0.01148109,
-0.00929761,
-0.003320575,
0.011260799,
-0.0019874857,
-0.017778846,
0.015588885,
0.0025916684,
-0.004188784,
0.00081111124,
-0.010016798,
-0.009660444,
0.0032784606,
0.0086691305,
0.007431609,
0.0032233875,
0.01555001,
0.014409676,
0.011733779,
0.0076778177,
-0.018893262,
-0.03133327,
0.014655884,
-0.006751296,
-0.009589173,
-0.012116049,
0.01891918,
0.011675466,
-0.0059122434,
0.01571847,
0.002141366,
-0.03470244,
-0.022703014,
-0.0504857,
0.023428682,
0.030063353,
-0.027057018,
0.00016532009,
-0.037086774,
0.006245921,
0.0009807845,
0.023519391,
-0.004509503,
-0.0152649265,
-0.0035603044,
-0.034132272,
0.013671051,
-0.02070743,
0.0084877135,
0.008766319,
0.0077231717,
0.025268767,
0.019113554,
0.003501992,
0.016871762,
0.010645278,
0.01758447,
-0.008416443,
0.00048350813,
0.0039652525,
0.005134743,
-0.0017040219,
-0.013133279,
0.0043248464,
-0.052559033,
-0.0076454217,
0.018439721,
-0.0060385875,
-0.005410108,
-0.013347092,
0.028534269,
0.018465636,
0.0058312537,
-0.0027406893,
-0.04055961,
0.026979268,
0.0045062634,
0.0047168364,
0.023636015,
-0.02031868,
0.0046973987,
-0.025346518,
-0.020979555,
0.016871762,
0.0147206765,
0.010133423,
-0.0078527555,
-0.019813305,
0.0044706278,
-0.017377136,
0.0040689195,
0.017014302,
-0.006220004,
0.0046358467,
-0.0042470964,
-0.017545596,
-0.019735554,
0.010496257,
-0.014785468,
-0.000119864664,
0.004823743,
-0.0006438676,
-0.014707718,
-0.023921099,
0.020901805,
0.0046066907,
0.010619361,
0.0033562107,
-0.0036477733,
-0.006932713,
0.022288349,
0.003305997,
0.0022450327,
0.0037935546,
-0.013003696,
-0.014318968,
0.02430985,
0.0090643605,
0.027290268,
0.0026289236,
0.018025054,
0.007094692,
0.003501992,
-0.010457382,
0.001750996,
-0.00031363236,
0.017066136,
0.0068355254,
0.017532637,
0.0028540748,
-0.001101459,
0.00081475574,
0.009939048,
-0.006352827,
-0.0025382151,
0.008714485,
-0.011902237,
-0.015213094,
-0.013709926,
-0.029830104,
-0.03306969,
-0.019217221,
0.004771909,
0.005069951,
0.008157277,
0.030167019,
0.017001344,
0.0046228883,
0.003689888,
0.020979555,
-0.002313064,
-0.014228259,
0.027704936,
-0.007535276,
0.02289739,
0.0021462254,
-0.004004128,
0.01828422,
0.0076907757,
0.009621569,
0.002437788,
0.025618643,
-0.007898109,
-0.021808889,
-0.0121938,
-0.02493185,
-0.004149909,
0.018089846,
-0.02954502,
0.021160971,
0.018038012,
-0.011208965,
0.07132272,
-0.025268767,
-0.02884527,
-0.0025284966,
0.0025463142,
0.023299098,
-0.006275077,
0.020046555,
-0.011260799,
-0.0016368006,
0.005957598,
-0.015666636,
0.026849685,
-0.016314553,
-0.027108852,
0.019722596,
0.028637936,
0.019191304,
-0.010820216,
0.0035765024,
0.012569591,
-0.007204838,
-0.0039911694,
0.0121938,
-0.023687849,
-0.014007968,
0.046779614,
0.004956566,
-0.0041531487,
-0.059504706,
-0.011941112,
0.030503936,
-0.03540219,
-0.0023406006,
0.020616721,
-0.03299194,
-0.01704022,
-0.020953638,
-0.012744529,
0.0023082045,
-0.016534844,
0.04517278,
-0.013878384,
-0.0013306597,
-0.028378768,
-0.024400558,
-0.015096468,
-0.012595508,
-0.011863362
] |
OBJECTIVES To assess the association between severity of neuropathy and disease stage, and estimate the rate of neuropathy progression in a retrospective cross-sectional analysis of a multinational population of patients with familial amyloidotic polyneuropathy (FAP). METHODS We characterize neuropathy severity and rate of progression in available patients with FAP in France, the United States, Portugal, and Italy. Neuropathy Impairment Scores (NIS), time from symptom onset to NIS measurement, polyneuropathy disability (PND) scores, FAP disease stage, and manual grip strength data were collected. We estimated neuropathy progression using | [
0.0037520062,
-0.017179169,
0.04328716,
-0.05094044,
-0.020815833,
0.015021595,
0.0062148967,
0.009152724,
-0.021792846,
-0.010808221,
-0.0038436013,
0.005326085,
0.017939068,
0.014763772,
-0.00616401,
-0.0063370233,
0.04141455,
0.004250691,
-0.0049427426,
0.014967316,
-0.029283289,
0.029826075,
-0.010543613,
-0.019241754,
0.0006322606,
0.0043388936,
0.007693988,
-0.034466892,
-0.014750202,
-0.02092439,
0.0144381,
-0.02428966,
0.0017157118,
-0.008894901,
0.00892204,
-0.016853496,
0.0002584593,
0.0016317496,
0.0047459826,
-0.031671546,
0.0075854305,
0.0035552464,
-0.008114646,
0.010645385,
0.0025375232,
-0.016907776,
-0.012151616,
-0.010604676,
-0.011873438,
0.032675702,
0.009417333,
0.012877591,
-0.0092341425,
-0.0060554533,
-0.004800261,
-0.026908603,
0.012307666,
0.017192738,
-0.018441144,
-0.013793542,
-0.0034517779,
0.02123649,
-0.023041254,
0.012823313,
-0.005753529,
-0.01042827,
0.0036773733,
-0.003122714,
0.0128029585,
-0.003377145,
0.040437534,
0.03726224,
-0.02925615,
-0.016934915,
0.036312364,
0.020625858,
0.01328468,
-0.026528653,
0.0034772211,
0.0147230625,
0.022335632,
-0.022620594,
-0.017626965,
0.015198,
0.008202849,
-0.006370947,
-0.007178341,
0.020775123,
-0.010095814,
-0.012076982,
0.015903622,
0.013773188,
0.0029123847,
-0.0032075243,
-0.0016868763,
0.0066118087,
-0.01369177,
0.010394347,
0.0022389912,
-0.0012670654,
-0.008569229,
0.015903622,
-0.023014115,
-0.016392129,
0.002898815,
-0.00893561,
-0.0019455475,
-0.008888116,
0.011276374,
-0.009770143,
-0.009458041,
0.016202154,
0.0021609657,
-0.013210047,
0.0027529413,
-0.014885899,
0.030450279,
0.011086399,
-0.010801435,
-0.00855566,
0.021942113,
0.01121531,
0.026135132,
0.007185126,
0.0155372415,
0.011561336,
-0.03224147,
-0.012769034,
-0.017084181,
-0.018400436,
0.006615201,
0.010156877,
0.043857086,
-0.017531978,
-0.010889638,
-0.0067203655,
-0.011303512,
-0.019133197,
-0.03156299,
-0.029853215,
0.01670423,
0.014953746,
-0.025972297,
0.0015206481,
0.0007492987,
0.033625577,
0.024574624,
0.013732479,
0.009790498,
-0.0029598784,
-0.0034840058,
-0.00561444,
-0.012090552,
-0.002205067,
-0.0022746115,
0.00025527892,
0.015116583,
0.03001605,
-0.026501512,
-0.021887833,
-0.036638036,
0.013528934,
-0.03471115,
-0.002980233,
-0.023814723,
0.017301295,
-0.012504426,
-0.020137351,
0.01518443,
-0.0023814724,
-0.021955682,
0.013264326,
-0.0182376,
0.026515082,
0.004006437,
-0.017667675,
0.012036273,
0.0024187888,
-0.018319018,
-0.024113256,
0.0014231163,
0.01176488,
0.020300185,
-0.011561336,
-0.00969551,
0.022267785,
0.043992784,
0.011337437,
-0.025673764,
-0.0070155053,
-0.00093460915,
0.0066830493,
-0.013793542,
-0.023054823,
-0.63875026,
-0.026053715,
0.023801154,
-0.008732066,
0.008969534,
0.032919955,
0.010407916,
0.0035382845,
-0.019431729,
0.04678813,
0.00655753,
0.03188866,
0.01935031,
-0.022213506,
-0.013793542,
-0.021155074,
-0.011269589,
-0.019689552,
0.018698968,
-0.01902464,
-0.02427609,
0.03574244,
-0.0011941285,
0.017979776,
-0.0023763836,
0.012674047,
0.013583213,
-0.010360423,
-0.0010745461,
0.007137632,
-0.021738568,
0.014397391,
0.00875242,
-0.0053464393,
0.05102186,
-0.021412896,
0.006126694,
0.025565207,
0.018101905,
0.02585017,
-0.019662412,
0.0041590957,
-0.0021541808,
0.0048613246,
-0.01350858,
0.01785765,
0.0049766665,
-0.0070087207,
0.016337851,
-0.011439209,
0.008888116,
0.017572688,
-0.009824421,
-0.00008221295,
0.027247842,
-0.0072394046,
0.014573797,
-0.016826358,
-0.0069306954,
0.003270284,
0.005817984,
-0.0037927153,
-0.0014494075,
-0.019445298,
-0.020381603,
-0.003667196,
-0.025782323,
-0.0120091345,
-0.0035891705,
-0.01593076,
0.0052243127,
0.024398219,
0.0023170165,
0.018834665,
0.034656867,
0.019160336,
0.0078025446,
0.024886725,
-0.03346274,
-0.022607025,
-0.01860398,
0.009966902,
-0.022281354,
0.0136171365,
-0.0025901056,
0.01941816,
-0.03500968,
0.035498187,
0.015320127,
-0.0014884202,
0.009417333,
0.000404757,
-0.014112429,
-0.027790628,
-0.030830229,
0.021996392,
-0.024995282,
-0.0029039036,
-0.011554551,
-0.016839927,
-0.0037587911,
-0.0041658804,
0.0050682616,
-0.019648843,
0.041305993,
0.017667675,
-0.0066762646,
0.032431446,
0.023380496,
-0.007422595,
0.0056551485,
-0.01865826,
-0.026664348,
-0.017559119,
-0.004457628,
-0.032160055,
0.021005807,
-0.009824421,
-0.012606198,
-0.011568121,
0.00038758293,
0.004138741,
0.008501382,
0.021412896,
0.0073276074,
0.01597147,
0.0034772211,
-0.0046543875,
0.0005758617,
-0.014560227,
-0.0024221812,
-0.012456932,
0.014153138,
-0.012545135,
0.019594565,
0.002683397,
0.0011110145,
-0.003979298,
-0.007680418,
-0.03986761,
-0.019323172,
0.00503773,
0.00048172232,
-0.0106318155,
0.004403349,
-0.01860398,
-0.0010194194,
0.004698489,
0.017192738,
0.018006917,
0.0019285855,
0.00308879,
-0.004915603,
0.022389911,
0.030993065,
-0.018712537,
0.0035891705,
-0.029337568,
-0.017179169,
-0.014248125,
0.0025069916,
0.0002245352,
-0.016093597,
-0.007945026,
-0.01935031,
-0.032485727,
0.00417945,
0.03224147,
0.0039759055,
-0.026148703,
-0.020286616,
-0.009125585,
-0.022525607,
0.0035043603,
-0.0024985105,
0.007117278,
0.014098859,
-0.034792565,
-0.008135001,
-0.008386039,
0.015415114,
-0.014275264,
-0.014913037,
0.0053396546,
0.05251452,
-0.0016868763,
0.010943917,
0.002272915,
-0.0061300863,
0.04062751,
-0.004186235,
0.025972297,
0.014315973,
0.017966207,
-0.051130414,
0.016147874,
0.004813831,
-0.0047968687,
-0.0072394046,
0.011778451,
0.030884508,
-0.0209651,
0.032784257,
0.00855566,
0.022688443,
-0.01825117,
0.02047659,
-0.028821921,
0.026935741,
0.0182376,
-0.0035111452,
0.007422595,
-0.00465778,
-0.01785765,
-0.022335632,
0.0020625857,
0.015862912,
-0.0021117758,
-0.0133253895,
0.0075854305,
-0.008535305,
0.003609525,
0.023068393,
0.022715582,
0.0009108623,
0.01749127,
0.0020269654,
0.03348988,
0.026474373,
-0.02540237,
-0.00010018213,
0.0105911065,
0.0068492773,
0.0153065575,
0.022891987,
0.017599827,
0.00892204,
-0.0025222574,
0.03300137,
0.026718628,
0.011635968,
0.019526716,
0.01253835,
0.0019404589,
-0.001701294,
-0.0068424926,
0.013155769,
0.02969038,
-0.008209634,
0.008202849,
0.0021049909,
0.016867066,
-0.01407172,
-0.004433881,
-0.0014646733,
-0.008664217,
-0.0053973254,
0.016554965,
0.01711132,
0.028659087,
0.037805025,
0.0039928677,
0.012517996,
0.0075107976,
0.004087855,
-0.035199653,
-0.017925499,
-0.016812788,
0.015021595,
-0.015523671,
-0.038592063,
-0.0019472438,
-0.01042827,
-0.008392824,
0.004688312,
-0.010373992,
0.014858759,
-0.000019758143,
0.046543874,
0.01006189,
-0.013684985,
-0.031780105,
0.0334356,
0.0075854305,
-0.013135415,
0.0025019029,
-0.0012017615,
0.016188584,
0.004104817,
-0.031725824,
0.00039436776,
0.005780668,
-0.0011568121,
-0.0010830271,
-0.019146767,
0.011663108,
0.031101622,
-0.015835773,
0.0100686755,
-0.015089443,
0.014153138,
0.0106318155,
-0.01217197,
-0.022132087,
0.022294924,
0.019187475,
-0.037370797,
-0.010720018,
-0.012287312,
-0.0017793195,
0.01631071,
-0.009973688,
0.0026647386,
0.029608961,
0.013963163,
-0.010394347,
-0.015442254,
-0.003461955,
0.04320574,
-0.001370534,
-0.0027851693,
-0.035633884,
-0.007822899,
0.01711132,
0.032431446,
0.027071439,
0.008745635,
0.0021830164,
0.013135415,
0.009478396,
0.003874133,
-0.0125315655,
0.04146883,
0.0048782867,
0.009919409,
-0.0074429493,
0.021331478,
0.012755465,
0.012836882,
0.02656936,
0.01484519,
-0.035633884,
0.013895314,
0.014478809,
-0.007565076,
-0.016473547,
0.031671546,
0.023787584,
-0.0046136784,
-0.006896771,
0.0035722086,
0.0062997066,
-0.0025052954,
-0.015048734,
-0.018359726,
0.00213213,
-0.011507058,
0.019296031,
-0.03004319,
0.0045627924,
0.021331478,
0.0075311516,
0.012870806,
-0.00060088077,
0.03376127,
-0.013922454,
0.011479918,
0.0030192456,
0.03186152,
0.007551506,
-0.011561336,
0.0044067414,
-0.0018624335,
-0.012775819,
0.01632428,
-0.0063743396,
-0.007578646,
-0.004922388,
0.013440731,
-0.0002535827,
0.012748679,
-0.0072122654,
0.0057501364,
-0.013752833,
-0.012321236,
0.0017962815,
0.015387976,
-0.007917887,
-0.036312364,
-0.031725824,
-0.023638317,
-0.009471611,
0.0023662066,
-0.011140677,
0.012117691,
-0.011995564,
-0.01598504,
-0.001312863,
0.010645385,
-0.0016113952,
0.006574492,
-0.012138045,
0.011188171,
0.000479178,
-0.0051971735,
0.0037384366,
-0.0022169405,
0.0031108407,
0.022756292,
0.024832446,
-0.00030764926,
-0.018834665,
-0.0030175494,
-0.010876069,
0.018115474,
-0.0205173,
0.021928543,
0.006516821,
-0.013596782,
-0.016229292,
0.021955682,
0.015198,
-0.019106057,
-0.01901107,
0.020422313,
-0.04418276,
-0.008392824,
-0.0350911,
0.0028224858,
0.005254844,
-0.0033601827,
-0.010794651,
0.021100795,
-0.03994903,
0.0055771233,
0.0006267479,
0.010753942,
0.0003519626,
0.014031011,
0.04095318,
-0.022159226,
0.011059259,
0.029473264,
0.02209138,
0.00009641868,
0.009932979,
0.029364707,
0.004813831,
-0.035850998,
0.027614223,
0.0034585628,
-0.026691487,
-0.025429511,
0.0036298796,
0.0029463088,
0.048389345,
-0.008487811,
-0.037370797,
-0.008576014,
-0.008596369,
-0.031020204,
-0.020408744,
-0.006910341,
-0.007117278,
0.0016334457,
-0.012477287,
0.00817571,
0.01594433,
0.04784656,
-0.040193282,
-0.009220572,
0.0060588457,
0.009600522,
0.021792846,
-0.023353355,
-0.0010050017,
-0.02317695,
0.00088033057,
-0.035416767,
0.0053871484,
0.016839927,
0.007666848,
0.02017806,
0.032431446,
0.022674873,
0.010665739,
-0.027193565,
0.029391848,
-0.00006647005,
0.023679027,
-0.004301577,
-0.016500685,
0.001808155,
0.034059804,
0.0014553443,
0.0026443843,
0.0060927696,
-0.042147312,
0.0066932263,
0.02739711,
-0.005936719,
-0.03272998,
-0.021372188,
-0.055689815,
-0.007639709,
0.012429793,
0.006011352,
0.019499578,
-0.05053335,
-0.0147230625,
-0.014085289,
0.0027241057,
0.014750202,
-0.028034883,
0.021141503,
-0.008976319,
0.025728043,
0.015252279,
0.0009151028,
-0.0048104385,
-0.012070198,
-0.0038843104,
-0.0015944331,
-0.009620877,
-0.023896141,
0.010489334,
-0.007110493,
0.0032601068,
0.0033059043,
0.016758509,
-0.028034883,
-0.015469393,
-0.016894206,
-0.015170861,
-0.0020439276,
-0.009994042,
-0.011602045,
-0.02931043,
0.017328434,
0.0033245625,
-0.014193847,
0.009824421,
-0.028360553,
-0.029066175,
0.00017078668,
-0.013135415,
-0.00780933,
-0.019933805,
0.024072547,
0.036638036,
-0.014356682,
-0.05175462,
0.0014519518,
0.004104817,
-0.0046713497,
0.04258154,
0.018061195,
-0.014695924,
-0.01867183,
0.008806698,
0.011106753,
-0.022607025,
-0.05316586,
0.03796786,
0.0054651736,
0.021195782,
-0.011703817,
-0.0030514735,
-0.03118304,
0.040736068,
-0.023339786,
-0.004467805,
-0.006442188,
-0.020992238,
-0.0139088845,
0.023299078,
-0.0167178,
0.007266544,
-0.000116402094,
-0.01822403,
-0.0054007177,
-0.018210461,
0.019703122,
0.0037520062,
0.000064190775,
0.014207416,
0.0073276074,
0.003941981,
-0.010801435,
0.008440318,
0.005366794,
-0.0025460043,
-0.01197521,
0.0364752,
-0.01559152,
-0.017816942,
0.0036366642,
-0.000071240625,
-0.000033977114,
-0.010000827,
-0.010102599,
-0.017464131,
-0.022539178,
0.014248125,
0.020612288,
-0.010950702,
-0.021155074,
0.020354465,
-0.022362772,
-0.0016571926,
-0.010774297,
-0.026542222,
0.0032193977,
-0.037913583,
-0.00645915,
-0.010407916,
0.02769564,
-0.010034751,
0.019255323,
-0.013305035,
0.0041760574,
0.010597891,
-0.014967316,
0.021263631,
0.0032465372,
0.009627662,
-0.026800046,
0.011357791,
-0.046923827,
-0.0053362623,
0.018332588,
-0.0016775471,
-0.021222921,
0.0021694468,
0.00816214,
0.017233446,
0.011635968,
-0.02931043,
0.0038096772,
0.0056314017,
-0.0049664895,
-0.0070969234,
-0.0058892253,
0.012640122,
0.0010279005,
0.021521455,
-0.0031871698,
-0.009810852,
0.02053087,
0.0055703386,
-0.020042364,
0.0013247364,
-0.041007463,
-0.020775123,
-0.009050952,
0.007436164,
-0.0070155053,
0.002478156,
-0.004393172,
-0.0045288685,
-0.011717387,
0.007334392,
0.017830512,
-0.008236773,
-0.033299904,
-0.007565076,
-0.0006750897,
0.008623508,
-0.002435751,
-0.017450562,
0.0006106339,
-0.006856062,
-0.032811396,
-0.007938242,
-0.039894752,
0.04602823,
0.020571578,
0.0039114496,
-0.025999436,
-0.004905426,
-0.025605917,
-0.0034178537,
-0.03796786,
0.016799219,
0.007266544,
0.0047968687,
-0.00025739917,
0.02352976,
0.018522562,
0.015455823,
-0.038890596,
-0.0155779505,
0.0036807656,
-0.002188105,
0.009593737,
0.0020541048,
-0.017192738,
-0.008793129,
0.019201044,
0.0048375777,
-0.0072394046,
0.025225967,
-0.009471611,
-0.016052887,
-0.010733588,
0.018875374,
0.00512254,
0.0070494297,
0.008352115,
-0.03916199,
-0.00294122,
0.00059706427,
0.0027037514,
-0.00113985,
0.0065371757,
0.01598504,
0.0013221921,
-0.024805307,
-0.024995282,
-0.0078364685,
-0.00070095685,
-0.001552876,
0.010692879,
0.028170578,
-0.0034008918,
-0.01025865,
0.023000546,
-0.0018115473,
-0.033191346,
0.00082053937,
-0.0024730675,
0.009335915,
0.015198,
-0.028821921,
0.001982864,
-0.012253388,
0.019119628,
-0.01865826,
-0.028224858,
-0.011730957,
-0.036285225,
-0.015713647,
0.020802263,
0.022986975,
-0.0045967167,
-0.008148571,
0.0081689255,
-0.013698555,
0.0031193218,
-0.00968194,
0.02209138,
-0.049583476,
-0.00042723172,
0.0035484617,
-0.021331478,
0.0133660985,
0.0009100142,
-0.037886444,
-0.016826358,
0.0205173,
0.16902347,
-0.0189975,
0.02247133,
-0.012904731,
-0.0114256395,
0.020815833,
0.024615332,
0.007347962,
0.00055550726,
-0.007850039,
0.031698685,
-0.0068424926,
-0.0035077527,
0.012266957,
-0.0027444602,
-0.0057738833,
-0.028957618,
-0.0089423945,
0.014302404,
0.01176488,
0.012864022,
-0.023299078,
0.014166707,
0.010312929,
0.048606463,
0.027044298,
-0.030585974,
0.0055194525,
0.025999436,
0.0072122654,
-0.0024442319,
0.0009201914,
-0.0069035557,
0.012463717,
-0.021575732,
-0.016554965,
0.0005648364,
0.0014417745,
-0.012484072,
0.009844776,
0.01331182,
0.005692465,
-0.038537785,
-0.012070198,
-0.007307253,
0.004304969,
0.0050750463,
-0.025795892,
-0.03954194,
0.019133197,
-0.029093314,
-0.031318735,
0.01861755,
0.0014095467,
-0.008460673,
-0.018956792,
0.020083072,
0.03650234,
0.005533022,
0.026515082,
0.0016724585,
0.003295727,
-0.026162272,
0.016948484,
-0.03302851,
0.014248125,
0.009871915,
-0.030341722,
-0.00068357075,
0.009837992,
0.01083536,
-0.005583908,
-0.0019251931,
0.0100686755,
-0.006425226,
-0.012321236,
0.048063677,
0.030504558,
-0.00194894,
0.011445994,
0.009919409,
0.0011364575,
-0.021792846,
0.022009961,
-0.03335418,
-0.04372139,
0.024561053,
-0.015469393,
-0.006143656,
-0.012660477,
0.008711711,
0.0024832448,
-0.014003872,
0.0034551704,
-0.008603154,
0.018970361,
0.008677787,
-0.011710602,
0.0011390019,
-0.014953746,
-0.017830512,
0.060249213,
-0.0013026857,
0.023801154,
-0.03229575,
-0.016989194,
-0.009634446,
0.017369144,
0.019662412,
0.008033229,
0.014804481,
-0.022878418,
-0.008501382,
-0.038592063,
0.020842971,
0.025741613,
-0.0073411767,
-0.011167816,
-0.004393172,
-0.0019930413,
0.0006996847,
-0.038917735,
-0.012049843,
-0.0022610417,
-0.017572688,
-0.009220572,
-0.0013425465,
-0.012395869,
0.0034704362,
-0.013583213,
0.007938242,
-0.022905556,
0.0021948898,
-0.005468566,
-0.014085289,
-0.00797895,
-0.020259477,
-0.0025493966,
0.0025256497,
0.017572688,
-0.0038537786,
-0.013990302,
0.0023560293,
0.008331761,
0.011188171,
0.019106057,
0.021168644,
0.019526716,
-0.013786757,
-0.0016817877,
-0.037099402,
-0.018006917,
0.003063347,
-0.0065371757,
0.009505535,
0.01273511,
-0.020951528,
-0.017301295,
-0.004020007,
-0.00796538,
-0.023638317,
0.010686094,
0.03153585,
0.01902464,
0.018753247,
0.011805589,
-0.17206307,
0.017423421,
0.024072547,
-0.008616723,
0.024045408,
-0.009600522,
0.010414701,
-0.010543613,
-0.007103708,
0.0066525177,
0.011520627,
0.014275264,
-0.012300882,
-0.018305449,
-0.00034157335,
0.03036886,
-0.032485727,
0.054468546,
0.014343113,
0.008698141,
-0.015279418,
-0.021263631,
0.009953333,
-0.007904317,
-0.015686506,
0.0053735785,
-0.014112429,
-0.00027393716,
0.0075447215,
-0.010828575,
-0.0125112105,
-0.013121845,
0.043097187,
0.022932697,
0.00010087121,
-0.004997021,
-0.029717518,
0.0020676744,
-0.006316669,
0.004980059,
0.014587366,
0.04247298,
0.00778219,
-0.019865958,
0.0028275743,
0.0010932044,
0.037913583,
-0.012497641,
0.012090552,
-0.009193433,
-0.011561336,
0.0011356095,
0.021955682,
-0.008392824,
0.0037791457,
0.0049902364,
-0.0057365666,
0.008243558,
0.024913864,
-0.008121432,
-0.018970361,
0.002213548,
0.011256019,
0.019920235,
-0.00852852,
-0.029798936,
-0.0034806135,
0.003969121,
-0.012246603,
0.003436512,
-0.015523671,
-0.0077754054,
0.014573797,
-0.036800873,
0.041984476,
-0.005716212,
-0.009817637,
0.009166294,
-0.010957487,
-0.010041536,
-0.005170034,
0.022484899,
-0.013698555,
-0.0055431994,
0.0053362623,
0.012836882,
0.031047342,
0.028007744,
0.0026308144,
-0.022118518,
-0.00399626,
-0.023027685,
0.031101622,
-0.006649125,
0.017423421,
0.03769647,
-0.006499859,
0.008894901,
0.025035992,
-0.023271937,
0.0015350658,
0.009240927,
-0.028387694,
0.011649539,
0.036176667,
-0.01599861,
-0.005054692,
0.0007963684,
0.0167178,
-0.02359761,
0.0015350658,
0.011317083,
0.008067152,
0.020435883,
-0.01593076,
0.026908603,
0.008277482,
-0.0006326846,
-0.0055058827,
-0.0075040124,
0.06410299,
-0.0037927153,
-0.00232889,
0.006510036,
0.012043058,
-0.0060825925,
-0.12451504,
-0.028034883,
-0.017531978,
0.018739676,
0.0039250194,
0.00054617814,
0.018006917,
0.02656936,
-0.014940177,
0.020558009,
-0.01253835,
-0.015143721,
-0.0030582582,
-0.012687616,
0.026080854,
-0.015754355,
-0.0029310428,
-0.0065846695,
-0.027953465,
0.050071985,
-0.0040098294,
-0.001865826,
0.025809461,
-0.008141786,
-0.0106318155,
-0.015116583,
-0.02321766,
0.016161446,
-0.0040098294,
0.0070494297,
0.008643863,
-0.015279418,
0.018522562,
0.009159509,
-0.023407634,
0.0014680658,
0.007375101,
-0.021426467,
0.054875635,
-0.025361663,
0.0034008918,
-0.021060087,
0.0066593024,
0.009437687,
0.00834533,
0.0015011418,
-0.01101855,
-0.0007607481,
0.02012378,
-0.013386453,
0.007137632,
-0.012904731,
-0.0063370233,
-0.010217941,
-0.001923497,
-0.023000546,
0.0010635208,
0.020218767,
-0.008725281,
-0.007381886,
0.0018285094,
0.018414006,
-0.0043219314,
0.005278591,
0.0006462542,
-0.013963163,
-0.020761553,
-0.032187194,
0.0042676525,
0.011445994,
0.0025154725,
-0.013203262,
-0.00816214,
-0.004121779,
-0.025565207,
0.0008103621,
-0.019323172,
-0.0062250737,
0.005906187,
-0.0022763077,
-0.02587731,
-0.007266544,
0.022986975,
-0.004366033,
0.023869002,
0.009783712,
0.017803371,
-0.00931556,
0.007029075,
-0.0060317065,
0.010781081,
0.021317909,
0.010808221,
-0.00019845602,
-0.016012179,
-0.00023089595,
-0.012348375,
-0.00930199,
0.0056449715,
0.023991128,
-0.020137351,
-0.00569925,
-0.051428948,
0.035118237,
0.0174777,
-0.009356269,
-0.0062352507,
-0.01518443,
0.01446524,
-0.002783473,
0.019580996,
-0.0046950965,
-0.03237717,
0.03457545,
-0.009668371,
0.000029524575,
-0.021168644,
0.007117278,
0.0448341,
0.0044406657,
0.020286616,
0.015835773,
0.0051191477,
0.025158118,
0.021019377,
0.031155901,
-0.009932979,
-0.009926194,
-0.02320409,
0.021982823,
0.010129739,
-0.022688443,
0.004457628,
-0.012314451,
-0.019106057,
0.01083536,
-0.00009731978,
-0.005845124,
0.004433881,
0.0062725674,
0.03150871,
0.039759055,
-0.0031668155,
-0.040898904,
0.027777059,
-0.026542222,
-0.011615614,
-0.0023594217,
-0.008508166,
0.0016885725,
-0.00086421665,
-0.0152658485,
0.021114364,
-0.0023967382,
0.007917887,
-0.003731652,
-0.044372734,
-0.0030294228,
0.015686506,
-0.0018810917,
-0.008494597,
-0.016622813,
0.02509027,
-0.013936023,
-0.003558639,
0.012667262,
-0.016052887,
0.008562445,
-0.013040427,
0.021141503,
-0.025253106,
-0.026040144,
-0.0072733285,
0.0040403614,
-0.0033330435,
0.0075582913,
0.008229989,
-0.0061470484,
-0.040030446,
-0.00041345006,
0.0025171689,
0.0071715564,
0.014424531,
0.008840622,
-0.04334144,
0.058729414,
0.0350911,
-0.006096162,
-0.011052474,
0.012389084,
-0.01518443,
-0.0022695228,
-0.026786475,
0.024832446,
0.0077007725,
0.024859587,
-0.0012585844,
0.01673137,
-0.005010591,
-0.006102947,
0.011086399,
0.0022271178,
-0.021819986,
-0.00039330762,
0.010326498,
-0.024859587,
-0.0069544422,
0.013108275,
-0.039704777,
-0.017260587,
-0.0040267915,
-0.00051734265,
0.026162272,
0.014777341,
-0.0247646,
-0.0013645972,
0.0050920085,
0.005444819,
-0.002742764,
0.016772078,
-0.015510102,
-0.0001783136,
0.021507883,
0.024927434,
-0.002768207,
-0.001512167,
-0.011887007,
-0.00096344465,
0.015835773,
-0.01593076,
0.017301295,
0.0027800805,
0.022308493,
-0.025633056,
-0.019580996,
0.006292922,
-0.02282414,
-0.03650234,
0.0025205612,
0.007029075,
-0.018793955,
0.08847407,
0.0063913018,
-0.016880635,
0.0018268132,
0.009369838,
-0.00072894426,
-0.021860695,
-0.026325107,
-0.0001751332,
-0.027139286,
0.005872263,
-0.018902512,
0.0066694794,
-0.038646344,
-0.041143157,
-0.0042235516,
-0.011310297,
0.023285508,
-0.017559119,
-0.024031838,
0.014153138,
0.0025663588,
0.0040844628,
0.014261695,
-0.012959009,
0.0029581822,
0.026284399,
0.006730543,
0.0034416006,
-0.027288552,
-0.0044508427,
0.0059740352,
-0.027682072,
0.0067237583,
0.017247016,
-0.020408744,
0.0030786127,
-0.019336741,
-0.0013416985,
0.01937745,
-0.004664565,
0.023801154,
-0.000982951,
0.017287726,
0.008481027,
-0.010156877,
-0.010448625,
-0.011866652,
-0.033924107
] |
The switch from the latent to the lytic form of Epstein-Barr virus (EBV) infection is mediated by expression of the viral immediate-early (IE) proteins, BZLF1 (Z) and BRLF1 (R). An EBV early protein, BRRF1 (Na), is encoded by the opposite strand of the BRLF1 intron, but the function of this nuclear protein in the viral life cycle is unknown. Here we demonstrate that Na enhances the R-mediated induction of lytic EBV infection in 293 cells latently infected with a recombinant EBV (R-KO) defective for | [
-0.030223174,
-0.013041692,
-0.022795904,
-0.025095787,
-0.023999961,
-0.008198408,
-0.0060304296,
-0.006561432,
-0.015233345,
0.004880488,
-0.014408093,
-0.00001869448,
0.00054241734,
0.0072716903,
-0.010268304,
0.0020580576,
0.01392106,
-0.0076640234,
0.0013900766,
0.012865819,
-0.03144076,
0.00637203,
0.0021257012,
-0.047621116,
-0.013481376,
0.0045524165,
-0.0042006695,
-0.023999961,
-0.014259278,
0.010937975,
-0.0011609339,
0.0047215256,
-0.008834259,
0.01327168,
-0.0033314489,
-0.023878202,
-0.0025450916,
-0.017289711,
0.033848874,
0.013853416,
0.005425019,
0.015530977,
-0.016437402,
0.015273931,
0.018940216,
0.0022965013,
0.017925562,
-0.006700102,
-0.0027514047,
0.016099185,
0.0059932256,
-0.020441905,
-0.013190508,
0.0100450795,
-0.02410819,
-0.017560286,
0.013346088,
0.005245764,
-0.0032384389,
-0.024473466,
-0.01009243,
-0.014556909,
-0.031548988,
0.008401339,
0.01013978,
0.043210752,
0.005259292,
0.018344952,
0.00014141746,
0.012202911,
0.03111607,
0.022850018,
-0.012974048,
0.018886102,
0.01353549,
-0.010133016,
-0.01626153,
-0.000115416944,
0.013197272,
0.0009030425,
0.020090159,
0.00073773833,
-0.014786898,
0.012750824,
0.010281832,
-0.019454308,
0.0135084335,
0.037474573,
0.01077563,
-0.007434035,
0.010160074,
0.03290186,
0.0299526,
0.01837201,
-0.024067603,
0.006689955,
0.002702363,
0.011431773,
0.014705725,
-0.023350582,
-0.002590751,
-0.00510033,
-0.009111597,
-0.00722434,
-0.00700788,
0.003669667,
-0.012196147,
-0.020347204,
0.02570458,
-0.0076031443,
-0.041452017,
0.032766573,
-0.004062,
-0.04272372,
0.039449766,
0.0031369734,
0.02271473,
-0.026570419,
-0.018656114,
-0.0041600834,
-0.016193885,
0.016559161,
-0.00078255223,
-0.026908636,
0.03982857,
0.018250251,
-0.01795262,
-0.017127367,
-0.016680919,
-0.010099194,
0.025136374,
0.01635623,
-0.0059154355,
-0.0012268864,
-0.012615537,
0.0065512857,
-0.01030889,
-0.027043924,
-0.00972039,
0.0041127326,
0.020861296,
0.019806055,
-0.0099842,
-0.017073253,
-0.005134152,
0.018466711,
0.0035309976,
0.022552386,
-0.0010535496,
-0.009788034,
-0.0006603709,
-0.01774969,
0.036175814,
-0.026813935,
-0.023093536,
0.02209241,
-0.030006714,
0.047215253,
-0.02326941,
-0.022904133,
-0.00472829,
-0.005418255,
0.019291963,
0.014435151,
0.008705735,
0.03836747,
0.015679793,
-0.0031572664,
0.0033838726,
-0.026989808,
-0.01162794,
0.009341585,
-0.051544446,
0.013609898,
0.0073460983,
0.008766615,
0.013664014,
0.005719269,
-0.00094362866,
-0.026624532,
-0.005293114,
0.0124396635,
0.047945805,
0.006280711,
-0.01666739,
0.007995477,
0.02271473,
-0.026367487,
-0.007873719,
-0.010383298,
0.0029509533,
0.022768846,
0.015125116,
-0.002572149,
-0.61950743,
-0.033280667,
0.010870332,
0.0028021375,
-0.00796842,
0.009321292,
0.012263791,
0.0036290807,
-0.005425019,
0.030358462,
-0.030006714,
0.0005931501,
0.015503921,
-0.021700077,
-0.0058748494,
-0.017993206,
-0.0060642515,
0.0038049542,
0.02824798,
0.0008282117,
-0.020698952,
0.00066924916,
-0.011614411,
0.035742894,
-0.00017312542,
0.012656123,
0.035742894,
-0.0211454,
0.0018872573,
0.020198388,
-0.011134142,
0.037555743,
0.008347224,
-0.018710228,
0.047188196,
-0.010768866,
-0.0028444147,
0.008962781,
0.03506646,
0.021064227,
-0.015774494,
-0.0076775523,
0.004454333,
-0.0016251382,
-0.021794777,
0.016342701,
0.0027091275,
0.017384414,
0.004653882,
-0.019508423,
0.0001732311,
-0.004471244,
-0.026259258,
-0.0059729326,
0.014042818,
0.0101194875,
-0.002348925,
-0.028707957,
0.013136393,
-0.005218706,
-0.01561215,
0.0077654887,
0.0074272705,
-0.018304367,
-0.017925562,
-0.023337053,
-0.0004071301,
0.019170204,
0.0013477993,
0.013501668,
0.028545612,
0.027111568,
0.0073258053,
0.019521952,
0.00993685,
0.024608754,
0.0044306577,
0.013319031,
-0.021294216,
0.008901902,
-0.0095648095,
-0.009632453,
-0.045510635,
-0.021321272,
0.026408074,
-0.028302096,
-0.01772263,
0.020983055,
0.0058545563,
-0.010924446,
0.00017301973,
0.018317895,
-0.012047331,
-0.014678668,
-0.03506646,
0.01975194,
0.0074678566,
0.0002213215,
0.004731672,
-0.0026533215,
-0.00094362866,
-0.022146525,
0.015043943,
0.000106380176,
-0.012006745,
0.00056271045,
-0.018466711,
0.0122908475,
0.035174686,
-0.03365947,
-0.01837201,
-0.010904153,
0.0063415905,
-0.011310015,
-0.0072784545,
-0.028843245,
0.02475757,
0.012446428,
0.0034143124,
-0.029194992,
0.0024453173,
-0.00026127353,
0.00361217,
-0.0009867515,
0.004850048,
0.024798155,
-0.0015777877,
-0.001724067,
-0.006700102,
-0.0059019066,
0.016829735,
-0.006838771,
0.025609879,
-0.011857929,
0.033551242,
0.016423874,
0.02962791,
0.023445282,
-0.0091589475,
-0.0397474,
-0.03071021,
-0.008211937,
0.007819604,
-0.007434035,
-0.0055467775,
-0.00682186,
0.0017468968,
-0.00013243355,
-0.00072420965,
0.013988703,
0.023391167,
-0.002624573,
-0.01697855,
0.006334826,
0.01592331,
-0.021050697,
-0.02719274,
-0.018723758,
-0.022444157,
0.0038015721,
0.0029729377,
0.004751965,
-0.012757589,
-0.010904153,
0.019508423,
-0.011235607,
0.038800385,
0.010904153,
0.005184884,
-0.03655462,
0.022674145,
0.009862442,
-0.019995457,
0.001733368,
-0.008685443,
0.0037339283,
-0.00286809,
-0.002419951,
-0.0057497085,
-0.007954891,
0.0059966077,
-0.0044238935,
-0.017113838,
-0.016965022,
0.038692158,
0.023066478,
0.01676209,
-0.008130765,
0.036148757,
0.01826378,
-0.013285209,
0.027977405,
-0.015598621,
0.020942468,
0.026245728,
-0.022904133,
0.010532114,
0.007934598,
-0.0037170176,
0.017127367,
0.007170225,
-0.0072919833,
0.00945658,
-0.021077756,
0.0015583402,
-0.029492622,
0.015733909,
-0.021470089,
0.020036044,
0.01933255,
0.009314528,
0.0031707953,
-0.01289964,
0.0015025341,
-0.024189362,
0.0036561382,
-0.0073866844,
0.034768827,
0.0032164548,
-0.031197242,
-0.03725811,
0.006574961,
0.030818438,
0.0019650476,
-0.016491517,
0.0060743983,
-0.0076775523,
0.028626785,
0.011546768,
-0.005533249,
-0.0018466711,
0.008042828,
0.026462188,
0.0012361874,
-0.005604275,
-0.006689955,
0.033470068,
-0.005381051,
0.026895108,
-0.012608773,
-0.030006714,
0.004718143,
0.0072175753,
0.023107065,
0.028383268,
0.015585093,
0.008651621,
0.019616652,
-0.022917662,
0.025515178,
-0.021226572,
0.02719274,
-0.02784212,
-0.0017857918,
-0.0025569294,
-0.009152183,
0.0010772248,
0.020008987,
0.038935672,
0.013961646,
0.0016640333,
-0.0061995387,
0.025515178,
-0.008414867,
0.005272821,
-0.005171356,
-0.015449805,
-0.023215294,
0.00506989,
0.0029408068,
-0.020861296,
-0.00748815,
0.0061555705,
-0.0199684,
0.016532103,
0.014583967,
0.00042192714,
0.015503921,
0.011418245,
0.0024148775,
-0.01289964,
-0.014570438,
0.014827484,
0.0032130724,
-0.01099209,
-0.030926667,
-0.020942468,
-0.002737876,
-0.0042886063,
0.019589595,
0.022227697,
0.0064904066,
0.000012551064,
0.029113818,
-0.0011338764,
-0.01316345,
0.016545633,
-0.019630183,
0.009909792,
0.0018179226,
0.0059086713,
0.010904153,
-0.02463581,
-0.012412607,
0.033821814,
0.0041397903,
0.009361879,
-0.011492653,
0.004995482,
-0.012114975,
0.0042886063,
0.0019041682,
-0.014827484,
-0.028626785,
-0.0036290807,
0.0149763,
-0.0003826093,
0.001703774,
0.008096943,
0.010112722,
-0.026949223,
-0.039152134,
-0.0023962755,
-0.0123652555,
0.016410345,
0.029546738,
-0.01772263,
0.024297593,
0.017235598,
0.021253629,
-0.0024639193,
-0.032766573,
0.017857919,
-0.007102581,
0.002068204,
0.00722434,
0.0019160059,
0.006632458,
0.009287471,
0.005107094,
0.014164576,
-0.04448245,
0.024094662,
0.0054858983,
0.00018908508,
0.0022034913,
0.003669667,
0.02761213,
0.0072716903,
0.0031268268,
0.0031893973,
0.015409219,
0.015165702,
-0.015300989,
0.003487029,
0.0020884972,
-0.0027632422,
0.0026516304,
0.005120623,
-0.035607606,
0.008205173,
0.0046268245,
-0.0017773364,
0.0075557935,
0.018710228,
0.0086042695,
0.008665149,
0.00020779278,
-0.00038514592,
0.00091488013,
-0.011073262,
-0.018209666,
0.008861315,
-0.021091284,
0.03439002,
-0.009463344,
-0.01342726,
-0.027788004,
-0.012162325,
0.0077384314,
-0.02570458,
-0.0046809395,
-0.008421632,
-0.0035343796,
-0.014881599,
-0.023851145,
0.029194992,
0.0034193855,
0.0028393413,
-0.012906405,
0.00033462458,
-0.01762793,
-0.0062908577,
-0.009591867,
0.02347234,
-0.036798134,
-0.037745144,
0.010011258,
0.006517464,
0.014543381,
-0.00517812,
-0.0030219792,
0.003370344,
-0.0019058593,
-0.019251378,
-0.007961655,
-0.005475752,
-0.035526436,
0.0024098044,
0.0024182599,
0.012297612,
-0.024554638,
-0.018967275,
-0.018304367,
-0.0060845446,
0.014611024,
0.028545612,
-0.0028833097,
0.0015405837,
0.022850018,
0.021794777,
0.015476863,
-0.0038759802,
-0.011452067,
0.016518574,
-0.023661742,
-0.004904163,
-0.009409229,
-0.005191649,
-0.0061420416,
-0.0041499366,
-0.0016995462,
-0.035742894,
-0.01676209,
0.022335926,
-0.009300999,
0.0054317834,
-0.003334831,
0.016315645,
0.038935672,
-0.019981928,
-0.00443404,
0.0065681967,
-0.0009114979,
0.021429501,
-0.016992081,
0.026151028,
-0.0008117236,
-0.008638091,
0.02060425,
0.00992332,
-0.015260403,
0.009294235,
0.008881609,
-0.01364372,
0.030926667,
0.018777872,
-0.018574942,
-0.03731223,
-0.011688819,
0.0020851148,
0.0042209625,
0.013420496,
-0.014692197,
-0.009483637,
0.0032654963,
0.016315645,
-0.0034515162,
-0.0017756453,
-0.026638063,
0.01635623,
0.030656094,
-0.016193885,
-0.020090159,
-0.028302096,
0.004471244,
-0.01613977,
-0.0011812269,
-0.023107065,
-0.034687653,
0.00013021399,
-0.008624563,
0.03663579,
0.019427251,
0.028978532,
-0.011594119,
0.011688819,
0.034768827,
0.008299873,
0.012514072,
-0.0075287363,
0.005624568,
-0.012886112,
0.017357355,
0.0299526,
-0.01013978,
0.010674165,
-0.028410325,
0.018344952,
-0.0073258053,
0.002479139,
-0.008983074,
0.0031893973,
-0.022430629,
-0.02040132,
0.018453183,
-0.01848024,
0.021253629,
-0.031684276,
0.003461663,
0.009145419,
-0.0066256938,
0.017370885,
-0.0025264896,
0.0005250837,
-0.007806075,
0.025041671,
-0.0021341566,
0.0039774454,
-0.0055941283,
0.009064247,
-0.0076302015,
-0.009443051,
0.013555784,
0.009470108,
0.0076504946,
-0.010904153,
-0.022227697,
0.023810558,
-0.0044610975,
-0.0137654785,
-0.030845495,
-0.02506873,
0.0136572495,
-0.022011237,
-0.03544526,
-0.02176772,
-0.033091266,
-0.006896268,
-0.0058782315,
0.010525349,
0.014367507,
0.008455453,
-0.024473466,
0.019954871,
0.002458846,
0.030196117,
-0.024378765,
0.0412085,
0.024297593,
-0.007034938,
-0.026435131,
-0.025609879,
-0.0023556894,
0.00083708996,
0.01688385,
0.026462188,
-0.0011220387,
-0.009138655,
0.017817331,
0.007826368,
0.0031758684,
-0.022998834,
0.023120593,
-0.027016867,
0.00696053,
-0.0060642515,
-0.0044272756,
-0.016640333,
0.012392313,
-0.021618905,
0.0187914,
-0.0063043865,
-0.007095817,
-0.01697855,
0.01773616,
-0.0059999903,
0.025893982,
-0.014353978,
-0.009483637,
-0.005157827,
-0.0035614371,
-0.0011710804,
-0.011012383,
-0.0153145185,
0.030629037,
0.020428376,
-0.009219827,
0.007880483,
0.0136166625,
0.002516343,
-0.011587354,
-0.005303261,
0.037285168,
-0.0101194875,
-0.00066544424,
-0.015990954,
0.0033601974,
0.0092333555,
0.0038827443,
0.00069165614,
-0.0077925464,
-0.012081153,
0.018033791,
0.041452017,
0.010105958,
-0.029032646,
0.005702358,
-0.01337991,
0.0092333555,
-0.02198418,
-0.032360714,
0.0015109896,
-0.05936405,
-0.0112559,
-0.01162794,
0.010234482,
0.022552386,
0.018047322,
0.020901881,
0.003314538,
0.037907492,
-0.0213348,
-0.0045591807,
0.001127112,
-0.006916561,
-0.003279025,
0.00823223,
-0.022565916,
-0.01381283,
0.023120593,
-0.0035986411,
0.003967299,
-0.027016867,
-0.009673039,
0.01891316,
0.031386644,
-0.019684296,
0.035418205,
-0.025826339,
0.0044306577,
-0.002813975,
-0.008915431,
0.017059723,
0.0027142006,
0.01375195,
0.012520836,
-0.020955997,
-0.01173617,
0.0042378735,
0.0091589475,
-0.022877077,
-0.008286345,
-0.028978532,
-0.008685443,
0.0119255725,
0.0105591705,
0.0008510414,
0.024473466,
0.0001268318,
-0.0065106996,
-0.005036068,
-0.00043228507,
-0.0002105408,
-0.019981928,
0.0023962755,
-0.00072801457,
0.027652716,
-0.016085656,
-0.011810578,
0.01475984,
-0.04515889,
-0.02040132,
0.0056178034,
-0.019589595,
0.025231075,
0.007285219,
-0.008983074,
-0.017830862,
-0.027138624,
-0.048054036,
0.017668517,
-0.01030889,
0.023323525,
0.0013012943,
0.0064193807,
0.00737992,
0.0029594088,
-0.016653862,
0.028762072,
-0.0023523073,
-0.014083404,
0.024473466,
0.0074205063,
0.016491517,
0.023945846,
-0.022362985,
-0.003950388,
0.023742914,
0.0005098639,
0.0049819537,
0.038719214,
-0.034768827,
-0.026151028,
0.0055839815,
0.00029467256,
-0.0035614371,
0.035228804,
0.016870322,
-0.020036044,
-0.01327168,
0.025474591,
0.008529861,
-0.01722207,
0.007907541,
0.005479134,
0.018534355,
-0.0029915397,
-0.023120593,
-0.0030997694,
-0.000015127335,
-0.01795262,
0.026151028,
0.015558035,
0.020225445,
0.012169089,
0.0033111558,
-0.011431773,
0.006561432,
-0.008252523,
-0.040856753,
-0.0076234373,
0.011242371,
0.014597496,
-0.027544487,
0.0061014555,
-0.001610764,
-0.020414848,
-0.016248,
-0.0009258722,
-0.018142022,
-0.034362964,
-0.0009613851,
0.011715877,
-0.019806055,
-0.012689945,
0.005773384,
-0.0113708945,
-0.019914284,
-0.005015775,
0.0086042695,
0.0015651045,
0.0019988692,
-0.009781269,
-0.0076978453,
-0.018412596,
0.009294235,
0.008908666,
0.002611044,
0.0018635821,
0.18712933,
-0.017966148,
0.0026769966,
0.00065107,
-0.04123556,
-0.008184879,
-0.012060859,
-0.005313407,
0.010931211,
-0.0019176969,
0.012196147,
0.018399067,
-0.017573815,
0.0001857029,
0.005326936,
-0.0076031443,
-0.023512926,
-0.0015076074,
-0.022877077,
0.0019582831,
0.018250251,
-0.0039774454,
0.006693337,
-0.006794803,
0.037149884,
0.012649359,
-0.04981277,
0.015760966,
0.016897378,
-0.000054749064,
-0.015788024,
-0.0056583895,
-0.01342726,
0.0146516105,
-0.02061778,
0.032739516,
-0.0005090183,
-0.025393419,
0.009145419,
0.018926688,
0.011201785,
0.020144273,
-0.02654336,
-0.02857267,
-0.0000108203385,
-0.008455453,
-0.0094159935,
-0.03195485,
-0.021903008,
0.008543391,
-0.037339285,
0.0004895708,
0.0039639166,
0.0083134025,
0.021862421,
-0.0019075504,
0.010133016,
0.011059734,
-0.0010222644,
0.008367517,
-0.011201785,
0.022877077,
-0.04559181,
0.0112559,
-0.012196147,
0.026908636,
0.005228853,
0.01354902,
0.026056327,
-0.030033773,
-0.0041939053,
-0.017560286,
-0.01795262,
0.010065372,
-0.027449785,
-0.015517449,
0.028112693,
0.0086786775,
0.03252306,
0.033930045,
0.021280685,
0.007095817,
-0.034471195,
0.013183744,
-0.0066054007,
-0.025731638,
0.032793634,
0.0004553262,
-0.014678668,
-0.012148797,
0.034849998,
-0.01793909,
-0.01327168,
0.004951514,
0.016505046,
0.0042344914,
-0.014786898,
0.0025214164,
-0.0013985321,
-0.0036358451,
-0.012324669,
0.08382399,
0.031792507,
-0.004731672,
-0.012737296,
-0.004951514,
0.00976774,
0.0073663914,
0.02527166,
-0.026773348,
0.022024766,
0.0021493763,
0.011093555,
-0.009077775,
0.00035386076,
-0.017641459,
0.018358482,
-0.022552386,
0.031630162,
-0.005289732,
-0.008069885,
-0.019724883,
0.01858847,
0.029384393,
-0.023228822,
-0.006649369,
-0.02728744,
0.013359617,
-0.015098059,
-0.03049375,
0.006405852,
0.010626814,
0.0041228794,
-0.011668527,
0.00700788,
0.0005060589,
0.018169079,
-0.017912034,
-0.011330308,
-0.0060642515,
-0.010789159,
-0.01444868,
0.0046674106,
0.0062840935,
-0.0041127326,
-0.014272806,
0.030087886,
0.01635623,
-0.015206289,
0.017682046,
-0.030980783,
-0.038962733,
-0.0064734956,
-0.024730511,
0.010721516,
-0.032739516,
-0.040937927,
-0.028924417,
0.0023810558,
0.01953548,
-0.03725811,
-0.0014526469,
0.00469785,
-0.045267116,
-0.0029898484,
-0.008915431,
-0.17121956,
-0.004041707,
-0.0026583946,
-0.0072784545,
0.0299526,
0.01635623,
0.018087907,
-0.009578338,
-0.026394544,
0.037636917,
0.020022515,
0.020577192,
-0.07018703,
-0.0249605,
-0.022065353,
0.0054689874,
-0.011512946,
0.018994331,
0.039368592,
-0.0126223015,
0.03187368,
-0.03165722,
0.019521952,
0.0019058593,
-0.015016886,
0.009226591,
-0.0014501103,
-0.0060473406,
-0.013650484,
-0.017709102,
-0.0034515162,
0.015517449,
0.01582861,
-0.037718087,
0.04778346,
-0.0108906245,
-0.0007352017,
-0.0031555754,
-0.0019853406,
0.016112713,
0.034768827,
0.01773616,
-0.0057970593,
0.01731677,
-0.02083424,
0.024365235,
0.0012750825,
-0.0068523,
0.0073122764,
0.0022474597,
0.0053201714,
-0.046078842,
0.009246884,
0.018439654,
0.0115197105,
0.005350611,
0.00006764363,
0.02176772,
-0.0072716903,
-0.0036595205,
-0.021483617,
-0.01088386,
0.060392234,
-0.012432899,
0.007156696,
-0.025028143,
-0.004917692,
0.0224171,
-0.019237848,
0.0042852242,
-0.0057125045,
-0.0017739543,
0.02951968,
-0.024365235,
0.015260403,
0.019521952,
-0.014164576,
0.012717003,
0.0075152074,
-0.0023353964,
-0.017763218,
0.037095767,
-0.021064227,
-0.0041871406,
-0.016491517,
-0.0027700067,
0.0075760866,
0.03165722,
0.0059492574,
-0.020130744,
-0.008144293,
-0.023431754,
0.015003357,
-0.015341575,
0.016735034,
0.016058598,
0.012487014,
-0.002497741,
-0.014624553,
0.017249126,
0.005644861,
-0.030764323,
-0.0154227475,
0.0150574725,
0.039990913,
-0.027260384,
-0.011763227,
0.013833122,
0.061528645,
-0.01793909,
-0.005259292,
0.010653872,
-0.0036020232,
0.03793455,
0.00014902737,
0.02061778,
-0.020969525,
0.0044949194,
0.01072828,
-0.036581676,
0.07603144,
0.0043731607,
-0.02494697,
0.0039977385,
-0.011533239,
-0.015192759,
-0.1248972,
-0.025352834,
0.0061048376,
-0.004880488,
-0.008347224,
0.00993685,
0.006054105,
0.0199684,
0.0043866895,
0.022376513,
-0.032117195,
0.0003077785,
-0.010288596,
-0.010329182,
0.014489266,
0.018250251,
0.022904133,
0.00039423554,
-0.038692158,
0.030818438,
0.0060743983,
0.0042886063,
-0.0063415905,
-0.009043953,
0.023567041,
-0.0040484713,
-0.039639167,
0.015896253,
0.026489247,
0.0004739282,
0.0059458753,
-0.026083384,
0.019562539,
0.002348925,
-0.030114945,
-0.002272826,
-0.04448245,
-0.006541139,
0.020428376,
-0.03568878,
0.00026994036,
-0.003446443,
0.011999981,
-0.0010983634,
-0.0075422646,
-0.018020263,
-0.014597496,
0.024568167,
0.010166838,
0.0016716432,
-0.022335926,
-0.027760945,
-0.050786838,
-0.020847768,
0.024825213,
-0.031711332,
0.003055801,
0.057091225,
-0.014218691,
-0.015098059,
0.013711364,
-0.0058849957,
0.0004815381,
0.0045050657,
0.030629037,
-0.0032570409,
0.00033948646,
-0.0005369213,
0.018453183,
-0.02719274,
-0.011837635,
-0.0039233305,
-0.0009013514,
0.018710228,
-0.03590524,
0.005536631,
-0.0027328026,
-0.02071248,
0.00165896,
-0.019724883,
-0.03471471,
-0.021835364,
0.02240357,
-0.016816206,
0.04193905,
0.001668261,
-0.0063212975,
0.0014518014,
0.0026347195,
-0.0077654887,
0.0047790227,
0.038151007,
0.0030439633,
-0.02654336,
-0.009673039,
0.021497145,
-0.016586218,
-0.014678668,
0.0076572592,
0.02345881,
-0.01678915,
-0.014435151,
-0.061312187,
0.02325588,
-0.0018940216,
-0.01722207,
0.0015059164,
-0.0061927745,
0.009307764,
-0.007001116,
-0.00040776425,
0.035337035,
-0.03046669,
0.018439654,
-0.01210821,
-0.010363004,
-0.0046809395,
-0.01475984,
0.0397474,
-0.016870322,
0.023418225,
0.013894002,
0.0020174712,
0.0005398807,
0.0042514023,
0.008205173,
-0.023688799,
-0.0122164395,
0.0025636936,
0.020441905,
-0.009571574,
-0.011553532,
0.005174738,
-0.050408036,
-0.009808326,
0.0007237868,
0.0042750775,
-0.014462208,
0.0077519603,
0.026719235,
0.013231094,
0.036419332,
-0.021118341,
-0.036067583,
0.023350582,
0.019697824,
0.008712499,
-0.006747452,
-0.035228804,
0.0010070446,
-0.0030016862,
-0.028653841,
0.017384414,
0.0062164497,
0.00034265727,
-0.018250251,
-0.006804949,
0.005215324,
0.010160074,
-0.007806075,
-0.011972923,
-0.0059661684,
0.018886102,
0.010592992,
0.0084960405,
0.0038658334,
-0.0032654963,
-0.0021967269,
-0.014313392,
0.0020022516,
-0.0117767565,
-0.018777872,
-0.017113838,
0.021930065,
-0.00091488013,
0.027165683,
0.015233345,
0.011783521,
-0.008029299,
0.0087530855,
-0.030412577,
0.006497171,
0.0057226513,
-0.013312266,
-0.00128692,
-0.011709113,
0.016735034,
0.010748573,
0.008949253,
0.0061758636,
-0.0019109326,
0.017546758,
-0.009645982,
0.017330298,
0.014989829,
0.017695574,
0.02252533,
0.0043258104,
0.008502805,
0.012717003,
0.0060980734,
0.010261538,
-0.0017418235,
0.0028900742,
0.021226572,
-0.02314765,
-0.008347224,
0.041830823,
-0.029979657,
-0.04226374,
-0.006967294,
-0.009050718,
-0.012426135,
-0.0026583946,
-0.024094662,
0.006615547,
-0.004843284,
-0.002813975,
0.0016631878,
-0.01486807,
0.0014399638,
0.035851125,
0.020441905,
0.023769971,
0.0027480226,
-0.0086042695,
0.009003367,
0.0019007861,
0.027111568,
0.0020343822,
-0.000337584,
-0.019576067,
0.014042818,
-0.006202921,
-0.022863546,
-0.027057452,
0.0046302066,
0.0020293088,
0.007136403,
0.020996584,
-0.005516338,
0.09886793,
0.023567041,
-0.010437412,
0.0029323513,
-0.026042799,
0.027300969,
0.0046099136,
0.0036290807,
-0.009950378,
-0.03663579,
0.015652737,
-0.027449785,
0.009605396,
-0.040829696,
-0.027706832,
0.02537989,
0.015544507,
0.015558035,
-0.02697628,
-0.028275037,
0.021415973,
0.00361217,
0.017912034,
0.015760966,
-0.011979687,
0.011012383,
0.027558016,
-0.011391187,
0.01688385,
-0.030953726,
-0.0037034887,
-0.014678668,
-0.03985563,
-0.02102364,
0.020252503,
-0.020293089,
-0.009706861,
-0.0062874756,
0.008137529,
0.016058598,
-0.006730541,
-0.0042852242,
-0.0011558605,
-0.016965022,
0.01772263,
-0.008205173,
-0.028762072,
-0.013373146,
-0.024459938
] |
Endometrial polyps are very common benign endometrial lesions, but their pathogenesis is poorly understood, except for a few studies indicating the possibility of benign stromal neoplasm. Although the histopathological diagnosis of endometrial polyp on a surgical specimen is straightforward, it is often difficult to differentiate endometrial polyp from endometrial hyperplasia on a biopsy or curettage specimen. Presently, there is no immunohistochemical marker helpful in this differential diagnosis. In this study, we examined p16 expression in 35 endometrial polyps and 33 cases of endometrial hyper | [
-0.013745003,
0.022213368,
0.0015218602,
-0.02543083,
-0.052097168,
-0.0015033598,
-0.015533914,
0.008384709,
-0.004671757,
0.001631254,
0.008970288,
-0.023899319,
-0.023049908,
0.0030855474,
-0.0281335,
0.017400043,
0.04676905,
-0.0058364784,
-0.023333045,
-0.022213368,
-0.028390897,
0.012168447,
0.009575171,
0.016434804,
-0.0014124664,
0.019716617,
0.04218738,
-0.04924006,
-0.003484513,
-0.016627852,
-0.017181255,
0.00457845,
-0.01052754,
-0.02290834,
0.008506973,
0.0040379167,
0.013950922,
0.0034201636,
0.012824809,
0.00352634,
0.007940699,
-0.0110359,
0.0002708702,
-0.0032158548,
-0.021685703,
-0.0024179236,
0.015508174,
0.000044214987,
-0.01490329,
0.011808091,
0.016048707,
-0.00034869259,
-0.018017795,
0.018970164,
-0.03366754,
-0.007490255,
0.019472089,
-0.0018918685,
-0.008133748,
-0.034491207,
-0.006007004,
-0.0030083284,
-0.026872255,
0.017696049,
-0.024182456,
0.0076318234,
-0.015726961,
0.031402443,
0.012149142,
-0.007863481,
0.025546659,
0.019497829,
-0.011949659,
-0.015057729,
0.009748914,
-0.034388248,
-0.0046781916,
-0.0052444655,
0.0049355887,
0.023436004,
0.011672957,
-0.018043535,
-0.016962467,
0.02105508,
0.024684379,
0.0003018383,
-0.0150963385,
0.013062902,
0.005331337,
-0.006492841,
0.021325348,
0.03184002,
0.011621478,
0.009491517,
-0.010431017,
0.010681978,
-0.013082206,
0.034439728,
0.02561101,
-0.010688414,
-0.01664072,
0.015134948,
0.0011470257,
-0.0150963385,
-0.035392098,
0.01940774,
0.013088641,
0.0025015778,
0.03431103,
-0.0034105112,
-0.019394869,
0.026228761,
-0.01579131,
-0.02368053,
0.019819574,
-0.011434865,
0.019420609,
-0.004546276,
-0.03256073,
0.003387989,
0.01059189,
0.0006056875,
0.00747095,
-0.025984235,
0.019382,
-0.0083074905,
-0.015611133,
0.0065764952,
-0.0032544644,
0.0034941654,
0.0073679914,
0.00209296,
0.008243142,
-0.011434865,
-0.01761883,
-0.0029278917,
-0.018017795,
-0.01846824,
-0.023320176,
-0.038480863,
0.028442377,
0.031016348,
-0.009523692,
0.0102379685,
-0.017168384,
0.015521044,
0.020643245,
0.022715291,
0.013616305,
0.00924699,
-0.010366667,
-0.013642045,
0.00089043303,
0.0009049116,
-0.00053289236,
-0.0006543516,
0.017992055,
0.016563501,
-0.026280241,
0.005971612,
0.008912373,
0.0005353055,
0.018609809,
0.011943224,
0.010257273,
0.022123279,
-0.007754087,
-0.0096974345,
-0.010977985,
-0.01491616,
0.0026914082,
0.0038448689,
-0.030861909,
0.022650942,
0.008899503,
0.009890483,
-0.033950675,
0.0047811507,
-0.031350963,
-0.045379106,
-0.032946825,
0.018288063,
-0.013680655,
-0.010913636,
-0.030939128,
0.0023053125,
0.012310015,
-0.010829982,
-0.02555953,
-0.015456694,
-0.008899503,
0.040874656,
-0.005784999,
-0.002932718,
-0.6247542,
-0.02365479,
0.008140182,
-0.011930354,
0.024336893,
0.012219926,
0.013925182,
-0.020990731,
-0.029574923,
-0.023024168,
-0.03158262,
0.017889097,
-0.0031273745,
0.015585393,
0.007850611,
-0.015726961,
-0.007741217,
-0.0145429345,
-0.012985682,
0.0041891374,
-0.004298531,
0.0013569652,
-0.015533914,
0.024208196,
0.023641922,
0.011409125,
0.013082206,
0.0023246172,
0.009877613,
0.03160836,
-0.017503,
0.010263708,
-0.03505748,
-0.010488931,
0.03431103,
0.011866005,
-0.017245604,
0.025713967,
0.020514546,
0.030321375,
0.005077157,
-0.014452846,
0.018880075,
-0.012007574,
-0.012535238,
0.027181132,
0.005041765,
0.0018387804,
-0.006756673,
-0.0023230086,
-0.0046202773,
0.0020479155,
-0.0071170293,
-0.00082769245,
0.020681854,
0.0063866647,
0.027052432,
-0.034079373,
-0.0150963385,
-0.014298407,
0.015726961,
0.016473413,
-0.029523445,
-0.016550632,
-0.015418084,
0.037682932,
-0.020874903,
-0.007998614,
-0.015726961,
0.014349887,
0.011782351,
0.019150343,
0.005257335,
-0.03256073,
0.020656114,
0.04839065,
0.0042052246,
0.00014609295,
0.0037193878,
0.0008124095,
0.018146494,
-0.003880261,
-0.01760596,
0.0063351854,
0.03194298,
0.0056627356,
-0.0050996793,
0.039124355,
-0.0019176082,
0.016872378,
0.004343576,
-0.007760522,
0.0046202773,
-0.04046282,
-0.017773269,
0.01755448,
0.0014961205,
0.0075867786,
-0.0044336645,
0.008056529,
-0.025752578,
-0.011183903,
-0.00046090165,
0.035546537,
0.011814525,
0.01747726,
-0.018262323,
-0.0053216843,
0.020540286,
-0.020797683,
0.02993528,
0.00873863,
-0.020154191,
-0.015031989,
-0.012200621,
-0.016177407,
-0.0062032696,
0.011473475,
-0.018944426,
-0.0049323714,
0.021325348,
-0.011685827,
-0.007837741,
-0.0066601494,
0.02102934,
0.00441436,
0.002189484,
-0.030115457,
0.00018721615,
-0.0024661857,
-0.007245728,
-0.024710119,
0.02014132,
-0.020025492,
0.0028217153,
-0.0044561867,
0.025791187,
-0.008989593,
-0.011949659,
-0.013088641,
0.0015612742,
0.0026463636,
0.024813078,
-0.0046556694,
-0.013667785,
-0.02011558,
-0.014491456,
-0.0067180637,
0.011293297,
0.011409125,
-0.02983232,
-0.014774592,
-0.007876351,
0.011473475,
0.0036325161,
0.0064349268,
0.007947135,
-0.0083461,
0.0016666461,
-0.005318467,
0.011724437,
0.0047875857,
-0.012129837,
0.02114517,
0.022316325,
-0.00029540336,
-0.014748853,
-0.014349887,
-0.012393669,
-0.012721851,
-0.010154314,
0.015598263,
-0.0006290141,
0.011402691,
-0.008983158,
-0.0015154253,
-0.023114257,
-0.019883923,
-0.012007574,
0.004485144,
0.0023777054,
-0.016550632,
-0.020012623,
-0.008584192,
0.01934339,
0.0063416203,
0.033178482,
0.0011615043,
0.0085777575,
0.011943224,
0.013461867,
0.035495058,
-0.005353859,
0.020553157,
-0.012786199,
-0.013114381,
0.03171132,
0.002411489,
0.0024951429,
0.03801755,
0.0038577386,
0.00030927866,
0.008243142,
-0.021248128,
0.028545335,
-0.02209754,
0.0054342956,
-0.011615043,
0.004826195,
0.010952245,
-0.0078120013,
0.018275192,
-0.0068531972,
-0.0036904307,
-0.013397518,
0.016962467,
-0.008339665,
-0.0025273175,
-0.014362757,
0.019999752,
0.0048004556,
0.026087193,
0.022702422,
0.009935527,
-0.0059523075,
0.010887897,
0.037193876,
0.0075224293,
0.004166615,
-0.023500353,
0.006058484,
0.03431103,
0.0049323714,
0.01675655,
-0.0044240123,
0.0095494315,
0.030347114,
-0.014388496,
0.02360331,
0.01402814,
-0.0035874718,
0.00792783,
0.016306104,
-0.009337079,
-0.0067116288,
-0.015456694,
0.034285292,
0.0060230917,
0.022663813,
0.028262198,
0.0006788848,
0.00064228615,
0.013333169,
0.012554542,
-0.0150963385,
-0.008597062,
-0.01141556,
0.034851562,
0.042830873,
0.018262323,
0.005019243,
-0.0051704636,
-0.003700083,
0.008654976,
-0.006534668,
-0.00197874,
0.014838941,
-0.021273868,
-0.020746205,
-0.013886572,
-0.022303456,
0.0142469285,
0.020823423,
-0.019755226,
0.0047940207,
-0.015662612,
0.023513222,
0.028725514,
0.016872378,
0.031222265,
-0.029266048,
-0.03608707,
0.015430954,
0.03508322,
0.000012360841,
0.00747095,
-0.015430954,
-0.026872255,
0.018699897,
-0.008757936,
0.0077926964,
0.019085992,
0.00047457585,
0.0019143907,
-0.015958618,
0.0039253053,
0.02725835,
-0.001501751,
0.03786311,
0.028622555,
0.011042334,
-0.026666338,
-0.024478462,
-0.0019658701,
0.0228826,
0.018069275,
-0.0068982416,
-0.008017919,
-0.010276578,
-0.0012717025,
-0.020720465,
-0.021376828,
-0.019626526,
0.004665322,
-0.030527294,
0.0098196985,
0.008873764,
0.016949598,
0.039356012,
0.009324209,
0.008153052,
-0.025701098,
-0.015778441,
-0.011151728,
0.023101388,
0.021466916,
0.013551956,
0.024272544,
0.011981834,
-0.003022807,
-0.019639397,
-0.017515872,
0.025919884,
0.002163744,
-0.00877724,
0.0007235271,
0.011981834,
-0.0022248758,
-0.0068467623,
-0.00508681,
-0.0012733112,
-0.0011719611,
0.019652266,
0.010347363,
-0.0064413617,
-0.0137063945,
0.028905692,
0.01589427,
0.020926382,
-0.020102711,
0.0080243535,
0.0075159944,
0.0011502432,
-0.0016441238,
-0.030218417,
0.020939251,
-0.006470319,
0.024838818,
-0.03075895,
-0.0007066354,
0.011531389,
-0.0036743432,
-0.0211323,
-0.0059136976,
-0.0011325472,
0.043371405,
0.02196884,
0.0220718,
0.0044787093,
-0.012509498,
0.024928907,
0.0023680532,
0.011782351,
-0.017013947,
-0.0015451869,
-0.0139766615,
0.005006373,
-0.022316325,
0.019137472,
-0.009124726,
0.0102379685,
-0.030141197,
-0.013030726,
0.004353228,
0.018262323,
-0.009337079,
0.008352535,
0.0046685394,
-0.01833954,
-0.013590566,
-0.019639397,
-0.02549518,
0.008249576,
0.0071685086,
-0.0022087886,
-0.0076060835,
-0.013358908,
-0.005308815,
0.013243079,
0.029729363,
0.0074194707,
-0.0058815232,
0.010707718,
0.029008651,
-0.0021090473,
-0.006315881,
0.0014301625,
-0.022432156,
-0.010469626,
-0.000037729787,
0.004066874,
-0.009028202,
-0.047180884,
0.0016175797,
0.025726838,
-0.020952122,
-0.036395945,
-0.015752701,
-0.00876437,
0.018802857,
0.00459132,
0.017515872,
-0.00441436,
-0.017901966,
-0.020591766,
-0.03521192,
-0.015469564,
-0.021865882,
-0.00050996797,
0.006000569,
-0.021788662,
0.010283013,
-0.018789986,
-0.020926382,
0.024735859,
-0.02037298,
0.008938113,
0.0042599216,
0.008687152,
0.03268943,
-0.043191228,
0.017889097,
0.030269897,
-0.011692262,
0.0150963385,
0.008944549,
0.033899195,
-0.023538962,
-0.02906013,
0.016563501,
-0.0021267433,
-0.012264971,
-0.02011558,
-0.017168384,
0.0025144476,
0.023667661,
0.00702694,
-0.031402443,
-0.032972567,
-0.0013891398,
-0.007670433,
0.009999876,
-0.0071492037,
-0.002506404,
0.003693648,
0.023307305,
-0.012310015,
-0.011203208,
0.019497829,
-0.03431103,
-0.0012757243,
0.043294188,
-0.010450321,
0.009742479,
0.03248351,
0.01755448,
0.00055219716,
-0.0022827904,
0.015212167,
-0.01665359,
-0.014285537,
-0.014890421,
0.034722865,
0.031556882,
0.009607346,
0.025971364,
0.026537638,
0.013461867,
0.00041082987,
0.014349887,
-0.043371405,
-0.010218664,
-0.019948274,
0.014349887,
-0.0012837679,
-0.0071878135,
0.009806829,
-0.03436251,
0.022329196,
0.017026816,
-0.015327996,
-0.01683377,
-0.0030887648,
-0.038300686,
-0.041878503,
-0.004395055,
-0.0026608421,
0.027438529,
-0.055649247,
-0.0046202773,
-0.0219431,
0.008545583,
0.0073422515,
-0.024426982,
0.02370627,
-0.024426982,
0.027206872,
-0.018030666,
-0.01491616,
-0.010598324,
-0.019214692,
0.0011438082,
0.010572585,
0.015134948,
0.00062539446,
0.014787462,
0.008262446,
-0.005562994,
-0.009736044,
0.012554542,
-0.0011027856,
-0.012168447,
0.005305597,
-0.014890421,
-0.008693586,
0.0020816987,
-0.011968964,
-0.03405363,
-0.004034699,
0.01836528,
-0.013281689,
0.010533975,
-0.016241755,
-0.015430954,
0.012458018,
0.0023841404,
-0.013358908,
-0.0017374302,
0.03606133,
0.03518618,
-0.0022248758,
-0.034388248,
-0.010920071,
-0.025121955,
0.021775793,
0.04671757,
-0.0018130407,
0.016048707,
-0.027490007,
-0.005830044,
0.017322823,
0.020797683,
-0.014439976,
0.015263647,
0.012805505,
0.0007331795,
0.011750177,
0.0011888527,
-0.036395945,
0.02380923,
-0.027103912,
0.017374303,
-0.025366481,
-0.019266171,
-0.012606022,
0.024388373,
-0.037940327,
0.042573474,
-0.014851811,
-0.0019916098,
-0.02368053,
-0.042676434,
-0.007284337,
0.029549183,
0.0035456447,
0.012226361,
-0.020759074,
-0.0022683118,
-0.00070382014,
-0.0064188396,
-0.018326672,
-0.018661289,
0.009266295,
0.038403645,
-0.002919848,
0.013243079,
0.010784937,
-0.0067373686,
0.02375775,
-0.040565778,
-0.008719326,
-0.018596938,
-0.010804242,
-0.0057238676,
0.04316549,
0.010366667,
-0.017940575,
-0.008635672,
-0.027052432,
-0.0020720465,
-0.04404064,
-0.014723113,
0.0041537452,
-0.01839102,
-0.0351347,
-0.0037933893,
0.011660088,
0.01671794,
0.0027155392,
-0.005775347,
-0.00703981,
0.034002155,
0.0019433479,
0.006122833,
0.005762477,
0.02029576,
-0.01936913,
-0.00025096216,
-0.015405215,
-0.027464269,
-0.008075833,
-0.020784814,
-0.0134232575,
-0.014735983,
-0.010797807,
0.029266048,
0.00570778,
-0.007670433,
0.0068338923,
0.007876351,
0.018300932,
-0.012065488,
-0.028751254,
0.006756673,
-0.01933052,
0.0030131545,
-0.026254501,
-0.001385118,
-0.016280364,
-0.009343514,
-0.00745808,
0.0059169154,
-0.01836528,
0.0054182084,
-0.0051962035,
-0.004066874,
-0.02736131,
-0.007960005,
-0.020540286,
-0.006788848,
-0.027206872,
0.0020961773,
-0.008481233,
-0.008313926,
-0.017760398,
0.023101388,
-0.0032287245,
0.033049785,
-0.02290834,
-0.018146494,
-0.011563564,
-0.02985806,
-0.0099677015,
-0.004893762,
-0.029600663,
0.03608707,
0.019703746,
-0.0012306798,
-0.025829796,
-0.010167184,
-0.030527294,
-0.028390897,
0.01012214,
-0.006692324,
0.017824747,
0.023899319,
0.0035520797,
0.007869915,
0.007277902,
-0.014671633,
-0.05467114,
-0.0015363388,
0.00092019455,
-0.013281689,
0.01833954,
0.015649742,
-0.014504326,
-0.02037298,
0.012934203,
0.003838434,
-0.015546783,
0.026717816,
-0.03505748,
-0.0031016348,
-0.014710243,
-0.003159549,
0.008378275,
0.001484055,
0.015688352,
-0.01930478,
0.015675481,
-0.0048969793,
0.018262323,
-0.023667661,
-0.0028024106,
-0.0022554419,
-0.011190338,
0.014285537,
-0.012959942,
-0.015997227,
-0.005553342,
-0.02736131,
0.014645893,
0.013783613,
-0.018970164,
0.032895345,
0.001081872,
-0.00004504449,
-0.038995657,
-0.009530127,
-0.01501912,
0.007303642,
0.009176206,
-0.025649618,
-0.0047940207,
-0.003831999,
0.015289386,
0.0058622183,
-0.022972688,
-0.012689676,
-0.0019353043,
-0.05456818,
0.0071878135,
-0.0043854024,
0.00071427686,
-0.0021122647,
0.024105236,
-0.0049001966,
0.009594476,
-0.028802732,
-0.010089966,
0.0017824747,
0.019201823,
-0.011171033,
-0.0100964,
0.00970387,
-0.0058911755,
-0.008519843,
-0.0220718,
0.009941962,
0.16607259,
-0.009922657,
0.0056627356,
0.02203319,
0.037528493,
-0.0031096784,
0.0016859508,
0.010733458,
-0.011106684,
0.010128574,
0.033770498,
-0.0052315956,
-0.017091166,
0.0025498397,
0.060900148,
-0.034851562,
-0.038789738,
-0.03261221,
-0.019201823,
-0.006270836,
0.0011977007,
0.00551795,
0.04499301,
0.005157594,
0.02474873,
0.011087379,
-0.020862034,
0.007863481,
0.04823621,
-0.002992241,
-0.02990954,
-0.017863357,
0.00701407,
-0.013873702,
-0.00075570174,
-0.0017969534,
-0.021917362,
-0.002915022,
-0.009002463,
0.006306228,
0.010360233,
0.005456818,
-0.020836294,
0.020179931,
0.0016569936,
-0.0030887648,
0.0050996793,
-0.007760522,
-0.007310077,
-0.0149419,
-0.0421359,
-0.0019272605,
0.02558527,
-0.00042068335,
-0.009343514,
0.0074194707,
0.0015186428,
0.026795035,
-0.04216164,
0.019587917,
-0.006756673,
0.009317774,
-0.013255949,
0.017348563,
-0.013017857,
0.014568674,
-0.0018500414,
0.016331844,
-0.025263524,
-0.0063544903,
0.040668737,
0.008326795,
-0.0131529905,
0.00461706,
-0.01581705,
-0.02377062,
0.04306253,
0.022457894,
0.0019063471,
-0.0044594044,
-0.0036839957,
0.008809415,
-0.040308382,
0.001211375,
-0.041955724,
-0.022149019,
0.022547984,
0.020746205,
-0.011878875,
-0.00067285204,
0.001352139,
0.0039060006,
0.002499969,
0.0009451299,
0.037528493,
-0.0124644535,
-0.012786199,
0.0023760968,
-0.024028016,
-0.008011484,
-0.017065426,
0.06398891,
0.045276146,
0.019922534,
-0.006235444,
0.010694848,
-0.010894331,
0.030578772,
-0.009337079,
-0.011460605,
0.024903167,
-0.038197726,
0.008822285,
-0.0010038486,
-0.006962591,
0.03518618,
0.022264848,
-0.036601864,
0.0076189535,
0.011840265,
-0.025212044,
0.0015918401,
0.019382,
0.0024983604,
-0.025971364,
-0.0025241,
-0.013989531,
0.020733334,
0.0026334939,
-0.020475937,
-0.018300932,
-0.01576557,
-0.00067003677,
-0.00078345236,
0.015521044,
-0.010495366,
0.006476754,
-0.000060779894,
-0.015456694,
0.004610625,
-0.010817112,
0.021878751,
0.012290711,
0.018995903,
-0.0013465084,
-0.0013617914,
-0.00702694,
0.009748914,
-0.007760522,
-0.010463191,
-0.025392221,
-0.030321375,
0.0054889927,
-0.012104098,
0.031119306,
-0.03516044,
-0.01104877,
-0.027901843,
-0.01057902,
0.0030115459,
-0.018944426,
0.007766957,
0.034825824,
-0.013268819,
0.0148132015,
-0.016627852,
-0.1580418,
0.019755226,
0.00961378,
0.00077379995,
-0.0009732827,
0.015546783,
-0.01012214,
-0.046279993,
-0.008384709,
-0.0150834685,
0.018300932,
0.007947135,
-0.047644198,
-0.026614858,
0.012811939,
0.010501801,
0.0069883307,
0.022998428,
0.025237784,
0.029626403,
0.005550124,
-0.040926136,
0.018107884,
-0.017412912,
0.013030726,
0.02105508,
0.01059189,
0.041106313,
-0.00093145564,
-0.012194186,
-0.004118353,
-0.009768219,
0.0131916,
0.033101264,
0.0022811815,
-0.0028152806,
-0.006981896,
-0.031145046,
-0.008925243,
0.014748853,
0.02016706,
0.0026881907,
0.027798884,
-0.0057656947,
0.008745066,
0.029600663,
0.016357584,
-0.007921395,
0.035675235,
0.018004926,
0.023937928,
0.0050095906,
0.014169709,
0.004977416,
-0.00039212836,
0.0017615613,
0.016859509,
0.014761723,
0.0042856615,
-0.012895593,
0.021518396,
-0.017374303,
0.019472089,
0.004671757,
-0.015057729,
-0.015508174,
0.004784368,
0.024298284,
-0.017322823,
-0.0036132114,
0.01683377,
-0.03178854,
0.008719326,
-0.026537638,
0.029471966,
-0.009980571,
0.0010778502,
0.026666338,
-0.013886572,
-0.0046974965,
-0.019768095,
0.019999752,
-0.020566026,
-0.028905692,
0.0073422515,
0.009858308,
0.006422057,
0.015572523,
0.0032544644,
-0.0039349576,
0.029471966,
-0.033101264,
0.013062902,
-0.027695926,
0.0018838248,
0.008532713,
-0.017786138,
-0.005408556,
-0.028828472,
0.009253425,
0.023513222,
-0.019549308,
0.0042373994,
0.04218738,
0.049832072,
0.03366754,
0.0022055712,
0.0148132015,
0.041955724,
-0.013963792,
-0.009015333,
-0.0000694771,
-0.011962529,
0.023950798,
-0.0049001966,
0.059458725,
0.018815726,
0.019163212,
0.035366356,
-0.025546659,
0.061929736,
-0.007831306,
0.021853011,
0.00531525,
0.0025691446,
0.0015950575,
-0.12519793,
-0.031093566,
0.017078295,
0.01851972,
-0.0008083877,
-0.00462993,
-0.015443824,
0.020128451,
-0.000052736235,
0.035623755,
-0.023307305,
0.0016207972,
0.020360108,
-0.016228886,
-0.003478078,
0.018185103,
-0.00923412,
0.026563378,
-0.035469316,
0.026087193,
-0.008410449,
0.009240555,
0.0031273745,
-0.016344715,
-0.0071620736,
-0.008700022,
-0.018043535,
0.0044883615,
0.023294436,
0.011917485,
0.0034040762,
0.0050514177,
-0.00972961,
0.0051640286,
-0.0011188729,
-0.00066239526,
0.00018440087,
-0.0061196154,
0.01008353,
-0.009787524,
-0.008532713,
0.006257966,
0.012618892,
0.01496764,
-0.0062097046,
-0.013912312,
-0.03598411,
-0.0028699774,
0.007490255,
-0.0075803436,
-0.03783737,
-0.016357584,
-0.020450197,
0.010823547,
0.0057367375,
0.012393669,
-0.00015212569,
0.014787462,
-0.012792635,
0.006975461,
-0.024246804,
0.002565927,
-0.01666646,
0.007760522,
0.029549183,
0.004124788,
-0.025302133,
-0.017425781,
-0.003693648,
-0.014684503,
-0.010772067,
-0.016357584,
-0.017348563,
-0.0018130407,
-0.007393731,
-0.0012982464,
0.00017726213,
-0.0012821591,
0.006277271,
-0.026640598,
-0.0040443516,
-0.015250777,
0.02379636,
-0.00060086127,
-0.005144724,
0.01664072,
0.0056048213,
-0.036112808,
0.022110408,
-0.009658826,
0.0030356767,
0.034130853,
0.03184002,
-0.042547736,
-0.009362819,
0.031042088,
-0.0061324853,
-0.002818498,
0.028725514,
0.028674034,
-0.016550632,
-0.00882872,
-0.045430582,
0.01848111,
-0.008423319,
0.011261122,
0.008217402,
0.010347363,
0.00042068335,
0.0139766615,
0.017116906,
0.0018194756,
-0.011055204,
0.018056404,
0.0020366544,
-0.00041706368,
-0.034671385,
-0.00459132,
0.016885249,
0.028287938,
0.012174882,
0.030578772,
-0.005575864,
0.010533975,
-0.015624003,
0.010064226,
-0.028287938,
0.011003725,
-0.025919884,
0.015379475,
-0.01683377,
-0.022290587,
0.020154191,
-0.02383497,
-0.055494808,
-0.003825564,
-0.008410449,
-0.0027734535,
0.010270143,
0.011904615,
0.021647094,
0.027670186,
-0.032792386,
-0.029291786,
0.0003507035,
0.00037644323,
-0.018403891,
0.0037097353,
-0.006248314,
-0.0039027832,
-0.005990917,
-0.01940774,
0.048210472,
0.009916223,
0.009684565,
-0.044478215,
-0.025855536,
0.001499338,
-0.0201928,
-0.00219431,
-0.009388559,
0.0017824747,
0.024774468,
0.015353736,
-0.011331907,
0.018777117,
-0.00701407,
-0.03328144,
-0.010431017,
-0.026112933,
-0.012200621,
-0.013320299,
-0.02011558,
-0.0012902028,
-0.00012568217,
0.015559653,
0.020990731,
0.010868591,
-0.033847716,
0.011351211,
-0.0008823894,
0.021016471,
0.013487606,
-0.011531389,
-0.002031828,
0.01410536,
0.038197726,
0.0027300178,
-0.015250777,
0.016087318,
0.00066802587,
0.011988269,
-0.013822223,
-0.0019497828,
0.025070475,
-0.0054471656,
-0.029523445,
-0.009633086,
-0.014208319,
0.016267495,
0.0176317,
0.018648418,
0.021454046,
0.006422057,
0.016589241,
-0.006257966,
-0.030939128,
0.009176206,
-0.042933833,
-0.015958618,
-0.0030002845,
0.0016634286,
0.0070977244,
-0.008584192,
0.0027654099,
0.0013802918,
-0.0038899132,
-0.009304904,
-0.015958618,
0.0028651513,
-0.0099677015,
0.020849163,
-0.0042373994,
-0.0013722482,
0.0246329,
0.013873702,
0.013487606,
-0.017245604,
0.016048707,
-0.023255825,
0.01012214,
-0.0056530833,
0.0026077542,
-0.0184425,
-0.037477013,
-0.015546783,
0.0005300771,
-0.030939128,
0.018635549,
0.03516044,
0.002686582,
0.08169783,
0.023217216,
-0.024002276,
0.022161888,
-0.023899319,
0.019678006,
0.013107946,
0.011080944,
-0.012200621,
-0.02196884,
0.008223836,
-0.010463191,
-0.0022538332,
-0.016898118,
-0.03243203,
0.013114381,
-0.007644693,
0.0028361941,
0.00023467375,
0.0012250491,
0.023963667,
-0.016820898,
-0.011196773,
0.04934302,
-0.017387172,
0.022702422,
0.017451521,
0.016512021,
0.009916223,
0.0065636253,
0.0052122907,
0.009941962,
-0.046099816,
-0.016589241,
0.007747652,
-0.018648418,
0.010469626,
-0.0026190153,
0.025315002,
0.017451521,
-0.014735983,
0.015302256,
-0.019201823,
-0.012445148,
-0.014452846,
-0.018056404,
-0.02111943,
0.008706456,
-0.0033204223
] |
CONTEXT Despite improvements in mental health services in recent decades, it is unclear whether the risk of mortality in schizophrenia has changed over time. OBJECTIVE To explore the distribution of standardized mortality ratios (SMRs) for people with schizophrenia. DATA SOURCES Broad search terms were used in MEDLINE, PsychINFO, Web of Science, and Google Scholar to identify all studies that investigated mortality in schizophrenia, published between January 1, 1980, and January 31, 2006. References were also identified from review articles, reference lists, and communication with authors. STUDY SELECTION Population-based studies that reported primary data on deaths in people with | [
0.007206308,
-0.0014646838,
0.022048865,
-0.06273274,
-0.01646606,
0.017903473,
-0.026117252,
0.016863916,
-0.032341756,
-0.019661736,
-0.0053838757,
0.03585828,
0.0009304672,
0.017351609,
-0.0141046,
0.020932304,
0.03786039,
-0.011435121,
0.025732232,
-0.004190311,
-0.008528213,
0.011723887,
0.00045280065,
0.0061571263,
-0.005178531,
0.030930014,
0.026155755,
-0.0270028,
0.00017787164,
-0.02263923,
0.002521887,
-0.012846865,
-0.03721869,
-0.028029524,
-0.029723614,
0.0051304037,
0.007873678,
0.003298346,
-0.0054640886,
-0.042018615,
-0.011865062,
-0.0015272497,
0.005624514,
-0.019944083,
-0.004912225,
0.007065134,
-0.018545175,
-0.028234867,
-0.023614617,
0.008046937,
0.028003855,
0.033137467,
-0.024333322,
-0.012044738,
0.017698128,
-0.02442316,
0.0023406064,
0.003474814,
0.008489711,
0.00076242164,
0.010851173,
-0.02369162,
-0.033445485,
0.0036127795,
-0.026271261,
-0.011319615,
-0.032495767,
0.005011689,
0.0155163435,
0.016799746,
0.041094568,
0.024538666,
-0.0050598164,
0.01795481,
0.005656599,
0.0096832765,
-0.017582621,
0.00840629,
0.007026632,
-0.007135721,
0.0325471,
-0.018224323,
0.010825505,
0.0022539767,
0.022048865,
-0.011582713,
-0.005043774,
0.016992256,
-0.005929322,
0.009587021,
0.012224414,
0.0141559355,
0.0077581718,
0.016658572,
0.0023710872,
0.009144247,
-0.007873678,
0.020637121,
-0.024808181,
-0.030493656,
0.0019251046,
-0.00999771,
-0.03267544,
-0.0078159245,
0.0032020907,
-0.0015537199,
-0.0018994366,
-0.0019074578,
-0.00816886,
-0.017621124,
-0.013886421,
0.02913325,
0.0012817988,
-0.010222306,
0.016889585,
-0.004758217,
-0.0077004186,
-0.013462898,
-0.0052619525,
-0.01649173,
0.023601782,
-0.013475732,
0.03110969,
-0.010896092,
0.022818906,
-0.0031202738,
-0.029441267,
0.0026309763,
0.0009769906,
-0.011922815,
-0.004928268,
0.0025266998,
0.01502865,
0.0038149157,
-0.00020193546,
0.013527068,
-0.021638175,
-0.0021657427,
-0.005932531,
-0.045740485,
0.0097153615,
0.006699364,
-0.0043186513,
-0.02238255,
-0.007636248,
0.02951827,
0.030134303,
-0.0022828532,
0.011499291,
0.0040876386,
0.01687675,
-0.021676678,
-0.0040972643,
0.018006146,
0.0035389839,
0.0002520684,
-0.015657518,
0.024448829,
-0.019417888,
-0.04104323,
-0.014682131,
0.0030015588,
-0.022587894,
0.023640284,
-0.011704636,
0.018108817,
0.0036384477,
-0.02356328,
0.0069881296,
-0.0025684105,
-0.0052812034,
0.03839942,
-0.020585785,
0.029312925,
-0.009182749,
0.0013547924,
-0.019507727,
0.025013525,
-0.017287439,
-0.017300274,
-0.01642756,
0.011922815,
0.023037085,
0.016594402,
-0.02337077,
0.007026632,
0.025834903,
0.0009152268,
-0.027054137,
-0.024641339,
0.016440393,
0.0054255864,
0.00982445,
-0.029749284,
-0.6386214,
-0.025257373,
-0.020624287,
-0.00748224,
0.004626668,
0.02874823,
0.006048037,
0.020457445,
-0.026925797,
0.038810108,
0.004039511,
0.020072425,
0.017056426,
-0.04645919,
-0.026219925,
-0.008598801,
-0.0005418367,
0.0108896755,
-0.004658753,
-0.0017165516,
-0.019982586,
0.031597383,
-0.030339649,
0.009356009,
-0.021407163,
0.013899256,
0.038219742,
-0.03483156,
0.01668424,
0.040298857,
-0.02543705,
0.018314162,
0.0135014,
0.027490493,
0.04319935,
-0.02556539,
-0.020739794,
0.020098092,
0.0056918925,
0.026848793,
-0.0139634255,
0.015670352,
0.040298857,
0.011146355,
-0.015696019,
0.03272678,
0.027464826,
0.003165193,
0.016581567,
0.0005201793,
0.027439158,
-0.006477977,
-0.009593438,
0.001598639,
0.012089657,
0.0025331168,
0.012185913,
-0.02416648,
-0.005720769,
0.022267044,
-0.016838249,
-0.006641611,
-0.024692675,
0.0059999092,
-0.010581658,
0.029826287,
0.006680113,
0.0113966195,
0.016196547,
0.0069432105,
-0.000040181545,
0.034215525,
-0.0072833123,
-0.0032774906,
0.01954623,
0.014181604,
0.004260898,
0.007450155,
-0.026232759,
-0.016915252,
-0.01042765,
0.0014542561,
-0.021034976,
-0.033958845,
0.0029566397,
-0.003222946,
-0.014733467,
0.007578495,
0.007995601,
0.03241876,
-0.01792914,
-0.020277768,
0.012468261,
-0.006917543,
0.013912089,
0.020842467,
0.0098437015,
-0.008656554,
0.016632903,
-0.021805018,
-0.028645556,
-0.0045015365,
0.021561172,
0.032367427,
0.019097038,
0.030673333,
-0.030673333,
-0.0068084532,
0.039631486,
-0.021124814,
0.0017967643,
0.0053870846,
0.005018106,
-0.0036673243,
0.01109502,
-0.0282092,
0.039118126,
-0.014386948,
-0.006388139,
-0.033599492,
0.033573825,
0.00567585,
0.018853191,
-0.006641611,
0.008431958,
0.018429669,
0.012262916,
0.0045785406,
0.0136810765,
-0.026977133,
0.0077902568,
-0.021612508,
0.021471333,
-0.009375259,
0.01948206,
-0.022780405,
-0.0018545174,
-0.021060644,
-0.013135631,
-0.022947246,
-0.0361663,
0.0019459599,
0.0030689377,
-0.015811525,
0.0027288357,
-0.049796037,
0.008444793,
-0.00089838216,
0.010594493,
0.0073410654,
-0.0034587714,
-0.0022539767,
-0.01117844,
0.024153646,
-0.00827795,
-0.015002982,
-0.008271533,
-0.016478896,
-0.006080122,
-0.0041871024,
0.03241876,
0.017903473,
-0.015927032,
0.0020053172,
-0.013642575,
-0.04214696,
-0.003147546,
0.019212544,
-0.009465097,
-0.029492602,
-0.016594402,
-0.007065134,
0.016928086,
-0.00017606685,
-0.0026694783,
0.027233813,
0.0062918835,
0.00546088,
-0.00625659,
-0.005069442,
0.014643629,
-0.015079986,
-0.0119677335,
-0.002356649,
0.040042177,
0.013450064,
0.016478896,
-0.0097795315,
0.0041004727,
0.002186598,
0.008053354,
0.035550267,
-0.0075849122,
0.018044647,
-0.0006100175,
0.012333504,
-0.0036480732,
-0.00089838216,
0.008354954,
0.025270207,
0.01601687,
-0.0024513,
0.0025684105,
-0.007969933,
0.004517579,
0.006429849,
0.006275841,
-0.009587021,
0.010671496,
0.012872533,
0.012853282,
-0.0139634255,
-0.00042231983,
-0.015619015,
-0.007957099,
0.013071461,
0.01006188,
-0.011441538,
-0.0010499841,
0.017017925,
0.014656463,
-0.001239286,
0.02072696,
0.0054576714,
0.0011727095,
0.011454373,
0.014605127,
0.034523543,
0.0073474827,
0.0049956464,
-0.014592293,
0.02547555,
0.022857409,
0.012262916,
0.019161208,
0.0214585,
-0.006250173,
-0.02537288,
0.023165425,
0.01356557,
-0.003962507,
0.013655408,
0.00073274295,
0.0021432831,
-0.0026774995,
-0.022433886,
0.02674612,
0.0039272136,
-0.00913783,
0.018493839,
-0.03562727,
0.0057496456,
0.0012304627,
0.0039111706,
0.014848974,
-0.0031828396,
-0.020996474,
-0.0018320578,
0.010658663,
0.01747995,
0.03123803,
-0.026130086,
0.006648028,
-0.01773663,
0.0073346486,
0.00187056,
-0.024512999,
0.0005927718,
0.013475732,
-0.004658753,
-0.01821149,
0.0135527365,
-0.000979397,
-0.03483156,
0.00022660085,
-0.000040256746,
0.010960262,
0.007867261,
0.006872623,
0.004260898,
-0.038476422,
-0.015259663,
0.01646606,
0.023537612,
-0.005428795,
-0.036474314,
0.000492907,
0.007578495,
-0.01919971,
0.0076875845,
-0.0077645886,
-0.0010162948,
0.0037154518,
-0.005069442,
0.0010989138,
0.0021625343,
0.008714307,
-0.006394556,
0.010267224,
0.0045913747,
0.0042256047,
0.008245865,
0.0017470324,
-0.0061346665,
0.009003073,
-0.005765688,
-0.032213416,
-0.010864007,
-0.014271442,
0.0021721597,
0.0055699693,
-0.02012376,
-0.035421927,
0.037552375,
0.012776278,
-0.0037764136,
-0.00827795,
-0.018827522,
0.01141587,
-0.012070406,
0.0008073407,
-0.01913554,
-0.011345283,
-0.01614521,
0.053132888,
0.024063807,
-0.0009256545,
0.015696019,
0.021009307,
0.010292892,
-0.002616538,
-0.011018015,
0.008528213,
0.013591238,
0.01128753,
-0.00410689,
0.01276986,
0.00044477938,
0.023383604,
0.009946374,
-0.0029341802,
-0.015901364,
-0.01416877,
-0.0051271953,
-0.0053517907,
-0.012295001,
0.02263923,
0.047973607,
0.014540956,
-0.01633772,
0.007527159,
0.019982586,
0.0060704965,
-0.010973096,
-0.014707799,
0.0030625206,
-0.00797635,
0.037963063,
-0.0054063355,
0.02861989,
0.03388184,
-0.013398728,
0.0049186423,
0.007873678,
0.00068541744,
-0.013860753,
0.011544211,
0.0064683515,
0.02257506,
-0.013135631,
-0.007122887,
0.029697947,
0.020046756,
-0.013976259,
0.025360044,
-0.00840629,
-0.0034266862,
-0.015426505,
0.01189073,
0.013231886,
0.008926068,
0.0057721054,
-0.03098135,
-0.011832977,
-0.0073153977,
-0.017390111,
0.0036256136,
-0.001220035,
-0.01948206,
-0.0024978232,
-0.031340703,
0.011653299,
-0.020354772,
-0.004892974,
0.0190072,
-0.015773024,
-0.033034794,
0.002257185,
0.009574187,
0.0067763682,
0.008592384,
-0.011293947,
-0.0040812218,
0.020264935,
-0.0047421744,
-0.0051977825,
0.004735757,
-0.016825415,
-0.0019331259,
0.0037892475,
0.0025523677,
-0.02582207,
-0.01653023,
0.046536196,
-0.004337902,
0.008983822,
-0.003481231,
-0.007559244,
0.0018737685,
0.01945639,
0.025039194,
0.03506257,
0.0052427016,
-0.014746301,
0.016286384,
-0.021894857,
-0.030262645,
-0.018314162,
0.027516162,
-0.02887657,
-0.007071551,
0.0030384567,
0.016645737,
-0.021407163,
0.012333504,
-0.019623233,
0.0028988868,
0.0044887024,
0.043635704,
-0.00021757693,
0.016953755,
0.03667966,
0.009144247,
0.0005358208,
-0.0025652018,
0.0030432695,
0.013591238,
0.024923688,
-0.021432832,
-0.0069432105,
-0.01681258,
-0.005239493,
-0.03693634,
-0.013668243,
-0.0033464734,
0.013706745,
-0.008335703,
-0.03365083,
-0.0039657154,
-0.0104148155,
-0.013539903,
-0.0052812034,
0.0018497047,
-0.002483385,
0.0068597896,
0.00823303,
-0.027593166,
-0.0140275955,
0.030621998,
-0.02874823,
0.004039511,
0.008759226,
0.020842467,
0.010992347,
-0.011005181,
0.0034780223,
-0.009356009,
0.020110926,
-0.0024817807,
-0.026797457,
0.00014488418,
-0.0040042177,
0.046356518,
-0.0011165607,
0.016004037,
0.014925978,
-0.006263007,
0.019379387,
0.007135721,
-0.014258608,
0.009606272,
0.0036063627,
0.010209471,
0.04989871,
0.025206037,
-0.0014678923,
-0.0037058264,
0.005409544,
0.030031633,
0.00034932626,
-0.0023341894,
0.0026566444,
-0.010010544,
-0.034215525,
0.000031809344,
-0.0028571761,
-0.0017005091,
-0.000284354,
-0.037013344,
-0.023473442,
0.017839303,
0.016504563,
-0.0018176195,
-0.012840448,
-0.0069303764,
-0.043225016,
0.018249992,
0.007129304,
0.008977405,
-0.0065132705,
-0.0030480823,
-0.0208553,
0.0014831327,
-0.0021625343,
-0.004960353,
0.03203374,
0.025052028,
-0.013000873,
0.007225559,
0.024512999,
-0.036217634,
-0.0071998914,
-0.011467206,
-0.026104419,
0.00316038,
-0.01945639,
0.008874732,
-0.013629741,
-0.0013668243,
-0.016196547,
0.009850118,
0.018519506,
-0.031212363,
-0.021445666,
0.01649173,
-0.008823396,
0.024204982,
0.007007381,
0.014066097,
0.011832977,
-0.038707435,
-0.022626396,
0.016324887,
0.022369716,
-0.004575332,
0.017107762,
0.020880967,
-0.009349591,
-0.0063047176,
0.0024705508,
0.011666134,
-0.027926851,
-0.03916946,
-0.0015569284,
0.029672278,
-0.012262916,
-0.02938993,
-0.00011019219,
-0.015272496,
0.023126923,
0.003943256,
-0.019020034,
0.009221251,
-0.03293212,
0.006150709,
0.0282092,
-0.023165425,
0.012712107,
-0.005200991,
-0.01208324,
-0.015747355,
-0.007828759,
-0.027926851,
0.008881149,
0.007963516,
0.027721506,
-0.028517216,
0.014848974,
0.015798692,
0.03511391,
0.0068918746,
0.00070667383,
-0.035575934,
0.031725723,
-0.0018208281,
-0.00067017705,
0.0082907835,
-0.034754556,
-0.013783749,
0.003766788,
0.0040555536,
-0.009702527,
-0.015054318,
0.010241557,
0.0159527,
0.029338595,
-0.0055154245,
-0.018545175,
-0.033188805,
-0.030467989,
0.0020454237,
-0.015901364,
-0.010568825,
-0.031186694,
-0.009413761,
0.011929232,
-0.00071268977,
0.029364262,
0.0014037221,
-0.01789064,
0.0005618899,
0.017749464,
-0.041633595,
0.027490493,
0.02139433,
-0.03798873,
-0.029954627,
-0.0036512818,
-0.007873678,
-0.027618835,
-0.017313108,
0.00069504295,
-0.040760882,
-0.023999637,
-0.000026921385,
0.012763443,
0.0021625343,
-0.00023301787,
0.014066097,
-0.0027368572,
-0.016543066,
-0.013219052,
-0.006458726,
0.02977495,
-0.035935286,
0.017531285,
0.0061892113,
-0.00140292,
0.0056854757,
-0.027079806,
0.03403585,
0.015683185,
-0.027593166,
-0.011698219,
-0.013058626,
0.011236194,
-0.021227486,
0.006465143,
-0.0064234324,
0.015310999,
-0.015490675,
0.010979514,
0.014399783,
-0.0013876796,
-0.0140917655,
0.0013580009,
0.012243666,
-0.011499291,
-0.010434067,
-0.010023378,
0.0040427195,
-0.0034844393,
-0.023139758,
0.0050662337,
-0.012936703,
0.031212363,
0.020701291,
0.0042673154,
-0.023704454,
-0.009202,
-0.040067844,
0.006131458,
0.003259844,
0.014592293,
0.019443557,
0.02674612,
-0.0032823035,
-0.008361371,
0.013122796,
-0.015413671,
-0.031032687,
-0.032136414,
0.018609345,
-0.026027415,
0.020085258,
-0.0048769317,
-0.02113765,
0.0059389477,
0.030596329,
-0.012615852,
-0.015747355,
0.020008255,
-0.009477932,
0.00827795,
-0.008887567,
-0.009112162,
-0.0155805135,
-0.009323923,
0.011236194,
-0.03472889,
-0.0025234914,
0.004915434,
-0.00531008,
0.014374115,
0.016928086,
0.016093874,
0.00870789,
-0.012359171,
-0.015837194,
-0.009144247,
0.016915252,
-0.0151056545,
0.028825233,
0.007841593,
0.01913554,
0.014784804,
-0.007886512,
-0.007469406,
0.006250173,
0.008849064,
0.009400927,
-0.0071678064,
0.018262826,
-0.0087656425,
0.0056662248,
-0.008072605,
-0.008464043,
0.009689693,
0.016902419,
-0.04461109,
-0.032264754,
-0.012968788,
0.01627355,
0.0064138067,
-0.010742084,
-0.006060871,
0.0027320443,
-0.049873043,
0.016889585,
-0.016786912,
-0.0063913474,
0.0038598347,
0.00036195977,
-0.018070316,
-0.004071596,
0.0064009726,
-0.015041484,
-0.016170878,
-0.00567585,
0.0208553,
0.18409133,
-0.0029999546,
-0.0019924832,
0.031315036,
-0.0052106166,
-0.007803091,
0.018044647,
-0.004912225,
0.00011670947,
0.035652936,
0.012859698,
-0.009067243,
-0.0043571535,
0.020803964,
0.026412435,
-0.009381676,
-0.016453227,
-0.01276986,
-0.00013555944,
0.0067442833,
-0.0007291334,
0.007835176,
-0.023486277,
-0.02107348,
0.0043828213,
0.017402945,
-0.0052619525,
-0.0014967688,
0.02833754,
0.0025619934,
-0.0028812399,
-0.017287439,
0.023678787,
0.014823305,
-0.022947246,
-0.019020034,
-0.0061699604,
-0.020213598,
0.008618051,
0.0064619347,
-0.0035389839,
-0.0017181558,
-0.018891694,
-0.011922815,
0.0077838395,
0.03218775,
0.000556275,
-0.003280699,
-0.0052234507,
-0.0108896755,
-0.05125912,
-0.007828759,
0.0120319035,
0.018904528,
0.011595547,
-0.0076747504,
0.02235688,
0.013745246,
-0.013193384,
-0.026207091,
0.010113216,
-0.026091585,
-0.029954627,
0.018724851,
-0.01429711,
0.02158684,
-0.0045336215,
0.016709909,
-0.018891694,
-0.01588853,
0.027387822,
-0.0021272406,
-0.026720451,
-0.024512999,
0.0052041993,
-0.016863916,
0.024679841,
0.025013525,
0.020162262,
0.032624107,
-0.035524596,
-0.020175096,
-0.011942065,
0.022985749,
-0.032957792,
-0.014014762,
0.024204982,
0.009157081,
-0.020354772,
0.005669433,
-0.01066508,
0.027901182,
0.00070105895,
0.0003950475,
0.016247883,
0.0012336712,
0.0331118,
0.017107762,
-0.0037635795,
-0.025308708,
0.002767338,
0.08552598,
0.015452173,
-0.003242197,
0.02754183,
-0.014848974,
-0.021830685,
0.023332268,
-0.004061971,
-0.02846588,
-0.0019202918,
-0.0319054,
-0.0008879545,
-0.018301329,
0.010357062,
0.021253156,
0.008733558,
-0.024975024,
0.018827522,
-0.016697073,
-0.0018240366,
-0.0060640797,
-0.0033175969,
0.01945639,
0.0036512818,
-0.0022427468,
-0.006176377,
-0.024025306,
-0.017377278,
0.00009510217,
-0.0097795315,
-0.031007018,
0.00251547,
-0.0029293676,
0.021856355,
-0.0031443376,
0.023858463,
0.014399783,
0.0095036,
0.0032341757,
-0.006375305,
-0.01919971,
-0.018955864,
-0.009965625,
-0.009426596,
-0.011403036,
0.0056854757,
0.021933358,
0.0013796584,
-0.0018994366,
-0.020560117,
-0.010973096,
0.0019186876,
-0.021612508,
0.008284367,
-0.015978368,
-0.030390985,
-0.053030215,
-0.024692675,
0.019430723,
-0.023730123,
0.028106527,
0.03241876,
-0.0042448556,
-0.015465007,
0.033933178,
-0.15965535,
0.018570842,
0.0057817306,
-0.009638357,
0.021920525,
-0.0078159245,
0.022844575,
-0.0078095077,
-0.0065710237,
0.005544301,
0.020957973,
0.0068918746,
-0.0113517,
-0.032752447,
0.019854246,
-0.007392402,
0.025719397,
0.038450755,
0.0159527,
0.0039657154,
0.034882896,
-0.006028786,
0.017261771,
-0.031058354,
0.025039194,
0.0042191874,
-0.012006235,
0.038604766,
-0.015285331,
-0.022536557,
-0.02190769,
-0.00451437,
0.03110969,
0.0073538995,
-0.026977133,
0.024474496,
-0.035960954,
-0.0392978,
-0.018301329,
0.012603018,
0.038502093,
0.043481696,
-0.006692947,
0.0006553377,
-0.022883076,
0.009477932,
0.027387822,
-0.017120598,
-0.0012328691,
-0.008387039,
-0.014412616,
-0.014309945,
0.0077710054,
-0.007969933,
-0.004238439,
-0.01627355,
0.012282168,
-0.0011935649,
0.0019443557,
0.01111427,
-0.048409965,
-0.03377917,
0.013745246,
-0.0113966195,
0.005990284,
-0.01993125,
-0.02435899,
-0.016247883,
-0.022587894,
0.013822251,
-0.02276757,
0.040940557,
0.0042448556,
0.0054576714,
0.034651883,
0.028645556,
-0.0054384205,
-0.00073073764,
-0.0026694783,
-0.005897237,
0.015400837,
0.0013612094,
-0.008695056,
-0.02562956,
0.00087191194,
0.019713072,
0.01122336,
0.005877986,
0.01608104,
-0.00539671,
0.0141559355,
-0.019276714,
0.020739794,
-0.017518451,
0.010632995,
0.012173078,
-0.013796583,
-0.01754412,
0.0023357936,
-0.024076642,
-0.0037250775,
-0.011916397,
-0.017133432,
-0.00539671,
0.014643629,
-0.014720634,
-0.030699002,
0.010421233,
0.010645828,
-0.027695838,
-0.0072897295,
-0.004998855,
0.008496128,
-0.020046756,
0.004934685,
-0.0014799242,
0.005942156,
-0.035806946,
-0.008926068,
0.001756658,
0.0662236,
-0.019366553,
-0.008797728,
0.003811707,
-0.0011486458,
-0.0282092,
-0.100772806,
0.0063817217,
0.0054512545,
0.02913325,
-0.004251273,
0.03429253,
-0.010395565,
-0.0002819476,
-0.014399783,
0.022652064,
-0.0024529041,
-0.027464826,
-0.0057817306,
-0.009984876,
0.04556081,
-0.007071551,
0.01808315,
-0.033548158,
0.006144292,
0.033471152,
0.017287439,
-0.02072696,
-0.013231886,
-0.026207091,
-0.007488657,
-0.0135527365,
-0.020906636,
0.008489711,
-0.011505708,
0.01276986,
-0.0004511964,
-0.008431958,
0.00081736734,
-0.0067763682,
-0.02337077,
-0.0030127887,
-0.0050084805,
-0.00827795,
0.028106527,
-0.009991293,
0.007206308,
0.025462717,
0.017197601,
-0.015644683,
0.0047068805,
0.0010066692,
-0.037963063,
0.009946374,
0.0054512545,
-0.0026582486,
-0.007918597,
-0.010613743,
-0.004726132,
-0.015298164,
0.007649082,
-0.024872351,
0.017094929,
0.0034234778,
-0.012346338,
0.02337077,
-0.008650137,
0.01006188,
-0.012108908,
0.0023261681,
0.0020566534,
-0.023768624,
-0.009850118,
-0.031597383,
-0.00402026,
-0.0140917655,
-0.019841412,
0.017659627,
-0.030647665,
-0.024756845,
-0.03611496,
0.017094929,
-0.027233813,
-0.0239483,
-0.006737866,
-0.025308708,
-0.008508963,
-0.013732413,
0.020932304,
-0.01214741,
0.022806073,
0.0053742505,
0.012397674,
-0.0021657427,
-0.0050341487,
-0.025732232,
0.016838249,
0.029723614,
-0.012493929,
-0.022677733,
0.03498557,
0.018198656,
-0.0014751113,
-0.013475732,
0.00956777,
-0.0021641385,
-0.029441267,
0.0003810103,
-0.04807628,
0.009112162,
0.027464826,
-0.014309945,
-0.006673696,
0.002003713,
0.016825415,
-0.011383785,
0.004260898,
0.021997528,
-0.02397397,
0.014220106,
-0.010106799,
0.012006235,
-0.035267916,
-0.024050973,
0.010517488,
0.023255264,
0.036499985,
0.030236976,
-0.0077645886,
0.0035806946,
-0.00302081,
0.041864607,
0.0032887203,
0.0067507,
-0.007090802,
-0.0011895542,
-0.0097795315,
-0.004228813,
0.0024689466,
-0.00048087508,
-0.013360226,
0.020483114,
0.0023855255,
-0.025398547,
0.03293212,
0.015413671,
0.0053742505,
0.029081913,
-0.00634322,
-0.0196489,
0.006497228,
-0.016658572,
-0.009702527,
0.0119998185,
-0.019212544,
0.034651883,
0.003943256,
-0.011569879,
0.026155755,
0.008457626,
-0.01642756,
-0.020521615,
-0.023203928,
0.026900128,
0.000073444746,
0.028234867,
-0.0049058083,
-0.01111427,
0.025719397,
0.011749555,
-0.007578495,
-0.0103827305,
0.028080858,
-0.014258608,
-0.0026951465,
0.012493929,
-0.0026085167,
-0.024718342,
-0.027567498,
0.009984876,
0.010812671,
0.033471152,
-0.010042629,
-0.018352663,
0.008021269,
0.017133432,
-0.019725906,
0.010960262,
0.01614521,
0.01629922,
-0.02384563,
0.026438104,
0.016851082,
-0.006073705,
-0.014528123,
0.0325471,
0.0099078715,
-0.0013844711,
-0.0077325036,
-0.0002552769,
-0.007103636,
0.005922905,
0.0103827305,
0.026271261,
0.005422378,
0.015131323,
0.040837884,
-0.016029704,
-0.010093966,
-0.008816979,
-0.013591238,
-0.040991895,
-0.018519506,
-0.0068405382,
-0.026566444,
-0.033804838,
-0.004738966,
0.0325471,
0.015554845,
0.01330889,
-0.01986708,
-0.0038694602,
0.011152772,
0.019597566,
0.015310999,
0.0017085304,
-0.0029582442,
0.034061518,
0.0014590689,
0.017056426,
-0.0064940196,
0.014451118,
-0.0002957843,
-0.0074116527,
0.017030759,
-0.01773663,
0.036885004,
-0.034189858,
0.018070316,
-0.0019700236,
-0.024602836,
0.011922815,
0.006330386,
-0.025924742,
0.005945365,
0.0038437922,
0.0065902746,
0.067352995,
0.023550447,
-0.0056983097,
0.004017052,
0.005043774,
0.002388734,
0.004860889,
0.0017871388,
-0.003304763,
-0.037424035,
0.008849064,
-0.015400837,
0.030955682,
-0.019353718,
-0.008021269,
0.021484168,
-0.008996655,
0.035165243,
-0.0009890225,
-0.02661778,
0.00823303,
-0.00926617,
0.02442316,
-0.019944083,
-0.014951645,
-0.01496448,
0.03377917,
-0.007501491,
0.003532567,
-0.010042629,
0.0024208191,
0.0011839393,
-0.02120182,
-0.015349501,
0.009323923,
-0.0074180695,
0.000077355115,
-0.026977133,
0.014759135,
-0.016440393,
-0.007527159,
0.0059934924,
-0.011480041,
-0.0043699876,
-0.013873587,
-0.018866025,
0.008977405,
-0.006641611,
-0.019032868
] |
Placental oxidative stress plays a key role in the pathophysiology of placenta-related disorders, most notably preeclampsia (PE) and intrauterine growth restriction (IUGR). Oxidative stress occurs when accumulation of reactive oxygen species (ROS) damages DNA, proteins and lipids, an outcome that is limited by antioxidant enzymes; mitochondrial uncoupling protein 2 (UCP2) may also limit oxidative stress by reducing ROS production. Here we characterized placental antioxidant defenses during normal gestation and following glucocorticoid-induced IUGR. Placentas were collected on Days 16 and 22 | [
-0.02265773,
-0.02686484,
0.007326175,
-0.037982687,
-0.016023947,
0.007214073,
-0.004065335,
0.009884731,
-0.0129774185,
-0.022433525,
0.013676406,
-0.0034619637,
-0.014006116,
0.0076492913,
-0.007207479,
-0.00011168955,
0.040224724,
0.016683368,
-0.0022684105,
0.024451356,
-0.018622069,
0.0101155285,
-0.012627925,
-0.005601787,
0.022618163,
0.0041906247,
0.014085247,
-0.04209748,
0.0024893167,
-0.030597165,
-0.00023697967,
-0.007998785,
-0.010590312,
0.007781176,
-0.01624815,
-0.02869803,
0.020402506,
-0.0020211274,
-0.0076361033,
-0.0037257324,
-0.006683239,
0.021629032,
-0.021022363,
0.010544153,
0.010590312,
0.0117772715,
-0.00092071755,
-0.005311642,
-0.002162903,
0.012377345,
0.02062671,
0.0047247563,
-0.008249365,
-0.0045401184,
-0.002621201,
0.007919654,
-0.008374656,
0.019888159,
0.012014663,
-0.01405887,
-0.0039960956,
0.009574803,
-0.028592525,
0.0080845095,
-0.004223596,
0.021655409,
0.0014597947,
0.034632828,
0.002992126,
-0.0052984534,
0.026574694,
0.020956421,
-0.013597275,
-0.012693867,
-0.002159606,
-0.013175245,
-0.030043252,
-0.009067048,
0.00587215,
0.020046419,
0.014955684,
-0.008790091,
0.0067722606,
0.024068892,
-0.0028355133,
-0.013504956,
-0.015786555,
0.014797422,
-0.002677252,
-0.008532916,
-0.007108566,
0.004160951,
0.024227154,
0.0031388472,
-0.0142962625,
0.009594586,
-0.008282336,
0.022934686,
0.0011605822,
-0.011810242,
-0.0034256957,
0.01027379,
-0.014757858,
-0.01876714,
-0.044075746,
-0.023897441,
-0.00328392,
0.017883517,
0.000996551,
0.007543784,
-0.01144756,
0.026996724,
-0.010155094,
-0.025704257,
0.003768595,
-0.009119802,
0.0289618,
0.008058133,
-0.02956847,
-0.0044280165,
0.013346694,
0.0023277586,
0.028856292,
-0.024992082,
0.003923559,
-0.0018727576,
-0.015456844,
0.009040671,
-0.016656991,
0.0021249864,
-0.014401769,
0.024741502,
0.007939437,
-0.025822952,
-0.020481637,
0.030359775,
-0.0338679,
-0.021787293,
-0.010966183,
-0.027906725,
0.011342053,
0.016169019,
-0.038009066,
-0.0010765059,
-0.012687273,
0.03368326,
0.012937853,
0.026442809,
0.02811774,
0.0122916205,
-0.0030366369,
0.0030201513,
0.012317997,
-0.021866422,
0.00938357,
0.007998785,
0.013689594,
0.023000628,
-0.03974994,
-0.024649182,
0.021009175,
-0.023211643,
-0.0066700503,
0.02567788,
-0.008104293,
0.008565888,
-0.012443287,
0.009001106,
0.038905878,
-0.0013353289,
-0.011348647,
0.012232272,
-0.022921497,
0.034474567,
0.025480054,
0.025809765,
0.0014589705,
0.035371378,
-0.021299321,
-0.032469925,
-0.015338148,
0.011731111,
0.015443656,
0.0011193684,
-0.014942495,
0.015206264,
0.024121646,
0.006416173,
0.018899025,
-0.014533654,
-0.01490293,
0.003114119,
-0.016881196,
-0.02325121,
-0.649504,
-0.007847118,
0.015905252,
0.011388212,
0.015601917,
0.037850805,
0.015377713,
0.0033234854,
-0.007807553,
0.038879503,
-0.010049586,
0.021154247,
-0.0026113098,
0.0076097264,
0.019598013,
-0.037006743,
-0.00549628,
-0.0055589247,
0.008796685,
-0.010352921,
-0.020033231,
-0.011856402,
-0.008058133,
0.009706687,
0.0096011795,
0.047293723,
0.016709745,
-0.029014554,
0.0011292596,
0.049456626,
0.004869829,
0.018041776,
0.0017936269,
0.007326175,
0.05238446,
-0.0074646533,
-0.021154247,
0.041780956,
0.005433635,
0.041728202,
-0.016485542,
-0.010003427,
0.010036398,
-0.011473937,
-0.010985965,
0.029014554,
0.02938383,
-0.014309451,
0.010676037,
-0.0043027266,
-0.0012801023,
0.003527906,
0.009317628,
0.0136368405,
0.019558446,
0.0061952667,
0.02602078,
-0.017725255,
0.012054228,
0.015944816,
0.011335459,
0.016380034,
-0.0047676186,
-0.035318624,
0.00015001843,
0.020732218,
-0.03629457,
0.010122123,
0.018331923,
-0.0015933276,
0.018173661,
0.026706578,
0.008031756,
-0.0044445023,
0.018331923,
0.009634151,
0.026113098,
0.027141796,
-0.015232641,
0.042704146,
0.0016477299,
0.00013878765,
-0.0314676,
0.023923818,
0.018213227,
-0.003923559,
-0.018819895,
0.0010047938,
0.006996464,
-0.024794254,
0.011731111,
0.0030300426,
-0.02180048,
-0.035608772,
-0.0143226385,
0.011698141,
-0.032311663,
0.012482853,
0.019927723,
0.0027679226,
-0.022182945,
0.0035147176,
-0.036057178,
0.029120062,
0.02711542,
0.037428774,
-0.043653715,
0.0017688987,
0.038879503,
-0.0063700136,
-0.004807184,
0.015905252,
-0.00078636035,
-0.00947589,
0.023383092,
-0.01893859,
-0.0080845095,
0.006482115,
-0.0321534,
-0.025058024,
0.012074011,
-0.0080845095,
-0.0019584824,
-0.030702673,
-0.016868006,
-0.001475456,
0.008473569,
-0.0079130605,
0.0032460033,
-0.021325698,
0.0063963905,
-0.0024612914,
0.018305546,
-0.015048003,
0.018991344,
0.008579076,
0.013142274,
-0.0044774734,
0.023409469,
-0.033656884,
-0.023699615,
-0.012845535,
-0.006653565,
0.0006404633,
-0.02661426,
-0.013241188,
-0.0038773995,
0.0042104074,
0.022235699,
-0.00059471594,
-0.011909155,
-0.017197717,
-0.021681786,
0.009937485,
-0.0013592329,
-0.0027267088,
-0.012271837,
-0.02769571,
-0.00005630843,
-0.0003334201,
0.00040945964,
0.027431943,
-0.02054758,
0.004876423,
-0.016116265,
-0.020995986,
-0.02020468,
0.010432051,
-0.02888267,
-0.0074646533,
-0.019980477,
-0.013109303,
-0.0032591918,
0.014164378,
0.00150513,
0.01860888,
-0.010504588,
0.0016518513,
-0.02350179,
0.007754799,
0.011111256,
-0.008625235,
-0.017606558,
-0.0058523673,
0.0022469794,
0.017461486,
0.0095022665,
0.0015850848,
0.003949936,
0.036584716,
-0.007141537,
0.03803544,
-0.016234962,
0.017342791,
-0.0054600113,
-0.04621227,
-0.01809453,
0.002673955,
-0.008097698,
0.035397757,
0.027511073,
-0.026983535,
0.00016794646,
-0.019809028,
0.035371378,
-0.0026409838,
-0.00043810328,
-0.024095269,
0.020481637,
-0.0034817464,
-0.012772998,
0.008645019,
0.0047280537,
-0.016129455,
-0.016525107,
0.0062216436,
-0.002751437,
0.001856272,
-0.0023838093,
-0.022459902,
-0.0049324743,
-0.01355771,
0.03687486,
0.003061365,
-0.024002949,
0.0030234484,
-0.004065335,
0.0051303008,
0.019347433,
-0.0069239275,
0.017052645,
-0.010504588,
0.0146391615,
-0.013056549,
0.002777814,
0.009831977,
-0.003066311,
-0.016999891,
0.04489343,
0.0032196264,
-0.006000737,
-0.009733064,
0.042229366,
0.0005357801,
-0.003620225,
-0.019439751,
0.024398603,
0.0033927246,
-0.022341207,
0.008104293,
-0.012390533,
-0.0026409838,
-0.01937381,
0.001475456,
-0.007939437,
0.0040686317,
0.007510813,
0.0070624063,
0.028671654,
0.0069305217,
0.011994881,
-0.0034388842,
-0.010438645,
0.0065810285,
0.023514977,
0.015443656,
0.011183792,
-0.014098436,
0.006238129,
0.0070624063,
-0.016129455,
0.0077482047,
-0.010517776,
-0.0036531962,
0.012252055,
0.023778746,
0.011836619,
0.016485542,
0.02922557,
-0.0068777683,
0.004536821,
-0.013926986,
0.016854819,
0.036505584,
-0.021866422,
-0.010075963,
-0.031098327,
-0.0132939415,
-0.0010913429,
0.030412529,
0.004404937,
0.020587144,
-0.0007076419,
0.0006495304,
-0.006531572,
-0.020745406,
0.021299321,
-0.033551376,
0.01330713,
-0.017197717,
0.01241691,
0.0023953493,
-0.01057053,
0.013069738,
0.032179777,
0.015865685,
0.009482483,
0.0022057656,
-0.0004974512,
-0.018292358,
-0.009924296,
-0.01423032,
0.0073063923,
0.011698141,
0.0006416997,
0.006238129,
0.011236546,
-0.022156568,
0.030412529,
0.008005379,
-0.002992126,
-0.0367166,
-0.010517776,
-0.022380771,
0.02525585,
0.042202987,
-0.0002936487,
0.040514868,
0.026469186,
0.007458059,
0.006742587,
-0.034975726,
0.012383939,
0.0070360294,
-0.014744669,
-0.027616581,
0.02988499,
-0.010887052,
0.016063511,
0.0030564195,
0.018120907,
-0.032443546,
-0.02206425,
-0.003893885,
-0.00037133685,
-0.012891694,
0.018054966,
0.046080388,
0.011414589,
-0.0012322942,
0.024781067,
0.0021085008,
-0.002296436,
-0.007398711,
-0.01928149,
0.017052645,
-0.014441335,
0.008572482,
0.0052489964,
-0.0035707685,
0.022473091,
-0.020442072,
0.041306175,
0.03149398,
0.012918071,
0.02164222,
-0.000010651206,
-0.0034520726,
-0.0011498666,
-0.012344374,
0.0037817834,
0.010451834,
-0.011605822,
-0.039301533,
0.01928149,
-0.003864211,
0.00083952624,
-0.021272944,
0.015707424,
-0.024464544,
0.0025536104,
-0.0002507863,
-0.0049159885,
-0.023449035,
-0.006165593,
0.011342053,
0.0046027633,
-0.01624815,
-0.0011770678,
-0.0066107023,
-0.0023096243,
0.0026195527,
-0.03307659,
-0.0022618163,
-0.0011070041,
-0.0002936487,
-0.030016875,
0.016406411,
0.03183688,
0.016063511,
0.009535237,
-0.020112362,
0.022117004,
0.0008374655,
-0.011065096,
-0.015971193,
0.00028149062,
-0.039433416,
-0.0077943644,
0.0038444283,
0.00875712,
-0.011223357,
-0.0154964095,
-0.0006029587,
-0.00088362506,
-0.013030172,
-0.017158153,
-0.006963493,
0.0040521463,
0.0040587406,
0.0024283202,
0.021483958,
-0.016643804,
-0.003254246,
-0.0033482136,
-0.0367166,
-0.011645387,
-0.019558446,
-0.0157338,
0.00034784494,
-0.01052437,
-0.016116265,
-0.0035377974,
-0.00029612155,
0.037006743,
-0.0107749505,
0.010491399,
0.0061557014,
0.021708163,
0.028302379,
-0.010662849,
0.039591677,
0.0043752627,
0.0049126917,
-0.0052292137,
-0.0043686684,
0.032575432,
0.0022008198,
0.0020260732,
0.030623542,
-0.010465022,
-0.023752369,
-0.014876553,
0.00036659723,
0.025242662,
0.027326435,
-0.0081570465,
-0.021853235,
-0.028012233,
-0.0012504284,
-0.013023579,
0.013926986,
0.00033032906,
-0.01072879,
-0.009390165,
0.0044774734,
-0.006531572,
-0.019637577,
0.06493985,
-0.03315572,
-0.0013320318,
0.009462701,
-0.0035048262,
0.011684952,
-0.005835882,
-0.015166699,
-0.029436585,
0.008018567,
-0.030412529,
-0.030122383,
-0.008282336,
-0.017487863,
0.032707315,
0.018490184,
0.04033023,
-0.009983644,
0.009660528,
0.022446714,
0.004464285,
0.0038246457,
-0.00044634606,
0.007326175,
-0.022024684,
0.016604237,
-0.014665538,
-0.00015960065,
-0.0074382764,
-0.02137845,
-0.0046753,
0.015549163,
-0.03410529,
-0.013465391,
0.003616928,
-0.03695399,
-0.020046419,
-0.00018329862,
-0.006871174,
-0.008097698,
-0.046133142,
-0.014032493,
0.0254273,
0.011177197,
0.009396759,
-0.01843743,
0.02433266,
-0.031863257,
0.038378343,
0.0017936269,
0.01726366,
0.0092582805,
-0.024847008,
0.01524583,
-0.0021958742,
0.01082111,
0.004019175,
0.036004424,
0.0068250145,
-0.009607774,
-0.004569792,
0.011823431,
-0.006327151,
-0.008295525,
0.012984013,
-0.02331715,
0.005077547,
0.002185983,
0.0054237433,
-0.02980586,
-0.011084879,
-0.006376608,
-0.021009175,
0.013966551,
-0.007985597,
0.001118544,
0.011032125,
0.0005032212,
0.008473569,
-0.022552222,
0.015905252,
0.010075963,
0.011124444,
-0.01987497,
-0.0067986376,
0.02904093,
0.0014317693,
0.027326435,
0.005206134,
-0.019439751,
-0.022947874,
-0.0037850805,
-0.0015545866,
-0.025466865,
-0.020679465,
0.017448299,
0.014138001,
-0.004441205,
-0.0050940323,
-0.010643066,
-0.005502874,
-0.0007706991,
-0.027748464,
-0.0022304938,
-0.010234225,
-0.0068843625,
-0.013089521,
0.0051533803,
-0.010550747,
0.017158153,
-0.0021991713,
-0.0043126177,
-0.010893647,
-0.036426455,
0.01423032,
-0.0032311662,
0.021035552,
0.010339732,
0.0026426325,
0.00061120145,
0.00094132446,
0.0023953493,
0.026469186,
-0.0056446497,
0.010135312,
0.038536604,
0.00015712783,
-0.00858567,
0.027220927,
0.01524583,
0.00549628,
0.0086713955,
-0.008565888,
-0.01574699,
-0.018516561,
-0.011012342,
0.0073195808,
-0.0008053187,
-0.031625863,
-0.008176829,
-0.017355978,
0.003771892,
-0.03645283,
-0.020046419,
0.0052094315,
-0.016854819,
0.009944079,
0.011684952,
-0.005572113,
0.009766035,
-0.01718453,
-0.0075042187,
-0.023686428,
-0.0039400444,
-0.015338148,
0.025361357,
0.008348279,
0.0041807336,
-0.008249365,
0.005479794,
-0.024952516,
-0.014098436,
0.014612785,
-0.0041049,
-0.036822107,
0.007622915,
-0.0065018977,
-0.009818789,
-0.014731481,
-0.018054966,
0.017685689,
-0.006689833,
0.005410555,
-0.026917594,
-0.006050194,
0.01903091,
0.0028058393,
0.018859461,
0.018213227,
-0.038536604,
-0.0034817464,
-0.0062150494,
-0.0053050476,
0.027985856,
-0.0036729788,
0.009291251,
-0.003943342,
0.0067063184,
-0.013333507,
-0.002537125,
-0.012502635,
-0.010385891,
-0.015061191,
0.01970352,
0.0019485911,
-0.014124813,
-0.020903667,
0.00090588053,
0.008137263,
0.011869591,
0.0029525605,
0.0076624798,
0.011084879,
-0.013584087,
-0.019439751,
-0.011968504,
-0.014217132,
0.021075116,
0.015166699,
-0.034738336,
0.0014993601,
0.007332769,
-0.023290774,
-0.0011993232,
-0.01296423,
0.0054369317,
0.0049390686,
0.0148369875,
0.019175982,
0.002659118,
0.009884731,
0.024029326,
-0.012179518,
0.0007892453,
-0.0012430099,
-0.010122123,
0.036848485,
-0.0057963165,
-0.043416325,
-0.02053439,
0.03940704,
0.010590312,
-0.0009784169,
0.023646861,
0.0032822713,
0.016907573,
-0.023000628,
0.0056710267,
0.016010758,
0.014375392,
0.020587144,
-0.022591786,
-0.025862519,
0.016010758,
0.0076361033,
0.0019106743,
-0.0028322162,
0.016380034,
-0.004691785,
0.0025766902,
-0.0039004793,
0.0039400444,
0.010985965,
-0.006142513,
-0.005565519,
0.013471985,
-0.021483958,
0.0010674389,
0.03241717,
-0.007992191,
-0.0012224029,
-0.00091659615,
-0.00589523,
-0.0013872584,
0.018002212,
-0.003771892,
-0.035318624,
-0.001900783,
0.016828442,
-0.03479109,
-0.022881933,
-0.011895967,
-0.006778855,
-0.013168651,
0.019901346,
-0.005410555,
0.000038328886,
0.0022140082,
-0.0009800654,
-0.008539511,
-0.0021958742,
-0.01283894,
-0.005512765,
-0.008302119,
-0.025414111,
-0.0021052037,
-0.013755537,
0.008539511,
-0.030201513,
-0.025585562,
-0.007049218,
0.029251946,
0.17187166,
0.0034949349,
0.0009850111,
0.00875712,
0.009779223,
-0.0042137047,
0.011500314,
-0.01893859,
-0.0039565302,
0.005984252,
0.017316414,
0.0047511333,
-0.0024448058,
0.0027827595,
-0.0019766164,
0.0045829806,
-0.030913688,
0.008579076,
-0.017896704,
-0.004807184,
0.02290831,
-0.019413374,
0.017065832,
-0.005868853,
0.03782443,
-0.0076163206,
-0.012746621,
0.0035971452,
0.019268302,
0.011895967,
0.0033168911,
0.020771783,
-0.006637079,
0.019321056,
0.009897919,
-0.019215548,
0.010280384,
-0.013155462,
0.0015496409,
-0.032865576,
-0.0057039973,
0.025532808,
-0.006089759,
0.022921497,
-0.024912952,
0.018806707,
-0.009344005,
-0.01759337,
-0.01423032,
0.005047873,
-0.05027431,
0.02391063,
-0.008862628,
0.02533498,
-0.006937116,
0.0065546515,
0.010985965,
0.0128785055,
-0.015707424,
-0.0008737337,
-0.03587254,
-0.000116326104,
-0.026324114,
0.007873495,
-0.018411053,
0.025822952,
-0.010583718,
-0.013584087,
-0.026033968,
0.0072272616,
0.009403354,
0.001371597,
0.016353657,
0.0022733563,
-0.017830763,
-0.018265981,
0.024807444,
-0.0078009586,
0.012390533,
-0.007484436,
-0.0019683738,
0.01191575,
-0.030834557,
-0.009627556,
-0.026390055,
-0.04808503,
0.015641483,
0.025585562,
-0.020231057,
-0.004919286,
0.00072495174,
-0.0013757185,
-0.007141537,
-0.011816837,
-0.009489078,
-0.001763953,
-0.009574803,
0.010676037,
-0.012397127,
-0.0047511333,
-0.019729897,
0.07390798,
0.0027827595,
0.0073393635,
-0.022262076,
0.015166699,
0.008987918,
0.031203834,
-0.00010633175,
0.005595193,
-0.0072536385,
-0.005539142,
-0.010161689,
-0.021233378,
-0.015166699,
0.01634047,
0.0012529012,
-0.024213964,
0.025361357,
-0.022697294,
0.01540409,
-0.021866422,
0.015061191,
-0.009403354,
-0.0037224353,
-0.01634047,
-0.036663845,
0.011678358,
-0.023000628,
-0.016868006,
0.0037949719,
-0.024794254,
0.0029937744,
0.025770199,
0.0028519987,
0.009891326,
0.0125422,
0.002218954,
0.012957636,
0.023897441,
-0.020521203,
0.008816468,
0.012423504,
-0.0031388472,
0.0050379816,
-0.012410316,
0.011394807,
-0.010537558,
-0.008407626,
-0.014085247,
-0.021998307,
-0.011717923,
0.0050643585,
-0.016169019,
0.014085247,
-0.03787718,
-0.012126765,
-0.036663845,
-0.0066139996,
0.009825383,
-0.009423136,
0.036268193,
0.0049093943,
-0.023290774,
-0.0070162467,
-0.021563089,
-0.16585775,
0.009403354,
0.019057287,
-0.025374547,
0.014850176,
0.009238497,
0.018964967,
0.013373071,
-0.024635995,
0.00050445757,
0.03518674,
0.0058589615,
-0.03252268,
0.0032262206,
-0.010042992,
0.019584823,
-0.0100166155,
0.043917485,
0.020362942,
0.011164009,
0.017527428,
-0.02694397,
0.0059809545,
-0.016630614,
0.013274158,
0.0014977115,
-0.0017721958,
0.003715841,
-0.0026805492,
-0.010214441,
-0.0331821,
0.019439751,
0.029120062,
0.030280644,
-0.006046897,
-0.01136843,
0.018213227,
-0.014678727,
-0.0009907811,
0.015839309,
0.015944816,
0.002570096,
-0.0009998481,
-0.0012174572,
-0.0059479834,
0.048955467,
-0.0054270406,
0.0062249405,
0.034474567,
0.0075305956,
0.020178303,
0.011869591,
-0.0012322942,
0.017566994,
0.00574686,
0.009020888,
-0.0076822625,
0.011783865,
-0.001900783,
-0.024847008,
-0.009911108,
-0.02846064,
0.033736013,
-0.0051303008,
0.017237283,
-0.018819895,
0.005235808,
0.024345849,
-0.03294471,
-0.007029435,
-0.009587991,
-0.018068153,
0.011823431,
-0.010972776,
0.027669333,
-0.010933211,
-0.008018567,
0.032707315,
-0.0081570465,
0.012027851,
-0.0024019436,
0.007998785,
-0.016709745,
-0.01649873,
-0.021866422,
0.00450385,
0.018226415,
0.013584087,
-0.011183792,
-0.008354872,
0.027379189,
-0.039565302,
0.0057270774,
-0.036083553,
-0.0029146438,
0.0018183553,
-0.0015958005,
0.017197717,
-0.01465235,
-0.0070755947,
0.011599228,
-0.0119750975,
-0.042651396,
0.010999153,
0.02021787,
-0.0014111624,
0.0026789005,
-0.013715971,
0.061247084,
-0.016314093,
-0.00045829808,
-0.00059512805,
-0.0051764604,
0.040805012,
-0.016182208,
0.028856292,
0.03502848,
-0.0059479834,
0.012845535,
-0.04842793,
0.047451984,
0.0041114944,
0.011203574,
0.023462223,
-0.006132622,
-0.027141796,
-0.1342055,
-0.03450094,
-0.00017402551,
0.0107749505,
0.00083581696,
0.0015875577,
-0.006653565,
0.030623542,
0.0057270774,
0.03130934,
-0.0094297305,
-0.015338148,
0.0030564195,
0.0022881932,
0.026891217,
-0.020059608,
-0.0069107395,
-0.016023947,
-0.019637577,
0.03225891,
-0.011355242,
-0.022024684,
0.0012454827,
-0.0041477624,
0.006577731,
-0.011440966,
-0.019835405,
-0.0011144227,
-0.00060213445,
0.00047519576,
0.019255113,
0.00656784,
0.02777484,
-0.01624815,
-0.009587991,
-0.020930044,
0.009080237,
-0.026627447,
0.02922557,
-0.007484436,
-0.0003406325,
-0.017791197,
0.029832236,
0.012568577,
-0.0031042276,
0.0015817877,
-0.011190386,
0.0019865078,
0.011909155,
-0.037191384,
-0.041016027,
0.0076097264,
-0.0011515152,
-0.008328496,
0.03049166,
-0.008466975,
0.034210797,
0.028144117,
-0.008321902,
0.0094297305,
0.01102553,
-0.0016600941,
-0.03663747,
0.008262553,
0.027959479,
-0.027036289,
-0.021022363,
-0.030280644,
0.0010509533,
-0.021497147,
0.0031784126,
-0.011302488,
0.0024316174,
-0.0061589987,
-0.01271365,
0.007207479,
-0.025123967,
-0.0063700136,
0.0059380922,
-0.02391063,
-0.00177879,
-0.015140322,
0.021233378,
-0.009284657,
0.020692652,
0.019967288,
-0.0022057656,
0.0010674389,
0.0016361901,
0.00063551764,
-0.030860934,
0.03115108,
0.02087729,
-0.035397757,
-0.0164196,
0.0013213162,
-0.018476995,
-0.017369168,
0.024148023,
0.0033004056,
-0.01810772,
-0.005169866,
-0.039855447,
0.032206155,
0.013313724,
0.002677252,
-0.02046845,
0.014744669,
0.0002715993,
-0.00075833494,
0.00985176,
-0.0016930652,
-0.024016138,
0.0012446584,
0.0010080909,
-0.00475443,
-0.0088428445,
-0.013715971,
0.027247304,
0.014560031,
0.016063511,
-0.004718162,
-0.022024684,
0.003554283,
-0.008124075,
0.014705104,
0.002903104,
0.0000975738,
-0.010847487,
0.017079022,
-0.016300904,
-0.010709008,
0.0013691243,
-0.036822107,
-0.019663954,
0.013689594,
-0.016300904,
-0.032047894,
-0.0013691243,
0.027062666,
0.019400187,
0.020705841,
-0.022301642,
-0.024240341,
-0.002950912,
-0.0020161818,
0.0062315348,
-0.01465235,
-0.027563827,
-0.0013213162,
-0.004098306,
-0.0076624798,
0.035767034,
0.012403722,
0.011572851,
-0.024477733,
-0.008427409,
0.002847053,
-0.009337411,
0.0060567884,
-0.018556125,
-0.023185266,
0.026746143,
-0.0027893537,
0.012799375,
0.003926856,
0.02769571,
-0.008921975,
0.001680701,
-0.010049586,
-0.0009561614,
-0.0180154,
-0.013597275,
-0.007622915,
0.003117416,
0.0075569726,
0.0042367843,
-0.018371489,
0.0057369685,
0.014309451,
-0.004108197,
0.020244246,
0.022407148,
0.011671764,
-0.017065832,
0.004464285,
0.038853124,
-0.007181102,
-0.0060436,
0.027062666,
0.016182208,
0.016089888,
-0.009766035,
0.023000628,
0.0037290296,
-0.0072008846,
0.020138739,
0.004962148,
0.0043291035,
-0.014955684,
0.0073195808,
0.030043252,
-0.008295525,
-0.003206438,
-0.0016172316,
-0.02298744,
0.004371966,
0.0053347214,
-0.007946031,
-0.037033122,
-0.016815253,
0.0078009586,
0.0076558855,
0.0049159885,
0.0012710353,
0.004737945,
-0.007431682,
0.017830763,
-0.0011844862,
0.0012397128,
0.014388581,
0.02711542,
0.013399448,
-0.0022601679,
-0.018226415,
-0.0072272616,
0.03434268,
0.00008433385,
0.03341949,
-0.011882779,
0.035054855,
-0.011862996,
0.041411683,
-0.011572851,
-0.04739923,
-0.019123228,
0.021866422,
-0.023356715,
-0.0026393353,
0.026482375,
0.0030778507,
0.08931207,
-0.0021068524,
-0.024570052,
-0.010669443,
-0.012720244,
0.028302379,
-0.00010890761,
0.019083664,
0.008321902,
-0.022591786,
0.01970352,
-0.011731111,
0.027247304,
-0.010385891,
-0.014124813,
0.0025750417,
0.004655517,
-0.0014202294,
-0.0076888567,
-0.018054966,
0.033788767,
-0.0059545776,
0.007781176,
0.033656884,
-0.044735167,
-0.022552222,
0.030966442,
-0.005990846,
0.0051237065,
-0.022829179,
0.0011861348,
0.008921975,
-0.03175775,
-0.00686458,
0.015232641,
-0.019967288,
-0.010352921,
-0.005136895,
0.006551354,
-0.0040785233,
-0.009700093,
-0.0007834754,
-0.046845317,
-0.028328756,
-0.008869221,
-0.020099172,
-0.017909894,
-0.001885946,
-0.026640637
] |
Bisphosphonates are currently used for the treatment of bone metastases, and emerging data suggest that they may also have antitumor properties. Preclinical studies have demonstrated that zoledronic acid can inhibit angiogenesis, invasion and adhesion of tumor cells, and overall tumor progression, and emerging evidence suggests that the use of these agents may impede the development of skeletal metastases. In a recent clinical study in patients with metastatic bone disease, basal levels of vascular endothelial growth factor, a factor essential for angiogenesis, were significantly reduced in patients receiving zoledronic acid, suggesting that zoledronic acid may have clinically | [
-0.010710829,
-0.02178606,
0.018246152,
-0.031156408,
-0.01006011,
0.04294743,
-0.03711699,
-0.020822996,
-0.03261402,
-0.009376856,
0.01648921,
0.001831773,
0.016632369,
-0.01741323,
-0.018076964,
-0.00059093384,
0.041984368,
0.015877536,
-0.014380882,
0.013821264,
0.0023246924,
0.010528628,
0.006435607,
-0.015786434,
-0.008940874,
0.008960396,
0.029750856,
-0.03318665,
-0.0032080428,
-0.0037806754,
-0.00409302,
0.0018643088,
-0.0035626846,
-0.005827185,
0.0030827795,
0.010125182,
0.009838866,
-0.00784116,
0.0057848888,
0.004568045,
0.008094939,
-0.025573242,
0.019378401,
-0.02220252,
-0.013046909,
-0.004132063,
-0.0044053653,
-0.021773046,
-0.017790647,
0.003183641,
0.008173026,
0.008713122,
-0.0007214843,
0.0062631667,
0.015812462,
-0.027408268,
0.007932261,
0.037585508,
-0.000044736906,
-0.014875428,
-0.023790274,
-0.0044736904,
-0.03815814,
0.018428352,
0.0047339783,
-0.0009825851,
0.0033381865,
0.014654184,
-0.0018464142,
0.00018342132,
0.023699174,
0.026939752,
-0.0041483315,
-0.0061135017,
0.023673143,
-0.021603858,
-0.0257164,
-0.004831586,
0.008543936,
0.002518281,
0.026705492,
-0.011244418,
-0.012610927,
0.022762138,
0.025365012,
0.038886946,
-0.010307383,
0.0023328264,
-0.0099885315,
0.0074897716,
0.013352746,
0.015083658,
0.01218796,
0.030037172,
-0.0124482475,
0.014471983,
0.0072359913,
0.03230167,
-0.011368055,
-0.01991199,
0.015591218,
-0.000009360435,
-0.01514873,
-0.020757925,
-0.022267591,
-0.006773981,
-0.0029965593,
0.013717148,
0.023412857,
-0.009760779,
-0.031026265,
0.06262516,
0.028735735,
-0.0035789525,
0.042556997,
-0.011094753,
0.016671412,
0.014341839,
0.011641356,
0.0099885315,
-0.00038982113,
0.005628716,
0.0053619216,
-0.020718882,
0.0340456,
-0.014745284,
-0.009780301,
-0.012741071,
0.0019570363,
0.0024532094,
0.0060484298,
0.016124807,
-0.013665091,
0.01248729,
-0.027694585,
0.020419551,
-0.010619728,
-0.027486356,
-0.029933058,
-0.05710707,
0.010196761,
0.020510651,
-0.008986425,
-0.024089605,
-0.008029868,
0.013925379,
0.01845438,
-0.0013510545,
0.0039401012,
-0.0055376156,
-0.0030274685,
-0.0317811,
0.0039466084,
-0.0097672865,
-0.022059362,
-0.028527506,
0.007509293,
0.021005198,
-0.01753036,
-0.0059996257,
-0.0043695755,
-0.015369974,
0.0012575138,
0.006198095,
-0.0000846951,
0.016111793,
0.0145110255,
-0.008817238,
-0.024571136,
-0.03441,
-0.00137627,
0.037949912,
-0.018441366,
0.009995039,
-0.025677357,
-0.0036245028,
0.0019781846,
-0.008856281,
-0.01940443,
-0.0127996355,
0.008537428,
0.008752165,
0.027538413,
0.009188147,
-0.014302796,
0.010021067,
0.011556763,
-0.021812089,
-0.0013046908,
-0.050053276,
-0.0044118725,
0.028189132,
0.0068325456,
-0.0044118725,
-0.6346849,
-0.033108566,
-0.0015161744,
-0.01898797,
0.027304154,
0.004070245,
0.021356586,
-0.024935538,
-0.002983545,
-0.0064811576,
-0.004548523,
0.016853612,
-0.0008735898,
-0.022436779,
-0.01431581,
-0.021499744,
-0.017400216,
-0.030974207,
0.018766725,
-0.0106913075,
-0.027460327,
0.008270634,
-0.018636582,
0.017699547,
0.021655917,
0.01917017,
0.019990077,
-0.011738964,
0.015448061,
0.044431068,
-0.025950659,
0.022033334,
0.008986425,
0.0073791496,
0.040761016,
0.0058597215,
0.002406032,
0.0065039326,
0.007684987,
0.02407659,
0.0023490943,
0.00019775746,
0.027043866,
-0.007190441,
-0.03131258,
0.012083845,
0.035373066,
0.024506064,
-0.0031771339,
0.010958102,
0.0011330638,
0.012220496,
-0.024180705,
-0.019833904,
0.017165957,
0.0129297795,
0.018740697,
-0.022306634,
0.011686907,
0.0191051,
0.012129395,
-0.0040995274,
0.0061688125,
-0.050651938,
-0.020458594,
0.029178225,
-0.008609007,
0.013495904,
0.008264126,
-0.005622209,
0.038106084,
-0.0030372292,
0.03136464,
-0.007092833,
0.041463792,
0.01523983,
0.004574552,
0.026223961,
-0.015617248,
-0.011342026,
0.0059378077,
0.008257619,
-0.035347037,
0.0024759844,
0.028683677,
0.026119847,
-0.02863162,
-0.003647278,
0.04068293,
0.006285942,
0.021681946,
0.011667385,
-0.025508171,
-0.03482646,
0.000880097,
0.01723103,
0.02092711,
0.015096673,
0.024141662,
-0.009969009,
-0.034956604,
0.009044989,
0.010853987,
0.004096274,
-0.00922719,
0.000663733,
-0.033967514,
-0.0053781895,
0.022163477,
-0.03243182,
0.0024938793,
-0.02300941,
0.008146998,
-0.010450541,
0.0061395303,
-0.024219748,
-0.0024190466,
-0.0037676608,
-0.018675625,
-0.03154684,
0.0059768506,
0.010593699,
-0.008075418,
0.03053172,
0.0040181875,
-0.010418005,
0.016580312,
-0.0049096723,
-0.022228548,
-0.022423765,
-0.008960396,
-0.003725364,
0.010242311,
-0.014263753,
0.014133609,
0.016749498,
0.0078021167,
0.0021245964,
0.0010948341,
-0.027746642,
-0.012500305,
-0.01803792,
0.010112167,
-0.005869482,
-0.0072555128,
-0.012376669,
-0.0036798138,
0.023699174,
-0.008732644,
0.03610187,
-0.0056905346,
0.00077964226,
-0.0011672266,
0.020146249,
0.023660129,
-0.0018854572,
0.0022612473,
-0.015461075,
-0.007405178,
-0.006806517,
-0.005270821,
-0.022462808,
-0.0127540855,
-0.013899351,
0.0067089093,
-0.044092696,
0.016189879,
0.004320772,
-0.004343547,
-0.02990703,
-0.0019472755,
-0.023595057,
-0.02428482,
0.0051536914,
-0.009793315,
0.00634776,
-0.014055522,
0.0063152243,
-0.008355227,
0.003400005,
0.010138196,
-0.012851693,
-0.012298582,
0.0059931185,
0.044118725,
0.007990825,
0.026913723,
0.017205,
0.0029412482,
0.020471608,
-0.0060191476,
0.045316044,
-0.012025281,
-0.0032991434,
0.012662984,
-0.05086017,
-0.008088432,
0.0037286177,
-0.005453022,
0.007743552,
0.04190628,
-0.007990825,
0.02738224,
0.018089978,
0.0145110255,
0.0021636395,
-0.0077760876,
-0.006608048,
0.05078208,
0.007977811,
0.0032454592,
-0.00049129257,
-0.025612285,
0.012129395,
-0.00037579003,
0.027538413,
0.002807851,
-0.0065202005,
0.0004302877,
-0.0062664207,
-0.0027476593,
0.0051732133,
0.01991199,
-0.010710829,
-0.015448061,
-0.006975704,
0.019144142,
0.025482142,
0.001539763,
-0.005176467,
-0.008296663,
0.035555266,
-0.013990451,
0.016033707,
0.016385095,
0.008361734,
0.022723095,
-0.0065527367,
0.027538413,
-0.0059768506,
-0.008010346,
0.017699547,
0.02107027,
0.00927274,
0.02086204,
0.026145875,
0.030141287,
0.011914658,
0.0011712936,
0.03529498,
-0.0095915925,
-0.0035334022,
-0.019625675,
-0.012344132,
0.021057256,
-0.018584525,
0.017309116,
0.030375546,
0.04836141,
0.011465662,
0.037273165,
0.007691494,
-0.01568232,
-0.008088432,
0.004805557,
0.015044615,
0.020250363,
0.005687281,
-0.011543749,
-0.006871589,
-0.01084748,
-0.020484623,
0.013626048,
-0.02044558,
0.018662611,
0.000479905,
-0.011068724,
0.014758299,
0.0034195264,
0.042036425,
-0.0028338796,
-0.049220357,
0.023295727,
0.017920792,
0.0016056482,
-0.017608447,
-0.0191962,
-0.008049389,
0.01431581,
0.023803288,
0.017959835,
0.001966797,
0.009975517,
0.015200787,
-0.02035448,
-0.03487852,
0.0070733116,
-0.011485184,
0.02824119,
0.007639437,
-0.008875802,
-0.00069098186,
-0.00684556,
-0.013521933,
0.0529685,
-0.017543374,
0.002415793,
-0.01244174,
-0.022983382,
-0.029022051,
-0.0022270845,
0.0031559854,
-0.0033072776,
-0.010971116,
0.0041548386,
0.019144142,
0.008355227,
0.0022889029,
0.01535696,
-0.041359678,
0.008146998,
-0.00070236943,
-0.005117902,
0.021304527,
0.022215534,
-0.0029867985,
0.014576097,
0.013573991,
0.020315437,
0.026679464,
-0.0041223024,
-0.012838678,
0.013925379,
0.0063575213,
0.012773607,
0.00513417,
-0.0055864197,
-0.004086513,
0.0011078485,
0.030687891,
-0.025638314,
-0.055337112,
0.023556015,
-0.029022051,
0.0039628763,
0.00025866067,
0.050912227,
0.012168438,
0.0429214,
-0.0054009645,
0.01010566,
0.029568655,
0.010919059,
-0.023399843,
-0.025664343,
0.0011891883,
-0.01248729,
0.008062404,
-0.0009077525,
-0.030974207,
-0.011094753,
-0.0041223024,
-0.00044167528,
0.0074832644,
0.0029396215,
0.030323489,
0.015786434,
0.0047795284,
-0.004161346,
-0.015721362,
0.021864146,
-0.00044086188,
0.012493798,
-0.00034203398,
0.023503957,
-0.0071253693,
0.012780114,
-0.008374749,
-0.000863829,
0.00409302,
-0.0042264177,
-0.0048185717,
-0.023178598,
0.012090352,
0.0036505316,
-0.01637208,
0.020198306,
-0.01723103,
0.021499744,
-0.0015788061,
-0.03568541,
-0.027304154,
-0.0032275645,
0.008212069,
-0.010496092,
-0.02300941,
-0.005417233,
-0.018818783,
0.022684053,
0.016580312,
0.008726137,
-0.00067512057,
-0.01098413,
0.021616872,
0.0116804,
0.009890923,
-0.0040409626,
-0.0469038,
-0.0069496753,
-0.010372455,
-0.019027013,
0.0050170408,
-0.0023637353,
-0.0019863187,
0.020237349,
0.005742592,
0.021135341,
-0.016020693,
0.004766514,
0.01114681,
0.010183747,
0.005404218,
0.0021213428,
-0.0074246996,
0.0031608657,
0.014615141,
-0.012532841,
-0.035112776,
-0.009838866,
-0.006237138,
-0.0023702427,
0.004825079,
-0.00083861366,
-0.011602313,
-0.0038652688,
-0.019040028,
-0.010073124,
-0.024089605,
0.003429287,
0.0027850757,
-0.02211142,
0.010170733,
0.0016389976,
0.0072815414,
0.0078802025,
0.022345679,
0.021031227,
-0.042635087,
-0.017296102,
0.0018740697,
-0.0005746659,
-0.0062501524,
-0.009500492,
-0.0077110156,
0.013782221,
0.04190628,
-0.0070342687,
-0.007092833,
-0.043207716,
0.008439821,
-0.009363841,
-0.016333038,
-0.0080558965,
-0.022254577,
-0.005303357,
0.019118113,
-0.0018268926,
-0.025195826,
-0.0067869956,
-0.033785313,
-0.009578578,
-0.0014242604,
-0.012246525,
-0.0036277564,
-0.015864521,
-0.010027574,
-0.013534947,
-0.012884229,
-0.026653435,
-0.04068293,
-0.0065624975,
-0.0010419632,
0.010216283,
0.037325222,
0.024440993,
-0.026562335,
-0.013704134,
0.026510278,
0.00042500062,
-0.00013898943,
-0.026809609,
0.0120057585,
-0.022762138,
0.0429214,
0.0106913075,
0.0042101494,
0.02449305,
-0.01926127,
0.03321268,
0.021890175,
-0.026002716,
-0.030193346,
-0.012200975,
-0.00830317,
-0.042192597,
0.0035561773,
-0.008133983,
-0.015474089,
-0.021473715,
-0.015552175,
0.020068163,
-0.0013258392,
0.02315257,
-0.01991199,
0.013242125,
-0.013704134,
0.01750433,
-0.005397711,
-0.0004069025,
-0.0046689063,
-0.014719255,
-0.0020351226,
-0.013203081,
0.020081177,
-0.005277328,
-0.005352161,
0.022540893,
-0.030375546,
0.008094939,
-0.006477904,
-0.015708348,
0.008296663,
-0.014537054,
-0.018974956,
-0.0022108166,
0.007040776,
0.0023865106,
-0.019274287,
0.008947381,
0.013508919,
-0.01017724,
0.0124482475,
0.013138009,
-0.01156327,
0.033551052,
-0.026913723,
-0.0012770353,
-0.019846918,
0.02291831,
0.0058987644,
-0.008173026,
-0.020042134,
-0.0095981,
-0.023477929,
0.0056579984,
0.008153505,
0.039329436,
-0.00943542,
-0.015122701,
0.0053131175,
0.024662236,
-0.017881747,
-0.034097657,
0.023699174,
-0.017087871,
0.012018773,
-0.0025947406,
-0.019053042,
-0.003813211,
0.015044615,
-0.0099429805,
0.004415126,
-0.010235804,
-0.0030762723,
0.004031202,
0.02125247,
0.00035260816,
0.01568232,
-0.007027761,
0.0054107253,
0.00012241644,
0.0050495765,
0.014758299,
0.030011144,
-0.03670053,
0.01803792,
-0.011719443,
0.011322504,
0.014667198,
0.013534947,
0.019339358,
-0.0072359913,
-0.014914471,
0.033785313,
0.0063705356,
0.02139563,
0.019209214,
0.008530921,
-0.0039954125,
0.00092727406,
-0.015630262,
-0.00913609,
-0.03693479,
0.010216283,
0.021135341,
0.0021099553,
-0.020783953,
-0.011882123,
-0.015552175,
-0.006061444,
0.0013038774,
-0.009058003,
0.002150625,
-0.027876787,
-0.02696578,
-0.0019326344,
-0.00045957003,
0.017387202,
0.000871963,
0.009877909,
0.00047258442,
0.01022279,
-0.019417444,
0.021720989,
0.012057817,
0.011686907,
-0.029724827,
0.008595993,
-0.028189132,
-0.027095923,
-0.000843494,
0.00038595748,
-0.013007865,
-0.023048455,
-0.011407098,
0.0064746505,
0.030427603,
-0.02654932,
0.023516972,
0.009363841,
0.025911616,
0.004119049,
-0.019378401,
0.0028338796,
0.0052187634,
0.008609007,
0.016228924,
-0.025950659,
-0.00668288,
0.005212256,
-0.006077712,
-0.013027387,
-0.0012095233,
-0.019742804,
-0.021447686,
0.005557137,
0.012461262,
-0.017894762,
-0.0011778007,
-0.006412832,
-0.0129297795,
0.0055148406,
0.0045224945,
-0.006852067,
-0.005462783,
-0.004268714,
0.009168626,
0.0026695733,
-0.019508544,
-0.013847292,
-0.010834466,
-0.017608447,
-0.018961942,
-0.011127288,
-0.014771313,
0.033368852,
-0.012760593,
-0.018493423,
-0.011485184,
0.003526895,
-0.022983382,
0.0066893874,
0.0086025,
0.0030746455,
0.0040832595,
0.027408268,
0.009702215,
-0.008882309,
0.0098128375,
-0.0029705307,
-0.01639811,
-0.019053042,
0.012539349,
-0.012610927,
0.036778618,
0.0055896733,
-0.059762,
-0.008127476,
0.036622446,
-0.033290766,
-0.0027915828,
0.02842339,
0.009708722,
-0.018285194,
-0.0023084243,
-0.00029485687,
0.015174759,
0.012090352,
0.040292498,
-0.035555266,
-0.011127288,
0.013151024,
-0.010762886,
-0.0065234546,
0.0037969432,
0.0037676608,
-0.0106848,
0.008257619,
-0.018089978,
-0.012305089,
0.004437901,
0.0056189555,
-0.0021213428,
0.026145875,
0.017634476,
0.0071058474,
0.013164038,
-0.025794487,
0.000087236964,
0.0020302422,
-0.0046591456,
-0.0036277564,
0.009422406,
0.011368055,
0.008817238,
-0.018883854,
0.0048738825,
-0.019378401,
0.004951969,
0.017165957,
0.0015934473,
-0.010463555,
0.036596417,
0.00083536,
0.01568232,
-0.027668556,
-0.0026337837,
-0.009533028,
-0.012057817,
-0.022801181,
0.0038652688,
-0.015643276,
-0.018753711,
0.0056775203,
-0.01264997,
-0.0051146485,
0.006773981,
-0.020341465,
-0.017152943,
0.009786808,
0.18730286,
-0.015526147,
-0.000004070169,
0.017712561,
-0.014354853,
0.0044183796,
0.0013046908,
-0.0141596375,
0.008550443,
-0.0036245028,
0.041776136,
-0.011302982,
-0.00012363654,
-0.002959143,
0.017244045,
-0.011368055,
-0.013873321,
-0.013131502,
-0.0062761814,
0.0004093427,
-0.0150316,
0.0017943566,
0.013769207,
0.0064095785,
0.011791022,
0.0025459367,
0.00034345742,
0.0010492838,
0.014445954,
-0.00818604,
0.004135317,
-0.00876518,
-0.003183641,
0.0069691967,
0.0016267966,
0.006149291,
-0.010997145,
-0.030505689,
-0.01165437,
0.008081925,
-0.022801181,
0.019547587,
-0.03646627,
0.003183641,
0.002702109,
0.020146249,
0.0035008662,
-0.008244605,
-0.006858574,
0.026991809,
-0.03198933,
-0.0011257433,
0.029881,
-0.0024011517,
0.0000398311,
-0.0019261271,
0.03029746,
0.0054985727,
-0.010808436,
0.0032568467,
0.0018545481,
-0.011823557,
-0.0035073734,
0.013977436,
-0.006494172,
-0.013508919,
0.0022905297,
0.0065527367,
0.0340456,
0.012279061,
0.022996396,
0.008966903,
0.010788915,
0.0094614485,
0.011966716,
-0.014563083,
-0.004421633,
0.018324237,
0.0071774265,
0.0009134463,
0.0009606234,
0.018883854,
-0.007984318,
0.006660105,
-0.014302796,
-0.024922524,
0.007626422,
0.02273611,
-0.011368055,
0.018558495,
-0.00078004895,
-0.026276018,
-0.021044241,
0.011862601,
0.031442724,
-0.01732213,
-0.030818034,
0.023829317,
0.00985188,
-0.00084918784,
-0.019833904,
0.09234999,
0.0014218203,
-0.00088985777,
-0.012070831,
0.00321455,
-0.026913723,
0.01535696,
-0.00668288,
0.011133796,
0.003894551,
-0.02211142,
0.015695333,
-0.016359067,
-0.0149405,
0.011530735,
0.0255342,
-0.03279622,
0.034592204,
-0.021747017,
0.009051496,
-0.029724827,
-0.003575699,
0.0170228,
-0.0148624135,
0.014979543,
-0.01589055,
0.00938987,
0.0012876095,
-0.03277019,
-0.0072815414,
0.011530735,
-0.011843079,
-0.0056091947,
-0.03591967,
0.015864521,
-0.00596709,
0.028813822,
-0.011224897,
0.024766352,
0.00016715335,
0.00017162703,
0.02211142,
0.009207669,
-0.00073653215,
-0.02333477,
0.0085114,
-0.02021132,
-0.016632369,
-0.025065683,
-0.009266233,
-0.01628098,
-0.0007922499,
-0.005176467,
0.0075938865,
-0.012363655,
-0.014563083,
-0.03690876,
0.0023816302,
0.024831424,
-0.040006183,
0.0020123473,
0.032926362,
-0.043311834,
0.0051081413,
0.0074246996,
-0.1612741,
0.009565564,
0.029360425,
-0.016241938,
0.03217153,
-0.010801929,
0.016189879,
-0.020185292,
-0.016840598,
-0.00927274,
0.017270073,
0.004974744,
-0.0101186745,
-0.020224335,
0.010359441,
0.0022645008,
0.010320398,
0.015474089,
0.020198306,
0.0035073734,
0.0043175183,
-0.03279622,
0.030193346,
-0.02696578,
-0.006259913,
0.011784514,
0.013587005,
-0.00588575,
0.01940443,
0.004812064,
-0.010827959,
-0.020796968,
0.012513319,
-0.0014161264,
-0.0014933993,
0.0027362718,
0.021590844,
0.013743178,
-0.01473227,
0.0215518,
0.023855345,
0.025247883,
-0.01621591,
-0.013534947,
0.0070017325,
0.027486356,
0.005475797,
-0.013469876,
0.025260897,
0.004812064,
0.029620713,
-0.018519452,
-0.00034976128,
0.008569964,
0.012168438,
0.008068911,
0.0102097755,
0.016189879,
-0.013404804,
-0.034618232,
-0.0073596276,
-0.003917326,
0.009799822,
0.0153439455,
-0.003670053,
-0.032535933,
0.0007133503,
0.0036179957,
-0.022345679,
-0.00044411546,
-0.035763495,
0.022072377,
-0.009363841,
0.0073140776,
0.020796968,
0.015994664,
0.0059996257,
-0.003271488,
0.004132063,
0.028345304,
-0.0145110255,
-0.00014214135,
-0.012656477,
-0.02044558,
-0.0023930178,
0.032249615,
0.010235804,
0.0039140726,
0.0032682344,
-0.0016902416,
0.022970367,
-0.034982633,
0.008498386,
0.00007808624,
-0.00596709,
0.027304154,
0.0042426856,
-0.013352746,
-0.015851505,
-0.016775526,
0.024649221,
0.0005571778,
-0.016502224,
0.009916952,
0.036622446,
0.0098583875,
-0.0015649783,
0.014328824,
0.03448809,
-0.0038750295,
0.0009980397,
-0.0025312954,
0.008986425,
0.015422031,
-0.024193719,
0.04336389,
-0.00074344606,
0.008615515,
-0.008752165,
-0.034514118,
0.061271667,
0.017283088,
-0.0068976176,
0.022046348,
-0.014367867,
-0.03318665,
-0.13587005,
-0.004789289,
0.011673892,
0.008439821,
-0.011621835,
0.013216096,
0.0020855532,
0.004311011,
-0.009786808,
0.02654932,
-0.0075548436,
-0.021109313,
-0.02035448,
0.012968822,
0.023048455,
-0.0010175613,
0.00086626917,
-0.008843266,
-0.014823371,
0.03149478,
0.007815131,
-0.006871589,
-0.0077825948,
-0.000077527024,
-0.0067674736,
-0.011895137,
-0.00212785,
0.0007926566,
0.0016446913,
0.008823745,
0.015187773,
0.0004056824,
0.021304527,
0.00026476115,
-0.018623568,
-0.010073124,
0.009103553,
-0.010196761,
0.018116007,
-0.02678358,
0.0017797155,
0.025156783,
0.037403308,
0.0012933033,
0.019248256,
-0.030635834,
-0.033472966,
0.008530921,
-0.0013884709,
0.0007914365,
-0.008706615,
-0.0052090026,
-0.008400777,
-0.0057881423,
0.026028745,
-0.033629138,
0.008068911,
0.023529986,
-0.037325222,
0.001603208,
-0.02777267,
-0.007867188,
-0.0030063202,
0.0018968448,
-0.017725576,
0.0058239317,
-0.013886335,
-0.029542627,
-0.004262207,
-0.030505689,
-0.022332663,
0.008966903,
-0.016267966,
-0.011660878,
-0.028891908,
0.0069952253,
-0.0037871825,
0.000939475,
0.036153927,
-0.017465288,
-0.025755445,
-0.016333038,
0.021187399,
-0.016150836,
0.023673143,
0.0003326799,
0.02481841,
0.00521551,
0.011712936,
-0.03170301,
-0.016137822,
0.023894388,
-0.03469632,
-0.03628407,
-0.014042508,
0.0067154164,
-0.014693227,
-0.019690746,
0.0044509154,
0.02375123,
-0.01970376,
-0.0152138015,
-0.04791892,
0.015382988,
0.036232013,
-0.011172839,
-0.005814171,
-0.021499744,
0.042817287,
0.000033425586,
0.02437592,
-0.0011411979,
-0.029933058,
0.017270073,
-0.014550068,
-0.017595433,
-0.022345679,
-0.018024907,
0.0512506,
-0.0023962713,
0.018389309,
0.01750433,
0.004903165,
0.007984318,
0.017855719,
0.022983382,
-0.0030030664,
-0.00938987,
-0.010541642,
0.011420112,
-0.011244418,
-0.0046266094,
0.01010566,
-0.036023784,
-0.026367119,
-0.00943542,
-0.03670053,
-0.008810731,
-0.017374188,
0.014784328,
-0.0054953187,
0.03646627,
-0.0059703435,
-0.017126914,
0.031729043,
-0.01940443,
-0.00985188,
-0.0048023034,
-0.013001358,
0.013573991,
-0.017803662,
-0.018584525,
0.010404991,
0.0062501524,
0.004737232,
-0.045342073,
-0.023920417,
-0.0035366558,
0.016840598,
0.0155651895,
-0.02863162,
0.004558284,
0.005352161,
0.019013999,
-0.023543,
0.009162119,
0.0036798138,
-0.0030876598,
-0.016749498,
-0.013964422,
0.019053042,
-0.037038904,
-0.03342091,
-0.012454755,
0.0055701514,
-0.009357334,
-0.0058890036,
-0.0042036423,
-0.009617621,
0.011472169,
0.004232925,
0.00867408,
0.01803792,
-0.0035659382,
-0.010346427,
0.013294182,
0.008498386,
-0.0063933106,
-0.0061525446,
0.0031868946,
0.018311223,
0.0014193801,
-0.0120968595,
0.015018586,
-0.0006767474,
0.027902815,
-0.00048519208,
0.007899724,
-0.008003839,
-0.00048519208,
-0.019872947,
0.029360425,
-0.0030193345,
0.0031641193,
0.010671786,
-0.0069431677,
-0.027147982,
0.025768459,
-0.03862666,
-0.041593935,
-0.025794487,
0.016411124,
0.0127540855,
0.023529986,
0.033759285,
-0.007756566,
0.0039466084,
0.032666076,
0.0069431677,
-0.036882732,
0.0012819157,
0.027121954,
0.005605941,
0.01926127,
-0.019443473,
0.0045940736,
0.032379758,
-0.008329199,
0.015695333,
-0.009975517,
0.015864521,
-0.005989865,
0.020250363,
-0.02386836,
-0.03716905,
-0.0039954125,
0.00033695024,
-0.017634476,
0.004548523,
0.01616385,
-0.009734751,
0.07340106,
-0.0042101494,
-0.014615141,
0.023516972,
-0.02943851,
0.021616872,
-0.002022108,
0.039954126,
-0.011140303,
-0.03321268,
-0.0017667011,
-0.017764619,
0.015708348,
-0.014003465,
-0.019222228,
0.026614392,
0.0049877586,
-0.0060484298,
-0.0039368477,
-0.006484411,
-0.00031722535,
-0.007372642,
-0.00088416395,
0.024440993,
-0.0213696,
-0.009559057,
0.017191986,
0.0019017252,
0.0024288073,
-0.060490806,
0.0057133096,
-0.0034911055,
-0.029022051,
-0.006988718,
0.024506064,
-0.009448434,
-0.012155424,
-0.040604845,
-0.012845186,
0.013144516,
-0.0016259832,
0.011856094,
-0.0074962787,
-0.036778618,
0.002207563,
-0.010600206,
-0.007047283,
-0.026809609,
-0.0015145476
] |
Murine ES cells can be maintained as a pluripotent, self-renewing population by LIF/STAT3-dependent signaling. The downstream effectors of this pathway have not been previously defined. In this report, we identify a key target of the LIF self-renewal pathway by showing that STAT3 directly regulates the expression of the Myc transcription factor. Murine ES cells express elevated levels of Myc and following LIF withdrawal, Myc mRNA levels collapse and Myc protein becomes phosphorylated on threonine 58 (T58), triggering its GSK3beta dependent degradation. Maintained expression of stable Myc | [
-0.03466195,
-0.027971875,
-0.004385421,
-0.030763796,
-0.02718171,
0.0038586438,
-0.017067585,
0.018726934,
-0.01556627,
-0.0033878365,
0.025219465,
0.008909121,
0.009271281,
-0.0029976922,
-0.015539931,
0.0008617748,
0.020886721,
-0.020570654,
0.013985937,
0.024942907,
-0.025232634,
0.015724303,
-0.013353805,
-0.023520608,
0.008573301,
0.010772596,
-0.0070851548,
-0.030316034,
-0.0074868225,
0.0061073243,
0.015447745,
0.002758996,
-0.012682164,
-0.013241865,
-0.028393297,
-0.0028594132,
-0.0016321866,
-0.012372682,
0.027550453,
0.0022404497,
0.022862136,
0.021097431,
0.0016988568,
-0.0014000754,
0.007282696,
0.011707626,
0.007388052,
0.00060908624,
-0.023362573,
0.037269495,
0.01345916,
-0.0012157033,
-0.015961353,
-0.009442483,
-0.029315157,
-0.00020361178,
0.013748888,
0.010002185,
0.010252403,
-0.014143971,
0.008178218,
-0.00894863,
-0.03142227,
0.021202788,
0.01277435,
0.0095873475,
-0.0037006107,
0.0038290126,
0.027234387,
-0.000109162254,
0.037480205,
0.010943798,
-0.01031825,
0.010252403,
-0.000509904,
-0.018687425,
-0.014525885,
0.014196648,
0.01787092,
-0.0025137155,
0.017067585,
-0.021887597,
-0.015711134,
0.036742717,
0.011569347,
-0.0063740057,
0.0055904244,
0.026391543,
0.0030388467,
0.0051854644,
0.011885413,
0.03671638,
0.012616317,
0.029920952,
-0.0110228155,
0.0024314066,
-0.007756796,
0.030105324,
0.012458283,
-0.011305958,
-0.024877058,
0.00591966,
-0.0015408236,
-0.019596117,
-0.026259849,
0.0035228233,
0.0016832182,
-0.014354682,
0.026233511,
-0.010759426,
-0.028946413,
0.023968369,
0.004935245,
-0.035847194,
0.029183464,
-0.006821766,
-0.00029446027,
0.010127294,
-0.020517977,
0.011674702,
0.013577686,
0.017963106,
0.012938968,
-0.015118509,
0.0016140786,
0.03526774,
-0.010186557,
-0.0015523469,
-0.04203683,
0.017159771,
0.021018416,
-0.013340635,
-0.0005724588,
0.022150986,
-0.016777858,
-0.015697964,
-0.01696223,
0.011365221,
0.0034273448,
-0.032818228,
-0.002067601,
0.025390666,
0.006008554,
-0.013748888,
0.0012107647,
-0.0050899857,
0.011411314,
-0.027497776,
0.0007025069,
0.0035524545,
-0.0005790435,
-0.030158002,
0.03487266,
-0.0018535977,
-0.00086259784,
0.019872675,
-0.0011868952,
0.020847213,
-0.0059525836,
-0.0043327436,
0.015737472,
0.0006222557,
0.009936337,
0.010871367,
0.018529393,
0.033766426,
0.0067131184,
0.006690072,
0.0056003015,
0.0049549993,
0.013498669,
0.033186972,
-0.026128154,
0.027260726,
-0.019438082,
0.025943782,
-0.01717294,
0.0072629424,
-0.022388035,
-0.0073222048,
0.00015659278,
0.029657563,
0.017752396,
0.02369181,
-0.020952567,
-0.001544116,
0.015921844,
-0.016290588,
-0.011529839,
-0.0021811873,
-0.003180418,
-0.0027919197,
0.029578546,
-0.014789273,
-0.6325542,
-0.01880595,
0.022045631,
0.0078094737,
-0.0014692149,
0.035425775,
-0.013195772,
-0.000716911,
-0.016764687,
0.018292341,
-0.018410867,
0.012543885,
0.0056003015,
-0.017357312,
-0.009765134,
-0.032370467,
-0.008981553,
-0.015961353,
0.02997363,
0.007381467,
-0.037243158,
0.0023458053,
0.00411874,
0.03671638,
-0.0019276758,
0.037532885,
0.03758556,
-0.02394203,
-0.0013424591,
0.028314281,
-0.012780935,
0.027813843,
-0.012807273,
-0.005205218,
0.046014,
-0.0045237,
-0.011957845,
0.017278295,
-0.0027227802,
0.036321297,
-0.021874428,
-0.0021795412,
0.025206294,
0.019635625,
-0.017818242,
0.009890244,
-0.009027646,
0.012102709,
-0.0058241817,
-0.0064892382,
0.015118509,
-0.0018223203,
-0.033081617,
-0.013445991,
0.0067493343,
0.016066708,
0.022862136,
-0.001718611,
0.014986815,
-0.003483315,
-0.0072102644,
0.013735718,
-0.019161524,
0.016751518,
-0.0068876133,
0.017120263,
-0.00028643516,
0.002270081,
0.01764704,
0.0034141755,
0.021650547,
0.020030707,
0.001599263,
0.022638256,
0.006508992,
0.03345036,
-0.01276118,
0.004658687,
-0.0031491406,
-0.007414391,
0.0008650671,
-0.010160217,
-0.017515346,
0.01066724,
0.00987049,
0.007249773,
-0.018740103,
0.012109294,
-0.016632995,
0.024679517,
-0.00019404336,
-0.007684364,
0.011444237,
-0.018028954,
-0.0017153186,
0.0022634962,
-0.0067954273,
0.0079214135,
0.016448623,
-0.037348513,
-0.011641779,
-0.012484622,
0.012227818,
0.0029697071,
0.01950393,
0.0078292275,
-0.031185217,
0.0141703095,
0.034424897,
-0.03321331,
0.012366097,
0.0072168494,
0.0023046508,
-0.029157124,
0.0039146137,
-0.022875305,
0.013841074,
0.01195126,
-0.012418775,
-0.023494268,
0.013656702,
-0.015065831,
0.02067601,
-0.0009136294,
-0.0061830487,
0.032186095,
0.005066939,
0.008467945,
0.00088811363,
0.0042965277,
0.009376636,
0.002242096,
0.035504792,
-0.032633856,
0.02647056,
-0.00051895797,
0.01312334,
0.019385405,
0.031448606,
0.0022206956,
-0.04714657,
-0.0010996476,
-0.0025417006,
-0.014249327,
-0.019622454,
-0.015210695,
0.008118955,
-0.0008831751,
0.019833166,
-0.008606224,
-0.0039376603,
-0.002344159,
-0.0033318666,
0.018608408,
0.009705872,
-0.0125373,
-0.007289281,
-0.009146171,
-0.0033845443,
-0.010496038,
-0.01719928,
0.025930613,
-0.023270387,
0.0011498561,
-0.00906057,
0.013426237,
-0.0027277188,
0.009304204,
-0.006011846,
-0.026049139,
-0.0037236572,
0.009100078,
-0.01950393,
-0.0052974042,
0.0043524974,
-0.000044061013,
-0.009139586,
-0.01112817,
-0.007822643,
-0.010891121,
-0.0013284666,
-0.0149341365,
0.009903413,
-0.0058241817,
0.027260726,
0.028314281,
0.018015783,
-0.0022848966,
0.004839767,
0.023599625,
-0.020596992,
0.0029976922,
-0.01115451,
0.017726056,
0.020913059,
-0.015460914,
0.013077247,
0.0066341017,
0.01671201,
0.023402082,
0.008053108,
0.004540162,
0.020649672,
-0.029499529,
-0.004945122,
-0.032660194,
-0.00858647,
-0.030816473,
0.0132682035,
0.007289281,
0.008678656,
0.011253281,
-0.02138716,
-0.024916567,
0.015184356,
0.0095873475,
-0.0033236356,
-0.022190494,
-0.015961353,
0.003888275,
0.008843274,
0.00325285,
0.0038388898,
-0.007144417,
0.019345896,
0.010212895,
0.002574624,
0.008020185,
-0.014486376,
-0.0026980876,
-0.0068876133,
0.006469484,
0.016672501,
-0.0054488527,
0.019806826,
-0.005613471,
0.007848982,
-0.020610163,
0.04153639,
-0.010403852,
0.00043335665,
0.010278743,
-0.0040660626,
-0.0077238725,
-0.009106663,
-0.030500406,
0.019819997,
0.011714211,
-0.03142227,
0.015026323,
-0.019411745,
0.02786652,
-0.0050965706,
0.0034306373,
-0.0038586438,
-0.011556177,
-0.009244942,
0.007506577,
0.030158002,
0.018963983,
-0.0066801948,
-0.011213772,
0.03184369,
-0.009699287,
-0.00719051,
0.015171187,
-0.008652317,
-0.0019177987,
-0.014012276,
-0.019108847,
-0.03326599,
0.015079001,
0.010476284,
-0.0070258924,
0.0025795626,
-0.00244293,
0.026760288,
0.013255035,
-0.008421852,
0.0023869597,
-0.026180832,
-0.03529408,
0.026352035,
0.028920075,
0.0015548161,
0.015737472,
-0.021729564,
-0.02041262,
-0.0008922291,
0.009258111,
0.0019589532,
-0.002197649,
0.012636071,
-0.013985937,
-0.009271281,
-0.0007300804,
0.018542562,
-0.023309896,
0.019819997,
-0.004385421,
0.017568024,
-0.0064563146,
-0.008731334,
-0.0019885844,
0.031079862,
-0.0015753934,
-0.002121925,
-0.018937644,
-0.0036545177,
-0.019754149,
-0.026523238,
-0.010344589,
0.0000139410795,
-0.015131678,
0.0074407295,
-0.0035392852,
0.0014346451,
-0.0031507867,
0.023612794,
0.013775227,
0.00085519004,
-0.028999092,
-0.0060809855,
-0.0032413267,
0.01997803,
0.02254607,
0.0033351588,
0.0077897194,
-0.005613471,
-0.0037532884,
-0.0039376603,
-0.015013154,
0.023336235,
-0.0069007827,
-0.010245819,
0.015487253,
-0.0020346774,
-0.021215957,
0.01902983,
0.022216834,
-0.015144848,
-0.03437222,
-0.009363467,
-0.021479346,
0.004263604,
-0.0017465961,
0.026562747,
0.04783138,
0.016422283,
0.013617193,
0.013985937,
0.017936768,
-0.007980676,
-0.005567378,
0.0050043846,
0.014683918,
0.000891406,
0.02462684,
0.00882352,
-0.030605761,
0.01835819,
0.026062308,
-0.011411314,
0.018516222,
0.029762918,
0.009310789,
0.005192049,
-0.0023918983,
-0.0041747103,
-0.014591732,
-0.011582516,
0.023138694,
-0.013057493,
-0.0048134276,
0.035636485,
-0.026852474,
-0.03113254,
-0.017502176,
0.01835819,
0.008026769,
0.011556177,
-0.015368728,
-0.004935245,
-0.020610163,
-0.006821766,
-0.0153160505,
0.009969261,
0.0049418295,
0.008296743,
-0.012603147,
0.006304866,
-0.010700164,
-0.026812965,
-0.012431945,
0.025166785,
-0.0052315574,
-0.03366107,
0.0138805825,
-0.0055278693,
0.028893735,
0.010384098,
0.0010181618,
-0.011253281,
0.040245786,
-0.015684795,
-0.018371359,
-0.006054647,
-0.025166785,
0.00950833,
0.001424768,
0.01604037,
-0.016053539,
-0.023533776,
-0.006867859,
0.02000437,
-0.0040594777,
0.013064077,
-0.015632117,
-0.019214202,
-0.0072629424,
0.010226064,
0.00586369,
-0.0039376603,
-0.0035359927,
0.0007267881,
-0.03547845,
-0.038876165,
-0.01719928,
-0.019754149,
-0.0097848885,
0.015434575,
0.017989445,
-0.02855133,
0.010891121,
0.012056616,
0.005550916,
0.006192926,
0.008915706,
0.01625108,
0.018503053,
-0.0004893267,
0.01183932,
0.0020758319,
-0.0037203648,
-0.000017529235,
-0.033819105,
0.029367836,
0.0019918766,
-0.024640009,
-0.0037335341,
0.013248449,
-0.003280835,
-0.031474944,
0.001681572,
-0.00534679,
0.040904257,
0.0050471853,
-0.011707626,
-0.016172064,
-0.01266241,
-0.0033368052,
0.005929537,
-0.010100955,
-0.030711118,
-0.0146444095,
0.010588224,
-0.00022799581,
-0.023718148,
0.009455653,
-0.02810357,
-0.015381898,
0.037085123,
0.017726056,
-0.002105463,
-0.016804196,
0.0024791458,
-0.013340635,
-0.013735718,
-0.020030707,
-0.052783087,
0.03223877,
-0.015526761,
0.046356402,
0.026773456,
0.03208074,
0.008672072,
0.017107094,
0.0023770826,
0.012622901,
-0.0041582487,
-0.0061698793,
0.03455659,
-0.003749996,
0.0246005,
-0.00042882966,
0.0014379375,
0.027524116,
-0.013143094,
0.0030026308,
0.047910396,
-0.011108417,
0.004273481,
0.00998243,
-0.028683025,
-0.025219465,
0.03500435,
-0.02162421,
0.013261619,
-0.01218831,
-0.017936768,
0.0077699656,
-0.013867413,
-0.011279619,
0.012181725,
0.011628609,
-0.039139554,
0.028366959,
-0.013999107,
-0.008191387,
-0.01440736,
0.012096124,
0.0079214135,
-0.0033368052,
-0.0016107863,
0.0002518654,
0.0014132448,
0.001232165,
-0.010812105,
0.023507439,
0.023481099,
-0.026891982,
-0.011780058,
-0.00586369,
-0.015065831,
0.0000037971436,
-0.03321331,
-0.028577669,
-0.031395927,
-0.012754596,
0.00928445,
-0.013281373,
0.008290158,
-0.018239664,
-0.0052216803,
0.039850704,
-0.004744288,
0.019345896,
-0.0021992952,
0.01394643,
0.021703225,
0.0025235927,
-0.035952553,
-0.02876204,
-0.008132125,
-0.0022108185,
0.019530268,
0.022216834,
-0.011575932,
-0.010476284,
0.008942045,
0.02506143,
-0.013893751,
-0.03342402,
0.012510961,
-0.010436775,
0.0018157356,
-0.02320454,
0.0043689595,
-0.013340635,
0.010226064,
-0.0091593405,
0.022690933,
-0.0018272588,
0.009317374,
-0.017212449,
0.030368712,
0.0121685555,
0.00569578,
-0.004513823,
-0.011180849,
-0.013972769,
-0.028524991,
-0.00869841,
0.0035228233,
-0.016435452,
0.03294992,
0.0007535385,
0.006881029,
0.007980676,
-0.0056727333,
-0.020478468,
-0.009725627,
0.004474315,
0.036268618,
-0.0077172876,
-0.005945999,
-0.0032413267,
-0.009850736,
0.006604471,
-0.010634317,
-0.019174695,
0.00036113054,
-0.04622471,
-0.0038026737,
0.03526774,
0.0095215,
-0.007131248,
0.001488969,
-0.024179079,
-0.024705855,
-0.023402082,
-0.010864782,
0.0015087231,
-0.034003478,
0.0035722086,
-0.0053105736,
0.027813843,
0.018884966,
-0.008849859,
-0.0021005245,
-0.008263819,
0.043485466,
-0.00011039689,
0.007499992,
0.0130245695,
-0.0053731287,
-0.013478914,
0.004612594,
-0.0021301557,
-0.032844566,
-0.005603594,
-0.008645733,
-0.027682148,
-0.004606009,
-0.003868521,
0.01787092,
0.018476713,
-0.030105324,
0.021294974,
0.008895952,
0.020583823,
-0.008955214,
-0.00086342095,
0.014222988,
-0.03458293,
-0.009626855,
0.0037631656,
0.018832289,
-0.006011846,
0.009106663,
-0.013643532,
0.0058669825,
-0.025140448,
-0.010377513,
-0.017739225,
-0.013169433,
-0.015144848,
-0.0046850257,
-0.012240988,
-0.0077633807,
-0.024587331,
0.0058603976,
0.013149679,
-0.006232434,
-0.03692709,
-0.0021482639,
0.022414375,
0.011016231,
-0.024745364,
-0.0009202141,
-0.015671626,
-0.024126401,
-0.020083385,
0.023257218,
-0.020043876,
0.036795396,
0.003595255,
0.010627733,
-0.01693589,
0.0067493343,
-0.068428375,
-0.013551346,
-0.0006313097,
0.005708949,
0.009653194,
-0.005287527,
-0.03134325,
-0.012767765,
-0.010706749,
0.00906057,
-0.0017597654,
-0.03803332,
-0.0000518032,
-0.0011654948,
0.009778304,
0.0037071954,
-0.0056398096,
-0.009817813,
0.020228248,
-0.006104032,
-0.004918783,
0.021005245,
-0.037875287,
0.017739225,
-0.002085709,
0.019372236,
-0.0040100925,
0.027787503,
0.02553553,
-0.021769073,
-0.0013375205,
0.03131691,
0.0010955322,
-0.00069797994,
0.0047179493,
-0.00080950855,
0.0011910106,
-0.0097848885,
-0.0005811012,
-0.00894863,
-0.0047311187,
-0.002436345,
0.038797148,
0.01881912,
0.024890227,
0.016198402,
0.0027310112,
-0.01195126,
-0.021940276,
0.021729564,
-0.008283573,
-0.0041977568,
-0.0026849182,
0.0010066385,
0.0058933212,
0.0032462652,
-0.0255487,
-0.0110294,
-0.01183932,
0.011226942,
0.009554423,
-0.02902543,
0.00371378,
-0.019003492,
-0.031791013,
-0.020939399,
0.003868521,
-0.023612794,
-0.029552208,
0.0006358367,
-0.0152238645,
-0.022401206,
-0.023546945,
0.0018025661,
-0.0037565806,
0.008606224,
-0.0020379697,
0.0017136724,
-0.009462237,
0.033529375,
0.20976272,
-0.021268634,
0.0055278693,
0.0064760684,
0.0130114,
0.0066604405,
0.013307712,
-0.0007271996,
-0.00010005682,
0.005057062,
-0.0010214541,
0.015724303,
-0.0020725394,
-0.0030437852,
0.01764704,
-0.016211571,
-0.014618071,
0.014894629,
-0.037295833,
-0.0021828334,
0.004652102,
-0.014038616,
0.007842397,
-0.004879275,
0.026536407,
0.003687441,
-0.03234413,
0.01230025,
0.025377497,
0.010074616,
-0.040798903,
0.011411314,
-0.0016642871,
0.012570224,
0.0054060523,
-0.0018091508,
-0.0024939612,
-0.023165032,
0.018726934,
-0.015210695,
-0.017989445,
-0.0012552115,
-0.012576808,
-0.016909553,
0.021913936,
0.0057682116,
-0.028340619,
-0.010403852,
-0.008830105,
-0.0022322189,
-0.049201,
0.0111150015,
0.0030536621,
0.012273911,
0.012748011,
-0.0070390617,
0.0063377894,
0.016619824,
-0.007243188,
0.0071180784,
-0.010449945,
-0.005929537,
-0.035952553,
0.007131248,
-0.02575941,
0.016409114,
-0.0045335772,
0.022677764,
0.0039639995,
-0.013643532,
-0.023033338,
0.01394643,
-0.011101832,
0.0010453238,
-0.004714657,
-0.017146602,
0.02390252,
0.015474084,
0.031290572,
0.016514469,
0.0021943566,
-0.004991215,
-0.029815596,
0.0071839257,
0.0020725394,
-0.0046751485,
0.023863012,
0.00063213275,
-0.024350282,
-0.0025219463,
0.013748888,
-0.0033878365,
0.0041944645,
-0.008283573,
0.01438102,
0.0019984616,
-0.0015984399,
-0.0071180784,
-0.007177341,
-0.0146444095,
-0.013669872,
0.06242311,
0.02997363,
0.018647917,
-0.0010321543,
0.0149341365,
-0.009455653,
0.011016231,
-0.018226495,
-0.022348527,
0.008566716,
-0.023388913,
0.0010897706,
-0.012616317,
-0.011240111,
-0.0006378944,
0.00580772,
-0.0053105736,
0.041299343,
-0.0021021708,
-0.0050406004,
-0.020794535,
0.0012288727,
0.03086915,
-0.0014815612,
0.0008152702,
-0.01266241,
-0.010877952,
-0.024745364,
-0.028999092,
-0.010166802,
0.0034273448,
0.0053533744,
0.0111150015,
0.02438979,
-0.014815612,
-0.007012723,
-0.018529393,
-0.026839305,
0.010489454,
-0.0010017,
-0.008560131,
-0.0016025554,
-0.005383006,
0.0064365603,
-0.0028199048,
0.027734825,
0.038744472,
-0.019793658,
-0.021110602,
-0.013814735,
-0.011720795,
-0.0049846303,
-0.010212895,
0.040245786,
-0.011911752,
-0.014104462,
-0.024284434,
-0.008751088,
0.034978013,
-0.021769073,
0.014657578,
0.00023746134,
-0.0018256126,
-0.004796966,
-0.007598763,
-0.16530272,
0.0056463946,
0.008072862,
-0.01577698,
0.035346758,
0.025719902,
-0.011984184,
-0.008309912,
-0.009989015,
0.016224742,
0.03276555,
0.01718611,
-0.06084278,
-0.038428403,
0.008145294,
0.018055292,
0.006285112,
0.05810354,
-0.005017554,
0.015935013,
0.036294956,
-0.0072300187,
0.004089109,
-0.0013383436,
0.0009539608,
0.0013992522,
-0.0056365174,
-0.017712887,
0.0012938968,
-0.027945537,
-0.01997803,
0.0038092586,
0.019819997,
-0.0056760255,
0.019385405,
0.005669441,
-0.0059328293,
0.0011679641,
-0.001232165,
0.035136048,
0.031448606,
0.009824397,
-0.01485512,
0.03042139,
-0.013162849,
0.02416591,
-0.00026873875,
0.024086893,
0.022809457,
-0.0070851548,
0.015579439,
-0.024574162,
-0.01928005,
0.019912183,
0.01509217,
0.010377513,
0.011411314,
0.0059953844,
-0.0030223848,
-0.00033005892,
-0.002941722,
-0.0047014877,
0.040087752,
-0.019174695,
-0.0057649193,
-0.037453867,
-0.019885844,
0.014947306,
-0.025693564,
-0.003463561,
-0.0075329156,
-0.0049418295,
0.021729564,
-0.010627733,
0.03576818,
0.0025417006,
0.000074849704,
0.009554423,
0.0028923368,
-0.003796089,
-0.027919197,
0.0260228,
-0.03500435,
-0.028604008,
-0.011681287,
0.008869613,
0.024784872,
0.019398574,
-0.0064003444,
-0.004668564,
0.00696663,
-0.026523238,
-0.017054416,
-0.011681287,
0.013189187,
0.00823748,
-0.015895506,
-0.008520623,
-0.009251527,
0.017528515,
0.03202806,
-0.018766442,
-0.018318681,
-0.006021723,
0.041378357,
-0.00813871,
-0.025746241,
0.002141679,
0.061211523,
-0.029420514,
0.0072168494,
0.0032248648,
-0.0009794766,
0.012906044,
-0.005909783,
0.03460927,
-0.003776335,
0.0005597009,
-0.004925368,
-0.022374867,
0.058577638,
-0.00091198325,
-0.0038619363,
0.024284434,
-0.0031787718,
-0.024929736,
-0.13548712,
-0.037717257,
0.0077238725,
0.015711134,
-0.018489884,
0.0141703095,
-0.004698195,
0.020399451,
0.007572424,
0.006525454,
-0.009435899,
-0.013215526,
0.0097848885,
-0.010193141,
0.022032462,
-0.0131167555,
0.022572407,
-0.0034306373,
-0.024113232,
0.039192233,
0.009205434,
0.0060875705,
-0.007868736,
-0.01950393,
0.014828782,
0.028024552,
-0.033028938,
0.023072846,
-0.0020231542,
0.036532007,
0.018055292,
-0.004303112,
0.019793658,
0.0014527531,
-0.024811212,
-0.009607101,
0.0063740057,
-0.025469683,
0.06310792,
-0.022045631,
0.0010691934,
0.01485512,
0.01763387,
-0.0051229093,
0.0011021169,
-0.010989891,
-0.013762058,
0.008171633,
0.022598747,
-0.024073724,
-0.04577695,
-0.030026307,
-0.0134855,
0.0014897921,
0.021215957,
-0.005392883,
0.010555301,
0.0056924876,
-0.006782258,
0.0036446406,
0.019819997,
-0.016817367,
-0.0063213278,
0.0027672271,
0.031185217,
0.007098324,
-0.020228248,
-0.039666332,
0.035952553,
-0.0038816903,
-0.012102709,
-0.003262727,
-0.011589101,
0.011082077,
-0.024771703,
-0.0022651425,
-0.004889152,
-0.024060555,
-0.0125504695,
-0.015026323,
-0.00017789024,
-0.015750641,
0.01277435,
-0.02881472,
0.027050015,
-0.010133878,
0.014236157,
-0.00045023,
-0.0062653576,
0.0014634533,
-0.009323958,
0.045144815,
0.009501746,
-0.011365221,
-0.003555747,
0.005643102,
0.0029450145,
-0.007644856,
0.018397698,
0.024060555,
-0.0020741858,
-0.02000437,
-0.06321328,
0.015289712,
-0.015434575,
-0.0070324773,
0.008086032,
-0.035504792,
-0.0011901875,
-0.028287942,
0.014565392,
0.0070851548,
0.0024939612,
0.004935245,
-0.009053985,
-0.0027771043,
-0.015737472,
-0.007816059,
0.023033338,
-0.021479346,
0.027550453,
0.030263357,
-0.0015737473,
-0.008988138,
0.0029071523,
-0.0077699656,
-0.006140248,
0.0114508215,
-0.007526331,
0.03719048,
-0.014420529,
-0.008020185,
-0.011108417,
-0.047462635,
-0.010515792,
0.014762934,
-0.034003478,
-0.03829671,
0.007282696,
0.04016677,
0.027734825,
0.007684364,
-0.017739225,
-0.029078107,
0.013307712,
-0.0023013584,
0.0040068,
0.0004778035,
-0.022388035,
0.00040063885,
0.003180418,
0.007592178,
0.026352035,
0.0019293219,
0.005392883,
-0.010673826,
0.00068151817,
-0.015013154,
0.0065320386,
-0.010417022,
-0.012925798,
-0.0052282647,
-0.0012362805,
0.015697964,
0.012366097,
0.001029685,
-0.007783135,
-0.014591732,
-0.04224754,
0.0071378327,
-0.0049418295,
-0.020755026,
-0.02599646,
0.0030223848,
0.019648794,
0.010956968,
0.022098308,
0.009034231,
-0.00037018454,
0.008625979,
-0.033792764,
0.02391569,
0.005992092,
-0.018424036,
-0.012458283,
-0.00040063885,
0.023625962,
0.013775227,
-0.010021938,
0.017607532,
-0.005834059,
-0.015052662,
-0.011543008,
0.012517546,
0.012985061,
0.001405837,
0.01693589,
0.037032444,
-0.009271281,
0.0032660193,
-0.021110602,
0.015355559,
-0.01322211,
-0.004945122,
0.018424036,
-0.04251093,
-0.012175141,
0.039113216,
-0.02905177,
-0.045855965,
-0.019266881,
0.0014321759,
0.008593055,
-0.0019145063,
-0.02553553,
0.0039047368,
-0.0064760684,
0.0070390617,
0.0042767734,
-0.017541684,
-0.0060414774,
0.029315157,
0.007289281,
0.009778304,
0.0028742286,
-0.008731334,
0.0069863843,
0.016330097,
0.027234387,
-0.019227372,
0.031448606,
-0.025838427,
0.029236142,
0.0129784765,
-0.019648794,
-0.016843705,
-0.015908675,
-0.018239664,
-0.0068151816,
0.018371359,
-0.02208514,
0.09081641,
0.011793227,
-0.022111477,
-0.011957845,
-0.0056365174,
0.024047384,
0.015763812,
0.02228268,
-0.029367836,
-0.033371344,
0.017791905,
-0.03234413,
-0.0005197811,
-0.045408204,
-0.016698841,
0.016909553,
-0.0051788795,
0.012589978,
-0.024021046,
-0.010542131,
0.0035458698,
0.00626865,
-0.0038751056,
0.0024346989,
-0.02926248,
-0.0014873229,
0.04369618,
-0.012010523,
-0.0050340155,
-0.022322189,
-0.002307943,
0.005020846,
-0.032212432,
-0.0010066385,
0.0059394143,
0.008968384,
-0.00046216478,
-0.04114131,
0.023823503,
0.026088646,
-0.013287958,
-0.0154082365,
0.008546962,
-0.022704102,
0.0013152971,
-0.011075493,
-0.011273035,
0.011483746,
-0.012464868
] |
Cardiovascular mortality is 10 to 20 times increased in patients with chronic renal failure (CRF). Risk factors for atherosclerosis are abundant in patients with CRF. However, the pathogenesis of cardiovascular disease in CRF remains to be elucidated. The effect of CRF on the development of atherosclerosis in apolipoprotein E-deficient male mice was examined. Seven-week-old mice underwent 5/6 nephrectomy (CRF, n = 28), unilateral nephrectomy (UNX, n = 24), or no surgery (n = 23). Twenty-two weeks later, CRF | [
-0.0022512032,
-0.02187632,
0.020893263,
-0.037329994,
-0.008500176,
0.017747477,
-0.02726348,
0.018180022,
-0.040030126,
0.021483097,
-0.0065406132,
0.0072156466,
0.0023101866,
-0.006203097,
-0.008657465,
0.011973648,
0.03017333,
0.0052954066,
0.019805344,
-0.024877924,
-0.04217975,
0.0470295,
-0.004364778,
-0.022557907,
-0.001150178,
-0.00036721316,
0.01088573,
-0.038247515,
0.002277418,
-0.048235387,
0.022348188,
0.0032096847,
-0.017013459,
-0.02388176,
-0.018284881,
0.029439313,
-0.011023358,
0.0022643106,
0.00084870687,
-0.019556303,
0.026201775,
0.00082904566,
-0.008054523,
0.02340989,
-0.009378375,
-0.006638919,
0.009044135,
-0.024222553,
-0.005888518,
0.029701462,
0.025690585,
0.006294849,
-0.00063366286,
-0.012373425,
-0.0055313404,
0.008690233,
-0.0077596055,
0.022348188,
-0.0020349303,
-0.0055477247,
0.010538383,
0.010669458,
-0.008585374,
-0.0024478147,
-0.035023086,
0.005213485,
-0.00039875295,
0.019176187,
0.0028590607,
0.014011855,
0.02525804,
0.024943462,
-0.016095938,
0.0026984946,
0.0072156466,
0.016213905,
-0.015702715,
0.009535664,
-0.010892284,
0.004273026,
0.016580913,
-0.025782337,
-0.020355856,
0.029072305,
0.028469363,
-0.020329641,
0.000043623204,
0.007294291,
0.009273515,
0.015388137,
0.0051184557,
0.013231962,
0.012071954,
0.006730671,
-0.004859584,
-0.00349641,
0.015335707,
0.010459739,
0.006452138,
-0.022990452,
-0.03421042,
0.012917384,
-0.013120549,
-0.01280597,
-0.037697002,
0.021850105,
-0.032034587,
0.0024838601,
0.023907974,
-0.027394554,
-0.012543822,
0.057358164,
0.022125361,
-0.009607755,
0.016725095,
-0.036753267,
0.02048693,
0.0023364015,
0.0046400344,
0.00047391595,
0.020001955,
-0.0014721295,
0.03431528,
-0.004436869,
-0.0056263693,
0.0009756852,
-0.0067568864,
0.0065143984,
0.0080610765,
-0.004603989,
0.0021954966,
-0.0027820545,
0.00817249,
-0.0017269055,
-0.024550239,
0.019307261,
-0.022780733,
0.013553095,
-0.012589698,
-0.04944127,
-0.001092833,
0.026765395,
-0.019123757,
-0.0046203732,
-0.019648055,
0.03038305,
0.016279442,
-0.0047547244,
0.0071763243,
-0.026568783,
-0.012183367,
-0.0030491187,
0.016987244,
-0.02351475,
0.0042074886,
-0.0024134077,
-0.013435127,
0.015991079,
-0.022453047,
-0.017249392,
-0.013880781,
0.0018956638,
0.010820193,
0.0024052155,
0.008913061,
-0.0032735835,
0.0054363115,
-0.00021442956,
0.006196543,
0.011652515,
-0.006268634,
0.0020267381,
0.005403543,
0.034551214,
0.032821033,
0.0064160926,
-0.01065635,
0.008723002,
-0.036150325,
-0.031693794,
-0.020460716,
0.011691838,
0.023422997,
0.0028738065,
-0.016515376,
0.0088933995,
0.032244306,
-0.025651263,
-0.0043451167,
0.0017269055,
-0.0019644778,
0.016790632,
-0.00073606474,
-0.025402222,
-0.64635414,
-0.004082968,
0.0046662493,
0.0025887198,
0.006248973,
0.027289694,
0.00896549,
0.009221085,
-0.024261875,
0.00806763,
-0.007923448,
0.012504499,
0.0112068625,
-0.008506729,
-0.0000044192816,
-0.020618005,
-0.0003145786,
0.0013533434,
0.013284392,
0.010485954,
-0.0041616126,
0.0061637745,
-0.025992056,
0.009509449,
-0.0007630989,
0.012760094,
0.00015882532,
-0.024681313,
-0.01736736,
0.022243328,
0.010446631,
0.016869277,
-0.017498435,
0.0019431782,
0.046243053,
-0.012183367,
-0.0059278402,
0.029229594,
0.0035750547,
0.04107872,
-0.01951698,
0.019582517,
0.016515376,
-0.0038863565,
-0.0054166503,
0.023921082,
0.01506045,
-0.0035390093,
0.0012968176,
0.011265846,
0.0047776625,
-0.00014940435,
-0.027945066,
0.0063243406,
-0.010302449,
-0.016017294,
0.022662766,
-0.014876946,
-0.01296326,
0.01178359,
-0.0013050097,
0.010643243,
-0.021968072,
-0.010610474,
0.00513484,
0.022243328,
-0.02684404,
0.005197101,
0.011469011,
-0.0025657816,
0.019281046,
0.020919478,
0.004695741,
-0.020172352,
0.029622817,
0.007936556,
0.0071697705,
0.012124384,
-0.03649112,
-0.0017154365,
0.0043844394,
0.02510075,
-0.0006127729,
0.02038207,
0.0051446706,
0.011246185,
-0.019634947,
0.0115083335,
-0.0030065195,
-0.011757375,
0.0033948275,
-0.0008413339,
-0.01639741,
-0.036858127,
-0.013402359,
0.028757727,
0.0018219344,
0.015558533,
0.014719657,
-0.023029774,
-0.017485328,
0.003191662,
-0.0014582028,
-0.0007737487,
0.012314442,
-0.00012605672,
-0.020683544,
-0.018271774,
0.03790672,
-0.032768603,
-0.01762951,
-0.0116000855,
-0.0035750547,
-0.028652867,
-0.00806763,
-0.01762951,
0.002596912,
0.0015065366,
0.01608283,
-0.034944437,
0.028521793,
0.001459022,
0.032506455,
-0.01875675,
0.011344491,
-0.0025084366,
-0.01116754,
-0.0031130174,
-0.0024822217,
-0.030514125,
0.017655725,
-0.0039551705,
0.033974487,
-0.0016384302,
0.02305599,
-0.024327412,
0.0006901887,
0.01116754,
-0.0028885524,
-0.029937396,
-0.0064849067,
-0.003384997,
0.010603921,
-0.006907622,
0.008572266,
0.0124324085,
0.032847248,
-0.00021361034,
-0.005193824,
-0.006527506,
-0.0044761915,
-0.03156272,
-0.0012992752,
0.02561194,
-0.002392108,
-0.007182878,
0.017446004,
-0.0051839934,
-0.017760584,
-0.01021725,
0.032401595,
0.003873249,
-0.018835394,
0.01956941,
0.0040010465,
-0.016030401,
-0.0049611665,
0.0033260132,
-0.016043508,
-0.017341144,
-0.012655235,
-0.014837624,
-0.007412258,
-0.0016351533,
-0.009325945,
0.014719657,
-0.019254832,
-0.010892284,
-0.008002093,
0.0030589493,
0.021863213,
-0.028836371,
-0.011390367,
0.000990431,
0.016449839,
0.021129197,
0.022256436,
0.01342202,
-0.02177146,
0.04005634,
-0.011691838,
0.008264242,
-0.040292274,
0.0049152905,
0.014942483,
-0.010184482,
0.0052921297,
0.0051250095,
0.01460169,
0.022610337,
0.028705297,
-0.043359417,
0.028731512,
-0.025035214,
0.011639408,
0.00051405746,
0.0029983274,
0.0039518937,
0.031169496,
0.0035062407,
0.00089294446,
0.015860004,
0.007818589,
-0.021889428,
-0.012032632,
0.018520815,
0.011953987,
-0.02525804,
-0.006638919,
-0.023042882,
-0.011527995,
-0.0021070212,
0.019451443,
-0.0021545356,
0.0056165387,
0.0055772164,
-0.0002113575,
0.022190899,
0.005111902,
-0.024039049,
-0.020932585,
-0.0010019001,
0.016213905,
0.0036274844,
-0.0013926657,
0.018612567,
-0.0067241173,
0.0011083981,
0.008834416,
0.023855545,
0.018468386,
0.011586978,
0.02249237,
-0.009673292,
-0.016423624,
-0.018166915,
0.01895336,
0.034839578,
0.013461342,
0.020159245,
0.007962771,
0.015204633,
-0.005452696,
0.0061670514,
-0.0030442034,
-0.0014500107,
0.0064292,
-0.0062784646,
0.031536505,
0.011757375,
0.041445732,
0.017498435,
0.0034013812,
-0.009620862,
-0.00034570877,
-0.004784216,
-0.0010674372,
-0.0016941369,
0.022584122,
-0.0015253786,
-0.035127945,
-0.00023757239,
-0.0130353505,
-0.03177244,
0.0049578897,
0.02376379,
0.037225135,
0.0025723353,
0.032925893,
0.0016507184,
0.0009887926,
-0.022505477,
0.027918851,
0.008395316,
-0.0007327879,
-0.01229478,
0.0024347072,
0.0069338367,
0.0017432898,
0.038457233,
0.0024707527,
0.0052790223,
0.019805344,
-0.007949663,
-0.02899366,
-0.021286486,
0.02198118,
-0.017406682,
0.01521774,
-0.012891169,
-0.0037946044,
0.017341144,
0.008618142,
0.00060048467,
0.021640386,
0.0044761915,
0.013828351,
0.009647077,
0.008146275,
0.0018415955,
0.0074515804,
-0.02705376,
0.008002093,
0.0034636415,
0.0026853872,
0.005790212,
-0.021954965,
-0.007884126,
0.034970656,
-0.0036700836,
0.011967095,
-0.019910203,
-0.016423624,
-0.033214256,
0.029780107,
0.0053871586,
0.013028797,
0.020119922,
0.0018170191,
0.00020920705,
0.012419301,
-0.029308239,
0.019962633,
0.02434052,
0.03182487,
-0.01336959,
0.0077333907,
0.010440078,
0.015860004,
0.02587409,
0.0020447609,
-0.014365756,
-0.0065569975,
-0.004898906,
0.0065111215,
-0.017236285,
0.043175913,
0.053399716,
-0.002136513,
-0.0029393437,
-0.0017662278,
0.015453674,
0.010256573,
-0.011777036,
-0.0075957626,
0.026293527,
-0.012406194,
0.012262012,
0.009548771,
-0.00078276003,
0.011593532,
0.0037028522,
0.016554698,
0.007025589,
0.007372936,
0.021587957,
0.002007077,
0.0052691917,
0.020460716,
-0.041052505,
0.020303426,
0.012144045,
0.028574223,
-0.02356718,
0.025022106,
0.0072811837,
-0.029649032,
-0.00981092,
0.02388176,
-0.0034374266,
0.007418812,
-0.0056165387,
-0.016318765,
0.0034407035,
-0.018586352,
-0.005216762,
-0.0056230924,
0.007209093,
-0.0051774397,
0.017563973,
-0.02064422,
-0.0053380057,
-0.018835394,
0.005632923,
0.03525902,
0.006150667,
-0.0044335923,
0.018664997,
0.01762951,
0.02080151,
0.02136513,
-0.021732138,
-0.0071435557,
0.009574986,
-0.0060720225,
0.0036307613,
-0.008257688,
-0.014745872,
0.013671062,
-0.00462365,
-0.013671062,
-0.028338289,
-0.016528483,
0.010518722,
0.0049578897,
-0.015742037,
0.024720635,
0.000098459415,
-0.016961029,
-0.024707528,
0.010866069,
0.02090637,
-0.009817474,
-0.0091948705,
0.016974136,
-0.010256573,
-0.014680334,
-0.025402222,
-0.015453674,
-0.0105121685,
0.0034013812,
-0.020722866,
0.011947433,
-0.0056919064,
0.0044794683,
-0.017616402,
-0.00015104278,
-0.0008298649,
0.01916308,
0.019372799,
0.01042697,
0.014680334,
0.02335746,
0.015977971,
-0.005154501,
-0.0016728372,
0.023121526,
0.01093816,
-0.0031015484,
0.021758353,
0.00681587,
-0.011914664,
-0.045509037,
0.0070321425,
-0.024930354,
0.0431497,
-0.007464688,
-0.05117145,
-0.03919125,
0.006406262,
-0.0022970792,
0.009686399,
0.0042107655,
-0.0015909157,
-0.029072305,
0.0008724641,
-0.0005095518,
-0.010800532,
0.047344077,
-0.02458956,
0.011685284,
-0.0037749433,
-0.0088933995,
-0.019084435,
-0.015964864,
0.00088065624,
-0.022479262,
0.0010150075,
-0.029911181,
-0.016122153,
-0.009024474,
-0.015257062,
0.018874716,
0.026568783,
0.027761562,
-0.008565713,
0.025729908,
0.0075761015,
0.0017989964,
-0.0023740854,
-0.005885241,
0.009155548,
-0.016764417,
0.0375135,
0.027682917,
0.010053407,
-0.007975878,
-0.038090225,
0.0026673644,
0.008329779,
-0.015873112,
-0.015466781,
-0.013946318,
-0.033922058,
0.00040817392,
0.01793098,
-0.017550865,
0.00039465688,
-0.026922684,
-0.020277211,
0.00986335,
-0.0018366802,
-0.010243465,
-0.03950583,
0.007320506,
-0.023580287,
0.013500664,
-0.008146275,
-0.0045024063,
0.0076416386,
-0.010984036,
-0.0020808063,
0.004037092,
-0.012419301,
-0.020985015,
0.0055739395,
0.018324204,
0.0069403904,
-0.004784216,
-0.013815244,
-0.0301209,
-0.014077392,
-0.005488741,
-0.021378238,
0.010361433,
-0.014287111,
-0.0076940684,
-0.030514125,
-0.0060261465,
0.017773692,
-0.027184835,
0.01506045,
-0.011744267,
-0.020945692,
0.0028459532,
-0.027184835,
0.012091615,
-0.032244306,
0.009398036,
0.0030720567,
-0.026411494,
-0.022020502,
-0.0022446495,
0.024930354,
-0.005967163,
0.022938022,
0.010453185,
-0.02295113,
-0.0080152005,
-0.024655098,
0.032139447,
-0.032952107,
-0.037828077,
0.043359417,
0.011049573,
0.008546052,
0.0035881621,
-0.0010772678,
-0.027289694,
0.0010174651,
-0.024497809,
-0.028810157,
-0.0012894445,
-0.041786525,
-0.024497809,
0.02479928,
-0.013605525,
0.013015689,
-0.0020234613,
-0.037880506,
-0.0005398627,
-0.020919478,
0.009411143,
0.03232295,
0.014234682,
0.021234056,
0.007071465,
-0.012956706,
-0.008205258,
-0.0015425821,
-0.002185666,
-0.0033653355,
-0.03248024,
0.04217975,
0.015021128,
0.0030573108,
0.0301209,
0.008008647,
-0.01634498,
-0.010446631,
-0.0123865325,
-0.029937396,
-0.020775296,
-0.0075695477,
0.020342749,
0.016423624,
-0.027761562,
0.0017563972,
-0.027132405,
-0.0056624147,
-0.020447608,
-0.009011366,
0.025428437,
-0.03182487,
-0.021299593,
-0.008768879,
0.0058721337,
0.0070976797,
0.0063669397,
-0.0033620587,
0.0026214884,
0.034603644,
-0.0184946,
0.021102982,
0.005793489,
0.004833369,
-0.018809179,
0.015021128,
-0.03596682,
-0.023436105,
0.0061703282,
-0.0045482824,
-0.054893967,
-0.024510916,
-0.009653631,
0.015034235,
-0.005937671,
0.0030261807,
0.046478987,
-0.002136513,
-0.0013172979,
-0.0063669397,
0.004882522,
0.029832536,
-0.031090852,
0.004833369,
0.013251623,
-0.0038142656,
-0.0013762814,
-0.000077927834,
0.024838602,
0.020421393,
0.0072680763,
-0.0040436457,
-0.003286691,
0.020762188,
-0.0152308475,
-0.042205963,
-0.03693677,
-0.007975878,
-0.021784568,
0.018717427,
0.0045187906,
-0.02915095,
-0.005357667,
-0.008611589,
-0.022911808,
0.00975849,
-0.011488672,
0.0035947158,
0.01506045,
0.0043483935,
-0.016253227,
0.0049873814,
-0.014667227,
0.038352374,
0.00013445367,
0.00535439,
-0.013697277,
-0.00018678105,
-0.03478715,
-0.012635574,
-0.014234682,
0.03043548,
-0.0024003002,
-0.0030753335,
0.017695047,
0.013671062,
-0.020460716,
0.016148368,
-0.010807086,
-0.012189921,
-0.0041386746,
-0.0153226,
0.0241308,
-0.005937671,
-0.024825495,
-0.029386884,
0.02474685,
-0.011344491,
0.0063538323,
0.011475565,
0.012635574,
0.0021807505,
-0.030251976,
0.0025919967,
0.005170886,
-0.012792863,
0.0008437915,
-0.023042882,
-0.010617028,
0.026293527,
0.0001303576,
-0.0052462537,
-0.008198705,
0.012707665,
0.009568432,
-0.016816847,
-0.027499413,
-0.015335707,
0.0061408365,
-0.012229243,
-0.0022593953,
0.0149555905,
-0.007530225,
0.021129197,
0.021352023,
-0.005881964,
-0.014339541,
0.0007983251,
0.012006417,
0.0025362899,
-0.009417697,
0.0073598283,
-0.005845919,
0.014890053,
0.0134744495,
-0.012720772,
-0.015099773,
-0.001969393,
-0.009902672,
0.0027247095,
0.01613526,
-0.003683191,
0.013231962,
0.011423135,
0.03410556,
-0.03811644,
-0.009869903,
-0.003476749,
0.0073270597,
0.0032227922,
-0.024628883,
0.0092866225,
-0.012327549,
-0.01675131,
0.009378375,
-0.038693167,
0.0060425308,
0.041471947,
0.19115894,
-0.016685773,
-0.002677195,
-0.005023427,
-0.014339541,
-0.0075171175,
-0.005039811,
-0.0062358654,
-0.0204345,
0.030042255,
0.017668832,
0.0014115076,
-0.034341495,
0.005154501,
0.009063796,
-0.01675131,
-0.03365991,
-0.01363174,
0.017996518,
-0.012314442,
-0.004584328,
0.0099354405,
0.022780733,
0.0006430838,
0.04223218,
0.0084084235,
-0.015820682,
-0.0068879607,
0.03688434,
0.0053216214,
-0.005721398,
-0.009188317,
-0.006688072,
0.017563973,
0.001298456,
-0.0060752993,
-0.015768252,
0.005311791,
0.0048661376,
-0.013553095,
-0.0104662925,
-0.012281673,
-0.017380467,
-0.0042599184,
-0.0052036545,
0.02582166,
-0.0015737122,
-0.023095312,
-0.03843102,
-0.0031244864,
-0.041524377,
0.007877572,
0.0075498866,
0.00998787,
0.0024625605,
-0.0037192365,
0.0071959854,
0.00023060905,
0.013179532,
0.010007531,
-0.008198705,
-0.010715334,
-0.018363526,
0.014418186,
-0.035783317,
0.04113115,
-0.01588622,
-0.015021128,
0.004535175,
-0.007582655,
-0.010807086,
-0.03887667,
-0.020159245,
-0.0013721853,
0.027079975,
-0.014719657,
0.0018923869,
0.015178418,
0.0061408365,
0.0052528074,
0.003519348,
-0.018940253,
-0.026031379,
0.007300845,
-0.024864817,
-0.040397134,
0.009594647,
0.009083457,
-0.0074253655,
0.00035492494,
0.0053609437,
-0.022479262,
-0.02423566,
-0.024039049,
0.03308318,
0.012950152,
0.000997804,
0.0018907485,
-0.0007962771,
-0.0015302938,
-0.02233508,
0.081738,
-0.007418812,
0.022243328,
0.0062751877,
-0.004443423,
-0.02187632,
0.026699858,
0.008205258,
-0.012327549,
0.01053183,
-0.010184482,
-0.011521441,
-0.0197267,
-0.0037683893,
0.032008372,
-0.0013795582,
-0.011921219,
0.0053445594,
-0.011265846,
-0.019503873,
-0.008146275,
0.012602805,
0.025572618,
0.006058915,
-0.014837624,
-0.010649797,
-0.01150178,
-0.01583379,
-0.033790983,
0.009607755,
-0.028888801,
-0.016725095,
0.00029020695,
0.028049925,
0.017668832,
-0.0044958526,
0.0049841045,
-8.2561525e-7,
0.034760933,
0.011174094,
-0.0009773236,
0.02330503,
0.0048890756,
0.012570037,
-0.008218366,
0.014064285,
0.0059475014,
-0.012012971,
0.02101123,
-0.017511543,
-0.014182252,
-0.0047285096,
-0.0021184902,
0.014523045,
-0.020015063,
0.0052102082,
-0.024261875,
-0.016423624,
0.0011198671,
-0.027237264,
0.01875675,
0.0058065965,
-0.009961655,
0.0139594255,
0.011737714,
-0.16462946,
0.017708154,
0.012851846,
-0.0022905255,
0.009699507,
-0.000681587,
0.014221574,
0.0146541195,
-0.0030589493,
0.0009060519,
0.03811644,
-0.007038696,
0.0063702166,
-0.011416581,
0.02444538,
-0.00089212524,
-0.019648055,
0.024327412,
0.009640523,
0.017459111,
0.03145786,
-0.025349792,
0.0040272614,
-0.030854918,
0.0067437785,
-0.003430873,
0.01618769,
-0.005931117,
0.0021184902,
-0.021601064,
-0.025978949,
-0.0067241173,
0.04097386,
0.006058915,
-0.012150599,
-0.004921844,
-0.021129197,
-0.02136513,
0.010911945,
0.020500038,
0.041104935,
0.04933641,
-0.00019169634,
-0.014575475,
-0.03156272,
0.0042042118,
0.012497946,
-0.00094291655,
0.014011855,
0.0019038559,
0.005236423,
-0.0015712546,
0.0048726914,
0.009044135,
0.014391971,
0.018101377,
-0.0073532746,
0.015073557,
0.0018514261,
0.0024920523,
-0.031693794,
0.0009986232,
0.016371194,
0.011698391,
0.018022733,
-0.018861609,
-0.0034177655,
0.0029426205,
-0.008539498,
0.032060802,
-0.024366735,
-0.003971555,
-0.0032883293,
-0.005216762,
0.04852375,
0.011763928,
-0.0130353505,
-0.00059884624,
0.0066323653,
-0.00699282,
-0.008329779,
0.005472357,
-0.024995891,
-0.02090637,
-0.0075695477,
0.014300219,
0.0024134077,
-0.022911808,
-0.0016777525,
-0.020696651,
0.0014614797,
-0.05153846,
0.0014024962,
-0.011174094,
-0.0054821875,
0.033266686,
-0.003925679,
-0.019490765,
0.013972533,
0.0055968775,
0.0102369115,
-0.011770482,
-0.007464688,
-0.018507708,
0.046845995,
-0.015991079,
-0.010610474,
-0.0065176752,
0.040397134,
-0.01865189,
0.016436731,
0.015742037,
0.0003153978,
0.016371194,
-0.013867673,
-0.0052397,
0.011318276,
-0.016279442,
-0.0025067981,
-0.061814696,
0.06946944,
0.01104302,
0.0030179885,
0.032008372,
0.01624012,
0.01403807,
-0.11178026,
-0.015991079,
-0.012255458,
0.018887823,
-0.0011829466,
0.017603295,
-0.01268145,
0.024681313,
0.0005144671,
0.027892636,
-0.0118098045,
-0.02177146,
-0.006642196,
0.004177997,
0.03263753,
-0.004649865,
0.02807614,
-0.014365756,
-0.026359065,
0.027368339,
-0.013749707,
-0.0100271925,
0.002292164,
-0.013749707,
-0.026948899,
0.0003731525,
-0.015401244,
0.006901068,
0.008972044,
0.008257688,
0.029413098,
0.015794467,
-0.004128844,
-0.0018514261,
-0.023894867,
-0.008696787,
0.012425855,
-0.030933563,
0.04758001,
-0.020683544,
0.0071697705,
0.007864465,
0.030514125,
-0.0061637745,
-0.00006446199,
0.00614739,
-0.036962986,
0.017249392,
-0.0033129058,
-0.014772086,
-0.013920103,
-0.024707528,
-0.013415466,
0.009974763,
0.019648055,
-0.017196963,
0.0031375939,
-0.0065176752,
-0.012524161,
-0.010662904,
0.0033112674,
-0.0015450397,
-0.007864465,
0.0136579545,
0.0065602744,
-0.025978949,
-0.017498435,
-0.020880155,
0.010459739,
-0.018232452,
0.0010805447,
-0.028757727,
-0.028652867,
-0.006383324,
-0.02797128,
0.009483234,
-0.026922684,
-0.0033981043,
0.012425855,
-0.027446983,
-0.014981805,
-0.0010051769,
0.040869,
-0.0061211754,
-0.017668832,
0.023685146,
0.027473198,
-0.009719168,
0.00034427515,
0.00010250429,
0.003427596,
0.035180375,
-0.002737817,
-0.012458623,
0.003660253,
-0.0015622432,
0.0037618356,
-0.008945829,
0.0019186018,
-0.0043320092,
0.0020267381,
-0.01194088,
-0.049834494,
0.02458956,
-0.0010797255,
-0.0084542995,
-0.0018170191,
-0.014523045,
0.035180375,
-0.014758979,
0.007680961,
-0.0040010465,
-0.03324047,
0.015807575,
-0.0052069314,
0.0047514476,
-0.0076875146,
0.03130057,
0.027315909,
0.019779129,
0.03843102,
0.026398387,
0.010250019,
0.037565928,
-0.010970929,
0.03633383,
0.022728303,
-0.021338915,
0.00010567875,
0.006078576,
-0.0086640185,
-0.003430873,
0.017459111,
-0.031353,
0.006855192,
0.0006320244,
0.008054523,
0.0014074115,
-0.008906507,
0.028810157,
0.0014385417,
0.026136238,
-0.006153944,
-0.0253629,
0.018114485,
-0.008493622,
-0.004482745,
0.001138709,
-0.034918223,
0.016502269,
0.003249007,
-0.024104586,
-0.0003852359,
-0.008775433,
-0.0065340595,
-0.019228617,
-0.03520659,
0.021207841,
0.0108136395,
-0.017419789,
-0.0029721123,
-0.022308866,
0.013395805,
0.011429689,
-0.00097240834,
-0.024773065,
0.016607128,
-0.016816847,
-0.020408286,
0.016738202,
0.0119015565,
-0.034760933,
-0.022715196,
0.011390367,
-0.0036536993,
0.022125361,
-0.004200935,
0.0020349303,
-0.0055772164,
0.014208467,
-0.0050299806,
0.004515514,
0.002418323,
-0.014077392,
-0.039872836,
0.008913061,
0.0013140211,
0.0056493073,
-0.005154501,
0.029989826,
0.0040501994,
0.0048268153,
-0.017341144,
0.025022106,
-0.019084435,
0.01398564,
0.020041278,
0.03806401,
-0.0027509243,
-0.008913061,
0.013749707,
0.014182252,
-0.020316534,
0.0013910272,
-0.025690585,
-0.021430667,
-0.0003244092,
0.012930491,
-0.013671062,
-0.028207215,
-0.018730534,
0.00462365,
0.02305599,
0.018717427,
0.0099354405,
0.013841459,
-0.009745383,
-0.004584328,
-0.008919614,
-0.0027329016,
-0.013179532,
0.0028852755,
0.004482745,
0.020840833,
-0.02638528,
0.01962184,
0.00074548577,
0.013762814,
0.016109046,
-0.014103607,
0.025271147,
-0.009142441,
0.03166758,
0.010230358,
-0.022321973,
0.010800532,
0.0021627278,
-0.014208467,
0.0015876389,
0.0043221787,
-0.009109672,
0.05851162,
-0.005773828,
-0.024733743,
-0.012740433,
0.007228754,
0.020565575,
-0.0009715891,
0.003660253,
0.005265915,
-0.015401244,
-0.015296385,
-0.020932585,
0.02684404,
-0.0465052,
-0.023698254,
0.010931606,
0.012864954,
0.008880292,
0.019333476,
-0.025992056,
0.00045425477,
-0.016895492,
0.008434638,
0.0070059276,
-0.028915016,
-0.009496341,
0.04411965,
-0.018415956,
0.0047711087,
-0.0022593953,
-0.012825632,
0.0060458076,
-0.012799417,
-0.0052954066,
0.02689647,
-0.012773202,
0.010544937,
-0.027184835,
-0.0068289773,
-0.017078996,
-0.015650285,
0.014182252,
-0.007707176,
-0.02381622,
-0.0046596956,
-0.021679709,
-0.0012706026,
-0.004928398,
-0.030225761
] |
CONTEXT Limited information exists regarding the role of left ventricular function in predicting exercise capacity and impact on age- and sex-related differences. OBJECTIVES To determine the impact of measures of cardiac function assessed by echocardiography on exercise capacity and to determine if these associations are modified by sex or advancing age. DESIGN Cross-sectional study of patients undergoing exercise echocardiography with routine measurements of left ventricular systolic and diastolic function by 2-dimensional and Doppler techniques. Analyses were conducted to determine the strongest correlates of exercise capacity and the age and sex interactions of these variables with exercise capacity. SETTING Large tertiary referral center in Rochester | [
-0.022044547,
-0.000659028,
0.014283109,
-0.023245567,
-0.01840274,
0.0380969,
-0.010996445,
0.0049719685,
-0.02143758,
-0.012959404,
-0.01925508,
0.0140377395,
-0.0048589692,
-0.00206143,
-0.019087194,
-0.0032027226,
0.0380969,
-0.02386545,
-0.0077872653,
-0.024369104,
0.0006041426,
0.02223826,
-0.0056854784,
-0.005423966,
-0.034635894,
0.003861347,
0.021360094,
-0.033861045,
0.0007369168,
-0.0064538736,
0.009750224,
0.0031978798,
-0.0433659,
-0.028075479,
-0.017098406,
-0.013779456,
-0.02383962,
0.008174691,
0.021127637,
-0.015884472,
0.029160272,
-0.010466962,
-0.02002993,
-0.00016021685,
0.010680047,
0.026809888,
0.012339522,
-0.022741914,
-0.013508257,
0.022612771,
0.0031526801,
0.0035062064,
-0.000076375414,
0.022070374,
-0.010118279,
-0.022005804,
-0.00889143,
0.016698066,
0.0043294868,
-0.022754828,
-0.012481579,
-0.012539692,
-0.00790995,
0.01649144,
-0.023762135,
0.0054820795,
0.0033254076,
0.0203657,
0.03249214,
0.024924414,
0.008839773,
0.015458303,
0.012068324,
0.044760633,
0.02002993,
-0.014825506,
-0.032233853,
-0.03329282,
0.015251675,
0.0106154755,
0.0029783384,
-0.026215835,
-0.022754828,
0.023981677,
0.007516067,
0.00820052,
0.009853538,
0.008865601,
-0.025208527,
0.010053708,
-0.0009992366,
0.0014019983,
0.004716913,
-0.0019322878,
-0.02362008,
-0.014735107,
0.01047342,
0.005611222,
0.008284462,
-0.012662377,
-0.005136625,
-0.007651666,
-0.029521871,
-0.003567549,
-0.03225968,
-0.013469515,
-0.027223142,
-0.00962754,
0.02012033,
-0.006831614,
-0.009407998,
0.03225968,
0.0016610895,
0.002923453,
0.017369604,
-0.01962959,
-0.021463407,
0.000573875,
-0.009885823,
0.0045425715,
0.0203657,
-0.009479026,
0.048273295,
-0.019668333,
-0.0024940558,
-0.016271897,
-0.034635894,
0.003233394,
0.0026054408,
0.011222444,
-0.039052553,
0.00085637317,
-0.0022357716,
0.014941734,
-0.026551604,
-0.0043036584,
0.0028330535,
0.017886173,
-0.011416157,
-0.028798675,
-0.0056499643,
0.015587444,
-0.02174752,
-0.035307433,
-0.024498245,
0.0043262583,
0.029986782,
0.011170787,
0.023051854,
0.0014972405,
-0.026861545,
0.0013043346,
0.013482429,
0.0032769793,
0.0013987698,
0.0058727344,
-0.01664641,
0.01876434,
-0.006040619,
-0.006896185,
-0.026422461,
0.023387624,
0.018105714,
-0.013998997,
0.022354487,
0.011584041,
0.0035191206,
-0.020159073,
0.010363649,
-0.0051947385,
-0.017162977,
0.030167582,
-0.015200018,
0.009769595,
0.022341574,
0.014812592,
0.026370805,
-0.005530508,
-0.035178293,
-0.027817195,
-0.008775202,
0.030167582,
0.014347681,
-0.000729249,
-0.0064635593,
0.040163174,
0.022341574,
-0.021760434,
0.002818525,
-0.028617876,
-0.011874611,
0.022987284,
-0.024252875,
0.0042197164,
-0.63765174,
0.008994743,
-0.007593552,
-0.010331363,
0.017317947,
0.005982505,
0.0076839514,
0.025221441,
0.0028104538,
0.035126634,
-0.005753278,
0.022651514,
-0.0050946535,
-0.030270895,
-0.012068324,
-0.023607165,
0.005349709,
-0.007722694,
0.016723894,
-0.011861697,
-0.016284812,
0.015342074,
0.0040841172,
0.007522524,
0.0088204015,
0.04331424,
0.03404184,
0.013430772,
0.003674091,
0.0039065466,
0.017614974,
0.03711542,
-0.0073417253,
0.021282608,
0.044373207,
-0.016181499,
-0.0025650838,
-0.00012934383,
-0.013353287,
0.02319391,
-0.00033133005,
0.011629241,
0.011299929,
-0.0009790581,
-0.009556511,
0.017460003,
0.0008010842,
-0.0011566284,
-0.007335268,
-0.01778286,
-0.019422963,
-0.027481427,
0.018712683,
0.016168583,
-0.0017305034,
-0.023568423,
0.005924391,
-0.015497045,
-0.015122533,
0.015949043,
0.018777253,
0.018467313,
-0.012313694,
0.005320652,
0.0019419735,
0.03494584,
-0.013727799,
-0.0052076527,
0.002876639,
-0.033938527,
0.002513427,
0.01993953,
0.015109619,
-0.011751926,
0.025350584,
-0.004652342,
0.016853036,
-0.010486334,
-0.03520412,
-0.008768745,
0.010705875,
0.033137847,
0.0019355164,
0.013237059,
0.011248272,
0.007277154,
-0.014864249,
0.02101141,
-0.001775703,
-0.0035933773,
0.023400538,
0.021050153,
-0.012604264,
-0.033189505,
-0.0075741806,
0.0344551,
-0.026784059,
0.013921512,
0.016659323,
-0.034610067,
-0.016840123,
0.030709978,
0.0019177593,
0.021127637,
0.014644708,
0.02205746,
-0.009905195,
-0.014283109,
0.05157933,
-0.038794268,
0.005223796,
-0.023155168,
-0.03406767,
0.020042844,
-0.019836217,
-0.034506753,
-0.00012793133,
0.0014665693,
0.012087695,
-0.033706073,
0.010680047,
-0.00933697,
0.03262128,
-0.027429769,
-0.007638752,
0.009801881,
-0.011868154,
0.0022357716,
-0.014489737,
-0.020559413,
0.009924566,
-0.009285313,
0.03034838,
-0.014709279,
0.018712683,
0.00501394,
0.019435877,
0.014631793,
-0.0009572654,
-0.024382018,
-0.030400036,
-0.0113645,
0.0020372157,
-0.005401366,
-0.028411249,
-0.013779456,
0.003322179,
-0.017253377,
-0.0010339435,
0.0067541287,
-0.032414652,
-0.030761635,
-0.013521172,
0.020004103,
-0.007838922,
-0.01711132,
-0.0012849633,
-0.018880567,
-0.014941734,
-0.029754326,
0.0027248971,
0.0029718813,
-0.015316246,
0.006521673,
-0.011177244,
-0.022160774,
-0.022716084,
-0.01778286,
-0.0043908292,
-0.031407345,
0.011293472,
0.012087695,
-0.005582165,
-0.0026861546,
-0.006402217,
0.0034384069,
-0.008394233,
-0.02094684,
-0.017317947,
-0.014748021,
0.03440344,
-0.011739012,
-0.00046612206,
0.013456601,
0.025880065,
0.02067564,
0.027094001,
0.010835017,
-0.009272398,
0.00998268,
0.007703323,
0.015626187,
-0.019862046,
-0.00018453188,
0.01107393,
0.00432303,
0.0054271943,
-0.007580638,
0.010938331,
0.013133746,
0.03494584,
-0.007645209,
0.0159103,
-0.006838071,
0.010240964,
-0.0023697566,
0.0076064663,
0.010763989,
0.008342576,
0.0017159749,
-0.0073158965,
-0.01722755,
0.0003228551,
-0.016723894,
-0.017808687,
0.0064958446,
0.01802823,
0.007283611,
0.00087493734,
0.016013613,
0.016297726,
-0.0029492814,
0.031536486,
0.0064474163,
-0.027248971,
0.0065894728,
-0.019022623,
0.016530182,
-0.0059211627,
-0.033525273,
-0.002326171,
0.0079228645,
0.008768745,
0.030761635,
0.009479026,
0.046930216,
0.0115904985,
0.017524576,
0.020636898,
0.0077485223,
0.009498397,
0.02232866,
0.014644708,
-0.017421262,
0.0114678135,
-0.019616676,
0.022134947,
0.025131041,
-0.0068186997,
-0.011241815,
0.012726949,
-0.011687355,
-0.018144457,
-0.028230451,
-0.009989137,
0.014166882,
0.0029751097,
-0.011855239,
-0.00114775,
0.018945137,
0.033060364,
0.010073079,
0.0133016305,
0.006637901,
-0.0009233656,
0.00051697175,
0.01033782,
-0.012791519,
-0.01111913,
-0.012287865,
-0.010996445,
-0.006234332,
-0.0098793665,
-0.028669532,
0.01916468,
0.007826008,
0.015548701,
-0.010098908,
0.009963308,
0.02230283,
0.0058372202,
-0.028747018,
0.007102812,
0.020972667,
0.01053799,
-0.008097206,
-0.0046200566,
0.0032963506,
-0.019022623,
0.0159103,
0.0065410445,
-0.0022196288,
0.0061859037,
-0.019422963,
-0.011771297,
0.008368405,
0.005643507,
-0.005114025,
0.010402392,
-0.008826858,
-0.003935604,
0.012391179,
-0.007980978,
-0.012533235,
0.030193409,
0.01944879,
-0.013818199,
0.0011356429,
0.026215835,
0.006344103,
0.00041164027,
-0.015987786,
-0.015225846,
0.013947341,
0.0069736703,
0.027636398,
-0.016039442,
-0.008568575,
0.020197816,
0.005753278,
-0.025143955,
-0.044347376,
-0.021308437,
-0.016969264,
0.043055955,
0.009698567,
0.009685653,
0.003638577,
-0.012565521,
-0.007645209,
0.0037160623,
-0.021644207,
0.036521368,
0.02457573,
0.018970966,
-0.0021469865,
0.02043027,
-0.01181004,
-0.012391179,
0.011338672,
0.016026527,
-0.0048299124,
-0.011642155,
-0.0074966955,
0.0016578609,
0.0157295,
0.031562313,
0.040628087,
0.020507757,
-0.00081399846,
0.0077614365,
0.008626688,
0.0140377395,
0.000055339384,
-0.028333765,
0.02362008,
0.002009773,
0.01873851,
-0.0248211,
0.007780808,
-0.0050010257,
-0.006334417,
0.029935125,
0.0028217535,
0.027558912,
0.022509458,
0.015122533,
0.0077485223,
-0.0009516154,
-0.009769595,
0.009814795,
0.021450493,
0.026887374,
-0.011403242,
0.045148056,
-0.0074321246,
-0.017214634,
-0.017563317,
0.0035417206,
-0.0036837768,
0.009769595,
0.005336795,
-0.013482429,
-0.011926267,
-0.008478175,
-0.0019468163,
0.023762135,
-0.0069865845,
0.0044328007,
-0.008633145,
-0.04122214,
-0.025621781,
-0.012643006,
0.007322354,
-0.020378614,
0.0004564364,
-0.013224145,
0.025376411,
0.018996794,
0.0039291466,
0.025595952,
-0.01738252,
0.0054497942,
-0.006415131,
-0.016013613,
-0.00013307684,
-0.010525077,
-0.02288397,
-0.0047782557,
-0.002402042,
-0.03357693,
-0.03623726,
0.0053626234,
0.013727799,
0.01671098,
-0.0064829304,
0.026099607,
0.00432303,
0.0071802977,
0.025079384,
0.009898737,
0.01738252,
0.01098353,
-0.01784743,
0.0032527652,
-0.025040641,
0.024640301,
-0.01987496,
-0.017589146,
-0.0023035712,
-0.01615567,
0.0091368,
0.036960453,
-0.012797976,
0.0148513345,
-0.008239262,
0.01824777,
0.00046854347,
0.026125435,
0.027171485,
-0.0017660174,
0.0056047644,
0.028592048,
-0.0065894728,
-0.014915906,
-0.016207326,
0.024097905,
-0.014683451,
-0.030270895,
0.01840274,
-0.014218539,
-0.025763838,
-0.033034533,
0.043908294,
0.022741914,
0.013986083,
-0.008768745,
-0.041996993,
-0.053619776,
0.012371807,
-0.0066637294,
0.009976223,
0.0019306735,
-0.0039420607,
-0.0057726493,
0.0007974521,
-0.005068825,
-0.01889348,
0.07743357,
-0.03324116,
-0.022367401,
-0.00027523396,
-0.028075479,
-0.0014149125,
-0.023904191,
0.01944879,
-0.009356341,
0.01310146,
-0.022845227,
-0.04850575,
-0.0059082485,
-0.009498397,
0.014476823,
0.013088546,
0.021050153,
0.010189307,
-0.0064183595,
0.015949043,
-0.032182198,
0.012029581,
-0.00035715845,
0.0032237081,
0.014128139,
0.043469213,
0.013011061,
0.007793722,
0.0043488583,
-0.026125435,
-0.010247421,
0.014541394,
-0.016258983,
-0.010085993,
-0.026112521,
-0.034635894,
-0.008762288,
0.006292446,
0.008013263,
-0.0050752824,
-0.04721433,
-0.009395083,
0.026732402,
0.0013164417,
0.0046491134,
-0.020391528,
0.002555398,
-0.013818199,
0.026422461,
0.0051592244,
0.002009773,
0.0025537838,
-0.01971999,
-0.014166882,
0.0062311036,
-0.003954975,
-0.007961607,
0.021515064,
0.0089043435,
0.006967213,
-0.011855239,
-0.0031898085,
-0.02190249,
0.03213054,
0.022096204,
-0.030167582,
0.002127615,
-0.0066314437,
-0.024149561,
-0.014709279,
0.013482429,
0.029960955,
-0.00933697,
0.01720172,
-0.009898737,
0.022690257,
0.0016804609,
-0.009072228,
0.018376913,
-0.016362296,
0.034145154,
-0.005097882,
-0.011106215,
-0.0016409111,
-0.012139352,
0.012662377,
0.027739711,
0.022574028,
0.011868154,
-0.031768944,
0.015264589,
0.012830262,
0.025221441,
-0.020753127,
-0.0030316093,
0.010989988,
-0.0045619425,
-0.011358042,
-0.008284462,
-0.002326171,
-0.032078885,
0.004313344,
-0.022819398,
-0.016594753,
-0.0036579482,
-0.014735107,
0.0046620276,
0.029444385,
-0.019926617,
0.007671037,
0.015006306,
-0.0085362885,
0.0062504746,
0.0015303332,
-0.01379237,
0.0096339965,
0.008077835,
0.021618377,
0.009776053,
-0.0055046794,
0.0052819094,
0.012229752,
0.005046225,
-0.009524225,
-0.002671626,
0.033499446,
0.014347681,
-0.004962283,
0.019513363,
-0.020249473,
0.0061729895,
0.0018499597,
-0.009730853,
-0.027223142,
0.0013196702,
0.0034771494,
0.033499446,
-0.014580136,
-0.028049652,
-0.0049396832,
-0.02693903,
-0.006896185,
0.00046612206,
-0.022225345,
0.0113063855,
-0.024407845,
-0.0006368317,
-0.0036805482,
0.01931965,
0.015070876,
0.018970966,
-0.016452696,
0.022122031,
0.009459655,
-0.013998997,
0.019771647,
0.010234507,
-0.021450493,
-0.023658821,
0.020985581,
-0.03293122,
0.007935778,
-0.011822954,
-0.015406646,
-0.031123232,
-0.029676842,
0.006812243,
0.028695362,
0.00043948652,
0.014709279,
0.0061181043,
-0.0015545473,
0.0007227919,
-0.004913855,
-0.021863747,
0.01713715,
-0.016362296,
-0.016181499,
0.019771647,
-0.04806667,
0.014967563,
-0.0060438477,
0.0033544644,
0.013107917,
0.00042374732,
-0.02297437,
-0.01492882,
0.006524902,
-0.01778286,
-0.006557187,
-0.030322552,
-0.0066766436,
-0.018209027,
-0.0024875987,
0.0061310185,
0.013998997,
-0.0059728194,
-0.00015456688,
0.01606527,
0.009130342,
-0.00944674,
-0.004565171,
0.0067864144,
-0.012694662,
-0.010150565,
-0.007897036,
0.0013721342,
0.027817195,
0.035591546,
-0.019913703,
-0.019526277,
0.0002748304,
-0.05661587,
-0.010008508,
-0.014528479,
0.033706073,
0.011390328,
0.014760936,
-0.0025085842,
0.0052463952,
-0.006089047,
0.014476823,
-0.023180997,
-0.039052553,
0.02165712,
0.00014437677,
0.0079228645,
-0.00049356476,
-0.028282108,
-0.012378265,
0.025221441,
0.01747292,
0.011706726,
0.013237059,
-0.010757532,
0.0022858141,
-0.022289917,
0.021515064,
0.0023197138,
0.014812592,
-0.028566219,
-0.0382777,
-0.0038807183,
0.0126107205,
-0.010699418,
-0.0128948325,
0.029935125,
-0.0015916757,
-0.017150063,
-0.005333566,
-0.009640453,
-0.029547699,
0.008342576,
-0.021644207,
0.0180024,
0.010060165,
-0.0012494492,
0.03228551,
0.026964858,
0.009362798,
-0.005669336,
0.0040066317,
0.015316246,
0.0054820795,
-0.0041745165,
0.0016271897,
-0.038845927,
-0.012668834,
-0.00944674,
-0.008103663,
0.007257783,
-0.0024004276,
-0.008252176,
-0.021863747,
0.0143605955,
-0.00536908,
0.005114025,
-0.006947842,
0.0056499643,
-0.0105702765,
0.014489737,
-0.0027055258,
0.018196113,
-0.014179796,
-0.009375712,
0.008103663,
-0.028023822,
-0.0051818243,
-0.0106154755,
-0.010809189,
0.00062311033,
0.0049073976,
0.20404443,
-0.008956,
0.008032635,
-0.0075612664,
-0.010389477,
-0.0009879366,
0.023426367,
0.0033124934,
-0.0077549797,
0.006347331,
-0.009194913,
0.01290129,
-0.0046749418,
0.0034190356,
0.015057962,
-0.029108616,
-0.029082788,
-0.008187605,
0.0025828409,
0.0017353462,
-0.014528479,
-0.0052044243,
0.01615567,
-0.011254729,
0.040938027,
-0.010014965,
0.0045974567,
0.019758733,
0.02165712,
0.0036644056,
0.015949043,
-0.024007505,
-0.0053529376,
0.013288716,
-0.005688707,
-0.021463407,
0.019306736,
-0.00043625795,
0.0064119026,
-0.015057962,
-0.0091368,
-0.0148513345,
-0.0041842023,
-0.0069220136,
0.023723394,
0.028101308,
-0.0028088393,
-0.016039442,
-0.013572829,
-0.021308437,
-0.04398578,
-0.015548701,
0.002256757,
0.031149061,
-0.009362798,
0.005020397,
0.03231134,
-0.0057339068,
-0.005023625,
-0.0022712857,
-0.029599356,
-0.014902991,
-0.0030703521,
0.017989486,
-0.021360094,
0.0141152255,
0.0016392968,
-0.018867653,
-0.0057629636,
-0.0005020397,
0.011990839,
-0.028204622,
-0.01907428,
0.0009984294,
-0.005004254,
-0.016091099,
0.027791368,
0.0071867546,
0.002156672,
0.025440982,
0.019371307,
-0.014308938,
-0.01880308,
0.0011727712,
-0.011222444,
-0.030167582,
0.0010500862,
-0.0039388323,
-0.010195764,
-0.01245575,
-0.005572479,
-0.027533084,
-0.005746821,
-0.012920661,
0.02758474,
0.014489737,
0.009918109,
-0.00012934383,
-0.008852687,
0.004591,
0.005643507,
0.07247452,
0.012539692,
0.0032769793,
0.012500949,
-0.013818199,
-0.025247268,
0.028617876,
-0.0030751948,
-0.020688554,
0.015070876,
-0.036159772,
0.0019258307,
-0.02402042,
-0.010454048,
0.018170286,
0.024872757,
-0.016091099,
0.026254578,
-0.008897887,
-0.008768745,
-0.0010476648,
-0.0009895508,
0.023465108,
0.007070527,
-0.036082286,
-0.032182198,
-0.0008075413,
-0.0064958446,
-0.012991689,
-0.005530508,
-0.004048603,
0.015393731,
-0.006502302,
0.038432673,
0.009550054,
-0.013353287,
-0.004113174,
-0.0051850528,
0.01053799,
0.018105714,
-0.008742916,
0.01027325,
0.02012033,
0.012817347,
-0.012869004,
-0.0022503,
0.020688554,
0.0018144457,
-0.013624486,
-0.024394931,
-0.014618879,
0.024239961,
-0.028023822,
0.014915906,
-0.017614974,
0.0030509806,
-0.020740211,
-0.01606527,
-0.025040641,
-0.009227199,
0.029960955,
0.012959404,
0.00067597785,
-0.008587946,
-0.001031522,
-0.160756,
0.01947462,
0.01575533,
-0.01004725,
-0.0038226044,
-0.012888376,
0.042074475,
-0.001019415,
-0.008968915,
0.0097179385,
0.023297224,
-0.00070261344,
-0.020817697,
-0.0045199716,
-0.014696364,
0.022535287,
-0.003551406,
0.0069413846,
0.026654918,
0.01971999,
0.02985764,
-0.013469515,
0.023516767,
-0.012494492,
0.0035804631,
0.0047943983,
-0.0132628875,
0.02021073,
-0.012371807,
-0.011241815,
-0.014541394,
-0.000100539095,
0.0335511,
-0.01842857,
-0.04672359,
0.0054853084,
-0.013049804,
-0.014670536,
-0.00657333,
0.0053626234,
0.0090657715,
0.037502848,
-0.0131402025,
-0.015458303,
0.012907747,
0.0148513345,
0.0098793665,
-0.027688054,
0.0051753675,
-0.014722193,
0.0049881116,
-0.025131041,
0.01704675,
-0.01047342,
-0.0018548026,
-0.0087816585,
-0.020378614,
0.025841322,
0.028979475,
-0.00019502467,
-0.015045048,
-0.009395083,
0.0063053602,
0.027533084,
0.017253377,
-0.029521871,
-0.00249567,
-0.006292446,
-0.033680245,
0.029883469,
0.0090916,
-0.020352786,
-0.0066831005,
-0.011739012,
0.053619776,
-0.009672739,
-0.014283109,
-0.011170787,
0.0061084186,
0.016594753,
-0.011196615,
0.02288397,
-0.030787462,
-0.027145658,
-0.011545299,
0.004468315,
-0.0064732446,
0.01002788,
-0.010357192,
0.008568575,
0.006415131,
-0.054446284,
-0.0012550992,
-0.004019546,
-0.025286011,
-0.0034868352,
0.009872909,
-0.010525077,
-0.001265592,
-0.023813793,
0.009194913,
-0.025918808,
-0.0028378963,
-0.0044198865,
0.019732904,
0.006098733,
0.0001400384,
0.023710478,
0.044812288,
-0.007477324,
-0.013689056,
0.011422614,
0.009872909,
0.041118827,
-0.0061019612,
0.026758231,
0.017330863,
-0.045716282,
0.0036256628,
-0.01965542,
0.05852717,
-0.0029073101,
-0.027429769,
0.044218235,
0.012307237,
-0.015161276,
-0.11343837,
-0.038226046,
-0.0035417206,
0.025273098,
0.03326699,
0.028772848,
0.00027059292,
0.032078885,
0.005779106,
0.03378356,
-0.0043488583,
0.020869354,
-0.0029492814,
-0.01873851,
0.022367401,
-0.0058985627,
-0.0113451285,
-0.017188806,
-0.031045746,
0.03569486,
0.00019764785,
-0.024640301,
-0.0014778692,
-0.019926617,
0.0007744487,
0.003971118,
-0.01673681,
0.030632492,
0.01671098,
0.018815996,
0.0204561,
0.0039420607,
-0.00005735723,
-0.0037483477,
-0.01925508,
-0.0380969,
0.009621082,
-0.026603261,
0.043520868,
-0.021024324,
-0.002689383,
0.019526277,
0.02190249,
-0.014954648,
0.0066637294,
-0.012197466,
-0.036418054,
0.023206824,
-0.009143257,
-0.0031478372,
-0.033809386,
-0.020288214,
-0.024252875,
-0.0015537402,
0.02408499,
-0.012630092,
0.016349383,
0.0019839446,
-0.03471338,
-0.0043617724,
-0.018596454,
-0.0003567549,
-0.018596454,
0.018609367,
0.01018285,
-0.031019919,
-0.030632492,
0.009918109,
0.0066831005,
-0.026228748,
0.006534587,
0.01662058,
-0.007948693,
-0.0035546347,
-0.021230951,
0.015122533,
-0.024317447,
-0.0019904017,
0.014915906,
0.0011122358,
-0.003544949,
-0.008671888,
0.032362998,
-0.008103663,
0.025492638,
-0.003275365,
-0.0067347577,
-0.013934426,
0.007503153,
0.0038096902,
-0.006960756,
0.026073778,
0.018054057,
-0.026383718,
-0.033344474,
0.0068057855,
-0.022431973,
-0.012765691,
-0.022677343,
-0.009149713,
-0.008039092,
-0.0097566815,
-0.05176013,
0.020417357,
0.017460003,
-0.0027975396,
-0.017653717,
-0.011170787,
0.030580835,
-0.0088204015,
0.022470715,
-0.012907747,
-0.01873851,
0.0014988548,
-0.00003362233,
0.013895684,
-0.024046248,
-0.019306736,
0.008013263,
0.015509959,
0.01116433,
0.0077291513,
-0.003819376,
0.0201849,
-0.015045048,
0.02595755,
0.005588622,
-0.011629241,
-0.012914204,
-0.010647762,
-0.025182698,
-0.01624607,
-0.0021292295,
-0.018622283,
-0.011454899,
0.02199289,
-0.0035158922,
-0.013404944,
0.009924566,
0.027171485,
0.0017030607,
0.01815737,
0.0029379814,
-0.017214634,
-0.0039872606,
-0.021088896,
-0.008523375,
0.014515566,
-0.027610568,
-0.0028621105,
-0.0074514956,
-0.011332214,
-0.010215135,
-0.008194063,
-0.010460505,
-0.017524576,
-0.003544949,
0.013973169,
0.0038871753,
-0.020417357,
0.010344277,
0.033525273,
0.020688554,
0.0033318647,
0.0038581186,
-0.007154469,
0.002571541,
-0.022186603,
0.0020646583,
-0.0027507255,
0.0116744405,
0.010376563,
-0.017976573,
0.009743767,
0.0054304227,
-0.00481377,
0.0060955044,
0.0012462207,
0.009311141,
0.022522371,
0.0051753675,
0.01033782,
0.013443687,
0.010215135,
-0.01760206,
0.031562313,
0.04687856,
-0.0004798434,
-0.001787003,
0.043055955,
-0.013075632,
0.0061019612,
-0.0006808207,
0.020197816,
-0.0076258373,
0.0065991585,
0.0045458,
0.02393002,
-0.00093143695,
0.0014625336,
0.010505705,
0.03298288,
-0.0022955,
0.010847932,
-0.01738252,
-0.017589146,
0.010841475,
-0.00657333,
-0.014192711,
-0.029496042,
-0.01913885,
0.023878364,
0.010931874,
0.033809386,
-0.0034836065,
0.00889143,
0.00612779,
0.00042737945,
-0.013482429,
0.007328811,
-0.01071879,
0.0055046794,
-0.006292446,
0.027636398,
-0.0002869375,
0.01270112,
0.016517267,
0.034377612,
0.024498245,
-0.018299427,
0.0039000898,
0.008562118,
0.013340373,
0.004503829,
-0.007645209,
-0.013766542,
0.01981039,
-0.009007658,
0.0072642397,
-0.0021437579,
0.0005641893,
0.08585363,
0.00915617,
-0.0055079083,
0.00568225,
-0.0023067996,
0.009395083,
0.0112289,
0.0072513255,
-0.016091099,
-0.033163678,
0.0049945684,
0.0028879389,
-0.0015093476,
-0.026228748,
-0.014954648,
0.007457953,
0.0024940558,
0.014386424,
0.0024310988,
-0.020623984,
-0.016091099,
-0.041067168,
0.011513013,
0.0016546324,
-0.005446566,
-0.003467464,
0.031097403,
-0.002666783,
-0.012565521,
0.0073675537,
0.02377505,
0.020133244,
-0.03347362,
-0.02061107,
0.030684149,
-0.027765539,
-0.012236209,
-0.026086692,
-0.008265091,
0.007257783,
-0.012720491,
-0.016788466,
-0.010060165,
0.00014346874,
-0.037631992,
-0.005110796,
0.0070317844,
0.0113063855,
-0.043469213
] |
A dynamic population model of Ixodes scapularis, the vector of a number of tick-borne zoonoses in North America, was developed to simulate effects of temperature on tick survival and seasonality. Tick development rates were modelled as temperature-dependent time delays, calculated using mean monthly normal temperature data from specific meteorological stations. Temperature also influenced host-finding success in the model. Using data from stations near endemic populations of I. scapularis, the model reached repeatable, stable, cyclical equilibria with seasonal activity of different instars being very close to that observed in the field. In simulations run using | [
-0.013987924,
0.0009167256,
0.0065589636,
-0.033358958,
-0.010038952,
0.018976815,
-0.015673544,
0.010569107,
-0.007816382,
-0.042222053,
0.0052607646,
0.0025165349,
0.008407707,
0.008652395,
0.0022990357,
-0.009189346,
0.009603954,
0.018569004,
0.012145977,
-0.0042174472,
-0.0016159519,
0.023204457,
0.010310827,
0.0027544247,
-0.015374483,
0.02512117,
0.0038334252,
-0.019017596,
0.011744962,
0.013308239,
0.022089774,
0.0024094845,
-0.02486289,
-0.019262282,
-0.027785536,
-0.034337703,
-0.0018912244,
-0.026358197,
0.005121429,
0.005121429,
0.006620135,
-0.0009294697,
-0.017005727,
-0.008502863,
0.016203698,
0.02427836,
0.014504485,
-0.0058317003,
-0.0077688033,
0.0012234336,
0.007462945,
0.01760385,
-0.016380416,
-0.0030568847,
0.0031996188,
-0.012084805,
0.013450973,
-0.011269183,
0.008686379,
-0.037029255,
-0.0034120204,
0.002987217,
-0.019085564,
0.009284502,
-0.02369383,
-0.011330354,
-0.0029515335,
0.0075445073,
-0.0010730532,
0.026983507,
0.039856747,
0.03444645,
0.012322695,
0.004564087,
0.021736337,
-0.003704285,
-0.011860509,
0.016706666,
0.010059343,
0.0095223915,
0.024237579,
-0.034718327,
-0.029362407,
-0.001505503,
0.020159466,
0.004006745,
-0.020295404,
0.01591823,
-0.009366063,
0.0010917445,
0.026276635,
0.009257314,
0.0038878,
0.007945522,
-0.022565553,
-0.012275117,
0.0031350486,
0.036866132,
-0.016040573,
-0.014409329,
0.011479885,
-0.010732232,
-0.039340187,
-0.0311024,
-0.037355505,
-0.001345777,
0.000096377255,
0.004706821,
0.0019897788,
-0.02633101,
-0.028682722,
0.027975848,
0.008197005,
-0.04804016,
0.011486682,
-0.012682929,
-0.005423889,
-0.009182549,
-0.0039013939,
-0.010664263,
0.026181478,
0.018215567,
-0.0040611196,
-0.0013517241,
0.0024281759,
-0.001453677,
-0.00022557056,
-0.02347633,
-0.004723813,
-0.000085013766,
-0.033875518,
0.0041528773,
-0.001864037,
0.025093982,
-0.027826317,
0.029824592,
-0.021532431,
-0.0042004553,
-0.014055893,
-0.017359164,
-0.015061827,
0.019765249,
-0.02427836,
0.014721984,
0.03058584,
0.027812723,
0.02758163,
0.02350352,
0.0059608403,
0.009284502,
-0.00419026,
-0.018215567,
0.037328318,
-0.010528326,
-0.02064884,
0.008699972,
-0.0015343897,
-0.0017790764,
-0.007728022,
-0.023326801,
-0.011513869,
0.013505347,
0.005553029,
-0.0037008866,
0.000329435,
0.0143549545,
0.005451076,
-0.025624137,
0.011180824,
-0.0016185007,
-0.008346536,
0.01797088,
-0.013627691,
0.044641733,
0.02497164,
0.04782266,
-0.018569004,
0.011520666,
-0.0004468931,
-0.005321936,
-0.010732232,
0.010548716,
0.022456802,
0.016230885,
-0.018990409,
-0.0032030172,
0.0021783914,
-0.003138447,
0.03025959,
-0.007333805,
0.04265705,
0.001175006,
0.021138214,
0.001131676,
-0.64597297,
-0.008190208,
-0.007143493,
-0.0063856435,
0.006229316,
-0.018147599,
-0.0024043869,
-0.00924372,
-0.039856747,
0.026670853,
-0.0006121416,
0.0009838445,
0.008067865,
-0.02769038,
-0.03425614,
-0.03417458,
-0.00027612215,
0.0061307615,
-0.001520796,
0.018066036,
-0.0037348708,
0.006300683,
-0.009930203,
0.020132279,
-0.0018334512,
0.004309205,
0.017060101,
-0.018596191,
0.017780568,
0.0067730644,
-0.02145087,
0.022674304,
-0.006562362,
0.0038572142,
0.047034226,
-0.01969728,
-0.0072522424,
0.014219017,
0.011690588,
0.047741096,
-0.035234887,
-0.02816616,
0.0097195,
0.00031053124,
-0.006147754,
0.031727713,
0.0010263248,
0.008523254,
-0.0067900564,
-0.026752414,
0.016421197,
0.0023890939,
-0.00075572514,
0.021505244,
-0.0000036241033,
-0.014110267,
-0.00070432393,
-0.031401463,
-0.0017926701,
-0.01907197,
-0.0011520666,
-0.01347816,
0.0011478186,
0.0031163571,
-0.022198522,
0.011581838,
0.008523254,
0.0030619823,
-0.0059540435,
-0.033821143,
0.015388076,
0.04048206,
-0.012268321,
0.007938725,
0.0016465377,
0.02879147,
0.022823833,
-0.006779861,
-0.0014621731,
-0.008278567,
-0.0078095845,
-0.0072930236,
-0.022538366,
0.008020286,
0.021532431,
-0.021872275,
-0.012750897,
0.018936032,
0.0059268563,
0.00848927,
-0.0021019268,
0.0216004,
-0.016815415,
-0.04812172,
-0.005488459,
0.029199282,
0.014830734,
-0.0023279223,
0.009787469,
-0.022769459,
-0.01129637,
-0.0035615512,
0.047034226,
0.0015802684,
0.019235095,
0.0040713153,
-0.013947143,
0.0031503416,
0.015741512,
-0.019058377,
-0.011996446,
-0.00042671495,
-0.013185895,
-0.009420439,
-0.0037620582,
-0.025678512,
0.039149877,
-0.0032913762,
0.0034714928,
-0.026249448,
0.018718533,
0.007843569,
0.011350745,
-0.045647666,
0.0066167368,
0.01738635,
0.0059438483,
-0.017291196,
-0.0071502896,
-0.027037883,
0.018134005,
-0.019425407,
0.021913055,
-0.022511179,
0.020200249,
0.0046626413,
0.017739788,
0.0033032708,
0.01786213,
-0.014164642,
-0.0505414,
-0.006253105,
-0.01397433,
-0.010256452,
0.00094901066,
-0.030096466,
0.011112855,
-0.01056231,
0.011357542,
-0.0064264247,
-0.00084493385,
0.001840248,
0.0030398925,
-0.0012208847,
0.009257314,
-0.004207252,
0.01708729,
-0.005773927,
-0.001557329,
0.016312448,
0.00048809903,
0.022130555,
-0.0134577695,
0.0059948247,
-0.022660708,
-0.012390664,
-0.0024111837,
0.0037620582,
-0.0002697501,
-0.04048206,
0.010079733,
-0.018936032,
-0.01045356,
-0.0046558445,
-0.0032998724,
-0.0071095084,
-0.01466761,
-0.024985233,
0.0039591673,
-0.018405879,
0.005131624,
-0.009637938,
0.0031673335,
-0.013892768,
0.025093982,
0.01730479,
0.056386694,
0.007877553,
0.009549579,
0.0252707,
0.005862286,
0.0148987025,
-0.030748965,
0.002358508,
0.029308032,
-0.03428333,
0.04108018,
0.036594257,
0.0014298881,
0.008502863,
0.015999792,
-0.007836772,
0.020404154,
-0.008910675,
0.0074221636,
-0.036295198,
0.010310827,
-0.026385384,
0.0034782896,
0.021804305,
0.021790711,
-0.005257366,
-0.027459288,
-0.025161952,
0.0058588875,
0.017998068,
0.010059343,
0.0153472945,
-0.0042004553,
0.0031418453,
-0.017005727,
-0.001920111,
0.031075213,
0.005121429,
-0.020784777,
0.028410846,
0.004180065,
0.006236113,
0.010079733,
0.014463704,
0.00080925034,
0.0023466137,
-0.011513869,
0.0059608403,
0.033250205,
0.003034795,
-0.0047577973,
-0.009182549,
0.028573971,
0.008462083,
0.014300579,
0.0020084702,
-0.0042480333,
-0.027350537,
0.016353229,
0.016829008,
0.027459288,
-0.0036736992,
-0.022361647,
-0.008346536,
-0.0115070725,
-0.01730479,
-0.00083388895,
0.009406845,
0.021586806,
-0.019439,
0.010528326,
-0.0059132623,
0.04583798,
0.016815415,
0.0145452665,
-0.011670197,
-0.0011928477,
-0.010793403,
0.0051452178,
-0.015265733,
-0.037573006,
-0.034636766,
-0.016584322,
-0.009556375,
-0.011357542,
0.0032641888,
-0.003687293,
-0.016162917,
0.020716809,
0.000230031,
-0.0050534606,
0.011840118,
0.021668369,
0.02054009,
-0.009420439,
-0.026861165,
0.00083558814,
0.010222468,
0.0072930236,
-0.018161193,
-0.00054289866,
0.0041460805,
0.012893631,
0.025148356,
0.026833978,
0.01529292,
-0.02317727,
-0.017522288,
0.008088255,
0.014436516,
0.037002068,
-0.01907197,
-0.01201004,
-0.0040815105,
0.0012438241,
0.002771417,
-0.013851987,
-0.029715843,
0.014314173,
0.0009940398,
-0.00045071632,
-0.02416961,
-0.011649807,
0.022660708,
0.011588635,
-0.027037883,
-0.011072074,
0.0065929475,
-0.012098399,
0.0148987025,
0.0010254752,
0.015469638,
0.034745514,
-0.0068206424,
-0.0065215807,
-0.005233577,
-0.02783991,
-0.0054204906,
0.048312034,
0.00044137065,
-0.0062802923,
0.012084805,
0.012621757,
-0.01708729,
0.005566623,
-0.008795128,
0.04360861,
0.014110267,
-0.00673908,
0.005369514,
0.00017416937,
0.003201318,
-0.0010246256,
0.009705907,
-0.008353333,
-0.024726951,
-0.00072853774,
0.011398323,
-0.007313414,
-0.012438241,
0.0049583046,
0.039747998,
0.026031949,
-0.0046388526,
0.001358521,
0.011656604,
0.0017518889,
-0.00967872,
-0.025447419,
0.014735578,
-0.01287324,
0.033902705,
-0.0024927459,
0.00027675938,
0.007789194,
-0.00825138,
0.0015683739,
-0.004292213,
0.015537607,
0.0046388526,
0.015034639,
0.018283535,
0.0065283775,
-0.015945418,
0.015197764,
-0.018677752,
-0.021410087,
-0.0074425545,
0.03202677,
-0.0044893217,
-0.017100884,
-0.002453664,
-0.002762921,
0.019846812,
0.007360992,
-0.019724468,
-0.017875724,
0.00412569,
-0.031890836,
-0.044179548,
0.027731162,
-0.0017051606,
0.0010705044,
-0.006667713,
-0.00087424525,
0.0055292402,
-0.04309205,
-0.03596895,
-0.004978695,
-0.023924924,
-0.0058181062,
0.018596191,
0.026208667,
0.005073851,
0.00044179548,
-0.016407603,
0.0076668505,
-0.0045776805,
-0.024414297,
0.0045131105,
0.013960737,
-0.025923198,
0.019873999,
0.013294645,
0.008931065,
0.010650669,
0.011575041,
-0.0054442794,
0.0042820177,
0.0051724054,
0.005253968,
-0.012941209,
0.008543645,
0.0058181062,
0.015143389,
0.02941678,
-0.00097534846,
-0.017196039,
0.017590256,
0.0039863545,
-0.023829767,
0.0011010902,
-0.0106098885,
-0.010113718,
-0.017658224,
0.013512145,
-0.014857922,
-0.02680679,
0.022388835,
-0.007863959,
0.008244583,
-0.01466761,
0.010650669,
-0.0155512,
0.016421197,
0.0029838185,
0.022946177,
0.015415263,
0.00030989404,
-0.0020849349,
0.0092980955,
0.013593706,
-0.009869031,
0.003321962,
-0.00520639,
-0.004462134,
-0.03890519,
-0.011656604,
-0.0050228746,
0.02794866,
-0.012954802,
-0.015687138,
-0.016774634,
0.005886075,
-0.011140043,
0.024468672,
-0.030069279,
-0.0038368236,
0.0028716705,
0.013913158,
-0.0005892022,
-0.00096175476,
0.033386145,
-0.02974303,
-0.012343085,
0.0064909947,
0.014640422,
0.021056652,
-0.011676994,
-0.0113779325,
-0.00045114112,
-0.015048233,
-0.019017596,
-0.048012972,
0.0036601054,
0.0033712392,
0.013947143,
0.026494134,
0.024264766,
-0.0098758275,
0.012791678,
0.0011699083,
-0.014137455,
0.020961495,
-0.008088255,
-0.0013100934,
-0.0016813716,
-0.0029107523,
0.016366823,
0.0017722795,
-0.019819625,
-0.019221501,
-0.009005831,
0.024998827,
0.0065113856,
-0.0061511523,
-0.00801349,
-0.038116753,
0.002079837,
0.019561345,
0.0024842499,
0.009182549,
-0.032842394,
0.007374586,
0.03906831,
-0.002771417,
0.010766216,
0.010936137,
0.019860405,
-0.002302434,
0.0022837427,
-0.01650276,
-0.016829008,
-0.0030195022,
-0.0054001,
-0.019044783,
-0.014395735,
0.025732886,
-0.013376207,
0.015415263,
0.019792438,
0.011765353,
-0.0043160017,
-0.0068614236,
-0.0026473743,
-0.0014587747,
0.011840118,
0.0031027636,
-0.017984474,
-0.029226469,
-0.0148035465,
-0.012587773,
-0.004322799,
0.0084348945,
0.0031979196,
-0.00021813651,
-0.03167334,
0.0035955354,
0.0429833,
-0.021056652,
0.028818658,
-0.008577629,
0.033223018,
0.015170577,
0.0023075317,
-0.025610544,
-0.027051477,
-0.00850966,
0.024183204,
0.00049447105,
0.0062836907,
-0.013104334,
-0.03825269,
0.02060806,
-0.005498654,
0.0014961574,
-0.026004761,
0.03496301,
-0.008944659,
-0.006892009,
-0.01114684,
-0.02607273,
-0.01991478,
0.0019880796,
-0.023204457,
-0.017522288,
0.00072938734,
-0.0010314225,
0.00051443686,
0.022048993,
-0.0012395761,
0.02347633,
-0.014395735,
0.0082105985,
-0.0038844016,
-0.015129795,
-0.016679479,
0.003041592,
0.018093223,
0.019778844,
-0.002637179,
0.018569004,
-0.0022735475,
0.016611509,
-0.011846915,
0.0115070725,
-0.0057297475,
0.034827076,
-0.019602126,
-0.00062276167,
-0.00563799,
0.0018368496,
-0.018038848,
-0.01492589,
-0.018337911,
-0.0036669024,
0.006117168,
-0.01067106,
0.040590808,
0.008767941,
0.0013398298,
0.009345673,
-0.018106816,
-0.0011257288,
-0.021627586,
-0.023870548,
-0.018827284,
-0.026630072,
0.006936189,
0.013049958,
0.015184171,
0.020363372,
0.011439105,
-0.01393355,
0.0019472985,
0.018365098,
-0.024033673,
0.02291899,
0.025297888,
0.014749172,
-0.019153534,
-0.002796905,
-0.012812069,
-0.016924165,
0.023598675,
-0.0054442794,
-0.019724468,
-0.021070246,
0.01885447,
0.030096466,
-0.008482473,
-0.021138214,
0.014055893,
0.005828302,
-0.004842758,
-0.00042395372,
-0.023231644,
0.05402139,
0.0016949653,
-0.021219777,
0.031455837,
-0.012193555,
0.023571488,
-0.0045504933,
0.029253656,
0.003242099,
-0.030042091,
0.006028809,
0.0054850606,
0.02350352,
-0.0118809,
0.0049209218,
0.0007612476,
-0.016108543,
-0.008598019,
0.03395708,
-0.011792541,
0.0017187543,
-0.023938518,
-0.0130431615,
-0.020988682,
0.0074357577,
0.0023856955,
-0.0020883332,
0.01032442,
-0.0278671,
-0.05725669,
-0.0009209736,
-0.020730402,
0.026004761,
0.016829008,
-0.009637938,
-0.040536433,
0.011629416,
-0.060410433,
-0.012750897,
0.01032442,
-0.00559381,
0.02060806,
0.0072250552,
0.0022242703,
0.021763524,
0.007456148,
0.024455078,
-0.026861165,
-0.021940242,
0.021641182,
-0.0015072023,
0.020512903,
0.026466947,
-0.015483232,
0.0021155206,
-0.009631141,
-0.0039591673,
-0.017413538,
0.004971898,
-0.020771183,
0.008598019,
-0.013818003,
0.005498654,
-0.02263352,
-0.006643924,
0.021722743,
-0.022823833,
-0.013484957,
0.011330354,
-0.019452594,
-0.009067003,
-0.0056142006,
0.00024128829,
0.0037178788,
0.0042344397,
-0.022755865,
-0.028655533,
-0.002270149,
-0.017889317,
0.028818658,
0.0005756085,
0.0043771737,
0.03605051,
-0.004883539,
-0.010732232,
-0.01646198,
0.014055893,
-0.036023322,
0.0044247517,
0.009406845,
0.0043839705,
0.014246205,
0.0086388,
0.018161193,
-0.016285261,
0.0157687,
-0.016081356,
-0.024985233,
-0.03246177,
0.021654775,
0.007259039,
-0.016067762,
-0.008733956,
0.014681203,
-0.012213945,
-0.008142631,
0.01030403,
-0.010181686,
-0.015537607,
0.0149938585,
-0.00836013,
0.002875069,
-0.011704181,
0.010664263,
0.012533397,
-0.008278567,
0.01855541,
0.16964945,
0.0019065173,
0.0029328421,
0.020730402,
0.026344603,
-0.00449272,
-0.0043194,
0.007428961,
0.002533527,
0.02142368,
0.02438711,
0.019724468,
0.021627586,
0.009481611,
0.0046796333,
-0.01764463,
0.0010059343,
-0.0151569825,
-0.016040573,
-0.0074765384,
0.026929133,
-0.005253968,
-0.0022616528,
-0.01911275,
0.043880485,
0.013213083,
-0.012730506,
-0.008665988,
0.0027748153,
-0.0010042351,
-0.013247067,
0.010908949,
0.021478057,
-0.0010637075,
-0.014219017,
-0.009882624,
0.0024927459,
-0.015320107,
0.010446764,
0.008292161,
-0.006657518,
0.0033389542,
0.0077688033,
-0.014137455,
0.009855437,
0.021872275,
-0.0034935826,
-0.0039115893,
-0.02174993,
0.0018351504,
-0.019275876,
-0.024876483,
-0.02911772,
0.011085668,
-0.0070551336,
-0.0011163831,
0.038524564,
0.012893631,
-0.007163883,
0.02347633,
-0.0030755762,
0.009964187,
-0.018433066,
0.017005727,
-0.0010883461,
0.008285364,
-0.01213918,
0.02306852,
-0.0060899807,
0.010072936,
-0.010575904,
-0.02665726,
-0.005668576,
0.0028733697,
-0.0027051477,
-0.011452698,
0.0016431393,
0.0038062378,
0.0018776307,
0.02559695,
0.005366116,
0.010637076,
0.012111993,
0.0064094327,
-0.0017484905,
-0.03047709,
0.04192299,
0.013987924,
-0.03238021,
0.0024791523,
0.0216004,
-0.003298173,
0.0007230153,
-0.016244479,
0.0032930754,
-0.01114684,
-0.004978695,
0.009855437,
0.013049958,
0.017889317,
-0.008815519,
0.035914574,
0.022497585,
-0.00704154,
0.013885971,
0.0070551336,
-0.023313208,
0.011119652,
0.011140043,
-0.014205423,
-0.0012684627,
-0.025338668,
0.01782135,
0.006650721,
0.020268217,
0.0154424505,
0.04118893,
-0.018134005,
0.007748413,
0.018460253,
0.00527096,
-0.04214049,
0.00836013,
0.0252707,
-0.01129637,
-0.039612062,
-0.029987717,
0.008258177,
-0.019221501,
0.0030789746,
0.013831597,
-0.027595224,
-0.025297888,
-0.011439105,
0.007089118,
-0.025828043,
0.004652446,
-0.041950177,
-0.011106058,
0.018337911,
-0.0143549545,
0.0024740547,
0.013919955,
0.018541817,
0.016611509,
-0.021043058,
0.020771183,
0.012696522,
-0.0113779325,
-0.010208874,
-0.002667765,
-0.0002037994,
0.017440725,
0.016706666,
0.020404154,
-0.011269183,
-0.02108384,
-0.05021515,
-0.0030568847,
-0.000087031585,
-0.022783052,
0.0118265245,
0.00022493336,
-0.015578388,
-0.0027340343,
0.012288711,
-0.17269444,
-0.009665125,
0.027146632,
-0.03371239,
0.024332736,
-0.0008678732,
0.015279327,
-0.012560585,
-0.02783991,
0.004723813,
0.0028393855,
0.026290229,
-0.02522992,
0.0067730644,
0.00032816056,
0.0108002,
-0.017060101,
0.013022771,
0.030422715,
0.015048233,
0.04833922,
-0.0386605,
0.02974303,
-0.021396494,
0.0041290885,
0.039856747,
-0.0004067492,
0.0068614236,
0.009760281,
-0.050677337,
-0.033386145,
-0.004468931,
0.019493375,
-0.016529948,
0.014953077,
0.010637076,
0.004530103,
-0.0037722536,
-0.014123861,
0.03292396,
0.009671922,
0.007598882,
-0.016217291,
-0.00041609487,
0.00050594076,
0.020689622,
-0.018215567,
-0.008835909,
0.0023466137,
-0.031075213,
0.021831492,
-0.0010934438,
0.021518838,
-0.0035649496,
0.010705044,
-0.004302408,
-0.0011027894,
-0.000736609,
0.019996343,
-0.018242754,
-0.0012132383,
0.0014409329,
0.012037227,
-0.0035547542,
-0.0045708837,
-0.01786213,
-0.026127104,
0.035833012,
-0.009325283,
0.0010535122,
-0.0030245997,
0.025297888,
-0.0022752467,
-0.015605575,
0.021206181,
0.028356472,
0.00740857,
0.020213842,
0.015374483,
-0.02412883,
0.0046660397,
0.037382692,
-0.033603642,
0.0020254622,
0.01069145,
0.0097127035,
0.030966464,
0.008475676,
0.02827491,
0.004700024,
-0.02002353,
-0.01756307,
0.009767078,
-0.020105092,
0.0011588635,
0.022266492,
-0.0015955613,
-0.01529292,
0.01708729,
0.019153534,
0.012852849,
-0.03216271,
-0.02313649,
0.023816174,
0.018582597,
-0.0043058065,
-0.0018011661,
-0.0022344654,
0.017100884,
-0.00092267286,
-0.037083633,
-0.028954595,
0.01492589,
-0.005386506,
-0.019126344,
0.037763316,
0.012601366,
0.00045708838,
-0.005903067,
-0.004349986,
0.06405354,
0.006667713,
-0.0136820655,
0.0006482499,
0.0057467395,
-0.03838863,
-0.13593706,
-0.0052029914,
0.004971898,
0.012451835,
-0.007259039,
0.03580582,
-0.015959011,
0.01153426,
-0.017576663,
0.022103367,
-0.039666437,
-0.0069157984,
0.003058584,
-0.022538366,
0.02490367,
0.013260661,
0.03982956,
-0.031048026,
0.0027187413,
0.040101435,
0.0213829,
-0.037681755,
-0.02911772,
-0.013124724,
-0.0030076075,
0.008577629,
-0.023381175,
-0.0054272874,
0.0058113094,
0.013552926,
0.0035819416,
-0.010263248,
0.014477298,
-0.026643666,
-0.025637731,
-0.0018181583,
-0.0067356816,
-0.02911772,
0.017399944,
-0.021926649,
-0.0034035244,
-0.0004197057,
0.026099917,
0.0053321314,
0.03920425,
-0.041895803,
-0.021505244,
0.020132279,
0.025325075,
-0.018541817,
-0.00485975,
-0.016597915,
-0.019044783,
-0.01738635,
0.015224951,
0.0011197816,
0.006276894,
0.021070246,
-0.017807756,
0.009338876,
-0.0040577212,
0.0027816123,
-0.020689622,
-0.00924372,
0.0030381933,
-0.03205396,
-0.0313199,
-0.013049958,
0.0134917535,
-0.016244479,
-0.013899565,
0.02259274,
-0.012771287,
-0.021464463,
-0.018840877,
0.014626828,
-0.022783052,
0.007000759,
0.009230127,
-0.026684446,
-0.013784018,
-0.01782135,
0.015184171,
-0.0119216805,
0.024115236,
0.024264766,
0.005760333,
-0.0020492512,
-0.0037450662,
-0.015510419,
-0.0078095845,
-0.0020815362,
0.009427235,
-0.0012166367,
-0.0015360889,
0.023245238,
-0.008264974,
-0.023462737,
0.0010271744,
0.011853713,
-0.027268976,
-0.015646357,
-0.032706458,
0.014531672,
0.010093328,
-0.023394769,
-0.0037552614,
-0.021274151,
0.0016813716,
0.0059166607,
-0.0035309652,
-0.0059438483,
-0.0071570864,
0.001028024,
-0.048991717,
0.0026796595,
-0.007653257,
-0.020064311,
0.009896219,
-0.011500276,
0.043363925,
0.028111786,
-0.0014196928,
0.0042242445,
-0.010759419,
0.03825269,
-0.026453353,
-0.0057943175,
0.008258177,
0.027975848,
0.0050296714,
0.0050874446,
0.008910675,
-0.020811966,
0.00031159323,
0.010018562,
-0.018759316,
-0.009359267,
0.004101901,
0.021790711,
0.012213945,
0.027500069,
-0.012349882,
-0.01580948,
0.023150083,
-0.032217085,
-0.0152521385,
-0.004931117,
0.0049956874,
0.0040713153,
-0.0148035465,
0.012071212,
0.029280843,
0.0064807995,
-0.0029583303,
-0.026915539,
-0.0060661915,
-0.018636972,
0.011649807,
0.0029770217,
-0.0051893974,
-0.005114632,
0.022198522,
0.032325834,
0.006222519,
-0.0050228746,
-0.011208011,
-0.0196565,
-0.017916506,
0.0017187543,
0.00031371726,
-0.018038848,
-0.04771391,
0.00021537529,
0.018419473,
-0.014164642,
0.0017009125,
-0.012186758,
-0.024359923,
0.012723709,
-0.009529188,
0.026820384,
0.01201004,
0.006796853,
-0.02321805,
0.03626801,
0.01928947,
0.0015072023,
-0.034663953,
0.008468879,
-0.026086323,
0.00045538918,
-0.023299614,
0.017372757,
-0.00074383063,
-0.011547854,
-0.0038742064,
0.011085668,
0.0031877242,
-0.014830734,
0.023190863,
0.031782087,
0.010032156,
-0.0040509244,
-0.007945522,
-0.034093015,
-0.0108341845,
0.0047883834,
-0.016638696,
-0.021817898,
0.0032998724,
0.00075997313,
-0.020920714,
0.010405983,
0.004482525,
0.0013721148,
-0.008149427,
0.010643872,
-0.0056991614,
-0.0073473984,
-0.025474606,
0.010113718,
0.0148035465,
0.018949628,
-0.010460357,
-0.0079863025,
0.007680444,
0.0084009105,
0.020145873,
-0.013253864,
0.03216271,
-0.0012013438,
0.015959011,
0.022986958,
-0.025963979,
-0.017141664,
-0.011812931,
-0.02017306,
0.014246205,
0.009821453,
0.0143549545,
0.064597294,
0.024373516,
-0.00080627674,
0.021885868,
-0.032815207,
0.015428857,
0.022483991,
0.010575904,
-0.015578388,
-0.045729227,
0.013083942,
-0.0048801405,
0.01995556,
-0.03871488,
-0.021151807,
0.033739578,
-0.018161193,
0.018636972,
-0.025719292,
0.00032497454,
0.033984266,
-0.0020373568,
0.035506763,
0.013879174,
-0.027268976,
-0.011955665,
0.008611613,
-0.025148356,
-0.0030857713,
-0.012349882,
-0.0011936973,
0.010317624,
-0.028873032,
0.0012837556,
-0.00825138,
0.0009711004,
-0.039612062,
-0.013675269,
0.0064332215,
0.023272425,
-0.019873999,
0.00092267286,
-0.017535882,
-0.0017569866,
-0.007286227,
0.029797405,
-0.0025539177,
-0.010514732,
-0.040454872
] |
Mounting evidence indicates that inflammatory cytokines contribute to the development of depression in both medically ill and medically healthy individuals. Cytokines are important for development and normal brain function, and have the ability to influence neurocircuitry and neurotransmitter systems to produce behavioral alterations. Acutely, inflammatory cytokine administration or activation of the innate immune system produces adaptive behavioral responses that promote conservation of energy to combat infection or recovery from injury. However, chronic exposure to elevated inflammatory cytokines and persistent alterations in neurotransmitter systems can lead to neuropsychiatric disorders and depression. Mechanisms of cytokine behavioral effects involve activation of inflammatory signaling pathways in the brain | [
-0.018403107,
-0.010348562,
0.021563752,
-0.03305932,
-0.029694766,
0.0058720442,
-0.024966544,
-0.0079271,
0.0031144456,
-0.016351238,
-0.0052157007,
0.005263493,
0.01944816,
0.029898679,
-0.030051613,
0.016631618,
0.057452362,
0.00050261256,
-0.017319823,
-0.006601669,
-0.028828137,
0.023182308,
0.0058306246,
-0.014465047,
-0.020251065,
0.02574396,
0.010941183,
-0.061887458,
-0.006678136,
-0.022659782,
-0.005983559,
0.0013102974,
-0.01779137,
-0.010546102,
0.007863378,
-0.0124769,
0.021143183,
-0.017689414,
-0.0036767982,
0.01197349,
0.023118585,
-0.011317147,
-0.0052316315,
-0.017714903,
0.0058497414,
0.012438666,
0.015790477,
-0.02012362,
-0.013114126,
0.014146433,
0.040170774,
-0.0019021218,
-0.009959854,
0.0028245074,
-0.0024294269,
-0.024163637,
-0.0044414704,
-0.0064933402,
0.00739183,
-0.03935512,
-0.01672083,
-0.016070858,
-0.006225705,
0.017549224,
0.0059325807,
0.0023800419,
-0.009704963,
0.018262917,
0.004505193,
0.0034219075,
0.037672844,
0.044274513,
-0.012527877,
-0.007774166,
0.011399986,
0.0019626583,
0.0076722098,
-0.00809278,
0.0033613709,
-0.0019228316,
0.01408271,
-0.038131647,
-0.007646721,
0.012642578,
0.0048779706,
-0.0027289235,
-0.002217549,
0.010909322,
-0.00073958124,
-0.009889759,
-0.022723505,
0.017268844,
0.0051424196,
0.0333397,
0.013725864,
0.022659782,
-0.0055980366,
0.039813925,
0.00026245776,
-0.03866692,
-0.010278467,
-0.0026763522,
-0.002505894,
-0.0190021,
-0.028700693,
-0.003648123,
-0.0048269923,
0.005285796,
0.03117313,
-0.005626712,
-0.0005344739,
0.010794621,
-0.036296435,
-0.060969852,
0.022978395,
0.014732682,
-0.01886191,
-0.0011095711,
-0.012757279,
-0.018135473,
0.0040941816,
0.0023195052,
0.011349008,
-0.011814184,
0.009233415,
0.012049957,
-0.00472185,
-0.0032482632,
-0.018135473,
-0.003769196,
-0.029694766,
0.024711652,
0.01683553,
-0.0009590262,
-0.017154144,
0.025858661,
-0.013203338,
-0.008844707,
-0.017409034,
-0.0050563943,
0.0014337602,
0.019320715,
-0.02257057,
-0.018849166,
-0.0053017265,
0.014273879,
0.023093097,
0.012330337,
0.033263236,
0.00021864842,
-0.01301217,
-0.022328425,
0.001669534,
-0.009603007,
-0.0010458484,
0.024469506,
-0.018658,
0.03234563,
-0.017179633,
-0.026610589,
0.0008411393,
-0.038437515,
-0.00843051,
0.011807811,
0.014745426,
0.007538392,
0.01807175,
0.0023577388,
0.012075447,
-0.013725864,
0.014273879,
0.02515771,
-0.013917032,
0.037341487,
-0.01672083,
-0.0021745362,
0.015420887,
0.017969795,
0.00025847508,
-0.0156248,
-0.011559293,
0.017969795,
0.016351238,
-0.0057414128,
-0.010463263,
-0.010495124,
0.03392595,
-0.02928694,
-0.0019005287,
-0.01681004,
-0.005674504,
0.0065220157,
-0.025106734,
-0.04409609,
-0.64028543,
-0.01860702,
0.017409034,
-0.011049512,
-0.0124769,
0.034053396,
0.0030698397,
0.00048469056,
-0.01565029,
0.022647038,
0.009590263,
0.027528195,
-0.00023398169,
-0.029720254,
0.0036576814,
-0.029643787,
-0.022799972,
-0.027273305,
-0.0015062446,
-0.001476773,
0.0098451525,
0.0050882553,
-0.007965334,
0.011336263,
-0.0062926137,
-0.0028037976,
0.021652965,
-0.011036767,
-0.010507869,
0.05255846,
-0.019320715,
0.014465047,
0.010845599,
0.0009566366,
0.05418976,
-0.0051838392,
-0.00496081,
0.03119862,
0.0031064802,
0.027451728,
-0.023105841,
-0.027477216,
-0.005011788,
0.016351238,
-0.022048045,
0.026712544,
0.016032625,
-0.004294908,
0.008621678,
-0.015369909,
0.0019276108,
0.011801439,
-0.0054737777,
0.008984897,
0.012942075,
-0.003025234,
0.010533358,
-0.024749886,
0.020709869,
0.013177848,
-0.0032307394,
0.017625691,
-0.0121391695,
-0.015191485,
-0.004196138,
0.019116802,
-0.03122411,
-0.025234178,
0.007289874,
0.0077677937,
0.018237429,
0.026483143,
0.0006806378,
-0.019180525,
0.019206014,
0.029159496,
0.0019371692,
0.007009494,
-0.026636077,
0.009934365,
-0.019116802,
-0.006843815,
-0.026610589,
-0.0059039057,
0.016784552,
0.0012784362,
0.011897023,
0.007933472,
0.017217865,
-0.00040981645,
0.005359077,
0.00840502,
-0.023182308,
-0.02816542,
-0.015917923,
0.042847127,
0.0021363026,
-0.0016520103,
0.019218758,
0.018250173,
-0.0050500217,
0.005451475,
0.011724972,
0.018645255,
0.0088638235,
-0.013088637,
-0.032141715,
0.0048843427,
0.06724016,
-0.00032219777,
0.0034187215,
0.0042311857,
-0.021933343,
-0.02147454,
0.023462689,
-0.020161854,
0.021155927,
0.0048588538,
0.017855093,
-0.016491428,
0.01034219,
-0.003816988,
0.00045959977,
-0.010750015,
0.0028452172,
0.015866945,
-0.008201108,
-0.017243356,
-0.014528769,
-0.011062256,
0.0024835912,
0.008513349,
0.02287644,
-0.005413241,
0.0050627664,
0.014324857,
0.044835273,
-0.011591154,
-0.013980755,
-0.028649714,
-0.023845024,
-0.0098451525,
0.02161473,
0.015803223,
-0.009367233,
-0.00015452749,
-0.012483272,
-0.013177848,
-0.012196519,
-0.0049703685,
0.020722613,
0.0010458484,
-0.0053527043,
0.016606128,
0.020289298,
-0.008462371,
0.014796404,
-0.00533996,
0.014541514,
-0.022532336,
0.00005282012,
0.02315682,
-0.0053112847,
0.011540176,
-0.02257057,
0.00003442518,
0.0065379464,
0.029083028,
0.0024915566,
-0.031580955,
-0.024992032,
-0.015051295,
-0.021296117,
0.016465938,
-0.00050022296,
-0.00229083,
-0.012317592,
-0.030739818,
0.0055375,
0.003931689,
-0.0020885107,
-0.011603898,
-0.012763651,
-0.010800993,
0.0060695847,
0.009634868,
0.012578855,
0.013139615,
0.015115018,
0.03701013,
-0.014872871,
0.05031542,
-0.016007135,
0.018377619,
-0.0024182755,
-0.02121965,
0.0045211236,
0.0042598606,
0.00657618,
0.013394506,
-0.00992162,
-0.045548968,
-0.0018399921,
-0.011788694,
0.0133817615,
-0.028522268,
-0.00078856805,
-0.015204229,
0.00028177368,
-0.0071815453,
0.006321289,
0.004887529,
-0.0021665709,
0.018568786,
0.00027699448,
0.0020550562,
-0.0048524817,
0.005190212,
0.009348116,
-0.02315682,
0.0083412975,
-0.011826928,
0.0024724398,
-0.003171796,
-0.0065634353,
0.036806215,
0.010641687,
0.0037054734,
0.002934429,
-0.0041706488,
-0.00043092459,
0.0028069837,
-0.0034537688,
-0.0056713177,
0.011686739,
0.009144204,
-0.016504172,
-0.0022287006,
0.04458038,
0.021882366,
0.019779518,
0.0236666,
0.004122857,
-0.007105078,
-0.0030363854,
0.022099024,
0.021589242,
0.029643787,
0.01264895,
0.013802331,
-0.0023736695,
0.014159177,
-0.005645829,
-0.034282796,
-0.016911997,
0.016478684,
-0.0033486264,
-0.009685846,
0.046874397,
0.025986105,
0.019855985,
-0.0118333,
-0.0012322372,
-0.0016153697,
0.012903841,
0.0060982597,
0.0069967494,
0.0013294143,
-0.008927546,
-0.0118715335,
-0.04679793,
-0.00089530356,
0.009532912,
-0.034078885,
0.009462817,
0.0012298475,
0.03362008,
0.009137832,
0.021958834,
0.024571463,
0.010673548,
-0.018951124,
0.024316572,
0.022659782,
0.014707193,
-0.0028659273,
-0.028394822,
0.0067099975,
-0.0007825941,
0.00972408,
-0.004024087,
0.02481361,
0.0038552217,
-0.008895685,
0.0036226339,
0.0134454835,
0.026011596,
0.0021283373,
0.011629388,
-0.020365765,
0.010049066,
-0.0032514494,
-0.03662779,
0.010756387,
-0.0074236915,
0.011062256,
-0.016007135,
-0.022251958,
-0.008417765,
-0.0125979725,
0.018900145,
-0.0076658376,
-0.012706301,
-0.006958516,
-0.0013118905,
0.006314917,
0.005222073,
0.0026890968,
0.00795259,
0.0034378383,
-0.0016488242,
-0.033033833,
-0.0068820487,
-0.021997066,
0.036398392,
0.023080353,
-0.009481934,
0.0154081425,
0.009156948,
0.0016289108,
-0.0044000507,
-0.030943729,
0.018645255,
-0.015013061,
-0.016007135,
-0.02248136,
0.018097239,
0.008640794,
0.010813737,
0.007315363,
0.00229083,
-0.010418657,
0.009947109,
-0.017192377,
0.0048046894,
0.02655961,
0.009411839,
0.035225894,
0.03336519,
0.0031144456,
0.009144204,
0.050850693,
0.0063595227,
-0.026763523,
-0.003025234,
0.027018413,
-0.012132796,
0.030153569,
-0.010303956,
-0.004769642,
-0.01253425,
0.024584208,
0.010151022,
0.0153444195,
0.011954374,
-0.0019196455,
0.019855985,
-0.005703179,
-0.008685401,
-0.018199196,
0.025004776,
-0.0022494104,
-0.023347987,
-0.0012808257,
0.010157394,
-0.021257883,
-0.005840183,
-0.03341617,
0.033008344,
0.008972152,
0.0041642766,
-0.008481488,
-0.005461033,
0.007653093,
-0.017855093,
-0.022226468,
0.016453194,
-0.013458229,
-0.005202956,
-0.02119416,
-0.00882559,
0.017523736,
0.0011979862,
-0.0095838895,
0.015764989,
-0.027324282,
-0.014617981,
0.0027575986,
0.009819664,
0.017995283,
0.0019706236,
-0.00916332,
0.0020550562,
0.025221433,
-0.011234307,
-0.01371312,
0.0010283246,
-0.0034059768,
0.01697572,
-0.0063786395,
0.0066590193,
-0.01835213,
-0.011425476,
-0.00031960904,
0.00563627,
-0.010017204,
-0.0081437575,
0.0026094434,
-0.010711782,
0.02189511,
0.021130439,
0.008895685,
0.0035174915,
-0.018046262,
0.011763206,
-0.01919327,
-0.01914229,
-0.03277894,
-0.010425029,
-0.023959724,
0.0045338683,
0.01127254,
0.015025807,
-0.008194735,
0.021793153,
-0.024533229,
-0.015191485,
0.006703625,
0.0106990365,
0.004024087,
0.01706493,
0.012222009,
0.014834638,
-0.0012099342,
-0.009998088,
-0.021793153,
0.017230611,
0.008385904,
-0.012967564,
-0.012744535,
0.008086408,
-0.015395397,
-0.0317084,
0.00677372,
-0.024405783,
0.02877716,
-0.014541514,
-0.041139357,
-0.030230036,
0.005961256,
-0.0037723822,
0.033823993,
0.0076658376,
-0.030204548,
-0.010781876,
-0.017332567,
-0.028598735,
-0.026075318,
0.043713752,
-0.039482567,
-0.024800865,
0.013177848,
0.0048684124,
0.015803223,
-0.028267378,
-0.013853309,
-0.020480467,
0.012833746,
0.0064041284,
-0.04101191,
0.01658064,
-0.0019244247,
0.0503664,
-0.0007403778,
0.027324282,
0.013254316,
0.024826353,
-0.008710889,
0.010890204,
-0.016070858,
0.0021665709,
0.019129546,
-0.03012808,
0.016351238,
-0.0033167652,
-0.004696361,
0.011769578,
-0.02467342,
-0.012566111,
0.006958516,
-0.013063148,
-0.033569105,
-0.031147642,
-0.033747528,
-0.017842349,
0.023641111,
-0.0023800419,
0.022264702,
-0.03150449,
0.007837889,
0.031453513,
0.007895239,
0.013088637,
-0.0095201675,
0.016886508,
-0.024979288,
0.009023131,
-0.018428598,
-0.002811763,
-0.018377619,
-0.0075256475,
0.018135473,
0.003434652,
0.019295225,
-0.0066462746,
0.02161473,
-0.008634422,
-0.0030156756,
-0.019409927,
-0.00081166753,
-0.027579173,
-0.008685401,
-0.033467147,
-0.013394506,
-0.0031335624,
-0.009207926,
-0.0076212315,
-0.03206525,
0.018403107,
-0.0020885107,
-0.016465938,
0.024138149,
-0.008500605,
-0.016644362,
0.017192377,
-0.0036417507,
0.019129546,
-0.024609696,
0.020454979,
0.0019387623,
0.00014735867,
-0.008838335,
-0.005432358,
-0.00042176445,
0.0070987055,
0.0377748,
0.02683999,
0.0008610526,
-0.004310839,
0.012897469,
-0.015000317,
-0.013203338,
-0.0076722098,
0.018581532,
0.0021187789,
0.009711335,
-0.023093097,
-0.008334925,
-0.014286623,
0.014133689,
-0.019269736,
-0.008774612,
0.011967118,
-0.006321289,
0.0019276108,
0.014210156,
-0.012088191,
0.032116227,
0.012744535,
-0.0049002734,
-0.021232395,
0.006601669,
-0.02709488,
0.0031606446,
0.031657424,
0.021015737,
0.0011995793,
0.015930668,
0.0031176317,
0.0047951313,
0.0030427575,
0.006034537,
-0.0326515,
0.041521695,
-0.023845024,
-0.004696361,
0.0060249786,
-0.031835847,
0.014439558,
-0.023182308,
-0.0028977885,
-0.01700121,
-0.0172561,
-0.0066590193,
0.01006181,
0.0037564517,
-0.0077614216,
0.015331675,
-0.023386221,
-0.00020909002,
-0.015242463,
-0.017345311,
-0.00719429,
-0.026406676,
0.014694449,
-0.010195628,
0.015255208,
0.024979288,
0.011521059,
-0.010405912,
0.0017555596,
0.005722296,
-0.0005356687,
0.015943414,
0.020709869,
0.009252532,
-0.006391384,
0.01025935,
-0.026381187,
-0.0009391129,
-0.006582552,
-0.031147642,
-0.022850951,
0.013725864,
0.00090486195,
0.031122154,
0.00028316764,
0.019295225,
0.033849485,
0.001608201,
-0.014006243,
-0.0034856303,
-0.019652072,
0.028700693,
-0.038743384,
-0.015917923,
0.03316128,
0.0070222383,
-0.016453194,
-0.00882559,
0.022532336,
0.022328425,
0.0033741156,
-0.028241888,
-0.00057947804,
0.009475562,
-0.014095455,
0.0014496908,
-0.005078697,
-0.012368571,
-0.024316572,
0.026712544,
0.0033932324,
0.012483272,
0.000047792004,
0.02234117,
0.031122154,
0.0028308798,
-0.0024883703,
-0.017561968,
-0.0008196329,
-0.020340277,
-0.017804114,
0.0040113423,
-0.003504747,
0.009080481,
0.0037723822,
-0.01231122,
-0.03606703,
-0.004151532,
-0.04876059,
0.0064774095,
0.02012362,
0.01141273,
0.031606447,
0.0067546032,
-0.02161473,
0.022379402,
0.01354744,
0.016618874,
-0.006601669,
-0.026941946,
0.00685656,
0.010794621,
0.012795513,
-0.0009845153,
0.012706301,
-0.005171095,
0.03091824,
-0.011253424,
-0.01706493,
0.019613838,
-0.009851526,
-0.0034601411,
-0.013560184,
0.008927546,
-0.0073089907,
0.0064742235,
0.020480467,
-0.010093671,
-0.009201554,
0.00843051,
-0.007551137,
0.023424454,
-0.0005472184,
-0.0054928944,
-0.0139680095,
0.017561968,
-0.017867837,
-0.038794365,
0.017013954,
-0.029108517,
0.037876755,
0.030051613,
-0.0076148594,
0.007946217,
-0.019919708,
-0.016657107,
-0.025361624,
-0.007366341,
-0.009023131,
0.0037532654,
0.021283373,
0.005795577,
-0.023449944,
0.015764989,
-0.0055916645,
-0.014210156,
0.00023278689,
-0.027986998,
0.024036191,
-0.00685656,
-0.028981071,
0.016376726,
-0.00882559,
-0.0012521505,
-0.012037213,
-0.028802648,
-0.020200087,
-0.0021649778,
-0.00972408,
-0.005894347,
0.009959854,
0.015561077,
-0.006222519,
-0.0018925634,
-0.00003564487,
-0.0036226339,
-0.02569298,
0.038208116,
0.18688585,
-0.019703051,
-0.011043139,
0.013305294,
-0.0007176766,
0.0056840624,
0.020760847,
-0.0073408517,
-0.015204229,
-0.0031654239,
0.030816285,
-0.00060217927,
0.020047152,
0.0019116802,
0.00055797165,
-0.005148792,
-0.015892435,
-0.0065634353,
-0.008296692,
-0.004836551,
-0.000027007462,
0.0011589561,
0.024405783,
0.0030969218,
0.023182308,
0.01545912,
-0.012362199,
0.014681703,
0.020085387,
0.00233225,
-0.029159496,
0.02245587,
0.011329891,
0.0003558513,
0.014541514,
0.007175173,
-0.005884789,
-0.006327661,
-0.006818326,
-0.012699929,
0.009653985,
0.004916204,
-0.0059708143,
0.01793156,
0.003816988,
0.026890967,
-0.01191614,
-0.008857451,
0.0033964184,
-0.00006133307,
-0.025654748,
-0.015522843,
0.016236536,
0.02254508,
0.0029216846,
0.008131013,
0.0043522585,
0.0019499138,
0.01073727,
-0.007742305,
-0.02903205,
0.0032785316,
-0.029337918,
0.035149425,
-0.02107946,
0.0034155352,
-0.024303827,
0.001609794,
-0.010724526,
-0.008615306,
-0.0015325303,
-0.0067227418,
-0.018989356,
0.0038679661,
-0.0031112595,
-0.0018415853,
0.03142802,
0.0020359394,
0.021168672,
0.022723505,
-0.0054705916,
0.009755941,
-0.014018988,
0.0063085444,
-0.015076784,
-0.022213724,
0.03341617,
0.00044167778,
-0.06163257,
-0.0014226086,
-0.005868858,
-0.014834638,
-0.012738163,
-0.0047282223,
0.029439874,
-0.0058497414,
0.015675778,
-0.012457782,
-0.009908875,
0.0023051677,
-0.036092523,
0.08329828,
0.026202762,
-0.0046931747,
-0.014707193,
0.0074428082,
-0.0050213467,
-0.002456509,
0.013050403,
-0.0062830555,
0.00086423877,
-0.03336519,
0.0077040712,
-0.023577388,
-0.004556171,
0.016988464,
0.013190594,
-0.028343845,
0.018568786,
-0.021601986,
-0.007978079,
-0.031631935,
0.019091312,
0.019881474,
-0.016223792,
0.010648059,
-0.019346204,
0.014567003,
0.0050691385,
-0.033900462,
0.025654748,
-0.012891097,
-0.00639457,
0.0024915566,
0.025909638,
0.020926526,
0.03344166,
-0.008857451,
-0.015573821,
0.021920599,
-0.01565029,
-0.021436308,
-0.007200662,
-0.005712738,
0.015510098,
0.005983559,
0.005722296,
0.0138405645,
-0.017625691,
-0.015586565,
-0.010157394,
-0.03043395,
0.014668959,
-0.0067291143,
-0.001490314,
-0.03010259,
-0.020952014,
-0.028904604,
-0.004227999,
0.0024262408,
-0.018594276,
0.01821194,
-0.009035875,
-0.0032849037,
-0.011125979,
-0.0039858534,
-0.15660484,
0.011986235,
0.0030905497,
-0.011202446,
0.02133435,
0.016287515,
0.0004126043,
-0.0038329188,
0.014312113,
-0.0006483782,
0.01972854,
-0.010482379,
-0.03838654,
0.00685656,
0.026738033,
-0.020977505,
0.02903205,
0.025616514,
-0.0008865417,
0.02448225,
0.02742624,
-0.019511882,
0.0031319694,
-0.020977505,
-0.007978079,
0.024788119,
-0.009532912,
-0.015815968,
0.0030124893,
0.006066398,
-0.0125916,
-0.010189256,
0.036857195,
0.015675778,
0.028012486,
0.0046421965,
0.006515643,
-0.03308481,
-0.0028436242,
-0.0024947426,
0.025501814,
0.015357164,
-0.0036321923,
0.015025807,
-0.008921174,
0.02574396,
-0.011266168,
-0.007914356,
0.008086408,
-0.008889313,
0.006792837,
-0.009972598,
-0.011559293,
0.013356272,
0.02903205,
0.009367233,
0.0067099975,
0.007863378,
-0.014324857,
-0.021053972,
0.0006663002,
-0.023781301,
-0.0004245523,
0.018059006,
0.027120369,
-0.007270757,
0.0073344796,
0.03285541,
-0.010418657,
0.0021586055,
-0.013585674,
-0.009877014,
0.022914672,
-0.02655961,
-0.0060281646,
0.019269736,
-0.0043044663,
0.012546994,
-0.006225705,
0.020875547,
-0.012387687,
-0.01565029,
-0.046644997,
-0.025794938,
-0.0249538,
0.010463263,
0.03593959,
0.018364875,
-0.0035620974,
0.00133499,
0.0014935001,
-0.025399858,
0.0040973676,
0.00021844929,
0.0054769637,
0.00950105,
0.020136364,
0.014210156,
-0.00281017,
0.023424454,
0.008953036,
-0.017154144,
0.0014393359,
0.002646084,
-0.0039062,
-0.0106990365,
-0.04187854,
-0.0003253839,
-0.0015062446,
0.008647167,
-0.022506848,
0.017906072,
-0.0014480978,
0.01942267,
0.0050914413,
0.026967434,
-0.010348562,
-0.003957178,
-0.007538392,
-0.008322181,
0.08600012,
-0.01942267,
-0.022264702,
0.006270311,
-0.025055755,
-0.028853627,
-0.13794684,
-0.017600203,
0.024176382,
-0.010029948,
0.0010339003,
0.019435415,
0.0030825844,
0.029388897,
-0.014057222,
0.00806729,
-0.022723505,
0.03257503,
0.008634422,
-0.020990249,
0.0040177144,
0.007461925,
-0.002910533,
0.0029423945,
-0.009685846,
0.03096922,
0.0019276108,
-0.019320715,
0.014375835,
-0.024609696,
0.0074428082,
0.010546102,
-0.024469506,
0.0045147515,
0.0063690813,
0.0062352633,
0.03693366,
0.016924743,
0.03142802,
0.007914356,
-0.011673993,
-0.0036385646,
-0.009794175,
-0.03198878,
0.02816542,
-0.011559293,
-0.003383674,
0.00031084716,
0.03802969,
-0.0058306246,
-0.008099152,
0.0005093831,
-0.036984637,
-0.0003982667,
0.004489262,
-0.013853309,
-0.03336519,
-0.02434206,
-0.019652072,
-0.006502899,
0.022634294,
0.0033263236,
0.012668068,
0.023182308,
-0.017026698,
-0.0077040712,
0.013674886,
0.024520485,
-0.029465364,
0.022672527,
0.028624225,
-0.034027908,
-0.014860127,
-0.019358948,
0.0046995473,
-0.03181036,
-0.0026572354,
0.0122028915,
-0.021997066,
-0.011814184,
-0.013572929,
0.0044414704,
-0.006490154,
-0.027298793,
-0.0022063975,
-0.0029662903,
-0.031351555,
-0.002934429,
0.01627477,
-0.0016026252,
0.02819091,
0.018288407,
-0.012120052,
-0.006222519,
-0.0017109538,
0.009309882,
-0.0047154776,
0.032957368,
0.0012840119,
-0.00352705,
-0.0019531,
-0.01933346,
0.0054004965,
0.008889313,
0.024584208,
0.005269865,
-0.020633401,
-0.014719937,
-0.02982221,
0.02742624,
-0.008328553,
0.009883386,
0.011884279,
-0.016950231,
-0.00657618,
-0.038182624,
0.005706365,
0.026992925,
-0.0026843175,
0.012993053,
0.00862805,
0.010590708,
-0.03364557,
-0.013024914,
0.027579173,
0.0014313705,
0.006837443,
0.0068119536,
-0.00085707,
0.0028515896,
0.012088191,
0.0268145,
-0.032982856,
-0.009284393,
0.0048015034,
0.009953481,
-0.0037182178,
-0.0040113423,
0.009730452,
-0.027120369,
0.004925763,
0.013572929,
-0.020034408,
-0.039788436,
-0.00711145,
0.054444652,
0.022264702,
0.047741026,
-0.016070858,
-0.026330208,
0.018033516,
-0.028828137,
-0.009080481,
-0.013432739,
-0.025055755,
0.011234307,
-0.009813292,
-0.0143630905,
0.033390682,
0.012642578,
0.0027926462,
-0.031479,
-0.021104949,
0.025654748,
-0.00986427,
0.011476453,
-0.038717896,
-0.00719429,
0.006652647,
0.009628496,
0.007041355,
0.028955583,
0.014809149,
0.0038552217,
-0.033976927,
-0.013279805,
0.027528195,
0.0011557699,
-0.021066716,
-0.013764097,
0.0061396793,
-0.021398073,
0.010590708,
-0.011425476,
-0.01601988,
-0.009054991,
-0.021181416,
0.015586565,
0.00966673,
0.015089529,
-0.015968902,
0.00044805004,
0.036041543,
0.014057222,
-0.041445225,
0.03693366,
0.009615751,
-0.00809278,
-0.0016727202,
0.0003355397,
0.029108517,
0.0049225762,
0.018313896,
0.025973361,
-0.007876122,
0.009762313,
-0.012693556,
0.021066716,
0.011584782,
-0.004979927,
0.00023457909,
-0.025820427,
-0.0059325807,
-0.007289874,
-0.04185305,
-0.029592808,
-0.025272412,
0.020416744,
0.0011653284,
0.0067227418,
-0.001715733,
-0.00992162,
-0.021385329,
0.00019594721,
-0.017243356,
-0.0044956347,
0.00003997602,
0.013815075,
-0.0025266039,
0.0028834508,
-0.002622188,
0.0008331739,
0.010526986,
-0.011113234,
0.017549224,
-0.001645638,
-0.0039221304,
0.019639328,
0.024125405,
0.015153252,
-0.017409034,
0.00046597203,
-0.0061173765,
-0.03206525,
0.015535587,
0.010616197,
0.009080481,
0.05882877,
-0.013764097,
-0.011094118,
0.01039954,
-0.009054991,
0.0019945197,
-0.017727647,
0.022379402,
-0.005151978,
-0.0008427323,
0.031886827,
-0.01424839,
0.024316572,
-0.04962722,
-0.015701266,
0.020378511,
0.0047951313,
0.023985215,
0.0046103355,
-0.012120052,
0.013700374,
-0.0024421713,
0.018734466,
0.0046103355,
-0.03838654,
0.0028691133,
0.040451154,
-0.024061682,
-0.0038679661,
-0.028573247,
-0.0013628687,
-0.008812846,
-0.041190337,
-0.011718599,
0.016516916,
-0.03578665,
-0.011310775,
-0.02273625,
-0.011310775,
0.018594276,
-0.027528195,
0.0034920024,
-0.016542405,
-0.023500921,
0.0052252593,
0.009405467,
-0.0053973105,
-0.0010339003,
-0.023959724
] |
INTRODUCTION The GOLD guidelines advocate not to institute inhaled corticosteroids (ICS) in patients with mild-to-moderate COPD. However, many patients do use ICS and in some patients, withdrawal is associated with deteriorating lung function and increased exacerbation rates. Unfortunately, physicians do not know in which patients they can stop ICS treatment safely. AIM To identify predictors of COPD exacerbations after ICS withdrawal. METHODS During ICS treatment, post-bronchodilator spirometry, body plethysmography, and health status assessment were performed in 68 COPD patients using ICS. Additionally | [
-0.0037065253,
0.01578006,
0.017913217,
-0.04205366,
-0.0154620735,
0.030977145,
-0.017330242,
-0.004153693,
-0.0016926135,
0.008910235,
0.018019212,
0.008943358,
-0.013819145,
0.04457105,
-0.0037760849,
0.0034448493,
0.043299105,
0.00462736,
0.0023633654,
-0.020218616,
-0.012938059,
0.015872806,
-0.024975156,
-0.0020271614,
0.007903279,
-0.015992051,
0.023968201,
-0.028751243,
-0.014309374,
-0.013196423,
0.00821464,
-0.0059721763,
-0.008128519,
0.008327261,
-0.017767472,
-0.014985095,
0.0013133488,
-0.012169593,
-0.011109639,
-0.027267307,
0.025452137,
-0.0030175555,
-0.005773435,
0.034607485,
-0.005028155,
0.032116596,
0.022219278,
-0.022563763,
-0.029440211,
0.000317158,
0.01052004,
0.0063199736,
-0.009585955,
-0.021543557,
0.01895992,
-0.010149056,
0.004607486,
0.030076183,
0.03240808,
-0.03927128,
-0.01098377,
0.000634316,
-0.016323285,
0.041656177,
-0.0069824443,
0.018496191,
-0.00052211,
0.023212984,
0.0025538257,
0.0014234846,
0.048996355,
0.034183506,
-0.015687313,
0.019556144,
0.023106989,
0.008658496,
-0.0074329246,
-0.007962902,
0.022153031,
0.011778735,
0.017065253,
-0.0036634647,
-0.012719443,
0.03450149,
0.010665784,
0.008830738,
0.0262471,
0.0076250415,
-0.033044055,
0.007479298,
-0.0092878435,
-0.002583637,
0.030261677,
0.023000993,
-0.005912554,
-0.008969857,
0.0014971845,
0.006296787,
0.009082478,
-0.011162637,
0.0045842994,
-0.017316991,
-0.013176548,
-0.0016495528,
-0.033362042,
0.0020917521,
-0.005833057,
0.0046604834,
0.037336867,
0.008194767,
0.0032842,
0.049711823,
-0.009016231,
-0.021424312,
0.0013845644,
-0.022007287,
-0.01097052,
0.006492216,
-0.0055448823,
-0.023703214,
-0.00008550016,
-0.0008293309,
0.02675058,
-0.032540575,
-0.004077509,
-0.029228222,
-0.041762173,
-0.006333223,
-0.015038092,
-0.007797284,
-0.010202054,
0.0134680355,
0.03680689,
-0.012215965,
-0.006220603,
0.017171249,
-0.015422326,
-0.017078502,
-0.023173235,
-0.018005962,
-0.008234515,
0.021649553,
0.018005962,
-0.028830739,
-0.012255714,
0.024405433,
0.033044055,
0.0070288177,
0.0005262504,
0.008201391,
0.006747267,
-0.011984101,
-0.014256376,
-0.016031798,
0.0018731368,
-0.00010087156,
-0.009705201,
0.0125472015,
-0.023371978,
-0.024193441,
0.00079248095,
-0.029440211,
0.0062371646,
0.013063928,
0.026141107,
0.017052004,
-0.0023898643,
-0.006462405,
-0.008042398,
0.02559788,
0.0039019543,
0.019913878,
-0.014614111,
0.015157337,
0.019105664,
0.022020537,
0.009380589,
0.026220603,
0.0060251737,
-0.016561775,
-0.02490891,
0.014256376,
0.027505796,
0.0065154023,
-0.02582312,
-0.0066015236,
0.020920835,
-0.014985095,
-0.006743955,
-0.025332892,
-0.015422326,
0.035826433,
-0.04438556,
-0.019609142,
-0.6279165,
-0.0031417687,
0.031878106,
-0.012308711,
0.037283868,
0.023159986,
0.020165619,
0.0143623715,
-0.0182842,
0.027744286,
0.011699238,
0.0012355085,
0.0143491225,
0.0154753225,
0.007611792,
-0.012567075,
-0.012295462,
0.00045834715,
0.007790659,
-0.010221927,
0.016124545,
0.033971515,
0.0049221595,
0.015276582,
0.014150381,
0.007923153,
0.0015592912,
-0.03455449,
0.010467042,
0.015886055,
-0.0056045046,
0.026021862,
0.018376946,
0.015501821,
0.045816496,
-0.014375621,
-0.024749918,
-0.005561444,
0.012096721,
0.024060948,
-0.023385227,
-0.01052004,
0.03678039,
-0.019264657,
-0.008684995,
0.022537263,
0.0085591255,
0.014680358,
0.0132891685,
-0.018005962,
0.019556144,
-0.0004177708,
-0.002789003,
0.0014963564,
0.01760848,
0.0039516394,
0.0057336865,
-0.027558794,
-0.0057336865,
0.00867837,
-0.008618748,
0.015846306,
-0.029440211,
-0.0026200728,
0.0073004304,
0.000040731615,
-0.0075455448,
-0.0047466047,
0.03818483,
-0.008022524,
0.007340179,
0.024153693,
-0.007247433,
0.0066810204,
0.03338854,
-0.0042199404,
-0.004925472,
0.019622391,
0.0076647894,
0.010738655,
0.009506459,
0.007505797,
-0.014335873,
-0.0052633323,
0.023968201,
-0.0011237165,
-0.0140046375,
-0.016879762,
-0.028221264,
0.0036965883,
0.008400133,
0.018164955,
-0.00708844,
-0.024710169,
-0.0054985094,
0.018986419,
-0.0023352103,
-0.011136138,
0.016641272,
-0.016800266,
-0.0048989733,
0.0020039747,
-0.021132825,
0.027373303,
0.022762503,
-0.00006562604,
-0.04316661,
-0.022272276,
0.025836369,
-0.033706523,
0.035084464,
0.0007527327,
0.003507784,
-0.018986419,
0.010785028,
-0.019927127,
0.011897979,
-0.025982114,
-0.01874793,
-0.043723088,
0.008943358,
-0.0066578337,
0.007903279,
0.0021480622,
-0.0083670085,
0.009897317,
-0.0129049355,
-0.027558794,
0.009413714,
-0.01853594,
0.0077376612,
-0.011454124,
0.01109639,
-0.005306393,
0.02469692,
-0.015382577,
0.021411063,
-0.019039417,
-0.00902948,
-0.031639617,
-0.024564425,
-0.0060881088,
0.005332892,
-0.002666446,
-0.009877443,
-0.029731698,
-0.004862537,
0.024869163,
0.009725074,
0.009612454,
0.0067505795,
-0.025253395,
0.014865849,
0.030129181,
0.0013555813,
-0.016840013,
0.0035309705,
-0.029440211,
-0.016787015,
-0.0061344816,
-0.004206691,
0.0073931767,
-0.0010392515,
-0.025253395,
-0.019675389,
-0.010314674,
0.0045842994,
0.010599536,
0.0054521365,
-0.030950645,
0.008280887,
-0.019913878,
0.013872143,
0.00835376,
-0.0041702553,
-0.023822458,
-0.00082891685,
-0.010672408,
-0.0143491225,
-0.0042033787,
-0.0037197748,
-0.0020635973,
0.0026266975,
0.0039615766,
-0.0036700894,
0.02305399,
-0.006651209,
0.020669095,
-0.0100165615,
0.012288838,
-0.010599536,
0.016879762,
-0.000046114194,
0.0055283206,
0.011791985,
0.0005606161,
-0.0004132163,
0.0038025836,
-0.011182511,
0.010526665,
0.02351772,
-0.017012255,
0.028751243,
-0.007346804,
0.016018549,
-0.0160053,
-0.0061709173,
-0.012441206,
0.00097052,
0.0034382246,
-0.008777741,
0.00091421,
-0.0069095725,
0.018655185,
-0.012553826,
0.01739649,
0.0070288177,
-0.004700232,
0.011818483,
-0.006194104,
0.0018764492,
-0.017648228,
0.021649553,
0.00055813184,
-0.025664127,
0.011778735,
0.010142432,
-0.016866513,
0.0015940709,
-0.014123882,
-0.010149056,
0.008751242,
0.012441206,
-0.00947996,
-0.01807221,
0.031639617,
-0.011526995,
-0.02170255,
0.04022524,
-0.010486917,
-0.007479298,
0.01758198,
-0.004415369,
0.015263332,
0.0032808876,
-0.0015046373,
0.026406094,
0.011069891,
-0.0018996357,
0.01281219,
0.0040874463,
-0.017197747,
-0.010308049,
-0.009572706,
0.023822458,
-0.013163299,
0.02447168,
0.013057304,
0.02493541,
0.054693606,
0.013322292,
-0.0025306393,
0.022457767,
-0.015899304,
0.014587612,
0.0045611127,
-0.0017837032,
0.0050314674,
-0.009725074,
-0.006631335,
-0.014375621,
0.023106989,
0.0077310367,
-0.023385227,
0.03269957,
0.0074925474,
0.002611792,
0.020377608,
0.006714144,
0.022153031,
-0.00063680025,
-0.02904273,
0.036462404,
0.017158,
-0.011579993,
-0.006333223,
-0.025041405,
0.016031798,
0.017780721,
0.0410997,
-0.011984101,
0.0118317325,
-0.011341504,
0.011838357,
0.009725074,
-0.014123882,
0.0002490477,
-0.011036767,
-0.0016263664,
-0.010162305,
0.0011493872,
-0.018999668,
-0.007843656,
0.003415038,
0.005753561,
0.0073534283,
-0.019026168,
-0.028910235,
-0.018588936,
0.0069691953,
0.002770785,
-0.014918847,
0.002706194,
-0.0014317655,
-0.005988738,
0.024047699,
-0.028830739,
-0.009486585,
0.04364359,
-0.03360053,
0.0047432925,
-0.010818152,
0.01531633,
-0.021185823,
0.028936734,
-0.014561113,
-0.0062106657,
0.026578337,
0.0030490228,
0.014879099,
-0.002172905,
-0.019344153,
0.014892348,
0.0205896,
0.0026614773,
0.0064524678,
0.019688638,
0.016601523,
0.031003643,
0.040357735,
0.0031566743,
-0.013938391,
-0.0022358396,
-0.0116396155,
-0.0009340841,
0.036250412,
0.0182842,
0.033706523,
-0.00410732,
-0.013050679,
0.010679033,
-0.0014499835,
-0.004600861,
0.0015700563,
-0.02374296,
0.012692945,
-0.0051904605,
0.033892017,
-0.0027244121,
-0.0008160815,
0.015329579,
0.012600198,
-0.012851938,
-0.0074329246,
0.021649553,
-0.0008703213,
0.008526002,
0.0028850613,
0.0050115935,
-0.013090427,
-0.0136999,
0.03810533,
-0.006883074,
-0.019781385,
0.025836369,
0.003497847,
-0.01988738,
-0.037336867,
0.01919841,
0.0019807883,
0.01531633,
-0.021861544,
0.0013729712,
-0.014375621,
-0.027108314,
-0.02584962,
-0.012288838,
0.006747267,
-0.023159986,
-0.024789665,
-0.019304406,
-0.015607817,
0.0026714143,
0.010453792,
-0.009420338,
0.00037698742,
-0.011109639,
0.020205365,
0.01988738,
0.016614772,
0.02102683,
-0.014494866,
-0.006558463,
0.013792646,
-0.0087379925,
0.00029335046,
0.010480291,
-0.024047699,
-0.004836038,
0.0034315998,
0.011235508,
0.010513415,
-0.03794634,
0.05077178,
0.0016545213,
-0.015581318,
-0.015965551,
-0.013130176,
0.016614772,
-0.0011990726,
0.019132163,
0.020337861,
-0.017250745,
-0.04271613,
0.0005498509,
-0.0055018216,
-0.025942365,
-0.033282544,
0.001921166,
0.0065154023,
0.008168268,
-0.015687313,
0.024100695,
-0.0018781053,
0.004190129,
-0.018641934,
-0.011262007,
-0.020841338,
0.0053991387,
0.018350447,
-0.018482942,
0.020470355,
-0.0031169262,
-0.0154488245,
0.0070950645,
0.011818483,
0.03288506,
0.016058298,
-0.03704538,
-0.008155018,
-0.0029778073,
-0.010864525,
-0.045842994,
-0.017952964,
-0.020046374,
0.019185161,
0.009976814,
-0.021344816,
-0.04748592,
0.021199072,
-0.008943358,
0.013295793,
-0.009579331,
-0.03222259,
0.0072010597,
-0.00055440544,
-0.006038423,
0.010639285,
0.024127195,
-0.029360715,
-0.0053130174,
0.011016893,
-0.01644253,
-0.0042497516,
-0.039377276,
-0.0114607485,
-0.020165619,
0.00049271283,
-0.018681683,
-0.024590924,
0.012626697,
-0.009877443,
-0.0015245114,
0.03407751,
0.031586617,
-0.0046671084,
0.010765154,
-0.0068631996,
-0.005491885,
0.004027824,
-0.00993044,
0.0014019543,
-0.011275257,
0.022908248,
0.017489234,
-0.015581318,
0.0075985426,
0.0007585293,
0.0013083803,
-0.01669427,
-0.024113946,
-0.011189136,
-0.02308049,
-0.029996688,
-0.034236502,
-0.00084672077,
0.023040742,
-0.0053593908,
-0.036833387,
-0.00067199406,
0.009691951,
0.006276913,
0.003703213,
-0.013554157,
0.019383902,
-0.021066578,
0.028830739,
-0.011632991,
-0.008247764,
-0.011467373,
-0.0062371646,
-0.008989732,
-0.009923816,
0.007214309,
-0.0035905929,
0.017939715,
0.0046671084,
0.0015162305,
-0.00731368,
0.012679695,
-0.032328587,
0.01156012,
-0.016389534,
-0.040834714,
0.016071547,
-0.027161311,
0.01040742,
0.001753892,
0.010592911,
0.0050579663,
0.015713813,
0.03156012,
-0.03222259,
0.0034183504,
0.008386883,
-0.024882412,
0.01990063,
-0.009764823,
0.037893344,
0.02832726,
-0.017873468,
-0.011010269,
-0.011129513,
-0.005700563,
-0.02263001,
-0.010824776,
0.0273998,
-0.022232527,
0.022537263,
-0.019927127,
0.014508115,
-0.027373303,
-0.016164294,
0.013964889,
0.0072010597,
0.0020105995,
-0.016098045,
-0.023067242,
-0.03216959,
0.0274263,
-0.0051341504,
0.004657171,
0.00019108149,
-0.0194369,
0.0066578337,
-0.003749586,
-0.011288506,
0.014812852,
0.0039880755,
0.023610467,
-0.0064524678,
-0.0009870818,
-0.022709506,
0.011162637,
0.00096555153,
0.030076183,
0.0021050016,
0.0026747268,
0.007678039,
0.01739649,
-0.0049585956,
0.011387877,
-0.012606824,
0.03407751,
0.0064524678,
-0.0004823617,
0.005982113,
-0.02054985,
-0.00026560947,
-0.029228222,
-0.010712156,
0.006724081,
-0.0037528984,
0.012143094,
0.030102683,
0.033706523,
-0.05077178,
0.0047996026,
0.0017936403,
0.002732693,
0.02558463,
-0.018376946,
0.0049585956,
-0.03354753,
0.006995694,
-0.02035111,
-0.012043723,
0.010115933,
0.004842663,
-0.015568069,
0.019728387,
0.00405101,
-0.018800927,
0.008294137,
0.026472341,
-0.0057668104,
-0.006535277,
0.003925141,
-0.03185161,
-0.043988075,
-0.0036303413,
0.007797284,
-0.043908577,
-0.014243127,
0.000064590924,
0.0005494369,
0.008314012,
0.010698907,
-0.0024561114,
0.03542895,
-0.0016031798,
-0.01291156,
-0.02790328,
0.0072010597,
-0.03179861,
0.0012239153,
0.04253064,
-0.027611792,
0.003805896,
-0.0121894665,
0.037840344,
0.014203379,
-0.013077178,
0.0007974495,
-0.01371315,
0.0274263,
-0.025200397,
-0.015713813,
-0.009897317,
0.0012421332,
-0.0136469025,
0.030420668,
0.012454455,
0.0018151706,
0.0050844653,
-0.023464723,
0.020006625,
-0.008704869,
-0.024259688,
-0.007360053,
-0.00291156,
0.02467042,
-0.03638291,
0.0039052668,
-0.001231368,
0.031242134,
0.019463398,
-0.026207354,
-0.027717788,
-0.0055183833,
-0.035587944,
0.0067837033,
-0.028671745,
0.030685658,
-0.001995694,
-0.006531964,
-0.013779397,
0.03309705,
0.0057634977,
-0.000020042336,
-0.022696257,
-0.02582312,
-0.0016685989,
-0.009486585,
0.016124545,
-0.01109639,
-0.02282875,
0.027479298,
0.007061941,
0.0040344484,
-0.016376283,
0.0205896,
0.011076516,
-0.018787678,
-0.021649553,
-0.013673401,
-0.023848956,
0.003517721,
-0.010023187,
-0.019953627,
0.00011893425,
0.030526664,
-0.012156343,
-0.0052169594,
0.0068168268,
0.01645578,
-0.013567407,
-0.013501159,
0.0051705865,
-0.0125736995,
-0.02219278,
-0.006528652,
0.008386883,
0.022722756,
0.009731699,
0.004385558,
-0.0018913548,
0.010049685,
-0.031878106,
0.021450812,
0.016111296,
-0.017065253,
0.01552832,
-0.026631335,
-0.016363034,
0.021808546,
0.0034481615,
0.009446837,
-0.010685657,
-0.024763167,
0.016296787,
-0.00046787015,
0.025346141,
0.011533621,
-0.0051639616,
0.01098377,
0.0073931767,
0.0025057967,
-0.009002981,
-0.016946008,
-0.0012628353,
-0.039059293,
0.022775754,
-0.020655846,
-0.022775754,
0.020231865,
-0.0049751573,
-0.027108314,
0.033998013,
0.024604173,
0.20870487,
-0.02032461,
-0.0025223584,
0.019807883,
0.0034481615,
0.009340841,
0.017091753,
0.0041470686,
-0.02077509,
0.016018549,
0.022947997,
-0.006995694,
-0.03450149,
0.0046902946,
0.009181849,
0.0019559457,
-0.0136336535,
-0.022418018,
-0.008068897,
-0.001688473,
-0.015329579,
0.013938391,
0.010009937,
0.000042387794,
0.045763496,
-0.0061510433,
-0.01646903,
-0.0039980127,
0.016416032,
0.02305399,
0.0031782046,
0.015872806,
0.0052732695,
0.012626697,
-0.0143491225,
-0.029360715,
0.01853594,
-0.0037827096,
-0.0048526004,
0.022312025,
-0.012083472,
-0.010274925,
-0.02766479,
-0.021596555,
-0.018694932,
0.019754887,
0.012891686,
-0.007134813,
-0.02172905,
0.005250083,
-0.01966214,
-0.019317655,
0.023133488,
0.03108314,
0.010115933,
-0.015342829,
0.016164294,
0.0036866511,
-0.01782047,
-0.012533952,
-0.016389534,
0.012659821,
0.010930772,
0.027717788,
-0.012070222,
0.030076183,
-0.0056939386,
-0.014998344,
-0.029334217,
0.0028469693,
0.02856575,
-0.011917854,
-0.027267307,
0.012341835,
-0.015369328,
-0.0143623715,
-0.011129513,
0.016270287,
-0.0033521033,
0.018880423,
-0.015660815,
0.029652203,
-0.025332892,
-0.008711494,
-0.03977476,
-0.022802252,
0.0062272274,
-0.006896323,
-0.06794303,
0.013408413,
-0.005071216,
-0.016601523,
-0.015395827,
0.0052368334,
0.034263,
0.010142432,
-0.007929778,
-0.005568069,
-0.0007721928,
0.012315337,
-0.028009275,
0.08113945,
0.0008280888,
-0.00094650546,
-0.00010651292,
0.017409738,
0.010387545,
0.010778404,
-0.015024843,
-0.013547532,
0.030712156,
-0.021318316,
-0.014402119,
-0.017754223,
0.008883736,
0.007154687,
0.008267638,
-0.004551176,
-0.0072076847,
-0.021623055,
0.014879099,
-0.011566744,
-0.015051342,
0.008148394,
0.008784366,
-0.009638953,
-0.006372971,
-0.011315005,
-0.014786353,
-0.039986752,
-0.005140775,
-0.028645247,
0.018615436,
-0.008194767,
-0.005985426,
0.015607817,
0.017780721,
-0.025266645,
-0.0020453793,
0.0073733022,
0.0043491223,
0.0015435575,
0.029175224,
-0.005799934,
0.03309705,
0.000032450727,
-0.005756873,
0.011109639,
-0.006349785,
0.008579,
-0.01919841,
0.008976482,
0.011970852,
-0.012732693,
0.026459092,
-0.02904273,
0.012249089,
-0.025147399,
0.0051341504,
0.017184498,
-0.012514077,
0.01620404,
0.011334879,
0.0059754886,
-0.006697582,
-0.00490891,
-0.16620073,
0.02558463,
0.01624379,
-0.0057038753,
0.03405101,
0.00050223584,
0.02832726,
-0.008896986,
-0.010096058,
-0.023875456,
-0.0039516394,
0.042848624,
-0.013083803,
-0.018390195,
0.01050679,
0.014031136,
-0.018602187,
0.018628685,
0.025942365,
0.01852269,
0.03132163,
-0.03219609,
0.0018267639,
-0.03036767,
-0.008605499,
-0.030473666,
-0.010029811,
0.00076556805,
-0.0019393839,
-0.011401126,
-0.03521696,
0.0029446837,
0.036674395,
0.000011120974,
-0.008314012,
0.007638291,
-0.01670752,
-0.009493209,
-0.008830738,
0.013030805,
0.042159654,
0.016654521,
0.012613448,
0.008645247,
-0.027956277,
-0.004186817,
-0.0059191785,
0.011851607,
0.009884068,
0.00016282295,
0.013938391,
-0.012944683,
-0.00846638,
0.003749586,
-0.027929777,
-0.003461411,
0.00971845,
0.0062172906,
-0.004988407,
-0.02054985,
0.0021149388,
-0.015939053,
-0.008121895,
-0.006200729,
0.02696257,
-0.03338854,
0.011540245,
0.0042133154,
-0.011142762,
0.033468034,
0.010539914,
-0.007154687,
-0.0012321961,
0.007770785,
0.043034118,
0.009347466,
-0.01039417,
0.014070884,
0.013415038,
0.012673071,
0.0018400132,
0.0056011924,
-0.028830739,
0.015488572,
0.0018482942,
0.04253064,
0.028618747,
0.020669095,
-0.013256045,
0.00075231865,
0.010162305,
-0.026565088,
-0.0043060617,
0.0029827757,
-0.01279894,
0.036833387,
0.0035740312,
-0.014243127,
-0.0059986752,
-0.02011262,
0.019913878,
-0.01808546,
-0.021623055,
-0.013567407,
0.039218284,
-0.027850281,
-0.02329248,
0.016310036,
0.029758198,
-0.028963232,
-0.00017772855,
0.024577675,
0.013766148,
0.017674727,
0.00033413383,
0.014614111,
-0.016826764,
-0.012653196,
-0.00520371,
-0.040331237,
0.031109639,
0.0055018216,
-0.0154753225,
-0.008585624,
-0.033070553,
-0.015289831,
-0.120622724,
-0.031401128,
0.026856575,
-0.025717124,
-0.0078039085,
0.014110632,
-0.018853925,
0.0058959923,
-0.008923485,
0.009811196,
0.0054819477,
-0.02147731,
-0.0037197748,
-0.003246108,
0.034633983,
-0.005412388,
-0.0015096058,
-0.037840344,
-0.003991388,
0.034263,
0.0026548526,
-0.020059623,
0.0049188472,
-0.011427625,
-0.0010963895,
-0.041073203,
0.003852269,
0.028486254,
-0.0037164623,
0.029572707,
0.024590924,
0.011897979,
0.02928122,
0.0059390524,
-0.023530971,
-0.017277244,
0.0015079497,
-0.02354422,
0.047379926,
-0.013355415,
0.014985095,
0.03171911,
-0.0018698245,
-0.008088771,
0.0094534615,
-0.018681683,
-0.029360715,
0.014879099,
0.014773103,
0.0015361047,
-0.01736999,
-0.044597548,
-0.014892348,
-0.0075985426,
-0.005048029,
0.022669759,
0.011917854,
0.017966215,
-0.0012437893,
0.019953627,
0.018111957,
0.011315005,
-0.012388208,
0.01714475,
0.012792315,
-0.01942365,
0.0028966544,
-0.021980789,
0.011586618,
-0.01877443,
-0.025465386,
-0.012885061,
-0.0364889,
-0.00214475,
-0.029811196,
-0.005385889,
-0.008208016,
-0.0036601524,
-0.0087247435,
-0.025743624,
-0.014547864,
-0.025346141,
0.022497516,
-0.033229545,
0.025664127,
0.034660485,
0.011666114,
0.007605167,
-0.019079166,
-0.03980126,
0.01234846,
0.019516395,
0.017793972,
-0.023411727,
0.00040307222,
0.011990725,
-0.021583306,
-0.0053395163,
0.018019212,
0.025478635,
0.008095396,
-0.0036999006,
-0.048572376,
0.023623716,
0.014455117,
0.015104339,
0.0004939549,
-0.033441536,
0.017330242,
0.003201391,
0.0036303413,
-0.0038853926,
-0.023941703,
0.008896986,
0.0022673071,
0.0120105995,
-0.024259688,
-0.01693276,
0.028406758,
0.0013655184,
0.016654521,
-0.016482279,
-0.018019212,
-0.014190129,
0.034342498,
0.011348128,
-0.0025670752,
-0.0010773435,
-0.000012531312,
0.02443193,
-0.0011866512,
-0.007267307,
-0.0018482942,
-0.01281219,
-0.0044054324,
-0.007108314,
-0.010559788,
-0.018443193,
0.014799602,
0.025770122,
0.015992051,
0.023848956,
0.011970852,
-0.032567076,
0.02101358,
0.0018085459,
0.0050149057,
0.008015899,
-0.040808216,
0.050692283,
0.0101689305,
-0.011016893,
0.0012437893,
-0.011851607,
0.024749918,
-0.032752566,
-0.002078503,
-0.0070950645,
0.033653527,
-0.0009506459,
-0.023385227,
-0.015992051,
0.015793309,
0.0036800264,
0.009937066,
-0.014680358,
0.02374296,
0.016999006,
-0.011579993,
-0.010460418,
-0.0009589268,
-0.005197085,
-0.024723418,
-0.011023518,
-0.009897317,
-0.0077177873,
0.028062273,
0.0032047036,
-0.000895164,
-0.0039682016,
-0.0015336204,
-0.006147731,
0.02490891,
-0.0018979794,
-0.0076979133,
0.0073269294,
0.016654521,
0.028141769,
-0.022510765,
0.01462736,
-0.029890692,
0.010387545,
0.0042033787,
0.001632991,
-0.0148526,
0.0018781053,
0.026260352,
0.020523353,
-0.008439881,
-0.011487247,
-0.008843988,
0.01578006,
0.005402451,
0.008473004,
-0.00708844,
-0.025293143,
-0.005157337,
0.005644253,
-0.016336536,
-0.043802585,
-0.021464061,
0.000054136304,
0.011950977,
0.016720768,
0.00016013166,
0.0022308712,
-0.009599205,
0.009983438,
-0.006223915,
-0.024021199,
0.0067837033,
0.0003150878,
-0.0004956111,
0.0060748593,
-0.011056641,
0.0022590263,
0.0051474,
-0.011016893,
0.03039417,
-0.0049221595,
0.027028818,
0.01690626,
0.019913878,
-0.017648228,
-0.04041073,
-0.019330904,
0.020735342,
-0.022497516,
-0.01312355,
0.006902948,
-0.013991388,
0.075733684,
0.020205365,
-0.024352435,
-0.0006893839,
0.013176548,
0.023729712,
-0.019052666,
0.014441868,
-0.0024196755,
-0.028698245,
0.009075853,
-0.011156012,
-0.0038953295,
-0.025478635,
-0.014720106,
0.0018052335,
-0.0029728387,
0.008598873,
0.025240146,
-0.0062272274,
0.018986419,
-0.009221597,
0.021517059,
-0.02312024,
-0.016747268,
-0.011361378,
0.017237496,
-0.0040609473,
-0.02513415,
-0.012673071,
0.012514077,
0.014561113,
-0.025412388,
-0.012977807,
0.032328587,
-0.006790328,
-0.0072606825,
-0.015276582,
0.015819808,
0.002817158,
-0.029095728,
0.0039350777,
-0.030208679,
-0.0065419013,
-0.013521033,
-0.0092878435,
0.0022722755,
-0.0012802252,
-0.00856575
] |
PURPOSE Peroxisome proliferator-activated receptors (PPAR) regulate lipid and glucose metabolism but their anticancer properties have been recently studied as well. We previously reported the antimetastatic activity of the PPARalpha ligand, fenofibrate, against melanoma tumors in vivo. Here we investigated possible molecular mechanisms of fenofibrate anti metastatic action. EXPERIMENTAL DESIGN Monolayer cultures of mouse (B16F10) and human (SkMell88) melanoma cell lines, soft agar assay, and cell migration assay were used in this study. In addition, we analyzed PPARalpha expression and its | [
-0.009695435,
-0.023054644,
-0.0075039547,
-0.0417399,
-0.020137195,
0.017938929,
-0.037479065,
0.006706744,
-0.036637753,
-0.01730116,
0.019472286,
0.017246883,
0.012863922,
0.0039385585,
-0.021331314,
0.018047486,
0.03137277,
-0.0076600043,
-0.010516392,
0.01614775,
-0.011174515,
0.014424419,
-0.0067881616,
-0.0237874,
-0.0026426676,
0.0075107394,
0.01146626,
-0.053871065,
-0.013881638,
-0.020055776,
0.012483975,
0.0022695053,
0.0032312463,
0.013596677,
0.005417638,
0.0024984912,
0.016609114,
-0.0042913663,
0.0011356007,
-0.021969082,
-0.00036574146,
-0.011696942,
0.006469277,
0.0025985665,
-0.0067508454,
-0.002929324,
0.012232939,
-0.010150014,
-0.018468142,
0.022661129,
0.004827363,
0.015632108,
-0.014627962,
-0.003044665,
0.0033211445,
-0.0012127775,
0.01731473,
0.031155659,
-0.012762151,
-0.024343751,
-0.0054685236,
0.009485107,
-0.024018083,
0.014546544,
0.006927249,
0.02028646,
0.011459474,
0.02380097,
-0.0051496397,
0.0035993198,
0.019648692,
0.025144354,
-0.009946471,
-0.015469274,
0.008406329,
-0.008874478,
-0.031508468,
0.01910591,
-0.0124500515,
0.018725963,
0.036583476,
-0.0056686746,
0.0036128894,
0.028794559,
0.025117215,
-0.013705233,
-0.0061198617,
0.013121744,
0.009912548,
-0.0028445143,
0.022254042,
0.029093089,
0.03490085,
0.002629098,
-0.00820957,
0.020937797,
0.002479833,
0.003353372,
-0.006123254,
-0.02674556,
0.02846889,
0.017952498,
-0.021819817,
-0.011730866,
-0.012199014,
-0.0032244616,
-0.010787782,
-0.0025883894,
0.033109672,
-0.0024950989,
-0.02290538,
0.027708996,
0.007890686,
-0.027234063,
0.01277572,
-0.007836408,
0.0071850703,
0.0021643413,
-0.0017962676,
-0.003097247,
0.011215223,
0.027193354,
0.02616207,
0.008270633,
0.04619071,
-0.015320009,
0.0023169986,
-0.016676962,
-0.03319109,
0.00675763,
0.018943075,
0.0069238567,
0.009424044,
-0.01335921,
-0.016161319,
0.006455708,
-0.03443949,
-0.005441385,
-0.028713142,
-0.02233546,
0.00014237413,
0.021548426,
0.0025527694,
-0.0015257249,
-0.01992008,
0.0070290207,
0.02586354,
0.005454954,
0.0024509977,
0.0020608737,
0.0020693545,
-0.03237692,
0.012104028,
-0.009647941,
-0.0011042211,
-0.012083674,
0.012897846,
0.025632856,
-0.0076803584,
-0.015550691,
0.027369758,
-0.00853524,
0.0071511464,
0.015903499,
-0.0030293993,
0.034466628,
0.004298151,
-0.004596681,
-0.023312466,
-0.018766671,
0.013963055,
0.03175272,
-0.008114584,
0.039324522,
-0.019010922,
0.006730491,
-0.01970297,
0.0036569906,
-0.0029530707,
0.005407461,
-0.02025932,
0.012212584,
0.020028638,
-0.0071307924,
0.0053803218,
-0.009607233,
0.021032784,
-0.013637385,
0.00047281358,
-0.043856747,
0.010821707,
0.024303043,
-0.015387856,
-0.025809262,
-0.61833674,
-0.019323023,
0.015754234,
-0.013237084,
0.0028004134,
0.030368626,
0.020191472,
-0.01643271,
-0.022484725,
-0.0033313215,
-0.004260835,
0.012375419,
0.03555219,
-0.014492267,
-0.02324462,
-0.024099499,
-0.019458717,
-0.023081783,
0.014899353,
-0.008908401,
-0.009559739,
0.004640782,
0.007904256,
0.005743307,
-0.0023882387,
0.02171126,
0.039188825,
-0.005210703,
0.005604219,
0.03935166,
-0.03313681,
0.050912905,
-0.006147001,
-0.0038130402,
0.04817186,
-0.011568031,
0.0027546163,
0.02175197,
0.040790033,
0.04350394,
-0.010116091,
0.022484725,
0.021182049,
-0.00130522,
-0.02966301,
0.010923478,
0.030504322,
0.0028750459,
0.0196894,
0.03609497,
-0.0066355043,
0.026243487,
-0.03237692,
0.0067745917,
0.017219745,
0.007754991,
0.036556337,
-0.024493016,
-0.0042574424,
0.026270626,
0.015347147,
0.007849977,
0.0055092326,
-0.05704634,
-0.024764407,
0.032919697,
-0.013779866,
0.008813415,
0.0035009407,
-0.010468898,
0.027532592,
0.03199697,
-0.009437614,
0.008928756,
0.035335075,
0.009736143,
0.0051564244,
0.034792297,
-0.018128904,
0.0074768155,
0.015672816,
0.017124757,
-0.039270245,
0.009973611,
0.021480579,
0.0047425535,
-0.026352042,
0.013678094,
0.026107792,
0.0037044839,
0.016894074,
-0.019255174,
-0.018820949,
-0.025361467,
-0.0043863533,
0.020829242,
-0.01409875,
0.002576516,
-0.0071986397,
-0.030748572,
-0.023882387,
-0.018685253,
0.015781373,
-0.00852167,
0.023909526,
-0.021602705,
-0.04502373,
-0.02704409,
0.017260453,
-0.04966451,
0.018590268,
-0.025171492,
-0.0033567646,
-0.018888798,
0.0022864672,
-0.021616274,
0.014546544,
-0.0055024475,
-0.0050512603,
-0.03443949,
0.015727095,
-0.0078092692,
-0.006862794,
0.012321141,
0.022457585,
0.014858644,
0.00088541233,
-0.016894074,
0.0052005253,
-0.009790421,
0.007748206,
0.012545038,
0.006839047,
-0.01351526,
0.02350244,
0.0058281166,
0.008813415,
0.010482468,
0.005258196,
-0.026053512,
-0.0288217,
-0.008026382,
-0.007877117,
-0.0045593646,
0.023108924,
-0.011065958,
-0.013908776,
0.0028716535,
-0.009742929,
0.008657365,
-0.00012148977,
-0.0058722175,
-0.020544281,
0.023407454,
0.031834137,
-0.008698074,
0.020150764,
-0.022199765,
-0.017192604,
0.00006493236,
-0.0072936267,
-0.008888047,
-0.019431578,
-0.0006458252,
-0.0015248768,
-0.020503571,
0.0019998106,
0.003626459,
-0.0051598167,
-0.03433093,
-0.012056534,
-0.0041692406,
-0.014845074,
0.0067745917,
-0.009044097,
0.015917068,
-0.004647567,
-0.016012054,
-0.017124757,
0.0029530707,
0.00014619056,
0.007470031,
-0.005163209,
0.009749713,
0.028984534,
0.0100414585,
0.024316613,
0.024764407,
-0.009797206,
0.012572177,
-0.014885783,
0.01996079,
0.007666789,
0.012945339,
-0.017572552,
-0.022959659,
-0.0064387457,
0.002427251,
-0.009614018,
0.02966301,
0.004298151,
-0.0428526,
0.019024493,
-0.025442883,
0.016975492,
-0.011744435,
-0.009057666,
-0.00968865,
0.013189591,
-0.006062191,
0.0055736876,
0.0016877113,
-0.026026374,
-0.0067881616,
-0.0005932432,
-0.0023509224,
-0.009695435,
-0.012375419,
0.0050682225,
-0.036827724,
-0.0064964164,
-0.0002064054,
0.008012813,
0.005047868,
-0.007985673,
0.00038312742,
0.01498077,
0.015075757,
-0.003185449,
-0.005546549,
-0.010984541,
-0.005604219,
0.00285978,
0.014302293,
0.0062148483,
-0.0073818285,
0.02317677,
-0.016378433,
0.028007526,
-0.005302297,
0.0214263,
0.018698823,
0.027261201,
0.022823963,
-0.008603087,
-0.010414621,
0.017966067,
0.031209938,
-0.014315862,
0.008555594,
0.007863548,
0.016392002,
-0.011493399,
0.0129996175,
0.017165465,
-0.006944211,
0.0062318104,
0.012266862,
0.0370177,
0.012463621,
0.02698981,
-0.0054040686,
-0.012646809,
0.0006759326,
0.0076532196,
0.012741796,
0.007849977,
0.0105503155,
-0.0170162,
0.0027223886,
-0.0152793,
-0.0036196744,
0.03473802,
-0.045132283,
0.001747078,
0.010278925,
0.011717296,
-0.009770067,
0.032811143,
0.0098311305,
-0.015455704,
-0.0417399,
0.041902732,
0.0072325636,
-0.012511114,
-0.027410466,
-0.04439953,
0.011032035,
0.00035789656,
-0.008046736,
0.0076735737,
0.011384842,
0.016297014,
0.0025866933,
-0.022620419,
-0.021670552,
0.025117215,
-0.012002257,
0.036556337,
-0.0036128894,
-0.0059672045,
-0.0006784769,
0.0076192957,
-0.007422537,
0.056774948,
0.009926117,
-0.00048044644,
-0.02290538,
-0.006713529,
-0.021928374,
0.0193773,
-0.00031527973,
0.0045254407,
-0.0075107394,
-0.004233696,
0.010116091,
-0.015699955,
-0.0005215791,
0.021331314,
-0.01012966,
-0.017138327,
-0.020164333,
0.016378433,
0.010414621,
0.018047486,
0.015089327,
0.023814538,
-0.014058041,
0.012504329,
0.0046306048,
-0.000093820636,
0.005984166,
0.008101014,
-0.008216355,
0.009580093,
-0.0066592507,
-0.007985673,
0.0008459759,
0.017287591,
0.012483975,
-0.024004513,
-0.024696559,
-0.018902367,
-0.009586879,
0.0038096479,
-0.017857512,
0.054468125,
0.025768552,
0.01441085,
-0.0049019954,
0.011283071,
0.0146686705,
0.01673124,
-0.006133431,
-0.010970972,
-0.005129285,
0.014750088,
0.020476433,
-0.008528454,
-0.037370507,
-0.0017012808,
-0.016514128,
0.00043104484,
0.0063912524,
-0.0029310202,
0.003731623,
0.0023068215,
-0.0059095337,
0.0045593646,
-0.011656233,
-0.013800221,
0.009491892,
0.002725781,
-0.017776094,
0.019770816,
-0.016758379,
-0.0146686705,
-0.010292495,
0.003141348,
0.0018149257,
0.0040437225,
0.0057908003,
-0.019485857,
0.003504333,
0.010306064,
-0.014478697,
0.019309452,
-0.016880505,
0.011744435,
0.0041895946,
0.0052717654,
-0.030612879,
-0.01617489,
0.017531844,
0.011052389,
-0.03023293,
-0.013420273,
0.009790421,
0.0046306048,
0.010597809,
0.018115332,
-0.03226836,
0.0006377683,
0.03905313,
-0.0067474525,
-0.009044097,
0.007402183,
-0.03462946,
0.01042819,
-0.008731998,
0.012578961,
-0.022091208,
-0.025768552,
0.008643796,
0.0044168844,
-0.018576698,
-0.00022220118,
-0.026623433,
-0.023719553,
0.009444399,
-0.007320766,
0.01821032,
0.0132303,
0.00057755347,
-0.0031379557,
-0.010421406,
-0.008731998,
-0.027763275,
-0.004332075,
-0.0030480574,
0.010529961,
0.00065345806,
-0.021222757,
-0.010672442,
0.00176404,
0.0042947587,
-0.01307425,
-0.016378433,
0.023977373,
0.017884651,
-0.024533724,
0.029717289,
-0.009030527,
-0.0150486175,
-0.0012042965,
-0.00040708613,
0.020490002,
0.014940062,
-0.019811526,
-0.0074089677,
-0.014356571,
-0.012836783,
-0.01673124,
0.00026227374,
-0.009179792,
0.038700324,
-0.028061805,
-0.033706732,
-0.027383327,
0.0011610436,
-0.03026007,
-0.02762758,
-0.010665657,
0.008779491,
-0.013257438,
0.010360342,
0.009892194,
-0.011859776,
0.0137188025,
-0.03199697,
-0.019268744,
-0.0017708247,
-0.01277572,
0.02290538,
0.00052073103,
0.009111945,
-0.025049368,
-0.011018465,
-0.038564626,
-0.021874094,
-0.018332446,
-0.029880123,
0.038021844,
0.038863156,
0.023882387,
0.0050512603,
-0.0015927245,
-0.0020761392,
-0.0049868054,
-0.0096615115,
-0.016392002,
0.01907877,
-0.0068322625,
0.024642281,
0.012368634,
-0.0059332806,
0.02115491,
-0.01641914,
0.021032784,
0.0071782856,
-0.028387474,
-0.011588385,
-0.0061707473,
0.015143604,
-0.039568774,
0.008888047,
-0.016392002,
-0.005163209,
-0.028604586,
-0.032702588,
0.027546162,
-0.0064726695,
0.014125889,
0.011717296,
0.02465585,
-0.02876742,
0.030721433,
-0.007090084,
0.0017979637,
-0.0065303403,
-0.020652836,
0.007463246,
-0.027478315,
-0.0067881616,
0.0028275524,
0.013101389,
0.0060587986,
-0.0129996175,
0.0012712961,
0.010326418,
-0.005600827,
0.0042574424,
-0.0006051166,
-0.020937797,
-0.011615524,
-0.0007420841,
-0.016378433,
-0.042418376,
-0.012755366,
0.025822831,
-0.028903116,
0.018848088,
0.0026053514,
-0.023271758,
0.023746692,
-0.01173765,
0.0217384,
-0.013460982,
0.018413862,
0.014655101,
0.002744439,
-0.01878024,
-0.0025171493,
-0.010299279,
-0.018535988,
0.035063688,
0.005329436,
-0.011350919,
-0.012979263,
-0.01162231,
0.014817935,
-0.026514877,
-0.028658865,
0.011425551,
-0.008813415,
0.006079153,
-0.01441085,
-0.009037312,
-0.036474917,
0.00067169213,
-0.021629844,
0.019241605,
-0.0050512603,
-0.012083674,
-0.0111202365,
0.022864671,
-0.002557858,
0.0004100545,
-0.00227629,
-0.025456453,
0.01044176,
-0.011228792,
-0.00012042965,
0.008765922,
-0.007999242,
0.03815754,
0.0012314356,
-0.00322955,
0.0043524294,
0.015903499,
0.0053158663,
-0.0118937,
-0.010333203,
0.04087145,
0.017572552,
0.017816802,
0.022511864,
0.004220126,
0.02849603,
-0.0050342986,
-0.0057399147,
-0.032404058,
-0.011561247,
0.00631662,
0.015143604,
0.016948353,
-0.022539003,
0.016948353,
-0.023000367,
-0.004162456,
-0.026921963,
-0.0111202365,
0.020245751,
-0.026854116,
-0.0017911791,
-0.005566903,
-0.0047764773,
0.028930254,
0.00083876704,
-0.0013823967,
-0.0051903483,
0.00674406,
-0.027790414,
0.021195618,
-0.0014315862,
0.008989819,
-0.026609864,
0.008942326,
-0.016894074,
-0.040464364,
0.010604594,
-0.00469506,
-0.040057275,
-0.02176554,
-0.011900485,
0.0025391998,
0.015102896,
-0.030884268,
0.023163201,
0.017681109,
0.0105571,
-0.010346773,
0.013617031,
-0.009139084,
-0.023719553,
0.024805116,
0.030450044,
-0.011771575,
-0.021100631,
-0.014003763,
-0.023027506,
0.0024374283,
0.004728984,
0.0030989433,
-0.028116083,
0.016269876,
-0.025944958,
-0.0065235556,
-0.010217862,
-0.01731473,
-0.0023169986,
0.023855248,
0.011683372,
-0.01730116,
-0.025727844,
0.0014264977,
-0.008345266,
-0.01192084,
-0.040057275,
-0.01587636,
-0.019228036,
-0.008447037,
-0.021290606,
-0.012097243,
-0.025646428,
0.050071593,
-0.0013349033,
-0.027071228,
-0.018698823,
-0.005125893,
-0.025659997,
-0.036366362,
-0.003309271,
0.028713142,
-0.015102896,
0.012891061,
-0.0014595734,
0.011079527,
0.0111813,
-0.011975117,
-0.007598941,
-0.037099116,
0.013250654,
-0.044562362,
0.042961158,
-0.0147093795,
-0.030422904,
-0.017789664,
0.041061424,
-0.029310202,
-0.0100414585,
0.015659247,
-0.014370141,
0.004589896,
-0.02081567,
0.015225022,
0.02586354,
-0.0031328672,
0.027654719,
-0.033055395,
0.023136063,
0.03503655,
0.007944965,
-0.0063573285,
-0.008596302,
0.00012562424,
0.008175647,
0.019825095,
0.0076260804,
-0.019160187,
0.015699955,
0.0018115334,
-0.003999621,
-0.013298147,
0.006455708,
0.011601955,
0.008006027,
-0.027817553,
-0.007612511,
-0.004976628,
-0.0038774954,
0.0049257423,
0.010095736,
0.023651704,
-0.008080659,
-0.001022804,
-0.0055261943,
-0.019051632,
0.005549941,
-0.016704101,
-0.00077176746,
-0.01792536,
0.036067832,
-0.010848845,
0.004427062,
-0.028007526,
-0.0018081409,
0.0008243494,
-0.0026698066,
-0.012667163,
0.0050207293,
-0.00079466606,
-0.0040064063,
0.007992458,
-0.0036230667,
0.0120701045,
0.011805498,
-0.01321673,
0.002055785,
0.016310584,
0.18280882,
-0.0027393505,
0.012592531,
0.026569156,
0.0014578772,
0.00791104,
0.0075039547,
0.0064455303,
-0.0019726716,
0.011934409,
0.014505836,
-0.012205799,
-0.010034673,
-0.0029089698,
0.024710128,
0.024493016,
-0.02171126,
0.0046068584,
-0.02200979,
-0.025035797,
-0.0023136062,
0.0013578018,
0.00534979,
-0.010448544,
0.024750838,
0.016676962,
-0.015537121,
0.003061627,
0.018603837,
0.002152468,
-0.009803991,
0.015130035,
0.0040064063,
0.010970972,
0.0085013155,
0.0044406313,
-0.005234449,
-0.00089558953,
0.012735011,
-0.021561995,
0.0020032031,
0.0056245737,
-0.03609497,
-0.017138327,
-0.013868067,
0.017938929,
-0.00836562,
0.008779491,
0.00425405,
0.015225022,
-0.050125875,
-0.011561247,
0.026487738,
0.018834518,
-0.019526565,
-0.010658872,
0.040382944,
0.010808137,
0.003609497,
0.04814472,
-0.016595544,
-0.0013103085,
-0.019323023,
0.021955512,
-0.009912548,
0.019743677,
-0.00596042,
-0.017694678,
0.021629844,
0.0012178661,
0.006822085,
0.008908401,
0.0021117593,
0.017830374,
0.0022712015,
-0.02526648,
0.023027506,
0.007687143,
0.02230832,
0.023298897,
0.014030903,
-0.017721817,
-0.053572536,
0.018929506,
-0.01792536,
-0.027451176,
0.015754234,
0.00088371616,
-0.020096486,
-0.009905763,
0.004589896,
0.004773085,
-0.014722949,
-0.0066728205,
-0.008372405,
-0.03414096,
-0.0020099878,
0.01556426,
-0.013128528,
-0.011798713,
-0.04293402,
0.08196001,
-0.0051666014,
0.023421023,
-0.007727852,
0.010536746,
-0.014207306,
0.015767803,
-0.01731473,
0.013963055,
0.011065958,
-0.036230665,
-0.00048299076,
-0.007076514,
-0.016324155,
0.013006402,
0.020761393,
-0.01678552,
0.010631733,
-0.010278925,
-0.013854498,
-0.01582208,
0.006479454,
0.008480961,
-0.021616274,
0.023624565,
-0.023665274,
-0.018020347,
-0.0013204857,
-0.013155667,
-0.02232189,
-0.011032035,
-0.0028105907,
0.005814547,
-0.00057628134,
0.0041081775,
0.010434975,
0.0117105115,
-0.010848845,
0.02906595,
-0.009478322,
-0.0007378436,
-0.0016580279,
0.02876742,
-0.013834144,
-0.014451558,
0.0055635106,
0.0024204664,
-0.011866561,
-0.0147093795,
-0.029690148,
-0.020679977,
-0.019024493,
0.0021914805,
0.02553787,
-0.00806709,
0.0050207293,
-0.037533343,
0.024099499,
0.010190723,
-0.033218227,
0.00130522,
0.015767803,
-0.015727095,
0.0060316594,
0.0064523155,
-0.17119329,
0.009837915,
0.027749706,
-0.013243869,
0.022498295,
0.007375044,
-0.0021372023,
-0.015170744,
-0.00084555184,
0.0031091203,
0.011601955,
-0.00704259,
-0.014546544,
-0.01583565,
0.016052764,
0.02232189,
-0.0048036166,
0.04515942,
0.019662261,
0.012307571,
0.025578579,
-0.006628719,
-0.00078279275,
-0.031617023,
0.0028156792,
0.0066355043,
0.0050207293,
-0.0036841296,
-0.014220876,
-0.010835276,
-0.00809423,
0.019757247,
0.028360335,
0.019730108,
0.02697624,
-0.0011847903,
-0.011914054,
0.009356196,
-0.009912548,
0.0041862023,
0.039623052,
0.03286542,
-0.012640025,
-0.011703727,
-0.014180168,
0.0108692,
0.023705984,
0.0072461334,
0.023217479,
-0.004349037,
0.018576698,
0.0033024864,
0.008060305,
0.024696559,
0.024615142,
0.011045604,
0.030748572,
0.015862789,
0.010224647,
0.0004622124,
-0.014071611,
-0.004382961,
0.010075382,
-0.009946471,
0.015442134,
-0.02377383,
-0.015157174,
0.01378665,
-0.013264223,
0.005865433,
-0.03023293,
0.0016478507,
0.016636254,
-0.009797206,
0.028278917,
0.0061978865,
-0.004562757,
0.014044472,
0.003785901,
0.02175197,
-0.0060214824,
-0.0031125129,
-0.0067270985,
-0.009044097,
0.009152654,
0.03196983,
0.013630601,
0.021317745,
-0.025958527,
0.0090915905,
0.029473037,
-0.014315862,
0.016351294,
-0.042744044,
0.04043722,
0.027234063,
-0.006557479,
-0.016541267,
0.0066558584,
-0.018861657,
0.027206924,
-0.02906595,
-0.02025932,
0.019485857,
0.029038811,
-0.00037295028,
-0.024031652,
0.0005724649,
0.038890295,
-0.027736135,
-0.010034673,
-0.0052378415,
0.0049189576,
0.02435732,
0.004311721,
0.021779109,
0.02822464,
-0.013067465,
-0.0060011283,
-0.03112852,
0.06453672,
0.009491892,
0.028875977,
0.03313681,
-0.00809423,
-0.01849528,
-0.129182,
-0.032214083,
0.0005576232,
0.015591399,
-0.02021861,
0.0220505,
0.002920843,
-0.00042595627,
-0.005611004,
0.023421023,
-0.0032719548,
0.0037689393,
-0.008338481,
0.005990951,
0.0059197107,
-0.01071315,
0.0288217,
0.014166597,
-0.024303043,
0.038320374,
-0.005098754,
-0.013630601,
-0.020395016,
-0.015211452,
0.017409718,
0.020381447,
-0.000027457112,
0.0064285686,
0.0010838668,
0.011276286,
0.0003818553,
0.0075107394,
0.03430379,
0.021046354,
-0.017491134,
-0.023081783,
-0.0037723316,
-0.013773081,
0.025076507,
-0.011968332,
0.004359214,
0.0010702973,
-0.012945339,
-0.0054922705,
-0.0027071228,
-0.009362982,
-0.03582358,
-0.0058518634,
0.02584997,
-0.015903499,
-0.026324904,
-0.014275154,
-0.0058891797,
-0.019485857,
0.026596295,
-0.02438446,
-0.0020065955,
0.02260685,
-0.02028646,
-0.017789664,
-0.018875228,
0.0032872206,
-0.0064523155,
-0.0025001874,
0.0004931679,
-0.010224647,
-0.0038300022,
-0.02912023,
0.018074624,
-0.010462114,
0.001931963,
0.012402558,
-0.012599316,
-0.009139084,
-0.013508475,
-0.00839276,
-0.023638135,
-0.03169844,
-0.008039951,
-0.03555219,
-0.01643271,
-0.030504322,
0.009139084,
-0.016934784,
0.013779866,
-0.012938554,
0.028713142,
0.011859776,
0.010190723,
0.000002451528,
-0.004413492,
0.03994872,
0.011520538,
-0.023163201,
-0.007252918,
-0.0006831414,
0.0069035026,
-0.012076889,
0.015469274,
0.04233696,
-0.039568774,
-0.014614392,
-0.06735919,
0.014627962,
0.010489253,
0.004057292,
0.0016122308,
-0.016609114,
0.015414995,
0.008582733,
0.005115716,
-0.012504329,
-0.0346566,
0.01678552,
-0.0021032784,
0.000100340374,
-0.013433843,
-0.017382579,
0.035579327,
0.0073886137,
0.02081567,
0.03196983,
-0.0011194869,
0.010624948,
0.018169612,
-0.020435724,
-0.0237874,
0.0016368255,
-0.031019963,
0.009485107,
-0.011656233,
-0.007286842,
-0.00823671,
-0.015225022,
-0.0335439,
-0.010339988,
-0.030640017,
-0.0072122095,
-0.02025932,
0.01583565,
0.009512247,
0.012416127,
0.012273647,
-0.0077617755,
-0.00044949094,
-0.0042031645,
0.015252161,
-0.0105571,
-0.0100414585,
0.0030141335,
0.0032838283,
0.010095736,
0.017653968,
0.025185062,
-0.011886915,
-0.03788615,
-0.013990194,
-0.010903124,
0.003775724,
-0.022620419,
-0.028441751,
-0.044562362,
0.019770816,
0.025931386,
-0.0055024475,
-0.0071172225,
-0.0010957402,
-0.015374286,
-0.016609114,
-0.0055736876,
0.013847713,
-0.029771566,
-0.037180535,
0.010645303,
0.01588993,
-0.0021779109,
0.01203618,
0.008277418,
-0.036936283,
-0.010896339,
0.019133048,
0.024153778,
0.025985666,
-0.0064896317,
-0.03026007,
0.013019972,
0.012253293,
0.0048918184,
-0.0024764407,
0.005726345,
0.011249147,
0.015184313,
0.0017038251,
0.014180168,
-0.0035416493,
-0.003979267,
-0.0047255917,
-0.002532415,
0.022688268,
0.012300787,
-0.00063055946,
0.027179785,
0.013182806,
-0.010217862,
0.0018810772,
-0.0017877866,
-0.027519023,
0.00499359,
-0.015591399,
-0.024886534,
-0.015509982,
0.008216355,
0.014831505,
0.008955895,
0.0035416493,
-0.0062250257,
0.0050173365,
0.009057666,
0.0057365224,
0.0100414585,
-0.00822314,
0.026365612,
0.015686385,
0.00910516,
0.016663393,
0.0006504897,
0.0020947973,
0.008046736,
0.041984152,
-0.03194269,
0.042201262,
-0.0063844677,
0.022864671,
-0.008019597,
-0.039813023,
-0.023692414,
-0.015862789,
-0.011350919,
0.012226154,
0.010875985,
-0.019621551,
0.10003463,
0.011771575,
-0.028577447,
-0.0077956994,
-0.009858269,
0.024262333,
0.025524301,
0.00009238947,
-0.03549791,
-0.019458717,
0.0288217,
-0.038917433,
0.016934784,
-0.03082999,
-0.023434592,
0.03267545,
-0.009098375,
0.01409875,
-0.0075107394,
-0.020110056,
0.033218227,
-0.01556426,
-0.009356196,
0.011255932,
-0.050614376,
-0.014220876,
0.023814538,
0.013060681,
0.01940444,
-0.046516377,
0.0016707494,
-0.0037960783,
-0.015062187,
0.0030158297,
0.030775713,
-0.029798705,
-0.0048850337,
-0.025022227,
0.028278917,
0.025470022,
-0.0058552558,
0.037424784,
-0.020177903,
-0.02199622,
0.028061805,
0.004148886,
-0.012144737,
-0.00601809,
-0.01822389
] |
Polyhomeotic-like 3 (PHC3) is a ubiquitously expressed member of the polycomb gene family and part of the human polycomb complex hPRC-H. We found that in normal cells PHC3 associated with both hPRC-H complex components and with the transcription factor E2F6. In differentiating and confluent cells, PHC3 and E2F6 showed nuclear colocalization in a punctate pattern that resembled the binding of polycomb bodies to heterochromatin. This punctate pattern was not seen in proliferating cells suggesting that PHC3 may be part of an E2 | [
-0.023674741,
-0.0032554443,
-0.008953308,
-0.013443345,
-0.0071465867,
0.013496878,
-0.007822434,
0.012774189,
-0.014012128,
0.006835429,
0.025093352,
-0.009595698,
0.01148941,
0.005697864,
-0.013041852,
0.006172965,
0.020342344,
-0.02863988,
-0.012499835,
0.021707423,
-0.02671271,
0.018722987,
-0.0168895,
-0.032440685,
-0.01076003,
0.01779955,
0.019271694,
-0.023607826,
0.0032554443,
-0.015872382,
0.017518505,
-0.00810348,
0.021359462,
-0.0020543092,
-0.026003405,
-0.0074410154,
0.010044033,
-0.00017774459,
0.017612187,
0.01787985,
0.032654814,
0.022403345,
-0.0026147272,
0.008183778,
-0.01333628,
-0.008565198,
0.016876116,
-0.014895414,
-0.024946138,
0.02443758,
0.00981652,
0.02482569,
-0.008411292,
-0.00009294996,
-0.014293173,
0.0029375951,
0.022162449,
0.025869574,
-0.010686423,
0.01050575,
-0.00035548917,
-0.0147482,
-0.025320865,
0.010592741,
0.01431994,
0.00947525,
-0.010739955,
-0.0067818966,
0.018107364,
-0.0072268853,
0.039721105,
0.016862733,
-0.009294578,
-0.01787985,
0.0210115,
-0.016220342,
-0.011442569,
0.007922808,
0.0017648991,
-0.00926112,
-0.0014119192,
-0.0252138,
-0.015203225,
0.0051826136,
0.01916463,
-0.010806871,
0.008759253,
0.009281195,
0.022885138,
0.00021297982,
0.019244928,
0.029121673,
0.019231545,
0.020034533,
-0.014774966,
0.0023437191,
0.00029003734,
0.030352918,
0.013864914,
-0.005289679,
-0.032842178,
0.021038266,
-0.030700881,
-0.012125108,
-0.032306854,
-0.014908797,
0.019459058,
-0.0052629123,
0.015363824,
0.0022349812,
-0.014547453,
0.036883883,
0.006363674,
-0.028827243,
0.020047916,
-0.032949246,
0.0006461538,
0.0077755935,
-0.01389168,
-0.017157162,
0.009073757,
0.044565793,
-0.012459686,
-0.023674741,
0.025106736,
0.0027619416,
-0.016300641,
-0.0028138012,
-0.0064874683,
-0.007126512,
0.021573592,
-0.006139507,
0.0011785511,
0.0015942643,
-0.034287557,
-0.009113906,
-0.029228738,
-0.024223449,
-0.011335503,
-0.029148439,
0.017304376,
0.017331142,
-0.00505882,
-0.004249141,
0.010365227,
0.021332696,
-0.0005692009,
0.0067082895,
-0.006758476,
0.020154981,
0.026097087,
0.026525347,
0.018709604,
0.01929846,
0.01749174,
0.023768423,
-0.0068655415,
0.02301897,
-0.008491591,
-0.023273248,
-0.031075608,
0.0020325615,
0.0018903658,
0.015377207,
0.020141598,
0.023621209,
0.005908648,
-0.009662613,
-0.0029610156,
0.0012856161,
-0.019940851,
0.013597251,
-0.039453443,
-0.00022521283,
-0.013282748,
-0.01638094,
-0.0071800444,
0.014092427,
-0.024665093,
-0.026030172,
-0.007722061,
0.008056639,
0.02152006,
0.0004922479,
-0.022671007,
-0.014413621,
0.008826168,
-0.023259865,
-0.0094351005,
-0.008197161,
0.0041052722,
0.0011091261,
0.02208215,
-0.017398058,
-0.6291138,
-0.002619746,
-0.008076713,
-0.020931201,
0.0126470495,
0.020569857,
0.020168364,
-0.017424824,
-0.03126297,
-0.007052905,
-0.01612666,
0.024250217,
0.010726572,
-0.0072268853,
-0.022657624,
-0.04039026,
0.0041521136,
-0.034635518,
0.032012425,
-0.0011869156,
-0.026980372,
-0.008879701,
-0.019030798,
0.017464973,
-0.0018987303,
0.013918446,
0.034287557,
-0.001576699,
0.0028522778,
0.00499525,
-0.009328036,
0.020610007,
-0.009890127,
-0.02190817,
0.05406781,
0.011823988,
0.0049015684,
0.020141598,
0.027462166,
0.0272748,
-0.00463056,
0.010739955,
0.018856818,
0.003290575,
-0.03056705,
0.013015086,
0.0025528304,
0.008471516,
0.008605347,
-0.011583092,
-0.007434324,
-0.012640358,
-0.0039045257,
0.00405174,
0.008324302,
0.006714981,
0.02486584,
-0.012084958,
0.004132039,
-0.018495474,
0.014119193,
0.009876744,
-0.017826317,
-0.012165258,
-0.000016598207,
0.0067718592,
-0.007822434,
-0.01573855,
-0.0000010520911,
0.010398685,
-0.014774966,
0.027863659,
-0.0048313066,
0.0031500522,
-0.0041688425,
0.029817594,
0.012285706,
-0.004633906,
-0.00040170274,
0.025695592,
0.0015022553,
-0.006838775,
-0.019231545,
-0.002984436,
0.017050097,
-0.008110171,
-0.040015534,
0.03656269,
-0.006791934,
-0.0033708736,
0.0115563255,
0.0053532487,
0.004797849,
-0.007153278,
-0.015270142,
-0.009622464,
-0.008290844,
0.009381568,
-0.0034394623,
-0.025106736,
-0.0129013285,
-0.052328005,
-0.011897595,
-0.0060491706,
0.005085586,
0.011844062,
-0.018267961,
0.009829903,
0.03634856,
-0.02097135,
-0.0064473185,
0.0008544286,
0.0018602539,
0.005881882,
0.0010438835,
-0.026311217,
0.01148941,
0.02023528,
-0.01838841,
-0.014052277,
0.026016789,
-0.001933861,
-0.010438834,
-0.014855265,
0.03056705,
0.018468708,
0.017652337,
-0.007019447,
0.0007774757,
0.003747274,
0.032842178,
0.0011384018,
0.027622763,
-0.029576698,
0.041701805,
0.0044498877,
0.021172099,
-0.00014052277,
0.027676295,
-0.01834826,
-0.003442808,
-0.0039379834,
0.0028422405,
0.0037974606,
0.01762557,
-0.026685944,
-0.025347631,
-0.010880478,
0.013644092,
-0.004262524,
0.014333323,
-0.008264078,
-0.011288662,
-0.0032654817,
0.00057212845,
-0.0072201937,
-0.00405174,
-0.020221896,
-0.019178012,
-0.03327044,
0.008973382,
0.005175922,
-0.011288662,
0.0070729796,
0.003747274,
-0.0016436146,
-0.017224077,
0.01702333,
-0.0072268853,
-0.011636624,
-0.003897834,
-0.0200613,
-0.020355728,
0.004403047,
-0.005390052,
0.032601282,
0.014413621,
-0.012713965,
-0.015203225,
-0.011944436,
-0.0033842567,
-0.008029873,
-0.013429962,
-0.014373472,
0.03262805,
-0.008123554,
0.057386823,
0.0055238833,
0.020877669,
0.02358106,
0.00055247196,
0.004754354,
-0.006524272,
0.032173023,
-0.006564421,
-0.02354091,
0.019097714,
0.016247109,
0.009508708,
0.04282599,
0.016153427,
-0.0034394623,
-0.0084046,
-0.0263246,
0.02126578,
-0.050695263,
-0.004282599,
-0.010679731,
-0.010532516,
0.0045301868,
-0.008250695,
-0.011884212,
-0.020262046,
0.01106115,
-0.0006591187,
0.020663539,
-0.031396803,
-0.0042892904,
-0.007494548,
-0.010920627,
0.016233725,
-0.0153504405,
0.01307531,
0.0016996564,
0.0016770724,
-0.017919999,
0.00891985,
0.015858999,
0.012653741,
0.0021814487,
-0.01869622,
0.011957819,
-0.007909425,
0.02332678,
-0.00368705,
0.029978191,
0.031075608,
-0.012158566,
0.033966362,
0.003640209,
-0.00621646,
0.021854637,
-0.004356206,
0.001462106,
-0.018843435,
-0.02147991,
0.02143976,
-0.013864914,
0.0021061688,
0.028051022,
-0.009682688,
0.005587453,
-0.011449261,
0.00037347272,
0.03005849,
-0.010492367,
-0.017786168,
0.00908714,
0.049972575,
0.022965437,
-0.008384526,
-0.030031724,
-0.002255056,
0.006092666,
-0.0037874233,
-0.0039547123,
-0.0019188051,
-0.018937116,
-0.011723614,
-0.007186736,
-0.026685944,
0.021399612,
0.0037807317,
-0.037017714,
0.0009995518,
0.0061060493,
0.006333562,
0.004356206,
0.010278237,
-0.004172188,
-0.012486452,
-0.033083078,
0.0052428376,
0.04159474,
-0.019017415,
-0.00052946975,
-0.030888245,
0.0019020761,
0.007635071,
0.014734817,
0.0016168484,
0.015069394,
0.021533443,
-0.009836595,
-0.0058417325,
-0.001242121,
-0.001979029,
0.0050086332,
0.01136227,
-0.007173353,
-0.01294817,
-0.0033223599,
-0.02486584,
-0.0032587901,
0.033511337,
0.0067250184,
-0.0028104554,
-0.0072268853,
-0.010084182,
-0.010010575,
0.009923585,
-0.022697775,
-0.0010305004,
-0.004540224,
-0.010699806,
-0.0012931441,
-0.005102315,
0.017853083,
0.023500761,
-0.0073941746,
-0.00861873,
-0.015711784,
-0.005620911,
0.0026080357,
0.027890425,
0.022818223,
0.010820254,
0.026337983,
-0.0017163854,
0.011904286,
-0.020944584,
-0.007474473,
0.015403973,
0.00022395817,
-0.013617326,
0.00055581774,
0.013476803,
0.0012237192,
-0.0055038086,
0.014079044,
-0.0019104406,
-0.014400238,
-0.007849201,
0.014079044,
0.0061027035,
-0.007233577,
0.03867722,
0.04060439,
0.028961075,
-0.004188917,
0.020101449,
0.030459983,
0.010398685,
-0.003181837,
-0.007568155,
0.0029743987,
0.0073941746,
0.001202808,
-0.009113906,
-0.029362569,
-0.0066949064,
0.009856669,
0.0029928004,
-0.001110799,
0.015658252,
0.023768423,
0.0030898282,
-0.02173419,
-0.0070261387,
0.01813413,
-0.008290844,
0.0180003,
-0.017598804,
-0.003166781,
0.023982553,
-0.027756594,
-0.0134834945,
-0.004232412,
-0.0025846153,
-0.019740105,
-0.006805317,
-0.023594443,
0.007996415,
-0.031236205,
-0.011589783,
-0.018321494,
-0.0065309634,
-0.00694584,
-0.0047744284,
-0.02319295,
0.009354802,
-0.036295027,
-0.017759401,
-0.0103317695,
-0.0027987452,
-0.020783987,
-0.028613113,
-0.0056945183,
0.006183002,
0.020248663,
0.028265152,
-0.0040550856,
0.0046974756,
0.015845615,
0.0007674384,
-0.029175205,
-0.0018217774,
-0.025668826,
-0.002418999,
-0.011522868,
-0.009936968,
-0.0052762954,
-0.026940223,
0.0124529945,
-0.0018502165,
-0.026030172,
0.019887319,
-0.0026548768,
-0.013102076,
0.009910202,
0.022711158,
0.022751307,
0.006778551,
0.0069056908,
-0.014815115,
-0.04060439,
-0.007648454,
-0.030352918,
0.009783062,
0.0039379834,
0.00053867063,
0.0025963255,
-0.026391516,
-0.016260492,
0.019646423,
-0.023821956,
-0.000982823,
0.011161523,
0.021894787,
0.025187034,
-0.012439611,
-0.0024407466,
0.00059262133,
-0.03219979,
0.009154055,
-0.0052562207,
0.019191395,
-0.020275429,
-0.039078712,
0.008598655,
-0.005804929,
-0.01595268,
-0.0017347871,
0.012205407,
-0.008953308,
0.044110768,
-0.00047384613,
0.024036085,
-0.011335503,
-0.0047878115,
-0.023607826,
0.00006665422,
0.0028840627,
-0.017732635,
-0.0016871097,
-0.0014897087,
0.0062231515,
-0.015858999,
-0.018749753,
-0.029094907,
-0.004158805,
0.011884212,
0.0077287527,
0.030433217,
0.016621837,
-0.0023788498,
-0.004841344,
-0.017357908,
-0.025133502,
-0.033163376,
0.008993457,
-0.0105258245,
0.031610932,
0.03589353,
0.032654814,
-0.0013031814,
0.0067551304,
0.037312143,
0.01719731,
-0.000027184466,
-0.018843435,
0.007755519,
-0.01671552,
0.03254775,
-0.0053733233,
0.019271694,
0.024638327,
0.009341419,
0.0272748,
0.046573263,
-0.015939297,
-0.024531262,
0.017371291,
-0.02688669,
-0.053264823,
0.012908021,
-0.0115563255,
-0.001058103,
-0.017157162,
-0.010097565,
-0.009675996,
0.028720178,
-0.0039379834,
-0.0013901717,
0.015751934,
-0.014212875,
0.041915935,
-0.026030172,
0.012546676,
-0.01234593,
0.0015407319,
0.0070462134,
0.0018418521,
0.01852224,
0.01984717,
0.02984436,
-0.010552591,
-0.0105258245,
0.0012203733,
0.018334877,
-0.019566124,
-0.024317132,
-0.00076492905,
-0.015551187,
-0.006959223,
-0.019418908,
0.002924212,
-0.04124678,
-0.013222524,
0.005055474,
-0.022523792,
0.012546676,
0.024290366,
-0.024156533,
0.018027065,
-0.0017314414,
0.030888245,
-0.023072502,
0.01838841,
0.023594443,
-0.0067685135,
-0.011857445,
-0.015029245,
-0.019699955,
0.010318386,
0.03490318,
0.036375325,
-0.012178641,
0.0021981776,
-0.0032387155,
0.011917669,
-0.019753488,
-0.05093616,
0.0009669305,
0.0084046,
0.019900702,
0.0031902015,
0.018254578,
-0.0049015684,
-0.013824765,
0.007300493,
0.02482569,
-0.0044097384,
-0.006172965,
-0.019311843,
0.020302195,
-0.015551187,
-0.004854727,
0.01706348,
-0.007039522,
-0.00061478716,
-0.03426079,
0.013215832,
0.014092427,
-0.012533293,
0.02447773,
-0.004777774,
-0.004031665,
0.023848722,
0.0017833009,
-0.011977893,
0.0050487826,
-0.016742285,
0.035224374,
-0.033511337,
0.002618073,
0.014681284,
-0.0001937416,
0.022751307,
-0.0036636295,
-0.0038944883,
-0.02143976,
-0.015765317,
0.004784466,
0.026297834,
-0.0008406273,
0.0027335025,
-0.010880478,
-0.016541539,
0.0074677817,
-0.028479282,
-0.040631156,
0.0064540105,
-0.04282599,
-0.0017582076,
0.006316833,
0.013470111,
0.0356794,
0.015457505,
-0.0004157132,
-0.023045735,
0.026431665,
0.0060859746,
0.012352621,
-0.0033876025,
0.004587065,
-0.025534995,
0.0087324865,
-0.012861179,
-0.027622763,
-0.0031182673,
-0.030433217,
-0.019057564,
-0.0008000597,
-0.009843286,
0.024959521,
0.018107364,
-0.013590559,
0.023139417,
0.0043930095,
0.03276188,
-0.015832232,
0.0031349962,
0.018241195,
-0.016046362,
0.014627752,
0.008959999,
0.013115459,
0.0044933828,
-0.012727348,
-0.034715816,
0.007949574,
-0.025053203,
-0.008839551,
-0.019499207,
-0.007909425,
0.009334727,
-0.005236146,
-0.01650139,
-0.005911994,
-0.01209165,
0.006112741,
-0.0048179235,
0.007173353,
-0.017398058,
0.021854637,
0.001227065,
0.010766721,
-0.028104555,
-0.010867095,
-0.008036564,
-0.03300278,
-0.033243675,
0.003626826,
-0.02611047,
0.046198536,
0.0040082447,
-0.033511337,
-0.009936968,
-0.017946765,
-0.040069066,
-0.04052409,
-0.007079671,
0.0012697236,
-0.015256759,
0.0037706944,
-0.014627752,
0.0010112621,
0.0040985807,
0.003014548,
-0.0052461834,
-0.016260492,
0.0012764152,
-0.017344525,
0.0035967138,
0.008765944,
-0.024732009,
-0.008712412,
0.023460612,
-0.0010622853,
-0.013429962,
0.04111295,
-0.027488932,
0.023661358,
-0.019325227,
0.0111079905,
-0.0004989395,
0.012513218,
0.0079562655,
-0.022684392,
0.0030680806,
0.0038944883,
0.0059487973,
-0.023233099,
0.0060659,
-0.00202587,
-0.017384674,
0.004884839,
-0.008786019,
-0.032788645,
0.008953308,
-0.014400238,
0.014895414,
0.00891985,
0.00079922326,
0.00831761,
0.023514144,
0.0039045257,
-0.024732009,
-0.011208364,
-0.027462166,
0.009749603,
0.013771232,
-0.0034126958,
-0.0015800447,
-0.025722358,
-0.019044181,
-0.01908433,
-0.021506676,
-0.0009025242,
-0.018080598,
-0.024062851,
0.032280087,
-0.0074543986,
-0.018080598,
-0.007842509,
-0.010519133,
-0.0027652874,
-0.01684935,
0.018642688,
-0.0011442569,
-0.03048675,
0.015337057,
-0.013175683,
-0.012767497,
0.0017381329,
-0.0009761314,
-0.0073540253,
0.01243292,
0.027703062,
0.20192453,
-0.0028673338,
-0.008946616,
0.009896819,
0.027890425,
-0.010385302,
0.010539208,
0.012754114,
-0.0049617924,
0.0008866318,
-0.0020275428,
-0.011890903,
-0.008966691,
0.011067841,
0.024424197,
-0.02546808,
-0.01581885,
-0.010947393,
-0.045342013,
-0.01041876,
0.00303295,
-0.023607826,
0.020810753,
-0.020850902,
0.022389961,
-0.0023504107,
-0.022095533,
0.00035569828,
-0.0017448245,
0.0091205975,
-0.031102374,
-0.008939925,
-0.015270142,
-0.0060893204,
-0.00658115,
0.0066748317,
-0.009595698,
0.0072938013,
-0.012111724,
0.01779955,
-0.005727976,
0.006872233,
0.012807647,
-0.003700433,
0.01067304,
-0.017371291,
0.0047744284,
0.005410127,
0.0013692606,
-0.0003749365,
-0.057012096,
0.016621837,
0.020569857,
0.0419427,
-0.015832232,
0.009856669,
0.009408334,
0.015270142,
-0.023567677,
0.037312143,
0.006554384,
0.015591336,
-0.016032979,
-0.01710363,
-0.020944584,
0.023808572,
0.006377057,
0.0117503805,
0.018508857,
-0.03399313,
0.02671271,
0.0059186853,
-0.0231528,
-0.0029877818,
-0.007755519,
-0.014895414,
0.04047056,
0.010144406,
0.034019895,
0.019967617,
0.010880478,
-0.022108916,
-0.020034533,
0.0038443017,
-0.008933233,
-0.034367856,
0.04269216,
0.0099905,
-0.019606274,
-0.036669753,
0.026471814,
-0.0070328303,
-0.0034863031,
-0.002681643,
0.009301269,
0.006919074,
-0.009421717,
0.017157162,
-0.0046104854,
-0.0018786556,
-0.02058324,
0.06359659,
0.016220342,
0.010084182,
-0.0168895,
0.015256759,
0.00023650484,
-0.012834413,
0.007922808,
-0.014681284,
0.021881403,
-0.021412995,
0.011355579,
-0.008511665,
0.029790828,
0.0029928004,
0.012954862,
-0.04617177,
0.027863659,
-0.007267035,
0.007113129,
-0.019820403,
-0.0020710381,
0.049758445,
-0.004252487,
-0.0019840477,
-0.0063101416,
-0.0019388797,
-0.0094351005,
-0.022617474,
0.017331142,
0.012954862,
0.021573592,
0.004188917,
0.0034929947,
-0.01573855,
0.00505882,
-0.0023102614,
-0.017398058,
0.040309962,
-0.021051649,
-0.013784615,
0.017906616,
-0.0008423002,
-0.0054770424,
-0.014560836,
0.02002115,
0.01766572,
-0.019258311,
-0.027703062,
-0.008551815,
-0.004356206,
-0.027943958,
-0.020088065,
0.019900702,
-0.042290665,
-0.014253024,
-0.017036714,
0.009401643,
0.013269365,
-0.013155608,
0.01050575,
0.021372845,
0.0016001194,
-0.012633666,
0.004232412,
-0.16894853,
0.004429813,
0.0105258245,
-0.013450037,
0.012794264,
0.02301897,
0.009796445,
-0.021801105,
-0.016983181,
0.0031617624,
0.0047142045,
0.012078267,
-0.03276188,
-0.04660003,
0.010646273,
0.021560209,
-0.0032420612,
0.0485272,
0.017732635,
0.008799402,
0.022215981,
-0.016394323,
0.023634592,
-0.012258939,
0.0069391485,
0.006992681,
0.0040115905,
-0.017371291,
-0.013309514,
-0.0059019565,
0.00047259146,
-0.000087042565,
0.026793009,
0.01431994,
-0.0019773562,
-0.012225482,
-0.0012814339,
0.0091808215,
0.014373472,
0.010010575,
0.03056705,
0.020047916,
0.010164481,
0.00062440627,
-0.015872382,
0.028934307,
-0.0082105445,
0.0007277072,
0.022242747,
0.0012772516,
0.027676295,
0.00030383866,
0.036750052,
0.002285168,
0.030112023,
-0.0068923077,
0.0128411045,
0.015283525,
-0.0017096937,
-0.0064975056,
-0.020382494,
-0.035438504,
0.024169916,
-0.013322897,
0.011114682,
-0.01616681,
-0.006979298,
0.013296131,
-0.022550559,
0.019753488,
-0.004924989,
-0.00602575,
0.013905063,
-0.027542464,
0.021158716,
0.013704317,
-0.009247737,
0.02247026,
0.0054469304,
0.010900552,
-0.0069123823,
-0.0024089618,
-0.012861179,
-0.026164003,
-0.00072603434,
0.0018853472,
-0.011977893,
0.018923733,
-0.022202598,
0.0036335175,
0.017772784,
-0.03546527,
0.0065711127,
0.0013466766,
0.047322717,
0.0153504405,
-0.00981652,
-0.022068767,
-0.0168895,
-0.01848209,
0.023473995,
-0.00883286,
-0.01234593,
0.019713338,
0.04047056,
0.012171949,
-0.029442867,
0.006832083,
0.062311813,
-0.014226258,
0.010559283,
-0.0044666165,
0.019726722,
0.026953606,
0.0066614486,
0.011870828,
-0.006992681,
0.008799402,
0.014119193,
-0.021412995,
0.057440355,
0.0058718445,
-0.0060190586,
0.0054937713,
-0.0072201937,
-0.0074811648,
-0.12462363,
0.006898999,
0.012018043,
0.02799749,
-0.0056242566,
0.016769052,
-0.00091339805,
0.007267035,
-0.013797998,
0.04052409,
-0.0013818073,
-0.011221747,
0.01539059,
0.0038911426,
0.0023654667,
0.0137177,
0.0075146225,
-0.010124331,
0.011482718,
0.031450335,
-0.014119193,
0.005684481,
0.0064841225,
-0.031236205,
0.03519761,
0.007213502,
-0.028184853,
0.0019740104,
0.0056142192,
0.00478112,
-0.024116384,
-0.0180003,
0.02075722,
0.0046974756,
-0.027154353,
-0.013363047,
0.009361493,
-0.0030429873,
0.041005883,
-0.022416728,
0.001462106,
-0.02002115,
-0.02340708,
0.0016829275,
0.019619657,
-0.0066781775,
-0.0025628677,
0.0098232115,
0.030674115,
0.0043294397,
-0.039962,
-0.02615062,
-0.029335802,
-0.010806871,
0.015189842,
-0.019378759,
0.018615922,
0.028961075,
-0.016434474,
0.014641135,
-0.01741144,
0.008344376,
-0.009582315,
0.014882031,
0.019244928,
-0.0056677517,
-0.011389037,
-0.029389335,
0.036723286,
-0.027047288,
-0.029094907,
0.005497117,
-0.02379519,
0.015229992,
-0.005671098,
0.00715997,
-0.012653741,
-0.02499967,
0.012299089,
-0.017652337,
-0.000101994025,
-0.018549006,
0.027863659,
-0.013664166,
0.0031768184,
0.0036669753,
0.030299386,
-0.012640358,
0.0047309333,
-0.016862733,
-0.0024390738,
0.027408633,
0.007681912,
-0.030620582,
-0.035625868,
-0.0026849888,
-0.0025628677,
-0.0054302015,
0.008558506,
0.041327078,
-0.027207885,
-0.024852457,
-0.07532021,
0.009615772,
-0.01838841,
-0.013055235,
0.017518505,
-0.03546527,
0.01581885,
-0.0016277222,
-0.021172099,
-0.002010814,
-0.012800955,
0.017505122,
-0.029309036,
-0.01710363,
-0.017224077,
0.01684935,
0.026833158,
-0.007240269,
0.022671007,
0.014360089,
0.0031717997,
-0.014694667,
0.013269365,
-0.0031099028,
-0.03589353,
-0.02208215,
-0.014132576,
0.018361643,
-0.023059119,
0.024357282,
0.0013349664,
-0.040443793,
-0.03335074,
0.010820254,
-0.0036435549,
-0.021787722,
-0.015470888,
0.024584794,
0.0050019417,
0.0072938013,
-0.026873307,
-0.045475848,
0.0029476325,
0.001294817,
0.012319163,
0.0069993725,
-0.028452516,
0.0030513518,
0.014882031,
0.019860553,
0.026083704,
0.01234593,
0.0025762508,
-0.011890903,
-0.010311695,
-0.0027887078,
-0.026230918,
0.0066447197,
0.022791456,
-0.03169123,
-0.005149156,
0.027836893,
0.02706067,
0.018843435,
0.005543958,
0.0050353995,
-0.011991276,
-0.013309514,
-0.0049149515,
-0.029576698,
-0.011803913,
0.00008834951,
0.0087324865,
0.012319163,
0.0027468856,
0.0028974458,
-0.016916266,
0.026993755,
-0.009548857,
0.03447492,
0.0076083043,
-0.0021714114,
0.0033574905,
0.004794503,
0.035010245,
-0.0147482,
-0.012466378,
0.0144403875,
-0.0014913816,
0.020114832,
0.010184555,
0.019954234,
-0.001309873,
-0.0041052722,
-0.0001383271,
-0.0053231367,
-0.012667124,
-0.0033240328,
-0.0067116353,
0.033163376,
-0.009977117,
0.009455175,
0.003305631,
-0.021680657,
-0.02272454,
0.005088932,
-0.020489559,
-0.0316377,
-0.002863988,
0.0011442569,
0.01427979,
0.0021279163,
0.01333628,
-0.0016034652,
-0.017732635,
0.008585272,
-0.0073741,
-0.009341419,
-0.017545272,
0.039935235,
-0.004232412,
0.023768423,
0.0014754891,
0.0058250036,
0.043013353,
0.007829126,
0.02971053,
-0.02688669,
0.022617474,
-0.023393696,
0.021279164,
-0.013704317,
-0.042210363,
-0.015363824,
-0.010806871,
-0.004235758,
-0.007521314,
0.0127072735,
-0.004643943,
0.08629437,
-0.003429425,
-0.027154353,
-0.0012680507,
-0.013008394,
0.02589634,
0.011302046,
-0.004754354,
-0.01667537,
-0.012265631,
0.0054603135,
-0.03677682,
0.005015325,
-0.012573442,
-0.017143779,
0.016233725,
-0.014079044,
0.0038877968,
-0.003914563,
-0.0035833307,
0.015618103,
-0.015457505,
0.0012488125,
0.019793637,
-0.038918115,
-0.0007720388,
0.02319295,
-0.003275519,
-0.006788588,
-0.008598655,
0.014052277,
-0.017371291,
-0.034180492,
-0.0009067065,
0.018656071,
0.0032052575,
0.007200119,
-0.014587603,
0.036107663,
0.034501687,
0.0017933382,
-0.00030153844,
0.00051775953,
-0.004764391,
0.020556474,
-0.011823988,
0.015912531,
0.0003174309,
-0.022630857
] |
CD4 T cell help is critical for the generation and maintenance of germinal centers (GCs), and T follicular helper (T(FH)) cells are the CD4 T cell subset required for this process. Signaling lymphocytic activation molecule (SLAM)-associated protein (SAP [SH2D1A]) expression in CD4 T cells is essential for GC development. However, SAP-deficient mice have only a moderate defect in T(FH) differentiation, as defined by common T(FH) surface markers. CXCR5(+) T(FH) cells are found within the GC, as well as along the | [
-0.020529144,
0.019695608,
0.0034198433,
-0.024481708,
-0.016509356,
-0.0064464468,
-0.019897271,
0.006268312,
-0.015151503,
-0.015675822,
0.031378534,
-0.005273449,
-0.015837152,
0.00031362567,
-0.019130956,
0.008745388,
0.029066147,
-0.01111155,
-0.008019406,
-0.003713933,
-0.029066147,
0.004476886,
0.0032517922,
-0.020287149,
0.0013729789,
0.02019304,
0.008315177,
-0.048398767,
-0.023083523,
-0.0025442962,
-0.0039290385,
0.0073270355,
-0.02477748,
0.003562687,
0.01383398,
-0.029415695,
0.016697574,
-0.0125164585,
0.012563513,
0.00540789,
0.01796132,
0.011709812,
-0.00014084797,
0.004476886,
0.014358301,
0.005401168,
0.0017376501,
-0.0065607214,
-0.012005582,
0.017450444,
0.0051154806,
0.00422817,
-0.011434209,
-0.02065014,
-0.028635936,
-0.010042744,
0.0045810775,
0.006762383,
-0.004224809,
-0.026538657,
-0.018929295,
0.013760038,
-0.0028182198,
0.028340166,
0.002559421,
0.01540694,
-0.0015813624,
0.027493188,
0.015985036,
-0.009141989,
0.014358301,
0.016280808,
-0.0038013197,
0.015460717,
0.02169878,
0.0029056065,
-0.031055875,
0.0032921243,
-0.015433828,
0.0013780204,
0.01996449,
-0.035438653,
-0.010271293,
0.030007234,
0.00799924,
0.018929295,
0.008550448,
0.030867657,
0.015568269,
-0.0018502445,
0.022048326,
0.012220688,
0.021120684,
0.03845013,
0.007790857,
-0.009558756,
0.008530282,
0.022330653,
-0.004500413,
-0.02573201,
-0.030249229,
0.008899995,
-0.020959355,
-0.011192215,
-0.0325885,
-0.0076631377,
0.009713363,
0.000076305776,
0.013981866,
-0.01944017,
-0.027520075,
0.023984278,
-0.020905579,
-0.045333512,
0.009841083,
0.022007994,
0.013544932,
-0.020999687,
-0.011427486,
0.0073270355,
0.018337755,
-0.0043021124,
0.026726874,
-0.0075018085,
0.015985036,
0.019144401,
0.0072530927,
-0.004386138,
-0.02602778,
-0.022626422,
0.024965696,
0.00990158,
0.009034436,
0.017396668,
-0.007925298,
0.0026417659,
-0.016267363,
-0.009988967,
-0.015084282,
-0.020999687,
0.0051961453,
0.041569162,
0.0053574746,
0.012745008,
0.0067086066,
0.014546518,
0.023177631,
-0.01782688,
0.0035458817,
0.009720085,
-0.011044329,
-0.01327605,
0.0037609874,
-0.011958528,
0.025073249,
-0.0033358177,
-0.021873552,
0.046866138,
-0.009545312,
-0.02012582,
-0.01166948,
-0.01615981,
0.014385189,
-0.002582948,
0.006930434,
0.026095001,
0.007871522,
0.034497563,
0.012476127,
0.011326656,
0.021134127,
0.0064531686,
-0.009121823,
0.01750422,
-0.010681339,
0.020018267,
0.0037744315,
0.00048524805,
-0.0061607594,
-0.03635285,
-0.0035996581,
0.031324755,
0.010419179,
-0.012798784,
-0.02065014,
-0.004009703,
0.016616909,
-0.007421144,
-0.026673097,
-0.0149498405,
-0.017517664,
0.000019851057,
0.023016302,
-0.016872348,
-0.62122506,
-0.008758832,
0.017006788,
-0.010835946,
-0.0019023403,
0.029146813,
-0.013524766,
0.003445051,
-0.045817498,
0.020098932,
-0.017463887,
0.04009031,
0.0008352148,
-0.021120684,
0.0034114409,
-0.038342576,
-0.0010435984,
-0.0074076997,
-0.0061742035,
0.0019409922,
0.00047684548,
-0.014049086,
-0.008812608,
0.015702711,
0.0067892713,
-0.008241234,
0.046462815,
-0.013134887,
0.004265141,
0.03129787,
-0.023056634,
0.007185872,
-0.01533972,
-0.01586404,
0.049931392,
0.006113705,
-0.023419624,
0.02842083,
0.014748179,
0.04280602,
-0.025933672,
-0.0007843793,
-0.003693767,
0.0041340613,
-0.013464267,
0.008590781,
-0.013901201,
0.008617669,
-0.0029778685,
-0.026014337,
-0.0028585522,
-0.010876278,
-0.021524007,
0.009451203,
0.00445672,
-0.0138877565,
-0.0036567957,
-0.006638025,
-0.000026993235,
0.009686475,
0.00111418,
0.029496359,
-0.035357986,
0.0028215807,
-0.018673858,
0.008778999,
-0.01412975,
-0.010681339,
0.018230202,
0.015716154,
-0.012624011,
0.035815086,
-0.014317968,
0.008342065,
0.0017116022,
0.04009031,
-0.011790477,
-0.00789841,
0.0033005269,
0.0097268075,
0.0022216379,
-0.004853321,
0.010714949,
-0.002317427,
0.0035996581,
-0.020959355,
-0.031190315,
0.008617669,
-0.011380432,
0.00789841,
0.009410871,
-0.0006003632,
-0.004671825,
-0.056196343,
-0.019198177,
0.021846665,
-0.00891344,
0.006463252,
-0.014412077,
-0.035707533,
-0.0077438024,
-0.011333378,
0.0014183527,
0.013141609,
0.016253918,
-0.0035257156,
-0.039256778,
0.00023233087,
0.05840118,
-0.038235024,
-0.00462141,
-0.011743423,
-0.006268312,
-0.010278015,
0.011797199,
-0.015057393,
0.03863835,
0.010210795,
-0.004806266,
-0.017759658,
0.028528383,
-0.019682165,
0.020045156,
-0.009915025,
0.010170463,
0.018041985,
-0.0075152526,
-0.021981105,
-0.008994104,
0.00789841,
-0.004644937,
0.0003655115,
0.026336994,
-0.03097521,
0.027587296,
-0.014049086,
0.014976729,
0.0065472773,
0.01081578,
-0.041542273,
-0.030948322,
-0.020488812,
0.0022182767,
-0.013323105,
0.00093604554,
-0.0037340992,
-0.0070447093,
-0.016482469,
0.010930055,
-0.014842288,
0.0012234133,
-0.0024804368,
-0.01504395,
0.015958149,
0.023648174,
-0.011911474,
0.007138818,
-0.026982311,
0.008113516,
-0.014049086,
-0.0037979586,
0.011487985,
0.009424315,
0.0065271114,
-0.018821742,
-0.009746973,
0.0031526417,
0.028071284,
0.0053776405,
-0.054099064,
-0.012395462,
-0.038665235,
-0.0057809637,
0.022478538,
-0.008395841,
0.01242235,
0.0028803986,
-0.0035660479,
-0.0023880086,
-0.010701505,
0.008483228,
0.006590971,
-0.00061086635,
-0.0027358746,
0.021201348,
-0.007521975,
0.013968421,
-0.0012267743,
0.0051390077,
0.024051497,
-0.015662378,
-0.0029392168,
-0.030625664,
0.02454893,
0.0050516212,
-0.030894546,
0.024468265,
0.03409424,
0.00034240447,
0.03576131,
-0.020771137,
-0.013968421,
0.029738352,
-0.025059804,
0.037213273,
-0.029442582,
-0.0055255257,
-0.017302558,
0.020152709,
0.005011289,
0.000373704,
-0.008577337,
0.0026753761,
0.001294835,
0.012408906,
-0.014801956,
0.007293425,
0.009484814,
-0.015689267,
-0.005175979,
0.020959355,
0.016630353,
0.039471883,
-0.0017914266,
0.011588816,
-0.0018031901,
0.012939948,
-0.011481263,
-0.013034057,
-0.010331792,
-0.023715395,
-0.015474161,
-0.0067086066,
0.008100071,
0.011071217,
-0.005172618,
0.011857698,
-0.013410491,
0.039256778,
-0.016106034,
0.011918196,
0.010614119,
0.00017435319,
-0.002776207,
-0.014102862,
-0.031405423,
0.027775513,
0.009202488,
0.0034013577,
0.024790924,
-0.0013721386,
0.016482469,
-0.01029146,
0.009767139,
0.009047881,
0.0048096273,
0.0021779444,
-0.0049911225,
0.03893412,
0.037213273,
0.010930055,
-0.004480247,
0.013262606,
-0.04221448,
-0.029442582,
0.026457991,
0.0011553525,
-0.008879829,
-0.02094591,
0.0033845527,
-0.0045205792,
0.017517664,
0.0015746404,
-0.027936842,
0.012348407,
0.01111155,
0.029308142,
-0.0035089105,
-0.014775068,
0.007380812,
-0.0035122714,
-0.041972484,
0.0038954285,
0.022182768,
-0.008200902,
-0.0023275102,
-0.03067944,
0.009928469,
0.0059120436,
0.00090327556,
0.0013998671,
0.017678993,
-0.0066884407,
-0.01533972,
0.0018502445,
-0.012617289,
0.02589334,
0.009625977,
0.01741011,
0.010318348,
-0.0045911605,
-0.0065170284,
-0.023809504,
-0.019090625,
0.023836393,
-0.005518804,
-0.03858457,
-0.0052465606,
-0.0060969,
-0.023554066,
0.00030858413,
-0.019695608,
-0.0041441442,
-0.012664343,
0.015716154,
0.0065271114,
0.006856492,
0.018606637,
0.032238957,
0.0073404796,
-0.013941533,
-0.014828844,
-0.0005869191,
-0.019856937,
0.021739112,
0.030652551,
-0.01675135,
0.002100641,
0.0035391597,
-0.0048634037,
-0.0021628197,
-0.0003438749,
0.02812506,
-0.008846219,
-0.0012965156,
0.002586309,
0.005028094,
-0.008731944,
-0.0074076997,
0.024710258,
-0.010304904,
0.0072060386,
0.008530282,
0.0033475813,
-0.0083555095,
0.012785341,
0.01576993,
0.015353164,
0.009370538,
0.0061305105,
0.010486399,
0.030760104,
-0.0015847235,
-0.017974764,
-0.017773103,
0.02402461,
-0.0011881224,
0.007884965,
0.003717294,
-0.032454062,
-0.00252413,
0.016227031,
-0.018983072,
0.0015200237,
0.020919021,
0.020502254,
0.010499843,
-0.007286703,
0.0029644244,
0.008476506,
0.01750422,
0.0142641915,
-0.0022367623,
-0.0104124565,
0.017168118,
-0.021134127,
0.0064128363,
0.007542141,
-0.014210415,
0.005952376,
-0.016428692,
0.0025123665,
0.009599089,
-0.028904818,
-0.009578923,
-0.014909509,
0.013141609,
0.0032870828,
-0.0186873,
0.009975524,
0.0060532065,
-0.022290321,
-0.024938809,
-0.024871588,
0.0011679563,
-0.023836393,
-0.040628076,
0.01937295,
0.027560407,
-0.0026064753,
0.012953392,
0.02261298,
-0.0060229576,
0.03081388,
-0.012045915,
-0.035868865,
-0.004214726,
-0.008012684,
0.009094935,
0.0048096273,
0.0038752623,
-0.010419179,
-0.026915092,
0.016818572,
-0.00399962,
-0.009699919,
0.008745388,
-0.005562497,
-0.014479297,
0.009525146,
0.042375807,
0.0024182578,
-0.0035391597,
-0.01576993,
-0.04622082,
-0.021564338,
-0.024723703,
-0.01757144,
-0.0091285445,
-0.013175219,
0.016052257,
0.019641832,
-0.02304319,
-0.032884274,
0.004231531,
-0.018431863,
0.0013494517,
-0.00891344,
0.012758452,
0.026229441,
0.01779999,
0.017114341,
0.025328686,
-0.019628389,
-0.01347099,
-0.033287596,
0.03334137,
-0.013134887,
-0.030437445,
0.014788512,
0.026995756,
-0.029146813,
-0.0049844007,
-0.014667515,
-0.021792889,
0.016428692,
0.00008922472,
-0.012173634,
-0.02235754,
0.011212381,
0.0049642343,
0.019520836,
-0.008577337,
-0.01511117,
-0.00037769522,
0.017100897,
0.00035605862,
-0.015070838,
0.010378846,
-0.03635285,
0.0030669356,
0.018821742,
0.027909955,
0.018041985,
-0.0058817943,
-0.0053473916,
-0.026632765,
-0.0011923237,
-0.013780204,
-0.0213089,
0.008086627,
-0.027130198,
0.023486845,
0.02356751,
0.03664862,
0.002041823,
0.019561168,
-0.00045962023,
0.009619255,
0.006594332,
0.013054223,
0.029146813,
-0.009115101,
0.024871588,
0.010224239,
-0.022760864,
0.0043121953,
-0.02596056,
0.02454893,
0.02379606,
-0.018270534,
-0.016334584,
0.015648935,
-0.03500844,
-0.038530797,
0.011662758,
0.0019073819,
-0.0030266033,
-0.034282457,
-0.0032433895,
0.020394702,
0.024925364,
0.0065304725,
0.007273259,
0.01878141,
0.002776207,
0.013054223,
0.00087890815,
0.025557237,
-0.008550448,
-0.030733217,
0.00068943034,
0.003562687,
0.011447652,
-0.0034114409,
0.0022199573,
0.009323484,
-0.013363437,
0.012092969,
0.0065405555,
-0.014277636,
-0.017477332,
-0.02235754,
-0.022653311,
-0.021255124,
-0.032131404,
-0.007548863,
-0.023836393,
-0.001865369,
-0.0041643106,
-0.019184733,
0.0056498838,
0.0025442962,
-0.02065014,
0.04920541,
-0.007548863,
0.045010854,
-0.024280047,
0.009370538,
-0.0025947115,
0.00924282,
-0.028232614,
-0.015245611,
0.004897014,
-0.0013385284,
0.024011165,
0.035680644,
-0.004671825,
-0.008852941,
0.0049944837,
0.018794853,
0.012092969,
-0.015259055,
0.022249987,
0.011360266,
0.00076883455,
-0.02169878,
0.0035324376,
-0.044795748,
0.018391531,
0.013511322,
0.016509356,
0.005723826,
-0.011629147,
-0.027264638,
0.038503908,
-0.011803921,
0.0022334014,
-0.01199886,
-0.01255679,
0.008382398,
-0.039579436,
-0.01910407,
-0.016038813,
0.0010503205,
0.039848316,
-0.0065607214,
-0.0035895752,
0.005962459,
-0.00111418,
0.0065842485,
0.0036198243,
0.007185872,
0.038772788,
-0.0028652742,
-0.0030030762,
0.023016302,
0.005844823,
0.013067666,
-0.00766986,
0.016307695,
0.015218723,
-0.032964937,
-0.029980347,
0.035492428,
0.0020787942,
-0.012395462,
0.006436364,
-0.015662378,
-0.011098105,
-0.012005582,
-0.025463128,
0.00045205792,
-0.055282146,
0.014775068,
0.011138438,
0.015353164,
0.024347268,
0.018996516,
0.0040634796,
-0.001324244,
0.03186252,
-0.020488812,
0.020448478,
0.021712223,
0.015366608,
-0.017934432,
0.0032030572,
0.0083555095,
-0.03097521,
-0.0048465985,
-0.025745455,
-0.033637144,
-0.0023409543,
0.023406181,
0.012395462,
0.017356334,
-0.007918576,
0.027103309,
0.0104796775,
0.023661619,
0.020435035,
-0.0016410206,
0.010795614,
-0.02183322,
-0.030249229,
0.018673858,
-0.012617289,
0.0005175979,
0.0032870828,
0.008604225,
0.021376122,
-0.021201348,
-0.02661932,
-0.008301733,
-0.012449238,
-0.013639041,
-0.00091587944,
-0.02543624,
-0.0058817943,
-0.015259055,
0.0016292571,
0.0019225065,
-0.017531108,
-0.010419179,
-0.005653245,
-0.005034816,
0.022868417,
-0.023244852,
0.004890292,
0.008805887,
-0.024885032,
-0.051948007,
0.0068060765,
-0.031512976,
0.032857385,
-0.0036534346,
-0.030652551,
-0.012677788,
0.0024955613,
-0.027210861,
-0.03414802,
0.0034921053,
-0.007562307,
-0.008893273,
0.0036601566,
-0.046866138,
0.01081578,
-0.011595538,
0.027883066,
-0.0028854404,
-0.021604672,
0.010493121,
0.0055389698,
0.026296662,
-0.00878572,
-0.015877483,
-0.0073472015,
0.049339853,
0.00711193,
-0.014344856,
0.0058044908,
-0.014412077,
0.02730497,
-0.026444547,
0.01727567,
0.0037777924,
0.0077370806,
0.019292286,
-0.02887793,
-0.002251887,
0.009431037,
-0.012072803,
-0.010472955,
-0.017692437,
0.0002808557,
-0.001979644,
0.015097726,
-0.008113516,
-0.044257984,
0.03662173,
-0.018808298,
0.025463128,
0.010788891,
-0.0018972988,
-0.010466233,
0.007656416,
0.006133871,
-0.008725222,
-0.020340925,
-0.010116686,
0.01212658,
-0.016657243,
0.003996259,
-0.026242886,
-0.006365782,
0.012570235,
-0.017947875,
-0.016482469,
0.00053776405,
-0.020273706,
-0.043532,
0.030894546,
0.007831189,
-0.010109965,
-0.0039122337,
0.011172049,
-0.026108446,
-0.013437379,
0.024333823,
-0.0029392168,
-0.0108561115,
-0.0048499596,
-0.009020993,
-0.015474161,
-0.022465093,
-0.01766555,
-0.008684889,
-0.00082219084,
0.006264951,
0.18864763,
-0.01704712,
-0.0039290385,
-0.014344856,
-0.009451203,
0.0024115357,
0.012899616,
0.0013914645,
0.005945654,
-0.011003997,
0.020529144,
0.016401803,
-0.0069237123,
0.0051961453,
0.0057540755,
-0.026955424,
-0.01871419,
0.0017494137,
-0.02766796,
-0.01684546,
0.028393943,
0.00047558508,
0.00022581889,
-0.016711019,
0.026901647,
-0.008745388,
-0.023016302,
-0.021376122,
0.017235339,
0.009262986,
-0.033287596,
0.027520075,
-0.010083077,
-0.009525146,
0.0030585332,
-0.0014099502,
-0.0064397245,
-0.009316762,
0.010271293,
0.006520389,
-0.014559962,
0.0032517922,
-0.017450444,
0.01081578,
0.015985036,
0.018297423,
0.005666689,
-0.020139264,
-0.014250748,
-0.009941913,
-0.025758898,
-0.009827638,
0.010446067,
0.01301389,
0.011716534,
0.003045089,
0.011797199,
0.00041151553,
-0.024871588,
0.035089105,
-0.017934432,
0.016670685,
-0.025221134,
0.039014783,
-0.026363883,
0.011642592,
-0.015070838,
0.0051356466,
0.009861249,
-0.011205658,
0.0005188583,
0.0063019227,
-0.0010410777,
-0.008093349,
-0.023446513,
-0.012597123,
0.007031265,
0.0007448873,
0.005189423,
0.02511358,
0.018633524,
0.0068060765,
-0.019009959,
-0.017907543,
0.0121938,
-0.013094555,
0.018216757,
0.0029879515,
-0.019709053,
-0.009047881,
0.002910648,
-0.013444101,
-0.004248336,
-0.009491536,
0.017584885,
0.008140404,
-0.00029030856,
0.0003972312,
0.0089739375,
-0.0049944837,
-0.009101657,
0.07125374,
0.0049675955,
0.010755281,
0.004601244,
0.008301733,
0.0046651033,
-0.011871141,
-0.013141609,
-0.017584885,
0.002500603,
-0.032507837,
0.015232167,
-0.0025577403,
0.0010872917,
0.022330653,
-0.0066783573,
-0.0030266033,
0.01324244,
0.0049608736,
0.0030988655,
-0.031163428,
-0.0009099976,
0.039767653,
-0.026659653,
-0.008516839,
-0.02055603,
0.0042785853,
-0.010876278,
-0.023688506,
0.0063960315,
-0.0017763019,
-0.0028501495,
0.015783375,
0.0015788417,
-0.01946706,
-0.00030270233,
-0.023513734,
-0.043747105,
0.01238874,
0.0010217517,
-0.0060969,
0.019225065,
-0.00050037267,
-0.0035996581,
0.0017090813,
0.018283978,
0.011131716,
-0.020663584,
-0.018499084,
-0.00034240447,
-0.023930501,
-0.0012301353,
-0.015837152,
0.02553035,
-0.023930501,
-0.0066749966,
-0.0007574911,
0.025758898,
0.0070917634,
-0.027291527,
0.01065445,
-0.008147125,
0.00898066,
0.0047054356,
-0.009975524,
-0.16853526,
0.005686855,
0.0044466364,
-0.030276116,
0.018136093,
0.040063422,
-0.014102862,
0.025879895,
-0.009330207,
0.019924158,
0.047834113,
-0.0012645858,
-0.04589816,
0.0015553145,
-0.0020149348,
0.001684714,
-0.022411317,
0.015433828,
0.032534726,
0.020932466,
0.027775513,
-0.03307249,
0.0021997911,
-0.004755851,
0.013538211,
0.007817745,
0.006399392,
-0.008140404,
-0.023782616,
-0.018378086,
-0.014317968,
-0.0036736007,
0.021295456,
-0.0041811154,
-0.0065573603,
0.0069506005,
-0.022922194,
-0.0116089815,
0.01451963,
0.026578989,
0.029415695,
-0.00049154996,
0.009330207,
0.0045541893,
-0.011259435,
0.043209344,
0.0049642343,
-0.018364642,
0.02149712,
-0.020273706,
0.035707533,
0.0047894614,
0.015084282,
0.031512976,
0.008496672,
-0.0017410112,
-0.0063960315,
0.023325516,
0.016778238,
0.009383983,
-0.0035223546,
-0.02812506,
0.024589261,
-0.007878244,
0.008389119,
-0.033287596,
-0.015917817,
0.020179596,
-0.01599848,
0.0062716734,
-0.008731944,
0.00088815094,
0.0072194827,
-0.016025368,
0.0028753572,
0.0126710655,
-0.016724462,
0.008409286,
0.015312832,
-0.003369428,
0.0037945977,
0.0014662474,
-0.01796132,
-0.024360713,
-0.021685336,
-0.0048230714,
-0.0018115927,
0.008994104,
-0.0056465226,
0.0039155944,
-0.0061775646,
-0.0061910087,
-0.017342892,
0.0014897746,
0.021228237,
0.03412113,
-0.01006291,
-0.023822948,
0.010197351,
0.013410491,
0.005471749,
-0.016038813,
-0.030195452,
-0.009054602,
0.0100293,
-0.0045474675,
-0.034685783,
0.0035223546,
0.053776406,
-0.011924918,
0.008093349,
0.022478538,
0.015164946,
0.009289874,
0.0073203132,
0.009612532,
0.009027714,
-0.00383493,
0.020166153,
-0.01848564,
0.053157978,
-0.014842288,
-0.02035437,
0.030894546,
-0.0033845527,
-0.0076631377,
-0.15035883,
-0.021618115,
-0.00583474,
0.022787752,
-0.028367054,
0.008200902,
-0.0008108474,
0.0134239355,
-0.02058292,
0.015689267,
-0.037025057,
-0.0117635885,
-0.0012368574,
-0.01907718,
0.012435794,
0.020569475,
0.006348977,
-0.013995309,
-0.01245596,
0.02602778,
0.01340377,
-0.0057607973,
-0.03309938,
-0.017369779,
0.0066918014,
-0.001068806,
-0.039794542,
0.022276876,
0.013255884,
0.023419624,
0.018620081,
-0.0026215997,
0.049581848,
-0.009988967,
-0.023191076,
0.0085975025,
0.002137612,
-0.033448923,
0.03565376,
-0.0037912366,
-0.018136093,
-0.0041676713,
0.0062750345,
-0.0064262804,
0.0072262045,
-0.01212658,
-0.014102862,
0.0030635747,
0.030464334,
-0.01406253,
-0.025611013,
-0.043585777,
-0.040224753,
-0.021577783,
0.009746973,
-0.010546898,
0.00409709,
0.026955424,
-0.008745388,
0.0034786612,
0.02717053,
-0.0050785094,
-0.009585644,
0.009814194,
0.04084318,
-0.0009940233,
-0.0021745835,
-0.03740149,
0.031163428,
-0.023970833,
-0.0012671066,
0.01615981,
-0.035035327,
-0.0019746025,
-0.00085832184,
0.02311041,
-0.002645127,
-0.012012305,
0.004110534,
-0.025046362,
-0.015487605,
-0.01884863,
0.009283152,
0.0045340233,
0.043854658,
0.005286893,
0.022142434,
-0.00439286,
0.012368574,
-0.020623252,
-0.001796468,
0.029281253,
0.0035660479,
-0.014976729,
-0.029953457,
0.013034057,
-0.0046785474,
0.007024543,
0.03858457,
0.022532314,
-0.013228996,
-0.011024163,
-0.05915405,
0.017383223,
-0.0020871968,
0.022290321,
0.013746594,
-0.04562928,
-0.0019325896,
-0.01832431,
0.013820536,
0.02304319,
0.00079950393,
-0.005821296,
0.0020535865,
0.0041945595,
-0.033583365,
-0.016576577,
0.027197417,
-0.017369779,
0.01782688,
0.034013577,
-0.008832775,
-0.012166912,
0.0029577024,
0.022733975,
-0.00537428,
0.009941913,
0.00245859,
0.021712223,
-0.0012141704,
0.009034436,
0.017168118,
-0.028635936,
-0.01907718,
0.007138818,
-0.022169324,
-0.024764035,
0.0066850795,
0.019762829,
0.015904373,
0.02858216,
-0.007266537,
-0.03159364,
0.015743043,
-0.014976729,
-0.010889722,
-0.00927643,
-0.026699986,
0.00059112033,
0.028151948,
-0.018082317,
0.041811157,
-0.0026434464,
0.015541381,
-0.02901237,
0.004140783,
-0.006348977,
-0.01668413,
-0.00090159505,
-0.0049339854,
-0.010056188,
0.007246371,
0.0483181,
0.027062977,
0.015299387,
0.020596363,
-0.01609259,
-0.027909955,
0.009491536,
0.00770347,
-0.00714554,
-0.019843495,
0.010930055,
0.022707088,
0.010439345,
0.0074681984,
-0.0005066746,
-0.018741077,
-0.005058343,
-0.0396601,
0.023809504,
0.0010284737,
-0.015702711,
0.008765554,
0.024522042,
0.039740764,
-0.0042987512,
0.0026703347,
0.020273706,
-0.015904373,
-0.0025560597,
-0.010714949,
0.02238443,
0.02992657,
0.023688506,
0.034605116,
0.018606637,
-0.005071787,
0.01615981,
0.027036088,
0.032884274,
-0.005844823,
-0.011259435,
0.014183527,
-0.02021993,
0.0023779254,
0.025543792,
-0.031217204,
-0.019655276,
-0.00058355805,
0.012899616,
0.008362231,
0.0026854593,
0.03006101,
-0.000059343103,
-0.028340166,
0.011992139,
0.0068060765,
0.003962649,
-0.011965251,
-0.0117635885,
0.001324244,
0.005024733,
0.0076967482,
-0.001258704,
0.004362611,
0.005031455,
0.031055875,
-0.026686542,
0.024132162,
-0.014936397,
0.023164187,
-0.00068859005,
-0.036729284,
-0.00043903393,
-0.016482469,
-0.013444101,
0.009941913,
0.014694403,
-0.01488262,
0.086096026,
0.0071993163,
-0.013450824,
-0.0035324376,
-0.0058817943,
0.0038618182,
0.00022476858,
0.0186873,
-0.012119858,
-0.029550135,
0.040224753,
-0.011750145,
0.03662173,
-0.01504395,
-0.032480948,
0.012106413,
-0.0030282838,
-0.016495913,
0.011326656,
0.006372504,
0.012066081,
-0.0040735626,
0.0043021124,
0.016186697,
-0.022559203,
-0.010728393,
0.04337067,
-0.0073740897,
-0.00026363044,
-0.003386233,
0.015003617,
-0.0031240731,
-0.052405108,
0.00031026464,
0.016052257,
-0.0183512,
-0.031970073,
-0.011091384,
0.015151503,
0.034981553,
0.004732324,
0.013672651,
-0.0091285445,
-0.012341686,
0.00044197484,
-0.004335723,
-0.016415248,
0.0034080797,
-0.0024922004
] |
Since the beginning of the 1990s the public health situation in Russia has been characterized by an extremely high mortality and a significant reduction in life expectancy. Cardiovascular diseases remained the major cause of death. Only a few large population studies were conducted in Russia during this period. A total of 1968 men and 1737 women aged 18–75 years participated in a health survey in Arkhangelsk, Russia, over the period 1999–2000. Investigation included assessment of classic cardiovascular risk factors (family history, smoking, blood pressure, and blood lipids) along with general health variables. The paper presents sex | [
-0.0008132399,
-0.00721943,
0.008127535,
-0.045612786,
-0.014607508,
-0.011137252,
-0.021003157,
0.012810758,
-0.027580427,
-0.011247521,
-0.027139349,
0.021768559,
-0.00952861,
-0.0033794458,
-0.003567553,
0.033885267,
0.03923011,
-0.022040991,
0.03762147,
-0.025284221,
-0.028592316,
0.017396685,
-0.013018325,
0.00067742966,
-0.013128595,
0.041435506,
0.024856115,
-0.0324323,
0.0037589036,
-0.022871258,
0.009794555,
-0.015917772,
-0.019874513,
-0.032536082,
-0.028488532,
0.002863772,
-0.013712376,
-0.010313472,
0.013686431,
-0.01724101,
-0.0050432226,
0.008270237,
0.0069729444,
0.010410768,
0.010170769,
0.010897253,
-0.006288623,
-0.005951327,
0.009593475,
0.022858284,
0.01350481,
0.013582647,
-0.019446407,
-0.011014009,
-0.0034605265,
-0.008873478,
-0.017578306,
0.0051664654,
0.008335101,
-0.009094017,
0.006541595,
-0.013491836,
-0.017007498,
0.00089594227,
-0.0383739,
0.012428057,
-0.014542643,
0.021431264,
-0.0051729516,
0.033029053,
0.020730726,
0.03860741,
-0.005429167,
0.036531743,
0.020990184,
-0.0034734993,
-0.010047526,
-0.010553471,
-0.009541582,
-0.008231318,
0.008237804,
-0.018201007,
0.017513443,
0.007926454,
0.0122658955,
0.0024162063,
-0.011364277,
0.022482071,
0.00797186,
-0.008704829,
0.031135008,
-0.00060891645,
0.0043816036,
0.015489667,
-0.006259434,
-0.0053351135,
-0.0033891753,
0.01625507,
0.0005736463,
-0.025855029,
-0.021820452,
-0.0037718765,
-0.00742051,
-0.004183767,
-0.025595572,
0.0038302545,
-0.015852908,
-0.014373995,
0.024376117,
-0.0011586439,
-0.010910226,
0.030797713,
0.014399941,
-0.024830168,
0.018590195,
-0.026646378,
0.0017805332,
-0.013199946,
0.003914579,
-0.012583733,
0.009872392,
0.001120536,
0.01434805,
-0.0034053915,
-0.00053999777,
-0.01244103,
-0.02407774,
0.010397796,
0.014335076,
0.005409708,
-0.014075618,
-0.015801016,
0.00428755,
-0.011974005,
0.0014643184,
0.01696858,
-0.028722044,
-0.008309155,
-0.022871258,
-0.026348,
-0.0083934795,
0.023455039,
-0.021080995,
-0.024337199,
0.018265871,
0.043744687,
0.027217185,
0.012758867,
0.002425936,
0.0057697063,
0.009839959,
-0.022715583,
0.020795591,
-0.00910699,
0.014088591,
-0.0064734872,
-0.017746955,
0.02621827,
0.0047902507,
-0.012116707,
0.0077642924,
0.007673482,
-0.010306985,
-0.0087956395,
-0.020458294,
0.013219405,
0.017474523,
0.0024016118,
0.0061848396,
0.0032156624,
0.0018940463,
0.03878903,
-0.024895033,
0.0123048145,
0.03435229,
0.025751246,
-0.017928576,
0.013277784,
-0.036453906,
-0.013569674,
-0.012363193,
0.015528585,
0.0336777,
0.018771816,
-0.006207542,
0.013238865,
0.036012825,
0.0031021496,
0.009113477,
-0.004355658,
0.003862687,
0.01755236,
-0.013180487,
-0.0274507,
-0.6584016,
-0.022598827,
-0.010618335,
-0.00428755,
0.027943669,
0.009593475,
0.01750047,
0.024765303,
-0.011571845,
0.019615054,
-0.012732921,
0.008386993,
0.0071415924,
-0.004018362,
-0.02407774,
-0.019303706,
-0.00092432054,
0.014192374,
0.0068432153,
0.009982662,
-0.013842106,
0.016177231,
0.005399978,
0.023429094,
-0.021042077,
0.007122133,
0.004907007,
-0.038866866,
-0.0000977023,
0.017189119,
0.006204299,
0.017565334,
-0.0064086225,
0.030797713,
0.040371727,
-0.035831206,
0.009807527,
0.030408524,
0.022183694,
0.02719124,
-0.038970653,
0.013686431,
0.0064151087,
-0.0040572807,
0.0153339915,
0.0069015934,
0.022248557,
0.0075113205,
0.018032359,
0.0013475621,
-0.0028410694,
-0.010903739,
-0.010060499,
0.0042680907,
-0.0005395924,
-0.0076799686,
0.012019411,
-0.0037491738,
-0.022741528,
-0.023740444,
-0.008341587,
0.010910226,
-0.021833424,
0.005948084,
-0.01781182,
0.025777193,
-0.010722118,
0.02420747,
-0.008918882,
-0.017850738,
0.01683885,
0.027398806,
-0.0052702487,
-0.015165343,
0.033029053,
0.014555616,
0.030512307,
0.012136167,
-0.022028018,
-0.021833424,
0.0013678323,
0.007602131,
-0.013491836,
0.006220515,
0.00045080896,
-0.009184827,
-0.017837765,
0.010475633,
-0.0031524196,
0.00075405097,
0.005961057,
0.009119962,
-0.0046443054,
-0.0033826889,
0.009171855,
0.021483155,
-0.0035124181,
-0.0076799686,
0.008841045,
-0.0013629674,
-0.020497214,
-0.009846446,
0.011104819,
0.0077059143,
0.004401063,
0.0129469745,
-0.040527403,
-0.0077513196,
0.04091659,
-0.027346915,
0.01035239,
-0.012045356,
-0.005458356,
-0.009061584,
-0.0032594462,
-0.021833424,
0.026360974,
0.0039275517,
0.029785825,
-0.026192326,
0.026827998,
0.0114031965,
0.014114537,
-0.016605338,
0.009638879,
0.019757757,
-0.012732921,
0.0013062109,
-0.00058945705,
-0.025803138,
0.035597693,
0.0063664606,
0.040449563,
0.002476206,
0.01275238,
-0.013842106,
0.00690808,
-0.00010773604,
-0.0069015934,
0.00888645,
-0.008257263,
-0.0045275493,
0.0022232342,
-0.0031264736,
-0.0009802663,
-0.006869161,
0.0024599899,
-0.0076929415,
-0.014283185,
-0.002396747,
0.0074659153,
-0.025362058,
-0.0077318605,
-0.0022313423,
0.004569711,
0.001406751,
0.0017513442,
-0.009574015,
0.012869136,
-0.0044399817,
0.010086445,
0.009956716,
-0.016812904,
0.016579391,
0.0037134984,
-0.004423766,
-0.020795591,
0.026270162,
0.006006462,
-0.028670153,
0.016281014,
-0.017889656,
0.0039113355,
0.017124254,
-0.011481035,
0.020899374,
-0.029085286,
0.00054810586,
-0.015022641,
-0.01443886,
0.015580477,
-0.033885267,
-0.028151236,
0.006587,
0.028280966,
0.01599561,
0.011792384,
0.003372959,
0.00080675347,
0.010702659,
-0.023065852,
0.01484102,
-0.019641,
-0.0017432361,
0.010034554,
-0.0031572843,
-0.0051307897,
0.0022005315,
0.024908006,
0.0046734945,
0.043147933,
-0.008743748,
0.032017168,
-0.010073473,
0.011967518,
0.0072129434,
-0.0056756525,
0.00033222837,
0.012272382,
-0.00449836,
0.02955231,
0.0028313398,
-0.021301534,
-0.011824816,
-0.0065902434,
0.010170769,
-0.0027453941,
-0.0050302497,
-0.012706975,
0.007303754,
-0.01830479,
-0.016592365,
0.02435017,
-0.032717705,
-0.008328615,
0.009210773,
0.015619395,
0.01781182,
0.0015178316,
-0.021444237,
-0.010592389,
0.011662655,
0.016955607,
0.026062597,
0.0025248546,
0.014698318,
0.0035221477,
-0.014503725,
0.013634539,
0.024038821,
0.0075632124,
-0.014633453,
0.023273418,
-0.0119286,
-0.009165368,
-0.01817506,
0.026296109,
0.0025280977,
-0.022002073,
0.005993489,
0.0007212133,
0.0034378238,
-0.0038594436,
-0.005672409,
-0.020289646,
-0.017798847,
0.016047502,
-0.0033599862,
0.023117743,
0.039826863,
0.043485228,
0.000035396813,
0.009483204,
0.0048324126,
-0.009450772,
-0.0011643196,
-0.02488206,
-0.010384822,
0.0045048464,
-0.004255118,
-0.015658315,
-0.0068951068,
0.0058118682,
-0.031705815,
0.011377251,
0.015839934,
0.0072842943,
0.0020740456,
0.017850738,
0.0017610738,
-0.016332906,
-0.009749149,
0.012103735,
0.013829133,
-0.0060518673,
-0.0305642,
0.01253184,
0.0038853895,
-0.02981177,
0.022352342,
0.019757757,
0.00070905115,
-0.01692966,
-0.0027599887,
-0.02843664,
0.0035448503,
0.016229123,
-0.017850738,
0.000059847727,
-0.0083740195,
0.004881061,
-0.021210724,
0.009366448,
-0.013621566,
0.023558823,
0.0048972773,
-0.0003476337,
-0.0017513442,
0.0016443176,
0.009775096,
-0.013971834,
-0.008665911,
-0.012791299,
0.007835643,
0.005756733,
0.03038258,
-0.018953435,
-0.0037167415,
-0.012849677,
-0.014866966,
0.000013340317,
-0.021470182,
-0.020756671,
-0.034170672,
0.089928284,
-0.0054810587,
0.003921065,
0.010274553,
0.009775096,
-0.0069015934,
0.0076215905,
-0.03684309,
0.012778326,
0.026516648,
0.018317763,
-0.015035614,
0.0010686442,
0.0033470134,
0.024298279,
0.013621566,
-0.00032797162,
-0.021470182,
-0.0015299937,
-0.002375666,
0.02057505,
-0.006541595,
0.011779412,
0.054226805,
0.026296109,
-0.000020422214,
-0.0029789067,
0.004923223,
0.019264786,
-0.004945926,
-0.0071545653,
0.0318096,
-0.012175085,
0.029707987,
-0.008108075,
0.02843664,
0.031705815,
-0.001621615,
0.011014009,
0.0144518325,
0.032536082,
-0.007050782,
-0.003820525,
0.0063502444,
0.028644208,
-0.019498298,
-0.00037459307,
0.010812929,
0.017422631,
-0.01990046,
0.037880927,
-0.0012316166,
-0.021496128,
-0.030979333,
0.007517807,
-0.0030307984,
0.017202092,
-0.009781581,
-0.032069057,
0.0068497015,
0.004258361,
-0.021716667,
0.0085751,
-0.0035480936,
-0.023805307,
0.010559957,
-0.031005278,
0.004018362,
-0.019705866,
0.011636709,
0.008633479,
-0.006434568,
-0.0023108013,
0.01768209,
-0.0063242987,
0.007874562,
0.008322128,
-0.0380366,
-0.0031751222,
0.015801016,
-0.013530755,
0.0133880535,
-0.013070216,
-0.013647512,
-0.012116707,
0.00048283587,
-0.028644208,
-0.048726287,
-0.015632369,
0.001289184,
-0.007148079,
-0.0015526963,
-0.00797186,
-0.017111281,
-0.009885365,
0.02416855,
-0.0008740505,
0.039074436,
-0.025037736,
-0.0061426777,
-0.0056886254,
-0.0075826715,
-0.02057505,
-0.0051243035,
-0.0021210725,
-0.011682115,
-0.011052928,
0.013206433,
-0.009625907,
-0.01350481,
0.011422656,
-0.024804223,
0.010488606,
0.010936172,
0.033003107,
0.018032359,
0.018499384,
0.03549391,
0.02257288,
-0.010047526,
0.0000014268312,
0.021184778,
0.008691857,
0.018499384,
-0.025517734,
0.016631283,
0.008672397,
-0.03123879,
-0.049011692,
0.004089713,
0.0016029665,
0.0125513,
-0.011986978,
-0.048492774,
-0.020717753,
0.005724301,
-0.015489667,
-0.0071999705,
0.0050788983,
-0.014270212,
-0.037751198,
0.0063794334,
-0.018823707,
-0.016008584,
0.03917822,
-0.032146897,
0.013543729,
-0.0012397247,
-0.02141829,
-0.0041934964,
-0.01381616,
-0.012252923,
-0.011597791,
0.0071286196,
-0.010332931,
-0.0031135008,
-0.0119286,
-0.005176195,
0.023896119,
-0.00060242997,
0.03655769,
0.01170806,
0.008834559,
0.012110221,
0.01119563,
0.0050270064,
0.008023751,
0.0116237365,
-0.003596742,
0.030045282,
0.029656095,
0.008406452,
-0.023909092,
-0.025686381,
0.0040248483,
-0.005474572,
0.0026951241,
-0.021755587,
-0.016410744,
-0.025388004,
0.012998866,
-0.0013037785,
-0.03105717,
0.012499409,
-0.03528634,
-0.017098308,
0.025855029,
-0.015580477,
-0.010216175,
-0.020795591,
-0.015749125,
-0.010890766,
0.0219891,
-0.0034734993,
-0.033470135,
-0.0020383701,
-0.0045178193,
-0.004430252,
0.016332906,
0.0055459235,
0.011714547,
0.028358802,
0.01181833,
-0.008866991,
-0.0057599763,
0.014983723,
-0.031472303,
-0.021379372,
0.008023751,
-0.017396685,
0.0011148603,
-0.007589158,
-0.023026932,
-0.033340406,
-0.011759952,
-0.00089432066,
0.0019653973,
0.03162798,
-0.019498298,
-0.01359562,
-0.013764268,
-0.0077383467,
0.005782679,
0.0013232378,
0.042629015,
0.014309131,
-0.02830691,
-0.039282,
0.024998818,
0.020847483,
0.00066729455,
0.018888572,
0.01139671,
-0.023221526,
0.0019816135,
-0.000692835,
0.030590145,
-0.016605338,
-0.036946878,
0.044367388,
-0.012596705,
-0.0017529659,
0.0058637597,
-0.00585403,
-0.024778277,
0.008665911,
-0.008088616,
-0.018564248,
0.0151134515,
-0.023649633,
0.00266107,
0.03523445,
-0.019666947,
0.018369654,
0.004355658,
-0.032899324,
-0.0035189046,
-0.027217185,
-0.015541558,
0.0065188925,
0.015710207,
0.01799344,
-0.008802126,
0.012058329,
-0.01097509,
-0.0014570211,
0.005925381,
0.016475609,
-0.022002073,
0.032691758,
-0.0024016118,
-0.017033445,
0.02004316,
-0.016709121,
0.0050010607,
0.014646427,
-0.0171502,
-0.023597741,
-0.028618261,
-0.008341587,
0.017604252,
0.0009299962,
-0.012408598,
0.00090242876,
-0.030979333,
-0.033003107,
-0.016540473,
-0.010261579,
0.0087956395,
-0.024531791,
-0.017383713,
-0.007647536,
-0.0054940316,
0.004991331,
0.011052928,
-0.008315641,
-0.003238365,
0.02043235,
-0.025452869,
0.017746955,
0.018849652,
0.017941548,
-0.013686431,
0.025336113,
-0.027787995,
-0.0070313225,
-0.0010426984,
0.031446356,
-0.03852957,
-0.0477144,
0.0055459235,
0.017630199,
0.028358802,
0.0027113403,
0.032769594,
-0.007991319,
-0.01128644,
-0.028099345,
-0.015775071,
0.03917822,
-0.01594372,
0.023429094,
0.0066940268,
-0.020185864,
0.023571795,
-0.029111233,
0.032069057,
0.0127264345,
0.0038107953,
-0.020419376,
-0.016786959,
0.010767523,
-0.0096777985,
0.0036778229,
-0.028981503,
0.0073686186,
-0.017941548,
0.024985844,
0.02270261,
-0.0075048343,
0.015385883,
0.019264786,
0.0011651304,
-0.004225929,
0.0023789092,
-0.007595645,
0.0075761853,
0.011597791,
-0.0010516173,
-0.008536181,
0.0090356385,
0.034196615,
0.024220442,
-0.009132936,
-0.014763183,
-0.01705939,
-0.052254923,
0.0012275625,
-0.010611849,
0.046910077,
-0.0019945865,
0.025011789,
0.0066615944,
0.014944804,
0.0019216138,
0.017617226,
-0.024817197,
-0.024272334,
0.015385883,
-0.0036356607,
0.010689686,
0.00035047153,
-0.01639777,
-0.0030729603,
0.028229075,
-0.015723178,
-0.023403147,
0.0038432276,
-0.0114421155,
-0.0024664763,
-0.02350693,
-0.0036616067,
-0.008834559,
-0.008931856,
-0.0036453905,
-0.02647773,
0.0065188925,
-0.0085751,
-0.0069729444,
-0.0054778154,
-0.009522123,
-0.01297292,
0.01064428,
-0.007926454,
-0.03513067,
-0.024129631,
-0.0018859382,
-0.018421546,
0.023896119,
0.028540423,
0.0027616103,
0.029837716,
-0.0051826816,
0.0046637645,
0.0048291693,
-0.0077513196,
-0.017824791,
-0.0116431955,
0.0038724167,
0.003823768,
-0.008101588,
-0.0100799585,
0.0075696986,
0.0023545849,
-0.0026935025,
-0.0140107535,
-0.04234361,
-0.010962117,
0.018330736,
-0.004423766,
0.0035999853,
0.011039955,
0.014931831,
-0.019537218,
-0.0065805134,
-0.010546984,
0.017630199,
-0.0033307972,
-0.006288623,
0.025660435,
0.0044918736,
-0.021301534,
-0.0002805394,
0.004793494,
-0.012629137,
0.022650719,
0.18120575,
-0.013180487,
-0.0031216089,
0.009697258,
-0.005163222,
-0.0012705354,
0.014114537,
-0.011552385,
0.0033567431,
0.034092832,
-0.0031426898,
0.008023751,
-0.0035999853,
0.011331846,
0.008549154,
-0.022443151,
-0.032069057,
-0.010054013,
-0.0033210674,
0.0092561785,
-0.018836679,
0.0062691635,
-0.007900508,
-0.014516697,
0.013452918,
0.013712376,
-0.010332931,
0.0031232305,
0.0219891,
-0.01977073,
0.00012283733,
-0.02297504,
0.010034554,
-0.0011440493,
-0.016748039,
-0.02283234,
0.011662655,
-0.005344843,
0.025310166,
-0.020652888,
0.002059451,
-0.0056075444,
0.0036453905,
-0.017266957,
0.009003206,
0.036246337,
-0.009794555,
-0.017708035,
-0.027865833,
-0.016722094,
-0.040423617,
-0.015969664,
0.011247521,
0.00036040394,
-0.004329712,
0.02003019,
0.03860741,
0.004008632,
-0.013050757,
-0.0008651316,
-0.006330785,
-0.006992404,
-0.029967446,
0.017253984,
-0.027424753,
0.05645815,
-0.0049264664,
0.004216199,
-0.0067913234,
-0.018226953,
0.008458344,
-0.02154802,
-0.027865833,
0.006992404,
-0.0029383663,
-0.0026270163,
0.020549105,
0.04185064,
0.013005353,
0.011078874,
-0.0062497044,
-0.011247521,
-0.0068756477,
0.024116658,
-0.03251014,
-0.020017216,
0.009288611,
0.0146723725,
-0.025530707,
-0.002025397,
-0.0005935111,
-0.007193484,
-0.007102674,
0.008678883,
0.04447117,
0.00647673,
-0.0010394552,
0.003222149,
0.007401051,
-0.015775071,
-0.017487496,
0.060817048,
-0.001040266,
0.00993077,
-0.00797186,
-0.014361022,
-0.038062546,
0.023688551,
0.012447516,
-0.03762147,
0.00066324056,
-0.024843141,
0.0021632344,
-0.017591279,
0.013323189,
0.009833474,
0.037829034,
-0.02336423,
-0.011571845,
-0.019161003,
-0.020847483,
-0.027113402,
0.0035091748,
0.030693928,
-0.0066064596,
-0.022326395,
-0.04270685,
-0.018836679,
-0.014828048,
-0.04317388,
0.013413999,
-0.015762098,
-0.0098788785,
-0.0034897155,
-0.0022508015,
-0.0038886326,
-0.003921065,
0.002468098,
-0.010676713,
0.010306985,
0.0036551203,
-0.023571795,
0.00067418645,
0.008412939,
0.020600997,
0.0015462099,
-0.0022297206,
0.0151134515,
-0.0036486338,
0.027580427,
-0.013206433,
-0.012012924,
-0.0071286196,
0.008049697,
0.03603877,
-0.015878854,
-0.0030259336,
-0.026010705,
-0.014399941,
0.019757757,
-0.022910176,
0.009321043,
0.03510472,
-0.018447492,
-0.005156736,
0.005925381,
-0.16356258,
0.02981177,
-0.0075502396,
-0.02900745,
0.0030583658,
0.004144848,
0.015839934,
0.004044308,
0.0020610727,
0.0048616016,
0.030460415,
0.017344793,
0.0017659387,
-0.02297504,
0.0159048,
-0.014633453,
-0.010255093,
0.041591182,
0.026503675,
0.006992404,
0.027658265,
-0.0035091748,
0.0028929613,
-0.013777241,
-0.008438884,
-0.000650673,
-0.012071302,
0.0019686406,
-0.0027567456,
-0.018045332,
-0.042395502,
0.011351305,
0.024453955,
0.004864845,
-0.031913385,
0.010832388,
-0.012194545,
-0.03256203,
-0.013452918,
0.010456174,
0.02479125,
0.019070193,
-0.0123048145,
-0.0026399891,
-0.016268041,
-0.0056626797,
0.00073459157,
-0.021080995,
0.029656095,
-0.005526464,
0.016903715,
-0.010936172,
0.025569625,
0.010871307,
0.022105856,
0.0035740396,
-0.011318873,
0.0034216077,
0.0051956545,
0.013932916,
-0.032224733,
-0.0025345841,
0.01661831,
0.009321043,
0.009165368,
-0.011948059,
-0.0367912,
0.0017416145,
-0.004102686,
0.01923884,
-0.013323189,
0.0068756477,
0.010767523,
-0.018226953,
0.046365216,
0.0052897083,
-0.015671287,
-0.0019362083,
-0.005134033,
-0.009165368,
-0.008036724,
0.015372911,
-0.009697258,
-0.00897726,
0.0007459429,
0.009956716,
0.02017289,
-0.012389138,
-0.0000016168642,
-0.020419376,
0.016268041,
-0.040631186,
-0.0030356632,
-0.0085556405,
-0.008925369,
0.01594372,
-0.012006437,
-0.011811843,
0.012272382,
-0.0076669957,
-0.006700513,
-0.0151134515,
-0.00797186,
0.001107563,
0.026802052,
-0.0033567431,
-0.0015859394,
0.0013256703,
0.03038258,
-0.010365363,
0.0049848445,
0.016761012,
-0.0009883743,
0.017253984,
-0.005983759,
0.021742614,
0.009606447,
-0.0129275145,
0.007589158,
-0.0030567443,
0.036090665,
-0.006700513,
-0.0022718825,
0.027736103,
0.0077772653,
-0.017124254,
-0.10585903,
0.0077772653,
0.0019102625,
0.020847483,
0.02763232,
0.03852957,
-0.0011975627,
0.0085751,
0.0133491345,
0.024298279,
0.000692835,
-0.002502152,
0.008802126,
-0.02039343,
0.06704405,
-0.0073556458,
-0.011915627,
-0.02843664,
-0.016449662,
0.02003019,
-0.0021194508,
-0.028851774,
0.0028945827,
-0.008419425,
-0.021158833,
-0.011669141,
-0.015256153,
0.01139671,
0.007148079,
0.005244303,
-0.004355658,
0.007135106,
-0.0011554006,
-0.0075761853,
-0.019005328,
-0.02407774,
-0.004355658,
-0.010754551,
0.02270261,
-0.030097174,
0.028332857,
0.012849677,
0.030849604,
-0.020678835,
0.016566418,
-0.012006437,
-0.020056134,
-0.009924284,
-0.01015131,
-0.0026853944,
0.0073880777,
-0.013556701,
-0.007699428,
-0.0012332381,
0.0065934868,
-0.016060475,
0.014101564,
-0.013174,
-0.0041967398,
-0.0041221455,
-0.0041286317,
0.011117793,
-0.009839959,
0.034845263,
0.029370692,
-0.035597693,
-0.023156662,
0.0025929625,
-0.00068797014,
-0.023299364,
0.0018437762,
-0.004271334,
-0.011558872,
0.008704829,
-0.018992355,
0.0061102454,
-0.019394515,
-0.0066259187,
-0.00037621468,
-0.017253984,
-0.01246049,
-0.014581562,
0.026931781,
0.008938341,
-0.00048283587,
0.019109111,
0.003470256,
-0.012252923,
-0.015515612,
-0.016877769,
0.017344793,
0.036194447,
-0.006230245,
-0.0067588915,
0.019433433,
0.044938195,
-0.0059740297,
-0.009833474,
-0.020691806,
0.0014610752,
-0.020730726,
0.0037232281,
-0.051113304,
0.0147112915,
0.032328516,
-0.0075632124,
-0.022715583,
-0.0221318,
0.031576086,
-0.01308319,
0.024804223,
0.0019378299,
-0.00067540264,
0.014309131,
-0.0037848493,
0.01359562,
-0.021509102,
0.0035610665,
0.002494044,
0.039204165,
0.02968204,
0.022456124,
0.020665862,
0.022339368,
-0.010728605,
0.0144518325,
0.0003597958,
-0.0019216138,
0.0060324077,
0.02488206,
-0.023091797,
0.002236207,
0.016047502,
-0.028358802,
0.0085945595,
0.0073945643,
0.011409683,
-0.019550191,
-0.016060475,
0.020004243,
0.011792384,
0.04802575,
-0.022235585,
-0.023429094,
-0.016229123,
-0.021444237,
-0.00042770096,
0.004430252,
-0.020354511,
0.013517783,
0.0064151087,
0.0020399916,
0.011565358,
-0.0032189058,
-0.027035566,
-0.013063731,
-0.022585854,
0.018434519,
0.010002121,
0.004329712,
-0.010838875,
-0.018940464,
0.032639865,
0.020237755,
-0.002362693,
-0.023429094,
0.009048612,
-0.040683076,
-0.0009599961,
0.011221576,
-0.010300498,
-0.042369556,
-0.023740444,
0.003914579,
-0.0052832216,
0.025712328,
-0.0031686358,
-0.009431313,
-0.005750247,
0.0030162039,
-0.025530707,
0.025855029,
0.0015729666,
0.004203226,
-0.028332857,
0.005918895,
-0.00044472792,
0.02114586,
-0.011967518,
0.016190205,
0.0024924222,
0.009943743,
-0.0125058945,
0.004722143,
0.024972871,
0.0013832375,
0.0043394417,
0.019978296,
0.0073167267,
-0.018901544,
0.02425936,
-0.007290781,
0.005879976,
0.005228087,
-0.035182558,
-0.032458246,
0.006188083,
-0.007783752,
0.0032497165,
-0.024298279,
-0.025738273,
0.010923198,
0.016190205,
0.032691758,
-0.010086445,
0.011104819,
0.0069469986,
-0.011792384,
-0.008581586,
0.0024486387,
-0.001234049,
0.028203128,
-0.007984832,
0.021664776,
0.004654035,
0.012324274,
0.0043653874,
0.0046086297,
0.014088591,
-0.0040994426,
0.010903739,
-0.022040991,
0.008847532,
-0.006499433,
-0.033262566,
0.0037264712,
0.0024453953,
-0.03225068,
0.013699403,
0.005695112,
-0.0029253934,
0.0433555,
0.015372911,
-0.012681029,
-0.00009886784,
0.0039697136,
0.019653974,
0.028047454,
-0.0024194496,
-0.024311252,
-0.035831206,
-0.01399778,
-0.024505846,
0.017124254,
-0.037569575,
-0.0072648353,
0.020159917,
-0.0035383638,
0.019031273,
0.0050270064,
-0.008626992,
0.0067329453,
-0.011390224,
-0.0066615944,
-0.011176171,
-0.023052879,
-0.0116042765,
0.050153308,
0.00087161805,
0.007245376,
0.0020659375,
-0.009139422,
-0.0021372885,
-0.016306961,
0.0013848592,
0.013530755,
0.0011870222,
0.0020772887,
-0.019290732,
0.009586988,
0.0053091673,
-0.006856188,
0.022949096,
-0.004436739,
-0.01683885,
-0.020510186,
0.011552385,
0.0009883743,
-0.0013881024,
-0.025349086
] |
Wnt7a signals through its receptor Fzd7 to activate the planar-cell-polarity pathway and drive the symmetric expansion of satellite stem cells resulting in enhanced repair of skeletal muscle. In differentiated myofibres, we observed that Wnt7a binding to Fzd7 directly activates the Akt/mTOR growth pathway, thereby inducing myofibre hypertrophy. Notably, the Fzd7 receptor complex was associated with Gα(s) and PI(3)K and these components were required for Wnt7a to activate the Akt/mTOR growth pathway in myotubes. Wnt7a-Fzd7 activation of this | [
-0.021253087,
-0.010041295,
-0.018570147,
-0.008278972,
-0.036614228,
0.008463095,
-0.02943342,
0.0067928336,
0.0020335757,
-0.0066810446,
0.027092425,
0.0067139235,
0.006418011,
0.014966591,
-0.012954388,
-0.008134303,
0.01574254,
-0.0011146034,
-0.010212266,
0.014743013,
0.008561732,
0.009797988,
-0.00009981906,
-0.01083697,
-0.009317953,
0.009554682,
0.013394968,
-0.028512804,
-0.0072991727,
-0.010074173,
0.010317479,
-0.008936554,
-0.0066777566,
-0.018820029,
0.003113656,
0.005612472,
0.008765583,
-0.02484349,
0.0039422107,
-0.010034719,
0.010100476,
0.002222631,
0.005921536,
-0.004639249,
-0.01661055,
-0.015334838,
0.00024433323,
-0.020963749,
0.0013291399,
0.017531166,
0.0024610048,
0.0030084427,
-0.026474297,
0.020371925,
-0.029249297,
-0.020963749,
0.016663156,
0.016400123,
0.0033701134,
-0.007286021,
-0.0012642036,
0.0041460614,
-0.020740172,
0.0014598345,
-0.0007829349,
0.008232941,
-0.01238229,
0.00070196996,
0.007095322,
-0.0020302879,
0.04463674,
0.030196216,
-0.008397336,
-0.01159319,
0.023738751,
-0.0052475133,
-0.028433895,
-0.014282705,
-0.025750956,
0.0069966842,
0.028539108,
-0.0071413526,
-0.011224944,
0.052264705,
0.0077397535,
-0.0039224834,
-0.0056979577,
0.02198958,
-0.0011047396,
0.0063325255,
0.0094955005,
0.0132371485,
0.013394968,
0.00771345,
-0.016913038,
-0.0010332274,
0.0006193611,
0.00003244248,
-0.008594612,
-0.015045501,
-0.013756638,
0.009758533,
-0.00941659,
-0.014940288,
-0.019201428,
0.0133094825,
-0.00036475313,
0.0031481793,
0.031721808,
-0.020792779,
-0.046951436,
0.025409011,
-0.009225891,
-0.030327734,
0.006312798,
-0.004471565,
0.03109053,
0.031064227,
-0.0094955005,
-0.0025925215,
0.013381816,
0.032090057,
0.007923877,
-0.0003807817,
0.029670151,
0.017307587,
0.004481429,
0.02333105,
-0.03282655,
0.0028292513,
0.02034562,
0.0013661289,
0.014782469,
0.015019198,
-0.03195854,
0.022673465,
-0.014466829,
-0.010014991,
-0.031406168,
-0.053080108,
-0.009705927,
0.008949706,
-0.013848701,
-0.0055861687,
-0.014992895,
-0.003153111,
0.030669676,
-0.013546213,
0.023436261,
-0.011764162,
0.016913038,
-0.015952967,
0.00452746,
-0.0008729416,
-0.014624649,
0.01613709,
0.0021618046,
0.011974589,
-0.018478086,
-0.018228203,
0.007128201,
-0.0013990081,
0.016807824,
-0.010988214,
0.018241355,
0.011777313,
0.013151662,
0.0051423,
0.0043005934,
-0.013953914,
-0.0027503413,
0.021976428,
-0.023620386,
0.013638274,
-0.01099479,
0.004931873,
-0.017018251,
0.003238597,
-0.037613753,
-0.0017935579,
-0.028591713,
0.01629491,
0.016847279,
-0.0075819334,
-0.0027914403,
-0.023291593,
0.018649057,
-0.029696453,
-0.0059281117,
-0.026540054,
0.015887208,
0.017991474,
-0.01159319,
-0.009396863,
-0.6224419,
-0.025882471,
0.01788626,
0.0041493494,
0.009035192,
0.019411854,
-0.0022785254,
-0.0076476918,
-0.0039783777,
0.016899886,
-0.027118728,
0.023909722,
0.001752459,
-0.0300647,
-0.0155978715,
0.004412383,
-0.023541475,
-0.041085795,
0.028933657,
0.016531639,
-0.01692619,
0.0045373235,
-0.0070427153,
0.01254011,
0.016742066,
0.0144536765,
0.019451309,
-0.01629491,
0.0032862716,
0.03266873,
-0.024896096,
0.032221574,
0.008443367,
-0.009922929,
0.04437371,
-0.0018017777,
-0.016715763,
0.017504863,
0.00010105203,
0.016834129,
-0.013368664,
0.009475772,
-0.002178244,
-0.008798462,
-0.029775364,
0.030012093,
0.012283653,
0.002766781,
-0.011100003,
-0.011797041,
0.02974906,
0.0103306305,
-0.031353563,
0.006122099,
0.027855221,
0.015966117,
0.016899886,
0.0072136866,
-0.0050403746,
0.021134721,
0.004435398,
0.051686034,
-0.005086405,
-0.028539108,
0.0053527267,
0.0009699351,
-0.03124835,
0.0053625903,
0.021936974,
-0.0058097467,
0.0076937224,
0.023857115,
0.010185963,
0.016479032,
0.019727493,
0.03979693,
-0.022647163,
-0.0013480454,
-0.00894313,
0.022804983,
-0.00070772384,
-0.0038698767,
-0.005651927,
0.010291176,
0.021950124,
0.024120148,
-0.035614703,
0.037534844,
0.016439578,
0.028197164,
0.0033602498,
-0.021371452,
0.00056675443,
-0.04802987,
-0.012533534,
0.015689934,
0.007943604,
0.029249297,
-0.01313851,
-0.021489816,
-0.008634066,
0.014966591,
0.025501072,
-0.0075687817,
0.013677728,
0.0063489648,
-0.040217783,
0.0031662628,
0.019530218,
-0.033826075,
-0.0042710025,
0.014006521,
-0.0051949066,
-0.0008844493,
-0.00575714,
-0.02429112,
0.017662682,
0.0130596,
0.0102582965,
-0.017675834,
0.019161971,
-0.009962385,
0.030748587,
0.015781995,
0.03590404,
0.0031448912,
0.013822397,
0.00043441585,
0.00055154786,
-0.01810984,
-0.01099479,
-0.009883475,
0.016978797,
-0.034325838,
0.0072991727,
-0.0100939,
-0.005418485,
0.0123165315,
0.029775364,
-0.029301904,
-0.041164704,
-0.004935161,
0.021923821,
-0.04184859,
0.0030396779,
-0.02050344,
-0.029170386,
0.009186436,
0.003161331,
0.00933768,
-0.018649057,
-0.012809719,
-0.015479507,
0.009541531,
0.016123937,
-0.012829446,
0.004520884,
-0.022831285,
-0.004234835,
-0.034010198,
-0.01810984,
0.007923877,
-0.008956282,
0.0057407008,
0.0031432472,
-0.016702611,
-0.022134248,
-0.0006662139,
-0.014361615,
-0.02104266,
-0.007673995,
-0.013440999,
-0.015124411,
0.021121569,
-0.0005490819,
0.018609602,
0.0057505644,
0.009199588,
-0.00028604866,
-0.009232467,
-0.015229625,
-0.023738751,
-0.0022078352,
-0.0029163812,
0.034036502,
0.012033771,
0.00063908857,
0.0034819026,
-0.009390287,
0.016373819,
-0.023620386,
0.022581404,
-0.003965226,
0.018478086,
-0.015716236,
-0.029880576,
0.032616124,
0.0030199504,
0.0131582385,
0.02531695,
0.0069966842,
-0.02864432,
0.023068016,
0.007785784,
0.024001785,
-0.006779682,
0.010659423,
-0.03345783,
0.022844438,
-0.0031268077,
-0.010231993,
0.0011885815,
-0.00038674107,
-0.001011856,
0.008811614,
-0.0010208978,
-0.012040347,
-0.014940288,
-0.014887682,
0.0013842124,
-0.010324055,
-0.006279919,
-0.0028933657,
-0.0059281117,
0.00530012,
0.03219527,
-0.015203321,
0.03916565,
0.011441946,
-0.008009362,
0.012355987,
0.017031403,
0.018004626,
0.017386498,
0.014282705,
0.004875979,
0.0031366714,
0.0001867947,
0.028749533,
-0.008923403,
0.021121569,
0.009087798,
0.0013217421,
0.0073846583,
-0.008265819,
-0.019293489,
0.019346096,
0.010889577,
0.0010669286,
0.021410907,
0.00460637,
0.02586932,
0.008857644,
0.015729388,
-0.006740227,
-0.019188276,
-0.010718605,
0.003702193,
0.031669203,
0.034983423,
0.030432947,
0.017623227,
0.013822397,
0.007851542,
0.005027223,
0.0137697905,
-0.010304327,
0.0018346569,
-0.011389339,
-0.0046096575,
0.0077002984,
0.015729388,
0.018688513,
-0.04153295,
0.016097635,
-0.0069243503,
0.021266239,
0.011744434,
0.0037811028,
0.027644794,
0.013677728,
-0.03711399,
0.032642424,
0.0052277856,
-0.018372873,
0.01060024,
-0.03277394,
-0.0019102789,
0.0012650255,
-0.023870267,
-0.016413275,
0.002485664,
-0.00052688847,
-0.0122376215,
-0.01859645,
-0.006779682,
0.017491711,
-0.010370086,
0.033641953,
-0.010370086,
-0.008252668,
-0.006319374,
-0.019267185,
-0.01194171,
0.049897406,
-0.00937056,
0.00051291485,
0.00397509,
-0.0143747665,
-0.025382709,
-0.0067533785,
-0.0050962693,
0.00016665622,
-0.0014475049,
-0.012829446,
0.0017113601,
0.013145086,
-0.0136119705,
0.043137453,
0.005178467,
-0.003856725,
-0.022975953,
-0.014230099,
-0.020306166,
0.024080694,
0.0490557,
0.0060168854,
0.0005215456,
-0.0064443145,
0.020976901,
-0.011599766,
-0.013822397,
0.0070295637,
-0.014282705,
-0.0037811028,
-0.0053297114,
-0.0025399148,
-0.00066374795,
-0.007864694,
0.02761849,
0.0031646187,
-0.030643374,
-0.02659266,
-0.02034562,
-0.0024675806,
0.003813982,
0.014111734,
0.04184859,
0.02943342,
0.023107471,
-0.0012222826,
0.043453094,
-0.00763454,
-0.05005523,
0.011954861,
0.0102582965,
-0.00053140934,
0.006592271,
0.0017179359,
-0.028144557,
-0.013000418,
0.009870322,
0.02034562,
0.013493606,
0.013638274,
-0.0006316908,
0.02421221,
0.012684778,
-0.0026549918,
0.011152609,
0.001987545,
-0.0042874417,
-0.002921313,
-0.01309248,
0.016676309,
-0.020371925,
-0.011270975,
-0.0046589766,
0.0042282594,
-0.0047707655,
-0.0056913816,
-0.015203321,
0.0016094347,
-0.019240882,
-0.012520382,
0.00802909,
0.018228203,
-0.0037219205,
0.008134303,
-0.0023262003,
-0.001597927,
0.0023081168,
-0.003419432,
0.0011072055,
-0.006161554,
-0.00545794,
-0.0292756,
-0.0010981638,
0.01083697,
0.03821873,
0.016110787,
-0.001984257,
-0.014269554,
0.036009252,
0.0032484606,
-0.019161971,
-0.013743487,
-0.022423584,
0.0012214606,
0.0034062804,
0.02294965,
-0.0012165287,
0.0025185433,
-0.010481874,
0.040454514,
-0.011014517,
0.033641953,
-0.012914932,
0.0004792137,
0.018938394,
0.02880214,
0.0047641895,
0.01613709,
0.022344675,
-0.02008259,
-0.017583773,
-0.013940762,
-0.0013669509,
-0.002340996,
-0.020766474,
0.026789935,
0.0067533785,
-0.021108419,
-0.025356404,
-0.01004787,
0.0039487868,
0.0059412634,
0.00444855,
0.023396807,
0.026829392,
0.0140722785,
-0.008193485,
0.02301541,
-0.013743487,
-0.001012678,
-0.031353563,
0.014808772,
-0.009548107,
-0.02824977,
0.011303854,
0.004241411,
-0.011501129,
-0.019477611,
-0.008482822,
-0.007509599,
0.0411384,
0.009193012,
-0.0107909385,
-0.007923877,
0.006181281,
-0.025658892,
0.0016135445,
-0.0026254007,
-0.0057735797,
-0.023409959,
0.022686617,
0.019293489,
-0.016544791,
0.016623702,
-0.03298437,
-0.00854858,
0.023265291,
0.014677255,
-0.003583828,
0.0073057483,
0.018714815,
0.009594138,
-0.017373346,
-0.02183176,
-0.050791718,
0.01605818,
-0.004721447,
0.0071545043,
0.025251191,
0.026645267,
0.02990688,
0.001791914,
0.031432472,
-0.0033618936,
-0.012816295,
-0.040138874,
0.02184491,
-0.030354036,
0.045872997,
0.021029508,
-0.00575714,
0.046556886,
-0.01938555,
0.031222045,
0.021950124,
-0.01566363,
0.0073780827,
0.03124835,
-0.031300955,
-0.0072334143,
0.013099056,
0.004011257,
-0.0068257125,
-0.04266399,
0.0023640112,
0.013598819,
0.011586615,
-0.0064508906,
0.009252194,
0.0074109617,
-0.014124885,
0.05255404,
-0.0026254007,
-0.001906991,
0.008193485,
-0.02049029,
0.010317479,
0.011132882,
0.0017836943,
-0.0030281702,
-0.0033602498,
0.005842626,
-0.005214634,
0.0051554516,
0.0061977208,
-0.0012831091,
-0.030012093,
-0.025106523,
-0.026724178,
-0.02974906,
-0.036772046,
-0.011336733,
-0.037534844,
-0.013927611,
0.0069901086,
-0.038166124,
0.0073846583,
0.019332943,
-0.015308535,
0.031274654,
-0.015624175,
0.023515172,
-0.0102846,
0.006085932,
0.022252612,
0.018491236,
-0.030012093,
-0.020634959,
-0.02287074,
0.006279919,
0.034010198,
-0.0057472764,
-0.010389813,
-0.036351193,
0.0042315475,
0.026329627,
-0.033563044,
-0.027092425,
0.014756165,
0.008009362,
0.028986264,
0.008522277,
0.0041131824,
-0.031669203,
0.018175596,
-0.0053658783,
-0.0034457354,
-0.0012526958,
-0.003269832,
-0.022936499,
0.013316058,
-0.010291176,
0.02388342,
-0.004560339,
-0.009653321,
-0.010843545,
0.0018149294,
-0.0006041545,
0.005303408,
0.003161331,
0.028065648,
-0.01575569,
0.017781047,
0.022292068,
0.023699295,
0.0084302155,
-0.018635906,
0.006049765,
0.042111624,
-0.0038106942,
-0.0034029926,
0.007128201,
-0.0021075539,
-0.009002313,
0.00925877,
-0.010843545,
-0.016031876,
-0.031853326,
-0.0084302155,
0.024264816,
0.0050962693,
0.020779626,
0.010606816,
-0.036009252,
-0.005369166,
-0.025935078,
-0.023620386,
0.0021174175,
-0.05173864,
-0.017149767,
-0.00019563097,
0.030248823,
0.011948286,
-0.0016480677,
-0.0029278889,
-0.011461673,
0.032379393,
-0.01992477,
0.011363036,
0.009508652,
0.008614339,
-0.024343727,
0.0102582965,
-0.009633592,
-0.032484606,
0.0078975735,
-0.015255928,
-0.03030143,
0.017268132,
0.012691354,
0.02200273,
0.0007142997,
-0.008278972,
0.03577252,
0.0017984898,
0.012375714,
-0.006105659,
-0.0024675806,
-0.0048430995,
0.009449469,
-0.00011589903,
0.0038863162,
-0.0026582798,
-0.0055532893,
0.0023475718,
-0.016321212,
0.020753324,
-0.014348463,
-0.030564463,
-0.010271449,
0.012231046,
-0.0072136866,
-0.0049581765,
-0.023146925,
-0.020135194,
-0.010501603,
0.002069743,
0.006161554,
-0.018556995,
-0.01810984,
0.0046721282,
-0.004428822,
0.0065791192,
-0.03616707,
-0.014269554,
-0.0049417373,
-0.03506233,
-0.021134721,
-0.010370086,
-0.015453204,
0.023712447,
0.0013685948,
-0.0049647526,
-0.012559838,
-0.0019250746,
-0.050344564,
-0.019346096,
-0.010218842,
-0.0096467445,
-0.0006152512,
0.01575569,
-0.024935551,
0.0057045333,
-0.012908356,
-0.0031629747,
-0.0010965199,
-0.017662682,
0.010948759,
-0.017820502,
0.01519017,
-0.0075030234,
-0.04137513,
-0.036640532,
0.003735072,
-0.009653321,
0.0037186325,
0.014650952,
-0.025093371,
0.021371452,
-0.009627017,
0.038245033,
0.013743487,
0.018070385,
0.021476664,
-0.04542584,
-0.0006423765,
0.007746329,
0.001709716,
-0.013940762,
0.012362562,
-0.0027733569,
0.007989635,
0.01479562,
0.0056157596,
-0.039665412,
-0.008726128,
0.0017393073,
0.05292229,
-0.0056190477,
0.006270055,
0.017294437,
0.024475243,
-0.009146981,
-0.010935607,
0.002410042,
0.0026254007,
-0.0074898717,
0.014729862,
-0.00069991505,
-0.013434423,
0.006536376,
-0.0101070525,
-0.020358773,
-0.0039060437,
-0.0019793252,
-0.0055467137,
-0.0074635684,
0.004783917,
-0.018543843,
-0.022555102,
-0.019346096,
0.0059840064,
-0.00466884,
-0.009035192,
-0.011270975,
-0.00042167518,
0.0077792085,
-0.03537797,
-0.00026960907,
-0.016715763,
0.008522277,
0.009830868,
-0.005684806,
-0.012092954,
0.021936974,
0.20832233,
-0.014545739,
-0.0066547412,
0.0041559255,
0.013664577,
0.005842626,
0.02872323,
0.0038665887,
-0.014282705,
-0.018399175,
-0.0012115969,
0.015952967,
0.009239043,
-0.0044649895,
0.0213583,
-0.005872217,
-0.011566887,
-0.010902728,
-0.016913038,
-0.0077200257,
0.011612918,
-0.028144557,
-0.0024330574,
0.003623283,
0.0077923597,
-0.0077200257,
-0.056973003,
-0.016676309,
0.030985316,
0.017202374,
-0.020135194,
-0.007437265,
-0.016163394,
0.016400123,
0.0033865531,
-0.003544373,
-0.028828444,
-0.0016932766,
0.023238987,
-0.0051127085,
0.019648584,
0.0016867007,
-0.015203321,
0.018136142,
0.009028616,
0.00941659,
-0.0028473348,
-0.0078186635,
-0.004280866,
0.03685096,
-0.02809195,
-0.008292123,
0.021963276,
0.0269083,
-0.029301904,
-0.016834129,
0.0139933685,
0.009081223,
-0.0010973418,
0.034325838,
-0.038297642,
-0.0006789546,
-0.01582145,
0.039902143,
-0.031984843,
0.014585193,
-0.005526986,
0.006316086,
0.027197639,
-0.014414222,
-0.0016406699,
-0.001597105,
-0.007923877,
0.0058163228,
-0.00846967,
-0.023528324,
0.03348413,
0.009659896,
0.02903887,
0.030485554,
0.024014935,
-0.002766781,
-0.0074964473,
0.013322634,
0.008561732,
-0.019806404,
0.0068848953,
0.014098582,
0.0025267631,
0.004481429,
0.0137697905,
-0.008134303,
-0.004708295,
-0.011422219,
-0.005839338,
-0.01321742,
-0.010731757,
-0.0040309844,
-0.0071808076,
-0.0053264233,
-0.017018251,
0.06381187,
-0.007200535,
-0.0008655438,
-0.013875004,
-0.0001381952,
0.0069440776,
0.006454178,
-0.034352142,
-0.0136119705,
0.014006521,
-0.04500499,
-0.0016587534,
-0.006506785,
-0.019556522,
0.0026451282,
0.02104266,
0.0029163812,
0.05016044,
-0.019753797,
-0.015163867,
-0.026803087,
0.0011244671,
0.026763633,
-0.010074173,
0.008561732,
-0.023449413,
-0.0115537355,
0.006066204,
-0.023633538,
0.009534955,
-0.004238123,
-0.008094848,
0.0011548804,
0.00006288139,
-0.011652373,
-0.013112207,
-0.019332943,
0.0038830284,
0.031537686,
-0.011461673,
-0.022989105,
0.024909249,
0.018149294,
0.01337524,
-0.002607317,
0.027329154,
0.025737803,
-0.0062141605,
-0.032090057,
-0.01455889,
0.006240464,
0.007627964,
-0.004330185,
0.015387445,
0.016242303,
-0.023317898,
-0.020687565,
0.00272897,
0.0015675138,
-0.02049029,
0.014966591,
0.0049647526,
-0.023133773,
-0.016110787,
-0.003314219,
-0.16434318,
0.025224889,
0.018714815,
-0.031116834,
0.023423111,
-0.0005725083,
0.016715763,
-0.011875951,
-0.012605868,
0.021161025,
0.03940238,
0.000050423267,
-0.020214105,
-0.0027602052,
-0.015255928,
0.022831285,
-0.0083513055,
0.032695033,
0.004201956,
0.026868846,
0.02435688,
-0.011777313,
0.003353674,
-0.013039873,
-0.0014943576,
-0.005411909,
-0.011921982,
-0.017189223,
-0.013651425,
-0.013401544,
0.00066046003,
0.014111734,
0.04203271,
-0.024304273,
0.013743487,
-0.0009181504,
-0.010133356,
-0.010120204,
-0.012993842,
0.030012093,
0.030275127,
0.016742066,
0.008647218,
-0.014243251,
-0.023068016,
0.014611497,
0.007364931,
-0.0016045028,
0.019885313,
-0.031774417,
0.009830868,
-0.0036528741,
0.016571095,
0.022739224,
0.031169439,
0.03030143,
0.026513752,
-0.007055867,
-0.014848227,
-0.01826766,
0.014019672,
0.016913038,
0.02864432,
-0.013572516,
-0.0019349384,
-0.02555368,
-0.019135669,
0.0026138928,
-0.04463674,
0.009521804,
-0.031537686,
-0.010685726,
0.0028506229,
-0.028170861,
0.021450361,
0.015808297,
0.0046951436,
-0.003426008,
-0.00036208172,
-0.0014590125,
-0.023541475,
0.028170861,
-0.017386498,
-0.025698349,
-0.020976901,
0.014230099,
0.010324055,
0.02088484,
0.0030067987,
0.00049688626,
0.01629491,
-0.017162919,
0.015847754,
-0.015584719,
0.0403493,
0.011363036,
-0.0039224834,
0.0070624426,
-0.012849174,
0.004313745,
0.037087686,
-0.0039159073,
-0.009633592,
0.0072991727,
0.02659266,
0.016834129,
-0.003504918,
0.04279551,
0.025777258,
0.009896626,
-0.0057045333,
0.013072752,
0.0041000308,
0.0058524897,
-0.010034719,
0.015571568,
0.011520856,
0.0030659812,
0.012033771,
-0.017333891,
0.061128926,
0.014979743,
-0.01337524,
0.026645267,
-0.008061969,
-0.027750008,
-0.12404648,
-0.016663156,
0.0068717436,
0.047267076,
-0.0071742316,
0.0010217198,
0.012007467,
0.015703084,
-0.015255928,
0.035246454,
-0.033641953,
-0.03750854,
0.0065791192,
-0.006316086,
0.0009477417,
-0.01835972,
0.027539581,
0.01004787,
-0.033378918,
0.029249297,
-0.0082723955,
0.004777341,
-0.011803617,
-0.009745382,
-0.0057538524,
0.012217894,
-0.04003366,
0.03616707,
0.010310903,
0.000009150937,
0.019030455,
-0.018898938,
0.038429156,
-0.012362562,
-0.031143136,
-0.020582352,
0.009916353,
-0.008680097,
0.016334364,
-0.012895205,
0.029301904,
0.0058919447,
-0.006204297,
-0.017715288,
-0.00763454,
0.0039454987,
-0.026250718,
0.010448996,
0.017294437,
-0.016413275,
-0.042427264,
-0.012875478,
-0.010981638,
0.0067731063,
0.015847754,
0.001207487,
0.009705927,
0.014861379,
0.0051324363,
0.0035608127,
-0.0116721,
0.00016953314,
0.0011236451,
-0.017110312,
0.032563515,
-0.001906991,
-0.021121569,
-0.03522015,
0.030354036,
-0.008759007,
0.007884421,
0.013223996,
0.0010085681,
0.0061977208,
-0.014598345,
-0.005763716,
-0.009771685,
-0.016018724,
0.014466829,
-0.007706874,
-0.013322634,
-0.023922874,
0.013289755,
-0.016794672,
0.033957593,
-0.0014894258,
0.0026286885,
-0.023936026,
0.01309248,
-0.009153557,
-0.019530218,
0.038797405,
-0.0035706763,
-0.0054415003,
-0.016728915,
0.004011257,
-0.006648165,
-0.0013718827,
-0.0023738751,
0.014927137,
-0.03450996,
-0.01575569,
-0.05023935,
0.007766057,
0.018846331,
0.020398227,
-0.0035969797,
-0.01922773,
0.013782942,
-0.0067928336,
0.0074569928,
0.010481874,
-0.009350832,
-0.0035114938,
0.0037515117,
-0.028907353,
-0.016202848,
-0.034089107,
0.0371929,
-0.035036027,
0.004701719,
0.029775364,
-0.007706874,
0.003925771,
0.012217894,
-0.00091404055,
-0.00010223362,
-0.010567361,
-0.048477028,
0.003151467,
-0.0005083939,
0.0013579092,
-0.0059872945,
-0.051081058,
-0.025777258,
0.00062881387,
-0.001287219,
-0.025895623,
-0.029301904,
0.011704979,
0.006917774,
0.027855221,
-0.030748587,
-0.01747856,
0.012060074,
-0.0007529327,
0.0034621751,
0.011455098,
-0.016991947,
-0.0069901086,
-0.00039865976,
-0.010034719,
0.019806404,
0.020108892,
0.011297278,
-0.018793726,
-0.022173703,
-0.0076082367,
-0.015611023,
-0.01883318,
0.017294437,
-0.0300647,
0.000034035063,
-0.0013595531,
0.013717184,
0.0064015714,
-0.016150242,
-0.030169914,
-0.006191145,
0.0011483046,
0.008344729,
-0.029170386,
-0.033563044,
0.008147455,
0.03348413,
0.0053165597,
0.00043112793,
0.021226782,
-0.011599766,
-0.008877372,
-0.01645273,
0.012993842,
0.022883892,
-0.0025152555,
-0.029222993,
0.0114024915,
0.01182992,
0.0038665887,
-0.01605818,
0.0043532,
-0.00009725038,
0.006108947,
-0.010626543,
0.013276603,
0.0060530524,
0.02167394,
-0.024501547,
0.04603082,
-0.011691827,
0.0064114355,
-0.004793781,
0.014348463,
0.015584719,
-0.004908858,
0.020963749,
-0.0024511411,
-0.006046477,
0.006184569,
-0.03298437,
-0.031932235,
-0.02050344,
-0.02793413,
0.01332921,
0.016636852,
-0.0032155814,
0.00082896574,
0.005918248,
0.01285575,
0.021608181,
-0.031695507,
-0.0069638053,
0.012033771,
0.01970119,
-0.006270055,
-0.0049252976,
-0.01883318,
0.0026533478,
0.005224498,
0.04058603,
-0.014940288,
0.008371033,
-0.018609602,
0.019398702,
0.002257154,
-0.007358355,
-0.017031403,
-0.004586642,
-0.0055993204,
0.0048463875,
0.03124835,
-0.033589344,
0.09043083,
-0.002375519,
-0.011849647,
-0.025527377,
-0.010159659,
0.018412327,
0.0037153447,
0.011619493,
-0.025356404,
-0.0371666,
-0.0057472764,
-0.02168709,
0.028775837,
-0.008068545,
-0.012204743,
0.0117838895,
0.007937028,
0.0044649895,
0.004284154,
-0.0060793557,
0.009719078,
-0.0077002984,
-0.0053198473,
0.022107944,
-0.021174176,
-0.0053297114,
0.022778679,
-0.001556828,
0.0077200257,
-0.022305219,
-0.010817242,
0.0025843016,
-0.032563515,
0.0005692204,
-0.0025958093,
-0.031300955,
-0.026066594,
-0.03845546,
0.0019645295,
0.011639222,
-0.00003308465,
0.016031876,
-0.0037153447,
-0.01471671,
0.00056182256,
-0.019346096,
0.01993792,
0.0063719805,
-0.04208532
] |
A new technique has been developed for the facile location of pseudouridylate (psi) residues in any RNA molecule. The method uses two known modification procedures which in combination uniquely identify U residues which have been converted into psi. The first procedure involves reaction of all U-like and G-like residues with N-cyclohexyl-N'-beta-(4-methylmorpholinium)ethylcarbodiimide p-tosylate (CMC), followed by alkaline removal of all CMC groups except those linked to the N3 of psi. This stops reverse transcription, resulting in a gel band which identifies the U residue. | [
-0.018873204,
0.0023332066,
-0.018624144,
-0.007278083,
-0.014459309,
0.012930358,
-0.008502627,
-0.011131592,
-0.010031578,
-0.012238525,
0.034674667,
0.01697758,
-0.0092843985,
0.020409072,
-0.011774997,
-0.026040593,
0.01689456,
0.0007138851,
0.011505182,
-0.00043434137,
-0.01689456,
-0.0005270902,
-0.017780107,
-0.024463214,
-0.0014398773,
0.020118503,
0.014957429,
-0.0090007465,
-0.016783867,
-0.009900129,
-0.0029748818,
-0.015247999,
-0.017627904,
-0.011961792,
-0.017378844,
-0.01242532,
0.0151373055,
-0.010730329,
0.011027818,
-0.012605197,
0.020478256,
0.019620383,
-0.0043377928,
0.002174085,
-0.0026670161,
-0.009996986,
-0.0042686095,
-0.005960141,
-0.014653022,
0.021336129,
0.010363658,
0.02042291,
-0.015635425,
-0.008018344,
-0.013636027,
-0.011975628,
0.0020149634,
0.027922379,
-0.011290714,
-0.013483824,
-0.0059013353,
-0.009948558,
-0.029997878,
0.014307106,
0.010591962,
0.0058425292,
0.005161074,
0.014666859,
0.002004586,
-0.025044354,
-0.0075824894,
0.012529095,
-0.011249204,
-0.01805684,
0.04430498,
-0.009132195,
-0.019620383,
-0.0068733604,
0.01250834,
0.013968107,
0.030634364,
-0.02480913,
-0.0009659718,
0.0066450555,
0.017544884,
-0.010176863,
0.002364339,
0.03378912,
-0.0049223914,
-0.024089623,
0.02240155,
0.06934933,
0.014625349,
0.011007062,
-0.021142416,
0.013739803,
-0.01321401,
0.018444266,
-0.007091288,
-0.029887185,
-0.006444424,
0.0056003877,
0.006658892,
-0.008225894,
-0.0062922207,
0.0018921632,
0.0007566923,
-0.031492237,
0.014210249,
0.00426515,
-0.0057837237,
0.03459165,
-0.000274355,
-0.029693471,
0.019827932,
-0.0012721078,
0.03168595,
-0.0010092113,
-0.005268308,
0.00020992807,
0.01639644,
0.004240936,
0.01801533,
-0.010965552,
0.03984958,
0.009962395,
-0.010702656,
-0.018610306,
-0.02422799,
-0.0016716414,
0.027078342,
-0.0023505024,
0.01813986,
0.026248142,
-0.0059290086,
0.012639788,
-0.021599025,
-0.015801465,
-0.017780107,
-0.03326333,
0.019191446,
0.018112186,
-0.012480667,
0.011698895,
0.029223025,
0.0124945035,
0.019814096,
0.012916521,
-0.013310866,
-0.015220325,
0.00625417,
-0.030108571,
0.011304551,
0.0090422565,
-0.008724013,
0.011249204,
-0.0038638872,
0.029859511,
-0.034702342,
-0.028475845,
-0.019274466,
0.0011467132,
-0.0021308456,
0.0045038327,
0.00451421,
0.008191302,
0.0044588633,
0.010467432,
-0.014376289,
-0.010972471,
0.0038673463,
-0.0045072916,
-0.041122552,
0.012065567,
0.0046318215,
0.0009140843,
0.0053236545,
0.012446075,
0.0008890054,
-0.011166184,
0.01259136,
-0.009782518,
0.025334923,
0.006133099,
-0.011899527,
0.00021998126,
0.0055069905,
-0.007430286,
-0.006651974,
-0.024158807,
0.001793577,
0.0027569544,
0.00025316761,
-0.01755872,
-0.6468915,
-0.05487619,
0.0012712431,
-0.006025865,
0.012888848,
0.045827016,
0.019565037,
-0.0008276052,
-0.006672729,
0.047376722,
0.00443119,
0.0039399886,
-0.009007665,
-0.005437807,
-0.013912761,
-0.026621733,
0.0013559926,
-0.010834104,
0.047708802,
-0.019731076,
-0.03312496,
-0.0017434191,
-0.0096510695,
0.0031564878,
0.022194002,
0.018292064,
0.025251903,
-0.020851845,
-0.0071397163,
0.02418648,
-0.016673174,
0.030495998,
-0.018956224,
-0.0028278672,
0.055512678,
0.0014078801,
-0.004832453,
0.006205742,
0.014265596,
-0.007278083,
-0.0055069905,
-0.022027962,
0.014085719,
-0.00016301314,
-0.013919679,
0.019993972,
0.010785676,
-0.01689456,
0.010557371,
-0.010460515,
-0.0018938928,
0.002518272,
-0.0058459886,
0.0003634285,
0.020685805,
0.0055104494,
0.008246649,
-0.019191446,
0.027963888,
-0.0024283337,
-0.002770791,
0.011394489,
0.016770031,
-0.032571495,
-0.011512101,
0.009388173,
-0.035062093,
0.0036390414,
0.022968855,
0.0011423891,
0.01714362,
0.034065854,
-0.0043827617,
0.0033899816,
-0.020990212,
0.023300935,
0.016216565,
0.0049431464,
0.012764318,
0.009035339,
0.00060448906,
0.010169945,
-0.02725822,
0.011705814,
0.029167678,
-0.002696419,
-0.03196268,
0.0103013925,
0.008551056,
-0.0031357328,
-0.0018437349,
0.017959984,
-0.010564289,
-0.023051875,
-0.019191446,
0.010432841,
-0.0049223914,
-0.0032343192,
0.02472611,
-0.0008890054,
-0.03442561,
0.0033640377,
-0.010730329,
0.013020297,
0.018734837,
-0.0017174754,
-0.02406195,
-0.0018990815,
0.04286597,
-0.014265596,
0.0019596168,
-0.029914858,
-0.002705067,
-0.030412978,
0.018790184,
-0.027811686,
0.02323175,
0.020644296,
-0.011705814,
-0.055512678,
0.002803653,
-0.00043023363,
-0.0023505024,
0.0071812263,
0.0062818434,
0.01826439,
0.045190528,
-0.028558865,
0.006568954,
0.0018039545,
0.0024611957,
-0.021682044,
0.010958634,
-0.0069356253,
0.006482475,
-0.010294475,
0.012771237,
0.009941639,
0.013518416,
-0.026483366,
-0.02539027,
-0.0073126745,
-0.007285001,
-0.00016528321,
-0.0051057274,
-0.027825521,
-0.027036833,
0.009478112,
0.010965552,
-0.012888848,
0.027853195,
-0.0017183401,
0.0025891848,
0.034979075,
-0.0044242716,
-0.0065724133,
-0.03843824,
-0.011795752,
-0.015621589,
0.0027361994,
-0.012024057,
0.015773792,
-0.005686867,
0.011740405,
-0.01921912,
-0.014694532,
0.011934118,
-0.0019734534,
-0.018568797,
-0.025376434,
0.011304551,
0.0055485005,
-0.019468179,
0.0019440507,
0.010612718,
0.039628193,
-0.019993972,
0.015344855,
-0.019910952,
-0.002634154,
0.0028278672,
-0.0048601264,
-0.013684456,
0.0005391973,
-0.011207694,
0.008329669,
0.009851702,
0.023771381,
0.02439403,
0.029472085,
-0.0029662338,
0.0062645474,
-0.0056176838,
0.013248601,
0.013981944,
-0.005375542,
0.022512244,
-0.015497059,
0.0007376669,
0.037054572,
0.011007062,
-0.007997589,
0.013428478,
-0.030994117,
0.020146176,
-0.03445328,
0.014058046,
-0.034038182,
0.046214443,
0.021654371,
-0.01697758,
-0.013850496,
-0.018485777,
-0.007783121,
-0.011615875,
0.012439157,
0.008398852,
0.0100177415,
0.0075271428,
-0.0042893644,
0.0086755855,
0.003222212,
0.03376145,
-0.00219484,
-0.0151373055,
0.0019215661,
0.008011426,
-0.009422765,
0.014016536,
-0.00043888154,
-0.0003046227,
0.019786423,
-0.0046006893,
0.015151142,
0.013020297,
0.021723555,
0.0103844125,
-0.009540376,
0.035338826,
0.0036667148,
-0.014348616,
0.0050123297,
0.0010386142,
-0.0035093226,
0.031907335,
0.008931563,
0.042229485,
0.013788231,
-0.0031426512,
0.019412832,
-0.013096398,
0.0014044209,
-0.025168883,
0.015469385,
0.0026203173,
-0.00028862405,
0.034176547,
0.019191446,
0.024670763,
0.0111938575,
0.005161074,
-0.0009270562,
0.00086781796,
0.020243032,
-0.0069183297,
0.014722206,
0.010688819,
-0.014134147,
-0.040956512,
-0.0025355679,
-0.015317182,
-0.01205173,
0.006783422,
0.004410435,
0.01697758,
-0.008793197,
0.009263643,
0.0022553755,
0.013622191,
-0.01263287,
-0.037967794,
-0.013276274,
0.02543178,
0.011961792,
-0.025570147,
-0.019980136,
-0.011941037,
0.0047528925,
-0.0027517655,
0.010232209,
-0.006693484,
0.015012776,
-0.009782518,
0.029610451,
-0.030385304,
-0.021419149,
0.028046908,
-0.022747468,
0.027396586,
0.0046906276,
-0.0057456726,
0.011013981,
-0.0004838507,
-0.0051956656,
0.049645934,
-0.0014606323,
0.00034526788,
0.0021792739,
0.0064098323,
-0.0093259085,
-0.020436745,
0.0024335224,
0.005884039,
0.014666859,
0.009381255,
-0.012390728,
-0.001652616,
-0.004956983,
0.026953813,
-0.003753194,
-0.013892006,
-0.011083164,
0.0037704897,
-0.0064720972,
0.0011536315,
0.027355075,
0.005399756,
0.00054568326,
0.021336129,
0.012356137,
-0.013919679,
-0.043253396,
0.010806431,
-0.004448486,
-0.014058046,
0.031990357,
0.0072919196,
-0.009118359,
0.0070221047,
0.008039099,
0.023951257,
-0.03077273,
-0.0015756496,
0.017946146,
0.019814096,
-0.0066035455,
0.0016206187,
0.012639788,
-0.008378097,
0.007962997,
0.037082247,
0.010979389,
-0.0026531795,
-0.010557371,
0.001321401,
-0.01751721,
0.001259136,
0.012501421,
-0.0057214587,
-0.020353725,
0.032156397,
0.0125360135,
0.006607005,
-0.018817857,
0.008509546,
0.0062437924,
0.01826439,
0.007340348,
0.008910809,
-0.0040852735,
-0.0002756522,
0.011505182,
0.001731312,
-0.01573228,
0.02659406,
-0.023079548,
-0.008689422,
-0.012542931,
0.021848084,
0.021654371,
0.0021343047,
-0.010135353,
-0.009962395,
-0.0036217456,
-0.0019648056,
-0.018029166,
0.0033017728,
-0.017946146,
-0.01346307,
-0.016507134,
0.011152348,
-0.0063060573,
-0.026635569,
-0.024989007,
0.00443119,
-0.021308456,
-0.021017885,
0.017821617,
0.016936071,
0.029167678,
0.0183059,
-0.0011795752,
0.0084749535,
0.018153697,
-0.014154903,
-0.01333854,
0.007845386,
-0.032903574,
0.009049175,
0.019731076,
0.0072019813,
-0.0063717817,
-0.014888246,
0.005036544,
-0.00009582967,
-0.00306482,
0.011138511,
0.010681901,
-0.0178908,
0.0036805514,
0.0065724133,
0.015414039,
-0.00633719,
0.0016941259,
0.001499548,
-0.031160157,
0.00683531,
-0.025445616,
-0.011311469,
-0.018499613,
0.0060362425,
0.0144869825,
-0.010557371,
-0.0031149779,
0.0049811974,
-0.014265596,
0.0043793027,
0.010093843,
0.036335066,
0.006734994,
-0.0013447503,
0.023909748,
-0.002948938,
-0.006091589,
0.021778902,
-0.033484716,
0.035172787,
0.0123423,
-0.024573907,
0.021709718,
-0.015524732,
-0.014819062,
-0.018582633,
-0.009166786,
-0.024380194,
0.046657216,
0.016133545,
-0.020768825,
0.0020633917,
-0.014722206,
0.014749879,
-0.010702656,
0.0051714513,
-0.009574968,
-0.022180164,
0.011899527,
-0.023328608,
0.024297174,
-0.0070843697,
-0.021363802,
-0.011124674,
0.028226785,
-0.012930358,
0.0074164495,
-0.006925248,
-0.0076862643,
-0.024366356,
-0.010751084,
0.0015306805,
-0.0025009762,
0.024241827,
0.015939832,
0.012169342,
0.013158663,
0.026303489,
-0.0038292955,
-0.021432985,
0.010778758,
0.011519019,
-0.0041025695,
-0.002978341,
0.0068180137,
-0.018001493,
0.022913508,
0.028586539,
-0.005925549,
-0.011899527,
-0.024449376,
-0.006548199,
0.03309729,
-0.013068724,
-0.016216565,
0.009381255,
-0.05138935,
-0.04070745,
-0.011519019,
-0.0085303,
-0.012190097,
-0.028641885,
-0.011788834,
0.0069217887,
0.00070566963,
0.04051374,
-0.016534807,
0.030495998,
0.0052302573,
0.026815446,
0.0039918763,
0.034702342,
-0.0027102556,
-0.01793231,
-0.010778758,
0.017987657,
0.015649261,
-0.011325305,
0.0009979691,
0.009173705,
0.0045695566,
0.012459911,
-0.0008531165,
-0.018416593,
-0.00633719,
-0.008883135,
-0.0032619925,
-0.020561276,
-0.014528492,
0.017461864,
-0.054903865,
0.0069114114,
-0.011498264,
-0.008108282,
0.008468036,
-0.034010507,
-0.03118783,
0.028475845,
-0.012197015,
0.039434478,
0.0034574352,
0.00960956,
0.023494648,
0.0002363042,
-0.023549994,
-0.020879518,
0.024172643,
0.008730932,
0.013013378,
0.010861778,
-0.010294475,
-0.016714685,
-0.012058648,
0.00658625,
-0.028309805,
-0.026718589,
-0.0016379146,
-0.0056730304,
-0.003756653,
-0.018278226,
-0.0007679346,
-0.043004338,
0.039434478,
-0.014196413,
0.0050503807,
-0.0077900393,
-0.0020409073,
-0.019827932,
0.02651104,
0.008004507,
0.02609594,
-0.019288303,
-0.010813349,
-0.0026739344,
-0.028946292,
-0.0076101627,
0.010716492,
-0.004510751,
0.029389065,
0.00944352,
-0.020893356,
-0.004161375,
-0.00030678467,
-0.010322148,
-0.003964203,
-0.013400804,
0.033291,
-0.013290111,
-0.0062610884,
0.0059497636,
-0.0041440795,
0.00035953693,
0.0042686095,
0.003649419,
-0.023093384,
-0.012328464,
0.020243032,
0.011954874,
0.014293269,
-0.014542329,
-0.018817857,
-0.018983897,
0.006319894,
-0.024781456,
-0.0062403334,
0.013539171,
-0.03359541,
0.0103429025,
-0.0044000577,
0.020713478,
0.019288303,
0.005185288,
0.00048860704,
-0.013781313,
0.010349821,
-0.009270562,
0.0071466346,
0.021391476,
-0.012349218,
-0.004220181,
-0.000708264,
0.021543678,
-0.03511744,
0.005863284,
-0.03185199,
-0.01304797,
0.007596326,
-0.0051887473,
-0.0074164495,
0.027548788,
-0.009637233,
0.009637233,
0.0024404407,
0.013435396,
0.00018982167,
0.010197618,
0.009872456,
-0.024380194,
-0.00070264284,
0.01606436,
-0.016188892,
0.0010585045,
0.0018575715,
-0.027368912,
0.015220325,
-0.019827932,
-0.0054654805,
-0.020367563,
0.0076655094,
-0.019689566,
-0.018942386,
0.028129928,
0.0021481414,
-0.02601292,
0.016687011,
-0.0051091863,
-0.013179418,
-0.022775142,
0.0019146478,
0.008869299,
-0.017129784,
-0.025238067,
-0.0058909575,
-0.0005556283,
-0.024241827,
-0.020519765,
-0.008585647,
-0.025210394,
0.021599025,
0.013691374,
-0.03309729,
-0.026704753,
-0.007070533,
-0.026206633,
0.0023159108,
-0.011560529,
-0.0031201667,
-0.0018593011,
0.008592566,
0.008668667,
-0.018416593,
-0.0151373055,
0.0025044354,
0.017185131,
0.021266945,
0.04427731,
0.013034133,
0.017129784,
0.02323175,
-0.053824604,
0.018402757,
0.014736042,
-0.0031651359,
-0.01242532,
0.025445616,
-0.004801321,
0.022166329,
-0.026026756,
-0.0070636147,
0.011920282,
-0.00646172,
0.010889451,
-0.04120557,
-0.0067557488,
0.01909459,
0.0041959668,
-0.0068491464,
0.008274322,
-0.008135956,
0.022443062,
0.003673633,
0.011525937,
-0.029278371,
0.015275672,
-0.027894706,
0.021211598,
0.009436602,
-0.007928406,
-0.011456754,
0.016700847,
-0.008149792,
-0.030579017,
0.0028693771,
-0.019883279,
-0.02489215,
0.03359541,
0.013802067,
0.007783121,
-0.0010083466,
0.007340348,
0.014597676,
0.0004912014,
0.0008245784,
0.0029800704,
0.0066243005,
0.014390126,
0.02009083,
0.0015687313,
-0.015026612,
-0.019827932,
-0.019744912,
0.009747926,
-0.005143778,
-0.01213475,
-0.03143689,
-0.00020744179,
-0.013082561,
-0.0056349793,
0.0030717384,
0.013608354,
-0.01714362,
-0.024283336,
0.019274466,
0.18186904,
0.0023574207,
0.03359541,
-0.00011253096,
0.0010645579,
-0.017129784,
0.0068906564,
0.00010366685,
-0.0030492537,
0.0064167506,
0.01805684,
-0.0048359125,
-0.020284543,
-0.0013931786,
0.004905096,
-0.015676934,
-0.02476762,
-0.04546726,
-0.027922379,
0.007381858,
0.0069944314,
0.0062887617,
0.0054481844,
-0.00036753627,
0.019634219,
0.008170547,
-0.03085575,
0.00633719,
0.01209324,
0.0022121358,
-0.028365152,
0.019398997,
0.0030423354,
0.036971554,
0.031547584,
0.013815904,
-0.0009434872,
-0.008807033,
-0.00039910115,
-0.0016102412,
0.0019613465,
0.008253567,
-0.0036874698,
-0.00040904625,
-0.027867032,
0.0012461641,
-0.013456151,
-0.018250553,
-0.0003223509,
-0.012231607,
-0.013767476,
0.016451787,
0.010024659,
0.0010144,
0.011691977,
-0.004891259,
0.008385016,
0.033540063,
-0.0042928234,
0.02083801,
-0.023605341,
0.0048774225,
-0.021363802,
0.008876217,
-0.009298235,
0.020229196,
0.003953825,
-0.02692614,
0.032571495,
-0.014196413,
0.012660543,
-0.027673319,
0.009007665,
0.020948702,
-0.032045703,
-0.0014476605,
0.027465768,
0.05089123,
0.03342937,
0.01714362,
-0.012079404,
0.0051783696,
-0.033180308,
-0.024864476,
0.0006196229,
-0.019578872,
0.027189035,
-0.012868093,
0.0026047511,
0.025002843,
0.0069563803,
0.002729281,
-0.0045626382,
0.005814856,
0.0063060573,
0.0019492394,
-0.0076309177,
-0.0034678127,
0.0034038182,
0.022622937,
-0.03110481,
0.07693183,
-0.00028884027,
0.0014718747,
-0.0024006604,
0.0046733315,
-0.018693326,
0.016825378,
-0.019246792,
-0.0049639014,
-0.0011960062,
-0.03143689,
0.014749879,
-0.01284042,
0.006423669,
0.014459309,
0.014265596,
-0.02576386,
0.02042291,
0.005036544,
0.022512244,
0.0024663846,
-0.02642802,
0.021405311,
-0.012127832,
0.00323086,
-0.035643235,
-0.02306571,
-0.020478256,
-0.026898466,
0.0059013353,
0.010764921,
0.021834249,
0.009132195,
-0.033180308,
-0.009097603,
0.0068699014,
0.0026393428,
-0.020132339,
0.0062195784,
-0.0035906131,
0.008724013,
-0.008876217,
-0.0008167953,
0.0124945035,
-0.0022000289,
0.0068906564,
0.024407867,
0.0021550597,
-0.010038496,
-0.012833501,
-0.011588202,
0.015123469,
-0.0040126313,
-0.0044969143,
-0.026718589,
-0.036888532,
-0.03359541,
-0.014210249,
0.028309805,
-0.016700847,
-0.007153553,
0.03378912,
-0.008564892,
-0.0003340256,
0.011678141,
-0.17733063,
0.017461864,
0.026815446,
-0.037580367,
0.006690025,
0.029887185,
0.031547584,
0.019551199,
-0.010508942,
0.008398852,
0.019634219,
0.00084100943,
-0.023287097,
-0.034979075,
0.0012124373,
-0.006278384,
-0.014210249,
0.040984184,
0.01697758,
-0.0033847927,
0.0057837237,
-0.015663099,
0.004282446,
-0.002087606,
0.010910206,
0.017198967,
-0.018734837,
-0.019883279,
-0.025694676,
-0.01801533,
-0.013400804,
0.0076032444,
0.018817857,
-0.009187542,
0.021778902,
0.01598134,
0.0051091863,
0.0034851085,
-0.0070428597,
0.021391476,
0.013802067,
0.012286954,
-0.0032827475,
-0.023121057,
-0.013317784,
0.023024201,
0.030468324,
0.0039918763,
0.0010541804,
0.0047321375,
-0.0030215804,
-0.021405311,
0.011352979,
0.0027431177,
0.03508977,
0.0052925223,
-0.0075202244,
0.007423368,
-0.003370956,
-0.015109632,
-0.007430286,
-0.018914713,
0.03035763,
0.014237923,
-0.013532253,
-0.031049464,
-0.00084706297,
-0.009574968,
-0.03110481,
-0.002571889,
0.0076516727,
-0.004697546,
-0.019232957,
-0.019786423,
0.03295892,
0.014653022,
-0.008620239,
0.00927748,
-0.0012357866,
0.00046439288,
-0.0083919335,
0.0076032444,
0.004808239,
-0.01589832,
0.0032343192,
-0.00024041196,
0.018707164,
-0.008108282,
-0.03392749,
0.0028140305,
0.020796498,
-0.0064582606,
0.004451945,
-0.012003302,
0.03835522,
0.012390728,
-0.0036425006,
0.021529842,
-0.002696419,
-0.013352376,
0.008841625,
0.00085052213,
-0.016908398,
0.010156108,
0.013075643,
-0.018209044,
-0.017669413,
-0.022097144,
0.023536157,
-0.0062092007,
-0.020160012,
0.014805226,
0.0062092007,
0.04294899,
-0.003441869,
0.016368767,
-0.0040818145,
-0.01598134,
-0.0129026845,
-0.022415388,
0.054820843,
0.009208296,
0.014805226,
0.004728678,
-0.0027586839,
-0.02543178,
-0.13382816,
-0.022678284,
-0.013732884,
0.02476762,
-0.0014052857,
0.006700402,
0.0037428164,
0.008869299,
-0.01809835,
0.021958778,
0.002750036,
-0.028226785,
0.004386221,
-0.004344711,
-0.0090422565,
0.016700847,
0.0039987946,
-0.022609102,
-0.036833186,
0.004718301,
0.00080036424,
-0.008336587,
0.008952319,
-0.004617985,
0.018734837,
-0.023660688,
-0.027106015,
0.010128435,
0.03425957,
0.021765064,
-0.008890053,
-0.028337479,
0.007596326,
-0.003964203,
-0.023743708,
0.003242967,
-0.012653625,
-0.0100177415,
0.048566673,
-0.008979992,
-0.0031357328,
-0.003400359,
-0.008682503,
-0.0015912158,
0.015787628,
0.0034314916,
-0.0012945924,
0.010502025,
-0.022595264,
-0.012197015,
-0.031713624,
-0.018070677,
-0.022207838,
-0.003988417,
0.02067197,
-0.018278226,
0.010806431,
0.037165266,
-0.051749106,
-0.039268438,
0.008350424,
0.014154903,
-0.0038846422,
0.007319593,
0.009097603,
0.010197618,
-0.0103429025,
-0.03558789,
0.020893356,
-0.022609102,
-0.015261835,
0.009962395,
-0.0056972443,
0.0066139232,
-0.008454199,
-0.00040450608,
-0.007409531,
-0.027908541,
0.029361391,
-0.0040333862,
0.0043343334,
-0.018333573,
0.019232957,
-0.021695882,
0.019869443,
0.011359897,
0.032405455,
0.011415244,
0.004240936,
-0.015912158,
-0.0026618273,
0.039296113,
-0.009907048,
-0.021045558,
-0.012266198,
0.021502169,
-0.008564892,
-0.027770175,
0.0024698437,
-0.0026895006,
-0.030966444,
0.0016309962,
-0.06425744,
0.0070394003,
0.012667461,
-0.020381398,
-0.0010489917,
-0.027230546,
-0.004583393,
-0.0017053683,
0.009242889,
-0.010169945,
-0.045577955,
-0.012625951,
-0.01880402,
-0.0061607724,
-0.015524732,
0.009491948,
0.038936358,
0.0014078801,
0.026981486,
-0.0080252625,
-0.025072027,
0.009858619,
0.001201195,
0.016354932,
0.006143477,
0.000993645,
-0.027977725,
0.019827932,
-0.01880402,
-0.018112186,
0.0016500216,
-0.015427875,
-0.010937879,
0.0026306948,
0.0026981486,
0.0007355049,
-0.015953667,
0.0250997,
0.028309805,
0.0021498709,
-0.030136244,
-0.04419429,
-0.0078107943,
0.020353725,
0.0008258756,
0.017489538,
-0.028973965,
0.011920282,
0.0026722047,
-0.01697758,
0.027604135,
0.018236717,
0.00014150146,
-0.041316263,
-0.028420499,
0.001196871,
-0.026414182,
-0.01855496,
-0.013442314,
-0.0029921776,
0.039130073,
0.0059497636,
0.00426515,
-0.00081160653,
-0.0022692122,
0.010986308,
-0.019288303,
0.00044623227,
-0.002497517,
-0.05418436,
-0.034536302,
0.0027396586,
0.0097340895,
0.014805226,
-0.0012712431,
-0.022207838,
-0.0046733315,
0.021917269,
0.0023868238,
-0.0037808672,
0.010453596,
0.01901157,
-0.029721145,
0.011941037,
0.007803876,
-0.011013981,
0.026248142,
0.016534807,
-0.008260486,
0.026220469,
0.008225894,
0.026192795,
0.00931899,
0.009782518,
-0.012819665,
0.016424114,
-0.00068275264,
0.002750036,
0.018444266,
0.023342444,
-0.016908398,
0.0031011412,
0.0077900393,
-0.022180164,
-0.012515258,
0.011899527,
-0.03810616,
-0.032654516,
0.0016552104,
-0.005915172,
0.015275672,
-0.0063302717,
0.0068110954,
0.024781456,
-0.004953524,
-0.0010282367,
-0.021128578,
-0.014763716,
0.009208296,
0.013137908,
0.021529842,
0.029610451,
-0.0034730015,
0.0058079376,
0.003735898,
0.008834707,
0.023453137,
-0.004175212,
0.027285893,
-0.011823425,
0.00869634,
-0.0045626382,
-0.019440506,
-0.011325305,
-0.015151142,
0.022844324,
0.0006684836,
-0.015275672,
0.009754845,
0.079588465,
0.020395236,
-0.013912761,
-0.008440362,
-0.029472085,
0.023134895,
-0.0036874698,
-0.0058286926,
0.021778902,
-0.029665798,
0.01859647,
-0.010453596,
0.03143689,
-0.025542473,
-0.008744769,
0.0076724277,
-0.010633472,
0.03805081,
-0.020326052,
-0.01342156,
0.028365152,
-0.0065170666,
0.016050525,
-0.0062437924,
-0.027438095,
0.0011527666,
0.027700992,
-0.033152636,
0.003305232,
-0.023439301,
0.004112947,
0.013193254,
-0.021958778,
-0.019302139,
0.007617081,
-0.029721145,
0.00011009873,
0.0077070193,
0.02397893,
0.018859366,
0.020685805,
-0.010730329,
-0.0057975603,
-0.023757543,
-0.004749433,
0.013636027,
-0.013200173,
-0.0040437635,
-0.013428478
] |
The hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) enzymes represent novel targets for the treatment of anemia, ulcerative colitis, and ischemic and metabolic disease inter alia. We have identified a novel small-molecule inhibitor of PHD, 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), through structure-based drug design methods. The pharmacology of JNJ- | [
-0.01890893,
-0.018084489,
0.006874765,
-0.034945615,
-0.022166796,
0.02590337,
-0.028828802,
-0.0017768674,
-0.008889324,
0.00014658326,
0.023110913,
0.01652869,
0.021754576,
0.008091479,
-0.020212075,
0.0063063004,
0.025504448,
-0.018416924,
-0.015730845,
0.008796242,
-0.04042415,
0.027897982,
0.0025198606,
-0.020092398,
-0.011954378,
0.02477309,
0.014680349,
-0.026395375,
-0.001013097,
-0.02312421,
0.009786899,
-0.018948821,
0.0026096182,
-0.0066054924,
-0.006293003,
-0.0038928192,
-0.006711872,
-0.0065788976,
0.012911793,
0.0015682642,
0.038376346,
0.0028057552,
-0.0126192495,
0.0068814135,
-0.010012955,
-0.012612601,
0.013244228,
-0.009009001,
-0.0071872543,
0.02389546,
0.0051062084,
0.02158171,
0.02090354,
-0.00091669074,
0.007885369,
-0.009454465,
0.018656278,
0.022552421,
-0.01225357,
-0.0067949807,
-0.0027774982,
-0.016156362,
-0.031541474,
0.031940397,
-0.00034116188,
-0.00059796823,
0.00050779514,
0.02023867,
0.0014452632,
0.010305499,
0.04196665,
0.015770737,
-0.009368031,
-0.009348085,
0.024746494,
-0.027179923,
-0.02914794,
-0.00373325,
0.010757611,
-0.010485014,
0.039573114,
-0.024015136,
-0.024294382,
0.016608475,
0.03372225,
-0.0011660174,
-0.013084659,
0.01704729,
0.0149064055,
0.005767755,
0.028243715,
0.02450714,
0.020970028,
0.028509663,
-0.014587267,
0.026461862,
0.005515104,
0.019587096,
0.025012443,
-0.025158715,
-0.011648538,
0.00491672,
-0.0122269755,
-0.008769647,
-0.033642467,
-0.0023220617,
-0.016541988,
-0.010292201,
0.023044426,
0.012207029,
-0.007832179,
0.037738074,
0.005262453,
-0.048110057,
0.017619079,
-0.027179923,
0.03635514,
0.020251967,
0.00039580595,
-0.028190525,
0.017087182,
0.032951,
-0.018510006,
-0.021608304,
0.012479627,
0.0017519348,
-0.0154516,
-0.012439734,
0.01405537,
0.0003500961,
0.014999487,
0.0200791,
0.0073468233,
-0.022140201,
-0.04470592,
0.02142214,
-0.007679259,
-0.023350265,
-0.024214597,
-0.028935181,
0.008669917,
0.026488457,
-0.007885369,
-0.004783746,
-0.030238329,
0.0003276567,
0.012812062,
0.0049566124,
0.008490401,
-0.011907837,
-0.00094660994,
-0.016595177,
0.0127123315,
0.009660574,
0.0039027922,
0.026515052,
0.012958334,
0.029839406,
-0.0096871685,
0.0017885027,
0.0032229617,
-0.03776467,
-0.00015302419,
-0.006003784,
0.017326536,
0.0105647985,
0.003404139,
0.0015557979,
-0.005661376,
0.0024999145,
-0.0060636224,
0.031036174,
-0.031594664,
0.0074399053,
0.004268471,
0.012074055,
0.01565106,
0.016156362,
-0.010418527,
-0.0068814135,
-0.013111254,
0.020571105,
0.008118073,
-0.018669575,
0.013117903,
0.010584745,
0.0030251625,
-0.027924577,
0.00622984,
-0.04486549,
0.0056680245,
0.022858262,
-0.00093996123,
-0.009866684,
-0.6369995,
-0.03723277,
0.0039460086,
-0.023363562,
0.0045510414,
0.02631559,
0.017539294,
-0.007872071,
-0.0054054004,
0.0135434205,
0.019228065,
0.022751883,
-0.0009806845,
-0.012107299,
-0.0040357662,
-0.023190696,
-0.0012333355,
-0.038190182,
0.013762827,
-0.01575744,
0.0020561132,
0.013829314,
-0.009647276,
-0.008636673,
0.030318113,
0.01369634,
0.04850898,
-0.0088095395,
0.004983207,
0.012353301,
0.00478707,
0.02466671,
-0.021235976,
-0.008503699,
0.05170036,
-0.013816017,
0.008270994,
0.020371644,
0.040876262,
0.018470114,
-0.014600565,
-0.0024916036,
0.023988541,
-0.008111425,
-0.00932149,
0.022166796,
0.018057894,
0.0077258,
0.020930136,
0.003666763,
0.0031847316,
0.005132803,
-0.008743052,
0.0123200575,
0.019560501,
0.012167137,
0.027366087,
-0.021621602,
0.023230588,
0.009122029,
-0.015531384,
0.007333526,
-0.020890243,
-0.017260049,
-0.007885369,
0.026661323,
-0.0013854248,
0.006961198,
0.0011385914,
0.015544682,
0.006273057,
0.024374167,
-0.010624637,
0.006894711,
0.0355307,
0.019786557,
0.016196255,
0.030424492,
-0.0034274093,
0.02183436,
0.009993009,
0.003517167,
-0.020305157,
0.0144675905,
0.03646152,
0.010777557,
-0.013643151,
0.019267958,
-0.004192011,
-0.00911538,
0.0247199,
-0.013510177,
-0.0077258,
-0.029759621,
-0.031913802,
0.015052677,
-0.00092250836,
0.002569726,
0.025624124,
-0.019986019,
-0.003686709,
-0.018416924,
-0.0060902173,
-0.0039061166,
0.009062191,
0.01575744,
-0.025172012,
-0.0074332566,
0.023922054,
-0.032711647,
-0.0028755667,
-0.014919703,
-0.023177398,
0.004876828,
0.008576835,
-0.0126657905,
0.013423744,
-0.003309395,
-0.017805243,
-0.03739234,
0.030424492,
-0.00122918,
-0.013330662,
-0.006934603,
0.0026279022,
0.019108389,
-0.00008118697,
-0.018257355,
-0.00767261,
-0.025278391,
0.014534078,
0.011422482,
0.025304986,
-0.002868918,
0.0032329347,
0.0048568817,
0.03013195,
0.00731358,
0.025531042,
-0.01153551,
-0.019174876,
-0.006189948,
-0.00075379736,
0.003676736,
-0.009294895,
-0.013071362,
-0.012492924,
0.0038196833,
0.007885369,
0.00932149,
-0.0050031533,
-0.012572709,
-0.029546862,
0.021196084,
0.01024566,
-0.02694057,
-0.00029171212,
-0.016435608,
-0.023190696,
-0.005289048,
0.0029952433,
0.027179923,
-0.0063628145,
0.00787872,
-0.011794809,
-0.021807766,
0.016781341,
0.014600565,
-0.011821404,
-0.020065803,
0.0038595756,
-0.009560843,
-0.015544682,
0.0064093554,
-0.0043914723,
0.012612601,
-0.0021907496,
0.005661376,
-0.022313068,
0.0019148282,
0.0055018067,
-0.02281837,
-0.021900848,
-0.01153551,
0.007493095,
0.010258958,
0.0023752511,
0.043402772,
0.0009482721,
0.029440483,
-0.020810459,
0.0060470006,
-0.0087629985,
0.025118822,
0.00041762204,
-0.011934432,
0.0048469086,
0.0027642008,
-0.012526168,
0.043083634,
0.034387123,
-0.02606294,
0.016209552,
-0.008211155,
0.019600393,
-0.013091308,
0.0042252545,
-0.016302634,
-0.0039094407,
0.012579357,
-0.008656619,
-0.007147362,
-0.01864298,
0.0028921885,
-0.00504637,
0.015292031,
-0.029360699,
0.00571789,
-0.024267787,
-0.039413545,
-0.0019148282,
0.007147362,
0.013935694,
-0.0039825765,
-0.00097569806,
-0.020571105,
0.00901565,
0.010072794,
0.01616966,
-0.017220156,
-0.002701038,
0.009022298,
-0.01374953,
0.007852125,
-0.019108389,
0.009986361,
0.014321319,
-0.022858262,
0.043455962,
0.017419618,
-0.0050230995,
0.00079950725,
0.0058575124,
0.005475212,
0.0046009067,
0.009693817,
0.045078248,
-0.005525077,
-0.013882504,
0.024906063,
-0.016714854,
0.010624637,
0.022366257,
-0.009088785,
0.01611647,
-0.0062797056,
0.008217804,
0.03683385,
0.039785873,
0.012911793,
0.0055483477,
-0.0069479006,
-0.0025664016,
-0.011508916,
0.0075928257,
0.011980973,
-0.0042418763,
-0.011488969,
0.00049283553,
0.0035204913,
-0.02425449,
0.012851954,
0.0054419683,
-0.018510006,
0.01601009,
-0.018616386,
0.002411819,
0.010737665,
0.021209382,
-0.0034772747,
-0.006422653,
-0.01745951,
0.020424834,
0.030397898,
-0.012399842,
0.0025630773,
-0.025770396,
-0.005308994,
-0.0019480718,
0.022778478,
-0.009228408,
0.0037099796,
0.0024749818,
0.005262453,
-0.02158171,
-0.027366087,
0.0050397213,
-0.013456987,
0.0018483411,
-0.00015707574,
-0.021914145,
-0.013144498,
-0.020052506,
0.0014020465,
0.044519756,
0.012552762,
0.002430103,
-0.0083707245,
0.009088785,
-0.013909099,
0.011475672,
0.010272255,
0.007858774,
-0.008377373,
-0.021807766,
0.010844044,
-0.014201642,
0.00607692,
0.014534078,
-0.018470114,
-0.0055383747,
-0.017220156,
0.0012840319,
0.019068496,
0.017326536,
0.015119164,
-0.0048003676,
0.022485934,
-0.0005140283,
0.01627604,
-0.0055849156,
-0.023350265,
0.024786387,
-0.0134037975,
0.013257526,
-0.0062863543,
0.0079784505,
-0.006416004,
-0.0070875236,
0.010072794,
-0.005212588,
-0.033695657,
-0.006339544,
0.009840089,
-0.00024039239,
-0.009241706,
0.016342526,
0.008802891,
0.03217975,
0.009175219,
0.04470592,
0.034121174,
0.01925466,
-0.009195165,
0.009620681,
-0.022898154,
-0.000332851,
0.0038928192,
-0.021914145,
-0.027791603,
-0.010445122,
-0.015571277,
0.028030956,
0.007074226,
0.021036515,
0.01715367,
0.00048410913,
-0.0026694566,
-0.0018400302,
0.0015416694,
0.007659313,
0.008164614,
-0.00922176,
-0.011734971,
0.025757099,
-0.022033822,
-0.017486105,
-0.010371986,
0.012592655,
-0.008005045,
0.0048735035,
0.008244399,
-0.013204336,
-0.012180435,
-0.0029686484,
-0.035982814,
0.021967335,
-0.0046374747,
0.021435438,
0.018018002,
-0.004574312,
-0.02909475,
-0.015956901,
-0.018377032,
0.024640115,
-0.016448906,
-0.015119164,
0.027897982,
0.00932149,
-0.0056414297,
0.006376112,
-0.010405229,
0.022419447,
-0.008157966,
-0.022140201,
-0.015012785,
0.0149064055,
-0.020863649,
-0.0016522042,
-0.008656619,
-0.011601997,
-0.02507893,
-0.016355824,
0.009740358,
0.012705683,
-0.010066145,
0.009434518,
-0.0040856316,
-0.020172182,
0.016262742,
0.020863649,
0.028855396,
-0.014853216,
-0.008736404,
-0.0040557124,
-0.014135155,
0.014933,
-0.028403284,
0.0015931969,
-0.02513212,
0.005082938,
-0.004025793,
-0.010624637,
0.00258801,
0.031062769,
0.010119335,
0.0101725245,
0.0068016294,
0.026169319,
0.020451428,
-0.02425449,
0.01534522,
-0.00067359733,
-0.018775955,
0.010724368,
-0.007792287,
0.040397555,
0.01874936,
-0.027552249,
0.009268301,
0.0048635304,
-0.03518497,
-0.007240444,
0.013510177,
-0.014015478,
0.042259194,
-0.000759615,
-0.015305328,
-0.036036003,
-0.019347742,
-0.0126192495,
-0.005644754,
-0.01410856,
-0.032259535,
-0.012579357,
-0.0360626,
0.01756589,
-0.0066919257,
0.0014219927,
-0.027632033,
-0.015278733,
0.0061600287,
-0.011681781,
-0.0013205998,
-0.021900848,
0.0034772747,
-0.006921306,
-0.0060071084,
-0.024520438,
-0.039307166,
-0.00052275474,
-0.021555115,
0.01740632,
0.03888165,
0.032472294,
-0.011768214,
0.00079576735,
0.02199393,
0.010132632,
0.0017120425,
-0.00031664476,
0.002484955,
-0.0437751,
0.019547204,
0.025690611,
-0.026116129,
0.00957414,
-0.015105867,
0.010425176,
0.019081794,
-0.01925466,
-0.017805243,
0.011322752,
-0.02821712,
-0.016834531,
0.0048103407,
-0.024733197,
-0.008390671,
-0.037924234,
-0.017180264,
0.026993759,
-0.0079319095,
0.016914316,
0.0045443927,
0.011449077,
-0.014387806,
0.017313238,
0.024985848,
0.01550479,
-0.0007105808,
-0.00196968,
0.02337686,
0.01143578,
0.036036003,
0.016967505,
0.024055028,
-0.008251048,
-0.037418935,
-0.0006096035,
0.010637934,
-0.0065290323,
0.009068839,
-0.0039892253,
-0.025411366,
-0.004527771,
-0.0063328953,
0.00036588675,
-0.05443963,
0.007426608,
0.016901018,
-0.017845135,
0.011169831,
-0.012127245,
-0.008902621,
0.012586006,
-0.009461113,
0.011954378,
-0.017260049,
0.030451087,
0.02688738,
0.0009665561,
-0.027366087,
-0.0044479864,
-0.012519519,
0.004491203,
0.02327048,
0.01844352,
-0.0019547204,
-0.03574346,
-0.0033077328,
0.011116642,
-0.0042086327,
-0.026209211,
0.011070101,
0.003234597,
0.01885574,
-0.006133434,
-0.007606123,
-0.005707917,
0.0057777283,
-0.00029378984,
0.017685566,
-0.021621602,
-0.0180313,
0.0014785066,
0.004192011,
-0.01498619,
-0.005019775,
0.0035903028,
-0.015411708,
-0.0010962059,
-0.032605268,
-0.0038130346,
0.017273346,
-0.01138259,
0.02178117,
-0.009793548,
0.03069044,
0.0052292095,
0.0015316963,
-0.004324985,
-0.015371815,
-0.019015307,
0.029759621,
-0.011016911,
-0.0031182445,
0.02749906,
0.008064884,
0.007892017,
-0.02642197,
-0.009122029,
-0.023563024,
-0.02389546,
-0.007326877,
0.023775782,
0.00069603673,
-0.011548808,
0.011821404,
-0.02744587,
-0.0075063924,
-0.016954208,
-0.013144498,
0.035982814,
-0.031860612,
-0.014321319,
-0.0074532027,
0.005927324,
0.0021608304,
0.010604691,
0.004660745,
0.011781512,
0.015837224,
-0.020158885,
0.013576664,
0.020916838,
-0.00021462863,
-0.011867945,
0.009082137,
-0.011389239,
-0.023908757,
0.025451258,
-0.016914316,
-0.037525315,
0.010651232,
-0.0049000983,
0.015012785,
0.015292031,
-0.026116129,
0.00922176,
0.01292509,
0.01570425,
-0.009301544,
-0.013603259,
0.023523131,
-0.037684884,
0.030929795,
0.020837054,
-0.01374953,
-0.0038795217,
-0.0069944416,
0.0035936271,
-0.0061134878,
-0.0025564285,
-0.011103344,
-0.01277217,
0.0010704421,
-0.00075836835,
0.0017402995,
-0.0014560672,
-0.010704421,
-0.019640286,
0.025092227,
0.01045177,
-0.0047804215,
-0.023868864,
0.008669917,
-0.0018516654,
-0.0005651403,
-0.028881991,
-0.014002181,
0.0036069246,
-0.03212656,
-0.03856251,
0.0031847316,
0.0061301095,
0.04350915,
0.0029935811,
-0.04356234,
-0.015797332,
-0.023775782,
-0.040663503,
0.007772341,
-0.012991577,
-0.0052823992,
-0.00027197375,
0.0048269625,
-0.014347914,
0.0049765585,
-0.011269562,
-0.0036734117,
0.015119164,
-0.014600565,
0.02070408,
-0.001547487,
0.022751883,
-0.017260049,
-0.028509663,
-0.0075329873,
0.019121686,
-0.0015125812,
-0.01369634,
0.030211734,
-0.022844965,
0.0072337952,
-0.0051427763,
-0.005036397,
0.014946298,
-0.0060835686,
-0.0015408383,
-0.006788332,
-0.005608186,
0.0051461007,
0.014706944,
0.0019580447,
-0.007892017,
0.00512283,
-0.013490231,
-0.029493673,
-0.025637422,
-0.009334788,
0.0013845937,
-0.026156021,
-0.0015832238,
-0.0014568983,
0.0032595296,
0.020158885,
0.0044513107,
0.001294005,
-0.01503938,
0.014015478,
0.0058109714,
-0.012659142,
0.03316376,
0.018190868,
-0.0019730043,
-0.008217804,
-0.0021973983,
-0.022206688,
-0.009999658,
-0.010332094,
-0.01168843,
-0.020890243,
0.023110913,
-0.005139452,
-0.01410856,
-0.036275357,
0.011469023,
-0.010019604,
-0.0077390973,
-0.007652664,
0.007898666,
-0.0066786283,
-0.012592655,
-0.00012746821,
-0.017805243,
0.00066902634,
0.009773602,
-0.021129597,
-0.011781512,
0.026102832,
0.20126972,
0.017698864,
0.023975244,
0.011914486,
0.0011975986,
0.006622114,
0.013097957,
-0.0034839234,
-0.015983496,
-0.0020245318,
0.021674791,
-0.0009997996,
-0.01756589,
-0.00834413,
0.0058209444,
-0.014547375,
-0.011143236,
-0.016821234,
-0.039892253,
-0.02142214,
-0.008144668,
0.0031631233,
0.006961198,
0.0019248013,
0.010857342,
-0.0017785296,
-0.00044878785,
0.030185139,
0.032685053,
0.0008207,
-0.019174876,
0.012832008,
0.004973234,
-0.0075329873,
0.012133894,
-0.011528862,
-0.010066145,
-0.01452078,
0.0005372988,
0.0045975824,
0.00615338,
0.009806845,
-0.034121174,
-0.0051461007,
-0.00095990737,
0.0056514028,
-0.012293463,
-0.0110036135,
-0.0025215228,
0.005345562,
-0.04305704,
-0.003319368,
0.038988028,
0.03085001,
0.017845135,
-0.01498619,
0.011136588,
0.026448565,
-0.012612601,
-0.014201642,
0.019494014,
-0.004803692,
-0.0039094407,
0.009062191,
-0.012539465,
0.029334104,
-0.027472464,
-0.024188003,
0.00009666599,
-0.002597983,
0.0033642468,
-0.013071362,
-0.011482321,
0.009181867,
-0.0040656854,
-0.026408672,
0.026156021,
0.034493502,
0.0041521187,
0.035051994,
-0.012113947,
-0.018829145,
-0.028589448,
0.009633979,
-0.018882334,
-0.041062426,
0.016794639,
0.015823927,
-0.03600941,
-0.00012559826,
0.018456817,
0.0041986597,
-0.016914316,
0.005874134,
0.009028947,
-0.015185651,
-0.006209894,
0.023563024,
-0.002607956,
-0.0040357662,
-0.01710048,
0.08302908,
-0.01987964,
0.007326877,
-0.01374953,
0.01663507,
-0.01369634,
-0.00029815303,
0.0075063924,
0.013576664,
0.014002181,
-0.018563196,
-0.0018500033,
-0.010465068,
0.0069479006,
0.027924577,
-0.018510006,
-0.032764837,
0.023802377,
-0.02925432,
0.011668484,
-0.009946468,
0.012399842,
0.031860612,
-0.005721214,
-0.0024882792,
-0.010584745,
0.00035570594,
0.0020195453,
-0.025810288,
-0.0042551737,
0.0008593456,
0.012579357,
-0.015278733,
0.003919414,
0.029998975,
0.0037831154,
0.00767261,
0.0007562906,
0.0175127,
-0.024812981,
-0.008124722,
0.011708376,
0.022525826,
0.0045144735,
-0.028642638,
0.017180264,
-0.033349924,
-0.0005738667,
-0.020571105,
-0.0055084554,
-0.021874253,
-0.0025580907,
0.006628763,
0.029014966,
-0.014015478,
-0.009607384,
-0.031993587,
0.0043947967,
0.027113436,
-0.016488798,
0.024693305,
0.03100958,
-0.00726039,
-0.013736232,
-0.0015956901,
-0.16829212,
0.015890414,
0.028483069,
-0.024081623,
0.05076954,
0.0035470861,
0.015198949,
-0.01410856,
-0.0060004597,
0.008357427,
0.023882162,
-0.014268129,
-0.031940397,
-0.032365914,
0.013709637,
0.01781854,
-0.011196426,
0.017698864,
0.011063452,
-0.0029802837,
-0.0052857236,
0.008536942,
0.0038562512,
-0.0042086327,
0.005824269,
0.011901189,
0.007034334,
0.0050397213,
-0.0021807766,
0.0072537414,
-0.021289166,
0.010644583,
0.021435438,
-0.0047372053,
0.016661664,
-0.011502267,
0.0014959595,
0.012393193,
-0.012532816,
0.010139281,
0.006080244,
-0.002278845,
0.010996965,
-0.019161578,
-0.016076578,
0.03228613,
0.00993982,
0.000965725,
0.032685053,
0.0063794362,
0.015278733,
-0.020810459,
0.018257355,
0.012326706,
0.015770737,
0.0018749359,
-0.006236489,
0.012413139,
-0.010624637,
-0.027259707,
-0.004108902,
-0.016049983,
0.019427527,
0.0041886866,
0.0034473555,
-0.012645844,
0.0015250476,
-0.011874594,
-0.028084146,
-0.0026461862,
-0.030344708,
-0.02219339,
0.020052506,
-0.0035470861,
0.015185651,
-0.0021973983,
-0.008251048,
0.00684817,
-0.018869037,
0.0386157,
-0.022126904,
-0.0005281568,
-0.011874594,
-0.027166625,
0.012612601,
0.012373247,
-0.013656449,
-0.0054319953,
-0.030211734,
-0.0051161814,
0.030052165,
-0.03233932,
0.013669746,
0.0018134353,
0.028775612,
0.022060417,
0.009068839,
-0.013078011,
-0.001678799,
0.012851954,
0.022007227,
-0.0036235463,
-0.024015136,
0.015531384,
0.04845579,
0.01977326,
-0.017499402,
0.0037432231,
0.049519584,
0.0043748505,
-0.004767124,
0.0065523027,
0.01333731,
0.026116129,
-0.01581063,
0.0106113395,
0.012113947,
-0.013922396,
-0.01271898,
-0.025464555,
0.06010433,
0.022725288,
-0.031115958,
0.013523474,
-0.015717547,
-0.04191346,
-0.12467659,
0.0012482951,
0.0134968795,
-0.005920675,
0.00070850307,
0.016502095,
0.008211155,
0.00422193,
-0.014254832,
0.018975414,
-0.005102884,
-0.005993811,
0.0058209444,
0.0027874713,
0.024759792,
-0.0036700873,
-0.006106839,
0.0014926351,
-0.025517745,
0.036993418,
-0.019281255,
0.01729994,
-0.020092398,
-0.020065803,
-0.0012699034,
-0.0063894093,
-0.023297075,
0.012599303,
0.006894711,
0.016462203,
0.010664529,
0.00726039,
0.012765521,
0.017885027,
-0.013762827,
-0.01658188,
0.030185139,
-0.01972007,
0.04818984,
-0.033642467,
0.0016738125,
0.010026253,
0.0060470006,
0.007918612,
0.025039038,
-0.0008668254,
-0.0169941,
0.001838368,
0.021342356,
0.008503699,
-0.04664734,
-0.017246751,
-0.023922054,
-0.0026927271,
0.013204336,
-0.030823415,
0.018510006,
0.027312897,
-0.047764324,
0.01256606,
0.012300111,
-0.015690953,
-0.022485934,
0.0047438536,
0.01374953,
-0.008596781,
-0.00813802,
-0.037472125,
0.011621943,
-0.04031777,
-0.021435438,
0.0010563136,
-0.021595007,
0.00968052,
-0.019693475,
-0.01756589,
-0.018044597,
0.0021874253,
-0.005289048,
-0.022964641,
-0.031248933,
-0.021727981,
0.01184135,
-0.040902857,
0.008889324,
0.012187083,
0.012140542,
-0.009507653,
0.017685566,
-0.020970028,
-0.010637934,
0.030530872,
-0.00064492476,
-0.009860035,
-0.022805072,
0.015637763,
0.010930478,
-0.02116949,
0.020438131,
0.025943263,
-0.017246751,
-0.036594495,
-0.06866787,
0.019507311,
-0.008317535,
-0.0037897641,
0.009348085,
-0.020517915,
0.008397319,
0.026156021,
0.022499232,
0.0036002758,
-0.032951,
-0.0023951973,
-0.030264923,
-0.007885369,
-0.019427527,
-0.0009665561,
0.037365746,
0.0113493465,
0.018603088,
-0.004667394,
0.0038462782,
-0.007419959,
-0.011508916,
0.023922054,
-0.022751883,
-0.008895973,
-0.028775612,
0.028429879,
-0.0025780369,
-0.0065057618,
0.01143578,
-0.034280743,
-0.028562853,
-0.0012624236,
-0.021036515,
-0.032046776,
-0.011528862,
0.0029437158,
-0.0051461007,
0.010139281,
-0.010285553,
-0.030557467,
-0.0029320805,
-0.007373418,
0.012173786,
0.009740358,
-0.023403455,
0.019799855,
-0.010677827,
-0.010006307,
0.036089193,
0.0106113395,
-0.0076393667,
-0.014361211,
-0.04010501,
-0.003975928,
0.0011385914,
-0.00365679,
-0.0018948821,
-0.022446042,
0.022552421,
-0.0031032849,
-0.0084638065,
0.0060470006,
0.021302463,
0.0067916564,
-0.009148624,
-0.024812981,
0.025570935,
-0.011156534,
-0.03723277,
0.0030052164,
-0.0046540964,
0.0092483545,
0.015823927,
-0.010844044,
-0.01503938,
0.0065589515,
-0.0011169831,
0.014135155,
0.0283235,
-0.021821063,
-0.018297248,
0.020251967,
0.018097786,
-0.015770737,
-0.00043299716,
0.01539841,
0.01225357,
-0.008616727,
-0.0016538664,
0.008630024,
0.0001357791,
0.015996793,
0.0057245386,
0.023243885,
-0.0013447014,
-0.017579187,
-0.009294895,
0.04311023,
-0.0048668548,
0.0059239995,
0.0074665,
-0.000205175,
-0.037871048,
0.014959595,
-0.012486275,
-0.016515393,
-0.011209724,
0.005737836,
0.01864298,
0.016901018,
0.0047538267,
0.011375941,
-0.016315931,
-0.007074226,
-0.0056946194,
-0.0000038632634,
-0.00024413229,
0.03723277,
0.006499113,
0.017525997,
0.0074066618,
0.009328139,
0.012546114,
0.0031780829,
0.013197687,
-0.017951515,
0.039147597,
0.00073052687,
0.011641889,
0.00081986893,
-0.034520097,
-0.027897982,
0.0038662243,
-0.015012785,
0.010591393,
0.005179344,
0.022366257,
0.09324149,
-0.0010554825,
-0.036754064,
0.00041616763,
-0.01833714,
0.0052292095,
-0.012479627,
0.007905315,
-0.0020577754,
-0.030397898,
0.010006307,
-0.019640286,
0.008364076,
-0.024945956,
-0.03928057,
0.0035603836,
-0.006768386,
0.0057810526,
0.00065032684,
0.00005194304,
0.028084146,
0.012406491,
-0.017472807,
0.0066719796,
-0.04114221,
-0.014214939,
0.04659415,
-0.024852874,
-0.0007134896,
-0.04098264,
0.0032744892,
0.0041620918,
-0.009667222,
0.0016896032,
0.02240615,
-0.0008418928,
-0.020105695,
0.009341436,
0.025996452,
0.022419447,
0.0037897641,
0.028296905,
-0.012193732,
-0.015983496,
0.0064492477,
-0.0015408383,
-0.00829094,
-0.0031996912,
-0.015664358
] |
Gap junctions play a fundamental role in intercellular communication in cardiac tissue. Various types of heart disease including hypertrophy and ischemia are associated with alterations of the spatial arrangement of gap junctions. Previous studies applied two-dimensional optical and electron-microscopy to visualize gap junction arrangements. In normal cardiomyocytes, gap junctions were primarily found at cell ends, but can be found also in more central regions. In this study, we extended these approaches toward three-dimensional reconstruction of gap junction distributions based on high-resolution scanning confocal microscopy and image processing. We developed methods for quantitative characterization of gap junction distributions based on analysis of intensity profiles along | [
-0.03513867,
0.040816326,
0.007214809,
-0.026818419,
-0.020499738,
0.017006803,
-0.024319727,
0.005406201,
-0.009929356,
-0.0036564625,
-0.0028715332,
0.0036433805,
-0.01110675,
-0.015855573,
-0.002737441,
0.009334118,
0.03233909,
0.007456829,
-0.021978023,
0.00485348,
-0.037100993,
0.03524333,
-0.016038723,
-0.013840921,
-0.013317634,
0.040371533,
0.016431188,
-0.014861329,
-0.019701727,
-0.018537415,
-0.00424843,
0.019165358,
-0.03082156,
-0.008470696,
-0.004258242,
0.0041732076,
0.0054454473,
-0.0034962061,
0.017517006,
-0.018485086,
0.0076007326,
0.008830455,
-0.0035877812,
0.0016859629,
0.017739404,
0.019283097,
-0.0044806385,
-0.016365778,
-0.009517268,
0.027289378,
0.016496599,
0.0135007845,
-0.01316719,
-0.018982207,
-0.001416961,
-0.02306384,
0.00910518,
0.015122972,
-0.012853218,
-0.03610675,
-0.0040587387,
-0.018131869,
-0.026046572,
0.009399529,
-0.009301413,
0.014233385,
-0.012794348,
0.0076661436,
0.010400314,
-0.009654631,
0.020041863,
0.018589744,
-0.018393511,
0.008137101,
0.015934067,
-0.01911303,
-0.000084114174,
-0.013945579,
-0.025261642,
0.024005756,
0.007790424,
-0.028545264,
0.011080586,
0.027498692,
0.000013337667,
0.0064462326,
-0.0060243327,
0.0016197345,
0.019544741,
-0.019204605,
-0.0009051217,
0.018916797,
0.00007409815,
0.013075615,
-0.004873103,
0.0074502877,
-0.015947148,
0.03731031,
0.013906332,
-0.004631083,
-0.0015772175,
-0.008843537,
0.001416961,
-0.01699372,
-0.026491366,
-0.028990058,
0.009850863,
0.0028208399,
0.023103088,
-0.014573522,
-0.013697017,
0.024045002,
-0.024045002,
-0.009301413,
0.0062336475,
0.00008421638,
0.03320251,
-0.0046637887,
0.0025624672,
-0.0071493983,
0.021127682,
0.004114338,
0.016248038,
-0.019819466,
0.02312925,
0.02883307,
-0.0061191786,
0.006881214,
-0.0020588043,
-0.0056940084,
0.009863946,
0.021703297,
0.0048567504,
0.034144428,
-0.012820513,
-0.0068223444,
0.009497645,
-0.014167975,
-0.0031904108,
-0.031344846,
0.00035505788,
0.021166928,
0.0021700026,
-0.019152276,
0.01844584,
0.053113554,
0.02311617,
0.010773156,
0.022540554,
0.01170853,
0.010249869,
-0.011688907,
0.01692831,
-0.026138147,
-0.00041760693,
0.020669807,
-0.007927787,
0.029225536,
-0.020303506,
-0.010230246,
0.007881999,
-0.0052263215,
0.014468865,
0.009366823,
0.014481947,
0.011538462,
-0.00885662,
0.00035832843,
0.016823653,
-0.016287284,
-0.009046311,
0.024241235,
-0.013075615,
0.015122972,
0.015253793,
0.004071821,
-0.005170722,
0.01492674,
-0.021834118,
-0.031580325,
-0.014952905,
0.015031397,
0.0010473902,
0.0037055206,
-0.016117217,
0.002155285,
0.031789638,
0.0034536892,
0.013487703,
-0.019165358,
-0.0032165751,
0.016012559,
-0.01826269,
-0.017987965,
-0.63924646,
-0.0056285975,
0.00028760303,
-0.021925693,
0.0055501047,
0.040502355,
0.008052067,
0.008202512,
0.0005747972,
0.009654631,
-0.014691262,
0.031815805,
0.00049303373,
-0.0037480376,
-0.019165358,
-0.02615123,
-0.007940869,
-0.029618,
0.015698588,
-0.0018707484,
-0.022435898,
-0.0135007845,
-0.012460753,
0.02063056,
-0.009137886,
0.039952904,
0.028492935,
0.00013398989,
-0.016431188,
0.02810047,
-0.028545264,
-0.008483778,
-0.009327577,
-0.0036695448,
0.055416014,
0.013723182,
-0.009294872,
0.011878598,
-0.001110348,
0.03587127,
-0.010845107,
0.005327708,
0.025130821,
0.0046245423,
-0.02985348,
0.009870486,
0.005916405,
-0.006400445,
-0.008928572,
-0.016130298,
-0.020918367,
-0.01814495,
-0.03846154,
0.021219257,
0.014691262,
0.0043563577,
0.035766613,
0.015136055,
0.0281528,
0.012421507,
0.0136316065,
0.017804815,
-0.016091052,
-0.0064396914,
-0.0035485348,
0.001495454,
-0.010818943,
0.0027407117,
0.031135531,
-0.0015077185,
-0.0037676608,
0.026870748,
-0.00679618,
0.0061682365,
0.013670853,
0.027655678,
-0.008084772,
0.017255364,
-0.013644689,
0.018825222,
-0.020866038,
0.0015003597,
-0.032810047,
-0.0029712846,
0.027524857,
0.030795395,
-0.011937467,
0.025562532,
0.0033719258,
0.004526426,
0.0044773677,
0.0049254317,
-0.0015428768,
-0.054578755,
-0.026491366,
0.022566719,
-0.0037120618,
0.008967818,
-0.010897436,
0.005353872,
-0.010302198,
-0.009988226,
-0.013252224,
0.001741562,
-0.009399529,
0.025497122,
-0.033961277,
-0.009491104,
0.03403977,
-0.026622187,
-0.01886447,
-0.004284406,
-0.0038069075,
-0.010341444,
-0.0063317637,
-0.024437467,
0.020120356,
0.011682365,
-0.01098247,
-0.03118786,
0.012100995,
-0.01456044,
0.003954082,
-0.021951858,
0.025863422,
0.007489534,
-0.00073587126,
-0.020957613,
-0.015371533,
-0.0141156465,
-0.006802721,
-0.014691262,
0.025889587,
-0.00339809,
-0.0035910518,
0.0065083727,
0.014521193,
0.011388017,
-0.009929356,
-0.03657771,
0.0008936748,
0.0015502354,
0.014534275,
0.0054258243,
-0.0062042126,
0.012297227,
-0.044139195,
-0.019191522,
0.002676936,
-0.021441653,
-0.013212978,
-0.00206371,
-0.006299058,
0.0072475146,
0.026164312,
-0.0034013605,
0.00090266875,
-0.013082156,
-0.013867085,
-0.03689168,
0.01189168,
0.02226583,
-0.011211407,
-0.0019312532,
0.002616431,
-0.003950811,
-0.0062401886,
-0.019701727,
0.0011136185,
-0.015633177,
0.0012477107,
-0.006423339,
-0.026844583,
-0.0024659864,
-0.014638932,
0.011414181,
0.017006803,
-0.003257457,
-0.0048829145,
0.00032828035,
0.010485348,
-0.03246991,
-0.014338043,
-0.014416535,
0.024659865,
0.0006140437,
0.026726844,
0.009595761,
0.0011667648,
0.023835689,
-0.0007653061,
0.024424385,
-0.03343799,
0.00339809,
-0.0018347724,
-0.009929356,
0.011486133,
0.008470696,
-0.008804291,
0.026870748,
0.026766092,
-0.0093472,
0.0047063055,
-0.022239665,
0.016535845,
-0.0078165885,
0.0115057565,
-0.021873364,
0.019400837,
0.00094273285,
0.006783098,
0.01626112,
0.008411827,
-0.0152145475,
0.010289116,
0.014678179,
-0.01007326,
-0.0020800629,
-0.0136316065,
0.0026000785,
0.0072998432,
0.008751962,
0.01626112,
0.0045100735,
-0.00067168695,
0.0025085034,
0.014665097,
0.02014652,
0.0043857927,
-0.013880167,
0.002706371,
0.033594977,
-0.0006982601,
0.018288855,
0.0015404238,
0.006874673,
-0.004866562,
-0.0139848245,
0.029042386,
0.033333335,
0.023090005,
0.018537415,
-0.0054585296,
0.0112833595,
0.0030138018,
-0.0044675563,
0.02421507,
0.014638932,
0.007227891,
0.0065443483,
0.0138540035,
-0.00855573,
-0.0076007326,
0.0039181057,
0.005684197,
-0.010066719,
0.010818943,
0.008294087,
0.032731555,
0.010190999,
0.005975275,
-0.016012559,
-0.008745422,
-0.016483517,
-0.0032002225,
0.013605442,
-0.0020179225,
-0.009752748,
-0.021703297,
0.0109105185,
-0.0066457354,
0.014521193,
0.010989011,
-0.04866562,
-0.0054519884,
0.015175301,
0.006269623,
0.005236133,
0.015005233,
0.004866562,
-0.01849817,
-0.030429095,
0.003362114,
0.020604396,
-0.013644689,
-0.015763998,
-0.017464679,
0.012153323,
-0.02371795,
0.026556777,
0.010688121,
-0.0007595827,
0.01522763,
-0.02281528,
-0.018838305,
-0.005468341,
0.018537415,
0.0043073,
0.023861852,
0.00946494,
0.0030236132,
0.020290423,
-0.016614338,
-0.008928572,
0.038147565,
0.016679749,
0.0107796965,
0.015240712,
-0.004660518,
-0.01159079,
-0.011944008,
-0.022095762,
-0.004516614,
-0.0218472,
-0.0015077185,
-0.0027047358,
0.0067046047,
0.007868917,
0.04646782,
-0.004604919,
-0.018772895,
-0.046938777,
-0.017791731,
-0.03453689,
0.027786499,
0.017739404,
-0.008150184,
0.008091314,
0.004696494,
-0.015803244,
0.008810832,
-0.012264521,
-0.0045068027,
-0.016130298,
0.020538986,
-0.0115057565,
0.0140764,
-0.0028502748,
0.00026143872,
0.03670853,
-0.015986394,
-0.016051805,
0.0021471088,
0.006603218,
0.010563841,
-0.028362114,
0.017687075,
0.028911564,
0.027786499,
-0.008804291,
0.014952905,
0.013448456,
0.017817896,
-0.019950287,
0.0013360152,
0.02912088,
0.009772371,
-0.005000654,
-0.025641026,
-0.0034275248,
0.001826596,
-0.02488226,
0.024476714,
0.023220826,
0.010969387,
0.021310832,
0.0052263215,
0.00041351878,
0.0075680274,
-0.014364207,
0.0035191,
0.00081804354,
0.016653584,
0.0021389325,
0.04047619,
-0.017687075,
0.009942438,
-0.03712716,
0.014652015,
-0.024960754,
-0.013232601,
0.0016589809,
-0.014678179,
-0.012728938,
0.0008601518,
-0.021755625,
-0.0010547488,
-0.007129775,
-0.00915751,
-0.025798012,
-0.022919938,
-0.027210884,
-0.028806908,
-0.00021197181,
0.0029353087,
-0.028990058,
-0.019845631,
-0.01807954,
0.043380428,
0.0154761905,
0.019845631,
0.012872841,
0.0004979396,
0.0042745946,
0.0015126243,
-0.0008969453,
-0.009981685,
-0.013363422,
-0.0112899,
-0.013579278,
-0.012048665,
-0.031894296,
0.015659342,
-0.005625327,
0.01856358,
-0.03330717,
0.0052230507,
-0.00033809198,
0.0032378335,
0.026739927,
0.016967556,
-0.0066947932,
-0.002572279,
-0.013114861,
-0.018354265,
-0.03663004,
-0.0116562005,
-0.04751439,
-0.010975929,
-0.023168499,
-0.0061322604,
0.023050759,
0.00637101,
0.014167975,
-0.0028568157,
-0.032182105,
0.021441653,
0.0225798,
0.040057562,
0.02718472,
0.026569858,
0.014534275,
-0.015554683,
-0.01966248,
0.0063252226,
-0.009667713,
0.018720565,
-0.014704343,
-0.02468603,
0.017687075,
-0.0059000524,
-0.03725798,
-0.026190476,
-0.013396128,
0.00010424843,
0.036787022,
0.004987572,
-0.03772894,
-0.018655155,
0.0022125195,
0.010642334,
0.0027537937,
-0.0016091052,
-0.004398875,
-0.020028781,
0.014416535,
-0.00910518,
-0.03301936,
0.018341182,
-0.039534274,
-0.009007065,
0.004009681,
0.008202512,
0.00048731032,
-0.0037153324,
0.0046997643,
-0.013193354,
-0.0039115646,
-0.015750917,
-0.034196757,
-0.017517006,
-0.028440608,
0.02475144,
0.054212455,
0.023979591,
-0.0025951727,
0.020002617,
0.022121925,
-0.005380037,
-0.0045951074,
0.012539246,
0.016718995,
-0.015842492,
0.03663004,
0.009209838,
0.014913658,
0.019152276,
-0.020342752,
0.02506541,
0.02014652,
-0.00032378337,
0.0020915098,
0.0067046047,
-0.030350601,
-0.008608059,
-0.00065083726,
0.0008298993,
-0.0029238618,
-0.055729985,
-0.0035746992,
0.016169544,
-0.011172161,
-0.009791994,
-0.014822083,
0.008444532,
-0.01874673,
0.029094715,
-0.018288855,
0.007312925,
0.0017382915,
-0.018118786,
-0.023744114,
-0.01219257,
0.010125589,
0.013762428,
0.012787808,
0.0034863946,
-0.015907902,
0.0071166926,
0.004375981,
-0.04769754,
0.0034569597,
0.0026703952,
-0.03464155,
-0.0076661436,
-0.02403192,
-0.012630821,
-0.031344846,
0.011316065,
0.011806645,
-0.02324699,
0.016862899,
0.0018756541,
0.013540031,
0.008359497,
0.020434327,
0.0072475146,
-0.02384877,
0.018982207,
0.0013621795,
-0.01704605,
-0.017870225,
-0.015528519,
-0.0041110674,
0.011008634,
0.023534799,
-0.013827839,
-0.013867085,
-0.006985871,
0.011636578,
0.016980639,
-0.006505102,
-0.030952381,
0.014338043,
0.01753009,
-0.025143905,
-0.020931449,
0.0049254317,
-0.031109367,
-0.0028126636,
0.007293302,
-0.0038036369,
0.00503663,
-0.018589744,
-0.021624804,
0.036970172,
0.0037938252,
0.03513867,
0.021336997,
-0.006724228,
-0.013154108,
-0.008470696,
-0.006462585,
0.0031560701,
0.012905546,
0.013683935,
-0.011911303,
0.01801413,
0.017791731,
0.0039638933,
-0.01007326,
-0.009955521,
-0.0034373365,
0.046389326,
-0.018171115,
-0.015633177,
0.022017268,
-0.0036760857,
0.028963894,
-0.003288527,
-0.004392334,
-0.025013082,
-0.027315542,
-0.018432757,
0.017163789,
0.0043073,
0.020225013,
-0.009687336,
-0.0040031397,
-0.010609629,
-0.04356358,
-0.003391549,
0.00029741463,
-0.040973313,
-0.041810572,
-0.011080586,
0.013029828,
0.009955521,
-0.008195971,
0.0080782315,
-0.012251439,
0.028492935,
-0.017569335,
0.025536368,
0.0042680535,
0.009628466,
-0.023704866,
0.0031086474,
-0.013350341,
-0.017124543,
0.008483778,
-0.03008896,
-0.02718472,
-0.027106227,
-0.018485086,
0.027577184,
-0.015620094,
0.002475798,
0.0018020669,
-0.011963632,
0.005072606,
0.019701727,
-0.010897436,
0.021938775,
-0.030167451,
0.0057626897,
0.012853218,
-0.020695971,
0.0023286238,
-0.019361591,
-0.027237048,
0.015463108,
-0.016823653,
-0.020957613,
-0.0355573,
-0.004071821,
-0.008124019,
-0.0104068555,
-0.0012501635,
-0.005860806,
-0.02943485,
0.026530612,
0.0017857143,
0.011388017,
0.011420722,
0.009909733,
0.0175955,
0.032548405,
-0.019570906,
-0.0025264914,
0.014861329,
-0.013683935,
-0.012120618,
-0.013644689,
-0.010746991,
0.012421507,
0.012951334,
-0.011551544,
0.0004118835,
-0.012702773,
-0.044950288,
-0.015358451,
0.002791405,
-0.0017431973,
-0.011244113,
0.030193616,
0.003610675,
0.018877551,
0.005020277,
0.007790424,
-0.005939299,
-0.008594977,
0.025222396,
-0.010099424,
0.023390895,
0.010570382,
-0.04107797,
-0.009641549,
0.029330194,
0.003525641,
0.0019982993,
0.0066097593,
-0.0052165096,
0.013003663,
-0.0026916536,
0.00485348,
-0.00017313416,
-0.0053015435,
0.02439822,
-0.017032968,
0.0016025641,
0.01736002,
0.007842752,
-0.019583987,
0.011093669,
-0.011139456,
0.019950287,
0.00013838468,
-0.0060276035,
-0.018916797,
0.029042386,
-0.018354265,
-0.0037251438,
0.013095238,
-0.024895342,
0.017582418,
0.02378336,
0.022488225,
0.009530351,
-0.012087912,
-0.012087912,
0.015737833,
0.016117217,
-0.0069335424,
-0.028990058,
-0.0066163004,
0.01504448,
-0.0218472,
-0.011178702,
-0.0001694548,
-0.014848247,
-0.03100471,
0.021677133,
0.007312925,
0.0074829934,
-0.013945579,
0.0016221873,
-0.012604658,
-0.013330717,
0.009628466,
0.00873888,
-0.017804815,
0.014050235,
-0.0042974884,
-0.002719453,
0.010786237,
-0.018249607,
-0.0142464675,
-0.0030497776,
-0.0042059133,
0.19016221,
-0.026111983,
-0.013186813,
0.007142857,
-0.0004541961,
-0.00077797944,
-0.00055149465,
0.0075353216,
-0.00618786,
0.019217687,
0.008405285,
-0.012225275,
-0.015711669,
-0.010001308,
0.02651753,
-0.019937206,
-0.01844584,
-0.0022942831,
-0.010498431,
0.0115057565,
0.010858189,
-0.015083726,
0.019845631,
0.0019247122,
0.03472004,
-0.027864993,
-0.021834118,
0.0026229722,
0.026399791,
0.011008634,
-0.0072605964,
0.0031446232,
-0.013042909,
0.0096807955,
0.014024071,
-0.001501995,
-0.0055664573,
0.0025395735,
0.017804815,
-0.00443158,
0.008091314,
-0.00052083336,
-0.0066849818,
0.000114264454,
0.011211407,
0.018668236,
0.0005110217,
-0.017503925,
0.010655416,
0.0019852172,
-0.050026163,
0.006272894,
-0.0022076138,
0.03362114,
-0.019871796,
-0.0005735708,
0.004166667,
0.017791731,
0.003993328,
0.012565411,
-0.026177393,
0.009366823,
-0.0032770801,
0.036080588,
-0.02166405,
0.022828363,
-0.0010719191,
0.009085557,
-0.0009108451,
-0.0001506492,
0.012035583,
-0.015188383,
-0.023194663,
-0.00922292,
-0.023992674,
-0.008483778,
0.053689167,
-0.0052884617,
0.0059294873,
0.006966248,
0.015816327,
-0.029173208,
-0.0057005496,
-0.005066065,
-0.0002489698,
-0.029696494,
0.03063841,
0.021860283,
-0.0016450811,
-0.011688907,
-0.0101648355,
0.0068550496,
-0.0080782315,
-0.014024071,
0.009818158,
-0.0051183933,
-0.00003247543,
0.0055075875,
-0.007044741,
0.022710623,
0.0026393249,
0.066718996,
0.021716379,
0.0021978023,
-0.0032198457,
-0.005353872,
-0.028074307,
0.012323391,
-0.008608059,
-0.00068599556,
0.0012918629,
-0.03689168,
0.0089351125,
-0.014050235,
-0.013271847,
0.017307693,
0.042700157,
-0.030193616,
0.03427525,
-0.012231816,
-0.010269493,
0.00012070333,
0.0059687337,
0.02870225,
-0.025261642,
-0.020538986,
-0.010903977,
0.018602826,
0.003149529,
-0.029330194,
-0.0008311257,
-0.009720041,
-0.011388017,
0.000053044056,
0.023652539,
0.009392988,
0.009981685,
0.021350078,
-0.004660518,
0.011675824,
-0.0033245028,
-0.0061616953,
0.015332287,
0.033778127,
0.008392203,
-0.0281528,
0.024306646,
-0.020525903,
0.015894819,
-0.010504971,
0.0048011513,
-0.015724752,
-0.0037513082,
-0.0022942831,
0.023574045,
-0.012545788,
-0.00052124215,
-0.020028781,
-0.0010416667,
-0.009065934,
-0.009013605,
0.0075876503,
0.016012559,
-0.007136316,
-0.0033179617,
0.0102956565,
-0.16336997,
0.025104657,
0.028257458,
0.00862114,
-0.0031609759,
0.007018577,
0.00625,
-0.004640895,
-0.006959707,
0.021559393,
0.02312925,
-0.01959707,
-0.00031662907,
-0.011839351,
0.01644427,
0.004909079,
-0.0041601257,
0.032783885,
0.011368394,
0.008084772,
0.028126635,
-0.0253663,
0.029748823,
-0.028205128,
0.018576661,
0.009975144,
-0.016849818,
0.009746206,
-0.009896651,
-0.020133438,
-0.0038330718,
0.00055640045,
0.043903716,
-0.013618524,
0.0076530613,
-0.007842752,
-0.007986656,
-0.022409733,
0.0046736,
0.01596023,
0.02810047,
0.027132392,
-0.020722136,
-0.019989533,
-0.029984301,
-0.007960492,
-0.015279958,
-0.029539509,
0.02985348,
0.0011046246,
0.00831371,
-0.0059327576,
-0.0028208399,
0.040397696,
0.01395866,
0.01298404,
-0.011800105,
0.030429095,
0.0020620748,
-0.016130298,
-0.0135007845,
-0.012944793,
0.01881214,
0.015450026,
-0.0027619703,
-0.028676085,
-0.0144427,
-0.020329671,
-0.040816326,
0.020918367,
-0.015816327,
-0.01868132,
0.013317634,
-0.031423338,
0.036263738,
0.026242806,
0.0016597986,
0.002961473,
-0.011231031,
-0.005435636,
-0.014573522,
0.015279958,
-0.026753008,
-0.03854003,
-0.01711146,
-0.008379121,
0.0002747253,
0.022383569,
-0.015253793,
0.0069727893,
0.023770276,
-0.03914181,
0.0042124544,
-0.005563187,
0.028021978,
0.013553114,
-0.0022991889,
-0.023587126,
-0.0038461538,
-0.0077708005,
0.012957876,
-0.0003620078,
0.003538723,
0.013566196,
0.021703297,
-0.001392432,
0.025641026,
0.013723182,
0.04994767,
-0.003075942,
-0.012087912,
-0.029461015,
-0.009543433,
0.03537415,
0.010531136,
0.012310308,
0.016051805,
-0.012421507,
0.03956044,
-0.031841967,
0.05928833,
-0.007914704,
-0.014037154,
0.020852957,
-0.01474359,
-0.025209315,
-0.12244898,
-0.020617478,
0.030873887,
0.040240712,
0.003239469,
0.0015494179,
-0.008791209,
0.020787546,
-0.014534275,
0.04696494,
-0.03210361,
-0.0034798535,
0.009373365,
-0.025824176,
0.009955521,
-0.018537415,
-0.011414181,
0.003196952,
-0.014939822,
0.032757718,
-0.020185767,
-0.025719518,
-0.0062892465,
-0.018158032,
0.007927787,
-0.0008658752,
-0.025274726,
0.03021978,
0.011172161,
-0.011355312,
0.020957613,
0.00203264,
-0.00019173535,
-0.009007065,
-0.009425693,
-0.02269754,
0.019374672,
-0.01929618,
0.040607013,
-0.023037676,
-0.010969387,
0.029879645,
0.031083202,
-0.0046736,
-0.0031086474,
0.00035689757,
-0.036080588,
0.015149137,
-0.008640764,
-0.0053048143,
-0.017255364,
-0.00038551478,
-0.018851386,
-0.0067438516,
0.04489796,
-0.003028519,
-0.00052124215,
0.0055370224,
-0.019453166,
-0.0024022108,
0.009569597,
-0.00037611197,
-0.01110675,
0.0035877812,
0.032731555,
-0.013605442,
-0.039089482,
-0.028205128,
0.03265306,
-0.02341706,
-0.00046809588,
0.012264521,
-0.016732078,
0.0016450811,
-0.01911303,
0.0025281266,
-0.0019590529,
0.0012460754,
0.0062827053,
-0.0046539768,
-0.013540031,
-0.022488225,
0.031894296,
0.015515437,
0.032574568,
0.0049777604,
-0.01814495,
-0.00873888,
0.021677133,
-0.0056874673,
-0.0086930925,
0.039167974,
0.0013294742,
-0.005798666,
-0.010236787,
0.010890895,
-0.002166732,
-0.005023548,
-0.011034799,
0.0005956469,
-0.036446888,
-0.0077380952,
-0.040607013,
0.021415489,
0.00862114,
0.011937467,
0.012702773,
-0.023495551,
0.0074110413,
-0.012970958,
0.026465202,
-0.0072605964,
-0.007849294,
0.010956306,
0.003555076,
-0.023940345,
-0.041470435,
-0.03440607,
0.032234434,
0.018785976,
0.018354265,
0.030167451,
-0.0076596024,
0.003021978,
-0.017517006,
0.01917844,
0.0101648355,
-0.0033719258,
-0.016012559,
0.003082483,
-0.025588697,
-0.021912612,
0.008536107,
-0.023770276,
0.00079678505,
0.0025052328,
-0.0028502748,
-0.014939822,
-0.023574045,
0.031632654,
0.005667844,
0.0152145475,
-0.022841444,
-0.022789115,
0.00958922,
0.018092621,
0.0014324961,
0.00046073718,
-0.035400312,
-0.00067168695,
-0.0061486135,
-0.0239011,
0.01868132,
0.006668629,
-0.011113292,
-0.016967556,
-0.035531137,
0.026425956,
0.010949764,
0.0073587126,
0.013736264,
-0.009092098,
0.025719518,
0.014573522,
-0.0072998432,
0.022710623,
0.0145996865,
-0.029042386,
-0.010138671,
-0.006802721,
0.010393773,
-0.011486133,
-0.023338566,
-0.0127551025,
0.0012918629,
0.018158032,
-0.01947933,
0.018916797,
-0.00928179,
0.010452643,
0.0049614077,
0.0041535846,
0.033281006,
-0.0025837258,
-0.014298797,
0.009065934,
0.021088436,
-0.006881214,
0.00903977,
0.031397175,
-0.002323718,
0.00764652,
-0.002676936,
0.03356881,
0.0004423404,
0.02493459,
-0.027053898,
0.053453688,
-0.0064952904,
0.009079016,
0.0041961013,
0.015541601,
-0.019387756,
0.019453166,
-0.012859759,
-0.027995814,
-0.0172292,
0.0029925432,
-0.010773156,
-0.05028781,
-0.020748299,
0.01868132,
0.025039246,
-0.0018969126,
0.020002617,
-0.0098116165,
-0.014965987,
0.0029320382,
0.00862114,
-0.012284145,
-0.03118786,
0.010354526,
0.017124543,
0.0053669545,
-0.035034012,
0.000879775,
0.011145997,
0.00813056,
0.024175825,
-0.007541863,
0.009059393,
-0.00035628435,
0.025588697,
-0.008575353,
-0.0038984825,
-0.008948195,
0.0076596024,
-0.007437206,
-0.0072540552,
0.017137624,
-0.017006803,
0.070800625,
0.0023891288,
0.004758634,
0.0069989534,
-0.032417584,
0.011388017,
-0.0070839874,
0.013710099,
-0.01904762,
-0.06907378,
0.004496991,
-0.02244898,
0.0057561486,
-0.025340136,
-0.008274464,
0.029879645,
-0.0022664836,
0.010465724,
-0.01225798,
0.0021650968,
0.02251439,
-0.03950811,
-0.002093145,
0.009576138,
-0.020172685,
-0.022462063,
0.018171115,
-0.00221579,
0.0034275248,
0.01711146,
0.026085818,
-0.015855573,
-0.044950288,
-0.014822083,
0.0077577187,
0.005327708,
0.00011896586,
-0.023560964,
-0.0034177133,
0.005772501,
-0.014311879,
0.028205128,
-0.027603349,
-0.011970173,
-0.018615907,
0.011878598,
-0.030115124,
0.0014455782,
-0.029827315
] |
Embryonic stem (ES) cell lines derived from human blastocysts have the developmental potential to form derivatives of all three embryonic germ layers even after prolonged culture. Here we describe the clonal derivation of two human ES cell lines, H9.1 and H9.2. At the time of the clonal derivation of the H9.1 and H9.2 ES cell lines, the parental ES cell line, H9, had already been continuously cultured for 6 months. After an additional 8 months of culture, H9.1 and H9.2 ES cell lines continued to: (1) actively | [
-0.011881514,
-0.01989005,
-0.017645033,
-0.024025604,
-0.016253386,
0.004860918,
-0.006833512,
0.012964636,
-0.032401744,
0.0035119392,
-0.016069584,
-0.0050775423,
0.007155166,
0.008395832,
-0.0226996,
0.0049856408,
0.019627474,
-0.00106589,
0.012853041,
0.0183146,
-0.015623206,
-0.007975712,
0.004772299,
-0.013365063,
-0.0054188897,
0.0149273835,
0.0001492369,
-0.013850826,
-0.012137525,
0.0029539675,
0.014914255,
0.02448511,
-0.0068006897,
-0.0005165341,
-0.024222534,
-0.017001726,
-0.0018888982,
-0.0053499634,
0.015426275,
0.017986381,
0.016712893,
-0.0014663168,
-0.024878971,
-0.0065315505,
-0.008763437,
0.0032723397,
-0.0067087887,
-0.01538689,
-0.010850908,
0.025259705,
0.03211291,
0.011467959,
-0.015242473,
0.02248954,
-0.031850334,
0.0020841884,
-0.0029654554,
0.01349635,
0.009977846,
0.006009683,
0.008028228,
0.0001405186,
-0.010325758,
0.0068466407,
-0.0183146,
0.021281695,
-0.0069647995,
0.0034627065,
0.011441701,
0.0006219743,
0.028069258,
-0.0047690165,
-0.007883811,
-0.021478627,
0.005635514,
-0.0037974895,
-0.015649464,
-0.0074636918,
0.011678019,
0.010942809,
0.006482318,
-0.03799459,
-0.017329944,
0.018905394,
-0.0023516864,
0.015557563,
0.0031689508,
0.007962584,
0.0017953559,
-0.004860918,
0.0464495,
0.022725858,
0.007437434,
0.008428655,
-0.036550425,
-0.0032674165,
-0.0011085584,
0.038624767,
-0.009721836,
-0.03838845,
-0.013253468,
0.013082795,
-0.02031017,
-0.023172235,
-0.044270128,
0.00026688277,
0.03429228,
-0.016883567,
0.019325513,
-0.016043326,
0.008290802,
0.008198901,
0.017513746,
-0.03618282,
0.037705757,
0.008986626,
0.012367278,
-0.0028423732,
-0.006498729,
0.0031492577,
0.0037121526,
-0.0028801186,
0.002734061,
-0.026625095,
0.025364736,
0.033767134,
-0.016607862,
-0.0027045214,
-0.012892428,
-0.008927546,
0.0075358995,
-0.01505867,
0.010365144,
0.006748175,
-0.02990728,
0.00046114717,
-0.02145237,
-0.009380489,
0.0035841474,
-0.019509315,
-0.000021244463,
0.011750227,
0.007818168,
0.024524495,
-0.009459261,
0.00076392887,
0.009026012,
0.005907935,
0.0038828263,
0.011828999,
0.004463773,
-0.0022991714,
0.03715435,
-0.014494135,
0.0043653077,
0.018774105,
0.029119557,
0.0031689508,
-0.018760977,
0.006288669,
-0.026401907,
-0.004194634,
0.020835318,
-0.0007126447,
0.013200954,
0.030511204,
-0.010483303,
0.011047839,
-0.0004160171,
0.008152951,
-0.015990812,
0.01444162,
-0.021071635,
0.008822517,
-0.00926233,
0.005458276,
-0.0058718314,
0.012649545,
-0.037679497,
-0.02406499,
-0.011645197,
0.017027982,
0.033399526,
0.019732503,
-0.023802415,
0.007155166,
0.0131221805,
-0.006623452,
-0.0023303523,
-0.0064888825,
-0.015045542,
-0.011376058,
0.03064249,
-0.00094362855,
-0.6398425,
-0.036891773,
0.016699763,
-0.0194568,
0.008993191,
0.019338641,
0.0103520155,
-0.0013809799,
-0.028489377,
-0.00011508165,
-0.023356037,
0.004089604,
0.005622385,
-0.002484615,
-0.006377288,
-0.023145977,
-0.006623452,
0.00030934607,
0.03838845,
-0.007155166,
-0.011861822,
-0.0062098964,
-0.013509478,
0.020861575,
-0.0036694843,
0.00747682,
0.02082219,
-0.010273243,
-0.023237878,
0.02741282,
-0.011290721,
0.013456964,
0.00051858544,
0.0035841474,
0.03736441,
0.013233775,
-0.009137606,
0.017316815,
0.0073061464,
0.047447287,
0.0051891366,
0.007030443,
0.008829081,
0.0011930747,
-0.022568313,
0.010621155,
0.005461558,
-0.005711004,
-0.003679331,
-0.009131042,
0.026270619,
-0.004385001,
-0.01570198,
-0.009137606,
-0.002555182,
-0.005625667,
0.028148029,
0.008041357,
0.015294988,
-0.0030803317,
0.005458276,
0.019364899,
-0.018747848,
-0.001655863,
-0.015951425,
0.027701652,
-0.014612293,
-0.004385001,
0.006101584,
-0.026506936,
0.008297367,
0.033241984,
-0.0052055474,
-0.0237499,
-0.008323625,
0.035526384,
-0.0001913925,
-0.017920736,
0.0070041856,
0.0034495778,
-0.0043948474,
-0.015281859,
-0.002835809,
0.033005666,
0.011979979,
-0.012268812,
-0.013036844,
0.009321409,
-0.017540004,
0.014428491,
0.003541479,
0.016988596,
0.016686635,
-0.048917703,
-0.0052777557,
0.008008534,
-0.010686799,
0.0013686717,
0.0046803975,
-0.032165427,
-0.014782967,
0.007076394,
0.029067041,
0.01088373,
0.015925167,
0.014152788,
-0.03192911,
0.020848447,
0.027491592,
-0.028830724,
0.0041880696,
0.0048740464,
-0.0051760077,
-0.002906376,
0.014914255,
-0.026270619,
-0.0041880696,
0.020664645,
-0.015807008,
-0.028778208,
0.018629689,
-0.018288342,
-0.0062952335,
0.004916715,
0.0023385577,
0.026913928,
-0.007398048,
-0.010706492,
-0.01004349,
-0.016030198,
-0.015662594,
0.011323542,
-0.0022318866,
-0.03788956,
0.024892101,
0.017815707,
0.011152869,
0.0018363832,
0.011362929,
-0.0053105773,
-0.035001233,
0.0018626407,
-0.0033675232,
-0.009459261,
-0.007260196,
-0.008428655,
0.0008045459,
-0.004480184,
0.00926233,
-0.02427505,
0.014087143,
0.013561994,
-0.0058882423,
0.0113038495,
0.026310004,
-0.00514975,
-0.011461395,
-0.031298928,
0.006026094,
-0.023487326,
-0.022016905,
0.011205384,
-0.0029047348,
0.01757939,
0.008927546,
-0.0009707066,
-0.010023797,
-0.005162879,
-0.012603595,
-0.03234923,
-0.003505375,
0.0033002384,
-0.0038270291,
0.011271028,
0.0035217858,
0.010457045,
-0.015964555,
-0.009058834,
-0.021229181,
0.00012841554,
0.00193649,
-0.011120047,
-0.002007057,
-0.0049757943,
0.041670635,
0.00050340535,
0.019102324,
0.011953723,
0.026310004,
0.014481006,
0.0002574465,
0.015163701,
-0.020966606,
0.011651761,
0.008927546,
-0.027701652,
-0.0065085753,
0.0073914835,
0.024393208,
0.03292689,
0.036130305,
0.012393535,
0.0012341021,
0.0008369575,
0.009249201,
-0.032060396,
-0.016371544,
-0.012721754,
-0.00007959302,
0.023369167,
-0.0036596376,
-0.0009165505,
-0.002025109,
-0.014572907,
0.002960532,
-0.03423977,
-0.015294988,
-0.010174777,
-0.0098728165,
-0.0066168876,
0.0054188897,
-0.008619021,
0.026559452,
0.0025683108,
-0.0046246005,
0.00926233,
-0.0018183312,
0.018498402,
0.00009077296,
0.0014917536,
0.009163864,
0.01810454,
0.0012119473,
0.012492001,
0.009931896,
0.01894478,
0.031666532,
-0.020520229,
0.02919833,
0.003068844,
-0.011848693,
0.010220728,
-0.00014205712,
0.016135227,
-0.006538115,
-0.0043259216,
0.03505375,
-0.0034069093,
-0.026047431,
0.020992864,
-0.028121771,
0.00926233,
-0.008559942,
0.014874868,
-0.00033888573,
-0.010909988,
-0.012157218,
0.010995324,
0.008697794,
0.010713056,
0.012485436,
-0.024209406,
-0.0041650943,
-0.007522771,
0.0131221805,
-0.007916633,
0.003295315,
-0.0020825472,
-0.022043163,
-0.017408716,
-0.029093299,
0.009446132,
0.0024599987,
-0.01882662,
-0.004772299,
0.010430788,
0.01538689,
-0.0041618124,
0.027911711,
0.00052145735,
-0.029854767,
-0.011730534,
0.017500617,
0.02406499,
0.008172643,
0.010818086,
-0.014481006,
-0.036760487,
0.0015992452,
0.009439568,
0.010273243,
-0.0107787,
0.0036169693,
0.0045195706,
-0.022463283,
-0.017750064,
-0.013903341,
-0.0025502588,
0.03830968,
0.011448266,
0.0071748593,
-0.015019285,
-0.005930911,
-0.010516125,
0.032611802,
0.008152951,
0.00292771,
-0.027360305,
0.011238206,
-0.03064249,
-0.021504885,
-0.024327565,
-0.016502833,
0.015137443,
-0.010056619,
-0.010923116,
0.008756873,
0.0011298927,
0.031771563,
-0.025023388,
-0.01176992,
-0.004050218,
-0.0027504722,
-0.020848447,
0.02385493,
0.017382458,
0.0007737754,
0.015111186,
0.013627637,
-0.0023763028,
-0.022660214,
-0.005317142,
0.01265611,
0.0014605729,
-0.0076212366,
-0.009951589,
0.0077065732,
-0.010424224,
-0.010660541,
0.027281532,
-0.007910069,
-0.005005334,
0.008927546,
-0.006049069,
-0.0027045214,
0.010417659,
0.021071635,
0.037285637,
0.015833266,
-0.006134406,
0.031246413,
0.013995242,
-0.012098138,
-0.0008258801,
-0.017290557,
0.018078282,
-0.00450316,
0.010470174,
0.01767129,
-0.022345124,
0.0052449335,
-0.0030704853,
0.0016476575,
0.010437353,
0.009347666,
0.012958071,
-0.019194225,
-0.00620005,
-0.002727497,
0.002835809,
-0.02271273,
0.0032329534,
0.0011832281,
-0.025666697,
0.019194225,
-0.024629526,
-0.030511204,
0.0010059901,
-0.00085090677,
0.007575286,
-0.013942727,
-0.010312629,
-0.0041092974,
-0.01810454,
-0.01062772,
-0.030406173,
0.033635844,
0.020493971,
0.0049101505,
-0.04130303,
-0.0045228526,
-0.00507426,
-0.018143926,
-0.00507426,
0.010358579,
-0.0044178227,
-0.037521955,
-0.0011988186,
-0.010772135,
0.02292279,
-0.004427669,
-0.009498647,
0.0068138186,
0.025496023,
-0.0035841474,
-0.016240258,
0.0017067369,
-0.015964555,
0.0035808652,
0.02082219,
0.018393371,
-0.02301469,
-0.027649136,
-0.001525396,
0.019693118,
-0.013148438,
-0.016017068,
0.0030032005,
-0.023447938,
0.008500863,
0.020218268,
0.00457865,
-0.004988923,
-0.0010502996,
-0.022738986,
-0.02478707,
-0.02457701,
-0.004322639,
-0.000022500926,
-0.0082514165,
-0.0061540995,
0.0007155166,
-0.017014854,
-0.01333224,
0.008395832,
-0.002059572,
0.006393699,
-0.009800608,
0.01282022,
0.011612375,
0.0092098145,
0.004949537,
0.006767868,
0.0005448429,
0.011376058,
-0.004956101,
0.04897022,
-0.0033560356,
-0.022082549,
-0.008940675,
0.017868223,
0.002450152,
-0.024865843,
0.0029949949,
-0.00800197,
0.02573234,
-0.010489867,
-0.0068269474,
-0.013732667,
-0.00026893415,
0.011336671,
0.03200788,
0.011999673,
-0.011540167,
0.021176666,
0.013128745,
0.004988923,
-0.0035611722,
0.0031755152,
-0.03694429,
-0.016292773,
0.035920247,
-0.012091574,
0.0013432347,
-0.014139659,
0.0068138186,
-0.01852466,
-0.021294825,
-0.014901126,
-0.014625422,
0.0022876838,
-0.016108971,
0.02741282,
0.04350866,
0.010896859,
-0.012275376,
0.035552643,
0.027386563,
0.018432759,
-0.005793059,
-0.003987856,
0.026848285,
-0.015334374,
0.037915815,
0.004138837,
-0.004145401,
0.005812752,
-0.013378191,
0.01881349,
0.051832285,
-0.010201035,
-0.005130057,
-0.001990646,
-0.047027163,
-0.033136953,
-0.0060687624,
-0.0059670145,
0.007877247,
-0.013168131,
-0.012984329,
0.009748093,
-0.0014072374,
-0.013877084,
-0.0056781825,
0.024931487,
-0.013758925,
0.005477969,
-0.015820138,
0.0056158206,
-0.012334456,
0.002079265,
-0.023907445,
-0.008710923,
0.012130961,
0.0043587433,
0.018262085,
0.02772791,
-0.020599,
0.011934029,
0.013798311,
-0.014507263,
-0.013890212,
-0.016069584,
-0.01705424,
0.0003124231,
-0.011264463,
-0.014481006,
-0.010942809,
-0.008448347,
0.018787235,
-0.0036136871,
0.021675559,
-0.016161485,
-0.0033576766,
0.020323297,
-0.018760977,
0.047315996,
-0.011441701,
0.019509315,
0.030931324,
0.0055107907,
-0.016463445,
-0.01987692,
0.0026897516,
0.009931896,
0.015268731,
0.011336671,
0.0013522607,
-0.041906953,
0.010102569,
0.040515307,
-0.027780425,
-0.029067041,
0.010214164,
-0.005970297,
-0.009754658,
-0.008986626,
-0.007785346,
-0.007824732,
-0.0044506444,
-0.018564045,
0.035920247,
0.007837861,
0.01229507,
-0.012629853,
0.033977192,
-0.012314763,
0.020060722,
0.0063641593,
0.01622713,
-0.025548538,
-0.040830396,
-0.016450318,
0.0008492657,
0.0071092155,
0.038966116,
-0.029145814,
-0.0115007805,
0.01809141,
-0.0077393954,
-0.011415444,
-0.004929844,
0.0034233204,
0.03211291,
-0.015150572,
-0.01568885,
0.009459261,
0.014087143,
0.022358254,
-0.02217445,
-0.011231641,
-0.010667105,
-0.036314107,
-0.011828999,
0.044769023,
0.012787398,
0.010857472,
-0.026441293,
-0.030616233,
-0.0011651762,
-0.036996804,
-0.043167315,
-0.002555182,
-0.02867318,
-0.0020710595,
0.027255274,
0.020428328,
0.023159107,
-0.029145814,
-0.005917782,
0.0033494711,
0.020480843,
-0.00055797165,
0.025338478,
0.0147435805,
0.00863215,
-0.032139167,
0.004178223,
-0.0049626655,
-0.018393371,
0.000026539554,
-0.033084437,
-0.029749736,
-0.029592192,
0.003751539,
0.018052025,
-0.0019611062,
0.0017559696,
0.009853123,
0.021623043,
0.025916142,
0.00213178,
-0.018682204,
0.015649464,
-0.016489703,
-0.01778945,
-0.0009567573,
-0.025601054,
0.010890294,
-0.008015099,
-0.015229344,
-0.0334783,
-0.0058193165,
-0.008822517,
-0.00056904904,
-0.005671618,
-0.012019366,
0.0065118577,
-0.0058718314,
-0.02008698,
-0.013772054,
0.0068991557,
0.0025338477,
-0.016568476,
-0.021084765,
0.0053729387,
0.016975468,
0.036655456,
0.004181505,
-0.010023797,
-0.0111134825,
-0.02436695,
-0.027701652,
0.0047165016,
-0.0020349554,
0.03547387,
0.020126367,
-0.005461558,
-0.013522607,
-0.0103520155,
-0.044296388,
-0.024327565,
0.008848774,
0.014612293,
0.028830724,
0.032375485,
0.001489292,
-0.010450481,
-0.009360795,
0.017868223,
-0.021898746,
-0.024051862,
0.017750064,
-0.023277266,
0.014284074,
0.006886027,
-0.031640276,
0.0124001,
0.018367114,
-0.0072864536,
-0.0016279644,
0.009931896,
0.0014392387,
0.030327402,
0.03085255,
0.03389842,
0.0063346196,
0.033005666,
-0.002412407,
-0.03182408,
-0.010798393,
0.0022991714,
-0.014428491,
-0.010818086,
-0.020231396,
-0.02510216,
-0.014901126,
-0.00005297654,
-0.003469271,
-0.01187495,
-0.0073914835,
-0.0008689588,
0.012222862,
0.00052309845,
0.013292855,
0.017119884,
0.034266025,
0.009360795,
-0.007155166,
-0.0011553295,
-0.0019807995,
0.0038434402,
-0.00066382217,
-0.011330107,
0.009255765,
-0.012885863,
-0.020493971,
-0.035526384,
-0.0067350464,
0.0030032005,
-0.016502833,
-0.025535408,
0.023736771,
0.0049987696,
-0.02248954,
-0.008244852,
0.012951507,
-0.021885619,
-0.011756791,
0.010457045,
-0.0014884715,
-0.029434647,
0.0033937807,
-0.012071881,
-0.0011758432,
-0.02436695,
0.016279643,
0.0030589977,
-0.0056814644,
0.010877165,
0.19230986,
-0.0063477485,
0.003961599,
0.022305738,
-0.0050873887,
-0.025482895,
-0.006190203,
0.022568313,
-0.004017396,
-0.0050512846,
0.0010437352,
0.0043095103,
-0.020730289,
-0.0014540085,
0.03799459,
-0.015885781,
-0.01433659,
-0.0111134825,
-0.018459016,
0.0005518176,
0.0070567005,
-0.028174287,
0.024970872,
-0.009583984,
0.030800035,
0.008415526,
-0.044847794,
0.018406501,
0.033189468,
0.014612293,
-0.023145977,
-0.009085092,
0.006078609,
-0.003346189,
0.007627801,
-0.0076606227,
0.013877084,
-0.01286617,
-0.010752442,
-0.0012168706,
-0.0018380244,
0.0019299255,
-0.00045253144,
0.011152869,
-0.019049808,
0.03098384,
0.0061770747,
-0.00627554,
0.0067022243,
-0.019574959,
-0.013627637,
0.02311972,
-0.0013112334,
0.013640766,
0.00010313245,
-0.005937475,
0.030484946,
0.0042734067,
-0.005711004,
0.02990728,
-0.013017151,
0.021583658,
-0.027675394,
0.024130633,
0.0041355547,
0.01109379,
-0.008382704,
-0.010201035,
0.012465743,
-0.003666202,
-0.010312629,
-0.012898992,
-0.026047431,
0.015675722,
-0.017855093,
-0.019404285,
0.019076066,
0.008533685,
-0.006006401,
0.008389268,
0.01651596,
0.005881678,
-0.024892101,
0.013614508,
0.004427669,
-0.04925905,
0.047867406,
0.02541725,
-0.030222371,
-0.015426275,
0.014310332,
0.0038270291,
0.00936736,
0.0005386888,
0.0119734155,
-0.007312711,
0.032270454,
0.0173562,
0.018327728,
-0.0066365805,
-0.0073914835,
0.05493067,
0.0248002,
0.01339132,
-0.030091085,
0.023474196,
-0.010581768,
-0.011723969,
-0.009288588,
-0.005461558,
-0.0040863217,
-0.021465499,
0.0024895384,
-0.012754576,
-0.016988596,
0.022738986,
-0.0071223443,
-0.024235664,
0.04710594,
-0.022857144,
0.0013555429,
-0.016384674,
0.015373761,
0.033084437,
0.0038204647,
-0.016673507,
-0.0031853619,
0.0027045214,
-0.024012474,
-0.012341021,
-0.013890212,
-0.012649545,
0.014270945,
0.015833266,
0.008776566,
0.0014138017,
-0.011789613,
0.002958891,
-0.035027493,
-0.0048543536,
-0.0061212773,
-0.020441456,
0.0034758353,
0.0026273902,
0.02008698,
-0.025903014,
0.024931487,
0.016909823,
-0.029644707,
-0.028699437,
-0.0014179045,
-0.028226802,
-0.019903177,
-0.017434973,
0.02217445,
-0.026913928,
-0.03465989,
-0.0215574,
0.008815953,
0.009176993,
-0.010680234,
0.035526384,
-0.005126775,
0.010338887,
0.009905638,
-0.018800363,
-0.16416183,
-0.012537952,
0.011533602,
-0.024813328,
0.030091085,
0.009629934,
-0.0015565768,
-0.015006156,
-0.009071963,
0.013614508,
0.04736851,
0.007142037,
-0.05965702,
-0.026428163,
0.01570198,
0.005930911,
-0.010995324,
0.032296713,
0.03064249,
-0.0018971036,
0.038440965,
-0.02636252,
0.01924674,
0.007358662,
0.005405761,
-0.005185854,
0.017645033,
-0.0110215815,
-0.019483058,
-0.022095678,
-0.015780753,
0.0072339387,
0.012104703,
-0.006045787,
-0.001637811,
-0.015583821,
-0.008934111,
-0.013798311,
0.0044867485,
0.034922462,
0.021189794,
-0.0005407402,
0.016752278,
0.0066168876,
-0.0014261099,
0.031561505,
-0.0080676135,
-0.02363174,
0.031876594,
-0.027386563,
0.02206942,
-0.013745796,
0.010181342,
0.032611802,
0.0077393954,
0.015032413,
0.017920736,
0.025706083,
0.009360795,
0.0007331584,
0.006255847,
-0.0011922541,
0.01570198,
-0.025811113,
-0.013745796,
-0.026730126,
-0.0022269634,
0.015268731,
-0.03807336,
-0.0007081317,
-0.00050586695,
-0.0007036187,
0.012603595,
-0.019496186,
0.034029707,
0.005546895,
-0.0037974895,
0.00394847,
0.034344796,
-0.011159433,
-0.03413474,
0.041591864,
-0.0055272016,
0.0029030938,
-0.015833266,
0.0077656526,
-0.0025797985,
0.024143763,
-0.008802824,
-0.009275459,
0.0061442526,
-0.010798393,
0.00046976292,
0.0006310003,
0.01664725,
0.016410932,
-0.0073520974,
-0.029434647,
-0.0040994505,
-0.0065413974,
0.032821864,
0.004493313,
-0.03234923,
0.016712893,
0.055928454,
-0.024458852,
-0.03473866,
0.010010668,
0.055193245,
-0.004979077,
-0.009524904,
0.009787479,
0.011809306,
0.02459014,
0.01673915,
0.032611802,
-0.019929435,
0.014507263,
0.017408716,
-0.039202433,
0.04665956,
0.0024961026,
-0.017841965,
0.023093462,
-0.006242718,
-0.024183149,
-0.13590877,
-0.010135391,
0.0055567413,
0.028830724,
-0.0144547485,
0.038152132,
0.006216461,
0.028305575,
-0.024196276,
0.030484946,
-0.019824404,
-0.029145814,
0.004631165,
-0.014756709,
0.04319357,
0.012892428,
0.010325758,
0.010936244,
-0.028568149,
0.044637732,
0.016069584,
0.008126693,
-0.023461068,
-0.013109052,
0.0030442278,
0.020060722,
-0.043298602,
0.011632068,
0.03368836,
0.02961845,
0.0112119485,
-0.019010423,
0.0021432675,
-0.0070173144,
-0.014861739,
-0.008770002,
-0.016975468,
-0.018997295,
0.028751953,
-0.027675394,
-0.016397802,
0.00957742,
0.004755888,
-0.017513746,
0.011225077,
-0.023172235,
-0.021465499,
-0.0038106183,
0.0032641343,
-0.019732503,
-0.050493155,
-0.022817759,
0.0074046124,
0.0070041856,
0.013653895,
-0.02688767,
0.010719621,
0.0031607454,
-0.008461476,
-0.00157627,
-0.01171084,
-0.023054076,
-0.0049593835,
-0.030353658,
0.012898992,
-0.022594571,
-0.03508001,
-0.029329617,
0.015255602,
-0.0015951425,
-0.012511694,
0.015019285,
-0.028725695,
0.0013153361,
-0.011553296,
-0.0021383443,
-0.006331337,
-0.0017067369,
-0.020992864,
0.0038762619,
-0.0016435548,
-0.028016742,
0.019049808,
-0.009236072,
0.03660294,
0.0021728072,
0.016410932,
-0.014691066,
0.006679249,
-0.0173562,
0.0010027079,
0.038335934,
-0.003646509,
-0.027123988,
0.0152162155,
0.0035710186,
0.00024718966,
-0.0050315917,
0.047132194,
0.023474196,
-0.024655784,
-0.0237499,
-0.04939034,
0.021728072,
0.0019430543,
-0.013483222,
-0.006459343,
-0.0024419466,
0.012144089,
-0.014874868,
-0.008264545,
0.02103225,
-0.0024353822,
-0.010096005,
-0.024340693,
-0.0023451222,
-0.020704031,
-0.0019693119,
0.02292279,
-0.013082795,
0.021806845,
0.024970872,
0.006134406,
-0.009426439,
0.006101584,
-0.0067744325,
-0.023408553,
0.012800527,
-0.014481006,
0.013824568,
0.012537952,
-0.027281532,
0.013877084,
-0.04363995,
0.0008582917,
0.012977765,
-0.002696316,
0.0021022402,
0.01318126,
0.030589975,
0.030616233,
0.037784528,
-0.015124314,
-0.022318866,
0.0016648889,
0.011901207,
-0.008336754,
-0.00846804,
-0.008303931,
0.019903177,
-0.010312629,
-0.011474523,
0.03287438,
0.015242473,
-0.0029096582,
-0.012419793,
0.0053499634,
-0.039465006,
-0.012321327,
0.012721754,
-0.00846804,
-0.014664808,
0.037600726,
0.0050348737,
0.040095188,
0.0036694843,
-0.010174777,
-0.017618775,
-0.01799951,
-0.011907772,
-0.0113038495,
-0.0075818505,
-0.011415444,
0.0013095923,
0.007076394,
0.023894316,
0.014179044,
0.0090194475,
-0.008533685,
0.009616806,
-0.016384674,
0.0014548291,
0.012682368,
0.009780915,
-0.0044604912,
0.00747682,
0.023946831,
0.0057208505,
0.0035152214,
0.021045377,
-0.011704276,
0.009708707,
0.00478871,
0.011192256,
0.011106919,
0.014612293,
0.008323625,
0.020152623,
-0.0033150082,
0.0029818662,
-0.0038335936,
0.027649136,
-0.0017887915,
0.019732503,
0.020585872,
-0.02741282,
-0.018157054,
0.017316815,
-0.02688767,
-0.017395588,
-0.018642819,
-0.00037375896,
0.0014367771,
0.02415689,
0.0065643727,
0.010378273,
-0.027176503,
-0.007358662,
0.019010423,
-0.02145237,
-0.012091574,
0.016214,
0.011756791,
0.027255274,
-0.003011406,
-0.0005977682,
0.007942891,
-0.0024731273,
0.038677283,
-0.02342168,
0.022213837,
-0.017041111,
0.017763192,
-0.014310332,
0.0042143273,
-0.0126364175,
-0.011723969,
-0.027176503,
-0.003383934,
-0.0017149423,
-0.022200707,
0.0788775,
0.016384674,
-0.021938132,
0.02125544,
-0.012577338,
0.035316326,
0.017027982,
0.013279726,
-0.009045705,
-0.019955693,
0.02459014,
-0.030589975,
0.023697386,
-0.017658163,
-0.0045589567,
0.0072273742,
-0.005215394,
-0.014677937,
-0.002258144,
-0.010201035,
0.024051862,
-0.017303687,
0.011822435,
0.018957907,
-0.0045523923,
-0.008579635,
0.033084437,
-0.022660214,
0.009406745,
-0.008546813,
0.036130305,
0.013351934,
-0.04718471,
0.0028981704,
-0.02334291,
0.016266515,
-0.0069844923,
-0.028410604,
0.024984002,
0.014704195,
-0.027255274,
-0.0010609668,
-0.0058357273,
-0.010791829,
-0.019995078,
-0.013371627,
-0.016345287,
-0.0023123003,
-0.009557727
] |
PURPOSE Mutations in the leucine rich, glioma inactivated gene (LGI1) were recently described in a small number of families with autosomal dominant lateral temporal epilepsy (ADLTE). ADLTE is characterized by partial seizures with symptoms suggestive of a lateral temporal onset, including frequent auditory aura. Here we report the results of clinical and genetic analyses of two newly identified families with ADTLE. METHODS We identified two families whose seizure semiology was suggestive of ADLTE. Evaluation included a detailed history and neurologic examination, as well as collection of DNA. The coding sequence of the LGI1 gene from affected subjects from both | [
-0.005915713,
0.023496602,
-0.010923981,
-0.043501966,
-0.03560511,
0.03446907,
-0.020046925,
0.019700572,
-0.026738469,
-0.010937835,
0.013396943,
0.025574721,
0.0070725325,
0.026031908,
0.0046515237,
-0.011339605,
0.024452537,
-0.0093099745,
0.005306131,
0.022693062,
-0.009261485,
-0.004145848,
0.00093255605,
-0.012025384,
0.025089826,
-0.006397144,
0.010792366,
-0.032030746,
-0.030922415,
0.0037717866,
0.011824499,
0.0021266087,
-0.0061131343,
-0.0020313617,
0.0006286311,
0.0030981295,
0.016278602,
0.011007105,
0.030894708,
-0.03275116,
0.008056176,
0.00023313901,
-0.0008472666,
-0.016638808,
-0.025754826,
0.011575124,
-0.0044402485,
-0.010113514,
-0.009836432,
-0.002339616,
-0.008464873,
0.028844297,
-0.019755987,
-0.0017698649,
-0.011450438,
-0.018315159,
0.03164283,
0.007557427,
-0.0020850464,
-0.024438683,
-0.000030955318,
-0.018675366,
-0.027264925,
-0.009095236,
-0.00310852,
0.00096892315,
-0.009046746,
0.0111387195,
0.0034652639,
0.004450639,
0.021654004,
0.008444091,
-0.016597247,
-0.010362889,
0.015655166,
-0.02768055,
-0.016694225,
-0.019672863,
-0.011658249,
0.0053269127,
0.011291115,
-0.0038514477,
0.0050429027,
-0.002753508,
-0.00009508478,
0.007882999,
-0.011422729,
0.00211795,
-0.009877994,
0.0032332074,
-0.0096078385,
-0.0061927955,
0.0101689305,
0.004907825,
-0.015585895,
0.012060019,
0.00083730894,
-0.006684617,
-0.017040579,
-0.024161601,
-0.01731766,
0.012787361,
-0.018439846,
-0.00795227,
-0.012808142,
-0.034108866,
-0.00052818866,
0.0074604484,
0.01892474,
-0.013015954,
-0.011942259,
0.028165445,
0.015849123,
-0.0066395914,
0.012773506,
-0.0090606,
0.030479083,
0.0037302242,
-0.00095593487,
0.00638329,
0.01828745,
0.0025439644,
0.0070621422,
-0.013334599,
0.012752726,
0.016915891,
-0.034164283,
-0.0069513093,
-0.014096576,
-0.008804299,
0.0013559728,
-0.008721174,
0.006047327,
-0.004093895,
-0.010210493,
-0.00411814,
-0.002710214,
-0.015613603,
-0.026586073,
-0.0121847065,
0.016430996,
0.029481586,
-0.0271818,
0.0034687275,
-0.0019794086,
0.037489273,
0.016971307,
0.02402306,
-0.006646518,
0.0029665153,
0.011644395,
-0.023067124,
0.011270334,
-0.0009897043,
0.008437164,
-0.001473733,
0.001695399,
0.01932651,
-0.021667857,
0.0022772725,
-0.023773685,
-0.013251474,
-0.009171433,
0.021847961,
0.026793886,
0.028068464,
0.009891848,
-0.017137557,
0.0026374797,
-0.0041631656,
-0.0067504244,
0.03721219,
-0.028123882,
0.0071556577,
-0.012752726,
0.00534423,
0.00022859313,
0.018800052,
-0.02479889,
-0.021806398,
-0.0046238154,
0.0271818,
0.032030746,
0.010037316,
-0.01939578,
0.0004576192,
0.020919735,
0.00870732,
-0.0009247631,
-0.032252412,
0.016112352,
0.00679545,
-0.009289193,
-0.027791383,
-0.63972825,
0.0055416515,
0.03599303,
-0.0005779769,
0.0025785996,
0.031282622,
0.00071478647,
0.01758089,
-0.018065784,
0.038874686,
-0.016680371,
0.023607435,
0.01932651,
-0.011942259,
-0.022859313,
-0.02848409,
-0.016888183,
-0.0063105556,
0.037406147,
0.007917634,
-0.0047727474,
0.004384832,
0.007917634,
0.0026392115,
0.022637647,
0.027264925,
-0.005448136,
-0.016721934,
-0.01651412,
0.02529764,
-0.029398462,
0.0069409185,
-0.015253396,
0.020268591,
0.05087236,
-0.0051398817,
-0.006573784,
0.02479889,
0.0056836563,
0.019229531,
-0.006036937,
-0.006106207,
0.01852297,
0.011055595,
-0.010016535,
0.03771094,
0.0042601447,
0.010792366,
0.0002619296,
-0.019215677,
0.015613603,
-0.0018079638,
-0.01674964,
-0.008797372,
0.010723095,
0.012281685,
0.030008042,
-0.010556846,
0.010189712,
-0.003013273,
-0.0037544689,
0.02694628,
-0.0045995708,
0.0029370752,
-0.010667679,
0.0030548354,
0.0014953801,
0.0037336878,
-0.008832007,
-0.022762334,
0.010591482,
0.044582587,
0.0011585515,
0.023635143,
0.03117179,
0.033194494,
0.00046108273,
0.03402574,
0.003139692,
0.00927534,
0.008457946,
-0.003643636,
-0.02439712,
-0.012260904,
0.018619949,
-0.00060958165,
-0.02241598,
0.01486548,
-0.019104844,
0.006417925,
0.021820253,
0.009947265,
-0.0060923533,
-0.04610654,
-0.0011646127,
0.012420227,
-0.017968806,
0.026738469,
0.005649021,
-0.008832007,
-0.019035572,
-0.0144221485,
0.0037717866,
-0.00073773233,
0.016015373,
0.014269752,
-0.027431175,
-0.007522792,
0.0271818,
-0.018966302,
-0.024424829,
-0.003494704,
0.015807562,
-0.004731185,
-0.009704817,
-0.030950123,
-0.008194718,
-0.0067712055,
-0.0022080017,
-0.028733464,
-0.00035955795,
0.004384832,
0.00825706,
-0.0057044374,
0.0055208704,
0.003938036,
0.0050325124,
0.007758312,
0.0072110742,
-0.0058291247,
-0.01439444,
-0.034219697,
0.016763495,
-0.009247631,
0.0072387825,
-0.011755228,
0.025990346,
-0.001821818,
0.013819493,
-0.018910887,
-0.021584732,
-0.006826622,
0.0077098226,
0.0061027436,
-0.0066603725,
0.0046826955,
-0.011956113,
-0.0070794597,
-0.0038618385,
0.00021192488,
0.00004613533,
0.009261485,
-0.011824499,
0.02610118,
0.0006043864,
-0.02116911,
-0.029647836,
-0.035688236,
0.0029110988,
-0.0048316275,
0.014782355,
-0.0013689611,
0.0032349392,
-0.0030340543,
-0.024452537,
-0.029703252,
0.007633625,
0.009968046,
-0.01486548,
-0.023995351,
0.005649021,
-0.018259741,
-0.011097157,
0.012510278,
0.018190471,
0.014200482,
0.000013279128,
-0.015876831,
0.00470694,
-0.00993341,
-0.0043328786,
-0.002398496,
-0.0041423845,
-0.002576868,
0.013597827,
0.01788568,
0.015308812,
-0.012898194,
0.0069305277,
0.020850465,
-0.015488916,
0.022956291,
0.0011204527,
0.0074673756,
-0.0043640505,
0.029010545,
0.03463532,
-0.007765239,
-0.017650161,
0.0072387825,
0.023261081,
-0.0365749,
0.02211119,
-0.014242045,
0.03178137,
-0.039207183,
-0.003352699,
-0.028179297,
0.008561851,
0.00042817916,
0.008388675,
-0.00148066,
-0.02220817,
0.011492,
-0.010612262,
0.026738469,
0.0019447734,
0.002124877,
0.0109516885,
-0.01651412,
0.00887357,
0.0022530276,
0.005420428,
0.004464493,
-0.010612262,
0.029398462,
-0.0034531415,
0.0077028954,
-0.010639971,
-0.005926104,
-0.0019482368,
0.027167946,
0.019977653,
0.023732122,
-0.015294958,
0.002050411,
0.0021802934,
-0.007758312,
0.027638987,
-0.012690382,
0.005035976,
0.00035631086,
0.0042116554,
-0.010549919,
0.010882419,
0.00021582135,
0.026835447,
0.0019430416,
-0.015045584,
0.010189712,
-0.011034814,
0.008173936,
-0.009559349,
-0.0121085085,
0.011699812,
-0.018148908,
0.0132653285,
0.02774982,
0.022457542,
0.016597247,
0.011561271,
-0.010979397,
-0.025408473,
-0.007966124,
-0.013182203,
-0.004758893,
0.0006779864,
0.017303808,
0.018883178,
0.000146226,
-0.02895513,
0.0019014792,
0.0009732525,
-0.061456915,
0.012863559,
0.0065114405,
-0.002777753,
0.020185465,
0.016971307,
0.027431175,
-0.009843359,
-0.04691008,
0.039678223,
0.02623972,
-0.020767339,
-0.034275115,
-0.008160082,
-0.020019216,
0.0012122362,
0.009400026,
0.019104844,
0.008478727,
0.014713084,
0.0140134515,
0.002777753,
-0.009185287,
0.016112352,
-0.012579549,
-0.000043023563,
-0.02378754,
0.0013100811,
0.017857973,
-0.02975867,
0.011360385,
0.029980335,
0.022914728,
-0.022596084,
0.004966705,
0.013182203,
-0.01224705,
0.022914728,
-0.021307651,
0.014532981,
-0.013099079,
0.010293618,
-0.022942437,
0.00371637,
0.011048668,
0.010307472,
0.0138264205,
-0.014810064,
-0.04546925,
-0.009358464,
0.009968046,
0.021182964,
0.038846977,
-0.00007895771,
0.019409634,
0.022609938,
0.01771943,
-0.016347872,
-0.0024244725,
0.015225688,
0.004984023,
-0.036491774,
0.003709443,
-0.020088486,
0.031227207,
0.015558187,
0.036519483,
0.008665757,
-0.02187567,
-0.007114095,
0.0031518142,
0.0010693655,
0.021279942,
0.021626296,
0.007765239,
-0.005448136,
-0.026530657,
0.00667769,
0.016680371,
-0.0020244345,
0.015405791,
-0.0122955395,
-0.014616106,
-0.00020770369,
0.028040757,
0.013812566,
-0.0032955508,
0.009635546,
-0.001347314,
0.00293188,
0.0033856027,
0.021113692,
0.0015126977,
0.015876831,
0.0074812295,
0.016846621,
-0.021224525,
-0.022831604,
0.012628038,
-0.0045199096,
-0.009053674,
0.018204326,
-0.017567035,
-0.0017482179,
-0.010120441,
0.038542185,
0.0024192773,
-0.005953812,
-0.008922059,
0.007917634,
-0.012156998,
-0.010155076,
-0.028400963,
-0.005929567,
0.0032193533,
-0.008700393,
-0.00858956,
-0.00006629417,
-0.011367313,
-0.041867178,
0.0032072307,
-0.008547997,
-0.009760234,
-0.048932783,
-0.0028972446,
0.010584555,
0.009573203,
0.012918975,
-0.020989005,
0.011111012,
0.019977653,
-0.02019932,
-0.0011879916,
-0.009732526,
-0.021460045,
0.013847202,
0.025616284,
0.006805841,
-0.009843359,
-0.0056801927,
0.022083482,
0.00929612,
-0.015544333,
0.022028064,
0.010965543,
-0.016694225,
0.012357883,
0.0020348253,
0.01184528,
-0.018162763,
-0.008042322,
0.013279183,
-0.031033248,
-0.026364407,
-0.017760994,
-0.014532981,
-0.012399445,
0.010252056,
-0.00044246623,
0.009704817,
-0.008838934,
-0.014117357,
0.015128708,
0.0023292254,
0.0028626095,
0.0144221485,
0.024466392,
-0.001939578,
0.0053338395,
0.0069270646,
-0.0050082677,
-0.0034358238,
-0.010390596,
0.016624955,
-0.002154317,
-0.017373078,
0.016805058,
0.005035976,
-0.0084163835,
-0.012628038,
-0.010965543,
0.00458918,
0.03942885,
0.012066946,
-0.005725219,
-0.017109849,
0.00620665,
-0.015724435,
-0.0011602833,
-0.00086371833,
-0.005115637,
0.0000734377,
0.009441589,
-0.0138264205,
-0.0028193153,
-0.00568712,
-0.030395959,
-0.021030568,
-0.009850286,
-0.01323762,
0.01701287,
-0.019769842,
0.00079834415,
-0.014879335,
-0.019284947,
0.0052022254,
-0.029841794,
0.010813148,
-0.0014105235,
0.025879513,
-0.00046454626,
0.03352699,
0.0000072788293,
0.02067036,
0.01828745,
0.009289193,
0.02258223,
-0.009538568,
-0.000093515366,
-0.015876831,
-0.014588398,
-0.0044298577,
0.0041493117,
0.039318018,
-0.0028712682,
0.0066222735,
0.023884518,
-0.010293618,
-0.01758089,
0.017968806,
-0.05757776,
-0.030008042,
0.04120218,
-0.0033700168,
0.003983062,
-0.036851984,
0.0009013843,
0.055056307,
-0.0017014602,
0.00096286193,
0.002606308,
0.02845638,
-0.021418484,
0.033305325,
-0.012226269,
0.01614006,
-0.009157579,
-0.02328879,
0.0021612442,
-0.018093493,
0.0051329546,
0.0047935285,
0.011221845,
-0.00003141532,
-0.0013299964,
0.0020625335,
0.008083885,
-0.03801573,
-0.0033076731,
-0.030312834,
-0.010078879,
-0.026793886,
-0.010286691,
-0.009794869,
-0.027777528,
0.029232211,
0.011769082,
-0.0013577046,
0.017234536,
-0.0066499817,
-0.02274848,
0.019118698,
0.0039137914,
0.044582587,
0.0005424757,
0.02975867,
-0.00011537892,
0.0015360765,
-0.011838353,
0.012399445,
0.010037316,
0.0058810776,
0.011450438,
0.00858956,
-0.013632462,
0.012371737,
0.024812745,
0.007405032,
-0.036186986,
-0.015488916,
0.013583973,
-0.0013854129,
0.016250893,
-0.012226269,
-0.023427332,
-0.005025585,
0.019991508,
-0.020296298,
0.02274848,
-0.009524713,
-0.00778602,
0.0027413857,
0.023870664,
-0.013341526,
-0.00025651784,
-0.008908205,
0.012662673,
0.017691722,
-0.0121085085,
-0.030479083,
0.0027067505,
-0.0035102898,
0.030894708,
-0.021044422,
-0.009490078,
-0.0036263182,
0.0036367087,
0.017137557,
-0.013438505,
0.0019811403,
0.03829281,
-0.026364407,
0.00019980251,
-0.0026409433,
-0.013036735,
-0.009316902,
0.008125447,
-0.010847783,
-0.006805841,
-0.010882419,
0.0020608017,
0.018897032,
-0.0069478457,
-0.00673657,
0.006944382,
-0.03815427,
0.0006026546,
-0.01236481,
-0.018980157,
0.03452449,
-0.040925097,
0.015765999,
0.00019590605,
-0.0024244725,
0.010265909,
0.042504467,
-0.00771675,
-0.020046925,
0.034884695,
-0.029287629,
-0.0061477697,
0.0010347302,
-0.008035394,
-0.015184125,
0.014976313,
0.010162003,
-0.03277887,
0.023676706,
-0.021030568,
-0.012136217,
-0.012378664,
-0.006386753,
-0.0053130584,
-0.0073634693,
-0.019520467,
0.0024833526,
-0.012136217,
0.029398462,
0.023967642,
-0.022526814,
0.007308053,
-0.016666517,
0.009649401,
0.01276658,
0.0030686895,
-0.0040384787,
0.030673042,
0.010584555,
-0.0008173936,
-0.017954951,
0.007515865,
-0.019298801,
0.004945924,
-0.003132765,
0.036519483,
0.022554522,
-0.017400786,
-0.011526635,
0.007564354,
-0.0073981048,
-0.0040765773,
-0.0016131401,
-0.014283607,
-0.007425813,
0.033970322,
-0.022346709,
0.0021127546,
-0.0022339784,
-0.0075920625,
-0.0476582,
-0.0017941097,
-0.025311492,
0.03385949,
-0.0016607636,
-0.012489497,
-0.009358464,
-0.009088309,
-0.029176796,
0.01654183,
-0.0036193912,
0.007765239,
0.013112932,
0.040897388,
0.008513362,
0.008250134,
0.00006748476,
0.010148149,
-0.0029665153,
0.0019586275,
0.0048697265,
-0.02083661,
0.016680371,
0.0091229435,
-0.027264925,
-0.015101001,
-0.003013273,
0.021903377,
-0.014616106,
0.021266088,
-0.023801394,
0.0072595635,
-0.0033249909,
0.010058098,
-0.018716928,
0.039955307,
-0.0014200482,
-0.015987664,
0.019340364,
-0.015391937,
0.0037440783,
-0.013272256,
0.0067504244,
0.017802555,
0.0094970055,
0.010411378,
-0.014339023,
0.013784858,
0.0032920875,
-0.009600911,
0.042227384,
0.019340364,
0.0023967642,
0.008132374,
0.011152574,
-0.0027638988,
-0.024313996,
-0.021903377,
-0.009621693,
-0.019451197,
0.0021595124,
-0.020060778,
0.0026825056,
0.0057944893,
-0.004866263,
-0.03114408,
-0.0022512958,
-0.015405791,
0.003198572,
-0.03338845,
0.024078475,
0.0061789416,
-0.04339113,
-0.024410974,
0.00026366138,
-0.022623792,
-0.009995754,
-0.019492758,
0.036353234,
-0.04704862,
0.021127546,
0.007335761,
-0.0122193415,
0.00034830146,
-0.015128708,
-0.026267428,
-0.030562209,
-0.014560689,
0.19506614,
0.0049112886,
-0.0029076352,
0.0124825705,
-0.027846798,
0.0018477944,
0.028013049,
0.012607257,
-0.029149087,
0.011041741,
0.01651412,
-0.007820656,
-0.014657668,
0.0032089625,
0.00778602,
-0.01701287,
-0.04034322,
-0.020850465,
-0.025685554,
0.0020625335,
0.017968806,
0.003212426,
-0.0072526364,
-0.020448694,
0.027763674,
0.0028608777,
-0.005115637,
-0.0017170461,
0.024341704,
0.015544333,
-0.025976492,
-0.0010104856,
0.006165087,
-0.0018529898,
-0.011803717,
-0.0008446689,
-0.011104085,
-0.0065391487,
0.012808142,
0.027722111,
0.007882999,
0.00040826385,
-0.012669601,
-0.023399623,
-0.021598587,
0.018232033,
0.004596107,
-0.008797372,
-0.009503933,
-0.008797372,
-0.03438595,
-0.001096208,
-0.010633044,
0.025353055,
-0.0009386172,
-0.014920897,
0.02829013,
0.028026903,
-0.0057182917,
0.023884518,
-0.0084163835,
0.005025585,
-0.035799067,
0.03275116,
0.009753306,
0.026932426,
0.0030738849,
-0.0062135765,
0.017941097,
-0.017733285,
0.021806398,
-0.03463532,
-0.017456202,
-0.0028608777,
-0.007065606,
-0.016458705,
0.020490257,
0.005586677,
-0.005455063,
0.01748391,
-0.0010858173,
-0.00079791126,
-0.017664013,
0.02121067,
-0.019742133,
-0.021307651,
0.016929746,
0.0150178755,
-0.029204503,
-0.008499508,
-0.008520289,
-0.0011308433,
0.004093895,
0.022970146,
-0.0032591838,
-0.019381925,
0.0049909498,
-0.017206827,
0.0025197198,
-0.037794065,
-0.018606095,
0.059184838,
0.011602833,
0.00811852,
-0.016430996,
0.018675366,
-0.010806221,
0.010923981,
0.012544913,
-0.011048668,
0.016181622,
-0.03771094,
0.005136418,
-0.013396943,
-0.01989453,
0.004156239,
-0.0015404059,
-0.021764837,
0.023815248,
-0.0007567818,
-0.008748882,
-0.025020557,
-0.000054225926,
0.02664149,
-0.0068300855,
-0.020642651,
-0.035688236,
-0.014546835,
-0.005694047,
-0.016971307,
-0.012143143,
-0.010030389,
0.021252234,
0.005174517,
-0.0041319937,
-0.011928405,
-0.00032860262,
0.0022183924,
-0.0090606,
0.011311896,
0.001428707,
-0.004277462,
0.01219856,
-0.0039657443,
0.0045614718,
-0.030229708,
-0.003228012,
0.016181622,
-0.04117447,
-0.009469297,
-0.011866061,
-0.017068287,
-0.0025127926,
0.00007040711,
0.01620933,
-0.01316835,
-0.017345369,
-0.016763495,
0.003872229,
0.017567035,
-0.024965141,
0.01956203,
0.011976894,
-0.010667679,
0.0039934525,
-0.0074881567,
-0.17844118,
0.0071418034,
0.0025405008,
-0.017359223,
0.0028660728,
0.022693062,
0.04488738,
-0.0070829233,
-0.0042462903,
0.009656328,
0.03718448,
-0.02224973,
-0.03435824,
-0.004866263,
-0.0129674645,
0.006012692,
-0.027500445,
0.035688236,
0.014082722,
0.0137502225,
0.026586073,
-0.039927598,
0.012510278,
0.00015001424,
0.01758089,
0.008811226,
0.0012728481,
-0.008935913,
-0.013286109,
-0.012039238,
-0.006345191,
0.010577627,
0.05245173,
0.00083168066,
0.008298623,
-0.0028314376,
-0.010861637,
0.0056005316,
-0.015197979,
0.0028037294,
0.016929746,
0.02798534,
0.019409634,
0.012690382,
-0.002168171,
0.027611278,
0.010501429,
-0.018883178,
-0.017664013,
0.0008247536,
0.012517205,
-0.022790043,
0.0077929473,
0.020157758,
0.0305345,
-0.0013074834,
0.007418886,
0.002658261,
0.0020486794,
-0.012912048,
-0.012212414,
-0.033222202,
0.031587414,
0.007529719,
0.016084643,
-0.029980335,
-0.03294512,
-0.007425813,
-0.006985944,
0.022499105,
-0.028567214,
-0.015253396,
0.015516624,
-0.014532981,
0.032363243,
0.011568198,
-0.018869324,
0.028317839,
0.013535484,
-0.027888361,
-0.018952448,
0.0033267227,
-0.04034322,
0.013521629,
-0.021972649,
0.005846442,
-0.0024452538,
0.016888183,
-0.0002517555,
-0.034108866,
0.01758089,
-0.004817773,
-0.0031102519,
-0.027652841,
0.015336521,
0.04691008,
-0.018730782,
0.006546076,
-0.0112149175,
0.014726939,
0.0016997284,
-0.020060778,
-0.018606095,
0.016126206,
0.028096173,
-0.004277462,
-0.026018053,
0.025643993,
0.032557204,
-0.0143113155,
-0.019880675,
-0.009649401,
-0.021820253,
0.020060778,
-0.0032661108,
0.007744458,
-0.01758089,
-0.0019828721,
0.0124133,
-0.0027968022,
0.055721305,
-0.017289953,
0.018010367,
-0.019146405,
-0.005448136,
-0.0060715717,
-0.096646406,
-0.017289953,
0.002479889,
0.0067850593,
-0.02090588,
0.0041112127,
-0.002154317,
0.027292633,
-0.011838353,
0.046826955,
-0.03751698,
-0.0150178755,
-0.0040384787,
-0.010286691,
0.00823628,
-0.016985161,
0.012918975,
0.009753306,
-0.039068643,
0.023953788,
-0.019839112,
-0.0034219697,
0.01885547,
-0.03577136,
-0.0102035655,
-0.020282445,
-0.03452449,
0.028678047,
-0.0035812922,
0.009046746,
0.013840275,
-0.009358464,
0.020947443,
0.019936092,
-0.011949186,
-0.027431175,
0.017470056,
-0.014269752,
0.03879156,
0.0030167366,
-0.0032384025,
0.017941097,
0.014768502,
0.016458705,
0.017192975,
-0.013251474,
-0.00887357,
0.013348453,
0.025976492,
-0.024203163,
-0.01137424,
-0.015253396,
-0.03324991,
0.004516446,
0.014505273,
-0.005486235,
0.021750983,
0.01979755,
-0.026973989,
-0.00929612,
-0.0019967263,
0.0018841615,
-0.013895691,
-0.0069928714,
0.003906864,
-0.016098497,
-0.013057516,
-0.039179478,
-0.00051216985,
0.004984023,
0.00065547344,
0.007564354,
-0.0073011257,
-0.0069409185,
-0.047270287,
0.00632441,
-0.004197801,
-0.006019619,
0.016126206,
-0.0044125402,
-0.020919735,
-0.011983821,
-0.00050827337,
-0.025990346,
0.019340364,
-0.0020330935,
-0.0017109849,
-0.0070240432,
0.0041319937,
-0.031670537,
-0.0057425364,
0.03302824,
-0.0045857164,
-0.019659009,
-0.021764837,
0.006525295,
-0.00899133,
-0.014685377,
0.02687701,
0.047602788,
-0.027154092,
-0.037239898,
-0.06483732,
0.027542008,
-0.0050983196,
-0.016527975,
0.0048731896,
0.003782177,
0.017954951,
0.0049493876,
0.0030756167,
0.0044333213,
-0.0017906461,
0.008644977,
0.0067781326,
-0.004928606,
-0.019548176,
-0.043668214,
0.01788568,
0.010432159,
0.025740972,
0.033610117,
0.0214739,
0.02281775,
0.003517217,
0.045136753,
0.0027050187,
-0.0132653285,
-0.018980157,
0.018938594,
-0.007869145,
-0.0122193415,
-0.0018928203,
-0.019423489,
-0.012981319,
0.0033353814,
0.0008758407,
-0.03466303,
0.016098497,
0.018564533,
0.031254914,
0.03848677,
0.002628821,
-0.02241598,
0.019229531,
0.021847961,
0.00621704,
-0.00365749,
-0.028567214,
0.020337861,
0.025408473,
-0.0010979397,
0.027957631,
0.0054689175,
0.001221761,
-0.0090606,
-0.026128886,
0.009406953,
0.00638329,
-0.0026409433,
0.0043328786,
0.010058098,
0.022471396,
-0.008970548,
0.03197533,
0.002124877,
-0.00032297437,
-0.018329013,
-0.029315336,
0.009157579,
-0.006556466,
-0.019811405,
-0.02687701,
-0.010120441,
0.0041112127,
0.021113692,
0.030340541,
-0.014325169,
0.007075996,
-0.013583973,
-0.008582633,
0.0027552398,
0.0018304768,
-0.0139372535,
-0.0013828152,
0.009358464,
0.007522792,
-0.006144306,
-0.0037994948,
0.012344029,
-0.006899356,
-0.006116598,
0.0073703965,
0.01550277,
0.004419467,
0.018772345,
0.003309405,
0.0014841235,
0.00024785902,
-0.028733464,
0.004377905,
0.02369056,
0.014158919,
0.006026546,
-0.0000129882455,
-0.018245887,
-0.015918395,
0.030589916,
-0.04704862,
-0.028303985,
-0.0077929473,
0.0035743653,
0.021806398,
0.024175454,
-0.013694806,
0.0029007082,
-0.010328253,
-0.0059503485,
0.001880698,
0.009552422,
-0.0076890416,
0.02909367,
0.021321503,
0.019603591,
0.027015552,
0.004918216,
0.016874328,
-0.00464806,
0.029509295,
-0.022623792,
0.032169286,
-0.0032089625,
0.011104085,
0.010515284,
-0.051426526,
-0.013112932,
0.004700013,
0.008596487,
0.008146227,
0.033582408,
-0.030783875,
0.0983089,
0.015101001,
-0.014186628,
-0.002628821,
-0.01616777,
0.022526814,
-0.01316835,
0.038708437,
0.0008641513,
-0.043335713,
0.0059849834,
-0.03754469,
0.009503933,
-0.040786557,
-0.044194672,
-0.0014018647,
-0.0055693598,
0.018619949,
0.013764077,
-0.03784948,
0.023441186,
-0.0061512333,
-0.0013706929,
-0.014574544,
-0.0071625845,
0.0008836337,
0.034136575,
-0.006906283,
-0.0038618385,
-0.027805237,
0.01906328,
0.00028119553,
-0.03801573,
-0.018384429,
0.011304969,
-0.025782533,
0.019451197,
-0.047796745,
0.026599927,
-0.002873,
0.0023517383,
0.00435366,
-0.0012156998,
-0.014934751,
0.0096840365,
-0.009476224,
-0.014145065,
-0.002398496,
-0.026364407
] |
Cellular senescence is a fundamental mechanism by which cells remain metabolically active yet cease dividing and undergo distinct phenotypic alterations, including upregulation of p16Ink4a , profound secretome changes, telomere shortening, and decondensation of pericentromeric satellite DNA. Because senescent cells accumulate in multiple tissues with aging, these cells and the dysfunctional factors they secrete, termed the senescence-associated secretory phenotype (SASP), are increasingly recognized as promising therapeutic targets to prevent age-related degenerative pathologies, including osteoporosis. However, the cell type(s) within the | [
-0.0015670498,
-0.0002890555,
0.0068094097,
-0.019221166,
-0.01733185,
0.013054648,
-0.0072358176,
0.007045574,
-0.02625362,
-0.010889807,
0.024443025,
0.02685715,
-0.0104962,
0.004487125,
-0.0064879633,
0.0017105525,
0.0356346,
0.0104962,
0.017659856,
-0.004247681,
-0.04148623,
0.0057925903,
-0.00789183,
-0.022383146,
-0.0059565934,
0.018105945,
0.009236656,
-0.05263844,
-0.008442881,
-0.009604023,
0.0013013647,
-0.0102928355,
-0.0053825825,
-0.0005293201,
0.0043001617,
0.010443719,
0.0049824147,
-0.033981446,
0.0072226976,
-0.02467919,
-0.004145999,
0.0032849824,
-0.012247753,
-0.009223536,
0.009216975,
0.008023033,
-0.0006998833,
-0.012037829,
-0.0102665955,
0.021189203,
0.015403173,
0.0079049505,
-0.026975233,
0.0003038158,
-0.011801665,
-0.0049135336,
-0.013179291,
0.037130307,
0.013369534,
-0.004920094,
0.0005354702,
-0.010384678,
-0.022934197,
0.009905788,
-0.0072686183,
0.010922608,
-0.001682672,
0.008915209,
-0.0010807805,
0.0074391817,
0.042903215,
0.026975233,
-0.0024420065,
0.008738087,
0.0011734423,
-0.02320972,
-0.011696703,
-0.0043526427,
-0.011972228,
0.01318585,
0.02314412,
-0.01685952,
0.009315377,
0.020598792,
0.018643875,
-0.0097024245,
-0.019103084,
0.011316216,
0.01994278,
0.025085917,
0.0017417131,
0.021097362,
0.01786978,
0.030255295,
-0.03841609,
0.0007261238,
0.022343785,
0.0356346,
-0.012280554,
-0.010207554,
-0.029048232,
0.01423547,
-0.013933705,
-0.018014103,
-0.039833076,
0.007098055,
0.01419611,
0.00096597837,
0.014576597,
-0.0036671096,
-0.017686097,
0.03560836,
0.004516646,
-0.047442824,
0.028156055,
-0.0026109298,
0.02154345,
0.011447418,
-0.013448256,
-0.008121435,
0.021267924,
0.008311678,
0.04098766,
-0.014839002,
0.022711152,
-0.013448256,
0.020165823,
-0.0075375834,
-0.0152588505,
-0.008993931,
-0.0027798528,
-0.004247681,
-0.006556845,
0.013369534,
-0.020677513,
-0.013841864,
-0.018565154,
-0.015140768,
-0.016741438,
-0.043375544,
0.012956247,
0.037209027,
-0.026542265,
-0.013192411,
0.017187526,
-0.005713869,
0.011270294,
0.009538421,
0.00016195308,
0.008200156,
-0.0035162268,
-0.0009528581,
0.0068750107,
-0.017620495,
0.0123855155,
0.0114736585,
0.013854983,
0.01633471,
-0.027605005,
-0.016387193,
-0.012011589,
0.0049758544,
0.02096616,
0.002738852,
-0.0010381398,
0.014773401,
-0.011289975,
0.005989394,
0.008141115,
-0.0013046449,
-0.0061337166,
0.006665087,
-0.01313993,
0.017016964,
-0.019103084,
0.016085425,
-0.0132186515,
-0.002155001,
-0.030622663,
-0.049174696,
-0.019903418,
0.011716383,
0.019850938,
0.005933633,
-0.018696355,
0.010305956,
0.02050695,
-0.00020305636,
-0.0009397379,
-0.00792463,
-0.023563968,
0.0114998985,
-0.003207901,
-0.009781146,
-0.6343903,
-0.033902723,
-0.0018630754,
-0.018040342,
0.009177615,
0.024456145,
0.008305118,
-0.007799988,
-0.04628824,
0.008823368,
-0.014366673,
0.017187526,
-0.00089709705,
-0.011394937,
-0.014760281,
-0.03203965,
-0.03143612,
-0.007039014,
0.018853799,
-0.0039787157,
-0.029914169,
0.0111522125,
-0.004779051,
0.03209213,
-0.0006367421,
0.016636476,
0.029782966,
-0.011906627,
0.001992638,
0.038468573,
-0.024889113,
0.018827558,
-0.0029799368,
-0.002894655,
0.046524405,
0.011945987,
-0.003998396,
0.02050695,
0.0023567248,
0.031960927,
-0.0017777939,
0.0072817383,
0.009059533,
-0.000840516,
-0.033351675,
-0.004831532,
-0.005202179,
-0.029153194,
0.0037622317,
0.007045574,
0.016137907,
-0.004795451,
-0.002263243,
0.01629535,
0.0126544805,
0.01365818,
0.02213386,
-0.010955408,
0.00785903,
0.0062977197,
0.0069143716,
0.03739271,
-0.013894345,
0.001629371,
-0.008187036,
0.03521475,
-0.006451883,
-0.0005580206,
0.0031685403,
-0.0045297663,
0.029179435,
0.029494321,
-0.014970205,
-0.0038147126,
0.022737393,
0.014655319,
0.0030570182,
0.017148167,
0.003942635,
0.014025547,
0.017240008,
-0.009879548,
-0.041774876,
0.0013915665,
0.0051988987,
0.0039688754,
-0.02731636,
0.023813253,
-0.004956174,
0.0043329624,
0.020244544,
-0.010148513,
0.0011250614,
-0.060090743,
-0.014996445,
0.005638427,
0.0031652602,
0.0023731252,
-0.007695026,
-0.033299193,
-0.019785337,
0.0030258575,
0.020467589,
0.013907464,
0.034480017,
0.018814437,
-0.03203965,
-0.012136231,
0.053032048,
-0.017463053,
0.03988556,
-0.01945733,
-0.0024288862,
-0.012444557,
-0.031882208,
-0.020533191,
0.04946334,
0.007970552,
-0.0032407017,
-0.019260526,
-0.004683929,
-0.0070718145,
-0.011906627,
-0.009604023,
0.01368442,
0.02365581,
0.014760281,
-0.0013005447,
-0.0046970495,
-0.006934052,
0.0044477647,
-0.009761466,
0.01994278,
-0.010325637,
0.018643875,
0.0022304424,
-0.0025945294,
-0.004893853,
0.02252747,
-0.028575903,
-0.008147675,
-0.01579678,
-0.012149351,
-0.003981996,
-0.0168464,
0.000026176436,
-0.023563968,
-0.009748345,
0.0111522125,
0.00736046,
-0.014484756,
0.0007072635,
0.010135393,
0.006419082,
0.010568361,
-0.0040738373,
-0.0015875502,
-0.027106436,
-0.016347831,
-0.01626911,
-0.010797965,
0.011014449,
-0.027106436,
0.004155839,
-0.019798456,
-0.008456001,
-0.008606884,
0.011198133,
-0.00030299576,
-0.024823513,
0.0043920036,
-0.007918071,
-0.003055378,
0.01103413,
-0.009682744,
0.008344479,
-0.007478542,
0.006540444,
0.0025633688,
-0.011696703,
0.008652804,
-0.018696355,
-0.011388376,
0.011322775,
0.036001965,
0.018538913,
0.038153686,
0.015862381,
0.010640522,
0.012516718,
-0.00044321842,
0.0135925785,
-0.014537237,
0.016124787,
0.0153113315,
-0.026922751,
-0.0027175318,
-0.011316216,
0.013946826,
0.031934686,
0.0036999104,
-0.04256209,
0.004362483,
-0.01738433,
0.012831604,
-0.011749184,
0.0004362483,
-0.011670462,
0.024469266,
0.01888004,
0.0071439757,
0.027106436,
-0.028182296,
0.00093235774,
-0.004995535,
0.009216975,
0.0072292574,
-0.00028475042,
-0.016465914,
-0.0059369127,
-0.012005028,
-0.01630847,
0.011388376,
-0.028287258,
-0.005474424,
0.02474479,
0.010765165,
0.017751697,
-0.012995607,
-0.01577054,
-0.015481895,
0.0074916626,
0.017253129,
0.0040279166,
0.010883247,
0.012319914,
-0.00047642906,
-0.009092333,
0.044451404,
-0.005579386,
-0.0021730412,
0.0022288023,
0.01945733,
-0.009413779,
-0.0066060456,
-0.00367695,
0.04534358,
0.013723781,
-0.008219836,
-0.007006213,
-0.023511488,
0.0074326214,
-0.03169852,
0.006399402,
-0.011972228,
-0.004001676,
0.010384678,
-0.0026355302,
0.04151247,
0.013290813,
0.024101898,
-0.010824206,
0.002676531,
-0.011185013,
-0.0084232,
0.015547495,
0.045999594,
0.005887712,
-0.004943054,
0.012792244,
0.00072284375,
0.0049824147,
-0.0006412522,
-0.029861689,
0.019037481,
0.009715545,
0.007799988,
0.012136231,
0.011972228,
0.013868104,
0.0061337166,
-0.024561107,
0.013382655,
0.013920585,
-0.0063141203,
0.010771725,
-0.029914169,
-0.009426899,
0.005940193,
0.0064420425,
-0.0008257557,
0.024639828,
-0.015062046,
0.004592087,
-0.02578129,
-0.013854983,
0.0020680793,
-0.008554403,
0.03579204,
0.023773892,
0.00015160038,
0.0073998207,
-0.0006892231,
-0.003417825,
0.030176574,
0.012779123,
-0.0067110076,
0.007248938,
-0.023104759,
-0.046813052,
-0.011755744,
-0.020126462,
-0.0066585266,
0.0042116,
0.0027175318,
0.0058450713,
0.011434297,
-0.025597608,
0.03308927,
0.0042804815,
-0.0025568085,
-0.023367165,
-0.010542121,
-0.02206826,
0.03146236,
0.02731636,
0.00012412986,
0.00035978184,
-0.029389359,
0.01786978,
0.005622027,
-0.016885761,
0.027001474,
-0.032302056,
-0.0073539,
-0.015219489,
0.013048088,
-0.00032472616,
0.004411684,
0.008200156,
0.011119411,
-0.023996936,
-0.020795595,
-0.006094356,
0.005510505,
-0.0020631591,
0.017554894,
0.047442824,
0.033456635,
-0.013776262,
-0.009374418,
0.014117388,
-0.005225139,
-0.0016146107,
-0.024941595,
0.026948992,
-0.0017285929,
0.017463053,
-0.0032571019,
-0.024023177,
0.00789183,
0.008528162,
0.008541282,
-0.0050742566,
0.0034998266,
-0.0021763213,
0.03049146,
0.010325637,
-0.0057630697,
0.0013317054,
0.0088692885,
0.012811923,
-0.008698725,
0.00036121687,
0.025400802,
-0.023931336,
-0.0084691215,
-0.021687772,
0.01785666,
0.007006213,
0.00682909,
0.0021582812,
-0.007301419,
-0.007314539,
-0.011316216,
-0.0075966245,
0.025466405,
-0.010200994,
0.00067569286,
0.01416987,
0.0051792185,
-0.024285583,
-0.009505621,
0.0034801462,
0.016439673,
-0.018683236,
-0.018998122,
0.005208739,
-0.012720082,
0.011093171,
0.011335895,
-0.01570494,
-0.02421998,
0.012923446,
0.008193596,
-0.013566338,
-0.0033177831,
-0.05583978,
0.010765165,
0.0036703898,
0.0120640695,
-0.02204202,
-0.024246221,
-0.0015900102,
0.02944184,
-0.018460192,
0.018000983,
0.014510996,
-0.027290119,
0.0046084877,
0.038704738,
0.011283414,
-0.01155894,
0.010850446,
-0.0054449034,
-0.032328296,
-0.014996445,
-0.037077826,
-0.0037097505,
-0.014812762,
-0.019995261,
0.015350692,
-0.016413432,
-0.024285583,
0.012155911,
-0.008685606,
-0.007189897,
-0.020297026,
-0.009879548,
0.013061209,
0.0072226976,
0.014471635,
0.020638153,
0.005192339,
-0.017777938,
-0.011080051,
0.023498368,
0.0004042677,
-0.0059762737,
0.0073539,
-0.005530185,
-0.015075167,
-0.040279165,
-0.014524116,
-0.015495014,
0.040751494,
-0.017226888,
-0.047127936,
-0.020690633,
0.00630756,
0.014589718,
0.008016473,
0.002884815,
-0.009072653,
-0.0141829895,
0.012405196,
-0.014983325,
0.00016441313,
0.039203305,
-0.034138888,
-0.013802502,
-0.0036080687,
0.03046522,
0.0079574315,
-0.0033013828,
0.0037786318,
0.022999797,
0.0067011677,
-0.00684221,
-0.024246221,
0.0057368292,
-0.0064453227,
0.032905586,
0.017449932,
0.012418316,
0.004470725,
0.013566338,
0.023393406,
-0.002993057,
-0.0028733346,
-0.017213767,
0.023721412,
-0.022317544,
0.03327295,
0.004897133,
0.006724128,
0.019286767,
-0.035083547,
0.020231424,
0.011099732,
0.007603185,
-0.04468757,
-0.011506459,
-0.045501027,
-0.047022976,
0.01048308,
-0.011965668,
0.014484756,
-0.03214461,
-0.001730233,
0.01314649,
0.030202815,
-0.013645059,
0.0023960855,
0.030176574,
-0.009912348,
0.03054394,
-0.018092824,
-0.00035363174,
-0.019667255,
-0.018066583,
0.012431436,
-0.0037589516,
0.003729431,
-0.014314192,
0.01843395,
0.011775424,
-0.021674652,
0.008337919,
0.0018778357,
-0.0022025618,
-0.032433257,
-0.01945733,
-0.026975233,
-0.026896512,
-0.012936566,
-0.018237147,
-0.035582118,
-0.005415383,
0.008993931,
-0.03358784,
0.027447563,
-0.003945915,
-0.01888004,
0.036894143,
0.0066093258,
0.018604513,
-0.0126807215,
0.023563968,
0.020362627,
-0.007675346,
-0.010581481,
-0.0000011499437,
-0.009912348,
0.008475681,
0.044005316,
0.008738087,
-0.007937751,
-0.00843632,
0.002460047,
-0.0061665173,
-0.010791405,
-0.037209027,
0.0017499133,
0.00786559,
0.0010988209,
-0.010561801,
0.009394099,
-0.029573042,
-0.011808225,
-0.017279368,
0.0020910397,
0.008751206,
-0.015888622,
-0.017436812,
0.01789602,
-0.006110756,
0.007996792,
0.0044018435,
-0.027001474,
-0.01786978,
-0.01680704,
0.021477848,
-0.018315868,
-0.0076425453,
0.017909141,
-0.0273426,
-0.0074457414,
0.013336734,
0.012870965,
0.011303095,
0.007137416,
-0.015127648,
0.043401785,
-0.019654134,
-0.0130284075,
0.009105453,
0.008167355,
-0.0061861975,
0.008724966,
0.004418244,
-0.006415802,
-0.024351183,
-0.018368348,
0.01578366,
0.02360333,
-0.015665578,
0.0039590355,
-0.027631246,
-0.006665087,
-0.016203508,
-0.019890299,
0.0042968816,
-0.027132677,
-0.007970552,
0.0019762376,
0.023288444,
0.044871252,
0.010548681,
0.0035063867,
-0.0004915994,
0.040830217,
-0.0012152632,
0.036106925,
0.019168684,
-0.017436812,
-0.020100223,
0.015573736,
-0.022028899,
-0.008009912,
0.0008724966,
-0.0049725748,
-0.027421322,
-0.0023960855,
0.008003352,
0.027001474,
0.01897188,
0.000019449744,
0.010122272,
-0.004949614,
0.014497876,
-0.012437996,
-0.0079574315,
-0.015626216,
-0.032354534,
0.0020795595,
0.003206261,
-0.023708291,
-0.002938936,
-0.012451117,
-0.008206716,
0.00076876464,
0.01731873,
-0.01839459,
-0.0231966,
-0.0015473694,
-0.005674508,
-0.012182152,
-0.010647083,
-0.0025650088,
-0.0132711325,
0.013579458,
-0.008679045,
0.014550357,
-0.03791752,
0.019404849,
0.019772217,
0.011355576,
0.0067503685,
0.02213386,
-0.019706614,
-0.011191573,
-0.019772217,
0.008849609,
-0.009236656,
0.027290119,
0.031199953,
0.0047495305,
-0.02576817,
-0.0020615193,
-0.022698032,
-0.029835448,
0.0021156403,
0.0057630697,
-0.0038343929,
0.031488597,
-0.005927073,
0.0141042685,
0.019850938,
0.012877525,
-0.012661041,
-0.018224027,
0.0061304364,
-0.004103358,
0.013435136,
-0.002528928,
-0.012123111,
-0.009262896,
0.0473641,
-0.023983816,
-0.016019825,
-0.006504364,
-0.0022763633,
0.015416293,
-0.008895529,
0.023721412,
-0.00032452118,
0.009256336,
0.026424183,
-0.03156732,
-0.004362483,
0.000131715,
-0.0014350273,
-0.019247405,
0.01741057,
-0.0002781903,
-0.0048577725,
0.0007134136,
0.008475681,
-0.046524405,
0.014865243,
-0.0088168075,
0.038179927,
0.024180619,
-0.004779051,
0.01731873,
0.021766493,
-0.012372395,
-0.022474987,
-0.013277693,
-0.022356905,
0.0012259233,
0.0115983,
0.0019795178,
0.008633125,
-0.016492154,
-0.0058450713,
-0.024902234,
-0.015665578,
-0.010647083,
-0.010260035,
-0.025886253,
0.031278674,
-0.0037195908,
-0.018735716,
-0.0030225774,
-0.013881224,
-0.011453978,
0.008665925,
-0.0006059915,
-0.019378608,
-0.011696703,
0.005569546,
-0.018184666,
-0.00052193995,
-0.005877872,
-0.017987862,
-0.010712684,
0.0017827139,
0.03618565,
0.18126936,
-0.01369754,
0.006343641,
0.009302257,
0.01573118,
0.01264136,
0.0019696774,
0.003053738,
-0.008770887,
0.0030717785,
0.013959945,
0.0016875921,
0.016767679,
-0.0002259143,
0.025636967,
-0.02421998,
0.010535561,
0.02261931,
-0.019798456,
-0.03248574,
-0.011486778,
-0.020401988,
0.008265757,
0.011762303,
0.02057255,
-0.021346645,
-0.034007687,
-0.009131693,
0.009722105,
0.013815623,
-0.021071121,
0.017712336,
-0.01941797,
0.0037655116,
-0.002781493,
0.0043165623,
0.00028208536,
-0.018224027,
-0.0007089035,
0.0055957865,
0.018171545,
0.016072305,
0.0049627344,
0.013205531,
-0.005313701,
0.008318238,
0.0041952,
0.00074416416,
-0.003791752,
-0.021897696,
-0.056731958,
0.010148513,
0.023734532,
0.000013389317,
0.0019795178,
0.02049383,
0.011696703,
0.035529636,
-0.01577054,
0.004326402,
-0.027657486,
-0.008075514,
-0.036001965,
0.0015941103,
-0.009853307,
0.023472127,
-0.024980955,
-0.010922608,
0.01998214,
-0.021792734,
0.002520728,
-0.008652804,
-0.020231424,
-0.0003308763,
-0.01524573,
-0.008882409,
0.027106436,
0.004506806,
0.01889316,
0.019903418,
0.011703263,
0.0079574315,
-0.049804468,
0.0209924,
0.007622865,
-0.04266705,
0.023380285,
-0.004887293,
-0.022684911,
-0.016885761,
0.011145652,
-0.012267433,
0.006629006,
-0.021005519,
0.017423691,
0.0052349796,
0.022015778,
0.0072358176,
-0.012542958,
-0.029809207,
-0.032905586,
0.092156634,
0.013330174,
0.016964482,
0.010220675,
0.009584342,
-0.008305118,
0.000078208985,
-0.008246077,
-0.026411062,
0.0059237927,
-0.02315724,
0.02365581,
-0.026620986,
-0.011486778,
0.02048071,
0.018289628,
-0.03587076,
0.047521543,
-0.02374765,
-0.013061209,
-0.016400311,
-0.00045305863,
0.013284253,
-0.009787706,
0.01890628,
0.008652804,
-0.011716383,
-0.008200156,
-0.031383637,
0.0025617287,
-0.0045133657,
-0.019313008,
0.01312681,
0.0025420485,
-0.02252747,
-0.005316981,
-0.0065437243,
-0.0032981026,
0.017764818,
-0.01523261,
0.0036572695,
0.02101864,
0.014786521,
-0.0093809785,
-0.009604023,
0.023039158,
0.015048927,
-0.009715545,
-0.025650088,
0.00080156524,
-0.026948992,
0.0056318673,
0.013008728,
0.03206589,
-0.02841846,
-0.018578274,
-0.008823368,
-0.011198133,
0.003260382,
-0.028444702,
0.003981996,
0.010620842,
-0.003785192,
-0.0038868738,
-0.0020795595,
-0.1635308,
0.002889735,
0.026358582,
-0.041853596,
0.024639828,
0.0013874664,
-0.0013095649,
0.0049692946,
-0.0014440474,
0.010601162,
0.029258156,
0.014655319,
-0.020178944,
-0.030517701,
0.003893434,
0.003929515,
0.021805855,
0.03781256,
0.026109297,
-0.0016744719,
0.02206826,
-0.032774385,
0.01312681,
-0.005051296,
0.0024026458,
0.010338756,
0.032774385,
0.0010652003,
-0.015035806,
-0.020834956,
-0.007301419,
-0.0061829174,
0.0048216917,
-0.010082912,
-0.0008626564,
-0.003926235,
-0.006920932,
-0.01369754,
0.0061730775,
0.014078028,
0.030648902,
0.014983325,
0.011171892,
-0.012503598,
0.0037031905,
0.021950178,
-0.0031947808,
0.0055564255,
0.037104066,
-0.021818975,
0.008068954,
-0.014432275,
0.016452793,
0.014051788,
0.025164638,
0.0020631591,
0.004992255,
0.008357599,
0.005818831,
-0.0046084877,
-0.017830418,
-0.00420832,
0.024980955,
0.01207063,
0.007248938,
-0.02528272,
0.0068094097,
0.0053235414,
-0.02252747,
0.01948357,
-0.017633615,
-0.0051332978,
-0.008849609,
-0.019824697,
0.034401294,
0.010791405,
-0.021241684,
0.00420832,
-0.023288444,
0.0033850244,
-0.032249574,
0.013763142,
-0.029651765,
-0.022343785,
-0.00892833,
0.010312516,
0.022776753,
0.0061173164,
0.008731526,
0.00034317654,
0.0073276595,
-0.031252433,
0.015809901,
-0.009039852,
0.046340723,
0.024534866,
-0.032380775,
-0.0041689593,
-0.0071636564,
-0.0067634885,
-0.0005330101,
-0.011119411,
-0.0022042019,
0.02469231,
0.015324451,
0.012319914,
-0.008475681,
-0.015127648,
0.012602,
-0.009518741,
-0.010843886,
-0.0037655116,
0.014366673,
0.023026038,
0.0048020114,
0.03883594,
0.0048020114,
0.0025174478,
0.002829054,
-0.020113343,
0.09094957,
0.0020943198,
0.015468774,
0.03618565,
0.018184666,
-0.044293962,
-0.13959946,
-0.021386007,
-0.01472092,
0.037497673,
-0.0058483514,
0.0048020114,
0.0045133657,
0.043742914,
-0.0017023524,
0.026017455,
-0.010338756,
-0.019365488,
-0.0021320404,
-0.00682909,
0.008856168,
-0.019326128,
0.0051300176,
-0.0052382597,
-0.017069444,
0.03049146,
0.010469959,
0.00019803377,
-0.0010906208,
-0.010961968,
-0.009590902,
-0.004572407,
-0.03526723,
0.021215444,
0.0029356559,
0.025650088,
-0.002676531,
0.0024649668,
-0.002733932,
0.007635985,
-0.003365344,
-0.010633962,
0.017633615,
-0.016767679,
0.022015778,
-0.024980955,
-0.010371557,
0.015350692,
0.011736063,
0.016072305,
0.00944002,
-0.011447418,
0.0015596696,
0.016518394,
0.021897696,
-0.014865243,
-0.029914169,
-0.009761466,
-0.030727625,
-0.024561107,
0.009781146,
-0.009781146,
0.014510996,
0.002942216,
0.0076687858,
-0.004414964,
-0.0132711325,
0.00893489,
-0.010174753,
-0.0055433055,
0.017069444,
-0.021005519,
-0.021097362,
-0.027211398,
0.020913677,
-0.014287951,
0.00785247,
0.005408823,
-0.006140277,
0.005641707,
-0.008088633,
-0.0040311967,
0.003627749,
-0.0127069615,
-0.006140277,
0.0027962532,
0.008003352,
-0.01835523,
-0.0022206022,
-0.02999289,
0.042194724,
-0.0028667746,
0.019221166,
-0.012982487,
0.022737393,
0.0012931646,
-0.004372323,
0.047521543,
-0.014392913,
-0.0013399054,
-0.019798456,
0.008980811,
-0.010410918,
-0.016977603,
0.015744299,
0.026516024,
-0.024482386,
-0.009335058,
-0.03896714,
0.008560963,
0.0273426,
-0.0016523314,
-0.0033046629,
-0.013907464,
-0.0007154636,
-0.019365488,
-0.0024830073,
0.017974742,
-0.016439673,
-0.00019567623,
-0.002774933,
-0.021399127,
-0.026975233,
-0.022540588,
0.014550357,
-0.012352715,
0.01848643,
0.02414126,
-0.010916048,
0.024115019,
0.009663064,
-0.0013390855,
-0.009610583,
0.005366182,
-0.027290119,
0.018985001,
-0.015140768,
-0.014602838,
0.012943126,
-0.044845015,
-0.016216628,
0.005982834,
-0.025308961,
0.0016203509,
-0.00012505238,
0.015285091,
0.020821836,
0.035818283,
-0.0076097446,
-0.036001965,
0.020874318,
-0.010857007,
-0.011991908,
0.026043694,
-0.011526139,
0.003775352,
-0.00058016105,
-0.011506459,
0.050854087,
0.0091382535,
-0.004149279,
-0.03041274,
0.015823022,
-0.020926798,
0.014839002,
0.0029586162,
-0.0262405,
-0.018919399,
0.013290813,
0.030753866,
0.015193249,
0.0026912913,
-0.022540588,
-0.018552033,
-0.03327295,
0.009046412,
0.0011513019,
-0.035687078,
0.007603185,
0.024023177,
0.02894327,
0.0052284193,
0.015665578,
-0.013526977,
-0.041328788,
-0.011080051,
-0.013828743,
0.021359766,
0.014274832,
0.0094334595,
-0.00085937633,
0.00736046,
0.046183277,
0.000894637,
-0.013907464,
0.02739508,
0.016898882,
-0.008705285,
-0.011421178,
-0.0032243014,
0.0060189143,
0.005208739,
0.011768864,
0.0069799726,
-0.0037523913,
0.020703753,
-0.0050381757,
-0.0050676963,
-0.0050676963,
0.006163237,
0.013428575,
-0.013763142,
6.310276e-7,
0.020598792,
-0.020939918,
-0.029546803,
-0.005681068,
-0.0032718622,
0.020743115,
0.015652457,
0.0058057103,
-0.0064748432,
-0.022737393,
0.021832095,
-0.026568506,
0.004575687,
0.0026142097,
0.014615958,
0.013330174,
0.009020171,
-0.0045133657,
0.014143629,
0.02205514,
0.006783169,
0.014839002,
-0.024534866,
0.036920384,
-0.0042936015,
0.024456145,
-0.025978094,
-0.030622663,
-0.012556079,
-0.019509811,
-0.011781984,
0.023406526,
0.010771725,
-0.019706614,
0.07573008,
0.008849609,
-0.013579458,
-0.0117951045,
-0.0050020954,
0.011841025,
-0.0025994494,
0.018447071,
-0.026896512,
-0.020283906,
0.013343294,
-0.026516024,
0.022960437,
-0.025571367,
0.009052972,
0.022330664,
-0.009098893,
0.026870271,
0.00043009818,
-0.015744299,
0.003467026,
-0.018578274,
0.0048610526,
0.013054648,
-0.025125278,
0.00041431288,
0.049305897,
0.00035404172,
0.014812762,
-0.042876974,
0.008055833,
-0.0048118513,
-0.03408641,
-0.019063722,
0.02360333,
-0.00842976,
-0.0045363265,
-0.041276306,
0.0046084877,
0.017725457,
-0.0049791345,
0.0011103011,
-0.009262896,
-0.025532005,
-0.006356761,
-0.0076491055,
0.0077015865,
-0.01001075,
-0.00035076166
] |
Little is known about the changes in white blood cells and platelets in children with falciparum malaria in endemic areas. We measured the white cell count (WCC) and platelets of 230 healthy children from the community, 1369 children admitted to hospital with symptomatic malaria, and 1461 children with other medical conditions. Children with malaria had a higher WCC compared with community controls, and leucocytosis was strongly associated with younger age, deep breathing, severe anaemia, thrombocytopenia and death. The WCC was not associated with a positive blood culture. In children with malaria | [
0.005782502,
0.01789054,
0.012098165,
-0.036123358,
-0.009570584,
0.018088007,
-0.011597915,
-0.010867286,
-0.013954358,
-0.0074116075,
0.015547262,
0.029067192,
0.011367536,
0.014112333,
0.0063354103,
0.016560927,
0.044627618,
-0.0105447555,
-0.018009022,
-0.016139664,
-0.009070333,
0.026552774,
-0.012980186,
-0.023011528,
0.0066809785,
0.016310802,
0.008458184,
-0.024709746,
0.0119401915,
-0.02290621,
0.031015536,
-0.019167496,
0.0057759196,
-0.0051538977,
-0.026407965,
-0.02424899,
0.032832235,
-0.017587757,
0.012591834,
0.008102743,
0.011696649,
0.030094022,
-0.002234672,
0.010090581,
0.0005031303,
0.015771057,
0.009340205,
0.02601303,
-0.022458619,
0.02642113,
0.0028863142,
-0.014954859,
0.019457115,
0.0021639129,
-0.02434114,
-0.014007016,
0.015705235,
0.010827792,
-0.0064966753,
-0.028435297,
0.023880383,
0.0072207223,
-0.02243229,
-0.009768051,
0.0047490895,
0.0054994654,
0.0138622075,
0.024091015,
0.023669751,
0.026355308,
0.042600285,
0.028224666,
0.011630827,
-0.015060175,
0.017956363,
-0.016824218,
-0.030594273,
0.010893615,
-0.017719403,
-0.001420942,
0.018864714,
-0.006885028,
-0.036386646,
0.011426777,
0.009136155,
-0.0016867002,
0.01184804,
0.018535601,
-0.0047227605,
0.0118546225,
-0.011604497,
0.020747235,
0.010906779,
0.000052760803,
0.025262654,
0.0023498612,
-0.0027365682,
0.029304152,
0.015033847,
-0.014059674,
-0.025288984,
-0.0034030206,
-0.010781717,
-0.008293628,
-0.025644425,
0.0019993568,
-0.00650984,
0.008392362,
0.013243476,
-0.024854556,
-0.0199442,
0.03657095,
0.016402954,
-0.04354813,
-0.0016027766,
-0.006302499,
-0.015784223,
0.012624745,
-0.008023757,
-0.0025209996,
0.014125497,
-0.004758963,
0.027118847,
-0.0005088898,
0.008971599,
0.013730562,
-0.021945203,
-0.015323466,
-0.024235824,
-0.02049711,
-0.007589328,
0.0017163203,
0.0118546225,
-0.00979438,
-0.00015272864,
0.0115320925,
-0.015797388,
-0.0006347752,
-0.0407046,
0.005617946,
0.008602994,
0.028172007,
0.000018641122,
-0.02785606,
0.0009025903,
0.013124996,
0.019812556,
0.017587757,
-0.005976678,
-0.028803902,
-0.005114404,
-0.014994353,
0.035412475,
0.00797768,
0.00056113634,
-0.0015221441,
-0.0023383424,
0.019667746,
-0.04560179,
-0.015047011,
-0.028487954,
0.0071943933,
0.0064111063,
-0.007181229,
0.0014538533,
0.0138622075,
-0.0075300876,
-0.0018249273,
0.01879889,
-0.016376624,
-0.008431856,
0.046470646,
-0.00797768,
0.016416118,
-0.009432357,
-0.006213639,
-0.0082804635,
0.018232817,
-0.021050017,
-0.0296201,
-0.034122355,
0.0407046,
0.017140165,
-0.012591834,
-0.0023877092,
-0.00953109,
0.032911222,
-0.0052625043,
0.004439724,
0.016310802,
0.0065526245,
0.02386722,
0.0013600563,
-0.020602426,
-0.6580138,
-0.00595364,
0.00011806901,
0.011150322,
0.021365967,
0.0018018895,
0.028066691,
-0.012506264,
-0.02885656,
0.015626248,
0.006727054,
0.016916368,
-0.005223011,
-0.024907213,
0.0033997293,
-0.031805407,
-0.02424899,
-0.00985362,
0.009116408,
-0.010353871,
-0.021550268,
0.007997427,
0.018548766,
0.023498613,
-0.029699087,
-0.0055356678,
0.03604437,
-0.0021474573,
-0.009636406,
0.021194827,
-0.003281249,
0.03201604,
-0.0028484664,
0.02909352,
0.045443818,
-0.028487954,
0.008760967,
0.02128698,
0.010972601,
0.028435297,
-0.015270808,
-0.0074445186,
0.029962378,
-0.009070333,
-0.0147310635,
0.014270307,
-0.007240469,
0.01545511,
-0.0067336364,
-0.003419476,
-0.0011543612,
-0.0112424735,
-0.006368322,
0.018812055,
-0.005068328,
0.003449096,
0.014336129,
-0.0044792173,
-0.012802466,
0.0006923698,
-0.017469278,
-0.0057759196,
0.010768552,
-0.015731564,
0.0110845,
0.0044594705,
-0.0085635,
0.014415116,
0.022419125,
-0.011308297,
0.018983193,
0.02061559,
-0.017864212,
0.011755889,
0.0112424735,
0.008734639,
0.018219654,
-0.0069574327,
-0.028540613,
0.01729814,
0.004627318,
0.015915867,
-0.009787798,
0.0038637775,
0.030330984,
0.00014624925,
-0.015586755,
0.002463405,
0.01442828,
0.0015015745,
0.013026262,
0.016310802,
0.0025473286,
-0.031542115,
-0.0021030272,
0.00953109,
-0.01891737,
-0.028514283,
0.026407965,
-0.025697082,
-0.029330483,
-0.014928531,
0.006970597,
-0.010110328,
0.0056344015,
0.0030475792,
-0.04404838,
-0.025104681,
0.04383775,
-0.0350702,
0.0025917587,
0.0019006231,
0.0015098023,
-0.016732065,
0.022998363,
-0.015165492,
0.0074116075,
0.01307892,
-0.014415116,
-0.023761902,
0.012203481,
0.035465132,
0.021537105,
-0.0278034,
-0.0012127786,
-0.012802466,
-0.0023975826,
-0.0031331484,
0.009603495,
-0.03396438,
0.007286545,
-0.011420194,
0.043205854,
-0.015468275,
0.04773444,
-0.030041365,
0.03270059,
-0.0066842693,
0.009728557,
-0.01961509,
-0.009195396,
-0.004304788,
0.028672257,
-0.009215143,
0.0009363243,
-0.01184804,
0.00052657956,
-0.0014826506,
-0.0278034,
0.0074511007,
-0.0075761634,
-0.023090513,
-0.014112333,
0.008958435,
-0.0017525227,
-0.0039460557,
-0.0061181965,
-0.017837882,
-0.010603996,
-0.025078353,
0.007181229,
0.0029422634,
0.011992849,
0.004900481,
0.011189816,
-0.0062103476,
0.00036572595,
0.009498179,
0.013612082,
-0.022853553,
0.013408032,
-0.026342142,
-0.0077078086,
0.019904708,
0.0072009754,
0.017930035,
-0.013480437,
-0.0038901065,
-0.01970724,
0.012183735,
-0.0023613803,
-0.016376624,
-0.006325537,
0.00086145126,
0.01598169,
0.012967022,
0.019957365,
0.01170323,
0.00000572411,
0.052473653,
-0.0062235123,
0.00063724356,
-0.03301654,
0.007339203,
0.01841712,
-0.010044505,
-0.010083999,
0.0074642655,
0.0043475726,
0.042652946,
-0.006039209,
0.010840957,
0.015560426,
0.0009815772,
0.028487954,
-0.03791373,
-0.0016430928,
-0.0033997293,
0.028566942,
0.029725416,
0.0026855557,
-0.0055323765,
0.0010005012,
-0.0030607437,
-0.0010926526,
-0.0071746465,
-0.00076271757,
-0.015033847,
0.006388068,
-0.00059939566,
0.008129072,
-0.007286545,
0.039835744,
0.008319957,
-0.0041073207,
-0.013368539,
0.029567443,
0.035939056,
0.017100671,
0.009254636,
-0.015047011,
0.0064242706,
0.005545541,
-0.0024831519,
0.0015056884,
0.0076288213,
0.017745731,
-0.019641418,
0.012690567,
0.021418624,
-0.009544254,
0.018956864,
0.0061445255,
-0.0066612316,
0.021431789,
-0.008997928,
0.031621102,
-0.004739216,
-0.019891543,
0.042626616,
0.011209562,
0.018956864,
-0.03378008,
0.01583688,
-0.005696933,
-0.014125497,
-0.004946557,
0.012137659,
0.010972601,
0.023261653,
0.027382137,
-0.012473353,
0.008734639,
-0.016429283,
0.0000058590977,
-0.0006878446,
0.0070364196,
-0.019457115,
-0.008254135,
0.0021441663,
-0.043442816,
-0.0031413762,
0.017758897,
-0.02603936,
-0.008372615,
-0.00071252795,
0.013197401,
-0.009320458,
0.004660229,
0.0051835175,
-0.0035478298,
-0.0155999195,
0.004847823,
0.02152394,
-0.027698085,
-0.025999866,
-0.032121353,
0.022629756,
-0.021892546,
0.011808547,
-0.008681981,
0.013954358,
-0.0052098464,
-0.009083497,
-0.009636406,
-0.019088509,
0.009978683,
-0.004758963,
0.02615784,
0.0052723777,
-0.013717398,
0.00011518928,
-0.014941695,
-0.004143523,
0.0053118714,
0.013480437,
-0.01378322,
-0.0012012597,
-0.008695145,
0.012177153,
0.0013477146,
-0.03251629,
0.007049584,
0.036491964,
-0.013467273,
0.010399946,
-0.0060885763,
0.027908716,
0.0074905944,
-0.004712887,
-0.027276821,
-0.028777573,
-0.017337631,
-0.035491463,
0.047760766,
0.006111614,
-0.0002717233,
0.007865782,
0.012604998,
-0.0041994723,
-0.0070890775,
-0.022169,
0.029198837,
0.0021540395,
-0.015929032,
-0.009491596,
0.024156837,
0.014243977,
-0.009491596,
0.013651575,
-0.003850613,
-0.0067928764,
-0.0153103005,
0.026697583,
0.0153103005,
0.009695646,
0.027145177,
0.046523307,
0.014823215,
0.009840456,
0.0048379498,
0.021458117,
-0.010314377,
0.011637408,
-0.011762471,
0.007753884,
0.005871362,
0.005282251,
0.003955929,
-0.014889037,
-0.010650071,
-0.009926025,
0.01700852,
0.0008482868,
0.039783087,
0.013454108,
-0.0047556716,
-0.0022445454,
0.019364964,
0.0028813775,
0.011518928,
0.013375121,
0.002107964,
-0.04581242,
0.04565445,
0.0062366766,
0.0047787097,
-0.01366474,
0.015560426,
0.013039427,
-0.0045285844,
-0.0021737863,
0.0138622075,
0.017587757,
-0.02369608,
-0.018338133,
0.011676902,
0.0031825153,
-0.019430786,
-0.0007458506,
0.0045549134,
-0.01454676,
-0.04307421,
-0.022129506,
-0.023353804,
-0.010992348,
-0.021063183,
-0.0012391076,
0.0056409836,
0.017087506,
0.018193323,
-0.018193323,
-0.008254135,
0.015652578,
-0.018535601,
0.0075695813,
0.00062449044,
-0.020378629,
0.017745731,
-0.0017591049,
0.012730061,
0.014086003,
-0.02331431,
0.0072536333,
-0.015520933,
0.006269588,
0.009939189,
0.00094290654,
-0.0017393582,
0.010742223,
-0.0002196824,
0.017600922,
-0.024578102,
-0.0048840255,
0.008306793,
-0.04275826,
-0.010709312,
0.009228307,
-0.009932607,
0.003495172,
-0.02434114,
-0.0012234747,
-0.026960874,
-0.027434796,
-0.0029570733,
-0.029830733,
0.023682917,
0.018285476,
0.00941261,
0.04847165,
0.00721414,
0.0012991705,
0.057449833,
-0.029014533,
0.006588827,
-0.0016101815,
0.013717398,
-0.0083989445,
-0.01979939,
0.008346286,
0.009833873,
-0.017048014,
-0.029962378,
-0.007240469,
0.0057759196,
0.02486772,
0.008616158,
0.0015501186,
-0.024801897,
0.0018463196,
0.005548832,
0.00003856784,
-0.006536169,
0.0029109977,
-0.009840456,
0.0114465235,
-0.0035379564,
-0.020483945,
0.028066691,
-0.024854556,
-0.000040007704,
-0.015152327,
-0.010979184,
0.0076024923,
-0.007819707,
-0.007187811,
-0.023103679,
-0.00027995108,
-0.005413896,
-0.018772561,
-0.0011667028,
-0.014178155,
0.029409468,
-0.0031134016,
0.025960373,
-0.007905276,
0.042442314,
-0.003090364,
-0.019035852,
-0.008695145,
0.010413111,
0.017087506,
0.0032598567,
0.01020248,
0.016350295,
-0.004215928,
-0.011123993,
0.00009292278,
0.021800393,
0.048603293,
-0.011380701,
-0.008780714,
-0.001608536,
-0.022827225,
-0.011815129,
0.007846036,
0.0056475657,
0.024301646,
-0.023143172,
-0.012512847,
0.01979939,
-0.011683485,
-0.004679976,
-0.016969027,
0.014230813,
-0.0006993635,
-0.000669332,
-0.02577607,
-0.001541068,
0.0075432523,
-0.009248054,
0.012868288,
-0.015784223,
0.019891543,
0.0084845135,
0.0022906212,
0.005005797,
-0.0035280832,
-0.024433292,
0.006838952,
-0.015231314,
-0.023274817,
0.00027151758,
-0.014415116,
-0.012506264,
-0.0073655318,
-0.008214641,
-0.029198837,
-0.01700852,
-0.0029916302,
-0.019957365,
0.01366474,
-0.004920228,
-0.020154834,
0.020128503,
-0.011676902,
0.005242758,
-0.031357814,
0.045285843,
0.0074445186,
-0.009037422,
-0.030567944,
-0.025012529,
-0.007813124,
-0.0006438258,
0.03862461,
0.03380641,
-0.05797641,
0.009899695,
0.011045006,
0.021273814,
0.007615657,
-0.016087005,
0.005509339,
0.005005797,
-0.014020181,
-0.0134211965,
0.0027612515,
-0.033595778,
0.013967523,
0.0047688363,
-0.023880383,
0.025618097,
-0.021616092,
-0.0011321461,
0.0012267658,
-0.017956363,
0.016297638,
-0.02255077,
0.01128855,
0.01636346,
-0.021089511,
-0.032121353,
0.01114374,
-0.0049564303,
0.017113836,
-0.008807044,
-0.011499181,
0.015323466,
-0.000076415745,
0.0058944,
0.008115907,
-0.023130007,
0.044338,
0.010340706,
-0.00023901775,
0.014270307,
0.006141234,
-0.0016192321,
-0.008175148,
-0.0061280695,
-0.020286478,
-0.028119348,
0.0042422567,
0.022458619,
0.015099669,
-0.021905709,
0.0010531591,
-0.03040997,
0.0035774498,
-0.019180661,
-0.027777072,
0.009787798,
-0.03991473,
-0.0066085737,
0.007846036,
0.00008731759,
0.011163487,
-0.013427779,
-0.025433794,
-0.025460122,
0.015468275,
-0.011301714,
0.016903205,
0.021392295,
0.0033701092,
-0.014375622,
0.0008894258,
-0.0041040294,
-0.019549266,
-0.0023761904,
-0.007819707,
-0.021063183,
-0.0009404382,
-0.017732566,
0.011505764,
-0.0069574327,
-0.019035852,
0.008451602,
0.029198837,
0.0063716127,
-0.007293127,
-0.0022544188,
0.022879882,
-0.01985205,
-0.008556918,
0.031331483,
-0.00035379565,
-0.009280965,
-0.004600989,
-0.002504544,
0.00864907,
-0.003442514,
-0.008833372,
-0.014994353,
0.026473789,
-0.005413896,
0.0070100906,
-0.024038358,
-0.013375121,
-0.0023465701,
0.004627318,
0.013197401,
-0.007813124,
0.013572589,
-0.020062681,
-0.002047078,
0.008030338,
-0.016139664,
0.0090637505,
0.015283972,
-0.025209997,
-0.03509653,
0.013289552,
-0.010136656,
0.026723914,
-0.0124931,
-0.0037189682,
-0.022221658,
-0.009860203,
-0.04531217,
-0.008089579,
-0.0053447825,
0.0070824954,
0.009241471,
0.016771559,
0.009261218,
0.009827292,
0.010610579,
0.006105032,
-0.025815563,
-0.017127,
0.0060951584,
0.006727054,
0.0136252465,
-0.013585753,
-0.028119348,
-0.0003391913,
0.039519798,
-0.015323466,
-0.00876755,
0.015033847,
-0.013822714,
0.00018965092,
-0.033358816,
0.021510776,
-0.016021183,
-0.0031578317,
-0.015283972,
-0.013263223,
-0.018403957,
-0.0053447825,
0.0046207355,
-0.008471348,
0.00041324153,
0.024946706,
-0.017574593,
-0.014717899,
-0.043495473,
-0.020681413,
0.018022185,
-0.03346413,
0.010834374,
0.0018693574,
-0.026737077,
0.012762972,
0.011617661,
0.027118847,
0.013190818,
0.0069837617,
0.0017607504,
0.004844532,
0.0074971765,
0.0085635,
-0.014336129,
0.012275886,
-0.0085700825,
-0.01457309,
0.000021765118,
-0.0061181965,
-0.0030722627,
-0.025973538,
0.021313308,
-0.0014349293,
-0.018996358,
0.0018989776,
0.009695646,
-0.01392803,
-0.020325972,
0.0054500983,
-0.002084926,
-0.012703732,
-0.0005578452,
-0.0029422634,
-0.0139017,
0.002542392,
0.014480938,
0.004248839,
0.00031697622,
-0.0021491027,
0.17808922,
0.014954859,
0.005301998,
0.012137659,
-0.004656938,
-0.011499181,
0.04038865,
-0.0016340422,
0.010077417,
0.013092085,
0.027039861,
-0.0035873232,
-0.0024255572,
0.005858198,
-0.023248488,
-0.0051901,
-0.04178409,
-0.011380701,
0.00077176816,
-0.031094523,
-0.016258145,
-0.0037189682,
0.00812249,
-0.0031808696,
0.003220363,
-0.0025242907,
-0.017666744,
0.0029718834,
0.026236827,
0.0037387148,
-0.008537171,
0.01891737,
-0.042152695,
0.0042916234,
-0.01777206,
-0.018456614,
-0.0071417354,
-0.00092974206,
-0.0003097769,
0.0015353085,
-0.0039921314,
-0.000661927,
-0.013691069,
0.007674897,
-0.023656586,
0.033595778,
0.00044759264,
-0.01683738,
0.0012078419,
0.0017327759,
-0.027540112,
-0.012315379,
-0.010656654,
0.012256139,
-0.006295917,
-0.00621693,
0.0063452837,
0.01469157,
-0.02677657,
0.010097163,
-0.008668816,
-0.00032047305,
-0.011505764,
0.0415208,
-0.0044331416,
0.03575475,
-0.014862708,
0.008609576,
-0.022261152,
-0.008681981,
0.005058455,
-0.021273814,
0.0054007317,
0.010169568,
-0.014744228,
-0.013263223,
0.022076849,
0.015797388,
-0.017179659,
-0.0057989573,
0.0013691068,
-0.009511343,
-0.02988339,
0.01595536,
-0.0039658025,
-0.035939056,
0.0028270741,
0.02381456,
-0.04128384,
-0.028014032,
0.005301998,
0.002088217,
-0.010399946,
-0.0022478364,
0.00864907,
0.009274383,
0.010393364,
-0.009109827,
-0.017048014,
-0.014257141,
-0.027513782,
0.07603809,
-0.0073062913,
0.014257141,
-0.0021013815,
0.010452605,
-0.010314377,
0.013756891,
-0.006430853,
0.011163487,
-0.0065855356,
-0.04178409,
0.0053118714,
-0.017732566,
0.0012382847,
0.014151826,
0.008642487,
-0.009221724,
0.020536603,
-0.006295917,
-0.002460114,
-0.023472285,
0.03633399,
0.034359317,
-0.019917872,
-0.0023087224,
-0.019404458,
0.007326038,
0.013223729,
-0.027118847,
-0.003791373,
-0.044785593,
-0.01762725,
0.004959721,
-0.018509272,
0.008543753,
-0.004169852,
0.0009988556,
0.009057169,
0.0029653013,
0.011354372,
-0.020246984,
0.006917939,
-0.01519182,
-0.011545257,
0.00022400201,
0.019733569,
0.013967523,
-0.026473789,
-0.011518928,
-0.011492599,
-0.025604932,
-0.012999933,
-0.016587256,
0.022853553,
-0.02008901,
0.00689161,
-0.0006142057,
0.03375375,
-0.012032343,
-0.029330483,
0.013638411,
0.007635404,
0.010669818,
0.011795382,
0.002894542,
-0.16566193,
0.017877376,
-0.0082804635,
-0.014783721,
0.025302147,
0.017614087,
-0.0078723645,
0.009017675,
-0.011123993,
0.0025127719,
0.021076348,
-0.0016266372,
-0.0100510875,
0.006898192,
-0.0022182164,
-0.013849042,
-0.02993605,
0.039519798,
0.031120852,
0.0031825153,
0.051130876,
0.0037255504,
0.002020749,
-0.005683768,
0.016758395,
0.009491596,
-0.001987838,
0.009109827,
-0.0069837617,
-0.018048516,
-0.015086505,
-0.007661733,
0.007681479,
0.0021293561,
-0.023116844,
-0.008708309,
-0.020075846,
-0.0022330265,
0.012710314,
0.008780714,
0.03299021,
-0.0035412477,
-0.0005047759,
0.005404023,
-0.0040480806,
0.05444833,
0.0075695813,
-0.009899695,
0.015613084,
0.0031627684,
0.013276387,
-0.010564502,
0.009827292,
0.00876755,
-0.0053513646,
-0.004709596,
0.005410605,
-0.015441946,
0.021800393,
-0.002410747,
-0.002647708,
-0.020655084,
0.0016644851,
-0.014586254,
0.019417621,
-0.011663738,
0.0026312522,
0.022116343,
-0.010209061,
0.012940693,
-0.021484446,
-0.033332486,
0.0046733934,
-0.005456681,
0.020918373,
0.018746233,
-0.014875873,
-0.005120986,
-0.015047011,
0.02026015,
-0.01944395,
0.0296201,
-0.016416118,
0.0047820006,
-0.010873868,
-0.005084784,
-0.0011601206,
0.024657087,
-0.016271308,
-0.024683418,
-0.00025629616,
-0.026855558,
-0.00065081945,
-0.032358315,
0.01748244,
0.023130007,
-0.026895052,
0.010070834,
-0.0032368188,
0.006838952,
0.024801897,
-0.010715894,
-0.0296201,
-0.011959938,
0.029593771,
-0.01043944,
0.014849544,
0.013236894,
0.035649437,
-0.0032746666,
0.0010482224,
0.0054599717,
-0.0019269522,
0.007944769,
-0.0018512562,
0.01856193,
0.017495606,
-0.01469157,
0.007806542,
-0.011690066,
0.04454863,
-0.0064670555,
-0.008050085,
0.027434796,
-0.016402954,
0.017706238,
-0.13406716,
0.019878378,
-0.014257141,
0.01237462,
0.0008166097,
0.015705235,
-0.025381135,
0.018469779,
0.012137659,
0.014007016,
-0.016521433,
-0.0103802,
-0.016560927,
0.011183234,
0.045417488,
0.012664239,
0.01803535,
-0.0011008804,
-0.01662675,
0.04020435,
0.0122298105,
-0.013480437,
-0.0045911158,
-0.023445955,
0.01011691,
-0.01158475,
-0.020747235,
0.0207604,
0.0026641635,
0.025354806,
0.018048516,
0.0021622675,
0.011775635,
-0.028408967,
-0.015744729,
-0.002534164,
-0.026842393,
-0.00941261,
0.0011469561,
-0.030646931,
0.0033404892,
0.0154287815,
-0.011347789,
-0.03604437,
0.023643423,
0.006924521,
-0.01979939,
-0.0028879598,
0.0149022015,
-0.042916235,
0.0055850344,
-0.041942064,
-0.031199839,
-0.0129275285,
0.0019829012,
-0.009504762,
-0.009392863,
0.025907714,
-0.010037923,
-0.0017130291,
-0.010044505,
0.00015077453,
-0.021747736,
0.034043368,
0.019246483,
-0.0010951209,
-0.013967523,
-0.0030015034,
0.01457309,
-0.028487954,
-0.010913362,
0.001593726,
-0.01985205,
-0.009024258,
-0.008839955,
0.016113335,
-0.017877376,
-0.0072273044,
-0.016021183,
-0.022511277,
-0.009300712,
0.008728056,
-0.0079579335,
0.0071614822,
0.028751245,
0.03280591,
0.010933109,
-0.006026045,
0.004765545,
0.016639914,
-0.017061178,
0.010189314,
0.0071088243,
-0.017956363,
-0.0016463839,
0.022142671,
-0.011637408,
-0.037676767,
-0.000073176045,
-0.0038868154,
-0.0069047743,
-0.03322717,
-0.03765044,
0.01662675,
0.006730345,
-0.0022412543,
0.0011955001,
-0.0032483377,
0.0110713355,
-0.005269087,
0.021537105,
0.019878378,
-0.023761902,
0.012131076,
-0.027276821,
0.0028747953,
-0.019193824,
0.0136252465,
0.0037847906,
0.010261719,
0.025986701,
0.021576598,
-0.021905709,
-0.0057989573,
0.0082804635,
0.010492098,
0.026355308,
-0.0015065112,
0.0039954223,
0.022129506,
-0.010597413,
0.005838451,
0.01281563,
-0.041836746,
-0.002422266,
-0.0023334057,
-0.0041336496,
-0.023524942,
-0.00460428,
0.017232316,
0.017113836,
0.010222225,
-0.016732065,
0.0107488055,
0.023301145,
-0.01469157,
-0.002167204,
0.02295887,
-0.026105182,
0.032779578,
-0.0075564166,
0.012236393,
0.033727422,
-0.0032664388,
0.010123492,
-0.023432791,
-0.017456112,
0.012855124,
-0.025710247,
-0.0022001152,
0.022471784,
-0.0231695,
0.016771559,
0.00083388813,
-0.00029023585,
-0.009807545,
-0.007694644,
-0.01093969,
0.011775635,
0.021392295,
-0.004979468,
-0.01662675,
0.0025555564,
-0.008372615,
0.012618163,
0.025907714,
0.0029488455,
0.020681413,
0.0007289836,
0.017851047,
0.0073852786,
0.035623107,
0.0042126365,
-0.0002628784,
-0.045443818,
0.001762396,
0.019180661,
0.00148841,
-0.005489592,
0.01586321,
-0.018443448,
0.03530716,
-0.01660042,
0.008714892,
-0.00053233904,
0.012289051,
-0.009320458,
0.033385143,
-0.0023745447,
-0.0041665607,
0.024657087,
0.048050385,
-0.018548766,
-0.00023346399,
0.006964015,
-0.027935047,
-0.00056278193,
-0.01017615,
-0.021339636,
-0.035886396,
0.001638979,
0.008971599,
0.019628253,
0.015586755,
-0.013941194,
-0.0011724624,
-0.004571369,
-0.0038901065,
0.012460189,
0.029593771,
-0.0314368,
0.017219152,
-0.016442446,
0.008221223,
0.0010630325,
-0.016152829,
0.0020668248,
-0.013105249,
0.019430786,
-0.003794664,
0.028461626,
0.00085240067,
0.00032088443,
0.017824719,
-0.048340004,
0.005644275,
0.019417621,
-0.010906779,
0.030462628,
0.0018775853,
0.0003307578,
0.062399678,
-0.006430853,
-0.026710749,
-0.007319456,
-0.016442446,
0.0021951785,
0.0050749104,
-0.012822213,
0.019391293,
-0.02281406,
0.011486017,
-0.004209345,
0.03248996,
-0.039572455,
-0.050920244,
0.009366534,
-0.004301497,
0.008010591,
-0.009741722,
-0.0052131377,
0.022629756,
-0.006595409,
0.02424899,
0.014401951,
-0.009142738,
-0.011736142,
0.016929533,
-0.018364463,
-0.009886531,
-0.011058171,
-0.0117690535,
0.00092891924,
-0.04128384,
-0.022234822,
0.0067533827,
-0.02422266,
0.009689064,
-0.030015035,
0.006727054,
0.014757392,
-0.004679976,
0.012460189,
-0.02137913,
-0.005624528,
-0.016139664,
-0.031384144,
-0.012262722,
-0.02023382,
-0.016587256
] |
There is currently great interest in molecular therapies to treat various diseases, and this has prompted extensive efforts to achieve target-specific and controlled delivery of bioactive macromolecules (for example, proteins, antibodies, DNA and small interfering RNA) through the design of smart drug carriers. By contrast, the influence of the microenvironment in which the target cell resides and the effect it might have on the success of biomacromolecular therapies has been under-appreciated. The extracellular matrix (ECM) component of the cellular niche may be particularly important, as many diseases and injury disrupt the normal ECM architecture, the cell adhesion to ECM, and | [
-0.02283046,
-0.0010896799,
0.0061301603,
-0.01336544,
-0.0010287359,
0.016238749,
-0.0065104514,
-0.0073197884,
-0.031775422,
-0.007924354,
0.021023266,
-0.008509417,
0.0011831275,
0.019684121,
-0.00054443366,
0.0033348594,
0.043554693,
-0.0075018085,
-0.026496856,
-0.0036371418,
-0.03463573,
0.031801425,
-0.008054368,
-0.011720763,
-0.010726156,
0.034843754,
0.026860895,
-0.041448466,
-0.020165173,
-0.018318973,
-0.009269998,
0.009770553,
-0.032451496,
-0.0059351395,
-0.004517987,
0.016134739,
0.0071247676,
-0.0031154607,
0.020841245,
-0.007306787,
0.02894112,
0.012819381,
0.010030581,
0.008320897,
-0.0052200626,
-0.016199745,
-0.003377114,
-0.015302649,
-0.011655756,
0.00185595,
0.0026912899,
0.0034258692,
-0.022219393,
-0.025053699,
-0.018084949,
-0.006331682,
-0.014990615,
-0.0004684567,
0.03164541,
-0.008769445,
-0.018357977,
0.0027156675,
-0.019099059,
-0.004986037,
-0.01746088,
0.009426015,
-0.0045927446,
0.018149955,
0.0032991054,
0.013098911,
0.015146632,
0.0148476,
0.009549529,
0.024195608,
0.0042287055,
-0.028473068,
-0.033751637,
0.0143145425,
-0.00091741135,
0.008899459,
0.00056271686,
-0.0020265933,
-0.0025726522,
0.026652873,
0.003601388,
0.009035974,
-0.0013919625,
-0.001893329,
0.013092411,
0.015822705,
0.020529212,
0.009543028,
-0.014977613,
0.01308591,
-0.011051191,
0.019528104,
0.003676146,
0.028889112,
0.0021046018,
-0.01820196,
-0.0065364544,
0.026782885,
-0.033075564,
-0.022284402,
-0.03406367,
0.007443302,
0.000582219,
-0.0027871754,
0.018995047,
0.005506093,
-0.023649547,
0.030137246,
-0.0128713865,
-0.029123139,
0.010830167,
-0.00030187628,
0.0154456645,
-0.012000293,
0.013293932,
-0.0052980706,
0.004687005,
0.030579295,
0.026561862,
-0.032529503,
0.02218039,
0.009263498,
-0.012390335,
-0.0072872853,
-0.013124914,
0.007118267,
0.0027725487,
0.014496562,
0.004391223,
0.022037374,
-0.02803102,
0.0010246729,
-0.019346084,
-0.018644009,
-0.029149141,
-0.039212223,
0.007963358,
0.03962827,
-0.021595327,
0.0043002134,
-0.011447733,
0.017655902,
0.03705399,
0.012929893,
0.017564893,
0.01086267,
0.013495454,
-0.010550637,
0.006377187,
0.004742261,
-0.012968897,
0.018579002,
-0.015172634,
0.01800694,
-0.0125398515,
0.00021939864,
0.014561569,
-0.0066404655,
0.023922578,
0.0120718,
0.052499656,
0.016238749,
0.013313434,
0.007222278,
0.0129233925,
-0.005038043,
-0.012507347,
0.019892143,
-0.02366255,
0.01475659,
-0.027875002,
0.018904036,
0.0018982046,
0.03593587,
-0.0334136,
-0.038640164,
0.009211493,
0.014964612,
0.030215256,
-0.0152896475,
-0.016550783,
0.008093372,
0.018566001,
-0.014080517,
0.011551744,
-0.032477498,
-0.004908029,
0.02143931,
-0.0007995861,
-0.022791456,
-0.6423732,
-0.014223533,
-0.0031772172,
-0.013306933,
-0.006747727,
0.0167068,
0.007599319,
-0.002488143,
0.009861562,
0.020958258,
-0.01159725,
-0.000605784,
0.006708723,
-0.021660333,
-0.014782593,
-0.016225748,
0.0025125206,
-0.02570377,
0.013755482,
-0.019372087,
-0.017096842,
0.0042384565,
-0.013872495,
0.004316465,
-0.00047170708,
0.0031219614,
0.006094407,
-0.013469451,
-0.013014402,
0.034089673,
-0.01280638,
0.019437093,
-0.024871679,
0.0076318225,
0.04844322,
0.009861562,
-0.0022719947,
0.027822997,
0.025027696,
0.011220209,
-0.010895174,
-0.018579002,
-0.0010254855,
0.0022427416,
-0.009335006,
0.04612897,
0.009087979,
-0.011662257,
-0.01809795,
0.017044837,
0.0053240736,
0.0050347922,
-0.044308774,
-0.001414715,
-0.0018754521,
0.0088669555,
0.024975691,
-0.004742261,
0.025547752,
0.012039297,
0.0060521523,
0.013976506,
-0.014821597,
-0.029019127,
-0.0030081992,
0.005905886,
-0.026483854,
0.019710124,
-0.006338183,
0.022765452,
0.016498778,
0.04576493,
-0.004491984,
0.007553814,
0.0031544648,
0.042176545,
0.0057011144,
0.01104469,
-0.027875002,
0.021829352,
0.019372087,
-0.024923686,
-0.016641794,
0.008080371,
0.020828243,
0.016264752,
-0.021010263,
0.03731402,
0.01401551,
-0.0011733765,
0.014223533,
0.0044399784,
-0.00807387,
-0.046389,
-0.013638469,
0.0010904925,
0.008665434,
0.00639994,
0.022700446,
-0.0020558464,
-0.016277755,
0.0031235865,
0.009517025,
-0.006224421,
0.008346899,
-0.008216885,
-0.024390629,
0.024260614,
0.042826615,
-0.02961719,
0.017863926,
-0.00031122103,
-0.008769445,
-0.007222278,
0.0009994827,
-0.026418846,
-0.0073262895,
-0.004856023,
0.002868434,
-0.0482612,
-0.0028456815,
-0.005551598,
-0.003286104,
-0.0140025085,
0.0049502836,
0.005392331,
0.0070662615,
-0.03655994,
-0.024923686,
-0.014717585,
0.0071572713,
-0.019619115,
0.017122844,
-0.0075928182,
0.010056583,
0.009152986,
0.020568216,
-0.0037801573,
-0.018188959,
-0.03416768,
0.00816488,
-0.022791456,
0.00873044,
-0.0108171655,
-0.019710124,
-0.014535566,
-0.014496562,
-0.0014642827,
-0.012884388,
-0.027042914,
0.018865032,
0.0016373639,
0.0060359,
0.0076968293,
0.035025775,
-0.019801134,
-0.008236388,
-0.02255743,
-0.00825589,
-0.000677698,
-0.016927823,
0.012091302,
-0.01039462,
-0.0011961289,
-0.012721871,
-0.01753889,
-0.014795594,
0.019099059,
-0.000036363293,
-0.04956134,
0.006646966,
-0.022921469,
-0.023025481,
0.014236534,
-0.011291716,
0.020178175,
-0.01215631,
0.0086069275,
-0.014548567,
-0.006627464,
0.0013228925,
-0.04449079,
0.005151805,
0.003370613,
0.018800026,
0.004648001,
0.04880726,
-0.00087596936,
0.011486738,
0.029175144,
-0.0050900485,
0.006578709,
-0.015601681,
0.013599466,
0.019905144,
-0.034843754,
0.006598211,
0.013001401,
0.008268891,
0.010960181,
0.021712339,
-0.012565854,
0.02293447,
-0.011532242,
0.00584738,
-0.010446626,
-0.010752158,
-0.00047902035,
0.014912607,
0.014236534,
0.0040401854,
0.023714555,
-0.011493239,
-0.012214816,
0.0072287787,
0.0016552409,
0.002328876,
-0.005327324,
-0.029643195,
-0.013625468,
0.0018852031,
-0.014886604,
0.015653687,
-0.0154456645,
-0.00008694687,
0.01030361,
0.004576493,
0.012390335,
-0.016966827,
-0.032217473,
-0.0031479641,
0.0014114645,
0.016303757,
-0.006607962,
0.0027237935,
-0.0020802242,
-0.003238974,
-0.020620221,
0.032191467,
0.0044172257,
-0.00028907802,
0.016420769,
0.0065917103,
0.0045699924,
0.004797517,
-0.0015463541,
0.024871679,
0.035129786,
0.0025596507,
0.0005610917,
-0.011077194,
0.0070142555,
-0.02264844,
-0.0076448238,
-0.0013196422,
-0.010167096,
0.012786877,
0.018357977,
0.07400397,
0.014067516,
0.0058311285,
-0.007898351,
-0.009367509,
-0.015107628,
0.020672228,
0.008840953,
0.015263645,
-0.014912607,
-0.020451203,
0.023792563,
0.0018624506,
-0.0012091303,
0.0042742104,
-0.013313434,
0.008515918,
0.018982045,
0.0012465093,
-0.0016251751,
0.016628793,
0.02774499,
-0.008905959,
-0.018878033,
0.022245396,
0.02627583,
0.006078155,
0.0072807847,
-0.028369056,
0.02432562,
-0.018592004,
0.0140025085,
0.017499885,
0.0035331307,
-0.00040385601,
-0.009640539,
-0.0060651535,
-0.004316465,
0.021738343,
-0.007820343,
0.023077486,
-0.018618006,
0.028005017,
-0.018579002,
-0.013521457,
-0.017980937,
0.039004203,
0.004118194,
-0.003045578,
-0.00038232244,
-0.0071117664,
-0.033179574,
-0.018774023,
-0.0061106584,
0.008593926,
-0.01383349,
0.0068647396,
0.016238749,
-0.01058314,
0.012305826,
0.026990907,
-0.005151805,
0.018605005,
-0.03453172,
0.018448988,
-0.005337075,
0.03572785,
0.011701261,
-0.010427124,
0.025196714,
-0.0067932317,
0.017616898,
-0.0002027406,
-0.0012205065,
0.02561276,
-0.026145818,
0.012747874,
-0.014119522,
0.0023240005,
-0.008743442,
0.012552853,
0.035129786,
-0.010726156,
-0.0232075,
-0.015172634,
-0.017187852,
0.026366841,
-0.027692983,
0.026483854,
0.015575678,
0.03518179,
-0.014340545,
-0.0013797736,
0.019346084,
0.009243996,
-0.01040112,
0.0016999332,
0.026938902,
0.006273176,
0.02219339,
-0.025755774,
-0.017993938,
0.0052525657,
0.00069476233,
0.0038126607,
0.008749942,
0.011525742,
0.016771806,
0.01708384,
0.0011611877,
-0.0006139099,
-0.007774838,
-0.008665434,
-0.0019274576,
-0.012851885,
0.003024451,
0.0152376415,
-0.017434878,
0.0055093435,
-0.019528104,
0.0057953745,
0.0051453044,
0.010804164,
0.00053265115,
-0.005129053,
-0.030865325,
-0.008398904,
-0.022726448,
-0.0042839614,
-0.024494639,
0.01058314,
-0.020490207,
-0.020217178,
0.0047357604,
-0.01030361,
-0.018383982,
0.009920069,
-0.020776238,
-0.0061139087,
0.011987291,
0.018032944,
-0.0054898416,
0.019385088,
-0.0068192347,
0.010908175,
0.044152755,
-0.013020903,
-0.026522858,
-0.001995715,
-0.05114751,
-0.0040986915,
-0.0051128007,
-0.0071507706,
-0.032243475,
-0.010804164,
0.010427124,
0.00088165747,
-0.0059253885,
0.0026977907,
0.0050802976,
-0.013261429,
0.018800026,
0.005707615,
0.02774499,
-0.008281892,
-0.04100642,
-0.0045114863,
-0.025469745,
-0.0011863778,
-0.014041513,
-0.0043002134,
-0.0064389436,
-0.005129053,
0.0055190944,
-0.006832236,
0.003666395,
-0.00082802674,
-0.018487992,
-0.010498631,
0.006663218,
-0.014964612,
0.013443449,
-0.0010766785,
0.014652579,
-0.014392551,
0.015939718,
-0.017382873,
-0.030423278,
0.0139245,
-0.0005139616,
-0.003776907,
0.0007041071,
0.010349115,
0.0040596873,
-0.0040986915,
-0.009276499,
-0.020776238,
0.03962827,
-0.012019795,
-0.029929224,
-0.009946072,
-0.018370979,
0.016290756,
-0.004791016,
-0.006832236,
-0.017512888,
-0.005606854,
0.029149141,
-0.0012773876,
-0.0072872853,
0.015276646,
-0.044048745,
-0.0061561633,
0.020061161,
-0.0017941933,
0.022726448,
-0.013937501,
-0.00519731,
-0.029669197,
-0.005834379,
-0.03193144,
-0.02478067,
-0.012559353,
-0.012565854,
0.042306557,
0.04072039,
0.021465313,
-0.015042621,
0.008346899,
-0.0003890263,
0.017473882,
0.008320897,
0.010609143,
0.0059253885,
-0.010219101,
0.015939718,
0.026964905,
-0.01235133,
0.0026701626,
-0.03427169,
0.0023337514,
0.005129053,
-0.0037184006,
-0.0141585255,
0.0066307145,
-0.031125354,
-0.03203545,
0.024065593,
-0.022804458,
-0.004791016,
-0.026834892,
0.001790943,
-0.00059197005,
0.03603988,
0.009380511,
-0.006338183,
0.029591188,
-0.008054368,
-0.0001889266,
-0.019684121,
0.011467235,
-0.006227671,
-0.0051550553,
-0.000120161385,
-0.030657303,
0.004157198,
0.018318973,
-0.0015040996,
0.022570431,
-0.013482452,
-0.012299325,
-0.009627537,
-0.023532536,
-0.018618006,
-0.00845091,
-0.01911206,
-0.02024318,
-0.012838883,
-0.019073054,
-0.03871817,
-0.0065137018,
0.008801948,
-0.014977613,
0.01903405,
-0.017005833,
0.016368764,
0.03427169,
-0.01643377,
0.0054800906,
-0.037652057,
0.019346084,
0.02933116,
-0.04056437,
-0.009562531,
-0.01688882,
0.0073652933,
0.0049437825,
0.043788716,
0.011649255,
-0.0038744174,
0.0028668088,
0.0026604116,
-0.013768484,
0.00696225,
-0.037990093,
0.0152896475,
0.008847454,
-0.0069947536,
-0.022232395,
-0.009627537,
-0.037288018,
0.019749127,
-0.011753267,
-0.007839845,
0.005551598,
-0.013495454,
-0.003182093,
0.00097104214,
0.005207061,
0.01652478,
0.0026441598,
-0.020139169,
-0.011467235,
-0.013040405,
0.0106611485,
0.0018413233,
-0.006741226,
0.005636107,
-0.009361008,
-0.0055645998,
0.016446771,
0.018865032,
0.02264844,
-0.0102776075,
-0.0022866214,
0.04464681,
-0.014600573,
-0.0014163401,
0.037366025,
0.0011733765,
-0.01159725,
0.00043960987,
0.006256924,
-0.012149809,
-0.025508748,
-0.024559647,
0.021322297,
0.037184007,
-0.009868063,
-0.010550637,
-0.0040791896,
-0.0072872853,
-0.014145524,
-0.012221317,
0.005707615,
-0.018370979,
-0.017278861,
-0.0033966159,
0.014600573,
0.043034635,
-0.001461845,
0.007046759,
-0.025755774,
0.024104597,
-0.02004816,
0.015172634,
0.0024816424,
-0.010089087,
-0.0017275611,
0.007183274,
-0.025027696,
-0.03564984,
-0.004612247,
-0.012689367,
-0.037262015,
-0.01865701,
-0.020074163,
0.0003522567,
0.026379842,
-0.02552175,
0.030111244,
-0.0021029767,
0.02459865,
-0.012221317,
-0.017057838,
0.0087109385,
-0.009497523,
0.0070207566,
0.015705692,
-0.02894112,
-0.025053699,
0.011395728,
-0.01531565,
-0.0061854166,
-0.014652579,
-0.008184382,
-0.03692398,
0.022284402,
0.0055548484,
0.0048430217,
0.01058314,
-0.014548567,
-0.024195608,
0.023519535,
0.010882173,
-0.013586463,
-0.008359901,
-0.0008426533,
0.004118194,
0.018370979,
-0.029409168,
0.010791163,
-0.01326793,
-0.035389815,
-0.030839322,
0.0070662615,
-0.013482452,
0.036429927,
0.012273323,
-0.017226856,
-0.015614683,
-0.00015175072,
-0.055698,
-0.040304344,
0.027198931,
0.005532096,
0.0016755555,
0.020555215,
0.0062439227,
0.017213855,
-0.01012159,
0.0020249682,
-0.007846345,
-0.031229366,
0.019710124,
-0.025456743,
0.021452311,
0.0126438625,
-0.030865325,
0.0012773876,
0.035233796,
0.00055337214,
-0.03583186,
0.021933364,
0.014652579,
0.013196422,
-0.0010376743,
-0.0053435755,
-0.008801948,
0.030215256,
0.02904513,
-0.0046512512,
0.01401551,
0.0085549215,
-0.023311513,
0.0010904925,
0.0071962755,
0.015471667,
0.0039784284,
0.017148847,
0.017148847,
-0.0140545145,
0.0050997995,
-0.017278861,
0.0142105315,
0.018318973,
-0.0028359306,
0.02088025,
0.015068623,
-0.013157418,
-0.011252712,
-0.0046284986,
0.0048787757,
-0.022726448,
0.0025840285,
0.00017795667,
-0.011772769,
-0.0036208902,
-0.014496562,
-0.019801134,
0.002293122,
0.007553814,
0.0009661666,
0.010966682,
-0.011662257,
0.018500993,
-0.005327324,
-0.025209716,
-0.008177881,
-0.031957444,
-0.0129949,
0.0029350661,
0.0064096907,
0.001174189,
0.006481198,
-0.0054995925,
-0.0055645998,
0.008203884,
0.01746088,
-0.0041799503,
-0.018891035,
-0.0014488436,
0.18992446,
-0.020581217,
-0.010557137,
0.021972368,
0.01605673,
0.004530988,
0.0055353465,
0.0009328505,
-0.013443449,
0.007898351,
0.037236013,
0.035025775,
-0.0070207566,
-0.0063804374,
0.013092411,
-0.02422161,
-0.026613867,
-0.0021468564,
-0.014093518,
0.0055711004,
-0.019749127,
0.00287656,
0.019541105,
-0.010011079,
0.016160741,
-0.007878849,
-0.004862524,
0.012520349,
0.010050083,
0.0032552257,
-0.0049502836,
0.021517318,
0.010245103,
0.0026295334,
0.017772915,
0.01726586,
0.003656644,
-0.009829059,
-0.0031772172,
-0.019151064,
-0.00019796664,
0.011954788,
-0.008827951,
0.0071702725,
0.032165464,
0.0075213104,
-0.02060722,
-0.010823666,
-0.01595272,
-0.0044692317,
-0.03869217,
-0.005902636,
0.012000293,
0.035207793,
-0.013339438,
0.0065364544,
0.019255074,
0.020568216,
0.0102061,
0.0075668152,
-0.018865032,
-0.0036533936,
-0.021101274,
0.040252335,
-0.02987722,
0.02571677,
-0.020763237,
0.0019420843,
0.021491315,
-0.012689367,
-0.0012123806,
0.0048950273,
-0.0051095504,
-0.005233064,
0.004407475,
-0.0082753915,
0.047585126,
0.00816488,
0.0076773274,
0.027588973,
-0.0010368617,
-0.012851885,
-0.031437386,
-0.0012326953,
-0.01614774,
-0.021101274,
0.010836667,
-0.0003085801,
-0.029227149,
0.0056556095,
0.015211639,
-0.0087629445,
-0.014587572,
0.009113982,
0.021465313,
-0.00066307146,
-0.004930781,
0.003136588,
-0.026613867,
-0.015042621,
-0.039108213,
0.07785239,
-0.0061659142,
0.009920069,
-0.0016552409,
0.008931963,
-0.01986614,
0.021023266,
0.00863293,
0.003916672,
0.0072612823,
-0.03239949,
0.009985076,
-0.022973476,
-0.0108691715,
0.045530904,
0.01354746,
-0.030085241,
0.064538956,
-0.020334192,
0.0035721348,
-0.011668758,
0.0060846554,
0.033647627,
0.013573462,
0.019697122,
-0.012266821,
-0.0005456525,
0.005161556,
-0.0085549215,
-0.018552998,
0.012656864,
-0.02904513,
-0.017330868,
0.0023808815,
-0.004235206,
0.024572648,
-0.0026311586,
-0.011467235,
0.023337515,
-0.007339291,
-0.0012107554,
0.0057563703,
0.021751344,
-0.00882145,
-0.0070662615,
0.014964612,
0.019463098,
-0.010219101,
-0.025404736,
-0.008288393,
-0.0151336305,
-0.010030581,
-0.012338329,
0.024299618,
-0.015107628,
-0.0004639875,
-0.0118962815,
-0.0008036491,
0.013417446,
-0.044802826,
0.0032552257,
0.025963798,
-0.015627684,
0.00046114344,
0.01977513,
-0.1615294,
0.031333376,
0.02375356,
-0.027953012,
0.035597835,
-0.008619929,
-0.00028603082,
0.000598877,
-0.02273945,
-0.003128462,
0.028733095,
-0.013209423,
-0.025183713,
-0.018383982,
0.012110805,
0.020113166,
0.012903891,
0.013124914,
0.006143162,
0.009217993,
0.009419515,
-0.008203884,
-0.0057791225,
-0.014132523,
0.023506533,
0.015848707,
0.016290756,
-0.0055255955,
0.005356577,
0.0017405625,
0.00334136,
-0.006988253,
0.044152755,
-0.002340252,
0.035103783,
0.021309296,
0.0004883651,
0.024910685,
-0.008944964,
0.008177881,
0.017707909,
0.024949688,
-0.015068623,
0.018800026,
-0.022245396,
0.013690475,
-0.0074758055,
-0.02766698,
0.009354508,
-0.0046252483,
0.020555215,
-0.006572208,
-0.004010932,
0.027068917,
0.032607514,
0.012780377,
0.0006009085,
0.023597542,
-0.004056437,
-0.015991723,
-0.025274724,
-0.0114087295,
0.0028798103,
-0.0025303976,
-0.00482677,
-0.023103489,
-0.0072872853,
0.0018998297,
-0.019619115,
0.013007902,
-0.041916516,
-0.0061139087,
0.0021939864,
-0.0024637654,
0.01652478,
0.016485777,
-0.003516879,
-0.0074172993,
0.0032974803,
0.009718547,
-0.017005833,
-0.002598655,
-0.0074498025,
-0.0154456645,
0.010648147,
-0.011090195,
0.006143162,
0.00807387,
0.006013148,
0.01493861,
0.02154332,
-0.027822997,
0.026678875,
-0.013989507,
0.028525073,
0.022466421,
0.018253967,
0.009679543,
-0.030345269,
-0.0074498025,
0.013690475,
-0.011928786,
-0.012292825,
0.0014374674,
-0.001735687,
0.0016446772,
-0.000116403164,
0.002887936,
0.06615113,
-0.012058799,
-0.022583432,
-0.017369872,
0.011480237,
0.034089673,
-0.012884388,
0.043684706,
0.0011246211,
-0.009491023,
-0.011935286,
-0.022258399,
0.058610316,
0.006598211,
0.0007955232,
0.02375356,
0.022297403,
-0.024065593,
-0.14415953,
-0.016108736,
0.0013513331,
0.008879957,
0.0024150102,
0.035207793,
-0.012260321,
0.027406953,
-0.028291048,
0.020958258,
-0.026938902,
-0.009588533,
-0.004553741,
-0.029461173,
0.0073652933,
-0.014457557,
0.007527811,
-0.011818273,
-0.028291048,
0.025482746,
0.00090847287,
-0.008593926,
-0.010882173,
0.002822929,
0.021452311,
0.013404444,
-0.0131834205,
0.013007902,
0.017252859,
0.0015926716,
0.018826028,
0.0002244773,
0.019658118,
-0.013306933,
-0.0040304344,
-0.0044399784,
0.018552998,
-0.018800026,
0.010076086,
-0.020269183,
0.0006070029,
0.00068460504,
0.017616898,
0.010875672,
0.013612467,
-0.019086055,
-0.03564984,
0.004186451,
-0.0019274576,
-0.0057498696,
-0.027849,
0.00074189244,
-0.035623837,
-0.008236388,
0.00845091,
-0.019567108,
-0.0045699924,
0.012266821,
-0.00075936306,
-0.010362117,
-0.010459627,
0.004501735,
-0.014977613,
0.017928932,
0.020100165,
-0.025729772,
-0.013638469,
-0.032477498,
0.018357977,
-0.021972368,
-0.0023435026,
-0.00016444741,
-0.010888673,
-0.023506533,
-0.028109029,
-0.0016593038,
-0.013196422,
-0.024819674,
0.002293122,
-0.0070987646,
-0.016589787,
-0.028473068,
0.017486883,
-0.021010263,
0.030319266,
0.021127276,
-0.003386865,
0.0028148033,
0.010622145,
-0.011935286,
0.00380616,
0.025755774,
-0.00052005606,
-0.02255743,
0.0044139754,
0.0125398515,
-0.024650656,
-0.017239857,
0.03255551,
0.008223386,
-0.010836667,
-0.0120718,
-0.035155788,
0.02060722,
-0.0010555512,
0.010414122,
0.015341653,
-0.030475283,
0.0044627306,
-0.022349408,
0.017200854,
0.029253151,
-0.018722016,
0.0068257353,
0.0025076452,
-0.0031154607,
-0.03681997,
-0.018956043,
0.023051484,
-0.005281819,
0.009107482,
0.029591188,
0.0031382132,
-0.023480529,
-0.00761232,
0.016745804,
-0.009595034,
0.0024995194,
-0.009120483,
0.033621624,
-0.015341653,
-0.025287725,
-0.00018141017,
-0.021010263,
0.004371721,
-0.00029781333,
-0.008496416,
-0.021556323,
0.0018478241,
0.03070931,
0.005912387,
0.0427226,
-0.012169311,
-0.030059239,
-0.0012489471,
-0.0059448904,
0.0022898717,
0.008099873,
-0.040122323,
0.0021387304,
-0.009022973,
-0.03351761,
0.048937272,
0.019268077,
-0.0063089295,
-0.027692983,
-0.025482746,
0.0039849295,
0.013755482,
-0.0033478606,
-0.01159725,
-0.016849816,
0.0140545145,
0.012260321,
-0.016680798,
0.019528104,
0.017304864,
-0.016693799,
-0.03125537,
0.022427415,
0.027796995,
0.0020379697,
-0.01160375,
-0.0056166053,
0.00733279,
-0.01661579,
-0.009296002,
-0.0017893178,
-0.01977513,
0.012286324,
0.0009937945,
0.011220209,
-0.0009523526,
0.016745804,
-0.006624214,
0.0040434357,
0.002523897,
-0.0066892207,
-0.0038126607,
0.005577601,
0.0020200927,
-0.021634331,
-0.0016284254,
0.022414414,
0.011636253,
0.009478021,
0.006507201,
0.0024540145,
-0.009725048,
-0.0008824701,
-0.00723528,
0.017655902,
-0.0009157862,
0.01874802,
-0.0011693134,
-0.021595327,
-0.026496856,
0.008151879,
-0.045348886,
-0.018670011,
-0.0072417804,
0.01643377,
-0.00049202173,
-0.0015991722,
0.022024373,
-0.02116628,
-0.040174328,
0.026418846,
0.0043457183,
-0.009621036,
-0.008054368,
0.040304344,
0.0102126,
-0.0016674297,
-0.00033397347,
-0.00082762045,
0.015614683,
0.0062699257,
0.016290756,
-0.010427124,
0.041812506,
-0.0013716478,
0.0066892207,
-0.011675258,
-0.014262537,
0.0066534667,
-0.0001594703,
-0.014678582,
-0.0076513244,
0.015731694,
0.012695868,
0.056010034,
0.008281892,
-0.0058636316,
0.0045472397,
-0.010732656,
0.036871973,
0.011714262,
0.026015803,
-0.0176299,
-0.01707084,
0.022037374,
0.005031542,
0.033179574,
-0.0241306,
-0.010258106,
0.023909576,
-0.008320897,
0.032347485,
-0.0012651988,
0.0028326802,
0.010147593,
-0.0058993855,
0.007202776,
0.004293713,
-0.04100642,
0.009614536,
0.032165464,
-0.0016853065,
-0.0053825798,
-0.018188959,
-0.0060359,
0.009159487,
-0.019177066,
-0.0062309215,
0.0073457914,
0.016082732,
-0.015796702,
-0.013352439,
0.0065657073,
0.0033169824,
-0.003776907,
0.03081332,
-0.016849816,
-0.03554583,
-0.015055622,
-0.014236534,
-0.015978722,
-0.0213613,
-0.020178175
] |
Abstract Hyperhomocysteinemia has been suggested as a possible risk factor in women suffering from habitual abortions, placental abruption or infarcts, preeclampsia, and/or intrauterine growth retardation. However, little is known about the pathogenic mechanisms underlying the action of homocysteine. The present study investigated the in vitro ability of homocysteine to affect trophoblast gonadotropin secretion and to induce cell death. In primary human trophoblast cells, homocysteine treatment (20 μmol/L) resulted in cellular flattening and enlargement, extension | [
-0.032274537,
-0.019571006,
0.017730106,
-0.03397182,
-0.027652698,
0.017521208,
-0.017717049,
-0.002173831,
-0.018826813,
-0.0047360794,
0.009145757,
0.004044109,
0.012670889,
0.008160026,
0.0005267297,
0.0138655165,
0.04875126,
0.0012949961,
0.004680591,
0.0010232673,
0.0016564854,
0.015236401,
-0.007879321,
0.010914851,
0.0006491301,
0.000626282,
0.02275668,
-0.050030753,
-0.00844726,
-0.018644027,
-0.0027482968,
-0.0067434455,
-0.0027450328,
-0.008819357,
-0.0112086125,
-0.015510578,
0.0042791176,
0.0059959874,
0.007833625,
0.008930333,
-0.000034374112,
0.026307926,
0.0034663791,
0.006449685,
0.0007992746,
0.0105362255,
-0.0061852997,
0.0040082047,
-0.023331147,
0.024140622,
0.024793424,
0.015027504,
-0.011685157,
0.03995149,
-0.00070625026,
0.011600293,
-0.0032264744,
0.017521208,
0.00804905,
-0.010092321,
0.0083166985,
-0.010033568,
-0.03747084,
0.04183156,
0.0025736722,
0.023161419,
0.008832413,
0.004527183,
-0.0063321805,
0.014413871,
0.0093415985,
0.029741663,
-0.008205722,
-0.017390648,
0.0041224454,
-0.028984413,
-0.049064606,
-0.014766384,
0.018879037,
0.008173082,
0.029297758,
0.005904595,
-0.01698591,
0.028148826,
0.016646454,
-0.00026642485,
-0.03331902,
0.009805088,
0.021725254,
-0.005532498,
0.0042627975,
0.02424507,
0.014413871,
0.025981523,
-0.00066177815,
0.01289937,
0.0024463758,
0.047785114,
-0.00008287527,
-0.00078336254,
-0.015366961,
-0.008688796,
-0.0052093607,
-0.008747548,
-0.018683197,
-0.0036165237,
-0.009674527,
0.0057218103,
0.0035022832,
-0.014622767,
-0.024101453,
0.0339196,
0.0018066298,
-0.027078232,
-0.007833625,
-0.008434203,
0.022913354,
0.019688511,
-0.018147899,
0.0035381874,
-0.00096777914,
0.0014394287,
0.027600473,
-0.019205438,
0.008381979,
0.011717798,
-0.024023117,
-0.011273893,
-0.004974352,
0.0016809654,
0.006518229,
0.02968944,
0.018095674,
-0.01929683,
-0.024950096,
0.023291979,
-0.021555526,
-0.02372283,
-0.017795386,
-0.03822809,
0.016411444,
0.024205903,
-0.02368366,
0.0042334218,
-0.011189028,
0.009948704,
0.022821961,
0.023109194,
0.01665951,
0.0067173336,
0.0078075132,
-0.016111156,
0.021555526,
-0.04175322,
-0.0015895731,
0.0051473444,
-0.0059796674,
0.017978169,
-0.031047268,
-0.016176436,
-0.00041310134,
0.0026258964,
0.002168935,
0.0076182005,
0.011371813,
0.020341314,
-0.003131818,
-0.0022733833,
0.00808169,
-0.016829237,
-0.009387294,
0.011802662,
-0.005369297,
-0.006622677,
-0.009426462,
0.010020512,
-0.011737382,
0.031230053,
-0.012044199,
-0.033736814,
-0.03519909,
0.036243573,
0.031230053,
0.014492206,
-0.015288625,
0.014257198,
0.02517205,
-0.027234904,
0.015145008,
-0.008094746,
-0.009622303,
0.014753328,
-0.0013015242,
0.0023843597,
-0.6396416,
-0.0052354727,
-0.004958032,
0.0011783078,
-0.0004708335,
0.022900298,
0.001246852,
0.00056304183,
-0.022952521,
-0.0011889158,
-0.016437557,
0.049169056,
-0.007507224,
-0.009602719,
0.016176436,
-0.025550675,
-0.021921095,
-0.015484466,
0.004958032,
-0.010353441,
-0.002738505,
0.0048894878,
-0.010327329,
0.0107712345,
0.025681235,
0.046636183,
0.020524098,
-0.0033586668,
-0.013180074,
0.022143047,
0.008714908,
0.018983485,
-0.024153678,
0.013774124,
0.052433066,
0.00019747263,
0.0059959874,
0.032901227,
-0.0033260267,
0.037157495,
0.014936112,
-0.006514965,
0.02417979,
-0.0048535834,
-0.013042986,
0.02061549,
0.016620342,
-0.0054182573,
0.0006780982,
0.0072330474,
-0.0019600382,
0.0057413946,
-0.0021183428,
0.0009685951,
-0.001246852,
0.013356331,
0.027652698,
-0.020106304,
0.0029718815,
0.008656156,
-0.0103338575,
0.026973782,
-0.01391774,
-0.01534085,
-0.009419934,
0.026177363,
-0.02342254,
0.0048437915,
-0.016411444,
0.012344488,
0.007742233,
0.024858704,
-0.010281633,
0.0057479227,
0.025054544,
0.04473,
0.004938448,
0.014061357,
-0.013539116,
0.008897693,
-0.0067238617,
-0.006296276,
-0.008662684,
0.00917187,
0.0274438,
0.0011130276,
-0.012448936,
0.014688048,
0.003410891,
-0.009439519,
0.00057446584,
-0.0054443697,
-0.00038331724,
-0.016711734,
-0.009073949,
0.017991226,
0.004683855,
0.011110691,
0.012879785,
-0.0015047089,
-0.03532965,
-0.025054544,
-0.0024447439,
0.024349518,
-0.00051244965,
0.0048503196,
-0.036374133,
-0.011097636,
0.039873153,
0.003430475,
0.021646917,
0.0070763747,
0.013134378,
-0.02595541,
0.006834838,
-0.026229588,
-0.016202549,
0.0016369013,
-0.0108887395,
-0.041648775,
0.009282846,
0.0103338575,
-0.009191453,
0.0030469538,
-0.013447723,
0.000029376095,
0.019884352,
-0.0073309676,
-0.006616149,
-0.019845184,
0.019962689,
-0.0061036996,
0.028201051,
-0.015850035,
0.03209175,
-0.007885849,
0.037157495,
-0.0022831752,
0.004582671,
-0.011267364,
-0.025407057,
-0.0022456392,
0.003091018,
0.006495381,
-0.020041024,
-0.010784291,
-0.017625656,
-0.003148138,
0.00001552955,
0.0039592446,
-0.0058099385,
-0.0069849826,
-0.013421611,
0.041570436,
-0.00032436106,
-0.012155175,
-0.021398854,
-0.018526524,
0.006867478,
-0.0023353996,
0.010758178,
0.03632191,
-0.0041975174,
0.0025850963,
-0.012664361,
-0.0027270808,
-0.0060775876,
-0.03107338,
-0.0018049978,
-0.022900298,
-0.0026764886,
-0.028958302,
-0.0054084654,
0.006247316,
-0.014896944,
0.013421611,
0.0018262139,
0.00029274094,
-0.038410876,
0.017338423,
-0.0010820195,
-0.032796778,
-0.013761069,
0.00076377846,
0.020080192,
0.00804905,
0.019205438,
0.0025573522,
0.01421803,
0.040160384,
-0.00676303,
0.02869718,
-0.027992154,
0.006482325,
0.0023288715,
-0.015680306,
-0.00040922532,
-0.00029784095,
-0.010124961,
0.04224935,
0.02391867,
-0.0057609784,
0.0075920885,
-0.0026699605,
0.032143977,
-0.007866265,
-0.016111156,
-0.0016303733,
0.009870368,
-0.015158065,
-0.008362395,
0.012821034,
-0.012266152,
-0.0021917832,
-0.004700175,
-0.022195272,
-0.007154711,
-0.023396427,
0.0136305075,
-0.00090494694,
0.016972855,
-0.009726752,
0.021163844,
0.0034990192,
-0.011025827,
0.0000037516995,
-0.00037842122,
-0.009622303,
0.0049972,
-0.00808169,
-0.004390094,
0.0072917994,
-0.004004941,
-0.014309422,
0.022704458,
0.010758178,
0.003401099,
-0.016085044,
0.02692156,
0.018448187,
-0.013473836,
-0.009720223,
0.009583135,
-0.0029767775,
0.00023154075,
-0.0108887395,
0.023696717,
0.0051669287,
-0.002177095,
0.024702031,
-0.0012191079,
0.02249556,
-0.004902544,
-0.022808906,
-0.009047837,
0.02893219,
-0.022678345,
0.008068634,
0.0352252,
0.023526987,
0.022286663,
-0.014661935,
0.00025704084,
-0.0067042774,
-0.02068077,
0.017560376,
0.012448936,
0.017599545,
-0.012005031,
0.011012771,
-0.023043914,
-0.015131953,
-0.0038645884,
-0.009393822,
0.014674991,
0.008767133,
0.017181752,
0.038698107,
0.011123748,
0.0063354443,
-0.016111156,
-0.02180359,
0.024362575,
0.031151716,
-0.022456393,
0.0112412525,
-0.013121322,
-0.007794457,
0.010940963,
0.029741663,
0.016763957,
-0.000927795,
0.022077767,
-0.0010518273,
-0.010386081,
-0.02869718,
-0.009191453,
-0.021960262,
0.034363504,
-0.0027009686,
-0.001884966,
-0.023344204,
-0.022639178,
0.0073701357,
0.032875113,
0.016711734,
-0.005016784,
-0.0025769363,
0.0013619084,
-0.023213644,
0.0068152538,
-0.0042366856,
-0.009406879,
0.007193879,
-0.013878573,
0.013473836,
-0.003675276,
-0.0057707704,
0.013682732,
-0.004328078,
-0.004070221,
-0.028148826,
-0.011515429,
-0.01547141,
0.017508153,
0.03342347,
-0.007794457,
0.013473836,
0.030864483,
0.027339352,
0.0017087095,
-0.03786252,
0.014231086,
-0.021124676,
0.012697001,
-0.014831664,
-0.00091310695,
-0.0016279252,
0.00926979,
0.012775337,
-0.007696537,
-0.010059681,
-0.0036393718,
0.005911123,
0.011991975,
-0.016737847,
0.0073636076,
0.02869718,
0.020171585,
-0.0026993367,
0.008812828,
0.011300004,
-0.0005503938,
0.0047262874,
-0.01748204,
0.017912889,
-0.012194343,
0.0033619308,
-0.0044912784,
-0.033736814,
-0.018147899,
-0.012063783,
0.004628367,
0.0053921454,
0.008943389,
0.017064247,
0.005189777,
0.0038058362,
-0.00686095,
-0.013016874,
0.025106769,
-0.013617452,
-0.00949827,
-0.030133344,
0.029715551,
-0.012233512,
0.0057772985,
-0.016646454,
0.0028625373,
-0.02757436,
-0.0063321805,
-0.0021836231,
0.0030469538,
0.014701104,
-0.002485544,
-0.023331147,
0.018108731,
-0.014022189,
0.016555062,
0.005245265,
-0.02731324,
-0.00956355,
-0.021490246,
0.008127386,
0.033475693,
-0.025877075,
-0.040891524,
-0.00043860142,
0.0069327583,
0.015967539,
0.010124961,
-0.008851997,
-0.008009882,
0.011554597,
-0.03707916,
-0.014557487,
-0.017273143,
-0.023148363,
-0.010640674,
-0.027966043,
-0.0003998413,
-0.018630972,
-0.023004746,
-0.0015814131,
0.015001392,
-0.025276497,
-0.01553669,
-0.027261015,
-0.012507688,
0.0014728848,
0.0047980957,
0.029767776,
-0.008832413,
0.012142119,
0.012599081,
-0.03572133,
-0.011319589,
-0.03744473,
-0.0011619878,
-0.009478686,
-0.018787645,
-0.007376664,
0.006172244,
0.0032493225,
0.014570543,
0.007135127,
-0.002823369,
-0.010190241,
0.01553669,
0.03472907,
-0.012129063,
0.029376095,
-0.009380766,
0.0016434293,
0.007409304,
-0.013134378,
0.04068263,
-0.018826813,
-0.012396712,
0.0072004073,
0.032248423,
-0.040787075,
-0.021764422,
0.0015381649,
0.0047915676,
0.034363504,
-0.0048274714,
-0.018160954,
-0.032875113,
-0.016881462,
-0.018030394,
0.00088536285,
-0.0023141834,
-0.022456393,
-0.0019306622,
0.008303642,
-0.031804517,
-0.012481576,
0.019871296,
-0.035982452,
-0.0066389972,
-0.0054182573,
-0.01735148,
-0.0023370315,
0.0072852713,
0.002510024,
-0.028540509,
0.0028315291,
-0.031412836,
-0.035773557,
-0.007983769,
-0.0031008099,
0.023448652,
0.019205438,
0.038384765,
-0.0010428514,
0.03822809,
0.014570543,
0.02556373,
0.0050069923,
0.0050233123,
0.008923804,
-0.026033748,
0.034650736,
-0.004037581,
-0.015771698,
0.027600473,
-0.0047426075,
0.014583599,
0.056976568,
-0.02378811,
-0.008414619,
0.0054704817,
-0.03718361,
-0.024467023,
0.0020595905,
-0.012455464,
-0.0007923386,
-0.055984307,
-0.022338888,
0.008042522,
0.0026764886,
0.012220455,
-0.013552171,
0.016006708,
-0.02378811,
0.016241716,
-0.016202549,
-0.0038907006,
-0.006155924,
-0.0053986735,
0.032013416,
-0.00371118,
0.018095674,
-0.0033129707,
0.0053007533,
-0.0069392864,
-0.027417688,
-0.014361646,
0.014270254,
-0.008375451,
0.016346164,
0.009002141,
-0.004716495,
-0.022338888,
0.000609962,
0.004099597,
-0.023513932,
-0.003420683,
0.022338888,
-0.009322014,
-0.005157137,
-0.004749135,
-0.0047850395,
0.0017070775,
-0.005917651,
0.02582485,
-0.020994116,
0.020693827,
0.014805552,
-0.010686371,
-0.01722092,
0.0030143138,
0.013447723,
0.018252347,
0.037366394,
0.023761997,
-0.014688048,
-0.015105841,
0.0059307073,
0.0274438,
-0.012279208,
-0.030002784,
0.027652698,
0.00992912,
-0.005924179,
0.0042464775,
-0.009374239,
-0.005264849,
0.024741199,
-0.009289374,
-0.013434667,
-0.002141191,
-0.01702508,
-0.0049155997,
0.015092785,
0.004723023,
0.025041489,
0.009850783,
0.0027319768,
-0.020928835,
-0.039037567,
-0.010222881,
0.010843043,
-0.017860666,
0.030133344,
-0.016045876,
0.0061526597,
-0.0137480125,
-0.016946742,
-0.0020155264,
-0.00742236,
-0.014048302,
0.03807142,
-0.0128732575,
-0.00804905,
0.016398389,
0.011058467,
-0.0092240935,
-0.010379554,
-0.008603931,
-0.030107234,
-0.022874186,
-0.015445298,
0.021033283,
0.010895267,
-0.013330219,
0.0028462172,
-0.017834553,
0.0041844617,
-0.032065637,
-0.00989648,
0.024166733,
-0.027261015,
-0.017377593,
-0.0013423243,
0.0013929164,
0.013101738,
-0.02091578,
-0.023513932,
-0.006847894,
0.03420683,
-0.011371813,
0.013082154,
0.015771698,
0.018134842,
-0.011900582,
-0.02180359,
-0.007246103,
-0.0028478492,
-0.012945065,
-0.012592552,
-0.040264834,
-0.017690936,
-0.011848358,
0.0160981,
0.011495845,
-0.009504799,
0.045539476,
0.017834553,
0.016542004,
0.00936771,
-0.023096139,
0.0076443125,
-0.014035245,
0.012213928,
0.004938448,
-0.013578284,
-0.017638713,
-0.0060939076,
-0.018252347,
-0.0029947297,
-0.0029914656,
0.028357724,
0.008192667,
0.002157511,
-0.0012680681,
0.0033488749,
-0.006518229,
-0.02444091,
-0.026294868,
0.0050788005,
-0.004918864,
-0.0018719101,
-0.039925378,
0.014009133,
-0.009054366,
0.012220455,
0.0014639087,
0.012416296,
0.006560661,
-0.008016409,
-0.019283773,
0.007441944,
-0.009080477,
0.038384765,
0.008819357,
-0.020276032,
-0.008297115,
0.019322943,
-0.033736814,
-0.015366961,
-0.01058845,
-0.008127386,
0.004076749,
0.010222881,
0.0007437864,
0.0054378416,
-0.010288161,
0.007990298,
-0.014805552,
-0.003946189,
0.007063319,
0.006802198,
0.039742593,
0.0057413946,
-0.014544431,
-0.004993936,
0.014231086,
0.0056369463,
-0.022782793,
0.009393822,
0.01827846,
0.01722092,
-0.0052028326,
0.02048493,
0.010758178,
-0.0003702612,
-0.01722092,
-0.018395964,
0.004755663,
-0.014191918,
0.021281349,
-0.0154975215,
-0.0081143305,
0.0029784096,
-0.0073636076,
-0.015301681,
-0.023122251,
-0.036661368,
0.029950561,
-0.016489781,
0.0064398926,
0.02275668,
-0.027600473,
-0.004641423,
0.016293941,
0.0073897196,
-0.007024151,
0.012945065,
0.009622303,
0.019479616,
0.0006931942,
-0.006531285,
-0.030864483,
-0.0088715805,
0.0054280492,
-0.02348782,
0.012233512,
-0.016737847,
-0.041048195,
-0.026529877,
0.02061549,
-0.024623696,
0.008499484,
-0.0009947072,
-0.0047621913,
-0.0145052625,
0.014661935,
0.005222417,
-0.01058845,
-0.0018115258,
-0.009015197,
0.010575394,
0.012246568,
0.009491743,
0.0012639881,
-0.00049204956,
-0.018121786,
0.016058931,
0.18006893,
0.005594514,
0.010151072,
0.013134378,
-0.010843043,
-0.016998967,
0.0036295797,
-0.0135130035,
-0.016058931,
-0.011045411,
0.014022189,
-0.0010901795,
0.008616988,
-0.0020236864,
0.031987302,
-0.005698962,
-0.025903188,
-0.013813293,
-0.02094189,
-0.032613993,
-0.0073374957,
-0.017703993,
0.0107712345,
-0.005969875,
0.017939001,
0.008414619,
-0.027026007,
0.0020041023,
0.030498914,
0.0051963045,
-0.0016956534,
0.0067499736,
0.004357454,
-0.0124032395,
0.030263906,
0.001233796,
0.00067238614,
-0.022678345,
-0.020693827,
-0.019531839,
-0.02793993,
0.035642996,
-0.011430565,
0.004951504,
-0.009230622,
0.010203297,
-0.0045728786,
-0.018683197,
-0.006547605,
0.009589663,
-0.038828667,
-0.004040845,
0.011234724,
0.035982452,
-0.015066672,
-0.013186603,
0.029611103,
-0.008368923,
-0.015066672,
0.026843222,
-0.008264475,
0.0003737292,
-0.012122535,
0.004602255,
-0.031021155,
0.026542934,
-0.0199888,
-0.022717513,
-0.004047373,
-0.014335535,
0.024101453,
-0.010679842,
-0.010033568,
0.009517855,
-0.022978634,
-0.0072656875,
0.020798275,
0.015562803,
0.013813293,
0.020315202,
-0.008630044,
-0.005787091,
-0.026451541,
0.005878483,
-0.0020612227,
-0.03146506,
0.016933687,
0.022338888,
-0.021268293,
-0.0042138374,
0.017965114,
0.017638713,
-0.00047736155,
-0.014204973,
0.009903008,
-0.022391113,
0.014531375,
-0.012246568,
-0.009818143,
-0.0026585367,
-0.022365,
0.078492925,
-0.010209825,
-0.0064366288,
-0.019257663,
0.017860666,
-0.022247495,
0.014779439,
-0.0099944,
0.0036295797,
-0.01058845,
-0.03820198,
0.0016793334,
0.0014533007,
-0.0010869155,
0.029480543,
0.020524098,
-0.029976673,
0.031125605,
-0.0072591593,
-0.010634147,
-0.010692898,
0.023997005,
0.02305697,
-0.018552635,
-0.0013496684,
-0.035878003,
0.013362859,
-0.016398389,
-0.042275462,
0.0039037566,
0.0052126246,
0.0072983275,
0.022247495,
0.022182215,
0.0030045216,
0.004390094,
0.011123748,
0.0011105796,
0.024845649,
-0.010412194,
-0.009054366,
0.011802662,
0.004024525,
-0.012631721,
-0.01741676,
0.012912425,
0.0029947297,
-0.024702031,
-0.010790818,
-0.008140442,
-0.032796778,
-0.0006458661,
-0.013291051,
0.0045206547,
-0.017769273,
0.0091065895,
-0.042954378,
0.0039037566,
0.004625103,
-0.015171121,
0.030394467,
0.025785683,
0.014936112,
-0.010660258,
0.005339921,
-0.16220826,
0.01579781,
-0.0057283384,
-0.023148363,
0.039298687,
0.019283773,
-0.0007499064,
-0.00186375,
-0.01378718,
-0.007213463,
0.026373206,
-0.004749135,
-0.026177363,
-0.008310171,
0.026947672,
-0.018657085,
0.009478686,
0.024832591,
0.01897043,
0.0048470558,
-0.0018996542,
-0.027861593,
0.025837908,
0.002230951,
0.016085044,
0.026490709,
0.006887062,
0.0054378416,
0.0016417973,
0.01897043,
-0.012142119,
-0.005858899,
0.029271645,
0.01853958,
0.023213644,
-0.014688048,
0.014988337,
-0.004674063,
0.007957658,
-0.0057936185,
0.0191271,
0.0038972285,
-0.0005561058,
-0.015850035,
-0.033136234,
0.03848921,
-0.011861415,
-0.030838372,
0.041152645,
-0.0063648205,
0.021359684,
0.0035871475,
0.022952521,
0.021986375,
0.028592732,
-0.009087006,
-0.0020661186,
-0.0061852997,
-0.0079119615,
0.006279956,
-0.015850035,
-0.019727679,
0.032352872,
0.0029865697,
0.020928835,
-0.032170087,
0.0014598287,
-0.007977242,
-0.03431128,
0.0036328437,
-0.025198162,
-0.026869334,
0.000625466,
-0.007774873,
0.015040561,
-0.000934323,
-0.008016409,
0.025720403,
-0.020014912,
0.011397924,
-0.024884816,
0.005232209,
-0.02035437,
-0.030081121,
-0.022678345,
0.0035545074,
0.007441944,
0.012122535,
-0.015941428,
0.011737382,
0.024414798,
-0.028201051,
-0.014609711,
-0.029428318,
0.012344488,
0.02249556,
-0.0032313704,
-0.0015275569,
-0.02932387,
-0.0070045665,
0.02982,
-0.018147899,
-0.021881927,
-0.00043656141,
0.044390544,
0.0069392864,
-0.008368923,
-0.00425627,
0.04284993,
-0.01672479,
0.0048568477,
-0.016385334,
-0.004696911,
0.022586953,
-0.009922592,
0.045304466,
0.012768809,
-0.0047589275,
0.0012990761,
-0.017012022,
0.06736918,
0.0063485005,
-0.017952058,
0.022090822,
-0.0169598,
-0.012155175,
-0.14058746,
-0.02055021,
0.0045108628,
0.028305499,
0.011672102,
0.022221383,
-0.009184926,
0.011267364,
-0.0030926499,
0.024754256,
-0.023291979,
-0.017168695,
-0.0086365715,
-0.02190804,
0.023461707,
0.003433739,
-0.014413871,
0.022835018,
-0.021542469,
0.029558878,
-0.018330684,
-0.02087661,
-0.012716585,
-0.02374894,
0.0041550854,
-0.010516642,
-0.019806016,
0.005587986,
-0.0043182857,
0.026007636,
0.020994116,
0.008754076,
0.018265402,
-0.0037144439,
-0.016737847,
-0.019662399,
0.028201051,
-0.007461528,
0.032248423,
-0.024218958,
-0.0149752805,
0.011978919,
0.03397182,
-0.002505128,
0.039115902,
-0.0036361078,
-0.03671359,
0.010399138,
0.018774588,
-0.01936211,
-0.032143977,
-0.0032476904,
-0.026229588,
-0.022665288,
0.02692156,
-0.009002141,
0.028096603,
0.019610176,
-0.052041385,
0.006616149,
-0.0033080745,
0.012266152,
-0.0191271,
0.0056859064,
0.0352252,
-0.026947672,
-0.0046871193,
-0.020067137,
0.016111156,
-0.022129992,
-0.0031677221,
0.016346164,
-0.005852371,
-0.030290017,
-0.020054081,
0.018330684,
-0.010862627,
0.00014749248,
0.026242644,
-0.0050657443,
-0.012037671,
0.002124871,
0.01679007,
0.005907859,
-0.010686371,
0.016476724,
0.014779439,
0.0072591593,
0.0011130276,
-0.0100988485,
0.0030175778,
0.029428318,
0.01378718,
-0.029767776,
-0.0076900087,
0.01873542,
-0.019897409,
0.0015202129,
0.046322837,
0.005042896,
-0.043032713,
-0.037392505,
-0.046792854,
0.02757436,
0.00088944286,
0.0001833966,
-0.011136804,
-0.00430523,
0.005294225,
0.006802198,
-0.012226983,
0.022900298,
-0.002789097,
-0.0005471298,
0.005000464,
-0.0017658297,
-0.03143895,
0.006580245,
0.03044669,
0.010144545,
0.014596655,
0.0066128853,
-0.009015197,
-0.0009955232,
-0.015262513,
0.023148363,
-0.016803127,
0.009080477,
0.009041309,
0.00039331327,
-0.013049514,
0.007095959,
0.010248993,
-0.04096986,
-0.021712197,
-0.013734956,
-0.023174474,
-0.026399316,
-0.014439982,
0.009759392,
0.037157495,
0.022129992,
-0.022900298,
0.007853209,
-0.005813203,
0.0015765171,
0.01659423,
0.01346078,
-0.025877075,
0.01289937,
-0.0072852713,
-0.012625192,
0.021307461,
0.009243677,
-0.021424964,
-0.0011285316,
-0.029793888,
-0.0051081763,
-0.03446795,
-0.0072526312,
-0.015836978,
-0.0042268937,
0.013969965,
-0.012174759,
0.0032199463,
0.023605324,
0.01534085,
0.002510024,
-0.00692623,
-0.014204973,
0.027966043,
-0.007944602,
-0.021712197,
-0.00047246553,
0.0036328437,
-0.007703065,
0.00044798545,
0.017599545,
-0.0054052016,
0.021020228,
-0.01689452,
0.015876148,
-0.010379554,
-0.012618665,
-0.026464596,
0.0036589557,
0.049351837,
-0.007866265,
0.023670604,
0.008623516,
0.010092321,
0.001260724,
0.005610834,
0.023239754,
0.0022619592,
0.011064996,
-0.0035316595,
0.010940963,
-0.008414619,
0.0018164219,
-0.007951129,
0.024610639,
0.004709967,
0.01748204,
0.0042268937,
-0.015145008,
-0.014361646,
0.016881462,
-0.018630972,
-0.028253276,
0.0029147614,
-0.0025475603,
0.013539116,
0.0122008715,
0.0060220994,
0.0038254203,
-0.0011048676,
0.02094189,
-0.023905613,
0.013552171,
0.0088063,
0.036609143,
0.004543503,
0.017012022,
0.009557023,
0.0123183755,
0.04188378,
-0.0139830215,
0.039011452,
-0.044677775,
0.025916243,
-0.02843606,
0.011978919,
-0.013930797,
-0.040160384,
-0.004429262,
0.007507224,
-0.015510578,
0.023187531,
0.016972855,
-0.0073374957,
0.072226025,
-0.0015242929,
-0.03984704,
-0.0017527736,
0.011463205,
0.0062179402,
0.007879321,
0.02124218,
0.00087312283,
-0.02595541,
0.021216068,
-0.01121514,
0.028409947,
-0.048333466,
-0.02374894,
0.0069849826,
-0.011254308,
0.0022276873,
0.005911123,
0.014361646,
0.0054508974,
-0.0006834022,
-0.0079119615,
0.023513932,
-0.024662863,
0.015562803,
0.048829596,
-0.008943389,
0.003443531,
-0.012586025,
-0.001557749,
0.008930333,
-0.026334036,
-0.004922128,
0.002198311,
-0.017103415,
-0.009328542,
0.0001860486,
0.006736918,
-0.014557487,
-0.024532303,
0.023840332,
-0.0025034961,
-0.023331147,
-0.013813293,
-0.032613993,
-0.014492206,
0.001850694,
-0.0028511132
] |
Testosterone (T) and its 5alpha-reduced metabolite, dihydrotestosterone (DHT), can decrease anxiety-like behavior; however, the mechanisms underlying these effects have not been established. First, we hypothesized that if T reduces anxiety-like behavior through actions of its 5alpha-reduced metabolite, DHT, then gonadectomy (GDX) would increase anxiety-like behavior, an effect which would be reversed by systemic administration of DHT. Second, we hypothesized that if T and DHT reduce anxiety-like behavior in part through actions at intracellular androgen receptors in the hippocampus, then administration of | [
-0.032493915,
0.0030611889,
0.02008378,
-0.03609259,
-0.021459743,
0.009651592,
-0.049799304,
-0.028366024,
-0.0039592036,
-0.017517079,
0.0008765154,
0.027056212,
0.01335611,
0.030562274,
-0.009175297,
0.017490616,
0.041411217,
0.0038996667,
0.0031455327,
-0.0058147702,
-0.005665928,
-0.0058280006,
0.007984559,
0.0016538027,
-0.005973535,
-0.007918407,
0.034425557,
-0.030271204,
-0.0063406792,
0.009261295,
0.012787202,
-0.005222709,
-0.029715527,
-0.029583221,
0.011755229,
0.008004405,
0.0048919483,
0.00088478444,
0.0009964161,
-0.018813659,
0.019753018,
-0.017636152,
0.0069922777,
-0.008447624,
0.0010749717,
-0.0050242525,
-0.00094101374,
-0.030006595,
-0.005606391,
0.013409032,
0.013329649,
0.010094811,
-0.009592055,
0.0071047363,
0.0008306224,
0.0020341773,
0.016868787,
-0.0028528096,
0.011728768,
-0.010438803,
0.002775081,
-0.00691951,
-0.0014652691,
0.025891935,
-0.01208599,
0.0036747495,
0.005573315,
0.007885331,
-0.0039360505,
-0.005222709,
0.017159857,
0.024859961,
-0.019607484,
0.006562289,
0.016736483,
-0.00051226537,
-0.0071510426,
-0.011470775,
0.013197346,
-0.013309804,
0.03045643,
-0.015029758,
-0.01823152,
0.011040786,
0.023722146,
0.0006611076,
0.0148974545,
0.020480692,
0.0026609686,
-0.006813667,
0.016286649,
0.021261288,
0.020679148,
0.043422244,
0.0027188517,
0.01629988,
-0.00971113,
0.023166468,
-0.03363173,
-0.03207054,
-0.005973535,
-0.0039988947,
-0.013230422,
-0.020652687,
0.003754132,
-0.016749714,
-0.00722381,
-0.006621826,
0.0033737575,
-0.014963606,
-0.017424464,
0.025878703,
-0.018615203,
-0.06244759,
-0.0012982351,
0.010094811,
0.022081573,
0.0032778368,
-0.002598124,
-0.007977944,
0.009578825,
0.0074950336,
0.027995571,
-0.0009128991,
-0.0110870935,
0.010392496,
-0.0146063855,
-0.008116864,
0.0003851293,
-0.011219397,
0.024317514,
0.014288855,
0.0005445145,
0.022650482,
-0.030218283,
0.010134502,
-0.015320828,
-0.012171987,
-0.018138908,
-0.044639442,
-0.0075479555,
0.015942657,
-0.01538698,
0.010022044,
-0.02390737,
0.03603967,
0.028948162,
0.004425576,
0.015294367,
0.0077464115,
-0.015214984,
-0.021472974,
0.014844533,
-0.010266807,
-0.0018721046,
0.03267914,
0.0070848907,
0.020639457,
-0.00069377024,
0.001626515,
0.0126813585,
-0.022452025,
0.007984559,
-0.011642771,
0.015082681,
0.022703404,
0.01569128,
0.014011016,
-0.0072767315,
-0.029106926,
0.006109147,
0.008361626,
-0.03699226,
0.01849613,
-0.017133396,
0.0313561,
-0.0032662603,
0.011106939,
0.013667026,
-0.011827997,
-0.026328538,
-0.01567805,
0.012337368,
0.008606389,
-0.0034928313,
0.010491724,
-0.0022690173,
-0.0064299847,
-0.011120169,
-0.019581024,
-0.023603072,
0.015863275,
-0.023087084,
-0.015942657,
-0.62659276,
0.0039691264,
0.013997786,
-0.0053583207,
0.028022032,
0.020665918,
0.0003613559,
0.026196234,
-0.0105248,
0.014659307,
0.013984555,
0.025336256,
-0.00957221,
-0.044745285,
0.013104732,
-0.011186321,
-0.0018721046,
-0.010478494,
0.020520383,
-0.0036912875,
-0.018046295,
-0.0022094804,
-0.0037144409,
-0.015598667,
0.02889524,
-0.010815869,
0.013627334,
0.0022078266,
0.0008599774,
0.025614096,
0.003562291,
0.017239239,
0.0089834565,
0.014037477,
0.05215432,
-0.015545745,
-0.0052657076,
0.007918407,
0.008044096,
0.053636126,
-0.009334062,
-0.008990072,
0.024119059,
0.010458648,
-0.0163528,
0.015730971,
0.0033142206,
-0.006158761,
0.014143321,
0.008249167,
-0.00030223242,
-0.0111334,
0.011794921,
-0.0031124565,
-0.0039261277,
0.005956997,
0.011841227,
-0.024092598,
-0.010160964,
0.01659095,
0.015757432,
0.026328538,
-0.007865486,
0.0036251354,
-0.016432183,
0.04212566,
-0.019395798,
0.004098123,
0.00066234794,
0.01757,
-0.0033638347,
0.034108028,
-0.019025346,
0.0040022023,
0.030403508,
0.030721039,
0.018694585,
0.0013900212,
-0.004551265,
0.024952574,
0.01053803,
0.014050707,
-0.021843426,
0.0013156,
0.046200633,
-0.018641664,
-0.004031971,
0.0039525884,
0.008745308,
-0.0010873752,
0.02767804,
0.020017628,
-0.021155443,
-0.016670331,
0.0061819144,
0.015916197,
-0.0072436556,
0.0013271767,
0.035378147,
-0.018257981,
-0.012912891,
0.0005333514,
0.0143153155,
0.0059239212,
0.008295475,
-0.006638364,
-0.046306476,
0.010888637,
0.03895036,
-0.0027767348,
-0.00021054976,
0.0033224896,
-0.027360512,
0.0030859958,
0.019673636,
-0.012840124,
0.021420052,
-0.014579925,
0.017821377,
-0.035960287,
0.007567801,
-0.009095915,
0.010617414,
0.012615207,
0.030244743,
0.019091498,
0.0057684635,
-0.010637259,
-0.020044088,
-0.009565595,
-0.0012544093,
0.013078271,
0.011232628,
-0.0091620665,
0.023708915,
0.009029763,
0.031620707,
-0.0022409025,
0.00432304,
-0.03553691,
-0.026090391,
-0.00424035,
-0.006218298,
0.013098117,
-0.017239239,
-0.027439894,
-0.013217191,
0.0007367691,
-0.009386984,
-0.0047794897,
0.0031620706,
-0.010445418,
0.004809258,
0.028657092,
-0.021936039,
-0.005639467,
0.012952583,
-0.000097729404,
-0.0034399095,
0.0054509337,
0.00722381,
0.020851145,
-0.029927213,
-0.0033902954,
-0.041993357,
-0.03416095,
0.002841233,
0.02575963,
-0.011338471,
-0.026196234,
-0.009558979,
-0.029609682,
0.0044718822,
-0.0014049053,
-0.0019349491,
0.009764051,
0.011900764,
-0.0051797098,
0.0030909572,
0.002823041,
-0.017702304,
0.017490616,
-0.01381256,
-0.004934947,
0.0369658,
-0.0027221593,
0.018906273,
0.02228003,
0.0017282238,
-0.0013007158,
-0.03643658,
0.037891928,
0.004041894,
0.0027800424,
-0.019237032,
-0.01633957,
0.04871441,
0.015836814,
-0.027386973,
0.013276728,
0.017437695,
-0.033420045,
0.014963606,
-0.020904066,
0.015889736,
-0.023417845,
-0.0131179625,
-0.0002056917,
-0.0014214434,
0.0154399015,
-0.00925468,
-0.029609682,
-0.016471874,
0.007885331,
-0.008441009,
0.009386984,
-0.0076802596,
0.0022160956,
-0.0055633923,
-0.000930264,
-0.00017003159,
-0.011867688,
0.010690181,
0.002482358,
-0.031197334,
0.022663713,
0.024132289,
-0.014884224,
-0.008050712,
-0.026593147,
-0.0039426656,
0.009347293,
-0.009830203,
-0.0030049596,
0.01477838,
0.024502741,
-0.01099448,
0.00053004373,
0.028418945,
0.005725465,
0.010220501,
-0.007733181,
0.040114637,
-0.028921701,
0.018138908,
0.015916197,
0.03887098,
0.0111598605,
0.01600881,
0.0078059486,
0.019197341,
0.013243652,
0.0075876466,
-0.031647168,
0.0169614,
0.0030132285,
0.018747507,
0.0155854365,
0.019938245,
0.024277823,
0.040961385,
0.003965819,
0.02857771,
-0.013144423,
0.014011016,
0.021459743,
0.011391393,
0.016934939,
-0.020493923,
0.009955892,
-0.01207276,
0.027995571,
0.0024773963,
-0.040273402,
0.01606173,
0.012635052,
0.018800428,
-0.00533186,
0.016524795,
0.00722381,
-0.006730977,
-0.032837905,
0.008097018,
0.02607716,
0.0041775056,
-0.01823152,
-0.0064299847,
-0.006724362,
0.014355008,
0.02324585,
-0.011153245,
0.009843433,
0.014183012,
0.0011262397,
-0.0048489496,
-0.014090398,
-0.018919503,
0.016273418,
0.0093076015,
-0.012707819,
0.0076736445,
0.012582131,
-0.018284442,
-0.0032232613,
0.022174187,
0.0018191829,
-0.029768448,
-0.025058419,
0.012535824,
-0.011735383,
0.03511354,
0.0060231495,
-0.0099625075,
0.007349499,
0.0010964712,
-0.0034167564,
-0.018033065,
-0.0010104735,
-0.005520393,
-0.0065159826,
-0.020520383,
-0.0050143297,
-0.007561186,
-0.006840128,
0.04395146,
0.01098125,
-0.02320616,
-0.00090132246,
0.011153245,
0.025918396,
-0.0055005476,
-0.026765142,
0.019395798,
0.018271212,
-0.01850936,
0.007098121,
-0.001860528,
-0.008930534,
0.01850936,
0.015466362,
-0.017040784,
-0.027334051,
-0.020507153,
-0.0034002182,
0.011457545,
0.009512673,
-0.006611903,
0.038182996,
0.036198433,
0.002966922,
-0.0027386972,
0.03582798,
0.0040385863,
-0.019065037,
0.00502756,
0.019700097,
0.0080374805,
0.032732062,
-0.008579928,
-0.0009773974,
-0.029106926,
0.015810354,
-0.0043825773,
-0.037521474,
-0.0025865473,
0.022968011,
0.02419844,
-0.0071179667,
0.0032629527,
-0.01114663,
0.0109415585,
-0.0030595348,
-0.0125689,
0.00055857183,
-0.019025346,
-0.013891943,
-0.01147739,
-0.01944872,
0.002966922,
-0.0034729857,
0.008904073,
-0.010339574,
-0.031197334,
0.007951483,
-0.013309804,
-0.014527002,
0.016710022,
-0.02009701,
0.002212788,
-0.0154399015,
-0.005411242,
-0.013878712,
-0.007435497,
-0.009863279,
0.009651592,
-0.0018324134,
-0.018284442,
0.0089834565,
0.017173087,
0.0020540229,
0.019237032,
-0.006605288,
-0.00012941007,
0.018919503,
-0.04022048,
-0.0091620665,
-0.008613004,
-0.0007607492,
0.044216067,
-0.00029003565,
-0.0069790473,
-0.010399112,
0.0021085984,
0.003803746,
-0.019700097,
-0.013600873,
0.011318626,
-0.039691266,
-0.007065045,
0.00019897314,
0.019620715,
0.015942657,
0.0033969106,
-0.009208373,
-0.019528102,
-0.021658199,
-0.018813659,
-0.03641012,
0.00971113,
-0.018033065,
-0.004855565,
0.022531407,
-0.0039426656,
-0.019250263,
0.027201746,
-0.008560083,
-0.009975738,
0.004167583,
0.025402408,
-0.003588752,
-0.0068996646,
0.017662613,
-0.014579925,
0.0072436556,
0.007700105,
-0.024754118,
0.034663703,
0.021089291,
-0.025164261,
0.004213889,
-0.0017712227,
-0.0030529196,
-0.036515962,
0.020665918,
-0.014328546,
0.00896361,
-0.015836814,
-0.03611905,
-0.021697892,
0.0006941837,
-0.038500525,
-0.003185224,
0.011768459,
-0.026302077,
-0.032758523,
-0.006350602,
-0.03328774,
-0.00769349,
0.047179684,
-0.033711113,
-0.035722136,
0.018998886,
-0.008216091,
0.012668128,
-0.026209464,
-0.006654902,
-0.03646304,
-0.0005933017,
-0.0047993353,
-0.046280015,
0.02606393,
-0.008103633,
0.0012329099,
0.013680256,
0.028710015,
-0.008209476,
-0.0006491176,
0.041649368,
0.0034829085,
0.000011731663,
0.0037177484,
0.035775058,
-0.014222703,
0.016127884,
0.026897447,
-0.009869894,
0.025362717,
-0.013680256,
0.0301389,
0.011404623,
-0.0043792697,
-0.017636152,
-0.0019084882,
-0.026249155,
-0.0039095897,
-0.0017894144,
-0.012707819,
-0.005722157,
-0.027519276,
-0.009340677,
0.037891928,
0.007567801,
0.015955888,
-0.025296565,
0.010571106,
-0.0036648267,
0.0040452015,
0.017689073,
-0.008824691,
0.0045876484,
-0.03357881,
0.017358312,
-0.012833509,
0.005847846,
-0.021089291,
0.030615196,
0.0034167564,
0.0006888088,
-0.007991174,
0.0032133386,
-0.005520393,
0.032546837,
-0.01241675,
-0.010134502,
-0.017173087,
0.003342335,
-0.0018820275,
-0.02700329,
-0.004855565,
0.019739788,
-0.008070557,
0.03799777,
0.0014942107,
-0.015016528,
0.0033754113,
-0.0067739757,
0.027730962,
-0.023126777,
0.016458644,
0.01241675,
-0.0033406813,
-0.00060570525,
-0.006092609,
0.0070782756,
-0.006840128,
0.022332951,
0.020798223,
-0.0046967994,
-0.022425564,
0.007435497,
-0.0014545195,
-0.044374835,
-0.029689066,
-0.0068599735,
0.009155451,
-0.002598124,
-0.015572206,
0.0026526994,
-0.029371535,
-0.00973759,
-0.00015318347,
-0.013270113,
-0.0019316415,
-0.027598659,
-0.008044096,
0.02007055,
-0.012515979,
0.008857767,
-0.02038808,
0.030959185,
-0.009856664,
-0.018363824,
-0.046015404,
0.013151038,
-0.0040452015,
0.025547944,
-0.017728765,
0.0039459732,
0.004534727,
0.012291062,
0.000007874944,
-0.012496133,
-0.014527002,
0.04019402,
-0.0107960235,
0.016233727,
0.027334051,
-0.0073958053,
0.007931638,
0.0048820255,
0.018707816,
-0.0051929406,
-0.013653795,
0.0011452583,
0.028101414,
0.003049612,
-0.0047199526,
0.009790512,
-0.02606393,
-0.010716641,
-0.008593159,
-0.021618508,
0.0163528,
-0.04119953,
0.003486216,
0.023748606,
-0.00802425,
0.035642754,
0.0019002192,
-0.012238139,
0.004541342,
0.019078268,
-0.009618516,
0.03140902,
0.031488404,
0.017411234,
-0.047206145,
-0.0027039673,
0.0047199526,
-0.014963606,
0.010174194,
-0.039426655,
-0.015254675,
-0.018125677,
0.009638362,
-0.001827452,
0.0020639456,
0.014063938,
-0.011457545,
-0.014302085,
0.01700109,
0.007038584,
-0.024370436,
0.012211679,
0.0025468562,
-0.016683562,
-0.0029619606,
-0.016418952,
-0.01537375,
-0.026341768,
0.017702304,
0.012595361,
-0.011735383,
0.010405727,
-0.021896347,
-0.00043949805,
-0.0014909031,
-0.0102866525,
-0.008321935,
0.0018076063,
-0.017530309,
0.026632838,
0.0037111333,
0.019409029,
-0.021142213,
-0.00066937663,
0.0046240324,
-0.012965813,
-0.01980594,
-0.012939352,
-0.011728768,
-0.004584341,
-0.061495,
0.0022723249,
0.000980705,
0.016141115,
0.01477838,
-0.015757432,
-0.010458648,
0.019581024,
-0.019951476,
-0.0069459714,
0.01947518,
-0.0023417845,
0.0038070537,
0.030218283,
-0.010412342,
0.00738919,
0.01506945,
-0.0025253566,
-0.0058842297,
-0.021578817,
0.0017414542,
-0.019104728,
0.028710015,
0.0066185184,
-0.038421143,
-0.025667017,
0.012198448,
-0.029768448,
-0.0022491717,
0.0074156513,
-0.001072491,
0.02669899,
-0.024251362,
0.010954789,
0.0132634975,
-0.013878712,
-0.025931627,
-0.016366031,
0.0072304253,
0.0025518176,
0.002540241,
-0.008249167,
-0.025217183,
-0.008341781,
-0.0016149383,
-0.009909585,
-0.035272304,
0.000120417506,
0.025878703,
-0.019753018,
0.017503848,
0.03080042,
-0.008441009,
-0.013680256,
-0.0044784974,
-0.0017728765,
-0.0073627294,
-0.017768456,
-0.0035358302,
-0.0037574396,
-0.010167579,
-0.0012577169,
-0.014500542,
0.011656001,
0.006585442,
-0.028286641,
0.049031943,
-0.019858863,
0.0021267901,
-0.0023566687,
0.03548399,
-0.0025237028,
-0.024555663,
-0.009393599,
0.0015256329,
0.0052822456,
0.012476287,
-0.006529213,
0.005321937,
-0.019673636,
-0.014196242,
0.012793818,
-0.012979044,
0.017636152,
-0.011675847,
0.009684669,
-0.011556773,
-0.00957221,
0.1947518,
-0.008097018,
-0.007031969,
0.007164273,
0.008050712,
-0.005308707,
0.03363173,
-0.022134494,
0.00015070276,
-0.0011750268,
0.023153238,
0.004885333,
-0.017093705,
0.003502754,
0.009644977,
-0.030191822,
-0.027122363,
-0.0023517073,
0.008044096,
-0.008434393,
0.008738693,
-0.0024244748,
0.01004189,
-0.013653795,
0.035775058,
-0.0022673635,
0.005917306,
-0.009274526,
0.00014046987,
0.00184399,
-0.0069922777,
-0.003995587,
0.02573317,
-0.007475188,
-0.006502752,
-0.015241445,
-0.019753018,
-0.005447626,
-0.010908483,
-0.02417198,
0.015545745,
-0.014950376,
-0.02132744,
-0.009704514,
0.0031554555,
0.00035598103,
0.0025518176,
-0.010266807,
0.0021069446,
-0.00066317484,
-0.044454217,
0.012919506,
0.035298765,
0.039109126,
-0.0014065591,
-0.017490616,
0.024423357,
0.01729216,
-0.0013139462,
0.011662616,
-0.01725247,
-0.0100683505,
-0.0213539,
0.03225577,
-0.03768024,
0.024648275,
-0.014712228,
0.01755677,
0.010253577,
0.019964706,
0.021565586,
0.0013189076,
-0.029768448,
0.014712228,
-0.011226012,
0.0044288835,
0.03299667,
0.033393584,
0.0016066693,
-0.015122372,
0.0070848907,
0.010134502,
0.021446513,
0.021380361,
-0.010220501,
-0.013772869,
0.016458644,
-0.020956988,
-0.044136684,
0.00274862,
-0.007872101,
-0.022769555,
-0.0021747504,
-0.012687974,
0.01697463,
0.0027535814,
0.018734276,
-0.006770668,
-0.0025170876,
-0.014262394,
-0.015016528,
0.08239906,
0.02198896,
0.022676943,
-0.0026708914,
-0.00044900744,
-0.013931634,
0.025415638,
-0.015029758,
0.00971113,
0.0040286635,
-0.02950384,
0.019647175,
-0.011113554,
0.0050407904,
0.016458644,
0.019329645,
-0.014421159,
-0.006052918,
-0.0030512658,
0.005639467,
-0.014328546,
0.020612996,
0.03799777,
-0.0014735382,
0.002035831,
-0.010147734,
-0.026672529,
-0.0043693464,
-0.03611905,
0.013653795,
-0.029477378,
-0.003965819,
-0.012522594,
0.004098123,
0.0033456427,
0.025481792,
-0.0084807,
-0.013217191,
0.027572198,
-0.0020424463,
0.0038368222,
0.014262394,
0.015095911,
0.01099448,
-0.03609259,
0.00990297,
-0.0026775065,
-0.026090391,
-0.004366039,
-0.033155438,
-0.018694585,
-0.0040286635,
0.0120661445,
0.0037177484,
-0.011589849,
-0.00013437147,
-0.045592032,
-0.004633955,
0.02419844,
-0.009009917,
-0.0018654894,
0.0045545725,
-0.019488411,
-0.018152138,
-0.006787206,
-0.16543318,
0.018760737,
0.03799777,
-0.02918631,
0.020837914,
0.0111334,
0.030641656,
0.006486214,
0.00074793224,
0.0020011012,
0.0085468525,
0.013534721,
-0.0057519255,
0.0002480704,
0.003226569,
0.007435497,
0.0040154327,
-0.014540233,
0.019342875,
0.025812551,
0.0049051787,
-0.014037477,
0.015294367,
-0.022716634,
0.006787206,
0.024463048,
0.006459753,
0.007865486,
-0.0017579922,
-0.014011016,
-0.032917287,
0.0054343957,
0.024502741,
0.0013437147,
0.029768448,
0.0057783867,
0.0052194013,
-0.018734276,
-0.032917287,
0.0009914547,
0.011338471,
0.00239636,
-0.014672537,
0.007925022,
-0.024859961,
-0.0029024237,
-0.014183012,
-0.010829099,
0.015823584,
-0.012046299,
0.0041245837,
0.0057353876,
0.021711122,
0.012747511,
0.044348374,
-0.0047265682,
0.024529202,
0.025958087,
0.004855565,
-0.024873191,
-0.013078271,
-0.006813667,
0.023179699,
0.011278934,
0.010657105,
-0.017715534,
-0.011424469,
-0.010485109,
-0.03638366,
0.008520392,
-0.038182996,
-0.00814994,
0.017239239,
-0.0066350563,
0.0105248,
0.020216083,
-0.01887981,
0.006042995,
0.021525895,
0.01381256,
-0.0027006597,
-0.0059371516,
-0.021816965,
-0.016233727,
-0.026579916,
0.045644954,
0.009095915,
-0.009042993,
0.004736491,
0.0128268935,
0.03889744,
-0.017847838,
-0.015479593,
-0.00690628,
-0.019223802,
-0.005229324,
0.018178599,
-0.009049608,
-0.00038761,
-0.0059966883,
0.019938245,
-0.020890836,
-0.004022048,
-0.012317522,
-0.0030992262,
0.00863285,
-0.03207054,
0.0022425563,
0.0013949826,
0.0017001091,
-0.009446521,
0.009076069,
0.0013734831,
0.010127887,
-0.0061885295,
0.048767332,
0.016141115,
-0.029133387,
0.009757436,
0.0128732,
0.060330722,
0.029424457,
0.0018704508,
0.0028991161,
-0.012992274,
-0.028418945,
-0.124789335,
-0.026950369,
-0.014368238,
0.016498335,
0.0075545707,
0.028657092,
-0.00043288284,
0.029715527,
-0.013488415,
0.03982357,
-0.031144412,
0.00667144,
-0.01918411,
-0.02984783,
0.023364924,
-0.035298765,
-0.0019432182,
-0.0077530267,
0.0051168655,
0.04363393,
-0.0010766255,
-0.021883117,
0.00042316676,
-0.011080478,
0.0022574407,
-0.019673636,
-0.008778385,
0.018390285,
0.0029388072,
0.0023632841,
-0.005956997,
0.018575512,
0.03699226,
-0.004465267,
-0.014910685,
-0.0094531365,
-0.0062745274,
-0.02323262,
0.0401411,
-0.0022723249,
-0.011689077,
0.029054005,
0.023483997,
0.012998889,
0.01537375,
-0.017675843,
-0.024661506,
0.00573208,
0.0020804838,
-0.00075082644,
-0.05022268,
-0.01730539,
-0.0066085956,
-0.004584341,
0.03048289,
0.019329645,
0.033155438,
0.04175521,
-0.036277816,
-0.016445413,
-0.0020655994,
0.014368238,
0.005255785,
0.015281137,
0.013402416,
-0.011391393,
-0.0050176373,
-0.027519276,
0.005983458,
-0.015717741,
-0.018046295,
0.012833509,
-0.015850045,
-0.023047393,
-0.032149922,
0.025375947,
-0.00675413,
-0.010657105,
0.022425564,
-0.0034564475,
-0.011867688,
-0.005894153,
0.011907379,
-0.00722381,
0.0018737584,
0.010498339,
0.009697899,
-0.006787206,
0.0067607453,
-0.02321939,
-0.027836807,
0.021168673,
-0.017622922,
-0.028445406,
-0.0022987856,
-0.0049151015,
0.006628441,
-0.0046802615,
0.028366024,
0.011192936,
-0.013289958,
-0.029345075,
-0.048423342,
0.016538026,
0.013276728,
0.0090892995,
-0.00016155584,
-0.01730539,
0.035642754,
0.006552366,
-0.007977944,
-0.0155854365,
-0.018972425,
0.0024906269,
0.0034399095,
-0.026156543,
-0.036224894,
-0.028207257,
0.014302085,
-0.010822484,
0.023060624,
0.02886878,
0.01099448,
0.010782793,
-0.00057097536,
0.014421159,
-0.012912891,
0.0031736472,
0.0013089848,
0.005308707,
-0.007786103,
-0.0140242465,
0.0056030834,
-0.018694585,
-0.011140015,
-0.014421159,
-0.029609682,
0.0026047393,
-0.0024211672,
0.019991167,
0.0034829085,
0.022504946,
-0.022346182,
-0.025309796,
0.008877613,
-0.037600856,
0.00620176,
0.0014644422,
-0.0483175,
0.01600881,
0.004041894,
-0.015638359,
0.024476279,
0.009631746,
-0.005589853,
-0.017146626,
-0.020149931,
-0.0068665887,
-0.01790076,
-0.018072756,
-0.027056212,
0.040088177,
0.0047993353,
0.031144412,
-0.0059139985,
-0.027201746,
0.025005497,
-0.017014321,
-0.03603967,
-0.018165369,
0.02324585,
-0.0039823567,
-0.023523688,
-0.014474081,
0.005857769,
0.0013891943,
-0.0008690733,
-0.0074553424,
-0.013448724,
-0.0030165361,
-0.03138256,
0.011556773,
0.021459743,
-0.013243652,
-0.021009909,
0.008930534,
0.025336256,
0.0070782756,
0.004852257,
0.01066372,
0.017490616,
0.009843433,
0.0004161381,
-0.004759644,
-0.0034035258,
0.00783241,
0.0032381457,
0.024727657,
-0.0023202852,
-0.004207274,
0.018654894,
0.025005497,
0.02767804,
0.014183012,
-0.002556779,
-0.016934939,
-0.0068599735,
0.01349503,
-0.02386768,
-0.0369658,
0.002130098,
-0.00067103043,
0.005037483,
-0.015545745,
0.0012544093,
-0.0034167564,
0.00155044,
0.01631311,
-0.009148836,
0.005050713,
-0.022743095,
0.030165361,
-0.0047397986,
0.026460843,
-0.005044098,
0.015770663,
0.056044064,
-0.027757425,
0.031144412,
-0.022174187,
0.004590956,
0.004114661,
0.007925022,
-0.005239247,
-0.047470752,
-0.012648283,
0.010220501,
-0.0339228,
-0.0057353876,
0.008593159,
-0.011867688,
0.06382355,
0.018099217,
-0.018654894,
-0.016207267,
0.016498335,
0.0061058393,
-0.03230869,
0.043395784,
-0.015122372,
-0.023444306,
0.03932081,
-0.008057327,
0.031620707,
-0.03106503,
-0.030191822,
0.028418945,
-0.028074954,
0.0011932186,
-0.0040518166,
-0.012205063,
0.009777281,
-0.0048423344,
0.010921713,
-0.006466368,
-0.050487287,
-0.010782793,
0.026579916,
-0.009797127,
0.0045314194,
-0.029980134,
-0.0042535802,
0.024224902,
-0.031541325,
-0.025680248,
-0.0067342846,
-0.0013040234,
-0.005067251,
-0.02762512,
0.008751924,
0.026593147,
-0.007726566,
0.01819183,
-0.001357772,
-0.014659307,
-0.009565595,
-0.012813663,
-0.016154345,
0.00462734,
-0.014804841
] |
BACKGROUND More than 80% of deaths from cardiovascular disease are estimated to occur in low-income and middle-income countries, but the reasons are unknown. METHODS We enrolled 156,424 persons from 628 urban and rural communities in 17 countries (3 high-income, 10 middle-income, and 4 low-income countries) and assessed their cardiovascular risk using the INTERHEART Risk Score, a validated score for quantifying risk-factor burden without the use of laboratory testing (with higher scores indicating greater risk-factor burden). Participants were followed for incident cardiovascular disease and death for a mean of 4.1 years. RESULTS The mean INTERHEART | [
-0.014936869,
-0.007139718,
0.017776977,
-0.053488716,
-0.004513275,
0.0137534905,
-0.015620599,
0.0032707273,
-0.021432303,
0.00016528266,
-0.0020561204,
0.01873683,
-0.02819071,
-0.01589672,
-0.010630686,
0.021116735,
0.028769251,
0.00066975947,
0.021195628,
-0.0040234877,
-0.030241901,
0.027112521,
-0.012346584,
-0.0003708331,
-0.005206866,
0.030399684,
0.033555362,
-0.016054504,
0.012215098,
-0.03960374,
0.0016772749,
-0.002458798,
-0.018697383,
-0.025061332,
-0.029821143,
0.0161071,
-0.0077708536,
-0.0035008288,
0.010571516,
-0.020617086,
0.013898126,
-0.008842468,
-0.017198438,
-0.0031638944,
-0.019749276,
0.0055257212,
0.0053547886,
-0.01312893,
-0.018000506,
0.03794701,
0.009105442,
0.02264198,
-0.0020988537,
0.0082836505,
0.0029206444,
-0.010505773,
-0.010564942,
0.021563789,
0.000710849,
-0.02790144,
0.0028286038,
-0.027769953,
-0.028295899,
0.009131739,
-0.028953332,
-0.008106144,
-0.009368415,
0.03571174,
0.020551344,
0.031583063,
0.021392858,
0.050254147,
-0.0023749752,
0.026297305,
0.019486303,
-0.0010264167,
-0.009828618,
0.0030209029,
0.002023249,
-0.0023716881,
0.012274267,
-0.014621302,
-0.0165936,
0.00931582,
0.010545219,
-0.0042601633,
-0.006107549,
0.03045228,
-0.0010157333,
-0.0044902647,
0.019367965,
0.0039182985,
-0.012478071,
0.0067912787,
-0.020104289,
-0.019525748,
-0.0034778186,
0.015738936,
0.0014940156,
-0.029084818,
-0.024430197,
-0.017579747,
-0.0027316324,
-0.009782597,
-0.030715251,
-0.006275194,
-0.022273816,
0.0015260654,
0.014765937,
-0.011603686,
0.008927935,
0.032845333,
0.0041845585,
-0.003711207,
0.0018391678,
-0.035869524,
0.008178461,
-0.004355491,
0.0180531,
-0.010696429,
0.004917596,
0.008987104,
0.02995263,
-0.01463445,
-0.008592645,
0.008165313,
-0.02556098,
-0.01209676,
0.007113421,
-0.01502891,
-0.008901638,
0.00094012864,
-0.0214586,
0.006074677,
-0.030399684,
0.017619194,
-0.017014356,
0.011597111,
-0.018723682,
-0.04107639,
-0.0043028966,
0.005118113,
-0.00031721123,
-0.0258634,
-0.0019328519,
0.03179344,
0.03366055,
0.030583765,
-0.021905655,
-0.007797151,
-0.00809957,
-0.015370774,
0.037499957,
-0.018776275,
-0.008027252,
-0.0051575587,
-0.0029978927,
0.020603938,
-0.0013123999,
0.0023338858,
-0.0020939228,
0.0005189609,
-0.0069030426,
0.002902565,
0.002651097,
-0.0005469018,
-0.00029235205,
-0.0035632849,
0.0052693225,
0.0022352708,
0.00028228512,
0.051384933,
-0.032240495,
0.023404602,
0.023509791,
0.000530055,
0.010065293,
0.006551316,
-0.03768404,
-0.031477872,
-0.024035737,
0.024101479,
0.016948612,
0.0036027308,
-0.010643834,
0.01306976,
0.0341339,
-0.005104964,
0.011097463,
-0.013444497,
-0.027585873,
0.005690079,
-0.0011439327,
-0.013727193,
-0.65217316,
-0.0035402747,
-0.00867811,
0.016698789,
-0.0009992976,
0.01302374,
0.018907761,
0.015160396,
-0.011209226,
0.03394982,
-0.01873683,
0.02205029,
-0.006837299,
-0.02282606,
-0.020669682,
-0.032634955,
0.003165538,
-0.014713342,
-0.013148652,
0.0017175428,
0.0015285308,
0.03132009,
-0.00984834,
0.020301519,
-0.021261372,
0.01990706,
0.014660748,
-0.04730885,
-0.013924423,
0.0049471804,
0.016725086,
0.023562385,
0.016448963,
0.029742252,
0.042286064,
-0.03287163,
-0.01775068,
0.020275222,
0.012754193,
0.026178967,
-0.029242603,
-0.014345179,
0.0204856,
-0.011636557,
-0.008691259,
0.027691063,
0.0016789185,
-0.0007675526,
0.015581153,
-0.021721574,
-0.010203354,
-0.016777681,
-0.023444047,
-0.00702138,
0.0013617073,
0.00018551927,
0.012898828,
-0.017961059,
-0.005160846,
0.00019589438,
-0.022839209,
0.004247015,
-0.0072646304,
-0.0048847245,
-0.011544516,
0.0029436545,
0.0070608263,
0.01717214,
0.0054534036,
-0.015594302,
0.0056079,
-0.00036590235,
-0.0019065546,
-0.009460456,
0.055382125,
0.018973505,
0.03894631,
0.0008628803,
-0.016225437,
0.005880735,
0.013194673,
0.007961509,
0.0049899137,
0.005404096,
-0.009414435,
0.0054468294,
0.007113421,
0.0037572274,
-0.011794341,
-0.00196408,
0.00887534,
0.011715449,
0.008763577,
-0.0199991,
0.017119545,
0.02379906,
-0.015633747,
0.004434383,
0.025915993,
-0.004440957,
-0.01755345,
-0.0046743457,
-0.00045979195,
0.017408816,
0.0052364506,
0.0032181325,
-0.03179344,
-0.008401989,
0.03978782,
-0.04381131,
-0.010144185,
-0.009677408,
-0.009598516,
-0.00086452387,
0.0008752072,
-0.019381113,
0.012510942,
-0.012826511,
0.010722726,
-0.0143188825,
0.008395415,
0.01668564,
0.018460708,
-0.018184585,
-0.003408788,
0.02379906,
-0.0056539206,
0.012017868,
0.004822268,
-0.027691063,
0.016606748,
-0.0017208299,
0.03689512,
-0.0051575587,
0.029584467,
0.0014093712,
0.026981035,
0.0014636094,
-0.015686342,
-0.011846935,
-0.008855618,
-0.011202652,
0.01698806,
-0.02107729,
-0.0020906357,
-0.01542337,
-0.011327564,
0.0066795154,
0.0041977074,
-0.007376394,
-0.0056177615,
-0.026376197,
0.007843171,
-0.008355969,
-0.010400584,
-0.0070608263,
0.005298907,
-0.016619897,
-0.008066698,
-0.029242603,
0.009657685,
0.0067978534,
-0.021971397,
0.0051312614,
0.012103334,
-0.0015515409,
-0.020853763,
0.0058511505,
-0.0037177815,
-0.018710531,
-0.0086846845,
-0.010420307,
0.007928638,
0.017882166,
-0.020735424,
0.029637063,
-0.020814316,
-0.008040401,
-0.032135308,
-0.024009438,
0.02224752,
-0.02897963,
-0.023299411,
-0.007580198,
0.024206668,
-0.00902655,
0.010104739,
-0.0037736632,
-0.005384373,
0.0253769,
0.008803023,
-0.00010847638,
-0.02594229,
0.034028713,
0.004036636,
0.025797656,
-0.0039248727,
-0.0022434888,
-0.00080823124,
-0.005785407,
0.029794846,
0.014687045,
0.013990166,
-0.0058281403,
0.003546849,
-0.008092996,
0.010545219,
0.00280395,
0.035475064,
0.015844125,
0.026665468,
0.0057130894,
0.005505998,
-0.0053120553,
-0.026744358,
0.013714044,
0.016475262,
-0.0032888066,
-0.010558368,
0.003173756,
-0.008546624,
-0.012392605,
0.0239174,
-0.017382517,
0.012287416,
-0.00794836,
-0.005519147,
0.018039951,
0.014332031,
-0.015883572,
-0.008612367,
-0.0034416597,
0.020498749,
0.02009114,
0.0007839884,
0.0023108756,
-0.01273447,
-0.022457898,
0.018894613,
0.031188603,
0.012392605,
0.0013880046,
0.01676453,
-0.01765864,
0.015528559,
-0.01229399,
0.02166898,
0.03034709,
0.006146995,
0.030688955,
0.0071857385,
0.017093249,
-0.002795732,
0.005670356,
-0.010900233,
-0.019867614,
0.00044253434,
0.010131037,
0.030662658,
0.024035737,
0.031556766,
0.012280841,
-0.004174697,
0.0020709126,
0.0045461464,
-0.010229652,
-0.027296603,
0.0025935716,
0.007119995,
-0.028164413,
-0.030084116,
0.003255935,
-0.0022911527,
-0.042417552,
0.009296097,
0.01366145,
0.0068964683,
0.00029954273,
0.03373944,
0.010229652,
-0.018355519,
-0.010854213,
0.012668726,
0.017408816,
-0.020722276,
-0.0044705416,
-0.001924634,
-0.005095103,
-0.018960357,
0.03431798,
0.01911814,
-0.0045494335,
0.0015170258,
-0.005601326,
0.008658388,
-0.0068635964,
0.031188603,
-0.012300564,
0.00023277223,
0.010571516,
0.008191611,
-0.024601128,
0.012865956,
-0.023391452,
0.023628129,
0.017395668,
0.006360661,
0.025508385,
0.0032296376,
0.023680722,
-0.0059596268,
-0.012412327,
-0.001978872,
0.013214395,
0.028637765,
0.016698789,
-0.018066248,
0.0016879583,
-0.0045921667,
0.0015589371,
0.0074618603,
-0.02312848,
-0.02458798,
-0.037973307,
0.061272718,
-0.0119849965,
-0.017027505,
0.0077314074,
-0.003428511,
-0.011840361,
0.0044869776,
-0.031872332,
0.009723429,
0.030715251,
0.017908465,
-0.0073040766,
0.018105695,
0.00653488,
0.009677408,
0.026297305,
-0.0025048184,
-0.013622004,
0.00008752072,
-0.00834282,
-0.008500604,
-0.009204057,
0.018460708,
0.044915795,
0.015383923,
-0.024140926,
0.022234371,
0.0214586,
0.014147949,
-0.013674598,
0.0005464909,
0.022865506,
-0.0059168935,
0.014687045,
-0.017408816,
0.017579747,
0.01297772,
-0.00004139771,
0.026744358,
-0.016120248,
0.021221925,
0.006436265,
-0.0021448738,
0.01882887,
0.006656505,
-0.009355266,
0.006229174,
0.029190008,
0.029084818,
-0.024916695,
0.021432303,
-0.0059201806,
-0.024311857,
-0.028374791,
0.0092500765,
-0.024232967,
0.0005941547,
-0.009730003,
-0.018855168,
-0.028453683,
-0.023536088,
-0.014121653,
0.01844756,
0.004066221,
-0.011301267,
-0.009033124,
-0.023259966,
-0.015134099,
-0.016856572,
-0.0043817884,
0.010380861,
-0.026100075,
-0.0020988537,
0.003629028,
-0.0018523164,
0.0124517735,
0.003346332,
-0.0063376506,
0.010137611,
-0.0071594412,
-0.0053284913,
0.007895766,
0.008855618,
-0.029900035,
-0.004532998,
0.008033827,
-0.037631445,
-0.02478521,
0.0151209505,
0.026954737,
-0.016080802,
-0.0054928493,
0.022457898,
-0.0032000532,
-0.0038558424,
-0.0015687986,
0.008947657,
-0.006745259,
-0.010006124,
-0.00882932,
0.013345882,
-0.027086224,
-0.01825033,
-0.009703705,
0.024509087,
-0.02107729,
-0.018815722,
-0.011597111,
0.01404276,
-0.020327816,
0.018894613,
-0.019828167,
0.024180371,
0.007422414,
0.015107801,
0.0026724637,
0.013076334,
0.02644194,
0.018263478,
-0.014568707,
-0.009210631,
0.014502963,
0.01639637,
0.017592898,
-0.023286263,
0.023036439,
-0.004112241,
-0.009171185,
-0.049780797,
-0.006850448,
0.0037605145,
0.022563087,
-0.0011258534,
-0.024574831,
-0.013608855,
-0.010354564,
0.016738234,
-0.019525748,
-0.02595544,
-0.0004552721,
-0.01629118,
-0.01234001,
-0.021406006,
-0.007494732,
0.037710335,
-0.029032225,
0.0070871236,
0.0019460005,
-0.02233956,
0.0059136064,
-0.01863164,
-0.00008007324,
-0.018026803,
-0.011393307,
-0.024535386,
-0.0100192735,
-0.015528559,
-0.018460708,
0.017343072,
0.018868316,
0.0129514225,
0.0032592223,
-0.0010379218,
0.0040070517,
0.007054252,
0.003131023,
0.011163206,
-0.003035695,
-0.0012129631,
0.021050991,
0.014292585,
0.025219114,
-0.04233866,
-0.02916371,
-0.004214143,
-0.009388138,
-0.0037769503,
-0.011156632,
-0.021761019,
-0.035212092,
0.0010165552,
-0.0076459413,
-0.01302374,
0.011110611,
-0.05248942,
-0.01395072,
0.03279274,
-0.0023125191,
0.019630939,
0.011656281,
-0.002407847,
-0.016672492,
0.024942994,
-0.00946703,
-0.012859382,
-0.0031901917,
-0.01873683,
-0.010433456,
0.026981035,
0.016948612,
-0.010407158,
0.021984547,
0.0062061637,
-0.010492625,
0.008448009,
0.016054504,
-0.024338156,
0.0045757308,
0.016803978,
-0.007974657,
0.013253842,
-0.010893659,
-0.010768746,
-0.00487815,
-0.009394712,
0.01019678,
-0.005502711,
0.004253589,
-0.028532576,
0.005078667,
-0.010111313,
0.0055322954,
0.0120507395,
-0.018907761,
0.04323277,
0.003295381,
-0.004450819,
-0.023470344,
0.0185396,
0.01629118,
0.00483213,
0.039445955,
0.01794791,
-0.022405304,
-0.011386733,
0.012346584,
0.022576235,
-0.021774169,
-0.01715899,
0.03842036,
0.009552496,
-0.00013107563,
-0.008231056,
-0.0045067007,
-0.026573427,
0.0066597923,
0.009979827,
-0.038788524,
0.007231759,
-0.019104991,
0.000597031,
0.0390252,
-0.018408114,
0.02468002,
0.0053350655,
-0.037447363,
-0.013319585,
-0.020630235,
-0.0031967661,
-0.0028992777,
0.030320792,
0.012280841,
0.009197482,
0.00578212,
0.0005723773,
0.0024012725,
0.0069885086,
0.022707723,
-0.026468238,
0.032897927,
0.00483213,
-0.018671086,
0.015515409,
-0.0063803834,
-0.006252184,
0.009979827,
-0.024522236,
-0.019841317,
-0.022549938,
-0.0042601633,
0.032056414,
0.010223078,
-0.00966426,
0.011886382,
-0.01560745,
-0.0070082317,
-0.02165583,
-0.013911274,
0.008816171,
-0.0064198296,
-0.01735622,
-0.008461158,
0.0049307444,
0.01580468,
0.012898828,
0.0041484,
0.00036898407,
0.016422667,
-0.031030819,
0.028506279,
0.024246115,
0.019104991,
-0.024627427,
0.016067654,
-0.034765035,
-0.010479476,
0.015173545,
0.001803009,
-0.020367263,
-0.04026117,
-0.0114524765,
0.004934032,
-0.0073040766,
-0.007994381,
0.018316073,
0.005203579,
-0.008947657,
-0.015055207,
0.0065020085,
0.038315173,
-0.025495237,
0.022615682,
0.03139898,
-0.009907509,
0.024758913,
-0.034475766,
0.029873738,
0.018749978,
-0.006715674,
-0.01765864,
0.002552482,
0.04047155,
-0.02557413,
-0.001370747,
-0.025350602,
0.008842468,
-0.0161071,
0.022037141,
0.013063186,
-0.02858517,
0.018684234,
-0.0005321095,
-0.0039873286,
0.0010239513,
0.0009524555,
-0.0018605343,
0.0152524365,
0.00741584,
-0.008671536,
-0.009414435,
0.00002696501,
0.038788524,
0.0064231167,
-0.0028811984,
-0.0033381141,
-0.0014003315,
-0.06432321,
-0.014108504,
-0.007869468,
0.040839713,
-0.0074618603,
0.023312561,
0.0071923127,
0.022852357,
-0.00702138,
0.031872332,
-0.03689512,
-0.016422667,
0.014305734,
0.0028581882,
0.000008737947,
0.00014853867,
-0.015134099,
0.004552721,
0.03502801,
0.002659315,
-0.017132694,
0.016225437,
0.0066071977,
-0.014003315,
0.0153181795,
0.00534164,
-0.0005916894,
-0.015305031,
0.01385868,
-0.01989391,
0.0007490623,
-0.008336246,
-0.00037412025,
0.009046272,
-0.02761217,
-0.008237631,
0.010341415,
-0.022589386,
-0.016422667,
-0.010190206,
-0.0051904307,
-0.023549236,
-0.007718259,
-0.009256652,
-0.0029584467,
0.031083414,
0.009236928,
0.015068356,
-0.018237181,
0.010656983,
0.017277328,
-0.01940741,
-0.00009697131,
-0.008868766,
0.0010666844,
-0.014003315,
-0.0007913845,
-0.0115182195,
-0.009210631,
-0.018894613,
-0.034765035,
-0.0008279542,
0.023312561,
0.015370774,
-0.013332734,
0.019460006,
0.0072251842,
-0.012905402,
-0.015449666,
-0.022484196,
0.025613574,
-0.0069819344,
-0.006232461,
0.004036636,
0.0013534894,
-0.026915291,
-0.014608153,
-0.013937571,
0.005844576,
0.03931447,
0.20753832,
-0.009920659,
0.008908212,
0.01569949,
-0.013937571,
0.025113925,
0.024022589,
0.018947208,
-0.012787065,
0.01639637,
-0.0073698196,
0.019157587,
0.0029091393,
0.0055487314,
0.000012114993,
-0.016580451,
-0.020012248,
0.00078933005,
0.020801168,
-0.012024443,
-0.0195126,
0.00076878525,
-0.012517517,
-0.017106397,
0.010867361,
0.010249374,
-0.011820639,
0.0064066807,
0.034896523,
-0.005404096,
-0.002835178,
-0.011202652,
-0.003938021,
0.0013230832,
-0.009282948,
-0.011860085,
-0.0023667575,
-0.011071165,
0.008369117,
-0.0018753265,
-0.009125165,
0.004700643,
-0.0030570617,
-0.031004522,
0.003405501,
0.016948612,
0.0028532576,
-0.013411625,
-0.011511645,
0.0043620653,
-0.031162307,
-0.0015326397,
0.020340964,
0.0069227656,
-0.0067781303,
0.015449666,
0.022747168,
0.004700643,
-0.0016452251,
-0.007803725,
0.017698087,
-0.00012080324,
-0.011971848,
0.012806787,
-0.053830583,
0.040839713,
-0.003185261,
-0.016462112,
0.0035599975,
-0.003306886,
-0.002942011,
-0.008599219,
-0.015936166,
-0.011399882,
-0.01913129,
-0.0185396,
0.027691063,
0.01864479,
0.00942101,
0.023075884,
-0.011426179,
-0.030399684,
-0.022418452,
0.002580423,
-0.035369873,
-0.035080604,
-0.006432978,
0.012556963,
-0.04018228,
0.005676931,
-0.0022747167,
-0.0011299623,
-0.0050589438,
0.0030488437,
0.028637765,
0.002015031,
-0.007711685,
-0.008007529,
-0.0042765993,
-0.019144438,
-0.008895063,
0.05932672,
-0.009611665,
0.0037177815,
0.00071002723,
-0.018039951,
-0.016738234,
0.00013651999,
0.023851655,
-0.004049785,
-0.0086846845,
-0.034423172,
-0.008941083,
-0.019433709,
0.000024820649,
0.025994886,
0.010814766,
-0.0138849765,
-0.01395072,
-0.024469642,
-0.0025837102,
-0.015923018,
0.015239288,
0.03563285,
-0.00133541,
-0.015436518,
-0.010735875,
-0.017106397,
-0.005160846,
-0.0077314074,
0.012221673,
-0.017869018,
0.009973253,
-0.014069058,
0.00041377166,
0.025784507,
0.009914083,
-0.00015007953,
-0.0062127383,
-0.002942011,
-0.003648751,
-0.023641277,
0.01278049,
0.0026856123,
0.016054504,
-0.0035928693,
0.013227544,
0.008973955,
-0.000013000987,
0.0004807476,
-0.00556188,
0.00465791,
-0.00955907,
-0.0073040766,
0.04360093,
-0.0064132554,
-0.008664962,
-0.017790126,
-0.0046611973,
-0.006390245,
-0.019236479,
0.0137534905,
0.038578145,
-0.0059596268,
-0.015673194,
0.023299411,
-0.1667249,
0.025048183,
0.023299411,
-0.009703705,
0.004539572,
0.006350799,
0.00024222283,
0.015581153,
-0.0020051694,
-0.008822746,
0.02847998,
-0.006170005,
-0.0019591493,
-0.005670356,
0.0014890849,
-0.0014570351,
-0.02662602,
0.052173853,
0.014082206,
0.026402494,
0.03134639,
-0.006669654,
0.0056933663,
-0.009973253,
0.016475262,
-0.0040925182,
-0.015489113,
0.018224033,
-0.010584665,
-0.01116978,
-0.020958953,
0.002388124,
0.025718763,
-0.00597935,
-0.026349898,
-0.0017750681,
-0.00790234,
-0.028927036,
-0.00089328655,
0.005177282,
0.023549236,
0.01901295,
-0.018802572,
0.01116978,
-0.012346584,
0.016133396,
0.0013691034,
-0.049991176,
0.026652317,
0.01697491,
-0.009914083,
0.0020216054,
0.01619914,
-0.00558489,
0.014581855,
-0.0005559414,
-0.010071868,
0.014857977,
0.0068964683,
-0.0077445563,
-0.03920928,
-0.010676705,
0.007198887,
0.00626862,
0.010249374,
-0.022720871,
-0.0064789983,
-0.0130171655,
0.008007529,
0.015147247,
-0.019078694,
-0.012727896,
-0.0021547354,
-0.0006430513,
0.0204856,
0.01214278,
0.0024768773,
0.0071002725,
-0.011886382,
-0.00648886,
-0.0059596268,
-0.00027468355,
-0.020367263,
-0.0049866266,
-0.0074618603,
0.006626921,
0.009296097,
-0.0014241633,
0.0024785209,
-0.031241197,
0.016146544,
-0.048860393,
-0.008467732,
-0.00037021673,
-0.005788694,
0.015134099,
-0.012826511,
-0.009789172,
-0.012169078,
0.006817576,
-0.004411373,
0.007152867,
-0.027769953,
0.008375691,
0.01405591,
-0.005496137,
-0.0041221026,
-0.0012548745,
0.020051695,
-0.015620599,
-0.000010779584,
0.0017060377,
0.00041192264,
0.037210684,
-0.014950017,
0.006626921,
-0.0185396,
-0.011938976,
0.0021103588,
-0.02937409,
0.03437058,
-0.012083611,
-0.017448261,
0.031083414,
0.008862192,
-0.0015778383,
-0.10166538,
0.025639871,
0.012445199,
0.0119587,
0.006949063,
0.01189953,
-0.0077577047,
0.0063212146,
0.00063565513,
0.04751923,
-0.011722024,
-0.012543814,
-0.0067222486,
-0.002509749,
0.036474362,
-0.021590088,
-0.006363948,
-0.026113223,
-0.009920659,
0.03668474,
-0.004335768,
-0.04165493,
0.020354114,
-0.02244475,
0.0024357878,
-0.019578343,
-0.015949314,
0.0074881576,
0.0011948837,
0.016330626,
0.007987807,
0.020380411,
-0.0023158065,
0.003278945,
-0.017829573,
-0.0071594412,
0.010249374,
-0.035396174,
0.031372685,
-0.009033124,
0.021406006,
0.021971397,
0.008277076,
-0.008408563,
0.0058938833,
0.0000012487368,
-0.028690359,
0.0011373584,
-0.020577641,
-0.020275222,
-0.00058100605,
-0.017290479,
-0.01949945,
-0.0027151967,
0.009854915,
-0.020998398,
0.015475964,
0.0005164955,
-0.00010703825,
0.008520327,
0.00013641726,
-0.0006266155,
-0.032450873,
0.032766443,
0.02372017,
-0.0370792,
-0.009789172,
0.00059456564,
0.012438625,
-0.0071068467,
-0.011288118,
-0.0035994435,
-0.02595544,
0.0185396,
-0.027086224,
0.012228247,
-0.024325008,
0.006446127,
0.00085055345,
-0.017671788,
-0.017974207,
-0.008000955,
0.01322097,
-0.022563087,
-0.00931582,
0.007231759,
0.0069819344,
-0.010426882,
0.003750653,
-0.025810804,
0.015673194,
0.04651993,
0.011768044,
-0.010380861,
0.029847441,
0.024522236,
0.011150057,
-0.017842721,
-0.012530666,
0.010374286,
-0.0045757308,
-0.0071002725,
-0.05346242,
0.025994886,
0.0129317,
0.0051707076,
0.0044836905,
-0.017790126,
0.0073698196,
0.003911724,
0.01097255,
0.002077487,
-0.009171185,
0.022155479,
-0.011380158,
0.032109007,
-0.010643834,
0.0041944203,
0.012399179,
0.03266125,
0.034186497,
0.01706695,
0.00624561,
0.018276626,
-0.0033003117,
0.023075884,
0.012865956,
-0.0048748627,
-0.0062357485,
0.047677014,
-0.0165936,
-0.012392605,
0.017421965,
-0.027743656,
0.004904447,
0.01775068,
0.019039249,
-0.028427387,
-0.009690557,
0.012261118,
0.011971848,
0.014805382,
-0.0035567104,
-0.024745764,
-0.02517967,
-0.0042207176,
-0.0027825835,
0.0119192535,
-0.008835894,
0.0073829684,
-0.0010083372,
-0.0062193125,
0.020748572,
0.0075473264,
-0.024114627,
-0.032056414,
-0.03681623,
0.01463445,
0.018394964,
-0.0009803964,
-0.0053679375,
-0.035054307,
0.040918607,
0.0020840615,
0.005006349,
0.02059079,
0.012898828,
-0.027954035,
-0.0005505998,
0.011952125,
0.009598516,
-0.030583765,
-0.015278734,
-0.007994381,
-0.021603236,
0.020314667,
-0.012162504,
0.00020822123,
-0.0061206976,
0.021616384,
-0.0057262382,
0.004598741,
0.028558873,
-0.0038295449,
-0.025784507,
0.025837101,
0.004247015,
0.011189503,
-0.008691259,
0.031872332,
-0.0050523696,
0.00092040567,
-0.011991571,
0.017395668,
-0.009138313,
0.009473604,
0.0055520185,
0.019736128,
0.0027250582,
-0.0019312083,
0.021313965,
0.02379906,
-0.0026741072,
0.01019678,
-0.03681623,
-0.028032927,
-0.0041484,
0.0029765263,
0.0032230634,
-0.028506279,
-0.03941966,
0.007310651,
0.039235577,
0.040734526,
-0.02224752,
0.004713792,
0.012175652,
-0.018999802,
0.0008020678,
0.016435815,
-0.0106175365,
0.024259264,
-0.0028483267,
0.0143846255,
-0.002611651,
0.012175652,
0.009927233,
0.01589672,
0.011616834,
-0.0028598318,
0.017803276,
-0.0048518525,
0.010650408,
0.00079836976,
-0.029978927,
-0.00966426,
-0.00020709127,
-0.029926332,
0.019933356,
-0.007093698,
0.0020972101,
0.06684775,
-0.015094653,
0.001134893,
-0.0026560277,
0.0067781303,
0.019933356,
0.0048288424,
-0.005601326,
-0.010998848,
-0.040077094,
-0.0116497055,
-0.02166898,
-0.0021941813,
-0.052410528,
-0.025140224,
0.026349898,
0.0031441716,
0.029295197,
-0.009171185,
-0.032345686,
0.009532773,
-0.01004557,
0.039077796,
0.006531593,
-0.01913129,
-0.01156424,
0.024640575,
0.0046842075,
-0.00073509186,
-0.018197734,
0.004158261,
0.005499424,
-0.013937571,
0.009348691,
0.01679083,
0.0105517935,
0.0069622113,
-0.025232263,
-0.00063935324,
-0.011222375,
-0.00980232,
0.014410923,
-0.035869524,
-0.038841117,
0.0027119096,
-0.0003825436,
-0.023930548,
-0.015949314,
-0.047650717
] |
Thyroid cancers are infiltrated with tumor-associated macrophages (TAMs), yet their role in cancer progression is not known. The objectives of this study were to characterize the density of TAMs in well-differentiated (WDTC), poorly differentiated (PDTC), and anaplastic thyroid cancers (ATC) and to correlate TAM density with clinicopathologic parameters. Immunohistochemistry was performed on tissue microarray sections from WDTC (n=33), PDTC (n=37), and ATC (n=20) using macrophage-specific markers. Electronic medical records were used to gather clinical and path | [
-0.025659254,
0.0002211646,
-0.0017310343,
-0.024740474,
-0.0213583,
0.00924106,
-0.024101324,
-0.0010868898,
-0.031105354,
-0.00896809,
0.024820369,
0.01569915,
0.016484773,
0.007949443,
-0.0092676915,
0.021065356,
0.030918935,
-0.017443499,
-0.03328912,
-0.013661855,
-0.031371668,
0.017070662,
-0.010945463,
-0.00397805,
0.0035785805,
0.036671296,
0.020692518,
-0.04127851,
-0.015006736,
-0.012230423,
0.01245679,
-0.021677876,
-0.010545993,
-0.0037949597,
-0.007396843,
-0.011990742,
0.02383501,
-0.0010419495,
0.03885506,
-0.0017942836,
-0.012643208,
-0.00029689734,
0.017297028,
-0.004017997,
0.010292997,
0.0011776027,
-0.0017976125,
-0.0058921743,
-0.004500689,
0.015033367,
0.009900184,
-0.0039281165,
-0.01836228,
-0.009873553,
-0.027989494,
0.009214429,
0.010625888,
0.0379496,
-0.008002705,
-0.01600541,
-0.014727107,
-0.018828327,
-0.010605914,
0.015619256,
0.0010469429,
-0.00033164286,
-0.010213102,
0.024567371,
0.024101324,
0.013888221,
0.05238376,
0.014913526,
0.0034587397,
0.000121297235,
0.010153182,
-0.017976126,
-0.015459468,
-0.009008036,
-0.0045639384,
-0.0039913654,
0.0054694028,
-0.018801695,
0.0016086968,
0.018415542,
0.009833606,
0.0008068451,
-0.004041299,
0.004204416,
0.008681803,
-0.0050166706,
0.02414127,
0.023635276,
0.0066078906,
0.017510077,
0.0039181295,
0.009986737,
-0.01612525,
0.035419624,
0.0054327846,
-0.021917557,
-0.013888221,
0.0072903177,
-0.0079294685,
-0.019787055,
-0.00908793,
-0.007476737,
0.0026980832,
0.032117344,
0.016857611,
-0.03222387,
-0.014008062,
0.0237418,
-0.009360901,
-0.041145355,
0.014247744,
-0.003561936,
0.006637851,
-0.007962758,
-0.004327586,
-0.015978778,
0.0049334476,
0.025752464,
0.03392827,
-0.012643208,
0.027882967,
-0.0055126785,
-0.020093314,
0.01236358,
-0.0059753973,
0.0077430494,
0.018828327,
0.005725729,
0.035179943,
0.006924137,
-0.0097603705,
-0.0026265117,
-0.038535487,
-0.0014297678,
-0.01499342,
-0.019866947,
0.0025050063,
0.034008168,
0.0033388988,
-0.02282302,
-0.017643234,
0.027749812,
0.03986705,
0.01328236,
-0.0055559543,
0.020186523,
-0.028974852,
-0.015326312,
-0.0028262464,
-0.013295675,
-0.026910925,
-0.00095123664,
0.0034620685,
0.01129167,
-0.02659135,
-0.012330291,
-0.0038582091,
0.015592624,
0.0104661,
0.017310344,
0.032357026,
0.027510129,
0.00927435,
0.018735118,
-0.009687134,
-0.002628176,
0.02340891,
0.012123898,
-0.01181098,
0.012290344,
-0.0072237393,
-0.010745728,
-0.0052230633,
0.01900143,
-0.035845727,
-0.038029492,
0.005342904,
0.009846922,
0.014127903,
-0.009300981,
-0.017629918,
-0.00044773868,
0.017083976,
0.015712466,
-0.011617904,
-0.0185487,
0.0075632883,
0.045299836,
-0.0066045616,
-0.0014888559,
-0.64085555,
-0.005985384,
0.017922863,
-0.016830979,
0.009247717,
0.013535357,
0.010119893,
-0.013781697,
-0.034993526,
0.010665835,
-0.0034454241,
0.015685834,
0.012996073,
-0.030679254,
0.01364854,
-0.04665803,
-0.020865621,
-0.0050998935,
-0.007423474,
0.0034687265,
-0.021025408,
0.00335055,
-0.000013406673,
-0.0007781332,
-0.0037716574,
-0.0020572676,
0.013355595,
0.007663156,
0.015379574,
0.04354217,
-0.029454214,
0.019720476,
0.0077230763,
-0.018229123,
0.04231713,
0.0056258617,
-0.0054627447,
0.016098619,
0.02579241,
0.017070662,
0.0023585341,
-0.016591297,
0.00526301,
-0.0033588724,
-0.024527425,
0.041784506,
-0.024074692,
0.009114562,
0.015832307,
-0.033715222,
-0.009773686,
0.011358248,
-0.028282437,
0.0004955918,
0.03824254,
-0.008402174,
0.009307639,
-0.0105925985,
-0.009787002,
0.015166524,
0.0144341625,
0.027856337,
-0.0092676915,
-0.00042568464,
-0.019174533,
0.0129761,
0.000828483,
0.01104533,
-0.017842969,
-0.018562013,
0.011824296,
0.023821695,
-0.014833633,
0.0028878313,
0.024434214,
0.0313983,
0.0146072665,
-0.012323633,
0.003372188,
0.004873527,
0.005392838,
-0.0041078776,
-0.019387584,
0.0015945489,
0.01266984,
-0.003528647,
-0.015339627,
0.01848212,
0.010339601,
0.010958779,
-0.0019807026,
0.014873579,
-0.020466153,
-0.049587473,
-0.014127903,
0.0025632624,
-0.010326286,
0.004840238,
0.013755064,
-0.019187849,
-0.020466153,
0.015965462,
0.0000125289325,
-0.00924106,
0.04335575,
0.004144496,
-0.04103883,
-0.011751059,
0.030013472,
-0.015752412,
0.0099135,
0.01312923,
-0.0056990976,
-0.012543341,
-0.0009678812,
-0.0143809,
0.032383658,
0.0259522,
-0.0065313256,
-0.018628592,
0.02814928,
0.0071038986,
0.0318244,
0.00816915,
0.0048568826,
0.015978778,
0.0034321083,
-0.02237029,
-0.001343216,
-0.0079561,
-0.004697095,
0.0034653975,
0.01765655,
-0.025259785,
0.021771085,
0.008242386,
0.006168474,
-0.012137214,
-0.011877558,
-0.037976228,
-0.010173155,
-0.009047983,
0.015526046,
-0.0009720423,
-0.00826236,
-0.020332996,
-0.015526046,
-0.010965437,
0.0073302644,
0.0134421475,
-0.005103222,
0.008115888,
-0.0122637125,
0.0012525031,
0.035046786,
-0.0104261525,
-0.006617877,
-0.026484825,
0.0055559543,
-0.006970742,
-0.025392942,
0.021091986,
-0.004810278,
0.015246417,
-0.0050133415,
-0.01386159,
-0.018415542,
0.018335648,
-0.011378221,
-0.023195859,
-0.010652519,
-0.01878838,
0.0064514317,
0.010406179,
0.0029843696,
-0.0032639983,
0.007390185,
-0.021078672,
-0.010266365,
-0.019787055,
0.004530649,
0.007842917,
0.022157239,
-0.016444826,
0.03387501,
0.009873553,
0.024527425,
-0.026737822,
0.008548646,
0.039946947,
-0.011478089,
0.0003536969,
0.008495384,
0.010565967,
0.01196411,
-0.030625992,
0.032889653,
0.026551403,
0.01288289,
0.021411562,
-0.016937505,
-0.021571351,
0.01909464,
-0.0033555434,
0.013781697,
-0.013289018,
0.002411797,
-0.019574003,
0.027616655,
0.011471431,
0.005499363,
-0.0058921743,
0.005306286,
0.018095966,
-0.01805602,
0.029187901,
0.0072170813,
-0.001047775,
-0.011304986,
-0.014713791,
-0.00462053,
0.006857559,
0.02472716,
-0.009607241,
-0.0016511404,
-0.020918883,
0.047510233,
0.0069907154,
-0.0042144028,
-0.0058488986,
0.0053994954,
0.0029227848,
0.00085095316,
0.013115914,
0.026125303,
-0.011950795,
-0.014966789,
-0.0019740448,
0.038428962,
-0.0036451588,
0.010918831,
0.0075100255,
0.00559923,
-0.012330291,
-0.013888221,
-0.0047170683,
0.02567257,
0.024673896,
-0.023675224,
-0.011817638,
0.0059753973,
0.0038781827,
0.006148501,
-0.011165171,
-0.012030688,
-0.009560635,
0.00593545,
-0.0014281033,
0.040985566,
0.006857559,
0.015805675,
-0.0063815247,
-0.0009004707,
-0.016870927,
-0.0067377184,
0.012237081,
0.022050714,
-0.016071988,
0.011538009,
-0.0003711737,
-0.016657876,
0.017097292,
0.03778981,
-0.05280986,
-0.003981379,
0.005948766,
0.019134587,
0.0007306962,
0.00416114,
0.022237133,
-0.024660582,
-0.039068114,
0.025446204,
0.041837767,
-0.008768355,
-0.012470105,
-0.03283639,
-0.00510988,
-0.0020922213,
0.007969416,
0.01989358,
0.0061651454,
0.010865569,
0.0023252452,
-0.0033155964,
-0.005489376,
0.017177187,
0.0044207955,
-0.0014322645,
0.013635224,
0.009580609,
-0.015579308,
-0.011471431,
-0.005802294,
0.008282334,
0.0009553978,
-0.022996126,
-0.013448805,
-0.017297028,
0.0006632857,
-0.0037550128,
-0.028655276,
-0.0001802814,
0.013009389,
0.010246391,
-0.011511378,
-0.0025449533,
0.022024082,
0.027177239,
0.022157239,
0.014354269,
-0.030199891,
-0.0043042833,
-0.017576655,
0.03304944,
0.031078724,
-0.005858885,
-0.013289018,
0.017057346,
0.008009363,
0.0023019428,
-0.0092610335,
0.020559361,
-0.011944137,
0.004134509,
0.0036418298,
0.025925567,
0.008495384,
-0.0043708617,
0.034381006,
-0.019480795,
-0.008508699,
-0.021318354,
-0.0055892435,
-0.0067543625,
-0.036458246,
0.02371517,
0.015446153,
0.03925453,
-0.006704429,
0.019880263,
0.017869601,
0.012536683,
-0.013149203,
-0.02937432,
0.020399574,
-0.005602559,
0.011924163,
0.007263686,
-0.021651244,
0.01165785,
0.013488752,
-0.012716444,
-0.012969442,
-0.0013315649,
0.028628644,
0.020599307,
-0.0042543495,
0.0054261265,
0.0033588724,
0.033582065,
0.01309594,
0.025166575,
-0.02105204,
0.025592677,
-0.0065046945,
-0.006324933,
-0.025992146,
0.008535331,
0.0028079373,
0.0038715247,
-0.0014605602,
-0.0018292372,
-0.002408468,
0.0049833814,
-0.013142545,
0.016804349,
-0.02001342,
-0.02074578,
-0.016418194,
-0.022143923,
-0.013289018,
-0.0019790384,
-0.0069774,
-0.009940132,
-0.018735118,
-0.030279785,
0.0070706094,
0.002018985,
-0.0010527684,
0.006228395,
-0.01165785,
0.005685782,
0.035446256,
-0.014114588,
0.0016111934,
-0.0028112663,
-0.021930873,
-0.0118709,
-0.012390211,
0.0069108214,
-0.014207797,
-0.0014247744,
0.021131935,
-0.0030859015,
-0.0030759147,
0.007916153,
-0.0056125456,
-0.0077164182,
0.010392863,
0.015845621,
0.00578232,
-0.01282297,
-0.0006944943,
-0.01156464,
-0.023209175,
-0.014314322,
0.007277002,
0.0037683286,
-0.015139893,
-0.004690437,
0.012070635,
-0.0096005825,
-0.02053273,
0.023661908,
-0.010126551,
-0.008748381,
0.0057357154,
0.011451458,
0.026964188,
-0.011544667,
0.0056724665,
-0.0051664715,
0.011990742,
-0.0041478244,
0.0003295623,
0.017083976,
0.000062053005,
-0.032330394,
-0.0038415645,
-0.017310344,
-0.004970066,
-0.0028195886,
-0.03595225,
0.00443744,
-0.0029327716,
0.010486073,
-0.022942862,
-0.0047603445,
-0.0018608619,
-0.018255753,
-0.0055459677,
0.00017622429,
-0.032889653,
-0.010692466,
0.020213155,
-0.022769758,
-0.01416785,
0.0081025725,
-0.030546097,
-0.01499342,
0.031105354,
0.022996126,
0.033102702,
0.0016594627,
-0.013488752,
-0.012876232,
-0.0014971782,
-0.020599307,
-0.02689761,
-0.0069108214,
0.0029127982,
0.021797717,
0.01970716,
0.0209322,
0.0048369095,
0.028096018,
0.0194009,
0.00017050272,
-0.004767002,
0.014301007,
0.02772318,
-0.0022470157,
0.0022653246,
0.020253101,
-0.005945437,
0.005369535,
-0.011404853,
0.016591297,
0.0055526253,
-0.015392889,
-0.00333557,
0.012376895,
-0.040985566,
-0.03406143,
-0.0014414189,
-0.011611246,
-0.00073818624,
-0.034167953,
-0.0009662167,
0.010785676,
0.019933525,
0.010612572,
0.00047603445,
0.018149229,
0.006328262,
0.010246391,
-0.018641908,
-0.009780344,
-0.005006684,
-0.016551351,
-0.014540688,
-0.000053886764,
0.026551403,
0.008302307,
0.009127877,
0.018149229,
-0.015193155,
0.02894822,
0.013289018,
-0.023115966,
-0.015739096,
-0.011624561,
-0.034780473,
-0.04868201,
-0.014261059,
-0.03611204,
-0.020692518,
0.009773686,
0.0030343034,
-0.0209322,
-0.0092676915,
-0.024367636,
-0.016085302,
0.032703232,
-0.010339601,
0.031265143,
-0.03653814,
0.012982757,
0.01881501,
-0.0065313256,
-0.017709812,
-0.004397493,
-0.02683103,
0.008615225,
0.02472716,
0.021344984,
-0.009387532,
0.007683129,
-0.0048835143,
-0.0023585341,
0.012856259,
-0.008828275,
0.023262437,
-0.009141193,
0.002901147,
-0.013109256,
-0.0054727313,
-0.059228003,
0.005266339,
-0.006141843,
-0.001135159,
0.012376895,
-0.0033888326,
-0.014647214,
0.024407584,
-0.0073835272,
0.012969442,
0.0068442435,
-0.011338275,
0.0065812594,
-0.040532835,
-0.016551351,
0.0072303973,
-0.010945463,
0.024354322,
-0.001653637,
0.012483421,
0.011817638,
-0.005036644,
-0.009707108,
0.0025932225,
-0.021531403,
0.038482223,
0.008395516,
0.011824296,
0.017949494,
-0.0018009414,
0.008801644,
-0.0072969752,
-0.008335596,
-0.007822944,
-0.026524771,
0.007842917,
0.031424932,
0.0069774,
-0.005419469,
-0.0009678812,
-0.0313983,
0.004201087,
-0.014327638,
-0.037470236,
0.0104661,
-0.039520845,
-0.008994721,
0.018508751,
-0.0055359807,
0.026151933,
0.027190555,
-0.000042547657,
-0.02683103,
0.037843075,
-0.0067343893,
0.009787002,
0.010206444,
0.02298281,
-0.021624614,
-0.0097603705,
0.004434111,
-0.04681782,
-0.0075233416,
-0.020332996,
-0.05768339,
-0.024780422,
-0.012629893,
0.009014694,
0.013415515,
-0.0079561,
0.021291722,
0.01817586,
0.015938831,
0.017443499,
-0.02298281,
0.020093314,
-0.033102702,
0.0038215911,
0.005369535,
0.0028711867,
-0.012257054,
-0.0014555668,
-0.024647266,
0.030359678,
-0.020279733,
-0.0014713792,
-0.023954852,
0.022929547,
-0.02597883,
0.023502119,
-0.010992068,
-0.0035852382,
-0.0034454241,
0.014221112,
0.00019900652,
-0.013901537,
-0.0076698135,
-0.0047237263,
-0.02218387,
-0.0055426387,
-0.03283639,
-0.009527346,
0.010292997,
-0.012037346,
-0.027936231,
0.0052463654,
-0.04476721,
0.021424878,
-0.0012932824,
-0.010206444,
-0.010865569,
-0.0037416972,
-0.04250355,
-0.035020154,
-0.0015754077,
0.009500715,
-0.0006974071,
0.001726041,
-0.017057346,
0.03675119,
0.006431458,
-0.0066012326,
-0.003478713,
-0.025073366,
0.010852253,
-0.009187797,
0.030759148,
0.0067210738,
-0.029427582,
-0.018415542,
0.0322505,
-0.0074833944,
-0.035898987,
0.0062916437,
-0.026484825,
0.0065812594,
-0.0283357,
-0.00028399783,
-0.02996021,
0.006624535,
0.021118619,
-0.0083822,
0.015672518,
0.016231775,
0.007277002,
0.010579282,
-0.0007714754,
0.0028745157,
0.011032015,
0.0076764715,
-0.010073288,
-0.044207953,
0.027510129,
-0.027230501,
0.0233157,
0.020239785,
-0.00038220073,
0.015126577,
0.019494109,
-0.018508751,
-0.013928168,
-0.009314296,
-0.023262437,
0.004846896,
-0.006138514,
-0.003164131,
-0.02114525,
0.010292997,
0.029454214,
-0.03286302,
-0.009008036,
-0.016165197,
-0.009707108,
-0.027376974,
0.013901537,
0.011251723,
-0.010446127,
-0.01615188,
-0.011211776,
-0.019973474,
-0.0041777845,
-0.016937505,
0.016351616,
-0.006784323,
-0.0016394892,
-0.011165171,
-0.01645814,
0.012137214,
-0.0062949727,
-0.026511457,
-0.015352943,
0.008821617,
0.18716475,
-0.026245143,
-0.018002756,
0.0150999455,
0.013368911,
0.0059620817,
0.017709812,
0.0013016047,
-0.0075166835,
0.01735029,
0.04828254,
0.013315649,
0.010958779,
0.009860238,
0.0034321083,
-0.011478089,
-0.013375569,
-0.015659202,
-0.015526046,
-0.02227708,
-0.0045938985,
-0.005442771,
0.035632674,
0.0035386337,
0.029693896,
-0.0071305297,
-0.015952148,
0.0029610672,
0.03177114,
-0.001719383,
-0.030333048,
0.014127903,
-0.0009054641,
-0.015126577,
-0.0036451588,
-0.009360901,
-0.028282437,
0.0019590647,
0.008029336,
-0.011065304,
0.0042310474,
-0.0069108214,
-0.013755064,
0.01836228,
0.013821643,
-0.00046230268,
0.0049634078,
-0.012703129,
-0.0036817768,
-0.0043775192,
-0.02249013,
0.0021421548,
0.022503447,
-0.007576604,
-0.01765655,
-0.0013906531,
0.014340953,
0.02258334,
-0.015139893,
0.022263763,
-0.014154535,
0.004846896,
-0.026151933,
0.03778981,
-0.019627266,
0.019374268,
-0.0036917636,
-0.009573951,
-0.00046771215,
0.006614548,
0.02390159,
-0.009813633,
-0.006877532,
-0.014367585,
-0.0031225195,
-0.010446127,
0.04641835,
0.011884216,
0.002668123,
0.030519467,
-0.008275676,
-0.0129228365,
0.016657876,
-0.013515383,
-0.004041299,
-0.026631298,
0.014740423,
-0.009966763,
-0.00019110036,
-0.005106551,
-0.011145198,
-0.0068076253,
0.0037949597,
0.0029477517,
0.0279096,
0.015059998,
0.014540688,
-0.0069774,
0.012150529,
-0.02444753,
-0.0156059405,
0.06263681,
0.020705834,
0.010992068,
0.0033006163,
0.009747054,
-0.013115914,
0.0013989753,
0.012163845,
-0.016391564,
0.015592624,
-0.036671296,
0.008155835,
-0.006637851,
0.012183818,
0.027430236,
-0.0020938858,
-0.019547371,
0.0019823671,
-0.016071988,
0.014793686,
-0.021597981,
0.00191246,
0.012010715,
-0.021371616,
-0.005579257,
-0.047084134,
-0.007902837,
0.015645888,
-0.01478037,
-0.00095373334,
-0.009001378,
-0.019147903,
0.0149401575,
0.0003532808,
-0.0019906894,
0.025752464,
-0.01529968,
-0.01386159,
0.024154587,
-0.006857559,
0.009933474,
0.001641986,
0.009520689,
0.018002756,
-0.020585993,
0.0045705964,
0.004134509,
-0.028495489,
-0.034966893,
-0.02548615,
-0.017829653,
-0.01793618,
0.015246417,
0.0109321475,
-0.003528647,
-0.008468753,
-0.011358248,
-0.018442173,
-0.0011900861,
-0.024620634,
-0.007976074,
0.02310265,
0.007882864,
0.00049517566,
0.009474084,
-0.1678837,
0.02711066,
0.02625846,
-0.011331617,
0.033369016,
0.021025408,
0.015526046,
0.00093625655,
-0.015179839,
0.0016161868,
0.022463499,
0.0016702816,
-0.04066599,
0.021558035,
0.0058488986,
0.0089348005,
0.013115914,
0.031930923,
0.015512731,
0.0055492967,
0.019866947,
-0.021131935,
0.005116538,
-0.019147903,
-0.0074035004,
0.04085241,
0.00070780993,
0.009054641,
-0.008921484,
-0.0114448,
-0.020878937,
-0.011151856,
0.024820369,
0.0099135,
0.0014306,
0.02729708,
0.004504018,
-0.010898858,
-0.01588557,
-0.010292997,
0.029028114,
0.00085386593,
0.02239692,
-0.0013931497,
-0.019640582,
0.019467479,
0.0012233752,
-0.0038415645,
0.016191829,
-0.02013326,
0.019267743,
-0.008482068,
0.008195782,
0.024567371,
-0.008362227,
0.004014668,
0.011418168,
0.027856337,
0.016844295,
0.005000026,
-0.006667811,
-0.0067144157,
0.010452784,
-0.0033522146,
-0.0008829939,
-0.056777924,
-0.022410236,
-0.008282334,
-0.011225091,
0.0007723076,
-0.020492783,
0.0010128216,
0.027376974,
-0.02894822,
0.013502068,
0.022423552,
-0.014447479,
0.012623235,
-0.014886895,
0.011338275,
0.0074035004,
0.0005879691,
-0.041970924,
-0.010153182,
-0.00816915,
0.009008036,
0.0134288315,
0.013515383,
-0.01312923,
-0.00087300723,
0.0017143898,
-0.024807053,
0.002197082,
-0.031478193,
0.009081272,
0.042530183,
-0.026205197,
0.018708486,
-0.0043309145,
-0.018921537,
0.020093314,
-0.029933577,
-0.033182595,
0.025219839,
0.013941484,
0.01600541,
-0.02812265,
0.0040512863,
0.04348891,
-0.012010715,
-0.0042942967,
0.007836259,
0.0005625861,
0.0002613196,
0.008415489,
0.022516761,
0.0388018,
-0.009713765,
-0.012230423,
-0.014820317,
0.07206429,
0.010519362,
-0.0062650125,
0.020825675,
0.002138826,
-0.0033954903,
-0.12378227,
-0.0072570285,
-0.006274999,
0.005675795,
-0.02310265,
0.010998726,
-0.010652519,
0.011118567,
-0.04498026,
0.044074796,
-0.008941458,
-0.01416785,
-0.020892253,
-0.030119997,
0.024088008,
-0.00908793,
0.004320928,
-0.008402174,
-0.02053273,
0.032357026,
0.004890172,
-0.0014905204,
0.01942753,
-0.027163923,
0.0077497074,
0.0036218564,
-0.031664614,
0.034141324,
0.008275676,
0.004427453,
-0.0075100255,
0.012316975,
0.021890925,
-0.006015344,
-0.007849575,
0.015179839,
0.0015962133,
-0.016511405,
0.038668644,
0.0053329174,
-0.003711737,
0.019068008,
0.0022037397,
0.011910847,
-0.006591246,
-0.01723045,
-0.04601888,
-0.013089282,
0.005832254,
-0.016977452,
-0.014087956,
-0.020878937,
-0.016058672,
0.009560635,
0.0010469429,
-0.0064248005,
0.009300981,
0.028894957,
-0.008561962,
0.013741749,
-0.015579308,
-0.011118567,
-0.005705755,
0.033182595,
0.040213257,
-0.026857663,
0.006554628,
-0.0072503705,
0.023675224,
-0.019267743,
-0.009047983,
-0.012137214,
-0.02258334,
-0.03595225,
-0.017603287,
-0.0035519493,
-0.01447411,
-0.0050965645,
0.013542014,
-0.019334322,
-0.016484773,
-0.012277028,
0.009886869,
-0.011897532,
0.038721904,
-0.0043409015,
-0.006777665,
-0.02074578,
0.016324986,
-0.035366364,
0.013728433,
0.032996178,
-0.0016220125,
-0.018948168,
-0.020066682,
0.025406258,
0.0050166706,
0.01303602,
0.014394216,
0.020559361,
-0.03264997,
-0.027989494,
-0.056564875,
0.02916127,
-0.0021271748,
0.00027421914,
-0.004580583,
-0.022103976,
0.0008172479,
-0.009207771,
0.018641908,
0.024114639,
-0.02249013,
0.019653898,
-0.0034986867,
0.0029777118,
-0.0104661,
0.0015762399,
-0.005372864,
-0.008841591,
0.015925515,
0.021118619,
-0.0038448935,
-0.018908221,
0.005339575,
0.01848212,
-0.0029127982,
0.008335596,
-0.021424878,
0.020652572,
-0.009753712,
0.0021121947,
0.016378248,
-0.015286365,
-0.0075566303,
0.0032523472,
0.0048568826,
-0.006664482,
-0.014713791,
0.032543443,
0.018934852,
0.038455594,
-0.0053595486,
-0.048389066,
0.0062317234,
-0.0026381628,
-0.023582013,
-0.015845621,
-0.016631246,
-0.0012009051,
0.0010769031,
-0.0036085406,
0.027510129,
-0.0024367636,
0.0065246676,
-0.03864201,
-0.023155913,
-0.0007073938,
0.017909547,
-0.02475379,
-0.0021438194,
-0.010446127,
0.01129167,
0.035020154,
0.0028062728,
0.0120972665,
0.022716496,
-0.012390211,
-0.019787055,
-0.010745728,
0.012689813,
-0.025193207,
-0.00095123664,
-0.0057390444,
0.013209123,
0.0047570155,
0.0031957556,
-0.0034554107,
-0.027696548,
0.019534057,
0.0024034746,
0.008848248,
-0.01520647,
0.005492705,
-0.023914905,
0.03304944,
0.032596707,
-0.011784349,
-0.01236358,
0.030785779,
-0.0087616965,
0.00847541,
-0.009340927,
0.02720387,
0.018535383,
-0.0063881823,
-0.012190476,
0.0057224,
-0.001627838,
0.009633872,
0.028202543,
0.041198615,
0.012530025,
-0.016977452,
0.00067660137,
-0.015645888,
-0.019787055,
-0.009360901,
-0.029427582,
-0.025206523,
-0.0076232087,
0.014620582,
0.02383501,
0.011038672,
0.0035419625,
-0.0071038986,
-0.018841643,
0.024607318,
-0.014301007,
0.0053994954,
-0.014860264,
0.016684508,
0.008921484,
0.017669866,
0.0060419757,
0.023222491,
0.003828249,
0.015685834,
0.013874906,
-0.025206523,
0.035366364,
0.010359574,
0.010492731,
-0.0012383553,
-0.030892305,
0.004553952,
-0.0074434476,
-0.014048009,
0.0056891106,
0.039148007,
-0.016977452,
0.080799356,
0.0041012196,
-0.026937557,
0.0009054641,
-0.022636602,
0.003894827,
0.029400952,
-0.010752386,
0.0048835143,
-0.016910873,
-0.000068554786,
-0.011784349,
0.012589945,
-0.021344984,
-0.040293153,
0.00924106,
-0.009300981,
-0.002879509,
0.010472758,
-0.0077563655,
0.0094874,
0.0009320954,
0.0040013525,
0.030625992,
-0.022876285,
-0.004197758,
0.040612727,
0.0066911136,
-0.005073262,
-0.029480847,
0.002310265,
-0.0037982888,
-0.024900263,
-0.009520689,
0.0073568956,
-0.019440847,
-0.015059998,
-0.039334424,
0.020958832,
0.02894822,
0.0013973109,
0.024114639,
-0.015326312,
-0.009740397,
0.00033850875,
-0.012683155,
-0.010079946,
-0.03278313,
-0.0033638657
] |
OBJECTIVE T cell immunoglobulin and mucin domain (Tim) proteins are expressed by numerous immune cells, recognize phosphatidylserine on apoptotic cells, and function as costimulators or coinhibitors. Tim-1 is expressed by activated T cells but is also found on dendritic cells and B cells. Tim-4, present on macrophages and dendritic cells, plays a critical role in apoptotic cell clearance, regulates the number of phosphatidylserine-expressing activated T cells, and is genetically associated with low low-density lipoprotein and triglyceride levels. Because these functions of | [
-0.038797855,
-0.004315998,
-0.004984813,
-0.0217579,
-0.013560799,
0.0090339435,
-0.024406802,
0.0077622067,
-0.020071037,
-0.0086913,
0.03073254,
-0.00062927906,
0.0010938254,
0.01736942,
-0.027754173,
0.009936679,
0.020545468,
0.0076238313,
-0.01842371,
0.005271448,
-0.044411946,
0.0008829675,
-0.003154632,
-0.016565524,
-0.0013639871,
0.0039964165,
0.006618961,
-0.039298642,
-0.01498409,
-0.0071362224,
-0.0042731673,
-0.012684421,
-0.02117804,
0.015616664,
0.007946707,
0.0024545179,
0.020624539,
-0.0047278297,
0.02978368,
-0.0032238197,
-0.0036109416,
0.0057887086,
0.007946707,
0.0058150655,
0.008065315,
0.0020113867,
0.008994408,
0.0051561347,
-0.015629843,
0.020440038,
0.015972486,
0.0062466655,
-0.021836972,
-0.02128347,
-0.017817494,
-0.0063422103,
0.0006313382,
0.021731542,
-0.008678121,
-0.015880236,
0.0012873864,
-0.020532288,
-0.012368134,
0.016789561,
0.01909582,
0.011801453,
-0.014746875,
0.01573527,
0.007880814,
0.012901868,
0.05672078,
0.022601333,
-0.005841423,
0.012513099,
0.024288194,
-0.013251102,
-0.030811612,
0.00008324151,
0.0045828647,
0.010220019,
0.0316814,
-0.0148127675,
-0.0069912574,
0.025658771,
0.028175887,
0.011630131,
0.014285623,
0.020822218,
0.031365115,
-0.0086056385,
0.029599179,
0.021349363,
0.027147956,
0.034791555,
-0.009304105,
0.017395778,
-0.0063619786,
0.02080904,
-0.012954582,
-0.02290444,
-0.011037094,
0.0074393307,
-0.024762625,
-0.0154585205,
-0.02271994,
-0.01831828,
0.013125905,
-0.0136003345,
0.016460095,
-0.0061313524,
-0.036425702,
0.046441454,
-0.010022339,
-0.03771721,
0.024380445,
0.02510527,
0.003195815,
0.0031760472,
0.0062236027,
-0.0034890394,
0.006259844,
0.01909582,
0.034580696,
-0.018015172,
0.009930089,
0.032682974,
0.010022339,
-0.008473852,
-0.008757193,
0.0036867186,
0.0257642,
0.021586578,
-0.014799589,
0.000052817435,
-0.012341777,
-0.0029816625,
-0.03054804,
0.0156562,
-0.009877375,
-0.015537592,
0.012835975,
0.038586996,
0.019596606,
0.0019487883,
0.0014422351,
0.026739419,
0.021336185,
0.021705186,
0.0020047973,
0.017593456,
-0.019188069,
-0.0062071295,
-0.019609785,
0.008104851,
0.00954791,
-0.0144569455,
0.0002238306,
0.036135774,
-0.008190512,
-0.0059600305,
0.0052747424,
-0.0004859616,
0.002143173,
0.015089519,
0.04016843,
0.0213889,
0.020954004,
0.019636143,
-0.019807465,
0.004724535,
0.0058348337,
0.022601333,
-0.023497477,
0.009633571,
-0.02347112,
0.02146797,
0.031839542,
0.006240076,
-0.013468549,
-0.023787407,
0.0041973903,
0.031997688,
0.0057195206,
0.013560799,
-0.021454792,
0.007452509,
0.037190065,
-0.015379448,
0.004457668,
-0.023128476,
-0.0053109834,
0.022746297,
0.0057491725,
-0.010997558,
-0.63889945,
-0.02585645,
0.029177463,
-0.01317862,
0.012256116,
0.025355663,
0.0037723798,
-0.017962458,
-0.009363409,
0.021046255,
-0.009053712,
0.0047278297,
-0.0032617082,
-0.029230177,
-0.0024479285,
-0.034712482,
-0.01527402,
-0.002022918,
-0.0008129561,
-0.0010295797,
-0.012209991,
-0.01917489,
0.018041529,
0.01574845,
-0.0053373408,
0.003884398,
0.007702903,
-0.010437466,
-0.026278166,
0.030310825,
-0.021533864,
0.021085791,
0.00858587,
-0.011267719,
0.0515284,
0.0067803995,
-0.024868054,
0.016565524,
0.009791714,
0.04934075,
-0.001197607,
0.006737569,
0.005805182,
-0.0077292603,
-0.014074765,
0.024459517,
0.011564238,
0.02547427,
0.008513388,
-0.008526566,
0.0066683814,
0.0051923757,
-0.018595032,
0.0071625793,
0.010009161,
0.0062104245,
0.014839125,
-0.015959308,
0.0040688985,
0.008987818,
0.0033523112,
0.007926939,
-0.00753817,
-0.020690432,
-0.034053553,
0.016565524,
-0.0010402872,
0.009468838,
0.012967762,
0.0010246376,
0.004704767,
0.013376298,
0.004101845,
0.024064159,
0.015471699,
0.037348207,
0.0032781814,
-0.0066848546,
-0.0010023987,
-0.0017725243,
0.008131208,
-0.0063982196,
-0.0028844702,
-0.010470413,
0.012295651,
0.025777379,
0.00004499263,
0.012236347,
-0.009765357,
0.0041479706,
0.019622963,
-0.0005238501,
0.01889814,
-0.03434348,
-0.013007297,
0.016170166,
-0.028386746,
0.011623542,
-0.007992833,
-0.008862621,
-0.011814632,
0.0007499458,
0.0022156553,
0.012348366,
0.03558227,
-0.013251102,
-0.03589856,
0.018660925,
0.035239626,
-0.0139298,
-0.010569252,
0.00120502,
-0.003294655,
-0.01755392,
-0.0030920336,
-0.015010447,
0.03943043,
0.017316705,
0.0007359435,
-0.02843946,
0.0056536277,
-0.017791135,
0.019135354,
0.005897432,
0.016486453,
0.014404231,
0.016960884,
-0.0034659768,
0.010378162,
-0.011096397,
-0.015379448,
-0.012578992,
0.008572692,
-0.011715792,
0.033157405,
0.011142522,
0.013303816,
0.011597184,
-0.012335188,
-0.030996112,
-0.013587156,
-0.01498409,
0.025830094,
-0.023062583,
-0.006566247,
-0.0054262965,
-0.004523561,
-0.0038613353,
0.01345537,
-0.008948282,
0.03866607,
0.007847868,
0.0043851854,
0.0071032755,
0.013560799,
-0.020308252,
-0.03558227,
-0.009178909,
0.002642313,
-0.004513677,
-0.013784835,
0.0025286474,
0.007643599,
-0.009851018,
-0.0033045388,
-0.0022683698,
0.00071370456,
-0.0031809893,
-0.004984813,
-0.032682974,
-0.009897143,
-0.01823921,
-0.027912315,
0.007531581,
-0.00944907,
0.015959308,
-0.00004746362,
-0.018370995,
-0.0013565741,
-0.007017615,
0.010450645,
-0.02807046,
-0.007742439,
0.0000109135435,
0.0351342,
0.010411109,
0.031628687,
0.012967762,
-0.007999422,
0.034686126,
-0.0025484154,
0.00093732926,
-0.025803735,
0.028808462,
-0.005096831,
-0.00639163,
0.0029207114,
0.012434027,
-0.0046882937,
0.027885959,
0.0006873474,
-0.03178683,
0.010799878,
-0.021599757,
0.008190512,
-0.0024363971,
0.0021250523,
-0.025711486,
0.0074129733,
0.0051989653,
0.005755762,
0.009145962,
-0.01784385,
-0.011985954,
-0.00687265,
0.010220019,
-0.0014537664,
-0.017105848,
-0.019477999,
-0.014773232,
0.0010938254,
0.021889687,
0.019148534,
-0.022548618,
-0.007261419,
0.005307689,
0.01507634,
0.017646171,
-0.017132204,
-0.03215583,
-0.0083157085,
-0.012750314,
0.005574556,
0.017329885,
0.015089519,
0.01317862,
0.013000708,
-0.0021563515,
0.043384016,
0.003044261,
-0.004698178,
0.033368263,
-0.000604981,
-0.0046652313,
-0.019767929,
-0.024090515,
0.0037756744,
0.0034626822,
-0.000025662272,
0.010654913,
0.008269584,
0.011597184,
-0.0115312915,
-0.0067738104,
-0.0044444893,
0.004269873,
0.013290637,
0.011584006,
0.029019319,
0.010233197,
0.027253384,
-0.003250177,
0.00021435847,
-0.026475845,
0.0065530683,
-0.004615811,
-0.0041150237,
-0.0110305045,
-0.02625181,
-0.0125987595,
-0.019043105,
0.019227605,
0.028834818,
-0.024380445,
0.009422713,
0.031101542,
0.011656488,
0.0022008293,
0.013547621,
-0.0003634416,
-0.011340202,
-0.040300217,
0.0153135555,
0.03281476,
-0.01383755,
-0.014087943,
-0.0313124,
-0.038033493,
-0.010061876,
-0.003019551,
-0.005307689,
0.006128058,
0.0022420126,
0.007492045,
-0.01794928,
-0.012809617,
0.040405646,
-0.02604095,
0.0073536695,
0.001912547,
0.013046833,
-0.00055185467,
-0.012737135,
-0.016960884,
0.031417828,
0.006506943,
-0.0045367396,
0.0009052064,
-0.025355663,
-0.0009142667,
-0.017514385,
-0.033183765,
-0.009646749,
-0.0280441,
0.012242937,
0.006259844,
0.00030969756,
-0.002681849,
-0.0038876927,
0.010911897,
-0.023892837,
-0.0071889367,
0.018858604,
0.008658352,
0.007590885,
0.020637717,
0.0023112004,
0.015524413,
-0.013204976,
0.0016497984,
-0.01784385,
-0.025816916,
0.013396067,
-0.004981518,
-0.019530714,
-0.0045367396,
-0.0153135555,
-0.013877086,
0.014430588,
0.018726818,
-0.010061876,
-0.005798592,
-0.0019833823,
0.00049378636,
-0.0132445125,
-0.010964612,
0.021243934,
0.015300376,
0.011775096,
-0.015142233,
0.025197519,
0.039852142,
0.0031760472,
-0.027147956,
0.016328309,
-0.0021761195,
0.029810036,
0.0016950999,
-0.0093172835,
-0.039773073,
0.007913761,
0.024064159,
0.0031167434,
-0.0074788663,
0.001270913,
0.024578124,
-0.0035186913,
-0.019240784,
-0.0010155773,
0.0032056991,
0.007992833,
0.029151106,
0.019161712,
-0.010865771,
0.034158982,
-0.007169169,
-0.014536017,
-0.04198708,
-0.025276592,
-0.00036961908,
-0.023339335,
-0.0046520527,
-0.008098261,
-0.0075645274,
0.0076172417,
-0.018278744,
-0.0013335116,
0.0016094389,
-0.0030623816,
-0.012730546,
-0.01507634,
-0.029124748,
-0.026805311,
-0.027016168,
0.023444762,
-0.030337181,
-0.0013549267,
0.007992833,
-0.0042731673,
0.01870046,
0.013389477,
-0.011465399,
0.01402205,
0.030600753,
0.0094622485,
-0.009323873,
0.0025204108,
-0.03310469,
0.011518113,
-0.0066552027,
0.009633571,
-0.01841053,
-0.014905018,
0.015919771,
-0.0022074187,
0.005172608,
0.017435312,
0.0074656876,
-0.02606731,
0.025355663,
0.032498475,
0.016156986,
-0.0019207838,
-0.004714651,
-0.009231622,
-0.031549614,
-0.021823794,
-0.02328662,
0.006543184,
-0.017922921,
0.01173556,
0.02289126,
-0.010714217,
-0.0027049116,
0.013251102,
0.006793578,
-0.0053109834,
0.0034231462,
0.014615089,
0.027806886,
-0.014865482,
0.02585645,
-0.0076765455,
-0.022864904,
-0.036873776,
-0.024209123,
0.011821222,
-0.0055514933,
-0.018871782,
0.018476425,
-0.013231333,
-0.021705186,
-0.0006181596,
0.0036471828,
-0.012578992,
-0.0007384145,
0.01269101,
-0.012928225,
0.00954791,
0.004533445,
0.00037044275,
-0.007650188,
-0.0028449344,
-0.016618239,
0.0033440746,
-0.0041183187,
-0.008388191,
-0.0056338594,
0.004421427,
-0.028123174,
-0.019596606,
0.014549196,
0.016908169,
0.007531581,
0.0006132176,
0.010220019,
-0.031602327,
0.010259555,
-0.015208126,
-0.04609881,
-0.011056862,
-0.0041084345,
0.027411528,
0.02481534,
0.023998266,
0.017870208,
0.025895987,
0.034475267,
0.020822218,
0.011913472,
0.01709267,
0.0034989233,
-0.013053422,
-0.0004192448,
0.00005920083,
-0.030706182,
0.02604095,
0.001099591,
0.009587445,
-0.011999133,
0.0016646243,
-0.01880589,
0.014615089,
-0.031602327,
-0.030917041,
0.0066947383,
-0.010160715,
-0.0118344,
-0.012776671,
0.0038316834,
0.018713638,
0.015023625,
0.019267142,
0.016552346,
0.023787407,
-0.012559224,
0.042487867,
0.010299091,
0.023998266,
-0.021678828,
-0.009356819,
0.0050144647,
-0.014285623,
0.024406802,
-0.0037756744,
0.0010551132,
-0.0075184023,
-0.015300376,
0.009508373,
-0.008322298,
-0.035160556,
-0.019583428,
-0.013732121,
-0.008467263,
-0.021151684,
-0.011867346,
-0.023642443,
-0.030389896,
0.0151685905,
0.017237633,
-0.011307255,
0.0061610043,
0.0058480124,
-0.021942401,
0.026172737,
-0.011465399,
0.020189645,
-0.013969337,
0.031101542,
0.016591882,
0.009633571,
-0.028676676,
-0.0066222562,
-0.008519977,
0.0044708466,
0.022785833,
0.064206235,
-0.030416252,
-0.0065398896,
0.010378162,
0.007169169,
0.0049650446,
-0.015577128,
-0.0019356097,
-0.01957025,
0.003083797,
-0.016525988,
-0.010944843,
-0.02088811,
0.008546335,
0.009738999,
-0.011689435,
-0.00035705822,
-0.01192665,
-0.016631417,
0.013027065,
-0.0016901579,
0.0026999696,
-0.0036438883,
-0.039825786,
-0.004540034,
-0.023906015,
0.002772452,
-0.0084606735,
0.003923934,
-0.0007330607,
0.016156986,
0.018436888,
0.013613514,
-0.0027642155,
0.011017325,
-0.009580856,
-0.0015353091,
0.03539777,
0.0126053495,
0.001099591,
0.010127769,
-0.003923934,
-0.015695736,
-0.022232331,
0.009000997,
-0.017039955,
-0.029599179,
-0.020163286,
0.020400502,
0.0137453,
0.002732916,
0.0154585205,
-0.034369837,
-0.01259217,
-0.01823921,
-0.02978368,
0.008902158,
-0.041565366,
-0.0017840556,
0.016815918,
0.0014018756,
0.023299798,
0.048787247,
0.0026983223,
0.004599338,
0.03139147,
-0.013066601,
0.009587445,
-0.00906689,
0.0040425416,
-0.008678121,
0.009712642,
-0.0109580215,
-0.031549614,
0.016143808,
-0.021454792,
-0.034027193,
0.0070769186,
-0.0050342325,
0.017685708,
0.011781685,
-0.01909582,
0.019991966,
0.009099836,
0.021942401,
0.010180484,
0.00063422107,
0.020453217,
-0.043199513,
-0.011788275,
-0.0017115731,
-0.0018993685,
-0.013653049,
0.0006593428,
-0.010378162,
0.0044906144,
-0.020782683,
-0.033552766,
-0.021309827,
-0.0029898991,
-0.011201826,
0.004523561,
-0.016644595,
0.0076765455,
-0.015774807,
0.011557649,
0.0016810976,
-0.0042731673,
-0.029599179,
0.0067803995,
-0.008941693,
-0.007847868,
0.00042212763,
-0.002928948,
0.0005007875,
-0.019267142,
-0.01688181,
0.0077622067,
-0.037269134,
0.03073254,
-0.0024611072,
-0.008328888,
-0.018094243,
0.009844429,
-0.058723927,
-0.021520685,
-0.012526277,
0.0051594293,
-0.017857028,
0.011478577,
-0.008856032,
0.0027395054,
0.0016044969,
0.015959308,
-0.021494327,
-0.026489025,
0.008572692,
-0.011340202,
0.021639293,
0.011333613,
-0.00820369,
-0.022917619,
0.036109418,
0.0008541393,
-0.010009161,
0.04227701,
-0.019359391,
0.001947141,
-0.022192795,
0.00012982999,
-0.0070835077,
0.0048167855,
0.01613063,
-0.008124619,
-0.00983125,
0.0029009436,
-0.014496481,
-0.006002861,
0.004467552,
0.003335838,
0.0009274453,
-0.00673098,
-0.013303816,
-0.02071679,
0.008025779,
-0.026278166,
0.011399506,
0.015142233,
-0.0066749705,
0.00050737686,
0.025237055,
-0.0047772494,
-0.027912315,
0.005376877,
-0.03331555,
-0.023299798,
-0.005465832,
0.0035384593,
-0.017158562,
-0.0045565073,
0.002184356,
-0.03284112,
-0.0021266995,
-0.018001994,
0.00042048033,
-0.023497477,
0.0024627545,
0.025737843,
-0.019807465,
-0.0019174891,
-0.008902158,
-0.015972486,
-0.020874932,
0.0014274091,
-0.009567677,
0.0005893314,
-0.006572836,
-0.0029207114,
-0.0024924064,
-0.0037657905,
-0.033262834,
-0.010826236,
-0.012130919,
0.007116454,
0.19799557,
-0.016591882,
0.010608789,
-0.0036669509,
-0.0041446756,
0.012203401,
0.0040063,
-0.012552635,
-0.0032485295,
0.0059765037,
0.02825496,
0.011847579,
-0.006193951,
0.007893993,
0.0078017423,
-0.023405228,
-0.015998844,
-0.006421282,
-0.016446916,
-0.021968758,
0.002270017,
-0.010753754,
0.012644885,
0.025698308,
0.03263026,
-0.011676257,
-0.012776671,
0.0047706603,
0.013284048,
0.0045169718,
-0.02376105,
0.014667803,
0.0072680083,
-0.008368423,
0.009989393,
0.016183345,
-0.02024236,
-0.000006283653,
0.00353187,
0.0020657484,
-0.024802161,
0.005231912,
-0.011748739,
-0.012302241,
0.017026776,
0.004945277,
-0.006378452,
-0.022917619,
-0.0024940537,
0.008500209,
-0.03750635,
0.006526711,
-0.0006235134,
0.0061017005,
-0.007841279,
0.0015254251,
-0.008019189,
0.005353814,
-0.0101014115,
0.0278596,
-0.015853878,
0.0019932662,
-0.013639871,
0.040695574,
-0.017817494,
0.03044261,
-0.005469127,
0.0022650752,
0.013211566,
-0.03257755,
0.0142460875,
0.0054625375,
-0.008987818,
-0.01860821,
0.009007586,
-0.0011687787,
0.021336185,
-0.00091261935,
0.026963454,
0.027806886,
0.006315853,
-0.0072284727,
-0.035924915,
0.022113724,
0.0094622485,
-0.019412106,
0.026264988,
-0.005933673,
-0.014008872,
-0.010338627,
-0.0025895988,
-0.024828518,
0.0060819327,
0.0071428115,
0.017474849,
-0.008651763,
-0.0011630132,
0.008987818,
0.014707339,
-0.034027193,
-0.023220727,
0.09035261,
0.0026489024,
0.010668092,
-0.0045762756,
-0.0038481567,
-0.0030211983,
0.0010147537,
0.008829675,
-0.02022918,
0.011913472,
-0.040089358,
0.0015361328,
-0.0032518243,
-0.0060951114,
0.029599179,
-0.0016522694,
-0.00018264742,
0.023840122,
0.002485817,
-0.007663367,
-0.023088941,
0.001577316,
0.026976634,
-0.0077358494,
0.0016514458,
-0.031180613,
0.0099235,
-0.002233776,
-0.03054804,
0.017026776,
0.011610364,
0.017804315,
0.020334609,
-0.0020064448,
-0.018384174,
0.020387324,
-0.020664075,
-0.023537014,
0.021454792,
-0.013310405,
-0.00954791,
-0.009758768,
-0.0067606317,
0.0038514514,
-0.0052352063,
0.022693582,
0.012038669,
-0.012427438,
-0.021257112,
-0.007861046,
-0.019939251,
0.0043489444,
-0.00039762366,
0.041855294,
-0.030996112,
-0.013771657,
-0.014140658,
-0.016012022,
-0.0046882937,
-0.01794928,
-0.0048991516,
0.006197246,
-0.0005156135,
-0.012756904,
0.01823921,
-0.16573432,
0.012012311,
0.021797435,
-0.01421973,
0.042066153,
-0.01173556,
-0.0067606317,
-0.008638585,
-0.0002691321,
0.026185917,
0.04312044,
-0.008131208,
-0.028703032,
-0.027253384,
-0.011702614,
0.0014941259,
-0.00543618,
0.029520107,
0.011860757,
0.012196812,
0.018937675,
-0.0153135555,
0.02567195,
-0.0061478256,
0.00014898017,
0.0127437245,
-0.0011127697,
0.002787278,
0.0072877766,
-0.011215005,
-0.004675115,
-0.0028251666,
0.04343673,
0.020202823,
0.009093247,
0.00047484212,
-0.004760776,
-0.023233905,
0.018476425,
0.015708914,
0.027121598,
0.0022354233,
-0.005212144,
-0.0073734373,
-0.015998844,
0.009752179,
-0.006338916,
-0.023312977,
0.027464243,
-0.02395873,
0.029520107,
-0.031602327,
0.009093247,
0.02938832,
0.017830672,
0.0033226593,
0.003742728,
0.001912547,
0.0068924176,
0.002802104,
0.002319437,
-0.022654045,
0.008625406,
0.0016300305,
0.015247663,
-0.033078335,
-0.008309119,
0.022219151,
-0.027596029,
0.004941982,
-0.025895987,
-0.0075645274,
0.027437884,
-0.030310825,
0.009765357,
0.039245926,
0.0032172303,
0.004553213,
0.006661792,
0.014259266,
-0.007011025,
-0.0025072324,
-0.034317125,
-0.008513388,
-0.021204399,
0.0024133346,
0.0034593875,
0.014232908,
0.008197101,
-0.021876508,
0.004045836,
-0.03244576,
0.013666228,
-0.012684421,
0.02232458,
0.034896985,
-0.024195945,
-0.007426152,
-0.022785833,
-0.0054164124,
0.012183634,
-0.0068001673,
-0.013033655,
0.0111029865,
0.00094968424,
0.010826236,
-0.025685128,
-0.004915625,
0.039694,
-0.0072284727,
-0.012565813,
-0.016104272,
0.00049749285,
0.028940247,
-0.009053712,
0.004171033,
0.023906015,
-0.0020064448,
0.0015270725,
-0.025052555,
0.07764842,
-0.016460095,
-0.008421138,
0.018911319,
-0.01640738,
-0.031101542,
-0.12662017,
-0.0137453,
0.032788403,
0.020940825,
-0.014325159,
-0.000027155162,
-0.0035516378,
0.003265003,
-0.00043654177,
0.0136003345,
-0.0151685905,
-0.011228183,
-0.016104272,
-0.018581852,
0.011794864,
0.0052220277,
0.0050737686,
-0.020400502,
-0.037479993,
0.016842276,
0.012150687,
-0.014206551,
0.01594613,
-0.0047673653,
0.009969626,
-0.024973484,
-0.018107424,
0.031655043,
0.006325737,
0.040247504,
-0.0064871754,
-0.0049979915,
0.027174313,
0.0028301084,
-0.023260262,
0.021718364,
0.0045762756,
-0.025975058,
0.02986275,
-0.00013816959,
-0.0026999696,
0.009686285,
-0.0039865323,
-0.00367354,
0.0029668366,
-0.014259266,
-0.0058546015,
-0.0048826784,
0.031365115,
-0.009310694,
-0.014562374,
-0.0067803995,
-0.053979624,
-0.026778953,
0.017883386,
0.012875511,
0.016446916,
0.03465977,
0.0048299637,
0.0021118738,
0.009152551,
-0.0133169945,
0.0005201436,
0.013488317,
0.04952525,
-0.01107004,
0.011728971,
-0.018252388,
0.019504357,
-0.022087365,
-0.004256694,
-0.013231333,
-0.0040919613,
-0.010226608,
-0.01230883,
0.005314278,
0.0001770877,
-0.023326157,
-0.0039272285,
-0.007531581,
-0.033895407,
-0.013409245,
0.014786411,
-0.009099836,
0.030917041,
0.0011234772,
0.020967184,
-0.007300955,
0.015432163,
-0.0280441,
-0.0031216855,
0.04572981,
0.013310405,
-0.0049584555,
-0.006477291,
0.0059600305,
0.0028152824,
-0.015089519,
0.017725242,
0.020347787,
-0.032129474,
-0.0021299943,
-0.055666488,
0.021230755,
-0.021639293,
0.023036227,
0.014641446,
-0.018964034,
-0.0019537304,
-0.023774229,
0.03036354,
0.027912315,
-0.010766932,
0.009271159,
-0.01613063,
0.023971908,
-0.026765775,
-0.015260841,
0.03595127,
-0.0037954424,
0.013521263,
0.0320504,
-0.018858604,
-0.014905018,
-0.021336185,
0.008968051,
0.011992543,
-0.004849732,
-0.035872202,
0.023299798,
-0.012084793,
0.026317703,
0.018001994,
-0.022667225,
-0.018871782,
0.014206551,
-0.04085372,
-0.02088811,
-0.008809906,
0.029282892,
0.023326157,
0.020914469,
-0.0049090357,
-0.027147956,
0.014760054,
-0.021481149,
0.0102463765,
-0.010503359,
-0.02738517,
0.0087440135,
0.008546335,
-0.047311243,
0.035924915,
0.022469545,
0.012849154,
-0.023932373,
0.0158407,
0.012493331,
0.007531581,
-0.008552924,
-0.010081643,
-0.023405228,
-0.00007433565,
0.021889687,
0.00015176003,
0.0044411947,
0.030389896,
-0.018041529,
-0.032182187,
0.0000021621172,
0.0023309682,
-0.012328598,
-0.007709492,
-0.011689435,
-0.010233197,
-0.0034593875,
0.019609785,
-0.009435891,
-0.0037097812,
-0.0009002644,
-0.027437884,
0.027147956,
0.005363698,
0.0033901997,
-0.025276592,
0.020954004,
0.02654174,
-0.009758768,
-0.004164444,
0.034686126,
-0.009752179,
-0.00811803,
-0.00086567056,
0.010813057,
-0.0002740741,
-0.01278985,
0.0015814343,
-0.0049979915,
-0.0054790108,
0.017263992,
0.013547621,
0.0278596,
0.0047574816,
-0.0005184963,
-0.0017593456,
-0.0027279742,
-0.015524413,
0.027912315,
-0.036083058,
-0.050974898,
-0.019016746,
-0.0040524253,
0.015089519,
0.015089519,
0.016947703,
-0.00013158028,
-0.0137453,
0.033131048,
0.0045861593,
0.021494327,
-0.017922921,
0.026778953,
0.0059139053,
-0.00006697416,
0.008355244,
-0.020110574,
0.017250812,
0.004263283,
0.017817494,
-0.018568674,
0.034686126,
-0.007808332,
0.028017744,
-0.007327312,
-0.02967825,
-0.016433738,
-0.0074656876,
-0.010160715,
0.023049405,
0.028281316,
-0.010318859,
0.081812866,
-0.0064179874,
-0.030574396,
-0.011696025,
-0.025144806,
0.021046255,
-0.010022339,
0.018792711,
-0.03120697,
-0.010371573,
0.012842564,
-0.009211855,
0.03376362,
-0.038718782,
-0.034317125,
0.017105848,
-0.018871782,
0.00886921,
0.0008599049,
-0.015194948,
0.01642056,
-0.01623606,
-0.009488606,
0.02042686,
-0.023128476,
-0.008091672,
0.02290444,
0.005189081,
-0.0012206696,
-0.035081483,
0.024920769,
-0.0079598855,
-0.028096816,
-0.0132445125,
0.012262705,
-0.0069714896,
-0.020769503,
-0.02481534,
0.00048019594,
0.030126324,
-0.014232908,
0.019912893,
-0.02843946,
-0.015353091,
0.00663214,
-0.010859182,
-0.021507507,
-0.0118344,
-0.0035384593
] |
We have investigated HO endonuclease-induced double-strand break (DSB) recombination and repair in a LACZ duplication plasmid in yeast. A 117-bp MATa fragment, embedded in one copy of LACZ, served as a site for initiation of a DSB when HO endonuclease was expressed. The DSB could be repaired using wild-type sequences located on a second, promoterless, copy of LACZ on the same plasmid. In contrast to normal mating-type switching, crossing-over associated with gene conversion occurred at least 50% of the time. The proportion of conversion | [
-0.019760454,
0.0012197392,
-0.004749848,
-0.028023422,
-0.05615557,
0.02459864,
0.0031784568,
0.013271034,
-0.014378652,
0.00004454044,
0.0004850077,
0.02364731,
0.0011331004,
0.011551848,
-0.0063501187,
0.029056294,
0.01931197,
-0.015887188,
-0.0034179878,
0.008378487,
-0.03095895,
-0.023389094,
-0.004946909,
-0.008405668,
0.020847687,
0.0064554443,
0.016376443,
-0.0102199875,
-0.02527816,
0.012842936,
0.002699395,
0.014568918,
-0.030877408,
0.0032447102,
-0.008806584,
-0.016091043,
0.027506987,
0.0052934643,
0.019108115,
-0.022831887,
0.0075426768,
0.023334732,
-0.009554057,
0.017477265,
0.01497663,
0.009757914,
-0.0028420943,
-0.01327783,
-0.0023698276,
0.015574608,
0.0162949,
0.018048063,
-0.006360311,
0.014134025,
-0.020385614,
-0.0036252416,
0.030496877,
0.015411523,
0.009988951,
-0.027099274,
-0.008480415,
0.0077669187,
-0.032019004,
0.02760212,
-0.028838847,
-0.0021557785,
0.025726644,
-0.0031105047,
0.006608336,
-0.0097715035,
0.04560941,
-0.0028845642,
0.0076174242,
-0.0053818016,
0.018088834,
-0.023470636,
-0.018347051,
-0.008650295,
0.009289044,
0.017925749,
0.01764035,
-0.0042639906,
-0.020059444,
0.016702613,
0.010165625,
-0.00061369187,
0.0001592626,
0.01330501,
-0.007576653,
0.006030744,
0.023497816,
0.029980442,
0.017463675,
0.015479475,
-0.01993713,
0.011551848,
0.0034213853,
0.014147615,
-0.002964408,
-0.022804705,
-0.016457984,
-0.013175901,
-0.008378487,
-0.017735483,
-0.008922103,
-0.00474645,
0.022437764,
-0.013678746,
-0.0016215056,
0.0068121925,
-0.015017401,
0.034193467,
-0.010464614,
-0.016172586,
0.025808185,
-0.034111924,
-0.0018856692,
-0.007046627,
-0.011905198,
-0.00257878,
0.027996242,
0.037645433,
0.011049002,
-0.036395114,
0.023484226,
0.012829346,
-0.023035742,
0.017708303,
0.00050326984,
0.005935611,
0.02859422,
0.019665321,
0.020684602,
0.017681122,
-0.024313241,
0.019556599,
-0.019896358,
-0.0279147,
-0.027085684,
-0.044141646,
0.019556599,
0.019746864,
-0.0075290864,
-0.014500966,
0.009832661,
0.008290149,
0.028730124,
0.008466825,
0.013930169,
0.0054803323,
0.014528147,
-0.0039106403,
0.010240373,
-0.011932379,
0.0038732665,
0.031720012,
0.002716383,
0.021554388,
-0.031720012,
-0.015561018,
0.0066457097,
0.0014762582,
0.0014329387,
0.007148555,
0.014759184,
0.035606872,
0.0011764198,
0.0015153305,
0.00490274,
-0.016865697,
-0.011225677,
0.01793934,
-0.022886248,
0.017694712,
0.002758853,
0.010682061,
0.0023358515,
-0.00039199836,
-0.020929229,
-0.014840726,
-0.010906303,
-0.00080693053,
0.021105904,
0.011551848,
-0.023035742,
0.0052730786,
-0.0039072423,
-0.016756974,
-0.014201977,
-0.0025974668,
-0.017123915,
0.025821777,
0.00019525595,
0.012632285,
-0.64277196,
-0.009289044,
-0.00059075805,
-0.017721893,
0.007957185,
0.015642561,
0.005266283,
0.007902822,
-0.007345616,
0.022464946,
-0.02924656,
0.0029304319,
0.030116346,
-0.004440666,
-0.019094525,
-0.017912159,
0.027357493,
0.00013441764,
0.030306611,
0.012007126,
-0.021241808,
-0.0033857105,
-0.029871719,
0.0073999777,
0.021731064,
-0.0018245124,
0.02330755,
0.005796309,
0.00081542454,
-0.004005773,
-0.011776089,
0.010084083,
-0.024041433,
-0.007787304,
0.04650638,
0.011212087,
0.010525771,
0.021500027,
0.012190596,
0.037074637,
-0.008901718,
-0.0075698574,
0.03199182,
0.0063840942,
-0.030170707,
0.011314015,
0.0059322133,
0.01598232,
-0.019665321,
-0.01727341,
0.001200203,
0.00034337016,
0.0004684444,
-0.0047702333,
0.008677476,
0.024109384,
0.018523727,
-0.025767414,
0.035851497,
0.0059933704,
-0.0061598527,
0.022165956,
-0.013733108,
-0.024177337,
-0.0017463675,
-0.03237235,
-0.0054939226,
0.009859841,
0.00091735256,
0.008228992,
0.010240373,
0.006336528,
0.0070534223,
0.022818295,
-0.0042843763,
0.022464946,
0.0016274514,
0.022981381,
-0.011314015,
0.023538588,
0.005065825,
-0.020548698,
-0.03960245,
-0.0019315368,
0.050637864,
-0.011443124,
-0.011538257,
0.02362013,
-0.01630849,
-0.022777526,
0.017422903,
0.02325319,
-0.01327783,
-0.0111917015,
-0.023688082,
0.020385614,
-0.0009853046,
-0.0039548087,
0.0038834594,
-0.025047123,
-0.020168167,
-0.01113734,
-0.008065907,
-0.009554057,
0.015030992,
0.014419423,
-0.019203248,
0.0033942047,
0.033187777,
-0.03264416,
-0.018537318,
-0.0018822716,
-0.012883707,
0.004692089,
-0.0044372682,
-0.03027943,
0.022437764,
0.006030744,
-0.010451024,
-0.030659962,
0.008385282,
-0.011388763,
-0.0050522345,
-0.02031766,
-0.0032498066,
0.017069554,
0.0041960385,
-0.02826805,
0.015044582,
-0.00014556602,
0.0012044499,
-0.008188222,
0.009119164,
-0.03424783,
-0.014093254,
-0.0102947345,
-0.009221092,
0.0008816778,
0.013264239,
-0.023891939,
-0.041314844,
0.017613169,
0.008337716,
0.0050182585,
-0.0074407486,
-0.017762665,
-0.023090104,
-0.0053478256,
0.014881497,
0.009248273,
0.028376773,
-0.0053851996,
-0.024381192,
-0.0025923704,
-0.01594155,
-0.007685376,
-0.020915639,
-0.032019004,
-0.0020300674,
-0.01701519,
0.0016537829,
0.012258548,
0.0064180703,
-0.013019611,
0.0065233964,
-0.013651566,
0.027561348,
-0.0012791972,
-0.011089774,
-0.011402353,
0.0111917015,
-0.022342632,
-0.026487706,
0.003346638,
0.0070670126,
0.025577148,
0.0046411245,
-0.0038800617,
0.011579028,
0.008330921,
-0.00019440654,
-0.01031512,
-0.014949449,
-0.015003812,
0.011504281,
0.004423678,
0.028730124,
-0.012931274,
0.008412463,
0.018428594,
-0.00847362,
0.0032379148,
0.017667532,
0.01398453,
0.009764709,
0.0062787686,
0.0013862217,
0.015493066,
0.009526877,
0.020385614,
0.03392166,
-0.0038800617,
0.02655566,
-0.027289541,
0.022723163,
-0.034574,
0.0071757357,
0.0044372682,
0.020032262,
0.0016920059,
-0.0020827302,
-0.015737694,
-0.020725373,
-0.016430805,
0.0135156615,
-0.00067782163,
-0.0033500358,
0.011565438,
0.010858737,
0.016756974,
-0.015438704,
-0.00731164,
0.022070823,
0.0029932875,
-0.002587274,
0.0015323185,
0.000110315894,
0.0074611343,
-0.0073863873,
0.0049163303,
0.019080933,
0.0143378815,
-0.01462328,
0.009261863,
0.02628385,
0.012475995,
0.013719518,
0.00913955,
0.04226617,
0.010247168,
-0.006173443,
0.017409313,
0.008847356,
-0.009390973,
0.015126125,
0.010138445,
0.014283519,
0.02164952,
-0.011565438,
0.017382132,
-0.009825866,
0.005300259,
-0.027072094,
0.008262969,
0.020018673,
-0.0036999888,
-0.0059831776,
0.030442515,
0.036884367,
0.009037621,
-0.017191866,
0.0050284513,
0.003424783,
-0.015696922,
-0.0018024279,
0.0000817548,
0.007236893,
-0.0016894577,
-0.012605104,
-0.005877852,
-0.0057147667,
0.00076318637,
-0.007026241,
-0.0286214,
0.0129924305,
0.00498768,
-0.00043829068,
0.030823046,
0.015044582,
-0.014066073,
-0.013610794,
-0.03430219,
0.02859422,
0.023171647,
0.0041722553,
-0.0063059498,
-0.021826196,
0.0074067726,
-0.011884812,
0.020086624,
0.008609524,
0.008759018,
0.042782605,
0.0059559965,
-0.020806916,
-0.013712722,
0.006937904,
-0.038324952,
0.031149216,
-0.0004650468,
0.009887022,
0.0081202695,
-0.022111595,
-0.017803436,
0.060939394,
0.0010039915,
0.0026756118,
-0.014949449,
-0.0027078888,
-0.035389423,
0.00997536,
-0.006713662,
-0.01229932,
-0.006791807,
-0.011001436,
-0.0019111512,
-0.02159516,
-0.0017353253,
0.015017401,
0.0024122975,
-0.032317992,
-0.023361912,
-0.0022984778,
0.016675431,
0.02622949,
0.029464006,
-0.022206727,
0.009676371,
0.012720622,
0.013400143,
0.0062447926,
-0.04291851,
0.014025302,
-0.0009292442,
-0.008031932,
-0.011918789,
0.013597203,
-0.008242583,
0.006937904,
0.02292702,
0.012870117,
-0.0459084,
0.0020997182,
-0.01014524,
-0.020113805,
0.0041722553,
0.002639937,
0.041804098,
0.021554388,
-0.004260593,
0.018224739,
0.019678911,
0.017884977,
-0.009662781,
-0.0114159435,
0.02954555,
0.01180327,
0.028893208,
0.012829346,
-0.022016462,
0.015370752,
-0.016729793,
-0.0026161536,
0.0029796972,
0.020140985,
0.029001933,
0.004338738,
0.024625821,
0.012951659,
-0.008677476,
-0.0046649077,
0.016457984,
-0.032426715,
-0.01993713,
0.029083474,
-0.03063278,
-0.02696337,
-0.020100214,
0.0023035742,
-0.024027843,
-0.008086293,
-0.021391302,
-0.019216837,
-0.01380106,
-0.016145406,
-0.018632451,
0.026759515,
0.0027095878,
-0.00616325,
-0.023049332,
-0.012720622,
-0.029518368,
-0.016811335,
-0.02160875,
-0.016743384,
-0.021635931,
-0.040798407,
-0.00573855,
0.024449145,
0.0019349344,
0.016566709,
-0.009125959,
-0.01830628,
0.002870974,
-0.027751615,
-0.0027265758,
-0.0025125267,
-0.040064525,
-0.0061768405,
-0.005123584,
-0.0001281533,
-0.0046988837,
-0.0076514003,
0.01163339,
0.008426053,
-0.005840478,
-0.0021455858,
-0.003424783,
0.0077397376,
0.018904258,
0.011028617,
0.018836306,
-0.0020657422,
0.00043107077,
0.002852287,
-0.03927628,
-0.030415334,
-0.030496877,
-0.012231368,
-0.015017401,
-0.013671951,
0.00042024092,
0.0021659713,
4.6451592e-7,
0.002869275,
-0.017409313,
-0.0008510993,
0.03731926,
0.058928013,
0.0175724,
-0.000120084,
0.003312662,
-0.008330921,
0.013712722,
0.01015883,
-0.027316721,
0.018836306,
-0.0063840942,
-0.024394784,
0.034084745,
0.014664051,
-0.036041763,
-0.0004053764,
-0.0005780171,
-0.0020521516,
0.03960245,
0.003363626,
-0.0064452514,
-0.009941384,
-0.019814815,
-0.0087862,
0.0032311196,
0.0048279925,
-0.010084083,
-0.013576819,
-0.0070670126,
-0.00051601086,
-0.013406938,
-0.013101154,
-0.026338212,
-0.01630849,
0.016145406,
-0.0076514003,
-0.014351471,
-0.0033534335,
0.005782719,
-0.026093585,
-0.019515827,
-0.021567978,
-0.021785425,
0.0055041155,
-0.0073999777,
0.037047453,
0.039656814,
0.043027233,
-0.022641622,
0.0076989667,
0.02796906,
0.0015994213,
-0.0054361634,
-0.0073863873,
0.011171316,
-0.021336941,
-0.011171316,
0.020983592,
-0.0020623445,
0.023470636,
0.0072708684,
0.022342632,
0.027629301,
-0.0062651783,
-0.0043863044,
0.021866968,
-0.036775645,
-0.012503176,
-0.0043523284,
-0.0026280454,
0.0037543504,
-0.040744044,
0.008093088,
0.03555251,
0.0066151316,
0.0054531517,
0.01380106,
0.03593304,
-0.012537152,
0.022247499,
0.005928816,
0.017912159,
-0.0010447627,
-0.006771421,
-0.004858571,
0.0071621453,
0.023049332,
0.008222197,
0.007080603,
-0.005490525,
-0.015370752,
-0.003168264,
0.0042979666,
-0.030360973,
-0.0074679297,
-0.022437764,
-0.029029112,
-0.008242583,
-0.032671344,
-0.008514391,
-0.03990144,
-0.00590843,
-0.0037339649,
-0.008595933,
0.013420529,
0.0123265,
-0.0023001768,
0.029762994,
0.010648085,
0.029681452,
-0.01265267,
0.015452295,
0.014256339,
0.0013462999,
-0.035226338,
0.0057487427,
0.00084727706,
-0.000257156,
0.022451354,
0.033350863,
-0.011606209,
0.00057631824,
-0.0030595406,
-0.0023766228,
-0.013692337,
-0.017246228,
0.008704657,
-0.009003646,
-0.0003104559,
-0.0029185403,
0.016077453,
0.0049842824,
0.021010771,
-0.01895862,
0.037264902,
-0.0049401135,
-0.0067510353,
-0.020793324,
0.010362687,
0.01465046,
0.0072300974,
-0.018333461,
0.0063059498,
-0.008133859,
-0.012408043,
-0.006173443,
0.0052730786,
-0.013651566,
0.03237235,
-0.025577148,
0.012278934,
-0.0023273574,
0.016852107,
-0.03125794,
-0.035063256,
0.013338986,
0.02859422,
-0.024190927,
0.006071515,
0.006649107,
0.024870448,
-0.009146345,
0.018849896,
-0.016580299,
-0.005232307,
-0.019053753,
-0.0008438794,
0.026990552,
0.009384178,
0.012645875,
-0.014229158,
-0.014038892,
0.0007568159,
-0.012122644,
-0.026827468,
0.01363118,
-0.04487553,
0.0026161536,
-0.0045663775,
0.024707362,
0.022220317,
0.0056570075,
-0.0006417221,
-0.004678498,
0.027996242,
-0.016118225,
0.003047649,
0.007454339,
-0.003005179,
-0.0229542,
0.025074303,
0.008527981,
-0.003210734,
0.011273244,
-0.009669576,
-0.006217612,
-0.0068291803,
-0.010654881,
-0.009757914,
0.01462328,
-0.017110325,
0.014528147,
-0.021146676,
0.021432074,
0.010872327,
-0.00799116,
0.016430805,
-0.017898569,
0.016729793,
-0.0024564664,
-0.0058710566,
-0.032154907,
-0.009356996,
-0.02924656,
-0.006173443,
-0.028567038,
0.0024224904,
0.01047141,
-0.008745428,
0.005565272,
-0.004780426,
-0.019678911,
-0.01363118,
-0.025101485,
0.019026572,
0.0019825008,
-0.00232396,
0.014908678,
0.0009946481,
0.0018822716,
0.026664382,
-0.024707362,
0.0056807906,
0.005775924,
-0.01594155,
-0.023348322,
-0.022057233,
-0.016009502,
0.02631103,
0.012115849,
-0.011280039,
-0.00068164396,
-0.025767414,
-0.05161637,
-0.012931274,
0.006893735,
-0.0014626677,
0.0110422075,
0.027221588,
-0.008249378,
-0.00449163,
0.012000331,
0.021092314,
-0.0048211976,
-0.009785094,
0.009893818,
0.011252859,
0.032345172,
0.0219621,
-0.032943152,
-0.002067441,
0.00690053,
0.018564498,
-0.010777194,
0.008079498,
-0.0017030481,
-0.00028200098,
-0.00026565001,
-0.00457657,
0.029192198,
0.016349262,
0.010532566,
-0.029273741,
-0.013719518,
0.014066073,
-0.0015747886,
-0.016077453,
-0.013855422,
-0.014568918,
-0.0005329988,
0.011266449,
-0.009289044,
-0.019108115,
-0.0010710941,
-0.029572729,
0.0068189874,
0.024163747,
-0.00947931,
0.020698192,
0.006139467,
0.0030340587,
0.0010702447,
-0.012183801,
-0.018183967,
-0.0075426768,
0.010906303,
-0.013114745,
-0.008439643,
-0.008201811,
0.011918789,
-0.006601541,
0.013773879,
0.009384178,
-0.0081950165,
-0.026691563,
0.033432405,
0.00029707784,
-0.026677972,
-0.020018673,
0.010036517,
-0.0144873755,
-0.005755538,
0.013746698,
0.010063698,
-0.0087997895,
0.015098944,
0.005177946,
-0.030170707,
0.00038605253,
-0.006635517,
-0.011422738,
-0.004005773,
-0.0015263727,
0.20059443,
0.0039683995,
-0.0024955387,
0.008262969,
0.005687586,
-0.0019230428,
0.009458925,
0.0052934643,
-0.017803436,
0.011599414,
0.009125959,
-0.001353095,
-0.009384178,
-0.008351306,
0.023103695,
-0.0026450332,
-0.02158157,
-0.009486105,
-0.028567038,
0.004270786,
0.009941384,
-0.021160265,
0.007909617,
-0.008127064,
0.007970775,
-0.01727341,
-0.027479807,
-0.022111595,
-0.009683167,
0.034465276,
-0.03093177,
0.00045145638,
0.014419423,
0.01664825,
0.006737445,
0.00515756,
-0.00025524487,
-0.020929229,
0.011871222,
-0.010464614,
-0.0075970385,
-0.00018941631,
0.01166057,
0.0035742775,
-0.019271199,
-0.007685376,
0.003492735,
-0.013998121,
-0.0016333972,
0.003628639,
-0.03364985,
0.019026572,
-0.00056612544,
0.030986132,
0.007862051,
-0.026378984,
0.036857188,
-0.01931197,
-0.0027622506,
0.022763934,
-0.014242749,
0.019746864,
-0.024231698,
-0.0038460856,
-0.002826805,
0.006428263,
0.0021659713,
0.026392573,
0.01398453,
-0.017477265,
0.015357162,
-0.01496304,
-0.014446604,
-0.011511076,
-0.016852107,
-0.010885918,
0.030795867,
0.010124855,
0.021024363,
0.012591514,
0.0021438869,
-0.022043644,
0.00086256623,
-0.006329733,
-0.004382907,
-0.019665321,
0.013692337,
0.0018720787,
-0.017409313,
0.00067782163,
0.027099274,
-0.020372022,
-0.017219048,
0.003859676,
-0.002313767,
-0.010940279,
-0.0074611343,
0.014161206,
-0.0067850114,
0.0054633445,
-0.04229335,
0.050991215,
-0.0043659187,
-0.011015026,
-0.0054871277,
0.011565438,
0.012475995,
0.0036999888,
0.0070058554,
0.0031648665,
0.024394784,
-0.027058505,
-0.0025838765,
-0.013345782,
0.002288285,
0.02356577,
0.024884038,
-0.025821777,
0.037699793,
-0.008881332,
-0.010206397,
-0.033350863,
-0.0053478256,
0.031774376,
-0.023022152,
-0.0032599992,
-0.02299497,
-0.0032447102,
-0.033051874,
-0.03264416,
0.0020776337,
0.0016554816,
0.014854317,
0.0086435,
0.008711452,
-0.008616319,
0.0111917015,
0.003594663,
-0.026650792,
0.0017718496,
0.0060171536,
-0.009812275,
0.011123749,
0.003842688,
-0.0074747247,
-0.02527816,
0.02095641,
0.011782885,
-0.01993713,
-0.008351306,
-0.0135904085,
0.0058710566,
-0.007114579,
-0.0014252941,
-0.0075698574,
-0.019352742,
-0.024476325,
-0.050284512,
-0.0068801446,
0.025128666,
-0.037292082,
0.0075970385,
0.017708303,
-0.0018839705,
0.0070534223,
0.00021426128,
-0.17352234,
0.010349096,
0.007868847,
-0.023511408,
0.033731394,
0.025522787,
0.034818627,
0.004800812,
0.001819416,
0.018863488,
0.022777526,
0.031230759,
-0.060395777,
-0.026120765,
-0.023973482,
0.012673056,
-0.0027554554,
0.012659466,
0.0123944525,
0.00025949188,
0.009907408,
-0.02495199,
0.018061653,
-0.0065098056,
-0.006890337,
0.009988951,
-0.009221092,
0.0062583834,
0.009227888,
-0.021173857,
-0.011028617,
0.0162949,
0.013039997,
-0.024122976,
-0.0017353253,
-0.0041009057,
0.007345616,
0.027167227,
0.0070738075,
0.008392077,
0.02292702,
0.0014915473,
-0.010607314,
-0.017246228,
-0.010532566,
0.026596429,
0.007957185,
-0.016050272,
0.0018907656,
0.016240539,
0.012020716,
-0.013705927,
0.04128766,
0.025414065,
0.015860006,
-0.0010770399,
0.0025074305,
0.022492126,
-0.016485166,
-0.011755704,
0.0058914423,
-0.024150155,
0.044141646,
-0.00507262,
-0.01000254,
-0.037128996,
-0.010566543,
-0.005167753,
-0.024761725,
0.015900778,
-0.006992265,
0.009146345,
0.012707032,
0.0034825422,
0.007984365,
0.0135904085,
0.007250483,
0.01015883,
0.0016673732,
-0.032290813,
-0.024041433,
0.026365392,
-0.032046184,
-0.009812275,
-0.0012902394,
-0.0010744917,
0.005004668,
0.0010192806,
-0.0055924533,
0.005011463,
0.011443124,
-0.022587258,
0.012618694,
-0.022030052,
-0.00024271621,
0.0085755475,
-0.0031037095,
0.00500127,
-0.011089774,
0.020766145,
0.0011934078,
-0.01860527,
-0.013685541,
0.027425444,
0.028757304,
-0.008412463,
-0.024680182,
0.006825783,
0.054388814,
-0.014718412,
-0.0052594882,
-0.008548367,
0.01929838,
0.034410916,
0.0045969556,
0.04492989,
-0.027085684,
-0.0023953095,
0.010770399,
-0.017518036,
0.069637254,
0.0038494833,
-0.023076514,
-0.00035377534,
0.009370587,
-0.024462735,
-0.12361836,
-0.012951659,
-0.0028964558,
0.006934506,
-0.010260759,
0.019651731,
0.003951411,
0.024326831,
-0.015710512,
0.030116346,
-0.017151095,
-0.03321496,
-0.006407878,
-0.0048177997,
0.015465885,
-0.0022645018,
0.0051813433,
-0.011320811,
-0.011320811,
0.041070215,
0.013733108,
-0.011864427,
-0.011103364,
-0.02198928,
0.015778465,
-0.019515827,
-0.008099884,
0.038651124,
0.008262969,
0.023497816,
0.010403458,
-0.016824925,
0.0010311722,
0.006373902,
-0.029464006,
-0.03193746,
-0.011225677,
-0.01897221,
0.041722555,
-0.023334732,
-0.0025991655,
-0.0073388205,
-0.0031410833,
-0.011096569,
0.020997182,
-0.00464792,
0.011198496,
0.020385614,
-0.010777194,
-0.003047649,
-0.035063256,
-0.011531462,
-0.026596429,
-0.011443124,
0.012836141,
-0.018578088,
0.0047940165,
0.016661841,
-0.022831887,
0.002023272,
-0.00656077,
-0.008494006,
-0.024449145,
-0.009058007,
0.024109384,
-0.012068283,
-0.02661002,
-0.02463941,
0.02027689,
-0.025713053,
-0.0032124328,
0.0052153193,
-0.016675431,
-0.0024292856,
-0.025971271,
0.0024921412,
-0.03623203,
-0.026868237,
-0.0013666855,
-0.007447544,
0.0014932462,
-0.016566709,
0.016593888,
-0.01592796,
0.008691066,
0.009506491,
-0.0017463675,
0.0024122975,
0.013576819,
-0.013651566,
-0.027330311,
0.03693873,
-0.013495276,
-0.0318831,
-0.030687142,
0.017205458,
-0.0039004474,
-0.013882603,
0.023783214,
0.0134613,
-0.021513617,
-0.00783487,
-0.056264292,
0.016852107,
-0.0041110986,
-0.0002913444,
0.0013046792,
-0.02291343,
0.017028783,
0.002152381,
-0.0055380915,
0.019733272,
-0.024190927,
0.009193911,
-0.01995072,
-0.02624308,
-0.014134025,
-0.029192198,
0.025414065,
-0.0102947345,
-0.005782719,
0.027316721,
-0.013230263,
-0.0134613,
0.00068758975,
0.011252859,
-0.009574443,
-0.002519322,
0.006649107,
0.026433345,
-0.012041102,
0.0037033863,
-0.00073855376,
-0.04126048,
-0.026202308,
-0.002911745,
-0.006958289,
-0.019855587,
-0.010328711,
0.02194851,
0.028730124,
0.022532897,
-0.04028197,
-0.024788905,
0.0032209267,
0.019665321,
-0.012978841,
0.016566709,
-0.025346112,
0.020154577,
0.008996851,
-0.0058608637,
0.038379315,
0.0044440636,
-0.008894922,
-0.019583778,
-0.016457984,
0.0024139963,
0.005310452,
0.0013369564,
0.019488646,
-0.018713992,
0.020032262,
0.010756808,
0.032100543,
0.010179216,
0.013998121,
-0.0077397376,
0.016811335,
0.0016028188,
-0.016553117,
-0.033187777,
-0.027738024,
0.017287,
0.006737445,
0.0023970082,
0.001255414,
0.009717142,
-0.01992354,
0.011565438,
-0.006142865,
-0.006309347,
0.007583448,
-0.010036517,
0.013767084,
0.014745593,
0.02496558,
0.0028149134,
-0.00034804188,
0.02166311,
0.0026501296,
0.007291254,
-0.0007585147,
0.018904258,
0.025903318,
0.0028285037,
-0.010648085,
0.033677034,
-0.0096220095,
-0.0068869395,
-0.0045901607,
0.011844041,
-0.023810396,
0.017789844,
0.0027282746,
-0.03761825,
-0.0038053144,
0.040309153,
-0.018904258,
-0.036014583,
-0.0012579622,
0.017708303,
0.008623114,
0.012170211,
0.017382132,
0.015166896,
0.019760454,
-0.0000065264485,
0.00029665313,
-0.033405226,
-0.012571128,
0.033948842,
0.01895862,
0.014596099,
-0.013094359,
-0.0028964558,
0.039765537,
-0.002213538,
0.039385006,
-0.009581238,
-0.0004523058,
-0.008684271,
0.036395114,
0.0056400197,
-0.036476657,
-0.013869012,
-0.0031835532,
-0.0029304319,
0.001242673,
0.015411523,
-0.027452625,
0.08388,
0.03261698,
-0.012503176,
0.013753493,
-0.031692833,
0.023090104,
0.010532566,
-0.0023630322,
0.020671012,
-0.047049996,
0.0024581652,
-0.01796652,
0.013216672,
-0.03462836,
-0.028730124,
-0.000027313536,
0.0037169768,
0.0048959446,
-0.03182874,
-0.026433345,
0.01263908,
-0.012448815,
-0.012598309,
0.02325319,
-0.013352577,
0.0150853535,
0.006336528,
-0.010654881,
-0.00064851734,
-0.016485166,
-0.008018341,
-0.018102424,
-0.025876138,
-0.011008231,
0.005089608,
0.004484835,
-0.005048837,
-0.004107701,
0.024775315,
0.0117149325,
-0.0030085768,
-0.0066593,
-0.0002320987,
-0.032671344,
0.023919119,
-0.001200203,
0.011572233,
0.011171316,
-0.010525771
] |
Here we show that the relaxation induced by stimulation of the vagus nerve in the presence of cholinergic (muscarinic) and adrenergic blockade in the isolated stomach of the guinea pig is mediated by nitric oxide (NO). This is substantiated by inhibition of vagal relaxation by NG-monomethyl-L-arginine, an inhibitor of NO synthesis. The effect of NG-monomethyl-L-arginine was partially reversed by coincubation with L-arginine but not with D-arginine. NO activates soluble guanylate cyclase, and relaxation of the stomach induced by vagal stimulation was prevented | [
-0.020758612,
0.00074389495,
0.025991876,
-0.022637218,
-0.021349031,
0.01571321,
-0.007876732,
-0.03843094,
-0.03207051,
-0.015686372,
-0.003619674,
0.016598837,
0.004411373,
0.0030040944,
-0.014867836,
-0.012908717,
0.04535495,
0.0034251038,
0.015189882,
0.006367137,
-0.008279291,
0.03912871,
-0.010365888,
-0.024757361,
0.008131687,
0.016048674,
0.010278666,
-0.023804639,
-0.018209074,
-0.0027155941,
0.004096035,
0.014961766,
-0.004907862,
-0.017524723,
0.013029484,
-0.015163045,
-0.0052936473,
-0.000009389106,
0.007916988,
0.014062718,
0.015189882,
-0.0019809243,
-0.0020580816,
0.023415498,
-0.019081283,
0.007474174,
-0.00027151746,
-0.030540789,
-0.024140105,
0.023643615,
0.017967537,
-0.0063839103,
0.009473548,
0.018182235,
-0.017296607,
0.0021805265,
0.013633322,
0.011902319,
0.0001658458,
-0.048146024,
-0.024032755,
0.0008764039,
-0.020959891,
0.011224679,
-0.018947097,
0.0040524243,
-0.005307066,
-0.010124352,
0.012358553,
0.005031984,
0.02740083,
0.026340758,
-0.028018087,
0.0028732629,
0.044308297,
0.002076532,
-0.030889673,
-0.011238097,
-0.012123727,
-0.0068904636,
0.0347274,
-0.04025587,
-0.01501544,
0.041222014,
0.025897944,
-0.022288335,
-0.0076888716,
0.015632696,
-0.014653138,
-0.009681537,
0.034834746,
0.049085326,
0.024126686,
0.0063268812,
0.004612652,
0.017645491,
-0.014478696,
0.0076821623,
-0.01198954,
-0.009493677,
-0.018464027,
-0.023496011,
-0.015995,
-0.009017316,
-0.006273207,
-0.010828829,
-0.012593378,
-0.028152274,
0.025535641,
-0.0141163925,
-0.034646887,
0.010070677,
-0.007843186,
-0.024650013,
0.005273519,
0.00061222474,
0.04591853,
0.020570751,
-0.005733107,
-0.022717731,
-0.0038981102,
0.003686767,
0.03346605,
-0.012928844,
0.026501782,
0.014129811,
0.0060148984,
-0.00541106,
-0.027119039,
-0.00007264927,
0.000626482,
0.017779676,
0.00419332,
0.016612256,
-0.0068133064,
0.031345908,
0.0019490551,
-0.0023767739,
-0.0032607256,
-0.011540017,
0.008044465,
0.038967684,
-0.022087054,
-0.0014315995,
-0.022489615,
0.028715856,
0.018168816,
0.018504282,
0.014478696,
0.0036465111,
-0.013250891,
-0.027588692,
-0.0062564337,
-0.018759236,
0.006296689,
0.027119039,
-0.016733024,
0.02467685,
-0.020436564,
-0.005615694,
0.00692401,
-0.024448734,
0.017833352,
-0.018289585,
0.012995938,
0.02145638,
0.025361199,
-0.011278354,
-0.018853167,
-0.0060652182,
0.000529197,
0.056143522,
-0.017618654,
0.01716242,
-0.004934699,
0.021228263,
0.0051225596,
-0.0054378975,
0.008889838,
0.009815724,
-0.025508804,
0.0032657576,
0.010439689,
-0.0053875777,
0.007715709,
0.015740046,
0.027910737,
-0.0072192196,
-0.014425021,
-0.02534778,
-0.017672328,
0.010124352,
-0.016612256,
-0.023375243,
-0.63121206,
-0.0033378827,
-0.002628373,
-0.0022526516,
0.022516452,
0.015028859,
-0.003851145,
-0.016035255,
-0.0021536893,
0.027561855,
-0.02058417,
0.024462152,
0.024743943,
-0.020731775,
-0.0024925093,
-0.024851292,
-0.0015741723,
0.009138083,
0.029413624,
0.0048038675,
-0.019524097,
-0.016370721,
0.027561855,
0.011419249,
0.029708834,
0.02612606,
0.008131687,
-0.013324694,
-0.012177401,
0.018786075,
0.015820557,
0.0075412667,
-0.0012412227,
-0.009111246,
0.04242969,
-0.029628322,
-0.017685747,
0.014478696,
-0.01755156,
0.017819934,
-0.011580273,
0.0035089701,
0.019349655,
-0.02769604,
-0.01999375,
0.0049917283,
0.022449357,
0.0011615496,
-0.025240432,
-0.014183486,
0.0056727235,
0.004203384,
-0.013479007,
0.017685747,
0.019470423,
0.009802305,
0.01629021,
-0.017242933,
-0.010741608,
0.029601485,
0.018276166,
-0.0054647345,
-0.016357303,
-0.017229514,
0.017135583,
0.020637844,
-0.0116004,
0.0011959348,
0.009158211,
0.0026300503,
0.009386327,
0.029816182,
-0.009647991,
-0.011862064,
0.032634094,
0.047555603,
-0.020745194,
0.039584942,
-0.0058002,
0.007923697,
-0.008178651,
0.022006543,
-0.012264622,
0.024073012,
0.033117164,
-0.016733024,
-0.033734422,
0.014693393,
0.008695268,
-0.020490238,
-0.0011380671,
0.022127312,
-0.022798242,
0.0072930222,
-0.038860336,
0.035425168,
0.0024723816,
0.008688559,
0.013834601,
-0.0226238,
-0.028205948,
0.02184552,
-0.008440315,
-0.020248704,
0.011157586,
0.017484467,
-0.040738944,
0.008668431,
0.034163818,
-0.044657182,
0.011573563,
0.007675453,
-0.012553123,
0.0063537187,
-0.015632696,
-0.024207197,
0.02203338,
0.0118553545,
-0.0019607965,
-0.019550934,
-0.011848645,
-0.021040402,
0.0032271792,
-0.0002572602,
0.0087623615,
-0.0025948265,
0.002883327,
-0.016223116,
-0.019644866,
-0.010131061,
0.0006780598,
0.028984228,
0.029977206,
-0.0040222327,
0.010775155,
0.026971435,
0.041597735,
0.0008021821,
0.009238723,
-0.028850041,
-0.037089076,
-0.0006159987,
-0.0065013235,
-0.008802617,
-0.0057230433,
-0.013203926,
-0.0054848627,
0.006571771,
0.0037505054,
0.0011540017,
0.005666014,
-0.008057884,
-0.01726977,
0.02105382,
0.031828977,
0.001799773,
-0.01696114,
-0.025106246,
-0.010640969,
-0.0024052884,
0.031158045,
0.027320318,
-0.024126686,
0.0011875483,
-0.04575751,
-0.019550934,
0.011224679,
0.018007794,
-0.007131999,
-0.030594463,
0.015431418,
0.0029739025,
0.010828829,
0.011271644,
0.005763299,
-0.0016966172,
-0.008051175,
-0.0028967455,
-0.019913238,
0.005239973,
-0.006320172,
-0.014478696,
-0.006494614,
-0.0022929073,
0.035827726,
0.007138708,
0.012982518,
0.017766258,
-0.010017003,
0.02691776,
0.0013133478,
0.006058509,
-0.025186757,
0.019376494,
-0.026166316,
-0.03727694,
0.024354802,
-0.0024723816,
0.005914259,
0.02350943,
0.017028233,
0.016894048,
0.012123727,
0.000023928133,
0.022972684,
0.003180214,
0.009312525,
-0.019913238,
0.011204551,
-0.0073064407,
0.007829767,
0.008044465,
-0.01824933,
-0.015297231,
0.012586669,
0.0116876215,
-0.013244182,
-0.005615694,
0.011667494,
-0.011419249,
0.014478696,
0.0033580107,
0.010318922,
0.016746443,
-0.0372501,
0.031855814,
0.0026149543,
0.000021818369,
-0.018007794,
-0.025146501,
-0.029977206,
0.02175159,
-0.0048944433,
-0.006135666,
0.005548601,
0.03601559,
-0.0017679037,
0.0056022755,
0.023482593,
0.019322818,
0.0011623884,
0.008695268,
0.013794346,
0.0058538746,
0.017645491,
-0.0001702488,
0.0057196887,
-0.01004384,
-0.015847394,
0.017564978,
0.009325944,
0.028286459,
-0.014022462,
-0.008332966,
0.0084872795,
0.0067462134,
0.024234036,
0.011888901,
0.028903715,
0.015216719,
0.011774843,
0.0066086724,
0.013438752,
-0.03384177,
-0.016746443,
0.019644866,
0.0076888716,
0.021013565,
-0.00946013,
-0.007568104,
-0.011694331,
0.0063906196,
0.0126269255,
-0.018423771,
0.022006543,
-0.0024941869,
-0.0014466954,
0.021214845,
0.018450608,
-0.00062186935,
-0.011788261,
-0.024891548,
0.04006801,
-0.005578793,
0.008078012,
0.0057565896,
-0.014934928,
0.0040490697,
-0.010842248,
0.012512867,
-0.019067865,
0.012948972,
0.010184736,
-0.0039752675,
-0.020449983,
-0.008594628,
0.012975809,
-0.011533308,
0.025039153,
-0.008883129,
0.0101981545,
0.011378993,
-0.028071761,
0.0062463693,
0.013720543,
0.016558582,
-0.004263768,
-0.007239348,
0.012989228,
-0.007903569,
0.0278839,
0.015726628,
-0.0050823037,
-0.027199551,
-0.0016538454,
0.022677476,
-0.023482593,
0.004709937,
0.038887173,
-0.017578397,
-0.011264935,
-0.04221499,
0.005759944,
-0.02573692,
0.01773942,
-0.008594628,
0.0031416353,
0.019779053,
0.017323444,
-0.009473548,
-0.017833352,
-0.022019962,
0.022798242,
-0.013492427,
0.00010944565,
0.012512867,
0.007480883,
0.008661722,
0.022838498,
-0.0019222179,
-0.0013779249,
-0.02136245,
-0.024234036,
-0.0116876215,
0.0034854875,
0.032714605,
-0.004079262,
0.018209074,
-0.008520827,
0.014049299,
0.020221867,
0.01716242,
0.023482593,
-0.0372501,
0.024113268,
0.009580897,
0.004143,
-0.011130748,
-0.03244623,
-0.040041175,
-0.0006126441,
0.03695489,
0.008822746,
-0.0035961913,
0.0024254164,
0.023428917,
-0.003103057,
-0.003482133,
0.0047535477,
-0.019792471,
-0.00087724254,
0.008084721,
-0.021697914,
0.00082398736,
0.015176464,
-0.0104195615,
0.0067629865,
-0.013324694,
0.03158744,
0.009775467,
-0.021389287,
-0.0029151961,
-0.016639093,
-0.013076449,
-0.015646115,
-0.016062094,
0.033707585,
-0.019457005,
0.002428771,
-0.034673724,
-0.017377118,
-0.016894048,
-0.028689018,
0.0014542434,
0.019658284,
-0.021523474,
-0.018370096,
-0.0025814078,
0.016545163,
0.006638864,
0.013693706,
0.007467464,
-0.0065583526,
0.033278186,
-0.013076449,
-0.031855814,
-0.005666014,
-0.020825705,
0.020262122,
0.004250349,
0.0044046636,
0.0077693835,
0.0016907466,
-0.032124188,
0.0333587,
-0.024207197,
0.031265393,
-0.03432484,
0.011902319,
-0.0028112018,
0.020141354,
0.0092051765,
0.0061625033,
0.007668744,
-0.0007535396,
-0.034002792,
-0.0028984228,
-0.021630822,
-0.014908091,
-0.009896236,
0.0073668244,
0.0020010523,
0.0002731948,
-0.0073668244,
0.01824933,
-0.010392725,
-0.011177714,
0.019564355,
0.011868773,
0.032016836,
-0.009916363,
0.04653579,
-0.013311275,
-0.014800742,
-0.011640657,
0.025884526,
0.034646887,
0.008708687,
-0.02195287,
0.023227638,
-0.0048508327,
-0.0024790908,
-0.02944046,
0.008493989,
-0.005783427,
0.013143542,
-0.0057062698,
-0.03899452,
-0.031104371,
-0.006897173,
-0.015283813,
0.0024220617,
-0.025790596,
-0.02486471,
-0.015726628,
-0.0020027296,
0.0017595171,
0.015230138,
0.035988748,
-0.027481342,
-0.009983457,
-0.016303629,
-0.032902468,
0.010949598,
-0.008567791,
-0.00030946702,
-0.0087355245,
-0.007225929,
-0.028984228,
-0.026193155,
-0.026864085,
-0.022583544,
-0.0013577971,
0.031050697,
0.049890444,
-0.007474174,
-0.00672944,
0.017712584,
-0.0000876928,
0.0193094,
-0.03268777,
0.027535016,
-0.036391307,
0.035049446,
0.0077693835,
-0.005139333,
0.016048674,
-0.024274291,
0.011452796,
0.015297231,
0.0002522282,
0.0013611517,
-0.0026384369,
-0.023536267,
-0.00648455,
0.03247307,
-0.01501544,
0.00057322683,
-0.02145638,
-0.028018087,
0.024851292,
0.0025780532,
0.011238097,
-0.030594463,
-0.013888276,
-0.023160545,
0.029467298,
0.009319235,
-0.00058874214,
-0.014787324,
-0.015324068,
0.007735837,
0.004240285,
-0.024784198,
-0.006846853,
0.017645491,
0.012425646,
-0.025227014,
-0.009956619,
-0.008225617,
0.0033714294,
0.011258226,
-0.021442961,
-0.018182235,
-0.036686517,
0.00012695276,
0.001587591,
-0.030889673,
0.010030421,
0.02935995,
-0.021080658,
-0.0025143146,
-0.035452005,
-0.0083195465,
-0.008534245,
-0.029145252,
0.015498511,
-0.016625674,
0.025804015,
0.003579418,
-0.0092051765,
0.0015716563,
0.009741921,
0.0005044564,
-0.004904507,
0.022100475,
-0.009030734,
-0.0012965746,
-0.024998896,
-0.01423716,
0.027293481,
-0.017283188,
-0.01384802,
0.04339583,
0.014787324,
0.007360115,
-0.020637844,
-0.011613819,
0.0004960698,
0.01033905,
0.017028233,
-0.0024925093,
-0.020181611,
0.0054781535,
-0.026381016,
0.008212198,
0.007937117,
0.026689643,
-0.004280541,
0.0024623175,
-0.009762049,
0.0077492553,
-0.030272417,
0.016236534,
-0.025441712,
0.025817433,
-0.008863001,
0.0026048904,
-0.014143229,
0.03572038,
0.023093453,
-0.002833007,
0.0007099291,
0.036069263,
0.0027558499,
-0.012298169,
0.013888276,
-0.02545513,
0.031721625,
-0.033305027,
-0.00458246,
-0.010547038,
-0.025428293,
-0.0068133064,
0.01569979,
0.028823204,
-0.021147752,
-0.0028061697,
-0.012110308,
-0.010439689,
-0.024757361,
-0.0022593609,
0.008534245,
-0.017189257,
-0.01423716,
-0.02330815,
-0.010345759,
0.0070850337,
-0.0064510037,
0.006444294,
-0.0047535477,
0.01638414,
-0.01590107,
0.007333278,
-0.004703228,
0.008802617,
-0.014304253,
-0.0038813371,
0.008359803,
-0.018705562,
0.020168193,
-0.018034631,
-0.03188265,
-0.020906216,
0.0020597589,
0.008124976,
0.00018796558,
-0.0046260706,
0.021765009,
0.026152898,
0.016531745,
0.015726628,
-0.00270553,
0.018410353,
0.0027759778,
-0.00750772,
0.0061625033,
-0.017900445,
-0.0069105914,
-0.008004209,
-0.007440627,
0.030540789,
0.0021033692,
-0.02397908,
-0.037706334,
-0.012881879,
-0.030862836,
-0.025388036,
-0.00443821,
-0.019121539,
-0.033170838,
0.02584427,
0.002883327,
-0.004096035,
-0.014867836,
0.0016144282,
0.009003897,
-0.005676078,
-0.0212551,
0.017242933,
0.017497886,
-0.0014047622,
-0.03139958,
-0.022127312,
-0.021657659,
0.025522223,
-0.008312837,
-0.005578793,
-0.0036465111,
0.016719606,
-0.028393809,
0.012096889,
-0.018611632,
0.016223116,
0.015914489,
0.01667935,
-0.025468549,
-0.02379122,
-0.010292085,
-0.00001594772,
0.0014643073,
0.0055922116,
0.022717731,
0.0043912446,
0.02526727,
0.0042436398,
-0.023442335,
-0.011392412,
0.021671077,
-0.019658284,
-0.020879379,
0.018960515,
-0.0041463547,
0.008748943,
-0.022248078,
-0.0032506618,
0.011097202,
-0.0037874067,
0.028635344,
-0.023039777,
-0.02360336,
0.007977372,
0.003589482,
-0.019269144,
0.013411915,
-0.0037102494,
0.022583544,
0.006601963,
-0.032553583,
-0.019255726,
0.017632073,
-0.007286313,
0.0023029714,
0.033734422,
-0.0047971583,
0.00031911166,
-0.0017393891,
-0.003175182,
-0.031077534,
0.0007417983,
-0.022073636,
0.011070365,
0.022825079,
-0.011224679,
-0.022194404,
0.0065851896,
0.0005895808,
-0.021832101,
0.018209074,
0.008171942,
-0.0010139447,
-0.004096035,
0.00897035,
0.026770156,
0.015485092,
0.004703228,
0.004428146,
-0.0043342155,
-0.0107214805,
-0.021872357,
-0.0130965775,
-0.020517075,
-0.0056425314,
0.005384223,
-0.013411915,
0.012150564,
-0.0038846917,
-0.019269144,
-0.016021837,
0.021791846,
0.17347597,
0.009876107,
-0.0099230725,
0.014156648,
-0.008554373,
-0.009352781,
-0.0031936325,
0.005914259,
0.010909341,
-0.0067059575,
0.0036532204,
0.013177088,
-0.0050890134,
-0.0062564337,
-0.005001792,
-0.017310025,
-0.028286459,
-0.02214073,
0.0054580253,
-0.0060014795,
0.0055821477,
-0.005696206,
-0.0008713719,
-0.004612652,
0.026998272,
-0.023831476,
-0.020879379,
-0.0016932626,
0.025924781,
0.026958015,
-0.017323444,
0.005297002,
-0.00090240245,
0.013230763,
-0.00022350396,
0.00042394464,
-0.0050252746,
-0.008534245,
0.003482133,
0.009647991,
0.0017460985,
0.0045455587,
-0.033975955,
-0.0014072782,
-0.031050697,
0.01667935,
-0.008440315,
-0.0022056864,
-0.0038981102,
0.017189257,
-0.047770303,
0.0060216077,
0.030755486,
0.008648303,
0.031963162,
-0.02116117,
0.021671077,
-0.00030569304,
0.011070365,
0.033895444,
-0.018168816,
0.013794346,
-0.0026870794,
0.010178027,
-0.0140895555,
0.025119664,
0.001155679,
-0.0037471508,
0.007970663,
-0.013472298,
0.008997187,
-0.023133708,
-0.0121841105,
0.011050237,
-0.024421895,
-0.007970663,
0.017578397,
0.017242933,
0.01706849,
0.006279916,
-0.014572626,
-0.0016228148,
-0.019537516,
-0.009822433,
-0.018356677,
-0.018209074,
0.004944763,
0.02116117,
-0.019577773,
-0.012083471,
-0.0016831986,
-0.011862064,
-0.02086596,
-0.013170379,
0.018544538,
-0.0074943015,
0.010265247,
-0.010292085,
0.0019591192,
0.011694331,
-0.018987354,
0.080028675,
-0.0077693835,
0.006018253,
-0.018423771,
0.0050386935,
0.0050890134,
0.019403331,
-0.015203301,
0.0116339475,
-0.015780302,
0.012861751,
0.008353094,
-0.022368846,
-0.020570751,
0.021281937,
0.02195287,
-0.016464652,
0.017095327,
-0.022274915,
-0.018544538,
-0.00045371722,
-0.0097285025,
-0.0007795382,
-0.008044465,
-0.014102974,
-0.011754715,
0.0025629571,
0.009936491,
-0.031963162,
-0.0030409957,
-0.01199625,
-0.014277416,
0.012036506,
0.0048642512,
0.01921547,
0.00048852176,
-0.0022409102,
0.01510937,
-0.0010080741,
0.018973934,
0.0005908388,
0.02389857,
-0.00014970152,
0.01812856,
0.003399944,
0.015350906,
-0.010788574,
-0.029198926,
-0.005343967,
-0.008232326,
-0.028286459,
0.016504908,
0.0035626446,
0.014344509,
-0.023844896,
-0.019041028,
-0.045193925,
-0.0076419064,
0.017497886,
-0.007360115,
-0.008836164,
0.047528766,
-0.020758612,
-0.0087623615,
-0.006709312,
-0.16875261,
0.037223265,
0.029172089,
-0.01345888,
0.039450753,
0.0092320135,
0.021966288,
0.023724128,
-0.020691518,
0.0007132837,
0.0013468944,
0.0006118054,
-0.029413624,
-0.037223265,
0.0052500367,
0.035774052,
-0.023496011,
-0.011835227,
-0.012096889,
0.011808389,
0.0278839,
-0.017014815,
0.034968935,
-0.035210468,
-0.022959266,
0.0126805995,
-0.014478696,
-0.0054244786,
-0.01804805,
-0.0055955662,
-0.031211719,
0.023348406,
0.0049984376,
-0.018034631,
0.024448734,
0.015136208,
-0.0037907613,
-0.029145252,
-0.0050353385,
0.027588692,
0.022717731,
0.02389857,
-0.011144168,
0.0012278041,
-0.025871107,
0.0012261268,
0.02495864,
0.00011374381,
0.016410977,
-0.011969413,
0.013479007,
-0.010406143,
0.012137146,
0.011023399,
0.0076083597,
0.008930095,
0.0029135188,
0.0036398019,
-0.0007728289,
-0.015069115,
0.016800117,
-0.00672944,
0.018987354,
0.025830852,
-0.01247932,
-0.0358814,
-0.018450608,
-0.016826954,
-0.01775284,
0.012110308,
-0.031963162,
-0.0048810244,
0.013271019,
-0.02652862,
0.021241682,
0.010493364,
0.0037806972,
0.011332028,
-0.028501157,
0.029091576,
0.000117308125,
0.009017316,
-0.03625712,
-0.022368846,
-0.0027608818,
0.020557333,
0.009131374,
0.012029797,
-0.006897173,
0.013539392,
0.01969854,
-0.023630196,
0.008621466,
-0.036230285,
0.008842873,
-0.0014274061,
0.015216719,
-0.0044214367,
-0.0071051614,
-0.016062094,
0.02573692,
-0.009809014,
-0.010540329,
0.015646115,
0.025307525,
0.014210323,
-0.012023088,
0.012808077,
0.033170838,
-0.009117955,
-0.0031986644,
-0.00017056329,
0.010245119,
0.026367595,
-0.037384287,
0.029037902,
0.013861438,
-0.019792471,
0.0027877192,
-0.00560563,
0.03547884,
0.014518951,
0.012170692,
-0.015592441,
-0.007937117,
-0.043530017,
-0.13579647,
-0.050588213,
0.01286846,
0.01902761,
-0.016478071,
0.009634572,
0.008332966,
0.010063968,
0.011841936,
0.029520974,
0.009238723,
0.013821183,
0.003686767,
-0.0064040385,
0.026676225,
0.0045388495,
0.005907549,
-0.0068133064,
-0.02214073,
0.03190949,
-0.02448899,
-0.012640344,
-0.0028497803,
0.00047258715,
-0.0032758217,
0.0066724108,
-0.0060417354,
0.037813682,
0.0021553666,
0.00526681,
0.027186133,
-0.013834601,
0.02360336,
-0.02086596,
-0.047153044,
-0.010426271,
0.008809327,
-0.01775284,
0.04895114,
-0.0031886005,
0.0112179695,
-0.0017175839,
0.019537516,
-0.0015272072,
0.005578793,
-0.014277416,
-0.021590566,
0.011707749,
0.0016429428,
-0.0014114715,
-0.015820557,
-0.0087623615,
-0.012861751,
0.015927907,
0.048682768,
0.005998125,
0.01510937,
0.038243078,
-0.021738172,
-0.004320797,
-0.0027139168,
-0.0102249915,
-0.010057258,
-0.0065180967,
0.015485092,
0.023080034,
-0.0069173006,
-0.02526727,
0.026568877,
-0.017819934,
-0.007856605,
-0.0009569156,
0.005441252,
-0.0021922677,
-0.03628396,
0.02799125,
-0.013472298,
-0.00080931076,
0.011761424,
0.0010701353,
-0.016142605,
-0.02495864,
0.005042048,
0.017403955,
0.0014257288,
0.006531515,
0.012137146,
0.0050554667,
0.003891401,
-0.018222492,
-0.028689018,
0.024811035,
0.0020882734,
-0.01784677,
-0.0060887006,
0.018423771,
0.009621154,
-0.011009981,
0.022127312,
-0.008963641,
0.001989311,
-0.034834746,
-0.045703832,
-0.0010282021,
0.002101692,
-0.000636546,
-0.01501544,
-0.004290605,
0.029601485,
-0.0011439377,
0.019510679,
-0.02078545,
-0.05031984,
0.012070052,
-0.006165858,
-0.0050185653,
-0.026461527,
-0.03166795,
0.028823204,
-0.008460443,
0.007501011,
0.0018568021,
-0.004300669,
0.0128483325,
0.0015372711,
0.010620841,
-0.00023985791,
0.006903882,
-0.038752988,
0.009507095,
-0.011748006,
-0.019148376,
0.0038041798,
-0.056411896,
-0.0025327653,
-0.010949598,
-0.022180986,
-0.0031466673,
-0.019483842,
0.029118415,
0.017819934,
0.027508179,
-0.018101724,
-0.024998896,
-0.0027910739,
0.002802815,
0.009929782,
-0.0046562627,
-0.0198864,
0.026635969,
-0.0036599296,
-0.023039777,
0.025307525,
-0.010184736,
0.0007782802,
-0.021080658,
-0.017779676,
-0.002608245,
0.008634885,
0.0065751257,
-0.0032338884,
-0.0037471508,
0.03325135,
-0.0059410958,
0.020248704,
0.0025126373,
-0.00025809885,
0.0031366034,
-0.028366972,
-0.009694956,
0.04009485,
0.00251096,
-0.026193155,
-0.037625823,
-0.008909967,
-0.0025545706,
0.008212198,
0.0037471508,
-0.0049212803,
-0.0021905904,
0.0018450608,
0.0034653596,
0.010164607,
-0.011868773,
-0.021496635,
0.019188633,
0.026810411,
0.034673724,
0.009386327,
0.01688063,
0.023657035,
0.00916492,
-0.012002959,
0.0035156794,
0.012056634,
0.0072930222,
0.005753235,
0.021000147,
-0.001065942,
-0.008272582,
0.014465277,
0.023965662,
0.024985477,
0.018906841,
-0.00024090623,
-0.021765009,
0.007655325,
0.026166316,
-0.02613948,
-0.041490387,
-0.021214845,
-0.002311358,
0.024730524,
0.0055754385,
-0.0031382807,
0.005468089,
-0.00013219441,
0.0173637,
-0.026796993,
-0.018316422,
-0.006303399,
0.03346605,
0.009513805,
0.020101098,
0.004173192,
0.0042537036,
0.0029487426,
-0.020530494,
0.052037425,
-0.021697914,
0.01853112,
-0.02643469,
0.0020899507,
0.0037001856,
-0.030701812,
-0.020745194,
-0.012586669,
-0.022704313,
-0.0016915853,
0.020329215,
-0.02495864,
0.079330906,
0.009493677,
-0.0012915425,
0.008453733,
0.0069173006,
0.026783574,
-0.006736149,
0.014908091,
-0.008151814,
-0.020423146,
0.021697914,
-0.01735028,
0.030997021,
-0.025871107,
-0.022180986,
0.009835851,
-0.0015272072,
0.010292085,
-0.008863001,
-0.04484504,
0.010184736,
-0.0074540456,
-0.014156648,
0.017927282,
-0.01980589,
0.0025696666,
0.02671648,
-0.01004384,
0.0039014649,
-0.026407853,
-0.010372597,
0.029574648,
-0.03462005,
0.002848103,
-0.0041899653,
-0.009547351,
-0.0069978125,
-0.009252141,
0.006605318,
0.025683247,
-0.0087891985,
0.021805264,
-0.024260873,
-0.0024774135,
-0.004934699,
-0.00482735,
-0.025213595,
0.008500698,
-0.02408643
] |
Cytotoxic T cell (CTL) activation by antigen requires the specific detection of peptide–major histo-compatibility class I (pMHC) molecules on the target-cell surface by the T cell receptor (TCR). We examined the effect of mutations in the antigen-binding site of a Kb-restricted TCR on T cell activation, antigen binding and dissociation from antigen. These parameters were also examined for variants derived from a Kd-restricted peptide that was recognized by a CTL clone. Using these two independent systems, we show that T cell activation can be impaired by mutations that either decrease or increase the binding half-life of the TCR | [
-0.030814782,
-0.00011273599,
0.001565336,
-0.013660506,
0.006846986,
0.025393415,
-0.023827242,
0.004216619,
-0.028726552,
-0.0035774328,
-0.00008366307,
0.009082463,
0.004132956,
0.009283254,
-0.008761196,
0.0019962008,
0.030948643,
-0.004852458,
-0.018780686,
-0.011565583,
-0.021739012,
0.016679069,
0.0072418754,
-0.027655665,
-0.008861592,
0.012596312,
0.011558889,
-0.06393197,
-0.016331032,
-0.011900235,
0.019342901,
0.012375441,
-0.031617947,
0.0014549008,
-0.019021636,
0.004045946,
0.025460346,
-0.0025266248,
0.031725038,
0.024750883,
0.021913031,
0.00984547,
0.008486782,
0.0041128765,
0.014483751,
0.0013904802,
-0.0012198075,
-0.0069072233,
-0.027361171,
0.019731099,
0.016157012,
-0.0030369693,
0.0033716217,
-0.0018171619,
-0.02797693,
-0.021658696,
0.002066478,
0.015621568,
-0.0013285696,
-0.032956555,
-0.0128305685,
0.007000926,
-0.005063289,
0.011880156,
0.018660212,
0.0059768897,
0.013841218,
0.01773657,
-0.013084904,
0.00057560194,
-0.004788874,
0.018191699,
-0.007422588,
0.0044977264,
0.03167149,
-0.009397036,
-0.016250715,
-0.0062044533,
-0.0072284895,
0.018111382,
0.017401919,
-0.02048072,
0.002759208,
0.040158276,
0.019235814,
0.01637119,
0.0213642,
-0.010334062,
0.013975079,
0.0027826338,
0.0102002015,
0.015434164,
0.021993348,
0.030573832,
-0.014952264,
0.025554048,
0.00720841,
0.02263588,
-0.0064420565,
-0.025005218,
-0.018044451,
0.016705843,
-0.013138449,
-0.022475246,
-0.033920355,
0.0017167662,
-0.0030520288,
-0.010909664,
0.007817477,
-0.008071813,
-0.019476762,
0.015487707,
-0.021283885,
-0.04634265,
0.013024666,
0.016210556,
-0.0006266364,
-0.0007688636,
-0.0037146404,
0.0039087385,
0.028726552,
0.014617612,
0.009002146,
-0.013600268,
0.034910925,
0.003500463,
-0.0152199855,
-0.016264101,
-0.015005808,
-0.0082190605,
0.027789526,
0.03068092,
-0.0038116896,
-0.0005914979,
-0.007476132,
0.008901751,
-0.03180535,
0.008955295,
0.001753578,
-0.019476762,
-0.013519952,
0.035607003,
0.005267427,
-0.00044634248,
0.015634954,
0.018579895,
0.020614581,
0.014028624,
0.0021334083,
0.0068670646,
-0.022274455,
-0.012750252,
0.0010474616,
-0.0036644426,
0.016264101,
0.008373,
0.0012072581,
0.01742869,
0.0019292705,
-0.031323455,
-0.009791926,
-0.011585662,
0.018231856,
-0.008152129,
0.02428237,
0.022983918,
0.013760902,
0.0034469184,
0.006331621,
-0.007790705,
-0.0021200222,
0.028378513,
0.0022605762,
0.016317645,
-0.018111382,
0.0035607002,
-0.005257387,
0.020976005,
-0.009631293,
-0.0038618874,
-0.014162485,
0.0028579305,
0.021551607,
0.007034391,
0.00035745048,
0.015621568,
0.015835745,
-0.016518436,
-0.0024463083,
-0.023131166,
-0.00007273458,
-0.0021551608,
-0.0111974655,
-0.032073073,
-0.6442458,
-0.008948602,
0.029128134,
-0.0085670985,
-0.019597238,
0.03325105,
0.024054807,
0.010434458,
-0.01503258,
0.027280854,
0.002412843,
0.024670566,
0.00021982472,
-0.022930374,
-0.028673008,
-0.03568732,
-0.011538811,
-0.01975787,
0.031216364,
0.01186677,
-0.009986024,
-0.008480089,
0.0026136343,
0.025446959,
-0.030948643,
-0.0022957146,
0.0042333514,
0.009945866,
0.012636471,
0.03129668,
-0.019650782,
0.0035607002,
-0.0095041245,
-0.009858856,
0.04931436,
0.01681293,
0.009865549,
0.013546725,
0.014202643,
0.039087385,
0.009825391,
0.00029930464,
0.020293314,
0.01606331,
-0.010795883,
0.014925492,
-0.018539736,
0.0120140165,
0.00092531356,
-0.009182858,
0.011358098,
0.023613065,
-0.024857972,
0.021792557,
0.009724995,
-0.00018437249,
0.021056322,
-0.0051369127,
0.0017251325,
0.011532118,
-0.0034904233,
0.019369675,
-0.014470365,
-0.031377,
-0.0066595804,
-0.0021919725,
0.0060973647,
0.027013132,
-0.0028780096,
0.0018807459,
0.007462746,
0.015072739,
-0.018887775,
0.0064989473,
0.0034067603,
0.034268394,
0.0043939846,
-0.017803501,
0.008881671,
0.026999746,
-0.0067030853,
-0.008312763,
-0.02465718,
0.007917873,
0.0155680245,
-0.021390975,
-0.022488633,
0.02784307,
0.010160043,
0.018191699,
0.019811414,
0.0050699823,
-0.010340756,
-0.04023859,
-0.03582118,
0.021672081,
-0.02380047,
-0.013285696,
-0.006037127,
-0.024148509,
-0.009678144,
-0.0036209377,
0.0124222925,
0.0020899035,
0.031725038,
-0.010441151,
-0.026825726,
-0.008239139,
0.0655383,
-0.011826612,
-0.0036778285,
-0.0138144465,
-0.008721039,
-0.009122621,
0.0026805648,
-0.023104394,
0.03102896,
0.026772182,
-0.00013323344,
-0.022903603,
0.023024077,
0.009517511,
0.009069077,
-0.034402255,
0.0149790365,
0.009711609,
-0.0059434245,
-0.006368433,
0.0067800554,
-0.011786453,
-0.001123595,
-0.016237328,
0.01380106,
-0.008587178,
0.02441623,
-0.0023927637,
0.015420777,
0.0072686477,
0.0012624757,
-0.016786158,
-0.040800806,
-0.021872872,
-0.0034101068,
0.00045931025,
-0.016866475,
-0.008245832,
-0.019088566,
-0.0112577025,
0.0025751493,
-0.0072017172,
0.033545546,
0.006214493,
-0.005391248,
0.006144216,
-0.0045546177,
-0.008225753,
-0.016585367,
-0.0061910674,
0.010896279,
-0.02226107,
-0.0061107506,
0.013506566,
-0.0011194119,
0.0028847028,
-0.014684542,
0.00010348076,
0.018686984,
0.008406465,
-0.009678144,
-0.038819663,
0.003289632,
-0.031751808,
-0.029824212,
0.005702475,
0.0046817856,
0.008225753,
-0.01766964,
-0.02202012,
-0.008895057,
-0.0034603046,
-0.004397331,
-0.032903012,
0.017000336,
-0.005963504,
0.034803838,
-0.003922125,
-0.005217229,
0.013747516,
-0.008379693,
0.042755175,
0.008265912,
0.0032009492,
-0.029556489,
0.017964134,
0.006184374,
-0.010822655,
0.018606666,
0.025259554,
0.0030838207,
0.02564775,
-0.001488366,
0.010347448,
0.032474656,
-0.021698855,
0.023505976,
-0.009684837,
-0.008045041,
-0.028860413,
0.018446034,
0.019128725,
-0.00037020908,
0.022649266,
0.008533633,
-0.0009780213,
0.012341976,
-0.004219965,
-0.010782496,
0.008132051,
-0.0066562337,
-0.033652633,
0.007978111,
0.009885629,
0.013908149,
-0.022328,
-0.0034201464,
-0.0013770942,
0.0121813435,
0.013540031,
-0.0014247821,
-0.007308806,
-0.02202012,
-0.01883423,
0.019128725,
0.013218765,
0.017816888,
0.009182858,
0.014831789,
0.0054949904,
0.050412018,
-0.00083244755,
0.0009863876,
0.02164531,
-0.019583851,
0.0027157033,
0.0022890216,
-0.012589619,
0.00682356,
0.0155680245,
-0.0053611295,
0.01404201,
-0.007884407,
0.008754504,
-0.025072148,
-0.003174177,
-0.0047319834,
0.012522688,
0.025781611,
0.015621568,
0.047761574,
0.011157307,
0.018272014,
-0.0061542555,
0.003858541,
-0.014805017,
-0.0064956006,
0.016277486,
-0.008667494,
-0.012743559,
-0.0032009492,
0.015501094,
-0.007094628,
-0.007643458,
-0.00051620114,
-0.033438455,
-0.010039569,
0.028780097,
0.0033900277,
0.015782202,
0.013238844,
0.010126578,
-0.017241286,
-0.029342312,
0.031564403,
0.031484086,
-0.0106084775,
-0.020641353,
-0.032233708,
-0.01459084,
-0.008212367,
0.0203067,
-0.0029984845,
0.00084332377,
0.009370264,
0.0020330127,
-0.0014013564,
-0.018579895,
0.035392825,
0.007462746,
0.016237328,
0.011117149,
-0.015300303,
-0.0011662632,
-0.017134197,
-0.0022622494,
0.0349377,
0.021283885,
-0.0013101636,
-0.019717712,
-0.0020765173,
-0.019945277,
0.024068192,
0.007931259,
0.003835115,
-0.0073690433,
0.0006186884,
-0.0028913957,
0.010447844,
0.024911515,
0.0062881163,
-0.013392785,
-0.012589619,
-0.017575938,
0.016558595,
-0.011110456,
0.0085670985,
0.02153822,
-0.009330106,
0.008654108,
-0.004129609,
0.008841514,
-0.0072284895,
-0.02236816,
0.031617947,
-0.022863444,
-0.031751808,
0.003379988,
-0.0035941654,
-0.0085670985,
0.009644679,
0.020708283,
0.016023152,
0.0017937362,
-0.01962401,
0.0061074044,
0.014242801,
-0.006893837,
0.028994273,
0.021337429,
0.013841218,
-0.0017117464,
0.020775214,
0.030520288,
0.018620053,
-0.016237328,
0.0035607002,
0.024295755,
0.013158528,
-0.001712583,
0.0095643625,
-0.026491074,
-0.007034391,
0.018004293,
0.0019476763,
-0.004594776,
0.02907459,
0.00938365,
0.0066595804,
0.0014774898,
0.0119537795,
-0.0040425994,
0.025139078,
0.0053109317,
-0.0061207903,
-0.026143037,
0.021993348,
-0.022997305,
-0.030948643,
-0.012930964,
0.003674482,
0.008961988,
-0.009684837,
-0.013653813,
0.008071813,
-0.004972933,
-0.0013076538,
-0.018138153,
0.020748442,
0.0043103215,
-0.022060279,
0.0024563477,
-0.00441741,
-0.004685132,
-0.044120558,
-0.0026286936,
0.007315499,
-0.0032662062,
-0.0031758503,
-0.0025115653,
0.001075907,
0.0011386544,
0.00806512,
0.0055585746,
0.014617612,
0.043317392,
-0.027347784,
0.00302693,
-0.019101953,
-0.03458966,
0.0127100935,
0.01955708,
0.0028897224,
-0.021792557,
-0.008774583,
0.01746885,
-0.017147582,
0.0005203843,
-0.0054247137,
-0.0010047934,
-0.0037146404,
0.018539736,
0.0018539736,
0.022836672,
-0.019222427,
-0.007422588,
-0.027254082,
-0.01410894,
-0.0063985516,
-0.011344712,
-0.0064989473,
-0.027816297,
-0.012000631,
0.014805017,
-0.0031139394,
-0.007864329,
0.017495621,
-0.02109648,
-0.006003662,
-0.010327369,
0.02263588,
0.015715271,
0.0074493596,
0.0028863759,
0.012549461,
-0.019744484,
-0.020828757,
-0.036276307,
0.016866475,
-0.0075832205,
-0.020721668,
0.0064487495,
-0.016772773,
-0.021042936,
0.007596607,
-0.02619658,
-0.027053291,
0.021913031,
0.01551448,
-0.004792221,
-0.0017418651,
0.001001447,
-0.011003367,
0.017415306,
0.025406802,
-0.022073664,
-0.032474656,
0.024094963,
-0.0018004293,
-0.004199886,
0.016558595,
-0.0349377,
-0.021270499,
0.03651726,
-0.0034218195,
0.005223922,
0.007770626,
-0.009189552,
-0.020882303,
-0.016920019,
-0.03054706,
-0.042514227,
0.0033883543,
-0.015742043,
0.042969353,
0.028565919,
0.035392825,
-0.010929744,
0.035660546,
0.017575938,
0.0016925039,
0.00682356,
-0.0017569244,
0.032099847,
-0.019302744,
-0.0019041714,
-0.0030771277,
-0.013084904,
0.036088903,
-0.017897204,
0.015782202,
0.008486782,
-0.010722259,
-0.017415306,
0.005300892,
-0.03887321,
-0.015300303,
0.034991242,
-0.0039823623,
0.012549461,
-0.0344558,
-0.00027504234,
0.033411685,
-0.0010600111,
-0.0075363694,
0.0039790156,
0.037373967,
-0.01417587,
0.020935846,
-0.023211483,
0.010360834,
-0.0037849173,
-0.018700369,
-0.00084374205,
0.0071080145,
0.021417746,
0.00605386,
-0.0044508753,
0.014269574,
-0.0033063646,
-0.0135266455,
-0.005090061,
-0.015045967,
-0.020373631,
-0.025594207,
-0.009236403,
-0.012549461,
-0.025768226,
-0.019570466,
-0.0067934413,
0.00058982463,
0.012074254,
-0.0047018644,
0.015715271,
0.0034803837,
-0.020976005,
0.03646371,
0.0024028034,
0.027521804,
-0.036758207,
0.016143626,
-0.0060137017,
0.006395205,
-0.029101362,
-0.011599048,
-0.0050733285,
0.028646234,
0.03276915,
0.02160515,
0.0052440013,
-0.012522688,
-0.0031440582,
0.008018268,
-0.015875904,
-0.03665112,
0.0107289525,
-0.003905392,
0.0054849507,
-0.018245243,
-0.017094038,
-0.012529382,
0.013479793,
-0.008473395,
0.0073221917,
0.012194729,
-0.014068782,
-0.024791041,
0.019543692,
-0.0033281168,
0.0024479814,
0.023077622,
-0.015059353,
0.003898699,
-0.021685468,
0.0076568443,
0.0032176818,
-0.0026721985,
0.020694897,
-0.005250694,
-0.0012725153,
0.009209631,
-0.0046550133,
0.0067365505,
-0.00042333515,
0.0027692476,
0.04037245,
-0.008787969,
-0.009336798,
0.0018205084,
0.002829485,
-0.014082168,
0.011599048,
0.0055987327,
-0.009169472,
-0.003123979,
-0.010360834,
0.022943761,
0.00032084787,
-0.0012449065,
-0.0025400107,
-0.013432942,
-0.016531823,
-0.032340795,
-0.0354196,
0.029556489,
-0.041844923,
-0.0023258333,
0.0028847028,
0.008828127,
0.03338491,
-0.0003260768,
0.0091560865,
-0.0069875396,
0.040292136,
-0.039837006,
0.010621863,
0.013693972,
0.0041496884,
-0.009597828,
-0.0056890887,
-0.019008249,
-0.027334398,
0.015019194,
-0.010280518,
-0.042674858,
-0.025219396,
-0.0032042956,
0.01777673,
0.015715271,
-0.015541252,
0.020159453,
0.0054380996,
0.027762754,
0.008419852,
-0.011806533,
0.02202012,
-0.039944097,
0.0014331484,
0.0032628598,
-0.027414715,
-0.011036832,
-0.00021417746,
-0.020815372,
0.00030871673,
-0.0057760985,
-0.00791118,
-0.032046303,
-0.007978111,
-0.005923345,
0.0007538043,
-0.015527866,
-0.006458789,
-0.010488003,
-0.003922125,
0.012777024,
-0.011639207,
-0.0044709546,
-0.016223943,
-0.014229415,
0.027039904,
-0.023987876,
-0.0013578517,
-0.005090061,
-0.025072148,
-0.014724701,
-0.013600268,
-0.01883423,
0.029261995,
0.022354772,
-0.0012206442,
-0.028726552,
-0.006836946,
-0.06821552,
-0.00387862,
0.02674541,
-0.01784366,
0.009484045,
0.04160397,
-0.013787674,
0.018472806,
-0.015554638,
0.020253155,
-0.012388827,
0.0035238885,
0.017803501,
-0.0063851657,
0.04098821,
0.022046892,
-0.025246168,
-0.007087935,
0.04695841,
-0.018205084,
-0.0030587218,
0.033197507,
-0.007382429,
0.017281445,
-0.0076970025,
0.0032494736,
-0.002777614,
0.013667199,
-0.0016565288,
-0.019101953,
-0.0038752735,
0.0004772978,
-0.015875904,
0.0029984845,
0.0023408928,
-0.0030871674,
0.012663242,
0.021765785,
0.009584442,
-0.039917324,
0.009263176,
-0.023679996,
0.018807458,
0.030439971,
-0.016598754,
0.0031725036,
0.0035305815,
-0.0036175912,
-0.00085921976,
-0.008741118,
0.00534105,
-0.009363571,
-0.016090082,
0.0039422037,
-0.009189552,
-0.00953759,
-0.0008337025,
-0.028753323,
-0.00032649512,
0.0007353984,
-0.010160043,
-0.036758207,
0.007134787,
0.018472806,
-0.020052364,
0.0055284556,
-0.0026638322,
-0.022796514,
-0.009463967,
0.009771846,
0.004675092,
-0.0077036954,
-0.009577748,
-0.004825686,
-0.015434164,
0.004511113,
-0.0077371607,
-0.009550977,
-0.025272941,
-0.006338314,
0.19126047,
-0.028726552,
-0.017696412,
0.016933406,
0.0049495073,
-0.007924566,
-0.014523909,
-0.01303136,
0.0061107506,
-0.006606036,
0.025969017,
-0.0030035041,
-0.015808973,
-0.0036577494,
-0.0019376368,
0.009477353,
-0.027334398,
-0.00682356,
-0.020775214,
0.003296325,
0.01821847,
-0.0020447255,
-0.00082408125,
0.009905707,
0.04786866,
-0.008433238,
-0.00012789993,
0.011431722,
0.008172208,
-0.000069806374,
-0.043826062,
0.0110769905,
0.006810174,
-0.0033314636,
-0.0027240696,
0.0011269415,
-0.017629482,
-0.0022237643,
0.011719523,
0.009370264,
-0.017254671,
0.010360834,
-0.00040848495,
0.0019192308,
-0.007971417,
0.03780232,
0.01938306,
-0.02017284,
0.009986024,
-0.016893247,
-0.035874724,
-0.0041496884,
0.002022973,
0.016438121,
0.008312763,
-0.00883482,
0.013325854,
0.010842734,
-0.0036644426,
0.015246758,
-0.023639837,
-0.008386387,
-0.03226048,
0.03421485,
-0.0034469184,
0.02859269,
-0.031591177,
0.017094038,
0.024054807,
-0.027173765,
-0.00021710567,
0.010528161,
-0.011739602,
-0.0077438536,
-0.022863444,
-0.012797103,
0.012515996,
0.019891731,
0.023439046,
0.012034096,
0.02109648,
0.005307585,
-0.0152199855,
0.002151814,
-0.004621548,
-0.01927597,
0.033277825,
0.005133566,
-0.031617947,
0.01534046,
0.009022226,
-0.007884407,
-0.009798619,
-0.004410717,
-0.016090082,
0.01386799,
-0.00013971733,
-0.00036414352,
-0.0020882303,
-0.015942834,
-0.030975414,
0.06355716,
0.0048089535,
0.009872242,
-0.01333924,
0.022140594,
-0.0020597847,
0.006933995,
0.0006350027,
-0.009899015,
0.011987245,
-0.025165852,
0.006124137,
-0.0011327979,
-0.027374556,
0.017803501,
-0.01404201,
-0.01914211,
0.03900707,
-0.0073958156,
-0.0055853464,
-0.024309142,
-0.0028445444,
0.025540663,
-0.00040116443,
0.016665684,
-0.030948643,
-0.00605386,
-0.009611214,
-0.035901498,
0.013734129,
-0.002834505,
-0.008714345,
0.03972992,
0.0047721416,
-0.015661728,
-0.007389122,
-0.035901498,
-0.016438121,
0.009825391,
-0.00775724,
-0.017308217,
0.006395205,
0.0048993095,
-0.0031607908,
0.00027483318,
0.018031064,
0.02017284,
-0.016451506,
-0.006719818,
0.017723184,
-0.044495367,
-0.027280854,
-0.024724111,
0.00020999431,
-0.0028780096,
-0.00852694,
0.0009353531,
-0.020962618,
0.033197507,
-0.019101953,
0.013419556,
0.004052639,
-0.009176166,
-0.006512333,
-0.0072485683,
-0.16887893,
0.0040927976,
0.011344712,
-0.023345344,
0.017134197,
0.0028512375,
0.011639207,
-0.0001863595,
-0.012234887,
0.008721039,
0.036999155,
-0.012904192,
-0.028539147,
-0.014564067,
0.008024962,
0.008473395,
-0.023479205,
0.011980551,
0.014523909,
0.0065324125,
0.018780686,
-0.02612965,
0.016839704,
-0.013332547,
0.0040760646,
0.02496506,
-0.006733204,
-0.028405286,
-0.010976595,
-0.013948307,
-0.018191699,
0.004882577,
0.019597238,
-0.014831789,
0.021257114,
-0.010180122,
-0.009530897,
-0.0016523456,
0.0001670124,
0.032662064,
0.03547314,
0.007509597,
0.0057794447,
-0.008734425,
-0.00799819,
0.040265363,
0.011960473,
0.002041379,
0.025687909,
-0.004601469,
0.027267467,
-0.00090774434,
0.01575543,
0.023439046,
0.019918503,
-0.0050298236,
0.00006975408,
-0.00861395,
-0.007951338,
0.0058329892,
0.017268058,
-0.0029516332,
0.015768815,
-0.011451801,
-0.015005808,
-0.032421112,
-0.014202643,
0.025500504,
-0.0177098,
-0.0012198075,
-0.028753323,
-0.00039258896,
0.014791631,
-0.022943761,
0.0114852665,
0.027120221,
-0.00534105,
-0.002399457,
0.016866475,
-0.0057058213,
-0.020199612,
0.010755724,
-0.013479793,
-0.009363571,
-0.028110791,
-0.0018121421,
-0.010160043,
0.015715271,
-0.0090356115,
-0.012368748,
-0.018178312,
-0.03873935,
0.016505051,
-0.025286326,
0.017522393,
0.022515405,
-0.021792557,
-0.0028847028,
-0.019128725,
-0.018472806,
0.019717712,
-0.011873463,
0.000019059493,
0.0075765275,
0.008386387,
0.0010474616,
-0.0012474164,
0.00078601454,
0.016558595,
0.022287842,
-0.016103467,
0.013312467,
0.016665684,
0.023907559,
-0.0058664544,
0.015099511,
-0.003065415,
-0.0072351824,
0.006927302,
-0.019423218,
0.067358814,
0.0071414798,
-0.014778244,
0.014229415,
-0.0057058213,
-0.027682437,
-0.13825156,
-0.01698695,
0.014095554,
-0.006257998,
-0.018861003,
0.0035540073,
-0.0002382306,
0.022488633,
-0.027575348,
-0.0007111361,
-0.0268525,
-0.00049737695,
0.00082408125,
-0.024202053,
-0.013151835,
0.0030704348,
0.025808385,
0.005140259,
-0.009430502,
0.047172587,
0.0009822045,
-0.0021936458,
-0.01217465,
-0.0064052446,
0.0066528874,
-0.0018288747,
-0.04650328,
0.029369084,
0.0012967776,
0.018245243,
-0.0036577494,
-0.014671156,
0.030975414,
-0.0042802026,
-0.00852694,
0.010936436,
-0.010782496,
-0.0061944136,
0.03924802,
0.012797103,
-0.017455462,
0.021310657,
0.0016280833,
0.004537885,
0.02760212,
-0.019342901,
-0.024268983,
0.0131853,
0.030627377,
-0.021150025,
-0.007476132,
-0.019476762,
-0.03855194,
-0.014858562,
0.0042835493,
-0.0010073034,
0.000049779526,
0.021123253,
-0.013205379,
0.0024228825,
0.020641353,
-0.016049923,
-0.013693972,
0.0014741434,
0.04733322,
-0.016183784,
-0.016277486,
-0.013519952,
0.03437548,
-0.04599461,
0.013499873,
-0.005036517,
-0.02349259,
-0.007810784,
-0.018673597,
-0.002573476,
-0.01094313,
-0.0074359737,
0.0038284222,
-0.01821847,
-0.017749958,
-0.002956653,
-0.0028244653,
-0.0047587557,
0.028298197,
-0.0023777045,
0.0072351824,
-0.0010909664,
0.008941909,
-0.0026906044,
0.0029298807,
0.040185045,
0.0025784958,
-0.0011453475,
-0.021069707,
0.022850057,
-0.0117730675,
-0.01527353,
0.018780686,
0.0401315,
-0.016049923,
-0.020427175,
-0.055739682,
0.012321897,
-0.015045967,
0.0135266455,
0.019503536,
-0.007944645,
0.005414674,
-0.024322528,
0.00534105,
0.015956221,
0.00364771,
-0.010662022,
-0.014885333,
0.017642869,
-0.030386427,
-0.017455462,
0.011418336,
-0.0130581325,
0.010501388,
0.031430542,
-0.0071147075,
-0.039676376,
0.0053176247,
0.025192624,
-0.0010792536,
0.006087325,
-0.017201127,
0.027575348,
-0.0006329111,
0.015407391,
0.0258887,
-0.02331857,
-0.018071223,
0.0019610624,
-0.016612139,
0.0065257195,
-0.012897499,
0.039140932,
0.015286916,
0.025433574,
-0.016277486,
-0.029984845,
-0.001280045,
-0.015327075,
-0.020681512,
-0.0013235498,
-0.040265363,
0.010641943,
0.0076099928,
0.00014180891,
0.03408099,
0.016571982,
-0.005076675,
-0.023198096,
-0.012529382,
0.01410894,
-0.00041141314,
-0.012723479,
-0.029208452,
-0.023117779,
0.025005218,
-0.0038049964,
0.02410835,
-0.0016464893,
0.0037648382,
-0.02452332,
-0.03873935,
0.003072108,
0.0030938603,
-0.0033682752,
-0.018138153,
0.023920946,
0.003047009,
0.0044475286,
0.0098521635,
0.001805449,
-0.014296345,
-0.00007195024,
-0.0018656865,
0.008239139,
0.023157937,
0.0013360992,
-0.015313689,
-0.012964429,
0.024884744,
-0.006606036,
0.01588929,
0.005933385,
-0.002836178,
-0.0026855846,
0.01226166,
0.016223943,
0.013546725,
0.0062780767,
0.010501388,
0.027307626,
0.012977815,
0.00013595249,
0.018727142,
0.031377,
0.003167484,
-0.019530308,
0.004665053,
-0.0022070317,
-0.011177386,
0.015246758,
-0.03533928,
-0.03702593,
-0.015139669,
-0.0030570487,
0.004755409,
-0.00060362904,
0.015394005,
-0.0061977603,
-0.028726552,
-0.0006266364,
0.0013043073,
0.020735055,
-0.017937362,
0.030573832,
-0.0031540978,
0.008473395,
0.0017318255,
0.00005919162,
0.016478278,
-0.0021936458,
0.0243493,
-0.028485602,
0.020253155,
-0.009457273,
0.016679069,
-0.022461861,
-0.028405286,
0.0007492028,
-0.007047777,
-0.01687986,
0.009069077,
0.038444854,
-0.017495621,
0.08020946,
0.018981477,
-0.013841218,
-0.0090958495,
-0.01465777,
0.02208705,
0.017883819,
0.024483161,
-0.008071813,
-0.019958662,
0.021739012,
-0.00013438381,
0.031055732,
-0.03533928,
-0.025433574,
0.027441487,
-0.0056522773,
-0.011565583,
0.022461861,
-0.020614581,
-0.003667789,
-0.0050699823,
-0.0021986654,
0.022167368,
-0.032099847,
-0.012817183,
0.01380106,
0.008285991,
-0.0037815708,
-0.03841808,
0.012007324,
-0.011920314,
-0.05250025,
-0.010059647,
0.012924271,
-0.021551607,
-0.01637119,
-0.027575348,
-0.0019342902,
0.0045311917,
0.0030737813,
0.012690014,
-0.014550681,
-0.028512374,
-0.020801986,
-0.0119337,
-0.00883482,
-0.022609109,
0.011813225
] |
Insulin-regulated aminopeptidase (IRAP or oxytocinase) is a membrane-bound zinc-metallopeptidase that cleaves neuroactive peptides in the brain and produces memory enhancing effects when inhibited. We have determined the crystal structure of human IRAP revealing a closed, four domain arrangement with a large, mostly buried cavity abutting the active site. The structure reveals that the GAMEN exopeptidase loop adopts a very different conformation from other aminopeptidases, thus explaining IRAP's unique specificity for cyclic peptides such as oxytocin and vasopressin. Computational docking of | [
-0.040617928,
-0.0077996226,
0.014714471,
-0.025481489,
-0.010556034,
0.009337768,
-0.010358661,
-0.005662553,
-0.017600195,
-0.018321626,
0.02191517,
-0.010229348,
-0.007881294,
-0.004862854,
-0.014959485,
0.0063295364,
0.018811654,
0.022432422,
-0.011168569,
0.0028516944,
-0.023004122,
0.011297883,
0.010576451,
-0.025726503,
0.0027087694,
-0.0036956326,
-0.010399497,
-0.040944614,
0.0051725246,
-0.039311185,
-0.011161763,
-0.009793767,
-0.01084869,
-0.0011697733,
-0.011563315,
-0.0054821954,
0.0040325276,
-0.010004751,
0.022976898,
0.00049768534,
0.02554955,
-0.0040529454,
0.0018563238,
0.019900607,
0.014891426,
-0.010474362,
0.0031800817,
-0.0011314898,
-0.007132639,
0.020867053,
0.015708141,
0.01138636,
-0.00982099,
-0.012774775,
0.012543372,
-0.0030150374,
-0.0074048773,
0.01942419,
0.0138637265,
-0.020104786,
-0.0010821465,
0.004624645,
-0.035880987,
0.03234189,
0.027223814,
0.026747396,
-0.016007602,
0.013924981,
0.011556509,
0.014278891,
0.048567284,
0.020458696,
-0.019750876,
0.0026100832,
0.027455216,
-0.02356221,
-0.03454702,
-0.020145621,
0.019573921,
0.030082313,
0.028312765,
-0.004110796,
-0.01599399,
0.016592914,
0.011243435,
-0.0035765285,
0.0039508557,
0.008868157,
-0.011679016,
0.0014922053,
0.006292104,
0.027251037,
0.011597345,
0.029537838,
-0.022976898,
0.019097505,
-0.026611278,
0.018212732,
-0.002986112,
-0.022459647,
-0.0028840227,
0.035009824,
-0.0010055796,
-0.013829697,
0.0043081683,
-0.010072811,
-0.008310069,
-0.0130334,
0.037024386,
0.023262748,
0.0009026396,
0.04154354,
0.001902264,
-0.031797413,
0.0060198656,
0.020445084,
0.02776829,
-0.010787436,
-0.018607477,
-0.019505862,
-0.00029286867,
0.019791713,
0.009017888,
-0.0063805813,
0.031742968,
0.028938914,
-0.005274614,
-0.010120452,
0.006843386,
-0.010909943,
0.0112366285,
0.012107791,
0.015612857,
-0.0014454144,
-0.024038628,
0.025481489,
0.0014658322,
-0.018267179,
-0.014700859,
-0.01641596,
0.004376228,
0.0298373,
-0.027849961,
0.013836503,
-0.009575976,
0.030300105,
0.0145647405,
0.0077723986,
0.015408678,
0.037269402,
0.005060226,
-0.036806595,
-0.021166515,
-0.009296932,
0.019927831,
0.0140611,
0.0014258472,
0.029728403,
-0.019805323,
-0.011495255,
0.0059211794,
-0.0098958565,
-0.0073368177,
-0.0079697715,
0.02627098,
0.016538467,
0.005206554,
0.00264071,
0.014101936,
-0.01002517,
0.012924505,
0.006812759,
-0.018103836,
0.0048798686,
-0.021887945,
0.012012508,
0.018811654,
0.010113646,
-0.00953514,
-0.0020009503,
-0.022636602,
-0.0066766404,
0.0076907272,
-0.0013824593,
-0.0076022497,
0.0028244706,
0.024392536,
-0.026039578,
0.006720879,
-0.023643881,
0.0005100211,
-0.003947453,
-0.027577722,
-0.04124408,
-0.63377035,
-0.028258318,
0.022582153,
-0.008602725,
-0.0028380826,
0.043367535,
0.0033910663,
-0.008487023,
0.014836978,
0.026543219,
-0.004791391,
0.038576145,
0.0032396337,
-0.028258318,
-0.024378926,
-0.036806595,
-0.0008252218,
-0.010229348,
0.010120452,
-0.0027172768,
-0.008167144,
0.02220102,
-0.00011931687,
0.010549228,
0.011440808,
0.006955684,
0.032804694,
-0.017436853,
-0.008725232,
0.014360562,
0.006591566,
0.012257522,
-0.019723652,
0.0073095937,
0.0596746,
-0.015395067,
-0.005536643,
0.023861673,
-0.0012437879,
0.051425785,
-0.005832702,
-0.0015874886,
0.0009894155,
-0.0010804451,
-0.003637782,
0.0061151492,
0.0133396685,
0.012073761,
0.010079617,
-0.024705611,
-0.009997945,
0.0060538957,
-0.02970118,
0.014864202,
0.015857872,
0.020104786,
0.026094025,
-0.0134009225,
0.03419311,
0.022473257,
0.0051418976,
0.011488449,
-0.029211152,
-0.02612125,
-0.015000321,
0.0032770666,
0.00054915535,
0.0042877505,
-0.009827796,
0.006720879,
0.007200699,
0.012380029,
-0.0029010377,
-0.011828747,
0.009256097,
0.03814056,
-0.02020007,
0.023004122,
-0.0152044995,
0.0042911535,
0.0072619524,
0.009119977,
-0.028830018,
0.006877416,
0.005689777,
0.012271134,
-0.0052405843,
0.011563315,
0.013332862,
-0.00055638666,
0.025290923,
0.0009094455,
-0.013448563,
-0.031661294,
-0.04603547,
0.019791713,
-0.012502536,
0.01606205,
0.009174425,
0.0004330288,
0.00022587257,
0.0016529959,
-0.006370372,
-0.002411009,
0.051153544,
0.0043081683,
-0.03277747,
0.0078064287,
0.049111757,
-0.0015568618,
-0.017831597,
-0.013312445,
0.003501663,
-0.02184711,
-0.0025828592,
-0.012339193,
0.017518524,
0.0044374815,
0.00095283345,
-0.028721124,
0.009004276,
-0.018607477,
0.0055332403,
0.00629891,
0.018063,
0.0023854866,
0.0005980731,
-0.010474362,
-0.011481644,
-0.010930361,
0.002856799,
-0.009548753,
0.0066698343,
-0.021234574,
0.019437803,
0.044674277,
0.009746125,
-0.004532765,
-0.010685347,
-0.015013933,
-0.01342134,
-0.0051895394,
-0.0017695478,
-0.009623618,
-0.0070373556,
-0.017926881,
0.0026985605,
0.005788463,
0.0051487037,
-0.009174425,
0.0032362307,
0.01081466,
0.0006278492,
0.02991897,
0.030245656,
-0.02026813,
-0.01641596,
-0.015490349,
-0.024406148,
0.0093105445,
0.0026015756,
0.026039578,
-0.016225392,
-0.0064758644,
-0.0054855985,
-0.03234189,
0.020608427,
0.02569928,
-0.014115547,
-0.04227858,
-0.0017253092,
-0.007010132,
-0.01927446,
0.0011399972,
-0.00046833468,
0.021207351,
0.008698008,
-0.0010787436,
-0.010079617,
-0.01056284,
-0.010154482,
0.0056217173,
-0.011039256,
0.0020775173,
0.019573921,
0.022364363,
0.019233624,
0.024828117,
0.020186458,
0.018226342,
-0.029810075,
0.03228744,
0.0028108587,
0.040318467,
-0.0017227569,
-0.025957907,
0.02363027,
0.013373698,
-0.002128562,
0.03027288,
0.03762331,
-0.027264649,
0.0047437493,
-0.014836978,
0.0052984348,
-0.0163479,
0.009126783,
-0.027795514,
0.017532136,
-0.021792663,
-0.012482119,
0.0024008001,
-0.0017916672,
0.008371322,
0.000018277708,
-0.008003801,
-0.0023072183,
0.0011042659,
-0.021329857,
-0.012359612,
0.015694529,
0.006839983,
0.0015891901,
0.0037773042,
-0.018185508,
0.0028108587,
0.030354552,
0.013414534,
-0.01777715,
-0.05161635,
0.007459325,
0.014687248,
0.01804939,
0.022500481,
0.009412633,
0.0073300116,
0.0049717487,
-0.0060947314,
0.043231416,
0.0074797426,
0.0024416358,
0.0025896654,
0.0076771155,
0.0140611,
-0.0031562608,
-0.0090315,
0.018335238,
0.025821786,
-0.011216211,
0.0016734138,
-0.0128700575,
0.016334288,
-0.026638502,
0.015789812,
-0.03503705,
0.024882566,
0.0117743,
0.004093781,
0.042469148,
0.024691999,
-0.000082469014,
0.010181706,
0.0051487037,
-0.009337768,
0.00028542467,
0.0022425617,
0.0045940187,
-0.023303585,
-0.019410579,
-0.0052984348,
0.007731563,
-0.0012710118,
0.019982278,
0.0021608903,
0.004822018,
0.02477367,
-0.010372273,
0.0032073054,
0.018661924,
-0.010018364,
-0.017559359,
-0.052215274,
0.026747396,
0.012774775,
-0.0050942563,
-0.0073844595,
-0.029292824,
-0.01991422,
-0.00056659564,
0.016307063,
0.0011442509,
0.01913834,
0.0149730975,
0.03005509,
-0.016647361,
-0.026379876,
0.028285543,
-0.023426091,
0.0031069177,
-0.005717001,
-0.009963916,
-0.0011978478,
-0.0140611,
0.0023004122,
0.04312252,
0.013346475,
0.00232083,
-0.027509663,
-0.013264803,
-0.015177276,
0.007159863,
0.024378926,
0.009344574,
-0.0094262455,
0.0044544963,
0.006989714,
-0.013448563,
-0.0025199042,
-0.0034165885,
0.0025386205,
-0.027482439,
-0.028802795,
-0.003923632,
0.001050669,
0.021057619,
0.019328907,
0.011175375,
0.010052393,
0.013679966,
-0.010624093,
-0.025032297,
-0.00807186,
-0.004212885,
0.002819366,
-0.011393166,
-0.0069658933,
0.0073164,
-0.0073844595,
0.0030473657,
0.009997945,
-0.009793767,
-0.03304971,
-0.0026781426,
0.0015551604,
0.04399368,
0.009732514,
-0.004651869,
0.021465978,
0.026148472,
0.0020536964,
0.014455845,
0.036126,
0.006717476,
-0.03348529,
0.016239004,
0.0076226676,
-0.0022238453,
0.0026832472,
-0.013496205,
-0.043803114,
0.012277939,
-0.004352407,
0.032015204,
0.013298833,
0.0066562225,
0.034737587,
0.0056489413,
0.0020894278,
-0.0026747396,
-0.029810075,
0.011781105,
0.010181706,
-0.0077996226,
-0.014360562,
0.013666354,
0.0023769792,
-0.009480693,
-0.025386207,
-0.0072619524,
0.0006048791,
0.013639131,
-0.00817395,
-0.00496154,
-0.029646732,
-0.00442387,
-0.020445084,
-0.0037534833,
-0.019220011,
0.0005916926,
-0.013795667,
-0.010202124,
-0.016660973,
-0.005992642,
-0.008452994,
0.026366264,
-0.044674277,
-0.025399817,
0.01498671,
-0.002550531,
0.008024219,
-0.0070781913,
-0.009330962,
0.012264328,
0.012420865,
-0.00080650544,
-0.015585633,
0.014578352,
-0.022595765,
0.004719929,
0.006152582,
-0.000438984,
-0.026665725,
-0.024855342,
-0.025685668,
0.025086744,
-0.0072211167,
0.04334031,
-0.0012642058,
0.0005653195,
0.017382406,
0.017613808,
0.018171895,
0.00953514,
-0.011801523,
0.0028295752,
-0.02013201,
-0.019791713,
-0.01742324,
-0.0021132485,
0.015966767,
-0.0035663196,
0.027523275,
-0.0011399972,
-0.02761856,
0.00040048783,
0.0044306754,
-0.014360562,
0.0016470407,
0.027509663,
0.012305164,
-0.004954734,
0.023453316,
-0.027278261,
-0.028285543,
-0.017940493,
-0.021928782,
0.009780155,
0.02642071,
-0.020281741,
0.020812605,
-0.001499862,
-0.008316875,
0.0044510933,
0.008214786,
-0.012720327,
0.030354552,
0.014823366,
-0.018906938,
-0.010487974,
-0.021302635,
-0.036806595,
0.005278017,
0.0023820836,
-0.024528656,
-0.015354231,
-0.014455845,
-0.0079085175,
0.0031596639,
0.005104465,
-0.031960756,
0.010664929,
0.013183132,
-0.02891169,
-0.006880819,
-0.011297883,
-0.003525484,
-0.027251037,
-0.0011178778,
-0.02961951,
-0.027673006,
-0.012162238,
-0.0084598,
0.024256418,
0.027019635,
0.037922774,
-0.008616337,
-0.009072335,
0.030327328,
0.016388735,
0.007003326,
0.024025016,
-0.007738369,
-0.02956506,
0.020472307,
0.01135233,
-0.017396016,
0.022160184,
-0.039964557,
0.010134065,
-0.0073164,
-0.014578352,
-0.02877557,
0.0063601634,
-0.028830018,
-0.01641596,
-0.004985361,
-0.0076498915,
-0.011869582,
-0.03084458,
-0.004134617,
0.01841691,
-0.0114135835,
0.029592285,
-0.032586906,
0.029238375,
-0.023439704,
0.018580252,
0.025508713,
0.014864202,
-0.008112696,
-0.006428223,
0.004495332,
0.012100985,
0.012046537,
-0.011291076,
0.025154803,
0.006411208,
-0.004794794,
-0.0053630914,
0.023371644,
-0.0062852977,
0.021234574,
0.010542422,
-0.016484018,
0.0054821954,
-0.0015670707,
-0.01562647,
-0.064357094,
0.00047811822,
0.013693579,
0.000096665804,
0.038576145,
-0.00807186,
-0.0016546973,
0.012570595,
0.0017219062,
0.016211782,
-0.009596394,
0.02833999,
0.025086744,
0.019315295,
-0.000034295623,
-0.008065055,
0.0030133359,
0.00042303253,
0.017872434,
0.034220334,
0.023303585,
-0.03525484,
-0.011502061,
0.00227489,
-0.028966138,
-0.03626212,
0.017314345,
-0.016538467,
0.011141346,
-0.02684268,
-0.0039508557,
0.0059075677,
0.036153223,
-0.024760058,
0.010379079,
-0.0066460134,
0.0024348297,
-0.033866424,
0.014047488,
0.010637705,
0.017055718,
0.011679016,
-0.013407728,
-0.009147202,
-0.0281222,
-0.015517574,
-0.012944923,
0.013332862,
0.01316952,
-0.0045599886,
0.019247236,
0.0010523705,
-0.0002896784,
0.00807186,
-0.0084598,
0.00476757,
0.036126,
0.004954734,
-0.013257997,
-0.00083415466,
-0.010508392,
-0.0016963838,
-0.008507442,
0.006081119,
-0.0020145623,
-0.016974047,
-0.0022868004,
0.009487499,
0.0058258963,
-0.02127541,
-0.0017057421,
-0.021792663,
0.0163479,
-0.019655593,
-0.008316875,
0.02191517,
-0.051589128,
-0.031116819,
-0.019233624,
0.0022595765,
0.005352882,
0.024351701,
-0.00064401334,
0.0034574242,
0.022908838,
-0.045109857,
0.015054769,
-0.006469059,
0.003501663,
-0.008568695,
0.0005249092,
-0.0050193905,
-0.007438907,
0.028367214,
-0.036588807,
-0.018716373,
0.010909943,
-0.016375124,
0.02842166,
0.009997945,
0.0022561736,
0.008970247,
-0.019941444,
0.00054872996,
0.011890001,
-0.004240109,
0.007432101,
-0.03005509,
0.01342134,
0.019233624,
-0.03318583,
-0.029156704,
-0.014537516,
-0.003198798,
0.021574872,
-0.013414534,
-0.018103836,
-0.010358661,
-0.01819912,
-0.013346475,
-0.0146328,
0.015068381,
0.016946824,
-0.032614127,
0.014469457,
0.027496051,
-0.024828117,
-0.03125294,
0.013366892,
-0.0052984348,
-0.010556034,
0.001895458,
0.0068978337,
0.029946195,
-0.019927831,
-0.021983229,
-0.0066221924,
-0.022037677,
0.03419311,
0.010515198,
-0.036670476,
-0.03424756,
-0.004502138,
-0.044919293,
-0.0007448265,
-0.036724925,
0.026025966,
0.0076975334,
-0.00043600638,
0.0052950317,
0.012420865,
0.007609056,
0.004937719,
-0.0064860736,
-0.022405198,
0.006155985,
-0.018757207,
0.032178547,
-0.012277939,
-0.016484018,
-0.025454266,
0.03228744,
0.0034659316,
0.0014990112,
0.028231094,
-0.01641596,
0.004502138,
-0.0075205783,
-0.0011263853,
0.008643561,
0.007683921,
0.02405224,
-0.02098956,
-0.010685347,
0.00820798,
-0.0041482286,
-0.004542974,
0.0012174149,
-0.0117743,
0.017804373,
-0.0019499057,
-0.0045872126,
-0.00451575,
0.010072811,
-0.007881294,
0.020172846,
0.018634701,
-0.0105356155,
-0.000028898716,
-0.005553658,
-0.012863251,
-0.018525805,
0.0012395342,
-0.030735685,
0.0022765915,
0.014442233,
0.00063295366,
-0.0063601634,
-0.0031817832,
0.020880666,
-0.03198798,
0.01310146,
0.013060625,
-0.010093229,
-0.01727351,
-0.0011289375,
0.019165564,
0.0046824957,
-0.016089274,
0.0027666201,
0.0072415345,
-0.020540368,
0.005591091,
-0.002285099,
-0.0038759904,
-0.022323526,
0.0010685347,
-0.033920873,
-0.0018308015,
-0.02070371,
-0.022827167,
-0.011849165,
0.027754677,
0.18871547,
-0.016742645,
0.0061866115,
-0.0019277863,
-0.01641596,
0.0005989239,
-0.0021830096,
-0.0098346025,
-0.0076566976,
0.0014011756,
0.016320676,
0.015109217,
-0.015721751,
-0.0034370064,
-0.0009724006,
-0.000026479413,
-0.023466928,
0.00066655804,
-0.015054769,
0.0024824715,
0.0031069177,
0.01907028,
0.018974997,
0.010113646,
0.035309285,
-0.005261002,
-0.03149795,
0.0013603399,
0.0021200546,
0.019886995,
-0.024637552,
0.0020809202,
0.0013373698,
0.0066358047,
0.024310865,
0.00083117705,
-0.011610956,
0.0045770034,
0.010991614,
0.001665757,
-0.013788861,
0.038113337,
-0.0020656069,
-0.0023327405,
-0.02948339,
0.0004525959,
0.0074865487,
-0.036724925,
0.013870533,
0.018171895,
-0.04775057,
0.010862301,
0.023711942,
0.020867053,
0.018376075,
-0.02005034,
-0.009160813,
0.015953155,
0.0025147998,
0.026597666,
-0.014959485,
0.0049070925,
-0.024596715,
0.023426091,
-0.020472307,
0.03462869,
-0.012536566,
-0.015395067,
0.017600195,
-0.0138637265,
0.008065055,
0.0017142495,
-0.025073132,
-0.011610956,
-0.020322576,
-0.005846314,
0.029673956,
0.043585327,
0.00585312,
0.008874963,
0.012836028,
0.000019846266,
-0.023167465,
0.011563315,
-0.024310865,
-0.03255968,
0.019927831,
0.011855971,
-0.043966457,
-0.008766068,
0.0026934561,
-0.03427478,
-0.01056284,
-0.009725708,
0.0023225315,
-0.018171895,
-0.009827796,
-0.001762742,
-0.017300734,
-0.014115547,
-0.0030048285,
0.05755114,
0.015395067,
0.027645782,
-0.020744545,
-0.00820798,
-0.013782055,
0.017600195,
0.0084598,
-0.018906938,
0.004685899,
-0.017981328,
0.0039542587,
-0.018634701,
-0.018185508,
0.009276514,
0.009548753,
-0.020553978,
0.01599399,
-0.0047063166,
-0.024583103,
-0.012652268,
-0.0057782545,
0.0021676961,
0.015708141,
-0.008466606,
-0.039147843,
0.00528142,
0.009154007,
-0.020649262,
-0.003933841,
0.010678541,
0.011440808,
0.0027955454,
0.00756822,
0.0026883516,
0.012427671,
-0.019220011,
0.03628934,
0.027019635,
-0.005278017,
0.010147677,
0.02070371,
0.003282171,
0.006254671,
-0.005077241,
0.022214632,
0.02512758,
0.004522556,
-0.0043013627,
-0.0050330027,
-0.030000642,
0.018171895,
0.0066596256,
0.027904408,
-0.025045909,
-0.023616659,
-0.02241881,
0.0052405843,
-0.0174913,
-0.019764489,
0.0050432114,
0.017110167,
-0.0013952204,
-0.020472307,
0.0026594263,
-0.17314345,
0.012141821,
0.022813555,
-0.02113929,
0.030817356,
0.007540996,
-0.012039731,
-0.006421417,
0.017464077,
0.009555559,
0.017872434,
-0.013074236,
-0.014360562,
-0.011229823,
0.003414887,
0.0041550347,
-0.010794242,
0.0039984975,
0.031525176,
-0.0025284116,
0.011597345,
-0.023181077,
0.035499852,
-0.014115547,
-0.0003432753,
0.017559359,
-0.0073980712,
-0.008126308,
-0.001592593,
-0.005710195,
-0.0016989361,
0.015680917,
0.05354924,
0.0022799943,
0.03019121,
-0.0074525187,
-0.0061151492,
-0.0035322898,
-0.01742324,
0.030408999,
0.035527077,
0.025331758,
-0.015694529,
0.0029350673,
-0.007935742,
0.029537838,
0.002397397,
-0.0069420724,
0.012733939,
0.007758787,
0.019165564,
-0.017790763,
-0.004352407,
0.032886367,
0.021193739,
0.006693655,
-0.00021523828,
0.009473887,
-0.011604151,
-0.0051963455,
-0.01799494,
0.006697058,
0.050663516,
-0.0004330288,
0.0054447628,
-0.016837928,
-0.0026475159,
0.005720404,
-0.017954106,
0.017572971,
-0.022500481,
-0.016579302,
0.010052393,
-0.030463448,
0.011842359,
0.023044959,
0.0021353678,
0.00035433494,
0.02642071,
0.0070645795,
-0.014864202,
0.005536643,
-0.03454702,
-0.011257047,
-0.0023871881,
-0.008983859,
0.00011134114,
0.014510293,
-0.0027121725,
-0.008650367,
0.0169196,
-0.02349415,
-0.0064622527,
-0.0041516316,
0.030354552,
0.014523905,
-0.0033247082,
0.006009657,
-0.00047301376,
-0.032586906,
0.027074082,
0.015313395,
-0.0011451016,
0.0014428621,
0.019859772,
0.009650842,
-0.023643881,
-0.015694529,
0.024242805,
0.002184711,
-0.018934162,
-0.023807224,
0.0075750262,
0.014510293,
-0.035418183,
0.02248687,
-0.010624093,
-0.024746446,
0.03128016,
-0.015041157,
0.059075676,
0.008078666,
0.011406777,
0.013019789,
-0.040590707,
-0.036861043,
-0.12424948,
-0.044592608,
0.019356132,
0.014945874,
-0.029592285,
0.0018597267,
0.013952204,
0.03705161,
-0.014836978,
0.025794564,
-0.0073980712,
-0.00071419973,
0.0054753893,
-0.001137445,
0.009228873,
0.015408678,
-0.01799494,
-0.025903458,
-0.033076935,
0.04505541,
-0.011127734,
-0.0070441617,
0.026284592,
0.00982099,
0.015027545,
-0.013019789,
-0.01338731,
0.017368793,
0.0021523826,
0.003358738,
0.016034827,
-0.0086707845,
0.0366977,
0.009909468,
-0.027836349,
-0.011379554,
-0.013326056,
-0.015327007,
0.0315524,
-0.01491865,
-0.0034114842,
-0.018103836,
0.013605101,
0.010678541,
-0.006152582,
-0.017586583,
-0.0053562853,
-0.0135166235,
0.013598295,
-0.017654642,
-0.028312765,
-0.01167221,
-0.021234574,
-0.024882566,
0.038875606,
-0.021003172,
0.024964238,
0.027836349,
-0.006574551,
-0.024596715,
0.015258947,
-0.011522479,
-0.0074525187,
-0.018838879,
0.02162932,
-0.0054141358,
-0.014728083,
-0.023984179,
0.016960436,
-0.004525959,
0.0029316645,
0.0033281113,
-0.007704339,
-0.012727133,
-0.020077562,
-0.0053392705,
-0.014101936,
-0.008003801,
-0.007159863,
-0.005523031,
-0.018838879,
-0.030762909,
-0.0029844106,
-0.0061866115,
-0.019750876,
0.0048526446,
0.0015602648,
0.0026951574,
0.0006282746,
-0.0060675074,
-0.017872434,
0.027182978,
0.0018018761,
-0.024365313,
-0.006135567,
-0.010807854,
-0.0044476907,
-0.02077177,
0.0029912165,
0.016892375,
-0.038058892,
-0.010256572,
-0.0562444,
0.007996995,
-0.0051623154,
0.0075273844,
0.03283192,
-0.0026730383,
0.005812284,
0.009460275,
0.011644986,
-0.004794794,
-0.03334917,
0.022241855,
0.0024229195,
-0.0035765285,
-0.032886367,
-0.0075546084,
0.04562711,
-0.0062887007,
0.00953514,
0.014374173,
0.012699909,
0.014551128,
-0.018825267,
0.0061832084,
-0.00792213,
-0.0037602892,
-0.008167144,
0.013965816,
-0.008541471,
0.006404402,
-0.01877082,
-0.039365634,
-0.019519474,
0.025603997,
-0.016933212,
-0.012441283,
-0.027332708,
0.023711942,
0.023671106,
0.018621089,
-0.018621089,
-0.040917393,
0.0066255955,
-0.0064826705,
0.027523275,
-0.012767969,
-0.026801845,
-0.0054685837,
-0.017300734,
-0.021792663,
0.036806595,
0.017940493,
-0.004212885,
-0.019206401,
-0.012836028,
0.006258074,
0.007996995,
-0.016974047,
-0.01485059,
0.0035561107,
0.0338392,
-0.010474362,
0.013509817,
-0.011849165,
0.015408678,
0.011161763,
-0.036942713,
0.0030456642,
0.021901557,
0.0036752147,
-0.0214932,
-0.010453944,
0.0076771155,
0.013509817,
0.008990664,
-0.0007818339,
-0.018729983,
0.0031681713,
-0.0077451747,
0.025086744,
0.013292027,
-0.019818936,
-0.010195318,
0.014891426,
0.018580252,
-0.0073844595,
-0.006448641,
0.008282845,
-0.013965816,
0.009528334,
0.016865153,
0.013822891,
-0.00032392083,
-0.0012735641,
-0.0073844595,
0.016456796,
-0.010807854,
-0.027604947,
0.019968668,
0.01913834,
0.018430522,
-0.0025386205,
0.004699511,
-0.028258318,
-0.014169995,
0.0037262593,
-0.034220334,
-0.03762331,
-0.008568695,
0.016592914,
0.02376639,
-0.0057544336,
0.0067787296,
0.0067923414,
-0.009732514,
0.003072888,
0.00010761914,
-0.005226972,
-0.012890476,
0.017409628,
0.00935138,
-0.010617287,
0.009290126,
-0.012434477,
0.009038306,
0.017014883,
0.01804939,
-0.031824637,
0.024242805,
-0.011781105,
0.018294403,
-0.014741695,
-0.024705611,
-0.02098956,
0.0016683093,
0.008663978,
-0.0028125602,
0.022799945,
0.0006903789,
0.08237926,
0.005158913,
-0.019015834,
0.0053392705,
-0.0023327405,
0.02514119,
-0.019737264,
0.015544797,
-0.019818936,
-0.014319726,
0.012801998,
-0.011808329,
0.042850282,
-0.027931632,
-0.018525805,
0.0051963455,
-0.014428621,
0.019737264,
0.0018035776,
-0.039882887,
-0.0038657815,
-0.03299526,
-0.006128761,
0.014700859,
-0.034955375,
0.02877557,
0.032096878,
-0.005529837,
0.017681867,
-0.032586906,
-0.0058769407,
-0.011372748,
-0.019315295,
-0.010991614,
0.01627984,
-0.01513644,
-0.017586583,
-0.010351855,
0.01676987,
0.01784521,
-0.019043058,
0.008956634,
-0.020336188,
-0.009807379,
0.021193739,
0.0010047288,
-0.01399304,
-0.0020536964,
-0.021670155
] |
Increases in the intracellular levels of reactive oxygen species (ROS), frequently referred to as oxidative stress, represents a potentially toxic insult which if not counteracted will lead to membrane dysfunction, DNA damage and inactivation of proteins. Chronic oxidative stress has numerous pathological consequences including cancer, arthritis and neurodegenerative disease. Glutathione-associated metabolism is a major mechanism for cellular protection against agents which generate oxidative stress. It is becoming increasingly apparent that the glutathione tripeptide is central to a complex multifaceted detoxification system, where there is substantial inter-dependence between separate component members. Glutathione participates in detoxification at | [
-0.018995391,
-0.012628661,
-0.011691991,
-0.036654554,
-0.013440877,
0.02371149,
-0.008299021,
0.011456186,
-0.013185422,
-0.014764004,
0.013964888,
0.008600327,
-0.007801211,
0.014135191,
-0.0038383792,
0.0009162001,
0.044226512,
0.026488746,
0.005243383,
-0.0015294565,
-0.038934004,
0.0004470467,
-0.014750904,
-0.01654564,
0.019715907,
0.017148253,
0.0066876877,
-0.043335695,
-0.014357896,
-0.020266118,
0.011397235,
-0.01019201,
-0.022060854,
0.0076309075,
0.009825203,
0.0061538517,
0.016794546,
-0.016231235,
-0.016676644,
-0.01890369,
0.011207281,
0.004477017,
-0.0010750409,
0.011560989,
0.0042968886,
0.0037237518,
-0.016663544,
-0.018025972,
-0.00072952127,
0.022466963,
0.027877374,
0.028820595,
-0.014816405,
-0.034191705,
0.0061276513,
-0.0052597583,
-0.019152595,
0.007964964,
-0.00629468,
-0.023174377,
0.0063143303,
-0.0051156553,
-0.03489912,
0.02086873,
0.009844853,
0.017226854,
0.022204958,
0.024209298,
-0.014580601,
0.009268441,
0.026383944,
0.03303888,
-0.0038187287,
-0.00062349095,
0.006402757,
-0.020554323,
-0.037152365,
-0.010408165,
0.015798926,
0.009746601,
0.02568963,
-0.010486766,
0.003255417,
0.02140584,
0.004411516,
-0.008082867,
-0.019807609,
0.02711756,
0.0028689592,
-0.013991089,
-0.016860047,
0.0042248373,
0.01114833,
0.0040381583,
-0.014803305,
-0.0022892721,
0.0013002018,
0.03592094,
-0.024117596,
-0.016768346,
-0.011737842,
-0.011770593,
-0.014698503,
-0.025008416,
-0.045824744,
-0.008095967,
0.014501999,
0.021471342,
-0.005243383,
-0.011934346,
-0.0024890513,
0.03256727,
-0.010401614,
-0.03830519,
0.009628698,
0.009327392,
0.034715716,
0.032750674,
-0.014253094,
-0.03256727,
0.013676682,
0.0060556,
0.029921016,
-0.0051091053,
0.024654709,
-0.0069562434,
-0.024353402,
0.0019552154,
-0.007480254,
0.0034257206,
-0.010512967,
0.013991089,
0.0071134465,
-0.011796793,
-0.0194277,
0.035632733,
-0.035580333,
-0.014305495,
-0.014488898,
-0.028715791,
0.028506188,
0.022100156,
-0.018301077,
0.009504246,
0.020999733,
0.024523705,
0.036785558,
0.009576297,
-0.008973685,
0.006111276,
0.0032996305,
-0.002960661,
0.018746486,
-0.017305456,
0.00922914,
0.025034616,
-0.017226854,
0.025755132,
-0.027955975,
-0.028741993,
0.026934154,
-0.02519182,
0.0036254998,
0.0007737347,
-0.004323089,
0.022480063,
-0.0044442667,
0.02175955,
0.003989032,
0.00871168,
0.01015271,
0.01847138,
0.0030752884,
0.031204844,
-0.0013665219,
0.034191705,
0.0006677044,
0.015261815,
-0.0019110019,
-0.015445218,
-0.015851326,
0.009975855,
0.030654632,
-0.014606801,
-0.0010668533,
0.00050558854,
0.02335778,
-0.0026642673,
0.031021439,
-0.022859972,
-0.008960585,
0.0076898583,
-0.024929814,
-0.025768232,
-0.6359395,
-0.030942837,
0.006176777,
-0.003297993,
0.008279371,
0.03783358,
0.0025692903,
0.008652728,
-0.023174377,
0.036680754,
-0.015327316,
0.02523112,
0.0049748276,
-0.0059376974,
0.012484557,
-0.0340869,
-0.016283635,
-0.016087132,
0.03537073,
-0.012405955,
-0.0032537796,
-0.02574203,
-0.030392626,
-0.0043034386,
-0.00052073575,
0.049859628,
0.004801249,
-0.02278137,
-0.02189055,
0.048942607,
-0.024680909,
0.0098710535,
0.0076898583,
0.0052106325,
0.046820365,
-0.01214395,
-0.00007870397,
0.040820442,
0.01988621,
0.026462546,
-0.009419094,
-0.0054759127,
0.010598118,
-0.014685403,
-0.017790167,
0.02675075,
0.029187402,
-0.0070282947,
0.01848448,
-0.009779352,
0.01602163,
0.0011691991,
-0.00044049657,
-0.00037642807,
0.024196198,
-0.0065304847,
0.01502601,
-0.01848448,
0.011174531,
0.011750942,
-0.010611218,
0.03720477,
-0.010303362,
-0.015405918,
-0.021523744,
0.02139274,
-0.035606533,
-0.005731368,
0.008757531,
0.012425606,
0.012360104,
0.023108875,
-0.017711565,
0.016833847,
0.0052040825,
0.022427661,
0.008809932,
0.042051867,
-0.010598118,
0.03649735,
0.008285921,
-0.014410297,
-0.01693865,
0.00074630603,
0.016126432,
-0.0038744048,
-0.004365665,
0.009104688,
0.014698503,
-0.03442751,
0.016886247,
-0.007624357,
-0.025637228,
-0.035082523,
-0.018052172,
0.0056003653,
-0.022139456,
0.019349098,
0.013729083,
-0.012622111,
-0.030969039,
-0.014423397,
0.011593739,
0.020148216,
0.013742183,
0.0037041013,
-0.05135306,
-0.010401614,
0.047318175,
0.011816444,
0.00436239,
-0.004054534,
0.0037761529,
-0.020017212,
-0.003199741,
-0.012392855,
0.018287977,
0.0012273316,
0.0022647092,
-0.04171126,
0.0022172206,
-0.0070675956,
0.0038482044,
-0.020541223,
-0.00085151754,
0.00010592797,
0.0012314253,
-0.019139495,
0.0032717923,
-0.0015302753,
0.0096942,
-0.0076898583,
0.023947293,
-0.012019497,
0.0049879276,
0.012078449,
0.0043329145,
0.0005227827,
0.012707262,
-0.0438073,
-0.025650328,
-0.0143709965,
-0.009320842,
-0.017894968,
-0.03196466,
0.002810008,
-0.023501884,
-0.0004617845,
0.0122946035,
0.0030687382,
0.006291405,
-0.010270611,
-0.01993861,
0.017777067,
0.018261777,
-0.0024743136,
-0.0028460335,
-0.017908068,
0.0043361895,
0.00873788,
0.005839445,
0.00678594,
-0.01114178,
0.006258654,
-0.042078067,
-0.023645988,
0.00018882811,
0.0062750294,
-0.010047907,
-0.029999617,
-0.014580601,
-0.023960393,
-0.018301077,
0.005227008,
-0.003540348,
0.036078144,
-0.010709471,
0.00010157826,
-0.000016272992,
0.0014524924,
0.007964964,
-0.009753151,
-0.0018635134,
-0.0032652423,
0.003835104,
0.012818614,
0.025951635,
0.008292471,
-0.006363456,
0.038462393,
-0.02178575,
0.030916637,
-0.0193884,
-0.0017177729,
-0.00055184885,
-0.03484672,
-0.0136897825,
-0.015956128,
0.007958414,
0.03358909,
0.017174454,
-0.039929625,
0.010774972,
-0.03691656,
0.032279067,
-0.0018553258,
-0.012333904,
-0.010768422,
0.009157089,
-0.00327343,
-0.015576221,
0.0013910849,
0.004090559,
-0.0010684908,
-0.0053121597,
0.014135191,
0.0054660877,
0.0041003847,
-0.0039497316,
-0.04270688,
0.012707262,
-0.022506263,
0.01598233,
-0.0024743136,
-0.010119959,
0.01654564,
0.003946456,
0.011495487,
-0.008226969,
-0.003013062,
0.01845828,
0.0009227503,
0.010316462,
-0.0037990783,
0.02517872,
0.013545679,
-0.020213716,
-0.00035452607,
0.047815986,
0.012084999,
0.0028787844,
-0.011030427,
0.01599543,
0.008200769,
0.007571956,
-0.0053252596,
0.04619155,
-0.001432842,
-0.02030542,
0.017370958,
-0.023200579,
-0.0027756197,
-0.043859705,
0.006975894,
-0.012759663,
-0.00081180735,
-0.00016518621,
0.016663544,
0.040951446,
0.010427815,
0.026030237,
-0.0145675,
0.0047914237,
0.017580563,
0.007873262,
0.021445142,
0.0045785443,
0.004545794,
0.0025365397,
0.0038645796,
-0.027929775,
-0.01598233,
-0.0119539965,
-0.00925534,
0.016283635,
0.014973609,
0.010971476,
0.023921093,
0.018183175,
-0.0021320689,
0.0140303895,
-0.012091549,
0.014960508,
0.021183137,
-0.018078372,
-0.02819178,
-0.038462393,
0.001794737,
0.009838303,
0.022912372,
0.006838341,
0.021078335,
0.011056628,
-0.0043787654,
-0.0072509996,
-0.014803305,
0.010139609,
-0.028479988,
0.013833885,
-0.022165656,
0.005675692,
0.0015646635,
-0.009065387,
0.033641495,
0.030445028,
0.010748772,
-0.0012494383,
0.008901633,
-0.012229102,
-0.040165428,
0.010912525,
-0.024903614,
0.0076047066,
-0.01600853,
0.01796047,
0.001317396,
0.0011102479,
-0.018314177,
0.002159907,
-0.0054104114,
-0.01164614,
-0.039693817,
0.0025267145,
-0.026357744,
0.033143684,
0.020606725,
-0.015327316,
0.027877374,
0.00013151443,
0.023383982,
0.031178642,
-0.047763586,
0.018942991,
-0.013860086,
-0.015576221,
0.00017869587,
0.013172321,
0.011777143,
0.0147116035,
0.01793427,
0.0098776035,
-0.019846909,
-0.0013108457,
0.0011593739,
0.012510758,
-0.027038958,
0.013506378,
0.040086824,
0.020921132,
-0.005426787,
0.002405537,
0.01309372,
-0.01502601,
-0.002654442,
-0.002954111,
0.018392779,
-0.0024988765,
-0.0070610456,
-0.011986747,
-0.017344758,
0.0069169425,
0.00052728585,
0.03492532,
0.011927796,
-0.008423474,
-0.009170189,
0.009058837,
0.016257435,
-0.0020944057,
-0.015379717,
-0.0003440868,
0.0066123614,
-0.019008491,
-0.005613466,
0.015772725,
-0.014318595,
0.0051189307,
-0.027065158,
-0.0015728512,
-0.03157165,
0.0035534482,
0.0014598613,
-0.0011298982,
0.003943181,
-0.008521725,
0.010205111,
0.004699722,
-0.012419056,
-0.0069693434,
-0.010355763,
0.011122129,
-0.009432195,
-0.019991012,
0.0058132447,
0.006514109,
-0.026436346,
-0.028663391,
0.0013542405,
0.021445142,
0.01501291,
0.0027870825,
-0.025152517,
0.006507559,
0.018025972,
-0.00679249,
-0.0023596862,
0.0063765566,
-0.04171126,
0.007617807,
0.008803382,
0.007820861,
-0.017148253,
-0.020292317,
0.017711565,
0.018628584,
-0.019977912,
-0.008154918,
0.019964812,
-0.00777501,
-0.0022466963,
0.011875395,
0.02177265,
-0.0051353057,
-0.00218447,
-0.015772725,
-0.018549982,
-0.008855782,
-0.027065158,
-0.011515138,
-0.020423321,
-0.010244411,
0.009831753,
0.010905975,
-0.007847061,
0.008030466,
-0.0001272159,
0.009163639,
-0.016873147,
-0.012687611,
0.011698541,
-0.0023056476,
0.03309128,
-0.010277161,
0.023855591,
-0.013729083,
-0.019322898,
0.020947332,
0.0038449292,
0.0038744048,
-0.0053154347,
0.0072247987,
-0.030104421,
-0.023986595,
-0.0062783044,
0.008495525,
0.024680909,
-0.0143709965,
-0.04228767,
0.009766251,
0.0041855364,
-0.00534491,
0.008796832,
-0.0058918465,
-0.02481191,
-0.01700415,
-0.0011413611,
-0.015458318,
-0.005675692,
0.052689284,
-0.03309128,
-0.020685326,
-0.012753113,
-0.0004744754,
0.013506378,
-0.015785825,
-0.016820747,
-0.03827899,
0.014580601,
-0.029030198,
-0.030340225,
-0.011095929,
0.0040479833,
0.041999467,
0.017868768,
0.036156744,
-0.012916866,
0.025034616,
0.027798774,
0.01995171,
0.00558399,
-0.01596923,
0.014777104,
-0.02086873,
0.015667923,
-0.009995506,
0.0057444684,
0.01650634,
-0.017763967,
0.0021124186,
0.016977949,
-0.0041560605,
-0.027877374,
0.0010627594,
-0.025270421,
-0.027379565,
0.03783358,
-0.009825203,
-0.0013886286,
-0.03589474,
-0.0027281311,
0.033693895,
0.024615407,
-0.0042444873,
-0.0071527474,
0.030418826,
-0.020200616,
0.009962755,
-0.016611142,
0.003641875,
-0.0058558206,
-0.017685365,
0.014253094,
-0.006022849,
-0.0007892913,
-0.015392818,
0.02037092,
-0.016126432,
0.001969953,
0.008082867,
-0.0043460145,
-0.01552382,
-0.016598042,
0.0061243763,
-0.010264061,
-0.0051746066,
-0.00050272286,
-0.00678594,
-0.048366196,
-0.007054495,
0.013925587,
-0.014829505,
0.01211775,
-0.007840511,
0.0073034004,
0.019977912,
0.004084009,
0.015261815,
-0.02477261,
0.024707109,
0.01019201,
0.008875433,
-0.010316462,
0.0039235307,
0.011731292,
-0.010355763,
0.03482052,
0.0044540917,
-0.014999809,
-0.012078449,
-0.016781446,
0.005341635,
-0.019349098,
-0.023973495,
0.02190365,
0.02572893,
0.018628584,
-0.016047832,
0.0014156479,
-0.030418826,
0.021025933,
-0.014122091,
-0.006111276,
-0.000607525,
-0.016060932,
-0.013873186,
0.014318595,
-0.0032832553,
0.012517308,
-0.0013444152,
-0.006897292,
-0.011056628,
-0.019624205,
0.011429986,
-0.0030965763,
0.004886401,
0.03725717,
0.011279332,
-0.0037958033,
0.0030654632,
0.006831791,
0.023645988,
-0.008069767,
0.0025119768,
0.04742298,
-0.011082828,
-0.00018473428,
0.03497772,
-0.00012649948,
-0.0013190334,
0.0054529873,
0.005335085,
-0.031702653,
-0.043885905,
0.008750981,
0.017698465,
0.005004303,
-0.008285921,
0.0050599794,
-0.014947408,
-0.0077946605,
-0.016611142,
-0.015864426,
0.0121243,
-0.016467039,
-0.0012543509,
0.008331772,
-0.0011536425,
0.0145544,
-0.0067597395,
-0.005308884,
-0.010093758,
0.011187631,
-0.008809932,
0.018353479,
0.0076767583,
0.014777104,
0.0029934116,
0.00007691291,
-0.028532388,
-0.030314025,
0.023423282,
-0.00005956529,
-0.04215667,
-0.036182947,
-0.023135077,
-0.0013411401,
0.01797357,
-0.008587227,
0.030130621,
-0.017881868,
0.006026124,
-0.007382002,
-0.03144065,
0.007087246,
-0.03691656,
0.028663391,
0.030418826,
-0.011436536,
-0.001843863,
0.01654564,
-0.02182505,
0.014279294,
0.012792414,
-0.0059737233,
-0.019650405,
-0.0027739822,
-0.018563082,
-0.005482463,
-0.0014041852,
-0.007093796,
-0.016296735,
0.0036123993,
0.0011053353,
-0.000607525,
-0.025073918,
-0.016702844,
0.02716996,
-0.0059704483,
-0.02813938,
0.0048471,
-0.0021762825,
0.0036811759,
-0.017253056,
-0.0045949197,
-0.0053973114,
0.009307742,
0.010853574,
-0.027012756,
-0.002770707,
-0.000795432,
-0.03547553,
-0.012825164,
-0.020436421,
0.0057870443,
0.003933356,
0.042051867,
0.0058983965,
0.00083718915,
0.01602163,
0.008331772,
-0.016558742,
-0.014619901,
0.0022008454,
-0.015052211,
0.03348429,
0.0028820594,
-0.03298648,
0.0003068329,
0.045877144,
-0.012877566,
-0.0008273639,
0.014580601,
0.016087132,
0.017593663,
-0.019113295,
0.021065233,
0.00030478596,
0.0011495487,
0.0028312958,
-0.037073765,
0.0062291785,
0.022165656,
0.0011208919,
-0.008043566,
0.007833961,
0.008868882,
0.015641723,
-0.015209413,
-0.00031031264,
-0.012170151,
0.005649491,
-0.007827411,
0.011200731,
0.03932701,
0.0057051675,
-0.012026048,
0.013742183,
-0.011901596,
-0.013729083,
-0.022938572,
-0.01890369,
0.0062291785,
0.0030703759,
-0.0036648004,
-0.016781446,
0.0028673215,
0.008849232,
-0.0340607,
-0.004215012,
-0.025375223,
-0.007886362,
-0.038934004,
0.03107384,
0.00029782645,
-0.0043067136,
-0.0015548383,
0.0015482882,
-0.016467039,
-0.0048307246,
0.0019273772,
-0.011521688,
-0.014515099,
-0.023567386,
-0.0064617083,
0.011770593,
-0.002138619,
-0.025637228,
-0.011089379,
-0.019650405,
0.025768232,
0.17910689,
-0.019506302,
-0.0049158763,
0.013532579,
0.015091511,
0.0053580105,
0.007237899,
-0.02085563,
0.0022990974,
0.010899425,
0.028558588,
-0.0028542213,
0.0052237324,
-0.00040897404,
-0.00047897862,
0.012720362,
-0.017135153,
0.025637228,
-0.0049781026,
-0.017279256,
0.015667923,
-0.00017716068,
-0.008436574,
-0.002374424,
0.029999617,
0.0043361895,
-0.0042510377,
-0.020187516,
0.01648014,
-0.0048765754,
-0.009412544,
0.008161468,
0.007702959,
0.0071985982,
0.018707186,
0.0027346814,
-0.0123208035,
-0.02671145,
0.0022990974,
-0.021510644,
-0.005672417,
0.039720017,
-0.018301077,
-0.0010160897,
-0.0063110553,
0.006982444,
-0.005639666,
0.0057542934,
-0.021183137,
-0.009360143,
-0.05580715,
-0.0052532083,
0.008554476,
0.019008491,
0.0046440456,
-0.004696447,
0.016270535,
-0.010919075,
0.0011176168,
0.0084889745,
-0.029528009,
-0.0000029104604,
-0.032200463,
0.02618744,
-0.011888495,
0.03539693,
-0.033746295,
-0.017515061,
-0.010309912,
-0.011731292,
0.00031870502,
-0.0012592635,
-0.021432042,
-0.0046735215,
-0.01890369,
0.0029672112,
0.0077422597,
-0.010624319,
0.0147247035,
0.00073770894,
0.007722609,
-0.00058214326,
-0.04323089,
0.02038402,
-0.01700415,
-0.024379602,
0.012753113,
0.014606801,
-0.0077815605,
0.018641684,
-0.0062291785,
0.012189801,
-0.0008998248,
-0.0058558206,
-0.00727065,
-0.004323089,
0.010879775,
-0.013493278,
-0.02523112,
-0.011456186,
-0.037676375,
0.09809482,
-0.005960623,
0.008547926,
0.0030278,
0.012491107,
-0.015602422,
0.019768307,
-0.0035730987,
0.00079747895,
0.0014369359,
-0.01649324,
-0.009753151,
-0.015104611,
-0.0049813776,
0.013453977,
0.0009759701,
-0.008154918,
0.035003923,
-0.013532579,
0.0041527855,
-0.020082714,
0.0069955443,
-0.00436239,
-0.007978064,
0.0014377546,
-0.032095663,
0.006707338,
-0.0059278724,
-0.058636807,
-0.00055512396,
-0.013401576,
0.0050174035,
0.022493163,
0.0022630717,
-0.0022892721,
0.0067335386,
-0.0063274303,
-0.006163677,
0.016401539,
-0.029239802,
-0.009405994,
-0.006445333,
0.007729159,
-0.005580715,
-0.02190365,
-0.0041560605,
0.007047945,
-0.002156632,
0.007899463,
-0.018615484,
-0.008940934,
-0.003445371,
-0.008213869,
0.014580601,
-0.022584865,
-0.0037499522,
-0.044278912,
0.0025070643,
0.01701725,
-0.013309875,
0.029894816,
0.005865646,
-0.02474641,
-0.024969114,
0.0013673407,
-0.16286255,
0.024327202,
0.019545604,
-0.032226663,
0.025650328,
0.010984576,
0.027012756,
0.019060893,
0.0004425435,
0.009451845,
0.033143684,
-0.0024382877,
-0.035318326,
-0.00533836,
0.0126548605,
0.004329639,
0.006595986,
0.04695137,
0.012969268,
0.0026151414,
0.0034355458,
-0.0123142535,
0.0122946035,
-0.015248714,
0.019283598,
0.025886133,
-0.005649491,
-0.0042641377,
-0.0009907079,
-0.0055446895,
-0.018418979,
-0.00093994435,
0.020960432,
0.017711565,
0.017253056,
0.014659202,
0.015445218,
-0.0009841578,
-0.008940934,
0.020790128,
0.04063704,
0.02664595,
0.0072575496,
-0.0013624281,
-0.025755132,
0.031624053,
0.019624205,
0.0034289956,
0.012563159,
0.0056331162,
0.02863719,
0.012818614,
0.0075588557,
0.023082675,
0.02481191,
0.016624242,
-0.01794737,
0.006212803,
0.0034584713,
-0.013820785,
-0.008508625,
-0.032226663,
0.027510567,
-0.0073361513,
0.020462621,
-0.008678929,
-0.007964964,
0.0026953805,
-0.018536882,
0.020436421,
-0.016087132,
0.0020207167,
-0.015746525,
0.0043427395,
0.020108914,
0.0036844509,
-0.015157012,
0.0145413,
-0.0014909744,
0.003969382,
-0.0029344605,
-0.017501961,
-0.026174339,
-0.010938725,
0.002616779,
-0.0021582695,
0.02572893,
0.019362198,
-0.01692555,
0.0011405422,
0.025781332,
-0.024156898,
0.011115579,
-0.008318671,
0.017750867,
0.020737728,
0.015563121,
0.019270496,
-0.010414715,
-0.0005137762,
0.013440877,
-0.0063831066,
0.0009956205,
-0.013702882,
-0.00303435,
0.0021828325,
-0.013133021,
-0.020279218,
0.029816214,
-0.014253094,
-0.011698541,
-0.009379793,
0.006520659,
0.038934004,
-0.020567425,
0.01648014,
0.012216002,
-0.0102182105,
-0.0041920864,
-0.02960661,
0.071370274,
0.024012795,
-0.015628623,
0.015707225,
-0.008037016,
-0.04697757,
-0.13886286,
-0.04414791,
-0.0013255836,
0.009956205,
0.017829467,
0.021484442,
0.009209489,
0.013676682,
0.0041069346,
0.025034616,
-0.014921208,
-0.007997715,
-0.0119670965,
-0.015825126,
-0.0025676528,
-0.009602498,
0.007847061,
-0.007165848,
-0.025977835,
0.026030237,
-0.0058066947,
-0.025833732,
-0.0035337978,
-0.013453977,
-0.013715982,
-0.010519517,
-0.026108839,
0.01843208,
0.002620054,
0.010735671,
0.019768307,
0.025886133,
0.0066123614,
-0.0194015,
-0.0038416542,
0.0035730987,
0.01704345,
-0.020934232,
0.029947218,
-0.010558818,
-0.019506302,
0.016218135,
0.032855477,
0.009903804,
-0.00034715715,
-0.014619901,
-0.0038121785,
0.00509273,
0.008017365,
-0.011587189,
-0.022073954,
-0.0006005655,
-0.029580409,
-0.017515061,
0.010591568,
-0.0038547544,
0.009320842,
0.038645796,
-0.0076309075,
0.006857991,
-0.0042510377,
0.00679904,
-0.005272859,
0.010755322,
0.038069386,
-0.030707033,
-0.011036977,
-0.033353288,
0.023488784,
-0.019729007,
0.01989931,
0.0038220037,
-0.011017327,
-0.006114551,
-0.024903614,
0.010539168,
-0.010807723,
-0.016729046,
0.008895083,
-0.0073034004,
-0.0068121403,
-0.009294641,
0.010951825,
-0.010041357,
0.020056514,
0.021694047,
0.009563197,
0.002426825,
-0.007978064,
-0.0075261053,
-0.03259347,
0.04454092,
0.0022941849,
-0.0032505044,
-0.0037106515,
-0.0071592974,
-0.008187668,
-0.011495487,
0.03144065,
0.019860009,
-0.007585056,
-0.015628623,
-0.036837958,
0.013702882,
0.0026397044,
0.012667961,
0.0075981566,
-0.008056666,
-0.01689935,
-0.011436536,
0.010512967,
0.002163182,
0.0044901175,
0.005482463,
0.007119997,
-0.019165695,
-0.014855706,
-0.017213754,
0.016742146,
0.021143835,
0.020763928,
0.01689935,
-0.015327316,
0.010139609,
0.010336113,
0.023947293,
0.01310682,
-0.00462767,
-0.013912487,
0.00607525,
-0.015667923,
-0.019768307,
0.010925625,
-0.05145786,
-0.015654823,
-0.0058165197,
-0.01501291,
-0.018680984,
-0.017122053,
0.030864237,
0.0021156936,
0.0068841917,
-0.022624167,
-0.02665905,
0.007925663,
-0.0007892913,
-0.0050730794,
-0.025466925,
-0.043938305,
0.0045294184,
0.0050567044,
-0.011194181,
0.039536614,
0.01991241,
-0.000885087,
-0.018969191,
-0.009464945,
0.0045687193,
0.010323013,
-0.01746266,
-0.010198561,
-0.027536767,
0.0011667428,
0.038121786,
0.02031852,
0.00388423,
0.014213793,
-0.008855782,
-0.030392626,
-0.015746525,
0.009746601,
-0.01695175,
-0.03636635,
0.012091549,
0.029423207,
0.004061084,
0.014947408,
-0.0051189307,
0.0006550135,
-0.0064355074,
-0.009353593,
0.029554209,
0.0242879,
-0.009844853,
-0.014855706,
0.030261623,
0.04034883,
-0.00029884992,
-0.011220382,
0.022584865,
0.009635248,
0.00080935104,
-0.00017439734,
0.013820785,
0.009903804,
-0.0048274496,
0.025873033,
0.035292126,
0.006170227,
0.0043001636,
-0.0021664572,
0.028401386,
0.007912563,
-0.00035391198,
-0.014488898,
-0.0051713316,
-0.007814311,
0.014633002,
-0.018654784,
-0.013886286,
-0.017868768,
0.010938725,
0.012956167,
0.005967173,
0.013545679,
0.002770707,
-0.03052363,
0.025335923,
0.0034158954,
0.0014639552,
0.0060949004,
0.019283598,
0.024694009,
0.015301115,
0.007912563,
0.012982368,
0.029737612,
0.018156974,
0.028532388,
-0.018654784,
0.021235537,
-0.0021320689,
0.038016982,
-0.017803267,
-0.046794165,
-0.014659202,
-0.014200693,
-0.029973418,
0.013729083,
0.015314216,
-0.0027985452,
0.066706575,
0.00026323355,
-0.013637381,
-0.009936554,
0.002813283,
0.0074540535,
-0.0014991622,
0.026580447,
0.0046309456,
-0.023672188,
0.042916484,
-0.015340416,
0.011449636,
-0.041999467,
-0.02140584,
0.019204997,
-0.012026048,
0.015222514,
0.007460604,
-0.023436382,
0.037623975,
-0.02030542,
-0.00025320365,
0.010047907,
-0.031886056,
-0.015327316,
0.03725717,
-0.015956128,
0.013650482,
-0.02769397,
-0.009779352,
0.000705777,
-0.02671145,
-0.011502037,
0.00825317,
-0.010028257,
-0.004948627,
-0.02672455,
0.0041396855,
0.006753189,
-0.016060932,
0.004470467,
-0.004093834,
-0.029790014,
-0.025087018,
0.0036386,
-0.03298648,
-0.0018176625,
-0.019781407
] |
Disadvantaged family socioeconomic status (SES) is often assumed to diminish parent training program effectiveness. In examining effects of SES, influences of initial problem severity have been largely ignored. In the present meta-analysis, we examined (a) whether there is a differential influence of SES on parent training effectiveness at immediate posttreatment and at 1-year follow-up-controlling for levels of initial problem severity--and (b) whether SES interacts with initial problem severity in its effect on program effectiveness. Seventy-five studies on parent training program effectiveness to reduce disruptive child behavior were included. Separate analyses were conducted for immediate posttreatment and approximately 1-year | [
-0.013121829,
-0.0058790874,
-0.0064907265,
-0.03951923,
-0.025374662,
0.02335592,
0.009438626,
0.005808899,
-0.040749196,
-0.021256963,
-0.03050842,
0.027380036,
-0.0057186577,
0.02573563,
-0.011571007,
0.009973392,
0.036898877,
-0.019238219,
-0.011985451,
-0.0006091323,
-0.019746248,
0.016149944,
-0.01509378,
-0.01840933,
-0.014371845,
0.016390588,
0.030267775,
-0.018623238,
-0.019291695,
-0.008442624,
-0.009231404,
0.004037486,
0.0012901238,
-0.015494855,
-0.019866569,
-0.013342421,
0.00078334915,
-0.007820957,
0.034893505,
0.008516154,
0.027059177,
-0.009525525,
-0.019331804,
0.0010010158,
-0.009645848,
0.0045856214,
-0.014518906,
-0.012252834,
-0.0023279048,
0.010354414,
0.00021265318,
-0.006677895,
-0.030053869,
-0.0106418505,
-0.014973458,
-0.005203945,
-0.014304999,
0.015267579,
0.022847893,
-0.010354414,
0.0168184,
-0.0026253685,
-0.022941476,
0.0099399695,
-0.010294252,
0.011417261,
-0.010815649,
0.018797036,
-0.0069653317,
0.036176942,
0.03066885,
0.03906468,
-0.008990759,
-0.011804967,
0.015976144,
0.012593747,
-0.014505537,
-0.0003697408,
0.00921135,
0.014278261,
0.008669899,
-0.00655423,
-0.033529848,
-0.0005965987,
0.007861065,
0.008683268,
0.014665967,
0.0065141227,
-0.012673962,
0.0068717473,
-0.0040441705,
0.019144636,
0.027460251,
0.0049699848,
-0.0028125367,
0.027540466,
-0.0064940685,
0.0330753,
0.0076003666,
-0.007854381,
-0.011925289,
0.000031151183,
-0.011865128,
-0.011062979,
-0.014358476,
-0.000030028383,
-0.02351635,
-0.0026270396,
0.0015708761,
-0.023382658,
-0.027567204,
0.018877251,
-0.0015499868,
-0.0031434235,
0.0069653317,
-0.003429189,
0.0001756791,
0.011323677,
-0.0022008978,
0.008395831,
0.02669821,
0.0077674813,
0.034759812,
-0.021270331,
0.0068650628,
-0.011089717,
-0.046765316,
0.018476177,
-0.008429254,
-0.011123139,
-0.0120322425,
0.020200798,
0.02018743,
-0.002653778,
-0.04419844,
0.023917425,
-0.020093845,
-0.012045612,
-0.030936234,
-0.025789106,
0.011089717,
0.0049131657,
-0.0020839176,
-0.031230355,
0.0048429775,
0.021644667,
0.025388032,
0.03417157,
-0.0070455465,
-0.0040308014,
0.01461249,
-0.007874435,
-0.023142014,
0.0032286518,
0.005885772,
0.0046892324,
0.007774166,
0.0014447047,
-0.018235533,
-0.021791728,
-0.013155252,
-0.00072945474,
-0.009057605,
0.0071658688,
0.0019084474,
0.013068353,
0.011103086,
-0.007961334,
0.014853135,
-0.016230159,
-0.019305065,
0.014438692,
-0.03128383,
0.009672586,
0.004127728,
0.0103410445,
-0.010066977,
-0.0047259973,
0.008081656,
-0.033155512,
-0.011898551,
0.024759682,
0.026163444,
0.015040304,
-0.00632027,
0.0074065137,
0.017887933,
0.018355854,
0.0010411232,
-0.020080475,
0.0032587324,
0.011584376,
-0.005658496,
-0.017379906,
-0.6370137,
-0.008375778,
0.0043550036,
0.0028559866,
0.0035227733,
0.012593747,
0.022032373,
0.027700897,
-0.003589619,
0.033529848,
0.018543024,
0.0077607967,
-0.005715315,
-0.0073463526,
0.007607051,
-0.012079035,
-0.009786224,
-0.019358542,
0.039893568,
-0.020307751,
-0.0033188935,
0.048048757,
-0.0004054615,
0.012339734,
0.026297135,
0.01983983,
0.0053342944,
-0.02938541,
-0.0030063896,
-0.0051972605,
-0.0024315156,
0.026872009,
0.007159184,
0.044519298,
0.04510754,
-0.011470738,
0.0039405595,
0.020214168,
0.006303558,
0.029064551,
-0.021323808,
-0.00801481,
0.030749064,
0.014411953,
0.012065666,
0.027099283,
-0.0074533056,
-0.014318368,
0.011203355,
0.0065141227,
0.005010092,
-0.019893307,
-0.0067881905,
-0.0024749655,
0.015080411,
-0.016617864,
-0.0020939445,
-0.032861393,
-0.006082967,
0.018141948,
0.008095025,
0.007653843,
0.0054880395,
0.014652598,
-0.005354348,
0.03128383,
-0.018797036,
0.009866439,
-0.011250147,
0.019318433,
0.0088370135,
0.043423027,
-0.000402537,
0.017059047,
0.012546956,
0.015000196,
0.029331934,
0.010260829,
-0.029492363,
0.008175241,
-0.022032373,
0.0045889635,
0.0054713283,
-0.008315616,
0.009906546,
-0.01143063,
-0.00745999,
0.025334556,
-0.012814338,
-0.0036430957,
0.0099332845,
-0.019425387,
-0.016243527,
-0.022433449,
-0.0131285135,
0.021404022,
0.007847696,
0.018984204,
0.026163444,
-0.014973458,
-0.02461262,
0.0088370135,
-0.014973458,
-0.004064224,
-0.0014279933,
0.011925289,
0.027513728,
0.0005376908,
0.034278523,
0.00031250407,
0.027941542,
-0.0016235171,
0.00066135556,
-0.010554951,
0.01191192,
-0.03572239,
-0.010214037,
-0.015013565,
-0.0024799788,
-0.005581624,
0.00007911826,
-0.015829084,
0.005274133,
-0.0058189263,
0.020401336,
0.023930794,
-0.0028760403,
0.0063536926,
-0.01748686,
-0.011885182,
-0.0082354015,
0.0037801296,
0.0185965,
-0.008596369,
0.012165934,
-0.006049544,
0.033155512,
-0.0020120584,
-0.010140507,
-0.017192738,
-0.006661183,
0.013369159,
-0.004221312,
0.010046923,
-0.023957532,
-0.024813158,
0.01088918,
0.009886493,
-0.0107354345,
0.00242316,
-0.01381034,
-0.007881119,
-0.020254275,
-0.0013887213,
-0.020361228,
-0.021818466,
-0.0121325115,
-0.034572642,
-0.034251783,
-0.023409396,
0.0058556916,
0.010615112,
-0.045776,
-0.01557507,
-0.008603053,
-0.007513467,
-0.012065666,
0.021631299,
-0.018155318,
-0.00833567,
-0.009144505,
-0.035963036,
0.0026220263,
0.01167796,
-0.015187364,
0.023155382,
-0.018569762,
0.0034793236,
-0.03002713,
0.0012040598,
0.020949472,
-0.010882495,
-0.01909116,
-0.0043316074,
0.03018756,
-0.002804181,
0.01574887,
-0.005481355,
-0.012600432,
0.023075167,
-0.012079035,
-0.0016970476,
-0.006590995,
0.02177836,
-0.0077073197,
0.005691919,
-0.008322301,
0.009846386,
-0.01143063,
0.032273147,
0.022888,
-0.013823709,
0.03542827,
-0.002100629,
0.011230093,
-0.01525421,
0.007894488,
-0.0134293195,
0.009177927,
0.02365004,
-0.0046558096,
-0.013917294,
0.009131135,
-0.034866765,
-0.008295563,
0.011296939,
0.0036196997,
0.014505537,
-0.001010207,
0.0059024836,
-0.011952028,
-0.027727636,
0.031390782,
-0.002214267,
-0.020481551,
0.00906429,
0.005340979,
0.013522903,
0.008509469,
-0.00018821268,
0.015240841,
0.028957598,
0.023208858,
0.023302443,
0.00017745468,
-0.0016577756,
0.047727894,
-0.015882561,
0.03540153,
-0.0031484368,
0.0075736283,
0.021978896,
0.012406579,
0.012279572,
0.017874565,
-0.000986811,
0.024358606,
0.0026036436,
-0.025174126,
0.009859755,
0.0040475125,
0.024746312,
-0.0035361424,
0.009960023,
0.0035160887,
-0.004064224,
0.011417261,
0.0006296038,
0.03767429,
0.028208924,
0.004973327,
0.005274133,
0.0070455465,
0.011878497,
0.010327675,
-0.006096336,
-0.01715263,
-0.005076938,
-0.0006479864,
-0.039626185,
-0.008228717,
-0.010528212,
0.024104593,
-0.02398427,
0.010441313,
-0.0078075887,
-0.0067347134,
0.0004666672,
0.029412149,
-0.0016201749,
-0.0033422897,
-0.015214102,
0.024091223,
0.017700765,
-0.011022871,
-0.0058924565,
0.0041143587,
-0.021230225,
0.0035528538,
-0.021190116,
0.017914673,
0.026805162,
-0.010782226,
0.0045989905,
0.0044385605,
0.005732027,
0.005424536,
-0.0027724293,
0.020561766,
0.0042279963,
0.0072861915,
0.008857068,
-0.04494711,
-0.014438692,
0.014077724,
-0.01826227,
-0.023462873,
-0.03446569,
-0.010468051,
-0.006059571,
0.027313191,
0.00159845,
-0.009097712,
0.02050829,
0.028556522,
-0.0043917685,
0.0040207743,
-0.013556327,
0.05288839,
-0.003414149,
-0.0018048364,
-0.030856017,
0.003773445,
0.010394521,
0.06310243,
0.03874382,
-0.002769087,
0.028663475,
0.01748686,
-0.02131044,
-0.0067012906,
-0.02893086,
0.008556262,
-0.015160626,
-0.0005410331,
-0.02239334,
0.019599186,
-0.015374532,
0.00007682044,
0.026765056,
0.022513663,
-0.03526784,
-0.0059392485,
-0.006243397,
-0.004532145,
0.0060428595,
0.03540153,
0.014238154,
0.03002713,
-0.017112523,
0.016417326,
0.029946916,
0.006123075,
-0.016470803,
-0.026965592,
0.0038235793,
0.010942657,
0.047567464,
-0.017272953,
0.005478013,
-0.00093417,
0.007145815,
0.0047794743,
0.004107674,
0.019572448,
0.004244708,
0.008990759,
-0.018863883,
0.0048730583,
0.0030331279,
0.011156563,
0.015494855,
0.0026236973,
-0.026658103,
0.0039372174,
-0.010307621,
0.004441903,
-0.013496165,
0.026577886,
-0.022821154,
0.009706009,
0.0072861915,
-0.022700831,
-0.012446687,
-0.03385071,
-0.0039171632,
0.026604626,
-0.0058222683,
-0.026684841,
-0.030454943,
0.0011154892,
-0.0067815054,
0.010548266,
0.0019886624,
-0.0015357821,
-0.012747493,
-0.033262465,
-0.011985451,
0.014639229,
-0.002341274,
0.026938854,
-0.007881119,
0.008449309,
0.030080607,
-0.0198532,
-0.019652663,
0.006751425,
-0.011022871,
0.020481551,
0.025334556,
-0.007861065,
-0.012740808,
-0.02034786,
0.0085428925,
0.0035495115,
0.0041945735,
-0.0013837079,
-0.0062701353,
-0.015454747,
0.015080411,
0.009806278,
0.03066885,
0.007486729,
-0.012927976,
-0.003429189,
-0.01858313,
-0.012974768,
-0.010748804,
-0.0060094367,
0.021096531,
-0.017553706,
-0.006333639,
-0.013890556,
-0.030882755,
0.027059177,
-0.017433383,
0.00528416,
-0.005157153,
0.023329182,
0.0015366176,
-0.020829149,
0.026738318,
0.006707975,
-0.0032687592,
-0.012480109,
-0.019813092,
0.036016513,
0.02097621,
-0.028315878,
0.009104397,
0.026310503,
-0.023970902,
-0.033797234,
0.0036531226,
-0.009318303,
0.042353496,
-0.009712693,
-0.026631365,
-0.02970627,
-0.0024849924,
-0.019960154,
0.0038336061,
0.0026855296,
-0.017420014,
0.021644667,
-0.03625716,
-0.016123205,
-0.05037499,
0.06871747,
-0.027406774,
-0.029118028,
0.00690517,
-0.012780916,
0.018101841,
-0.010227406,
-0.000023918261,
-0.02461262,
0.011504161,
-0.00009013737,
-0.05957297,
0.003542827,
0.032861393,
0.02049492,
0.01955908,
0.021256963,
0.011417261,
-0.008121763,
0.010120453,
0.0014747853,
0.011183301,
-0.0055582277,
0.0027323219,
0.012373156,
0.026631365,
0.020762304,
-0.011938659,
0.031417523,
-0.009505472,
0.0059392485,
0.015214102,
-0.026430827,
-0.024960218,
0.018997574,
-0.030909494,
0.0018616553,
0.017687397,
0.000003835147,
0.026805162,
-0.034118094,
0.006347008,
0.009732747,
0.008469362,
0.0065040956,
0.017420014,
0.02983996,
0.005053542,
0.021484237,
-0.0034225045,
-0.0022877972,
-0.0044619567,
-0.023970902,
-0.033930924,
-0.0074800444,
0.016256897,
0.0006128924,
0.045027327,
-0.0049766693,
-0.0035027196,
0.007119077,
0.0071057077,
-0.0075067827,
-0.0015650272,
0.003058195,
-0.01858313,
0.00214575,
-0.023222229,
-0.0068984856,
-0.02446556,
0.008041549,
0.0015474801,
-0.015160626,
0.015067042,
-0.020668719,
0.0028526443,
-0.010214037,
0.009726062,
0.018502915,
-0.019438757,
0.013014875,
0.018984204,
-0.009746117,
-0.01494672,
0.00754689,
0.012052297,
0.00093751226,
0.042674355,
-0.0033523166,
-0.005294187,
0.0103410445,
0.015815714,
0.0028593289,
-0.022152696,
-0.012185988,
0.0051203878,
-0.018449439,
0.004649125,
-0.010374467,
0.0059927255,
-0.016858509,
0.01586919,
-0.010829018,
0.012440002,
-0.012921291,
0.011624483,
-0.010160561,
0.035160888,
-0.017767612,
0.03414483,
0.015882561,
0.005491382,
-0.0007850203,
-0.0015182351,
-0.0033807259,
-0.012165934,
0.011250147,
0.04037486,
-0.015374532,
-0.0012600432,
-0.022767676,
0.001350285,
-0.0016268594,
-0.012326364,
-0.023436135,
0.027513728,
-0.004548856,
-0.019612556,
0.005711973,
-0.0013160266,
-0.0015182351,
0.015321055,
-0.01509378,
-0.04890438,
-0.019331804,
-0.014264892,
0.006707975,
0.027995018,
0.00026132527,
0.019920046,
-0.01669808,
-0.0037333376,
0.0023596564,
-0.03465286,
0.028342616,
-0.014117831,
-0.0048563466,
-0.004949931,
-0.014492168,
0.031765122,
-0.00754689,
-0.006253424,
-0.00024189822,
0.022019004,
-0.010374467,
-0.000058751186,
-0.0033840681,
-0.0168184,
-0.017272953,
0.022941476,
-0.04369041,
-0.020535028,
0.021805098,
-0.0007482551,
-0.008736745,
-0.024438823,
-0.0059392485,
-0.0014313356,
-0.013489481,
-0.010093715,
-0.013188675,
0.010661904,
-0.0032537188,
-0.008442624,
-0.0020906022,
0.014986827,
-0.012299626,
-0.0065976796,
0.01953234,
-0.015775608,
0.0037868142,
-0.017687397,
0.042968474,
-0.013235467,
-0.040080737,
0.017727504,
-0.017928042,
0.0075067827,
-0.019505601,
0.0015349465,
-0.0137301255,
-0.017928042,
-0.002317878,
0.027139392,
-0.011103086,
0.00036180284,
-0.00738646,
-0.012774231,
0.004879743,
-0.0069519626,
-0.0056818924,
-0.008830329,
-0.02365004,
-0.014692705,
-0.04144439,
-0.009946654,
-0.005207287,
0.046177074,
0.026230289,
-0.023088537,
-0.0029595974,
-0.0061798934,
-0.054225307,
0.03173838,
0.0073797754,
0.019117897,
0.0072661377,
0.0023045086,
0.0065241493,
0.0045555406,
0.0041477815,
-0.008810275,
-0.030481681,
-0.0063102427,
-0.019037683,
-0.0044251913,
0.016123205,
-0.016764924,
-0.018543024,
-0.017206106,
0.033610065,
-0.013643227,
-0.012045612,
0.0063971425,
0.017847827,
0.014184677,
0.012145881,
0.029064551,
0.029465625,
-0.021658037,
0.013402581,
-0.014866504,
0.008770168,
0.0061331014,
-0.019104527,
-0.02399764,
-0.005688577,
0.009846386,
-0.026751686,
-0.0077273734,
-0.015708761,
0.009819647,
-0.010829018,
-0.0067146597,
0.006286847,
0.007025493,
0.004187889,
0.0154280085,
0.018021626,
-0.011056294,
-0.022286387,
0.008629791,
0.012165934,
0.0015566713,
0.004167835,
-0.018690083,
-0.013944033,
-0.027139392,
-0.0072527686,
-0.022700831,
0.005919195,
-0.016016252,
0.012667278,
-0.013362474,
0.013609803,
0.015441378,
-0.02351635,
-0.0024732943,
0.0038670292,
-0.014398584,
-0.0081418175,
-0.011905235,
0.023917425,
-0.029519102,
0.0057554226,
-0.0024081196,
-0.008863752,
0.013014875,
0.01811521,
0.005909168,
-0.013837079,
0.039144896,
0.18256924,
0.008529523,
-0.009084343,
0.017567074,
0.007025493,
0.001719608,
0.031069925,
0.015615177,
-0.021912051,
0.0077808504,
0.008295563,
0.00567855,
-0.015494855,
0.009418572,
0.014438692,
-0.015922667,
0.0056150467,
0.0055114357,
-0.0011639524,
0.019612556,
0.014665967,
-0.022326495,
-0.018342486,
-0.01096271,
0.019946784,
0.004488695,
-0.016925355,
-0.002769087,
0.025174126,
0.005711973,
-0.016310373,
-0.020321121,
0.021404022,
0.021163378,
-0.017059047,
-0.021283701,
0.008308932,
-0.03179186,
-0.01040789,
-0.011858444,
0.015989514,
0.010762173,
0.0055348314,
-0.018649977,
-0.013222097,
0.017740874,
0.006978701,
0.012312995,
-0.030214299,
-0.0119319735,
-0.018141948,
-0.011831705,
0.018222163,
-0.006647814,
-0.030749064,
-0.0017229503,
0.012854446,
0.002917819,
0.014117831,
-0.009057605,
0.008643161,
0.017420014,
-0.0125335865,
0.009679271,
-0.01446543,
-0.005541516,
-0.0096391635,
-0.011571007,
-0.013061668,
-0.013850449,
-0.0015767252,
-0.022620616,
-0.013008191,
0.0036297266,
-0.019024312,
-0.016952094,
0.044733204,
0.014010878,
0.013643227,
0.03320899,
-0.010608427,
-0.0030799198,
-0.04419844,
0.02097621,
0.006106363,
-0.03350311,
0.026738318,
-0.0010177272,
-0.024265023,
0.0036898877,
0.013081722,
0.017914673,
-0.012172619,
0.0005932564,
0.010254145,
-0.014813027,
0.004324923,
0.010374467,
-0.015521593,
-0.0027590601,
-0.013944033,
0.09058942,
0.0058155837,
0.008803591,
0.007112392,
-0.007881119,
0.026257027,
0.01668471,
0.011992135,
0.012961399,
0.0034459005,
-0.047246605,
0.005701946,
-0.016644603,
-0.018061733,
0.0067915325,
-0.0032754438,
-0.04334281,
0.028476307,
-0.01938528,
0.018877251,
-0.021243593,
-0.0021390654,
0.049840223,
-0.0005807228,
-0.0019903334,
-0.03385071,
0.008843699,
-0.028449569,
-0.025869321,
0.011497476,
-0.045374922,
0.006704633,
-0.01461249,
-0.013235467,
-0.017727504,
0.0076337894,
0.022580508,
-0.00089155574,
0.019278327,
0.00015008969,
-0.013001506,
0.0032403497,
0.009164558,
0.00094336126,
-0.037701026,
-0.00032482878,
0.017928042,
-0.03494698,
-0.014371845,
-0.026604626,
0.014411953,
0.02989344,
-0.02461262,
0.010742119,
-0.031952288,
-0.028503045,
-0.02858326,
0.0012600432,
0.024960218,
-0.026150074,
0.014050986,
0.012941346,
-0.01017393,
-0.014117831,
-0.0033439607,
-0.16823749,
0.010120453,
0.015414639,
-0.0031467658,
0.016484173,
-0.021029687,
0.070268296,
0.024438823,
-0.0330753,
0.0054980665,
0.018449439,
-0.012847762,
-0.037620813,
0.008703322,
-0.005254079,
0.013228782,
-0.012105773,
0.0057988726,
0.009946654,
0.013643227,
0.020575134,
-0.021484237,
0.014010878,
0.022273019,
0.012500163,
0.028101971,
-0.012740808,
0.018101841,
-0.0064305654,
-0.03703257,
-0.035053935,
0.0010870798,
0.034545906,
-0.010107084,
-0.016925355,
0.019518971,
0.0070321774,
-0.022593878,
-0.002643751,
0.014960089,
0.01875693,
0.001004358,
-0.010280883,
0.021337178,
0.01088918,
0.011577691,
0.014545645,
-0.007500098,
0.008282194,
-0.005528147,
-0.038476437,
-0.013208728,
0.016858509,
-0.0009124451,
0.019692771,
-0.018195424,
0.0031668195,
-0.013690018,
-0.0028877382,
-0.011343731,
-0.005641785,
-0.011898551,
0.019184742,
0.022700831,
0.006173209,
-0.032674223,
0.0057988726,
-0.015160626,
-0.018061733,
0.011056294,
-0.025294447,
0.004756078,
0.0029044496,
-0.022246279,
0.0075402055,
0.0029027786,
-0.024024379,
0.019264957,
-0.0056852344,
0.004869716,
0.0049131657,
0.012500163,
-0.019465495,
-0.0054412475,
-0.0049432465,
0.019585818,
0.018342486,
0.0073196143,
0.006647814,
-0.0081418175,
0.02208585,
-0.031337306,
0.018863883,
-0.023770364,
0.030722326,
-0.0054546166,
0.004485353,
0.0092380885,
0.0034893504,
-0.010575004,
0.008863752,
-0.018569762,
-0.02319549,
0.009291565,
0.022700831,
-0.007974703,
-0.010969395,
-0.00082596333,
0.03098971,
-0.01731306,
-0.012112457,
-0.0067347134,
0.013649911,
0.00818861,
0.005491382,
0.040936362,
0.011624483,
-0.0008543728,
-0.0019886624,
-0.0043215803,
0.068877906,
-0.0022343206,
-0.00842257,
0.016149944,
0.019679401,
-0.0381021,
-0.13187338,
-0.011123139,
0.013703387,
0.012145881,
0.012513532,
0.023783732,
0.0078075887,
0.018516285,
-0.025160756,
0.02620355,
-0.013395897,
-0.013850449,
-0.014211415,
-0.02684527,
0.021337178,
-0.00810171,
0.044893634,
-0.02983996,
-0.022781046,
0.040775932,
0.0043884264,
-0.014786289,
-0.004428534,
-0.00084016804,
0.007968019,
-0.0023513008,
-0.01731306,
0.002297824,
0.011029555,
0.024799788,
0.010107084,
-0.0020989578,
0.0060729403,
0.00061372796,
-0.0018532996,
-0.0056250733,
0.008516154,
-0.01828901,
0.016604494,
-0.014037617,
0.005758765,
-0.01954571,
0.016297005,
-0.009111081,
0.0016636247,
-0.017059047,
-0.02256714,
0.013155252,
0.041203745,
-0.026658103,
-0.027192868,
-0.01812858,
-0.020775672,
-0.0056217313,
0.00033360228,
0.0056986036,
0.010788911,
-0.0071524996,
-0.0041979156,
-0.008429254,
0.012012189,
-0.0026855296,
-0.015655285,
0.02336929,
0.013315682,
-0.031123402,
-0.010949341,
-0.039947044,
-0.009318303,
-0.039385542,
-0.011504161,
0.0184227,
-0.0024365291,
0.010314306,
-0.055027455,
0.010628481,
-0.034091353,
-0.005554885,
0.017834457,
-0.016938724,
-0.008589684,
-0.02049492,
0.009518841,
-0.029599316,
0.0055782814,
-0.009518841,
-0.010073661,
-0.003943902,
-0.0057052886,
0.0005447932,
-0.009739432,
0.032487053,
-0.0046591517,
-0.0038803983,
0.0064907265,
0.012687331,
-0.0063069006,
-0.027674157,
0.033262465,
0.005909168,
-0.008068287,
0.002872698,
-0.03780798,
0.011156563,
0.0016502555,
-0.018235533,
-0.009726062,
0.02637735,
0.022152696,
-0.016925355,
-0.01525421,
-0.01715263,
-0.009445311,
0.01938528,
-0.016163312,
-0.010501474,
-0.019331804,
-0.007607051,
-0.0052908445,
0.007419883,
0.019452125,
0.008088341,
-0.007399829,
-0.015214102,
0.010468051,
0.01874356,
-0.022527032,
0.012359787,
0.009191296,
-0.014452061,
-0.008161872,
-0.000056505585,
-0.006370404,
-0.0074666752,
-0.01637722,
0.020441443,
-0.008863752,
-0.0014054328,
0.045000587,
0.015147257,
0.043262597,
0.04053529,
-0.0075669438,
-0.018048365,
0.012493479,
-0.015882561,
0.0010302608,
0.0145322755,
-0.0069720163,
0.0017563732,
-0.013308997,
0.0028944227,
0.025615308,
0.007119077,
-0.008074972,
0.002850973,
0.009706009,
-0.009953339,
0.0040475125,
0.01159106,
-0.035856083,
-0.029331934,
-0.0113370465,
-0.012887869,
0.032032505,
0.015588439,
0.004869716,
-0.032005765,
-0.0035628807,
-0.0010937643,
-0.022125958,
-0.0134360045,
-0.007827642,
-0.0063737463,
0.011918604,
0.018529654,
0.004996723,
0.005528147,
0.0046324134,
0.009070974,
-0.00071232545,
0.01921148,
0.01017393,
0.01223278,
-0.015013565,
0.010361098,
0.03064211,
-0.0042547346,
-0.021952158,
0.0005869896,
-0.012486794,
0.008957337,
-0.025722262,
0.02131044,
0.00795465,
0.0048262663,
-0.004973327,
0.032139458,
0.02510728,
0.005852349,
0.0061464706,
0.0018900648,
0.004371715,
-0.0074533056,
0.0069252243,
-0.002710597,
-0.013295628,
-0.0032119404,
-0.023262335,
-0.01905105,
-0.03050842,
-0.0037433645,
-0.028315878,
-0.0027206237,
-0.000020236519,
-0.011203355,
-0.008382462,
0.034064617,
-0.011704698,
-0.029171504,
-0.016470803,
0.0014589095,
-0.012353103,
0.023756994,
0.03066885,
0.0033740413,
0.0086364765,
0.0018382593,
0.029572578,
-0.007921226,
0.008663215,
0.0033623434,
0.008275509,
0.01310846,
-0.01747349,
-0.014545645,
0.0058690608,
-0.015922667,
0.0013377514,
0.009218034,
0.013141883,
0.062835045,
-0.003933875,
-0.00068308046,
0.0034074644,
-0.005264106,
0.019933416,
-0.009077659,
0.030053869,
-0.0004395111,
-0.027941542,
0.00038394553,
-0.029679531,
0.029786484,
-0.0141312005,
-0.00034028688,
-0.014893242,
-0.006273478,
0.040802673,
-0.0023813813,
-0.0007779179,
0.024545776,
0.0071658688,
0.038556654,
0.0113370465,
-0.030749064,
-0.02239334,
-0.013068353,
0.014518906,
-0.0014856478,
-0.036765184,
-0.011022871,
0.025374662,
-0.031069925,
-0.020481551,
0.015387901,
-0.03481329,
-0.0061331014,
-0.002229307,
-0.0077808504,
-0.0015265908,
0.003302182,
-0.0033372762,
-0.008823644,
-0.025628677,
-0.042968474,
-0.017366536,
-0.00873006,
-0.0145322755,
-0.011925289
] |
Despite its key role in determining the stability and intensity of malaria transmission, the infectiousness of human populations to mosquitoes has rarely been estimated. Field-based analyses of malaria transmission have frequently relied on the prevalence of asexual parasites or gametocytes as proxies for infectiousness. We now summarize empirical data on human infectiousness from Africa and Papua New Guinea. Over a wide range of transmission intensities there is little relationship between the infectiousness of human populations to vector mosquitoes and mosquito-to-human transmission intensity. We compare these data with the predictions of a stochastic simulation model of Plasmodium falciparum epidemiology. This model predicted little variation | [
0.007301189,
-0.0040968526,
0.008945298,
-0.032909036,
0.017461115,
0.007509219,
-0.0046404153,
0.005435628,
-0.034251165,
-0.022829637,
0.011770483,
0.014078947,
0.014548693,
0.00034769563,
0.0010686712,
0.010186769,
0.04810195,
-0.009710313,
0.016253198,
-0.017461115,
-0.020158798,
0.024064396,
-0.028265264,
-0.014266845,
-0.013683018,
0.051054638,
0.0135085415,
-0.034653805,
-0.035432238,
-0.0074219806,
0.024332823,
-0.0064657126,
-0.010032424,
-0.0024544208,
-0.03800913,
-0.024332823,
0.012817345,
-0.003633818,
0.004751141,
0.009824394,
-0.0011919795,
0.017568486,
-0.011112839,
-0.0022782662,
-0.0072273714,
0.026426546,
0.0014352406,
0.0049793036,
-0.030573728,
0.016078722,
0.0021625075,
-0.00061276637,
-0.013756836,
0.009180171,
-0.015971351,
-0.006170444,
0.004667258,
0.0027043927,
0.01544792,
-0.021098288,
-0.007965543,
-0.00026590956,
-0.0288558,
0.0015610653,
0.002637286,
0.023970447,
-0.0001839138,
0.0063583422,
0.0056101047,
0.014360794,
0.033016406,
0.02689629,
0.002105467,
-0.0077776453,
0.026010485,
-0.004986014,
-0.009294252,
0.017796649,
-0.014266845,
0.0066502555,
0.008442,
0.0030399251,
-0.008697004,
0.013575648,
-0.009750577,
0.014629221,
0.021916987,
0.011790615,
0.019783001,
0.0042780405,
-0.004757852,
0.0086701615,
0.009327806,
0.019393783,
0.0236886,
-0.0008254101,
-0.020534594,
0.03637173,
0.015380813,
-0.0019980965,
-0.025701795,
0.001114807,
-0.026856028,
-0.014736591,
-0.022614896,
0.0033435822,
0.0251381,
-0.007824619,
0.01349512,
-0.01854824,
-0.016910842,
0.02030643,
-0.0019846752,
-0.02245384,
-0.012864319,
-0.0035063154,
-0.00664019,
-0.0003277734,
-0.012287203,
-0.0026842605,
0.01893746,
0.011965091,
0.0011164846,
-0.004734365,
0.021715669,
0.021916987,
-0.024359666,
0.005583262,
-0.009193593,
-0.0148573825,
-0.0090459585,
0.022413576,
0.011394686,
-0.007012631,
-0.0140655255,
0.009898211,
-0.03427801,
-0.013266958,
-0.013079059,
-0.01740743,
-0.0051135165,
0.02121908,
-0.0045364005,
-0.011931539,
0.022789372,
0.024950203,
0.050356727,
0.014240002,
0.005952348,
-0.0051739123,
0.019930635,
0.0082071265,
0.026949976,
0.0041337614,
-0.0077038277,
0.009945186,
-0.008918456,
0.018038232,
-0.019541416,
-0.0019897083,
-0.011488635,
0.003606975,
-0.0042243553,
0.015608976,
0.0010074365,
0.02018564,
-0.0074622445,
-0.007656853,
0.018185865,
-0.033687472,
-0.0153673915,
0.033043247,
-0.013521963,
0.033902213,
-0.007824619,
0.015582133,
0.0006626768,
0.016441096,
-0.0029342324,
-0.03210376,
-0.026386281,
0.024950203,
0.027835783,
0.003209369,
-0.0065563065,
-0.004657192,
0.038062815,
-0.007871594,
0.0106699355,
0.003254666,
0.018279815,
-0.009482151,
0.008106467,
-0.004130406,
-0.6553891,
0.0023671824,
0.01742085,
-0.014253424,
0.009958607,
-0.011830878,
0.028775273,
-0.014964753,
-0.010884677,
0.035995934,
-0.015850559,
0.013407881,
0.023030955,
-0.042948168,
-0.028614217,
-0.023930183,
-0.022333048,
-0.010314272,
0.012837476,
-0.0050195674,
-0.0018655611,
0.0228699,
0.017689276,
0.03221113,
-0.014951332,
-0.020386958,
0.017836912,
-0.032291654,
-0.0026674839,
0.017716119,
-0.009341227,
0.02574206,
-0.009267409,
0.03256008,
0.041525513,
-0.041096028,
0.012475101,
0.027943153,
-0.00009300544,
0.030788468,
-0.015702924,
-0.037445437,
0.013152877,
0.0010661548,
-0.009656628,
0.025205206,
-0.002204449,
-0.017434273,
0.0087574,
-0.020480908,
-0.0031573616,
0.007375006,
-0.0022983982,
0.012609314,
0.0000614444,
-0.0013505187,
0.018293235,
-0.037284378,
0.010777307,
-0.0012901227,
-0.009609653,
-0.01936694,
0.0017279928,
-0.0034895388,
-0.018669032,
0.012938136,
-0.0026054105,
-0.0010971915,
-0.021205658,
-0.016535046,
0.012441548,
0.032586925,
-0.012777081,
-0.0006593215,
-0.007200529,
0.015260021,
0.009529125,
-0.0144815855,
-0.011609427,
-0.021058025,
0.00060102274,
0.007878304,
-0.021366714,
0.0055463533,
0.0027530447,
-0.024158346,
-0.008046071,
-0.0032060137,
0.005932216,
-0.0037311222,
0.028184736,
0.02719156,
-0.0074622445,
-0.015729766,
0.008535949,
0.021058025,
-0.01998432,
-0.019554839,
0.024091238,
-0.021782774,
-0.011884564,
-0.031352162,
0.013783678,
-0.022225678,
0.007925279,
0.012750238,
-0.03256008,
-0.00025919892,
0.025419949,
-0.014817119,
0.0018403962,
-0.01709874,
-0.0030382473,
-0.015944509,
0.027513672,
-0.026721815,
0.035056442,
-0.01544792,
0.011891275,
-0.027567357,
-0.0016768241,
0.01194496,
0.020480908,
-0.027124453,
0.00946873,
0.02112513,
-0.0031590392,
-0.0022614896,
0.012381152,
-0.021957252,
0.00015801487,
-0.009804262,
0.020870127,
-0.01194496,
0.025393106,
-0.009804262,
0.027540514,
-0.002383959,
0.019608524,
-0.02748683,
-0.019487731,
-0.016561888,
-0.00010275685,
-0.0057946476,
-0.00772396,
-0.033472728,
-0.0038552692,
-0.022225678,
0.0057308963,
-0.0034425643,
0.021192238,
-0.022802794,
0.008502396,
0.016736364,
-0.0028235067,
0.0019527996,
-0.003080189,
-0.01801139,
-0.009428466,
0.014307109,
0.005100095,
0.010797438,
-0.0128576085,
0.009784129,
0.009153329,
-0.001567776,
0.0015946185,
0.006599926,
0.02182304,
-0.032828506,
0.0290437,
-0.017984547,
-0.020011162,
0.031996388,
-0.011589295,
0.010314272,
-0.004603507,
0.004254553,
-0.015595554,
-0.019393783,
0.013381039,
-0.035163812,
-0.022883322,
0.0101599265,
0.03637173,
0.0022900098,
0.02802368,
-0.0056671454,
0.027728412,
0.04973935,
0.008589634,
0.0114617925,
-0.01535397,
-0.005449049,
-0.011522189,
-0.0020299722,
-0.0042444873,
0.037499122,
-0.021084867,
0.038492296,
0.039163362,
0.0035566452,
-0.0029090673,
-0.021151973,
0.026869448,
-0.0350296,
-0.0027043927,
0.00082876545,
0.0397539,
0.031352162,
0.02533942,
-0.0080192285,
-0.011052443,
-0.021151973,
0.0006035392,
0.0014662774,
-0.006542885,
0.0029375877,
0.003737833,
-0.010032424,
-0.016682679,
0.020118533,
0.032586925,
0.027057346,
-0.013313932,
0.024037553,
0.003959284,
0.013032085,
0.019541416,
-0.005992612,
-0.0022782662,
-0.0057040537,
0.03277482,
0.01091823,
0.019407203,
0.0025366263,
0.004865222,
-0.029097386,
0.033338517,
0.005120227,
0.0074018487,
0.0030533464,
-0.00084763917,
-0.01113297,
0.014025262,
-0.008576212,
0.029526867,
-0.00057250244,
-0.016306883,
0.031217951,
0.0012641189,
0.004553177,
-0.0067039407,
-0.0005355939,
0.01091152,
-0.012481811,
-0.000052820167,
0.004314949,
0.04050549,
0.017649014,
-0.0037009243,
-0.032828506,
-0.0012372764,
-0.008918456,
0.00556313,
-0.010280718,
-0.016347148,
-0.027755255,
-0.009676759,
0.031191109,
-0.027030503,
-0.0023856366,
-0.004234421,
-0.0031657498,
-0.016038457,
0.013548805,
0.005180623,
-0.008086335,
0.0031472954,
-0.008093046,
-0.034331694,
-0.017474536,
0.010542434,
0.030868996,
-0.012152989,
-0.05097411,
-0.014682906,
0.015931087,
-0.0031221306,
-0.0031909149,
0.0077709346,
-0.005657079,
-0.023165168,
-0.022520946,
-0.0076098787,
-0.0053014145,
0.018762982,
0.005190689,
-0.0044055427,
-0.0077508027,
0.00053852977,
0.00055069284,
-0.039780743,
-0.00793199,
-0.0036539498,
0.013126034,
0.002284977,
-0.011039021,
-0.010871256,
0.008106467,
0.0120657515,
-0.035110127,
-0.02700366,
0.010146505,
-0.015018438,
0.021151973,
-0.022346469,
-0.00037999064,
0.007851462,
-0.018534819,
-0.031459533,
-0.029392654,
-0.015971351,
-0.013709861,
0.05508103,
0.0039324416,
-0.011099418,
0.04235763,
0.033821683,
0.0018286526,
-0.011273894,
-0.015582133,
0.029365811,
0.010864545,
-0.009374781,
-0.013864206,
0.00664019,
0.010180058,
0.014629221,
0.015823716,
-0.008884902,
-0.022064622,
-0.0072877677,
0.021098288,
-0.0027144586,
-0.0144815855,
0.01390447,
0.037525963,
0.02080302,
0.004130406,
-0.017595328,
0.017541643,
-0.021138553,
0.008220548,
-0.020856705,
0.007945411,
0.0017447694,
0.0025752126,
-0.0018269749,
0.002229614,
-0.0005620171,
-0.024735462,
-0.00083967025,
-0.0065730833,
0.03894862,
0.023393331,
0.0016785017,
0.009300963,
0.008005807,
-0.013609202,
-0.016682679,
-0.0095761,
-0.0035398686,
-0.029822135,
0.03419748,
-0.00056705007,
-0.0072944784,
-0.025581004,
0.00049323286,
-0.013944734,
0.011012179,
-0.0060597183,
-0.027178138,
0.008012518,
-0.036667,
-0.016830314,
0.02482941,
0.004264619,
-0.019836687,
-0.011421529,
0.0047645625,
-0.0075025083,
-0.04192815,
-0.018924037,
0.016011614,
-0.039002307,
-0.021406978,
-0.005918795,
-0.007354874,
0.029338969,
0.0020131955,
-0.028077366,
0.003513026,
-0.0033435822,
-0.0106699355,
0.0108578345,
0.0033704247,
-0.02699024,
0.0035499346,
0.0072407927,
0.008690294,
-0.0064422255,
-0.011146392,
-0.005566485,
-0.010710199,
0.008884902,
-0.015743189,
-0.009253988,
-0.010629672,
0.012696553,
-0.0100190025,
0.015407655,
-0.015045281,
-0.014240002,
0.016320305,
-0.035298027,
0.00689855,
-0.02656076,
-0.0028788694,
-0.007958833,
-0.021286186,
-0.004123695,
-0.028775273,
-0.029580552,
-0.008992273,
-0.03234534,
0.018655611,
0.0050430545,
0.024171766,
0.022225678,
0.00854266,
0.0022430352,
0.01595793,
-0.0042444873,
-0.010971915,
0.023232276,
0.014347373,
0.028560532,
-0.020534594,
0.0089050345,
-0.0036539498,
-0.025419949,
-0.03953916,
-0.023621494,
0.015407655,
0.036828056,
0.019581681,
-0.023057798,
-0.01628004,
-0.009911632,
-0.0152466,
-0.000676937,
-0.011569163,
-0.006918682,
0.016884,
-0.0059489924,
0.012126147,
-0.01916562,
0.0062274844,
-0.027996838,
-0.012173122,
0.035244342,
-0.010891387,
0.007824619,
-0.008442,
-0.012783791,
-0.0029124226,
-0.008697004,
-0.0095559675,
-0.010119663,
-0.010173348,
-0.009972028,
0.03132532,
0.0027446565,
0.041283928,
0.012213386,
0.010153215,
0.028292106,
-0.002846994,
-0.00447936,
0.022010937,
0.0048383796,
-0.011730219,
0.015702924,
0.013716572,
0.007301189,
0.00231853,
0.009784129,
0.030358987,
0.012025488,
-0.015931087,
-0.02987582,
-0.027755255,
-0.01615925,
-0.0011752029,
0.0134615665,
-0.008676873,
0.015770031,
-0.04461241,
-0.0120187765,
0.057657916,
-0.033365358,
-0.002717814,
0.0013110936,
0.018481134,
-0.0024762305,
0.0009864657,
-0.021339871,
-0.002642319,
-0.009643206,
-0.0015644206,
-0.002801697,
0.004345147,
0.019957477,
-0.012421416,
0.0129515575,
-0.0057107643,
-0.0018135536,
0.002811763,
0.011139682,
-0.0035901985,
0.0006601603,
0.013132745,
-0.015635818,
-0.012891161,
-0.0057208305,
-0.035620138,
-0.037364908,
-0.009441887,
0.015233179,
0.015166072,
0.004368634,
-0.009207014,
-0.0129784,
0.026050748,
0.0030432804,
0.03637173,
-0.009193593,
0.034975916,
0.02770157,
-0.010260586,
-0.04182078,
0.0036505945,
0.0121127255,
-0.009092933,
0.026856028,
-0.0033419044,
-0.01236102,
-0.035754353,
0.031647433,
0.0071736863,
0.004861867,
-0.018293235,
0.025836008,
0.022668581,
-0.014817119,
-0.0060228095,
0.011978513,
-0.0066905194,
0.005912084,
-0.02297727,
0.00010585004,
-0.00053978804,
-0.00998545,
-0.009623074,
-0.00078304915,
0.017649014,
0.010294139,
0.007952122,
-0.0033066736,
-0.008233969,
-0.018105337,
-0.005995967,
0.00027891147,
-0.00081073056,
0.010643093,
0.0032949299,
-0.0055362876,
-0.0019276346,
0.028506847,
-0.0045766644,
0.018561661,
-0.00074488233,
0.041176558,
-0.022333048,
-0.008569502,
0.005006146,
0.0055128,
-0.018051652,
-0.007999097,
-0.0023084641,
-0.026507074,
0.0053215465,
-0.009904922,
0.030358987,
0.013079059,
0.0023420174,
-0.008462132,
-0.035298027,
0.009260699,
-0.015582133,
-0.023312803,
0.016320305,
-0.021702247,
-0.004553177,
-0.0067207175,
-0.005314836,
0.012340888,
0.013266958,
-0.016521623,
-0.024641512,
0.008911746,
-0.004885354,
0.0029375877,
0.028667903,
0.014226581,
-0.026010485,
0.0019980965,
0.0060530077,
-0.008824507,
0.02955371,
-0.0030114048,
-0.025111258,
-0.012367731,
-0.0053181914,
0.016682679,
-0.014951332,
-0.033472728,
0.013783678,
0.0090459585,
0.014495007,
-0.025621267,
-0.007562904,
0.031513218,
-0.0023722153,
0.0055765514,
0.024775725,
-0.001946089,
0.018655611,
-0.03430485,
0.019568259,
0.010884677,
-0.025836008,
-0.014172896,
-0.011683244,
0.017944282,
-0.010072688,
0.002035005,
0.0028738366,
-0.035378553,
-0.0077910665,
0.00053852977,
-0.0058885966,
0.007965543,
-0.009757287,
-0.021809617,
-0.01893746,
-0.009025826,
-0.008616476,
0.008556081,
0.0017934216,
-0.013065638,
-0.03833124,
-0.0011441661,
-0.015327128,
0.042169735,
0.001447823,
-0.010086109,
-0.02915107,
-0.0048920647,
-0.049793035,
-0.009596231,
-0.026654707,
0.004449162,
-0.0129784,
0.03172796,
0.024695197,
0.011159813,
0.011106128,
0.010723621,
-0.027137876,
-0.009207014,
0.014293687,
0.0027647885,
0.013038795,
0.019890372,
-0.031862173,
-0.0006148635,
0.033445887,
-0.011904696,
-0.015743189,
0.026762078,
-0.0033049958,
0.016508203,
-0.01986353,
0.022628317,
0.004254553,
-0.0070730266,
0.029365811,
-0.018360343,
-0.020601701,
0.009394912,
0.008227259,
0.009757287,
-0.0275942,
0.008898324,
-0.0005343356,
0.0066905194,
-0.020641964,
-0.0073884274,
0.024131503,
-0.012220097,
0.008643319,
0.007569615,
0.012428126,
0.020534594,
-0.0034056557,
0.0076233,
0.00071971735,
0.017447693,
-0.010777307,
0.0017464471,
0.030036876,
0.02069565,
-0.0072072395,
-0.01246168,
0.0076367212,
-0.011904696,
0.010924941,
-0.0004911358,
-0.046947718,
-0.0066167023,
0.022346469,
0.007281057,
-0.0070931586,
0.011965091,
0.0011735252,
0.0071871076,
-0.02657418,
0.0001613702,
0.003935797,
0.0023202077,
0.009589521,
0.012394574,
0.0027899533,
0.003348615,
0.005180623,
0.0101129515,
-0.022413576,
0.0010812538,
0.16234408,
-0.0028805472,
0.013065638,
0.023299381,
-0.01895088,
0.002561791,
0.027164718,
-0.0054624705,
0.024601249,
0.0288558,
0.023755707,
0.0075964574,
-0.009153329,
0.01009953,
-0.0134615665,
-0.0041371165,
-0.03234534,
-0.016951106,
0.01854824,
0.013683018,
0.004036457,
-0.017622171,
-0.011005469,
-0.012106015,
0.035324868,
-0.004210934,
-0.013347486,
-0.010320982,
-0.00050246005,
0.009092933,
-0.01708532,
-0.0025668242,
0.01205904,
0.004935684,
-0.018279815,
-0.009596231,
-0.0109048085,
-0.01164298,
0.027943153,
0.0039290865,
0.017152425,
0.004533045,
-0.004657192,
-0.014360794,
0.005194044,
0.017353745,
0.0038854673,
-0.009448597,
-0.014468164,
-0.009676759,
-0.024977045,
-0.022507526,
-0.034036424,
0.010562565,
-0.015488184,
0.0095761,
0.012797212,
-0.0108108595,
0.0008975496,
0.013783678,
0.004583375,
0.0007683696,
-0.014333951,
0.009354648,
-0.03658647,
0.039914954,
-0.019004565,
0.013206562,
-0.01813218,
-0.008509106,
-0.019756159,
-0.017434273,
-0.025621267,
0.007905147,
-0.006136891,
-0.006334855,
0.034895387,
0.013260247,
0.014696327,
-0.0042176447,
-0.018628769,
0.010320982,
-0.012971689,
-0.006415383,
-0.0038049393,
-0.026426546,
0.03843861,
0.007663564,
-0.02606417,
0.010059266,
-0.0012146279,
-0.0059825457,
0.006046297,
-0.013152877,
0.002697682,
-0.0029006791,
0.02307122,
-0.010891387,
-0.0061234697,
-0.01679005,
-0.017783226,
0.0653349,
0.018722719,
0.0014587279,
0.00602952,
0.01472317,
-0.002905712,
0.01626662,
0.011757062,
-0.009428466,
-0.0077373814,
-0.028775273,
0.017957704,
-0.015098966,
0.03296272,
0.0042277104,
0.02802368,
-0.0106699355,
0.02410466,
0.008945298,
-0.0022883322,
-0.027540514,
0.00803265,
0.020574857,
-0.016548466,
-0.027996838,
-0.022574631,
0.025017308,
-0.011985224,
-0.002378926,
0.0046538366,
-0.034036424,
-0.01822613,
-0.0019947411,
-0.010367957,
-0.010274007,
-0.0026221871,
-0.012387862,
-0.00096046197,
0.0073884274,
0.015031859,
-0.035351712,
0.023527544,
0.0075964574,
-0.011904696,
-0.009535836,
0.009012405,
0.02378255,
-0.013293801,
-0.008576212,
-0.015702924,
-0.030520042,
0.0034727622,
0.005569841,
0.013186431,
-0.009294252,
0.009710313,
-0.023983868,
0.018628769,
0.00218935,
-0.016333725,
0.019903792,
-0.0009529125,
-0.02029301,
0.0033066736,
-0.00043828943,
-0.17007475,
0.0063180784,
-0.0033771354,
-0.010347825,
0.043243438,
-0.003414044,
0.010247164,
-0.0044290298,
0.0063818297,
-0.011864432,
0.016830314,
0.015971351,
-0.031835333,
-0.007972254,
0.027352616,
-0.0028939685,
-0.041740254,
0.02791631,
0.035995934,
0.0175148,
0.03591541,
-0.018373763,
0.018293235,
-0.019903792,
0.011045733,
0.012340888,
-0.013441435,
-0.0015157684,
0.0029593974,
-0.032506395,
-0.019527996,
-0.003902244,
0.023755707,
0.009972028,
0.020360116,
0.0013513574,
-0.0012616025,
0.0035264473,
-0.005747673,
0.0011986902,
0.032372184,
0.028050523,
-0.009361359,
0.021447241,
0.0073481635,
0.024171766,
-0.009099644,
-0.0047612074,
0.019903792,
-0.004932329,
0.025581004,
0.008052782,
0.008415157,
-0.008931877,
0.008435289,
-0.0070797373,
0.004398832,
0.0030751561,
0.0383044,
-0.013441435,
-0.015783451,
-0.010388088,
0.0014570502,
-0.016092142,
0.012750238,
-0.0133676175,
-0.007267636,
0.022829637,
-0.010535723,
0.004066655,
-0.014884225,
-0.0148573825,
0.007160265,
-0.009314384,
0.009804262,
0.018306658,
-0.024319401,
0.019541416,
-0.003513026,
-0.0004563243,
-0.025581004,
0.017152425,
-0.019903792,
0.020346696,
-0.01009953,
-0.012850897,
0.010287428,
-0.0059892563,
-0.010441774,
0.0046504815,
-0.0033771354,
-0.016736364,
0.021997515,
-0.046813507,
0.016145827,
0.011555742,
0.0008698682,
-0.008066203,
0.020601701,
0.028694745,
0.0010124695,
-0.0023990578,
-0.030251617,
0.015125808,
0.037713863,
-0.019246148,
-0.009153329,
-0.016548466,
0.0364791,
0.007160265,
-0.017810069,
-0.019219305,
0.020534594,
0.010428352,
-0.00017510606,
0.04018338,
0.014401058,
-0.008623187,
0.026614444,
-0.019742737,
0.0689855,
-0.005459115,
-0.0058349115,
0.01987695,
-0.017139005,
0.0018890484,
-0.12862977,
0.0069388137,
-0.009636495,
-0.008079625,
-0.016937684,
0.030868996,
-0.010696778,
0.027245246,
0.0055396426,
0.021178816,
-0.030922683,
-0.0050732526,
-0.009804262,
-0.01617267,
0.019621944,
-0.012548918,
0.031191109,
-0.011253763,
-0.0024443548,
0.034546435,
0.00012834121,
-0.019447468,
-0.020319853,
0.0005016212,
0.0047544967,
0.020212483,
-0.013736703,
0.018682454,
-0.013864206,
0.025057573,
0.031835333,
-0.014951332,
-0.00022375828,
-0.03583488,
-0.023272539,
0.0019578326,
-0.011253763,
-0.010824281,
0.022078043,
-0.0128576085,
-0.016118985,
0.02019906,
0.012085883,
0.0044055427,
0.020735914,
0.0020954008,
-0.0045766644,
-0.0026054105,
0.0017347034,
-0.02853369,
-0.029929506,
-0.0288558,
-0.034331694,
-0.017997967,
0.012508654,
-0.013119324,
-0.014642642,
0.017273217,
0.011515478,
-0.010931651,
-0.019715894,
0.005274572,
-0.0075159296,
0.013669597,
-0.01142824,
-0.023863077,
-0.015340549,
-0.017071897,
-0.003533158,
-0.030171089,
-0.0043921215,
0.00854937,
-0.00231853,
-0.002254779,
-0.038680196,
0.007744092,
-0.011052443,
-0.0045598876,
0.002234647,
-0.020574857,
-0.0021725735,
-0.006878418,
0.013589069,
-0.012213386,
0.030332144,
0.020413801,
0.0007427852,
0.00802594,
0.009025826,
0.0081601525,
-0.016763207,
0.015085544,
0.004932329,
-0.017165847,
0.0053215465,
0.016803471,
-0.0055966834,
-0.02564811,
0.013474988,
0.022708844,
-0.023822812,
-0.012850897,
-0.03553961,
0.021688826,
0.0039894823,
-0.016441096,
0.004647126,
0.011099418,
0.002920811,
0.01101889,
-0.006911971,
-0.010777307,
-0.008509106,
-0.0000019529045,
-0.05293362,
0.015541869,
-0.017944282,
-0.0025282379,
0.0065261084,
0.009623074,
-0.004086787,
0.031298477,
-0.020440644,
-0.00061737996,
-0.0036505945,
0.023621494,
-0.01009282,
0.012938136,
0.003781452,
0.020266168,
-0.012676421,
0.0039324416,
-0.009488861,
-0.0047444305,
-0.0060731396,
0.0036405285,
0.009327806,
-0.015179493,
0.009072801,
0.026091013,
0.017850334,
0.050759368,
-0.023608072,
-0.0108108595,
-0.006308012,
-0.010602829,
-0.001577003,
0.015501605,
-0.013246826,
0.017595328,
0.003299963,
0.00463706,
0.044692937,
0.010643093,
-0.011294027,
-0.010341114,
-0.016575309,
-0.0144815855,
0.019085092,
-0.0035365133,
-0.0040029036,
-0.015112387,
0.023151748,
0.0033217724,
-0.0074219806,
-0.0028939685,
-0.021433821,
-0.003414044,
-0.02183646,
0.022292783,
-0.005811424,
-0.024547564,
-0.018628769,
-0.0064422255,
-0.017863754,
0.012434837,
-0.0018454292,
0.00014637609,
0.005942282,
0.024762304,
0.009347937,
0.011488635,
0.00069455244,
-0.01649478,
-0.029473182,
0.020628544,
0.0052577956,
0.0059657693,
-0.0109517835,
0.03626436,
-0.022494104,
0.016602151,
0.0027731766,
0.024440194,
0.008529238,
0.008280944,
-0.007509219,
0.0014050427,
0.0059993225,
0.010381378,
0.02274911,
0.046974562,
0.01658873,
-0.006036231,
0.014884225,
-0.044478197,
-0.003090255,
0.005066542,
-0.047538254,
-0.037311222,
0.010797438,
0.009904922,
0.004385411,
0.01801139,
-0.008837928,
-0.018373763,
-0.0066905194,
0.0028872578,
-0.0001882128,
0.013307222,
-0.034573276,
0.01998432,
0.007046184,
0.03038583,
-0.020735914,
-0.007898437,
0.015716346,
-0.0023957025,
0.019286413,
-0.020011162,
0.030332144,
-0.02367518,
0.0062241293,
0.031379007,
-0.025460212,
-0.01626662,
-0.012186543,
-0.029070543,
0.012173122,
0.010542434,
0.012783791,
0.051242534,
0.012454969,
0.00014669065,
0.008931877,
-0.018065074,
0.0037109903,
0.009750577,
0.0059590586,
0.00066099915,
-0.038787566,
0.013454856,
0.0012557306,
0.014253424,
-0.028077366,
-0.024144923,
0.033043247,
-0.039324418,
0.00865674,
-0.036747526,
-0.014696327,
0.014548693,
0.005697343,
0.009737155,
-0.0021910276,
-0.020467486,
-0.024279136,
0.031352162,
-0.011851011,
0.0039794166,
-0.0030181154,
-0.019796422,
-0.003922376,
-0.021138553,
-0.0063516316,
-0.010643093,
0.0070797373,
-0.0030164379,
-0.0348417,
0.011971802,
0.010737042,
-0.004714233,
-0.009750577,
-0.01605188,
-0.00311542,
-0.0028184736,
0.012891161,
-0.033902213,
-0.011884564,
-0.030358987
] |
Growing evidence for intratumour heterogeneity informs us that single-site biopsies fall short of revealing the complete genomic landscape of a tumour. With an expanding repertoire of targeted agents entering the clinic, screening tumours for genomic aberrations is increasingly important, as is interrogating the tumours for resistance mechanisms upon disease progression. Multiple biopsies separated spatially and temporally are impractical, uncomfortable for the patient and not without risk. Here, we describe how circulating tumour cells (CTCs), captured from a minimally invasive blood test—and readily amenable to serial sampling—have the potential to inform intratumour heterogeneity and | [
-0.04095327,
0.011792584,
0.020780874,
-0.029550906,
-0.015251653,
0.023294156,
-0.028122304,
0.0022255774,
-0.03854581,
-0.009054429,
0.022288844,
0.011468503,
0.0050695543,
-0.008135097,
0.009193321,
0.009365283,
0.04444541,
0.013300553,
-0.015278109,
-0.007228993,
-0.03542405,
0.009444649,
-0.009940692,
0.009451264,
-0.01882316,
0.030662041,
0.018571831,
-0.028730782,
-0.001641074,
-0.0058566085,
-0.0013707308,
0.01858506,
-0.033519246,
-0.02657465,
-0.012083596,
0.0020089722,
0.01906126,
-0.0031283747,
0.021111568,
0.0048645237,
0.012467202,
0.000030485946,
-0.0012293587,
0.0010896401,
-0.011442048,
-0.013902418,
-0.000065777305,
-0.01755329,
-0.028783694,
-0.0033582079,
-0.0012921907,
-0.007592757,
-0.02772547,
0.0059293616,
-0.023294156,
-0.008981677,
-0.0030638892,
0.040371247,
0.0016022173,
-0.0166538,
-0.0058599156,
-0.006547761,
-0.009001518,
0.020939607,
-0.015079692,
-0.015344248,
0.008862626,
0.017209368,
0.0054134773,
-0.0019246449,
0.010873252,
0.027937114,
-0.008379811,
-0.01232831,
0.010046515,
-0.030371029,
-0.020423723,
0.0012764827,
-0.017989809,
0.021376126,
0.013704001,
-0.015582349,
0.011164264,
0.030291663,
0.019021576,
0.033281144,
0.0011615662,
0.0036376452,
0.02675984,
0.0024024993,
0.012665619,
0.016931584,
-0.0017626043,
-0.005433319,
-0.009027974,
0.007533232,
-0.004431313,
0.031323433,
-0.008822943,
-0.034789115,
-0.0033598612,
0.012143121,
-0.012076981,
-0.01948455,
-0.026482057,
0.01154787,
0.0033119104,
-0.005277892,
0.013069067,
-0.0052547436,
0.006680039,
0.024577253,
-0.024802126,
-0.011316383,
0.04108555,
0.006825545,
0.011402364,
-0.0044577685,
-0.023704218,
-0.0084062675,
0.0077581047,
-0.014021468,
0.03452456,
-0.03830771,
0.028783694,
0.006336116,
-0.026045538,
0.0070570316,
0.0074538654,
-0.02074119,
0.002926651,
0.0068520005,
0.01073436,
0.023347067,
-0.018915754,
-0.039656945,
-0.011799198,
-0.010800499,
-0.016627345,
-0.048969317,
0.005635043,
0.030344574,
-0.013968557,
-0.008836171,
-0.006577524,
0.010959232,
0.026839206,
0.017421013,
0.0026290254,
0.00017433827,
-0.0060781743,
-0.016323106,
0.01858506,
-0.011759515,
-0.008670823,
0.0027265802,
0.0015534398,
0.0075795297,
-0.018227909,
-0.014166974,
-0.012116665,
0.011230403,
0.025397377,
0.0056747263,
0.019405182,
0.0155426655,
0.007420796,
-0.0053870217,
0.014563808,
-0.00790361,
0.018413099,
0.023016373,
-0.023915863,
0.003786458,
-0.008710506,
0.020886697,
-0.0042791935,
0.01924645,
-0.030185841,
-0.045080345,
-0.011025372,
0.034127723,
0.027937114,
-0.004666107,
-0.02531801,
-0.011719831,
0.0168919,
0.013399762,
0.0021726661,
-0.029471539,
-0.0010201941,
-0.0011822346,
0.003508674,
-0.010740974,
-0.6362043,
-0.009729047,
0.0003083731,
-0.025847122,
0.0063394234,
0.015688172,
0.021852326,
0.0059988075,
-0.009887781,
0.002624065,
-0.00824092,
0.021799415,
0.0071363985,
-0.003965033,
-0.026931802,
-0.031005964,
-0.025185732,
-0.011752901,
0.024299469,
0.0072356067,
-0.012196032,
0.009643067,
-0.007764719,
0.02140258,
0.005158842,
0.013968557,
0.01443153,
0.013161661,
-0.013584951,
0.030080019,
-0.022685677,
0.011091511,
-0.015727855,
-0.023532256,
0.047911093,
0.005982273,
0.0071826954,
0.019656511,
0.00941158,
0.016878674,
0.018730566,
-0.0019345658,
0.030000651,
0.00886924,
-0.01797658,
0.015132603,
-0.0065808306,
-0.012473816,
-0.016984496,
-0.0010144069,
0.012950016,
0.0012516807,
-0.014841592,
0.006167462,
0.000033405362,
-0.01058224,
0.010767429,
-0.01750038,
0.014762226,
0.007533232,
-0.017143229,
0.026019083,
-0.009213163,
-0.033757348,
-0.011977773,
0.03476266,
-0.0023545485,
-0.0013781715,
0.019153856,
-0.004292421,
0.016772851,
0.020582458,
-0.005843381,
-0.01407438,
0.025093136,
0.042249594,
0.019100944,
-0.0026604414,
0.014497669,
0.0045999675,
0.018333731,
-0.011091511,
-0.044948064,
0.017910441,
0.0054597748,
0.00416345,
-0.025635477,
0.03426,
0.010535943,
0.010740974,
0.0062600565,
0.02711699,
0.009226391,
-0.0406358,
-0.003442535,
0.010549171,
-0.0013202998,
0.02074119,
0.00022177234,
-0.03656164,
-0.037196573,
-0.018426325,
0.027778381,
-0.002050309,
0.0067098015,
-0.011283314,
-0.011825654,
-0.009676136,
0.031296976,
-0.035503417,
0.02314865,
0.0028836604,
-0.0042064404,
0.010304457,
-0.0017096932,
-0.024828581,
-0.021600997,
0.042143773,
-0.010979074,
-0.025701616,
0.013809823,
0.01031107,
0.027990025,
-0.018055947,
0.019973978,
0.007129784,
0.0164157,
-0.006818931,
-0.0029547599,
-0.009887781,
-0.024206875,
-0.026865663,
0.008181394,
-0.029154072,
0.009517402,
-0.006422097,
0.008776645,
-0.017209368,
-0.018333731,
-0.031720266,
-0.025344465,
-0.027566737,
0.012877263,
0.013121977,
-0.016561206,
-0.003640952,
-0.028968882,
-0.0027331943,
0.02164068,
-0.005955817,
-0.009094113,
-0.0002381004,
0.011058441,
-0.0014327362,
0.03494785,
-0.002384311,
0.000637828,
-0.029392172,
0.001540212,
-0.027143447,
-0.0223153,
0.01112458,
0.0050100293,
-0.0033433265,
-0.000256702,
-0.021574542,
-0.0014815136,
0.0012260517,
-0.002352895,
-0.028333949,
-0.0101126535,
-0.02796357,
-0.012116665,
0.022540173,
-0.0076655103,
-0.0065179984,
-0.024392065,
0.0072488347,
-0.01863797,
-0.019312588,
-0.02165391,
-0.013571723,
-0.007632441,
-0.0131484335,
0.029524451,
0.01863797,
0.026257183,
-0.0013558496,
0.0044676894,
0.02507991,
0.011699989,
0.006233601,
-0.029868374,
0.010555784,
0.00703719,
-0.007030576,
0.020172395,
0.0015832024,
-0.0007279424,
0.028254582,
0.02038404,
0.012553182,
0.011957931,
-0.013756912,
0.026733384,
-0.026945028,
0.012936789,
-0.01295663,
0.0024355687,
-0.0020453485,
-0.002961374,
0.02134967,
-0.017606203,
0.00664697,
-0.018902527,
0.036482275,
0.004054321,
-0.008181394,
0.011250244,
-0.012149734,
-0.0159395,
-0.0029779086,
0.0067627127,
0.0075464603,
-0.019034805,
0.020820558,
0.02362485,
0.0014244687,
0.013889191,
-0.004699176,
-0.017751709,
0.036667462,
0.017632658,
0.0042758863,
0.022923779,
0.020132711,
0.021309987,
-0.014325708,
0.01882316,
-0.0019444866,
0.013188117,
0.01283758,
-0.00338301,
-0.0036078824,
0.007109943,
0.006736257,
0.0316409,
0.019511005,
-0.021733277,
-0.007539846,
-0.013141819,
0.002123062,
-0.0058466876,
0.004103925,
0.012969858,
-0.01124363,
0.0026819366,
0.002951453,
0.05092703,
0.005611894,
0.019868156,
-0.004381709,
-0.0039981026,
-0.017698796,
-0.00033503538,
0.008214464,
0.045715276,
-0.016032094,
-0.019802017,
0.012401063,
-0.0021958149,
-0.022354983,
0.0062534427,
-0.031032419,
0.009497561,
0.011177491,
0.00023913382,
0.0060186493,
0.01353204,
0.0055226064,
-0.014788681,
-0.03537114,
0.011647078,
0.038730998,
-0.018227909,
-0.037487585,
-0.005843381,
-0.017209368,
-0.01073436,
0.0024008458,
0.0196036,
-0.008227692,
-0.009623225,
-0.0029531063,
-0.002756343,
0.0016303264,
0.009199935,
-0.005853302,
0.022354983,
0.008333514,
-0.0025876884,
-0.017421013,
-0.004232896,
-0.014391847,
0.026958257,
0.009609997,
-0.023651307,
-0.0023446276,
-0.015278109,
-0.020714736,
-0.018188225,
-0.024378836,
-0.009087499,
-0.014510897,
-0.0029547599,
0.0043354114,
0.011223788,
0.023360295,
0.029127616,
-0.009967147,
-0.011137808,
-0.027169902,
-0.022857638,
0.005558983,
0.03637645,
0.021786187,
-0.017249051,
0.00563835,
-0.013584951,
-0.009233004,
-0.0047355527,
-0.011799198,
0.0161776,
-0.024299469,
-0.0058665294,
0.00790361,
0.005188605,
0.011799198,
-0.002318172,
0.029974196,
-0.023082511,
-0.01761943,
-0.020873468,
0.009742275,
0.012394449,
-0.007976363,
0.015833678,
0.028175214,
0.024749214,
-0.00983487,
0.014881276,
0.027990025,
-0.0014343896,
-0.013201345,
-0.043387186,
0.007982978,
-0.0005162976,
0.010443348,
-0.005489537,
-0.0034326143,
0.012434132,
-0.0005452334,
-0.013201345,
-0.0196036,
0.0035582783,
0.022857638,
0.033043046,
0.009266074,
0.0045206007,
0.003918736,
0.012500271,
0.011375908,
-0.010059742,
-0.02026499,
0.025397377,
0.0035582783,
-0.016455384,
-0.004385016,
0.00703719,
0.0039253496,
-0.016680256,
-0.006355958,
0.009676136,
-0.0026753226,
0.00501995,
-0.024630165,
0.006359265,
-0.013128592,
-0.012698689,
-0.01349897,
-0.014643175,
-0.016521523,
-0.026614334,
-0.003087038,
-0.0074538654,
-0.018796705,
-0.020899925,
0.0010714518,
0.027169902,
0.0035715061,
0.0043354114,
-0.008882468,
-0.009934078,
0.025291555,
-0.013102137,
-0.012116665,
0.008842785,
-0.03722303,
-0.006699881,
-0.008756803,
-0.013875962,
-0.013095522,
-0.022090426,
0.037355307,
-0.0005530874,
-0.01834696,
0.006891684,
0.0077184215,
-0.0017163071,
0.02050309,
0.017897213,
-0.010092812,
0.00093586685,
-0.011673533,
0.0076390547,
-0.029630272,
-0.0028638188,
-0.025516426,
-0.000054151307,
0.000032449447,
-0.012149734,
-0.014682858,
0.0044280062,
-0.0080028195,
0.009061043,
-0.015913043,
0.0055259136,
-0.01093939,
0.005105931,
0.0113692945,
-0.013307167,
0.0015873361,
0.0058665294,
0.00032346105,
-0.0016179254,
-0.0023297463,
0.012692074,
-0.014127291,
0.0026935108,
0.0022503794,
-0.016428929,
-0.027831292,
-0.019312588,
-0.033175323,
-0.0071760816,
0.048546027,
0.0011499919,
-0.011528028,
-0.025093136,
-0.004745473,
0.011805812,
0.015793994,
-0.0023297463,
-0.013756912,
-0.014471213,
0.016667029,
0.009742275,
-0.01349897,
0.008525318,
-0.03746113,
-0.01037721,
0.035820883,
0.008565,
0.007804402,
0.0109658465,
0.00863114,
-0.019418411,
-0.013095522,
-0.038228344,
-0.036191262,
-0.0127449855,
-0.0055986666,
0.041350104,
0.035556328,
0.009590155,
0.010000217,
0.0022983302,
0.032222923,
-0.0035715061,
0.017354874,
-0.009008132,
0.0026323323,
-0.01713,
-0.002227231,
-0.010403665,
-0.0161776,
0.011031985,
-0.016534751,
0.027593192,
0.025582565,
-0.01761943,
-0.012275399,
0.01100553,
-0.03505367,
-0.033466335,
0.005039792,
0.019497778,
0.017090319,
-0.054816004,
0.0025579259,
0.003316871,
0.018492464,
0.0134328315,
0.0046131955,
0.03217001,
0.0055854386,
-0.0049207415,
-0.02791066,
0.0073678847,
-0.0065246127,
-0.02657465,
-0.01031107,
-0.006144313,
0.026442373,
-0.006699881,
-0.0049901875,
0.030238751,
-0.017778164,
0.0065246127,
0.015780766,
-0.006025263,
0.0029283043,
0.0031961673,
0.0067164158,
-0.0073282016,
0.0027232734,
-0.014219886,
0.0038889733,
-0.0030688497,
0.0067164158,
-0.024458203,
0.018889299,
-0.014484441,
-0.0015757617,
0.024749214,
0.027355092,
0.0061376994,
-0.009325599,
0.017579747,
0.003703784,
0.004424699,
-0.023862952,
0.0073678847,
-0.021680364,
0.024497885,
0.029762551,
0.028836604,
-0.0020073187,
-0.009887781,
0.015502982,
0.01497387,
-0.016190827,
-0.032222923,
0.011746286,
-0.006154234,
-0.0016170986,
-0.018413099,
-0.029841917,
-0.018439554,
0.030582674,
-0.008908924,
0.021098342,
0.0039418843,
-0.02243435,
-0.01726228,
0.011461889,
-0.012248943,
0.012711916,
-0.01295663,
-0.014907731,
-0.025026998,
0.004355253,
-0.01563526,
0.0016807574,
-0.003991489,
0.009643067,
-0.014008241,
-0.0032193158,
0.032857858,
-0.00715624,
0.0010276347,
-0.01580722,
-0.005552369,
0.044418953,
-0.023426434,
-0.011541256,
0.0027315407,
-0.003978261,
0.005502765,
0.0031912068,
0.00077589316,
-0.011580939,
-0.009266074,
0.0057375585,
0.021190936,
0.029365717,
0.0053374176,
-0.002847284,
-0.00929253,
-0.017910441,
-0.048625395,
-0.008902309,
0.02075442,
-0.043016806,
-0.017143229,
0.025635477,
0.012407676,
0.036402907,
0.010807113,
0.0056548845,
-0.020913152,
0.05010691,
-0.03457747,
0.006094709,
0.013968557,
0.009550472,
-0.02338675,
0.014418302,
-0.005492844,
-0.018466009,
-0.0075200046,
-0.024458203,
-0.02009303,
-0.014920958,
-0.009867939,
0.0198417,
0.0002130916,
-0.021759732,
-0.0043354114,
0.026773067,
0.015913043,
-0.014709314,
-0.051561967,
0.011342838,
-0.029894829,
0.009094113,
0.015688172,
-0.027513824,
-0.0050563267,
-0.011991001,
0.009113954,
0.018029492,
-0.0063956412,
-0.013624635,
0.00835997,
0.018320503,
-0.0021842406,
0.021257075,
0.016905129,
-0.010397051,
-0.017156458,
-0.0013616367,
0.018849615,
-0.0015666676,
-0.018201454,
0.0020552694,
-0.014907731,
0.013704001,
-0.018836388,
0.022394666,
-0.014709314,
-0.025410604,
-0.042143773,
0.011911634,
-0.036244173,
0.023505801,
0.022328528,
0.001130977,
-0.028889516,
0.0016683564,
-0.026680473,
-0.04619148,
0.042646427,
0.020608913,
-0.00014633255,
0.038625177,
0.0061079366,
0.035450503,
0.003010978,
0.017698796,
-0.0062633636,
-0.017368102,
0.03336051,
-0.016931584,
0.010205248,
0.012063754,
-0.045583,
-0.01906126,
0.01623051,
0.009907623,
-0.0072025373,
0.029656729,
0.008684051,
0.035159495,
0.00089535676,
-0.004054321,
-0.00863114,
0.009682749,
0.012162962,
-0.008102028,
-0.0016600889,
0.004371788,
-0.00396834,
0.008730348,
0.009027974,
0.010079584,
0.027408002,
0.016852217,
-0.01683899,
-0.02886306,
0.0038129133,
-0.007500163,
0.01100553,
0.0337838,
0.010707905,
0.013875962,
0.0023231325,
-0.0012243983,
-0.020013662,
-0.018571831,
-0.008611298,
-0.012255557,
-0.0018337038,
-0.011177491,
-0.00026558942,
-0.0051522283,
-0.002119755,
-0.0142860245,
-0.01648184,
-0.0100399,
-0.018320503,
-0.020212078,
0.026270412,
0.00497696,
-0.003244118,
-0.013995012,
0.00058326335,
-0.02652174,
-0.009914236,
-0.005175377,
-0.009497561,
-0.034312915,
0.04751426,
-0.015251653,
0.000754398,
0.0039881817,
-0.009570314,
0.00941158,
-0.026005855,
-0.011071669,
0.19630055,
-0.030662041,
-0.007361271,
0.02616459,
0.010033286,
-0.029603817,
0.021323213,
0.0047124038,
0.008366584,
0.017698796,
0.02928635,
-0.0098282555,
-0.00019004628,
-0.00031602042,
0.024484659,
-0.011415591,
-0.023426434,
-0.0138362795,
-0.021548087,
-0.014365391,
-0.0055854386,
-0.012850808,
0.007017348,
-0.018069176,
0.027672559,
-0.012288626,
0.00030031241,
-0.0057772417,
0.020053346,
-0.0052249813,
-0.030609129,
0.0027993333,
-0.012010843,
-0.011739673,
0.0071826954,
0.020516317,
-0.023069283,
0.008895696,
-0.013373306,
-0.0078837685,
-0.010509487,
0.017421013,
0.0020701508,
-0.010879866,
0.0077713327,
0.00556229,
0.0050728614,
0.0011235363,
0.00992085,
-0.008644368,
-0.038651634,
0.012367994,
0.005029871,
0.0036376452,
-0.012910333,
0.008016047,
0.020198852,
-0.005228288,
-0.015026781,
0.016336333,
-0.011660306,
-0.004110539,
-0.01797658,
0.0259794,
-0.007400954,
0.038757455,
-0.015278109,
0.014815136,
0.030476851,
-0.012784669,
0.02248726,
-0.00037368535,
-0.020304674,
-0.006422097,
0.00995392,
-0.012771442,
0.037805054,
0.008875854,
0.013584951,
0.0040278654,
0.02375713,
0.004967039,
0.007996205,
0.020899925,
-0.017672341,
-0.029497994,
0.026601106,
0.0030754635,
-0.014934187,
-0.004232896,
0.0031862464,
0.0013120325,
-0.002579421,
-0.007672124,
0.0140479235,
0.011342838,
-0.001952754,
0.0048083053,
-0.010985688,
-0.03156153,
-0.03145571,
0.075663015,
-0.00050348317,
0.008955221,
0.0060550254,
0.0016708365,
-0.020159168,
0.008684051,
0.010998916,
-0.009762117,
0.009576928,
-0.037249487,
0.008756803,
-0.0040708557,
-0.0036707146,
0.04336073,
0.013002927,
-0.04592692,
0.034921393,
-0.0049901875,
0.008300445,
-0.022831183,
0.021984603,
0.022341754,
-0.0002843977,
0.0004658666,
-0.021812642,
0.0075795297,
0.011858723,
-0.028333949,
-0.022474032,
0.006183997,
-0.0044048573,
0.011957931,
0.01906126,
-0.009484333,
-0.006293126,
-0.024061369,
-0.039895047,
0.0024322618,
0.0017014258,
0.000081433645,
-0.020529546,
0.01563526,
0.019418411,
-0.013783368,
0.02206397,
0.015291337,
0.0006494023,
-0.028545594,
-0.00038773988,
-0.020886697,
-0.022235932,
0.011924862,
0.033968993,
-0.021680364,
-0.015225198,
-0.016005639,
0.003981568,
0.011428819,
-0.02291055,
0.0003625244,
0.021759732,
-0.008148325,
-0.008068958,
0.0148548195,
-0.16518877,
0.0046131955,
0.018518921,
-0.027328635,
0.033598613,
0.012110051,
-0.0034160793,
-0.006937981,
-0.01031107,
-0.012420905,
0.023294156,
0.008254147,
-0.02170682,
-0.016547978,
0.016534751,
-0.009788572,
-0.017936897,
0.04066226,
0.029974196,
0.008908924,
0.023585169,
-0.031349886,
0.03926011,
-0.011012143,
0.01154787,
0.00029287176,
-0.011151035,
-0.00076266535,
-0.004685948,
0.009199935,
-0.015397159,
-0.014206657,
0.011329611,
-0.012692074,
0.014325708,
0.0058367667,
-0.008042502,
-0.024511114,
-0.010813727,
0.0069445954,
0.032487478,
0.039577577,
0.016124688,
-0.014868047,
-0.013221187,
0.017725252,
0.0011020411,
-0.013452673,
0.010569013,
-0.0011235363,
0.019272905,
-0.01599241,
0.012844194,
0.0050001084,
0.010416892,
0.006303047,
0.013730457,
0.0080491165,
0.0070504174,
-0.005820232,
-0.0070041204,
-0.011852109,
0.024193646,
0.006951209,
-0.03494785,
-0.03325469,
0.007982978,
-0.011587553,
-0.000055029715,
0.006465087,
-0.019339044,
-0.0023743901,
0.0083269,
-0.017659113,
0.030873686,
-0.0051522283,
-0.008439337,
0.00455367,
-0.00983487,
0.0010797192,
-0.01070129,
0.020886697,
-0.02616459,
-0.016256966,
-0.011475117,
-0.014682858,
0.0013434484,
0.0077779465,
0.0012243983,
-0.010873252,
0.015410387,
-0.013756912,
-0.0051290793,
-0.008862626,
0.0045900466,
0.021958148,
-0.0077118077,
-0.00012380394,
-0.005347338,
-0.021243848,
0.011078283,
-0.0073215873,
-0.010899708,
0.01996075,
0.029127616,
0.025106365,
0.009689364,
-0.009517402,
0.041323647,
0.0023595088,
-0.044313133,
-0.0053539523,
0.0002395472,
0.018704109,
-0.0057309447,
0.041588206,
0.014127291,
-0.0227915,
0.0016394205,
-0.0323552,
0.059683833,
0.0010036593,
-0.020251762,
0.017354874,
0.014550581,
-0.0055556763,
-0.14825718,
-0.007083487,
0.008545159,
0.02050309,
0.009061043,
0.0126259355,
-0.014788681,
0.0020106256,
-0.0061079366,
0.03476266,
-0.032487478,
-0.009537244,
0.008895696,
-0.015701398,
0.0014691126,
0.0013905725,
0.0019643283,
-0.00971582,
-0.010284615,
0.024246559,
0.013849507,
0.0053341105,
0.010602082,
-0.022183022,
0.016878674,
0.016098233,
-0.035688605,
0.026376234,
0.028915972,
0.006465087,
-0.008531931,
-0.009867939,
-0.0026009162,
-0.019021576,
0.0026852435,
0.008273989,
-0.022235932,
-0.04066226,
0.0028720861,
0.009867939,
-0.030238751,
0.03288431,
0.013155048,
0.009464491,
-0.00703719,
-0.024921175,
-0.012282013,
-0.0044610756,
0.021442264,
-0.036508728,
-0.012711916,
-0.028122304,
-0.02470953,
-0.0030027106,
0.0024620243,
-0.0022024286,
0.017672341,
0.0044048573,
-0.0055986666,
-0.021561315,
-0.008664209,
-0.011078283,
-0.016759623,
0.03084723,
0.017831074,
-0.007400954,
-0.018386642,
-0.010959232,
0.016852217,
-0.004904207,
0.0004261832,
0.0051522283,
-0.010972461,
-0.009967147,
-0.025000542,
-0.012030684,
0.0066701183,
-0.0036244174,
0.017817847,
-0.021759732,
0.0015170634,
-0.016071778,
0.008677437,
-0.017182913,
0.019775562,
0.010873252,
0.00096893637,
-0.011316383,
0.007189309,
-0.019511005,
0.011871951,
0.034868483,
-0.021971377,
-0.041588206,
-0.019114172,
-0.00004115603,
-0.0023743901,
-0.0023975389,
0.022447577,
0.0325933,
-0.015317793,
-0.009947306,
-0.03463038,
0.012533341,
-0.008273989,
-0.009041201,
0.024484659,
-0.009861325,
0.014338936,
-0.006898298,
0.00063700124,
0.034894936,
-0.012440746,
0.014907731,
-0.012943403,
-0.000102153754,
-0.022950234,
-0.02375713,
0.00023851378,
-0.0026984713,
0.012374607,
0.0396834,
0.007149626,
-0.014365391,
0.016905129,
0.0015509595,
0.0069644367,
0.008677437,
-0.0046297302,
0.047805272,
-0.0110386,
-0.02213011,
0.025212187,
-0.006898298,
-0.010198634,
-0.007169468,
-0.0001959368,
-0.0035219018,
0.013247642,
0.004355253,
0.015211971,
0.041350104,
-0.022619538,
-0.019788789,
0.029497994,
0.0055920524,
-0.03251393,
0.021151252,
-0.03206419,
0.02904825,
0.00083789846,
0.020198852,
0.04275225,
0.0050596334,
0.0073678847,
-0.032672666,
-0.027804837,
-0.005049713,
-0.0023247858,
-0.008426108,
-0.03637645,
-0.031217609,
0.031667355,
0.028042937,
0.003710398,
0.028254582,
0.011792584,
-0.0042593516,
-0.037831508,
-0.017632658,
0.017831074,
-0.02357194,
-0.007764719,
0.0038757455,
0.012030684,
-0.0030473545,
0.014828364,
-0.016349562,
-0.008016047,
0.010866638,
0.017950125,
0.013141819,
0.011898407,
0.007553074,
-0.009563699,
0.0013905725,
0.035926707,
8.396553e-8,
0.0053043477,
0.017751709,
0.0011045213,
0.002053616,
0.0078837685,
0.022156566,
0.014206657,
0.015211971,
-0.019272905,
0.026548196,
-0.018796705,
0.01377014,
0.007109943,
0.034233548,
0.0020585763,
0.0023892715,
0.023228018,
-0.01648184,
-0.014960642,
0.0065345336,
-0.009781959,
-0.017368102,
-0.00025112153,
0.02484181,
0.0009788573,
0.010893093,
0.004828147,
-0.009583541,
-0.02633655,
0.029021794,
-0.0023578554,
0.004573512,
-0.020436952,
0.019709423,
0.021905238,
0.014788681,
0.00055060716,
0.0062997397,
0.022222705,
-0.0033052966,
0.026733384,
-0.017526835,
0.014299252,
0.002815868,
0.02014594,
-0.00715624,
-0.024735987,
0.0012235715,
0.0015426922,
-0.020529546,
0.0081218695,
0.01599241,
-0.016018866,
0.057779033,
0.010013445,
-0.015317793,
0.016561206,
-0.04365174,
0.0225534,
0.015648488,
0.016878674,
-0.022857638,
-0.040847447,
0.0110386,
0.0012847501,
0.008082186,
-0.037196573,
-0.013717229,
0.039577577,
-0.01329394,
0.0020420416,
0.017566519,
-0.0039981026,
0.019497778,
-0.03158799,
0.013942102,
0.0168919,
-0.017712025,
0.004176678,
0.022897322,
-0.0028886208,
-0.028545594,
-0.018055947,
0.009980375,
-0.003584734,
-0.034021903,
-0.009934078,
0.00020358412,
-0.00050348317,
0.0043519465,
-0.027381547,
0.0075266184,
0.0038062995,
0.0025909953,
0.009239619,
-0.009616611,
-0.030900141,
-0.034233548,
-0.02002689,
-0.0014128945,
-0.013545267,
0.0052811992
] |
Increased lipid supply causes beta cell death, which may contribute to reduced beta cell mass in type 2 diabetes. We investigated whether endoplasmic reticulum (ER) stress is necessary for lipid-induced apoptosis in beta cells and also whether ER stress is present in islets of an animal model of diabetes and of humans with type 2 diabetes. Expression of genes involved in ER stress was evaluated in insulin-secreting MIN6 cells exposed to elevated lipids, in islets isolated from db/db mice and in pancreas sections of humans with type 2 diabetes. Overproduction of the ER chaperone heat shock 70 kDa | [
-0.024349995,
-0.020972414,
0.003930691,
-0.040530957,
-0.016154781,
0.011939352,
-0.022294646,
0.015513303,
-0.010964043,
-0.0148718245,
-0.0026886452,
0.015120561,
0.0018262495,
0.016442792,
-0.012829567,
0.01046657,
0.03406381,
0.034666013,
0.026601715,
0.023433596,
-0.03416854,
0.007377001,
0.0153169315,
-0.0023809974,
0.016743895,
-0.022595748,
-9.860096e-7,
-0.032623757,
-0.013706691,
-0.025776956,
0.010793855,
0.0009867639,
-0.027177736,
-0.008646866,
-0.004699811,
-0.004978003,
0.009347256,
0.008502861,
0.020959323,
-0.021050964,
0.013097941,
0.024782011,
0.006254414,
0.0068664365,
-0.0042514303,
0.010833129,
0.009491261,
-0.010990226,
-0.0078875655,
0.01594532,
0.015853679,
0.019414539,
-0.011540065,
-0.03856725,
-0.0075733718,
0.0010031281,
0.0037179561,
0.000354695,
0.010446933,
-0.015722765,
0.008640321,
0.0057929424,
-0.027806122,
-0.0007503006,
0.0000024226752,
0.02318486,
0.008188668,
0.007553735,
0.003740866,
0.010374931,
0.025043838,
0.009445441,
-0.01858978,
0.021640075,
-0.00018317725,
-0.011310965,
0.0066897026,
-0.014649271,
0.025541311,
0.0037965046,
0.03639408,
-0.008646866,
-0.012626651,
0.031471714,
0.022477925,
-0.032231014,
-0.020147657,
0.01652134,
-0.018877791,
-0.005511477,
-0.0075602806,
0.008581409,
0.017699566,
0.01337286,
0.007939931,
0.011232417,
0.0063100522,
0.019571636,
-0.019401448,
-0.030267306,
-0.0151467435,
0.0021126238,
-0.009046154,
-0.00718063,
-0.012155361,
0.0066733384,
0.013117578,
0.00048560894,
0.010702215,
0.0050074584,
-0.008830146,
0.018602872,
-0.016115507,
-0.030764777,
0.025043838,
0.010021463,
0.027151553,
0.00041872007,
-0.02177099,
-0.014138706,
0.010132739,
0.0156704,
0.020409485,
-0.017516287,
0.004218702,
0.0038194144,
0.00028678335,
-0.0031730267,
-0.0069122566,
0.0046376265,
0.012508828,
0.0059991316,
0.021626985,
-0.013071758,
-0.012148814,
0.019388355,
-0.01708427,
-0.0013901425,
-0.008496315,
-0.04469402,
0.01136333,
0.025318757,
-0.01539548,
0.002973383,
-0.008679595,
0.039640743,
0.00961563,
0.022320827,
-0.020304753,
0.028513057,
-0.014688545,
-0.019977469,
0.015984593,
-0.0149765555,
0.023669241,
0.019493086,
-0.018498141,
0.0065849717,
-0.031497896,
-0.027832305,
0.028827252,
0.006421329,
-0.0001916662,
0.020069107,
0.033540152,
0.020488033,
-0.00013480046,
0.0011667706,
0.021757899,
0.002660826,
-0.0011438606,
0.015539486,
-0.017909028,
0.023734698,
0.0001829727,
0.027649026,
-0.005704575,
0.012600468,
-0.0149765555,
-0.021613892,
-0.032204833,
0.016403519,
0.013202672,
0.014675453,
-0.017948302,
0.0048307246,
0.013667416,
-0.0024513637,
0.0249522,
-0.025672225,
0.0069318935,
0.0049223644,
-0.011651342,
-0.030267306,
-0.644725,
-0.03969311,
0.016102416,
0.015892953,
-0.021338973,
0.036760636,
0.0048339977,
0.014151798,
-0.015840588,
0.006382055,
-0.0015529667,
0.010440388,
0.00713481,
-0.025986418,
-0.0030061116,
-0.029219992,
-0.020802226,
-0.0054623843,
0.014426718,
-0.0072591784,
-0.02628752,
0.0064180563,
-0.01858978,
0.002402271,
0.013863787,
0.026130425,
0.014007793,
-0.02590787,
-0.00036267255,
0.034508917,
0.000080440484,
0.036551174,
0.010132739,
0.009543627,
0.049406923,
0.0011814984,
-0.010905132,
0.008692686,
0.016442792,
0.04066187,
-0.019872738,
0.010590939,
0.012659378,
-0.0004700629,
-0.008391584,
0.0049158186,
0.017477011,
0.024441633,
0.017594835,
0.02534494,
0.008836691,
0.00004640797,
-0.042913593,
0.006188957,
0.008097027,
0.002433363,
0.01253501,
-0.029743649,
0.013628142,
0.02580314,
0.006188957,
0.046474453,
-0.028853435,
-0.009262162,
-0.007160993,
0.004670355,
-0.01913962,
-0.0021878993,
0.020213114,
-0.0012166816,
0.023355048,
0.01093786,
-0.016743895,
0.031131336,
0.027439563,
0.011926261,
0.010590939,
0.0289058,
-0.005498386,
0.0059173102,
0.009962551,
0.0033841257,
-0.0030028387,
-0.012358277,
0.009360347,
0.015840588,
0.010329111,
0.0009000334,
-0.01474091,
0.0073311813,
-0.0025266393,
-0.0016609707,
-0.026117332,
-0.029272359,
-0.012436825,
0.017516287,
-0.009229434,
0.011814984,
0.026968272,
-0.013863787,
-0.0135757765,
0.006182411,
-0.017961394,
-0.008548681,
0.008450495,
0.01781739,
-0.03830542,
-0.005099098,
0.0425994,
-0.011886987,
0.010623666,
0.018851608,
0.0021993543,
-0.009910186,
0.006886074,
-0.016783169,
0.027020639,
0.009543627,
0.018694513,
-0.043882355,
0.011520428,
-0.010669487,
0.0093079815,
-0.021836447,
0.0071086274,
0.016351152,
-0.008882511,
-0.0110295005,
0.0035804964,
-0.013457954,
0.0031059333,
-0.0033448513,
0.0048536346,
-0.008751597,
0.02356451,
-0.0050532785,
-0.0015946955,
-0.006339508,
0.002197718,
-0.045846064,
-0.0029946566,
0.004676901,
0.0035346765,
-0.008987242,
-0.0053020148,
-0.016298786,
-0.0015701492,
-0.011939352,
0.032990314,
-0.010381476,
-0.002934109,
-0.008155939,
-0.0055507515,
0.014845641,
0.021980451,
-0.008352309,
-0.0078875655,
-0.013523411,
-0.00049338193,
-0.0011741344,
0.012973572,
0.012364822,
-0.021103328,
0.011245508,
-0.014138706,
-0.031105153,
0.011939352,
0.016377335,
-0.031000422,
-0.027518112,
-0.0057405764,
-0.013431771,
0.0012502283,
0.019466905,
-0.011566247,
0.013785238,
-0.009582901,
-0.0006766615,
-0.023538329,
0.00499764,
0.014662363,
-0.017018814,
0.0035052209,
0.008267215,
0.03762467,
0.020239297,
0.023734698,
0.0144529,
0.00499764,
0.02402271,
-0.03115752,
0.026064968,
-0.016639164,
-0.007867929,
0.013353223,
-0.025763866,
0.004863453,
0.014649271,
0.016194055,
0.0080773905,
0.015120561,
-0.01971564,
0.0064835134,
-0.032623757,
0.023826338,
-0.022477925,
-0.011828075,
-0.021208059,
0.025305666,
0.0005060642,
0.0038325058,
-0.0012445007,
-0.017699566,
-0.010067282,
0.0026395526,
0.0011675888,
0.007357364,
-0.02149607,
-0.00072329957,
-0.024310721,
-0.02402271,
-0.0041401535,
0.008790872,
-0.0121749975,
-0.015277658,
0.025083112,
0.0135757765,
0.026640989,
-0.014321986,
-0.026536258,
-0.0030650229,
0.001870433,
-0.012783747,
0.019218167,
-0.0077762883,
0.016285695,
0.015330023,
-0.003215574,
0.019885829,
0.014465991,
0.0020340756,
0.00059484027,
0.01606314,
0.010106557,
-0.0036230434,
-0.0019277079,
0.01568349,
0.012607013,
-0.02770139,
-0.0076650116,
-0.004840543,
0.021993544,
-0.010492753,
-0.0031550261,
0.004385617,
-0.010741489,
0.013078303,
0.0080773905,
0.031000422,
0.010905132,
0.030450584,
-0.012417188,
0.0105189355,
-0.0035314038,
0.0074948235,
0.01661298,
-0.00089839695,
0.017044997,
0.0021469886,
-0.0053805634,
-0.044589292,
0.01407325,
-0.0021060782,
-0.0106891235,
0.016599888,
0.016573707,
0.015827496,
-0.011612067,
0.032152466,
-0.013340131,
0.002556095,
-0.020854592,
0.018066125,
0.00036246798,
-0.0015496939,
-0.019584727,
-0.008928332,
0.0018933429,
0.0068402537,
0.0228183,
0.0024268173,
0.00909852,
0.013274674,
-0.00020485987,
-0.011932806,
-0.008293399,
0.028303595,
-0.024258355,
0.023616876,
-0.0008525771,
0.020488033,
0.023067039,
0.0009000334,
0.01098368,
0.024546366,
0.004663809,
0.0070038964,
0.014112524,
-0.009039608,
-0.027518112,
-0.0126201045,
-0.028591607,
-0.0034561283,
0.010996772,
0.02984838,
0.004621262,
0.008286853,
0.0074031837,
0.032309562,
0.017791206,
-0.0009213069,
-0.017948302,
-0.013693599,
-0.007455549,
0.03003166,
0.042075742,
-0.0016887899,
0.019545453,
0.012607013,
0.025384214,
-0.0017493377,
-0.028591607,
0.00801848,
-0.0065424247,
-0.009877457,
-0.012482645,
0.0088432375,
-0.017594835,
0.023132494,
0.0025168206,
-0.0029815652,
-0.03500639,
0.010590939,
-0.0095632635,
-0.006637337,
-0.012744473,
0.019362172,
0.030895691,
0.03893381,
-0.01595841,
-0.012881933,
0.014989647,
-0.009334165,
0.0037474118,
0.003258121,
0.016324969,
-0.005252922,
0.015762039,
0.0056849383,
-0.020815318,
0.0052463766,
0.028591607,
0.01726755,
-0.0021846264,
0.003169754,
0.00504346,
0.012161906,
0.010361839,
-0.015264566,
-0.014662363,
-0.015971502,
0.015762039,
-0.0101589225,
0.006316598,
0.042075742,
-0.012679016,
-0.016848626,
0.00020199612,
-0.0019031615,
0.0040812423,
0.023826338,
-0.010741489,
-0.00956981,
0.0001245728,
-0.0029406545,
-0.006964622,
0.006905711,
-0.0016454246,
-0.01510747,
0.008267215,
0.002282812,
-0.01868142,
-0.020488033,
-0.0054198373,
0.009681086,
-0.032178648,
-0.015696581,
0.0114746075,
-0.008404676,
0.01135024,
-0.002379361,
-0.0133008575,
0.012751019,
0.010780764,
-0.008457041,
0.0012788656,
0.02082841,
-0.03838397,
0.017594835,
0.00024525909,
-0.00097285426,
-0.03492784,
-0.022923032,
-0.0025364577,
-0.0004430619,
-0.024559457,
0.027910855,
-0.018851608,
-0.011245508,
-0.0052463766,
0.023053946,
0.018550506,
0.0039045084,
0.0010939497,
0.000532247,
-0.0153169315,
-0.035137303,
-0.012868841,
-0.0018295224,
-0.009779272,
-0.0037474118,
-0.005969676,
0.021705532,
-0.0040125125,
0.001037493,
0.005269286,
0.003459401,
-0.005069643,
0.022059001,
0.026038785,
0.0041892463,
0.029167628,
-0.008470132,
0.00014492583,
-0.014112524,
-0.04636972,
0.014505265,
-0.010446933,
-0.00021375793,
0.004149972,
0.0037866859,
-0.023433596,
-0.003973238,
0.00040726512,
-0.01641661,
0.022556473,
-0.011108048,
-0.027413381,
-0.042756494,
-0.015539486,
-0.013562685,
0.001492419,
0.002976656,
-0.0042317933,
-0.027361015,
0.0051154625,
-0.0064966045,
-0.027989402,
0.05545515,
-0.030660046,
-0.016311878,
0.018432684,
0.021221152,
0.006231504,
0.00092457974,
0.0044674384,
-0.042416118,
0.0011315874,
-0.012266637,
-0.03068623,
0.0031762996,
-0.0032532115,
0.023826338,
0.0425994,
0.045741335,
0.0034233998,
0.021064054,
0.006061316,
0.012135723,
0.037022464,
-0.010316019,
0.007304998,
-0.019126527,
0.023328865,
0.009216342,
-0.013588868,
0.026667172,
-0.022765936,
0.029953111,
0.0068402537,
0.00014134616,
-0.030529132,
-0.0048241788,
-0.03238811,
-0.025030747,
0.018105399,
-0.019558543,
-0.008005388,
-0.03068623,
-0.027544295,
0.0013369587,
-0.011998263,
-0.0059140376,
-0.022779027,
-0.00058052153,
-0.043908536,
0.051501546,
0.004110698,
-0.014204163,
-0.0035510408,
-0.022739753,
0.007913748,
-0.012469553,
0.01098368,
-0.0015570577,
-0.010113102,
0.022477925,
-0.0127902925,
0.01773884,
0.017333006,
-0.034666013,
-0.0023269954,
0.005626027,
-0.010636758,
-0.0036328621,
-0.018602872,
-0.015251475,
-0.025410397,
-0.001627424,
0.008358856,
-0.010708761,
0.010564756,
-0.011873895,
-0.006807525,
-0.0064606033,
-0.00030028386,
0.011625159,
-0.0013075031,
0.024847466,
0.02825123,
-0.0038979629,
-0.027151553,
-0.007966114,
0.018982522,
-0.0066537014,
0.024899833,
0.0025577312,
-0.0073377267,
-0.0012976845,
-0.0067551597,
0.009929823,
-0.027256284,
-0.019584727,
0.025004564,
-0.0067158854,
0.0041466993,
-0.005861672,
-0.017136635,
-0.028198864,
-0.024140531,
-0.014217255,
0.008358856,
0.002780285,
-0.010230925,
0.0004786541,
0.020592764,
-0.013457954,
0.011428787,
0.0025430035,
-0.029691283,
-0.014204163,
-0.02280521,
0.005495113,
-0.010427296,
0.015186018,
0.015500211,
-0.016482066,
0.01953236,
0.012377914,
0.021168785,
0.0072329957,
-0.010931315,
0.01253501,
0.031524077,
-0.0012215908,
-0.01248919,
0.025358032,
-0.023826338,
0.0069318935,
-0.013045575,
0.0015136926,
0.0009884003,
-0.028748702,
0.0016306968,
0.0044052545,
0.01915271,
-0.014767094,
-0.016586797,
-0.032990314,
0.0032597573,
-0.030267306,
-0.01653443,
0.0024055438,
-0.025358032,
-0.009739998,
-0.010185105,
-0.0067747966,
0.012698653,
0.0013451409,
0.019296715,
-0.013588868,
0.01735919,
-0.027937036,
0.019296715,
0.002888289,
0.015212201,
0.0013017756,
0.00891524,
-0.016835533,
-0.017634109,
-0.010774218,
-0.020357119,
-0.037310474,
-0.014911098,
-0.013719781,
0.009825092,
0.010702215,
0.009792363,
0.01290157,
0.0004843816,
0.001650334,
0.0040485137,
-0.003966693,
0.03416854,
-0.029586552,
0.014060158,
0.005825671,
0.0019064344,
-0.04074042,
-0.019401448,
-0.0089479685,
-0.02534494,
0.014047067,
-0.019113436,
-0.010440388,
0.012679016,
0.0067747966,
0.007246087,
-0.0016953356,
0.0144529,
-0.01811849,
0.009078883,
0.022909941,
-0.013248491,
-0.027622843,
0.0056522097,
0.021535344,
-0.00252173,
0.01290157,
-0.013903061,
-0.0055867527,
0.00085830456,
-0.023014672,
-0.0051318267,
-0.024101257,
0.037598487,
-0.0026002782,
-0.0023695424,
-0.011422242,
0.0057503954,
-0.03181209,
-0.0034888568,
-0.01653443,
0.012247,
-0.0013541412,
0.0240358,
-0.015788222,
0.009249071,
0.0015611488,
0.010211288,
-0.015172927,
-0.02111642,
0.0071740844,
-0.0029128355,
0.034220908,
0.008568318,
-0.021757899,
-0.02402271,
0.034849294,
0.0008468496,
0.00019279124,
0.0076584658,
-0.015500211,
0.0061333184,
0.00448053,
0.022923032,
0.011284783,
-0.0019964378,
0.015565668,
-0.034587465,
0.008836691,
0.026968272,
0.0026133696,
-0.008280307,
-0.017804297,
0.014963464,
0.02627443,
-0.011271691,
-0.001584877,
-0.010780764,
-0.0063198707,
-0.0012420461,
0.0064606033,
0.010885495,
0.005262741,
-0.00019872328,
0.028643971,
-0.012659378,
-0.013706691,
-0.015447846,
-0.021849537,
0.00076993764,
-0.0030781142,
0.0048110876,
-0.014845641,
0.000065814944,
0.010492753,
-0.025580585,
0.0067878882,
-0.018341044,
-0.003590315,
-0.022779027,
0.028041767,
-0.0069515305,
-0.011278236,
-0.024886742,
0.011108048,
-0.03631553,
-0.016285695,
-0.0016519704,
0.000115777024,
-0.0047750864,
-0.015225292,
-0.028094133,
-0.009739998,
-0.008319582,
-0.02956037,
-0.024075076,
-0.01337286,
0.014479083,
0.20024598,
-0.040059667,
0.0092032505,
0.0070104417,
0.0031026606,
-0.02262193,
-0.0028506513,
-0.0029390182,
-0.0066471556,
-0.005324925,
0.0028931983,
0.008195213,
-0.013850695,
0.0019227986,
0.010342202,
-0.0033579427,
-0.033906713,
0.014937282,
-0.00017571106,
0.016089324,
0.016848626,
0.0039634197,
0.019925103,
0.0092883445,
0.05849235,
0.018576689,
-0.022360103,
0.003698319,
0.031550262,
-0.008070845,
-0.03183827,
0.0046801735,
-0.015382389,
0.019846555,
0.00952399,
-0.00029455638,
-0.008430858,
-0.011094957,
0.022412468,
-0.00027901036,
-0.008614138,
0.0049190917,
-0.01708427,
0.011356785,
-0.015421663,
-0.016364243,
-0.025790047,
-0.020867683,
0.008627229,
-0.007933386,
-0.05210375,
-0.0005318379,
0.019820372,
0.02628752,
0.025384214,
-0.005910765,
0.00031501168,
0.013667416,
-0.0012363186,
0.008345764,
-0.0005195647,
0.0027475564,
-0.033199776,
0.016442792,
-0.03482311,
0.0289058,
-0.020016743,
-0.01294739,
0.008293399,
-0.011618613,
-0.0029095626,
-0.012770656,
-0.024140531,
-0.0075799176,
-0.013150306,
0.00623805,
0.011094957,
0.008195213,
0.012724835,
0.01135024,
0.010734944,
0.010473116,
-0.024926016,
0.01501583,
-0.011906624,
-0.034980208,
0.025227118,
-0.0033906712,
-0.011147323,
-0.02092005,
0.004303796,
0.017856663,
-0.015277658,
-0.014217255,
0.009196705,
-0.0032924858,
0.0011021318,
0.003459401,
-0.011657887,
-0.03236193,
-0.021168785,
0.094415136,
0.004329979,
0.00909852,
-0.016207147,
-0.02459873,
-0.03463983,
0.007383547,
0.0025315485,
0.0026035511,
0.017202092,
-0.021129511,
-0.012934298,
-0.026248246,
-0.021993544,
0.009576355,
0.028198864,
-0.00020087109,
0.004303796,
-0.024284538,
-0.014688545,
-0.008005388,
0.010374931,
-0.012561194,
0.012711745,
0.018903974,
-0.015002739,
-0.008928332,
-0.014060158,
-0.02271357,
0.0023809974,
-0.010191651,
-0.010119649,
0.024991473,
0.017333006,
-0.0029881108,
0.007540643,
-0.010545119,
0.028303595,
0.030660046,
-0.012050629,
-0.0024055438,
-0.0014065068,
-0.024559457,
0.00915743,
-0.0075668264,
0.0328594,
0.0024660914,
0.00839813,
-0.022412468,
-0.009255616,
-0.019349081,
-0.025580585,
-0.023996526,
0.030817144,
-0.02507002,
-0.023302684,
-0.02412744,
-0.022896849,
-0.002495547,
-0.021914994,
0.019859646,
0.008954514,
-0.00054533844,
0.002737738,
-0.006038406,
-0.16453265,
0.020435667,
0.011703707,
-0.0024824557,
0.017058088,
0.009497807,
-0.019388355,
-0.0012011355,
-0.001742792,
0.01735919,
0.0022549927,
-0.01831486,
-0.034325637,
0.0018867973,
0.0073900926,
0.0051350994,
0.013732873,
0.030529132,
0.019676367,
-0.019362172,
0.021941178,
-0.022674296,
0.015186018,
-0.026510075,
-0.012796839,
0.008620683,
-0.0018197038,
0.0099036405,
0.004094334,
-0.006964622,
-0.033383057,
0.018917065,
0.031131336,
0.021168785,
0.007213359,
-0.004451074,
-0.022307737,
-0.035975154,
-0.013091395,
0.02345978,
0.042285204,
0.03144553,
-0.013876879,
0.0063493266,
-0.015539486,
0.032414295,
0.02309322,
0.0099036405,
0.01821013,
0.0067617055,
0.017490104,
-0.010342202,
0.0024742736,
0.029586552,
0.010106557,
0.0046376265,
-0.010355294,
0.019414539,
0.0036001336,
0.009072336,
-0.031288434,
-0.028015586,
0.04854289,
-0.0024922744,
0.023773974,
-0.05084698,
-0.015172927,
0.0027639207,
-0.016272604,
0.009373439,
-0.026248246,
-0.02393107,
0.02187572,
-0.007612646,
0.019087253,
0.0134710455,
-0.0028539242,
-0.004866726,
0.004261249,
-0.0016732439,
-0.008875966,
-0.0023204498,
-0.029062897,
-0.02543658,
-0.019506179,
0.008515952,
0.0073311813,
0.024048893,
0.0043528886,
0.004464166,
0.015657308,
-0.021234242,
-0.0016969721,
-0.00914434,
0.001515329,
0.0031288434,
-0.015186018,
-0.006814071,
0.02017384,
0.0145314485,
0.017123545,
0.0018360681,
-0.0025315485,
0.013228854,
0.014125615,
-0.0006185684,
-0.040609505,
-0.021325883,
0.050244775,
-0.017058088,
-0.0042514303,
-0.0072329957,
-0.0011193142,
0.015500211,
0.025567494,
0.017437737,
0.029926928,
-0.012679016,
0.0120899035,
-0.026863541,
0.058073428,
-0.0015783313,
-0.0039437828,
0.009838183,
0.017869754,
-0.034954023,
-0.12085976,
-0.05707848,
0.0007445731,
0.028748702,
0.00058788544,
0.019754915,
0.009497807,
0.030843327,
-0.0112193255,
0.01361505,
-0.031471714,
-0.0040059667,
-0.0036623178,
-0.013163397,
0.008352309,
0.014518357,
0.02345978,
0.008188668,
-0.03136698,
0.03228338,
-0.0014343259,
-0.033932894,
0.0011904987,
-0.010970589,
0.009661449,
-0.005717667,
-0.012044083,
0.020946233,
-0.0052889236,
0.014649271,
0.009137793,
0.00094421685,
0.0145314485,
0.011500791,
-0.01022438,
-0.017895937,
-0.005907492,
-0.03576569,
0.046893377,
-0.0067747966,
0.014662363,
0.024310721,
0.013562685,
-0.0074162753,
-0.022870667,
-0.010813492,
-0.0134710455,
-0.02534494,
0.008129756,
-0.011703707,
-0.025410397,
-0.016573707,
-0.0154871205,
0.009864366,
0.02618279,
-0.031105153,
0.030345853,
0.02533185,
0.013052121,
-0.01699263,
0.036551174,
0.011742981,
-0.008908695,
-0.009582901,
0.027544295,
-0.021626985,
-0.013444862,
-0.024075076,
0.021443704,
-0.015906045,
0.002811377,
0.0006259323,
-0.0047718133,
-0.0039241454,
-0.035922788,
0.0088236,
-0.023250317,
0.0029521096,
-0.0054787486,
-0.023996526,
0.007723923,
-0.011396059,
0.0168879,
0.0024546366,
0.017699566,
-0.004215429,
0.010381476,
0.010093465,
0.003740866,
-0.009301436,
-0.009052699,
0.023538329,
0.014479083,
-0.010859312,
-0.0045819883,
-0.002510275,
0.013968518,
-0.007291907,
0.022962306,
-0.0062216856,
-0.010584393,
0.00252173,
-0.041028433,
0.013693599,
-0.010008371,
0.010145831,
-0.012024446,
-0.015552577,
-0.018642146,
-0.020304753,
0.01737228,
0.00090330624,
-0.006984259,
0.013863787,
0.013693599,
-0.010257108,
-0.017437737,
-0.021561528,
0.011422242,
-0.025174752,
0.015801314,
0.033906713,
0.008280307,
0.012142269,
0.0055671157,
-0.007357364,
0.009700724,
-0.009654904,
0.0002591687,
0.00929489,
-0.025030747,
-0.027151553,
0.015002739,
-0.04042623,
-0.024611821,
0.013719781,
0.0007826199,
0.00069588947,
-0.0035837693,
0.024664188,
0.042285204,
0.014282712,
-0.0023908159,
-0.05105644,
-0.009150885,
0.0047259936,
-0.02309322,
-0.012004809,
-0.04212811,
0.012980118,
0.00023359958,
-0.02092005,
0.024624914,
0.02609115,
0.0008202577,
-0.014937282,
-0.012803384,
0.010538572,
-0.008070845,
-0.006918802,
-0.033095047,
-0.01177571,
-0.0022435377,
0.01568349,
0.008195213,
0.0076061003,
0.01135024,
-0.0054722033,
-0.018995615,
-0.006486786,
0.0008722142,
-0.010905132,
-0.010787309,
0.020514216,
0.0022157186,
0.02196736,
0.0017166091,
0.0020406211,
-0.00050647336,
0.008882511,
-0.012338639,
0.029298542,
0.00028391962,
0.0013696871,
-0.03610607,
0.009956006,
0.033671066,
-0.0002822832,
0.016848626,
0.02533185,
0.017516287,
-0.008895603,
-0.007867929,
0.021247333,
0.0008141211,
0.021456797,
0.018000668,
0.008784326,
-0.022648113,
0.0019326172,
-0.0015832406,
0.0003428309,
-0.012993209,
0.0024922744,
-0.01606314,
-0.02412744,
-0.015892953,
0.0088432375,
0.0011667706,
-0.03859343,
-0.0022124457,
0.0022353556,
-0.002680463,
-0.0014899643,
-0.010014917,
0.016010776,
-0.016324969,
0.008666503,
0.0053020148,
0.011991718,
0.008581409,
0.0099036405,
0.012004809,
0.010754581,
-0.017725749,
0.015434754,
0.005691484,
0.02365615,
0.02139134,
-0.012679016,
0.015028921,
-0.023983436,
0.041316442,
-0.011841167,
-0.04309687,
-0.028879616,
-0.010407659,
-0.010414205,
0.0064344206,
0.01661298,
-0.01839341,
0.07048407,
0.021561528,
-0.014426718,
-0.017136635,
-0.008339219,
0.03584424,
-0.0021486252,
0.014963464,
-0.007638829,
-0.02825123,
0.014819459,
-0.030110208,
0.018458867,
-0.043201603,
-0.022739753,
0.021181878,
0.0060482244,
0.0055311145,
-0.003937237,
-0.026313704,
-0.0118346205,
-0.024755828,
0.0066078817,
0.012220817,
-0.041264076,
0.0032106645,
0.043515798,
0.014112524,
0.023040855,
-0.021548435,
-0.031576443,
-0.00044756205,
-0.026352977,
0.004280886,
0.021286609,
-0.0034986753,
-0.006643883,
-0.0054852944,
0.026915908,
0.00389469,
-0.0074359123,
0.0017935211,
-0.021129511,
-0.029272359,
-0.012751019,
-0.0066340645,
-0.02440236,
0.01492419,
-0.026575532
] |
Metabolic pathway reprogramming is a hallmark of cancer cell growth and survival and supports the anabolic and energetic demands of these rapidly dividing cells. The underlying regulators of the tumor metabolic program are not completely understood; however, these factors have potential as cancer therapy targets. Here, we determined that upregulation of the oncogenic transcriptional coregulator steroid receptor coactivator 2 (SRC-2), also known as NCOA2, drives glutamine-dependent de novo lipogenesis, which supports tumor cell survival and eventual metastasis. SRC-2 was highly elevated in a variety of tumors, especially in prostate cancer, in which SRC | [
-0.0012207053,
-0.02444101,
0.0048189275,
-0.027104367,
-0.019813763,
0.024588974,
-0.023593577,
0.00065406936,
-0.02444101,
-0.0057235276,
0.0393585,
0.007115737,
0.010687057,
-0.0019487569,
-0.010175907,
-0.011245285,
0.04051531,
-0.01927571,
-0.024427557,
0.005982465,
-0.026189677,
0.018872172,
-0.015294126,
-0.013632891,
0.0233111,
0.020123143,
0.011023339,
-0.041376192,
0.008797149,
-0.017002441,
0.008003523,
-0.0011467232,
0.0052291923,
0.012381921,
-0.0031190198,
-0.009590776,
0.012307938,
-0.01419112,
-0.00994051,
-0.0062817563,
0.0013669882,
0.006100164,
-0.0076605147,
0.0052964487,
-0.0144735975,
-0.0069475956,
0.02154898,
-0.014957844,
-0.003507426,
0.02838224,
-0.0001378758,
0.01760775,
-0.010565995,
-0.015240321,
-0.012287761,
0.017379077,
-0.014742623,
0.022530925,
0.014150766,
-0.015025101,
0.0032484885,
-0.0191681,
-0.026485607,
0.01720421,
0.009415909,
0.026377996,
0.014904039,
0.019396773,
0.0068803392,
-0.000886945,
0.023459064,
0.028543655,
-0.03118011,
-0.008359982,
0.0006511269,
-0.020513231,
-0.038578324,
-0.0006776092,
0.006480163,
0.013088114,
0.021522077,
-0.014365987,
0.002414508,
0.015657311,
-0.0064868885,
-0.014339084,
-0.006782817,
-0.007223347,
0.011669002,
-0.014581207,
0.020271108,
0.031906478,
0.039277792,
0.021226149,
-0.022625083,
0.012415549,
0.005252732,
0.028113214,
-0.00053763157,
-0.028247727,
-0.020674646,
0.01409696,
-0.0012232275,
-0.023808798,
-0.019006684,
0.0040051243,
-0.0020176948,
0.0062145,
0.02321694,
0.010505464,
-0.012671123,
0.038201686,
-0.003430081,
-0.0201904,
0.035780452,
-0.0055452976,
0.03906257,
0.013841386,
-0.0057773325,
-0.020271108,
0.01967925,
0.012698025,
0.0170966,
-0.00984635,
0.016424036,
-0.0049803434,
-0.018374473,
0.009516793,
-0.0181189,
-0.0004888706,
0.025853395,
0.006823171,
0.00603627,
0.029001,
-0.010283518,
0.0100817485,
0.004906361,
-0.00028520956,
-0.01667961,
-0.028866487,
0.0054713157,
0.035511427,
-0.017002441,
-0.0048256535,
-0.013303334,
0.018831817,
0.0026801713,
0.0029105246,
0.018979782,
-0.009288122,
0.011998558,
-0.026593218,
0.012213779,
-0.02705056,
0.0146350125,
0.02072845,
0.022571279,
0.037798148,
-0.017567396,
-0.012442451,
0.022423314,
-0.0023321188,
0.0007974098,
-0.0044153887,
-0.0010315465,
0.016733415,
0.022530925,
0.0099068815,
-0.023136234,
-0.0073713115,
0.025261538,
0.02808631,
-0.01678722,
0.033009488,
-0.0086760875,
0.034758154,
-0.02765587,
0.01885872,
-0.024696585,
-0.0051518474,
0.009241042,
0.0052796346,
0.017782617,
0.01460811,
-0.011911125,
-0.0004069018,
0.020459425,
-0.0071022855,
-0.008689539,
-0.013962448,
-0.011285639,
0.029673565,
0.004889547,
-0.012731654,
-0.6288751,
-0.011931302,
0.023607029,
-0.025422955,
0.0022312342,
0.017769165,
0.0071829935,
-0.0037125584,
-0.027386844,
0.008958565,
-0.004563353,
0.0021891987,
0.011709355,
-0.009503342,
-0.012879618,
-0.033090193,
-0.026983304,
0.011568117,
0.014029704,
-0.0022934463,
-0.022221545,
-0.008689539,
-0.009651307,
0.012523158,
0.009368829,
0.03478506,
0.0072973296,
-0.016114656,
0.015912887,
0.027951797,
-0.02456207,
0.011278913,
-0.001298891,
-0.01289307,
0.051034227,
0.0044624684,
-0.005827775,
0.012381921,
0.015294126,
0.026445253,
0.0010441571,
-0.008662636,
0.009261219,
-0.004465831,
-0.042425394,
0.007694143,
0.0066012247,
0.015993593,
-0.01563041,
-0.016867928,
-0.005222467,
0.008064053,
-0.02060739,
-0.019221906,
0.032471433,
0.009375555,
0.025005965,
-0.034892667,
0.00065785256,
0.023257295,
0.0049164495,
0.024414107,
-0.0078084785,
-0.022275351,
-0.005444413,
0.006197686,
-0.031906478,
0.014581207,
-0.008824051,
0.030695863,
0.015065454,
0.0055890144,
0.0038235316,
0.009853076,
0.016074302,
0.037529122,
-0.008373434,
0.014150766,
0.00117867,
0.017742263,
0.014930941,
0.011635373,
-0.036103286,
-0.010848472,
0.0071829935,
-0.019033587,
-0.025086671,
0.0127114775,
0.02236951,
-0.0009945554,
0.023687737,
-0.0013871652,
-0.037044875,
-0.04360911,
0.004371672,
0.038255494,
-0.014379438,
0.029270025,
0.023324551,
-0.051679887,
-0.0011660594,
-0.022853756,
0.017742263,
-0.0022396413,
0.027158171,
-0.0045532645,
-0.04153761,
0.005790784,
0.015805276,
-0.031045597,
0.018266864,
0.007425117,
-0.015549701,
-0.010209535,
-0.020069337,
-0.011339445,
0.008884583,
0.010989711,
-0.013787581,
-0.031449135,
0.024481364,
-0.005316626,
0.0035713196,
-0.0050913165,
0.008245646,
0.009496617,
0.0068937903,
-0.007956443,
0.00813131,
-0.01584563,
0.0038470714,
-0.01337059,
0.014904039,
-0.025463307,
0.019477481,
-0.010922454,
0.013639617,
-0.0028331797,
-0.0035107888,
-0.046272468,
-0.02423924,
-0.019087393,
0.01635678,
0.0054175104,
-0.0069475956,
0.0035780454,
-0.01352528,
0.012254133,
0.02466968,
0.004358221,
-0.020782256,
-0.00250026,
-0.023257295,
0.009113255,
0.019598542,
-0.005962288,
-0.0067054722,
-0.015603506,
-0.014675367,
-0.006685295,
0.002263181,
0.0045129107,
-0.015173065,
-0.0039445935,
-0.014419792,
0.0066180388,
-0.006449898,
0.021737298,
-0.0040185754,
-0.024037471,
-0.01688138,
-0.023190038,
-0.00808423,
0.00086929015,
-0.0019437126,
0.003058489,
-0.022019776,
-0.0022900836,
0.008534849,
0.0011475639,
0.0048660072,
-0.0059521995,
-0.01822651,
-0.012402097,
0.013632891,
0.029485246,
0.028220825,
0.001121502,
0.015025101,
0.02206013,
-0.036506824,
0.028301531,
-0.011729532,
0.02206013,
0.014782977,
-0.045088753,
-0.015280675,
0.0077344966,
0.005696625,
0.028758876,
0.019840665,
-0.04021938,
0.019975178,
-0.007815205,
-0.0021707034,
0.0017099963,
0.00042077343,
-0.01015573,
-0.0025540653,
-0.0040992834,
0.0022951278,
0.01388174,
-0.0018815004,
0.0007028303,
0.003799992,
0.021589333,
0.0039614076,
0.0048424676,
-0.006019456,
-0.013713599,
-0.01165555,
-0.0074183913,
0.012993954,
-0.027292684,
0.006150606,
0.017997837,
-0.012462628,
0.015778374,
0.005693262,
0.0007541134,
0.0011223427,
-0.0008768565,
0.005272909,
0.00008181122,
0.017970935,
-0.0044591054,
0.015374834,
-0.007001401,
0.038282394,
-0.0015796869,
0.009039273,
0.003258577,
-0.0044153887,
0.016450938,
-0.00066247646,
-0.0020025622,
0.04702574,
0.007788302,
-0.03201409,
0.0019235357,
-0.003278754,
0.02290756,
-0.0029912326,
0.0029760997,
0.0019386684,
0.005538572,
0.0055284835,
0.024185434,
0.052137233,
0.023136234,
-0.0020328276,
-0.003229993,
-0.019665798,
-0.02060739,
-0.010599623,
0.020809159,
0.03481196,
0.0009550422,
0.007304055,
0.0018730933,
-0.022113934,
0.0050106086,
-0.0008243124,
-0.023916408,
0.0038268943,
0.017015893,
0.010754313,
0.0042237076,
0.017634653,
0.00958405,
0.032040995,
-0.006174146,
0.056280233,
0.015294126,
-0.008010249,
-0.011729532,
-0.0435284,
-0.00040248808,
0.013814484,
0.012092717,
0.02114544,
0.018791463,
-0.017553944,
0.0007301533,
-0.045519195,
-0.016706513,
0.0053435285,
-0.051330157,
0.030911084,
-0.012509707,
0.00947644,
0.0259072,
0.0012030505,
0.004045478,
0.042452298,
0.0028214098,
0.0035107888,
-0.01782297,
-0.03553833,
-0.037556026,
-0.002495216,
0.00062716677,
0.0050879535,
-0.031825773,
0.00489291,
-0.0032804355,
0.0048861844,
-0.00865591,
-0.0006002642,
0.017110052,
0.0059521995,
-0.01853589,
0.024091275,
-0.0028314984,
0.022813402,
0.020567035,
0.004153088,
0.010599623,
0.008218743,
0.022356058,
0.004375035,
-0.01865695,
0.011406701,
-0.034112494,
-0.023001721,
0.016491292,
-0.018724207,
-0.007936266,
0.013989351,
0.016101204,
-0.007115737,
-0.023566674,
-0.031987187,
-0.0023102604,
0.0035746826,
-0.012126345,
0.034569837,
0.04963529,
0.03255214,
-0.0054208734,
0.0067895427,
0.017136954,
0.010861924,
-0.011534489,
0.00013629948,
0.017042795,
-0.0040219384,
0.01750014,
0.0051249447,
-0.024723487,
0.030211616,
-0.0034435324,
-0.0010962809,
0.0052594575,
0.009819448,
0.0024481362,
0.020984026,
0.022625083,
0.018670402,
-0.014070058,
-0.0051215817,
0.01865695,
0.0051484844,
-0.03669514,
0.011063693,
-0.0109628085,
-0.026942952,
-0.0099001555,
0.010337323,
-0.013962448,
0.009678209,
-0.00901237,
-0.004062292,
0.0019790223,
-0.0085483,
-0.021912165,
0.021804554,
-0.014756074,
0.00031862763,
0.009590776,
0.0001835892,
-0.018508988,
-0.026337642,
0.0062851193,
0.015495895,
-0.03876664,
-0.02547676,
0.01842828,
-0.007478922,
0.016329877,
0.001490572,
-0.011016614,
-0.009994315,
0.017352175,
-0.0059858277,
-0.00636919,
-0.02465623,
-0.037744343,
-0.0028802592,
-0.020957123,
0.004529725,
-0.014890587,
-0.024844548,
0.022665437,
0.009617679,
-0.011581568,
-0.0025961006,
-0.0025187556,
-0.01097626,
0.008998918,
0.009927059,
0.0055688377,
0.00034532006,
0.004637335,
-0.010007766,
-0.010828295,
-0.027400294,
-0.0111242235,
-0.016827574,
-0.00911998,
0.02114544,
-0.0018529163,
-0.008386885,
-0.013558908,
0.015616957,
-0.0023018534,
-0.022692341,
0.0029206132,
0.008104407,
0.0100750225,
0.000180962,
0.002728932,
-0.011500861,
0.00022678048,
0.0036083108,
-0.004644061,
0.034435324,
0.0054511386,
0.012879618,
0.005118219,
-0.0142852785,
-0.0013400856,
-0.010982986,
0.010404579,
0.00022741102,
0.034004882,
-0.02040562,
-0.018831817,
-0.00427415,
-0.005017334,
0.0037428238,
0.0027255693,
0.0021236239,
-0.011325994,
-0.029404538,
0.0063153845,
0.011695904,
-0.018697305,
0.010761038,
-0.030964889,
-0.01573802,
0.0032905238,
0.01907394,
-0.00011055286,
0.0015426958,
0.010014492,
-0.02516738,
-0.030104006,
-0.014863685,
-0.029565955,
-0.01780952,
-0.004422114,
0.037744343,
0.014769525,
0.04288274,
0.00096344925,
0.011110772,
0.018145801,
0.016316425,
-0.0019622082,
-0.010888826,
0.014513951,
-0.029754272,
0.015401737,
-0.00859538,
-0.0040017613,
0.008191841,
-0.005313263,
0.016114656,
0.003951319,
-0.012650946,
-0.026028262,
0.011615196,
-0.020809159,
-0.046702906,
0.023553224,
-0.018293766,
-0.0023085792,
-0.029619759,
-0.029081708,
0.027198525,
0.016208814,
0.010989711,
0.0027171622,
0.02528844,
-0.017728811,
0.0022984906,
0.002508667,
-0.013195723,
-0.0018091997,
-0.021562431,
0.008494495,
-0.005599103,
0.011097321,
-0.022208095,
0.015186516,
-0.010814844,
-0.028597461,
0.024293045,
0.0088509545,
-0.009812722,
-0.027951797,
0.007001401,
-0.022880659,
0.011077144,
-0.008891309,
-0.015065454,
-0.037125584,
-0.021939067,
0.004677689,
-0.02881268,
0.017177308,
-0.0010441571,
-0.014796428,
0.049581487,
0.0106063485,
0.0134176705,
-0.025221184,
0.020378716,
0.0014636694,
0.008729893,
-0.029646661,
-0.006389367,
-0.016827574,
-0.022261899,
0.043340083,
0.0128863435,
-0.00087853795,
-0.002022739,
0.006244765,
-0.0044624684,
-0.020593937,
-0.017661555,
0.024736937,
-0.010458385,
0.015495895,
-0.008272548,
-0.031045597,
-0.027602063,
-0.0022766322,
-0.016491292,
-0.002752472,
0.0008028744,
-0.0135858115,
-0.02570543,
0.028678168,
0.001888226,
-0.0020445974,
-0.0023674285,
-0.01667961,
-0.0032047718,
-0.013007405,
-0.00484583,
-0.0054175104,
-0.015294126,
0.026337642,
0.014433243,
0.009570599,
0.013565634,
-0.002923976,
-0.012254133,
0.005888306,
0.004620521,
0.041268583,
-0.0064330837,
0.004563353,
0.018387925,
0.00012379399,
0.013653068,
0.022517474,
-0.00103575,
-0.028113214,
-0.045949634,
0.0002894131,
0.025947554,
0.0033140637,
-0.030884182,
0.004358221,
-0.004277513,
-0.011675727,
-0.029619759,
-0.017258016,
0.021629687,
-0.026889145,
0.0050106086,
-0.017755713,
0.026256934,
0.005770607,
-0.0034872491,
-0.013740501,
-0.02185836,
0.03739461,
-0.025046317,
0.026821889,
0.0132159,
0.012778734,
-0.007842107,
0.0253826,
-0.016074302,
-0.039869647,
0.017284919,
-0.0021622963,
-0.041887343,
-0.023297649,
-0.0032938868,
-0.0038840624,
0.016504744,
-0.0037663635,
0.017258016,
0.019975178,
0.0032114976,
-0.026539411,
-0.007223347,
0.00709556,
-0.0132159,
0.01802474,
0.02558437,
-0.003258577,
-0.010767764,
-0.0072906036,
-0.009052724,
0.021885263,
-0.016827574,
-0.0019437126,
0.0008734937,
0.022732694,
0.0014645101,
0.017042795,
0.006540694,
-0.007189719,
-0.007438568,
0.0055284835,
0.0027659233,
-0.016128106,
-0.02020385,
0.006806357,
0.0054040593,
-0.0058546774,
-0.033009488,
-0.014836783,
-0.01884527,
-0.011595019,
-0.037152488,
-0.009664758,
-0.033682052,
0.017325273,
0.00015794767,
-0.027010208,
-0.027131269,
0.013868289,
-0.033009488,
-0.009220865,
0.019181551,
0.014850234,
0.0107812155,
0.02819392,
-0.013491652,
0.00079068413,
-0.013962448,
0.014621561,
0.0040925574,
-0.021010928,
0.00484583,
0.0010979623,
0.020540133,
0.007458745,
-0.017540494,
-0.0055722003,
0.01440634,
-0.004213619,
-0.0045162733,
0.0038907882,
-0.020338364,
0.005363705,
-0.010720685,
0.016693061,
0.007916089,
0.02723888,
0.012563513,
-0.019961728,
0.006900516,
0.032283116,
0.012866167,
0.004354858,
0.0007032507,
0.0031257456,
0.01791713,
0.009281396,
0.0016234036,
-0.010330597,
0.0064431718,
0.0047113174,
0.0062245885,
0.032498337,
0.020567035,
0.0061775087,
0.01844173,
-0.029700467,
-0.010942631,
-0.0104314815,
-0.02705056,
-0.0061775087,
0.023674285,
-0.00076546293,
-0.029027902,
0.012496256,
0.014164217,
-0.011904399,
0.00007272108,
0.005141759,
-0.0042438847,
-0.024898354,
0.014850234,
-0.016424036,
-0.030184714,
-0.015159613,
0.0037260097,
-0.03335922,
0.014379438,
-0.015105808,
0.00515521,
-0.010323872,
-0.009684935,
-0.007330958,
0.0035713196,
0.015038552,
-0.01637023,
-0.025557468,
-0.01853589,
0.019033587,
0.19348347,
-0.020284558,
-0.019047039,
0.01842828,
0.008898034,
-0.011998558,
0.02672773,
0.0106063485,
-0.011426878,
0.0046642376,
0.0104314815,
0.0048021134,
-0.006634853,
-0.012422274,
0.01720421,
0.012543336,
-0.039304692,
-0.0041766283,
-0.014487049,
-0.019141197,
0.0036688417,
-0.0018007925,
0.009126706,
-0.01460811,
0.03287497,
0.0031207013,
-0.034865767,
-0.006308659,
0.025839943,
-0.00009100644,
-0.02238296,
0.033224706,
-0.0072569754,
-0.0011837143,
0.023338003,
0.018145801,
-0.0066045877,
-0.015213419,
0.00096428994,
-0.0054713157,
0.009947235,
0.0044254772,
-0.005370431,
-0.010337323,
-0.002577605,
0.01782297,
-0.02309588,
0.015576604,
-0.014742623,
-0.025974458,
-0.048532285,
0.00053090596,
0.010646703,
0.020661194,
0.0025456583,
0.011615196,
0.03169126,
-0.011151127,
-0.00006284279,
0.027575161,
-0.023499418,
0.0045129107,
-0.029027902,
0.021172343,
-0.008346531,
0.014930941,
-0.012207054,
0.007835382,
0.022194643,
-0.018159254,
0.00033165858,
0.018374473,
-0.004506185,
-0.0033342405,
0.005851315,
-0.016114656,
0.0074116653,
0.0018192881,
0.016666159,
0.028301531,
-0.0050375112,
0.0028415867,
-0.0135925375,
0.0077950275,
-0.0048660072,
-0.02298827,
0.009805997,
0.0057840585,
-0.018899074,
0.0029458343,
0.020809159,
0.005141759,
-0.0310725,
-0.0060026417,
0.0053065373,
0.0009903519,
0.0025355697,
0.015105808,
0.005424236,
-0.013975899,
-0.03968133,
0.082052924,
0.008891309,
0.020217301,
-0.0017066335,
0.0020883142,
0.0007015693,
0.0191681,
0.010323872,
0.0022161014,
0.01771536,
-0.017056247,
0.0026129147,
-0.0018394651,
-0.019517833,
0.009772369,
0.008454141,
-0.024615876,
0.019907922,
-0.027602063,
-0.030695863,
-0.024427557,
0.001802474,
0.023580126,
-0.004798751,
0.010639977,
-0.014392889,
-0.029646661,
-0.013814484,
-0.02953905,
-0.004660875,
-0.0022413225,
-0.0018815004,
0.0100817485,
0.00544105,
-0.025032867,
0.018697305,
-0.0052998117,
-0.0032888425,
0.031960286,
-0.01667961,
0.020593937,
-0.0039378675,
0.019020136,
0.007573081,
-0.029135512,
-0.009362103,
0.008171664,
-0.019100843,
-0.009483165,
-0.0027726488,
0.0035545055,
-0.001688138,
0.004156451,
0.0005082069,
-0.002137075,
-0.02185836,
-0.050899714,
0.0029475158,
0.015684213,
-0.04829016,
0.012395372,
0.012112894,
-0.02175075,
0.0000564324,
-0.010767764,
-0.16959397,
-0.009449537,
0.018872172,
-0.031987187,
0.011272188,
0.01844173,
0.011090595,
0.013437847,
-0.016114656,
0.0022934463,
0.032579046,
-0.0040017613,
-0.05498891,
-0.009160334,
0.015791824,
0.0019941549,
0.009859802,
0.03295568,
-0.0043649464,
0.0022009688,
0.015105808,
-0.031449135,
0.014621561,
-0.013498378,
-0.031852674,
0.00460707,
0.01958509,
-0.0074183913,
-0.000018416718,
0.0045700786,
-0.014836783,
0.0109493565,
0.008790423,
0.004314504,
0.018401377,
0.012260859,
-0.0075058243,
0.014365987,
-0.0045868927,
0.023660833,
0.011339445,
0.013444573,
0.025153928,
0.0067592775,
-0.036829654,
0.031987187,
0.017782617,
0.0019941549,
0.021925617,
0.010996437,
0.019033587,
0.009160334,
-0.007788302,
0.008978741,
0.03968133,
0.01853589,
0.02570543,
0.02249057,
0.003914328,
-0.021495175,
-0.01066688,
-0.017473236,
0.026485607,
0.009705111,
-0.005407422,
-0.043851234,
-0.010263341,
0.0067592775,
-0.038255494,
0.004465831,
-0.018091997,
0.018831817,
-0.00043023136,
-0.0031223826,
0.019356418,
-0.004139637,
-0.009072901,
0.01739253,
0.004257336,
0.02238296,
0.012751831,
-0.0052056527,
-0.022947915,
-0.01750014,
0.010263341,
0.0048996354,
0.03169126,
0.018051643,
0.007378037,
-0.0020530045,
0.020082789,
-0.019020136,
0.0107879415,
-0.017446334,
0.02267889,
0.011568117,
0.0055486606,
0.0077748504,
-0.000057430738,
-0.008776972,
0.01553625,
-0.012220505,
-0.034112494,
0.006096801,
0.035296205,
0.012866167,
-0.02423924,
0.0028415867,
0.023122782,
-0.0145005,
-0.011689179,
0.017567396,
-0.0030416748,
0.020459425,
-0.018616596,
0.028167019,
0.0074856477,
-0.021320308,
-0.012967052,
-0.023808798,
0.06133792,
0.015361383,
0.0076201605,
0.007855558,
0.00066878175,
-0.03378966,
-0.12967052,
-0.031637453,
0.00517875,
0.009947235,
-0.029619759,
0.03179887,
-0.013034308,
-0.0018730933,
-0.029458344,
0.028301531,
-0.034892667,
-0.018253412,
0.0071628164,
0.005313263,
-0.00035877136,
-0.0073376833,
0.024266142,
-0.012408823,
-0.012523158,
0.026848791,
-0.008232195,
-0.0006628968,
0.00035267623,
-0.011897674,
0.007889187,
0.024992513,
-0.016545096,
0.007599984,
-0.00020092877,
0.009987589,
-0.004546539,
-0.0068332595,
0.0362378,
-0.012254133,
-0.004637335,
-0.018199606,
0.010391128,
-0.03491957,
0.034838863,
-0.015724568,
-0.00073603826,
0.01533448,
0.011588293,
-0.004721406,
-0.004660875,
-0.019302614,
-0.024723487,
0.023593577,
0.029001,
-0.019746507,
-0.025086671,
-0.014070058,
-0.019114295,
-0.0160474,
0.01606085,
-0.020176947,
0.021777652,
0.0310725,
-0.009227591,
0.0029088433,
-0.001398935,
0.021078184,
-0.00401185,
-0.006211137,
0.014863685,
-0.024467912,
-0.0125366105,
-0.018078545,
0.02547676,
-0.006231314,
0.010384402,
-0.007741222,
-0.030399935,
-0.020876415,
-0.031045597,
-0.0008987149,
-0.0042438847,
-0.023163136,
0.027897993,
-0.038605228,
-0.006813083,
-0.017015893,
0.013948997,
-0.04000416,
0.00905945,
-0.010222986,
0.009180511,
-0.0037663635,
0.0033830015,
-0.02320349,
-0.0068937903,
0.037421513,
0.0059152083,
-0.030104006,
-0.0032215859,
-0.013975899,
0.0033661874,
0.01185732,
-0.0058782175,
0.025799591,
-0.009980864,
-0.016800672,
-0.060261816,
0.0008861043,
0.00088358216,
-0.006466712,
0.008212018,
-0.018939428,
0.016814124,
-0.02382225,
0.0010197766,
0.015549701,
-0.020445973,
0.012597141,
-0.0055890144,
-0.01154794,
-0.011426878,
-0.009200688,
0.02589375,
-0.020647744,
0.004502822,
0.01720421,
0.01989447,
-0.0038907882,
0.0121868765,
0.0057941466,
0.011144401,
0.00030959005,
-0.009765643,
0.035511427,
-0.0132428035,
-0.014002802,
0.0049568033,
-0.035134792,
-0.010061571,
0.005656271,
-0.03376276,
-0.010451659,
0.0066651185,
0.018145801,
0.017136954,
0.04207566,
-0.009072901,
-0.022921013,
0.0038605228,
0.0191681,
0.0017671643,
0.0045499015,
-0.026458705,
-0.0010307058,
0.004331318,
-0.014070058,
0.0111376755,
0.0040353895,
-0.0077479477,
-0.03376276,
-0.012294487,
-0.0069946754,
0.007956443,
-0.012200328,
-0.029673565,
-0.032605946,
0.014756074,
0.010444934,
0.038874254,
0.00090459984,
0.022880659,
-0.001584731,
-0.016491292,
0.0068702507,
0.02994259,
-0.041941147,
-0.04008487,
-0.00068475516,
0.013431122,
0.0038067175,
-0.0037663635,
-0.009637855,
-0.03699107,
0.004697866,
-0.008030425,
0.012059089,
0.00953697,
-0.009402458,
-0.011319268,
0.04503495,
0.01740598,
0.0024313221,
-0.0016494654,
0.013296609,
-0.0002088104,
0.005316626,
-0.0068736137,
0.014258376,
0.010323872,
0.0021723846,
0.009711837,
0.029162414,
-0.00588158,
0.012866167,
0.0135858115,
0.012879618,
-0.006577685,
0.0034183112,
0.011352896,
-0.0046911403,
0.008037151,
0.019047039,
-0.035080988,
-0.029700467,
-0.025745785,
0.014419792,
0.009348652,
0.01791713,
0.010128828,
-0.0036352135,
-0.021898713,
-0.0033577804,
-0.01563041,
-0.009099803,
-0.016612353,
-0.001361944,
0.0373139,
0.004045478,
0.0016133151,
-0.0026885783,
0.01771536,
0.012980503,
0.02363393,
-0.014796428,
0.019033587,
-0.021306857,
0.02434685,
0.0014788021,
-0.054881297,
-0.022853756,
-0.018724207,
-0.023028623,
0.004139637,
-0.005538572,
-0.02674118,
0.08479699,
0.013686696,
-0.034516033,
-0.012570239,
-0.013962448,
0.04495424,
0.011467231,
0.01915465,
-0.02516738,
0.0003566696,
0.010518915,
-0.04360911,
0.002626366,
-0.04775211,
-0.0036486648,
0.028866487,
0.013202449,
0.02454862,
0.02662012,
0.0031055685,
-0.011420152,
-0.019127747,
-0.006769366,
0.03179887,
-0.026768085,
-0.008783698,
0.04164522,
0.004580167,
-0.004307778,
-0.029270025,
-0.013532006,
0.0036688417,
-0.02819392,
0.004136274,
0.016921733,
0.001101325,
-0.014648464,
-0.009987589,
0.017701909,
0.038578324,
0.013895191,
-0.0076605147,
-0.020378716,
-0.026082067,
-0.0013056167,
-0.003367869,
-0.010323872,
-0.008790423,
-0.0022043316
] |
Synthetic peptides such as P60stc autophosphorylation site peptides and angiotensin are indiscriminately phosphorylated by protein tyrosine kinases. The observation has led to the general belief that protein tyrosine kinases are highly promiscuous, displaying littlein vitro site specificity. In recent years, evidence has been accumulating to indicate that such a belief requires close examination. Synthetic peptides showing high substrate activity for specific groups of protein tyrosine kinases have been obtained. Systematic modification of certain substrate peptides suggests that kinase substrate determinants reside with specific amino acid residues proximal to the target tyrosine | [
-0.04002137,
-0.035260074,
-0.020579398,
-0.02475876,
0.0020136333,
0.033355553,
-0.011579217,
-0.0009712721,
-0.03078974,
-0.003448636,
0.027456831,
-0.0014631079,
0.002676578,
0.004513316,
-0.0028369413,
-0.008133887,
0.039651047,
0.008907598,
-0.01897907,
-0.0051911394,
-0.010084698,
0.021372946,
-0.015923904,
-0.025433278,
-0.0013457285,
0.034651686,
-0.004271944,
-0.039889112,
-0.011089861,
-0.020764558,
0.010937764,
-0.0075651766,
-0.02285424,
-0.0036833945,
-0.0044670254,
0.0035544427,
-0.003577588,
-0.0054887207,
0.016426485,
0.013569705,
0.0061202543,
0.017444875,
-0.012300025,
-0.018291328,
0.00090266316,
-0.014429384,
0.003997508,
0.008418243,
-0.010534376,
0.03351426,
-0.0036172655,
-0.001486253,
0.0033163778,
0.0038354916,
-0.001518491,
-0.008272759,
0.008590179,
0.022259077,
0.00888776,
-0.01990488,
0.009344052,
-0.0017110922,
-0.018846814,
0.0017706085,
-0.010607119,
-0.0024153679,
-0.011308088,
0.024004888,
0.0010812118,
-0.00857034,
0.027456831,
0.008649695,
-0.012167767,
-0.01274309,
0.023184886,
-0.017590359,
-0.013404382,
-0.008464534,
-0.026782313,
0.00081834843,
0.0047646067,
-0.024309082,
-0.010514538,
0.026967475,
0.009026632,
0.0010431876,
-0.0023277467,
0.0016995196,
0.014323577,
0.013496963,
0.030842643,
0.023475854,
0.0070295306,
0.002625328,
-0.024679406,
0.010851797,
-0.0073734024,
0.023026176,
-0.011122926,
-0.021068752,
-0.011890024,
0.015606483,
0.010395505,
-0.025036503,
-0.033752326,
0.0060342867,
-0.0046488806,
-0.008907598,
0.010785667,
0.005353156,
-0.009740827,
0.041793633,
0.009145664,
-0.021981336,
0.020050364,
-0.00816034,
0.01095099,
0.0059879962,
-0.017947456,
-0.015368419,
0.007320499,
0.030022642,
0.021637464,
-0.009820181,
0.059410445,
0.009687923,
0.0044736383,
-0.0067121107,
-0.01323906,
0.008041306,
0.0063153356,
0.022814563,
-0.0022798032,
-0.00030398753,
-0.023687467,
0.008550501,
-0.019627137,
-0.030207803,
-0.012095025,
-0.04081492,
0.0044703316,
0.021888755,
-0.029916836,
0.016810033,
0.005128317,
0.016691001,
0.021227462,
0.008087597,
-0.0014887329,
0.014389707,
0.0060045286,
0.0047646067,
0.002286416,
-0.0021773027,
-0.022153271,
0.00011024972,
-0.006179771,
0.016426485,
-0.0155139025,
-0.010190505,
0.012551316,
0.0060475124,
0.014072287,
-0.011579217,
0.023727145,
0.005227511,
0.018767457,
0.017656488,
-0.009608568,
-0.009555665,
0.0034949265,
0.013741641,
-0.016452936,
0.011883412,
-0.00920518,
0.001730931,
0.017511003,
0.007294047,
-0.026438441,
-0.015540354,
0.023846177,
0.0060144477,
0.025420051,
0.023343597,
0.0018830281,
-0.00023992489,
0.020896817,
-0.022338433,
0.013635835,
-0.02593586,
-0.0007637919,
0.0056209792,
-0.009595342,
-0.030445868,
-0.6488065,
-0.029123286,
0.013834222,
-0.026372312,
0.0081934035,
0.043724604,
0.024216501,
0.002344279,
-0.016492615,
0.030657481,
0.0029543205,
0.00047447678,
-0.007975178,
-0.006361626,
-0.026848443,
-0.025658118,
-0.010554215,
-0.029943287,
0.017987134,
-0.00730066,
-0.004675332,
0.0059251734,
-0.0070890468,
0.02060585,
0.030604579,
-0.0012837325,
0.0025062955,
-0.027668444,
-0.010924539,
0.029625867,
-0.014773256,
0.026610376,
-0.022351658,
0.0050886394,
0.05946335,
0.00963502,
0.013027446,
0.022616176,
0.016400034,
0.047083966,
0.00013773466,
-0.01625455,
0.03240329,
0.012657123,
-0.015632935,
0.019018749,
0.008490985,
-0.0039346856,
-0.020023912,
-0.009754052,
0.006685659,
-0.0057003344,
-0.017828424,
-0.008867921,
-0.0063252547,
0.023859404,
0.010421957,
-0.018502941,
0.001940891,
0.016214872,
-0.011103087,
0.025367148,
0.022404563,
-0.01983875,
0.0061004157,
0.005908641,
-0.0061665447,
-0.0075850156,
-0.021029076,
0.0043413797,
0.03949234,
0.025909407,
-0.00884147,
-0.006057432,
-0.010236795,
0.027020378,
0.0069435625,
-0.0038619435,
-0.00730066,
0.0010555869,
-0.01675713,
0.02126714,
-0.026015215,
0.02053972,
0.014376481,
0.02545973,
-0.014310352,
0.011883412,
0.011083248,
0.00094730034,
0.014971644,
-0.01882036,
-0.021121657,
-0.02348908,
-0.036741365,
0.03840782,
0.00095308665,
0.007783403,
0.0170481,
-0.026623603,
-0.019534556,
-0.0025294407,
0.0013630874,
0.0052969465,
0.009621793,
-0.011327926,
-0.03523362,
-0.010408731,
0.051342685,
-0.014376481,
0.012326477,
-0.014521965,
0.0134440595,
-0.0109972805,
0.001089478,
-0.03224458,
0.0055879145,
0.0139135765,
0.014257449,
-0.026808765,
-0.004457106,
0.014879063,
0.012881962,
-0.00877534,
0.02260295,
0.029308448,
-0.0031031112,
-0.026041666,
0.009648246,
-0.01977262,
0.0003852024,
-0.030974902,
0.020936495,
-0.0061665447,
0.024560373,
0.009621793,
0.03589491,
0.00656332,
0.02069843,
-0.02545973,
-0.022893919,
-0.017709391,
0.0040041213,
0.004291783,
-0.0041661374,
-0.02269553,
-0.035418782,
0.00958873,
0.01285551,
-0.0014209505,
0.01185696,
0.0075056604,
-0.0020318187,
0.0026269811,
-0.0011804056,
-0.011513088,
-0.025287794,
-0.019124554,
0.00039305523,
-0.00016129317,
0.0032353695,
0.0068575945,
-0.02949361,
0.007955339,
-0.010223569,
-0.012227283,
-0.0010010303,
-0.001724318,
-0.021624237,
-0.047004614,
-0.00077867095,
-0.016558744,
-0.012795994,
0.034334265,
-0.0012605872,
0.022245852,
-0.0129547035,
-0.007214692,
0.0013680472,
0.0014763337,
-0.00714195,
-0.033143938,
-0.01777552,
0.0065335617,
0.024719084,
-0.007214692,
0.019481653,
0.0140458355,
0.008272759,
0.04494138,
0.0041595246,
-0.0022169803,
-0.020870365,
0.024295855,
-0.0024963762,
-0.027694896,
0.01999746,
0.025816826,
-0.017696165,
0.021055527,
0.022153271,
0.0027608927,
0.017934231,
-0.029969739,
-0.015527128,
-0.023819726,
-0.0038189595,
-0.019851975,
0.009767278,
0.018436812,
-0.007062595,
0.020843914,
-0.013781318,
-0.0065467875,
-0.0029625867,
0.003309765,
0.016651325,
-0.010759216,
0.0051448494,
-0.012286799,
0.016016485,
-0.0049960585,
0.0052771075,
-0.011526314,
-0.019865202,
0.026464893,
0.016228098,
0.0285678,
-0.0067220298,
-0.002005367,
-0.026888119,
0.010673247,
0.027880058,
0.021558108,
-0.004926623,
0.015117127,
0.00301549,
-0.020209074,
0.045364607,
0.021888755,
0.010435183,
-0.016082613,
-0.010058247,
0.0028501672,
0.012095025,
0.0301549,
0.022973273,
0.015408096,
-0.018132618,
0.019719718,
0.0057300925,
0.017735843,
-0.011023732,
0.016558744,
0.0003870623,
0.0011308087,
0.035789106,
0.018278101,
0.042163957,
0.011162603,
-0.017233262,
0.009846633,
0.002972506,
0.004414122,
-0.0062359804,
0.020936495,
0.014839385,
-0.006672433,
0.001846657,
0.0008671187,
-0.0151568055,
0.008358727,
0.018688103,
-0.02031488,
0.023303919,
-0.004169444,
0.009324213,
0.010435183,
0.016175194,
0.0063649323,
-0.033699423,
-0.041370407,
0.024520695,
0.024838116,
-0.00008095657,
-0.02485134,
-0.018225199,
-0.020394236,
0.013053898,
0.02069843,
-0.0053432365,
0.00054267247,
-0.002367424,
0.0022021013,
-0.024375211,
-0.025433278,
0.031477485,
-0.022444239,
0.020804236,
-0.028620703,
0.000492249,
0.0018532699,
-0.015751967,
0.005574689,
0.05523108,
-0.00078611047,
-0.012154541,
0.00030502077,
0.0015515556,
-0.02460005,
0.027536185,
-0.0084380815,
0.009132438,
-0.013232446,
-0.010712925,
-0.008834857,
0.00059226935,
0.0056672697,
0.015937129,
-0.021015849,
-0.0130671235,
-0.008510824,
0.0049034776,
0.006930337,
0.031133613,
0.023012951,
0.011837121,
0.013437447,
0.011222119,
0.023436178,
-0.0365033,
-0.02641199,
0.02777425,
-0.026041666,
-0.027218765,
-0.003997508,
-0.009562277,
-0.0045959773,
0.018344231,
0.008120662,
-0.009086148,
-0.0067352555,
-0.006341787,
-0.0070229177,
0.021214237,
-0.0006344267,
0.031477485,
0.0067286426,
0.002612102,
0.013424221,
0.031980064,
0.015302289,
0.009608568,
-0.038672335,
-0.0065732393,
0.0031064176,
-0.0026683118,
0.004549687,
-0.014826159,
-0.032562003,
-0.00285678,
0.024507469,
0.025155535,
0.010164053,
0.024652954,
0.00825292,
0.016452936,
0.0078098546,
-0.013543254,
-0.027456831,
0.011876798,
0.010335989,
-0.033117488,
-0.0043314607,
-0.0066393684,
-0.010144214,
-0.0062921904,
-0.033752326,
-0.00034407832,
-0.013020833,
0.0022814563,
-0.02206069,
-0.021280367,
-0.005792915,
-0.0038586368,
-0.019428749,
-0.0062624323,
-0.0076643704,
-0.006989853,
0.015474225,
0.00028394212,
-0.004268638,
-0.012941478,
-0.004675332,
0.02371392,
-0.032350387,
-0.019706491,
-0.0027112958,
0.015262612,
0.010395505,
-0.02317166,
-0.006080577,
0.008378565,
0.03510136,
-0.013258898,
0.0024500857,
-0.019957783,
-0.044676866,
-0.011195668,
0.019058427,
0.008259533,
-0.032456197,
0.001831778,
-0.011215507,
0.012042121,
-0.006024367,
0.014495513,
0.0032419825,
-0.0014358296,
0.0061566257,
0.011969379,
0.014455836,
-0.0015871,
0.001183712,
0.004523235,
-0.03795814,
0.0108848605,
-0.013212607,
-0.006159932,
0.0006683179,
-0.011453572,
0.0010374013,
-0.005776383,
0.0004802631,
0.008292598,
-0.0007022091,
-0.006771627,
0.013007607,
0.019031974,
-0.0012795994,
-0.0017408503,
0.014072287,
-0.0015093982,
-0.006530255,
-0.024586825,
-0.0018830281,
0.030842643,
-0.001096091,
-0.019785848,
0.014389707,
0.010679861,
-0.03631814,
-0.0058821896,
-0.01020373,
-0.030498773,
0.041132342,
0.001183712,
-0.02403134,
-0.00081876176,
-0.0022930289,
-0.029255543,
-0.016862938,
0.021148108,
-0.0009878045,
-0.014640998,
0.016214872,
-0.011394056,
0.010726151,
0.007862758,
-0.036423944,
-0.023594886,
0.012134702,
-0.03078974,
-0.00041702707,
-0.019362621,
-0.002316174,
-0.0026666587,
0.0076842094,
-0.017352294,
-0.029916836,
-0.014310352,
-0.020037137,
0.034413617,
0.04142331,
0.025631666,
-0.003405652,
0.015222934,
0.025129084,
-0.004724929,
-0.007842919,
-0.015474225,
0.0017838343,
-0.0340962,
0.021862302,
0.016042937,
-0.018066488,
0.015566806,
-0.0065038037,
0.004278557,
0.012319864,
-0.0075056604,
-0.015659386,
0.003527991,
-0.04425364,
-0.01285551,
0.03539233,
-0.020857139,
-0.0029129898,
-0.031503934,
-0.017630037,
0.02485134,
0.0018185521,
-0.0016995196,
-0.005885496,
0.029229091,
0.0119759925,
0.0036668624,
0.0025558923,
0.010461634,
-0.009965666,
-0.020843914,
0.0055581564,
0.015328741,
0.026491344,
0.0028237156,
-0.00014197106,
0.0030204498,
-0.015976807,
-0.007889209,
0.000560858,
-0.012716639,
0.022880692,
-0.014323577,
-0.007049369,
0.002706336,
-0.0059780767,
-0.013596157,
-0.028038766,
-0.003815653,
0.017246487,
-0.016558744,
-0.005098559,
-0.02403134,
-0.00408017,
0.045946546,
-0.005101865,
0.03224458,
-0.01698197,
0.0010167359,
0.03510136,
0.0020218992,
-0.0079685645,
-0.014839385,
0.003341176,
0.025327472,
0.027165862,
0.00444388,
-0.0038057335,
-0.015646162,
-0.010613731,
0.006996466,
-0.04364525,
-0.039651047,
0.018066488,
-0.027456831,
0.019124554,
-0.012260348,
0.00063194684,
-0.0072477567,
0.012604219,
-0.019217135,
0.010051633,
-0.002987385,
0.00094068743,
-0.041317504,
0.013728416,
0.0066393684,
0.026240055,
0.006636062,
-0.029281996,
-0.007135337,
0.00094068743,
-0.0033990392,
0.004681945,
0.004262025,
0.0146674495,
0.0051547685,
0.014720352,
0.014455836,
0.006371545,
0.015540354,
0.0006658381,
-0.0011027039,
0.039174918,
-0.009165502,
0.012035509,
0.017405197,
-0.004103315,
-0.022550046,
0.0002153331,
0.00608719,
-0.03184781,
-0.0026666587,
0.0033081116,
0.02634586,
0.03285297,
0.0027129492,
-0.013053898,
-0.009959052,
0.005938399,
-0.0018532699,
-0.011777605,
0.020328106,
-0.03901621,
-0.010481473,
-0.014654224,
0.02260295,
0.019666815,
0.021730045,
0.008371953,
0.009152276,
0.03729685,
-0.0046786387,
-0.0005397793,
0.029969739,
-0.0031477483,
-0.0067914655,
-0.0019375846,
-0.023806501,
0.00019549436,
0.02117456,
-0.012114864,
-0.013768093,
0.006520336,
0.0027179087,
0.027668444,
0.022034239,
-0.008828244,
0.036212333,
0.0048671067,
0.011189055,
0.016161969,
-0.000735687,
-0.008543888,
-0.03618588,
0.0030039174,
0.0135564795,
-0.018119391,
-0.012670348,
0.02015617,
-0.027562637,
-0.008986954,
0.00011107633,
-0.010097924,
-0.039254274,
-0.0017540762,
-0.01317293,
-0.010461634,
-0.010104537,
-0.012200831,
-0.01897907,
0.0057962216,
0.01380777,
-0.011208894,
-0.010792281,
0.012657123,
-0.004635655,
0.0022252465,
-0.0125976065,
0.006930337,
0.005812754,
-0.035418782,
-0.0023244403,
0.008166952,
-0.026557473,
0.04425364,
0.01911133,
-0.027562637,
-0.0105277635,
-0.009919375,
-0.053405914,
-0.007214692,
0.011962767,
-0.0034287972,
0.002777425,
0.008953889,
-0.0053696884,
0.0042091217,
-0.0021458915,
0.017272938,
0.00003709433,
-0.013305188,
0.024547147,
-0.0052837203,
0.0073138857,
0.0118635725,
-0.03094845,
-0.020592622,
0.042243313,
-0.015712291,
-0.011182442,
0.022801338,
-0.00841163,
0.027165862,
-0.014508739,
0.011407281,
-0.0010721191,
0.01739197,
0.030842643,
-0.037878785,
-0.004109928,
0.01618842,
0.0035742815,
-0.007479209,
0.009535826,
0.0048307357,
0.0014548417,
-0.00006339101,
-0.022867465,
-0.024481017,
-0.0029526674,
0.006513723,
0.035260074,
0.021346495,
-0.008576953,
0.010858409,
0.010408731,
-0.012068573,
-0.01659842,
-0.0057168663,
0.0007555257,
-0.020169396,
0.008795179,
0.021452302,
0.010693086,
-0.0011423813,
0.025089405,
-0.023026176,
0.0042752507,
0.020989398,
-0.023370048,
-0.012703413,
0.012769543,
0.020447139,
-0.014416158,
0.007551951,
-0.0102632465,
-0.017114228,
-0.011559378,
-0.009423407,
0.004113234,
-0.006196303,
-0.008431469,
0.007961952,
-0.005495334,
-0.005806141,
-0.014098738,
-0.018119391,
-0.058828507,
0.020711655,
0.17743778,
-0.008305823,
0.005389527,
0.023105532,
0.0062723514,
0.0039842823,
0.0058392053,
-0.007862758,
-0.018397134,
-0.009198567,
0.025314245,
-0.004543074,
-0.004635655,
-0.0073469505,
0.008352114,
0.0024401662,
-0.008147113,
0.0041892827,
-0.0022516982,
-0.003498233,
0.008259533,
-0.0026319409,
0.01831778,
0.010560828,
0.03793169,
-0.00060425524,
-0.0034287972,
-0.011823895,
0.023925534,
0.004076863,
-0.015434547,
0.0093043735,
0.018489715,
0.000672451,
0.007115498,
-0.0019227056,
-0.0139135765,
0.0071287244,
0.03203297,
-0.0067848526,
-0.015712291,
0.015341966,
0.021253914,
-0.022960046,
-0.014376481,
0.00041992022,
-0.009932601,
-0.0065600136,
-0.021650689,
0.015937129,
-0.035868462,
-0.01514358,
0.021227462,
-0.00011541606,
-0.007069208,
-0.016519066,
0.0034254908,
0.031794902,
0.002458352,
0.007928887,
-0.008504211,
-0.0065434813,
-0.024071017,
0.018040037,
-0.007875984,
0.028171025,
-0.005779689,
0.008490985,
0.0436188,
-0.018555844,
-0.0022847627,
-0.0037528302,
0.015103902,
-0.0034453296,
-0.005935093,
-0.012372768,
0.006067351,
0.018436812,
0.028303284,
-0.0020665366,
-0.00041826698,
0.014812933,
-0.019494878,
0.006930337,
-0.0077172737,
-0.012670348,
0.031371675,
0.008504211,
-0.013820996,
0.010851797,
-0.0039710565,
-0.024626503,
-0.0136887375,
-0.018939393,
-0.0044967835,
-0.025115857,
0.013139865,
-0.014680675,
-0.005756544,
-0.027403926,
-0.004787752,
0.07549306,
-0.020671979,
0.008338888,
-0.01688939,
-0.007975178,
-0.019931331,
0.013245672,
0.0043744445,
0.0053068656,
-0.0060210605,
-0.030049093,
0.006897272,
-0.012293412,
-0.0026931104,
0.028012315,
0.00011221293,
-0.025353923,
0.03457233,
-0.018132618,
-0.018780684,
-0.015646162,
-0.014588094,
0.022616176,
0.0032155307,
0.032112323,
-0.022589725,
-0.0049299295,
-0.010990668,
-0.009337438,
0.003987589,
0.01194954,
0.0049530747,
0.034069747,
-0.012557928,
-0.017881326,
0.0026352473,
-0.004427348,
-0.00025211746,
0.022338433,
0.015064225,
-0.008398404,
0.00072328775,
0.019574234,
0.0075122733,
0.0018714555,
0.0013961521,
0.017934231,
0.0031791597,
-0.0031791597,
0.01673068,
-0.02228553,
-0.0054887207,
-0.0072477567,
-0.005792915,
-0.015659386,
-0.008636469,
-0.01784165,
-0.012802606,
0.00338416,
-0.029334899,
-0.0053366236,
0.0124918,
-0.011526314,
-0.014627771,
0.002734441,
-0.16579905,
0.009086148,
0.009324213,
-0.03192716,
0.019375846,
0.016439712,
0.03510136,
0.0014655876,
-0.007637919,
-0.0051448494,
0.022841014,
-0.0325091,
-0.025472956,
-0.044359446,
0.037349753,
-0.006903885,
-0.009899536,
0.023581661,
-0.0033676277,
-0.0040338794,
0.011301475,
-0.020976173,
0.024242952,
-0.005905335,
0.0020863751,
0.022721982,
-0.010792281,
-0.0153816445,
-0.004754687,
0.0032337164,
0.0014217771,
0.02825038,
0.01242567,
0.006239287,
0.027351024,
0.009244857,
0.02269553,
0.016373582,
-0.014879063,
0.026967475,
0.040550407,
0.026292957,
0.012928252,
-0.009985505,
0.003994202,
0.025340697,
0.014429384,
-0.00051746075,
0.021690367,
-0.014059061,
0.022417787,
0.0016185114,
0.013675512,
0.022523595,
0.0015623015,
-0.0038288787,
-0.017021649,
0.006464126,
-0.0036172655,
-0.003802427,
-0.0075321123,
-0.011308088,
0.035603944,
-0.012657123,
-0.035180718,
-0.03713814,
-0.011883412,
-0.012736478,
-0.02110843,
-0.0058524315,
-0.01163212,
-0.010871635,
0.0072014662,
-0.01602971,
0.028197477,
0.018714555,
-0.015738742,
0.011645346,
-0.002316174,
-0.000059257934,
-0.015302289,
0.016016485,
-0.02713941,
-0.028885221,
-0.0072675953,
0.014416158,
0.035524588,
0.015355193,
-0.020394236,
-0.010739377,
0.009939214,
-0.032165226,
0.011830508,
0.0051779137,
-0.00068774336,
0.009297761,
-0.0007179148,
-0.002957627,
-0.0036867012,
0.009132438,
0.031874258,
-0.0017408503,
0.0053763012,
0.026398763,
0.013272124,
0.0108848605,
0.009707762,
0.0078363065,
0.010236795,
-0.013450673,
-0.019243587,
-0.017167132,
0.0011233692,
0.035656847,
-0.032482646,
0.035524588,
0.008695985,
-0.0022665772,
0.012114864,
-0.029176189,
0.047824614,
0.019574234,
0.021624237,
0.033355553,
-0.0038983144,
-0.047083966,
-0.14008802,
-0.010600505,
0.018873265,
-0.0020202461,
-0.014640998,
0.022669079,
0.013007607,
0.00804792,
-0.012405831,
0.022087142,
-0.034069747,
-0.0040338794,
-0.0057400116,
-0.02015617,
0.010646796,
0.0078561455,
0.03504846,
-0.018648425,
-0.049253006,
0.023145208,
-0.015553581,
0.010031795,
0.005786302,
0.006067351,
0.008332275,
0.01888649,
-0.019309716,
0.015738742,
0.02190198,
0.0044339607,
0.012723252,
-0.0064112227,
0.009086148,
0.00656332,
-0.0012448815,
0.0042752507,
-0.018516166,
-0.007241144,
0.02920264,
0.0012101638,
-0.022907143,
0.0021624237,
0.031821355,
0.01491874,
-0.01675713,
0.005439124,
-0.028832316,
-0.0056143664,
0.02650457,
-0.024309082,
-0.025248116,
-0.010494699,
-0.027853604,
-0.0039115404,
0.013073737,
-0.014469062,
-0.010494699,
0.012518251,
0.0037528302,
-0.008576953,
-0.009165502,
-0.013516801,
0.007366789,
-0.0040967017,
0.026240055,
-0.0023971824,
-0.013979706,
-0.03272071,
0.018291328,
-0.031636193,
0.0075056604,
0.006067351,
-0.011235345,
0.0059879962,
-0.029334899,
-0.022073915,
-0.013510189,
-0.009668084,
0.009000179,
-0.0140458355,
-0.02872651,
-0.0064442875,
0.004956381,
-0.02317166,
-0.0029394415,
0.0096614715,
0.021029076,
-0.026742635,
0.019640362,
-0.021465527,
-0.016360356,
0.018965846,
0.0064244485,
0.0058392053,
0.012200831,
0.014006157,
-0.00008018161,
-0.024639728,
0.025261343,
0.035286523,
-0.030657481,
-0.020579398,
-0.046951707,
0.005935093,
0.008067759,
-0.007928887,
0.011923089,
-0.0063583194,
-0.00043231944,
-0.0014953458,
0.023118757,
-0.01856907,
-0.03475749,
-0.0140458355,
-0.013940029,
-0.0058689634,
-0.022311982,
0.0058028344,
0.014389707,
-0.00070055586,
0.02285424,
0.022708757,
-0.01752423,
-0.014640998,
0.0017606891,
0.014852611,
0.0010522804,
0.0074329185,
-0.03790524,
0.013404382,
-0.010970829,
-0.007723887,
0.023039402,
-0.028541349,
-0.014535191,
-0.012319864,
-0.019124554,
-0.023277467,
-0.017722616,
0.03203297,
-0.009800343,
0.024573598,
-0.024613276,
-0.033038132,
0.005604447,
-0.015778419,
-0.00841163,
-0.007670983,
-0.025830053,
-0.002532747,
0.0078561455,
-0.00555485,
0.020685203,
0.027668444,
-0.011665185,
-0.0039644437,
-0.034969103,
-0.0030617805,
0.008431469,
0.00040855428,
-0.010210344,
-0.026888119,
-0.00618969,
0.005941706,
0.01095099,
0.008742276,
0.004483558,
0.013662286,
-0.05295624,
-0.0038421047,
0.017325843,
-0.010084698,
-0.01968004,
0.024864567,
0.008795179,
0.0050886394,
0.005164688,
-0.01181067,
-0.0070096916,
0.012247122,
0.0043777507,
0.0015755274,
0.018172296,
-0.0052473494,
-0.035127815,
0.005627592,
0.02936135,
-0.021439075,
0.001529237,
0.024507469,
0.004420735,
-0.0025724247,
0.0060045286,
0.008543888,
-0.01847649,
0.011354378,
-0.004791058,
0.0037263785,
-0.025644891,
-0.003028716,
0.0002808423,
0.046819452,
0.011804056,
-0.005389527,
0.010164053,
0.002271537,
-0.012022283,
0.024626503,
-0.044703316,
-0.03171555,
-0.02507618,
-0.04570848,
0.005660657,
0.008345501,
-0.0066393684,
-0.00714195,
0.008530662,
0.022457466,
-0.0086827595,
-0.007697435,
-0.0018284714,
0.010335989,
0.0023029482,
0.004523235,
0.019362621,
0.009013405,
0.0065401746,
0.0031427888,
0.018754233,
-0.02761554,
0.027959412,
-0.005511866,
0.007604854,
-0.012240509,
-0.024877792,
-0.01761681,
-0.02650457,
-0.02031488,
0.0061665447,
0.03063103,
0.0053333174,
0.06798078,
-0.0075122733,
0.0005658177,
0.0026385537,
-0.016175194,
0.025658118,
-0.0073403376,
0.021888755,
-0.04552332,
-0.015857775,
-0.0131993815,
-0.019825524,
0.02317166,
-0.046396226,
-0.0039446047,
0.005697028,
-0.0080809845,
-0.0023723838,
-0.012670348,
-0.016704228,
0.03171555,
-0.009377116,
0.0043446864,
0.013675512,
-0.027020378,
0.0004984486,
0.020830687,
0.0005120877,
0.006930337,
-0.04332783,
-0.011612282,
0.0028187558,
-0.03192716,
-0.0027526265,
0.009925988,
0.003534604,
0.00021409318,
-0.022245852,
0.0054622693,
0.012121476,
-0.008808405,
0.010501312,
-0.01596358,
-0.018291328,
0.005244043,
-0.005227511,
-0.021597786,
0.0078363065,
-0.002827022
] |
OBJECTIVE To determine the relative accuracy of clinic measurements and home blood pressure monitoring compared with ambulatory blood pressure monitoring as a reference standard for the diagnosis of hypertension. DESIGN Systematic review with meta-analysis with hierarchical summary receiver operating characteristic models. Methodological quality was appraised, including evidence of validation of blood pressure measurement equipment. DATA SOURCES Medline (from 1966), Embase (from 1980), Cochrane Database of Systematic Reviews, DARE, Medion, ARIF, and TRIP up to May 2010. Eligibility criteria for selecting studies Eligible studies examined diagnosis of hypertension in adults of all | [
-0.016465114,
0.014875919,
0.004933673,
-0.04791036,
0.015891962,
0.026065424,
0.0001029375,
0.00097126595,
-0.024385044,
-0.021154547,
-0.036551513,
0.0031604813,
-0.0018220395,
0.0147196045,
-0.027563436,
-0.0026801403,
0.042204883,
0.0064316858,
-0.005588239,
-0.029178685,
-0.024319913,
0.020555342,
-0.012413967,
0.007959007,
-0.013677509,
0.0109420065,
0.016999189,
-0.03717677,
0.0062590884,
-0.017702604,
0.00380365,
-0.009255114,
-0.0061613917,
-0.013377906,
-0.011821276,
-0.0100822775,
-0.021297835,
0.020451132,
0.021519281,
-0.0020402283,
0.009671953,
0.01178871,
-0.0051030135,
-0.008011112,
-0.0016966624,
-0.017103398,
0.034571532,
-0.017806813,
-0.029308947,
0.029569471,
0.001789474,
-0.0017373692,
-0.015409993,
0.008440977,
0.006734545,
-0.0040576607,
0.0012155072,
0.037228875,
0.002465208,
-0.024098467,
-0.016217617,
-0.012049234,
-0.02296519,
0.004614531,
-0.02233993,
-0.0126158735,
-0.0061158002,
0.0035203302,
0.022743743,
0.013885927,
0.031236824,
0.037671767,
0.0007127773,
0.015084338,
0.029595524,
-0.015032234,
-0.00025034725,
-0.018510228,
-0.0122316005,
0.010837797,
0.008603804,
-0.013189026,
-0.010225566,
0.0144721065,
0.018458124,
0.0069820425,
0.003377042,
0.009163931,
0.0013913609,
-0.011736605,
0.004529861,
0.010525169,
-0.004526604,
-0.011091808,
-0.0049401857,
0.0117105525,
0.009880371,
0.04389829,
-0.0024814908,
-0.0058683027,
0.0056859357,
-0.019956136,
-0.02508846,
-0.00897505,
-0.010453524,
0.0031002352,
-0.011319767,
-0.021076389,
0.00109013,
-0.02494517,
-0.010401419,
0.023903074,
-0.022365984,
-0.010101817,
0.0014214839,
0.002233993,
0.0006867249,
-0.017897997,
0.0024798627,
-0.0035333564,
0.000074849755,
0.014771709,
0.033425227,
0.0010339546,
0.009847806,
-0.00259547,
-0.04431513,
-0.039313067,
0.008115321,
-0.001659212,
-0.03076788,
0.0315234,
0.024919119,
0.008095782,
-0.013377906,
-0.0028592506,
-0.000039790964,
0.016816823,
-0.024489254,
-0.025075432,
0.0010005749,
0.015045259,
-0.0146675,
-0.023863995,
-0.01836694,
0.029595524,
0.025817925,
0.026000293,
0.012511664,
0.005171401,
-0.0015891963,
-0.024007285,
-0.004806667,
0.012492125,
-0.007516117,
-0.0015330208,
0.009704518,
0.024658594,
-0.005848763,
-0.017272739,
-0.017689578,
0.008792684,
0.0048978506,
0.007809206,
0.013254157,
0.0033444765,
-0.013195539,
-0.017663525,
-0.012681005,
-0.0021428096,
-0.02967368,
0.047623783,
-0.008167426,
0.0021835165,
0.013820797,
-0.008988077,
0.026365027,
0.018731674,
-0.025401087,
-0.03696835,
-0.036707826,
0.01374264,
0.015891962,
0.016100382,
0.011925485,
0.023824917,
0.020294817,
-0.008675449,
0.016230643,
-0.02481491,
0.022743743,
0.008186966,
-0.011645421,
-0.015774727,
-0.64484894,
-0.02021666,
-0.00853216,
-0.0077245357,
0.017220635,
0.027771855,
0.041866202,
0.0038003935,
0.011007138,
0.03180998,
0.0033249373,
0.020959154,
0.0032239843,
-0.017129451,
-0.024424123,
-0.021519281,
-0.010870363,
-0.01668656,
0.021662569,
-0.027563436,
-0.016061302,
0.030246833,
-0.020581394,
-0.0062232665,
-0.014888945,
0.004389829,
0.0047252537,
0.005770606,
-0.019148512,
0.016673535,
-0.0071774353,
0.019096408,
0.0138598755,
0.016491167,
0.049838237,
-0.047884308,
-0.019526271,
0.02124573,
-0.014433028,
0.007340263,
0.0025287108,
-0.01933088,
0.022730717,
0.00085565844,
-0.01271357,
0.018718647,
0.0075226296,
-0.013293236,
0.014367897,
-0.013599351,
-0.0042758496,
-0.017324844,
-0.010694509,
0.0046536094,
0.0026378052,
-0.0069038854,
0.017207608,
-0.0056208046,
-0.02508846,
-0.0018692595,
-0.0008145445,
0.010114843,
-0.012068773,
-0.011267662,
0.005236532,
0.027667645,
-0.007138357,
-0.0048587723,
-0.0076854574,
-0.012166469,
0.0061776745,
0.0041325614,
-0.016582351,
0.0069429637,
0.02847527,
0.00926814,
0.02881395,
0.0033509897,
-0.012446533,
-0.0032712042,
0.01307179,
0.013117382,
0.006636848,
0.0030595283,
0.033216808,
0.0027696956,
-0.004673149,
0.017350897,
0.0026117528,
-0.003069298,
0.003686414,
0.008414924,
-0.010362341,
-0.0070406604,
-0.022053353,
0.027563436,
-0.016855901,
-0.020073373,
0.0252578,
-0.010635891,
-0.03293023,
-0.008753605,
-0.0037906237,
0.0046829185,
-0.024697673,
0.004041378,
-0.025713716,
0.019995214,
0.03761966,
-0.019448115,
0.017585369,
-0.005627318,
-0.016829848,
0.0033102827,
0.00472851,
-0.027876064,
0.00087764015,
-0.0024098468,
0.022287825,
-0.012889423,
0.0121404175,
-0.010193001,
0.024554385,
-0.002411475,
-0.017559316,
0.00090450665,
0.0022600454,
-0.0013954316,
-0.0037613148,
-0.029022371,
-0.0053472547,
-0.035405207,
0.0034714818,
0.00008685829,
0.017728657,
-0.0018057568,
0.01580078,
-0.013377906,
-0.011443515,
-0.025687663,
-0.013273696,
-0.0074249334,
-0.002281213,
-0.0074640117,
-0.014797762,
-0.04032911,
0.00937235,
0.0025026584,
0.011658448,
0.0060408995,
-0.0144721065,
-0.02450228,
-0.014888945,
0.015370915,
-0.024046363,
-0.029178685,
-0.016751692,
-0.005835737,
-0.016269723,
-0.009984581,
0.013293236,
0.012368375,
-0.02128481,
0.006688953,
0.023173608,
-0.029829996,
-0.011339306,
0.015891962,
-0.020880997,
-0.04368987,
0.0369423,
0.009079261,
-0.019747717,
0.015084338,
-0.00798506,
0.0104209585,
-0.019617455,
-0.013925007,
-0.0076463786,
-0.011397923,
0.016113408,
0.01689498,
-0.018223653,
-0.012739622,
0.03556152,
-0.010844311,
0.0069169113,
-0.00676711,
-0.00021635702,
0.04389829,
-0.0035105606,
0.026221737,
-0.028214747,
0.0126289,
-0.007170922,
-0.016022224,
0.0013115754,
-0.019422062,
0.009548204,
0.024358992,
0.030924195,
-0.013599351,
0.018549306,
0.0080892695,
0.0021770035,
0.005627318,
0.013351854,
-0.0021183856,
0.0084735425,
0.01233581,
-0.012394428,
-0.0144721065,
0.0062949103,
-0.022834927,
0.008330254,
0.012759161,
0.007731049,
0.010401419,
-0.010193001,
0.01439395,
0.02004732,
0.00039506017,
0.039703853,
0.015514202,
-0.016256696,
-0.006773623,
0.016921032,
0.022483218,
0.02004732,
-0.000029003646,
-0.009437481,
0.0023268047,
0.013286723,
0.008681961,
0.016191565,
0.040589634,
0.018002206,
-0.0046601226,
-0.0035040474,
0.030351043,
0.014993154,
-0.008213018,
0.012752648,
-0.022209669,
0.012681005,
-0.00806973,
0.025544375,
0.013898954,
0.007529143,
-0.006936451,
-0.007490064,
-0.00676711,
-0.011756144,
-0.0009875487,
0.019109434,
0.0057152444,
0.0027013079,
-0.0042367713,
0.012622386,
0.029256843,
0.035379156,
0.04626906,
-0.0048555154,
-0.0103297755,
0.016386958,
-0.00084344635,
-0.0031474552,
-0.000598391,
-0.0028543659,
-0.004686175,
-0.010642405,
-0.011404437,
-0.0025319674,
-0.032252867,
0.01641301,
0.012036207,
0.0113262795,
-0.009281167,
0.020307845,
0.0020386002,
-0.023837943,
-0.0250103,
0.02738107,
0.029178685,
-0.011547725,
-0.015878936,
0.012381402,
-0.004894594,
-0.01775471,
0.027693698,
0.004008813,
-0.023499262,
0.010798719,
-0.030246833,
-0.0033542463,
0.0061158002,
0.02131086,
-0.0076463786,
-0.0062656016,
0.010271158,
-0.013351854,
-0.009906424,
-0.011293714,
-0.04595643,
0.011202531,
-0.010056226,
-0.00040869697,
-0.013833823,
0.0005784446,
-0.00981524,
0.023499262,
-0.0020011498,
0.0032321254,
0.01401619,
0.013898954,
0.023942154,
-0.020112451,
0.007887363,
0.032122605,
0.0004302716,
-0.025778847,
-0.021949144,
0.003904603,
-0.0035984875,
0.053615835,
0.005669653,
0.013885927,
0.023082424,
-0.022600455,
-0.007431446,
-0.023772813,
-0.0052169925,
0.022626506,
0.045461435,
-0.01662143,
0.00973057,
0.009196497,
0.016751692,
-0.006666157,
0.0065000732,
0.013872902,
-0.017793788,
0.0044582165,
0.025791874,
-0.019096408,
0.018757725,
0.037437294,
0.028631585,
0.02316058,
-0.022665586,
0.021636516,
0.0060571823,
0.019343905,
0.004871798,
-0.033842064,
0.029178685,
-0.018054312,
0.014237635,
-0.020477185,
0.02162349,
-0.008773144,
0.0023088937,
0.024059389,
-0.025075432,
0.021884013,
0.02624779,
-0.007398881,
0.013664482,
0.0034161205,
-0.013768692,
0.014862892,
0.008128348,
0.0029178686,
-0.00426608,
-0.002323548,
0.00343566,
0.003264691,
-0.020073373,
0.016360905,
-0.002155836,
-0.0071839485,
-0.022157565,
-0.010518655,
-0.00019885306,
-0.020125477,
-0.008310715,
0.045617748,
-0.02141507,
-0.040016484,
-0.020737708,
-0.043846186,
-0.006226523,
-0.019135486,
0.025817925,
0.00064805336,
-0.013078303,
-0.0187447,
0.018445097,
0.015266704,
0.0013140178,
0.014641447,
-0.0023365745,
-0.002838083,
0.017884972,
-0.03141919,
0.00973057,
0.0027045645,
-0.02309545,
-0.009079261,
0.002696423,
-0.01298712,
-0.005024856,
0.024254782,
0.018966146,
0.008454003,
-0.009535178,
0.03587415,
-0.0069234245,
0.0099455025,
0.00048685417,
0.017559316,
-0.0075682215,
-0.006754084,
-0.014172504,
0.0028999574,
-0.033763908,
-0.01057076,
-0.001220392,
0.02097218,
0.0153318355,
-0.045591693,
-0.009391889,
0.014263688,
-0.022379009,
0.027537383,
-0.016113408,
-0.0144721065,
0.009137878,
0.04061569,
-0.0050020604,
-0.008727553,
0.01935693,
0.03196629,
-0.0054058726,
-0.015097364,
0.023069398,
0.029361052,
0.005891098,
-0.03074183,
0.033972327,
0.006936451,
-0.016764717,
-0.019825874,
-0.006552178,
0.0044744993,
0.039365172,
0.0074509857,
-0.012622386,
-0.02343413,
-0.014680526,
-0.008558213,
-0.0026899101,
-0.005272354,
-0.0036310528,
-0.00041378534,
0.010792205,
0.0045428867,
0.012948042,
0.023785839,
-0.024345966,
0.009984581,
-0.009157417,
-0.028318956,
0.010368854,
0.009313732,
0.004809924,
-0.014498159,
0.003950195,
-0.023798864,
-0.021610463,
-0.019956136,
0.0012089941,
0.011072269,
0.021675594,
-0.00324678,
0.004301902,
0.0071123047,
0.018445097,
-0.004568939,
0.012596334,
-0.006151622,
-0.014276714,
-0.0019636995,
0.018562334,
-0.007802693,
-0.017689578,
-0.011658448,
-0.006369811,
0.0147196045,
0.008076243,
0.004608018,
-0.0028364547,
-0.016647482,
-0.0353531,
0.01206226,
-0.0037645714,
0.011723579,
0.029569471,
-0.043220926,
-0.022431115,
0.017025242,
0.014341844,
0.0062590884,
-0.02532293,
0.001901825,
-0.039677802,
0.015449071,
-0.004849002,
0.031106561,
-0.030351043,
0.0025466217,
-0.038244918,
0.020203633,
0.03074183,
-0.003026963,
0.0022844695,
-0.011593317,
0.0042921323,
-0.019995214,
-0.00009016572,
-0.007822232,
0.016725639,
-0.0069755292,
-0.015019207,
0.011769171,
-0.007731049,
-0.016608404,
0.005243045,
-0.0072490796,
0.04098042,
0.0048424895,
0.018002206,
-0.016569324,
-0.007861311,
-0.0022014275,
-0.019487193,
0.021870987,
-0.0023968206,
0.030793933,
0.02515359,
-0.024489254,
-0.00398276,
-0.0026508314,
-0.013228104,
0.008870841,
0.024958197,
0.014524211,
-0.014980128,
-0.002743643,
0.0012391171,
0.03076788,
-0.025648585,
-0.025101485,
0.024867013,
0.015032234,
-0.025466219,
-0.0005466933,
-0.0011275803,
-0.019005224,
0.030116571,
-0.027172651,
-0.014328819,
0.0002843375,
-0.01029721,
-0.0035463825,
0.040589634,
-0.031445242,
-0.0015094108,
-0.0006089748,
-0.03347733,
-0.005236532,
0.0048262067,
-0.029908152,
-0.004083713,
0.010909441,
0.021167573,
-0.009691492,
-0.010166948,
0.020542316,
0.019252721,
0.00019559651,
0.0015419762,
-0.025752794,
0.037697818,
0.0011194389,
-0.010876876,
0.016178539,
-0.013267184,
0.011730092,
-0.0036766445,
-0.015292757,
-0.026990283,
-0.002618266,
0.008401898,
0.01901825,
0.029335,
-0.026534367,
0.008167426,
-0.017155504,
-0.0089945905,
-0.01048609,
-0.006574974,
-0.01565749,
-0.034832057,
-0.028709741,
0.008734066,
-0.020086398,
0.033842064,
-0.0023561136,
0.0039534513,
0.007288158,
0.01206226,
-0.022418087,
0.03183603,
0.01445908,
0.00491739,
-0.017963128,
0.014029216,
-0.018562334,
-0.022326905,
0.009912937,
0.00015092072,
-0.03360759,
-0.03501442,
0.0011161824,
0.011821276,
-0.007477038,
-0.009808728,
-0.0034942778,
0.005591496,
-0.0036896707,
-0.017520238,
-0.012921989,
0.013377906,
-0.013416985,
0.0027208473,
0.03194024,
-0.025765821,
0.020346923,
-0.00195393,
-0.01094852,
0.009111826,
-0.024176626,
-0.014276714,
-0.0025319674,
0.040250953,
-0.027745804,
-0.005330972,
-0.02210546,
0.022561377,
-0.008004599,
0.021076389,
-0.0044223946,
-0.013925007,
-0.004888081,
-0.014237635,
0.0063014235,
-0.006272115,
-0.019161537,
0.011645421,
-0.00014685004,
-0.002162349,
-0.028136589,
-0.011886407,
-0.022014275,
0.040928315,
0.026508315,
0.013755666,
-0.023225712,
0.006754084,
-0.04540933,
-0.022079406,
0.00640889,
0.030272886,
0.010648917,
0.013026198,
0.033164702,
0.026013318,
-0.004673149,
0.004875055,
-0.013495142,
-0.01901825,
0.0033672724,
0.0066401046,
0.0129545545,
-0.004770845,
-0.04890035,
-0.013755666,
0.0039371685,
-0.022040328,
-0.0013856619,
0.027719751,
0.013136921,
0.013625404,
0.015136443,
0.010603325,
0.0020711655,
-0.021597438,
-0.020034293,
-0.024749778,
0.0050378824,
0.009222548,
0.013690535,
-0.012290219,
-0.027771855,
0.035170738,
0.002334946,
-0.0121404175,
-0.037880186,
-0.04283014,
0.0045787087,
-0.011528186,
-0.008538674,
0.0055231084,
-0.029517366,
0.0043409807,
-0.0070471736,
0.008128348,
-0.013625404,
0.01439395,
-0.0055589303,
-0.012804753,
-0.013013173,
-0.021063363,
-0.019930083,
-0.007516117,
0.019474167,
-0.010492603,
0.005076961,
-0.029439209,
-0.03186208,
-0.015136443,
0.025479244,
0.015149469,
-0.00861683,
0.004871798,
0.001101528,
-0.018392993,
0.004829463,
-0.015253679,
0.0007518559,
-0.017181557,
0.015709596,
-0.0032500366,
0.0041553574,
0.014263688,
-0.0017341127,
-0.022522297,
-0.012440019,
0.015019207,
0.18820252,
-0.013026198,
-0.0076854574,
0.025127538,
-0.017468132,
-0.0014638191,
0.019226668,
0.026638577,
0.013625404,
0.020907048,
0.014980128,
-0.0076659177,
-0.015722621,
0.004184666,
0.016660508,
-0.03944333,
-0.0027615542,
-0.020854944,
0.027850013,
-0.00014654473,
-0.011515159,
-0.0041976925,
0.006428429,
-0.018067338,
0.047780097,
0.024463201,
0.010968059,
-0.0018774009,
0.050958488,
0.00806973,
-0.025752794,
-0.010720561,
0.019265749,
0.025687663,
0.00096149626,
0.005265841,
0.0153318355,
0.006333989,
-0.003329822,
0.015279731,
-0.0096459,
-0.00781572,
-0.01363843,
-0.01158029,
0.021636516,
0.019799821,
0.016855901,
-0.023460183,
-0.012746136,
0.004591735,
-0.027016336,
0.004148844,
-0.0065391515,
0.0026117528,
-0.021597438,
-0.01767655,
0.03128893,
0.0016689817,
0.000118049924,
-0.009756623,
-0.002618266,
-0.00035598158,
-0.0138598755,
0.015084338,
-0.03194024,
0.003406351,
-0.016868927,
-0.004767589,
-0.013846849,
-0.0027810934,
0.013215079,
-0.01748116,
-0.012303244,
-0.0010469807,
-0.021375991,
-0.027797908,
0.013964085,
0.04311672,
-0.0011691013,
0.015175521,
0.0067996755,
-0.005291893,
-0.026091475,
0.00464384,
-0.009554717,
-0.02347321,
0.0011178107,
0.02042508,
-0.0067866496,
-0.009912937,
0.009417942,
-0.0019360188,
-0.012935015,
-0.02288703,
0.0039371685,
-0.0051225526,
-0.016126433,
-0.01439395,
-0.0036896707,
-0.015787752,
0.0003903789,
0.09045392,
0.022352956,
0.0030839525,
-0.004585222,
-0.025713716,
-0.012843831,
0.019917058,
0.004969495,
0.016321827,
0.0031246594,
-0.035274945,
0.0028576222,
-0.021193625,
-0.00086787046,
0.04204857,
0.01880983,
-0.039078597,
-0.00012466479,
-0.019552324,
0.010557734,
0.0036994405,
0.0067019793,
0.037020456,
0.009678465,
-0.0043344675,
0.0053537674,
0.016582351,
-0.013182513,
-0.017416028,
0.0070471736,
-0.011534699,
0.023668602,
-0.014524211,
0.0046177874,
-0.009671953,
-0.023877023,
-0.018171547,
-0.015436046,
0.0014556777,
-0.00741842,
-0.010831284,
0.0036408226,
0.00537005,
0.024007285,
0.009313732,
0.01994311,
0.016842876,
-0.009880371,
0.010518655,
0.0020532545,
-0.0042042057,
-0.0044223946,
-0.036317043,
0.010544708,
-0.015019207,
-0.008186966,
-0.012153443,
0.022847952,
0.000043276494,
-0.019656533,
0.010225566,
0.020372974,
-0.00926814,
0.009678465,
0.018614437,
-0.16319221,
0.01880983,
0.027355017,
-0.021258757,
0.0035398696,
-0.0124790985,
0.02015153,
0.0044191377,
-0.015475124,
-0.014446055,
0.019448115,
0.002694795,
-0.0053244587,
-0.03180998,
0.017350897,
-0.0025010302,
-0.011834301,
0.02456741,
0.019448115,
-0.0020760505,
-0.0011756144,
0.0034682255,
0.015136443,
-0.011463054,
0.021193625,
0.005288637,
-0.021610463,
0.037697818,
-0.0116193695,
-0.0074640117,
-0.009124852,
0.0029813712,
0.025843978,
0.018002206,
-0.0070406604,
0.014263688,
-0.004269337,
-0.0032207277,
-0.010551221,
-0.00008492471,
0.013599351,
0.029361052,
-0.00519094,
0.010583786,
-0.00084100396,
0.03347733,
0.02004732,
-0.0298821,
0.018015232,
-0.029282894,
0.0038655244,
-0.017624447,
0.018002206,
-0.009717545,
0.0127070565,
-0.0023333179,
-0.03433706,
0.014693552,
0.017220635,
-0.013977111,
-0.0035235868,
-0.010870363,
0.009567743,
-0.0075096036,
-0.0006732916,
-0.0098543195,
0.0058585326,
-0.020685604,
-0.002566161,
0.026260816,
-0.039391223,
-0.031106561,
0.0107596405,
-0.01826273,
0.029152632,
0.012967581,
-0.014146452,
-0.008636369,
0.016113408,
0.006050669,
0.018158522,
-0.0008002971,
-0.008160913,
-0.0027713238,
0.013820797,
0.016556298,
-0.0046015047,
0.017298792,
-0.0058845854,
-0.0029716017,
0.03306049,
-0.034910213,
0.00966544,
-0.01943509,
-0.0089945905,
0.010433985,
-0.0049922904,
-0.01987798,
-0.0045363735,
-0.009131365,
0.021949144,
0.010010634,
0.0016868927,
0.015201574,
0.014967103,
-0.0039762473,
0.0027566692,
-0.007157896,
0.018145494,
-0.00676711,
-0.010974572,
-0.0014898714,
0.017455107,
0.020125477,
-0.0037124667,
0.017103398,
0.010792205,
-0.025713716,
-0.012681005,
-0.02467162,
0.04801457,
-0.01853628,
-0.016868927,
0.02511451,
-0.022470193,
-0.03847939,
-0.119841024,
-0.011775684,
0.032331023,
0.0034649689,
0.015748674,
0.028397113,
-0.009847806,
-0.004510321,
0.0026003548,
0.024319913,
-0.025778847,
-0.021219678,
-0.0099910945,
-0.035457313,
0.0429083,
0.023929127,
-0.00044981093,
-0.044393286,
-0.01781984,
0.03423285,
-0.0052039665,
-0.016556298,
0.0045396304,
-0.007014608,
0.012557255,
-0.016738664,
-0.039078597,
-0.0049597253,
0.011691013,
0.014224609,
0.023316896,
-0.0039306553,
-0.0250103,
-0.0010697766,
-0.017728657,
-0.022014275,
-0.0103753675,
-0.015475124,
0.04348145,
-0.0130457375,
-0.010766153,
0.026365027,
0.038505442,
-0.024345966,
0.0027110777,
-0.022326905,
-0.015370915,
-0.0045884782,
-0.013625404,
-0.0077831536,
-0.02374676,
-0.035665732,
-0.014029216,
0.005265841,
0.002186773,
-0.007893876,
-0.0030969786,
0.007340263,
-0.014498159,
-0.010199513,
-0.015188548,
0.01935693,
-0.010837797,
0.031367086,
0.029439209,
-0.0304292,
-0.004028352,
-0.00024668363,
0.019930083,
-0.0020890767,
-0.017038267,
0.011059242,
-0.014276714,
0.001658398,
-0.023525314,
0.009157417,
-0.036160726,
-0.006675927,
0.008812224,
0.015149469,
-0.013755666,
-0.0056794225,
0.020946128,
-0.0063046804,
-0.000069303445,
0.0069625033,
-0.010036686,
-0.006262345,
0.009320245,
-0.044054605,
0.005526365,
0.027328964,
0.006037643,
-0.0028999574,
0.027954223,
0.00002610328,
0.019252721,
-0.018549306,
0.002032087,
-0.018002206,
-0.01641301,
-0.0052756104,
-0.054710034,
0.014823814,
0.023121502,
0.0044289078,
0.0051648878,
-0.01748116,
0.015748674,
-0.012374889,
0.0056175482,
-0.0039567077,
-0.044263024,
0.004070687,
-0.030481305,
-0.0063372455,
-0.02748528,
-0.017520238,
0.022704665,
0.0040446348,
0.012440019,
0.0027534128,
-0.018887987,
0.016373932,
0.020073373,
0.023043346,
-0.005891098,
-0.0181976,
0.0083172275,
0.007633352,
-0.025140563,
0.0047968975,
-0.000628107,
-0.02131086,
0.0011365358,
0.0015851256,
-0.01197759,
-0.014406975,
-0.015709596,
0.022939136,
0.019995214,
0.011769171,
-0.017272739,
-0.0067996755,
0.00086542807,
-0.019982189,
-0.007945981,
0.011489107,
-0.029725784,
0.022874005,
-0.008486568,
-0.030116571,
0.030559462,
0.011059242,
0.005076961,
-0.03128893,
-0.040928315,
0.027745804,
-0.0052756104,
0.019982189,
0.019096408,
-0.009359323,
0.041371208,
-0.0134300105,
-0.012055747,
-0.0058845854,
0.008688474,
0.015253679,
0.00033461046,
0.00538959,
0.018979171,
0.0054221554,
-0.010753127,
-0.016855901,
-0.0018513484,
-0.009072747,
0.02124573,
0.008011112,
-0.013508168,
0.034936264,
-0.004608018,
0.010512142,
0.019278774,
0.011769171,
-0.018835884,
0.014055268,
0.028292904,
-0.003868781,
-0.026807917,
0.015813805,
-0.007411907,
0.0056012655,
-0.011756144,
0.012804753,
-0.0057250145,
0.008362819,
0.005806428,
0.03988622,
0.007275132,
-0.0030106802,
0.008480055,
0.04608669,
0.0012358606,
0.0031897903,
-0.0057868888,
-0.051375326,
-0.0033672724,
0.0064056334,
-0.021649541,
-0.034076534,
0.0050639347,
0.017298792,
0.007496577,
0.028188694,
0.02210546,
0.0036180266,
0.012746136,
0.0016836362,
-0.025335956,
-0.0035170736,
-0.02385097,
0.011502134,
0.012941528,
0.009111826,
-0.005184427,
0.025726743,
0.017793788,
0.023251764,
0.03801045,
-0.0060474128,
0.022847952,
0.0027941195,
0.004630814,
-0.016048277,
-0.0032549214,
0.0033021413,
-0.011502134,
-0.016009199,
0.00278435,
0.003069298,
-0.010460038,
0.06987253,
0.014042242,
-0.010661944,
0.008623344,
-0.012114365,
0.013377906,
0.015136443,
0.0068648066,
-0.009698004,
-0.03126288,
0.0005414014,
-0.0025970982,
0.012557255,
-0.04804062,
-0.011762657,
0.017220635,
0.007718023,
0.0009818497,
-0.009587282,
-0.00981524,
0.008962025,
-0.008734066,
-0.0011169965,
0.00790039,
-0.009359323,
-0.0084735425,
0.010681483,
-0.006688953,
-0.005790145,
-0.018679569,
0.0053993594,
0.020907048,
-0.014485133,
0.006754084,
0.02977789,
-0.021610463,
-0.003235382,
-0.016295774,
0.0086103175,
-0.007822232,
0.012596334,
0.027224755,
-0.019578377,
0.0027973761,
-0.02511451,
-0.035379156,
-0.014159478,
0.00027456784,
-0.0022600454
] |
Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of phenotypic markers. These cells can proliferate and differentiate with approximately unit efficiency into myelomonocytic cells, B cells, or T cells. Thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors. | [
-0.028909126,
-0.012060815,
-0.0058660014,
-0.03787911,
-0.017992578,
0.004938752,
0.005214954,
-0.010817906,
-0.02087297,
0.0013456619,
-0.007095757,
0.018189864,
0.0019942431,
-0.015401541,
-0.018768573,
0.011778036,
0.030908301,
0.0054319697,
-0.0036333697,
-0.0062934565,
-0.030671557,
0.0012314,
0.0030513727,
-0.018097797,
0.004481704,
0.004655974,
0.010291807,
-0.013783787,
-0.006004102,
-0.008411004,
0.02057046,
-0.003163169,
-0.007483755,
-0.018452914,
-0.007319349,
0.0050373957,
0.023398243,
0.0029790343,
0.016598416,
0.0048631253,
0.00019882835,
0.024687184,
-0.006313185,
0.01049567,
0.0047907867,
0.0018018882,
-0.0039062835,
-0.009456625,
-0.00857541,
0.012797353,
0.03217094,
-0.01405999,
-0.009995877,
0.019623484,
-0.03398598,
-0.007621856,
0.010831058,
0.019597178,
-0.01592764,
-0.017913664,
0.0036037765,
-0.015033272,
-0.022977363,
0.0026025448,
0.0026420022,
-0.0004960947,
0.0004173854,
-0.010022181,
0.0068918937,
-0.017321803,
0.02120178,
-0.006977385,
0.0074245688,
-0.011547868,
0.024595117,
-0.0077796853,
-0.0061389147,
0.000028642584,
0.010975735,
-0.012310711,
0.021372762,
-0.028540857,
-0.021320153,
0.0055404776,
0.020675682,
0.0050012264,
0.006615692,
0.007681042,
0.008411004,
0.008036159,
0.024042714,
0.023200955,
0.016138079,
0.008069039,
-0.0017722952,
0.015953945,
0.017729528,
0.024792405,
0.016374825,
-0.035695802,
-0.022622246,
0.016190689,
0.0055437656,
-0.017755833,
-0.027409745,
0.011245361,
0.011685968,
-0.007904634,
0.0199786,
-0.009739404,
-0.024595117,
0.032697037,
0.013034097,
-0.051215716,
0.02652853,
0.011317699,
0.006806403,
-0.0015626778,
-0.0044422466,
0.01896586,
0.032249853,
0.02125439,
0.012034509,
-0.019347282,
0.013889007,
0.036248203,
-0.014901747,
-0.0012848318,
-0.011837223,
0.012507998,
0.021583201,
-0.008660901,
0.00958815,
0.023161499,
-0.009127813,
0.006421693,
-0.0067998264,
0.003281541,
-0.011251938,
-0.026502226,
0.007786262,
0.036511254,
0.016756246,
-0.017190278,
0.001177968,
0.0077796853,
0.017768987,
-0.015348932,
0.0027505101,
-0.008364971,
-0.004866414,
-0.0069510797,
0.03456469,
-0.004169333,
0.002214547,
-0.0018479219,
-0.0058101034,
0.02003121,
-0.017190278,
-0.004126587,
0.0029856104,
-0.02274062,
0.018821184,
0.004961769,
0.012027933,
0.025318503,
0.006812979,
0.002490749,
-0.0020123278,
-0.0012840098,
0.0062638633,
0.037747588,
-0.0047743465,
0.010607466,
-0.019860229,
0.0127842,
-0.008411004,
-0.0076415846,
-0.03559058,
-0.02333248,
-0.010863939,
0.01308013,
0.002301682,
-0.009693369,
-0.006438134,
0.0035972004,
0.02114917,
-0.02141222,
0.0012009848,
-0.01177146,
0.0031056267,
-0.0056785787,
0.017663766,
-0.004096994,
-0.65362513,
-0.01922891,
-0.006115898,
-0.0046691266,
0.023661291,
0.038905002,
0.010870515,
-0.015204255,
-0.02811998,
-0.003166457,
0.005747629,
0.00013923121,
0.009456625,
-0.029750885,
-0.009778861,
-0.03290748,
-0.012369897,
-0.005691731,
0.008305784,
-0.008746392,
-0.028882822,
-0.007575822,
-0.011580749,
0.036695387,
-0.008108498,
-0.0024726642,
0.037274096,
0.00082613947,
-0.019005317,
0.024963386,
0.000058004443,
0.023477158,
-0.003112203,
0.0077468045,
0.04926915,
0.012139729,
-0.009574997,
0.016059164,
0.00466255,
0.03716888,
0.0021159034,
0.013454976,
0.031408098,
0.004060825,
-0.022411807,
0.008535952,
-0.00078997016,
0.011902984,
-0.0013851194,
0.0048039393,
-0.0060172547,
0.021583201,
-0.0155462185,
-0.002245784,
-0.00026572097,
0.0052116658,
0.013356333,
0.0057640695,
-0.0023444276,
-0.0050341077,
0.002436495,
0.014309886,
-0.023095736,
-0.010462789,
-0.0056029516,
0.020281108,
-0.005629257,
-0.017177125,
0.025884058,
-0.025752535,
0.026410159,
0.0143888015,
-0.028803907,
-0.0011417987,
0.002219479,
0.017006142,
0.004606652,
-0.01849237,
-0.00076078816,
-0.007832295,
-0.005103158,
-0.02242496,
0.006977385,
0.008772697,
0.02312204,
0.005438546,
-0.014928052,
0.0056424094,
0.017242886,
0.011791188,
-0.014046837,
0.020096973,
0.022122454,
-0.061763994,
-0.021675268,
0.008713511,
0.0017476344,
0.0060402714,
0.016401129,
-0.038010634,
-0.035196006,
-0.00745745,
0.022175062,
0.008338666,
0.0013982719,
-0.0019514976,
-0.033801846,
-0.010561433,
0.01657211,
-0.029382616,
0.012021357,
-0.0053333263,
-0.002748866,
-0.0084438855,
0.0026206295,
-0.011830646,
0.006388812,
0.017887358,
-0.019136842,
-0.02706778,
0.021596354,
0.010456213,
0.015362084,
0.006326338,
0.011501834,
-0.01161363,
0.018479219,
-0.002189886,
0.0019991754,
-0.022727467,
0.011383462,
0.0033456592,
0.0075889747,
-0.03190789,
0.030145459,
-0.004231807,
0.008213717,
-0.01582242,
0.015296321,
-0.0046395333,
-0.031881586,
-0.0024282746,
-0.010028758,
-0.018939555,
-0.010081368,
0.0011368665,
0.00003426835,
0.00026592647,
0.019794466,
-0.010153706,
-0.009542116,
-0.0072207055,
-0.013402366,
-0.0014064922,
0.025791992,
-0.011034922,
-0.032881174,
-0.021688422,
0.022661705,
-0.020846663,
-0.030645253,
0.005800239,
0.0087924255,
0.023306176,
-0.0020287684,
-0.019570874,
-0.01896586,
0.018334541,
-0.005241259,
-0.02919848,
0.010909973,
-0.01645374,
-0.025542095,
0.0010563077,
-0.013823245,
-0.003728725,
-0.012593489,
-0.015598828,
-0.02008382,
-0.017032448,
-0.000035732588,
-0.01715082,
-0.0032157786,
-0.01254088,
0.02567362,
0.013652263,
0.027041476,
-0.004655974,
0.011988476,
0.031776365,
-0.001824905,
0.027015172,
-0.0046230927,
-0.0022276994,
0.023411395,
-0.02743605,
-0.0027077645,
0.012948606,
0.0007192757,
0.026252327,
0.0022540044,
-0.010212893,
0.009233033,
-0.019728703,
0.01657211,
-0.037773892,
-0.008318936,
-0.022503875,
0.0060435594,
0.011436072,
0.008240022,
0.003728725,
-0.020886121,
-0.008733239,
0.010443061,
-0.002300038,
-0.00080599973,
-0.0075823986,
0.004813804,
-0.01592764,
0.0013530602,
0.026226023,
-0.0071615195,
-0.018045187,
-0.0064151166,
0.004981498,
0.02727822,
0.011633359,
0.009897233,
0.009200152,
0.0010513755,
0.006447998,
0.021320153,
-0.009226457,
0.018808031,
-0.001488695,
0.02551579,
-0.00011128222,
0.01790051,
0.008108498,
0.0039391643,
0.0020008194,
-0.0073653827,
-0.001877515,
-0.0029034074,
-0.023306176,
0.013691721,
-0.004116723,
-0.010482518,
0.028882822,
-0.01694038,
-0.001625974,
-0.017334955,
0.0026962562,
0.0036794033,
0.00006504307,
0.0021126154,
0.015625134,
0.02162266,
0.02349031,
0.015677743,
-0.0068918937,
0.005494444,
-0.029645665,
-0.0000027422384,
0.007398264,
0.011679392,
-0.0024710202,
0.012560608,
0.0017196854,
-0.039562628,
0.013172198,
0.020951884,
-0.013928465,
-0.006171796,
0.010574585,
0.015559371,
0.014204667,
0.013034097,
-0.01363911,
-0.016927227,
-0.026567988,
0.0039194357,
0.02785693,
-0.013783787,
-0.0077731092,
-0.02754127,
-0.028409334,
-0.0033736082,
0.0064578624,
0.03440686,
0.0024743082,
-0.0055996636,
0.0032075583,
-0.0054221055,
-0.024108475,
0.020438937,
-0.012764472,
0.026133956,
0.008292632,
0.0062901685,
-0.013612806,
-0.0079769725,
-0.024213696,
0.015598828,
-0.0015388388,
-0.0032897613,
-0.014099447,
-0.010982311,
-0.010988888,
-0.025976127,
-0.038957614,
0.004570483,
-0.007542941,
0.0010258926,
-0.008529376,
-0.0033933371,
0.020623071,
0.021990929,
-0.00045951438,
-0.015519913,
-0.02429261,
-0.014336191,
-0.008779273,
0.018939555,
0.033538796,
-0.011396615,
-0.0020863104,
0.0027916115,
-0.021109713,
0.0066880304,
-0.010022181,
0.035669494,
-0.004346891,
0.017611155,
0.019939143,
0.0051195985,
-0.011607054,
-0.0040739775,
0.022464417,
-0.008253174,
-0.021885708,
0.009016017,
-0.012705285,
0.002137276,
0.013330027,
0.013119588,
0.026607445,
0.03190789,
0.0026567988,
0.014980663,
0.013494433,
-0.00018875848,
-0.0054780035,
-0.005136039,
0.0059317634,
-0.00056843326,
-0.0027044765,
0.007148367,
-0.035432752,
0.0038207923,
0.019623484,
0.0027521541,
-0.0035314378,
0.032460295,
0.026909951,
0.0060895933,
0.0023871732,
0.00745745,
0.0031845416,
0.016756246,
-0.0029790343,
-0.010206316,
-0.033644017,
0.038484126,
-0.017821595,
-0.035353836,
-0.004600076,
-0.0063986764,
0.033959676,
-0.01720343,
-0.010114249,
-0.01720343,
0.0067998264,
0.0013062046,
-0.02785693,
0.013415518,
0.011896408,
-0.016822008,
-0.00471516,
-0.004317298,
-0.0044422466,
-0.04271922,
-0.0045112967,
0.024384677,
0.009154119,
-0.019847076,
0.00902917,
0.01762431,
0.037694976,
0.01395477,
0.00745745,
-0.025423722,
0.019097386,
0.0073061967,
-0.021635812,
0.005300445,
-0.023595529,
-0.0023953933,
0.017703224,
0.0047546173,
-0.013145893,
-0.021372762,
0.0019169723,
0.0050012264,
-0.0127513185,
0.00052527676,
-0.01933413,
-0.012849962,
0.014875443,
-0.0060468474,
0.0041397396,
-0.018242475,
-0.0036530984,
-0.015533066,
-0.020794054,
-0.041351363,
-0.01329057,
-0.0276991,
-0.011363734,
-0.01587503,
0.010521975,
-0.028751297,
-0.015493609,
0.0170456,
-0.0110020405,
0.02658114,
0.004340315,
0.0037747587,
0.01395477,
0.013356333,
0.014112599,
0.026252327,
0.011232208,
-0.0006662548,
-0.018781725,
0.016953534,
0.0030941183,
-0.034485772,
0.004708584,
-0.0010998752,
-0.01363911,
-0.019373586,
-0.0072207055,
-0.008838459,
0.04250878,
-0.020965036,
-0.022595942,
-0.029645665,
-0.022096148,
0.013435247,
0.017216582,
0.0010176722,
-0.01459924,
-0.01004191,
0.02195147,
-0.0024825286,
-0.0031023386,
0.002494037,
-0.025436874,
-0.012948606,
0.04516558,
0.013665415,
-0.011679392,
-0.018360848,
0.011810917,
0.0034821162,
-0.020018058,
-0.024634575,
-0.034222726,
0.024923928,
-0.016046012,
0.04064113,
0.03893131,
0.019307824,
0.013652263,
0.025331656,
0.005017667,
-0.0036267934,
0.013560195,
0.008193988,
0.028777603,
-0.0067932503,
0.011186175,
-0.0054319697,
-0.0030924743,
0.005609528,
-0.020754596,
0.023187803,
0.02754127,
-0.0028705264,
-0.016808856,
0.0038503853,
-0.046533436,
-0.03706366,
0.014415106,
0.0046230927,
-0.0006115898,
-0.016493196,
-0.002295106,
0.035669494,
-0.018374,
0.0033966252,
0.014125751,
0.04016764,
-0.004090418,
0.012935453,
-0.00943032,
-0.0034788281,
-0.003141796,
0.008996289,
-0.0062474227,
-0.015743505,
0.0068261316,
0.010350993,
-0.0073653827,
0.0076152794,
-0.029066958,
0.015033272,
0.002495681,
-0.031197656,
-0.010837634,
-0.015362084,
-0.014217819,
-0.01379694,
-0.008378123,
-0.037353013,
-0.0018479219,
0.012646099,
0.017124515,
-0.017926816,
0.004202214,
0.003194406,
-0.027409745,
0.030171763,
-0.026081346,
0.027225612,
-0.023832275,
0.008877916,
0.028172588,
0.001795312,
-0.025344808,
-0.00847019,
-0.01171885,
0.009910385,
0.038221076,
0.02647592,
-0.030382203,
-0.021083407,
-0.0064052525,
0.0058101034,
-0.016190689,
-0.03664278,
0.008963408,
-0.019149994,
0.00073900435,
-0.015230559,
-0.01790051,
-0.030671557,
0.015467304,
0.011830646,
0.0022030387,
0.019044776,
-0.012771048,
-0.031066133,
0.04556015,
-0.0069971136,
-0.00034422477,
0.0037648943,
-0.0051228865,
0.010508823,
-0.030013934,
-0.03398598,
-0.0054878676,
-0.010508823,
0.034222726,
-0.018374,
0.002242496,
0.023687597,
-0.009752556,
-0.013757483,
-0.013494433,
-0.0023460716,
0.036406033,
-0.015151644,
0.013652263,
-0.010515399,
0.009298796,
0.0004455399,
-0.013560195,
-0.03606407,
0.012876268,
-0.02333248,
-0.008457038,
0.034170114,
0.019676093,
-0.010988888,
0.0043304507,
-0.030566338,
-0.02018904,
-0.03772128,
-0.031776365,
-0.0075363647,
-0.04235095,
0.005195225,
0.011554444,
0.018992165,
0.008371547,
-0.0036300814,
0.009246185,
0.0077007706,
0.03367032,
0.009108085,
0.026278634,
0.023595529,
0.035169702,
-0.032802258,
-0.014980663,
0.0015889826,
-0.011981899,
-0.011955595,
-0.015335779,
-0.01486229,
-0.012100272,
-0.014691308,
0.020110125,
0.0012461965,
-0.01779529,
-0.006645285,
0.007996702,
0.04282444,
0.01025235,
-0.009706522,
0.0199786,
-0.034064896,
-0.006760369,
-0.012705285,
-0.0055371895,
-0.017939968,
-0.010568009,
-0.00084134704,
-0.0114558,
0.00025400706,
-0.011508411,
-0.020531004,
0.008003278,
0.00072585186,
0.0051459037,
-0.02562101,
-0.0009362914,
-0.005080141,
0.0008368259,
0.0014106024,
-0.0072207055,
-0.00857541,
0.022937907,
0.007122062,
0.024161085,
-0.008489919,
0.0037353013,
0.006447998,
-0.018610744,
-0.030724168,
-0.0008639528,
-0.015782963,
0.054346003,
0.004225231,
0.016466891,
-0.03787911,
0.005517461,
-0.038431514,
-0.034485772,
0.014020532,
0.017650614,
-0.002135632,
0.01182407,
-0.016743094,
0.0062638633,
-0.008877916,
0.007832295,
-0.0074442974,
-0.028409334,
0.018992165,
0.010791601,
0.0034064895,
0.01177146,
-0.015953945,
-0.01832139,
0.016124927,
-0.023963798,
0.012073967,
0.015625134,
-0.00801643,
0.024516203,
0.0031335757,
0.030881997,
0.008529376,
0.011639935,
0.0055339015,
-0.01715082,
-0.009923538,
0.017190278,
-0.0113571575,
-0.0047250246,
-0.004915735,
0.0038470973,
0.008910798,
-0.0037484537,
-0.027725404,
-0.013027521,
0.016966686,
-0.019781314,
0.011745155,
0.005517461,
-0.0034130658,
0.020728292,
-0.006983961,
0.0016802279,
-0.0033045579,
0.009390863,
0.0040838416,
-0.01243566,
-0.0132182315,
-0.004228519,
0.012869691,
0.008463614,
-0.0025137656,
-0.008549104,
0.0035018448,
0.004432382,
-0.019413045,
-0.01886064,
0.019136842,
0.001038223,
-0.017966272,
-0.009857776,
-0.0075889747,
-0.011850375,
-0.028567163,
-0.012764472,
-0.005412241,
-0.010692958,
-0.019202605,
0.010028758,
0.008595139,
-0.017821595,
0.015677743,
0.013303722,
0.018715963,
0.03966785,
0.18771204,
-0.031171352,
0.017400717,
0.020281108,
-0.0030086273,
-0.018255627,
0.02988241,
0.0018265492,
0.016664179,
0.023503462,
0.032854866,
-0.00026962563,
0.004379772,
-0.0043041455,
0.019163147,
-0.018203016,
-0.010324689,
-0.007970396,
-0.020741444,
-0.019399893,
-0.0060139666,
0.0008910798,
0.035616886,
-0.006109322,
0.019860229,
0.020465242,
-0.02157005,
0.018439762,
0.014875443,
-0.0042942814,
-0.026857343,
0.004550754,
-0.010180011,
0.0028146284,
0.016019708,
-0.012494845,
-0.010272078,
-0.009417168,
0.0014056701,
-0.00745745,
-0.015085882,
0.0067340643,
-0.0016621433,
0.015901335,
0.0039194357,
0.043771416,
-0.0128631145,
0.016756246,
0.00621783,
-0.010002453,
-0.028540857,
0.003222355,
0.0052248184,
-0.0061816606,
0.004965057,
-0.006230982,
0.0234377,
0.006977385,
0.0025647315,
0.026909951,
-0.011574172,
-0.0015791183,
-0.030803083,
0.02935631,
-0.00069379277,
0.016637873,
-0.006168508,
-0.005142615,
0.02668636,
0.0022211233,
-0.021872556,
-0.005356343,
-0.015743505,
0.00071023335,
0.011462376,
-0.01858444,
0.010101097,
0.018387152,
-0.0050669885,
-0.016979838,
-0.0059646447,
-0.0053826477,
-0.018900098,
0.010337841,
-0.0018462779,
-0.02759388,
0.009542116,
0.012968334,
-0.0026699512,
-0.020649377,
0.003194406,
-0.012968334,
-0.00065803446,
0.0006391278,
0.017479632,
0.00079243624,
0.013902159,
0.017348107,
-0.014835985,
-0.02189886,
-0.031513315,
0.06939243,
0.019860229,
-0.0023427836,
0.00029757462,
0.010942854,
-0.013704873,
-0.0045770593,
-0.008108498,
0.0075495173,
0.016506348,
-0.034959264,
-0.000094841635,
-0.014323039,
0.002046853,
0.019689247,
0.0072470102,
-0.034012284,
0.014073142,
-0.0044093654,
-0.0014558139,
-0.030382203,
0.005027531,
0.024647728,
-0.013612806,
0.008411004,
-0.014217819,
0.013875855,
-0.01121248,
-0.022293435,
-0.026515378,
-0.006395388,
0.0038766903,
0.018505525,
-0.00041882394,
0.004205502,
-0.012192339,
-0.0019712264,
-0.04766455,
-0.008785849,
-0.0056555616,
-0.012790776,
0.0020863104,
0.0062112533,
0.013652263,
-0.0072733155,
0.025265893,
0.015243712,
-0.024253152,
-0.012692133,
-0.014428259,
-0.02754127,
-0.027251916,
-0.008930527,
0.015533066,
-0.012317288,
-0.010936278,
-0.01832139,
0.004429094,
0.025936669,
-0.015533066,
0.026607445,
-0.005514173,
-0.0073259254,
-0.0030661693,
-0.008825307,
-0.16519502,
0.007069452,
0.0458232,
-0.018610744,
0.02988241,
-0.0024480033,
-0.0032700326,
-0.017650614,
-0.0125211505,
-0.0018199729,
0.02743605,
0.01019974,
-0.03324944,
-0.017729528,
0.0051623443,
0.0038898427,
-0.0018955996,
0.056555618,
0.008134802,
0.008193988,
0.019255215,
-0.0018742268,
0.01657211,
-0.008542528,
0.006313185,
-0.004146316,
0.008253174,
-0.0050669885,
0.01608547,
-0.024621421,
-0.02349031,
-0.009811742,
0.0021964624,
-0.0056226803,
-0.0048072273,
-0.008910798,
0.0011870103,
-0.012264677,
0.012310711,
0.018755421,
0.035722107,
-0.001039867,
-0.008785849,
-0.0010020537,
-0.003197694,
0.041351363,
0.0017722952,
-0.00420879,
0.016795702,
-0.0024989692,
0.011383462,
-0.028856518,
-0.00464611,
0.011889832,
0.02754127,
0.014336191,
0.014178362,
0.0140336845,
0.013468129,
0.01795312,
0.0007603771,
-0.017966272,
0.024621421,
-0.026357548,
0.003955605,
-0.025134368,
-0.003810928,
0.018150408,
-0.012711861,
-0.016046012,
-0.016019708,
0.0071023335,
0.022096148,
-0.020110125,
0.025384266,
0.015138492,
0.009364558,
-0.00005908336,
-0.004317298,
0.0069116224,
-0.020215346,
0.04171963,
-0.014678155,
-0.008128226,
-0.016164385,
0.0057673575,
0.016164385,
0.006257287,
0.0004180019,
-0.014336191,
0.0000800451,
-0.020965036,
-0.021320153,
-0.024476744,
0.022753771,
0.026068194,
-0.021543745,
-0.03966785,
0.012244949,
0.007996702,
0.020228498,
-0.021648964,
-0.012567184,
0.00008949844,
0.0447447,
-0.01470446,
-0.0009124525,
0.002747222,
0.028014759,
-0.004399501,
-0.00056678924,
0.01629591,
0.011337428,
0.028277809,
0.01678255,
0.022398654,
0.01683516,
0.005895594,
-0.014375648,
-0.0298298,
0.061290506,
0.00908178,
-0.025528943,
0.033591405,
-0.0015330847,
-0.00943032,
-0.14551891,
-0.010337841,
-0.009252762,
0.0010209604,
-0.013862702,
0.015072729,
-0.0017772274,
0.0016810499,
0.008818731,
0.024437288,
-0.016822008,
-0.016558958,
-0.0053135976,
-0.006175084,
0.020162735,
0.00812165,
0.005773934,
-0.00745745,
-0.0132182315,
0.023963798,
0.00047020076,
-0.0005199335,
-0.016611569,
-0.01105465,
0.021990929,
0.017650614,
-0.043534674,
0.018439762,
0.009397439,
0.038747173,
0.022385502,
-0.013454976,
0.01353389,
-0.011574172,
-0.012882844,
0.013691721,
-0.008503071,
-0.029856104,
0.025647314,
-0.028961737,
-0.010107673,
0.03564319,
-0.008706935,
-0.03185528,
0.014507174,
-0.01137031,
-0.023503462,
0.003672827,
0.0053399024,
-0.02833042,
-0.035038177,
-0.014204667,
-0.025686773,
-0.006707759,
0.02445044,
-0.015296321,
0.0029083397,
0.007635008,
-0.023161499,
-0.01486229,
0.021451676,
-0.016703635,
0.003140152,
0.009673641,
0.022043537,
-0.017834747,
-0.022503875,
-0.0072798915,
0.014138904,
-0.0394048,
-0.008831883,
0.0046395333,
-0.016046012,
-0.0002607888,
-0.00050143787,
-0.007838871,
-0.011482106,
-0.015388389,
0.012942029,
-0.01329057,
-0.010975735,
-0.0092593385,
0.015440999,
-0.007154943,
0.021030799,
0.008601715,
0.019057928,
-0.00008025061,
0.0069576562,
0.00831236,
-0.008884493,
0.03872087,
-0.016585264,
-0.014612393,
-0.008799002,
0.008371547,
0.018623896,
0.0006843394,
0.022753771,
0.03948371,
-0.0112387845,
-0.006641997,
-0.047322582,
0.023845427,
0.0023378513,
-0.0024726642,
0.017163971,
-0.03659017,
0.018623896,
-0.027935844,
0.02327987,
0.00054130633,
-0.005803527,
0.0051787845,
-0.021109713,
0.011376886,
-0.0060830167,
-0.0022079707,
0.025094911,
-0.008411004,
0.014559783,
0.013612806,
-0.004179197,
-0.014007379,
0.01416521,
-0.0064677265,
0.0050110905,
0.00016625543,
-0.01795312,
0.033459883,
-0.008884493,
0.002050141,
0.0015076018,
-0.031092437,
-0.01603286,
0.0055108843,
-0.012909149,
-0.017006142,
0.012646099,
0.019413045,
0.02668636,
0.026147109,
-0.005625969,
-0.024937082,
0.005573359,
0.00020006139,
-0.008141378,
-0.000057285168,
-0.015519913,
0.008772697,
-0.0067209117,
-0.007095757,
0.046191473,
-0.0076087033,
0.008831883,
-0.038773477,
-0.025344808,
0.0034656755,
0.0057673575,
0.005718036,
-0.011672816,
-0.017032448,
0.010956007,
0.020741444,
0.0035215735,
-0.00088121544,
-0.03590624,
-0.026436463,
0.010186587,
0.010778449,
-0.012915725,
-0.027383441,
-0.025173826,
0.017058752,
0.01849237,
0.007983549,
0.024674032,
-0.0027801031,
-0.0069576562,
0.018544981,
-0.006865589,
0.014467716,
0.009351405,
-0.020701986,
-0.015059577,
0.0029050517,
0.04542863,
0.008601715,
-0.02162266,
0.03964154,
-0.008654324,
-0.0026009008,
-0.011929289,
0.015362084,
0.02226713,
0.0034426588,
0.017137667,
0.03840521,
-0.0045047207,
0.017598003,
0.012027933,
0.02594982,
-0.0072798915,
-0.014152057,
0.022477569,
-0.040983092,
-0.013731178,
0.028724993,
-0.03979937,
-0.03222355,
-0.033433575,
0.0041397396,
0.009890657,
0.032697037,
-0.0025581552,
0.012126576,
-0.023174651,
0.011291395,
0.00036950217,
-0.008167683,
-0.012771048,
0.060606577,
0.008240022,
0.01459924,
-0.00015423325,
-0.007792838,
0.009272491,
0.005520749,
0.020360023,
-0.021977777,
0.015782963,
0.005898882,
0.02743605,
0.0074442974,
-0.022359198,
-0.0020550734,
-0.0063460665,
-0.01329057,
0.031013522,
0.017163971,
-0.008029582,
0.075495176,
-0.0053662076,
-0.006697895,
-0.008930527,
-0.027409745,
0.026265481,
0.030960912,
0.011205903,
-0.0106534995,
-0.018097797,
0.028961737,
-0.02258279,
0.027830625,
-0.014928052,
-0.037247792,
0.014901747,
-0.0055470536,
-0.0067472165,
-0.012198915,
-0.016440587,
0.0040871296,
-0.023450851,
0.02322726,
0.019860229,
-0.016269604,
-0.0029017634,
0.013547043,
-0.03201311,
-0.005583223,
-0.0069445036,
0.026988866,
-0.010055062,
-0.045402322,
-0.009371134,
0.00008888192,
-0.003140152,
-0.0006424159,
-0.04027286,
0.002860662,
0.02087297,
0.00071434345,
0.009897233,
-0.01019974,
-0.0040246556,
-0.010278654,
-0.016506348,
-0.026936257,
-0.019912839,
0.006477591
] |
Bacteria such as Escherichia coli will often consume one sugar at a time when fed multiple sugars, in a process known as carbon catabolite repression. The classic example involves glucose and lactose, where E. coli will first consume glucose, and only when it has consumed all of the glucose will it begin to consume lactose. In addition to that of lactose, glucose also represses the consumption of many other sugars, including arabinose and xylose. In this work, we characterized a second hierarchy in E. coli, that between arabinose and xylose. We show that, when grown in | [
0.0007525892,
-0.01811554,
0.0078496225,
-0.044774886,
-0.015272054,
0.013489869,
-0.0013625035,
-0.012061452,
-0.012168249,
-0.019664105,
0.01989105,
0.0027467003,
0.007369033,
0.010119071,
-0.02298818,
0.008924273,
0.041784555,
0.008944297,
-0.019650755,
0.018275736,
-0.018329134,
0.015846092,
0.020224793,
-0.019090068,
-0.006554702,
0.0088108005,
0.01457787,
-0.023442069,
-0.0033374245,
0.011086924,
0.011560839,
-0.010679758,
-0.011280495,
0.0057904315,
-0.029689727,
-0.032065973,
0.013056004,
-0.00011639268,
0.017381307,
0.0006069941,
0.01591284,
0.010259243,
-0.0037212283,
0.034335423,
0.003067093,
-0.009665181,
-0.01806214,
-0.010012274,
0.00027867494,
0.0025764918,
0.017167712,
0.024950584,
-0.018983271,
0.00791637,
-0.014030532,
0.009865426,
-0.004238529,
0.003253989,
0.0019056693,
-0.011607562,
-0.016740521,
-0.004772517,
-0.025871715,
0.007776199,
0.005266456,
0.01325625,
0.013830287,
0.009992248,
0.010232544,
0.011267145,
0.0027567125,
0.011407317,
0.022147149,
0.018195638,
0.02165321,
-0.03631118,
-0.027326832,
0.008183365,
0.016660422,
0.010653059,
0.0029786513,
-0.011080249,
-0.039087914,
0.024002757,
0.010826605,
-0.017621601,
0.025070732,
0.0068350453,
-0.014657969,
0.0014117305,
0.038714122,
0.035803888,
0.024897186,
0.0046423576,
-0.022187198,
0.021586461,
-0.02167991,
0.067282476,
-0.010339341,
-0.01947721,
-0.010325992,
0.020251492,
-0.012809035,
-0.020051247,
-0.0031622096,
0.0072822603,
-0.0021576448,
-0.012368495,
-0.00045806152,
-0.016486878,
-0.012708913,
0.041143768,
0.017087614,
-0.04910019,
0.022908082,
0.012989256,
0.019183517,
-0.014978361,
-0.009004371,
-0.008016493,
0.01900997,
0.010859979,
0.0049460633,
-0.017528154,
0.0037546025,
0.0029502832,
-0.00973193,
-0.007896346,
-0.022147149,
-0.027220033,
0.0098320525,
0.0154456,
-0.009885451,
0.03126499,
-0.006257671,
0.011247121,
-0.027847469,
-0.0005043683,
0.00054149714,
-0.020611934,
0.008316861,
0.013843637,
-0.009444911,
0.00076635607,
0.0013533257,
0.01812889,
0.01545895,
0.017047564,
-0.007923046,
0.0134231215,
0.010125746,
-0.014417673,
0.028541654,
-0.014778116,
0.04287923,
0.015539048,
0.000057883455,
0.01814224,
-0.029422734,
-0.0098320525,
0.001954062,
-0.005490063,
-0.011707685,
-0.0049560755,
0.022507591,
0.034789313,
0.018329134,
0.012074802,
-0.00033207375,
-0.011440691,
-0.004515535,
0.015245355,
-0.013583317,
0.0114740655,
0.018035442,
0.029449433,
0.0028267985,
0.016073037,
-0.022761235,
-0.009197942,
0.009858752,
0.030597508,
0.024149604,
0.0049627502,
-0.006571389,
-0.01859613,
0.0067582848,
-0.013276274,
0.021279419,
-0.008156666,
-0.011347244,
0.030357214,
-0.005903904,
-0.0011781108,
-0.6356592,
-0.020425038,
0.009191267,
-0.011680986,
0.0074758306,
0.018289085,
0.008143316,
-0.011707685,
-0.008610555,
0.011841182,
0.0113205435,
-0.0059005665,
0.0039515104,
-0.0041484185,
-0.0071153888,
-0.028408157,
0.0113205435,
-0.010906703,
0.00088274875,
0.01304933,
-0.029502831,
-0.008243439,
-0.018235687,
-0.004512198,
0.013162802,
0.034682516,
0.03668497,
-0.017955344,
-0.0046590446,
0.008203389,
-0.008236764,
0.032626662,
0.020905627,
-0.0061708977,
0.04765842,
0.0030120255,
-0.01368344,
-0.004221842,
0.020465087,
0.015725944,
-0.004679069,
-0.01850268,
0.0242831,
-0.0023612278,
-0.006778309,
0.022774585,
-0.0053065047,
0.033294145,
0.007636027,
-0.013636717,
-0.0037379153,
0.012074802,
-0.017461404,
-0.020131344,
0.043947205,
0.021372866,
0.009545034,
-0.031131495,
0.012602115,
0.011861207,
0.0013091047,
0.0048159035,
-0.008216739,
-0.003015363,
-0.04322632,
0.01679392,
-0.027126586,
-0.0027567125,
0.019730853,
0.009077795,
0.03625778,
0.011146998,
0.0029736452,
0.005006137,
0.009738605,
0.016940767,
0.004071658,
0.00607745,
-0.0069685425,
-0.005880542,
-0.01679392,
0.010880004,
-0.038126737,
0.0031154857,
0.022374094,
0.00751588,
-0.030811103,
0.00907112,
-0.030784404,
-0.028087765,
0.01636673,
0.029209139,
-0.053318694,
-0.031211594,
-0.012108176,
0.02385591,
-0.037699547,
-0.018983271,
0.020224793,
-0.014644618,
-0.009231316,
-0.008423659,
-0.0047124433,
0.0035944062,
0.018889822,
-0.0063344315,
-0.009578408,
0.0027934243,
0.03003682,
-0.029716427,
-0.0059873397,
-0.011173697,
-0.011801133,
0.020011198,
0.0068183583,
-0.023268523,
0.008330211,
0.015045109,
-0.007822923,
-0.028808648,
0.020531835,
0.021733308,
-0.0079430705,
-0.008069892,
-0.0050595356,
0.015178607,
0.031612083,
-0.031051397,
-0.0038680749,
0.008416984,
0.0029018905,
-0.0038013265,
0.014270827,
-0.009985574,
0.02652585,
0.020478437,
0.025070732,
-0.0043753632,
0.013897035,
-0.018542731,
-0.029636329,
-0.012575415,
0.00038693266,
0.008930948,
0.005199707,
0.004528885,
-0.032920353,
-0.0035410074,
-0.002209375,
0.0051696706,
0.015151907,
-0.0010888347,
-0.006558039,
0.009424887,
-0.006204272,
-0.00028013508,
-0.035830587,
-0.023455419,
-0.031158194,
0.010826605,
0.016006287,
0.0051229466,
0.0014175711,
-0.0026482462,
-0.02297483,
-0.002870185,
0.025711518,
0.00947161,
-0.028968845,
0.0022827983,
-0.022387443,
-0.02515083,
-0.008290162,
0.024243051,
0.014030532,
0.023642315,
-0.026285555,
0.040396187,
0.012074802,
-0.007595978,
0.029209139,
0.0051529836,
-0.012081477,
0.006361131,
0.008049868,
0.015672546,
0.008910923,
-0.0024563444,
0.0065380144,
0.011874557,
0.005022824,
0.02607196,
-0.0045722714,
-0.0080365185,
0.006961867,
-0.017421355,
-0.0003057915,
0.0072755856,
0.0012982581,
0.018983271,
0.0036177682,
-0.021733308,
0.008590531,
-0.034282025,
0.010619685,
-0.03209267,
-0.002446332,
-0.038367033,
0.039515104,
0.017968694,
0.0052430937,
-0.013329674,
-0.0014058901,
0.015352152,
0.013923734,
0.02473699,
-0.0036544797,
0.005803781,
-0.001234847,
-0.0070953644,
-0.010386065,
0.007769524,
0.0220537,
-0.006825033,
-0.014564521,
0.023348622,
0.0069151437,
0.018462632,
-0.0242564,
-0.006534677,
0.01084663,
0.02830136,
-0.0037212283,
0.0028251298,
0.019637406,
0.024910536,
0.01193463,
-0.0054433392,
0.026872942,
0.00053565664,
-0.021052474,
0.01855608,
0.011594213,
0.018742975,
0.008637254,
0.02515083,
0.0353233,
0.02609866,
-0.032039274,
0.011106948,
-0.01415068,
0.023028228,
-0.014524471,
-0.013056004,
-0.023348622,
0.012782335,
0.020451738,
0.025110781,
0.03270676,
0.005793769,
-0.011267145,
-0.013610017,
-0.007028616,
-0.019383762,
-0.00314886,
0.005236419,
0.010426114,
-0.031024698,
-0.013249575,
0.004078333,
-0.033454344,
0.015685895,
0.009571733,
-0.0035243202,
0.0041951425,
0.0017888595,
-0.021946903,
-0.020531835,
0.019757552,
-0.0011055218,
0.009631807,
-0.015378852,
0.02824796,
0.032840256,
-0.0044721486,
-0.004896002,
-0.0176483,
-0.00839696,
0.00882415,
-0.0049360506,
0.0022627737,
0.026806192,
0.019143466,
0.012855759,
-0.024750339,
0.016927417,
0.014524471,
-0.02385591,
0.0117210345,
0.0070019164,
0.010038973,
0.0034375472,
-0.009845402,
-0.00065330084,
0.070966996,
-0.0154989995,
0.006000689,
-0.012114851,
0.0040182592,
-0.0487264,
-0.009565058,
0.016540276,
-0.0077494998,
-0.0001977424,
-0.019917749,
0.010726483,
-0.014417673,
0.006454579,
0.014711367,
-0.03417523,
-0.013189501,
-0.03575049,
0.012134875,
-0.0036511424,
0.022654437,
0.008970997,
-0.016620373,
0.02163986,
0.00017177306,
0.010993476,
-0.006367806,
-0.020478437,
0.00907112,
-0.0149116125,
-0.027767371,
0.0091512175,
0.03719226,
-0.019503908,
0.03142519,
0.0089042485,
-0.016940767,
-0.03655147,
-0.0052798055,
0.028061064,
0.035002906,
-0.017901944,
0.021065824,
0.008350236,
0.022187198,
0.01192128,
0.019637406,
0.0220537,
-0.0068684197,
-0.017501453,
0.008123291,
-0.011801133,
0.0052697933,
0.011534139,
0.0043152897,
0.007055315,
0.020251492,
0.004128394,
-0.004238529,
0.023442069,
0.016126435,
0.011187047,
0.0033774734,
0.00951166,
-0.02561807,
-0.017007515,
-0.021893505,
0.039168015,
-0.004562259,
-0.03938161,
0.03700536,
-0.034068428,
-0.0072555607,
-0.003921474,
0.016206533,
-0.014070582,
0.004004909,
-0.0040182592,
-0.011774434,
-0.01678057,
-0.004739143,
-0.0063010575,
0.027713973,
-0.00930474,
-0.00045222102,
0.018983271,
-0.0038180135,
-0.025724867,
-0.009698556,
-0.02476369,
-0.013136103,
-0.031745583,
-0.0013858655,
0.008957647,
0.02073208,
0.024670241,
-0.0045322226,
-0.0024847125,
-0.014965012,
-0.005553474,
-0.0048726397,
0.0010454482,
-0.002516418,
-0.046083156,
0.014778116,
-0.0023962709,
0.027420279,
-0.025911763,
-0.039942294,
-0.016580325,
-0.0046690567,
0.005329867,
0.01192128,
-0.007422432,
-0.009024396,
0.008577181,
0.01636673,
0.0056135477,
-0.00094282243,
-0.038740825,
-0.011680986,
0.005293155,
-0.011060225,
0.018636178,
-0.014564521,
-0.014764766,
-0.017354608,
0.0058071185,
-0.006157548,
0.0130226305,
0.013056004,
-0.007028616,
-0.0058705295,
0.016994165,
0.016914068,
0.01325625,
-0.009585083,
0.010693108,
0.022614388,
-0.015846092,
0.0038647375,
-0.017675,
0.013623367,
0.0026899641,
-0.029823225,
0.017354608,
-0.026325604,
-0.039435007,
-0.011981354,
0.009585083,
-0.020091295,
0.030277114,
-0.0027116574,
-0.008323536,
-0.03665827,
0.029022243,
-0.018275736,
0.018475981,
-0.017941995,
-0.01635338,
-0.022334045,
0.013549943,
0.0155924475,
-0.046083156,
-0.001328295,
-0.03623108,
-0.007015266,
0.017034214,
-0.005663609,
0.014684668,
-0.0077494998,
-0.012041427,
-0.011554164,
-0.0004163437,
-0.013142778,
-0.016887369,
0.00027220868,
0.010813255,
0.06333096,
0.023962708,
0.016032986,
-0.02256099,
0.023161726,
0.0006933499,
0.0051763454,
0.004291928,
-0.001208982,
0.011020175,
-0.010272592,
-0.0093981875,
0.0005569327,
0.004812566,
0.009418212,
0.00215097,
0.02875525,
0.033214048,
-0.0043620137,
-0.020371638,
-0.01723446,
-0.011434016,
-0.0113205435,
0.021800056,
-0.008950972,
0.0010354359,
-0.018022092,
-0.030277114,
0.021773357,
-0.0022427493,
0.029983422,
0.0007096199,
0.024963936,
-0.019810952,
0.041277267,
-0.0021760007,
-0.0056702844,
-0.021893505,
-0.024149604,
0.013002606,
-0.016860668,
0.012288397,
0.01149409,
-0.0026699395,
-0.014884913,
-0.022894733,
-0.026018562,
0.007642702,
0.0054433392,
-0.017941995,
-0.005606873,
-0.028781949,
-0.0150050605,
-0.002614872,
-0.01903667,
-0.046296753,
-0.021559762,
0.003948173,
-0.03753935,
0.024883837,
-0.022160498,
-0.013416447,
0.023215124,
0.020932326,
0.03230627,
-0.021119222,
0.03721896,
0.00408167,
0.020838879,
0.0024112891,
-0.00087774266,
-0.016219882,
-0.0062776953,
0.03847383,
0.00596064,
0.017047564,
-0.031051397,
-0.0048325905,
0.016820619,
-0.0035810564,
-0.023495467,
0.014551171,
0.008977672,
-0.016660422,
-0.024069505,
-0.008416984,
-0.008310187,
0.0019156816,
-0.0066314624,
0.0038880995,
-0.0030420623,
-0.017274508,
-0.024323149,
0.021226019,
0.0077628493,
0.012662188,
0.0013007611,
-0.020091295,
-0.02744698,
-0.020651983,
-0.026285555,
0.022067051,
-0.01102685,
-0.0037479277,
-0.00209924,
0.022400793,
0.009017721,
-0.00048392656,
-0.01591284,
-0.003781302,
-0.007035291,
0.030303814,
0.006441229,
-0.017327908,
-0.019290313,
0.023895958,
0.027713973,
-0.0053899405,
-0.008149991,
-0.01943716,
-0.021786707,
0.0018689577,
0.017621601,
0.019837651,
-0.019290313,
-0.009051095,
-0.0088708745,
-0.0016069699,
-0.027607175,
-0.008490408,
0.023014879,
-0.0027733997,
-0.009992248,
-0.0074558062,
0.022641087,
0.023081627,
-0.024857137,
0.0025598046,
-0.022374094,
0.019517258,
-0.028808648,
0.04293263,
0.004515535,
-0.003258995,
0.0010679759,
0.016446827,
-0.0015427244,
-0.0030520747,
0.021786707,
-0.00817669,
-0.009792004,
-0.03799324,
0.0026866267,
0.015058459,
0.019156815,
-0.0020708719,
0.0025180867,
-0.0050828974,
0.029849924,
-0.0053966152,
0.0002016013,
0.00024050316,
-0.017541504,
0.010726483,
0.030837802,
-0.022881381,
0.005920591,
-0.0018572767,
-0.023188425,
0.00819004,
0.0063477815,
-0.02824796,
-0.011734384,
0.034255326,
0.008410309,
0.0031772282,
0.026405701,
-0.008183365,
-0.00729561,
0.010285942,
-0.0069084684,
-0.005573499,
-0.007015266,
-0.009998924,
-0.014871564,
-0.016286632,
-0.0037245657,
-0.009905476,
0.009685206,
-0.0030353875,
-0.016406778,
0.0022243934,
-0.013249575,
0.020999074,
-0.012975906,
-0.036017485,
-0.016313331,
-0.01548565,
-0.01413733,
-0.008103266,
-0.0112871695,
-0.017087614,
-0.0056802966,
-0.030410612,
-0.0077628493,
0.0010062335,
-0.014030532,
0.019343711,
-0.011747734,
0.00342086,
-0.0016078042,
0.013750189,
0.0007154604,
0.0058171307,
-0.026312254,
-0.02472364,
0.027139936,
-0.011240446,
0.016273282,
0.028915446,
-0.004842603,
0.023882609,
-0.009404862,
0.0059539652,
0.029449433,
0.030624207,
0.024323149,
-0.0074424567,
-0.00037233141,
0.025097432,
-0.004999462,
-0.013109404,
-0.016139785,
-0.007175463,
0.004001572,
0.027340181,
0.01014577,
-0.028595053,
-0.009812028,
0.0031238294,
-0.00024154609,
0.02744698,
0.007642702,
-0.010880004,
0.009685206,
-0.021573111,
-0.016233232,
0.014711367,
-0.031238293,
0.008363586,
0.015272054,
0.004355339,
-0.027580475,
-0.017341258,
-0.0000950123,
0.0067449347,
0.0048859892,
0.008149991,
-0.018235687,
-0.0021709946,
0.020651983,
0.0064512417,
-0.022627737,
-0.028434856,
0.023041578,
-0.013042655,
-0.0043353145,
0.0056335726,
0.016914068,
-0.007696101,
-0.002127608,
-0.0026983076,
-0.0066548246,
0.0061208364,
-0.017581552,
0.012728937,
-0.029075641,
-0.009324764,
0.17354608,
-0.014310876,
0.032840256,
0.045255475,
-0.0143242255,
-0.025444524,
-0.023295222,
-0.010906703,
-0.005126284,
0.014484422,
0.0032389704,
-0.003647805,
-0.011941304,
-0.002024148,
-0.0008230923,
0.009358138,
-0.04239864,
-0.023161726,
-0.009578408,
-0.026419053,
0.007128739,
0.0053365417,
-0.011167022,
-0.023749113,
0.040449586,
-0.0049627502,
-0.013803587,
0.013736839,
0.02384256,
0.0093381135,
-0.010572961,
0.02736688,
-0.006761622,
0.005356566,
0.0017972031,
0.011654287,
0.0031338416,
0.0033657926,
0.0052631185,
0.013856987,
-0.004071658,
-0.013209526,
0.019357061,
0.017781798,
-0.019210216,
0.008650605,
-0.014297526,
-0.018289085,
0.0038480505,
0.0011555832,
-0.045202076,
0.013309649,
-0.0019924424,
0.024923885,
0.028701851,
-0.014724717,
-0.0053732535,
0.008003144,
-0.011527464,
0.020932326,
-0.030277114,
0.012275048,
-0.00033019643,
0.0103593655,
-0.008570506,
-0.0009611783,
-0.030010121,
0.0055301124,
0.0054433392,
-0.021012424,
-0.008416984,
-0.022854682,
-0.009758629,
-0.012642164,
0.009625132,
0.0077628493,
0.029903322,
0.02473699,
0.017367957,
0.018689577,
0.002504737,
0.010018948,
-0.029502831,
-0.0045388974,
0.0047057685,
-0.030944599,
0.004048296,
0.0121816,
-0.037272356,
0.00020639885,
0.017181061,
-0.013923734,
-0.016967466,
-0.017528154,
0.017608251,
-0.026045261,
-0.014924962,
-0.010199169,
0.0062176217,
-0.02300153,
-0.026472451,
0.052491013,
0.010873329,
0.009211292,
-0.021119222,
0.005470039,
-0.0056435848,
-0.007882996,
0.007482506,
0.010432789,
0.0048626275,
-0.0113806175,
-0.0057437075,
-0.013650066,
-0.0015193624,
0.022080401,
0.022267297,
-0.010466163,
0.025324376,
-0.012201624,
-0.017528154,
-0.03139849,
0.008256788,
0.018208988,
-0.008450359,
0.008216739,
-0.014417673,
0.002005792,
0.0012265035,
-0.044134103,
-0.0039515104,
-0.0049260384,
-0.0052430937,
0.007482506,
0.003415854,
0.0019757552,
0.0029552893,
-0.01148074,
-0.004922701,
0.023028228,
-0.014030532,
0.023041578,
0.027233383,
0.005990677,
0.004495511,
-0.030837802,
0.0029552893,
0.0024680253,
-0.009324764,
-0.02034494,
0.0039748726,
-0.0011447365,
-0.013710139,
0.003392492,
0.004709106,
-0.028915446,
-0.0019373749,
-0.045308873,
0.030090218,
0.0025848353,
-0.031238293,
-0.013229551,
0.033294145,
-0.022334045,
0.009551709,
0.0033607865,
-0.16724502,
0.020131344,
0.00004218713,
-0.010132421,
0.007629352,
0.012555391,
-0.001255706,
0.0088708745,
-0.0071687875,
0.012728937,
0.033347547,
-0.0003840124,
-0.036818467,
-0.009091144,
-0.0038814247,
-0.011033526,
-0.011560839,
0.007155438,
0.0154456,
-0.007415757,
0.025297677,
-0.03356114,
0.009358138,
-0.008730702,
-0.0027283444,
0.025110781,
0.0026282219,
0.03588399,
-0.009705231,
-0.0059105786,
-0.021025775,
0.014297526,
0.00908447,
-0.023588916,
0.002312835,
-0.005369916,
-0.022080401,
-0.0012064789,
-0.009104494,
0.005329867,
0.014431023,
0.006861745,
-0.005920591,
0.013790238,
-0.018195638,
0.02426975,
0.015619147,
0.0103593655,
0.0308912,
0.004498848,
0.013603342,
-0.012054777,
0.011634261,
0.013543269,
-0.006481278,
-0.00043636825,
0.013142778,
0.01636673,
-0.038740825,
-0.020238142,
0.0132429,
-0.036818467,
0.0442409,
-0.015579097,
-0.0024263076,
-0.018422583,
0.0031088109,
-0.00038609828,
-0.025484573,
0.006044076,
-0.008944297,
0.011520789,
-0.017861895,
-0.0068550697,
0.0124018695,
0.0067716343,
0.008623905,
-0.005553474,
0.008563831,
-0.002823461,
-0.013977134,
0.010906703,
-0.033027153,
-0.010199169,
-0.01347652,
0.004245204,
0.010906703,
0.024216352,
0.0008994359,
-0.0061675604,
0.040449586,
-0.016433477,
-0.02469694,
-0.015752643,
0.012121526,
0.011267145,
0.0062476587,
-0.010392739,
0.00062534993,
-0.004071658,
0.0013449821,
-0.024977285,
-0.005630235,
0.0038246885,
0.04461469,
0.00088858925,
-0.021065824,
-0.014471073,
0.06140861,
-0.012548716,
-0.022080401,
-0.009785328,
0.010125746,
0.040956873,
-0.011400642,
0.04237194,
0.0013066017,
-0.019330362,
0.0037212283,
-0.0010938408,
0.03932821,
0.0076627266,
-0.012034752,
-0.016019637,
0.015712595,
-0.029129041,
-0.14449713,
-0.019490559,
-0.012668863,
-0.0022761235,
-0.01260879,
0.0088375,
-0.0133029735,
0.015806042,
0.0118144825,
0.023535518,
-0.0063477815,
-0.01347652,
0.0055868486,
-0.008063218,
0.004608983,
0.02254764,
0.009271366,
-0.008570506,
-0.020718731,
0.020064596,
-0.009571733,
0.012188274,
0.020531835,
0.0016895712,
0.012655513,
-0.004835928,
-0.013062679,
0.031051397,
0.013236226,
0.022507591,
0.0013149453,
-0.016460177,
0.0013324667,
-0.020451738,
0.018222338,
-0.0057503823,
-0.0019724178,
-0.015298754,
0.01501841,
-0.027500378,
-0.0012773992,
0.011460716,
0.019317012,
0.0011856201,
0.025831666,
-0.013910385,
0.0016820619,
0.019597357,
0.005757057,
-0.006825033,
-0.035002906,
-0.020932326,
-0.030811103,
-0.02473699,
0.027954267,
-0.020358289,
0.0027600501,
0.031745583,
-0.017154362,
-0.006754947,
0.018048791,
-0.0042819157,
-0.02693969,
0.0051863575,
0.0097719785,
-0.02161316,
-0.017141012,
-0.027220033,
0.017835196,
-0.050568655,
-0.011981354,
0.009631807,
0.0113205435,
0.01058631,
-0.024029456,
0.0053165173,
-0.011073574,
-0.022721186,
0.004135069,
-0.019343711,
0.005717008,
-0.023895958,
0.009144543,
-0.021452965,
0.0083769355,
-0.0012765649,
-0.006588076,
0.010392739,
0.0018455958,
-0.025738217,
-0.013923734,
0.02565812,
0.0129291825,
-0.033748034,
-0.021145921,
0.02607196,
-0.017568203,
-0.004979437,
0.020184742,
-0.015245355,
-0.0060741124,
-0.002633228,
-0.035536896,
0.020785479,
0.013623367,
-0.010499537,
0.011193722,
0.0132429,
0.004568934,
-0.0021426266,
-0.0047124433,
0.008924273,
-0.02029154,
0.020091295,
-0.009985574,
-0.027086537,
-0.029102342,
-0.04277243,
0.028621752,
-0.00684172,
0.014204078,
0.007582628,
-0.0077094506,
0.011420666,
0.0021326141,
0.025084082,
-0.015325453,
0.011073574,
-0.031985875,
0.03486941,
-0.034095127,
-0.033320844,
0.01457787,
-0.031585384,
0.008109941,
-0.012081477,
-0.013336348,
0.0128357345,
-0.014751416,
0.017314559,
0.014310876,
0.024443297,
-0.004275241,
-0.028968845,
0.006754947,
-0.015045109,
-0.0012365158,
-0.006524665,
-0.03938161,
0.023068277,
-0.006487953,
0.016246581,
0.023348622,
0.024096204,
-0.004181793,
-0.03396163,
0.0049727624,
-0.031558685,
-0.019610707,
0.0027600501,
-0.02385591,
-0.020425038,
0.03209267,
0.012695563,
0.026619298,
0.012448593,
-0.016473528,
-0.032146074,
-0.022694487,
-0.00926469,
-0.015712595,
-0.0663213,
-0.012214974,
-0.008643929,
0.015085159,
0.0119079305,
0.023909308,
0.0006403683,
0.0011889575,
0.021466315,
-0.0026165408,
0.019050019,
0.0028101115,
-0.013042655,
-0.017781798,
0.013963784,
0.046964236,
0.005356566,
0.012675538,
0.0064111925,
-0.005833818,
-0.004098357,
0.02115927,
0.026752794,
-0.0011672642,
-0.0243632,
0.026792843,
0.04106367,
-0.0023178414,
-0.008917598,
-0.0119079305,
0.0040082466,
0.011440691,
0.004679069,
-0.016820619,
-0.028648451,
0.0031688844,
0.021986952,
-0.010546261,
-0.007949745,
-0.00839696,
0.041837953,
-0.009738605,
0.009237991,
-0.008530457,
-0.0029653017,
-0.00673826,
0.013643391,
-0.03492281,
-0.0017012521,
-0.0044087376,
0.024750339,
0.010492862,
0.00016238655,
0.0009636813,
0.008623905,
0.014310876,
0.0046189954,
0.03308055,
-0.017701698,
0.031612083,
-0.014417673,
0.0031738908,
0.007288935,
-0.030223716,
-0.035189804,
0.0035910688,
0.013636717,
0.011000151,
0.0021426266,
-0.026178757,
0.059539653,
0.006981892,
-0.03575049,
-0.0004680738,
-0.00026699397,
0.047044337,
0.020798828,
0.016820619,
0.013503219,
-0.015218656,
0.017501453,
0.007462481,
0.012942532,
-0.033374246,
-0.013176152,
0.019303663,
-0.015178607,
0.0022544302,
0.0042118295,
-0.0061775725,
0.003624443,
-0.016740521,
0.013136103,
0.00518302,
-0.008704003,
-0.006541352,
0.041277267,
-0.005887217,
0.0021309454,
-0.029689727,
-0.018542731,
-0.005536787,
-0.031531986,
-0.014003833,
0.011534139,
0.020972375,
-0.014657969,
-0.007889671,
0.02915574,
0.015272054,
-0.008543807,
-0.021105872,
-0.01457787,
-0.036818467,
-0.007122064,
-0.0069485176,
0.028648451,
-0.02342872,
0.006618113
] |
Small non-coding microRNAs (miRNAs) contribute to cancer development and progression, and are differentially expressed in normal tissues and cancers. However, the specific role of miRNAs in the metastatic process is still unknown. To seek a specific miRNA expression signature characterizing the metastatic phenotype of solid tumours, we performed a miRNA microarray analysis on 43 paired primary tumours (ten colon, ten bladder, 13 breast, and ten lung cancers) and one of their related metastatic lymph nodes. We identified a metastatic cancer miRNA signature comprising 15 overexpressed and 17 underexpress | [
-0.03529261,
-0.024897145,
0.004538271,
-0.044024803,
-0.007374285,
0.0042621414,
-0.028743466,
0.0077901036,
-0.036747977,
-0.0051425076,
0.013696028,
0.006396461,
0.0046747117,
-0.008628238,
-0.01862088,
0.014761563,
0.021063816,
-0.00043612235,
0.0036091763,
-0.001569878,
-0.038931023,
0.013221735,
-0.012143205,
-0.016450828,
-0.008985582,
0.027340079,
0.014852524,
-0.03282369,
0.0077186343,
-0.028535558,
0.01864687,
0.010362982,
-0.019920314,
-0.013501113,
-0.016918624,
0.007231347,
0.0020401105,
-0.007575697,
0.01729546,
-0.028223693,
0.0052854456,
-0.0023974546,
-0.011493488,
-0.011220608,
-0.014735575,
-0.00005456605,
0.01474857,
-0.00800451,
0.0025192765,
0.023493756,
0.01224716,
-0.0028879908,
-0.028925387,
-0.01424179,
-0.020933872,
0.004866378,
-0.0011759872,
0.033993177,
-0.006195049,
0.011772866,
-0.0039567747,
0.0048468867,
-0.025546862,
0.014384728,
-0.016151957,
0.0149824675,
-0.0072963187,
0.002366593,
0.020881895,
0.007439256,
0.025468895,
0.026404487,
-0.0015641929,
0.015931053,
0.01316326,
-0.030614652,
-0.017035572,
-0.0029757025,
-0.007985018,
-0.0045967456,
0.017204499,
0.0027807874,
-0.01532032,
0.00041155494,
0.019634439,
0.001425316,
0.008212419,
0.010889252,
0.0087127015,
0.0051522534,
0.023688672,
0.034123123,
0.010531908,
0.0087127015,
-0.02518302,
0.014267779,
-0.03219996,
0.03885306,
0.005545332,
-0.03667001,
-0.0085437745,
0.011461003,
-0.023402795,
-0.0060488624,
-0.030354764,
0.006623862,
0.017802238,
-0.014761563,
0.022818051,
-0.010414959,
-0.029990923,
0.027547989,
0.0072053582,
-0.021934437,
0.027418045,
-0.0020807178,
0.031082448,
0.0034434986,
-0.023103926,
-0.022493193,
0.013579079,
0.007010443,
0.012364109,
-0.03225194,
0.025260985,
-0.01098671,
0.00007466666,
-0.0066401046,
-0.006133326,
0.0047461805,
0.0108437715,
0.007933041,
0.017126532,
0.01979037,
-0.011480494,
-0.008420329,
-0.017373424,
-0.00058149645,
-0.022714097,
-0.03516267,
-0.0156191895,
0.036929898,
-0.0073807817,
-0.0019670173,
-0.014735575,
-0.0027190645,
0.01511241,
0.0028587535,
0.023506751,
-0.001051729,
-0.015047439,
-0.034175098,
0.004681209,
-0.019101672,
0.0010379225,
-0.008777672,
0.011181625,
0.018373989,
-0.015866082,
0.0013838966,
0.031316344,
0.004915107,
0.019634439,
0.029289229,
0.019322574,
0.019322574,
0.014254784,
-0.001575563,
-0.0052757,
-0.017880203,
0.01924461,
0.010622868,
-0.033421427,
0.019673422,
0.0050028185,
0.0049573383,
-0.010791794,
0.014566649,
-0.033109564,
-0.013864955,
-0.011753376,
0.032511823,
0.001825704,
-0.010161569,
-0.03201804,
0.0071014035,
0.012325126,
-0.0005116519,
-0.0024250676,
-0.026040645,
-0.010479931,
0.016294895,
0.021726526,
0.005278948,
-0.6341235,
-0.02392257,
0.009830214,
-0.022688108,
0.005896179,
0.01855591,
0.0055648237,
-0.020219184,
-0.024039518,
0.017711278,
-0.030562675,
0.010168066,
0.015515235,
-0.021063816,
-0.015853088,
-0.04293328,
-0.016840657,
-0.009362418,
0.011974279,
-0.0020238676,
-0.045324236,
0.020063251,
0.025247991,
0.022688108,
-0.025806747,
-0.00069966365,
0.023077937,
-0.0042394013,
0.0076146796,
0.027210135,
-0.030354764,
0.014436705,
-0.014072864,
-0.028665502,
0.045350228,
-0.005769484,
-0.0001775554,
0.02967906,
0.0019832603,
0.019829353,
0.005522592,
-0.0099796485,
0.01933557,
0.009986145,
-0.040308423,
0.022324266,
-0.0020076246,
-0.009992643,
0.0030959002,
-0.00610084,
-0.010713829,
0.019049695,
-0.048546832,
-0.01669772,
-0.0062892577,
-0.012019759,
0.031680185,
-0.01415083,
0.0051002763,
-0.0013400407,
-0.0055518295,
0.017685289,
-0.0059254165,
-0.013475125,
0.0019670173,
0.012994334,
-0.01687964,
-0.00015786085,
0.007003946,
0.032693744,
0.02263613,
0.041607857,
0.002371466,
0.012429081,
0.0300429,
0.05306886,
-0.0030422986,
0.01924461,
-0.0007638232,
0.0032924395,
0.014943484,
0.0017331194,
-0.04256944,
0.013786988,
0.025858724,
0.007276827,
-0.021323703,
0.0030796572,
0.020245172,
0.030900527,
0.0028392621,
0.0052074795,
-0.01424179,
-0.0433491,
-0.025936691,
0.025170024,
-0.0049183555,
0.024819179,
0.016398849,
-0.033655327,
-0.03628018,
-0.006156066,
0.016502805,
-0.0049963216,
0.007582194,
-0.017893199,
-0.03672199,
-0.007913549,
0.00999914,
-0.030354764,
0.012559024,
0.017503368,
-0.009394904,
-0.01676269,
-0.017048566,
-0.022675114,
-0.0032729479,
0.018503932,
0.005961151,
-0.033603348,
-0.0026817056,
-0.0037391197,
0.013410153,
-0.00658163,
0.015294331,
0.0040997122,
-0.006458184,
-0.0142937675,
0.00580197,
-0.010395467,
-0.0043271133,
-0.017217493,
0.005249711,
-0.02183048,
0.0016519048,
-0.017139526,
-0.003768357,
0.021453645,
-0.022285283,
-0.02311692,
-0.03490278,
-0.01612597,
0.01745139,
0.0049573383,
0.009414395,
-0.013449136,
-0.024143472,
-0.0128578935,
0.01921862,
0.0032079762,
-0.022441216,
-0.006286009,
0.0040607294,
0.010622868,
0.032225948,
0.001431001,
-0.010726823,
-0.020167207,
0.012091228,
-0.023597712,
-0.0190367,
0.022947995,
-0.008576261,
-0.019452518,
-0.0077316286,
-0.019738393,
-0.012071736,
0.016060997,
0.005181491,
-0.031550243,
-0.0013871451,
-0.009830214,
0.000056748693,
-0.008387843,
-0.0023259858,
0.0005193673,
-0.015073428,
0.0007508289,
-0.013903937,
-0.01933557,
0.010765806,
-0.0053926487,
0.004882621,
-0.0065978733,
0.03848922,
0.043115202,
0.047117457,
-0.013254221,
0.013579079,
0.022194322,
-0.026690362,
0.019114666,
-0.019270597,
0.028769456,
0.0077316286,
-0.024689235,
0.013644051,
0.020531047,
0.0026589655,
0.021570595,
0.008582758,
-0.021570595,
-0.005649287,
0.000907167,
-0.0045285253,
-0.004047735,
0.003339544,
-0.0087127015,
0.015931053,
0.0054088915,
0.025468895,
0.025494883,
-0.00814095,
-0.009284452,
0.012149703,
0.003969769,
0.0019605202,
-0.009323435,
-0.02125873,
-0.015853088,
-0.017256476,
0.011253093,
0.00495409,
0.0012255282,
-0.0022447712,
0.00034171037,
0.01843896,
-0.019842349,
-0.0042231586,
0.008283888,
0.011610437,
0.009284452,
0.009005073,
0.0025403923,
0.017139526,
-0.005918919,
0.0069519687,
-0.018114101,
0.023532739,
0.005694767,
-0.031082448,
0.013234729,
0.00028343892,
-0.007458748,
0.004814401,
-0.021570595,
0.020868901,
0.027340079,
-0.0039047974,
0.0018451954,
0.0034662387,
0.01337117,
-0.008556769,
0.00651341,
-0.0025972426,
-0.034253065,
0.0011906059,
0.008933605,
0.061385233,
0.003178739,
0.011941793,
-0.0065426473,
-0.0015260221,
-0.020167207,
0.0005599746,
0.024338389,
0.019075682,
0.014683598,
0.005717507,
0.004089967,
-0.019868337,
-0.009388407,
0.034383006,
-0.03729374,
0.015346308,
0.017776249,
0.015177382,
0.018309018,
0.015086422,
0.017802238,
-0.028327648,
-0.025819741,
0.022999972,
0.006874003,
-0.019374553,
-0.022792062,
-0.012675973,
0.0035604476,
0.0011808601,
-0.0005323616,
0.027651943,
0.019283593,
0.0055713207,
0.0051230164,
-0.0055063493,
-0.0026963244,
0.016216928,
-0.025806747,
0.017555345,
0.0059384108,
0.010460439,
-0.016593765,
-0.0048566326,
-0.022129351,
0.03240787,
0.012929362,
-0.010902246,
-0.0042621414,
-0.025131043,
0.0002905452,
-0.030666629,
-0.0026346012,
0.003082906,
-0.0073158103,
0.0024900392,
-0.004892367,
0.031368323,
0.0076341713,
0.025702793,
0.012383601,
-0.012006765,
-0.037189785,
-0.0018224553,
0.014904501,
0.031602222,
0.018205062,
-0.009888688,
0.0052529597,
0.008420329,
-0.00046617174,
-0.022947995,
-0.015333314,
0.02066099,
-0.014631621,
-0.010817783,
0.003651408,
-0.005311434,
0.0034012669,
0.007978521,
0.016424838,
-0.001491912,
-0.019985287,
-0.032225948,
-0.010837275,
0.0018874271,
0.013124278,
0.03214798,
0.044804465,
0.018360995,
-0.020076247,
0.010122586,
0.0022821298,
0.045194294,
-0.025676804,
-0.0014123217,
0.031082448,
0.00041013368,
0.009960157,
0.015593201,
0.0013229856,
0.013143769,
-0.006487421,
-0.0040737237,
-0.0032615778,
0.0005944908,
0.016372861,
0.017698282,
0.013306199,
-0.00005009925,
-0.012175691,
-0.00766016,
0.018088114,
0.011279082,
-0.020141218,
0.005759739,
-0.010531908,
-0.01194829,
-0.025260985,
0.021986414,
0.015489247,
-0.010246033,
-0.0018110853,
-0.013423148,
-0.026456464,
-0.0006152005,
-0.009031062,
0.008452814,
-0.012559024,
0.0063509806,
-0.01997229,
-0.015957043,
-0.013137272,
-0.015333314,
-0.019270597,
0.011681907,
-0.018893762,
-0.01843896,
0.0036416622,
0.016619753,
0.025533866,
-0.0016494683,
-0.013527102,
-0.005038553,
0.034071144,
0.0053244284,
-0.019374553,
0.015944049,
-0.028197706,
-0.0019036699,
-0.024273416,
-0.013618062,
-0.0116494205,
-0.019543478,
0.0052302196,
-0.017048566,
-0.0043953336,
0.0155022405,
-0.0005477924,
-0.0026410983,
0.014345745,
0.005071039,
0.011954787,
0.0026264798,
-0.0016527169,
0.010083604,
-0.019803366,
-0.024962116,
-0.03181013,
-0.022064378,
-0.03196606,
0.0022675113,
0.0061365743,
-0.012987837,
-0.017061561,
0.010233038,
-0.0250011,
0.013013826,
0.01798416,
0.031706177,
0.021388674,
-0.005844202,
0.010798291,
0.0125655215,
0.009843208,
0.008985582,
-0.00651341,
0.01091524,
0.009472869,
-0.0074782395,
0.013955915,
-0.009277955,
-0.02066099,
-0.033837248,
-0.009102531,
0.002928598,
0.051067732,
-0.012818911,
-0.024299406,
-0.015944049,
-0.0107852975,
0.012468063,
0.0034305041,
0.0056687784,
-0.019283593,
-0.027210135,
0.040880173,
0.0013091791,
-0.0148135405,
0.020959862,
-0.03207002,
0.0057662358,
0.017113538,
0.005041802,
0.0015877452,
0.007991515,
0.017620318,
-0.024871156,
-0.008192928,
-0.010772303,
-0.016385855,
0.004492791,
0.00027267798,
0.033057585,
0.015125405,
0.015723145,
-0.00903756,
0.03336945,
0.0067050764,
0.005139259,
-0.006614116,
0.00651341,
0.023155903,
0.01020705,
-0.005522592,
0.036072273,
0.0017899695,
0.0035507018,
-0.0069454717,
-0.007471742,
0.0036838937,
-0.031134425,
-0.015060433,
0.008654227,
-0.020284155,
-0.048728753,
-0.00023694357,
-0.0045675086,
0.019621445,
-0.045921978,
-0.018244045,
0.019920314,
-0.0070689176,
0.020622008,
-0.016294895,
0.016437832,
-0.001958896,
0.0027905332,
-0.007120895,
-0.0077251317,
-0.005967648,
0.00465522,
-0.006630359,
-0.022324266,
0.005759739,
-0.018984722,
0.008706204,
0.021388674,
-0.013345181,
0.00014913028,
0.00088686333,
-0.054680157,
0.010077106,
-0.0051522534,
-0.014514672,
-0.010544902,
-0.013020323,
-0.012416086,
-0.03414911,
0.004291379,
0.0070234374,
-0.005106773,
0.01930958,
-0.0024201947,
-0.020427093,
0.022870028,
-0.00045561383,
0.02713217,
-0.017204499,
0.011824844,
0.012078234,
-0.0144107165,
-0.01736043,
-0.010135581,
0.012701961,
-0.008673718,
0.039502777,
0.030120866,
-0.01112315,
0.012468063,
0.021011839,
-0.0030358012,
-0.00017105823,
-0.019764382,
0.01997229,
-0.00642245,
-0.00770564,
-0.018724836,
-0.006230783,
-0.039528765,
0.005905925,
-0.022766074,
-0.0033135551,
-0.008810159,
-0.00038008427,
-0.010850269,
0.026430476,
-0.0076016854,
0.01784122,
-0.016151957,
-0.022675114,
-0.01591806,
-0.014774558,
-0.008972588,
-0.009128519,
0.004323865,
0.032225948,
0.0020774691,
-0.001051729,
0.0121562,
0.0034987244,
-0.01155846,
-0.015645178,
-0.002873372,
0.039840627,
-0.0054803602,
0.0039665205,
0.0052821967,
0.013994898,
0.028041773,
0.011149139,
0.005200982,
-0.023467768,
-0.022285283,
0.00014669386,
0.027807875,
0.02772991,
-0.007848578,
-0.0054121404,
-0.023012966,
0.0070624207,
-0.022766074,
-0.021804493,
0.0033980184,
-0.035370577,
-0.024910139,
-0.0010882755,
0.026105618,
0.03495476,
0.016931618,
-0.0005075912,
-0.026274543,
0.040074527,
-0.0045512654,
0.02949714,
0.0016380983,
-0.013566085,
-0.012364109,
0.0111881215,
-0.0149824675,
-0.033109564,
0.016359868,
-0.044310678,
-0.020258168,
0.0045675086,
-0.0026232312,
0.0049800784,
0.019595455,
-0.017711278,
0.004483045,
0.020193195,
0.000395312,
-0.0010224917,
0.004281633,
0.033447415,
-0.03667001,
0.0033882726,
0.0023373559,
0.019257603,
-0.0113050705,
-0.022272289,
-0.0026427228,
-0.0011118277,
-0.006441941,
-0.019153649,
-0.012006765,
0.021934437,
-0.014644614,
-0.011090664,
0.0037423682,
-0.0029935697,
-0.010356484,
0.029886968,
0.0050450503,
-0.0033947697,
-0.004408328,
0.012312132,
0.014969473,
0.0075951885,
-0.025897708,
-0.007504228,
-0.0049703326,
-0.014228796,
-0.024546297,
0.00067936,
-0.032615777,
0.027599966,
0.0034077642,
-0.00960931,
-0.02515703,
-0.007114398,
-0.041477915,
-0.036955886,
0.024793189,
0.01924461,
0.0029188523,
0.015060433,
-0.0024786692,
0.0026134856,
0.001364405,
-0.0019296586,
-0.012097725,
-0.015203371,
-0.008849141,
0.0032550807,
0.017971164,
0.0016795177,
-0.025988668,
-0.009914677,
0.030198833,
0.0063737207,
-0.028223693,
0.018542916,
-0.03511069,
0.006828523,
-0.022999972,
-0.0034499958,
-0.005918919,
0.01320874,
0.042595427,
-0.029237252,
-0.0059026764,
0.013657046,
-0.010512416,
-0.001541453,
0.016203934,
0.0034207585,
0.03495476,
-0.009531344,
-0.0022074126,
-0.036955886,
0.0094598755,
0.0032274676,
0.007341799,
0.032044027,
0.016905628,
0.03414911,
0.0037033851,
0.002204164,
-0.015853088,
-0.010031626,
-0.0035442046,
-0.0009364042,
0.012390098,
0.012812413,
-0.02713217,
0.002639474,
-0.01921862,
-0.007419765,
-0.0053081857,
0.0012198432,
-0.0104409475,
-0.011181625,
-0.0012856269,
0.0017412407,
-0.018166078,
0.008361854,
0.007302816,
-0.028171716,
-0.025247991,
-0.0046747117,
-0.011383037,
-0.02515703,
0.0053634113,
-0.017490374,
-0.0048403894,
-0.0018874271,
0.009934168,
-0.025299968,
-0.0037423682,
0.01181185,
0.18982123,
-0.015346308,
0.0020644749,
0.014722581,
0.007140387,
-0.01802314,
0.033889223,
0.011740381,
-0.0042134128,
0.0029578353,
0.01979037,
0.0069454717,
-0.015762128,
0.0039047974,
0.0217915,
-0.018698847,
-0.01089575,
-0.013345181,
-0.011155636,
0.0037456169,
-0.019465512,
-0.0113050705,
0.0081994245,
-0.005886433,
0.0059254165,
0.010967218,
-0.02066099,
0.0051977336,
0.02194743,
-0.0053764055,
-0.03568244,
0.006731065,
-0.0041776784,
0.00024567413,
0.008212419,
0.0142937675,
-0.007868069,
0.009063548,
-0.013358176,
-0.019010711,
-0.0019312829,
0.010993207,
-0.006165812,
0.006698579,
0.018192068,
0.011928799,
-0.005139259,
-0.0008141762,
0.007842081,
-0.013091791,
-0.03724176,
0.012779928,
0.022558164,
0.013644051,
-0.011727386,
0.005155502,
0.010707331,
0.00095833215,
-0.005772733,
0.02488415,
0.0014732326,
-0.017763255,
-0.02197342,
0.0058149644,
-0.023246864,
0.03705984,
0.010583885,
0.013709023,
0.016892634,
0.00081823696,
0.0012125338,
-0.015229359,
-0.011480494,
-0.004934598,
-0.0067570535,
-0.025819741,
0.02419545,
0.017087549,
0.0026410983,
0.029393183,
0.011272585,
-0.016515799,
-0.05195135,
-0.005415389,
-0.014943484,
-0.031498265,
0.012253657,
0.012838402,
-0.007913549,
-0.0036806453,
0.014956479,
-0.046155874,
-0.008823153,
0.0013993273,
0.022116357,
0.011162133,
-0.005265954,
0.014254784,
-0.011792358,
-0.034850806,
-0.032173973,
0.069025904,
0.0059579024,
0.017100545,
0.003908046,
-0.0015024699,
-0.00892061,
0.002538768,
-0.0059643993,
0.009706767,
0.0048533836,
-0.02146664,
0.010759309,
-0.013241227,
0.0046064914,
0.03295363,
0.014878512,
-0.021336697,
0.01882879,
-0.012877385,
-0.002087215,
-0.016112974,
0.021505622,
0.021336697,
-0.024871156,
0.014865519,
-0.020245172,
0.008121459,
0.0021700538,
-0.027496012,
0.006698579,
-0.012305634,
0.004249147,
0.006324992,
-0.0037033851,
-0.024143472,
0.02437737,
-0.0032696994,
-0.0020644749,
0.0022350254,
-0.0049086097,
0.003501973,
-0.01493049,
0.024039518,
-0.00052748877,
-0.0044797966,
0.027755897,
0.009375412,
-0.012162697,
-0.029289229,
-0.014969473,
-0.0021391923,
-0.00653615,
-0.0029659567,
0.03516267,
0.00018973758,
-0.032121994,
-0.023649689,
0.00050921546,
0.012578515,
-0.04919655,
0.004034741,
0.017711278,
-0.0116494205,
-0.005568072,
0.0076796515,
-0.16175348,
0.010291513,
0.026378497,
-0.027470022,
0.02305195,
0.0065458957,
-0.011909307,
-0.017971164,
0.008745187,
0.0054186373,
0.037137806,
-0.010850269,
-0.031524256,
-0.0047884122,
0.00814095,
0.016918624,
0.0031023973,
0.03459092,
0.03492877,
0.013098289,
0.02440336,
-0.018919751,
0.010109592,
-0.01619094,
0.0005392649,
0.0049508414,
0.0053796545,
-0.0041906727,
-0.019452518,
-0.0030959002,
-0.00692598,
-0.006692082,
0.007933041,
-0.004226407,
0.043037236,
0.035396565,
-0.012870888,
0.0067050764,
-0.010947727,
-0.0024965364,
0.022973983,
0.03064064,
-0.0014683597,
0.011370042,
-0.0031819877,
0.02377963,
0.007939538,
-0.008420329,
0.014865519,
0.0024510564,
0.009550836,
-0.0047559263,
0.023675676,
0.005350417,
0.012669476,
0.019166643,
0.025637822,
0.014254784,
0.0051522534,
-0.0047689206,
-0.0020011275,
-0.010304507,
0.020492066,
-0.0009891937,
0.010479931,
-0.020738957,
0.0080824755,
0.024507314,
-0.023727654,
-0.001119137,
-0.029315218,
-0.012727951,
0.014891507,
0.0011930423,
0.019712405,
0.023363814,
-0.0055355863,
0.01747738,
-0.013254221,
0.005360163,
-0.028379627,
0.0070559233,
-0.017750261,
0.0077966005,
0.015970036,
0.0064484384,
0.013670039,
0.0035994307,
-0.0017867209,
-0.011746878,
0.012851397,
-0.0043303617,
0.019257603,
-0.011486991,
0.00007431135,
0.024637258,
-0.0058831847,
-0.0074327593,
-0.009414395,
-0.012149703,
0.031498265,
-0.03492877,
-0.009063548,
0.021752516,
0.008582758,
0.0115909465,
-0.01025253,
0.00047104462,
0.037969444,
-0.013150266,
-0.017737266,
-0.0068610082,
0.012364109,
0.0045837513,
-0.0062210374,
0.04584401,
0.008478803,
-0.006178806,
-0.014943484,
-0.030016912,
0.05987789,
-0.008582758,
0.012110719,
0.018932745,
0.01855591,
-0.037735548,
-0.13597271,
-0.02509206,
0.018906755,
0.0071014035,
-0.030120866,
0.05015813,
-0.012611002,
0.024156468,
-0.028145729,
0.030926514,
-0.018127097,
-0.017971164,
-0.013696028,
0.0039990065,
-0.012266652,
-0.007783606,
0.0055908123,
-0.011058179,
-0.017438397,
0.047351353,
0.01091524,
0.002399079,
-0.0013384164,
-0.016022014,
0.0300429,
-0.010109592,
-0.02392257,
-0.01034349,
0.01474857,
-0.012909871,
0.013384164,
0.010421456,
0.021934437,
-0.010616371,
-0.018815795,
0.0002678051,
0.00032993426,
-0.013293204,
0.024806185,
0.0026346012,
-0.0025956181,
0.02050506,
-0.0073353015,
0.0023584717,
-0.0026199827,
-0.01059688,
-0.025975674,
0.014943484,
0.018101107,
-0.030536685,
-0.024689235,
-0.025234997,
-0.024806185,
-0.028249683,
0.007738126,
-0.01921862,
0.012260154,
0.019673422,
-0.027392056,
-0.009823716,
-0.0075497082,
-0.017048566,
0.0007853451,
0.028561547,
-0.0027353074,
-0.007257336,
0.0043011247,
-0.010395467,
0.015177382,
-0.021089803,
-0.0138909435,
0.0015552593,
-0.0076146796,
-0.023493756,
-0.024793189,
0.0051619993,
-0.011662415,
-0.038593173,
0.01034349,
-0.036566056,
-0.01346213,
-0.027859852,
0.025676804,
-0.0288994,
0.048884686,
0.022155339,
0.013410153,
-0.007868069,
0.012409589,
-0.01059688,
0.008686712,
0.04937847,
-0.013397158,
-0.030276798,
0.00834886,
0.0058149644,
0.0217915,
-0.007244341,
0.0070169405,
0.0087127015,
-0.009323435,
-0.02185647,
-0.046701636,
0.014800547,
-0.011805353,
-0.01738642,
0.032901656,
-0.027028214,
-0.010928235,
-0.0080824755,
0.0046909545,
0.04075023,
-0.010817783,
0.0044245706,
-0.0029708296,
0.0034824815,
-0.013683034,
0.01814009,
0.014995461,
0.00056606566,
0.01224716,
0.024572287,
-0.009882191,
0.0092909485,
-0.009076542,
-0.0055583264,
-0.0070624207,
-0.02632652,
0.0052757,
0.027028214,
-0.02437737,
-0.013358176,
0.016619753,
-0.012559024,
-0.009018068,
-0.000924222,
-0.027833864,
-0.025403922,
0.007991515,
0.034512952,
0.019920314,
0.03025081,
0.007900556,
-0.03196606,
0.002311367,
0.014176819,
0.0037066338,
0.019114666,
-0.027599966,
-0.012688967,
-0.010473433,
0.012416086,
0.029783014,
0.004622734,
0.002749926,
-0.051795416,
-0.022389237,
-0.0017461136,
0.0041386955,
-0.01738642,
-0.022610141,
-0.0066401046,
0.023610706,
0.034383006,
-0.016151957,
0.01745139,
-0.003963272,
-0.0027044457,
-0.02119376,
0.005009316,
0.013825972,
-0.024390366,
-0.025546862,
-0.0068155285,
0.011370042,
-0.007673154,
0.03547453,
-0.016463822,
-0.028613525,
0.022350255,
0.0039567747,
0.030614652,
0.029263241,
0.017659301,
-0.0011223856,
0.0052594566,
0.023220874,
0.007458748,
-0.011272585,
0.029445162,
0.0007910301,
0.005223722,
0.0053894003,
0.017217493,
0.000050429182,
-0.004866378,
-0.006623862,
0.018373989,
-0.012572018,
0.012071736,
-0.021544605,
0.024364376,
-0.00043490413,
-0.0084853005,
-0.0006643353,
-0.014878512,
-0.008127956,
0.020544043,
-0.024247428,
-0.014904501,
-0.0050807847,
0.016424838,
0.0023081186,
0.009680779,
-0.01073332,
-0.0028425106,
-0.015086422,
0.007861572,
0.0034110127,
-0.015177382,
-0.012831905,
0.054888066,
0.012611002,
0.0029399681,
0.0012044123,
-0.0130852945,
-0.0008340738,
0.0033054338,
0.024754206,
-0.017607322,
0.020180201,
-0.0064256983,
0.021986414,
0.001958896,
-0.039528765,
0.004314119,
-0.0047364347,
-0.00830338,
0.017308453,
0.005873439,
-0.011350551,
0.08098069,
-0.0028132733,
-0.024728218,
0.0144497,
-0.026105618,
0.04433667,
0.03238188,
0.010804789,
-0.017308453,
-0.027599966,
0.006273015,
-0.023571722,
0.029705048,
-0.04433667,
-0.004625983,
0.016658736,
-0.006763551,
0.030172843,
-0.010356484,
-0.007770612,
0.011629929,
0.017282464,
0.0076146796,
0.020622008,
-0.034045156,
0.0010070609,
0.03705984,
0.009212983,
-0.0017737267,
-0.02185647,
0.017503368,
0.006614116,
-0.04566209,
0.0011102034,
0.032901656,
-0.002665463,
0.004765672,
-0.050677903,
0.021596583,
0.031160414,
0.014137835,
-0.0015511987,
-0.013384164,
-0.020206189,
-0.0019182885,
-0.008355357,
-0.0066336077,
-0.008842644,
-0.0020287405
] |
We created a visualization tool called Circos to facilitate the identification and analysis of similarities and differences arising from comparisons of genomes. Our tool is effective in displaying variation in genome structure and, generally, any other kind of positional relationships between genomic intervals. Such data are routinely produced by sequence alignments, hybridization arrays, genome mapping, and genotyping studies. Circos uses a circular ideogram layout to facilitate the display of relationships between pairs of positions by the use of ribbons, which encode the position, size, and orientation of related genomic elements. Circos is capable of displaying data as scatter, line, and histogram plots, heat maps, tiles | [
-0.028911373,
-0.0022277366,
0.005235945,
-0.013743082,
-0.010580476,
0.003128672,
-0.0060028424,
-0.0036037415,
0.00089330034,
-0.020142946,
-0.0006379505,
-0.009637124,
-0.0064745187,
-0.000007933289,
0.016410258,
0.036512487,
0.017075356,
0.01061441,
0.000010902474,
-0.007994741,
-0.03287481,
0.0150529165,
-0.014238512,
-0.015677294,
-0.021269541,
0.02714683,
0.012745436,
-0.023522727,
0.0075671785,
-0.008741279,
0.03056733,
0.016885327,
-0.013118705,
-0.028911373,
-0.03740833,
-0.0042959857,
0.02576234,
0.003973617,
0.017048208,
-0.018215522,
0.01055333,
0.012066766,
-0.009365656,
-0.0044792267,
-0.017604718,
-0.0049780495,
-0.0026773561,
-0.015351532,
-0.017672585,
0.019219955,
0.010376875,
0.016383111,
-0.025178684,
-0.010118981,
0.020183668,
-0.00773006,
0.016355965,
-0.008205129,
0.000005510886,
-0.026264558,
-0.010173274,
-0.012121059,
-0.0113677345,
-0.010838372,
-0.016233804,
-0.033336308,
-0.010390448,
0.015134357,
0.018514138,
-0.0064914855,
0.057334103,
0.048674263,
0.0083272895,
0.020129373,
0.015324385,
-0.008483384,
-0.026495306,
-0.009990033,
0.008218703,
0.017957628,
0.01836483,
-0.011082693,
0.034205005,
-0.008211915,
0.0042925924,
0.02122882,
-0.005809421,
0.035969548,
-0.01597591,
-0.014197792,
0.012195713,
0.024825776,
0.01586732,
-0.0061080367,
-0.000809739,
0.008415517,
0.0113677345,
0.011238787,
0.0037191156,
-0.021079512,
-0.005911222,
0.005700834,
-0.024119958,
-0.01172743,
-0.021459568,
-0.030241568,
0.03056733,
-0.02397065,
0.009861086,
-0.010946959,
-0.012480754,
0.03955293,
-0.010587263,
-0.008870226,
0.020237962,
-0.017713306,
0.03784268,
-0.00001069039,
-0.0051477174,
0.004136498,
0.024893641,
0.016844608,
0.01385167,
-0.031218853,
0.01554156,
0.009576044,
-0.011632416,
-0.013865243,
-0.010180061,
-0.025178684,
0.000947594,
-0.0013047445,
0.0019121547,
0.019152088,
-0.014469259,
0.0028334502,
0.028096968,
-0.0070174555,
-0.018039068,
-0.013675215,
-0.0014056967,
0.020224387,
-0.0135462675,
-0.010702637,
0.0014328436,
0.03879282,
0.008551251,
0.022749042,
-0.0010824798,
-0.023006938,
0.032060403,
0.00046361695,
0.012073552,
-0.0011274418,
0.0035358744,
0.016559565,
-0.014238512,
0.008171195,
-0.0066916933,
0.012148206,
-0.0066916933,
0.009338509,
0.0008377342,
0.022572588,
0.020536575,
0.02456788,
0.005422579,
-0.025993088,
-0.0042756256,
-0.019790038,
0.00337978,
0.010784077,
-0.03800556,
0.026305277,
-0.020685883,
0.008551251,
-0.005758521,
0.021513863,
-0.024635747,
-0.02388921,
0.0067901006,
0.009114548,
0.021378128,
0.009833938,
-0.027526885,
-0.020020787,
0.03423215,
0.0071735494,
-0.0013200146,
-0.022450428,
0.0040346975,
0.0027791567,
0.0051578977,
0.002326144,
-0.635453,
0.0068851146,
0.014537127,
-0.047126897,
0.027934087,
0.005846748,
0.005826388,
0.014767875,
-0.007825074,
0.018310536,
0.010254715,
0.00039426528,
0.025246551,
-0.0014752605,
-0.051606122,
-0.048049886,
0.010051114,
-0.016233804,
0.024255691,
0.018242668,
-0.018459843,
-0.0038141294,
0.014700008,
0.0005679626,
0.009895019,
0.02106594,
0.034856528,
-0.020265108,
0.016152363,
0.02842273,
-0.016437406,
-0.007689339,
-0.0079608075,
-0.013627708,
0.04389642,
-0.008530891,
0.0015236158,
0.01745541,
0.009766072,
0.024214972,
-0.02285763,
-0.0028639904,
0.044059303,
0.019830758,
-0.013179786,
0.02739115,
0.0001336133,
-0.034313593,
0.002903014,
-0.02603381,
-0.010526183,
-0.017197516,
-0.008374797,
0.011476322,
0.020658737,
-0.009426736,
0.03143603,
-0.025870929,
0.024757909,
-0.0035053343,
-0.009800006,
-0.021255966,
-0.016545992,
-0.028748492,
-0.015283665,
0.020536575,
-0.016912475,
-0.000084091545,
0.020156521,
-0.004709975,
0.030377302,
0.019627158,
-0.0076146857,
-0.011530615,
0.0030166914,
0.044466507,
0.011998898,
0.018473417,
0.003963437,
-0.012602915,
0.0057245875,
-0.0024177644,
-0.01784904,
-0.004509767,
0.021052366,
0.011035186,
-0.013172999,
0.014496407,
0.0070581757,
-0.00886344,
0.008381584,
-0.009698205,
-0.01900278,
-0.044900857,
0.0026688727,
0.014550701,
0.0027604932,
0.014143498,
0.016464552,
-0.018609151,
-0.017618293,
-0.017957628,
-0.006820641,
0.01065513,
-0.016668154,
0.018568432,
-0.010682277,
0.015283665,
0.02778478,
-0.010811225,
-0.019043501,
-0.013098345,
0.002735043,
0.0044860137,
0.01108948,
-0.03092024,
0.016152363,
0.022966217,
-0.016885327,
-0.009820365,
0.012908317,
-0.009053468,
-0.004058451,
-0.015107211,
0.03697398,
-0.006830821,
0.0019070647,
-0.020210814,
-0.020400843,
-0.020563724,
-0.016070923,
0.008456238,
0.011822444,
0.0049101827,
-0.0049848366,
0.010105407,
0.017428264,
-0.003091345,
-0.022586161,
-0.03176179,
-0.018473417,
-0.0056363605,
-0.024201399,
-0.00061504537,
-0.015256518,
0.0069122612,
-0.034476474,
0.00664758,
0.022559015,
-0.011442388,
-0.0052732714,
-0.0125079015,
-0.027268989,
0.007804713,
0.017034635,
0.0040177307,
-0.004950903,
-0.026929654,
-0.021717463,
-0.036675368,
0.010926599,
0.0020427988,
-0.0100579,
-0.0040448774,
-0.0078115,
-0.021255966,
-0.011198067,
-0.0002990393,
-0.010275075,
-0.013553054,
0.030024393,
0.0019885052,
-0.031028826,
0.030350154,
0.0040889913,
0.02508367,
-0.0059519424,
0.004954296,
-0.015989482,
-0.010831585,
0.0061148233,
-0.008076182,
-0.020835191,
-0.02528727,
0.0047371215,
-0.0024075843,
0.017821893,
0.012731863,
-0.00083943084,
0.017984774,
0.0000065348568,
0.008856653,
-0.01852771,
0.008551251,
0.0034221972,
0.014347099,
-0.010838372,
0.02178533,
-0.011055546,
0.025803061,
0.038765673,
-0.0040652375,
-0.008680198,
-0.012826877,
0.024690041,
-0.032820515,
0.015297238,
-0.016722446,
0.0004504677,
-0.008320503,
0.016274525,
-0.009019534,
-0.0067290203,
0.002115756,
0.013105132,
0.0052155843,
-0.0026875362,
-0.00029182842,
0.0014006067,
0.006542386,
-0.01053297,
0.010600837,
0.034014978,
-0.010485463,
0.011014826,
0.003454434,
-0.008754852,
0.0104175955,
-0.010091834,
-0.024703614,
-0.0005009438,
0.02316982,
-0.011856377,
0.012555408,
0.028558465,
0.018269816,
0.034802236,
-0.012602915,
0.031490322,
0.0011741003,
0.0064711254,
0.016885327,
0.008218703,
-0.020156521,
0.032576196,
0.008089755,
0.01995292,
0.01698034,
-0.00830693,
0.0092774285,
-0.022287546,
-0.013485188,
-0.033526335,
0.0070649623,
0.0166953,
-0.013193359,
0.013729509,
0.0026010056,
0.031055972,
0.031924672,
0.010254715,
-0.0097592855,
0.006145363,
0.0051646843,
-0.019260675,
-0.0071464027,
0.0016924351,
-0.03168035,
-0.04272911,
0.01964073,
0.013763443,
-0.013159425,
0.012270367,
0.0023974043,
-0.018161228,
0.003932897,
-0.0056736874,
-0.00031494565,
0.028178409,
0.000752052,
-0.0028843505,
-0.038738526,
0.020156521,
0.0068240343,
0.006311638,
-0.0075943256,
-0.010410809,
-0.00502895,
0.0038446696,
0.012127846,
0.01892134,
-0.00015344321,
0.009874659,
-0.01057369,
-0.014062057,
0.004971263,
0.012915104,
-0.008551251,
-0.0046115676,
0.020835191,
-0.0033831736,
0.01554156,
0.004954296,
-0.017102502,
0.051606122,
0.007350004,
0.020020787,
-0.012005685,
-0.0029793645,
0.0037021488,
-0.013675215,
-0.019613585,
-0.0025263517,
-0.013071198,
-0.004693008,
0.011815657,
-0.013451254,
-0.011944605,
0.008232276,
0.010919812,
-0.009447097,
-0.05296346,
-0.0025551952,
0.0053682853,
0.038141295,
0.011272721,
-0.020427989,
-0.002572162,
-0.005453119,
-0.00010190665,
-0.049977314,
-0.016926048,
0.010784077,
-0.0041093514,
-0.031246,
-0.0036648219,
0.03396068,
-0.021513863,
-0.022273973,
0.032141846,
-0.010838372,
-0.024418572,
-0.02464932,
0.02516511,
-0.011971751,
-0.007940448,
-0.00014930755,
0.02186677,
0.0069020814,
-0.015826602,
0.03501941,
0.02564018,
-0.014659287,
-0.036702514,
-0.024214972,
0.028069822,
-0.00221586,
0.01764544,
-0.01892134,
0.02361774,
0.015623,
-0.008035461,
-0.002005472,
-0.0022430068,
0.016505271,
0.030757356,
0.013172999,
0.010166488,
-0.015134357,
0.011055546,
0.0027587966,
0.025965942,
-0.017672585,
-0.0020071687,
0.0027740665,
-0.020957353,
0.009684632,
-0.0046013873,
-0.0031337622,
-0.024500012,
-0.032901958,
-0.0044215396,
-0.019532144,
-0.0013030478,
-0.010784077,
0.0018120508,
-0.0040550577,
-0.030241568,
-0.0010010393,
-0.016749594,
-0.0051171775,
-0.039172873,
-0.034856528,
-0.0105058225,
-0.005025557,
-0.046583958,
-0.018120509,
-0.01106912,
0.020427989,
0.006074103,
0.026169544,
-0.019247102,
-0.0034849741,
0.006898688,
0.002431338,
-0.024160678,
0.0028521137,
-0.024554307,
-0.01117092,
0.0042349054,
-0.009304576,
-0.008992387,
-0.010784077,
0.013030478,
0.009331723,
-0.017821893,
0.019233529,
-0.01385167,
0.018296963,
0.04229476,
-0.004709975,
0.016858181,
0.0037937693,
-0.03577952,
0.011903885,
-0.040448774,
-0.0011902188,
-0.01176815,
0.005212191,
-0.0022565802,
-0.033607773,
0.00017454562,
-0.02623741,
-0.015853748,
0.0043706396,
-0.020957353,
0.009060254,
0.021459568,
0.023739902,
0.0083408635,
0.00071811845,
0.023875637,
-0.005025557,
-0.031870376,
-0.00026362116,
0.00498823,
-0.0047337282,
0.0016474732,
-0.028477024,
0.03577952,
-0.015378678,
-0.0055888533,
-0.009725352,
-0.008082968,
-0.0012309391,
0.029155694,
0.012446821,
-0.00675956,
-0.0040923846,
0.008001528,
0.007689339,
0.01741469,
-0.017563999,
-0.006830821,
-0.012630062,
0.005507413,
0.022165386,
-0.015337958,
-0.012643635,
-0.03374351,
-0.008843079,
0.015365105,
-0.010152914,
0.014564274,
0.0031982358,
0.004662468,
-0.017021062,
-0.038222734,
0.0014124834,
-0.025965942,
-0.019885052,
0.015432972,
0.042783402,
0.042756256,
0.03689254,
0.0040822043,
-0.00844945,
0.029182842,
0.008558038,
0.0013318913,
0.005171471,
-0.005880682,
-0.039661516,
-0.012663996,
0.0067731338,
0.01613879,
-0.02858561,
-0.0028622937,
0.013240865,
0.025667327,
-0.006457552,
-0.021391701,
0.006976735,
-0.03328201,
-0.023210539,
0.015297238,
0.003943077,
0.001341223,
-0.019545717,
0.002058069,
0.048429944,
0.0072210566,
0.038467057,
-0.006382898,
0.02316982,
0.019369263,
0.04348922,
-0.0025331385,
0.027879793,
-0.0011401668,
-0.01852771,
-0.04107315,
-0.011422029,
0.026508879,
0.008938094,
0.028314143,
0.009650698,
-0.009372443,
0.010349728,
0.02345486,
-0.019695025,
0.01570444,
0.037516918,
-0.012765796,
-0.003138852,
-0.021255966,
-0.021649595,
-0.008191556,
-0.0007673221,
0.0006956375,
-0.014930756,
0.013668428,
0.0035256944,
-0.010756931,
0.01729253,
0.02520583,
0.029047107,
-0.0013844883,
0.03254905,
-0.008680198,
-0.015718015,
-0.023183392,
0.0033696,
0.014034911,
-0.0044283266,
0.015948761,
0.013444467,
-0.014835742,
-0.0125961285,
0.0028809572,
-0.0013098345,
-0.022002505,
-0.05239338,
-0.011354161,
-0.013817736,
0.024812201,
-0.027404724,
0.015745161,
-0.030377302,
0.017211089,
-0.0033729936,
0.001937605,
0.0036817887,
-0.0063387845,
0.0029912412,
0.023047658,
-0.011903885,
0.036648218,
-0.02158173,
-0.019504996,
0.0021327226,
-0.008897373,
-0.020102227,
0.0055651,
0.026929654,
0.015758734,
-0.013193359,
0.0029776678,
0.01570444,
0.017713306,
0.015568706,
-0.013844883,
-0.033309158,
0.03879282,
-0.018649872,
-0.02055015,
-0.009297789,
-0.0027061994,
0.016803887,
0.018025495,
-0.003176179,
-0.023101952,
-0.0036682154,
0.0104175955,
0.022192532,
-0.014007764,
0.015948761,
-0.015161504,
0.012107486,
-0.005958729,
-0.03884711,
0.0050560967,
-0.0003857819,
-0.036946833,
-0.0074042976,
0.00783186,
0.004798202,
0.03792412,
0.014319953,
0.0036139216,
-0.007981168,
0.023834916,
-0.03662107,
0.03108312,
0.0076146857,
0.010919812,
-0.06922442,
0.005344532,
-0.025015803,
-0.02436428,
0.022884777,
-0.015337958,
-0.033716362,
-0.010946959,
0.008225489,
0.027255416,
0.009576044,
-0.026495306,
-0.0021938032,
0.0055243797,
0.010166488,
-0.018147655,
-0.051931884,
-0.0066747265,
-0.032033257,
-0.0050560967,
0.008544465,
-0.014374246,
0.0088091465,
-0.03979725,
-0.0012826876,
0.020699456,
-0.007282137,
-0.03311913,
-0.022233253,
-0.0029895445,
0.008734493,
0.012073552,
-0.022599734,
-0.010587263,
-0.02075375,
0.02158173,
0.019124942,
0.008978814,
0.006997095,
0.013451254,
0.003943077,
0.011788511,
-0.0006625523,
-0.012446821,
-0.004377426,
-0.016831035,
-0.043923568,
-0.022097519,
0.001168162,
0.022654029,
0.029318575,
-0.030974532,
-0.03235902,
-0.0026552991,
-0.03963437,
-0.029671485,
0.014808595,
0.009508177,
-0.009691418,
0.022626882,
0.012453608,
0.018256243,
-0.018690592,
0.0027995168,
0.014238512,
-0.0032847663,
0.024513587,
0.010566903,
0.017129648,
-0.0029912412,
-0.012609703,
-0.007635046,
-0.0013547965,
0.014509981,
-0.013770229,
0.020984499,
0.0068443944,
0.029264282,
-0.014998623,
0.010784077,
0.0076418323,
0.006074103,
0.009895019,
-0.005449726,
0.010675491,
-0.008714132,
-0.0053581055,
-0.011788511,
0.017034635,
-0.015229371,
-0.005290238,
0.019382836,
-0.019939346,
-0.013240865,
0.0037496558,
0.0007185426,
-0.009779645,
0.009935739,
0.00396683,
0.022966217,
0.018744886,
-0.0060130227,
-0.0059078285,
-0.008693772,
-0.010437956,
-0.0028843505,
0.01333588,
-0.012894744,
0.0017543639,
-0.0075332453,
0.026373144,
-0.010478676,
-0.0042552655,
0.017116075,
-0.008741279,
-0.015093637,
0.035562348,
0.0017212786,
0.019980066,
-0.0139127495,
-0.0067120534,
-0.013023691,
-0.016098069,
0.008564824,
0.00555492,
-0.025938796,
0.021391701,
0.0038921766,
-0.012453608,
-0.0050934236,
0.012548622,
0.017021062,
-0.023685608,
0.0021123625,
0.1754771,
-0.0003605438,
0.021798903,
0.033091985,
-0.0062437705,
-0.0038548496,
0.00445208,
-0.003417107,
0.011286294,
-0.00030921935,
-0.004933936,
-0.000752052,
-0.025993088,
0.0019257282,
0.017428264,
-0.027621899,
-0.012209286,
-0.024418572,
-0.023780622,
-0.0036478553,
0.035969548,
-0.0039600437,
-0.027676193,
-0.024554307,
0.017387545,
-0.0052257646,
-0.029019961,
-0.0040652375,
0.008890587,
0.018052641,
-0.021215247,
0.007899728,
-0.019179234,
-0.001514284,
-0.0036003483,
0.014781448,
0.013505547,
-0.007282137,
0.008062609,
0.0059180087,
-0.017183943,
-0.020129373,
0.009813579,
-0.01741469,
0.03157176,
0.007139616,
0.0054090056,
0.007818286,
-0.002987848,
0.0024584846,
-0.0168989,
0.015134357,
-0.0022922105,
0.041127447,
0.0057822745,
-0.0082390625,
0.022287546,
-0.010437956,
0.005083244,
0.03417786,
-0.016926048,
-0.00276728,
0.014374246,
-0.0040279105,
-0.021418849,
0.0068172473,
0.002960701,
0.030404449,
0.007397511,
0.0007041209,
0.0025178683,
-0.014306379,
-0.012032832,
-0.014781448,
-0.014645714,
-0.012121059,
0.05880003,
0.0128879575,
0.021459568,
0.01065513,
0.0071803364,
0.01180887,
-0.018772032,
0.013573415,
0.01550084,
-0.029807217,
0.0138380965,
0.008815933,
-0.009589617,
-0.003732689,
-0.007540032,
-0.009053468,
-0.016478125,
-0.016111642,
0.004279019,
0.0026111857,
-0.0021123625,
0.02592522,
-0.008171195,
0.0091892015,
-0.027486164,
0.047642685,
0.024581453,
0.0107976515,
-0.003449344,
0.00785222,
-0.01222286,
0.0027486165,
0.008211915,
0.0077029127,
0.013023691,
-0.026603892,
0.016301671,
0.0037937693,
-0.009046681,
0.022016078,
0.030078687,
-0.04745266,
0.01947785,
0.021093085,
-0.01642383,
-0.01125236,
-0.0055888533,
0.026373144,
-0.014048484,
-0.0021293294,
-0.019016353,
0.0074042976,
-0.011259147,
-0.004940723,
0.0058671082,
-0.027187549,
0.013675215,
0.0027503131,
0.0034137138,
-0.0038310962,
-0.0233327,
-0.00059765443,
-0.021283114,
-0.007940448,
-0.0055142,
0.0031931459,
-0.014170645,
0.0034306806,
0.004041484,
-0.021038793,
0.0024907216,
0.005154504,
0.0016126913,
-0.024160678,
-0.01642383,
0.0018493778,
0.021853197,
0.0009764375,
0.02392993,
-0.034965117,
0.007696126,
-0.053479254,
0.01613879,
-0.005962122,
-0.028205555,
0.0012801427,
0.02743187,
-0.0006850333,
-0.013003331,
0.006542386,
-0.17221949,
-0.021011645,
0.020726604,
-0.026250985,
0.004038091,
0.009528537,
0.027879793,
-0.0027520098,
0.023957077,
0.010743357,
0.0038989633,
0.014319953,
-0.0246086,
-0.00950139,
0.007071749,
0.018690592,
0.0053547123,
0.03295625,
0.01729253,
0.024377853,
0.028531317,
-0.0269568,
0.024119958,
-0.019437129,
0.020916631,
0.00017878732,
-0.02615597,
0.026658187,
0.009100975,
-0.031897523,
-0.023427714,
-0.0048524956,
0.010526183,
-0.029562896,
0.006783314,
-0.012073552,
-0.005507413,
0.0051103905,
0.0007041209,
-0.012901531,
0.020889485,
0.00666794,
-0.00043901513,
-0.016831035,
0.0074721645,
0.015555133,
-0.00014898943,
-0.018717738,
0.014523554,
0.015826602,
0.0077979267,
-0.0048898226,
0.04091027,
-0.008055821,
0.034014978,
0.0028707772,
0.015568706,
0.014672861,
0.016831035,
-0.011693496,
-0.018690592,
-0.034557912,
0.010899452,
-0.010085047,
-0.014564274,
0.0007876822,
-0.010431169,
0.008401943,
-0.0032949464,
0.011958178,
0.001784904,
0.004509767,
-0.0136480685,
-0.02075375,
0.021052366,
0.026685333,
-0.027106108,
0.018079787,
0.017143223,
-0.0028164836,
-0.011238787,
0.026088102,
-0.007078536,
-0.029155694,
0.01288117,
-0.01741469,
-0.0071260426,
0.011761364,
-0.030323008,
0.021364555,
0.008116902,
-0.018582005,
0.0046319277,
0.007445018,
0.028096968,
0.01995292,
0.008334077,
-0.017034635,
0.022206105,
-0.01788976,
0.0053004185,
0.01121164,
-0.018799178,
0.021093085,
0.030513035,
0.0049475096,
0.011571336,
0.0016025113,
0.041751824,
0.015772307,
-0.021907492,
-0.0027961235,
0.016545992,
0.021554582,
-0.0033322733,
0.020455135,
-0.017143223,
0.0053988257,
0.012046405,
-0.0125961285,
0.06835572,
-0.010763718,
-0.012908317,
-0.009141695,
-0.0062878844,
-0.0097592855,
-0.10820726,
-0.029427163,
0.0017187336,
0.013980617,
-0.01284045,
0.0062505575,
-0.00553456,
0.006983522,
0.0003414562,
0.040638804,
-0.03173464,
-0.0235363,
-0.027730485,
0.0046285344,
-0.020020787,
-0.011910671,
-0.042783402,
-0.004577634,
0.026101677,
0.015623,
-0.0038107361,
-0.029807217,
-0.010207208,
0.010913026,
0.0022226467,
-0.0025229584,
-0.0045233406,
0.009643911,
0.015894469,
0.03477509,
-0.0034680073,
-0.013220506,
-0.003186359,
-0.011347375,
-0.026074529,
-0.014034911,
0.0054463325,
-0.049868725,
0.009772859,
-0.02380777,
-0.010499036,
-0.008076182,
0.0065118456,
0.00277746,
0.021595303,
-0.0017662406,
0.0075468183,
0.02640029,
-0.0074993116,
-0.021649595,
-0.003909143,
-0.008069395,
-0.018907767,
-0.020251535,
0.015446546,
-0.005235945,
0.009338509,
-0.022911923,
-0.015283665,
0.005103604,
0.0065457793,
-0.0071599763,
-0.025789488,
0.04145321,
0.0060673165,
-0.013430893,
-0.03287481,
-0.012039619,
0.01634239,
-0.009406377,
-0.020780897,
0.027730485,
-0.021554582,
0.01546012,
-0.020319402,
-0.00611143,
-0.020970926,
0.000084250605,
0.027051816,
-0.023210539,
0.011618842,
-0.024391426,
0.039688665,
-0.013967044,
0.0042382986,
0.018799178,
-0.0029759712,
-0.010349728,
-0.00027358913,
-0.023862062,
0.0091892015,
0.0013208629,
0.010261501,
-0.011503469,
-0.018595578,
-0.012134633,
-0.01277937,
-0.024975082,
-0.018554857,
0.0060096295,
-0.040964566,
0.009521751,
-0.05581388,
0.019722171,
0.0083272895,
0.0062980643,
0.0044283266,
-0.029807217,
0.016559565,
0.00023605017,
0.0045369137,
0.0055209864,
-0.016274525,
0.020047933,
-0.024798628,
-0.003559628,
-0.027445445,
-0.038629938,
0.029400015,
0.01222286,
0.025870929,
0.012412888,
-0.0071599763,
0.0034697042,
0.018894194,
0.026861787,
-0.014564274,
-0.0019613584,
0.006016416,
0.024866495,
-0.018989207,
-0.016369538,
0.013980617,
-0.0053513185,
-0.003512121,
0.03173464,
0.006610253,
0.0007562937,
-0.013274799,
0.013865243,
0.027459018,
0.019111367,
-0.039525785,
-0.031055972,
0.018636297,
0.0211881,
-0.0026111857,
0.009888233,
-0.007485738,
-0.003065895,
-0.0051137838,
-0.0036444617,
0.014184218,
0.0074585914,
-0.0031490321,
-0.03879282,
0.0029929378,
-0.012501115,
0.014509981,
0.004547094,
0.01343768,
-0.026902508,
0.036485337,
0.030105833,
-0.00049118797,
0.00086318434,
-0.0127861565,
-0.028096968,
-0.022124665,
0.0008084665,
0.003983797,
-0.044330772,
-0.029915806,
0.021215247,
-0.0038514563,
-0.0033000363,
-0.0074382313,
-0.027825499,
0.005422579,
-0.00034887917,
0.023916356,
0.024975082,
0.0148628885,
-0.001900278,
-0.0016423832,
0.019803612,
0.027106108,
-0.012535049,
-0.0006672182,
0.007512885,
-0.0033509368,
0.010818011,
-0.009677844,
0.019830758,
0.010661917,
0.007092109,
-0.0006786707,
0.036919687,
-0.007987955,
0.011849591,
0.014252085,
0.020604443,
-0.008951667,
0.012568981,
-0.0006485547,
-0.009270642,
0.0007465378,
0.014740728,
-0.0052936315,
-0.02730971,
0.020142946,
0.017319677,
0.008028675,
-0.024214972,
-0.020713031,
-0.017957628,
-0.000014328966,
0.017740453,
0.009990033,
-0.0043502795,
-0.022789763,
0.00089754205,
0.030323008,
-0.0005081547,
-0.004377426,
0.0075468183,
0.011123413,
0.009854299,
0.03349919,
-0.034096416,
0.01725181,
-0.012277153,
0.015921615,
0.008008314,
-0.006104643,
-0.01385167,
-0.014903609,
-0.008381584,
0.02325126,
-0.018188376,
-0.020305827,
0.08355794,
-0.0047540884,
0.0066373996,
0.011754577,
-0.04118174,
0.032087553,
0.008089755,
0.004577634,
-0.01772688,
-0.039878692,
0.009487817,
-0.015487266,
-0.0063218176,
-0.017496131,
-0.007967594,
0.012311087,
-0.03662107,
0.0016135396,
-0.026821068,
0.0011223517,
0.002913194,
-0.018989207,
0.018785605,
0.0005386949,
-0.022097519,
-0.0018663445,
0.026223836,
0.0026111857,
-0.005979089,
-0.010125767,
0.005381859,
0.00020243475,
-0.03501941,
-0.0028996207,
-0.02102522,
0.005470086,
0.0034849741,
-0.0018629511,
0.018473417,
0.031870376,
0.024323558,
0.008571612,
-0.018215522,
-0.016790314,
-0.0028351468,
0.014971476,
0.006240377,
-0.023522727,
-0.030024393
] |
Platelet inhibitors are the mainstay treatment for patients with vascular diseases. The current 'gold standard' antiplatelet agent clopidogrel has several pharmacological and clinical limitations that have prompted the search for more effective platelet antagonists. The candidates include various blockers of the purinergic P2Y12 receptor such as prasugrel, an oral irreversible thienopyridine; two adenosine triphosphate analogues that bind reversibly to the P2Y12 receptor: ticagrelor (oral) and cangrelor (intravenous); elinogrel, a direct-acting reversible P2 | [
-0.023470728,
-0.009390963,
0.02976254,
-0.0110674435,
0.00054602505,
0.032567807,
-0.0110674435,
0.0029538786,
-0.03681578,
-0.0005660627,
0.010713446,
0.026663389,
0.0079015,
0.006395339,
-0.012536868,
-0.0013767512,
0.036308162,
-0.0076877656,
0.009290775,
-0.019516638,
-0.012289738,
0.026850406,
-0.019917391,
-0.014720969,
-0.006148209,
0.028346548,
0.009511189,
-0.030831212,
-0.010887105,
-0.008843268,
0.0015712831,
-0.0018217533,
0.0065890364,
-0.00008505551,
-0.00596787,
-0.039968364,
0.0039307126,
0.0012932612,
0.0015904858,
0.02580845,
0.017512877,
-0.009083719,
0.0128841875,
-0.012222946,
-0.009230662,
-0.006816129,
0.005840965,
0.01100733,
-0.041090474,
0.013291619,
0.0107935965,
-0.014199991,
0.022161603,
-0.005774173,
0.0050895545,
-0.026636671,
0.0036635443,
0.03724325,
-0.006238378,
-0.013972898,
-0.023163484,
-0.008302253,
-0.024793211,
0.014266783,
-0.004338144,
0.014694252,
-0.00090837193,
0.006482169,
0.022989824,
0.006759356,
0.026676746,
0.025928676,
0.011708647,
-0.016844956,
0.013231506,
-0.043414835,
-0.035025753,
-0.017726611,
-0.01076688,
0.020358218,
0.02202802,
-0.014280141,
-0.0023310427,
0.0027935777,
0.011915702,
0.005934474,
0.0071333917,
0.0067894123,
-0.016123602,
0.010439598,
0.017232351,
0.03422425,
0.011361329,
0.017860195,
-0.012156154,
0.033235725,
0.012596982,
0.012964338,
-0.008522666,
-0.019369695,
0.029922841,
-0.0028436717,
-0.0018417909,
-0.01639077,
-0.0270775,
0.010733483,
-0.03211362,
-0.020625386,
0.01832774,
0.009618056,
-0.02218832,
0.059364777,
0.006365283,
-0.036361594,
0.025661508,
-0.012009212,
0.020331502,
-0.0043648607,
0.008108555,
-0.017539594,
0.015949942,
-0.00029388504,
0.021306666,
-0.0077411993,
0.022174962,
-0.0146141015,
-0.00470884,
-0.005099573,
-0.0038238452,
0.0018701776,
-0.0031759623,
0.028346548,
-0.025487848,
-0.015348814,
-0.007807991,
0.01253019,
-0.010973935,
-0.015883151,
-0.018781926,
-0.034357835,
-0.011207707,
0.012323135,
-0.009484472,
-0.012991055,
0.0065957154,
0.015615982,
0.013852672,
0.002227515,
0.009805074,
0.009564622,
-0.00252307,
-0.025087096,
0.0024946833,
-0.02110629,
-0.017232351,
-0.00395075,
-0.021320025,
0.012710528,
-0.008435836,
0.0058810404,
0.008222102,
-0.022963108,
-0.00044541952,
-0.0064086975,
0.03203347,
0.019022377,
-0.017112125,
0.020371577,
-0.0057374374,
-0.0033229047,
-0.00007868939,
0.034010515,
-0.020211276,
-0.00058484793,
0.0032076885,
0.0008090188,
0.01681824,
0.0047255377,
-0.0124366805,
-0.011882307,
0.00000928827,
-0.014266783,
0.012176191,
0.019970825,
-0.0017833479,
0.02563479,
0.027838929,
-0.0055704573,
-0.013298298,
-0.026195845,
0.0092507,
0.027211083,
-0.0020989403,
-0.020371577,
-0.6459059,
-0.018594908,
0.014867911,
-0.019262828,
0.019957466,
0.030911364,
0.037376832,
-0.0137057295,
-0.017726611,
0.017873554,
0.011134235,
0.0011479885,
-0.0044683884,
0.0018134043,
-0.03254109,
-0.030724345,
-0.011414763,
-0.0121628335,
0.014747686,
0.0033479517,
-0.0101724295,
0.013972898,
-0.0042212578,
-0.007447314,
0.034331117,
-0.013585504,
0.006692564,
-0.011294536,
-0.018728493,
0.03943403,
-0.006605734,
0.05642593,
-0.017192274,
0.013772522,
0.051723767,
-0.004424974,
0.019610148,
0.0173125,
0.019142604,
0.026609955,
-0.0027117573,
0.022963108,
0.021747492,
-0.010833671,
0.0127973575,
0.0061582276,
0.013825956,
0.017686537,
-0.013211468,
0.018701775,
0.0023410616,
-0.0024262215,
-0.009464434,
0.006151548,
0.024272233,
0.015028212,
0.022829525,
-0.016190395,
0.008268856,
0.008829909,
-0.00065957155,
0.007954934,
-0.0031392265,
-0.027224442,
-0.0070398827,
0.008609496,
-0.025741657,
0.009551263,
0.014774403,
-0.0043414836,
0.0320869,
0.0010553144,
0.006702583,
-0.02781221,
0.020986063,
0.017940346,
0.018127363,
-0.00015195193,
-0.0171522,
-0.00053851097,
0.011648535,
0.018047214,
-0.024579477,
0.034918886,
0.0520978,
0.011668572,
-0.02026471,
-0.0048624617,
0.025020303,
-0.021039497,
0.00999877,
-0.0076944446,
-0.02757176,
-0.036789063,
-0.015682774,
0.03203347,
0.0025330887,
0.000054164182,
0.018781926,
-0.007380522,
-0.018180797,
-0.0052932706,
-0.011541667,
0.009865186,
0.020972705,
0.0048190467,
-0.04750251,
-0.0116151385,
0.02428559,
-0.034945603,
0.01773997,
-0.014146557,
-0.004254654,
0.0025314188,
0.01261034,
-0.01672473,
0.003354631,
-0.0030223406,
-0.022215037,
-0.04007523,
0.0022408734,
-0.0028169549,
-0.0012222946,
-0.0015579247,
0.0008582779,
-0.008135272,
0.0046286895,
0.0030206707,
0.006866223,
-0.02531419,
0.013264902,
0.0052097803,
0.025915317,
0.008669608,
0.026543163,
0.0010052205,
0.024860002,
0.01067337,
0.01470761,
-0.010646653,
-0.023470728,
-0.011207707,
-0.00018232144,
0.04036912,
0.0029471994,
-0.028480133,
0.005019423,
0.013318336,
-0.0075475024,
-0.009992091,
0.008536025,
0.0003051562,
-0.0023009863,
0.023256993,
0.013972898,
-0.005136309,
-0.0011070783,
-0.027384743,
-0.024125291,
-0.021814285,
0.012617019,
-0.015909867,
0.0064754896,
-0.0063686226,
-0.01437365,
-0.011909023,
0.0088900225,
0.018688416,
-0.026342787,
-0.030751063,
-0.000013736725,
-0.012283059,
-0.014961421,
0.026543163,
0.011715326,
0.021466967,
0.00068962795,
-0.010506391,
-0.004027561,
0.013879389,
-0.015054929,
-0.03085793,
-0.016430845,
0.033075426,
-0.0002945112,
-0.0051797237,
0.010887105,
0.026930556,
-0.014159916,
0.03395708,
0.011648535,
0.030911364,
-0.022989824,
-0.005410156,
-0.013812597,
-0.0075808982,
-0.01932962,
0.011147594,
-0.0070398827,
0.030243443,
0.04178511,
0.0035767145,
0.002673352,
-0.013037809,
0.0038271847,
-0.018100647,
0.0025748338,
-0.012870829,
0.027892362,
0.013144677,
0.0050628376,
0.0031325475,
-0.03539979,
-0.02673018,
-0.0012055966,
0.026676746,
0.016778164,
0.007560861,
0.012590302,
-0.009684848,
-0.0034865453,
0.011134235,
0.024552759,
-0.021012781,
-0.019035736,
0.0034180833,
0.013124639,
0.034117382,
0.008108555,
-0.034010515,
-0.042105712,
-0.009517868,
0.025461132,
-0.001790027,
0.0037470344,
0.018968944,
0.021640625,
-0.021493683,
0.040315684,
0.011541667,
0.017967062,
0.01950328,
0.00478899,
-0.0037002799,
0.012563585,
0.0053166477,
0.0400218,
0.004448351,
-0.008950136,
0.05514352,
-0.0006541447,
0.018207515,
-0.018447965,
-0.006582357,
-0.012450039,
0.004024221,
0.017606385,
0.026796972,
0.039754633,
0.027251158,
0.019703656,
-0.0059545115,
-0.01168861,
-0.011882307,
0.024579477,
0.011514951,
0.017365934,
-0.03243422,
0.005673985,
0.0063252077,
-0.008475912,
-0.008482591,
0.014480517,
-0.009183908,
-0.012590302,
0.00092006056,
-0.008736401,
0.009097078,
0.0088031925,
-0.009357567,
0.006682545,
-0.05818924,
0.020945989,
0.013692372,
-0.00462201,
-0.025888601,
-0.012904225,
-0.012950979,
-0.011281178,
0.012122758,
-0.0066023944,
0.006699243,
0.025581356,
0.010132355,
-0.0054435525,
-0.03168615,
0.044857543,
0.009304133,
0.0017048672,
-0.009704886,
0.0017115464,
-0.00065456214,
-0.015442323,
-0.024753135,
0.041598093,
0.019823883,
0.0054903068,
-0.013037809,
0.0004692142,
-0.023884838,
0.015268664,
-0.013358411,
0.011875628,
-0.022495564,
-0.0134318825,
0.04170496,
-0.030243443,
0.015041571,
0.0067894123,
-0.017659819,
-0.017098766,
-0.009945337,
0.010820312,
-0.018341098,
0.02580845,
-0.019663582,
0.0074873893,
0.008856626,
-0.014159916,
0.01109416,
-0.0063085095,
-0.015375531,
0.03043046,
-0.007681086,
0.009871866,
0.01546904,
0.0074005597,
-0.008355686,
0.022762733,
0.034117382,
-0.021921152,
-0.021453608,
0.0057875314,
-0.0058209277,
0.021747492,
0.0037503738,
0.013545428,
0.022174962,
0.02815953,
-0.017926987,
0.034598283,
0.018114006,
0.019409772,
-0.016497638,
-0.024258874,
-0.005794211,
-0.010880426,
0.016136961,
-0.033476178,
-0.03868596,
-0.014427084,
-0.0061081336,
0.0046053124,
0.016430845,
0.011114198,
0.01513508,
-0.0067159412,
-0.001580467,
-0.022802807,
-0.020718895,
0.018688416,
0.008028405,
-0.0026149089,
-0.03385021,
0.008335648,
0.014226708,
-0.0089902105,
0.0078948205,
0.010606579,
0.0030824533,
-0.0020705536,
-0.01513508,
-0.01915596,
-0.015428965,
-0.0035600166,
-0.026382862,
0.009524547,
-0.025848525,
0.0074606724,
-0.0131580345,
0.00089751824,
-0.023884838,
-0.0024312309,
0.00504614,
0.018194156,
-0.010960576,
-0.025888601,
0.022468848,
-0.009931979,
-0.004986027,
0.010459635,
-0.008075159,
0.0025998808,
0.05346036,
-0.013064526,
-0.009952016,
0.015028212,
-0.03473187,
-0.014787761,
-0.013091243,
-0.015883151,
0.009123795,
-0.0007668563,
0.015362172,
0.022535639,
-0.030243443,
0.010472994,
-0.02445925,
-0.014841194,
0.004782311,
0.021026138,
-0.0038772789,
-0.016991898,
-0.0014393688,
-0.015963301,
-0.011808835,
-0.0017816781,
-0.041224055,
-0.0018651681,
0.017539594,
0.0011154274,
-0.007420597,
0.006084756,
0.0012473416,
-0.009070361,
0.0077946326,
-0.015268664,
-0.0018685077,
0.028212965,
0.029281637,
-0.0017699895,
0.033102144,
0.004141107,
-0.011929061,
-0.004565237,
0.036869213,
0.023069976,
-0.010058884,
-0.02471306,
0.00689294,
0.0137057295,
-0.028693866,
-0.016871672,
-0.018287664,
-0.0010603239,
0.03422425,
-0.0058276067,
-0.0030741044,
-0.044243056,
0.008121914,
-0.021907793,
-0.01421335,
-0.012824074,
-0.010559824,
0.0033729987,
-0.0018468003,
0.009290775,
0.013972898,
0.014747686,
-0.021907793,
-0.0075808982,
0.0030891325,
-0.04464381,
0.017833479,
0.009911941,
0.007701124,
-0.014827836,
-0.010265939,
-0.032407504,
-0.034625,
-0.038979843,
-0.006044681,
0.001083701,
0.050735246,
0.011368007,
-0.011107518,
-0.017005257,
0.021881077,
0.0034498097,
0.007868104,
-0.02622256,
0.007186825,
-0.034250967,
0.033048708,
-0.008028405,
-0.010032167,
0.024485968,
-0.026850406,
0.016524354,
0.005590495,
-0.011508271,
-0.0072001833,
0.0067894123,
-0.026957273,
-0.030323593,
0.006361943,
-0.011174311,
-0.023216918,
-0.0185014,
-0.010880426,
0.0050561586,
-0.021747492,
0.02355088,
0.003002303,
0.0054435525,
-0.00487582,
0.021026138,
0.008048442,
0.01009228,
-0.017833479,
-0.016136961,
-0.0003688174,
-0.00088249,
0.02606226,
0.026676746,
0.009611377,
-0.024098573,
-0.016631221,
-0.032728106,
0.014747686,
0.0016672966,
-0.003723657,
0.009083719,
-0.025100455,
0.0062350384,
0.015669417,
-0.025795091,
-0.019369695,
0.0031175192,
0.003900656,
-0.030216726,
0.00016520597,
-0.038552374,
-0.019556714,
0.018447965,
-0.027758777,
0.01336509,
-0.0073270886,
0.029815974,
0.022829525,
0.014574027,
0.0018033854,
-0.012122758,
-0.0106199365,
-0.0066224323,
0.015068288,
0.011995853,
-0.0032360752,
-0.011354649,
-0.026129052,
0.013318336,
-0.017940346,
-0.039140143,
0.009451075,
0.003354631,
0.016604505,
-0.006655828,
-0.014747686,
-0.014560668,
0.023096692,
0.0036936007,
0.006415377,
0.00033896966,
-0.032060187,
-0.010686729,
0.0035934125,
0.003967448,
0.025848525,
0.0010361117,
-0.013144677,
0.0035867332,
-0.014440442,
0.016871672,
-0.0029605578,
-0.019436488,
0.020451726,
0.009050324,
-0.015883151,
-0.0090770405,
0.0034865453,
0.021707417,
-0.013745805,
-0.0015904858,
0.04036912,
0.012964338,
-0.002085582,
0.033422746,
-0.012910904,
-0.012503473,
-0.015335456,
-0.018007139,
-0.02328371,
-0.022348622,
-0.0043147667,
0.010032167,
0.0144538,
-0.016844956,
0.007574219,
-0.018087288,
-0.01411984,
-0.010880426,
-0.0017683196,
0.019276187,
-0.04229273,
-0.021907793,
-0.018220872,
-0.019984182,
-0.000010775437,
-0.0063285474,
-0.0017783385,
0.0031659433,
-0.000006437867,
-0.011087481,
0.00012012134,
0.014480517,
0.008676288,
-0.019529996,
-0.0028269738,
-0.013839314,
-0.029441938,
0.008041764,
0.0026967293,
-0.0119891735,
-0.014801119,
-0.013017772,
-0.0049492912,
0.026436295,
-0.013298298,
0.007634332,
0.014801119,
0.031418983,
0.0029054545,
-0.025087096,
0.010666691,
-0.012156154,
0.0010478004,
0.026275994,
-0.015762925,
-0.0042980686,
-0.001311629,
0.014012973,
0.019690298,
0.001471095,
-0.010867068,
-0.028212965,
0.020705538,
-0.01253019,
-0.0039140144,
-0.0075207856,
-0.0098985825,
-0.010446277,
0.00057733385,
0.01604345,
-0.022762733,
-0.013972898,
0.007828029,
-0.010466315,
-0.007380522,
-0.013638938,
0.005019423,
-0.017726611,
-0.021894436,
-0.02160055,
-0.011054085,
-0.016844956,
0.018367816,
0.014520593,
-0.025688224,
-0.017512877,
0.0072669755,
-0.035960842,
0.0009684848,
-0.0061315107,
0.024405817,
0.013972898,
0.009992091,
-0.004642048,
0.009364246,
-0.0038038075,
0.0012490114,
0.008128593,
0.007507427,
0.014654177,
-0.00014308111,
0.020398293,
0.003807147,
-0.048624616,
-0.016150318,
0.030617477,
-0.016364053,
-0.012116078,
0.023497446,
-0.0069330153,
0.031899884,
-0.0070465617,
0.012136117,
0.020037616,
-0.0030974816,
0.014894628,
-0.030644195,
-0.007086637,
0.008175348,
0.002068884,
-0.018114006,
-0.0030724346,
-0.0036334877,
-0.01867506,
0.013719088,
-0.019383054,
-0.020331502,
-0.002429561,
0.0065255836,
-0.007340447,
0.0036802422,
0.0014685903,
0.0020722235,
0.008469232,
-0.011267819,
-0.015148438,
0.008389082,
0.0018902152,
0.007013166,
0.021734135,
0.0012949309,
0.0070732785,
0.0059444928,
-0.0010695078,
-0.011301216,
0.0005748291,
0.0061615673,
-0.0030841231,
-0.009818432,
0.013612221,
0.013037809,
0.013605542,
0.003127538,
0.0004967659,
-0.0142400665,
-0.025234038,
-0.003060746,
0.001723235,
-0.013131318,
-0.0015646039,
0.018127363,
-0.0014644158,
0.007440635,
0.013892747,
-0.009851828,
-0.018367816,
0.022041379,
0.18744522,
0.011120877,
0.0200109,
0.022575714,
0.015068288,
0.0069062985,
0.017659819,
-0.0033479517,
-0.010506391,
0.0075207856,
0.028693866,
-0.009644773,
-0.008135272,
-0.014266783,
0.0035767145,
-0.011107518,
-0.033102144,
-0.0341441,
-0.006816129,
0.0015261985,
-0.013525391,
0.019262828,
0.024312308,
-0.011541667,
0.017593028,
0.0074005597,
0.008161989,
0.005049479,
0.01890215,
0.018942228,
-0.004167824,
0.023858123,
0.011534988,
0.009618056,
0.006993128,
-0.019676939,
-0.023150126,
-0.007320409,
-0.0049726684,
-0.005744117,
-0.00823546,
-0.004835745,
-0.035800543,
-0.0008227946,
0.0044850865,
0.015856434,
0.0017115464,
-0.03328916,
0.003429772,
0.0025598055,
-0.01713884,
0.0034898848,
0.025915317,
0.02194787,
-0.001126281,
-0.017726611,
0.013291619,
0.008869985,
-0.0064688106,
-0.005346704,
-0.0001604053,
-0.006084756,
-0.0060647186,
0.005840965,
-0.002067214,
0.03246094,
-0.035960842,
-0.006886261,
-0.008208743,
-0.0012339832,
0.009891903,
0.006966411,
0.016698014,
0.0050127436,
0.010553145,
-0.023657747,
0.02715765,
0.03924701,
0.028800733,
-0.005019423,
-0.0068328273,
0.010292656,
-0.0058810404,
0.0040809945,
-0.015068288,
-0.04672772,
0.007373843,
0.017112125,
-0.015936585,
0.008462553,
-0.0042412956,
-0.022722658,
-0.024766494,
0.015482399,
0.022428771,
-0.020772329,
-0.0062617552,
0.0070665996,
0.0030891325,
-0.0031258683,
-0.010566503,
0.08912732,
-0.011875628,
0.017419368,
-0.028854167,
0.027598478,
-0.019369695,
0.003994165,
0.0052665537,
0.013825956,
-0.016631221,
-0.011648535,
0.0011646864,
-0.022709299,
-0.018862076,
0.0243791,
0.031579282,
-0.017045332,
0.014841194,
-0.011501592,
0.008642892,
0.0010728474,
-0.008736401,
0.008970173,
0.000024146893,
0.0065689986,
-0.014413726,
-0.0077812746,
-0.0042680125,
-0.012810716,
-0.03152585,
0.002967237,
0.005319987,
0.0074005597,
-0.008355686,
0.030403743,
0.0055337218,
0.0015562549,
-0.017806761,
-0.0048491033,
-0.00071425753,
-0.0018902152,
0.002892096,
0.02555464,
0.016243828,
-0.017352575,
0.002705078,
-0.0006954723,
-0.028025946,
-0.000542268,
-0.010072242,
-0.021226514,
-0.0042245975,
-0.006993128,
0.009544585,
-0.0028987753,
0.0042513143,
-0.029655673,
0.018447965,
0.02530083,
-0.026917199,
0.0094377175,
0.03219377,
-0.014346933,
-0.01488127,
-0.007560861,
-0.1682091,
0.007300372,
0.00084199733,
-0.0032143677,
0.04547203,
0.0062417174,
0.003312886,
-0.001352539,
-0.0017883573,
0.0040041837,
0.004758934,
-0.015282022,
-0.011962457,
-0.017165558,
0.0062116613,
0.0066691865,
0.002033818,
0.028186247,
0.014266783,
0.0043080878,
0.019570071,
0.00024817424,
-0.0022041379,
-0.041330922,
0.00891006,
-0.008015047,
-0.005243176,
-0.0039106747,
0.0060313228,
0.00066291116,
-0.0076944446,
0.0059812283,
0.040315684,
0.002083912,
-0.0033429423,
-0.015402248,
0.0107935965,
-0.0036936007,
0.0054936465,
0.021800926,
0.029815974,
0.00865625,
0.0056138723,
-0.016457561,
-0.018100647,
0.01513508,
-0.00068461854,
-0.021199798,
0.0076543693,
-0.000015497844,
0.021747492,
0.0027601817,
0.003934052,
0.006615753,
0.044857543,
0.009023607,
0.0074807103,
0.0046787835,
0.013972898,
-0.009170549,
-0.019022377,
0.011414763,
0.015963301,
0.011628496,
0.005767494,
-0.020037616,
0.011341291,
0.002538098,
-0.013204789,
0.037697434,
-0.02043837,
-0.0036301482,
0.033770062,
-0.022415414,
0.026449654,
0.027184367,
-0.028586999,
0.008248819,
-0.010205826,
0.021613909,
-0.012142795,
0.0155224735,
0.00023272856,
-0.012543548,
-0.0010194137,
0.014680894,
0.01554919,
0.0015003165,
0.006298491,
-0.0027334648,
0.0030540668,
-0.021213157,
0.024445891,
-0.023444012,
-0.002294307,
0.016377412,
0.0042713517,
0.0030340292,
0.0026750218,
0.0043014083,
0.023337144,
-0.008536025,
-0.0033212348,
-0.009451075,
0.03539979,
0.007961613,
0.015175154,
0.015495757,
0.014560668,
0.013218148,
0.010539786,
0.005553759,
0.0054001375,
0.01807393,
-0.028880885,
0.016163677,
0.00064412586,
-0.011354649,
-0.01168193,
-0.040155385,
0.052071087,
0.017793404,
0.025741657,
0.017432727,
-0.0029238223,
-0.03387693,
-0.13978241,
-0.0068528648,
0.03924701,
0.002673352,
0.002740144,
0.013598862,
0.0023277032,
0.012770641,
0.007160108,
0.013719088,
-0.0054034772,
-0.02043837,
-0.0032227167,
-0.0042913896,
0.010553145,
0.0106199365,
-0.013311656,
-0.004842424,
-0.034999035,
0.033903647,
-0.013057847,
-0.010633295,
0.017593028,
0.0016455892,
-0.01193574,
0.021440249,
-0.010058884,
0.03280826,
0.0029488693,
0.014600744,
0.012122758,
-0.0026983991,
0.0023610992,
0.021199798,
-0.026195845,
-0.016190395,
-0.008462553,
-0.02606226,
0.05078868,
-0.03278154,
0.017753327,
-0.004555218,
0.025527922,
-0.009404321,
-0.0026249278,
-0.026422936,
-0.03673563,
-0.001202257,
0.018127363,
0.009223983,
-0.017205633,
-0.04565905,
-0.03999508,
-0.009604697,
0.031632718,
-0.013825956,
-0.0019887334,
0.00045168126,
-0.018060572,
-0.016951824,
-0.013692372,
-0.009050324,
-0.025741657,
-0.0026449654,
0.024739778,
-0.002623258,
0.005590495,
-0.031552568,
0.012503473,
-0.008556062,
-0.013879389,
-0.004094353,
-0.0052498556,
0.025193963,
-0.012369889,
0.011140915,
-0.009731603,
-0.00037967108,
0.016604505,
-0.018541474,
-0.013892747,
-0.021894436,
0.014867911,
-0.010726804,
0.016430845,
0.013759163,
0.00252307,
0.0021907794,
0.004698821,
-0.027518326,
-0.012590302,
0.0243791,
-0.011715326,
0.0030290196,
0.0019787147,
0.024699701,
-0.019129245,
-0.022989824,
0.008602817,
0.03515934,
-0.023029901,
-0.018367816,
-0.057548035,
0.00933085,
0.027291233,
0.0034598284,
0.006532263,
0.0074005597,
0.042025562,
0.009865186,
0.0016322308,
-0.0032310656,
-0.038205054,
0.00588772,
-0.012430001,
0.014894628,
-0.012890867,
-0.00529661,
0.036949366,
-0.00041244095,
0.008375724,
-0.008696325,
0.002060535,
0.00036526905,
0.00891006,
0.02598211,
0.011655213,
0.003429772,
-0.009143832,
0.03419753,
-0.017299142,
0.0028904262,
-0.0009384284,
-0.0378043,
-0.005607193,
-0.01311128,
-0.01042624,
-0.0055270423,
-0.0047956696,
0.015642699,
0.004050938,
0.028560283,
-0.022161603,
-0.032140337,
0.009157191,
-0.023230277,
-0.0040809945,
0.009704886,
-0.028560283,
0.02941522,
0.0017733291,
-0.012289738,
0.02177421,
-0.0041043716,
-0.0026983991,
-0.052258104,
-0.022762733,
-0.01068005,
0.010185788,
-0.013351732,
-0.025995467,
-0.034892168,
0.029441938,
0.011074123,
-0.026636671,
-0.015682774,
0.00866293,
-0.019409772,
-0.0028870865,
-0.015856434,
0.0035666958,
0.0014001285,
-0.03457157,
-0.01891551,
-0.0068996195,
0.01807393,
0.022816166,
-0.0028804073,
-0.020050975,
-0.0074072387,
-0.0036535254,
0.008829909,
0.00823546,
-0.008809872,
-0.021707417,
0.0011805496,
0.0066124136,
-0.020237993,
0.005640589,
0.018862076,
-0.02294975,
0.014186633,
0.015816359,
0.011221065,
-0.008108555,
0.015495757,
-0.003650186,
0.02799923,
-0.01740601,
-0.010439598,
-0.0010077251,
0.018955585,
0.008729721,
0.006919657,
-0.0062617552,
-0.002705078,
-0.01311128,
0.021814285,
-0.023069976,
-0.023310427,
-0.026997348,
0.012136117,
0.033155575,
0.019129245,
0.004986027,
-0.004328125,
-0.0033345933,
0.008696325,
-0.013605542,
-0.01640413,
-0.004735557,
0.0155224735,
-0.02091927,
0.01403969,
-0.007534144,
-0.00013149685,
0.0033913667,
-0.019102527,
0.00933085,
-0.027197724,
0.027758777,
-0.019516638,
-0.0029054545,
-0.0038605807,
-0.028025946,
-0.0002588192,
0.012637056,
-0.02220168,
-0.011454837,
0.019730372,
-0.010579862,
0.067646995,
-0.0045785955,
-0.029789256,
-0.014226708,
-0.012630378,
0.004525162,
0.00053016195,
0.01950328,
-0.03294184,
-0.020612027,
-0.0016096885,
-0.0032460939,
0.009724923,
-0.0173125,
-0.027865645,
0.024312308,
-0.014106482,
-0.00050636724,
-0.0010060553,
-0.010306014,
0.017940346,
-0.012596982,
-0.01177544,
-0.0014953071,
-0.018848717,
-0.023991706,
0.012857471,
-0.020278068,
-0.009965374,
-0.057548035,
-0.0013149686,
-0.0011872288,
-0.017873554,
-0.0146141015,
0.008495949,
0.0026182486,
-0.017793404,
-0.012456718,
0.007514106,
0.026409578,
-0.008956814,
0.04245303,
-0.034250967,
-0.038285207,
0.0003940731,
-0.024192082,
0.004525162,
-0.012142795,
-0.0030540668
] |
Mutations in BLM cause Bloom's syndrome, a disorder associated with cancer predisposition and chromosomal instability. We investigated whether BLM plays a role in ensuring the faithful chromosome segregation in human cells. We show that BLM-defective cells display a higher frequency of anaphase bridges and lagging chromatin than do isogenic corrected derivatives that eptopically express the BLM protein. In normal cells undergoing mitosis, BLM protein localizes to anaphase bridges, where it colocalizes with its cellular partners, topoisomerase IIIalpha and hRMI1 (BLAP75). Using BLM staining as | [
-0.026013175,
-0.009375099,
-0.017128633,
-0.033303406,
-0.030605339,
0.032186024,
-0.027048796,
0.027362209,
-0.008966302,
0.018191507,
-0.008802782,
-0.005733391,
0.017728204,
0.04273301,
-0.021557277,
0.013694731,
0.014444194,
-0.013790117,
-0.0030881276,
0.009347846,
-0.033412416,
0.011166996,
-0.012822628,
-0.031232161,
-0.000079417514,
-0.011998219,
0.027021542,
-0.035701685,
-0.019526914,
0.01509827,
0.013027027,
0.014812112,
-0.006646373,
-0.0062546083,
-0.019472407,
-0.0038461073,
0.020930454,
-0.0066054934,
0.020944081,
-0.035701685,
0.019717686,
0.0059650433,
-0.01325868,
-0.0068814317,
-0.009136634,
0.008353104,
0.0051951404,
0.0012178771,
-0.010710506,
-0.013381319,
0.021802556,
0.014934751,
-0.027062424,
-0.0072084703,
-0.0040062196,
-0.01658357,
0.008802782,
-0.0037575343,
-0.023614893,
0.0085983835,
0.006782639,
-0.00453425,
-0.021966076,
0.000014451645,
0.002791749,
-0.017155886,
0.008864102,
0.011746127,
0.020399017,
-0.017564684,
0.047039013,
0.01697874,
-0.00987247,
-0.026258454,
0.0019486034,
-0.020739682,
-0.036955334,
-0.022293113,
-0.012263938,
0.018450413,
0.02767562,
0.012086792,
-0.0014026879,
0.019486034,
0.01573872,
0.00073413295,
-0.004878322,
-0.0084076105,
0.006373841,
-0.00066301913,
0.0008069501,
0.01509827,
0.020562535,
-0.0013899129,
-0.01375605,
0.011902833,
-0.010029176,
0.035510913,
-0.0072493497,
-0.02967873,
0.00915026,
-0.0026657032,
-0.025440857,
-0.0011207877,
-0.0262312,
-0.027852766,
0.018682064,
-0.0066634063,
0.00995423,
-0.012052726,
-0.0209032,
-0.00083335163,
-0.0063806544,
-0.057940293,
0.015302669,
-0.017850842,
0.00047863423,
0.0011471892,
0.006816705,
0.006022956,
0.009668071,
0.022524767,
-0.0038222605,
-0.01994934,
0.029133666,
0.010581053,
-0.03104139,
-0.005675478,
-0.019158997,
-0.0046398565,
0.0077944137,
0.032049756,
-0.0009342736,
-0.0030387312,
-0.005382506,
-0.0077399076,
0.00073711376,
-0.022047834,
-0.022919938,
-0.022715539,
-0.010969411,
0.02511382,
-0.016351918,
0.0056925113,
0.0058049303,
0.02054891,
-0.014239795,
-0.0024153143,
-0.0141444085,
-0.0020950893,
-0.0030353246,
-0.004033473,
0.0065135136,
-0.018314147,
0.012693176,
0.026299333,
-0.0057572373,
0.02534547,
-0.026558239,
-0.0418064,
-0.0021478925,
0.0027321328,
0.011126117,
0.014294301,
0.022892684,
0.043278076,
-0.023805667,
-0.01377649,
-0.019186249,
-0.016883355,
0.013980889,
0.02170717,
-0.036955334,
0.02511382,
-0.01898185,
0.0064794472,
-0.013238239,
0.0123661375,
-0.0016053836,
-0.0105538,
-0.02302895,
0.030687097,
0.034938596,
-0.0072152833,
-0.03684632,
0.009661257,
0.04682099,
-0.017169513,
-0.0043639177,
-0.0157796,
-0.0013566981,
-0.0012068056,
0.014321554,
-0.019731313,
-0.6157042,
-0.031232161,
0.004898762,
0.0014725243,
-0.0050452477,
0.018123375,
0.003703028,
-0.002260312,
-0.02267466,
0.013374506,
-0.0151391495,
0.02486854,
-0.0009777084,
-0.017469298,
0.0028649922,
-0.048646953,
-0.00089424546,
-0.017414792,
0.019022731,
-0.0029416417,
-0.014008142,
-0.018995477,
-0.028261563,
0.019131742,
-0.034747824,
0.016161146,
0.042896528,
-0.007412869,
-0.0030438413,
0.02935169,
-0.025290966,
0.016733462,
-0.0130065875,
0.00096663676,
0.04434095,
-0.005549432,
0.00056039385,
0.0155070685,
0.038944814,
0.02379204,
-0.003662148,
-0.002994445,
0.023465002,
0.0043366645,
-0.015616081,
0.010935345,
0.014566833,
0.00082824164,
0.030714352,
0.00067025825,
0.017673697,
0.011282823,
-0.018123375,
-0.0035906085,
-0.0043366645,
0.025290966,
0.026490105,
-0.008748275,
0.0168561,
0.0077194674,
-0.017046874,
0.0071471506,
-0.024882168,
-0.0022126187,
-0.004837442,
0.01375605,
-0.021271119,
0.009184327,
0.0018038208,
-0.0042208387,
0.015874986,
0.027621113,
-0.007365176,
0.0042821583,
0.0035292888,
0.027362209,
-0.009777084,
0.04041649,
-0.0052803066,
-0.00091724034,
0.001314115,
-0.009565871,
-0.014825738,
-0.019595047,
0.023015324,
0.018791078,
-0.019390648,
0.0107786385,
-0.024568755,
-0.000731578,
0.029188173,
0.003525882,
-0.0075559486,
-0.043632366,
-0.01990846,
0.017401164,
-0.0077603473,
0.01181426,
0.0036723681,
-0.041070566,
-0.009450045,
-0.021352878,
0.0023982811,
0.01189602,
0.0065578,
0.022429379,
-0.027743753,
0.007773974,
0.020944081,
-0.010390281,
-0.003200547,
0.0009317186,
0.009238834,
-0.019513289,
0.0051951404,
-0.018000735,
0.008066946,
0.0019486034,
-0.006901872,
-0.019990219,
0.009204767,
-0.0020525062,
0.010839959,
-0.018682064,
0.015289042,
0.011909646,
0.014648592,
-0.014566833,
-0.0057061375,
-0.0020201432,
0.0072834166,
-0.0043605114,
0.03684632,
-0.020276377,
0.03559267,
-0.0126863625,
0.004217432,
0.0044558975,
-0.0032329103,
-0.024364356,
-0.013980889,
0.0053586597,
0.021966076,
0.008918609,
-0.021720797,
-0.008925421,
-0.01786447,
0.0025158105,
0.0036042351,
0.0060944958,
0.010247202,
0.008516624,
-0.027103303,
0.0092728995,
0.019049983,
-0.009565871,
-0.016678955,
-0.016651703,
-0.011950526,
-0.02759386,
0.0074741887,
-0.0061149355,
0.015915865,
-0.0011608158,
0.017946228,
-0.010969411,
0.012338884,
0.0020422863,
-0.017714577,
-0.025154699,
-0.00033981327,
-0.019690434,
-0.022879057,
-0.0000035031267,
-0.0045240303,
0.021611784,
-0.0067076925,
-0.0038154472,
-0.014880245,
0.008216838,
0.009470485,
-0.006414721,
-0.0110034775,
-0.021952448,
0.026817145,
0.022647405,
0.044804253,
-0.0071948436,
0.020453524,
0.02503206,
-0.00051610736,
0.033412416,
-0.0027202095,
-0.0037098413,
0.0106832525,
0.006172849,
0.0004139079,
-0.0007200805,
-0.012202618,
0.029542463,
-0.0013302966,
-0.012311631,
0.0010765012,
0.012870321,
0.01445782,
-0.024200838,
-0.00859157,
-0.018518547,
-0.0095454315,
0.0045410637,
0.0011965856,
0.015588827,
-0.00081717,
-0.005685698,
0.006493074,
-0.012795375,
-0.01133733,
0.006026363,
0.013285933,
-0.011064798,
-0.008175959,
0.010254014,
0.011201063,
-0.008652889,
-0.0010705396,
-0.0085983835,
0.030578084,
0.034121,
0.012073166,
0.022429379,
-0.0012664219,
0.037500396,
0.0049021686,
0.014784859,
-0.0107786385,
-0.000731578,
0.017401164,
0.00026976404,
0.030741604,
-0.016638076,
-0.004704583,
0.03733688,
-0.004622823,
-0.0019843732,
0.030441819,
0.008898168,
0.02294719,
0.033276152,
0.014634966,
0.023355989,
-0.025699763,
0.00784892,
-0.006315928,
0.0020133299,
-0.010703692,
-0.016515436,
0.0014197212,
0.02022187,
0.05306197,
-0.0037677542,
0.023206096,
-0.017033247,
0.003362363,
0.010063242,
-0.008537063,
-0.017973483,
-0.0022841585,
0.014757605,
-0.008169145,
0.014607713,
-0.02166629,
-0.0003142634,
0.022579271,
-0.058321837,
0.0060604294,
0.027198689,
-0.0071267104,
0.024023691,
0.027307702,
0.014089902,
-0.021897942,
-0.041479364,
0.019022731,
0.03281285,
-0.022102341,
-0.0121889915,
-0.015915865,
0.0048646955,
0.0012519436,
0.00923202,
0.008312224,
0.015261789,
-0.0072084703,
0.010199509,
0.0022773452,
-0.026844397,
0.009238834,
-0.016011253,
0.0315592,
0.003730281,
-0.0019690434,
0.02278367,
-0.006677033,
0.01371517,
0.031313922,
0.017905349,
0.021843435,
0.0030319178,
-0.0077399076,
-0.039598893,
-0.005004368,
-0.040907048,
-0.005975263,
0.0056380047,
-0.0060502095,
-0.005985483,
0.027334955,
-0.005413166,
-0.0008482557,
-0.0070108846,
-0.029787742,
-0.024187211,
-0.01958142,
-0.00038048017,
0.026653625,
0.029242678,
-0.00786936,
0.016283784,
0.002517514,
0.019731313,
0.007835293,
-0.030905124,
0.013483519,
-0.028125297,
-0.017728204,
-0.012945267,
0.018055242,
-0.0022466853,
-0.005004368,
0.0375549,
0.008911795,
-0.023233349,
0.023219721,
0.0148666175,
0.006905278,
-0.012073166,
0.017510178,
0.05603257,
0.0048340354,
-0.0024085012,
-0.0032192837,
0.012986148,
-0.009034434,
-0.019608675,
-0.028888388,
-0.0012672736,
0.004401391,
0.011453155,
0.026571866,
-0.026340213,
0.0013413682,
-0.0024749308,
0.0010628746,
0.012672735,
0.020071978,
0.007590015,
-0.0064692274,
-0.0042787516,
-0.0085983835,
-0.0073924293,
0.011371396,
-0.0025924603,
-0.014321554,
0.0063670278,
0.01862756,
-0.028779374,
-0.022851804,
-0.027362209,
0.018845584,
-0.0028036723,
0.0022841585,
0.0017646444,
-0.0080533195,
-0.018886464,
-0.0059616365,
-0.016433677,
0.003798414,
0.0021223426,
0.00022867134,
-0.00981115,
-0.018068869,
0.017469298,
-0.027961778,
-0.013647038,
0.0014001329,
-0.026721759,
-0.039598893,
-0.026776263,
0.019254383,
0.021816183,
0.0017936009,
-0.005668665,
-0.005617565,
0.03523838,
-0.004060726,
-0.014948377,
-0.0015806854,
-0.024814034,
-0.02278367,
0.0031562606,
0.022102341,
-0.03180448,
-0.04812914,
0.010076869,
-0.009238834,
-0.020766934,
0.0005655038,
-0.0043639177,
0.0053007463,
0.014280674,
0.012216245,
0.02959697,
0.006952971,
0.008782342,
0.004023253,
-0.021775303,
-0.046548456,
-0.0076581477,
-0.004837442,
-0.00061106775,
-0.01778271,
0.011677994,
0.0031238976,
0.014049022,
-0.019213503,
-0.018246014,
-0.00067409076,
-0.006871212,
0.037173357,
0.04153387,
0.00649648,
0.019022731,
0.013142853,
-0.0026197133,
0.0027099897,
-0.040034942,
0.0211076,
-0.004343478,
0.008073759,
0.012897574,
0.0028053757,
-0.016965114,
-0.010172255,
0.004200399,
-0.0023642147,
0.02430985,
0.005801524,
-0.015602455,
-0.025945041,
-0.0043707313,
0.0049703014,
0.0075832014,
-0.0013004884,
-0.0005156816,
-0.013435825,
0.018573053,
0.0070176977,
-0.016869728,
0.011146557,
-0.034257267,
-0.011970966,
0.00465689,
-0.0041901786,
-0.011105677,
-0.0006843107,
0.011425902,
-0.03537465,
-0.013640224,
0.00793068,
-0.019172622,
-0.0023574014,
-0.028561348,
0.027961778,
0.01802799,
0.035429154,
0.0020371764,
0.038999323,
0.019472407,
0.019431528,
-0.0051372275,
-0.02406457,
0.00797156,
-0.01766007,
0.028561348,
0.003336813,
0.030060275,
0.03976241,
-0.011180623,
0.014485073,
0.03829074,
-0.008864102,
-0.011078424,
0.0003904872,
-0.045676354,
-0.030578084,
0.0057776775,
-0.016610822,
-0.014049022,
-0.03665555,
-0.010874025,
0.008680142,
0.006053616,
-0.00853025,
0.00011561316,
0.029188173,
-0.009327406,
0.026803518,
-0.022524767,
-0.0098656565,
-0.010506107,
-0.018573053,
0.006908685,
-0.0095454315,
0.01674709,
-0.0196223,
0.007004071,
0.009504552,
-0.028261563,
-0.0085983835,
-0.00023782671,
-0.0056959176,
-0.012318444,
-0.0040913858,
-0.011310076,
0.0011335625,
-0.022156848,
-0.014089902,
-0.03889031,
0.016556317,
-0.0015747236,
-0.015915865,
0.026667252,
-0.0046432633,
-0.00004883751,
0.02783914,
0.0022722352,
0.012877135,
-0.035074864,
0.023056203,
0.008359917,
-0.023560388,
-0.035156623,
0.0065612067,
-0.0072425366,
0.012223058,
0.014035395,
0.024541503,
-0.018273268,
-0.0135993445,
0.014035395,
0.0061047156,
-0.003982373,
-0.033739455,
0.006459007,
-0.011303263,
0.019458782,
-0.0011190843,
-0.01978582,
-0.020085605,
0.007024511,
-0.028179804,
0.03343967,
0.0075559486,
-0.030469073,
0.0016385984,
-0.012631856,
-0.012774935,
0.018763825,
-0.005113381,
-0.012774935,
0.00848937,
-0.0112760095,
0.007842107,
0.0033657695,
0.0021019026,
0.042896528,
0.001200844,
0.0028019692,
0.012229871,
0.017837217,
-0.0012076572,
-0.02891564,
-0.010962598,
0.04017121,
-0.021775303,
0.009238834,
-0.028343324,
-0.0135993445,
0.0043366645,
0.01133733,
0.011780194,
-0.010874025,
-0.034121,
0.016665328,
0.021911569,
0.007882987,
-0.00033640664,
-0.013313185,
-0.01770095,
-0.0072629764,
-0.025127446,
-0.03303087,
0.023465002,
-0.055923555,
-0.01994934,
-0.0072357235,
0.018532172,
0.016256532,
0.008012439,
-0.009995109,
-0.0033708797,
0.030441819,
-0.008298598,
0.007991999,
-0.0078625465,
-0.00082696415,
-0.009395539,
0.010526546,
0.0036042351,
-0.010901278,
-0.008625636,
-0.006782639,
-0.021298371,
-0.016801596,
-0.026408346,
0.0077535342,
0.018695692,
-0.031014137,
0.0076922146,
-0.014580459,
0.029978516,
-0.009858843,
-0.014648592,
0.012359324,
-0.04049825,
0.023969185,
0.027443968,
0.0024936674,
-0.010165442,
0.000996445,
-0.015684213,
-0.017605564,
0.0039959997,
-0.00977027,
-0.025209205,
-0.018409533,
0.010758199,
-0.0030915344,
-0.00995423,
-0.00525646,
-0.019090863,
0.006636153,
0.0047079893,
0.0070653907,
0.008353104,
-0.0037779743,
0.015847733,
0.029378945,
-0.031014137,
-0.018818332,
-0.017646443,
-0.02779826,
-0.009967856,
-0.011507662,
0.011105677,
0.025522618,
0.005672071,
-0.0101858815,
-0.015929492,
-0.024037318,
-0.033548683,
-0.037118852,
0.012243498,
-0.0061558154,
0.0014997774,
0.04205168,
-0.0022994883,
0.015479815,
0.0028394423,
0.019036356,
0.008639263,
-0.0080056265,
0.018409533,
-0.021366505,
0.01299296,
0.018041614,
-0.014634966,
-0.011446342,
0.037745677,
-0.009368286,
-0.017237647,
0.03224053,
-0.013483519,
0.0064385673,
0.017673697,
0.013626598,
0.0067792325,
0.014594086,
0.0049021686,
-0.027171435,
-0.016869728,
-0.0028207058,
0.025181953,
-0.030714352,
0.03183173,
-0.015820479,
0.0057878974,
-0.009906537,
-0.015220909,
-0.014212541,
-0.0098179635,
-0.00071624806,
0.010029176,
0.015275416,
0.024936674,
0.02447337,
0.0024851507,
-0.010662813,
0.0037745675,
-0.01738754,
-0.016992368,
-0.012025473,
-0.002313115,
0.004013033,
-0.009831591,
0.006448787,
-0.005004368,
-0.021202985,
-0.012277564,
-0.0068473653,
-0.0072357235,
-0.04453172,
0.04232421,
-0.0031204908,
0.0051747006,
-0.017959855,
0.0036314882,
-0.04085254,
-0.021366505,
0.017510178,
0.0040368796,
-0.009715764,
0.016515436,
-0.01846404,
0.0012996368,
-0.011752941,
0.0019230536,
-0.00842805,
-0.0059820763,
0.003682588,
0.20832342,
-0.010465227,
-0.01850492,
0.03597422,
-0.0055630584,
-0.01890009,
0.019363396,
0.007085831,
-0.0025226239,
0.006809892,
0.008237278,
-0.031259414,
-0.017319405,
0.0010790562,
0.032594822,
0.016474556,
-0.012877135,
-0.012788562,
-0.014934751,
-0.014062649,
0.006441974,
-0.012127671,
0.013163294,
-0.0055937185,
0.014621339,
-0.002449381,
-0.012945267,
0.0050384346,
0.015425309,
0.0046977694,
-0.044177428,
0.000103530205,
-0.002471524,
-0.021298371,
0.0028394423,
0.012488777,
-0.014485073,
-0.0026401533,
-0.02058979,
0.0076513346,
-0.008945861,
-0.015656961,
-0.008271345,
0.0046296366,
-0.0007469079,
0.002900762,
-0.0042787516,
-0.010799078,
0.0091911405,
-0.010662813,
-0.04461348,
0.011282823,
-0.004101606,
0.03428452,
-0.02026275,
-0.004306005,
0.021938821,
0.005668665,
-0.000114442126,
0.0049021686,
-0.004476337,
-0.005859437,
-0.02054891,
0.009388725,
0.004217432,
0.016569942,
-0.010179068,
0.011739314,
0.03684632,
-0.033821214,
0.00921158,
-0.011064798,
-0.018995477,
-0.008652889,
-0.0110511705,
-0.01974494,
0.025686137,
0.022075089,
0.017346658,
0.017769083,
-0.0040266598,
0.000754147,
-0.025427232,
0.008121452,
0.007358363,
-0.014212541,
0.032267783,
0.01179382,
-0.00015787692,
-0.016351918,
0.0004897058,
-0.013456265,
-0.0060502095,
-0.0023880613,
-0.0016505216,
-0.0044354573,
0.01898185,
0.010628746,
-0.013326813,
-0.015398055,
-0.028861133,
0.055732783,
0.016801596,
-0.027171435,
-0.02058979,
0.0016488183,
0.0058832834,
0.01910449,
-0.01051292,
-0.014784859,
-0.00049949996,
-0.03921735,
0.0031886238,
-0.000653225,
-0.006404501,
0.008755089,
0.02054891,
-0.0315592,
0.027961778,
-0.029651476,
-0.0045887567,
-0.032186024,
0.021407384,
0.031450186,
-0.014798485,
0.008714209,
-0.010145002,
0.0028479588,
-0.020739682,
-0.022156848,
0.011241943,
-0.0075218817,
0.0039040202,
0.021693543,
-0.0043877643,
0.00043328322,
-0.012148112,
-0.031586453,
-0.018886464,
-0.020358136,
-0.012325257,
-0.0121889915,
-0.0018855805,
0.003927867,
-0.0037132478,
-0.0065032938,
0.023233349,
0.013347252,
-0.035074864,
-0.0023522915,
-0.0058253706,
-0.024105452,
-0.012740869,
-0.00029935932,
0.0004209341,
-0.028697614,
-0.016065758,
-0.042296957,
0.025604377,
0.041506615,
-0.002444271,
0.042678505,
0.016147519,
-0.0059207566,
0.0132314265,
-0.01437606,
-0.17256723,
0.012727242,
0.023396868,
-0.0071539637,
0.013701544,
0.020603415,
-0.004421831,
-0.0155070685,
0.0043775444,
0.02726682,
0.0124615235,
0.0024817442,
-0.024541503,
-0.026667252,
0.001039028,
0.008850475,
0.008046506,
0.021734424,
0.03234954,
-0.008986741,
0.0053007463,
-0.03303087,
0.041997172,
-0.0031818105,
-0.011582608,
0.018205134,
0.005491519,
0.0008214283,
-0.005614158,
-0.019758567,
-0.011861953,
-0.006765606,
0.020194618,
-0.023901053,
0.014321554,
0.004898762,
-0.006227355,
-0.0066395598,
0.009245646,
0.00044584525,
0.02150277,
0.040907048,
-0.00019833088,
-0.00008532592,
-0.01315648,
0.059139434,
0.020017471,
0.0035088488,
0.027989032,
-0.00043988362,
0.037418637,
-0.007358363,
0.024255343,
0.029024653,
-0.0038052273,
0.019199876,
-0.011664367,
0.023001697,
-0.017796336,
0.004122046,
-0.015398055,
-0.019853953,
0.027375834,
0.0029416417,
-0.018545799,
-0.02783914,
-0.0065339534,
0.007828481,
-0.032949112,
0.012481963,
-0.009586311,
0.0041390792,
0.017918976,
-0.018096121,
0.022797298,
0.02523646,
-0.009920163,
0.017346658,
-0.0026111968,
0.0027150996,
-0.013265492,
0.02959697,
-0.019417902,
-0.019676806,
-0.0056005316,
0.003064281,
0.00089935545,
0.008169145,
0.0019911865,
-0.0115962345,
0.01379693,
-0.019935712,
0.013783303,
-0.02170717,
0.021393757,
0.030496325,
-0.0053382195,
-0.010110935,
-0.0054540457,
-0.022960817,
-0.004275345,
0.006189882,
-0.028152552,
0.009027621,
0.045240305,
0.004946455,
0.014089902,
0.00331467,
0.027539354,
-0.024500623,
0.0011480409,
-0.020112857,
0.017755456,
0.018763825,
-0.005808337,
-0.0049566748,
0.0022688285,
0.007835293,
0.01958142,
-0.0043741376,
0.077399075,
-0.017932603,
0.008032879,
0.000365789,
-0.008400798,
-0.015793227,
-0.108794756,
-0.013210987,
-0.008891355,
0.015847733,
-0.0146894725,
-0.009668071,
-0.000035689976,
0.03224053,
-0.016869728,
0.04554009,
-0.022715539,
0.005808337,
-0.007773974,
-0.010894464,
0.0031290075,
0.012216245,
-0.0036008283,
-0.009511366,
-0.0032601634,
0.024636889,
0.015193656,
0.01197778,
-0.013027027,
-0.025890535,
0.039871424,
-0.0034662657,
-0.03848151,
0.008639263,
0.008400798,
0.017482925,
0.0006425792,
-0.009579498,
0.013940009,
0.01113293,
0.004977115,
-0.0029467517,
-0.007181217,
-0.032949112,
0.034393534,
-0.022443006,
-0.013040653,
0.013885503,
0.019853953,
-0.010417534,
0.0027474628,
-0.037418637,
-0.018613933,
0.02022187,
0.015302669,
-0.013272306,
-0.01049248,
-0.011344142,
-0.045867126,
-0.0058355904,
0.006632746,
-0.013367692,
-0.0022126187,
0.020780561,
-0.01866844,
-0.0044184243,
-0.012754495,
0.005062281,
0.0006800524,
0.012747682,
-0.0015023324,
-0.022647405,
-0.018654812,
-0.039980438,
0.04205168,
-0.027416714,
-0.011030731,
0.0109557845,
-0.02154365,
-0.01391957,
-0.035701685,
-0.0040573194,
-0.018368654,
-0.017673697,
-0.0012621636,
-0.014089902,
-0.009729391,
-0.018872838,
0.040116705,
-0.010546987,
0.030114781,
-0.0023846545,
0.011139744,
-0.0017680511,
0.011432716,
0.00055954215,
0.009681698,
0.023723906,
0.015125523,
-0.019990219,
-0.0087755285,
-0.002192179,
0.006901872,
-0.010996664,
0.030986883,
-0.005041841,
-0.010621933,
-0.0022228388,
-0.065135136,
0.025904162,
-0.018109748,
0.0035837952,
0.032376796,
-0.0055630584,
0.0016828848,
-0.014716726,
-0.0046296366,
0.034693316,
0.0014699692,
-0.0018685472,
-0.0016198618,
-0.01877745,
-0.006356808,
0.003021698,
0.036437523,
-0.011739314,
0.01898185,
0.027525727,
-0.004346885,
-0.011057984,
-0.0035292888,
0.018954597,
0.020044725,
-0.02534547,
0.011718874,
0.02743034,
-0.023287855,
0.0031988437,
0.025577124,
-0.030005768,
-0.022538392,
-0.0070790173,
-0.01049248,
-0.022211354,
-0.00053739897,
0.02875212,
0.028670361,
0.035510913,
-0.0038324806,
-0.022238607,
0.025086567,
0.0010398797,
-0.006673626,
0.0022160255,
-0.032785594,
0.00043519947,
0.023683026,
-0.006002516,
0.042351466,
0.016951486,
0.008625636,
-0.022129595,
-0.011037544,
0.006169442,
-0.004432051,
0.010833145,
-0.0017612377,
-0.009306966,
0.031068642,
0.015343549,
0.010642373,
0.0029620817,
-0.015561574,
0.0067894524,
-0.023369614,
0.012754495,
-0.017809963,
-0.027307702,
-0.024377983,
0.034502544,
0.0060093296,
0.00393468,
0.0025686137,
-0.006227355,
-0.017510178,
-0.011085237,
0.0046364497,
0.023574013,
0.013265492,
0.0041424856,
-0.008652889,
0.002817299,
0.02371028,
-0.015002884,
-0.024255343,
0.031777225,
0.0013507365,
-0.0021649257,
-0.019227128,
0.0132791195,
0.026203947,
0.012781749,
-0.0017356878,
0.031668212,
-0.009756644,
0.021938821,
-0.005770864,
0.022552019,
-0.012659109,
-0.022456633,
-0.017646443,
-0.009504552,
-0.031940743,
0.03512937,
-0.023056203,
-0.037473142,
0.005399539,
-0.0069700046,
0.020453524,
0.0032175803,
0.008087385,
0.011214689,
-0.0054267924,
-0.00058935035,
0.021489145,
0.016460929,
0.0121412985,
0.028370576,
0.019881206,
0.02383292,
-0.0011659258,
0.046357684,
0.022633778,
0.006459007,
0.012570537,
-0.0262312,
0.00328401,
-0.008748275,
0.030387312,
0.0081350785,
-0.057613254,
0.0003904872,
0.0035701685,
-0.007678588,
0.019513289,
0.012550096,
-0.022497512,
0.07243899,
0.0055528386,
-0.0029092785,
0.008904981,
-0.036137737,
0.019513289,
0.029978516,
0.0040675392,
-0.0135039585,
-0.030687097,
0.03829074,
-0.017578311,
0.018368654,
-0.027771005,
-0.03444804,
0.019499661,
-0.0036485216,
-0.009463672,
0.0016156035,
-0.027007917,
0.022170475,
-0.038835805,
0.017264899,
0.033112634,
-0.009899723,
0.0009981482,
0.014430567,
0.00465689,
-0.008373545,
-0.010989851,
0.019472407,
-0.03234954,
-0.037091598,
-0.010942158,
0.016556317,
-0.013319999,
0.010962598,
-0.00784892,
0.038236234,
-0.0024561943,
-0.028452335,
-0.0026571865,
0.0032124703,
-0.012965708,
0.022374874,
-0.014089902,
-0.0036928079,
0.0023539946,
-0.012379764
] |
BACKGROUND Corin has been suggested to be associated with hypertension by cell- and animal-based studies. However, the association still lacks population-based evidence which critically promotes translation from basic research to clinical and preventive practice. Here, we aimed to explore the association in a general population of China. METHODS From January to May 2010, we conducted a cross-sectional study in 2,498 participants aged above 30 years, residing in Gusu district of Suzhou. Serum soluble corin and blood pressure were measured. RESULTS Hypertensive participants had a higher level of serum corin than nonhypertensive participants (median (interquartile | [
-0.0076125935,
0.0071290466,
0.021720394,
-0.015329737,
-0.008494739,
0.017943503,
-0.020962402,
0.006834998,
-0.02098854,
-0.022857383,
-0.020622613,
0.007697541,
0.015787147,
0.0073773544,
-0.009416092,
-0.005449702,
0.04814557,
-0.0068284636,
0.0102198245,
-0.0075537837,
-0.02279204,
-0.0030483045,
0.006619362,
0.009782019,
-0.024543263,
0.03314255,
0.024556331,
-0.032253873,
0.0038291672,
-0.040016755,
-0.0017593912,
-0.002332786,
-0.025706388,
-0.0076648686,
-0.008174553,
-0.019028217,
0.0014326705,
0.0012154012,
0.008246431,
-0.025915489,
0.02692179,
0.005407228,
-0.0038945114,
-0.007958917,
0.002020768,
-0.028725287,
0.020504994,
-0.012774781,
-0.0030532053,
0.016153073,
0.028437773,
0.025209773,
0.0030973128,
-0.0063024433,
0.012258562,
-0.013192983,
-0.011461364,
0.015669527,
-0.013473963,
-0.028673012,
0.01083406,
0.006266504,
-0.032044772,
0.023550032,
-0.016453657,
-0.022347698,
-0.023824476,
0.008756116,
0.007390423,
0.011389486,
0.01776054,
0.035913143,
0.008586221,
0.017852021,
0.024883052,
-0.023719925,
-0.027836608,
-0.0037311509,
0.0060051274,
-0.0061978926,
0.0055215806,
-0.023536962,
-0.00090501644,
0.006880739,
0.009435695,
0.011441761,
-0.000028741215,
0.024869982,
-0.015447357,
-0.024451781,
-0.0040742075,
0.030319685,
-0.0018623082,
-0.00390758,
-0.00656382,
-0.0016858791,
0.0032966123,
0.028097983,
-0.019289592,
-0.0029029138,
-0.0023425878,
-0.025719456,
-0.011304538,
-0.012323907,
-0.035939284,
-0.0026529725,
0.001290547,
-0.02791502,
0.027078616,
0.0042081634,
-0.0029943956,
0.04221232,
-0.0011190185,
-0.02143288,
0.0020109662,
-0.017263925,
0.0078086257,
-0.005005362,
-0.0015919468,
-0.01038972,
0.011853429,
0.0012554245,
0.03740299,
-0.0009589254,
0.037481405,
0.019577106,
-0.01909356,
-0.016479794,
-0.000046838482,
-0.008285638,
-0.03207091,
0.030188996,
0.008677703,
0.027496818,
-0.01762985,
0.0005897309,
-0.0073642856,
-0.010664165,
-0.005877706,
-0.031626567,
-0.0037670902,
0.025327392,
-0.023380136,
-0.0064363987,
0.008991355,
0.042682797,
0.016884929,
0.011533243,
0.012866263,
0.00944223,
0.0073773544,
-0.009396489,
0.008488205,
0.010154481,
0.0007539081,
0.00068774715,
-0.017224718,
0.036671136,
-0.016558208,
-0.013983648,
0.0089194765,
0.0045414185,
0.01696334,
-0.01178155,
-0.003314582,
0.016728101,
0.011644327,
-0.0070898402,
-0.009657865,
-0.010357047,
0.0024994137,
0.025144428,
-0.02422961,
0.031992495,
0.030032171,
-0.012147477,
0.026072316,
-0.021681188,
0.0038651065,
-0.030058308,
-0.038239397,
0.024059715,
0.021354469,
0.008279104,
0.0017855288,
0.000053041073,
0.033011865,
-0.010618424,
0.0122716315,
-0.039258763,
-0.012990417,
0.01608773,
-0.0131080365,
-0.019145835,
-0.6465411,
-0.045923866,
-0.024268817,
-0.0049073454,
0.0065474836,
0.022726694,
0.012356578,
0.020844784,
-0.012742109,
0.020191342,
-0.0063971924,
0.01721165,
-0.012082133,
0.0015176178,
-0.01361772,
-0.041924804,
-0.0032982458,
0.0041493536,
0.0053484184,
0.0055705886,
-0.028359361,
0.0237722,
0.00028240925,
0.031234503,
0.009899639,
0.018949803,
0.0044205314,
-0.007971986,
-0.0065572853,
0.04937404,
0.0027934622,
0.011611655,
0.017224718,
0.009906173,
0.042186182,
-0.025327392,
-0.016871858,
0.019564038,
0.0028849442,
0.019773139,
-0.029352592,
-0.004975957,
0.020282824,
-0.0019521564,
-0.0077236784,
0.011807688,
0.0025549561,
-0.0045414185,
0.008462068,
-0.0029600898,
-0.005198127,
0.0063971924,
-0.011265331,
-0.024504056,
-0.017708264,
-0.0029698915,
-0.005387625,
-0.027339991,
0.0027297519,
-0.0058515687,
-0.017355407,
0.023066485,
-0.005158921,
0.0032753753,
0.009396489,
0.02042658,
-0.0173162,
0.015617251,
0.018400913,
0.0063710543,
0.005312479,
0.003763823,
-0.004240835,
-0.0155780455,
0.026647344,
0.022883521,
0.014127405,
0.014650159,
-0.023589239,
-0.00031140572,
-0.0053745564,
0.018570807,
0.013147242,
0.008181088,
0.015421219,
0.00046884426,
-0.033978958,
0.014663227,
-0.009991121,
-0.01909356,
0.01105623,
-0.010089137,
0.000711026,
-0.00020072906,
0.0061488845,
0.022308493,
-0.026268348,
0.008795323,
0.023981303,
-0.016022386,
-0.017263925,
-0.004172224,
-0.01178155,
-0.006456002,
0.0123173725,
-0.0010896137,
-0.022491455,
0.011304538,
0.04422492,
-0.026660413,
0.017015615,
-0.0047505195,
-0.024412574,
-0.021276055,
0.026059246,
-0.026581999,
0.0020175006,
-0.0017283527,
0.0021449216,
-0.017394612,
0.00360373,
-0.008194156,
0.0068742046,
0.007971986,
0.014846191,
0.00090501644,
0.010722975,
-0.010134878,
0.0029878612,
-0.034998327,
0.01821795,
-0.0078086257,
0.034658536,
0.010396254,
0.030790163,
-0.014166611,
0.0036331348,
0.0052504023,
0.011592052,
-0.0060541355,
-0.012193218,
-0.00441073,
-0.00223477,
-0.011088902,
-0.0019848286,
-0.0074426983,
-0.00993231,
-0.012591817,
-0.010932076,
-0.027888883,
0.010121808,
-0.026843376,
-0.009834294,
0.008899873,
-0.01496381,
0.0017610248,
-0.005371289,
-0.01451947,
-0.014898466,
-0.011690068,
0.020008378,
-0.0078086257,
-0.051099125,
0.020178273,
0.008213759,
-0.026399037,
-0.004283309,
0.012134409,
-0.020727163,
-0.029326454,
0.0018655754,
-0.01440185,
0.00032508714,
0.020923197,
-0.0074688364,
0.0010887969,
-0.027601369,
0.009278869,
-0.02422961,
-0.018139536,
0.01730313,
-0.018623082,
-0.034658536,
-0.020413512,
0.023811407,
0.0059169126,
0.02366765,
-0.0055771233,
0.014846191,
0.02924804,
-0.021694258,
0.02166812,
-0.039859932,
0.017041754,
0.004028467,
-0.031469744,
0.0021089823,
-0.012369648,
0.021027748,
0.012644093,
0.024033578,
-0.018100329,
-0.0033652238,
-0.026268348,
0.016701965,
-0.009808157,
0.0008813292,
-0.014715502,
0.020518063,
0.015761008,
0.023314793,
-0.0119449105,
-0.021380605,
-0.021916427,
0.0109190075,
0.008625427,
-0.005243868,
-0.011964514,
-0.0050935764,
0.003401163,
0.0016973143,
0.016662758,
0.009501039,
0.010840594,
-0.033691444,
0.010089137,
0.039389454,
0.031626567,
0.0031773592,
-0.0086384965,
-0.03818712,
-0.00037450367,
0.017512232,
-0.004861605,
-0.014989948,
-0.0027673247,
0.01708096,
-0.037481405,
-0.0061521516,
0.037246164,
0.0070767715,
0.006429864,
0.001834537,
-0.015813284,
0.009115509,
-0.020413512,
0.013258328,
0.020805577,
0.0011508738,
0.027732057,
0.018936735,
0.0059103784,
-0.014937673,
-0.015316669,
-0.010886335,
-0.0016760774,
-0.010729509,
0.012702903,
0.036671136,
0.022269286,
0.04320555,
0.0078020915,
0.012748644,
-0.00094749016,
0.0029992964,
0.015970109,
0.006802326,
-0.018400913,
-0.013134174,
0.0030107317,
-0.01121959,
-0.009206991,
0.020178273,
-0.053529926,
0.01888446,
-0.003606997,
0.0011974315,
0.003982726,
0.013101501,
0.005792759,
-0.035390392,
-0.015159843,
0.0023262517,
0.019002078,
-0.0007330797,
-0.007606059,
-0.0102198245,
0.0009793454,
-0.022857383,
0.039154213,
0.003796495,
0.0015266027,
0.005590192,
-0.023550032,
0.0015192515,
-0.00081026746,
-0.0025712922,
0.008788788,
0.02042658,
0.0011206522,
-0.02098854,
-0.003206764,
-0.023288654,
-0.0138529595,
0.047073923,
0.019773139,
0.012186684,
0.007854367,
0.016466726,
-0.0006803959,
-0.0011729274,
-0.007004893,
-0.019420281,
0.0143626435,
0.010788319,
0.01295121,
0.009912707,
0.013042692,
0.0145978825,
-0.014035923,
-0.0105922865,
-0.03975538,
-0.02345855,
-0.023915958,
0.049191076,
0.03829167,
0.0002636228,
0.014989948,
0.022243148,
0.013395551,
-0.023184104,
-0.035991557,
0.011494036,
0.0053320825,
-0.012905469,
-0.016218418,
0.022596007,
-0.0064200624,
-0.00737082,
0.005501977,
0.001533137,
-0.022034047,
0.019825414,
0.0061586862,
-0.0041036126,
0.0039304504,
0.03920649,
0.049321763,
0.026124591,
-0.005858103,
0.009389955,
0.033586893,
0.0076518,
0.009775485,
-0.011193452,
0.019668588,
-0.010807922,
0.0010112007,
-0.021210711,
-0.0031610231,
-0.0050870418,
0.0017757273,
0.011088902,
0.0048420015,
0.0145978825,
0.030424235,
0.014558677,
0.018387843,
-0.00787397,
-0.023641514,
0.03139133,
-0.0007408393,
-0.0005672689,
-0.0029747924,
0.014937673,
0.0005542001,
0.021838015,
-0.02379834,
0.0037246165,
-0.01875377,
-0.006629164,
-0.0067892573,
-0.017394612,
-0.008978286,
-0.011415623,
-0.023628443,
0.019511763,
-0.011650862,
-0.015238255,
-0.012996951,
-0.012624489,
-0.01887139,
-0.00714865,
0.026974065,
0.028437773,
-0.012761712,
-0.0089194765,
0.039650828,
-0.0024504056,
0.00848167,
0.007906642,
-0.01877991,
0.01383989,
0.009625193,
-0.006080273,
-0.014532539,
0.008560084,
-0.01696334,
0.009984586,
-0.00019654295,
-0.009795088,
-0.0020844783,
-0.007782488,
-0.0033211163,
0.010428926,
-0.027705919,
0.028568462,
-0.010252497,
0.009135112,
-0.005652269,
0.016741171,
0.009200457,
-0.023576168,
-0.015068361,
0.0063449168,
-0.04623752,
-0.009135112,
-0.020622613,
0.01696334,
-0.0048125964,
0.0027934622,
0.0073185447,
-0.003950054,
-0.012297769,
0.018858321,
-0.021877222,
0.008141881,
0.008533946,
0.012715971,
-0.001834537,
-0.00045005782,
0.028751425,
0.018975941,
-0.025771732,
-0.0101283435,
0.016179211,
0.014166611,
-0.0022854116,
-0.037821192,
-0.0021792273,
0.00007948503,
-0.020701027,
-0.043911267,
-0.004920414,
-0.015721802,
0.016048523,
-0.008841063,
-0.024765432,
-0.03761209,
-0.0045479527,
-0.003943519,
-0.0009679102,
0.009461833,
-0.008749582,
-0.02144595,
-0.011814222,
-0.0016238021,
-0.017276993,
0.024660882,
-0.028516186,
-0.011912238,
-0.0014367545,
0.00020511937,
-0.011840359,
-0.0089194765,
-0.0100368615,
-0.006456002,
0.008899873,
-0.010363582,
-0.007292407,
-0.025105221,
-0.0070833056,
0.026111523,
-0.0019799278,
0.032802764,
0.022034047,
0.014166611,
0.02501374,
0.021811876,
0.006171755,
-0.022922728,
0.008494739,
-0.013996717,
0.029221904,
0.0038226326,
0.008135347,
0.01808726,
0.0011198353,
0.00032243255,
0.018034985,
-0.0037148148,
-0.024098922,
-0.009919242,
-0.021589708,
-0.0064069936,
-0.001319135,
-0.0018672091,
0.008756116,
-0.023955164,
-0.019564038,
0.019472556,
-0.017682126,
-0.0015020986,
-0.030528786,
0.015682595,
-0.022988072,
0.030999264,
-0.026895652,
0.024098922,
0.003136519,
0.0037115477,
0.0063514514,
0.023380136,
0.025431942,
-0.023968235,
0.0061586862,
0.014885397,
-0.0049530864,
-0.013395551,
-0.0022870451,
-0.033743717,
-0.01361772,
0.0056751394,
-0.0018655754,
0.012519939,
-0.019158904,
-0.010102205,
-0.01808726,
-0.006991824,
0.018518532,
-0.02300114,
0.03978152,
-0.012820522,
0.0038487704,
-0.013696133,
-0.0008560083,
0.02869915,
-0.004567556,
0.05452316,
0.02523591,
-0.022478387,
-0.012683299,
0.0011361714,
0.010638027,
-0.005201394,
0.01608773,
0.027941158,
-0.036697272,
-0.009873501,
-0.006286107,
0.020400444,
-0.021197641,
-0.023327861,
0.03797802,
0.014820053,
0.02492226,
-0.013153777,
-0.0076125935,
-0.018061122,
-0.009291938,
-0.011409088,
-0.029117353,
0.007560318,
-0.02111923,
-0.0017332536,
0.007887038,
-0.0016499398,
0.011585518,
0.027705919,
-0.046472758,
-0.0049334834,
-0.00089194765,
-0.004711313,
-0.003309681,
0.03371758,
0.021014677,
-0.019158904,
0.0031152824,
0.0050478354,
0.012336975,
0.01049427,
0.009206991,
-0.03787347,
0.042395283,
-0.0021465553,
-0.018270224,
0.010141412,
-0.005747018,
0.023445481,
-0.008011193,
-0.013473963,
-0.03515515,
-0.013003485,
0.008024261,
0.039807655,
0.02625528,
-0.025431942,
0.022034047,
-0.017407682,
-0.0038389687,
-0.026712688,
-0.016937204,
-0.008442464,
-0.02726158,
-0.0117096715,
0.003071175,
-0.01986462,
0.031548154,
0.010755647,
-0.0030744423,
0.0065017426,
0.0089652175,
-0.011213056,
0.014388782,
-0.011075833,
0.009122043,
-0.03319483,
0.030215135,
-0.031234503,
-0.007867436,
0.003512248,
-0.00027362863,
0.0014392049,
-0.023994371,
0.006632431,
0.015591114,
0.0030597397,
-0.0017201847,
0.034109645,
0.0026905453,
-0.004806062,
0.00737082,
0.016793447,
0.009782019,
-0.022060184,
0.003747487,
0.015368944,
-0.01919811,
0.019237317,
-0.0097101405,
-0.0023099156,
0.0020501728,
-0.01574794,
-0.030528786,
-0.029640106,
0.01762985,
-0.007338148,
0.0084032575,
-0.02334093,
-0.018701496,
-0.018949803,
0.035442665,
-0.016728101,
-0.008200691,
0.005649002,
0.006978755,
0.018949803,
0.008056934,
-0.018688427,
0.0023719927,
0.004619831,
-0.0049498193,
-0.021916427,
0.008070002,
0.0014465561,
0.021641983,
0.01004993,
-0.007070237,
-0.027392266,
-0.0046917098,
-0.049766105,
-0.019590177,
0.00038246746,
0.030842438,
-0.010010724,
-0.009076302,
0.009553314,
0.024111992,
-0.0007142932,
0.012892401,
-0.028124122,
-0.011284934,
0.012010255,
-0.024752364,
0.04446016,
0.0017838953,
-0.021393673,
-0.004283309,
0.019524831,
-0.012533008,
-0.0051850583,
0.031992495,
0.0022315027,
0.023393204,
-0.019851552,
0.0072401315,
0.004476074,
-0.03729844,
0.0055869245,
-0.018244086,
0.0011786451,
0.009971517,
-0.006325314,
0.010722975,
0.010932076,
-0.0027771264,
0.007743282,
-0.016153073,
0.0045479527,
-0.054575432,
0.015368944,
-0.005462771,
0.010409323,
0.0035220496,
-0.0024308024,
0.01373534,
0.018662289,
-0.0072728037,
-0.019799277,
0.00055705884,
0.009331144,
-0.01518598,
0.0077236784,
0.001842705,
-0.013918304,
-0.016375244,
0.0066389656,
-0.019237317,
-0.012807453,
-0.004776657,
-0.013866029,
-0.0058679045,
0.021628913,
0.015094498,
-0.007854367,
0.004711313,
0.0019178508,
-0.035991557,
0.003574325,
0.0063024433,
-0.02066182,
-0.010428926,
-0.008285638,
0.0022282354,
0.013304069,
-0.0069983583,
-0.03416192,
0.0044499366,
-0.0069330144,
0.014584814,
0.20701027,
-0.0015992981,
0.003871641,
0.0370632,
-0.0030058308,
0.0029617236,
-0.0026415372,
0.023027278,
0.00040962614,
0.019956103,
-0.00021604409,
-0.010683768,
-0.0030450374,
0.0075995247,
0.014767777,
-0.027993433,
-0.011017024,
-0.009677469,
0.008037331,
-0.004675374,
0.008148415,
0.00086580997,
-0.005211196,
0.0035416528,
0.022909658,
-0.009814691,
0.000003854284,
-0.014950741,
0.023053415,
0.0023670918,
-0.008324845,
0.032332286,
0.019263456,
0.017394612,
-0.014048992,
-0.0023997638,
0.008560084,
0.004028467,
0.0062763053,
-0.00600186,
-0.03126064,
-0.009788553,
-0.022805108,
0.0011525074,
0.013049226,
0.020504994,
-0.0030564726,
0.004770123,
-0.012657162,
0.017499164,
-0.04558408,
0.0183225,
0.015591114,
0.024856914,
-0.018061122,
0.0050968435,
0.018727632,
0.014192749,
-0.008168018,
0.006410261,
0.00809614,
0.003606997,
0.019224249,
0.028542325,
-0.04265666,
0.011343745,
-0.023197172,
-0.008494739,
0.0012946309,
-0.011729275,
-0.0023099156,
-0.03842236,
-0.016022386,
0.023079554,
-0.0044630053,
0.0048485356,
0.02736613,
0.024177335,
0.017904297,
0.022413043,
0.030215135,
0.0064069936,
-0.011062765,
0.0072662695,
-0.02702634,
-0.0388667,
-0.0073773544,
0.009337679,
-0.012291234,
-0.023484686,
-0.0032835435,
-0.01189917,
0.010794854,
-0.040617924,
0.025810938,
-0.008285638,
-0.017943503,
-0.0069852895,
-0.010252497,
-0.0037703575,
0.0028016304,
0.06680786,
-0.005103378,
0.014506401,
-0.016179211,
-0.017538369,
-0.028202534,
0.007965452,
0.011494036,
0.0108275255,
-0.0022788772,
-0.033560757,
-0.0059169126,
-0.01585249,
-0.0041068797,
0.01629683,
0.039494004,
-0.029352592,
0.016466726,
-0.021498226,
-0.010154481,
-0.03617452,
-0.004110147,
0.031234503,
0.0032083977,
-0.006426597,
0.005309212,
0.0043682563,
-0.028960526,
-0.036723413,
0.021171505,
-0.008625427,
0.0005656353,
-0.0077563506,
0.019786209,
0.005747018,
-0.010193687,
0.0010332543,
0.004616564,
-0.0018329034,
-0.0044630053,
-0.029587831,
-0.0022984804,
-0.00079679023,
0.02523591,
0.03829167,
0.0006215862,
0.021171505,
0.0025222842,
0.001063476,
0.002313183,
0.0030205334,
0.008756116,
0.0039631226,
0.026333692,
-0.035338115,
-0.022975003,
-0.015917834,
0.011350279,
0.0046492363,
0.005796026,
-0.0009164517,
0.0000673351,
-0.00390758,
-0.005243868,
0.0020142335,
-0.16424905,
0.017067892,
0.027444543,
-0.011311072,
-0.0012186684,
0.013212587,
-0.0025124825,
-0.003388094,
0.020897059,
0.010722975,
0.024530193,
-0.023915958,
-0.0091024395,
-0.02590242,
0.0027836608,
0.0043029124,
-0.0032018633,
0.024347229,
0.039859932,
0.016505932,
0.02523591,
-0.012232425,
0.01696334,
-0.022961933,
0.013277931,
0.019629382,
0.017159373,
0.017446889,
-0.009964983,
-0.0019113163,
-0.0011002321,
-0.0059201797,
0.013683065,
-0.012585283,
-0.016453657,
-0.0044139973,
-0.0068415324,
-0.013317138,
-0.0017316199,
0.011670465,
0.02378527,
0.026399037,
-0.01395751,
0.018740702,
-0.031992495,
0.035390392,
0.008390189,
-0.014833122,
0.02713089,
-0.025536492,
0.018440118,
-0.028777564,
0.042186182,
0.033795994,
-0.008729978,
0.010814456,
-0.0015339539,
-0.0059953257,
0.0049530864,
0.016113868,
-0.01619228,
0.004080742,
0.038134847,
0.006723913,
0.01765599,
-0.012663696,
0.008749582,
0.010455064,
-0.027758194,
0.027183166,
-0.022818176,
-0.0155780455,
0.017250855,
-0.014833122,
0.018792978,
0.012755178,
0.005848301,
0.019590177,
-0.00033836017,
0.00054929923,
-0.01955097,
0.0043976614,
-0.025980834,
-0.029091215,
-0.010206756,
0.028646875,
0.02042658,
0.005541184,
0.011487502,
-0.023602307,
0.0225568,
-0.029457143,
-0.01244806,
-0.002613766,
0.0075211115,
0.0015511067,
0.0022151666,
0.02077944,
-0.005015163,
-0.013212587,
0.022190873,
-0.016048523,
0.005890775,
-0.0063906577,
0.029221904,
-0.006524613,
0.0029878612,
0.0024912457,
0.014584814,
-0.03361303,
0.011578983,
0.002126952,
-0.0019766605,
0.027627505,
-0.0150160855,
0.033534616,
0.0040676733,
-0.017224718,
0.0012611421,
-0.018662289,
0.04333624,
-0.016113868,
0.02009986,
0.010259031,
-0.022765901,
-0.026895652,
-0.09812077,
-0.00050927594,
0.01441492,
0.02289659,
0.009128578,
0.032776624,
-0.015721802,
0.03306414,
-0.011611655,
0.026791101,
0.0030303348,
0.004479341,
-0.004489143,
-0.0035253167,
0.03439716,
0.0036167987,
-0.012676765,
-0.016911065,
-0.019773139,
0.0031071142,
-0.0038226326,
-0.020648751,
0.019472556,
-0.0063547185,
0.003512248,
0.008187622,
-0.034553986,
0.022909658,
0.004959621,
0.014035923,
0.016688896,
0.009997655,
-0.009252732,
0.0013215854,
-0.021485155,
-0.020897059,
-0.016257625,
-0.025183635,
0.02390289,
-0.004489143,
0.007704075,
0.02223008,
0.034449436,
-0.021053884,
-0.008677703,
-0.00006789665,
-0.024556331,
0.0044205314,
0.010749113,
-0.030764025,
0.00041330175,
-0.0093834195,
-0.0111999875,
-0.016113868,
0.006629164,
-0.012748644,
-0.011173849,
0.012212821,
-0.030868575,
-0.011938376,
-0.006050868,
0.0026921788,
-0.015734872,
0.0035873938,
0.026229141,
-0.01787816,
-0.007102909,
-0.028855976,
0.01206253,
-0.044041958,
-0.021968704,
0.002167792,
-0.012310837,
0.005939783,
-0.02166812,
0.0024765432,
-0.011840359,
0.0010740944,
0.026216073,
-0.010958213,
-0.0225568,
-0.0026774765,
0.007736747,
-0.04660345,
0.0061946255,
-0.0026333693,
-0.010121808,
-0.0052340664,
0.02702634,
-0.028385498,
-0.016009316,
0.022831246,
0.0065148114,
0.0001358954,
0.019681657,
0.011977582,
0.0101740835,
-0.021472087,
0.018113399,
-0.005890775,
-0.02243918,
-0.0089652175,
-0.058809735,
0.013539308,
0.029091215,
0.009213525,
-0.006681439,
-0.030058308,
0.018479325,
0.009246197,
0.0006252618,
-0.017107097,
-0.019668588,
0.00024422375,
-0.006534415,
-0.024556331,
-0.029770793,
-0.0059659206,
0.029692382,
0.0078020915,
0.046498895,
0.0064625363,
-0.0011100337,
0.0183225,
0.007070237,
0.02914349,
0.0067957914,
0.006266504,
0.020975472,
-0.0057241474,
-0.00686767,
-0.0126898335,
0.01808726,
-0.025993902,
-0.021210711,
0.020753302,
-0.0051425844,
-0.026399037,
0.006599759,
0.033560757,
0.0045577544,
0.000090613954,
-0.020491924,
-0.004361722,
0.012160546,
0.0082595,
0.003306414,
0.014375713,
-0.021981772,
0.0245694,
0.020374306,
-0.030398099,
0.016362175,
0.0064331316,
-0.00876265,
-0.027183166,
-0.020086791,
0.0041983617,
0.0022821445,
0.011441761,
0.001756124,
-0.019929966,
0.017355407,
0.0063971924,
-0.00027485384,
0.0014588081,
0.029535554,
-0.014976879,
-0.02723544,
-0.032227736,
0.028751425,
-0.006567087,
-0.0031610231,
-0.025732527,
-0.00082333625,
-0.016153073,
-0.0011565915,
0.004280042,
-0.007834763,
0.0023964967,
-0.008514343,
0.011873032,
-0.0067500505,
0.012676765,
-0.024830777,
0.010651097,
0.018257156,
0.0005284708,
0.0076321964,
0.020609545,
-0.009625193,
0.002505948,
-0.0028457376,
0.0003990077,
-0.011141177,
0.0013248526,
0.021485155,
0.05447088,
-0.017486094,
0.0068938076,
0.028855976,
0.005593459,
0.011343745,
0.011369882,
-0.0237722,
-0.039650828,
-0.023915958,
-0.014101267,
-0.006472338,
-0.03452785,
-0.013787615,
-0.0075341803,
0.0062893745,
-0.0026856444,
-0.005198127,
-0.00085192436,
0.008011193,
-0.006233832,
-0.014153543,
0.011598586,
-0.012559146,
0.024085853,
-0.016479794,
0.0003985993,
0.016597414,
0.012049461,
0.004580625,
0.013591583,
0.023746064,
0.010507339,
0.024608606,
-0.00982776,
0.007481905,
-0.00888027,
-0.026764963,
-0.0016401381,
-0.0044826088,
-0.01719858,
0.01451947,
0.01708096,
0.012879332,
0.056195967,
-0.015839422,
-0.02903894,
-0.004237568,
-0.0032018633,
0.009703606,
-0.008716909,
0.025248978,
-0.031182228,
-0.00848167,
-0.0036396692,
-0.033247102,
0.00040819673,
-0.03873601,
-0.02492226,
0.030136721,
-0.0007093924,
-0.0048942766,
-0.011964514,
-0.012964279,
0.013774547,
-0.012715971,
0.007828229,
-0.0002244163,
-0.033351652,
-0.0076714032,
0.024987603,
-0.0052667386,
-0.006361253,
-0.020008378,
-0.00893908,
0.01574794,
-0.024216542,
-0.020531131,
0.028960526,
-0.009226594,
-0.0019635917,
-0.01909356,
0.005341884,
-0.007926245,
-0.014793916,
0.0033031467,
-0.0149246035,
0.008566618,
-0.020570338,
0.00972321,
-0.03536425,
-0.03382213,
-0.005214463
] |
BACKGROUND Two inflammatory disorders, type 1 diabetes and celiac disease, cosegregate in populations, suggesting a common genetic origin. Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared. METHODS We evaluated the association between type 1 diabetes and eight loci related to the risk of celiac disease by genotyping and statistical analyses of DNA samples from 8064 patients with type 1 diabetes, 9339 control subjects, and 2828 families providing 3064 parent-child trios (consisting of an affected child and both biologic parents | [
-0.015026742,
0.007135093,
0.035897214,
-0.031383976,
-0.02791426,
0.018431237,
-0.007206836,
0.009828689,
-0.008693857,
-0.014413672,
-0.016539851,
-0.0072198794,
0.010141746,
0.0069198664,
-0.0010443389,
0.030601332,
0.043332323,
-0.015809383,
0.0028093616,
0.014387583,
-0.04200183,
0.012365756,
0.022592288,
-0.021861821,
-0.0062546204,
0.031566594,
0.0054524112,
-0.019331276,
-0.016709423,
-0.018522546,
0.017348582,
0.0066915955,
-0.02434019,
0.009789557,
-0.0060491767,
-0.028931694,
0.017022481,
0.0024783688,
0.015339798,
-0.012020089,
0.0022794472,
0.0026153312,
-0.0041740946,
-0.009841733,
0.0024588027,
0.019670421,
0.0020120442,
0.0031501371,
-0.010643941,
0.008837341,
0.0037697293,
0.0236619,
-0.022409672,
-0.006776382,
-0.017322494,
-0.003101222,
0.036288537,
-0.0023544503,
-0.0017462717,
-0.0313318,
-0.0073959744,
0.011811384,
-0.024718467,
-0.015835471,
-0.011270056,
0.0016647464,
0.001834319,
0.017413802,
0.02072699,
0.003075134,
0.036992915,
0.023218403,
0.0016443651,
-0.009554764,
0.033705816,
-0.011524415,
0.008922128,
-0.001476423,
-0.0014397366,
0.009867821,
0.015039786,
-0.015170226,
0.01721814,
0.026557678,
0.007663377,
-0.012287492,
-0.0034762383,
0.007343798,
-0.027027264,
-0.018105136,
-0.013370147,
-0.0049632597,
-0.00068522006,
0.011126571,
-0.00483608,
0.0018734512,
0.024053222,
0.036132008,
-0.009685204,
-0.015913736,
-0.0055371975,
0.011857038,
-0.016513763,
-0.0141658345,
-0.018679075,
0.0028892562,
0.0073894523,
-0.007617723,
0.0046567246,
-0.021222664,
-0.01991826,
0.026505502,
0.0029218663,
-0.009352582,
0.005967651,
-0.031201359,
0.014752816,
-0.005618723,
-0.015091961,
-0.01921388,
0.023909736,
0.017831212,
0.006492674,
-0.02040089,
0.008563416,
0.013239707,
-0.034227576,
0.0066068093,
-0.015809383,
-0.00886343,
0.0010370017,
0.02044002,
0.014948477,
-0.0035936348,
-0.03130571,
-0.000422301,
-0.024927173,
-0.013337538,
-0.014674552,
-0.007356842,
0.008263404,
0.029323015,
-0.017765991,
0.0015163703,
0.00841341,
0.035036307,
0.02611418,
0.0095808515,
-0.010976565,
0.004506718,
-0.0100634815,
0.0015758838,
0.010050437,
0.0093460595,
0.027314233,
0.018613854,
-0.0026348974,
0.017126832,
-0.023087962,
-0.023296667,
-0.015078917,
-0.019409541,
-0.004431715,
0.022735773,
0.0063948436,
0.033679727,
-0.00079405634,
-0.042836647,
0.008882996,
0.0061078747,
-0.029662162,
0.012254882,
-0.01798774,
0.0077742515,
-0.0036914651,
-0.005625245,
-0.009587374,
0.0069068223,
-0.030549156,
-0.028488196,
-0.022044439,
0.021457456,
0.019813906,
-0.001995739,
-0.02173138,
0.0013940824,
0.021992262,
0.02620549,
-0.006965521,
-0.024222793,
-0.001479684,
0.0049404325,
0.009619984,
-0.024509763,
-0.6478195,
-0.024444543,
0.028618637,
-0.017518153,
-0.024457587,
0.040280014,
0.01743989,
0.018705163,
-0.02105309,
0.010343929,
0.0004161866,
0.037305973,
0.011426585,
-0.019526938,
-0.016018089,
-0.042080093,
0.0125940265,
-0.019044308,
0.034358017,
0.006212227,
-0.0111461375,
-0.0020218273,
0.007506849,
0.0019614985,
0.0016288753,
0.023674944,
0.022944478,
-0.022814037,
0.005889387,
0.028827343,
-0.030027395,
0.006492674,
-0.0014438129,
0.019735642,
0.056402456,
-0.011759208,
-0.0015530568,
0.008472108,
0.0064046266,
0.029323015,
-0.01886169,
-0.015809383,
0.02488804,
0.02304883,
-0.0058763428,
0.023153182,
0.0022549895,
0.023257535,
0.02392278,
-0.014478891,
-0.007663377,
0.00860907,
-0.014948477,
-0.02407931,
0.032036178,
-0.015978957,
0.03250576,
-0.017661639,
0.018652987,
0.0005189085,
-0.014139746,
0.030001307,
-0.011602679,
-0.0059970003,
-0.0057100314,
-0.025409803,
-0.0026740294,
0.006808992,
0.0030327407,
0.019187791,
0.010467847,
0.0357146,
-0.0043534506,
0.011296144,
0.0392104,
0.018705163,
0.009078656,
0.03704509,
-0.02898387,
0.0119940005,
-0.017022481,
-0.0022028133,
-0.0063491897,
0.0068546464,
0.02291839,
-0.0048654294,
-0.010611332,
0.032218795,
-0.032323148,
0.006991609,
0.011354842,
0.014948477,
-0.021561809,
-0.029609986,
-0.029375192,
0.03284491,
-0.022448804,
0.014257142,
0.015678944,
-0.021131355,
-0.0029414324,
-0.03250576,
-0.008432976,
-0.008811253,
0.014387583,
0.009919997,
-0.03250576,
0.023557547,
0.04241924,
-0.018783426,
0.004053437,
-0.0098221665,
-0.028775167,
-0.011107005,
0.02843602,
-0.017126832,
-0.012841864,
0.0061600506,
0.0005462194,
-0.020035654,
0.0145702,
0.0030523068,
0.0052306624,
-0.017883388,
-0.009111267,
0.015157182,
-0.023583636,
-0.02243576,
0.014061482,
-0.013331016,
-0.0111461375,
0.0021653117,
0.009391713,
-0.017779035,
0.00473825,
-0.019866083,
0.019709554,
0.0046665077,
-0.011093961,
-0.03597548,
-0.020348713,
-0.005974173,
0.008263404,
0.00902648,
0.00428823,
0.021835733,
-0.0051784865,
-0.014257142,
0.0038056006,
-0.0015277839,
0.036992915,
-0.0012212489,
-0.020531328,
0.008785165,
-0.008648203,
-0.000058800117,
0.01076786,
-0.01908344,
0.011022219,
-0.022227054,
0.025540242,
0.009861299,
0.0069263885,
-0.005308927,
-0.0111461375,
-0.005302405,
-0.0034403673,
0.037801646,
-0.017531198,
-0.015652856,
0.004826297,
-0.007311188,
-0.012665769,
0.033184055,
0.001131571,
0.0066263755,
0.004594765,
-0.009685204,
0.0041186577,
-0.007030741,
-0.01901822,
-0.02385756,
-0.0048654294,
0.012072265,
0.036340714,
0.0004023273,
0.020648725,
-0.002995239,
-0.0064763688,
0.02955781,
-0.01730945,
0.011107005,
-0.022318363,
0.018013828,
-0.00013981586,
0.019448673,
-0.008693857,
-0.0045751994,
-0.0074090185,
-0.0008168834,
0.016852908,
-0.030888302,
0.013983218,
-0.024796732,
0.031514417,
-0.051054396,
-0.0038056006,
-0.021600941,
0.025840256,
0.018235577,
0.0026642464,
-0.0156659,
0.0037240752,
0.0023120572,
0.02162703,
0.03477543,
-0.016265925,
-0.004584982,
0.016435498,
-0.0013900062,
0.014309319,
0.020753078,
0.038662553,
-0.003213727,
-0.009365626,
0.012215749,
0.011530937,
0.00812644,
-0.014726728,
-0.02749685,
-0.007806862,
0.003984956,
0.015457195,
0.010128702,
0.0021881387,
0.0022794472,
0.009854777,
-0.0021979217,
0.016187662,
0.024066266,
-0.0010818406,
0.002411518,
0.004989348,
0.011857038,
-0.022031395,
-0.0023935826,
0.0077677295,
-0.0010883627,
-0.025409803,
0.037123356,
0.0046208533,
0.00069296494,
-0.0065774606,
-0.018548634,
0.010004783,
-0.0060524377,
0.011974434,
0.0015122942,
0.038740817,
0.0236619,
0.009261273,
-0.0060230885,
-0.009561286,
0.008596026,
-0.0030164358,
-0.009854777,
-0.008530806,
-0.012026611,
-0.010709162,
0.007356842,
-0.04635854,
-0.011707031,
0.011661378,
-0.01008957,
-0.0018913867,
0.026335929,
0.012848386,
-0.014126702,
0.027183792,
-0.0052339234,
-0.002817514,
-0.016435498,
0.032349236,
0.036679856,
0.0012571199,
-0.014400627,
-0.0023087962,
0.017674683,
-0.0076959874,
0.0035381976,
0.006998131,
0.018300798,
0.033731904,
0.002639789,
0.021705292,
0.005348059,
0.039262578,
-0.01183095,
0.00544915,
0.0139179975,
-0.0060850475,
0.0072329235,
-0.021848777,
0.0020886778,
0.03391452,
0.020687858,
0.0007149768,
-0.01067003,
-0.0022843387,
-0.022670552,
0.014270186,
-0.01244402,
0.0034827604,
0.0070829173,
0.00023744241,
0.014948477,
0.0002250098,
0.024222793,
0.01421801,
-0.013787557,
-0.010630898,
-0.058332976,
-0.021287883,
0.009430845,
0.010950477,
0.0141658345,
-0.018992132,
0.007826428,
-0.002916975,
0.013239707,
-0.008243837,
-0.024574984,
0.023974957,
-0.0020218273,
-0.016422454,
0.0034273232,
0.030575244,
0.008146007,
0.012307058,
0.01134832,
-0.00499587,
-0.023635812,
-0.000064201166,
0.026231578,
0.0069003003,
-0.0067111617,
0.023140138,
0.027835995,
0.03722771,
-0.03227097,
0.011902692,
0.019787818,
-0.0016777904,
0.00367516,
-0.03665377,
0.021327015,
0.0072459676,
0.02898387,
-0.007976434,
-0.0022582505,
0.023753209,
-0.0067829043,
0.009196052,
-0.0061633117,
0.022227054,
0.00008896447,
0.014974565,
0.015939824,
-0.019539982,
-0.0049078222,
-0.013565809,
0.025905475,
-0.009828689,
-0.008191661,
0.02550111,
-0.020061743,
0.026335929,
-0.03443628,
0.023296667,
-0.011589635,
-0.020453064,
-0.0156659,
-0.00960694,
-0.005380669,
0.00783295,
-0.013220141,
0.0033099267,
0.003949085,
-0.024718467,
-0.009137355,
-0.027731642,
-0.020609593,
-0.02611418,
-0.014309319,
0.0064013656,
-0.020113919,
-0.004001261,
-0.018848646,
0.023609724,
-0.0021424845,
0.005837211,
0.012222271,
0.016539851,
0.020035654,
-0.012117919,
-0.0074024964,
0.011413541,
-0.012750555,
0.009483022,
0.00024437206,
0.015522415,
0.007115527,
-0.014674552,
0.011517893,
-0.015744165,
-0.015522415,
0.005517632,
0.008152529,
-0.0057948176,
-0.0034794994,
0.008243837,
0.023427106,
-0.012359234,
-0.018326884,
-0.021170488,
-0.02291839,
-0.03430584,
-0.01592678,
0.003939302,
-0.025801124,
-0.006130702,
-0.011791818,
0.010233054,
-0.020700902,
0.015457195,
-0.008035133,
-0.0014862061,
0.004676291,
0.014896301,
0.036001567,
-0.007982956,
-0.0063883215,
0.014531068,
-0.0108983,
-0.0043371455,
-0.0022712946,
0.015026742,
-0.02092265,
-0.012430976,
0.019318232,
0.014335407,
-0.020583505,
-0.014752816,
-0.021874866,
-0.020453064,
0.040019132,
-0.0015098484,
0.00905909,
-0.0070111747,
0.0060328715,
-0.0011609201,
0.020140007,
-0.008406888,
-0.001992478,
-0.0028647988,
-0.003365364,
-0.010448281,
-0.021613985,
0.0057035093,
-0.03487978,
-0.025957651,
0.017870344,
-0.012652725,
0.027235968,
0.0086155925,
0.0068546464,
0.00017456603,
-0.021027002,
0.003681682,
-0.010076526,
0.008726467,
-0.015522415,
0.029714337,
0.025670683,
0.025696771,
-0.011733119,
0.031227447,
0.0123788,
0.022461848,
0.024001045,
-0.024927173,
0.023466239,
-0.022683596,
-0.014674552,
0.0057817735,
0.016435498,
0.0021702033,
-0.003919736,
0.009913475,
0.023674944,
-0.02214879,
-0.02162703,
-0.007356842,
-0.054211058,
-0.007911214,
-0.007135093,
-0.00280447,
0.02598374,
-0.023492327,
-0.004604548,
0.027862083,
-0.015287622,
0.013409279,
-0.008041655,
0.024353234,
-0.016800731,
0.04085395,
0.0040958305,
0.014478891,
-0.009352582,
-0.03378408,
-0.0027604464,
-0.0059383023,
0.012437498,
0.0167616,
0.020413933,
-0.0020055221,
-0.010917867,
-0.00040110442,
0.018261665,
-0.03819297,
-0.0030131747,
-0.030575244,
-0.012515763,
0.009280839,
-0.010500457,
-0.016983349,
-0.014935433,
0.017335538,
-0.013461456,
-0.023466239,
0.022253143,
-0.0005507033,
-0.018913867,
-0.0071937917,
0.019787818,
0.024914129,
-0.025201097,
0.008909084,
0.013096223,
-0.01176573,
-0.026075048,
0.012124441,
0.020100875,
-0.0029316493,
0.04171486,
0.017426847,
-0.0049013,
-0.009404757,
0.020896561,
-0.0041284407,
0.012509241,
-0.042523593,
0.0015881127,
0.01134832,
0.010363495,
-0.013735381,
-0.008472108,
-0.023166226,
-0.0016492566,
-0.0017837733,
0.01837906,
-0.013083179,
-0.014583244,
0.0013003284,
0.022383584,
-0.015548503,
0.030183922,
-0.0002773898,
-0.025996784,
-0.002721314,
-0.03803644,
-0.007950346,
-0.0031289407,
0.023127094,
0.02604896,
-0.010056959,
0.0040143053,
-0.0052404455,
-0.009287361,
0.0031452456,
-0.006795948,
-0.018013828,
0.034671076,
-0.018731251,
0.002250098,
0.004523023,
0.007422062,
-0.0028158836,
0.0049208663,
-0.005377408,
-0.0024164096,
-0.02537067,
-0.022174878,
0.027862083,
0.001631321,
0.0041643116,
0.0066459416,
-0.026153313,
0.0023218403,
-0.03214053,
-0.03294926,
0.018352972,
-0.0341754,
0.0019973696,
-0.0057295975,
0.009150399,
0.005423062,
0.017622506,
0.010774382,
-0.028149052,
-0.002227271,
-0.040906128,
0.027157705,
0.0072394456,
-0.0049436935,
-0.0066459416,
0.0108983,
-0.015144138,
-0.030705685,
0.012228793,
0.0036164618,
-0.012841864,
-0.0072851,
0.018352972,
-0.003981695,
0.015783297,
-0.014074526,
0.013083179,
0.017765991,
0.030810038,
-0.0074155405,
-0.019513894,
0.03281882,
-0.02379234,
-0.009691726,
0.022892302,
0.023427106,
0.00073291233,
0.008967781,
-0.0014968043,
-0.019200835,
0.017192053,
-0.023674944,
-0.015013698,
0.022709684,
0.024183663,
0.033731904,
-0.022253143,
0.00049445085,
-0.0028908867,
-0.002398474,
0.0020593288,
-0.0013647333,
-0.018731251,
0.014335407,
0.0028974088,
0.04085395,
-0.0019354103,
-0.012170095,
-0.019748686,
-0.008296014,
-0.04648898,
0.007128571,
-0.017922519,
0.036027655,
0.005905692,
-0.0041219187,
-0.025109788,
0.0026658769,
-0.01579634,
-0.00783295,
0.005090439,
-0.00032467447,
0.015105005,
0.022122702,
-0.0063948436,
0.038453847,
-0.02407931,
0.020700902,
-0.02817514,
-0.007056829,
0.0068676905,
-0.010017827,
0.020818299,
0.02530545,
-0.005442628,
-0.02940128,
0.016226793,
0.022096615,
-0.016239837,
0.011498326,
-0.002943063,
0.018248621,
-0.013311449,
0.0028582767,
-0.018509502,
-0.004196922,
-0.0015285992,
-0.015809383,
-0.0033099267,
-0.0093460595,
-0.0116352895,
-0.00042148575,
-0.02775773,
-0.0075459806,
0.0055371975,
0.018887779,
-0.00067136076,
-0.02955781,
0.005980695,
-0.027862083,
-0.0052143573,
0.000983195,
0.011915736,
0.0051850085,
0.0142832305,
-0.0044806297,
-0.015352842,
-0.024170619,
0.0011413541,
0.00673725,
0.004526284,
-0.00673725,
-0.023101006,
-0.002695226,
-0.028514285,
-0.008980826,
0.008243837,
-0.0078003397,
-0.008009044,
-0.024431499,
0.016839864,
0.017948607,
-0.014778905,
-0.020779166,
-0.007604679,
-0.019044308,
-0.011791818,
-0.008909084,
0.0073894523,
-0.01998348,
-0.011804862,
-0.0035316756,
-0.029166488,
-0.0012139116,
-0.0037795124,
-0.04552372,
-0.032766644,
-0.001131571,
0.17666857,
-0.021379191,
-0.007969912,
0.002266403,
0.003929519,
-0.008472108,
0.022996653,
0.0077351197,
-0.02072699,
0.009072134,
0.0043664947,
-0.014844124,
-0.009528676,
0.004216488,
0.008948215,
-0.01689204,
-0.040280014,
-0.02040089,
-0.012691857,
-0.0066002873,
0.02940128,
-0.021718336,
-0.0044219317,
-0.011191792,
0.027705554,
-0.0023593418,
-0.015118049,
0.02488804,
0.026244622,
0.006150268,
-0.023140138,
0.025748948,
0.0069394326,
0.020322625,
-0.023270579,
0.010761338,
0.010383061,
-0.02462716,
0.0077416413,
0.0012139116,
-0.0065578944,
-0.01991826,
-0.0146354195,
-0.011113527,
-0.0014169095,
0.008106874,
-0.0052730558,
-0.01730945,
-0.0071742255,
-0.011211358,
-0.027470762,
-0.010506979,
-0.0062513594,
0.04004522,
-0.0052567506,
-0.0040110443,
0.048393413,
-0.00093183405,
-0.0049306494,
0.023074917,
0.017205097,
0.01286143,
-0.02002261,
0.031410065,
-0.011002653,
0.020896561,
-0.02344015,
-0.014674552,
-0.002714792,
-0.021274839,
0.004999131,
-0.035036307,
-0.0040436545,
-0.002520762,
-0.003717553,
0.008746033,
0.042445328,
0.006665508,
0.0013231555,
0.010343929,
-0.014544112,
0.021170488,
-0.010291752,
0.017557286,
-0.012274448,
-0.04925432,
0.028827343,
-0.0049110833,
-0.039575636,
-0.021105267,
0.0032756862,
0.0037860344,
-0.0083808,
-0.01914866,
0.0147658605,
-0.0071416153,
0.0024995655,
-0.0019435629,
-0.0011519523,
-0.031123094,
-0.012450542,
0.07904692,
-0.009072134,
0.012913606,
-0.039314754,
0.0049371715,
-0.011400497,
-0.012528806,
0.01228097,
-0.0021930302,
0.024692379,
-0.027522938,
-0.003262642,
-0.018339928,
-0.009202574,
0.0291404,
-0.0012269556,
-0.047767296,
-0.004461064,
0.0021962912,
-0.0034990655,
-0.0077677295,
0.006662247,
0.033549286,
-0.013350582,
0.020687858,
-0.0018913867,
0.0026984871,
0.021835733,
-0.044819344,
-0.010115658,
-0.017661639,
-0.0032822082,
0.02353146,
0.008719945,
-0.016435498,
-0.0010068374,
-0.0122353155,
-0.008759077,
0.008935172,
-0.004536067,
-0.019553026,
0.0019370408,
-0.010480891,
0.007122049,
-0.027653378,
0.004751294,
0.0055371975,
-0.022161834,
-0.00560894,
0.004134963,
-0.02563155,
-0.0077807736,
-0.0034729773,
0.016096354,
-0.015965912,
-0.009789557,
-0.034958042,
0.003681682,
0.014126702,
-0.014544112,
0.036810298,
0.03148833,
0.0077155535,
0.0012954369,
-0.0052045747,
-0.1634158,
0.019774774,
-0.00052216946,
-0.029114312,
0.0026903346,
0.005970912,
-0.0054980656,
-0.0018783427,
0.026309842,
0.009861299,
0.04004522,
-0.008185139,
-0.037801646,
0.011648334,
-0.003184378,
-0.008452542,
-0.031070918,
0.029427368,
0.013565809,
-0.0021897692,
0.005302405,
-0.018522546,
0.014139746,
-0.019422585,
-0.009385191,
0.026896823,
0.023466239,
0.0049371715,
-0.013696249,
-0.012633159,
-0.003916475,
0.019787818,
0.048889086,
-0.016526807,
0.011302666,
-0.007435106,
-0.02324449,
-0.00024437206,
0.012241838,
-0.003636028,
0.039288666,
0.015678944,
0.028227316,
0.0037305972,
-0.02269664,
0.03253185,
-0.0025794602,
-0.024679335,
0.033549286,
-0.007585113,
0.008452542,
0.004059959,
0.021640074,
0.009939563,
0.0072459676,
0.0094634555,
-0.009496066,
0.029062135,
-0.0050121746,
-0.0028061005,
-0.0082568815,
-0.034358017,
0.019409541,
-0.0129527375,
0.017739903,
-0.017622506,
-0.009633028,
0.018157313,
-0.0017870343,
0.0006803285,
-0.016865952,
-0.010246098,
0.015418063,
-0.0032968826,
0.011172226,
0.0037012482,
-0.0052632727,
0.024835864,
0.007050307,
-0.022096615,
-0.01743989,
-0.012104875,
-0.014752816,
-0.020413933,
-0.0052404455,
-0.0052600116,
-0.0077025094,
0.025931563,
-0.010526545,
-0.005664377,
0.022200966,
-0.020257404,
-0.00793078,
-0.0060100444,
-0.00013706439,
0.019813906,
-0.0001587705,
0.0049013,
0.022553155,
0.008550372,
-0.002230532,
-0.018235577,
-0.027235968,
0.0041806167,
0.015678944,
-0.020544372,
-0.02817514,
-0.0060067833,
0.018222533,
0.0008600918,
0.008146007,
0.01186356,
0.02153572,
0.021900954,
0.00680247,
0.01956607,
-0.023766253,
-0.010611332,
0.020883517,
-0.00847863,
0.038062528,
-0.007356842,
0.016239837,
0.0037208141,
-0.0082568815,
0.0016655617,
-0.12449238,
-0.017674683,
0.0052730558,
-0.014400627,
-0.014439759,
0.02604896,
-0.0046697687,
0.015131094,
-0.021992262,
0.030236099,
-0.033314493,
-0.0024702162,
-0.018639943,
-0.005305666,
0.011557025,
0.003655594,
-0.004526284,
-0.0029577375,
-0.027392497,
0.03610592,
-0.0035349366,
-0.01730945,
-0.0037240752,
-0.026062004,
-0.0006489413,
-0.010800471,
-0.024157574,
0.01934432,
0.013683205,
0.03326232,
-0.010506979,
-0.00018954629,
0.008139485,
0.0051784865,
-0.016044177,
-0.011889649,
-0.008804731,
-0.032923173,
0.04909779,
0.0134745,
0.009333015,
0.0084981965,
0.009469978,
-0.0043632337,
0.009965652,
0.00854385,
-0.01318753,
0.0021424845,
0.017661639,
-0.03542763,
-0.016122442,
-0.03477543,
-0.03772338,
0.0015628398,
0.0013598418,
-0.01318753,
-0.010448281,
0.0010092831,
0.0074872826,
-0.0123527115,
0.024588028,
0.010754816,
-0.018953,
0.009280839,
0.01943563,
-0.01914866,
-0.0052861,
-0.021287883,
0.004278447,
-0.026427237,
-0.011550503,
0.0034501501,
-0.019031264,
0.0028778426,
-0.008185139,
0.00999174,
-0.0247576,
-0.021105267,
0.013761469,
-0.047219448,
-0.0012188031,
-0.010578722,
0.025096744,
-0.014752816,
0.042210534,
0.011361364,
-0.00957433,
-0.0051817475,
0.0021294407,
-0.013748425,
-0.0068546464,
0.037097268,
0.019813906,
0.00786556,
-0.015900692,
0.020687858,
-0.0028680598,
-0.017805124,
0.015091961,
0.008074265,
-0.020766122,
0.013865821,
-0.05194139,
0.009183008,
-0.011009175,
0.0016296905,
0.007617723,
-0.02440541,
0.010363495,
-0.016396366,
0.0023593418,
0.031931825,
-0.007272056,
0.012554894,
-0.0065644165,
0.016226793,
-0.0117526855,
-0.023192314,
0.03036654,
0.0040664813,
0.030992653,
0.018874735,
0.012502719,
0.0020038916,
0.009965652,
0.024927173,
-0.0051654424,
0.010839603,
-0.01318753,
0.030001307,
0.0030506763,
-0.0065774606,
0.031436153,
-0.022240099,
-0.016318101,
0.0040893084,
-0.015678944,
-0.025618507,
-0.0074090185,
0.02749685,
0.041740946,
0.023557547,
0.009437367,
-0.02885343,
-0.024222793,
-0.00026760675,
-0.011857038,
-0.006424193,
-0.036445066,
0.03803644,
0.009319971,
-0.002408257,
0.024353234,
0.007845994,
0.0047121616,
-0.017361626,
-0.010970043,
0.010454803,
0.017661639,
-0.010180878,
0.00338493,
-0.010193923,
0.026975088,
0.005579591,
-0.0002484483,
-0.006495935,
-0.015144138,
-0.029323015,
-0.017413802,
0.00735032,
-0.0054621943,
-0.015300666,
-0.004588243,
0.021196576,
-0.0021750948,
0.017661639,
0.019174747,
0.0008690596,
0.0052404455,
0.003065351,
0.0068872566,
0.024705423,
0.00013400719,
0.0196052,
-0.016592028,
0.041245274,
0.03652333,
-0.007519893,
-0.0072198794,
0.003714292,
0.011172226,
0.0060263495,
-0.0068481243,
0.023427106,
0.0019142138,
0.024953261,
0.008680813,
0.021457456,
-0.013774513,
-0.01086569,
-0.0054524112,
0.01757033,
-0.0089743035,
-0.013383191,
-0.01798774,
-0.015535459,
-0.009587374,
0.009372147,
-0.019487806,
-0.037932087,
-0.013122311,
-0.0025973958,
0.029662162,
-0.0066198534,
-0.015196314,
-0.0009016697,
-0.024288014,
-0.018626899,
-0.019109529,
0.020009566,
-0.0045588943,
0.027783819,
-0.00796339,
0.02098787,
-0.010676552,
0.008765599,
0.005276317,
0.0037208141,
0.018822558,
-0.018509502,
0.018509502,
0.0068937787,
0.0167616,
0.0069133444,
-0.026362017,
-0.013487544,
-0.011041786,
-0.022292275,
0.010676552,
0.01969651,
-0.033731904,
0.08322102,
0.014687596,
-0.00007693949,
0.015274578,
-0.0051621813,
0.027053352,
0.0037045092,
0.0033229708,
0.0074807606,
-0.012124441,
0.002388691,
-0.030027395,
0.0022794472,
-0.049019527,
-0.023401018,
0.0113874525,
0.0004394213,
-0.020583505,
-0.0023348844,
-0.0291404,
0.008954737,
0.0012791317,
0.0116287675,
0.014961521,
-0.0077546854,
0.004001261,
0.014048438,
0.0028664293,
-0.005948085,
-0.028670814,
0.008289492,
-0.006525284,
-0.02775773,
-0.015105005,
0.011498326,
-0.017674683,
-0.007435106,
-0.00017497365,
0.033079702,
-0.011837472,
-0.0065513724,
0.019044308,
-0.024170619,
0.0091047445,
0.008491674,
-0.037462503,
-0.016905084,
-0.011485282,
-0.0072851
] |
Malignant cells often display defects in autophagy, an evolutionarily conserved pathway for degrading long-lived proteins and cytoplasmic organelles. However, as yet, there is no genetic evidence for a role of autophagy genes in tumor suppression. The beclin 1 autophagy gene is monoallelically deleted in 40-75% of cases of human sporadic breast, ovarian, and prostate cancer. Therefore, we used a targeted mutant mouse model to test the hypothesis that monoallelic deletion of beclin 1 promotes tumorigenesis. Here we show that heterozygous disruption | [
-0.038018163,
-0.008893914,
0.011887313,
-0.035522558,
-0.03655797,
0.03615973,
-0.03642522,
0.020960433,
-0.03865534,
0.0026449438,
0.018172788,
-0.0062356954,
0.026402976,
0.019460414,
-0.01177448,
-0.002880566,
0.036982752,
0.008137267,
-0.0045896578,
0.014323183,
-0.025287919,
0.040726162,
0.00028975742,
-0.033265892,
0.008893914,
0.011927137,
0.013539989,
-0.04024828,
-0.006796543,
-0.0011391179,
0.017655082,
-0.004490099,
-0.00020648068,
-0.005834142,
0.0077456697,
-0.013400606,
0.030265857,
-0.011747931,
0.030080013,
-0.003995624,
0.0027776887,
0.037726123,
-0.024557821,
0.005578608,
0.0042976188,
0.0023363116,
-0.013214763,
-0.0035310166,
-0.0011084207,
-0.014044419,
-0.004616207,
0.0069492,
-0.024358705,
0.013586449,
-0.03618628,
0.00854214,
0.0020542287,
0.024677292,
0.004765545,
-0.001426179,
0.00965056,
-0.017933847,
-0.030823385,
0.00070852635,
-0.00059030036,
0.0156240845,
0.002391069,
0.0015522867,
-0.0044701872,
-0.00330535,
0.044655412,
0.014774516,
-0.01032756,
0.0006749253,
0.0028506985,
-0.031141972,
-0.02038963,
0.0178542,
-0.027146349,
0.006657161,
0.020163963,
-0.019925022,
0.017416142,
0.025367565,
0.027013604,
0.0065244157,
-0.011535539,
0.01143598,
0.015398418,
0.010088619,
0.024584372,
0.0038296927,
0.03387652,
0.008907189,
-0.019526787,
0.015265673,
0.002459101,
0.034566794,
-0.005173736,
-0.025194997,
-0.0070487587,
0.010234638,
-0.00984304,
-0.0030796835,
-0.036372125,
-0.000283535,
0.009829766,
-0.004649393,
0.012750155,
-0.007725758,
-0.017668357,
0.008528865,
-0.0066339304,
-0.02523482,
0.03069064,
-0.0044170893,
0.007247876,
0.01573028,
-0.015278948,
0.0065542837,
0.028885309,
0.020044493,
0.032734912,
-0.027425114,
0.01867722,
0.006497867,
-0.02092061,
-0.004772182,
-0.010944824,
-0.008781081,
0.019460414,
0.025248095,
0.0034546882,
0.00046792606,
-0.008913825,
0.0024939463,
-0.02000467,
-0.0156240845,
-0.018239161,
-0.027318917,
0.0074735424,
0.03838985,
-0.012511214,
0.004586339,
-0.020097591,
0.008090807,
0.0036106636,
0.005080814,
-0.011635098,
0.008708071,
-0.009663835,
-0.005552059,
0.009079757,
-0.030876484,
0.017933847,
0.015517889,
-0.0021438315,
0.002900478,
-0.028646367,
-0.025314469,
-0.004639437,
0.0014577059,
0.026947232,
0.011004559,
0.022340981,
0.027451662,
0.010871814,
-0.0005961079,
-0.019433865,
-0.015026732,
0.015292222,
0.0370624,
-0.021371942,
0.011728019,
-0.024889683,
0.004224609,
-0.0007060374,
0.015955947,
-0.03754028,
-0.0069425628,
-0.013387332,
0.031115424,
0.015690457,
0.00209903,
0.01063951,
0.014721419,
0.020880787,
-0.015902849,
0.01336742,
-0.025712702,
-0.0076593854,
0.00025283772,
0.003686992,
-0.010805442,
-0.6278307,
-0.031062325,
0.015132928,
0.0037234968,
-0.0007110153,
0.04308902,
0.032150835,
-0.024650743,
-0.012166077,
-0.0026200542,
-0.01257095,
0.027425114,
0.015703732,
-0.016141789,
-0.019579886,
-0.025725977,
-0.007081945,
-0.03015966,
0.031619854,
-0.0013747403,
-0.017376319,
0.0021438315,
-0.01310193,
0.009491267,
-0.0014676617,
0.028991504,
0.027849898,
-0.0076129246,
0.0039126584,
0.043779295,
-0.024358705,
0.021531235,
-0.033823423,
-0.012365195,
0.046965174,
0.0063949893,
-0.006497867,
0.016486926,
0.013539989,
0.034593344,
-0.0010154991,
0.011482441,
0.028858759,
-0.015265673,
-0.018053317,
0.008867365,
-0.00087196863,
-0.0005849076,
-0.0031908576,
-0.024040116,
0.02605784,
0.034035813,
-0.026004743,
-0.015332046,
0.010699245,
0.008980198,
0.049593527,
-0.03544291,
0.023761353,
0.004967981,
0.001259418,
0.018000219,
-0.0028822254,
-0.015597535,
-0.0034779184,
-0.008017797,
-0.0076062875,
-0.0016145109,
-0.007380621,
0.014495752,
0.022951607,
0.026575545,
-0.021451589,
0.0027760295,
0.027849898,
0.05296525,
-0.0068164547,
-0.006896102,
-0.0025055616,
0.0021753584,
0.010705883,
-0.0014212009,
-0.021610884,
0.010500128,
0.024186136,
0.0027428432,
-0.009471354,
0.04075271,
-0.01416389,
0.011655009,
0.0277968,
-0.0008022775,
0.00033974418,
-0.033504833,
-0.016805515,
0.015889574,
-0.007626199,
-0.0014021188,
0.00041026497,
-0.0357084,
-0.026456075,
-0.006673754,
0.004712447,
0.0077390326,
0.010500128,
0.008688159,
-0.023469312,
-0.019606434,
0.023734802,
-0.016991358,
0.007851866,
-0.008581963,
0.0038396486,
0.006989023,
-0.026097663,
-0.017243573,
-0.007300974,
0.02065512,
0.0020807777,
-0.014774516,
0.0071615917,
0.009597463,
0.00972357,
-0.012511214,
0.017190475,
0.0076925717,
0.009803217,
-0.019075453,
-0.0030730464,
-0.0036272567,
-0.0071084937,
-0.023150725,
0.013978046,
-0.022885235,
0.022646295,
0.0015240783,
0.01317494,
-0.0007412978,
0.016885161,
-0.0092656,
-0.030239306,
-0.0070222095,
0.006700303,
0.0017970352,
-0.014601948,
0.003988987,
-0.012770067,
-0.006504504,
0.011017834,
0.017349768,
0.01829226,
0.0071217683,
-0.017522337,
0.0068297293,
0.018371906,
-0.0047489516,
-0.028248133,
-0.023973744,
-0.010354109,
-0.018637396,
0.011177127,
0.011734656,
-0.0033932936,
0.012219176,
0.0014859141,
-0.0019131871,
0.020615296,
0.010314285,
-0.0067567197,
-0.018610846,
-0.007851866,
-0.015690457,
-0.007281062,
0.020084316,
0.0043872218,
0.0038993838,
-0.022646295,
-0.008004523,
-0.0061294995,
-0.00417483,
0.015743556,
-0.030770287,
0.0019098684,
-0.00267813,
0.030451698,
0.027292369,
0.016752416,
-0.0046991725,
0.0077456697,
0.032628715,
-0.023004705,
0.019407317,
-0.011343059,
0.013062106,
-0.0068828273,
-0.020787865,
0.012119617,
0.022340981,
0.011469167,
0.031566758,
0.0017903979,
-0.012643959,
0.009006747,
-0.02260647,
0.015517889,
-0.0081903655,
0.0014494093,
-0.007639474,
-0.010878451,
0.0006720215,
-0.0018186063,
0.0142302625,
-0.0080111595,
0.01105102,
0.00041918378,
0.006205828,
0.016991358,
-0.00854214,
0.0051305937,
-0.015278948,
0.010964735,
0.007573101,
-0.011376245,
-0.022792313,
0.011429343,
0.0032489335,
0.013194852,
0.026336605,
0.0010395591,
-0.013991321,
-0.00021094008,
0.032442875,
0.00092423696,
0.0137656545,
0.0017339813,
0.017548887,
0.011276687,
0.0056084753,
0.037434086,
-0.013593086,
-0.031035777,
0.008761168,
-0.009365158,
0.011874039,
0.003346833,
0.0027942818,
0.02907115,
0.00798461,
-0.02053565,
-0.00095991214,
-0.014721419,
0.011475803,
-0.006567558,
-0.0049016085,
0.001599577,
-0.02620386,
0.001551457,
0.0064248573,
0.04683243,
0.017907297,
0.02523482,
0.00010899608,
-0.015889574,
-0.006222421,
-0.008814267,
-0.008097444,
0.013274498,
0.012803254,
0.004420408,
-0.027013604,
-0.037407536,
-0.012816528,
0.02236753,
-0.037142046,
0.017907297,
0.022619745,
0.0077124834,
0.030717188,
0.0158763,
0.011323147,
-0.022566646,
-0.040832356,
0.038044713,
0.031327818,
-0.016991358,
-0.008907189,
-0.02936319,
0.0020376355,
0.015146202,
0.0072080526,
-0.00015618277,
0.020456001,
0.00038827906,
0.02523482,
-0.009491267,
-0.0075266403,
0.009252326,
-0.025991468,
0.021292295,
-0.014429379,
-0.00972357,
-0.008163816,
-0.030557895,
0.017150652,
0.01546479,
0.013327597,
-0.009750119,
-0.00068197737,
-0.011064295,
-0.03231013,
-0.01596922,
-0.011674921,
0.017933847,
-0.008781081,
-0.020960433,
-0.0142302625,
0.002980125,
0.00972357,
0.019287845,
0.034965027,
-0.02089406,
-0.020854237,
0.00090100657,
0.010486853,
0.01269042,
0.042000514,
0.0010121805,
0.017840926,
-0.0012386766,
0.022394078,
-0.017363044,
-0.008635061,
0.03286766,
-0.0171772,
-0.023801176,
-0.0074469936,
-0.014522301,
-0.005266657,
0.036133185,
0.020217061,
-0.005021079,
-0.029416287,
0.00006766883,
-0.014070968,
-0.00320911,
-0.009643923,
0.014336458,
0.020801138,
0.01918165,
0.0038794721,
0.025221547,
0.012185989,
0.012796616,
-0.003617301,
-0.0026731521,
0.018013494,
0.011110755,
0.017694905,
0.011369607,
-0.03594734,
0.011568725,
0.033743776,
-0.0008167965,
0.02024361,
0.030664092,
0.009564276,
-0.0008209447,
-0.001997812,
-0.0022019073,
-0.007977974,
0.0053396667,
0.021133002,
-0.009099669,
-0.029681778,
0.011582,
-0.014933811,
-0.0032373182,
-0.018332083,
0.01797367,
0.008960286,
-0.027823348,
0.0045830207,
0.0009043252,
0.006381715,
0.01261741,
-0.038150907,
-0.0019131871,
0.0064580436,
0.012199264,
-0.02287196,
-0.0023363116,
-0.016380731,
-0.028540172,
-0.014389556,
0.006902739,
-0.026124213,
-0.018199338,
-0.006398308,
-0.0058739656,
0.029681778,
0.0067567197,
-0.01744269,
0.009086394,
0.05373517,
-0.0040354473,
-0.027026879,
-0.0013365761,
-0.03594734,
0.018783415,
0.012398382,
0.0013797182,
-0.028911857,
-0.031088876,
-0.0002451634,
0.008157179,
-0.009378433,
0.019898472,
0.010666059,
-0.0065907883,
0.0017373,
0.0059171077,
0.029044602,
0.011601912,
0.0001492344,
0.015863026,
-0.008674884,
-0.026668467,
-0.028805662,
-0.027823348,
-0.027066702,
-0.0022301157,
0.001317494,
0.003949163,
-0.010473579,
-0.012478028,
0.012730244,
-0.014628497,
-0.0014950404,
0.0016750757,
0.028354328,
-0.0089403745,
0.013938223,
0.000998906,
-0.0056317057,
-0.025447214,
-0.016858613,
0.022659568,
0.0118474895,
-0.014389556,
0.006753401,
-0.02608439,
-0.010898363,
-0.020363081,
0.011694833,
-0.023031255,
0.017270122,
0.012743519,
-0.02907115,
-0.020031217,
-0.0023479268,
-0.009776668,
0.01177448,
0.0031228256,
-0.030318955,
-0.0071151312,
0.010652785,
0.0037965064,
-0.016062142,
0.0065642395,
-0.033159696,
-0.012862989,
0.02287196,
-0.004420408,
0.007035484,
-0.009604099,
0.002487309,
-0.022579921,
-0.014681595,
-0.009982423,
-0.02487641,
-0.0015945991,
-0.011535539,
0.053230736,
0.022340981,
0.027610956,
0.00014830104,
0.028752564,
0.019340944,
0.014747968,
-0.013805478,
-0.017044457,
0.023588784,
-0.005153824,
0.03461989,
0.0016916689,
0.0151594775,
0.026602095,
-0.00019548772,
0.013978046,
0.016845338,
-0.009086394,
-0.020402905,
0.0044170893,
-0.03438095,
-0.03650487,
0.024916233,
-0.018637396,
-0.0031593307,
-0.039027024,
0.012889538,
0.005711353,
0.019858649,
0.0011275026,
-0.0037434085,
0.015358594,
-0.02596492,
0.023203824,
-0.02062857,
-0.012026696,
-0.00226828,
-0.030345503,
0.012000146,
-0.017509064,
-0.00096074183,
-0.001896594,
0.006252289,
0.010619598,
-0.043248314,
0.009232414,
-0.0010130102,
-0.020641845,
-0.014947085,
-0.026004743,
-0.031088876,
-0.015172752,
-0.028858759,
-0.017416142,
-0.014402831,
-0.0042378837,
0.021438316,
-0.026867585,
0.022407353,
0.021517962,
-0.03597389,
0.018982533,
0.0012295505,
0.009358522,
0.0064314944,
0.020973707,
0.023416216,
-0.01744269,
-0.018969258,
0.0009350225,
-0.0023728167,
0.0067235334,
0.012736881,
0.028858759,
-0.023376392,
0.0011971939,
0.019261297,
-0.01428336,
-0.01877014,
-0.03209774,
0.03910667,
-0.0058474164,
0.021849824,
-0.014376282,
-0.019672807,
-0.011475803,
0.0023993657,
-0.0155046135,
0.017309945,
-0.0029469386,
-0.008104081,
-0.011289961,
0.0011009537,
-0.0028241496,
0.0016037254,
0.016858613,
-0.026124213,
0.00092423696,
-0.014442654,
-0.00090017694,
0.024703842,
-0.021133002,
0.033956166,
0.0034281393,
0.010055432,
0.009185953,
0.0067036217,
0.0037765948,
-0.013951498,
-0.021796726,
0.040062435,
-0.026867585,
0.0030332229,
-0.02354896,
0.00057744066,
0.0037600016,
-0.007825317,
-0.0056947595,
-0.0032705045,
-0.021902923,
-0.014973634,
0.036743812,
0.027610956,
0.002210204,
0.0019015719,
-0.022792313,
-0.005797637,
-0.020867512,
-0.044336826,
0.02475694,
-0.040566865,
0.01746924,
-0.0071018566,
0.019433865,
0.024332155,
0.014323183,
-0.001184749,
-0.015225849,
0.047496155,
-0.0041084574,
0.0072279642,
0.001290945,
-0.010566501,
-0.02000467,
0.01746924,
-0.013082018,
-0.016924985,
0.0009665494,
-0.0025702748,
-0.016340908,
-0.016845338,
-0.01377893,
0.022287883,
0.020084316,
-0.016500201,
0.018186063,
0.0007670171,
0.022579921,
0.008562052,
-0.021478139,
0.0018949347,
-0.016898436,
0.0048949714,
0.009975785,
0.014721419,
-0.0316995,
-0.005100726,
-0.027425114,
-0.011223588,
0.0027776887,
-0.0076062875,
-0.01230546,
-0.020960433,
0.018743591,
0.015385143,
-0.0050940886,
-0.007924875,
-0.008966924,
0.007513366,
0.011163853,
0.004775501,
-0.007513366,
0.012630685,
-0.011110755,
0.012225813,
-0.012637323,
-0.0068164547,
0.005276613,
-0.022274608,
-0.012000146,
-0.00123038,
-0.038257103,
0.03889428,
0.017137377,
-0.0054292697,
0.0011366289,
0.00393257,
-0.015902849,
-0.025805624,
0.004765545,
0.014376282,
-0.012278911,
0.024956057,
-0.012544401,
-0.0037367712,
-0.0080708945,
0.019433865,
0.003969075,
-0.014880712,
-0.0024491448,
-0.002067503,
-0.010566501,
-0.00070852635,
-0.015066556,
-0.030823385,
0.0158763,
-0.010068707,
-0.033982717,
0.025394116,
-0.009079757,
0.010420481,
-0.022858687,
0.001628615,
0.010480217,
0.017031182,
0.0277437,
-0.01071252,
-0.0008068406,
0.0072279642,
0.018013494,
-0.0028025785,
-0.004138325,
-0.004738996,
0.0077456697,
-0.000010740158,
-0.037938517,
-0.017641809,
-0.005469093,
0.004393859,
0.016208163,
0.0555936,
0.0067633567,
0.02038963,
0.001548968,
-0.008528865,
-0.018225886,
-0.003766639,
-0.0080708945,
0.003730134,
-0.002391069,
0.0109780105,
-0.012577587,
0.008581963,
0.0018766822,
-0.02461092,
-0.013686008,
-0.015703732,
0.003225703,
-0.040726162,
0.010619598,
-0.01534532,
-0.014442654,
-0.0023047847,
0.011283323,
-0.0075465525,
-0.019513512,
0.00092008867,
0.0058308234,
-0.018252434,
0.00834966,
-0.008800993,
-0.0026366473,
-0.0112634115,
0.007274425,
-0.029575583,
-0.023084352,
0.020110864,
0.190728,
-0.04208016,
-0.016460378,
0.010393932,
-0.014655046,
-0.012020058,
0.012132891,
-0.013267861,
-0.008601875,
0.00267813,
0.0141107915,
-0.00020212498,
-0.008721345,
0.0006765846,
0.016447103,
-0.008628424,
-0.019725904,
-0.015225849,
-0.033664126,
-0.009039933,
0.00402881,
-0.028779112,
0.017336495,
-0.002065844,
0.042956278,
0.0050609023,
-0.032150835,
0.0098695895,
0.01083199,
0.0009682087,
-0.040460672,
-0.010281099,
0.011150579,
-0.026548997,
-0.002231775,
0.015199301,
-0.023270195,
-0.0017422779,
0.010500128,
0.0040254914,
-0.001599577,
0.019022357,
0.011615186,
-0.0059834803,
-0.023031255,
0.024093214,
0.000733416,
-0.02236753,
0.014787791,
-0.015570986,
-0.04709792,
0.021796726,
0.018425003,
0.022009118,
-0.0034082273,
-0.001660142,
0.026270231,
-0.004490099,
0.014681595,
0.037911966,
-0.003640531,
0.001368103,
-0.042478394,
0.021106452,
-0.00078236574,
0.008336385,
-0.014973634,
-0.0085355025,
0.036106635,
-0.039584555,
0.006046534,
-0.024664018,
-0.015982496,
0.008648336,
0.019194925,
-0.014827615,
0.009006747,
0.0122523615,
0.0028407427,
0.015371869,
-0.0019131871,
0.013267861,
-0.031115424,
-0.004904927,
-0.006073083,
-0.036345575,
0.014402831,
0.012245725,
-0.005754495,
-0.03411546,
0.001083531,
-0.020190513,
0.008004523,
0.0010992944,
0.01720375,
0.013586449,
0.014522301,
0.014681595,
-0.0065609207,
-0.046991725,
-0.02499588,
0.060425516,
-0.004782138,
0.0070553957,
-0.01466832,
0.0043573542,
-0.0013705919,
-0.00374009,
0.008867365,
-0.0069624744,
0.021093179,
-0.04285008,
-0.0032024728,
0.0033086687,
0.00071474875,
0.020110864,
0.010666059,
-0.013586449,
0.0462749,
-0.02251355,
-0.008296561,
-0.026110938,
0.01956661,
0.019314395,
0.005522191,
0.015478065,
-0.04574392,
0.011329784,
-0.0123120975,
-0.018478101,
-0.0037069037,
0.0040055797,
-0.023084352,
0.018438278,
0.011522264,
-0.0063352543,
-0.002917071,
-0.019354219,
-0.027690602,
0.009079757,
-0.023323294,
0.0066505237,
0.001684202,
0.009093031,
-0.009424894,
-0.0015282267,
0.018876337,
-0.0068164547,
-0.016911712,
-0.02263302,
-0.011960323,
-0.021438316,
-0.04521294,
-0.010247912,
0.011117392,
-0.026801212,
-0.002688086,
-0.032442875,
0.0042677512,
-0.004828599,
-0.019792277,
0.01317494,
0.031062325,
-0.0026764707,
0.0004521626,
-0.023628607,
-0.16630292,
-0.0020011307,
0.005857372,
-0.024212684,
0.009643923,
0.0075266403,
-0.00075291295,
-0.013247949,
-0.01744269,
-0.004191423,
0.020495825,
-0.008522228,
-0.03308005,
-0.021624157,
0.008090807,
-0.0026316692,
-0.0102744615,
0.03658452,
-0.008502316,
-0.0011781118,
0.027849898,
-0.03260217,
0.017774554,
-0.0076328367,
-0.027823348,
0.015478065,
0.02287196,
-0.007878414,
-0.0131218415,
-0.009969148,
-0.012531126,
0.0070686704,
0.010181541,
-0.0006214125,
0.01150899,
-0.000014959737,
-0.008920463,
-0.008429307,
-0.007234602,
0.020814413,
0.03865534,
0.044894353,
0.009564276,
-0.0067036217,
-0.017933847,
0.04181467,
0.0076062875,
-0.008820904,
0.014402831,
-0.010573138,
0.020787865,
0.005867328,
0.021225922,
0.014986909,
0.012743519,
0.015172752,
0.028141936,
0.016261261,
-0.010752344,
-0.0024474857,
-0.012657234,
-0.020217061,
0.016725868,
0.008090807,
0.00021799216,
-0.02065512,
-0.016420554,
0.00035550765,
-0.009126217,
0.002231775,
-0.014787791,
-0.0011905566,
0.03363758,
-0.016725868,
0.0138851255,
0.0064845923,
-0.002135535,
0.026562272,
0.009112943,
-0.0030398602,
-0.0073474348,
0.0075797387,
-0.024637468,
-0.013281136,
0.007858503,
0.0052998434,
0.00037728614,
0.0063186614,
-0.008197003,
-0.015451516,
0.005412677,
-0.007626199,
-0.0021637431,
-0.0077058463,
0.012391744,
0.03384997,
-0.01387185,
-0.01944714,
-0.010174903,
-0.0046560303,
0.010539952,
-0.019367494,
-0.011475803,
0.015584261,
0.047496155,
-0.009551002,
-0.009305423,
0.009013385,
0.04393859,
-0.01944714,
0.0048053684,
-0.00043847327,
0.0052533825,
0.0257658,
-0.017867474,
-0.00010184029,
-0.008880639,
-0.0030249264,
-0.0071084937,
-0.021464864,
0.07364692,
-0.000013391169,
-0.00019154686,
0.019340944,
-0.0098695895,
-0.021995844,
-0.12881573,
-0.025566684,
0.0074071703,
0.022141863,
-0.03592079,
0.0072080526,
-0.006116225,
0.0317526,
-0.015000183,
0.038549144,
-0.0076593854,
-0.013606361,
-0.01143598,
-0.015066556,
0.0034613253,
-0.023562234,
0.0277968,
0.004244521,
-0.014177164,
0.03284111,
-0.0029154117,
0.0198852,
0.003517742,
-0.005047628,
0.003720178,
-0.0061660046,
-0.0476289,
0.039823495,
0.005070858,
-0.007778856,
0.0008495679,
-0.014309909,
0.016964808,
0.005701397,
-0.008137267,
-0.023575509,
-0.008402757,
-0.03201809,
0.014416105,
-0.002465738,
-0.018478101,
0.018305533,
0.008641698,
0.0036836732,
0.005913789,
-0.0331066,
-0.004914883,
0.0058474164,
0.01466832,
-0.027159624,
-0.019964846,
-0.013115204,
-0.034513697,
-0.011090843,
-0.0014203714,
-0.02062857,
0.010991285,
0.026363153,
0.010586413,
0.0069160135,
-0.01269042,
0.0037467272,
0.005505598,
0.007135043,
0.024398528,
-0.028991504,
-0.01546479,
-0.047682,
0.025009155,
-0.02104008,
0.0057511763,
0.0069093765,
0.0029452792,
-0.022314431,
-0.014641772,
0.0055022794,
-0.011555451,
-0.00070562254,
0.0072080526,
-0.033292443,
-0.01584975,
-0.018491376,
0.033053502,
-0.022792313,
0.026137488,
-0.015225849,
0.012345283,
-0.008515591,
-0.006902739,
-0.017867474,
0.00036421904,
0.040062435,
0.005956931,
-0.025221547,
-0.039080124,
0.011794392,
0.020349806,
-0.0030630904,
0.0146948695,
0.030133111,
-0.0074934545,
-0.013188214,
-0.049328037,
0.014893987,
-0.007294337,
0.020230336,
-0.0030464972,
0.011973597,
0.012245725,
-0.013228037,
-0.012345283,
0.042133257,
-0.008880639,
0.0144559285,
0.00482528,
-0.014376282,
-0.01507983,
-0.028752564,
0.025712702,
-0.013805478,
0.016991358,
0.0528856,
-0.003119507,
0.0015307156,
0.014309909,
0.012093068,
-0.009006747,
-0.027929544,
-0.0038064623,
0.025102077,
0.0017240255,
-0.009239051,
0.014535575,
-0.028513622,
-0.017124103,
-0.0013979706,
-0.0045000548,
-0.032761462,
-0.00183354,
0.011223588,
0.015743556,
0.04943423,
0.014601948,
-0.020309983,
0.018066593,
-0.0047489516,
-0.010938186,
0.0024225959,
-0.026748113,
-0.002980125,
0.002907115,
0.0013722513,
0.032947306,
0.013573174,
-0.0011150579,
-0.015570986,
-0.0087147085,
-0.005565333,
-0.02012414,
-0.004244521,
-0.027318917,
-0.012630685,
0.0056848037,
0.013042195,
0.007679297,
0.021093179,
0.00034721108,
0.004324168,
-0.035761498,
-0.001440283,
-0.002912093,
-0.023535686,
-0.013712557,
0.010068707,
0.02289851,
-0.0127169695,
0.017097553,
0.0032373182,
-0.025619783,
0.000813063,
-0.0030564533,
0.024571097,
0.00069815567,
-0.009683747,
-0.011940411,
-0.00085371616,
0.013573174,
0.000866161,
0.0026001423,
0.008090807,
0.025314469,
-0.0034281393,
-0.012285548,
0.033425186,
0.012770067,
0.021756902,
0.008834179,
0.023535686,
-0.0036206194,
0.0024790126,
-0.012451479,
0.024186136,
-0.0037865506,
-0.0052401084,
-0.0042146533,
-0.0060963132,
-0.021491412,
0.025805624,
-0.039319064,
-0.03390307,
-0.026641918,
-0.01052004,
0.01257095,
0.012351921,
-0.0021322162,
0.007991248,
0.0042544766,
0.027849898,
0.009451442,
-0.0065741953,
-0.006733489,
0.024265783,
0.026256958,
0.019102003,
0.015186026,
0.007533278,
0.013659459,
0.007845229,
0.03281456,
-0.03249597,
0.011655009,
-0.028911857,
0.028248133,
-0.014070968,
-0.045584626,
-0.008515591,
-0.011568725,
-0.015637359,
0.020681668,
0.005791,
-0.0070686704,
0.07959389,
0.006889465,
-0.008575326,
0.0009765053,
-0.00965056,
0.024664018,
0.02352241,
0.024902958,
-0.011601912,
-0.013792204,
0.014867438,
-0.023509137,
0.027345467,
-0.023429489,
-0.014575399,
0.01782765,
-0.0136461845,
-0.007440356,
0.00919259,
-0.022115314,
0.018119691,
-0.012643959,
-0.0007417126,
0.036133185,
-0.031274717,
0.0041117757,
0.033026952,
0.026960505,
0.012166077,
-0.023124175,
0.014296635,
-0.019779002,
-0.033690676,
-0.012995734,
0.029018054,
-0.017296672,
0.0033070093,
-0.03209774,
0.0069691115,
0.0032539114,
-0.008681522,
0.009803217,
-0.005807593,
-0.019553335,
0.011004559,
-0.02499588,
-0.004931476,
-0.004967981,
0.0067600384
] |
CONTEXT Fatal adverse events (FAEs) have been reported in cancer patients treated with the widely used angiogenesis inhibitor bevacizumab in combination with chemotherapy. Currently, the role of bevacizumab in treatment-related mortality is not clear. OBJECTIVE To perform a systematic review and meta-analysis of published randomized controlled trials (RCTs) to determine the overall risk of FAEs associated with bevacizumab. DATA SOURCES PubMed, EMBASE, and Web of Science databases as well as abstracts presented at American Society of Clinical Oncology conferences from January 1966 to October 2010 were searched to identify | [
-0.016532678,
-0.03611673,
0.00539252,
-0.036721747,
-0.022135638,
0.0071812584,
-0.04753309,
0.010101111,
-0.017729554,
0.013599672,
0.008305796,
0.0024644474,
0.015059599,
0.023016853,
-0.0070168525,
0.0008639541,
0.04308755,
-0.00021167286,
-0.003639951,
-0.0028244967,
-0.012961777,
0.018939583,
-0.018558161,
-0.0033555285,
-0.018150434,
0.016993014,
0.009239622,
-0.046033707,
-0.0028508017,
-0.018531855,
0.023832308,
-0.0007731197,
-0.010482533,
-0.010245788,
-0.0028771067,
0.021070287,
0.0037780523,
0.0050308267,
0.010824498,
-0.0019580766,
0.0232536,
0.008489931,
0.008364982,
0.011804358,
-0.021859435,
-0.013310318,
0.014783396,
-0.021530623,
-0.016887795,
0.029724622,
0.023819156,
-0.0031878343,
-0.010916565,
0.00027414717,
-0.00980518,
-0.0054286895,
-0.02610769,
0.014954379,
0.00026017264,
-0.019255243,
-0.007898069,
0.009824908,
-0.010272093,
0.007759968,
-0.018689685,
0.0013423758,
0.00014539664,
0.015572546,
0.00040526103,
-0.011074395,
0.032591864,
0.03256556,
-0.0060501443,
-0.004182491,
0.017611181,
-0.009081793,
-0.031224007,
-0.0038471026,
-0.0058824504,
0.013915332,
0.0077533918,
0.0041397456,
0.011692562,
0.031855326,
0.01659844,
0.006332923,
-0.013757503,
0.020807236,
-0.0076415953,
-0.005211673,
0.015730375,
0.0008524456,
-0.014428279,
0.019873409,
-0.0069708186,
0.01955775,
0.007740239,
0.022517059,
0.02489766,
-0.025713114,
0.009851214,
0.0029198523,
-0.043166466,
-0.008463626,
-0.022451296,
-0.0047940817,
-0.006444719,
0.017637486,
0.009265928,
-0.000242499,
-0.022530211,
0.040535968,
-0.001212495,
0.0048039462,
-0.009101522,
-0.0030365807,
0.031145092,
0.008555694,
-0.011659681,
-0.013461571,
0.0014311551,
0.004603371,
0.024253188,
-0.02342458,
0.029066999,
-0.019386766,
-0.01363913,
-0.01786108,
0.0011968764,
-0.0071746823,
0.030013978,
0.019755038,
0.03161858,
-0.01559885,
-0.025279082,
0.0052412665,
-0.06639376,
-0.019689275,
-0.009075217,
-0.03424908,
0.0029971232,
0.0022211263,
-0.01612495,
-0.008364982,
-0.04513934,
0.017953146,
0.029461574,
0.018597618,
0.009029183,
-0.0028655983,
0.0016300865,
-0.04098315,
0.0028655983,
-0.0048993016,
-0.008095357,
-0.013237979,
-0.00007793877,
0.014572957,
-0.01701932,
-0.02675216,
-0.0004533498,
0.015664613,
0.010166873,
0.001992602,
0.012073984,
0.023148378,
-0.0027061244,
-0.03530128,
-0.005155775,
-0.031118786,
-0.01565146,
0.041298814,
-0.011600494,
0.008483355,
-0.0072404444,
-0.0004496507,
-0.008937116,
0.017690096,
-0.017742706,
-0.013303742,
0.0026715992,
0.008325525,
0.033591453,
-0.006471024,
-0.014704482,
0.011587342,
0.02120181,
-0.013362927,
0.006497329,
-0.03267078,
0.0012182492,
0.014967531,
-0.005714756,
-0.033854503,
-0.625848,
-0.013343199,
0.010515414,
-0.0053267577,
0.026028773,
0.0059416364,
0.017519115,
-0.0020846694,
0.006905056,
0.014388822,
-0.01078504,
0.029172217,
0.017900536,
-0.01234361,
0.0015396632,
-0.002398685,
-0.013231403,
-0.03240773,
0.019952325,
-0.0028162764,
-0.014625567,
0.032802306,
-0.00420222,
0.010469381,
0.0023838885,
0.018110976,
0.034801483,
-0.01807152,
0.006313194,
0.028304154,
-0.03303905,
0.013757503,
0.014415127,
0.004261406,
0.04890095,
0.0052873003,
0.010390465,
-0.00075092487,
-0.02500288,
0.022845872,
-0.0066255657,
0.00049897254,
0.04624415,
0.00065104815,
-0.029724622,
0.029251134,
0.02256967,
0.010429923,
-0.0026091249,
0.0014229348,
0.015927663,
0.024700372,
-0.031671192,
0.008174271,
0.0014467736,
0.014046857,
0.022122486,
-0.009213318,
-0.012692151,
0.013251131,
0.00062926434,
-0.0065861084,
-0.030671602,
-0.026291823,
0.00307275,
0.031802718,
0.00787834,
0.031750105,
0.011751748,
0.0016333746,
0.031644884,
0.011034938,
0.009029183,
0.008700371,
0.060711883,
0.005175504,
0.019676123,
0.035906292,
-0.033722978,
0.0024397864,
0.011843815,
-0.0040049325,
-0.026133994,
0.022477603,
0.01971558,
0.013356351,
-0.021004524,
0.007740239,
0.021346487,
-0.0057246205,
0.0047053024,
0.010778463,
-0.037931774,
-0.039667904,
0.0016835184,
0.0073193596,
0.01623017,
0.015217429,
0.007911221,
-0.032749694,
-0.027620224,
-0.013494452,
0.011567613,
-0.025489522,
-0.009943281,
0.020741474,
-0.026936295,
-0.016940404,
0.035564326,
-0.015769834,
-0.010443076,
0.004580354,
0.007819154,
-0.014099468,
-0.00006987259,
-0.025831487,
-0.013599672,
-0.0063986853,
-0.004212084,
-0.03177641,
0.029093303,
0.0023082616,
0.006707769,
0.011955611,
0.02045212,
0.005126182,
-0.018268805,
-0.026870534,
-0.017308675,
-0.019360462,
0.025752572,
-0.009147556,
0.020346899,
-0.0017986028,
0.013678588,
-0.022451296,
0.0044060834,
-0.00011087136,
-0.028646119,
-0.014941227,
-0.020609949,
0.018255653,
0.010252364,
0.010443076,
-0.019899715,
0.0041594743,
-0.0014632143,
0.021004524,
-0.0033456641,
0.030724213,
0.0020386355,
0.0003286067,
0.0031976986,
0.009811756,
0.030382248,
-0.008969997,
-0.008963421,
-0.025594741,
0.0020863134,
-0.01759803,
0.012258119,
-0.01271188,
-0.018110976,
-0.015072751,
-0.0073785456,
-0.037931774,
-0.010528566,
-0.0009420469,
-0.0045474726,
-0.026383892,
-0.0015396632,
-0.03827374,
0.0026584466,
0.035485413,
-0.0032651052,
0.029093303,
-0.010909989,
-0.006490753,
-0.0018199756,
-0.014309907,
0.010679821,
-0.01358652,
0.011120428,
0.012113442,
0.03161858,
0.0023214142,
0.008154542,
0.0019284836,
-0.015480478,
0.021425404,
-0.023227293,
0.010752159,
-0.02675216,
0.012402796,
0.005800247,
-0.00835183,
-0.006388821,
0.017874232,
0.0010316483,
0.03674805,
0.035906292,
-0.0037912047,
0.03790547,
0.015125361,
0.010752159,
0.010357584,
-0.009154132,
-0.015006989,
-0.0011927662,
0.011015208,
0.004606659,
0.020596797,
-0.022701195,
-0.006543363,
-0.008180847,
-0.0103181265,
0.020044392,
-0.01939992,
0.010114263,
-0.013290589,
0.00087710656,
-0.0256342,
0.0037385947,
-0.009798603,
0.0070826146,
-0.009851214,
0.00640855,
0.014862311,
0.02309577,
-0.01099548,
-0.008417592,
0.028356764,
0.0046987263,
0.01559885,
0.013356351,
0.017321827,
0.008279491,
-0.01192273,
0.029382657,
0.011271683,
-0.0025976163,
0.006701193,
0.00006134403,
0.0046395403,
0.01342869,
0.013119607,
0.016322238,
0.020320594,
0.0062836013,
-0.0014393755,
0.013981095,
0.011344021,
-0.018216196,
0.008838472,
0.002747226,
-0.022635432,
0.0028376493,
0.021241268,
0.03424908,
0.0005293876,
0.041430335,
-0.006497329,
-0.009351419,
0.005172216,
-0.012593507,
0.0072667496,
-0.010587753,
0.020136459,
-0.0052774358,
-0.014822854,
-0.022661736,
-0.03885245,
0.015559393,
-0.01099548,
0.014612414,
0.0034689687,
0.01786108,
0.010469381,
0.0073982747,
0.0132577075,
0.0070300046,
-0.046954382,
0.017348131,
0.0222014,
0.011225648,
-0.005307029,
0.010351008,
0.010193178,
0.006464448,
0.014296754,
0.024989728,
-0.0013900535,
-0.017308675,
0.016953558,
0.0057016034,
-0.013823265,
0.0024973287,
-0.024726678,
0.015348953,
-0.01786108,
-0.0063230586,
-0.018860668,
0.00013799837,
-0.0035873412,
0.003774764,
-0.004504727,
-0.006106043,
-0.016624745,
-0.00824661,
-0.0039424584,
0.010798193,
0.0030217841,
-0.0070037,
-0.022582822,
0.00782573,
0.012784218,
-0.010140568,
0.003639951,
0.015743528,
0.004179203,
0.01797945,
-0.027935885,
0.011113852,
-0.003797781,
0.037879165,
0.004064119,
-0.0050374027,
0.012126594,
0.015612003,
0.016716812,
-0.0117320195,
-0.012297576,
-0.004912454,
-0.0043830667,
-0.0084307445,
0.004340321,
0.009029183,
0.012567203,
0.017137691,
0.039194413,
-0.01033128,
-0.026988905,
-0.015085904,
-0.020609949,
-0.014020552,
0.0022540076,
0.056345258,
0.018045213,
0.0076679005,
0.0017838061,
0.005264283,
0.03156597,
0.004018085,
0.015769834,
0.0008729964,
-0.0009732841,
-0.024029596,
0.029461574,
0.003906289,
-0.021109743,
0.011271683,
-0.00674065,
0.017321827,
0.019899715,
0.007976984,
0.014928074,
-0.005231402,
-0.0075758332,
0.008923963,
-0.029540488,
-0.014796549,
0.0082005765,
-0.006852446,
-0.021767369,
0.004560625,
-0.004337033,
-0.024831897,
-0.03503823,
0.0062737367,
-0.00079901365,
-0.020978218,
0.0052741477,
-0.005264283,
-0.006872175,
-0.0076942053,
-0.003965475,
-0.000540074,
-0.0049387594,
-0.015085904,
-0.008226881,
-0.028725034,
-0.03198685,
-0.011041514,
-0.0073653935,
-0.0052741477,
-0.002556515,
-0.028409375,
-0.0013218251,
0.0054319776,
-0.0070037,
0.017966298,
-0.019728731,
-0.008095357,
0.017321827,
-0.0075626806,
0.012054255,
-0.017505962,
-0.026199756,
-0.0008434033,
-0.0019860256,
-0.02104398,
-0.022688042,
-0.010101111,
0.024016444,
0.024989728,
-0.0074574607,
0.022595974,
-0.011646528,
0.010153721,
0.0022671602,
-0.016006578,
0.013389233,
0.0020632965,
-0.012521168,
0.011376902,
-0.010429923,
-0.013494452,
-0.03832635,
0.004958488,
-0.0020583645,
-0.016269628,
-0.010423346,
-0.004277847,
0.00015556927,
-0.0025943283,
-0.02188574,
-0.005912043,
-0.013224827,
0.025594741,
0.008845048,
-0.00047307854,
0.03393342,
0.015993426,
0.00013316894,
-0.0045967945,
0.032802306,
0.016453762,
0.002747226,
-0.011455817,
0.014901769,
0.005507604,
-0.008049322,
-0.036616527,
0.016348543,
0.0064578718,
0.04003617,
0.00074270455,
-0.008845048,
-0.04513934,
-0.01041677,
-0.019952325,
-0.00980518,
-0.009634198,
-0.018281959,
-0.020649407,
0.0093711475,
-0.004521168,
-0.026502263,
0.02309577,
-0.03293383,
0.0006703659,
0.006155364,
0.00082326354,
-0.00012751749,
-0.009068641,
-0.012054255,
0.0038405266,
0.0054385536,
-0.024029596,
-0.030882042,
0.0050308267,
-0.013389233,
0.037247848,
0.013198522,
0.032960135,
-0.007996713,
0.015099056,
0.0047875056,
-0.0143230595,
0.020531034,
-0.02235923,
0.012659269,
0.0032256476,
0.046112623,
0.0006177559,
0.0019054667,
0.029224828,
-0.0069182087,
0.036932185,
-0.012067407,
-0.015664613,
-0.030040283,
-0.017913688,
-0.018886972,
-0.028304154,
0.023332514,
0.0007250309,
0.017571723,
-0.0428245,
0.008621456,
0.020965066,
0.027672835,
-0.000512125,
0.0017196878,
0.012435677,
-0.009160708,
0.00019502673,
-0.009548706,
0.004021373,
0.01897904,
-0.022254009,
-0.0013218251,
-0.035511717,
0.006171805,
0.016835185,
0.0030300044,
0.032539256,
-0.011745172,
-0.01903165,
0.0006654337,
-0.0070168525,
0.008121661,
-0.0026551585,
-0.033696674,
-0.017413894,
-0.015875053,
-0.0036070698,
-0.0038964245,
-0.00021187836,
0.0014862311,
-0.010285245,
0.028172629,
-0.015177971,
-0.029514182,
-0.022806413,
-0.0117320195,
0.005149199,
-0.0138495695,
0.018203044,
0.008259762,
-0.016558982,
-0.0005503494,
0.0023789562,
-0.004984793,
0.005573367,
0.013599672,
0.032118376,
-0.009154132,
-0.0149149215,
0.007970408,
0.009686807,
-0.043008637,
-0.028961778,
0.032434035,
0.00516564,
0.0026025486,
-0.007832306,
-0.040246613,
-0.028751338,
0.043166466,
-0.009706536,
0.0027094125,
0.017834773,
-0.045428693,
-0.0036235105,
0.015980273,
-0.021977808,
0.008812167,
0.016401153,
0.0014599261,
0.0020632965,
0.02178052,
-0.021293879,
0.014480889,
-0.019202633,
0.03240773,
0.008338678,
0.0053859437,
0.024884507,
-0.0053333337,
-0.0048960135,
-0.0029675302,
-0.005954789,
0.033644065,
0.011133581,
0.0041857795,
0.0023345666,
-0.006415126,
0.018281959,
-0.016690508,
-0.010351008,
-0.022109332,
-0.02288533,
-0.016979862,
0.020083848,
0.010495685,
-0.019662969,
0.013402386,
-0.02431895,
-0.014349365,
0.013494452,
-0.028672423,
0.008128238,
-0.02631813,
0.0059942463,
0.0028212087,
-0.004425812,
0.010660091,
0.016927252,
0.0008376491,
0.0017575012,
0.0020583645,
-0.011679409,
0.0015610359,
0.01411262,
0.0071352245,
-0.019110564,
-0.0039950684,
-0.044323884,
-0.0119687645,
-0.0036103579,
0.0065795323,
-0.0359589,
-0.029540488,
-0.015006989,
0.014665024,
0.021228116,
-0.035406496,
0.017584877,
-0.009265928,
0.0015059599,
-0.009561859,
0.0066387183,
0.0072601736,
-0.011324292,
0.031171396,
0.033275794,
-0.014954379,
-0.012481711,
-0.0041989316,
0.010173449,
-0.028619815,
0.0013653927,
-0.0022836006,
-0.0073719695,
0.0062309913,
-0.0011516648,
-0.010219484,
0.001427045,
-0.0072207158,
-0.022898482,
0.011515004,
0.020583645,
-0.023174684,
0.018018909,
-0.017479656,
-0.027988495,
0.0080756275,
-0.023240447,
-0.009653926,
-0.022543365,
0.00430744,
-0.016690508,
0.01644061,
-0.02733087,
0.04550761,
0.0110283615,
0.0013842994,
-0.021754215,
-0.024463627,
-0.03848418,
0.020478424,
-0.010745583,
0.031092482,
0.0124422535,
0.008180847,
0.010041924,
0.027304566,
-0.012869709,
-0.009397453,
0.0019449241,
0.0075692567,
0.016848337,
-0.035643242,
0.0045672012,
0.0006600905,
-0.05429347,
-0.02764653,
0.02526593,
-0.011080971,
-0.020386357,
-0.0012511304,
-0.002211262,
0.0037418827,
-0.019202633,
-0.010758735,
-0.016269628,
0.0031582413,
0.032854915,
-0.020504728,
-0.015362106,
0.013783808,
0.00037032473,
-0.0077270865,
0.012001646,
0.01840033,
0.013132759,
-0.0050768605,
-0.01807152,
0.0028984796,
-0.014665024,
-0.01701932,
0.0027077685,
0.009344842,
-0.0050538434,
0.03151336,
0.0010661735,
-0.0103247035,
-0.017703248,
0.0018413484,
0.010909989,
-0.0061389236,
0.0075561046,
0.0069313613,
-0.0096078925,
0.0034295113,
0.013836417,
-0.008588575,
-0.00014899303,
0.012955201,
-0.008628032,
-0.015322649,
0.035853684,
0.003422935,
0.0009683519,
-0.02463461,
0.00003424271,
-0.025094947,
-0.030382248,
-0.018689685,
-0.006799836,
-0.023766546,
-0.0023247022,
0.01239622,
-0.02157008,
0.015927663,
0.007904645,
-0.036616527,
-0.028304154,
0.014388822,
0.18287219,
-0.0034689687,
-0.02066256,
0.019794494,
-0.013704892,
-0.0083123725,
0.018281959,
0.005524045,
-0.012271271,
0.012494864,
0.021109743,
0.01078504,
-0.020478424,
0.00041718048,
0.016861489,
-0.004212084,
-0.017571723,
-0.017676944,
-0.0035347312,
-0.009206742,
-0.0058627217,
0.006352652,
0.008259762,
-0.00039251958,
0.025699962,
-0.0017098235,
-0.00015413071,
0.015625156,
0.019110564,
-0.024450475,
-0.0065663797,
-0.020465272,
-0.0062375674,
0.01628278,
-0.016164407,
-0.0076350193,
-0.012521168,
-0.0050275386,
0.0029280726,
0.0032782576,
-0.035432804,
0.03288122,
-0.018097823,
0.010633786,
-0.019018497,
0.03722154,
-0.001750925,
-0.012849981,
-0.005464859,
-0.0057311966,
-0.052110158,
0.0031631733,
-0.008687219,
-0.0035380193,
-0.013191946,
-0.0054549943,
0.05524045,
0.0017147557,
-0.0006666667,
-0.0052938764,
0.007746815,
0.01250144,
-0.013303742,
0.011784629,
-0.010686397,
-0.00856227,
-0.02130703,
0.026041927,
0.0056851627,
0.006543363,
-0.0043534734,
-0.0023345666,
-0.02547637,
0.026594331,
-0.0019728732,
-0.033328403,
-0.0038569672,
0.024989728,
0.0025285657,
0.011080971,
0.0062770247,
-0.023332514,
-0.018439788,
0.011271683,
-0.029514182,
-0.031039871,
0.01390218,
0.008279491,
-0.0013686807,
-0.003209207,
0.006066585,
0.00015690507,
-0.012100289,
0.0042712707,
0.03146075,
0.015677765,
-0.010114263,
0.019886563,
-0.021754215,
0.012534321,
-0.04392931,
0.09022607,
0.0017657215,
0.0113834785,
0.0071286485,
0.004984793,
-0.034643654,
0.013823265,
-0.006385533,
0.014401974,
-0.015822442,
-0.014888616,
-0.012461983,
-0.01939992,
0.00420222,
0.007464037,
-0.01649322,
-0.031644884,
0.02869873,
-0.042114265,
-0.020531034,
-0.036721747,
0.012942048,
0.029698318,
-0.017519115,
0.020412661,
-0.012277847,
-0.009127826,
-0.0011985204,
-0.026199756,
0.009075217,
-0.00054870534,
0.0009420469,
-0.0031089194,
0.026423348,
-0.0116136465,
0.004606659,
-0.013395809,
-0.012481711,
0.04366626,
-0.017834773,
0.010173449,
0.018847516,
0.011764901,
-0.008213729,
0.0026666669,
0.02157008,
-0.016401153,
-0.03309166,
-0.019373614,
-0.016059188,
-0.0017920265,
-0.0057739425,
-0.009943281,
0.025713114,
-0.0048302514,
-0.00074229355,
-0.05016359,
0.0169141,
0.01971558,
-0.0512684,
0.0056785867,
0.041851215,
-0.023924375,
-0.004554049,
-0.0091409795,
-0.16414306,
0.008503083,
0.026988905,
-0.000117858624,
0.041298814,
0.0033900538,
0.028725034,
-0.010147144,
-0.019123718,
0.00689848,
0.011429512,
0.007602138,
-0.01797945,
-0.017269216,
0.013448419,
0.009219894,
-0.009884095,
0.02631813,
0.030882042,
0.024029596,
0.029750928,
-0.01924209,
0.029803539,
-0.027830664,
0.013040692,
0.010771887,
-0.009094945,
-0.002130703,
-0.004669133,
0.011824086,
-0.013073573,
-0.016835185,
0.03832635,
-0.013941637,
0.015519936,
0.012258119,
-0.0022572957,
0.0155067835,
-0.014862311,
0.028567204,
0.040562272,
0.036511306,
-0.0033111388,
-0.0038832722,
-0.016059188,
0.024910811,
0.018426636,
-0.011738596,
0.02780436,
0.00225894,
0.013941637,
-0.006517058,
-0.0008277847,
0.012120018,
0.014533499,
0.02754131,
0.012284424,
0.0012100289,
0.008647761,
-0.016111799,
-0.0055141808,
-0.014309907,
0.012481711,
0.010673244,
-0.0026880398,
-0.025699962,
-0.009989315,
-0.018913278,
-0.0019712292,
0.003824086,
-0.034748875,
0.00022934651,
0.008621456,
-0.004577066,
0.036432393,
0.01580929,
-0.017334979,
-0.0012577067,
0.0019975342,
0.014520347,
0.008976573,
0.009213318,
-0.029882453,
-0.011133581,
0.010811345,
0.017939994,
0.04742787,
-0.010587753,
0.003426223,
-0.03230251,
0.02780436,
-0.017532267,
0.025765724,
-0.028593509,
0.014494042,
0.022017265,
0.022135638,
-0.00045417185,
0.014941227,
-0.024989728,
0.02717304,
-0.014572957,
-0.023503495,
-0.020741474,
0.02669955,
-0.015322649,
-0.0032207156,
0.002510481,
0.041877523,
-0.018479245,
-0.009180437,
0.006392109,
0.015782986,
0.003018496,
-0.0026058366,
0.0070300046,
-0.012981506,
-0.009318538,
-0.026686398,
-0.015572546,
0.052741475,
0.026449654,
0.011692562,
0.031118786,
-0.010923142,
-0.016269628,
-0.12079245,
-0.014743939,
-0.0058956025,
-0.014520347,
-0.013316894,
0.012882862,
-0.0056489934,
0.0059482125,
-0.0037024254,
0.020846693,
0.000996301,
-0.013422114,
-0.0031615293,
-0.0053530624,
0.04032553,
-0.0028458696,
0.030224418,
-0.01776901,
-0.013362927,
0.048611596,
0.0034558163,
0.022793261,
0.0116202235,
-0.020175917,
-0.00225894,
-0.011758325,
-0.008305796,
0.0026041926,
0.0053990963,
0.02733087,
-0.0031418006,
0.0020337035,
0.017006166,
-0.00077640783,
-0.021320183,
-0.009305385,
-0.011015208,
-0.04371887,
0.0051919445,
-0.038352653,
0.008555694,
0.011797782,
0.024608305,
-0.010863955,
0.00091409794,
-0.010811345,
-0.03780025,
0.011889849,
0.009272504,
-0.030198112,
-0.008963421,
-0.0269626,
0.0038207977,
0.013237979,
0.025397453,
-0.004771065,
0.010383889,
0.008654337,
-0.009792027,
0.0022293467,
-0.008917387,
-0.002827785,
-0.00695109,
0.011449241,
0.00091409794,
-0.026923142,
-0.017361283,
-0.030355942,
-0.0021224828,
-0.026620636,
-0.0103247035,
0.011725443,
-0.009292233,
-0.009903823,
-0.040299222,
-0.0274887,
-0.0025187014,
-0.008411016,
0.012277847,
-0.012514592,
-0.012968353,
-0.021280726,
0.016769422,
-0.007306207,
0.034538433,
0.025016032,
0.008706947,
-0.014309907,
-0.010429923,
-0.035064533,
0.0073785456,
0.041219898,
0.010870531,
-0.027199345,
-0.028146325,
0.00102425,
0.00948952,
-0.023858612,
0.024147969,
0.021320183,
-0.005744349,
-0.008845048,
-0.061606254,
0.009213318,
0.0017427047,
-0.00334402,
0.018255653,
0.0061619407,
0.053793676,
0.014375669,
-0.013191946,
-0.00037792852,
-0.026541721,
0.008371559,
-0.008391287,
-0.005468147,
-0.00015485,
-0.008194,
0.005448418,
0.024082206,
0.015612003,
0.03203946,
-0.0033621048,
0.0058824504,
0.02363502,
0.0021981096,
-0.00302014,
-0.0020928897,
0.017150844,
-0.0022178383,
-0.031145092,
0.0096078925,
0.017071929,
-0.0073653935,
0.00059473905,
-0.0064019733,
-0.026291823,
-0.020846693,
-0.0056917393,
0.020767778,
0.011455817,
0.009851214,
-0.0072930544,
-0.01845294,
0.02869873,
-0.029066999,
0.008766133,
0.008476779,
-0.024568848,
0.021951502,
0.004777641,
0.013678588,
-0.008752981,
-0.00042129064,
-0.0046789977,
-0.0071746823,
-0.010712702,
0.0063690925,
-0.0019778053,
0.006707769,
-0.045323472,
-0.03309166,
0.017808469,
-0.011015208,
-0.004563913,
0.0049453354,
0.01913687,
0.0050012334,
-0.016046036,
0.011304564,
0.02321414,
-0.040141392,
-0.04382409,
0.006013975,
-0.020097002,
0.0008142212,
0.015717223,
-0.008838472,
-0.002883683,
0.021030828,
-0.00003257296,
0.0065893964,
0.014152077,
-0.017137691,
-0.034327995,
0.013297166,
0.005576655,
-0.009292233,
-0.032907523,
-0.010896836,
0.015835596,
0.0031582413,
-0.020583645,
0.025344845,
0.00039971233,
0.018110976,
-0.021912046,
0.011843815,
0.003048089,
0.009094945,
0.0019350598,
0.018689685,
-0.0056424174,
0.014362517,
-0.007970408,
-0.022069875,
-0.02500288,
0.006701193,
-0.01654583,
-0.029935062,
-0.017295523,
0.025660504,
0.017427046,
0.03246034,
-0.0025450063,
-0.0017936706,
0.018124128,
0.009167284,
0.015743528,
0.011784629,
-0.0062967534,
0.034985617,
0.007444308,
0.025357997,
0.014178382,
0.015546241,
0.04392931,
0.010035348,
0.031408142,
-0.022766957,
0.031381838,
0.0009732841,
0.0064841765,
-0.032749694,
-0.033591453,
0.0020156188,
0.0029428692,
-0.021241268,
0.008470202,
0.006224415,
0.0014426635,
0.08228196,
0.022385534,
-0.0008405262,
-0.01670366,
-0.012001646,
0.019386766,
0.016611593,
0.026186604,
-0.00091409794,
-0.031750105,
0.016032882,
-0.015901359,
0.026383892,
-0.041509252,
-0.009042336,
0.008713523,
-0.0009938349,
0.01738759,
0.0044060834,
-0.0055404855,
0.009870943,
-0.004235101,
0.021136047,
0.02358241,
-0.025121253,
0.0010045213,
0.02452939,
0.009621045,
-0.021714758,
-0.022898482,
-0.019202633,
-0.002799836,
-0.023937529,
-0.015480478,
0.04045705,
-0.015204276,
-0.010673244,
-0.03758981,
0.008654337,
0.004478422,
-0.00017889439,
-0.0012618168,
-0.013941637,
-0.037274152,
-0.017505962,
-0.012337034,
-0.02109659,
0.00028524458,
-0.014270449
] |
New neurons are generated in the adult hippocampus throughout life by neural stem/progenitor cells (NSCs), and neurogenesis is a plastic process responsive to external stimuli. We show that canonical Notch signaling through RBP-J is required for hippocampal neurogenesis. Notch signaling distinguishes morphologically distinct Sox2(+) NSCs, and within these pools subpopulations can shuttle between mitotically active or quiescent. Radial and horizontal NSCs respond selectively to neurogenic stimuli. Physical exercise activates the quiescent radial population whereas epileptic seizures induce expansion of the horizontal NSC pool. Surprisingly, reduced neuro | [
-0.02323626,
0.020392379,
0.009960323,
-0.0052059195,
-0.024206685,
0.0020065536,
-0.0030258356,
0.0075410022,
-0.013390502,
-0.022117577,
0.015203307,
0.0009780054,
-0.0061291703,
-0.00599102,
-0.009771629,
-0.008518165,
0.036148287,
0.0071231807,
0.010566838,
0.025244499,
-0.022858873,
0.02687535,
0.027212303,
-0.018222405,
0.0017622628,
0.02031151,
0.0044511454,
-0.017804582,
-0.0046735345,
-0.018640226,
0.0005243827,
0.01660503,
-0.00011814405,
-0.006267321,
-0.004842011,
-0.0071231807,
-0.0038109354,
-0.024840156,
0.011800084,
0.018734572,
0.008214908,
-0.0045084273,
-0.019058047,
-0.0014665867,
-0.002515352,
-0.0070962245,
-0.033883967,
-0.011503566,
0.005209289,
0.033048324,
0.03329093,
0.008309254,
-0.004548862,
0.010957703,
-0.010944225,
-0.023923645,
0.015742432,
0.01989369,
0.022414096,
-0.02544667,
0.009913149,
0.019974558,
-0.017791104,
0.025204064,
-0.006146018,
0.015863735,
-0.0023468758,
-0.00082721893,
0.012595293,
0.0050846166,
0.026363181,
0.01382854,
-0.035096996,
0.004036694,
0.012790726,
-0.014745052,
-0.021335848,
-0.017925885,
-0.005745044,
0.0017858495,
0.0051418985,
-0.04512471,
-0.009892932,
0.040892582,
0.011961822,
0.01190791,
-0.015931126,
0.010728575,
-0.0020941612,
0.0140037555,
0.014286796,
0.03927521,
0.01640286,
-0.0078105642,
0.009084246,
-0.0008196375,
-0.00013099037,
0.0070894854,
-0.0027714362,
0.007359048,
-0.036822196,
0.017791104,
-0.0032515938,
-0.020419335,
-0.0140037555,
-0.008363167,
0.0018363924,
0.0050576604,
0.02808838,
0.006102214,
-0.0067053596,
0.025271455,
-0.019448912,
-0.04596035,
0.02922054,
0.003662676,
0.029840535,
0.020203685,
-0.0005521813,
-0.01047249,
0.033803098,
0.015445913,
0.020163251,
-0.027549256,
0.0007712006,
0.027980555,
0.0012357741,
0.012790726,
-0.029975316,
-0.003999629,
-0.01760241,
-0.006395363,
-0.021874972,
0.030217921,
-0.021268457,
0.012008996,
0.007945346,
0.002259268,
-0.029570973,
-0.029597929,
-0.01175965,
0.019475868,
-0.01974543,
0.004441037,
0.0057484135,
0.03202399,
0.00934033,
0.017440673,
0.029624885,
0.0018903048,
-0.00036664668,
-0.00955598,
0.022710614,
-0.021767147,
0.0013469686,
0.023613647,
-0.0007657251,
0.020634985,
0.0057922173,
-0.0154863475,
0.010000757,
-0.013794845,
0.0012383013,
0.004555601,
0.008740554,
0.016766768,
0.012211167,
-0.010149016,
0.016079385,
-0.014152015,
-0.009603153,
0.024408856,
-0.025298411,
0.011368785,
-0.0032448547,
0.005023965,
0.016456772,
0.0021514432,
-0.025635364,
0.009117941,
-0.015055048,
0.013936365,
0.00021754511,
0.018936744,
-0.011550739,
-0.0074466555,
0.032212682,
-0.01795284,
-0.010357927,
0.004626361,
-0.01432723,
0.011004876,
-0.023465388,
-0.020109339,
-0.6227965,
-0.0107555315,
0.02908576,
-0.022575833,
0.03442309,
0.0216728,
-0.009178593,
0.0045454926,
-0.026241878,
0.0091314195,
-0.02095846,
0.031538777,
0.024853634,
0.010560099,
-0.027010132,
-0.018155012,
-0.0072512226,
-0.0043500597,
0.041216057,
0.0041243015,
-0.009603153,
-0.018438054,
-0.0016519107,
0.03649872,
0.012008996,
0.03940999,
0.028762285,
-0.011523783,
-0.008504687,
0.027279694,
-0.0047105993,
0.007278179,
-0.005667545,
-0.0049228794,
0.046661213,
0.0095425015,
-0.011126179,
0.033129193,
-0.0053070057,
0.014354186,
-0.011517044,
-0.0016889756,
0.02288583,
-0.012062908,
-0.033803098,
0.0051857023,
-0.0030477375,
0.00095357624,
-0.013579195,
-0.021281935,
0.018478489,
0.0011111016,
-0.029786622,
0.0077229566,
0.016982418,
-0.006779489,
-0.0033038214,
-0.011463132,
0.017656323,
0.015998516,
0.006139279,
0.00976489,
-0.04126997,
-0.015445913,
0.0024176359,
0.022643223,
-0.0149472235,
-0.015014614,
0.005411461,
-0.025244499,
0.0046229917,
0.005263202,
-0.012217906,
-0.015432435,
0.009643587,
0.0076960004,
0.012965941,
0.008673163,
-0.005269941,
0.013323111,
0.0039187605,
-0.009502067,
-0.03442309,
-0.004579188,
0.011079006,
-0.014583314,
-0.01640286,
0.013666803,
-0.005118312,
-0.00662786,
-0.0018448163,
0.0039019126,
0.00299551,
-0.05426287,
-0.009016855,
0.005209289,
0.0061830827,
0.026147531,
0.014515923,
-0.036903065,
-0.007507307,
0.009104463,
-0.0041040843,
0.008605773,
0.00841034,
0.0047678812,
-0.027926642,
0.004333212,
0.041108232,
-0.02787273,
0.0031639861,
0.004855489,
-0.014381142,
0.0065469914,
-0.0037907183,
-0.020365423,
0.028950978,
0.0013848757,
-0.0010378144,
-0.017777625,
0.014529401,
-0.0077296956,
-0.017831538,
-0.010593794,
0.034396134,
0.010324231,
-0.00948185,
0.019516302,
-0.011961822,
-0.019664561,
-0.0126492055,
-0.02195584,
0.028169248,
-0.011820301,
0.020554116,
0.022494964,
0.0010664554,
0.005687762,
0.021201067,
-0.03264398,
-0.026147531,
0.00962337,
0.006520035,
-0.015526782,
-0.0047004907,
-0.0030746937,
-0.018923266,
-0.0072242664,
-0.0060078674,
-0.0019998145,
-0.00043719617,
-0.015189829,
-0.022090621,
-0.005940477,
0.015499826,
-0.0051621157,
-0.032967456,
-0.007170354,
0.0016443293,
-0.0069412263,
-0.008019475,
0.040218677,
-0.006584056,
0.021524541,
-0.031673558,
-0.018491967,
-0.0060988446,
0.013498327,
0.029409235,
-0.021524541,
-0.004976792,
0.005101464,
-0.0075746975,
0.009259461,
0.010115321,
0.0016771823,
-0.013248981,
0.015122439,
-0.008012736,
-0.0006966498,
-0.015648086,
-0.036633503,
0.0007185517,
-0.010647707,
0.035663076,
0.014178971,
0.031323127,
0.010108582,
0.016416337,
0.013511805,
0.002702361,
0.033263974,
-0.014030712,
0.0007834151,
-0.0006637969,
-0.04690382,
0.0076825223,
0.012251602,
0.015728954,
0.02986749,
-0.0025962207,
-0.015014614,
0.009326852,
-0.00869338,
0.033803098,
-0.028843153,
-0.016011994,
-0.02424712,
-0.008962942,
0.021699756,
0.0047678812,
0.017898928,
-0.0024479616,
-0.016483728,
-0.021497585,
-0.0020234012,
-0.012413339,
0.0036222418,
-0.007183832,
-0.011085745,
0.005431678,
-0.011173353,
-0.0056641754,
0.0024395378,
0.011112701,
0.044019505,
0.015149395,
0.018505445,
0.0006296804,
-0.023910167,
0.0030275204,
0.031107476,
-0.010452273,
0.011126179,
-0.005333962,
0.024584072,
-0.0076757832,
-0.0066851424,
0.005216028,
0.011517044,
0.023061045,
0.0064256885,
-0.017494585,
0.006230256,
-0.0080531705,
-0.013370285,
0.038682174,
0.0050576604,
-0.011658564,
0.0005930368,
-0.01675329,
0.0015794659,
-0.015028092,
-0.0031909423,
-0.0022778006,
-0.012992897,
0.0054990686,
0.007648827,
0.021901928,
0.031889208,
0.0036188723,
0.009084246,
-0.0067997063,
-0.014421577,
0.0029584449,
0.011436176,
0.030999651,
-0.0083159935,
-0.022562355,
-0.012083125,
-0.01738676,
-0.004127671,
-0.0088551175,
-0.03377614,
0.0052463543,
-0.01147661,
0.01033097,
-0.0039254995,
0.011045311,
0.009259461,
0.010310753,
-0.01219095,
0.016591553,
0.0316466,
-0.01247399,
-0.00043003593,
-0.030002272,
-0.029274452,
-0.019704996,
-0.0001532082,
-0.0022036708,
0.019138915,
-0.018923266,
-0.0074062212,
-0.021794103,
-0.0127772475,
0.004077128,
0.0032229528,
-0.0018380772,
-0.020257598,
0.0069614435,
0.0005517601,
-0.018936744,
-0.017966319,
0.013963321,
0.011523783,
-0.0069479654,
-0.005822543,
-0.028600547,
-0.017777625,
0.0038378916,
-0.002645079,
0.0071164416,
-0.0018650334,
-0.0034234398,
-0.0071299197,
0.010593794,
0.0060213455,
0.016025472,
0.011038572,
-0.024853634,
-0.029597929,
-0.015958082,
-0.03714567,
0.042725608,
0.00727144,
-0.009953584,
0.014300274,
-0.012022474,
-0.011611391,
-0.014502445,
0.024220163,
0.03029879,
-0.024179729,
-0.0048858146,
0.0012770508,
0.0075746975,
-0.0031774642,
0.0029348582,
0.019880211,
0.00876751,
-0.010290536,
-0.010317492,
-0.023937123,
0.006011237,
0.015809823,
0.0072444836,
0.041970834,
0.017871972,
0.0095357625,
0.020298032,
0.008652946,
0.018316751,
0.00074466557,
0.0049228794,
0.0074062212,
0.011045311,
0.011442915,
0.009731195,
-0.025837535,
0.013815062,
0.016241122,
0.0061291703,
-0.008093605,
0.02715839,
-0.0003337938,
0.029894447,
-0.011234004,
-0.008080127,
0.009030333,
0.0070760073,
0.011287916,
-0.018074144,
-0.010674663,
0.024503203,
-0.033317886,
-0.022184968,
-0.0074331774,
0.00876751,
-0.00020754183,
0.014745052,
-0.011234004,
-0.006338081,
-0.013639847,
-0.013033331,
-0.011800084,
0.015796345,
-0.0131142,
-0.008241864,
-0.028816197,
0.021659322,
-0.009212288,
-0.026834916,
-0.01018945,
0.010438795,
-0.007332091,
-0.046769038,
0.018855875,
0.0044073416,
0.03636394,
0.0383587,
-0.0023114958,
-0.008241864,
0.025325367,
0.010162494,
-0.036148287,
-0.012224645,
-0.010391622,
0.020432813,
0.023829298,
-0.0025776883,
-0.015836779,
0.0019998145,
-0.0040804977,
0.046580344,
-0.017966319,
0.021241501,
-0.012305514,
-0.012130299,
0.008302515,
0.03385701,
0.016079385,
0.010600533,
-0.0074533946,
-0.016591553,
-0.027630124,
-0.011058789,
-0.021645844,
-0.0135455,
-0.009973801,
-0.00088365853,
0.0148124425,
-0.022184968,
-0.012217906,
0.025999272,
-0.019691518,
0.019287175,
-0.0008579659,
-0.0045522316,
0.013107461,
0.02396408,
0.012797465,
0.011308134,
-0.008666424,
0.020149773,
-0.007972302,
0.0316466,
-0.017184589,
-0.02758969,
-0.013093983,
-0.0044578845,
0.0037873487,
-0.029274452,
0.03477352,
-0.0149472235,
0.032967456,
-0.003337517,
-0.034126572,
-0.017845016,
-0.018087622,
0.0038008268,
0.012029213,
0.0022862244,
-0.008956203,
0.0025170369,
0.00039697243,
0.0027461648,
-0.01917935,
0.026134053,
-0.038870867,
-0.0012568337,
0.016726334,
0.0203789,
-0.017993275,
-0.023492344,
0.0085922945,
-0.0049734223,
-0.013282677,
-0.0027714362,
-0.029166628,
0.01382854,
-0.025702754,
0.019785864,
0.020500204,
0.041000407,
0.035016127,
-0.012231384,
0.015189829,
0.004100715,
-0.007008617,
-0.00013151686,
0.026767526,
-0.03498917,
0.03520482,
-0.02594536,
0.009953584,
0.024853634,
-0.008470992,
0.020971939,
0.04264474,
-0.00085501757,
-0.031997032,
0.0019206306,
-0.039463904,
-0.03108052,
0.012083125,
-0.011173353,
0.0047577727,
-0.019570215,
0.009117941,
0.027293172,
-0.0052665714,
-0.008841639,
-0.012305514,
0.017737191,
-0.025190586,
0.025217542,
-0.0026770895,
0.01839762,
-0.012871594,
-0.013451153,
0.0013739248,
-0.020621506,
0.02103933,
0.018343708,
0.009704239,
0.0053002667,
0.0035245256,
-0.0025861121,
0.007480351,
-0.02900489,
-0.008248603,
-0.019853255,
-0.032320507,
-0.023977557,
-0.028843153,
-0.0050576604,
-0.0056843925,
-0.005340701,
0.015068526,
-0.013195069,
0.020271076,
-0.005269941,
-0.00331393,
0.014987658,
-0.024112338,
0.031350084,
-0.011894432,
0.019004134,
0.01554026,
0.008599034,
-0.018316751,
-0.012487468,
-0.0048386413,
0.005886564,
0.056068935,
0.019152394,
-0.0051789633,
-0.016011994,
0.0035009389,
0.01911196,
-0.0067828586,
-0.015392001,
0.023424953,
0.0047038603,
-0.0047678812,
-0.0047105993,
-0.01297268,
-0.046014264,
0.007662305,
-0.013067027,
-0.000259243,
0.008403601,
-0.011806823,
-0.016375903,
0.027845774,
0.0071231807,
0.010270319,
0.019273696,
0.0004451988,
-0.018411098,
-0.0076892613,
-0.012292036,
0.022616267,
-0.009663804,
0.037523057,
-0.014515923,
0.0023199196,
0.0353396,
0.014731574,
0.001297268,
0.007817304,
0.0068772053,
0.03940999,
-0.0068199234,
-0.018060666,
0.028034467,
0.0059943893,
0.0034301789,
-0.012554859,
-0.015877213,
0.0012281927,
-0.026457528,
0.0015120754,
0.026026228,
-0.007480351,
-0.0060718884,
-0.01254812,
-0.03229355,
-0.018599791,
-0.041782137,
-0.01497418,
0.011099223,
-0.023478866,
0.0069816606,
0.007190571,
0.026201444,
0.012925507,
-0.006520035,
0.0124066,
0.003571699,
0.021767147,
-0.022441052,
0.015095483,
0.017791104,
0.031323127,
-0.017588932,
0.010930747,
0.012817682,
-0.015108961,
0.003699741,
-0.03822392,
-0.025541017,
0.028708372,
-0.0025760035,
0.036390897,
0.011557478,
0.006068519,
-0.00017921673,
0.019475868,
0.009205549,
0.004013107,
-0.02388321,
0.0057416745,
-0.01575591,
-0.009374025,
-0.014071146,
-0.02808838,
-0.019920645,
-0.027508821,
-0.007958824,
0.011395741,
-0.024894068,
-0.005879825,
-0.0027882839,
-0.0012787356,
-0.021052808,
0.00020459348,
-0.00890903,
-0.0039322386,
-0.028492723,
0.014057668,
-0.008599034,
-0.015863735,
-0.022252358,
0.031026607,
0.018842397,
-0.008565338,
-0.012467251,
0.00014552147,
0.01404419,
-0.036148287,
-0.04148562,
0.01233247,
-0.01283116,
0.023761908,
0.02951706,
-0.019381521,
0.0003516944,
-0.009360547,
-0.04604122,
-0.016551118,
0.011544,
0.0050441823,
-0.0014750105,
0.009994018,
-0.010822922,
-0.022764526,
-0.0033307779,
0.024139294,
0.0023333977,
0.005118312,
0.004447776,
-0.011874215,
-0.0004826848,
-0.0029348582,
-0.0084507745,
-0.007615132,
0.036471765,
-0.013633108,
-0.022373661,
0.018923266,
-0.031970076,
0.015135917,
-0.006075258,
0.02280496,
0.01946239,
0.021901928,
0.018855875,
-0.04447776,
-0.0009030333,
0.0028051315,
-0.0020082383,
-0.030703133,
-0.012163994,
0.015055048,
0.010634229,
0.004966683,
-0.030110097,
-0.022414096,
0.016915027,
0.0081273,
0.03905956,
0.023613647,
-0.0011717532,
0.022858873,
0.016524162,
-0.012339209,
-0.011072267,
0.007372526,
-0.006081997,
-0.005222767,
-0.009576197,
-0.021403238,
0.0015912593,
0.0017049809,
-0.00006765379,
-0.033910923,
0.008639468,
-0.0020065536,
0.007763391,
-0.026902307,
0.025204064,
-0.0017588933,
-0.030244878,
-0.019421956,
0.0034167008,
0.0014994397,
-0.012312253,
-0.0158233,
-0.01568852,
-0.027185347,
-0.007143398,
0.033237018,
-0.0029685537,
-0.015958082,
-0.007493829,
-0.0041040843,
0.0064694923,
0.019637605,
0.18071449,
-0.009367286,
0.011321612,
-0.014488967,
0.0075679584,
0.0034032227,
0.016362425,
0.0056911316,
0.00076740986,
-0.011287916,
-0.005852869,
0.011274438,
-0.013525283,
-0.0022188337,
0.018842397,
-0.024584072,
-0.009070767,
-0.012790726,
-0.0025423083,
-0.013491588,
0.0084507745,
-0.036687415,
0.00056945015,
-0.0007467715,
0.021982796,
0.0031353452,
-0.051055077,
0.017009374,
0.02644405,
0.012386383,
-0.024961459,
0.02273757,
-0.014556358,
-0.0012324046,
0.0037603925,
-0.007318613,
0.0026787743,
0.005822543,
0.010795966,
0.012413339,
0.03364136,
0.0019240001,
0.007190571,
0.01868066,
-0.0055765677,
0.0024395378,
0.010944225,
0.0064897095,
0.0032128443,
-0.02337104,
-0.05404722,
-0.0043669073,
0.01590417,
0.029490104,
0.004511797,
-0.002324974,
-0.011422697,
0.01795284,
-0.011725955,
0.034908302,
-0.018815441,
0.010897052,
-0.029813578,
0.023910167,
0.0077296956,
0.0138689745,
-0.014084624,
-0.0140037555,
0.019704996,
-0.007163615,
0.006024715,
-0.0006587426,
-0.032751806,
-0.014502445,
-0.0081812125,
-0.024274075,
0.032185726,
-0.00081331964,
0.015122439,
0.021214545,
0.026834916,
0.027980555,
-0.02252192,
-0.0059337374,
0.006570578,
-0.032778762,
0.028573591,
0.0031033347,
-0.042267352,
-0.0066918815,
0.030379659,
-0.0005702925,
-0.020136295,
-0.018882832,
-0.0038480002,
-0.022184968,
0.0017058232,
0.01903109,
-0.018815441,
-0.003421755,
-0.032751806,
0.07175745,
0.030972695,
0.016173732,
0.0034672436,
0.000019848621,
0.019354565,
0.021160632,
-0.008235125,
0.0034908303,
0.002901163,
-0.012554859,
-0.0015895745,
-0.009717717,
-0.011213787,
0.003955825,
-0.012339209,
-0.023532778,
0.054182,
-0.00684351,
-0.029139671,
-0.020756288,
0.00089208235,
0.033479623,
-0.016510684,
-0.008652946,
-0.0043736463,
-0.011530522,
0.0025557864,
-0.038089138,
-0.0019122068,
-0.019543258,
0.005468743,
0.01012206,
0.019098481,
-0.0060718884,
0.0018128057,
-0.0039625643,
-0.011254221,
0.024799721,
-0.02202323,
-0.01461027,
0.016861115,
0.006159496,
0.0144080985,
-0.01439462,
0.014259839,
0.0216728,
-0.005953955,
-0.030460527,
-0.0096975,
0.002431114,
0.010054669,
0.004154627,
0.011490088,
-0.025541017,
-0.022441052,
-0.040245634,
-0.021308891,
0.01233247,
-0.025541017,
0.00499027,
-0.013639847,
-0.01725198,
-0.004525275,
-0.023074523,
-0.16917723,
0.008376645,
0.034126572,
-0.041296925,
0.019974558,
0.024786243,
0.0070018778,
-0.011200309,
-0.008969681,
0.028681416,
0.03477352,
-0.009475111,
-0.028330985,
-0.023424953,
0.009165115,
0.016726334,
0.031323127,
0.024152773,
-0.000090503396,
0.02608014,
0.025419714,
-0.028708372,
0.037630882,
0.010411839,
0.026524918,
-0.015068526,
0.00033253024,
0.0027259476,
-0.003521156,
-0.021120198,
-0.019044569,
-0.008565338,
0.016564596,
0.015863735,
-0.00023460334,
0.0033493103,
0.00719731,
-0.01212356,
-0.011220526,
0.026659701,
0.013087244,
0.020783244,
0.00919881,
0.0037031106,
-0.019085003,
0.0162546,
-0.004447776,
-0.021915406,
-0.003002249,
-0.008875335,
-0.0040602805,
-0.0022778006,
-0.009508806,
0.02737404,
0.014448533,
-0.00020343521,
0.008275559,
0.01788545,
0.0009510491,
-0.008444035,
-0.004619622,
-0.0071029635,
0.025958838,
0.00084701495,
-0.0016097917,
-0.029193584,
0.005526025,
0.0036694154,
-0.036552634,
0.008524904,
-0.011604652,
-0.024637984,
0.0037098497,
-0.03202399,
0.011038572,
0.005360918,
0.0104051,
-0.006435797,
0.006766011,
0.022831917,
-0.003942347,
0.014825921,
-0.028330985,
-0.021281935,
-0.003662676,
-0.014583314,
0.013963321,
0.0071231807,
0.008464253,
0.000074024305,
-0.0018801963,
-0.03129617,
0.018545879,
0.013639847,
0.028681416,
0.0050711385,
-0.01175965,
-0.0039052821,
-0.0061055836,
0.008538382,
0.017642844,
0.004670165,
-0.018006753,
0.017346326,
0.041027363,
-0.011368785,
-0.030945739,
0.007305135,
0.05024639,
-0.00934033,
0.015230264,
0.010708358,
0.010007496,
0.018128056,
-0.0071164416,
0.040596064,
-0.003986151,
0.0037671316,
0.012399861,
-0.021241501,
0.07698696,
0.007278179,
-0.0020621507,
0.016726334,
0.010580316,
-0.032185726,
-0.13704541,
-0.041243013,
-0.015634608,
0.022872351,
0.005765261,
-0.0068974225,
-0.002837142,
0.020338466,
-0.017831538,
0.025069283,
-0.030837914,
-0.004107454,
0.010539882,
-0.018842397,
0.016375903,
-0.010459012,
0.010182711,
-0.001700769,
-0.007527524,
0.034315266,
-0.015243742,
-0.010870095,
-0.004198431,
-0.009279679,
0.0006692724,
0.022710614,
-0.035959594,
0.003578438,
0.0156211285,
0.005940477,
-0.0005854554,
-0.024274075,
0.031134432,
0.002345191,
-0.030244878,
-0.0068704663,
0.005067769,
-0.021160632,
0.023330607,
-0.0013671857,
0.00406365,
0.021942362,
0.035393514,
0.0072175274,
-0.0026939372,
-0.011557478,
0.010748792,
0.009084246,
0.014623748,
-0.01989369,
-0.03771175,
-0.013612891,
-0.016847637,
-0.007615132,
0.026781004,
0.00090977235,
0.014650704,
0.018694138,
-0.0029938251,
-0.014987658,
-0.0006958074,
0.0022120946,
-0.020796722,
-0.010128799,
0.038897824,
-0.0053103752,
-0.04776642,
-0.06038193,
0.0048453803,
-0.015028092,
-0.010337709,
0.0058124345,
-0.0116989985,
0.012453773,
-0.026134053,
0.014866355,
0.0032684414,
-0.012460512,
-0.0062572123,
-0.015890691,
-0.0118337795,
-0.016739812,
0.025864491,
-0.020082382,
0.01903109,
0.012022474,
0.0017403609,
0.008039692,
-0.0000037249072,
-0.0026164379,
-0.014839399,
0.012642466,
-0.0038581088,
-0.030137053,
-0.005610263,
0.00076404033,
0.009306635,
-0.006314494,
0.017130677,
-0.00046962788,
0.0035582208,
-0.026214922,
-0.041782137,
0.019085003,
-0.018491967,
-0.013410719,
-0.003044368,
-0.02202323,
0.00035148382,
-0.013356807,
-0.008255342,
-0.006739055,
-0.028411854,
0.0015937864,
0.012602032,
-0.0024496464,
-0.036956977,
-0.019085003,
0.028950978,
-0.009758151,
0.00033990107,
0.023263216,
0.016780246,
-0.010027713,
0.0034386027,
-0.020392379,
-0.009845759,
-0.012366165,
-0.0124066,
0.0038244135,
0.005333962,
0.0009283048,
0.012460512,
-0.043615162,
-0.013080505,
0.02758969,
-0.012238123,
-0.007284918,
0.010762271,
0.021659322,
0.01568852,
0.029813578,
-0.030595308,
-0.033048324,
0.0014000386,
-0.0052261367,
-0.022036709,
0.0064694923,
-0.04250996,
-0.0013183276,
-0.005546242,
-0.026942741,
0.035043083,
0.031565733,
0.0059505855,
-0.019260218,
-0.023950601,
0.0074196993,
-0.0075612194,
0.016847637,
0.0023468758,
-0.014435055,
-0.0010344449,
0.021147154,
0.015917648,
0.001076564,
-0.013383763,
-0.023047566,
-0.018128056,
0.0091314195,
-0.0049430965,
-0.01688807,
-0.023034088,
-0.0052800495,
0.03636394,
-0.005923629,
-0.0070692683,
-0.007500568,
-0.0024327987,
-0.026659701,
-0.033102237,
0.009865976,
-0.0031168128,
-0.0014556358,
-0.017332848,
0.024961459,
0.03666046,
0.0059168898,
-0.0049498356,
0.03108052,
0.018208927,
-0.0042287568,
0.005175594,
0.0064560142,
0.03151182,
0.015243742,
0.003571699,
0.013747672,
-0.02687535,
0.013842018,
0.004882445,
0.011456393,
-0.007648827,
0.020365423,
0.006210039,
-0.04188996,
0.014381142,
0.0111598745,
-0.03008314,
-0.011719216,
-0.0022643222,
-0.006493079,
0.0043938635,
0.017508063,
-0.012662684,
-0.0024580702,
-0.023344085,
0.00181786,
-0.0033964836,
-0.017871972,
-0.012575076,
0.0374961,
0.009010116,
-0.013909409,
0.0052059195,
0.0044208197,
0.029463148,
-0.006894053,
0.027791861,
0.0048925537,
0.017508063,
-0.022131056,
0.01675329,
-0.005879825,
-0.054235913,
-0.009427938,
0.0003933923,
-0.0442082,
-0.009259461,
0.018559357,
-0.025244499,
0.086098164,
0.02459755,
-0.015742432,
-0.0012172417,
-0.018599791,
0.0069344873,
-0.009448155,
0.024503203,
-0.019085003,
-0.030379659,
0.045313403,
-0.034746565,
0.02938228,
-0.040326502,
-0.0002092266,
0.008430557,
-0.019098481,
0.02702361,
0.01603895,
0.004555601,
0.013141156,
-0.019044569,
0.011752911,
0.0176698,
-0.020837156,
0.015648086,
0.03485439,
-0.038466524,
0.0054721124,
-0.0019189458,
0.0089898985,
0.013417458,
-0.05353505,
0.0035413732,
-0.009394242,
0.01497418,
0.0023165501,
-0.0102096675,
0.003130291,
0.031403996,
-0.0034739827,
0.0008495421,
-0.0020082383,
-0.027481865,
0.0009038757,
-0.013316372,
-0.007156876,
-0.0036593066,
-0.029678797
] |
Vitamin D may play a role in glucose metabolism. A low vitamin D level has been associated with increased risk of diabetes mellitus, but the association has not been confirmed in Asians. Our objective was to examine the association of serum 25-hydroxyvitamin D [25(OH)D] levels with insulin resistance and diabetes mellitus in Korean adults based on a large population-based survey. Cross-sectional analyses were carried out on 5787 Korean adults (2453 men and 3334 women) who were 20 y or older and participated in the Fourth Korea NHANES conducted in 2008. Diabetes mellitus was | [
-0.015127932,
-0.03712422,
0.021219213,
-0.04431845,
-0.030230796,
0.022873633,
-0.028927313,
-0.016569285,
-0.021169078,
-0.010572005,
0.0047501954,
0.011844155,
0.0005945578,
0.0053110695,
-0.026921954,
-0.006818223,
0.053492967,
-0.024302453,
0.007764502,
-0.016581817,
-0.023224572,
-0.008052772,
-0.0052014017,
0.007789569,
-0.00022462379,
0.010308802,
-0.00994533,
-0.037951432,
-0.000072753035,
-0.016318614,
0.027297959,
-0.0073822304,
-0.010327602,
-0.009851329,
0.016431415,
0.0012776335,
-0.011248814,
-0.022334693,
-0.0020147597,
-0.037475158,
0.012320428,
0.00033879612,
0.01042787,
0.00046491442,
0.007758235,
0.015503936,
0.031058008,
-0.015704473,
0.0030190062,
0.041084807,
-0.009932797,
0.03321377,
-0.010402803,
-0.024014182,
-0.007582766,
0.024816325,
0.015779674,
0.007062626,
-0.020279199,
-0.036196742,
-0.012564831,
0.004537126,
-0.01819864,
0.0050008656,
-0.0036033806,
-0.014200453,
0.009400124,
0.025969407,
0.015792208,
0.013874582,
0.014250587,
0.051988948,
0.0017625231,
0.0078146355,
0.034918323,
-0.0021996289,
-0.0111673465,
-0.01447619,
-0.0023327973,
-0.008848649,
0.020630138,
-0.016356215,
-0.016719686,
0.024878994,
0.004477592,
0.007507565,
-0.020981075,
0.019439455,
-0.0047595957,
-0.03446712,
-0.019978395,
-0.0009282622,
0.030431332,
0.01659435,
-0.019903194,
0.012640033,
0.0124081625,
0.026345411,
-0.0063795503,
0.012383096,
-0.013661512,
0.0022669963,
-0.021708017,
-0.019050917,
-0.008033972,
0.009989197,
-0.028325705,
-0.02340004,
0.009042919,
-0.018712511,
0.0042989897,
0.050760664,
-0.010221068,
-0.058606636,
-0.00086872804,
-0.0044305916,
-0.002769903,
-0.0063482164,
-0.020341868,
-0.00010986394,
0.018950649,
0.016118078,
0.013410843,
-0.008854916,
0.007902371,
0.00101913,
-0.004718862,
-0.013899649,
-0.018073304,
-0.010183467,
0.009080519,
-0.0013575344,
0.015566604,
-0.0038634506,
-0.033063367,
0.016819954,
-0.033063367,
-0.0025160997,
0.00042574725,
-0.024690991,
-0.00454966,
0.0054176045,
-0.025167264,
0.008804782,
0.0074260975,
0.017822634,
0.028676642,
0.00792117,
-0.009368789,
-0.012665099,
-0.00861678,
-0.021269346,
0.03286283,
0.010127066,
0.03419138,
0.0037475158,
0.0055930736,
0.029579055,
-0.039931722,
-0.014112718,
-0.000009118609,
-0.020053597,
-0.003766316,
-0.007827169,
-0.0065800864,
0.010214801,
0.0069999583,
-0.005257802,
-0.0093123885,
-0.010114533,
-0.011148546,
0.040683735,
-0.029378518,
0.024064315,
-0.0010316635,
0.014639125,
0.0052484022,
-0.005195135,
0.0022199957,
-0.009901463,
-0.025793938,
0.046925414,
0.021394681,
0.0011319316,
-0.022760833,
0.024264852,
0.009243455,
0.01881278,
0.018737579,
-0.030105462,
0.015428736,
0.015942609,
-0.01040907,
-0.040934402,
-0.6473301,
-0.028400905,
-0.0012282828,
0.017860234,
0.0022528963,
0.019827994,
0.0056432076,
0.02669635,
-0.008033972,
0.0146265915,
-0.0021808287,
0.024590723,
-0.024101917,
-0.021169078,
-0.0037224488,
-0.02386378,
-0.006905957,
-0.02895238,
0.0057090083,
-0.026596082,
-0.024177117,
0.019251453,
-0.0024659657,
0.013147639,
0.018236239,
0.0177349,
0.024302453,
-0.0077958354,
0.0016653885,
0.05740342,
-0.011956957,
0.03654768,
0.027899565,
0.020003462,
0.040433064,
-0.02157015,
-0.008585446,
0.0028184704,
0.0034592454,
0.044819787,
-0.024916593,
0.005279736,
0.009920264,
0.028375838,
-0.02143228,
0.026220078,
-0.009218387,
0.0011577818,
0.032837763,
-0.0055272724,
0.0066239536,
0.012552298,
-0.014789527,
-0.028075036,
0.02877691,
-0.018887982,
-0.008109173,
-0.0329631,
0.025179798,
0.025969407,
-0.010440404,
0.01802317,
0.010653473,
-0.00047901462,
-0.023713378,
0.025518201,
-0.016606884,
0.026295278,
0.0009956297,
-0.01368658,
0.00967586,
0.020141331,
-0.0065299524,
0.03948052,
0.042789362,
0.0010457637,
0.030682003,
0.037675694,
-0.013674046,
0.019151185,
0.0073696966,
0.0037349823,
-0.0038446505,
-0.0040953206,
0.012326695,
0.004803463,
-0.014137786,
0.0050509996,
-0.011706287,
-0.011204947,
0.04597287,
0.0013050504,
-0.0074448977,
-0.02382618,
-0.010252401,
0.03687355,
-0.02702222,
0.01744663,
0.017246094,
-0.013059905,
-0.0406336,
0.0040639867,
-0.014375922,
-0.0031271076,
0.027573695,
0.011092146,
-0.04514566,
-0.016556751,
0.039530654,
-0.048078496,
0.01170002,
0.0074072974,
-0.0053236033,
0.022058956,
0.033013232,
-0.011016944,
0.00072420115,
-0.025417933,
0.0056620077,
-0.016368749,
-0.006285549,
-0.004555926,
0.015616738,
0.024828859,
-0.011330282,
0.012383096,
-0.0010081632,
-0.013811914,
0.0011068645,
-0.013097505,
-0.008804782,
0.022472562,
0.02561847,
-0.024214718,
0.016669553,
-0.020379467,
0.021733085,
-0.007695568,
-0.0019395588,
-0.03948052,
-0.01898825,
-0.00071597606,
-0.020203998,
-0.008209441,
0.031484146,
0.0076329,
-0.0092058545,
-0.008322243,
0.015065264,
0.009237188,
-0.00082407746,
-0.022497628,
-0.0033433104,
0.01623088,
-0.0129721705,
-0.004283323,
0.011856689,
-0.0065424857,
0.00072302617,
0.010214801,
0.0023703978,
0.007213028,
-0.010590806,
-0.030180663,
-0.0021463614,
-0.043942444,
-0.011982024,
0.019940795,
-0.012896969,
-0.025254998,
-0.022096556,
-0.0055366727,
-0.0059722117,
0.010503071,
-0.011336548,
0.017634632,
-0.0015784374,
0.010089465,
-0.011856689,
-0.010089465,
0.0070250253,
0.016218346,
-0.0354698,
-0.005433271,
0.04156108,
0.00041713048,
0.0014922696,
0.0038979177,
0.0046405275,
0.024590723,
-0.02576887,
0.032737497,
0.00096351263,
0.004117254,
0.0004989899,
-0.0228235,
-0.0031882084,
-0.013987384,
-0.016281014,
0.008090373,
0.01956479,
-0.032361493,
0.015742073,
-0.031584416,
0.043591507,
-0.0016371881,
-0.0022372294,
-0.0020210266,
0.016381282,
0.0072568953,
0.0037882498,
-0.002218429,
0.0019505256,
-0.0120948255,
-0.022033889,
0.008077839,
-0.00863558,
-0.028150236,
-0.014914862,
-0.023450173,
-0.00811544,
-0.011468151,
0.029679323,
-0.016631952,
-0.013360709,
0.014275654,
0.0054865386,
0.00886745,
-0.012571098,
-0.006956091,
-0.02214669,
-0.0228611,
-0.004599794,
-0.0052264687,
0.007043826,
-0.015315934,
0.0025427334,
-0.028476106,
-0.0056087403,
0.017058091,
0.028325705,
0.0060192123,
0.022084024,
-0.003957452,
0.0023923314,
-0.012558565,
0.032236155,
0.013122573,
-0.014050051,
0.035494864,
0.008209441,
0.020680271,
0.010916676,
-0.006818223,
-0.008798515,
0.013235373,
-0.0073759635,
0.0040733865,
0.030255863,
0.015616738,
0.038803708,
0.019226385,
-0.017221026,
0.009976665,
0.0056620077,
0.027648896,
0.020404534,
0.014037518,
-0.006905957,
-0.0089489175,
-0.06176508,
-0.012815502,
0.007601566,
-0.020755472,
-0.0052922694,
0.011844155,
0.02340004,
-0.016093012,
0.0356202,
0.021056276,
0.0008585446,
-0.026094742,
0.011136013,
0.0038947845,
-0.008710781,
-0.016970355,
-0.014451123,
-0.003396578,
0.014112718,
0.013034837,
-0.0055022053,
0.011543351,
0.01064094,
-0.010666006,
-0.014501257,
-0.001928592,
0.021407215,
-0.01960239,
0.028676642,
0.022372294,
-0.0041391877,
0.013160173,
-0.0056024734,
-0.013172706,
0.028400905,
0.010459204,
0.007532632,
-0.00304564,
0.009707194,
-0.0010966811,
-0.016080478,
-0.0017562563,
-0.0096194595,
0.0064046173,
0.01819864,
0.014827128,
-0.0016058544,
0.014037518,
0.022597896,
-0.0037130488,
-0.015792208,
-0.026245145,
-0.008247041,
-0.012414429,
0.044569116,
0.0004653061,
-0.00058789935,
0.0065048854,
0.010358936,
0.025280066,
-0.00055617397,
-0.040909335,
0.0088987835,
0.018449308,
0.008698247,
-0.014350855,
0.020366933,
-0.009080519,
0.011925623,
0.006461018,
-0.0016168212,
-0.026044609,
-0.0044744588,
0.0050604,
-0.0178101,
-0.008980251,
0.018975716,
0.037049018,
0.053442836,
-0.022221891,
0.0038885176,
0.022673097,
-0.010979344,
-0.015491404,
0.0010128632,
0.023262171,
0.0017828901,
0.033589773,
-0.023487775,
-0.01222016,
0.0067743557,
0.014037518,
0.015967676,
0.006736755,
0.027247824,
0.024415253,
0.010358936,
0.014488723,
-0.008566646,
-0.014426056,
-0.012251494,
0.028250504,
-0.00015892084,
-0.015203132,
0.023600576,
-0.009343723,
-0.009838795,
-0.0072694286,
-0.020830674,
0.008077839,
0.021093877,
-0.01064094,
-0.00967586,
-0.0068495567,
-0.007463698,
-0.011280148,
0.02390138,
-0.008967717,
-0.022485094,
0.020128798,
-0.013298041,
-0.034667656,
0.000073046795,
-0.0043052565,
0.03429165,
-0.019690124,
-0.015829807,
0.006818223,
-0.0035877137,
-0.0053549367,
0.019965861,
-0.022384826,
0.026746484,
-0.002694702,
-0.029980127,
0.020442136,
0.003966852,
-0.006905957,
0.005047866,
0.0058719437,
-0.016293546,
-0.013210307,
-0.008159307,
-0.01148695,
-0.01168122,
-0.012063491,
0.008510245,
-0.015203132,
0.00019896928,
-0.03328897,
0.0065174187,
0.011242547,
-0.00036777984,
-0.010503071,
0.0013105338,
-0.031659614,
0.006385817,
-0.032311358,
-0.003496846,
0.00432719,
-0.009757328,
0.0059972787,
0.01623088,
-0.028852113,
0.02164535,
-0.01368658,
0.011392949,
-0.0030942073,
0.030431332,
-0.0030111729,
-0.008491444,
-0.0057027414,
0.011606019,
-0.013573778,
-0.013034837,
-0.02702222,
0.0108602755,
-0.020203998,
-0.013949783,
0.013648979,
0.018837847,
-0.030431332,
-0.01601781,
-0.0038540505,
0.004518326,
0.021344546,
-0.005856277,
-0.009506658,
-0.0304564,
0.005232735,
-0.0023233972,
-0.0143132545,
-0.009581859,
-0.02457819,
-0.0114242835,
-0.013661512,
0.0030425065,
-0.024929127,
0.022309626,
-0.038076766,
0.001137415,
-0.009763595,
-0.003866584,
0.012533498,
-0.0033245103,
-0.00454966,
-0.034391917,
-0.0037443824,
-0.012163759,
-0.021795753,
-0.019690124,
-0.0047407956,
0.034391917,
0.01702049,
0.028601442,
-0.0012980003,
0.010791342,
-0.009281055,
0.0027135022,
0.022986434,
0.0034185115,
0.015315934,
-0.027473427,
-0.0024408987,
0.0055022053,
0.019727726,
0.022698164,
0.0067492886,
0.017747432,
0.006316883,
-0.0010112966,
-0.014964996,
-0.019752793,
-0.02143228,
-0.002639868,
-0.014024984,
0.0029861059,
0.0017311893,
-0.0046655945,
-0.021532549,
0.026320346,
0.0051512676,
0.013699113,
-0.008503978,
0.026094742,
-0.03815197,
0.03579567,
0.0113741495,
-0.0051074005,
-0.023788579,
-0.011023211,
0.007006225,
-0.011386682,
0.030406265,
0.0065612863,
0.0042300555,
0.0018894247,
0.0038383836,
-0.0032023087,
0.015090331,
-0.018248772,
-0.018725045,
0.00229363,
-0.018612243,
0.0047407956,
-0.010221068,
-0.023500308,
-0.020768005,
-0.019038383,
0.0006678004,
-0.027172623,
0.014463657,
-0.01393725,
-0.0014797361,
-0.00535807,
0.0026680683,
0.0038979177,
-0.029654255,
0.051838547,
0.013912182,
0.0087421145,
-0.023700844,
0.023074169,
0.002088394,
-0.02336244,
0.029579055,
0.010954277,
-0.019439455,
-0.01569194,
0.007056359,
0.004007586,
-0.008729581,
-0.030180663,
0.020680271,
0.009525458,
-0.005499072,
0.0005303236,
0.002589734,
-0.038076766,
0.011938157,
-0.011267615,
-0.015679406,
-0.0011350649,
-0.021231744,
-0.01393725,
0.029428653,
-0.0018643577,
0.012871902,
0.008015172,
-0.009199588,
-0.009168253,
-0.028751845,
-0.020830674,
0.015403668,
0.011781488,
0.027849432,
-0.0028388372,
0.023575509,
-0.009356256,
-0.00031431663,
0.0027840033,
0.0032430426,
-0.027673963,
0.02494166,
0.0056839413,
0.001923892,
0.038227167,
-0.012871902,
0.010597073,
0.01856211,
0.00037600493,
-0.0016215213,
-0.045095526,
0.0044838586,
0.022284558,
0.0115809515,
-0.010503071,
0.019614924,
-0.031609483,
-0.006931024,
-0.024252318,
-0.009030385,
0.00686209,
-0.010101999,
0.0041297874,
-0.02472859,
-0.0077707684,
0.009644526,
-0.0013481344,
0.018649844,
0.00030942072,
-0.007482498,
-0.028526241,
0.031408947,
0.0202416,
0.023011502,
-0.002058627,
-0.0112174805,
-0.029102782,
-0.03343937,
0.030932672,
0.008015172,
-0.04110987,
-0.01863731,
-0.0021620283,
-0.0032273757,
0.003000206,
-0.008033972,
-0.0006486085,
0.0017202225,
0.023776045,
-0.0015369202,
-0.008378644,
0.040132258,
-0.020968542,
0.0006662337,
0.0001173057,
0.0038101834,
-0.018524509,
0.013260441,
0.002719769,
-0.01680742,
-0.0115809515,
-0.001119398,
-0.021206679,
0.03654768,
-0.006987425,
0.008767182,
-0.019627457,
0.013736714,
-0.021231744,
0.015930075,
0.0019599258,
0.0008373943,
-0.027247824,
-0.00060787465,
0.0015800041,
0.009519191,
-0.011330282,
-0.007056359,
-0.021194145,
-0.008315976,
-0.014212986,
-0.007488765,
-0.012834301,
0.03739996,
0.01881278,
0.004653061,
-0.026545947,
0.003960585,
-0.041185074,
-0.008679447,
0.009469057,
0.012213893,
0.0075263656,
0.022936301,
-0.0054050707,
0.018161038,
-0.0055930736,
0.011092146,
-0.036246877,
-0.017885301,
0.018098371,
-0.0050384663,
0.052440155,
0.0071252934,
-0.022171758,
0.004524593,
0.013498577,
-0.004762729,
-0.006116347,
0.030356131,
0.008610513,
0.029102782,
-0.0063137496,
0.032160956,
0.0018142238,
-0.016644485,
0.015152999,
-0.009011585,
-0.0060630795,
-0.0050760666,
-0.008240775,
0.0002083694,
-0.016381282,
-0.0034999792,
-0.0023265304,
0.009519191,
-0.0028090703,
-0.012859369,
0.0033840444,
-0.01960239,
-0.0054677385,
0.004107854,
0.01598021,
-0.011862956,
0.0013215006,
0.0013661513,
0.02235976,
0.0107537415,
0.0124081625,
-0.001066914,
0.0028795712,
0.013736714,
-0.019426921,
-0.00609128,
0.029553987,
-0.030581735,
0.013147639,
-0.002393898,
-0.016418882,
-0.033815376,
0.028125169,
0.0035375797,
0.0013692846,
0.011499484,
0.017634632,
-0.009863863,
0.0066051534,
0.0005350237,
-0.0004461142,
0.0005655741,
-0.007958771,
0.010653473,
-0.008159307,
0.0127215,
-0.009970398,
-0.020279199,
-0.03243669,
-0.008503978,
0.18639818,
-0.003841517,
0.0043209232,
0.03604634,
0.012477097,
0.023149371,
0.031509213,
0.007438631,
-0.007538899,
0.00033918777,
0.0036441144,
0.0041548545,
0.0003605339,
0.0050604,
0.0035469797,
-0.0014178519,
-0.026245145,
-0.020166397,
0.010377736,
-0.020329334,
-0.008892517,
-0.0024706658,
-0.00686209,
-0.009061719,
0.031835083,
0.008178107,
0.0060724798,
0.007764502,
0.012376829,
0.022622963,
-0.0023797979,
-0.0013763347,
-0.0039010511,
0.029528921,
-0.0000564497,
-0.009857596,
-0.00087812816,
-0.027473427,
0.022698164,
0.008259575,
-0.02264803,
-0.015115398,
-0.035720468,
-0.010315069,
0.016393814,
0.012076025,
-0.007488765,
-0.01834904,
-0.021795753,
0.005818676,
-0.017509297,
-0.033965778,
0.030707069,
0.035168994,
0.0048567303,
0.0013301175,
0.02451552,
-0.009243455,
-0.0120948255,
0.01551647,
0.013272974,
0.013059905,
-0.00836611,
0.03536953,
-0.031885218,
0.009519191,
-0.03995679,
-0.0038947845,
-0.016970355,
-0.0041485876,
0.0054614716,
-0.0070500923,
-0.003941785,
0.011399216,
0.0048661307,
-0.0023860647,
0.024741124,
0.0064484845,
-0.0009846629,
0.0006819006,
-0.031484146,
-0.003781983,
0.005470872,
0.00048802307,
-0.019339187,
-0.031985488,
0.012050958,
-0.003857184,
-0.019589856,
0.010064399,
0.012270294,
-0.0034435785,
-0.0007488765,
0.007958771,
-0.010227334,
-0.028375838,
-0.01351111,
-0.0104968045,
0.0009071119,
-0.029102782,
-0.003910451,
0.0584061,
-0.0039261184,
0.037174355,
-0.011073345,
-0.025493134,
-0.02390138,
-0.00460606,
0.0024878993,
-0.00028513707,
0.021733085,
-0.04361657,
0.0024032982,
-0.011048278,
-0.021896021,
0.00909932,
0.008510245,
-0.02490406,
-0.019439455,
-0.011693753,
0.0060693463,
-0.023312306,
0.025468068,
0.014939929,
-0.024477921,
0.003822717,
-0.018687446,
-0.0037757163,
-0.007733168,
-0.039154645,
0.012596165,
-0.043265633,
0.010528138,
0.0034749121,
0.010170934,
0.00811544,
0.011443083,
-0.0028607708,
0.034492187,
0.01659435,
-0.006786889,
-0.025894206,
0.007601566,
-0.009832529,
0.0029814057,
-0.031333745,
0.022033889,
0.002418965,
0.00020327767,
0.0072568953,
-0.02769903,
-0.009832529,
0.0073759635,
-0.009957864,
0.024665924,
-0.004624861,
-0.0022058955,
-0.032637227,
-0.005445805,
0.02962919,
-0.0056212735,
0.0279497,
0.028476106,
-0.019915728,
-0.01089161,
0.014877262,
-0.15431242,
0.017058091,
0.025969407,
-0.04228802,
0.025280066,
0.0028435374,
0.018336507,
-0.009086786,
0.01601781,
0.018938115,
0.030406265,
0.00087029475,
-0.028325705,
0.023750978,
0.006160214,
0.004853597,
0.00024851575,
0.023287239,
0.01938932,
0.010101999,
0.012884435,
-0.011493217,
0.0014037518,
-0.0143633885,
-0.0053236033,
0.019376788,
0.008717048,
0.010791342,
-0.0111172125,
0.009989197,
0.0060442793,
0.025417933,
0.026571015,
-0.010145866,
0.0072318283,
-0.021319479,
-0.0049507315,
0.0043052565,
-0.010014265,
0.0035689136,
0.037324756,
0.01730876,
0.0127215,
0.0054489383,
-0.013034837,
0.035545,
0.0117877545,
-0.008378644,
0.020442136,
-0.0030440732,
0.03830237,
0.0032117087,
0.028425973,
0.01995333,
-0.020203998,
-0.007513832,
-0.012207626,
0.017471695,
0.021996288,
0.0032712428,
-0.0043898574,
-0.03376524,
0.0104968045,
0.0019912594,
0.014175386,
-0.01584234,
-0.013648979,
-0.0074762315,
-0.011317749,
0.00581241,
-0.035344463,
-0.00844131,
-0.0018283239,
0.0031130074,
0.0306068,
-0.0035657801,
-0.0012314161,
0.0060129454,
-0.026997155,
-0.008052772,
-0.00031921253,
-0.0035532466,
-0.038101833,
-0.01744663,
-0.021745618,
0.021206679,
0.019765327,
0.0013841682,
0.007808369,
-0.008554112,
0.0074950317,
-0.033690043,
0.007996372,
-0.025969407,
-0.0044149244,
0.009707194,
0.006811956,
0.019000782,
0.0080715725,
0.0052358685,
0.00020464852,
-0.024565656,
-0.017697299,
-0.00015226241,
0.006160214,
-0.012307894,
-0.012132426,
-0.014137786,
0.023086702,
-0.016281014,
-0.011649886,
0.0025129663,
0.015917541,
0.01222016,
-0.0075764996,
0.036522612,
-0.015566604,
-0.012276561,
0.022372294,
-0.0020429601,
0.040006924,
0.012621232,
-0.0073383627,
0.017684765,
-0.0023014636,
-0.006805689,
-0.11841649,
-0.028827045,
0.0115308175,
0.012101092,
0.010302535,
0.023199504,
0.00069521746,
0.00840371,
-0.013185239,
0.013059905,
-0.021620283,
0.002834137,
-0.0072192946,
-0.0009862296,
0.020417068,
-0.015529004,
0.0017045557,
-0.018073304,
-0.02451552,
0.03143401,
-0.0029782725,
-0.0114744175,
-0.0065800864,
-0.015992744,
-0.0064860852,
0.007896104,
-0.008729581,
0.022836033,
0.006103813,
0.016782353,
0.009105586,
0.013573778,
0.010879076,
-0.015704473,
-0.011405483,
-0.0010676973,
-0.014388455,
-0.023562975,
0.017170891,
-0.005793609,
-0.004618594,
0.021770686,
0.01744663,
0.0018173571,
0.0047971965,
0.009324922,
-0.029328385,
-0.02407685,
0.010866542,
-0.014400989,
-0.004562193,
0.0037193154,
-0.04396751,
-0.01601781,
0.0012110493,
-0.016832488,
0.006335683,
0.008817316,
-0.0013841682,
0.0019928261,
0.01659435,
0.021444814,
-0.024828859,
0.011367883,
0.017007956,
-0.030707069,
0.0063074827,
-0.029353451,
0.0013912183,
-0.011173613,
0.007589033,
0.01064094,
-0.0013442177,
-0.024314985,
-0.018123439,
0.016356215,
0.0012345496,
-0.011211214,
-0.0033433104,
-0.019903194,
-0.018173572,
-0.007068893,
0.03622181,
-0.008591712,
0.016343681,
-0.00022521129,
0.012320428,
0.007965038,
0.0056212735,
-0.024678458,
-0.0050666663,
0.028075036,
0.032737497,
-0.0066803545,
0.00788357,
0.025844073,
0.013661512,
-0.01702049,
0.020580003,
0.0005267986,
-0.010941744,
-0.022798432,
-0.041987218,
0.0023139971,
0.014689259,
-0.002970439,
-0.0075764996,
-0.015140465,
-0.011192413,
-0.0035375797,
-0.0014272521,
-0.00010770975,
0.0012368995,
0.027673963,
-0.008842383,
0.0020930942,
-0.031058008,
-0.034391917,
0.011023211,
0.002619501,
0.026771551,
0.03504366,
-0.004418058,
0.016707152,
0.016744753,
0.025844073,
-0.014275654,
0.0026586682,
-0.005818676,
0.013999917,
-0.010822675,
-0.03419138,
0.020329334,
-0.036597814,
-0.016707152,
0.014137786,
-0.012314161,
-0.015278334,
-0.004753329,
0.0203544,
0.008491444,
0.016657019,
-0.00029140382,
-0.027473427,
0.004436858,
0.0006012162,
0.0019207585,
-0.014802061,
-0.028250504,
0.008146773,
-0.005981612,
-0.033263903,
0.013135105,
0.013147639,
-0.0036315809,
-0.025643537,
-0.013072439,
-0.014413523,
-0.005981612,
-0.0028921047,
-0.01401245,
-0.017434096,
0.007012492,
0.0009376623,
0.00084209436,
-0.019614924,
0.015503936,
-0.017546898,
-0.017283693,
0.00304564,
-0.0039073178,
-0.010196,
-0.032988165,
0.014990063,
0.007695568,
0.009519191,
0.007670501,
-0.0020617603,
-0.005574273,
0.014451123,
0.007018759,
0.025743805,
-0.000316275,
0.0060693463,
-0.026245145,
0.03454232,
0.041084807,
0.002909338,
0.00611008,
0.03855304,
0.026019542,
0.006367017,
-0.018649844,
0.023600576,
-0.0066176867,
0.0020413934,
0.017785033,
0.020128798,
0.0009862296,
0.01397485,
0.008497711,
0.000683859,
-0.0034028445,
-0.013887116,
0.0066490206,
-0.018587178,
-0.02576887,
0.008221975,
0.0005428571,
-0.006962358,
-0.0066552875,
0.009475324,
0.0009086786,
0.006166481,
0.0177725,
0.004888064,
-0.0053988043,
0.00019466088,
-0.0018016903,
0.030180663,
-0.017409028,
0.0134359095,
-0.00012631416,
0.0382021,
0.014451123,
-0.009625726,
0.016255947,
0.011537084,
0.0075764996,
0.0012690166,
0.017960502,
-0.007927437,
0.008829849,
-0.0074448977,
-0.027774232,
-0.020617604,
-0.023349905,
-0.029829724,
0.0040201196,
0.00094001234,
-0.0057340753,
0.06432191,
-0.00047274787,
-0.012596165,
-0.01881278,
0.0010990311,
0.019665059,
0.008566646,
0.010264935,
-0.034492187,
0.004001319,
0.01952719,
-0.030932672,
0.0037287155,
-0.045647,
-0.017045557,
0.012947103,
0.01931412,
-0.004928798,
0.0067492886,
-0.009751061,
-0.0013246341,
-0.030631868,
0.022234425,
0.020341868,
-0.010816408,
-0.012909503,
0.046173405,
0.020592537,
-0.0014985363,
-0.040157326,
-0.01981546,
0.009249722,
-0.04727635,
0.0055962065,
0.024014182,
-0.025430467,
-0.0117877545,
-0.020880807,
0.022510162,
-0.0066991546,
-0.015879942,
0.020617604,
-0.025543269,
0.0059690783,
-0.030932672,
-0.025718737,
-0.025580868,
-0.024528055,
0.0017844568
] |
Cells of the immune system have evolved various molecular mechanisms to sense their environment and react to alterations of self. NK cells are lymphocytes with effector and regulatory functions, which are remarkably adaptable to changes in self. In a study published in this issue of the JCI, Tarek and colleagues report the clinical benefits of manipulating NK cell adaptation to self in an innovative mAb-based therapy against neuroblastoma (NB). This novel therapeutic strategy should stimulate further research on NK cell therapies. | [
-0.023928126,
0.0060086926,
0.003989132,
-0.01481011,
-0.0014980073,
0.0096379025,
-0.00909802,
0.009011372,
-0.02311497,
0.0062819663,
0.01111758,
-0.013317103,
0.0047156406,
0.0067418665,
-0.014970075,
-0.0019329127,
0.036338758,
-0.007984929,
-0.026274282,
-0.0023294932,
-0.030606674,
0.019942326,
0.0040091276,
-0.021328691,
-0.0102577675,
-0.0035358972,
0.0013505395,
-0.041484307,
0.0040157926,
-0.014663476,
0.012690572,
-0.009217994,
-0.0054888055,
-0.0024128084,
0.0051555447,
-0.020275587,
0.01387698,
-0.038364984,
0.033432726,
0.0063719465,
0.0057354188,
0.004968919,
0.00008701232,
-0.008411503,
-0.0037091929,
0.0020378898,
0.00087480963,
-0.008491485,
-0.0034925733,
0.023821482,
0.022301814,
-0.008204881,
-0.018862562,
0.019035857,
-0.039298113,
-0.025487786,
-0.0065019187,
0.007824964,
0.00041803403,
-0.0542282,
-0.020422222,
-0.0051322165,
-0.015649928,
0.014196911,
0.016169814,
0.0075050336,
0.0089247245,
0.02403477,
-0.0022278486,
0.011630802,
0.02092878,
0.026687525,
-0.017382884,
0.007698325,
0.015463302,
-0.009491268,
-0.012837207,
0.015196693,
-0.016489744,
-0.0061553274,
0.009904511,
-0.019035857,
-0.00447236,
0.035272326,
0.017089615,
-0.0011905743,
-0.0021545312,
-0.0036725341,
0.013057158,
0.0027394039,
-0.0018096062,
0.017369553,
0.029780187,
0.015263345,
-0.0134237455,
0.026820831,
0.00493226,
0.014250233,
0.0020512203,
-0.028180534,
-0.007864955,
0.013063824,
-0.014530172,
-0.019995648,
-0.028820395,
0.0023378246,
-0.012857202,
-0.0026977463,
0.032153003,
0.014690137,
-0.03241961,
0.015863216,
-0.01417025,
-0.032766204,
0.04287067,
0.004142432,
0.0030110115,
-0.018102728,
-0.027354049,
-0.00076191756,
0.01664971,
0.022008544,
0.015263345,
-0.032446273,
0.024634639,
0.014916754,
0.010664346,
-0.034739107,
-0.03505904,
0.004349054,
0.0122240065,
0.014556833,
0.0041457647,
0.02991349,
-0.0008044083,
-0.000100551035,
0.009051364,
0.008918059,
0.0045090187,
0.007824964,
0.028553786,
0.043990426,
-0.011624137,
0.0027693973,
-0.0038225015,
0.005585451,
0.026874153,
0.017769467,
0.0055321297,
-0.012870532,
-0.024527997,
-0.024634639,
0.012237337,
-0.010264433,
0.0070051425,
0.0004861442,
-0.0010222775,
0.026994126,
-0.033139456,
-0.024927909,
-0.00030326733,
-0.013850319,
0.019942326,
-0.010364411,
0.01943577,
0.02586104,
-0.0001478845,
0.009791203,
-0.0075450246,
0.001677135,
0.020728823,
0.036205456,
0.006435266,
0.0039558057,
-0.015196693,
0.0068651726,
0.021688614,
0.009537924,
-0.006515249,
-0.0022678399,
0.0009156341,
0.03668535,
0.01972904,
-0.003425921,
-0.007438381,
0.000937296,
0.019995648,
-0.021515317,
-0.0033192777,
-0.012077372,
0.0075716856,
0.011264215,
-0.018982535,
-0.020182274,
-0.6279167,
-0.017689483,
0.03417923,
0.007611677,
-0.0041357665,
0.030926604,
0.017876111,
-0.02344823,
-0.015836554,
0.008338186,
-0.014983406,
-0.0059253774,
0.0146768065,
-0.037351873,
-0.033059474,
-0.048389472,
-0.012017385,
-0.026100988,
0.0363121,
-0.026860822,
-0.0066818795,
-0.012297324,
0.0070384685,
0.0052421927,
-0.012463954,
0.007178438,
-0.0022228495,
0.01446352,
-0.008231542,
0.05572121,
-0.020742154,
0.010404402,
0.011237554,
0.012350646,
0.050415695,
-0.004199086,
-0.0030010135,
0.01539665,
0.010511046,
0.020408893,
-0.00894472,
-0.0065085837,
0.009644568,
0.0009847857,
-0.012390637,
0.011784103,
-0.004285734,
0.0027410702,
0.009651233,
0.005282184,
0.021728605,
0.01664971,
-0.027673978,
0.012517276,
0.01510338,
0.01064435,
0.008404838,
0.0024527996,
0.007738316,
-0.0010497716,
0.0017179595,
0.012730563,
-0.028473804,
-0.024368031,
-0.008431499,
0.02338158,
-0.023834813,
0.008391507,
-0.014890093,
-0.0067185382,
0.02004897,
0.018915884,
-0.016849667,
0.020888789,
0.022635074,
0.030846622,
0.0019462431,
-0.006268636,
0.0006427768,
-0.0051555447,
-0.016076501,
-0.018422658,
-0.017102946,
0.017196259,
0.019155832,
0.0042057517,
-0.00816489,
0.016409762,
0.0147434585,
0.0073583988,
0.004938925,
-0.006791855,
0.00013767838,
-0.048202842,
-0.013983624,
0.026567552,
-0.013943632,
0.0000015914505,
0.014663476,
-0.022008544,
-0.0128305415,
-0.0015463302,
0.016529737,
-0.015170032,
0.0048356145,
-0.0102844285,
-0.032179665,
0.0028043897,
0.060733452,
-0.02467463,
0.004875606,
-0.007738316,
-0.006871838,
0.014876762,
0.025407804,
-0.016396431,
0.016156483,
0.02126204,
-0.00034971556,
-0.025047883,
0.020795476,
0.0025077877,
0.0052455254,
-0.007205099,
0.005875388,
-0.008084907,
-0.0041624275,
-0.009038033,
-0.0012513944,
-0.026914144,
-0.004232412,
0.0058553927,
0.009811198,
-0.0134370765,
0.019595737,
0.007491703,
0.015649928,
0.0050422363,
0.012477285,
-0.021102075,
-0.030606674,
-0.025541108,
0.007031803,
-0.0024128084,
-0.0034759103,
0.017369553,
-0.0025927692,
0.00005670641,
0.0022761715,
0.0027327386,
0.011164238,
0.01141085,
-0.008491485,
0.016836336,
0.030953264,
-0.017036293,
-0.026754178,
-0.014436859,
0.008631455,
-0.017516188,
-0.015329997,
0.015436641,
0.00047323035,
0.006905164,
-0.012310655,
0.003512569,
-0.011724115,
0.018995866,
0.0206755,
-0.071131185,
0.0059153796,
-0.01848931,
-0.028687092,
-0.001205571,
0.012044046,
-0.012204011,
-0.018875893,
-0.019169163,
-0.0024044767,
-0.008491485,
0.0031393168,
-0.023848144,
-0.0061286665,
-0.021835249,
0.026100988,
0.009071359,
0.035165682,
0.008524812,
-0.000080763675,
0.02927363,
-0.011390855,
0.014370207,
-0.014916754,
0.0101777855,
0.001550496,
-0.039937977,
0.008378177,
0.0041524298,
0.014156919,
0.03729855,
-0.009604577,
-0.027047448,
0.022048535,
-0.011517494,
-0.001293885,
-0.030180098,
0.010091137,
-0.02158197,
0.007618342,
-0.0014680139,
0.011197563,
0.01942244,
-0.010484385,
-0.0055487924,
0.008098238,
0.0115108285,
-0.0014638482,
0.010197781,
-0.0018612617,
-0.031326517,
0.00755169,
-0.005725421,
0.016423093,
-0.017102946,
-0.0009856189,
0.020528866,
-0.0021628626,
0.01664971,
0.0025461125,
-0.004738969,
-0.0074250507,
-0.010591028,
0.006991812,
-0.0007748314,
0.022861691,
0.024701292,
0.025487786,
-0.0050755623,
0.01971571,
-0.0076849945,
-0.011850755,
0.0011930737,
-0.013257115,
-0.0008581466,
0.015516624,
-0.016889658,
0.029300291,
0.016609719,
-0.015663259,
0.0062786336,
-0.01664971,
0.004432369,
-0.017142937,
0.0057720775,
0.0075650206,
-0.01908918,
0.011457507,
0.01032442,
0.041484307,
0.019409109,
0.028393822,
-0.004235745,
-0.009424616,
-0.017196259,
0.013970293,
-0.00056404393,
0.026087657,
-0.015783232,
-0.0020262257,
0.0004324059,
-0.03636542,
-0.0096379025,
0.020835467,
-0.024488004,
0.029033681,
0.024288049,
0.02063551,
0.005875388,
0.014516841,
0.025474457,
-0.011530824,
-0.008158225,
0.029326951,
0.012610589,
-0.0020478878,
-0.020355571,
-0.040151265,
-0.008678111,
-0.014356876,
0.017942762,
0.0015596607,
0.008751429,
-0.014610155,
0.005458812,
-0.0057020923,
-0.008884734,
0.016249798,
-0.018875893,
0.03257958,
-0.014570163,
0.00023786491,
-0.012303989,
-0.00485561,
0.007918277,
0.0134504065,
0.017062955,
0.007118451,
-0.02092878,
-0.00787162,
-0.017182928,
0.0045290147,
-0.017822789,
0.021422004,
-0.025647752,
0.0037125254,
0.015863216,
0.0035825537,
0.018382667,
0.0058320644,
0.009824528,
-0.013743676,
-0.038471628,
0.0042390777,
-0.005195536,
0.038418308,
-0.017222919,
0.0035758885,
0.023168292,
0.003112656,
-0.0055321297,
-0.0073583988,
-0.012617255,
0.022061866,
-0.021022093,
-0.02924697,
0.015236684,
-0.005195536,
0.0031943049,
-0.008184886,
0.024261387,
-0.005418821,
-0.006998477,
-0.008098238,
0.0058387294,
0.017009633,
0.009657898,
0.05260189,
0.02863377,
0.0035258995,
0.006528579,
0.01018445,
0.015223354,
-0.0109309545,
-0.022555092,
0.004505686,
0.027780622,
0.010151125,
-0.0012947182,
-0.025967682,
-0.038658254,
0.014156919,
0.022541761,
-0.0021028758,
-0.0071651074,
0.041670933,
0.0008281531,
0.0068318467,
-0.011517494,
0.006328623,
0.010671011,
0.026714187,
0.019742372,
-0.014436859,
-0.0047423015,
0.019409109,
-0.035645578,
-0.028713752,
0.0016912987,
0.009451277,
0.033512708,
-0.004828949,
0.00454901,
0.01759617,
-0.008551473,
0.0011464172,
-0.014863432,
0.019249145,
-0.0014396867,
-0.011504163,
-0.001939578,
-0.006428601,
-0.004845612,
-0.034045924,
-0.014410198,
0.016729692,
-0.021501988,
-0.0018329344,
0.020728823,
0.026007675,
0.008438163,
0.03265956,
-0.0040457863,
-0.0046223276,
0.02863377,
-0.0009464607,
-0.007578351,
-0.014570163,
-0.043910444,
0.021115405,
-0.00941795,
0.010451059,
-0.021088744,
-0.0128438715,
-0.0073783942,
-0.017342893,
-0.016663041,
-0.008851407,
0.021155396,
-0.02246178,
0.01358371,
0.019449102,
0.009064694,
-0.015849885,
-0.012017385,
-0.03052669,
0.0018196041,
0.0005852893,
-0.02070216,
-0.017489528,
-0.03148648,
-0.0006202817,
0.032739542,
-0.010584364,
-0.011484168,
0.026047666,
-0.018902553,
0.007145112,
-0.031033248,
0.006361949,
0.02154198,
0.0051488797,
0.011130911,
-0.0031643114,
-0.018089397,
-0.016249798,
-0.019369118,
0.015170032,
0.0127905505,
-0.0018812573,
-0.01539665,
0.0030443375,
0.0041890885,
-0.016902989,
-0.014943415,
-0.011637468,
0.011984059,
-0.017689483,
-0.016569728,
-0.020875458,
-0.022635074,
-0.012563933,
0.017809458,
0.019115841,
-0.030553352,
-0.00048572765,
0.017662823,
0.008131564,
-0.0015538286,
0.020862127,
-0.030899942,
-0.016369771,
0.02802057,
-0.006811851,
0.010597694,
-0.02618097,
0.009951168,
-0.024861258,
-0.006515249,
-0.008858073,
-0.029780187,
-0.016103163,
0.0077849724,
0.0425774,
0.047882915,
0.017689483,
-0.014103598,
0.02712743,
0.0010780988,
-0.005578786,
0.0020578855,
0.008711438,
0.027593995,
-0.016236467,
0.0089780465,
-0.001594653,
-0.026994126,
-0.006208649,
-0.019809023,
-0.015903207,
0.02278171,
-0.006361949,
-0.012057376,
-0.004025791,
-0.025741065,
-0.018915884,
0.022875022,
-0.020862127,
0.026874153,
-0.026900813,
-0.0048589427,
0.013063824,
0.013397085,
0.0028560453,
0.0024894583,
0.015543285,
-0.010830976,
-0.012244002,
-0.008198216,
0.005382162,
-0.018142719,
-0.0016937981,
-0.002324494,
-0.02191523,
0.012983841,
0.03113989,
-0.0068318467,
0.016303118,
-0.003172643,
-0.0033692669,
-0.0017962758,
-0.028500466,
-0.026980795,
-0.010970946,
-0.024821265,
-0.016663041,
0.0052155317,
-0.028447144,
-0.005418821,
0.0054254862,
0.026100988,
-0.0068085184,
0.004935593,
-0.0134237455,
-0.018169379,
0.03257958,
-0.0016846334,
0.006145329,
-0.04215083,
0.010517712,
0.008431499,
-0.005585451,
-0.018342676,
-0.024861258,
-0.005585451,
0.007971599,
0.03423255,
0.017489528,
-0.008338186,
-0.0025127865,
-0.0066985423,
0.0057020923,
0.003895819,
-0.02746069,
0.020488875,
-0.020288918,
0.00632529,
-0.02432804,
-0.0249679,
-0.018942544,
0.028820395,
0.00709179,
0.0038924862,
0.0067318683,
0.0109042935,
-0.023061648,
0.021995213,
-0.006998477,
0.006145329,
0.0041790907,
-0.026021004,
0.013037163,
-0.020262258,
-0.022661736,
-0.013717015,
-0.014556833,
0.00755169,
0.012530606,
0.0002743153,
0.039244793,
-0.013770337,
0.011610807,
0.0017879442,
-0.026394257,
0.041164376,
-0.032739542,
-0.0074783727,
0.01723625,
-0.0042557404,
0.01910251,
-0.0028177202,
-0.010551037,
0.01417025,
-0.026460908,
-0.007944938,
0.020355571,
0.018675936,
-0.022608414,
-0.002614431,
-0.034632463,
-0.03111323,
-0.03113989,
-0.018662605,
-0.0060086926,
-0.030686656,
-0.0147167975,
0.010830976,
0.0005523798,
0.010497715,
0.007958268,
-0.010144459,
-0.0025244507,
0.0499358,
-0.012317319,
-0.005678764,
0.008238208,
0.004175758,
-0.016849667,
0.007964933,
-0.007824964,
-0.016583059,
-0.007085125,
-0.016769685,
-0.036925297,
-0.01265058,
-0.014996736,
0.025981013,
0.026074326,
-0.022728387,
0.0034292538,
0.027593995,
0.015383319,
-0.005135549,
-0.010311089,
0.011984059,
-0.027407369,
-0.012090703,
0.024741283,
-0.03177975,
-0.0067651947,
0.014156919,
-0.026740847,
0.0008964716,
-0.02187524,
-0.029406935,
-0.030340064,
0.00032388786,
0.0015863215,
0.0057620793,
-0.00922466,
-0.0021628626,
-0.024701292,
0.008591464,
0.024461344,
-0.00012434793,
-0.017449535,
0.015050058,
0.020622179,
0.024461344,
-0.020408893,
0.010817646,
-0.01606317,
-0.035005715,
-0.01571658,
0.002142867,
-0.025341153,
0.04436368,
0.01447685,
0.014516841,
-0.029780187,
0.0048122862,
-0.061799884,
0.0004619828,
0.009811198,
0.023208283,
-0.0003924146,
0.033272758,
-0.0052455254,
-0.015569945,
0.011157572,
0.0075450246,
-0.00006951612,
-0.04097775,
0.021861909,
-0.004965586,
0.032606237,
0.0068251817,
-0.007498368,
0.005288849,
0.031273194,
-0.016103163,
0.004958921,
0.020502206,
-0.030633334,
0.012124028,
0.004732304,
0.025754396,
-0.00027494016,
0.0307933,
0.019355789,
-0.010197781,
-0.0040124604,
0.018116059,
-0.01879591,
0.004652321,
0.0060986727,
0.003759182,
0.009984494,
0.020355571,
-0.022035206,
-0.035858862,
-0.001742954,
-0.0025377811,
0.025367813,
0.012710568,
-0.010437729,
0.014236902,
-0.019275805,
-0.0062719686,
-0.011710785,
-0.005902049,
-0.0040624496,
0.012617255,
-0.008664781,
0.004259073,
-0.0067118728,
0.014036945,
-0.0006040352,
-0.018595953,
-0.005178873,
-0.002317829,
-0.002602767,
-0.026340935,
-0.013197129,
0.008524812,
-0.024208065,
0.005678764,
-0.001984568,
-0.009151342,
-0.017329562,
-0.0047489665,
0.019142501,
-0.0036958624,
0.004235745,
0.0053788293,
0.006225312,
-0.0064485967,
-0.0003595051,
-0.008284864,
-0.023288265,
-0.018236032,
0.19110508,
-0.020608848,
0.0038858212,
-0.0029726864,
-0.014650146,
-0.003909149,
-0.01032442,
0.0031709766,
-0.01064435,
-0.006265303,
0.037511837,
-0.0025711071,
-0.0022711724,
-0.000099457524,
0.019662388,
-0.018356005,
-0.01169079,
-0.0062219794,
-0.0001649641,
-0.006548575,
0.0042057517,
0.008004925,
-0.0033659341,
0.006295297,
0.04497688,
0.015050058,
-0.021048753,
0.020168945,
0.007911611,
-0.004905599,
-0.027807282,
0.020475544,
0.014610155,
-0.003057668,
0.021995213,
0.011057594,
-0.0030076788,
-0.005288849,
0.008124899,
-0.008131564,
-0.011157572,
0.0025777724,
-0.020262258,
0.019169163,
0.012863867,
0.045723382,
-0.004065782,
-0.0052155317,
-0.0016838002,
-0.015250015,
-0.03023342,
-0.0072250944,
0.00941795,
0.008591464,
0.015889876,
0.0019229149,
0.009371294,
0.01078432,
-0.00447236,
0.025994344,
-0.022675065,
-0.01093762,
-0.028713752,
0.04646989,
0.011924072,
0.031913057,
-0.0035592255,
-0.015036728,
0.02743403,
-0.010397738,
-0.010884298,
-0.00546881,
-0.006028688,
-0.0012197345,
-0.011197563,
-0.008191551,
0.021062084,
-0.005588784,
0.0013338764,
-0.0011689123,
0.022368466,
0.010697672,
-0.039004847,
0.008211547,
-0.0019629062,
-0.031913057,
-0.009984494,
0.010117798,
-0.021608632,
-0.015143371,
0.010084473,
-0.0003924146,
-0.030766638,
0.01912917,
0.010704338,
0.012263998,
0.021928562,
0.0017054622,
-0.01446352,
-0.023034988,
-0.031886395,
0.077636436,
0.005195536,
0.011437511,
-0.016049841,
0.011477502,
-0.0020845465,
-0.0036225452,
-0.0054321513,
-0.019409109,
0.027487352,
-0.03607215,
0.018036075,
-0.004712308,
-0.0013013835,
0.0277273,
-0.004302397,
-0.018435989,
0.030260082,
-0.01572991,
0.00010138419,
-0.0047756275,
-0.003895819,
0.019155832,
-0.017156268,
0.030393386,
-0.03212634,
0.0095579205,
0.02032891,
-0.016596388,
-0.019489093,
-0.014250233,
-0.011477502,
0.03199304,
0.018089397,
-0.015943198,
0.013523724,
-0.008524812,
-0.015156702,
0.0037858428,
-0.0030376723,
-0.0057887402,
0.008151559,
0.031673107,
0.018915884,
-0.0033526039,
0.031939715,
0.042977314,
-0.0077849724,
-0.0026927474,
-0.00499558,
-0.026300944,
-0.009504599,
-0.007458377,
0.014956745,
-0.007298412,
-0.026074326,
0.016516406,
0.012263998,
-0.009171338,
-0.032686222,
0.028767074,
0.018435989,
-0.020542197,
-0.012350646,
-0.01293052,
-0.16668373,
0.0057754098,
0.02927363,
-0.029166987,
0.029646883,
0.017009633,
-0.016556397,
0.00038449967,
-0.030180098,
0.027020786,
0.028500466,
-0.002839382,
-0.04908265,
-0.037698463,
0.003469245,
-0.00017766967,
-0.0015213356,
0.034579143,
0.0108643025,
0.022608414,
0.02223516,
-0.016303118,
0.0034459168,
0.01968905,
-0.0023594867,
0.021981884,
-0.00523886,
-0.026967466,
-0.013956963,
-0.0083448505,
0.003969136,
-0.007951603,
0.007818298,
-0.01171745,
0.014610155,
0.017316232,
-0.014116928,
-0.0070118075,
-0.0011747443,
0.023581535,
0.03425921,
0.0073450683,
-0.0032676223,
0.0063652815,
-0.0071251164,
0.033725996,
0.008771424,
-0.0057720775,
-0.006191986,
-0.018715927,
0.027074108,
-0.0147567885,
0.009677894,
0.0018995866,
0.036285438,
0.018022744,
0.014876762,
-0.0005786241,
0.018875893,
0.0035258995,
-0.0030276745,
-0.02191523,
0.011517494,
0.0052188644,
-0.010497715,
-0.009424616,
0.0032459602,
0.037218567,
-0.017036293,
0.0016196476,
-0.031513143,
0.013943632,
0.028393822,
-0.00739839,
0.030659994,
0.0073050773,
0.0024261386,
-0.006625225,
-0.009284646,
0.014063606,
-0.010624355,
0.012423963,
-0.022075197,
-0.012977176,
-0.0009856189,
0.011164238,
0.015329997,
0.011370859,
-0.009937838,
-0.0044023753,
0.0064919204,
-0.026914144,
0.007678329,
-0.021488657,
0.023928126,
0.020622179,
0.0147034675,
-0.014090267,
-0.01093762,
0.0054321513,
0.017716145,
-0.013283776,
-0.0018812573,
0.0068085184,
0.010031151,
-0.0283405,
-0.02034224,
-0.020488875,
0.015983189,
-0.0089513855,
-0.020568857,
-0.0089380555,
0.011604141,
0.023101639,
-0.012104033,
0.019889005,
0.00461233,
-0.011417516,
0.0078116334,
-0.040791124,
0.07465042,
-0.0012039047,
-0.01606317,
0.01387698,
0.0032726212,
-0.03535231,
-0.13629034,
-0.023368249,
0.013270445,
-0.0067451987,
-0.013757006,
0.0027560669,
-0.0017179595,
0.0049222624,
-0.013310437,
0.016183145,
-0.012057376,
0.008824746,
-0.015809894,
-0.012263998,
0.016076501,
0.0043923776,
0.0071851034,
-0.01635644,
-0.019809023,
0.022061866,
0.0109042935,
-0.0056521036,
-0.014663476,
-0.0034925733,
0.026740847,
0.026340935,
-0.035512272,
0.02399478,
0.013563715,
0.027833942,
-0.0034042592,
-0.012923854,
0.030926604,
-0.016556397,
-0.01017112,
0.016103163,
-0.01946243,
-0.010064476,
0.015623267,
-0.037191905,
-0.00246613,
0.007465042,
0.0028893712,
-0.006138664,
0.0010822645,
-0.021195387,
-0.01124422,
0.005978699,
0.043350566,
-0.0039491407,
-0.019822353,
-0.03207302,
-0.05302846,
-0.014343546,
0.034072585,
-0.01248395,
0.0020745485,
-0.0028527125,
-0.022968335,
-0.006385277,
0.013357094,
-0.00038845715,
-0.0043757143,
-0.00088480744,
0.027673978,
0.0072450903,
-0.020395562,
-0.014343546,
0.027540674,
-0.012577263,
0.018702596,
-0.006845177,
-0.0058987164,
-0.008851407,
-0.00085648027,
0.030580012,
-0.0047156406,
-0.010491051,
-0.020608848,
-0.007431716,
-0.027354049,
-0.010684342,
-0.0022994997,
-0.017036293,
0.03759182,
-0.009311307,
-0.0057354188,
-0.005995362,
0.016303118,
0.0089380555,
-0.004845612,
0.036045488,
-0.011517494,
-0.0040724473,
-0.0012555601,
0.01217735,
0.0082648685,
-0.006991812,
0.026527561,
0.040577836,
-0.009078025,
-0.02002231,
-0.05492138,
0.009784537,
-0.033432726,
0.00246613,
-0.005845395,
-0.02927363,
0.012497281,
-0.03727189,
0.03295283,
0.029540239,
-0.027180752,
0.017582841,
-0.005485473,
-0.010044481,
-0.030580012,
-0.020715492,
0.0037425188,
-0.02618097,
0.0044823578,
0.041830897,
-0.005265521,
-0.028607108,
0.030873282,
0.00018943794,
0.0074183857,
-0.011390855,
-0.024834596,
0.029700203,
-0.0018979204,
-0.008378177,
0.015183363,
-0.03233963,
-0.01446352,
0.013903641,
-0.03199304,
-0.016076501,
0.00408911,
0.0231283,
0.0019479095,
0.020582188,
-0.011064259,
-0.037111923,
0.021102075,
-0.010077807,
-0.012210676,
-0.0009581248,
-0.029113665,
0.017769467,
0.0071917684,
-0.019035857,
0.04161761,
0.038631592,
-0.006768527,
-0.051242184,
-0.007884951,
0.016716363,
0.017049624,
-0.004695645,
-0.012510611,
-0.0025744399,
0.009844525,
0.022701727,
0.018942544,
-0.0012230672,
-0.026407586,
-0.00246613,
-0.026860822,
0.03052669,
0.0062753013,
-0.004029123,
-0.006821849,
0.02683416,
0.0056254426,
-0.014436859,
0.014823441,
-0.0051555447,
-0.016716363,
-0.001309715,
-0.023261605,
0.021422004,
0.006405273,
-0.01946243,
-0.00863812,
0.00060695125,
0.015250015,
0.00021109989,
-0.01340375,
0.020942109,
0.015250015,
-0.007051799,
-0.016769685,
0.0050822273,
0.00091146835,
0.010404402,
0.012743893,
0.0326329,
-0.00028098052,
0.019275805,
-0.004262406,
0.037751786,
-0.0058320644,
-0.014876762,
0.010497715,
-0.027154092,
-0.0068318467,
0.018395998,
-0.0277273,
-0.01341708,
-0.011110916,
-0.0018112726,
0.00953126,
0.0010181118,
-0.0012888862,
0.0068984986,
-0.033779316,
-0.00059612026,
0.0063152923,
0.0028260518,
-0.027860604,
0.021701945,
0.016436424,
0.013277111,
0.0068318467,
-0.00801159,
-0.007758312,
0.0031709766,
0.014383537,
-0.015783232,
0.021182057,
-0.010104468,
0.007645003,
-0.0005457146,
-0.02620763,
0.0072517553,
-0.004085778,
-0.031673107,
0.027887264,
0.013103815,
-0.02712743,
0.067025416,
0.0040357886,
-0.026394257,
0.0012563933,
-0.030153438,
0.022061866,
0.011024267,
-0.0022828365,
-0.022275154,
-0.004055784,
0.012390637,
-0.004935593,
0.021661952,
-0.034285873,
-0.019782363,
0.022381796,
-0.0077249855,
0.012997172,
0.019222483,
-0.0019579073,
0.022568421,
-0.0058553927,
-0.008664781,
0.002011229,
-0.01233065,
-0.009091355,
0.020062301,
-0.015876545,
-0.0040124604,
-0.028793734,
0.023328258,
0.0017812791,
-0.057587467,
-0.019155832,
0.017396215,
-0.023061648,
0.0023311593,
-0.029300291,
-0.006851842,
0.02556777,
-0.0005594616,
0.05185538,
-0.019902335,
-0.011784103,
0.002777729,
-0.02402144,
-0.021035424,
-0.0102177765,
-0.0039924644
] |
TLR3 has been implicated in the pathogenesis of several viral infections, including SIV- and HIV-1-induced inflammation and AIDS. However the molecular mechanisms of these TLR3-mediated effects are not known, and it is not known whether HIV interacts with cellular TLR3 to affect disease process. Here we investigate the effects of TLR3 ligands on HIV-1 transactivation using both primary human macrophages and cells containing integrated copies of the HIV-1 promoter. We demonstrate that TLR3 activation induced upregulation of transcription factors such as c-Jun, CCAAT/enhancer-binding protein alpha (CEB | [
-0.041934837,
-0.0032469656,
-0.007467048,
-0.030490985,
0.0071751126,
0.016322408,
-0.023653219,
0.010081488,
-0.023406697,
-0.010392885,
0.0036654056,
-0.0021424782,
-0.008290953,
-0.0016851135,
0.0046385224,
0.013649581,
0.024626335,
-0.02070792,
0.007441098,
-0.003217772,
-0.025365904,
0.003973559,
-0.018748712,
-0.02182376,
-0.0151157435,
0.017191725,
0.008479089,
-0.04933052,
-0.026053574,
-0.008732099,
-0.004979113,
0.0013672287,
-0.010464246,
-0.00031362736,
0.00634472,
-0.012339118,
0.031918224,
-0.009121345,
0.017827496,
-0.0069804895,
0.012507792,
0.01601101,
0.0063025514,
0.015829362,
-0.013571732,
0.003639456,
0.023666194,
-0.012501304,
-0.01781452,
0.02758461,
0.012235318,
-0.009549517,
0.0007894408,
-0.0024279258,
-0.013266822,
-0.014466999,
0.004499042,
0.017321475,
0.013351159,
-0.030984031,
-0.01494707,
-0.009153783,
-0.029660592,
0.007778445,
0.009095396,
0.021317739,
0.017606921,
0.018099967,
0.011956358,
0.011904459,
0.02081172,
0.028311204,
0.0042038634,
0.017853444,
0.004356318,
-0.01233263,
-0.04346587,
0.004862339,
0.0027555416,
0.013351159,
0.010029588,
-0.009406793,
-0.0073048617,
0.023899741,
0.009964714,
-0.0071232133,
0.017555023,
0.0128386505,
0.017451223,
-0.018748712,
-0.01174876,
-0.009906326,
0.017451223,
0.056155313,
-0.014220476,
0.009614391,
0.008031455,
0.03479865,
-0.011158403,
-0.01778857,
-0.012728364,
-0.024496587,
0.009497617,
-0.009886864,
-0.034020156,
0.0012853248,
-0.0011596306,
0.0008007938,
0.007947118,
-0.0071880873,
-0.043258272,
0.023964617,
0.0006665848,
-0.03690058,
0.023808919,
-0.004349831,
0.021603188,
-0.0033377898,
-0.0035194382,
-0.015258468,
0.016426207,
0.021538313,
0.004580135,
-0.009776577,
0.026806116,
0.0064095943,
0.0010104193,
0.004382268,
-0.03194417,
-0.0038989536,
0.017360399,
0.026935866,
-0.01180066,
-0.002411707,
-0.011151915,
0.022225982,
-0.023964617,
-0.00916027,
-0.012099083,
-0.021136092,
0.0030864014,
0.03347521,
-0.004434168,
-0.009179733,
0.02981629,
0.01789237,
0.03202202,
0.0041227704,
-0.01372743,
0.018774662,
-0.0023954886,
-0.019695878,
0.017632872,
-0.022018384,
0.006111172,
0.014622698,
-0.032774564,
0.04458171,
0.01433725,
-0.012734852,
0.006201996,
-0.020798745,
0.015790438,
0.028908048,
0.021706987,
0.029271346,
0.0062766015,
-0.00603981,
-0.00034829462,
-0.013973953,
-0.007278912,
0.027351063,
-0.0028350127,
0.01068482,
-0.010989729,
0.00025321305,
-0.013999904,
0.009640342,
0.00052305014,
-0.030361235,
-0.019799678,
0.009523567,
0.03220367,
-0.0040611397,
-0.021694012,
-0.023445621,
0.0063285013,
-0.022809852,
-0.014622698,
-0.029323244,
0.0028950218,
0.0056343446,
0.008608838,
-0.040689245,
-0.6281921,
-0.0154271405,
0.0069221025,
0.0134938825,
-0.013039761,
0.009899839,
0.011807147,
-0.009075933,
-0.029245395,
0.027818158,
-0.02060412,
0.028025756,
0.030205537,
-0.030465035,
-0.021408563,
-0.03443535,
-0.031684674,
-0.00025706497,
0.017464198,
-0.0066885543,
-0.008342853,
-0.016049935,
0.033890404,
0.020954443,
-0.002974493,
0.012884063,
0.024003541,
-0.026961816,
0.000105725056,
0.035265744,
-0.0013323587,
0.012034208,
0.0060722474,
-0.016036961,
0.037653122,
-0.013111124,
-0.004077358,
0.032618865,
0.025547553,
0.013364133,
-0.021149065,
-0.00048534188,
0.0050180377,
0.016387282,
-0.007947118,
0.02992009,
0.0001429265,
0.01388313,
-0.0066561173,
0.0038113731,
-0.0023987324,
-0.001480759,
-0.024353864,
-0.007986043,
0.015972085,
-0.0081352545,
0.020915518,
-0.0119368965,
0.006532856,
0.011417901,
-0.019150933,
0.010827543,
0.003370227,
-0.017490149,
-0.0063804006,
-0.0012220722,
-0.010496683,
0.021006342,
0.00029396228,
0.022420606,
0.020474372,
0.022887701,
-0.0060722474,
0.008874822,
-0.008031455,
0.030439086,
-0.0057640937,
0.011884997,
-0.018022118,
0.017567998,
-0.0057770684,
0.014830296,
-0.017023051,
0.00044520083,
0.010386397,
-0.00019725884,
-0.024457663,
0.030516936,
-0.0045022857,
0.012961912,
0.006643142,
-0.0044471426,
-0.031710625,
-0.025080457,
-0.019786702,
0.027039666,
-0.00081539055,
0.00018823723,
-0.019073084,
-0.003251831,
0.00865425,
-0.022342756,
0.015219543,
-0.006565293,
0.021836735,
-0.003415639,
-0.03113973,
-0.0053586285,
0.060618673,
-0.03684868,
-0.0072334995,
0.00050115504,
-0.00017384322,
-0.019021185,
0.00501155,
-0.0143632,
0.018411364,
0.0039508534,
0.012773776,
-0.039599355,
0.033397358,
0.008595862,
0.019176884,
-0.010834031,
0.017801546,
0.009257582,
0.003088023,
-0.0041000643,
0.004489311,
-0.013416033,
0.010230699,
-0.0072594495,
0.013454958,
-0.022498455,
0.020694945,
0.008563425,
0.02758461,
0.016594881,
0.003206419,
-0.017243626,
-0.030153638,
-0.01444105,
0.003428614,
0.011391951,
-0.018631939,
-0.018761687,
-0.004492555,
0.006503662,
-0.00075822,
-0.012760801,
0.0068702027,
-0.015699614,
-0.007908193,
0.005095887,
0.012598615,
-0.0077849324,
-0.004356318,
-0.014415099,
-0.009666291,
-0.019605055,
-0.011009192,
0.019656954,
0.008453139,
0.007473535,
0.008498551,
0.009964714,
0.020539246,
0.009601417,
0.00039776138,
-0.039599355,
0.008777511,
-0.027896008,
-0.018099967,
0.012916501,
0.0062441644,
0.021966483,
0.0084142145,
-0.009471668,
-0.016555956,
-0.0013785817,
-0.004992088,
-0.003357252,
0.0083493395,
0.009387331,
0.020279748,
0.0074475855,
-0.0062636267,
0.011826609,
0.029167546,
0.03687463,
-0.025352929,
0.0014175064,
-0.025897875,
0.02070792,
0.006004129,
-0.004197376,
0.02078577,
0.020539246,
-0.0064031067,
0.010055537,
-0.013740405,
-0.005352141,
0.00662368,
-0.036251836,
-0.005517571,
-0.013480908,
0.0060560284,
-0.024807984,
0.019410431,
-0.010756182,
0.012040695,
0.0041941325,
-0.008368802,
-0.0036881117,
-0.002507397,
0.031399228,
0.0033896894,
-0.0054689148,
0.002786357,
-0.020941468,
-0.008102817,
0.012449404,
0.015608789,
-0.02999794,
-0.0125272535,
0.012961912,
-0.0032583186,
0.009802528,
-0.021123117,
-0.024911784,
-0.026040599,
-0.0125921285,
0.027273213,
0.023238024,
0.006714504,
-0.0051023746,
-0.0070388764,
-0.008102817,
0.017931294,
0.0049239695,
-0.004158451,
0.015258468,
-0.0066269236,
0.015323342,
-0.006085222,
0.006260383,
0.017983194,
0.00019482605,
0.00010096084,
0.029011847,
-0.004106552,
0.012514278,
-0.017152801,
-0.020863619,
-0.00035356567,
-0.012397504,
0.0048655826,
0.016023986,
0.047514036,
0.014985994,
0.022225982,
-0.01233263,
0.021330714,
-0.012669978,
0.00860235,
0.011482775,
-0.026676368,
-0.0063771573,
-0.000051266008,
0.012442917,
-0.015647713,
-0.017567998,
0.018826561,
-0.045360204,
-0.00042614396,
0.018048069,
0.018203767,
-0.009997151,
-0.007960093,
0.007914681,
0.0035032195,
-0.023873793,
0.0345132,
0.010898905,
-0.012235318,
-0.0107237445,
-0.0075124595,
0.0046579847,
-0.0073437863,
0.016945202,
0.009893351,
0.007921169,
0.04484121,
0.016711654,
-0.0031610068,
-0.009633854,
0.023328846,
-0.009977688,
0.014570799,
-0.009588442,
0.0035291694,
0.009400305,
-0.0073502734,
-0.009056471,
0.021616163,
-0.0008247163,
0.0073502734,
-0.01550499,
-0.00949113,
-0.006701529,
0.02349752,
-0.002729592,
0.0013550648,
-0.012319655,
0.018515164,
0.027973857,
0.009497617,
0.019267708,
0.0011328699,
-0.005511083,
-0.023614295,
-0.030490985,
0.002285202,
-0.004126014,
0.008673712,
0.009906326,
-0.0048363893,
0.02179781,
-0.0020484102,
0.007888732,
0.006857228,
-0.03889871,
0.021304766,
-0.0065425867,
-0.0053099724,
-0.008848873,
0.004382268,
0.009302994,
0.025923824,
0.030049838,
0.013922054,
-0.024444688,
0.007382711,
0.0012723499,
0.03116568,
0.000022237233,
0.025352929,
0.030490985,
0.032541018,
-0.019929428,
0.0036978428,
0.022096233,
-0.006941565,
-0.0109702675,
0.005819237,
0.014402125,
-0.0012739717,
0.011145428,
-0.019553155,
-0.0345132,
-0.015829362,
0.010847006,
0.013364133,
0.008952673,
0.0012853248,
0.023354797,
0.015543915,
0.006753429,
-0.009088908,
-0.0040287026,
-0.000839313,
0.01035396,
-0.0007813315,
-0.004025459,
0.027091565,
-0.020240825,
-0.00776547,
-0.02476906,
0.00827149,
-0.0038308355,
-0.010483709,
-0.009432743,
0.00058549177,
-0.02370512,
-0.013532807,
-0.020643046,
0.018177817,
-0.019656954,
0.008874822,
-0.006565293,
0.0015407678,
-0.012125032,
-0.028025756,
0.0010809703,
0.0057997745,
-0.013935029,
-0.021356665,
0.011424388,
-0.0027490542,
0.006669092,
0.014752447,
0.01619266,
0.019228783,
0.05304134,
-0.013072199,
-0.026300097,
-0.007862782,
-0.030490985,
0.013844205,
-0.0030117957,
0.0138701545,
-0.02540483,
0.0015529318,
-0.00562137,
-0.02179781,
0.0043790243,
0.0039508534,
-0.0062993076,
-0.010496683,
0.034046102,
0.027506761,
0.018761687,
-0.0068247905,
-0.0074021732,
-0.023315873,
-0.03679678,
-0.009815502,
-0.006448519,
-0.0141815515,
-0.027325112,
0.008900773,
0.0151157435,
-0.019436382,
-0.0005214283,
0.027039666,
-0.012371555,
-0.004966138,
0.0027312138,
0.0069804895,
0.04247978,
0.012682952,
0.010749694,
0.015414166,
-0.039806955,
-0.04403677,
-0.015816387,
0.013701481,
0.004233057,
0.003078292,
-0.0075708465,
0.018138893,
-0.0031674944,
-0.0062182145,
-0.004885045,
0.00186514,
0.019786702,
0.01852814,
0.003532413,
-0.02203136,
0.013519833,
-0.009348406,
0.013156536,
-0.00039897778,
-0.018476238,
0.0015886128,
0.017671796,
-0.0059165484,
-0.022394655,
0.010075,
-0.024885833,
-0.012974887,
0.039729103,
-0.014350225,
-0.00548189,
-0.0034253702,
0.005971692,
-0.019189859,
-0.006094953,
-0.015998036,
-0.02989414,
0.0063285013,
-0.011619012,
0.01662083,
0.0010047428,
0.026909916,
-0.015959112,
0.01842434,
0.010425322,
0.0076097716,
0.0011109747,
-0.010159337,
0.027896008,
-0.016465131,
0.017490149,
0.015686639,
-0.0033004868,
-0.00056400214,
-0.020188924,
0.008472601,
0.005154274,
-0.012215856,
-0.032592915,
0.0027133734,
-0.016426207,
-0.021681037,
0.015245493,
-0.008900773,
-0.005232123,
-0.03106188,
0.009653316,
0.034072053,
-0.009315969,
0.012228832,
0.01299435,
0.0017889126,
-0.0093808435,
0.021668062,
-0.022329781,
0.017399324,
0.0011523322,
-0.006146853,
0.0010598861,
0.01235858,
0.0050212815,
-0.0064290566,
-0.00487207,
0.017983194,
-0.014570799,
-0.008641275,
0.021603188,
-0.010029588,
-0.017710721,
-0.019708853,
-0.019099034,
-0.016581906,
-0.02758461,
-0.016906278,
-0.03443535,
0.000018106557,
-0.00005945134,
0.004353075,
0.012209369,
0.0026679612,
-0.001819728,
0.032696716,
0.014012878,
0.03557714,
-0.024379812,
0.012501304,
0.016036961,
0.011301126,
-0.030750483,
-0.009315969,
0.004735834,
-0.0034188828,
0.029712493,
0.025923824,
-0.042817127,
-0.013441984,
0.021408563,
0.007032389,
0.003277781,
-0.021460464,
0.017386349,
0.006471225,
-0.008011993,
-0.0119693335,
-0.016737605,
-0.030672634,
0.022446554,
-0.022420606,
0.022550354,
-0.0016478107,
-0.0017694503,
-0.0010298816,
0.03557714,
0.0064874436,
-0.0019527206,
-0.009244607,
-0.036329683,
0.005180224,
-0.046943143,
0.021019317,
-0.0060203476,
-0.010133387,
0.029764391,
0.019073084,
-0.004979113,
-0.011301126,
0.004301175,
0.013195461,
0.015816387,
-0.010885931,
0.052184995,
-0.007467048,
0.008777511,
0.01733445,
-0.013597682,
-0.02116204,
0.018644912,
0.0043206373,
-0.008576401,
-0.040896844,
-0.0060917097,
0.024976658,
0.0005027769,
-0.01035396,
0.01900821,
-0.013688506,
-0.0073762233,
-0.03370876,
-0.039417706,
0.01784047,
-0.035914488,
-0.0034448325,
0.0048331455,
0.018748712,
0.03705628,
0.0071491627,
0.007694108,
-0.0037497424,
0.026858017,
-0.04245383,
0.0052450984,
0.012650515,
0.007940631,
-0.011813635,
-0.013338184,
-0.024963683,
-0.047539987,
-0.001200988,
-0.017399324,
-0.036952477,
-0.02654662,
0.009620879,
0.0066626044,
0.018787637,
-0.00517698,
0.039469607,
-0.030490985,
0.009290019,
0.0024538755,
0.0026566081,
0.011158403,
-0.022290856,
-0.009672779,
0.031425178,
-0.00070226577,
0.005407284,
0.008128767,
0.007006439,
-0.001993267,
-0.002496044,
-0.030361235,
-0.002865828,
0.008005505,
-0.0012196394,
-0.0059619606,
0.00044925546,
0.004434168,
-0.0027814915,
0.011106503,
-0.00044479535,
-0.022225982,
-0.0068831774,
0.020630071,
0.009607904,
-0.0021668063,
-0.00515103,
-0.008563425,
0.02761056,
-0.018995235,
-0.027299162,
-0.012449404,
-0.032618865,
0.0072075496,
-0.0037464986,
-0.010392885,
-0.020266773,
-0.0062993076,
-0.052366644,
0.0013315479,
-0.011670911,
0.004930457,
0.0053553847,
0.014077753,
-0.013636607,
0.01101568,
0.00501155,
-0.0069804895,
0.018151866,
-0.03337141,
0.002192756,
-0.012099083,
0.029011847,
0.020033225,
-0.026559595,
-0.0040416773,
0.048889376,
0.0026241709,
-0.011826609,
0.020357598,
-0.025677301,
-0.0021295033,
-0.010217723,
0.022070283,
-0.0034837571,
-0.0022381681,
0.01601101,
-0.025456728,
0.00044479535,
0.030542884,
0.0013104636,
-0.015959112,
-0.00275392,
-0.0019429894,
0.008141742,
0.00072578277,
0.0035194382,
-0.046476047,
0.028285254,
-0.014025853,
0.008900773,
0.0036783805,
-0.007356761,
-0.0033150837,
-0.0030231487,
-0.019280683,
0.011203815,
0.0094132805,
-0.013480908,
0.012339118,
0.018670863,
0.009049984,
-0.019786702,
0.0032307468,
-0.015751513,
-0.020539246,
0.011067579,
-0.005559739,
-0.012215856,
-0.052159045,
0.0032356125,
-0.010321523,
-0.020954443,
-0.0032712934,
-0.008699662,
-0.018644912,
-0.024509562,
0.0059360107,
0.019345557,
-0.013896104,
-0.011093529,
0.010211236,
0.0068247905,
-0.01547904,
-0.0033037306,
-0.00056238024,
-0.02426304,
0.008284465,
0.1951423,
-0.021447489,
-0.009049984,
0.0037497424,
-0.016296457,
0.02761056,
0.017736671,
-0.005365116,
-0.00916027,
-0.0050666933,
0.021616163,
0.0042006196,
-0.0010209614,
0.002645255,
-0.016361333,
-0.0014612967,
-0.010671845,
-0.006416082,
-0.015414166,
-0.023276947,
0.021252865,
0.021681037,
-0.0143632,
-0.018878462,
0.042064585,
0.011398438,
-0.03780882,
0.013714456,
0.01672463,
-0.0070388764,
-0.03562904,
0.016309433,
0.01299435,
0.0017516097,
0.007694108,
0.005099131,
-0.020305699,
-0.010853494,
0.015362266,
-0.012092595,
-0.008479089,
0.0018846024,
-0.021395588,
-0.021590212,
0.002179781,
0.03690058,
0.004346587,
-0.013896104,
-0.0071880873,
0.011703349,
-0.021123117,
-0.023458596,
0.008900773,
0.018657887,
0.003182091,
-0.0016964665,
0.026754217,
0.009640342,
-0.008018481,
0.036433484,
-0.012306681,
-0.0011596306,
-0.0143632,
0.013000837,
-0.017464198,
0.026702318,
0.002063007,
0.020513296,
0.0144280745,
-0.04372537,
0.0071751126,
-0.012644027,
-0.020850644,
0.0033085963,
-0.032515068,
0.0016916009,
0.041675337,
0.0034610513,
0.04515261,
0.01654298,
0.015206568,
-0.017580973,
-0.025080457,
0.02081172,
0.009880377,
-0.011709835,
0.006740454,
0.0040059965,
-0.018061044,
0.026832066,
-0.008206616,
-0.016244559,
-0.0135587575,
-0.021304766,
0.0053910655,
-0.0031772256,
-0.013636607,
-0.028959949,
0.0058841114,
-0.023795944,
-0.03443535,
0.08231268,
-0.002564162,
-0.011709835,
-0.016140759,
0.022148132,
0.007356761,
-0.014752447,
0.00015387405,
-0.023731068,
0.015920186,
-0.018917385,
0.019176884,
-0.0062766015,
0.002948543,
0.006331745,
0.003824348,
-0.02258928,
0.037237927,
0.008926722,
-0.003639456,
-0.010788619,
-0.0064031067,
0.027117515,
-0.0030620734,
-0.0050893994,
-0.020591145,
0.014583773,
-0.0062928204,
-0.01547904,
0.0045055295,
0.01845029,
-0.013649581,
0.029063748,
0.014116677,
-0.008894285,
0.0058549177,
-0.017217675,
-0.012955425,
0.013072199,
-0.013240872,
-0.012877575,
0.02057817,
-0.013117611,
-0.014882196,
-0.0017905345,
0.020305699,
0.0061500967,
-0.028051706,
0.008297441,
-0.015686639,
-0.011424388,
-0.0015221165,
-0.01606291,
0.018593013,
-0.02426304,
-0.004220082,
-0.0045574293,
0.0064647375,
0.022615228,
-0.015959112,
0.019514231,
0.018774662,
-0.023795944,
-0.015881263,
-0.0028415003,
-0.1603696,
0.014155602,
0.003555119,
-0.011949871,
0.025664328,
0.02116204,
0.011670911,
0.004826658,
0.005407284,
0.0076097716,
0.030413136,
0.0037983982,
-0.022796877,
-0.009568979,
0.0011628743,
-0.011956358,
-0.024366839,
0.02357537,
0.023821892,
0.0037854232,
0.021032292,
-0.03111378,
-0.0072464747,
-0.017490149,
0.0039703157,
0.010159337,
0.0018764931,
-0.02530103,
-0.0032485875,
-0.0025933555,
-0.011067579,
0.020448422,
0.035888538,
-0.02761056,
0.025443753,
0.0009877133,
0.0051737363,
0.0010371801,
0.004661228,
0.017710721,
0.04515261,
0.010431809,
0.0023500763,
0.002959896,
-0.03199607,
0.031840373,
0.0032842683,
0.000037252117,
0.015660688,
-0.0086283,
0.01903416,
-0.023588344,
0.011807147,
0.02476906,
0.018333515,
0.0033313022,
0.0053294348,
0.017360399,
-0.013973953,
0.0016478107,
-0.02251143,
0.012488329,
0.037289824,
-0.017619897,
0.028311204,
-0.039236058,
0.002599843,
0.010756182,
-0.018813586,
0.03311191,
-0.026507694,
-0.005271048,
-0.02415924,
-0.030646684,
0.011859047,
0.031295426,
-0.033397358,
0.011262202,
0.009873889,
0.0035745814,
-0.0063609383,
0.013649581,
-0.013935029,
-0.013377109,
-0.041934837,
-0.008161204,
0.00042817128,
0.013429008,
0.0046709594,
-0.0141815515,
0.013571732,
-0.02981629,
-0.0022592521,
-0.0287264,
0.006633411,
0.022770926,
0.004790977,
0.016439183,
-0.02761056,
-0.004158451,
0.028077656,
-0.025573503,
-0.0013972332,
0.017542047,
-0.0011701726,
-0.017567998,
-0.046398196,
-0.0034123953,
0.05511732,
-0.008050918,
0.0000071019767,
-0.0014353469,
0.0024571193,
0.031321377,
-0.004677447,
0.011826609,
-0.0144280745,
0.012118544,
0.005666782,
-0.023354797,
0.058438893,
-0.00050764246,
-0.02527508,
0.009594929,
-0.020500321,
-0.03350116,
-0.12725769,
-0.0034610513,
0.0065166373,
-0.0046936655,
-0.03197012,
0.039573405,
0.012261269,
0.004826658,
-0.0064550065,
0.013052736,
-0.052755892,
0.0040903334,
-0.005932767,
-0.021382615,
-0.003126948,
0.0045606727,
0.016426207,
0.008615325,
-0.026728267,
0.027273213,
-0.004512017,
-0.023471572,
0.004956407,
-0.010516146,
0.015868288,
0.003474026,
-0.02984224,
0.0025560528,
-0.0020159732,
0.008355827,
-0.00473259,
-0.0009779821,
0.02575515,
0.006260383,
-0.014402125,
-0.004512017,
0.006831278,
-0.009348406,
0.029712493,
-0.008109304,
0.015375242,
0.026780168,
0.0016023986,
0.011119478,
0.0060560284,
-0.013299259,
-0.015258468,
0.02591085,
0.03145113,
-0.020383548,
-0.017853444,
-0.025106406,
-0.044400062,
-0.018190792,
0.018567063,
-0.010587508,
0.0048461203,
0.03666703,
-0.0119368965,
-0.0010023101,
0.0074475855,
0.0087256115,
0.001912174,
0.0144280745,
0.038535416,
-0.033163812,
0.02238168,
-0.018048069,
0.026728267,
-0.02245953,
0.0059068175,
-0.042791177,
-0.028389053,
-0.0034675386,
-0.0020305698,
0.022018384,
-0.02171996,
-0.031477075,
-0.0038405666,
-0.016478106,
-0.0032972433,
-0.011391951,
0.011437363,
-0.008174179,
0.024301963,
-0.004116283,
-0.015167643,
-0.0032485875,
0.008920235,
-0.008057405,
-0.019137958,
0.041130394,
-0.007940631,
0.000032690634,
-0.016633805,
-0.00331184,
-0.016763555,
-0.0037562298,
0.016906278,
0.023912717,
-0.029712493,
0.005631101,
-0.06622382,
0.022744978,
-0.008115792,
-0.0024149509,
0.009335431,
-0.011171378,
0.00279771,
-0.027947906,
0.0033085963,
0.0031285696,
0.0009544651,
0.009867402,
-0.014726497,
0.018048069,
-0.018437315,
-0.011709835,
0.04022215,
0.0035129506,
0.015063844,
0.025871925,
0.017036026,
-0.01563474,
-0.0028398784,
0.03453915,
0.007843319,
0.009964714,
0.018670863,
0.006192265,
-0.017593946,
0.013584707,
0.0070972634,
-0.023510495,
-0.01667273,
-0.010749694,
-0.01723065,
-0.028285254,
0.0035486317,
0.033163812,
0.013532807,
0.039936703,
-0.016997103,
-0.034357503,
-0.015232517,
0.00865425,
0.02134369,
-0.008991597,
-0.028337155,
0.021706987,
0.0023646732,
0.0033799582,
0.036070187,
0.02179781,
-0.026001673,
-0.004573648,
-0.025236156,
0.013085173,
0.022213006,
-0.027947906,
-0.016400257,
-0.016257534,
0.01611481,
0.036070187,
0.003264806,
0.028648552,
0.0171009,
-0.009114859,
-0.037575275,
-0.0017418786,
-0.0068702027,
-0.0024149509,
-0.025249131,
0.007278912,
0.0039930213,
0.0077589825,
0.007908193,
0.022498455,
-0.0200462,
0.009802528,
-0.027792208,
-0.008952673,
-0.00087985955,
-0.018281616,
-0.00781737,
-0.015881263,
0.028622601,
0.004664472,
-0.0035908,
0.010133387,
-0.0003661351,
0.0066626044,
0.0011239497,
0.021110142,
-0.0020743601,
0.012910013,
0.018061044,
0.017827496,
0.018125918,
-0.0071751126,
-0.0017094414,
0.029764391,
0.016491082,
-0.011417901,
-0.0008571535,
-0.02999794,
-0.0109053925,
0.022122182,
-0.056103412,
-0.04839633,
-0.008751562,
0.007064826,
0.022018384,
-0.011787685,
-0.004823414,
-0.008342853,
-0.014025853,
0.005199686,
0.0014280485,
0.008764536,
-0.003474026,
0.037730973,
0.0012277487,
0.030646684,
0.0008603972,
-0.009958226,
0.0061857775,
0.00515103,
0.034772698,
-0.017723696,
0.019734804,
-0.011794172,
0.010503171,
0.017944269,
-0.024237089,
-0.0013420898,
-0.010451271,
-0.0114698,
0.0027328357,
0.027870057,
-0.020396523,
0.082572185,
0.0012431564,
-0.019099034,
-0.0119693335,
-0.020668995,
0.03100998,
0.008232566,
0.012112057,
-0.031554926,
-0.03106188,
0.018605988,
-0.01555689,
0.0030117957,
-0.051198903,
-0.026429845,
0.012669978,
-0.010561558,
0.021123117,
-0.0016388905,
-0.005043987,
0.025365904,
0.0025398342,
0.0020159732,
-0.0014077752,
-0.02088957,
-0.0058516744,
0.038768962,
0.006889665,
-0.007019414,
-0.04842228,
-0.002752298,
0.009127833,
-0.03202202,
-0.008939697,
0.0015553646,
-0.026806116,
-0.03108783,
-0.0034902447,
0.023860818,
0.010224211,
-0.008232566,
0.0012999215,
-0.01677653,
-0.032800514,
0.01547904,
-0.006915615,
-0.029452994,
-0.0011742273,
-0.008569913
] |
Although a moderate-sized patent ductus arteriosus (PDA) needs to be closed by the time a child is 1-2 years old, there is great uncertainty about whether it needs to be closed during the neonatal period. Although 95% of neonatologists believe that a moderate-sized PDA should be closed if it persists in infants (born before 28 weeks) who still require mechanical ventilation, the number of neonatologists who treat a PDA when it occurs in infants who do not require mechanical ventilation varies widely. Both the high likelihood of spontaneous ductus closure and the absence of randomized controlled trials, specifically addressing | [
0.005643705,
0.0059976885,
0.009297085,
-0.02767753,
-0.017685834,
0.017685834,
-0.03270009,
0.036413584,
-0.024191123,
0.017832771,
0.005096032,
0.035024364,
-0.00038967445,
0.02130582,
0.004281201,
-0.013945628,
0.02704971,
0.0032242585,
-0.0066422066,
-0.01972959,
-0.030295674,
0.0034763885,
-0.03991335,
-0.025914289,
-0.018126644,
0.0216932,
0.036199857,
-0.020851653,
-0.009637712,
-0.015561932,
0.014680311,
-0.0029788075,
-0.018968191,
-0.015842447,
-0.007507129,
-0.004778782,
-0.0071464665,
-0.0031307535,
0.023496512,
-0.0015361563,
0.015321489,
0.0010318963,
-0.005099371,
0.015361563,
-0.0068392353,
0.0017899561,
-0.008989854,
-0.016376762,
-0.01273674,
0.004558377,
0.010579442,
0.004651882,
0.0076073133,
0.024124334,
-0.016924435,
-0.0019201954,
-0.015655437,
0.015308131,
-0.007814361,
-0.025526911,
-0.018086571,
-0.0066722617,
-0.007814361,
0.027597383,
-0.032619946,
0.003613307,
0.013144155,
0.05094696,
0.026502036,
0.035718974,
0.055248197,
0.016857646,
0.03411603,
-0.004014043,
0.006425141,
0.011521173,
0.0027283472,
-0.0013416322,
-0.024992596,
0.006154644,
-0.0062514883,
-0.04584425,
-0.00069753185,
0.041569725,
0.02137261,
-0.012035451,
0.0057639256,
-0.0051795184,
-0.02596772,
0.0131374765,
-0.00022750141,
0.030028516,
0.006127928,
-0.0014601834,
0.0062949015,
0.001223081,
0.015147837,
0.01986317,
0.018928118,
-0.0077141766,
-0.018166719,
-0.005957615,
-0.008255171,
-0.007420303,
-0.0015169544,
0.0034630308,
-0.00021393482,
-0.010005053,
0.002800146,
-0.0066088117,
-0.007533845,
0.059789877,
-0.00901657,
-0.0036834357,
0.013124119,
-0.0040708142,
0.005142784,
0.035772406,
-0.012449545,
-0.0043546692,
0.02818513,
0.021653125,
0.021893566,
-0.02445828,
0.026755836,
0.0076674237,
-0.041756738,
-0.015642079,
-0.0076006344,
-0.018140003,
-0.021212315,
0.027490519,
0.032673378,
0.015468426,
-0.012082203,
0.010913389,
-0.015548574,
-0.0016914418,
-0.022922125,
-0.026969561,
0.010005053,
0.012022093,
-0.026114658,
-0.023590019,
-0.015909236,
0.019996747,
0.033074114,
0.015241343,
0.0018049837,
-0.011240657,
0.008435502,
-0.024685364,
-0.020250548,
-0.0052797026,
0.004535001,
0.018647602,
0.015161195,
0.021385968,
-0.006455196,
0.003890483,
-0.028906455,
0.011741578,
0.006705656,
0.00016227739,
0.009350517,
0.018754466,
0.013625039,
-0.006966135,
0.008455539,
-0.013030613,
-0.021078737,
0.016163036,
-0.0315246,
0.0038470698,
0.021172242,
0.022093935,
-0.010098558,
0.019929959,
-0.010746416,
-0.020384127,
-0.010572763,
-0.02786454,
0.007887829,
0.026809268,
-0.019181918,
-0.00046168178,
0.028051551,
0.010672947,
0.008328639,
-0.017325172,
0.011307446,
0.0068993457,
-0.014399796,
0.005640365,
-0.6266449,
0.0016814233,
-0.018019782,
-0.01942236,
-0.007273366,
0.036092997,
-0.0029604405,
-0.023189282,
-0.0065720775,
0.01840716,
0.004291219,
0.009777969,
-0.000090478774,
0.008114913,
-0.015361563,
-0.0044982666,
0.014747101,
0.0013875499,
0.019783022,
-0.022922125,
0.01822015,
0.023937324,
-0.0075805974,
0.0034029202,
0.0096644275,
0.009390591,
0.045737386,
-0.010045127,
0.020143684,
-0.0020404165,
-0.015722226,
0.0062815435,
-0.010005053,
0.0045183036,
0.04039423,
-0.0074737347,
-0.004368027,
0.021572977,
-0.0162699,
0.028158413,
-0.020798221,
0.023469796,
0.022748472,
0.012850282,
-0.01745875,
0.01399906,
0.021719916,
-0.03171161,
0.009103396,
-0.027490519,
0.0052396287,
-0.0056971363,
0.006966135,
0.0039806487,
-0.0051928763,
-0.013918912,
0.032058913,
-0.005079334,
0.00680918,
-0.012583124,
0.015147837,
-0.012128957,
0.019676158,
-0.0029454129,
0.008849597,
-0.0089030275,
0.007533845,
-0.002825192,
-0.013985702,
0.009377233,
-0.012142314,
0.031444453,
0.017739266,
-0.0013950637,
0.027343582,
0.014693669,
0.014586806,
0.034329753,
-0.004942416,
0.021479473,
0.01279685,
-0.001676414,
-0.022935482,
0.0055168048,
0.024992596,
0.020450916,
0.000876611,
0.0068926667,
-0.013498139,
-0.015174553,
-0.016416837,
0.020450916,
0.005176179,
-0.032887105,
-0.00069127034,
0.018006423,
-0.014773817,
-0.005917541,
0.02225423,
0.014252859,
-0.013351202,
0.010579442,
-0.009884832,
-0.035291523,
0.02925376,
0.015321489,
-0.002150619,
-0.01027889,
0.025874216,
-0.039165307,
0.0023810423,
-0.01128073,
-0.0068358956,
-0.005977652,
0.024191123,
-0.02326943,
-0.008996533,
-0.015308131,
-0.005189537,
-0.010365716,
0.017204951,
-0.011487778,
0.003499765,
-0.018380444,
0.0049390765,
0.0070529613,
-0.005647044,
-0.025086101,
0.012382756,
-0.031070432,
0.008642549,
0.022855334,
0.008368713,
0.0005101041,
0.014466586,
0.010980179,
0.010285568,
-0.0023159226,
-0.01659049,
-0.018687677,
-0.0023760332,
0.011327484,
-0.00092586817,
-0.0057138335,
0.001821681,
-0.028772876,
0.0015787346,
-0.00042181683,
-0.020798221,
0.012148993,
-0.031738326,
-0.027263436,
0.0145200165,
0.01229593,
0.005156142,
-0.011935267,
0.011982019,
-0.027437087,
-0.03165818,
-0.018901402,
-0.0018200113,
0.025566984,
-0.031043716,
-0.009831401,
-0.011541209,
-0.0046118083,
0.001588753,
-0.0108466,
-0.006458536,
-0.032753523,
0.0025263093,
-0.01488068,
0.014466586,
-0.015388279,
0.0034763885,
-0.017672477,
-0.0017999745,
-0.031871904,
-0.03959276,
0.012696666,
-0.007293403,
-0.020905085,
0.020290622,
0.0071464665,
0.050172202,
0.008989854,
0.00750045,
-0.0014226143,
-0.008014728,
0.021052022,
0.009737896,
0.026622258,
-0.028104981,
0.03272681,
-0.001601276,
-0.016724067,
0.0005401593,
0.0081282705,
0.0032760203,
0.040287368,
0.0018951494,
-0.022387808,
0.034890786,
-0.014052491,
0.007426982,
-0.014105923,
0.013524855,
-0.011935267,
0.0032693415,
0.014386438,
-0.015989384,
0.008475576,
0.018674318,
-0.0052964,
-0.013337844,
0.038871434,
0.012409472,
-0.0034262966,
-0.008983175,
0.01910177,
0.0160161,
-0.03769594,
0.02256146,
0.017071372,
-0.005900844,
-0.0211856,
0.033207692,
0.026047869,
-0.01614968,
-0.044054292,
-0.0021522886,
0.01342467,
-0.0060477806,
0.009070002,
-0.012249177,
0.03481064,
0.015308131,
-0.0061312676,
-0.0027417052,
0.019462433,
-0.0046952954,
0.014199427,
0.025807427,
0.007293403,
-0.0030238903,
-0.008669265,
0.028452286,
0.018006423,
-0.04442831,
-0.02030398,
-0.0070396033,
-0.021145526,
-0.010071842,
-0.007760929,
0.00088913395,
-0.010926747,
0.013878838,
0.0038170146,
0.0038403908,
0.015615364,
0.011748256,
0.008522328,
-0.008896349,
-0.0063015805,
0.029414054,
-0.0077074976,
-0.00092336355,
-0.003486407,
0.023069061,
-0.020851653,
-0.005653723,
-0.012589803,
0.017632402,
-0.031871904,
0.017512182,
0.0020454256,
-0.02181342,
0.0077008186,
0.0073802294,
0.0068793087,
0.0068225376,
-0.023603376,
0.018233508,
0.015414995,
-0.015201269,
-0.0039138594,
0.019649444,
0.027730962,
-0.0204242,
0.01745875,
-0.027570667,
0.0021923622,
0.0044114403,
0.017512182,
0.006722354,
-0.017164877,
0.018260224,
-0.0055835946,
0.0049157003,
-0.017098088,
-0.0017089739,
0.016537057,
-0.008228455,
-0.03334127,
0.008602476,
0.01683093,
-0.0060878545,
-0.019996747,
0.008789486,
-0.01840716,
-0.011187226,
-0.02288205,
-0.017952992,
0.0131641915,
-0.01418607,
-0.02459186,
0.006698977,
0.0027283472,
0.019221991,
-0.000605279,
-0.006355012,
0.018754466,
-0.013524855,
-0.0148940375,
0.05353839,
-0.007326798,
0.015895879,
0.02371024,
-0.0211856,
-0.0025897592,
-0.013785333,
0.00084655575,
0.047634203,
0.009924905,
0.016243184,
0.0033010663,
0.010900031,
0.00668228,
0.03032239,
0.019996747,
0.0216932,
-0.011714862,
-0.025874216,
-0.008208418,
-0.014199427,
-0.000583155,
0.012282572,
0.021345895,
0.017659118,
-0.014039133,
0.026822625,
0.023403008,
0.008288565,
-0.0036233254,
-0.014987542,
0.018313656,
0.0057772836,
0.028826308,
-0.00030076105,
0.0037001332,
0.02427127,
-0.020330695,
0.024645291,
0.05075995,
0.013985702,
0.022361092,
-0.0057271915,
-0.004374706,
0.021773346,
-0.009918227,
0.0024444922,
0.0066288486,
0.014386438,
-0.03569226,
0.026341742,
-0.009250333,
-0.013625039,
0.012028772,
0.03227264,
0.013391276,
-0.008642549,
-0.0060544596,
0.016617205,
0.002893651,
0.0004508285,
-0.01689772,
0.014800533,
-0.0042077326,
0.0005247143,
-0.025112817,
-0.016376762,
0.007266687,
-0.034757208,
-0.04116899,
-0.017485466,
-0.014573448,
-0.036173142,
0.0055001075,
0.01273674,
0.003107377,
0.030616263,
-0.006511967,
0.016750783,
0.016603846,
0.014226143,
-0.017645761,
-0.014292933,
-0.0031708272,
0.009878153,
0.016523698,
-0.022040503,
-0.01984981,
-0.029841507,
0.012509656,
0.046939593,
0.008849597,
0.013324486,
-0.014573448,
0.0057706046,
0.011334162,
0.022267587,
0.027129857,
0.0017699193,
-0.02527311,
-0.004765424,
0.024231197,
-0.010619516,
-0.009250333,
-0.0068993457,
-0.016443552,
-0.016563773,
0.017886203,
-0.011688146,
-0.023122493,
0.027410373,
-0.00857576,
-0.010018411,
-0.028639298,
0.028131697,
0.031444453,
-0.020103611,
0.016924435,
0.024391491,
-0.024297986,
-0.0011504475,
0.01866096,
0.026689047,
0.021946998,
0.0014351374,
0.013251018,
-0.0030138718,
-0.025954364,
-0.03481064,
0.015481784,
0.0077141766,
0.015094406,
0.021345895,
-0.03929889,
-0.03884472,
-0.017485466,
0.021212315,
0.00126065,
-0.014920753,
-0.009938263,
0.0070596403,
0.022347735,
0.0031908639,
-0.011233978,
0.027143214,
-0.027276793,
-0.009363875,
0.00065537106,
-0.019809738,
0.0071397875,
-0.025126174,
-0.00093755627,
0.006421801,
0.0000128817455,
-0.005586934,
-0.04905014,
0.020771505,
-0.020317337,
0.010459221,
0.014426512,
0.0070262454,
-0.008589118,
0.0071531455,
0.03013538,
0.0068525933,
-0.0014768807,
0.00005262275,
0.002452841,
0.014052491,
0.023736956,
0.010205422,
0.024284627,
0.015842447,
-0.014252859,
0.054045986,
-0.0031758363,
-0.0055034473,
-0.012189067,
-0.0042077326,
-0.027597383,
0.009590959,
0.0013349532,
0.026328383,
-0.0002855247,
-0.030776558,
-0.003245965,
0.0108399205,
-0.0022290964,
0.0029955048,
-0.030562833,
0.027210005,
-0.01942236,
0.029467486,
-0.0014434861,
0.023549944,
0.0131374765,
-0.030723127,
-0.0123894345,
0.0053364737,
0.0028869722,
0.0058540916,
0.010960141,
0.009944943,
-0.0137452595,
-0.031364307,
-0.0050392607,
-0.009183544,
-0.026128016,
0.005640365,
-0.02496588,
-0.017204951,
-0.0052429684,
0.0003606628,
-0.040741537,
0.013758617,
-0.0050526187,
-0.0044748904,
0.040314086,
-0.019823095,
0.005156142,
-0.016229825,
-0.02642189,
0.00058649445,
-0.011187226,
0.038684424,
0.022962198,
-0.003963951,
-0.022013789,
-0.021572977,
0.0073535135,
0.0057205125,
0.014974185,
0.026381815,
0.0031557993,
0.016670635,
0.008482255,
0.022013789,
-0.0048823054,
-0.028906455,
0.024645291,
-0.01569551,
-0.032673378,
-0.0155085,
-0.04130257,
0.0031123862,
0.021145526,
-0.01777934,
0.012456224,
0.0021840136,
-0.039058443,
0.0055835946,
-0.012456224,
-0.014533374,
0.030242244,
0.02294884,
0.020731432,
-0.016617205,
-0.013518176,
-0.0049524345,
0.0011638054,
-0.008175023,
0.0055234837,
0.031230727,
0.01184844,
0.0006599628,
0.005667081,
-0.0068726297,
-0.01898155,
-0.036199857,
0.02994837,
-0.0023276107,
-0.029520918,
0.01777934,
0.0008177528,
-0.005429979,
-0.019088412,
-0.00039405748,
-0.03788295,
-0.028291993,
-0.005984331,
0.0038170146,
-0.00013232652,
-0.00573721,
-0.0052463077,
-0.011127115,
-0.021132167,
-0.01122062,
-0.018567454,
0.020330695,
-0.021759989,
-0.05233618,
0.00054182904,
-0.029146897,
-0.008562402,
-0.021639768,
-0.018767823,
0.005580255,
0.00914347,
-0.013972344,
0.038978297,
0.010659589,
0.008736054,
-0.0022407845,
0.01727174,
-0.021800062,
-0.008869633,
0.005089353,
0.014853964,
-0.009824722,
0.0027083105,
0.008048124,
0.008388749,
-0.014600164,
-0.002868605,
-0.011427667,
0.008655907,
-0.007513808,
0.0089163855,
0.0017949652,
0.018260224,
-0.0011362548,
-0.021412684,
0.022147367,
-0.021265747,
-0.024378134,
-0.009216938,
0.005373208,
0.0031875244,
-0.02767753,
0.0023309502,
-0.03403588,
0.005035921,
-0.04218419,
-0.008629192,
-0.02130582,
0.004067475,
-0.01745875,
0.019970033,
0.010579442,
-0.010165348,
0.007981334,
0.030536117,
-0.026702404,
-0.005466713,
-0.028051551,
0.0047453875,
0.021172242,
-0.010345679,
-0.025019312,
-0.003195873,
-0.020664642,
0.038951583,
0.04739376,
-0.023910608,
0.009764611,
0.011093721,
-0.036734175,
0.014399796,
-0.010038448,
0.021092094,
0.016002743,
0.01185512,
0.0112139415,
0.011120436,
-0.002691613,
0.02489909,
-0.019809738,
-0.0057605864,
0.0074737347,
0.012823566,
0.031444453,
-0.0032509742,
-0.03342142,
-0.008849597,
0.004585093,
0.0005397419,
-0.005149463,
-0.0036934542,
-0.004588432,
0.009564243,
-0.0002715407,
-0.0018316995,
0.022735113,
-0.0060644783,
-0.022401167,
-0.012963824,
-0.008341997,
0.0027750998,
-0.001973627,
-0.025860857,
-0.03323441,
-0.0025613736,
0.010619516,
-0.0110469675,
0.0010794838,
0.015388279,
-0.006979493,
-0.0214394,
0.011447704,
0.0076741027,
-0.032513082,
0.02515289,
0.011400952,
0.00010180166,
-0.00029742156,
-0.0026715763,
-0.028959887,
-0.017752625,
0.0052062343,
-0.007787645,
-0.011294088,
0.0016471937,
0.022548104,
-0.012977182,
-0.010753094,
-0.0068125194,
-0.0029103484,
-0.014092565,
0.022654967,
-0.012095561,
-0.00044623672,
-0.0017448732,
0.014252859,
-0.020464273,
0.006705656,
-0.010873315,
-0.006361691,
-0.02912018,
0.006986172,
-0.02452507,
-0.035825837,
0.019636085,
0.0201704,
-0.0075872764,
0.012462903,
-0.008849597,
0.18818583,
0.0031357626,
-0.036654025,
0.013277734,
-0.027316866,
-0.017231667,
0.027210005,
0.0004249476,
0.010252174,
-0.0011771633,
-0.0090833595,
0.000019867239,
-0.03430304,
0.0043914034,
0.03245965,
-0.02212065,
-0.038363837,
-0.025673848,
-0.017659118,
-0.015054332,
-0.01745875,
-0.0073802294,
0.008642549,
0.006001028,
0.0030372483,
-0.0088763125,
-0.0028352102,
0.010372395,
0.009123432,
0.022494672,
-0.017058015,
0.004578414,
0.01740532,
0.017285097,
-0.009544206,
-0.030429253,
-0.008034766,
-0.020263907,
0.0033044058,
0.022588177,
-0.0063884067,
0.02874616,
-0.011227299,
0.017485466,
-0.035024364,
0.048328813,
0.004281201,
-0.031284157,
-0.013391276,
-0.020290622,
-0.01437308,
0.010526011,
0.024204481,
0.004017383,
-0.021519547,
-0.023843817,
-0.00018836699,
0.018514024,
-0.017204951,
0.02345644,
-0.0012189066,
0.004117567,
-0.0162699,
0.02383046,
-0.0062949015,
0.010966821,
-0.004010704,
0.005112729,
0.0007017062,
-0.041436147,
0.021613052,
-0.029013319,
-0.025794068,
-0.004545019,
-0.010038448,
-0.017124804,
0.021225674,
0.024391491,
-0.014399796,
0.00321591,
0.015054332,
-0.015294774,
-0.011754936,
-0.006084515,
-0.012369398,
-0.03387559,
-0.011173868,
0.00945738,
-0.008175023,
-0.02055778,
0.010786489,
-0.01903498,
-0.019008266,
0.01715152,
0.004568395,
0.010566084,
0.0023459778,
0.030669695,
0.004294559,
0.019395644,
-0.004585093,
0.051695,
0.029333906,
-0.014987542,
-0.010425827,
0.010873315,
-0.0157623,
0.05615653,
0.0014259538,
-0.0054767313,
0.0029203668,
0.020597853,
-0.006952777,
-0.01752554,
0.00023522394,
0.015455069,
0.0033645164,
-0.022307662,
0.0042645037,
0.002554695,
0.006708996,
-0.00060987077,
0.009190222,
0.029975085,
0.002943743,
-0.01645691,
-0.009657748,
0.007079677,
-0.006001028,
-0.033261124,
-0.014199427,
-0.032352787,
-0.0060043675,
0.004615148,
0.0032559836,
0.014279575,
0.005049279,
-0.014947469,
0.016764142,
0.025994437,
0.018674318,
0.00036379354,
0.026769195,
0.03334127,
0.009544206,
-0.033768725,
0.02874616,
-0.017058015,
-0.018433876,
0.0062882225,
-0.013958986,
-0.005049279,
0.026822625,
-0.014586806,
-0.011334162,
-0.0333947,
-0.0066422066,
-0.031925336,
-0.008842917,
-0.0061012125,
-0.026555467,
-0.0049090213,
0.0032643322,
-0.006021065,
-0.009243654,
-0.02269504,
-0.16713381,
0.011975341,
0.020718073,
0.0058407336,
0.029013319,
0.016256541,
0.024992596,
0.027704246,
-0.02011697,
-0.007193219,
0.01713816,
0.007520487,
0.015107764,
0.0007238302,
-0.00053097575,
0.024324702,
-0.013277734,
0.012509656,
0.006972814,
-0.011995377,
0.014145996,
-0.029280476,
0.008769449,
-0.032753523,
-0.0098581165,
0.0015161196,
0.012322646,
0.009804685,
-0.026128016,
-0.011100399,
-0.032058913,
-0.00832196,
0.03387559,
-0.0043279533,
0.011180546,
-0.019115128,
0.01657713,
-0.011955304,
-0.003983988,
0.040367518,
-0.013210945,
0.015187911,
0.011895193,
-0.014586806,
-0.0131775495,
-0.00201871,
-0.009490775,
-0.011127115,
0.02566049,
-0.006739051,
0.010672947,
-0.012075525,
0.0035698938,
0.007927902,
-0.008348675,
0.0060177254,
-0.014386438,
0.030429253,
-0.011868478,
-0.022855334,
0.00081483077,
0.008622512,
0.020958515,
0.018180076,
-0.0004362183,
-0.027891256,
-0.0019235349,
0.0016313313,
-0.03467706,
0.014413154,
-0.013958986,
-0.03486407,
-0.0035465176,
-0.0408484,
0.032486368,
-0.011380915,
-0.012756777,
-0.0012573106,
0.0060811755,
0.021933641,
-0.0059743123,
0.037402067,
-0.033742007,
-0.011955304,
-0.029734643,
0.025059385,
0.022214156,
-0.001343302,
0.019449076,
0.0042077326,
-0.0014267887,
-0.04039423,
0.003259323,
-0.027490519,
0.0028652656,
0.0070997137,
0.0041075484,
-0.023777029,
-0.0020854992,
-0.020878369,
-0.0076741027,
-0.011026931,
-0.005793981,
0.015802374,
0.040127076,
0.015682153,
-0.0055067865,
0.01116051,
0.029627781,
-0.008896349,
0.01954258,
0.013411312,
0.011815046,
0.029414054,
0.0005213748,
0.020023463,
0.004758745,
-0.019916601,
0.008816201,
-0.01822015,
0.034329753,
-0.012629877,
-0.004848911,
0.020370768,
0.01986317,
-0.015655437,
-0.12599154,
-0.007086356,
0.047073174,
0.0048455712,
-0.012589803,
-0.014145996,
-0.0055201445,
0.029467486,
-0.0088763125,
0.025126174,
-0.0032242585,
-0.013070687,
0.0018617547,
0.005426639,
0.04394743,
-0.048943277,
-0.0011629706,
-0.027624099,
-0.022187442,
0.023723597,
-0.028532434,
0.0021389308,
0.010505973,
-0.02459186,
-0.0047687637,
-0.03676089,
-0.024752153,
0.023923965,
0.0060544596,
-0.010138632,
0.023483155,
-0.0028485681,
0.009530848,
-0.0116146775,
-0.032005485,
-0.022374451,
-0.0057472284,
-0.020597853,
0.040527813,
-0.027383657,
-0.0030288997,
-0.0069260616,
0.026114658,
-0.020157043,
0.018059855,
-0.033127546,
-0.0354251,
0.014159354,
-0.009096717,
-0.026074585,
0.0025146212,
-0.015081048,
0.009190222,
0.008368713,
0.001405917,
-0.032860387,
0.0055201445,
-0.018954834,
-0.0006983667,
-0.013090723,
-0.0070195664,
0.017044656,
-0.01513448,
0.017418677,
0.0015595326,
-0.029307192,
-0.012189067,
-0.015548574,
0.0072600082,
-0.016443552,
-0.02086501,
0.0076006344,
0.0029671194,
0.004521643,
-0.03959276,
-0.0019569297,
-0.018500665,
0.0037268489,
-0.008582438,
-0.00850897,
-0.003663399,
-0.009604316,
0.007560561,
-0.012963824,
0.03323441,
0.012917072,
-0.005176179,
-0.010045127,
0.0015303122,
-0.020464273,
-0.00030952715,
0.018807897,
0.006151304,
-0.018754466,
-0.015214627,
0.026782552,
-0.0023726937,
-0.020838294,
0.0039372356,
0.0072533297,
-0.030402537,
-0.0150009,
-0.036921185,
0.0065921145,
0.013852123,
0.013337844,
0.007794324,
-0.017832771,
0.045550376,
0.0070329243,
0.015094406,
0.0025897592,
-0.040768255,
0.0032977269,
-0.029280476,
-0.0019235349,
-0.008789486,
-0.0018550757,
0.023870533,
0.018580813,
0.0127634555,
-0.003145781,
0.0063049197,
-0.0033929017,
-0.004581753,
0.014934111,
0.0037168304,
-0.005075995,
0.0052129133,
-0.0017599008,
0.019008266,
-0.004615148,
0.015989384,
-0.051775146,
0.029360622,
0.00090249185,
-0.014025776,
-0.002982147,
-0.013451386,
0.007273366,
0.0043413113,
0.020771505,
-0.003397911,
-0.038924865,
0.017191593,
-0.011354199,
0.009123432,
0.00039697954,
-0.032352787,
0.020223832,
0.0010352358,
-0.015227985,
0.027210005,
0.0013332835,
-0.018086571,
-0.020010106,
-0.022080578,
0.0026264933,
-0.012910392,
-0.007854434,
-0.0006958621,
-0.019275423,
0.05995017,
-0.014813891,
0.006992851,
-0.0059041837,
0.019662801,
0.0028034854,
-0.01185512,
0.021279104,
0.014292933,
0.017699193,
-0.013558249,
-0.02401747,
0.0063316356,
-0.0059609544,
0.022935482,
-0.03272681,
0.0013132467,
0.013785333,
-0.020464273,
0.018807897,
-0.0022658305,
-0.0044181193,
-0.018233508,
0.0123627195,
0.022107294,
-0.0013157513,
-0.0024645291,
0.0046852767,
-0.0010043457,
0.010472579,
-0.038470697,
0.004311256,
-0.0076874606,
0.027891256,
-0.006458536,
0.016082888,
0.00933048,
-0.0077074976,
-0.009477417,
0.01077981,
-0.0016622214,
0.0057104942,
-0.020464273,
0.006458536,
-0.006147965,
-0.010412469,
-0.0031992125,
-0.054259714,
-0.008188381,
0.007280045,
-0.015748942,
0.008415465,
-0.0031875244,
0.014947469,
0.010759774,
-0.0060577993,
-0.010192064,
-0.020517705,
-0.0033828835,
0.011153831,
-0.01437308,
0.022654967,
0.0019886545,
-0.000034751363,
0.01184844,
-0.014720385,
0.040688105,
-0.00951749,
0.048756268,
0.0079212235,
0.016737426,
-0.0071063926,
-0.012108919,
-0.023549944,
0.014546732,
0.0017849469,
0.0005643705,
0.025393331,
0.015748942,
0.060805075,
0.007734213,
-0.03323441,
-0.010579442,
-0.009130112,
0.024618575,
0.00977129,
-0.010579442,
0.01740532,
-0.014199427,
0.03392902,
0.0008933083,
0.020290622,
0.0059676333,
-0.00069460983,
0.0052229315,
0.0057104942,
0.016069531,
0.008549044,
0.010546047,
0.00844886,
-0.0035799122,
-0.0053498317,
0.019809738,
-0.034009166,
-0.025941005,
0.034329753,
0.0049858293,
0.022160726,
-0.023643449,
0.00048464062,
0.022454599,
-0.045416795,
-0.016510341,
-0.008368713,
0.009096717,
-0.04867612,
0.0025630435,
0.000513861,
0.021826778,
0.0031942034,
0.012442866,
-0.023336219,
0.0029938351,
-0.023777029,
-0.02005018,
0.019569296,
-0.010733058,
-0.02276183
] |
A newly emerging family of phosphatases that are members of the haloacid dehalogenase superfamily contains the catalytic motif DXDX(T/V). A member of this DXDX(T/V) phosphatase family known as Dullard was recently shown to be a potential regulator of neural tube development in Xenopus [Satow R, Chan TC, Asashima M (2002) Biochem Biophys Res Commun 295:85-91]. Herein, we demonstrate that human Dullard and the yeast protein Nem1p perform similar functions in mammalian cells and yeast cells, respectively. In addition to similarity in | [
-0.0024909747,
-0.016385078,
0.021477738,
-0.026999399,
-0.023193743,
0.040409148,
-0.0153748505,
-0.0076805055,
-0.017948857,
-0.011368533,
0.028369436,
-0.0036811072,
0.021491578,
0.036866426,
-0.026639592,
0.0005410086,
0.026764141,
-0.027414562,
-0.0035029333,
0.00829633,
-0.010987966,
0.0042554154,
-0.0027487215,
-0.0049058367,
-0.02212816,
0.015845368,
0.020827318,
-0.024536101,
-0.016910952,
0.005497443,
0.0015931859,
-0.014115524,
0.026210591,
-0.026639592,
0.015665464,
-0.011645307,
0.002610334,
-0.0068501807,
0.014281589,
-0.008033394,
0.0065111313,
-0.0013449534,
-0.0097217215,
-0.021726836,
-0.0079642,
0.0057915165,
0.0015698331,
-0.025587847,
-0.012870036,
0.020550542,
0.011410048,
0.023304453,
-0.009161252,
0.0050407643,
-0.020882672,
-0.007293021,
0.02333213,
0.007978039,
-0.016205175,
-0.015084236,
-0.017077016,
0.006452317,
-0.0032261584,
0.02334597,
0.01659266,
0.009943141,
-0.009140493,
0.00023936712,
0.0008917344,
-0.00019395871,
0.03783514,
0.006061372,
-0.0034216307,
-0.011112516,
0.030998798,
-0.0128285205,
-0.022404935,
-0.0012705701,
0.006016396,
0.004808965,
0.012309567,
-0.024826715,
-0.006822503,
0.027262336,
0.034901325,
0.011008725,
-0.011811372,
0.0052172085,
-0.006151324,
-0.012295729,
0.02908905,
0.04281709,
0.030251505,
0.021823708,
-0.026944045,
0.005013087,
-0.011472323,
0.026265945,
0.0017099504,
-0.02986402,
-0.023982553,
0.011133273,
0.0065837847,
-0.018530086,
-0.012018953,
-0.00043397452,
-0.011437726,
-0.00090989773,
0.02388568,
-0.00199105,
-0.011998195,
0.0404645,
0.011015644,
-0.044726837,
0.021948256,
-0.019208184,
0.022930807,
0.0020550543,
-0.000100925565,
0.009438027,
0.013686523,
0.037890494,
-0.00884988,
-0.015651625,
0.03916366,
0.021339351,
-0.008019555,
0.0050580627,
-0.0009358454,
-0.008953671,
0.02023225,
0.015015042,
0.019443443,
-0.0043972624,
-0.03692178,
0.009002106,
-0.01825331,
-0.008227136,
-0.0097217215,
-0.026335139,
0.00873917,
0.008192539,
-0.02421781,
-0.017851986,
0.0034268203,
0.014281589,
0.023249099,
0.0127454875,
0.013790313,
0.0055147414,
0.025947655,
-0.012662455,
0.015942238,
-0.012268051,
0.00309815,
0.012524067,
-0.0013648466,
0.013748797,
-0.00025320586,
-0.0014124173,
-0.022875452,
-0.010406739,
-0.012738569,
-0.020273767,
0.011465403,
0.02831408,
0.008753009,
-0.008171781,
-0.011375451,
-0.036451265,
-0.012973827,
0.017616728,
-0.03282551,
0.018765343,
-0.029891698,
0.0028957583,
0.010711192,
-0.0016987064,
-0.02511733,
0.010296029,
-0.0010655837,
0.012371842,
0.031663056,
0.018045729,
0.011555355,
0.008780686,
0.026099881,
-0.006061372,
-0.002897488,
-0.018433213,
0.0019322353,
0.01714621,
-0.01670337,
-0.010780386,
-0.642118,
-0.028397113,
0.0065976237,
-0.015554754,
-0.01172834,
0.017270759,
-0.0016277828,
-0.016288208,
-0.01626053,
0.00553204,
-0.010192239,
0.010614321,
-0.0053936522,
-0.016648015,
-0.030002408,
-0.026376655,
0.0048885383,
-0.008434718,
0.03539952,
0.0141432015,
-0.008593863,
0.008524669,
-0.023816487,
-0.001305167,
0.020882672,
0.011700662,
0.008932913,
-0.015499399,
0.004006318,
0.020633575,
-0.013541216,
0.019180506,
-0.016883275,
0.024245488,
0.050511435,
0.009126655,
0.008490073,
0.017976535,
0.01659266,
0.028009627,
-0.00961793,
0.0060129366,
0.017935019,
-0.0012100256,
-0.030805055,
0.013299038,
0.008898316,
0.008538508,
0.004002858,
-0.005549338,
-0.015457883,
-0.0029960892,
-0.0019166667,
0.010469014,
0.0045287306,
0.006625301,
0.026362816,
-0.03332371,
0.001691787,
0.012849279,
-0.0074729244,
0.019000603,
0.006601083,
-0.006870939,
-0.0109810475,
0.023761133,
-0.0026172535,
0.010192239,
-0.011901324,
0.009223526,
-0.008891396,
0.022211192,
0.011534597,
0.017741276,
-0.0076459087,
0.027303852,
0.017658243,
0.01648195,
0.016232852,
0.014793622,
-0.008704573,
-0.0068432614,
-0.022986162,
0.00028455927,
0.034126356,
0.012890794,
-0.016869435,
0.023484357,
0.018128762,
0.004597924,
0.018876053,
-0.0088291215,
-0.015790012,
-0.035537906,
-0.019111313,
0.03905295,
-0.019623347,
-0.011070999,
0.019664863,
-0.025158845,
-0.014738267,
-0.004431859,
0.007666667,
-0.018530086,
0.028037306,
0.0024702167,
-0.016205175,
0.012012034,
0.037973527,
-0.027027076,
-0.0046705776,
-0.016537305,
-0.03260409,
-0.008988268,
0.00032412945,
-0.02421781,
0.024978941,
0.010877256,
0.0011546706,
-0.015305656,
0.0054663057,
-0.005552798,
0.010261432,
-0.01139621,
0.012309567,
0.022916969,
-0.011112516,
-0.010655837,
0.0021796029,
0.010157642,
-0.008925993,
0.0029009478,
0.025698557,
-0.031829122,
0.007126956,
0.035787005,
0.0014868006,
-0.0046221423,
0.011472323,
-0.009320398,
-0.009811673,
-0.026404332,
-0.00995698,
-0.010296029,
-0.01250331,
-0.013478941,
-0.017090855,
0.0028127257,
-0.01504272,
-0.00018822862,
0.009541817,
0.022944646,
-0.021090254,
0.006185921,
-0.013928701,
-0.0023941037,
-0.022529483,
-0.012081228,
-0.008919073,
-0.008088749,
0.00093930506,
0.011354693,
-0.015693141,
-0.0196787,
0.0027452619,
-0.035897713,
0.025753912,
0.009015945,
-0.0019668322,
-0.02290313,
0.01183905,
-0.0030479846,
-0.0039025273,
0.0034752558,
-0.0013172759,
0.035787005,
0.002565358,
-0.0018526625,
0.012178099,
-0.007147714,
0.009790915,
-0.021712998,
-0.013541216,
-0.0019478039,
0.03133093,
0.013977136,
0.028452467,
0.014558364,
-0.0004878159,
0.037115525,
-0.015651625,
-0.0016987064,
-0.010676594,
0.008676896,
0.0012005115,
-0.013153731,
0.036257524,
0.001471232,
-0.02223887,
0.015167269,
0.0051826113,
-0.030223828,
0.018848376,
0.002899218,
0.00032607553,
-0.024079423,
-0.0013285199,
-0.0011399669,
0.014586042,
0.021270158,
-0.021311674,
-0.016910952,
-0.010109206,
-0.0047259326,
-0.015305656,
0.005708484,
-0.00519991,
-0.010884176,
-0.016841758,
-0.015540915,
0.008227136,
-0.023733454,
0.021367028,
0.022252709,
0.0047812876,
0.0025601685,
-0.0064315586,
0.040353794,
-0.022432612,
0.0017073556,
0.0005496578,
0.017602889,
-0.012371842,
0.013520458,
-0.0054490073,
0.017506018,
0.009915464,
-0.011790614,
0.02798195,
-0.0021796029,
-0.008946751,
0.005805355,
-0.010219916,
0.00070101913,
-0.002278204,
-0.00040089127,
0.028922986,
-0.009092058,
-0.0058122748,
0.013015344,
-0.0038575514,
0.027414562,
-0.02024609,
-0.012344164,
0.008240975,
-0.009334236,
-0.0010223376,
0.003041065,
0.03869314,
0.0020498647,
0.003771059,
0.01659266,
0.002778129,
-0.00029991163,
0.0045218114,
0.0025567089,
0.009680205,
-0.017755115,
-0.014129363,
-0.0048885383,
-0.005961041,
0.0009721721,
0.005020006,
-0.03263177,
0.0065318896,
0.010801144,
-0.010475933,
0.0075836345,
0.005950662,
0.0051722326,
-0.027027076,
-0.047605295,
0.031884477,
0.027968112,
-0.02986402,
-0.019055957,
-0.028673887,
-0.0019616426,
0.031939834,
0.018280987,
0.00005232777,
0.0029736012,
-0.0055182013,
0.01947112,
-0.024425391,
-0.007978039,
0.009687124,
-0.020938028,
0.011520758,
-0.0020377557,
0.0026726085,
-0.0028611613,
-0.017782792,
-0.022612516,
0.03808424,
0.0010543397,
-0.008123346,
-0.012046631,
0.0114308065,
-0.03786282,
0.0008705438,
-0.0031275572,
0.016551144,
-0.011797533,
-0.02279242,
-0.0036430506,
-0.007722022,
0.010455174,
0.021629965,
-0.009147413,
-0.010337546,
-0.017243082,
-0.001361387,
-0.001770495,
0.018114923,
0.033157643,
-0.008199459,
0.007874249,
0.0048885383,
0.0043730447,
-0.012953069,
-0.008580024,
0.041211795,
0.009860109,
-0.013216006,
-0.004438779,
0.007182311,
0.008621541,
0.004656739,
0.013305957,
0.00029428964,
0.0014106875,
-0.002854242,
0.011299338,
0.0057811374,
0.0027175844,
0.015084236,
0.03285319,
0.037226234,
0.0137142,
0.025532492,
0.00453565,
0.022183515,
-0.0061444044,
-0.008510831,
0.0024183213,
-0.0018837997,
0.027137786,
-0.014253912,
-0.016717209,
-0.005815734,
0.031386282,
0.010496691,
0.014544525,
0.0049473527,
0.009431107,
-0.0025255717,
0.004113568,
0.011375451,
-0.016288208,
-0.006891697,
0.009133575,
-0.016648015,
-0.03672804,
0.027123949,
-0.031358603,
0.0122403735,
-0.026598075,
0.014240073,
-0.0049058367,
0.022432612,
-0.0076182312,
-0.014323105,
-0.014530687,
0.007452166,
-0.004279633,
0.012870036,
0.0050892,
-0.0064799944,
0.02223887,
-0.0062205177,
-0.01603911,
-0.015886884,
-0.0010110936,
0.0030047384,
-0.0112855,
-0.038001206,
-0.012441035,
0.0034700662,
0.029836344,
0.0133889895,
-0.021021059,
0.018959086,
0.014544525,
-0.024051746,
0.0159284,
-0.0007498872,
-0.020771962,
-0.0052483454,
0.018225633,
0.007403731,
-0.038803853,
-0.0089121545,
-0.010046932,
0.02711011,
-0.008088749,
-0.0033126506,
0.005850331,
-0.00035029333,
0.011292419,
0.042042118,
0.041433215,
-0.005030385,
0.007895006,
-0.029282793,
-0.04016005,
-0.011659146,
-0.0122403735,
0.007500602,
-0.020273767,
0.0055182013,
0.011776775,
0.011576113,
-0.038222626,
0.004224278,
0.000735616,
-0.007777377,
0.0018163358,
0.003253836,
0.012807762,
0.005594314,
0.005895307,
-0.022764742,
0.003175993,
-0.0007836192,
0.0032054002,
0.034347776,
-0.0031362064,
-0.040187728,
0.023871843,
0.01626053,
-0.043536704,
0.0010534747,
0.0109810475,
0.015250301,
0.020481348,
-0.007811974,
-0.021339351,
-0.014655235,
0.000669017,
-0.0108703375,
0.0031915614,
-0.010434417,
-0.033212997,
-0.001504099,
0.009451865,
0.01426775,
-0.008524669,
0.0021432762,
-0.037973527,
-0.01902828,
-0.00420352,
0.015471721,
0.014281589,
-0.028120337,
-0.014433815,
-0.0072653433,
-0.034901325,
-0.02046751,
-0.028812276,
0.009714802,
-0.0011339125,
0.013679603,
-0.007244585,
0.047079425,
-0.014184718,
0.003826414,
0.026999399,
0.006760229,
-0.0031154484,
-0.0045633274,
0.00741065,
-0.0153748505,
0.03584236,
0.023705777,
-0.011956679,
0.01803189,
-0.013229844,
0.017422985,
0.014655235,
-0.0034164411,
-0.029448858,
0.008081829,
-0.047300845,
-0.019775573,
-0.0030445247,
-0.022847775,
-0.018959086,
-0.024411554,
-0.011686823,
0.026238268,
0.009825512,
0.00024434042,
-0.006704874,
0.019858604,
-0.009673285,
0.021228641,
0.008503911,
0.034984358,
-0.00686056,
-0.007334537,
0.008261733,
-0.006922834,
0.022723226,
0.0049404334,
0.006926294,
0.021602288,
-0.004172383,
-0.008109507,
0.013105296,
-0.002719314,
-0.018018052,
-0.025629364,
-0.022958485,
-0.025947655,
-0.026127558,
-0.014240073,
-0.046083033,
0.0005111688,
0.006448857,
-0.024702167,
0.020910349,
-0.005763839,
-0.021851385,
0.031109508,
-0.001415877,
0.03030686,
-0.035233457,
0.024978941,
0.02919976,
0.007334537,
-0.031939834,
-0.020619735,
0.00862846,
-0.00918201,
0.035676293,
0.0049715703,
-0.0069089956,
-0.029144404,
0.0079642,
-0.0016857326,
-0.0140878465,
-0.014018653,
0.004542569,
-0.02454994,
0.010406739,
0.0073137786,
-0.00007789702,
0.004556408,
0.015015042,
-0.00036348338,
0.0037433817,
-0.017422985,
0.0063554454,
-0.009431107,
-0.020550542,
-0.0057845972,
0.025684718,
0.02312455,
0.009590253,
0.021796029,
-0.025020458,
-0.01637124,
0.010012335,
0.005829573,
0.01836402,
-0.017492179,
0.026542721,
-0.0027400723,
0.01904212,
0.0069643506,
0.003905987,
-0.010206077,
0.0351781,
-0.007033544,
0.00697127,
0.026307462,
0.0046844166,
0.0065803253,
-0.022100482,
-0.0033126506,
-0.018225633,
-0.038388688,
0.005334838,
0.03332371,
-0.008088749,
-0.0024373496,
0.013672684,
-0.02886763,
0.0009479543,
-0.017298436,
-0.018557763,
0.01504272,
-0.055161253,
-0.022750903,
0.0015291817,
0.02720698,
0.016855596,
-0.0044560772,
-0.0012800843,
-0.0017748196,
0.02223887,
0.00034337395,
0.005341757,
-0.001151211,
0.008240975,
-0.033821903,
-0.006428099,
0.008109507,
-0.039191335,
0.020329122,
-0.052670278,
-0.010801144,
-0.009348075,
-0.006030235,
0.017243082,
-0.008836041,
-0.011956679,
0.007026625,
0.0064004213,
0.02499278,
0.005705024,
-0.021560771,
0.0076874252,
-0.016523466,
-0.0028438629,
-0.0056842663,
0.00962485,
-0.008144104,
0.009908544,
-0.029836344,
-0.01956799,
-0.020785801,
-0.011375451,
-0.020384477,
-0.0055251205,
0.016412755,
-0.011091758,
-0.0035703972,
0.008061071,
0.0015698331,
0.0115691945,
-0.00089346425,
-0.02344284,
0.006296631,
-0.018530086,
-0.0054040314,
0.0022955025,
-0.021367028,
-0.02212816,
0.025933815,
-0.040132374,
-0.015499399,
0.010572804,
-0.025366427,
0.019941637,
0.00012335947,
-0.016025271,
-0.0018163358,
0.0036049942,
-0.03174609,
-0.0073829726,
-0.009313478,
0.0052621844,
0.021782191,
-0.0030618233,
-0.005794976,
0.019996991,
-0.021782191,
0.007389892,
0.004954272,
-0.013990975,
0.018723827,
-0.01515343,
0.028618533,
-0.012766246,
-0.02068893,
-0.00001878502,
0.020965705,
-0.011562275,
-0.014918172,
0.02277858,
-0.017893502,
-0.0060786703,
-0.027954273,
0.01437846,
0.006933213,
0.020190734,
0.0065664863,
-0.0062135984,
-0.028369436,
-0.020453671,
0.007562876,
-0.0075836345,
0.005698105,
0.0016554603,
-0.011313178,
-0.0020291065,
-0.006151324,
-0.011645307,
0.0121019855,
0.000012838683,
0.015167269,
0.013271361,
0.005068442,
-0.00066555734,
0.018848376,
-0.010994886,
-0.017243082,
-0.0090713,
-0.03174609,
-0.0049715703,
0.0116245495,
0.0066356803,
0.0013821451,
-0.015762335,
-0.011873647,
-0.046858005,
-0.0054178704,
-0.012648617,
0.0010188778,
-0.018737666,
0.037696753,
0.00001675786,
-0.0016736237,
-0.019886281,
0.0050995788,
0.0068743983,
-0.00094622443,
0.009770157,
0.020149218,
-0.004767449,
0.0024044826,
0.011534597,
-0.01803189,
-0.01870999,
0.0063658245,
-0.027594466,
0.0005440358,
0.019388087,
0.19352107,
0.015015042,
0.005452467,
0.014364622,
0.019734057,
0.021740675,
0.015319495,
-0.0102821905,
-0.009064381,
-0.014419977,
0.027068593,
0.0070197056,
-0.023415163,
0.0049300543,
0.012406439,
0.002036026,
-0.01902828,
-0.018073406,
-0.0050165467,
-0.0040755114,
0.01361041,
-0.014150121,
-0.00052889966,
-0.0008826527,
0.054164864,
-0.0077358605,
-0.020730445,
0.0016554603,
-0.0077912156,
0.012946149,
-0.017616728,
-0.021989772,
0.0023093412,
0.010579724,
0.008524669,
-0.004580626,
-0.0060579125,
-0.014011733,
-0.008130265,
0.023401324,
0.011520758,
-0.009348075,
-0.013077618,
-0.019305054,
-0.026321301,
0.01848857,
0.0033161102,
-0.00093930506,
0.0089675095,
-0.00674639,
-0.05341757,
0.028189532,
0.026487365,
0.009009026,
-0.021131769,
-0.02255716,
-0.014987365,
0.016620338,
-0.00014163095,
0.039744888,
-0.0012774895,
0.010628159,
-0.03376655,
0.026791818,
-0.015776174,
0.014765945,
-0.032908544,
-0.015222624,
0.028950663,
-0.028590856,
-0.0027729394,
-0.009998496,
-0.014503009,
0.0060094767,
-0.017948857,
-0.014281589,
0.006625301,
0.028231047,
0.026169075,
0.038886886,
-0.007244585,
0.012115825,
-0.03229964,
-0.012288809,
-0.0020204573,
-0.034015644,
0.03141396,
0.0011797533,
-0.030915765,
-0.013797233,
0.0042554154,
-0.015444044,
-0.022211192,
0.02255716,
0.006981649,
-0.0018422834,
0.011327016,
0.0034250903,
0.00873917,
-0.014212395,
-0.014184718,
0.04082431,
0.0026829874,
0.035233457,
-0.02931047,
0.016523466,
-0.0019287757,
0.026667269,
0.011147113,
-0.01150692,
0.008586944,
-0.022584839,
-0.002343938,
-0.0055216607,
0.0008216757,
0.01823947,
0.011444645,
-0.026736462,
0.026099881,
-0.011140193,
0.017990373,
-0.033877257,
-0.007092359,
0.047716007,
-0.0046325214,
-0.01416396,
-0.035897713,
-0.0035202317,
-0.021270158,
-0.02344284,
-0.0040201563,
-0.008358604,
0.0041966005,
0.012198857,
-0.0140048135,
0.00353926,
0.016772565,
-0.0051929904,
0.0007334537,
0.009444946,
-0.016523466,
-0.0064211795,
0.021948256,
0.012226535,
-0.017741276,
-0.046387486,
0.015956078,
0.015914561,
-0.0010699083,
-0.023249099,
-0.021007221,
-0.009700963,
0.0030687426,
-0.010462094,
0.008310169,
-0.025809268,
-0.01216426,
-0.022709386,
0.007348376,
-0.005109958,
-0.023581227,
-0.00034640118,
0.02975331,
-0.028258726,
0.0022107402,
0.0026397414,
-0.17791095,
0.010185319,
0.0007814569,
-0.03420939,
0.01956799,
0.021754513,
0.029891698,
0.0027123948,
-0.020495187,
0.016897112,
0.016066788,
0.016025271,
-0.051120337,
-0.03927437,
-0.0048297234,
0.0045183515,
-0.016606499,
0.013202166,
0.014170879,
-0.00005773353,
0.0365343,
-0.015886884,
0.0014677723,
0.013202166,
0.00950722,
0.038637787,
0.018640796,
-0.00005435493,
-0.001704761,
-0.026902528,
-0.007860409,
0.012012034,
0.033434417,
-0.0019754814,
0.018862214,
0.002819645,
0.015319495,
-0.011998195,
-0.0026483906,
0.017907342,
-0.0014989096,
0.01956799,
0.015125752,
-0.020675091,
0.027566789,
0.03282551,
-0.029504213,
-0.020744285,
0.01870999,
-0.022391096,
0.042291217,
-0.020066187,
0.03717088,
0.024065584,
0.029891698,
0.0072584236,
0.0046256017,
0.012288809,
-0.007068141,
-0.0028161854,
0.012489471,
0.007929604,
0.0060025575,
0.029061373,
-0.003087771,
-0.035427198,
-0.020370638,
-0.008856799,
-0.03830566,
0.0019460741,
-0.016993985,
-0.012835439,
-0.011008725,
-0.017492179,
0.018184116,
0.0068536405,
-0.022515645,
-0.008669976,
-0.012115825,
0.011230145,
-0.006130566,
0.015194946,
-0.029144404,
-0.021159448,
0.008344766,
0.025919978,
-0.0058468715,
0.02268171,
-0.002864621,
-0.0027418023,
0.014336944,
-0.021436222,
0.010545127,
-0.007611312,
0.01969254,
0.03329603,
-0.013409748,
-0.0014037681,
-0.004580626,
0.0072653433,
0.0073829726,
-0.0025567089,
-0.023373647,
0.026141398,
0.022487966,
0.012856198,
-0.0024857852,
0.0075905537,
0.033683516,
-0.013382071,
0.0078188935,
0.002676068,
0.02312455,
0.022391096,
0.0012930582,
0.025490975,
0.0009790915,
-0.00029147865,
-0.0077151028,
-0.019305054,
0.05294705,
0.0012818141,
0.0050027077,
-0.00070058665,
0.009479543,
-0.032936223,
-0.11447413,
-0.0034043323,
-0.011202468,
0.011825211,
-0.0061582434,
0.0047847475,
0.011209386,
0.030805055,
-0.007888087,
0.034486163,
-0.01913899,
-0.017616728,
0.014475332,
-0.012551745,
0.021962095,
0.004023616,
0.020370638,
-0.017533695,
-0.021602288,
0.04558484,
-0.0017315735,
0.020827318,
-0.0021519253,
-0.012593262,
0.0006603678,
0.004345367,
-0.02234958,
0.017838147,
0.012233454,
0.0028819195,
-0.0025964952,
-0.00083594694,
0.01603911,
0.002721044,
-0.03473526,
-0.020287607,
0.014336944,
-0.013783394,
0.03163538,
-0.007348376,
0.006282792,
-0.0076874252,
0.025574008,
0.012648617,
0.02443923,
-0.03288087,
-0.0016563253,
0.011493081,
0.010005415,
-0.004919675,
-0.03503971,
-0.019484958,
-0.025823105,
-0.024868231,
0.01393562,
-0.046830326,
0.005500903,
0.030860411,
-0.027386883,
-0.013901023,
-0.01404633,
-0.0008476234,
-0.009873947,
0.015070397,
0.03243803,
-0.002011808,
-0.0020948406,
-0.043204576,
0.0066979546,
-0.051064983,
-0.009223526,
0.024300843,
-0.020149218,
0.002665689,
-0.010385981,
0.022737065,
-0.017658243,
-0.006594164,
-0.008330927,
-0.017298436,
-0.027594466,
-0.019069796,
-0.008033394,
-0.020218411,
0.014765945,
0.005075361,
0.007445247,
0.007500602,
0.035565585,
-0.042983156,
-0.013520458,
0.022640193,
0.0042519555,
-0.00024693517,
-0.010856499,
0.034237064,
0.0022816637,
-0.00951414,
0.005186071,
0.023968713,
-0.033572804,
-0.02809266,
-0.06061372,
0.028272564,
-0.00020509458,
0.0023646962,
0.005926444,
-0.0102821905,
-0.001018013,
-0.0011088297,
-0.014807462,
0.0019633726,
-0.02079964,
0.0019149369,
-0.011403129,
-0.024826715,
-0.027635982,
-0.0070300843,
0.04212515,
-0.018834537,
-0.0026726085,
0.025574008,
0.014876655,
-0.015194946,
-0.0005094389,
0.025933815,
-0.010704272,
-0.0060648317,
-0.03221661,
-0.0025722776,
0.0056842663,
0.022695549,
0.0029234358,
-0.04170999,
0.013437425,
0.015679302,
-0.0077358605,
-0.009873947,
-0.019401927,
-0.005995638,
0.018114923,
0.024494587,
-0.013326716,
-0.036894105,
0.0038713901,
-0.016108304,
0.0019599127,
-0.015900722,
-0.012247293,
0.001150346,
0.014530687,
0.0010915314,
0.025421781,
-0.010212997,
0.0011114245,
-0.029116727,
-0.016066788,
-0.022723226,
-0.0066391397,
-0.014309267,
0.0010136884,
-0.004822804,
0.026293622,
0.015056559,
0.043619737,
-0.009576415,
-0.0041550845,
-0.00015882126,
-0.0032607552,
-0.0022885832,
-0.0112855,
-0.037890494,
-0.022529483,
-0.0050373045,
0.013250602,
0.028480146,
-0.0018976384,
-0.016578821,
-0.014025572,
-0.013748797,
-0.024840554,
0.013769555,
0.021588448,
0.016398918,
-0.02323526,
0.015720818,
0.029919375,
-0.0030341458,
-0.0070716008,
0.010939531,
0.0051410953,
0.020204574,
0.0074175694,
0.024314681,
0.010884176,
0.0017782792,
-0.013063779,
0.0015222623,
0.0022055507,
-0.015388689,
0.015623948,
0.023041517,
-0.027414562,
0.016786402,
0.01603911,
-0.011403129,
-0.009237365,
0.020993382,
-0.051563177,
-0.0062689534,
0.012870036,
-0.02499278,
0.01823947,
-0.016011432,
-0.0011529408,
0.0121573405,
-0.007223827,
0.011029483,
-0.0048331833,
-0.005611613,
0.0015421556,
0.031469315,
0.007860409,
0.012780084,
0.015015042,
-0.005231047,
0.021353189,
-0.0018855295,
0.024632974,
-0.005334838,
0.043592058,
-0.015319495,
0.004078971,
0.005054603,
-0.022861613,
-0.018543923,
0.0051618535,
-0.006459236,
-0.0027366127,
0.01360349,
-0.016135981,
0.085855596,
0.014765945,
-0.027497593,
0.0023387487,
-0.009707882,
0.002191712,
0.012095067,
0.0050719017,
-0.000271153,
-0.014682912,
0.02266787,
-0.024799038,
0.023262937,
-0.017422985,
-0.020619735,
0.021588448,
-0.016551144,
-0.008317088,
0.008663056,
-0.023858003,
0.008649218,
-0.012953069,
-0.0050373045,
0.015693141,
-0.020107701,
-0.010794224,
0.028161854,
0.015250301,
-0.011583033,
-0.021380868,
0.020176897,
-0.007023165,
-0.03420939,
-0.01769976,
0.011756017,
-0.0032797835,
-0.005431709,
-0.008483153,
0.0046256017,
0.014945849,
-0.0011235335,
0.0018872594,
0.0025030838,
-0.015831528,
0.010849579,
-0.020176897,
0.0027919677,
0.011714501,
0.00025580064
] |
Endometriosis is an estrogen-dependent disease affecting up to 10% of all premenopausal women. There is evidence that different endometriosis sites show distinct local estrogen concentration, which, in turn, might be due to a unique local estrogen metabolism. We aimed to investigate whether there was a site-specific regulation of selected enzymes responsible for the oxidative metabolism of estrogens in biopsy samples and endometrial and endometriotic stromal cells. Cytochrome P450 (CYP) 1A1 and CYP1B1 mRNA and protein expressions in deep-infiltrating (rectal, retoss | [
-0.027950667,
-0.029439628,
0.0076276585,
-0.037171774,
-0.027950667,
0.009083967,
-0.03440283,
-0.0041730083,
-0.030510634,
-0.0027036392,
0.026030691,
0.0066807317,
-0.015686331,
0.004535453,
-0.018820986,
0.029309018,
0.043336596,
0.024332752,
-0.0027199655,
-0.003255469,
-0.022412777,
0.016809583,
-0.011990053,
0.002207319,
0.010122321,
0.017854467,
0.010246401,
-0.043258227,
-0.0017763041,
-0.020923818,
-0.0007081543,
0.006168085,
-0.028812697,
-0.008156631,
0.0032766932,
-0.0076145977,
0.015007157,
0.0024636423,
-0.000021185957,
-0.014171249,
0.018481398,
-0.00616482,
-0.0018905883,
0.010403134,
0.0016114082,
0.006429306,
0.002318338,
-0.006128902,
-0.0031966942,
0.021185039,
0.0036179135,
0.01085374,
-0.005475849,
0.003761585,
-0.025991509,
0.006390123,
-0.002145279,
0.013198201,
-0.0003606077,
0.00036489335,
-0.01665285,
-0.002176299,
-0.033984877,
0.0063313483,
-0.0008873357,
0.015072462,
0.0025354782,
0.018076506,
0.009632532,
0.009194986,
0.043179862,
0.013387586,
-0.018546704,
-0.003709341,
0.00899254,
-0.035343226,
-0.029413505,
-0.013505136,
0.010990881,
0.010951698,
0.031999595,
-0.011709239,
-0.013857784,
0.041847635,
0.007823574,
-0.010501091,
0.00061591057,
0.011441488,
0.023745006,
0.0031215933,
0.01368799,
0.014745936,
0.02331399,
0.021851152,
-0.014471654,
0.018729558,
-0.008215406,
0.036779944,
-0.001843242,
-0.031738374,
0.00040550507,
0.031372663,
-0.010148443,
-0.025691103,
-0.03787707,
0.009273352,
0.0025958854,
-0.0002795883,
0.026396401,
0.0033338354,
-0.014536959,
0.027140882,
0.0073272544,
-0.016012859,
0.020793207,
0.0045028003,
0.015137767,
0.0018693641,
-0.028420866,
-0.0013150855,
-0.004796674,
0.01761937,
0.018063445,
-0.030249413,
0.02331399,
-0.0029240446,
-0.020440558,
0.001334677,
0.00789541,
-0.0024146633,
0.005645643,
-0.0004559126,
0.0065044076,
0.005704418,
-0.037406873,
0.0039150524,
-0.024515608,
-0.0083003035,
-0.01763243,
-0.040881116,
0.006461959,
0.028525352,
-0.023849495,
-0.0044701477,
-0.022282166,
0.016613668,
0.016927132,
0.00206528,
0.012564739,
0.00610278,
-0.0068962392,
-0.0094627375,
0.011879033,
-0.021263404,
0.02036219,
0.012473311,
0.017854467,
0.00937131,
-0.02514254,
-0.020192398,
0.01184638,
-0.02514254,
0.014288799,
0.0043721898,
0.015581843,
0.014445531,
0.009639062,
0.00039366848,
0.0052864635,
-0.026043752,
0.003709341,
-0.008894581,
-0.027611079,
0.029570239,
0.014967974,
0.0083460165,
-0.03549996,
0.013354933,
-0.010638232,
-0.026579255,
-0.023209503,
0.006870117,
0.006311757,
-0.014967974,
-0.0251556,
0.009090497,
0.0055085015,
0.014732875,
-0.003402406,
-0.017658552,
-0.008777032,
0.03351468,
0.0032832238,
-0.0067133843,
-0.64532083,
-0.026566194,
0.008914173,
-0.0095541645,
-0.009528043,
0.022373594,
0.0022220127,
-0.0048521836,
0.009390902,
0.008894581,
-0.01923894,
0.014928791,
-0.008581116,
-0.010292115,
-0.0017469167,
-0.025873959,
-0.03134654,
-0.00014571245,
-0.00064040005,
-0.017958956,
-0.027558835,
-0.003637505,
-0.031790618,
0.028708208,
0.021132793,
0.019043025,
0.026801294,
-0.027689446,
0.005397483,
0.022634815,
0.0020946674,
0.045295753,
-0.02553437,
-0.0029175142,
0.04289252,
-0.011578629,
-0.014040639,
0.02886494,
0.012603922,
0.04378067,
-0.0013583502,
-0.017567124,
0.018220177,
-0.00061142084,
-0.0022024212,
0.015555722,
0.020989122,
-0.001652224,
0.016352447,
-0.0029811868,
-0.0030905732,
0.0009118252,
-0.0024571118,
-0.00406852,
0.021302588,
0.015464294,
0.02467234,
-0.028786575,
0.0022367064,
0.010298645,
0.02134177,
0.030040435,
-0.011852912,
-0.024202142,
-0.021407075,
0.0111149615,
-0.025795592,
0.0021550748,
-0.022360533,
0.011448018,
0.0037811766,
0.015346745,
0.016574483,
-0.014602264,
0.026931904,
0.04816919,
0.035055883,
0.016927132,
-0.020074848,
0.0011975359,
0.013465952,
0.011474141,
-0.03539547,
-0.008679074,
0.03513425,
-0.0019199757,
-0.005338708,
0.010037424,
0.0012930449,
0.0082545895,
0.015242256,
0.0019036494,
-0.0076145977,
-0.034481198,
-0.016809583,
0.015581843,
0.004055459,
0.011245572,
0.0278723,
-0.003343631,
-0.021132793,
-0.0032179186,
-0.003970562,
0.013557379,
0.013413708,
0.007882349,
-0.050337322,
-0.0017028356,
0.030745734,
-0.020701779,
0.008907642,
-0.013596563,
-0.019878931,
-0.02109361,
-0.027532713,
-0.017318964,
-0.004672594,
0.020492801,
-0.036701575,
-0.013283097,
0.02405847,
-0.0043983115,
-0.01244719,
-0.01763243,
0.0013640644,
0.0037256673,
0.00727501,
-0.020806268,
0.0029730236,
0.0076145977,
-0.011885564,
-0.0056293164,
0.027036393,
-0.029517993,
0.00314445,
0.0032309794,
0.017057743,
-0.009972119,
-0.012505964,
-0.02910004,
-0.017488759,
-0.0061615547,
0.018389972,
-0.014445531,
-0.015190012,
-0.0008252957,
0.0014440634,
0.0142365545,
0.0021158915,
0.0050644255,
-0.018220177,
0.008848867,
-0.019421795,
0.031738374,
0.015085523,
0.0033060806,
-0.0014873281,
-0.00752317,
-0.021903396,
-0.00302037,
-0.009776203,
0.011683118,
0.0042970884,
-0.0024832338,
-0.0091884555,
-0.0034317933,
0.0025126212,
0.0017779367,
-0.018860169,
-0.012669227,
-0.012375354,
0.0103966035,
-0.010128851,
0.023784189,
0.005724009,
0.009201516,
-0.0278723,
-0.019304246,
-0.0033860796,
-0.0021844623,
0.0033501617,
-0.0153989885,
-0.02650089,
-0.015137767,
0.0337759,
0.018612009,
0.011487202,
0.0012538617,
0.010540275,
0.023967044,
-0.02800291,
0.0133026885,
-0.00033264887,
0.02036219,
0.011918217,
-0.02946575,
0.016979378,
0.0024979275,
0.002860372,
0.028342498,
0.045347996,
-0.020492801,
0.015085523,
-0.026592316,
0.018533643,
-0.021968702,
0.0015689598,
0.0017126314,
0.014837364,
-0.006053801,
-0.014014517,
0.014197371,
0.009025192,
-0.013348402,
-0.023640517,
0.015294501,
0.013263506,
-0.009057845,
0.0026742518,
0.0012987591,
-0.009763142,
-0.010670885,
0.020323008,
0.022491144,
-0.0053354427,
0.024241326,
0.02084545,
-0.012793307,
0.01232964,
-0.015960615,
0.005697887,
0.012989223,
-0.0018285483,
0.010226809,
0.0054072784,
0.011656995,
0.019643834,
-0.010102729,
0.029857581,
0.003211388,
-0.004231783,
-0.00063101243,
0.023327053,
-0.024763769,
0.00009591715,
-0.010416195,
0.019016903,
0.03218245,
0.0053680954,
0.0041958652,
-0.022882976,
0.008326425,
0.004574636,
0.011225981,
0.0037224018,
0.0126300445,
0.007719086,
0.019395674,
0.026174363,
0.0013697785,
0.0149549125,
-0.00063550216,
0.007973776,
-0.0032750606,
0.009142742,
0.013923089,
0.021994824,
0.0012612086,
0.0043689245,
-0.008816215,
-0.025051111,
0.006190942,
0.005044834,
-0.02331399,
0.020910757,
-0.0019265063,
0.002630171,
0.013949212,
0.032887746,
0.020127092,
-0.010318236,
-0.016613668,
0.024946623,
-0.0011722301,
-0.01786753,
0.008189284,
-0.011441488,
-0.0182463,
0.0088358065,
0.02059729,
0.017723856,
0.011212919,
0.009266822,
-0.005035038,
-0.027480468,
-0.011990053,
0.023091953,
-0.034011,
0.03132042,
-0.000857132,
0.0145892035,
-0.0039411746,
-0.016940193,
-0.01270188,
0.048665505,
0.018807925,
-0.010279054,
0.00055264606,
-0.007803983,
-0.02823801,
0.00937131,
-0.008535402,
-0.009828447,
-0.011265163,
-0.004205661,
0.010958228,
0.0030611858,
0.0002795883,
0.02959636,
-0.007908471,
-0.0059133945,
-0.033436313,
0.0077125556,
-0.010305176,
0.010089668,
0.00924723,
-0.0046301456,
0.0073272544,
0.01974832,
0.0049305498,
-0.0005428503,
-0.020505862,
0.012505964,
0.0027558834,
0.009012131,
-0.013896967,
-0.004104438,
-0.0019591588,
-0.015764698,
-0.0054334006,
0.0053354427,
-0.020205459,
-0.0077125556,
0.0036734228,
-0.007967246,
0.0071705217,
0.03623138,
0.016744278,
0.03563057,
-0.020989122,
0.013374524,
0.025495188,
0.014158188,
-0.016300201,
-0.019252,
0.028159644,
-0.011291286,
0.025090294,
-0.008430914,
0.004071785,
0.023601335,
-0.00837867,
0.0026481298,
-0.0055117668,
-0.00727501,
0.02687966,
0.018873231,
0.026827415,
-0.0037158714,
-0.025560493,
-0.0018726294,
-0.004656268,
0.013988394,
-0.0389742,
0.015882248,
0.004166478,
-0.0066284877,
-0.035108127,
-0.013100242,
-0.0044603515,
0.028394742,
-0.0055052363,
-0.0043232106,
-0.0042023957,
0.0008979478,
0.0015069197,
0.0018807926,
0.0076733725,
0.008411322,
-0.001998342,
-0.02033607,
-0.020061787,
0.0056293164,
-0.0029142487,
-0.0024228266,
-0.03563057,
-0.02033607,
-0.0056913565,
0.027088637,
0.029909825,
0.0065174685,
-0.026657622,
0.004437495,
0.011284756,
-0.016835704,
-0.009018661,
-0.0029387383,
-0.019056085,
-0.0030905732,
0.0068244035,
0.008594177,
-0.029021673,
-0.024633158,
0.0016163061,
0.02576947,
-0.018416094,
-0.0120945405,
-0.008574585,
-0.020401375,
-0.0055085015,
0.010370481,
0.016378568,
-0.0064913463,
-0.016548362,
0.0040750504,
-0.017162232,
0.004734634,
-0.027271492,
-0.00912315,
0.0052701375,
0.0035362819,
0.009834978,
-0.0066154264,
0.0011371284,
0.017332025,
0.0009779468,
0.019095268,
0.0032211838,
0.011689648,
0.033331823,
-0.022700122,
0.02923065,
0.026931904,
0.020127092,
0.012479842,
-0.0014293697,
0.04430311,
-0.025599675,
-0.01713611,
0.022673998,
-0.024215205,
-0.023614395,
-0.027219247,
-0.00703338,
-0.0075297006,
0.04435536,
-0.025717225,
-0.028655963,
-0.029570239,
-0.007457865,
-0.019186696,
-0.0018856904,
-0.009351718,
0.00074897014,
-0.019878931,
0.01726672,
-0.033384066,
-0.029753093,
0.038660735,
-0.035343226,
-0.011937808,
0.0066807317,
-0.021185039,
0.0022497675,
0.023980105,
-0.0035493427,
-0.010670885,
-0.0047281035,
-0.011043126,
-0.027532713,
-0.020127092,
-0.016012859,
0.022334412,
0.035186492,
0.024202142,
-0.0036832187,
0.01836385,
0.009932935,
0.0082545895,
0.009338657,
-0.009880692,
0.0045223916,
-0.0049011623,
0.007967246,
0.009880692,
-0.009756612,
0.024646219,
-0.014471654,
0.023457663,
0.027454346,
-0.026527012,
-0.014967974,
-0.01418431,
-0.02528621,
-0.02417602,
0.0069027697,
-0.014314921,
0.016848767,
-0.054229517,
-0.02651395,
0.018951597,
0.019147513,
0.021524625,
-0.021028304,
0.018612009,
-0.02232135,
0.008639891,
-0.015346745,
-0.012061888,
0.0014228391,
-0.018585887,
0.014693691,
-0.011545977,
0.0072097047,
-0.019696077,
0.021668298,
0.0047640214,
-0.013426769,
0.007777861,
0.02010097,
0.0035460775,
-0.00059182924,
-0.008241529,
-0.020127092,
-0.0135181965,
0.0031248585,
-0.022086252,
-0.019434856,
-0.011141083,
0.0049860594,
-0.02206013,
0.015999798,
-0.030249413,
-0.01011579,
0.032443672,
-0.0033632228,
0.01516389,
-0.011859442,
0.030771855,
0.016626729,
0.0012791675,
-0.018076506,
0.010755782,
-0.013034937,
0.0043852506,
0.049396925,
0.016809583,
0.010252931,
-0.019291185,
-0.0008220304,
0.0056064595,
-0.0022677265,
-0.007823574,
-0.002052219,
0.0039379094,
-0.015294501,
-0.012146785,
-0.004270966,
-0.00986763,
0.010181095,
-0.027114758,
0.026318034,
-0.018063445,
0.011225981,
-0.00013744723,
0.025926203,
-0.007555823,
0.018977718,
-0.013100242,
0.010945167,
-0.025782531,
-0.04072438,
-0.0005648908,
0.010990881,
0.0017240598,
0.010037424,
-0.017541002,
0.0143279815,
0.005769723,
0.001954261,
-0.020453619,
-0.03304448,
-0.008620299,
0.0416909,
0.018834047,
0.0064913463,
0.033018358,
0.010324767,
0.022203801,
-0.012538617,
0.000058978847,
-0.016078165,
-0.0018987515,
-0.010435786,
0.019944238,
0.0087443795,
-0.022556448,
-0.015594904,
-0.030850222,
0.0026922107,
-0.037145652,
-0.007830105,
0.021472381,
-0.023614395,
-0.014014517,
0.007823574,
0.02157687,
0.025691103,
0.0029256772,
-0.0066023655,
-0.013896967,
0.030353902,
-0.026709866,
0.02442418,
0.014641447,
0.0097696725,
0.00015928369,
-0.0018399768,
-0.030301657,
-0.014981035,
0.0074056205,
-0.02404541,
-0.022386655,
-0.025469065,
-0.002137116,
0.008450505,
0.0052668722,
-0.015059401,
0.009430084,
0.0014065128,
0.010514152,
-0.015098585,
-0.00788888,
0.023470724,
-0.027114758,
-0.002661191,
0.005361565,
-0.0032538364,
-0.0023771129,
-0.015712455,
-0.007941124,
0.00053999317,
0.0028930246,
0.0013942681,
-0.04004521,
0.012656166,
-0.026592316,
-0.011245572,
-0.0050252425,
-0.0017926304,
-0.022634815,
0.011395774,
0.017410392,
-0.014693691,
-0.058409058,
0.02108055,
0.01060558,
0.017332025,
0.001714264,
-0.012551678,
-0.008711726,
-0.023588274,
-0.014367165,
-0.0013256975,
-0.029674727,
0.041612536,
0.015895309,
-0.0020505863,
-0.02046668,
0.0053060553,
-0.03142491,
-0.0253907,
-0.0057729883,
0.007177052,
0.016861828,
0.029988192,
0.019434856,
-0.020767083,
0.0052831983,
0.013256975,
-0.04072438,
-0.018350787,
0.016548362,
-0.026905783,
0.012969632,
-0.010919046,
-0.02626579,
-0.017815284,
0.020166276,
-0.008169693,
-0.0070464415,
0.009430084,
-0.012760655,
0.010174565,
-0.007079094,
-0.018024262,
0.0053289123,
0.014510836,
0.03782483,
-0.026396401,
0.011918217,
0.008274181,
-0.00072325615,
0.0041632126,
-0.011239042,
-0.0018546705,
-0.007986838,
0.0045583094,
-0.002842413,
-0.012982693,
0.0016269182,
-0.013139426,
0.0043852506,
0.020087909,
-0.008483158,
0.008803154,
0.034376707,
-0.024855196,
-0.029753093,
-0.008587646,
-0.00028571067,
0.006145228,
-0.009136211,
-0.015490416,
-0.019304246,
-0.006066862,
0.013178608,
-0.014563081,
0.008528871,
-0.015255317,
-0.02230829,
-0.031372663,
0.014811241,
0.009821917,
-0.010063546,
-0.018376911,
0.019278124,
-0.017841406,
0.0032571016,
-0.026592316,
-0.005103609,
-0.0029991458,
-0.01774998,
0.006252982,
0.0028864942,
0.010710069,
-0.013479013,
-0.011950869,
-0.01640469,
0.021041367,
0.17846632,
0.0007481538,
-0.0017844673,
0.020740962,
0.02625273,
-0.00305139,
0.007908471,
0.003513425,
-0.010416195,
0.010370481,
0.0281074,
-0.010030894,
-0.004734634,
-0.0035917913,
0.024149898,
-0.019330367,
-0.03466405,
-0.00028652698,
0.00026856802,
0.0038758693,
-0.005459523,
-0.0032668975,
0.022543387,
-0.0116961785,
0.020323008,
0.012538617,
-0.016469996,
0.0021550748,
0.039653376,
-0.00010086607,
0.00042407628,
0.0036832187,
0.013727173,
0.0035493427,
0.011833319,
0.0037452588,
-0.016966317,
0.0017403861,
0.0031640416,
-0.020205459,
-0.010468439,
0.02369276,
-0.02552131,
-0.007111747,
-0.018755682,
0.004352598,
-0.010919046,
-0.016848767,
-0.03466405,
0.015738577,
-0.04229171,
0.0002299971,
0.021733603,
0.011415366,
-0.00065999164,
-0.009776203,
0.017593246,
0.02959636,
-0.009880692,
0.014837364,
-0.006870117,
-0.006941953,
-0.018220177,
0.00024469077,
-0.021877274,
0.022269106,
-0.01232964,
-0.024189081,
0.013779418,
-0.002248135,
0.021171978,
-0.005181975,
0.0036473009,
0.007934594,
-0.0057795187,
-0.004940346,
0.029309018,
0.012166376,
-0.0025599676,
0.016992439,
0.008071735,
-0.017175293,
-0.026853537,
0.018194055,
-0.017645491,
-0.028682087,
0.025103357,
0.012610452,
-0.022974404,
0.0043623936,
0.0025207845,
-0.00018163036,
-0.006889709,
-0.0017240598,
0.027114758,
0.0023820107,
0.00517871,
-0.002793434,
-0.011291286,
-0.018050384,
-0.04007133,
0.07653781,
0.012597391,
0.019304246,
-0.0054921755,
0.026278852,
-0.02021852,
0.037171774,
-0.0030856752,
0.012878205,
0.019800566,
-0.0239148,
0.0024587444,
-0.00875744,
-0.038138293,
0.027793935,
0.0056880913,
-0.009312536,
0.011872503,
-0.021864213,
-0.01084721,
-0.016208775,
0.023470724,
0.0015216134,
-0.0083852,
-0.007823574,
-0.03132042,
-0.00752317,
0.0049240193,
-0.032443672,
-0.01690101,
-0.004166478,
-0.018194055,
0.01430186,
0.00049632025,
-0.012767185,
0.02121116,
-0.0041991305,
-0.005501971,
0.04785572,
0.007928063,
0.0051950365,
0.008888051,
0.02637028,
0.011154145,
-0.014393288,
-0.0076145977,
0.0022709917,
-0.017345086,
-0.008424384,
-0.027480468,
-0.028917186,
0.0070007276,
0.014079822,
0.038686857,
-0.007706025,
-0.018507522,
-0.044172503,
-0.011225981,
0.002135483,
-0.025782531,
0.0115590375,
0.034585685,
-0.020531986,
-0.00083917304,
0.01244719,
-0.163211,
0.021524625,
0.014406349,
-0.018664254,
0.024633158,
0.038921956,
-0.028812697,
0.0037779114,
0.008215406,
-0.011598221,
0.04020194,
0.0019248736,
-0.040828872,
-0.021916457,
0.014471654,
0.009377841,
0.0008563157,
0.016783461,
0.03474242,
0.007497048,
0.0040260716,
-0.04331047,
0.0004510147,
-0.030380024,
0.009234169,
0.014889607,
0.01849446,
0.014902669,
0.015464294,
0.0029795542,
-0.024332752,
0.0048391223,
0.022569511,
0.015477356,
0.019003842,
-0.011317408,
0.003046492,
-0.04762062,
-0.003477507,
-0.0072031743,
0.016692033,
0.015581843,
-0.008359078,
0.015725516,
-0.0043950463,
0.027271492,
0.0033795491,
0.01011579,
0.0249205,
0.02169442,
0.015542661,
0.00035999544,
0.0059591085,
0.021224221,
0.02036219,
0.011545977,
0.016835704,
0.017841406,
-0.0005522379,
-0.0045681056,
0.010618641,
-0.021642175,
0.031242054,
0.02157687,
-0.0036603617,
-0.015607966,
-0.0029240446,
0.00616482,
-0.017488759,
-0.0012636575,
-0.023496846,
-0.020662596,
0.019826688,
-0.0064586936,
0.03636199,
-0.0015836534,
0.006941953,
0.019539345,
0.0024522138,
-0.005697887,
-0.022504205,
-0.0063215527,
-0.020296887,
-0.003921583,
-0.020323008,
0.008541932,
0.004071785,
-0.00024040512,
0.0016252856,
-0.01688795,
0.019878931,
-0.032704893,
0.008737849,
-0.015607966,
0.0024342549,
0.0030236351,
0.0041207643,
0.004303619,
-0.021289527,
-0.01923894,
0.027088637,
-0.02813352,
-0.013172078,
0.011154145,
0.03158164,
0.012767185,
-0.023340113,
-0.0040652547,
0.038556248,
0.0018203851,
-0.029517993,
-0.0060472703,
-0.0006024414,
0.008685605,
-0.018076506,
0.057050705,
0.020636473,
-0.00320649,
0.0035297512,
-0.009945997,
0.06394695,
0.022543387,
0.01773692,
0.020270765,
0.00025407842,
-0.037015043,
-0.13081957,
-0.022295227,
0.00011326387,
0.015451233,
0.005746866,
0.010546805,
-0.006187677,
0.026801294,
-0.010755782,
0.023353174,
-0.04116846,
-0.013949212,
0.0029077183,
-0.009639062,
0.0054334006,
-0.011937808,
0.0037779114,
-0.0017975282,
-0.028995551,
0.044799432,
-0.011225981,
0.0023477254,
0.007758269,
0.0058284975,
-0.01269535,
0.0057729883,
-0.004610554,
0.0040750504,
0.00998518,
0.0047803475,
0.018925475,
0.0025942528,
-0.0041860696,
0.019382613,
-0.013289628,
-0.007843166,
-0.0007195827,
-0.016600607,
0.022451961,
-0.016365508,
-0.0044179033,
0.0020914022,
0.010448847,
0.022099312,
0.0019248736,
-0.0016587545,
-0.03523874,
-0.01541205,
0.009240699,
-0.019016903,
-0.033331823,
-0.02477683,
-0.007013789,
-0.015529599,
0.007235827,
-0.0153989885,
0.019513223,
0.013583502,
-0.008280711,
-0.00007775412,
-0.0025420086,
-0.010246401,
-0.02058423,
0.0076994943,
0.025077233,
-0.0050480994,
-0.004623615,
-0.024633158,
-0.009528043,
-0.014275738,
-0.003211388,
-0.014745936,
-0.0049762637,
-0.011428427,
-0.027402103,
0.01788059,
0.0072227656,
-0.0030383288,
0.008515811,
-0.032757137,
0.010102729,
-0.008424384,
0.004411373,
-0.0070072585,
-0.006595835,
0.017083865,
0.0124929035,
-0.011761484,
0.005201567,
-0.021054428,
-0.01566021,
0.041717023,
0.02144626,
-0.031189809,
-0.0052734027,
0.010030894,
-0.014719814,
-0.006621957,
0.012244743,
0.020793207,
-0.010866801,
-0.023300929,
-0.04743777,
0.024685401,
0.002439153,
-0.018024262,
0.02181197,
0.0027036392,
0.010383542,
0.018324666,
0.018612009,
0.03761585,
0.010579458,
0.006533795,
0.010951698,
-0.0068635866,
-0.023967044,
0.010377011,
0.017096927,
0.012401476,
0.009110088,
0.025312332,
-0.0027020066,
0.010566397,
-0.011043126,
0.0108406795,
-0.027271492,
0.002509356,
-0.023222564,
0.013002285,
-0.014928791,
-0.019343428,
0.0057925796,
-0.036205254,
-0.021720542,
-0.0051264656,
-0.02489438,
-0.0075688837,
-0.00091019255,
0.026657622,
0.02849923,
0.03132042,
-0.018233238,
-0.028838819,
0.0045223916,
-0.012564739,
-0.002819556,
0.009351718,
-0.0055770725,
-0.014902669,
-0.016692033,
0.0011763116,
0.036440354,
0.0020816063,
0.022112373,
-0.027558835,
-0.0014416145,
-0.023745006,
-0.0059395167,
-0.020545047,
-0.040515404,
0.0026677214,
0.008894581,
0.02836862,
-0.0067003234,
0.008437444,
0.016234897,
-0.002470173,
-0.018507522,
-0.007013789,
0.0070072585,
-0.03847788,
-0.002460377,
-0.014262676,
0.00604074,
0.0059721693,
0.014314921,
-0.0017518146,
-0.024985807,
0.013452891,
0.007934594,
0.029282894,
0.008953356,
-0.0027020066,
-0.013270036,
0.033096723,
0.011585159,
0.009103558,
0.006422776,
0.005880742,
0.0039999494,
0.004538718,
0.022047067,
0.017554063,
0.021106672,
-0.009691306,
-0.022360533,
0.00061142084,
-0.0073076626,
0.0015599802,
-0.0020097706,
0.046027172,
0.016091226,
0.013479013,
0.0005506053,
-0.011461079,
-0.017358148,
0.018690376,
-0.019722199,
-0.023274807,
-0.03526486,
0.02528621,
-0.005449727,
0.005338708,
0.016091226,
-0.0060472703,
-0.0041240295,
0.008966417,
-0.021420138,
0.005929721,
-0.016104287,
0.00751664,
-0.0026252728,
-0.006817873,
-0.0055182977,
0.018612009,
0.031215932,
-0.00007591741,
0.024110716,
-0.02737598,
0.025011929,
0.005129731,
0.025743349,
-0.013505136,
-0.027532713,
-0.0037550544,
0.012440659,
-0.034141608,
-0.008568055,
0.028290255,
0.010318236,
0.07810514,
0.020740962,
-0.019330367,
0.0074252123,
-0.023575213,
0.035787303,
-0.016326323,
0.0050872825,
-0.010298645,
-0.020767083,
-0.0065011424,
-0.01603898,
-0.0011175369,
-0.028159644,
-0.03453344,
0.0072097047,
-0.011676587,
0.006830934,
0.013714112,
-0.015294501,
0.009501921,
-0.016587546,
-0.01751488,
0.0045681056,
-0.030850222,
0.028342498,
0.04738552,
0.023522967,
-0.00040305612,
-0.03709341,
-0.004009745,
-0.0076994943,
-0.026200484,
0.005103609,
0.021550748,
-0.015529599,
-0.0011550874,
-0.014967974,
0.031712253,
0.02084545,
-0.013080651,
0.012519025,
-0.02687966,
-0.019839749,
-0.03056288,
-0.019656895,
-0.004133825,
-0.0069223614,
-0.028394742
] |
The histone H3 Lys 9 (H3K9) methyltransferase Eset is an epigenetic regulator critical for the development of the inner cell mass (ICM). Although ICM-derived embryonic stem (ES) cells are normally unable to contribute to the trophectoderm (TE) in blastocysts, we find that depletion of Eset by shRNAs leads to differentiation with the formation of trophoblast-like cells and induction of trophoblast-associated gene expression. Using chromatin immmunoprecipitation (ChIP) and sequencing (ChIP-seq) analyses | [
-0.027939647,
-0.022297729,
-0.0038670092,
-0.032690737,
-0.018410472,
0.021757832,
-0.0077542644,
-0.0070591476,
-0.019881692,
0.009211985,
0.009279472,
-0.0029812413,
0.006536123,
0.0011607776,
-0.0131869735,
0.0031803283,
0.027021823,
0.005230248,
-0.0024970216,
0.02823659,
-0.024565294,
-0.0029424364,
0.011074629,
-0.0096574,
0.00018010612,
-0.0063944,
0.01090591,
-0.026265968,
-0.011992453,
-0.017357675,
0.01691226,
0.012012699,
-0.0021815195,
-0.021123454,
-0.027467238,
-0.0117697455,
-0.0025155805,
-0.027858663,
0.024659775,
0.0016492152,
0.021730836,
0.019436276,
-0.0126268305,
0.0010384573,
0.015184591,
0.0022422578,
0.012323139,
-0.020192131,
-0.0112231,
0.031448975,
-0.0023907295,
0.010460496,
0.0025510113,
0.0026454933,
-0.037117887,
0.001364926,
0.013713373,
-0.00022165285,
0.030990062,
-0.007194122,
0.0025543857,
-0.012930523,
-0.024376329,
0.015576016,
0.03158395,
0.026130993,
-0.023067081,
-0.011081377,
0.005027787,
0.008294161,
0.023418013,
0.008996027,
-0.02166335,
-0.012863035,
0.02694084,
-0.019665733,
-0.014158787,
-0.011155613,
0.01143231,
0.007180624,
0.021393402,
-0.013234215,
-0.03325763,
0.015886456,
0.018612934,
0.011553787,
0.009009524,
0.009947594,
0.007855495,
0.008894796,
0.033905502,
0.033527575,
0.01727669,
0.009144498,
-0.026050009,
0.010055574,
0.0003188764,
0.031610943,
0.029775295,
-0.037387837,
-0.017776094,
0.017452156,
-0.022230241,
-0.017020239,
-0.036200065,
0.00996784,
0.0033001178,
-0.005392217,
0.027858663,
-0.010264783,
-0.023067081,
0.016615316,
0.006522625,
-0.019193323,
0.023107573,
-0.018127028,
0.023215553,
0.0107506905,
-0.0070591476,
-0.0032326307,
0.0029356875,
0.021987287,
0.010163553,
-0.042867787,
0.00767328,
0.025928533,
-0.017020239,
-0.025699077,
-0.017371172,
-0.009907102,
0.014698684,
-0.02004366,
-0.0029879902,
0.008732826,
-0.034472395,
0.00955617,
-0.017776094,
-0.010298527,
-0.0126875695,
-0.023418013,
0.0018373355,
0.02468677,
0.0020684786,
-0.00078580255,
-0.0006575771,
-0.0034384662,
-0.0052639917,
0.012566092,
0.004572249,
0.015778476,
0.005679037,
0.0015834154,
0.012289396,
-0.0012906903,
0.002539201,
0.024754258,
0.014415238,
0.0064686355,
-0.008827309,
-0.015994435,
-0.02015164,
-0.024551796,
0.022729645,
0.021676848,
0.035228252,
0.034742344,
-0.0010418317,
-0.01059547,
-0.0009659087,
-0.0009498805,
-0.007815002,
0.0037826502,
-0.032015868,
-0.010123061,
-0.02406589,
-0.002643806,
-0.008111946,
0.026400942,
-0.03047716,
-0.028587524,
-0.009178242,
0.03412146,
0.028020632,
-0.0012510415,
-0.023971407,
0.004086342,
0.00824692,
-0.023080578,
0.008699084,
-0.023687962,
0.014172285,
0.0067250864,
-0.0039952346,
-0.009043267,
-0.631463,
-0.037495818,
0.017789591,
0.002672488,
0.019166328,
0.025240164,
0.008591104,
-0.004130209,
-0.007976972,
0.0031094668,
-0.019503763,
0.0077272695,
0.0028901338,
-0.011412064,
-0.023755448,
-0.036146075,
-0.008429135,
-0.016210394,
0.026225476,
-0.0049468023,
-0.042732812,
-0.0018592688,
-0.011911468,
0.022324722,
-0.008321156,
0.016264385,
0.030099234,
0.008408889,
-0.01727669,
0.024119878,
-0.023674464,
0.029397368,
-0.017519644,
0.009171492,
0.05110121,
0.01758713,
-0.00861135,
0.02488923,
-0.006937671,
0.030828094,
-0.0044710184,
-0.014307259,
0.021406898,
0.0077475156,
0.007119886,
0.019895189,
-0.0019537506,
0.0039648656,
0.006586738,
-0.0011228161,
-0.0043090493,
-0.001303344,
-0.021028971,
-0.0044170287,
0.00062172464,
0.008078203,
0.017249696,
-0.0107911825,
0.028371565,
0.00039374488,
-0.0062189335,
0.022203246,
-0.021906303,
-0.003684794,
-0.013956326,
0.016709799,
-0.0029829284,
-0.005631796,
0.005628422,
-0.026130993,
0.008294161,
0.02113695,
0.0013556465,
0.0033912254,
0.00017367376,
0.03960141,
-0.0003920577,
-0.012917025,
-0.011445807,
0.011459305,
-0.0007533244,
-0.01048749,
0.0007402488,
0.0027231034,
0.008584355,
-0.013834849,
-0.0016120974,
0.008078203,
-0.013996818,
0.015724488,
0.01216117,
0.016412856,
0.0055541857,
-0.011830484,
-0.02536164,
0.0055035707,
0.0038737578,
0.01884239,
0.013072246,
-0.02406589,
-0.02119094,
-0.0013050312,
0.010554978,
0.010116312,
-0.00044710183,
0.006596861,
-0.027723689,
0.0011734314,
0.042840794,
-0.028722497,
0.0021359657,
-0.015049617,
-0.014118295,
-0.011870976,
0.0010561727,
-0.026238972,
-0.0141857825,
0.010264783,
-0.007862244,
-0.023836434,
0.014901145,
-0.0054360833,
-0.009859861,
0.009616908,
0.008219925,
0.0224462,
0.0026977956,
0.007841998,
-0.0040391013,
-0.01523858,
0.010082568,
-0.011823735,
0.024956718,
-0.04529732,
0.03420245,
0.004602618,
0.035228252,
-0.013335445,
0.018612934,
-0.012721313,
-0.018073037,
-0.013456922,
0.005925365,
-0.006087334,
-0.012046442,
-0.013929332,
0.006910676,
-0.008948785,
0.011337828,
0.0006959604,
0.004103214,
0.0015994436,
-0.011574033,
0.012012699,
0.00902977,
-0.0166963,
-0.031287007,
-0.02490273,
-0.014941637,
-0.018707415,
-0.0069241733,
0.013760613,
-0.0064247693,
0.014833658,
-0.006930922,
-0.00030010656,
-0.008381894,
-0.019881692,
-0.011088125,
-0.013558152,
-0.006731835,
0.01523858,
-0.030558145,
0.008523617,
0.007922982,
0.017317181,
-0.0016854896,
0.0013303389,
-0.031718925,
-0.006384277,
-0.0040458497,
-0.012957517,
-0.005135766,
0.0011995827,
0.04953551,
0.012127426,
0.027021823,
-0.011951961,
0.024875734,
0.016453348,
-0.0024936472,
0.00882056,
-0.0075922953,
0.007531557,
0.018977365,
-0.03142198,
0.019139333,
0.011074629,
0.0075113107,
0.029721307,
0.037576802,
-0.008287412,
0.015481534,
-0.012836041,
-0.0017479152,
-0.03679395,
-0.0055575604,
-0.018208012,
-0.0058376314,
0.022500189,
-0.0058747493,
-0.004869192,
-0.011000392,
0.009994836,
-0.00220514,
-0.0067993226,
-0.02071853,
-0.0066002356,
-0.008260418,
-0.012431119,
-0.0018862636,
-0.0125256,
0.028884467,
-0.012964266,
0.019422779,
0.005621673,
0.026171487,
-0.0028715748,
-0.008888047,
-0.016088918,
0.0027602213,
0.023741951,
-0.015576016,
0.00527074,
0.023337029,
0.010980146,
0.032582756,
0.0026809238,
0.03841364,
-0.011843981,
-0.0121476725,
0.01884239,
0.005297735,
-0.012667323,
0.010993644,
-0.012100432,
0.026900345,
0.014253269,
-0.012478359,
0.0066879685,
-0.0059624827,
0.01137832,
-0.011142115,
0.011695509,
-0.002721416,
-0.02880348,
-0.017789591,
0.023674464,
0.021271925,
0.022122262,
0.003266374,
-0.022999594,
-0.008496623,
0.008503371,
0.009691143,
0.0042044446,
0.0005736401,
0.005463078,
-0.026036512,
-0.02880348,
-0.024119878,
-0.0011261905,
-0.008793565,
-0.0040019834,
0.0068566864,
0.00065040664,
0.009245729,
0.009171492,
0.017317181,
0.012275898,
-0.0027922776,
-0.031637937,
0.04030328,
0.015630005,
-0.012984512,
0.0150226215,
-0.022581173,
-0.015184591,
-0.0057971394,
0.011783242,
0.007173876,
0.00876657,
-0.0004783146,
0.0057498985,
-0.023472004,
-0.029289389,
0.0049501765,
-0.014239772,
0.030261202,
0.01487415,
0.009576416,
-0.019166328,
-0.03633504,
-0.0058477544,
0.033581566,
0.015157596,
0.0070119067,
0.0030689745,
-0.018977365,
-0.0034469021,
-0.004764587,
-0.017101225,
0.0052842377,
-0.01185073,
-0.00012833088,
0.019152831,
0.0007128322,
-0.0012839416,
0.031394985,
0.0019385661,
-0.013996818,
-0.019044852,
-0.0131869735,
-0.016061923,
0.016736794,
0.044244524,
-0.011452556,
0.028371565,
0.017141717,
-0.004082968,
-0.008800314,
-0.029208405,
0.010973398,
-0.01920682,
-0.011938463,
0.02625247,
-0.010878916,
-0.0073223473,
0.0024801497,
0.015886456,
0.01017705,
-0.014361248,
-0.015859462,
-0.012363631,
0.0029711183,
0.0032781844,
0.013848347,
0.044487476,
0.016007934,
0.0033338612,
0.016588323,
0.027480735,
-0.0026100625,
-0.012221908,
0.0006035875,
0.003370979,
0.0093739545,
-0.0022253862,
0.008726078,
-0.036362033,
0.006721712,
0.018491458,
-0.003168518,
0.019193323,
0.011007141,
0.030882083,
0.004848946,
0.0027163546,
-0.008543863,
-0.0036881685,
0.0010629214,
0.006499005,
-0.021096459,
-0.022149257,
0.018599436,
-0.01993568,
-0.0044777673,
-0.017492648,
-0.011290587,
-0.002195017,
-0.01101389,
0.0003637975,
-0.01116911,
-0.02160936,
0.0037185375,
-0.031044053,
-0.0011034136,
0.0069073015,
-0.0057127806,
-0.022878116,
0.009211985,
-0.017209202,
-0.017938063,
-0.013956326,
0.01769511,
-0.026873352,
-0.056311212,
-0.0047578383,
-0.0052167503,
0.020583557,
0.0033153023,
-0.013456922,
0.0001379267,
0.0224462,
-0.0029812413,
0.0046059927,
-0.004794956,
-0.025591098,
-0.0048421975,
-0.012221908,
0.0068870555,
-0.01523858,
-0.02474076,
-0.008219925,
0.019517262,
-0.01048749,
0.015791975,
-0.018046042,
-0.027548222,
0.013875342,
0.013126235,
0.018585939,
0.0038805066,
-0.0025763188,
-0.010737193,
-0.030558145,
-0.020813012,
-0.020853505,
-0.0035498198,
-0.028101616,
-0.005439458,
0.020273115,
-0.008503371,
0.012120678,
0.008638345,
-0.00861135,
0.008780068,
-0.005078402,
0.020705033,
0.027885657,
-0.011918217,
0.021865811,
-0.010973398,
0.011938463,
0.007990469,
-0.032906696,
0.020799516,
-0.0040694703,
-0.013267958,
0.005841006,
0.012309642,
-0.000014512357,
0.0001340251,
0.021528376,
-0.019085344,
0.031691927,
-0.014415238,
-0.022851123,
-0.020961484,
-0.016169902,
-0.006232431,
0.0112096025,
0.024578791,
-0.027386254,
0.00545633,
-0.0016669306,
-0.023242546,
-0.028020632,
-0.0122084115,
-0.033851516,
0.0076125413,
0.039709393,
-0.0034334047,
-0.0070996396,
0.0088138115,
-0.008800314,
-0.027264776,
-0.0016787408,
-0.01231639,
-0.03533623,
0.004076219,
-0.00845613,
0.044649445,
0.035741154,
0.044487476,
-0.003455338,
0.022216743,
-0.005652042,
0.036712967,
0.0036982915,
-0.013450173,
0.03058514,
-0.011823735,
0.033095658,
0.012802297,
-0.012383877,
0.026738377,
-0.0039682398,
0.0046532336,
0.04127509,
-0.019395784,
-0.025064697,
0.020327106,
-0.039466437,
-0.03633504,
0.023431512,
-0.021487882,
0.008705832,
-0.028074622,
-0.0055440627,
-0.008631596,
0.00083894865,
0.015832467,
-0.00017862984,
0.036631983,
-0.018086534,
0.031340994,
-0.022365214,
-0.010602219,
-0.013969824,
-0.01091266,
0.0071063885,
0.0032292563,
0.007369588,
0.007997218,
0.017816586,
0.0088138115,
-0.025780061,
0.00032457063,
0.028560529,
-0.021730836,
0.001040988,
-0.0066103586,
-0.022419205,
-0.009454939,
-0.018653426,
-0.015643504,
-0.03889955,
0.012100432,
0.014226275,
-0.020583557,
0.0019537506,
-0.0049468023,
0.00996784,
0.014806664,
-0.009576416,
0.017857078,
-0.020907495,
0.0053179814,
0.016304877,
0.00088914216,
-0.02594203,
-0.01487415,
-0.015980938,
0.0155625185,
0.040924158,
0.01836998,
-0.0032140717,
0.000007967956,
0.007578798,
0.009711389,
-0.029397368,
-0.032798715,
-0.012302893,
-0.0093942005,
0.008010715,
-0.0063910256,
-0.008557361,
-0.016061923,
-0.0048995614,
-0.011722504,
0.022729645,
-0.0046734796,
-0.0036712966,
-0.008368397,
0.01440174,
-0.0044271518,
0.020597054,
0.011344576,
0.013875342,
-0.014347752,
-0.03673996,
-0.013706624,
0.015859462,
-0.004953551,
0.028641513,
-0.020381095,
-0.001627282,
0.022216743,
0.00052091584,
-0.0073155984,
-0.02040809,
-0.0030571644,
0.036497008,
-0.017789591,
0.00054833246,
0.004788208,
0.0043292954,
0.008962283,
-0.012856287,
-0.010689952,
0.0009996522,
-0.028101616,
-0.0031128412,
0.028155606,
0.00038024745,
-0.013254461,
-0.011783242,
-0.023431512,
0.00051922863,
-0.03887255,
-0.02264866,
0.008692334,
-0.037873745,
-0.009846363,
0.0015429232,
0.0182755,
0.03320364,
0.0068364404,
0.01231639,
-0.0025915036,
0.020286614,
-0.0009220421,
0.012032945,
0.002500396,
-0.0031145283,
-0.019854696,
-0.0011869288,
-0.018464463,
-0.051128205,
-0.0038602604,
-0.011020639,
-0.034580376,
-0.000596417,
-0.003522825,
0.022594672,
0.025564102,
-0.023512496,
0.007423578,
0.00647201,
0.032798715,
0.0063437847,
-0.012741559,
0.02896545,
-0.034526385,
-0.016061923,
0.018262,
-0.0062290565,
-0.015144099,
-0.0011110059,
-0.014199279,
-0.010197297,
-0.025496615,
-0.0022591297,
-0.008368397,
-0.002178145,
-0.00498392,
-0.0062762974,
0.008287412,
-0.021514878,
-0.011216351,
-0.0062088105,
-0.00185252,
-0.006964666,
-0.031206021,
0.0031010308,
0.000901796,
0.015508529,
-0.0029323131,
0.0014703745,
-0.0072481115,
-0.034634363,
-0.030423172,
0.013585147,
-0.00918499,
0.034904312,
0.015117104,
-0.02619848,
-0.027264776,
-0.007875741,
-0.06408572,
-0.030315192,
-0.015468037,
0.002043171,
0.018208012,
0.007929731,
-0.0023552987,
-0.024443816,
-0.0112500945,
0.0065732407,
-0.003961491,
-0.027858663,
0.011601027,
-0.028533533,
0.026171487,
0.016547829,
-0.0061683184,
-0.0022186374,
0.037333846,
0.013247712,
-0.006080585,
0.027129803,
-0.024173869,
0.016169902,
-0.005277489,
0.010082568,
0.00031022963,
0.018410472,
0.025969025,
-0.027939647,
-0.007437075,
0.0063437847,
-0.010730444,
-0.042354885,
0.0030790975,
0.0006044311,
-0.0006761361,
-0.008010715,
-0.017884074,
-0.010345768,
-0.010359265,
-0.015265576,
0.022999594,
0.010730444,
0.01967923,
0.006070462,
0.03158395,
-0.0012636954,
-0.016223893,
-0.0020381096,
-0.01523858,
0.0052808635,
-0.007437075,
-0.01769511,
-0.013659383,
-0.008577607,
-0.011756248,
-0.005486699,
-0.013814603,
0.012066688,
0.00048421972,
-0.023620475,
0.009961092,
0.0038805066,
-0.01185073,
-0.009299718,
-0.0009962779,
-0.002108971,
-0.02563159,
0.0014644695,
0.000049402646,
-0.02891146,
-0.01753314,
-0.010696701,
-0.013328697,
-0.007531557,
-0.0066306046,
-0.013672881,
-0.015049617,
0.022054775,
0.18302493,
-0.0075113107,
-0.015818968,
-0.010224291,
0.011682012,
-0.019247312,
0.0057903905,
0.0042044446,
0.008071453,
-0.003779276,
0.009056765,
0.004599244,
-0.024173869,
-0.000041994885,
0.030423172,
-0.025024205,
-0.021730836,
0.004558752,
-0.024929725,
-0.012350134,
0.010824926,
-0.023768947,
0.015225083,
-0.00955617,
0.034283433,
-0.014671689,
-0.017033737,
0.024160372,
0.014766171,
-0.0030402925,
-0.038980532,
0.010143307,
0.0065529947,
-0.018936872,
0.0051323916,
0.0024801497,
-0.0051492634,
-0.0042348136,
-0.009745133,
-0.0021595862,
-0.009218734,
0.003301805,
0.009421195,
0.017789591,
-0.00013571228,
0.0053146067,
-0.0044642696,
0.0011126931,
-0.0048658177,
-0.0050851507,
-0.03582214,
0.013969824,
0.013355691,
0.0203541,
0.012093683,
-0.005344976,
0.01487415,
0.002594878,
-0.010932906,
0.0102310395,
-0.004980546,
0.016588323,
-0.039655402,
0.00025792714,
-0.010393009,
0.030666124,
-0.022945603,
-0.01816752,
0.020840008,
-0.024038894,
0.012761805,
0.0020853505,
-0.03220483,
0.0057735187,
0.00955617,
-0.017384669,
0.042111933,
0.012093683,
0.023067081,
0.03987136,
0.0073628393,
0.005517068,
-0.022716148,
0.0077272695,
0.01137832,
-0.0501024,
0.046485092,
0.0011017264,
-0.022662159,
0.0019976173,
0.01733068,
-0.014739176,
-0.006461887,
-0.009745133,
0.037765764,
-0.008422387,
0.020192131,
0.012964266,
-0.016399357,
0.0067993226,
-0.039520428,
0.07013256,
0.016817778,
0.015737984,
-0.0067993226,
0.01179674,
-0.0037286608,
-0.0047038486,
0.014077803,
-0.021298919,
0.0112703405,
-0.016655808,
0.02286462,
0.00051796326,
-0.009211985,
0.018302493,
-0.0016745229,
-0.017668115,
0.06278997,
-0.018019048,
0.0053044837,
-0.018585939,
0.0005470671,
0.044595458,
0.0016576512,
-0.0025257035,
-0.029532341,
-0.0030183592,
-0.024187366,
-0.032339804,
0.0024379704,
0.019706225,
0.017357675,
0.0047038486,
-0.0032005743,
-0.041248098,
0.020732028,
0.004305675,
-0.007160378,
0.038278665,
-0.0028378314,
-0.009677646,
-0.0035194508,
0.015279072,
0.007909484,
-0.000434448,
0.013254461,
0.045594264,
-0.04081618,
-0.018990861,
-0.012437867,
-0.028371565,
-0.006556369,
-0.003426656,
0.036389027,
-0.028074622,
-0.021501381,
-0.026211979,
-0.022297729,
0.013942828,
-0.027359258,
0.0260905,
0.008051207,
-0.016102415,
0.0014104798,
0.00045933388,
-0.17082328,
0.0053989654,
0.011391818,
-0.025172677,
0.016507337,
0.027494233,
-0.0005086838,
-0.0065799896,
-0.018963866,
0.0057600215,
0.015333062,
0.016709799,
-0.058254838,
-0.026967833,
0.0005183851,
0.023809439,
0.005000792,
0.025969025,
0.016169902,
0.012532349,
0.014725679,
-0.0043090493,
0.024848739,
0.012512103,
0.018909877,
0.027156796,
0.018140525,
-0.017965058,
-0.0053011095,
-0.028533533,
-0.030315192,
-0.0007988782,
0.021366406,
0.007815002,
0.0098126205,
-0.0020651044,
0.015913451,
0.004535131,
0.006900553,
0.030882083,
0.018491458,
0.013983321,
-0.0020144891,
0.024173869,
0.008429135,
0.038170688,
-0.027669698,
0.006164944,
0.032366797,
-0.0063944,
0.013375937,
-0.010278281,
-0.018248504,
0.017182209,
0.018882882,
0.0219198,
0.00704565,
0.010703449,
-0.00720087,
-0.015859462,
-0.006738584,
-0.021258427,
0.043056753,
-0.014725679,
-0.0024835241,
-0.023687962,
0.000075659336,
0.015333062,
-0.03220483,
-0.0028074621,
-0.009819369,
-0.023391018,
-0.0032140717,
-0.021285422,
0.031637937,
-0.0076125413,
0.013875342,
0.035957113,
0.011094875,
-0.008543863,
-0.03366255,
0.018761406,
-0.021649852,
-0.021325914,
-0.0013269645,
0.009907102,
-0.0112703405,
-0.00019349808,
-0.0075180596,
0.0032326307,
0.012559344,
-0.0033625432,
0.022149257,
-0.009050016,
0.03763079,
0.02218975,
-0.017924566,
-0.012923774,
-0.0069039273,
0.001350585,
0.029451357,
-0.011816986,
-0.008726078,
0.024592288,
0.025483118,
-0.0015775103,
-0.021568868,
0.0136053935,
0.050561313,
-0.01895037,
-0.033500582,
-0.0026859853,
0.01847796,
0.02384993,
0.0027231034,
0.041734003,
0.0042145676,
0.00072843855,
-0.0029086927,
-0.026009517,
0.07817702,
-0.01816752,
-0.016790783,
0.018653426,
0.0009026396,
-0.032663744,
-0.12957518,
-0.0065057534,
0.003809645,
0.013969824,
-0.0027568468,
0.031152032,
0.0032208203,
0.031934883,
-0.015265576,
0.031017058,
-0.030153222,
-0.0043967827,
0.012323139,
-0.008199679,
0.0075248084,
0.011121869,
0.00725486,
-0.02552361,
-0.015913451,
0.051182196,
0.001694769,
0.013888839,
0.0064112716,
-0.0053854682,
0.026792366,
0.019017857,
-0.022095267,
0.018653426,
0.030774103,
0.025280656,
-0.004150455,
-0.0234855,
0.02364747,
0.0000046364407,
-0.019530758,
-0.007187373,
-0.015441041,
-0.022527184,
0.03846763,
-0.0151036065,
-0.0025780061,
0.00605359,
0.00013297061,
0.004130209,
0.00876657,
-0.013450173,
-0.025645087,
-0.0028395185,
0.024659775,
-0.009907102,
-0.03752281,
-0.03179991,
-0.0141857825,
-0.0035734405,
0.011756248,
-0.010622465,
0.018558944,
0.026522418,
-0.03930447,
-0.002729852,
0.012566092,
0.0021494632,
-0.0053483504,
-0.008685586,
0.013996818,
-0.017776094,
-0.023161562,
-0.03366255,
0.013497414,
-0.021150447,
-0.007025404,
0.016399357,
-0.01341643,
0.0025543857,
-0.020691536,
0.0027534724,
-0.022054775,
-0.0053989654,
0.0068735583,
-0.011601027,
0.00097012665,
-0.02202778,
0.022635164,
-0.007909484,
0.02421436,
0.018410472,
0.017776094,
-0.014131793,
-0.011466053,
-0.011830484,
0.00902977,
0.04327271,
0.016453348,
-0.013740367,
-0.0131869735,
0.010527983,
-0.007693526,
-0.011034136,
0.025186175,
0.023890423,
0.00618519,
-0.008503371,
-0.06656925,
0.0040391013,
-0.008462879,
-0.023337029,
0.00668122,
-0.015333062,
0.010197297,
0.0078015053,
0.012923774,
0.022675656,
-0.009778877,
-0.005442832,
-0.023418013,
-0.011870976,
-0.026684389,
0.010784434,
0.020070655,
-0.012397375,
0.023067081,
0.022972599,
0.005213376,
-0.018990861,
-0.015832467,
0.0011211289,
-0.009765379,
-0.009630405,
0.0150226215,
0.009225482,
-0.012957517,
-0.00788249,
0.014901145,
-0.034067474,
-0.0073560905,
0.0016382487,
-0.00882056,
-0.010521234,
-0.016291378,
0.038764574,
0.024470812,
0.008962283,
-0.018626431,
-0.010143307,
0.00034397317,
0.009819369,
-0.007194122,
-0.001860956,
-0.026657393,
-0.00950218,
-0.009117504,
-0.005260617,
0.04597219,
0.009961092,
0.012991261,
0.005189756,
-0.007025404,
-0.024200864,
0.0018812021,
0.019976173,
-0.009724887,
-0.01137832,
-0.004649859,
0.033905502,
0.018909877,
0.0145637095,
-0.012404123,
0.003721912,
-0.027224284,
-0.011749499,
0.01816752,
-0.029424362,
-0.028857471,
-0.0021832066,
0.010413255,
0.013699875,
0.0029474979,
-0.0029711183,
-0.005459704,
-0.001889638,
-0.027183792,
0.028263586,
0.0025577599,
-0.009407697,
-0.0038771322,
0.0044237776,
0.012923774,
-0.024808247,
0.0035363224,
0.01764112,
-0.006556369,
0.017047234,
0.0072413627,
0.030504156,
0.006569866,
0.014658191,
0.00370504,
0.019287804,
0.021096459,
0.0068836813,
0.010507737,
0.027008325,
0.003732035,
0.005938862,
0.021636356,
-0.0066947173,
-0.011236597,
0.036551,
-0.018464463,
-0.028209595,
-0.001580041,
-0.009900353,
-0.0066373535,
0.012012699,
-0.0018812021,
0.005675663,
-0.036551,
0.00022270733,
0.0037252863,
-0.013234215,
-0.014617699,
0.031556953,
0.0018170894,
0.0069039273,
0.0060164724,
-0.0038568862,
0.010703449,
-0.011121869,
0.023080578,
-0.024200864,
0.03074711,
0.009050016,
0.020502573,
0.0127888,
-0.01649384,
-0.025591098,
-0.001026647,
0.0017065794,
-0.0031651435,
0.013679629,
-0.012343385,
0.10220242,
0.008273914,
-0.027885657,
0.00227094,
-0.0103120245,
0.0333926,
0.013558152,
0.0024008525,
-0.018963866,
-0.003701666,
0.017600628,
-0.029397368,
0.024943221,
-0.017870577,
-0.000327945,
0.010150055,
-0.005814011,
0.017789591,
-0.0117292525,
-0.0066677225,
0.008510119,
-0.016750291,
0.010703449,
0.011776494,
-0.011762996,
0.01911234,
0.02135291,
-0.003951368,
-0.000508262,
-0.016655808,
0.0005905119,
0.004801705,
-0.04165302,
0.0011093187,
-0.0010106189,
-0.0006288951,
-0.011864227,
-0.030612135,
0.046593074,
0.011931714,
-0.010642711,
-0.00043740057,
0.009299718,
-0.020421587,
0.003988486,
-0.0018356483,
-0.00913775,
0.0066947173,
-0.015184591
] |
OBJECTIVE To determine rates of suicide associated with pregnancy by the type of pregnancy. DESIGN Register linkage study. Information on suicides in women of reproductive age was linked with the Finnish birth, abortion, and hospital discharge registers to find out how many women who committed suicide had had a completed pregnancy during her last year of life. SETTING Nationwide data from Finland. SUBJECTS Women who committed suicide in 1987-94. RESULTS There were 73 suicides associated with pregnancy, representing 5.4% of all suicides in women in this age group. The mean annual suicide rate was 11.3 per 100,000. The suicide rate | [
-0.0052478584,
-0.019999111,
0.02763236,
-0.04236453,
-0.03478217,
-0.008784597,
-0.023077855,
0.015253775,
-0.019121287,
-0.027098034,
-0.008517433,
0.017874524,
0.003081924,
-0.0005172321,
-0.00029916767,
0.018905012,
0.0381408,
-0.005600896,
0.018141687,
-0.01858696,
-0.012626666,
-0.0040392606,
-0.008161215,
0.0026191585,
-0.012391307,
-0.0031153196,
0.0099168625,
-0.031525318,
-0.00090326776,
-0.026614593,
-0.010184026,
-0.010336691,
-0.012874746,
-0.0010622938,
-0.033433627,
-0.01772186,
-0.0013008328,
-0.0005013295,
-0.006252903,
-0.025215164,
0.0146812815,
0.00831388,
-0.00049139035,
0.022454472,
0.010521161,
0.011742481,
-0.011348097,
-0.002800448,
-0.0210296,
0.0033172825,
-0.0005482422,
0.01730203,
-0.029540673,
0.018141687,
0.013485406,
0.015877157,
-0.019668337,
-0.0010193568,
-0.0075123888,
-0.011653426,
0.0016188849,
-0.0102539975,
-0.034222398,
0.016436929,
0.003460406,
0.0049425284,
-0.023446795,
0.028726459,
-0.013714404,
0.0063101524,
0.029489784,
0.033535406,
0.01712392,
-0.009967751,
0.00183357,
-0.0025539577,
0.010222192,
0.0008849798,
-0.0065327887,
0.02976967,
0.02127132,
-0.007270669,
0.00800855,
0.006132043,
-0.0048948205,
0.010896462,
-0.012149587,
0.0401,
0.022950634,
-0.0019146733,
0.0020466647,
0.011354458,
-0.0030055917,
0.023217797,
0.024553616,
0.014337786,
-0.008943623,
0.018866846,
-0.0007593492,
-0.025138833,
-0.008282075,
0.015037499,
-0.020571604,
-0.0018001745,
0.0013127597,
-0.02653826,
-0.0101713035,
-0.014566783,
-0.004077427,
-0.02236542,
-0.016207932,
0.051804315,
-0.009395257,
0.0008173937,
0.019108566,
-0.018905012,
-0.011061849,
-0.007804997,
-0.022276364,
-0.025762213,
0.02231453,
0.00043135806,
0.05104099,
-0.023370463,
0.0035526413,
0.016602315,
-0.033179186,
0.007506028,
-0.013892513,
0.004236453,
-0.02127132,
0.0071816146,
0.010050444,
0.007544194,
-0.008332963,
0.03363718,
-0.008829124,
-0.009210787,
-0.011926951,
-0.033102855,
0.02628382,
0.014045178,
-0.026869034,
-0.009153537,
0.001968742,
0.037988134,
0.050048668,
0.0024124247,
-0.011659787,
0.006889007,
0.0010201519,
-0.013676237,
0.01889229,
-0.002665276,
0.009878696,
-0.00489164,
-0.0050347634,
0.02763236,
-0.03788636,
-0.026792703,
-0.0029594742,
0.0119587565,
-0.01937573,
0.021881979,
-0.0041060518,
0.015724491,
-0.006306972,
0.008771875,
0.011933312,
-0.012575777,
0.009357091,
0.007359724,
-0.02536783,
0.010521161,
0.0074805836,
0.00910901,
-0.008014911,
0.015291941,
-0.011080933,
-0.020126332,
-0.019948224,
0.0027654623,
0.026182042,
0.010788324,
-0.019757392,
0.007378807,
0.013230965,
-0.013256408,
-0.012098699,
0.0037911802,
0.001307989,
0.02024083,
-0.003966109,
0.003466767,
-0.65666294,
-0.0046785455,
0.006583677,
-0.0028465656,
0.027861357,
0.030660216,
-0.0036703204,
0.015762659,
-0.025418717,
0.016424207,
-0.008784597,
0.04058344,
0.026207486,
-0.016602315,
-0.013778014,
-0.013281853,
-0.022060089,
0.012855663,
-0.005066569,
-0.03111821,
-0.0060588913,
0.018256186,
-0.028980901,
0.033586293,
0.03254308,
0.0059412117,
0.029006345,
-0.0021468513,
-0.0072452254,
0.03796269,
0.009986834,
0.03300108,
0.003581266,
0.02671637,
0.040634327,
-0.04567227,
-0.0015338059,
0.03434962,
0.015508217,
0.038929567,
-0.022136422,
-0.0076205265,
0.0073406408,
-0.00782408,
0.009528839,
-0.00039279426,
0.010190387,
-0.019477505,
0.048496574,
0.012512167,
0.0044781724,
0.029108122,
-0.0066663707,
0.000666319,
0.0016952173,
-0.0004412972,
0.009509755,
-0.01650054,
-0.022390863,
-0.00635786,
0.0036416957,
-0.020533439,
0.006583677,
-0.011259042,
-0.02928623,
0.02279797,
-0.004726253,
0.00800855,
0.0021691148,
-0.0009605171,
0.0044113817,
0.013968845,
0.0055849934,
-0.021678425,
0.021105932,
0.016793147,
0.026640037,
0.038649682,
-0.023408629,
-0.013841624,
-0.010120415,
-0.031347208,
-0.020826047,
-0.006590038,
0.011259042,
-0.017861802,
-0.0037148476,
0.01980828,
0.005648604,
-0.007735025,
-0.007544194,
-0.0074424176,
-0.007735025,
0.0038961372,
-0.0051333597,
0.01485939,
-0.0026636857,
-0.009013594,
0.01681859,
-0.01057205,
-0.017709136,
-0.0101713035,
-0.008460184,
0.021207709,
0.0036512373,
0.028879125,
-0.043992955,
-0.0055849934,
0.031219987,
-4.954033e-7,
-0.00929348,
0.016615039,
0.023179632,
-0.014274175,
0.019477505,
-0.025634993,
0.027861357,
0.0070798383,
-0.0118760625,
-0.012798414,
0.025291497,
0.012435834,
0.0069589783,
-0.0018287991,
-0.013727126,
0.032848414,
-0.0028227118,
0.0063196938,
0.006761786,
-0.029438896,
0.003148715,
0.0096624205,
0.012162309,
0.02059705,
0.00027352475,
-0.03490939,
0.0068063135,
-0.012486722,
0.0041823843,
-0.009732392,
-0.04406929,
0.0029706059,
0.002708213,
-0.004773961,
0.0020736991,
-0.04432373,
0.0060493494,
-0.0075187497,
0.0036162515,
-0.012779331,
0.005721756,
-0.007073477,
0.0062210974,
0.00397247,
-0.012683915,
-0.0028767807,
-0.014236009,
-0.039947335,
-0.0004901977,
0.0065455106,
0.01540644,
0.02231453,
-0.012785692,
0.008364769,
-0.019821003,
-0.024044733,
-0.016665926,
0.013879791,
-0.005057027,
-0.0056104376,
-0.0056390623,
-0.0190704,
0.0033109216,
0.018536072,
0.0074869446,
0.009089927,
0.003918401,
0.005387801,
-0.003613071,
-0.004249175,
-0.01008861,
-0.008797319,
-0.025075221,
0.007054394,
0.018561516,
0.027276142,
0.019095844,
0.012970162,
0.009446145,
0.0015489134,
-0.0080403555,
0.036715925,
-0.018714182,
0.014872112,
-0.008911817,
0.012136865,
-0.0038802347,
-0.0048248493,
-0.016894924,
0.025202442,
0.027505139,
-0.014452284,
0.016754981,
-0.00403608,
0.012003284,
0.00023376824,
-0.00489164,
-0.0067808693,
0.029540673,
-0.008053077,
0.011239959,
-0.01283658,
-0.02078788,
-0.02029172,
-0.01889229,
-0.003314102,
-0.0011346505,
0.003282297,
-0.0041664816,
0.002860878,
0.0009509756,
-0.002121407,
0.03483306,
0.014528616,
-0.0011791779,
-0.00017681705,
-0.002476035,
-0.014108788,
0.009821447,
-0.008065799,
-0.0038039023,
0.019223064,
-0.012779331,
0.020329885,
0.0050824713,
0.014350507,
0.01320552,
-0.022339974,
0.01137354,
0.018879568,
-0.0105148,
0.0022454474,
0.018472461,
-0.010667465,
-0.0024283272,
-0.017441973,
0.021869257,
-0.0005669277,
-0.000079662095,
0.017505584,
-0.0149357235,
0.01222592,
-0.01351085,
0.016258819,
0.0046690037,
-0.0013549016,
-0.015291941,
-0.013307297,
-0.0021500317,
0.0083838515,
0.030176776,
0.0011537337,
-0.007894051,
0.007919496,
-0.0081294095,
-0.005842616,
-0.008218464,
0.007601443,
-0.0010956893,
-0.02560955,
-0.019413896,
0.0005458568,
0.016462373,
-0.0035081138,
0.03447684,
-0.007385168,
0.020189943,
0.015380996,
0.011468956,
-0.011488039,
-0.020355329,
-0.0065200664,
0.018497907,
0.04567227,
-0.0013652383,
-0.005448231,
0.02658915,
0.014248731,
-0.00045640467,
0.0018494725,
0.016373318,
0.02989689,
0.0040869685,
0.0043986593,
-0.014655838,
-0.019681059,
0.030253109,
-0.033230077,
0.011933312,
-0.025202442,
0.015826268,
-0.006093877,
-0.025151554,
0.018281631,
0.014388674,
0.0013413844,
0.001925805,
-0.023484962,
0.006768147,
0.0015870796,
0.0027797746,
-0.018497907,
-0.0123849455,
0.020533439,
-0.014579505,
0.013701681,
-0.003447684,
0.0044336454,
0.0067745084,
0.026690926,
-0.0027400183,
-0.00507293,
-0.018230742,
-0.010056805,
0.07373718,
0.022708915,
0.011475317,
0.015762659,
0.034807615,
0.0018685557,
0.012085977,
-0.013294575,
0.009955028,
0.0169967,
0.0023933414,
0.00051246135,
-0.0008969067,
-0.01588988,
0.026131155,
0.009331646,
0.0017826816,
-0.035062056,
0.011163626,
-0.025711326,
-0.0057122144,
-0.010533883,
0.019782836,
0.033153743,
0.009910502,
-0.013040133,
0.032593973,
0.03516383,
0.016589593,
-0.01627154,
-0.014401396,
0.041524872,
-0.008981789,
0.06803769,
-0.008504711,
0.0015505037,
0.0459776,
-0.020558883,
0.011456234,
-0.013536294,
0.012702998,
-0.004452728,
0.0014137413,
-0.0056422427,
-0.00039836016,
-0.017632805,
0.015495495,
0.011812452,
-0.003129632,
-0.0025968947,
0.046664592,
0.007506028,
-0.0028211214,
-0.02798858,
0.0024728545,
0.0038579712,
-0.0017381543,
0.00672362,
-0.008784597,
-0.012989244,
-0.01094735,
-0.016424207,
0.001723842,
-0.007677776,
-0.00012920864,
-0.019490229,
-0.03587627,
0.008142132,
-0.028955456,
-0.034629505,
0.025953045,
-0.025393274,
-0.028344797,
0.0094079785,
0.0054450505,
0.025978489,
0.01889229,
-0.0027463792,
0.013091021,
0.026792703,
-0.021754758,
-0.003031036,
-0.021105932,
0.005146082,
-0.01161526,
0.010215831,
-0.005165165,
-0.02469356,
-0.015393718,
0.009268036,
0.0035844464,
0.0054545924,
-0.008663737,
-0.0026239292,
0.009865974,
0.016207932,
0.005960295,
0.041982867,
0.0025332845,
0.0047676,
0.03753014,
-0.027403362,
0.0071498095,
-0.022238197,
0.0027781844,
0.0035717243,
-0.014146954,
0.008237547,
-0.014694003,
0.011691593,
0.023701238,
-0.020978712,
0.009338007,
0.015902601,
0.040176332,
0.028472017,
0.015635438,
0.022327252,
0.02456634,
-0.02181837,
0.0078113577,
-0.01485939,
-0.0048312102,
-0.00032361795,
-0.024935279,
0.01418512,
-0.00038921618,
-0.016360596,
-0.03081288,
-0.008759153,
0.009630616,
0.048013136,
-0.009522478,
-0.029235343,
-0.007995828,
-0.0030246747,
-0.028599238,
0.02133493,
-0.00092712167,
-0.0058839624,
-0.010813769,
0.020507995,
-0.022301808,
-0.027530583,
0.032314084,
-0.027276142,
0.00898815,
0.0017461056,
-0.013167354,
0.017111199,
-0.00495207,
0.010928268,
-0.026385596,
-0.0074551394,
-0.025456885,
-0.018294353,
-0.011150904,
0.009325285,
0.05307652,
-0.025469607,
0.017887246,
0.022327252,
0.008981789,
0.003593988,
0.008352046,
0.008485628,
-0.002011679,
0.0040869685,
0.007798636,
0.02646193,
-0.008167576,
0.0034063372,
0.00015773393,
0.005308288,
0.011710675,
0.02181837,
-0.02928623,
-0.027174365,
-0.013052856,
-0.02194559,
-0.010476634,
-0.014274175,
0.001602187,
0.008854568,
-0.05984467,
-0.0006039013,
-0.0024283272,
-0.0052669416,
0.01124632,
-0.022085533,
0.01082013,
-0.025558662,
0.027454251,
-0.0047230725,
0.0052096923,
-0.011055488,
-0.010502078,
0.00087623333,
0.0009827807,
0.0057472,
0.0064278315,
0.036715925,
0.006755425,
-0.0105974935,
-0.009477951,
0.020571604,
-0.048674684,
0.0016936271,
0.015380996,
-0.01919762,
-0.018332519,
-0.019324841,
-0.0029467521,
-0.010451189,
-0.02671637,
0.0038738737,
0.00360671,
0.023853902,
0.000028003487,
-0.021487596,
-0.04279708,
-0.032415863,
0.019668337,
0.015062944,
0.020902378,
-0.0023519946,
0.007874968,
-0.030176776,
0.008587405,
0.018179854,
0.0010042493,
0.014706725,
0.019350285,
-0.015419162,
-0.002164344,
0.004713531,
0.027148921,
-0.019006789,
-0.034934834,
0.00086748693,
0.030482106,
-0.009503394,
0.0028990442,
0.005788547,
-0.018294353,
0.0062210974,
-0.008797319,
-0.0100822495,
0.013854346,
-0.014604949,
-0.0029578838,
0.031245431,
-0.03905679,
0.035189275,
-0.012944718,
-0.011780647,
0.020622494,
-0.019363007,
-0.028141243,
-0.0069844224,
-0.012804775,
0.027708692,
-0.017149365,
0.011316291,
0.008981789,
-0.014948445,
-0.015838992,
0.00045799493,
-0.01889229,
0.027148921,
0.008759153,
-0.011977839,
0.0025460066,
0.0049043624,
-0.009363452,
0.0030676117,
-0.014452284,
-0.0058235326,
0.003632154,
-0.021449428,
0.010565688,
0.0016968076,
-0.017963579,
0.0037879997,
-0.02842113,
-0.009217148,
-0.013485406,
-0.032059643,
0.012690276,
-0.018625127,
-0.013943401,
-0.014401396,
-0.012474,
0.0033872542,
0.0033967956,
-0.005880782,
-0.011647065,
0.020495273,
-0.026309263,
-0.0062147365,
0.011201792,
0.018014466,
-0.011303569,
0.014312341,
-0.023637626,
-0.0119587565,
-0.019731948,
0.009649699,
-0.03099099,
-0.00055619347,
-0.0034095177,
0.004067885,
0.010858296,
-0.016678648,
0.039871003,
0.011780647,
-0.0062878886,
-0.0076078046,
-0.010985517,
0.027657805,
-0.024032012,
0.022937912,
-0.0018558336,
0.0057853665,
0.013625349,
-0.036207043,
0.0057758247,
0.0005625545,
-0.02964245,
-0.011755203,
-0.0031932422,
0.009115371,
-0.008237547,
0.013930678,
-0.00868282,
0.00458631,
-0.03381529,
0.033026524,
-0.0025094305,
-0.011545288,
-0.0021866076,
0.0055118417,
0.023205075,
0.008542878,
0.025622271,
-0.027250698,
0.0131546315,
-0.0031980132,
-0.01540644,
0.012633027,
0.0010002736,
0.034146067,
0.004799405,
-0.02941345,
-0.0111890705,
-0.004932987,
-0.019477505,
0.020876935,
0.0034222398,
0.013294575,
0.005670868,
0.023930235,
-0.018408852,
0.016258819,
0.008447462,
0.0043859375,
-0.04114321,
-0.024998888,
0.031398095,
-0.008651015,
0.020533439,
-0.0040010945,
-0.010101332,
-0.015928045,
0.011163626,
-0.01778547,
-0.019388452,
0.016513262,
-0.023497684,
0.014197842,
-0.009000872,
-0.013625349,
-0.031067321,
-0.016767703,
0.01137354,
-0.027683249,
-0.004761239,
0.00003468755,
0.0112781245,
-0.001986235,
-0.020126332,
-0.002065748,
0.0005943597,
-0.00226135,
-0.03050755,
0.007665054,
0.0088100415,
-0.012022367,
0.009757836,
-0.0033395463,
-0.00046554866,
0.02976967,
-0.012359502,
-0.0115325665,
0.025113389,
0.015482773,
-0.03348452,
0.008231186,
0.004468631,
0.00008905457,
-0.010247637,
-0.013052856,
0.0050697494,
-0.009929584,
-0.0016252459,
-0.011627982,
-0.029515227,
-0.008033995,
0.017111199,
-0.012543972,
-0.00672362,
-0.0053146495,
-0.0057853665,
-0.030736547,
0.005782186,
-0.009649699,
-0.007525111,
-0.02885368,
-0.0006285503,
-0.0006524042,
-0.014910279,
0.021360375,
0.00996139,
0.00043453858,
-0.014884835,
0.031321764,
0.18116243,
-0.013956123,
-0.00032799115,
0.01302105,
0.016971257,
-0.017340196,
-0.00008890548,
-0.010642021,
-0.00635786,
0.0129828835,
0.000084780746,
-0.004163301,
0.013116466,
0.009859613,
0.014337786,
-0.03478217,
-0.026054822,
-0.014897557,
-0.022060089,
0.017963579,
0.013765291,
0.017836358,
0.010998239,
0.015088388,
-0.0021913785,
0.020813325,
-0.008167576,
0.0027177546,
0.0056581455,
0.0012340419,
-0.019592006,
-0.011157265,
0.015813546,
0.019477505,
0.012970162,
-0.016958535,
0.01265847,
-0.020927824,
0.0011441922,
-0.011424429,
-0.019426618,
0.030074999,
-0.00965606,
-0.00016518828,
-0.016983978,
0.018790513,
-0.0073533626,
-0.027835913,
-0.02524061,
-0.008969068,
-0.032670304,
0.01118271,
-0.0099168625,
-0.00831388,
-0.014197842,
0.031092767,
0.022021923,
-0.011996922,
-0.008053077,
0.018408852,
0.02078788,
0.004786683,
-0.026487373,
0.022060089,
0.000008286746,
-0.0041601206,
-0.013001967,
-0.00990414,
-0.0064532757,
-0.013472684,
0.0022025104,
-0.0051556234,
-0.017709136,
0.010979156,
-0.022505362,
-0.008154854,
0.023319574,
0.025965767,
0.028522905,
0.015826268,
-0.015495495,
-0.03320463,
-0.0013564919,
-0.00813577,
-0.014566783,
-0.017709136,
0.021792924,
0.03735203,
0.002426737,
0.0010933038,
0.0009334827,
0.005231956,
-0.009859613,
-0.012480361,
-0.00782408,
0.00482803,
0.003368171,
0.013358185,
-0.022645304,
-0.008167576,
0.0025873533,
0.06447551,
0.022683471,
-0.0060302666,
-0.011201792,
0.0064596366,
-0.03381529,
0.02689448,
-0.004926626,
-0.012155948,
0.0011203382,
-0.014643115,
0.006965339,
-0.025482329,
0.0066472874,
0.0017874524,
0.019935502,
-0.031016434,
0.002347224,
-0.017047588,
-0.019324841,
-0.007671415,
0.00843474,
0.011825174,
-0.0035303775,
-0.0142614525,
-0.021449428,
-0.00971967,
-0.012931995,
-0.006125682,
0.0006400797,
-0.0025380552,
0.0077922745,
-0.019452062,
0.00892454,
0.0005335323,
0.0070480327,
0.007226142,
0.016920367,
0.011793369,
0.004812127,
-0.0035526413,
-0.026436485,
-0.0055849934,
-0.0057917275,
-0.019388452,
0.0146812815,
0.0118760625,
-0.025176998,
0.00023436459,
-0.0077668303,
-0.013650793,
0.0074805836,
-0.007970383,
0.02127132,
-0.010661104,
-0.01961745,
-0.036385152,
-0.003600349,
0.003997914,
-0.022200031,
0.0029356203,
0.03142354,
0.0013787556,
-0.01179973,
0.00886093,
-0.15846623,
0.009019955,
0.0053464547,
-0.015215609,
0.03498572,
0.021932868,
0.01564816,
0.0015234692,
0.014274175,
-0.012213198,
0.027479695,
0.008262992,
-0.031525318,
-0.009306203,
0.004242814,
-0.005489578,
0.029744225,
0.03483306,
0.024184676,
0.0003919991,
0.018917734,
-0.008033995,
-0.009096288,
0.0055881743,
-0.016640482,
0.013320019,
-0.040888768,
0.016131599,
0.02169115,
-0.0027543306,
-0.030634772,
0.025825825,
0.018701458,
-0.0033554488,
-0.033611737,
0.013192798,
-0.016284265,
-0.033967957,
-0.0037053062,
0.011627982,
0.0019941863,
0.024833502,
-0.0064819003,
0.016475094,
0.009217148,
0.013841624,
0.012168671,
-0.017276587,
0.015062944,
-0.014770336,
0.0063674017,
-0.04363674,
-0.00040034798,
0.005044305,
0.008345685,
-0.020151777,
0.019681059,
-0.008027633,
0.0008754382,
0.025940323,
-0.023739403,
-0.047733247,
0.015419162,
0.040965103,
0.013256408,
-0.020762436,
-0.03429873,
-0.005079291,
-0.02646193,
-0.014363229,
-0.0220092,
-0.0043445905,
0.014134232,
-0.022429029,
0.022734359,
0.0026525538,
-0.009299842,
0.025253331,
0.021576649,
-0.010559327,
-0.0048948205,
0.015877157,
-0.04185565,
-0.006869924,
-0.017518306,
-0.009268036,
0.019884612,
0.008110327,
-0.04185565,
-0.010094971,
0.032237753,
-0.020151777,
0.004176023,
-0.016118877,
-0.005018861,
-0.024808059,
-0.016551428,
-0.009070843,
0.010438467,
-0.014146954,
0.0066472874,
-0.020469828,
-0.014375952,
-0.005057027,
0.025634993,
-0.038191687,
-0.018179854,
0.013498128,
0.03434962,
-0.018256186,
-0.010292164,
-0.0069589783,
-0.020482551,
0.021678425,
-0.007264308,
0.027912246,
0.013587182,
-0.0010471863,
0.0070480327,
0.008670098,
0.068648346,
-0.035723604,
0.019579282,
0.003428601,
-0.0075123888,
0.0029594742,
-0.10396484,
0.012881107,
0.0062878886,
0.023077855,
0.0053814403,
0.022123698,
-0.005635882,
0.023777569,
0.028599238,
0.010139499,
-0.013561739,
-0.02531694,
-0.021729315,
-0.008918179,
0.05674048,
-0.0020100889,
-0.015978934,
-0.026334709,
-0.013498128,
0.038293462,
0.015762659,
-0.007404251,
0.014465006,
-0.00849835,
-0.026563706,
-0.019897334,
-0.0072897524,
0.008078521,
0.0036607787,
0.012613944,
0.0030707924,
0.003533558,
0.004538602,
-0.0071434486,
-0.038420685,
-0.008631932,
-0.031347208,
-0.006755425,
0.00544187,
-0.014490451,
0.008345685,
0.0114498725,
0.01681859,
0.012016006,
-0.013294575,
-0.0029817377,
-0.02096599,
-0.016538706,
-0.00672362,
-0.03478217,
-0.003991553,
-0.02353585,
0.024680838,
-0.008021272,
0.0012141636,
-0.029362563,
0.02024083,
0.0064755394,
0.00082932063,
0.0057122144,
0.00035800732,
0.0131546315,
0.008485628,
0.013459962,
0.011748842,
-0.020380775,
-0.013040133,
-0.007970383,
0.004649921,
-0.006889007,
-0.0390059,
0.01571177,
-0.0011752022,
-0.010616576,
-0.005820352,
0.011010962,
-0.014961167,
-0.017200254,
-0.0030151333,
-0.02176748,
-0.0112781245,
-0.018281631,
0.0024203758,
0.016436929,
0.011831535,
-0.0044781724,
-0.008422018,
-0.011977839,
0.0073215575,
0.0006253698,
0.007951301,
0.054399617,
-0.0024951182,
-0.02261986,
0.015571827,
0.02824302,
-0.022976078,
-0.0030612508,
0.010648382,
-0.0015910553,
-0.03686859,
0.0015457328,
-0.051448096,
0.015215609,
0.009980473,
-0.004665823,
-0.009140816,
-0.006186112,
0.013052856,
0.026512817,
0.0055722715,
0.012073255,
-0.0047676,
0.009687865,
-0.02323052,
-0.0072452254,
-0.011214514,
-0.0050156806,
0.020342607,
0.02915901,
0.027377918,
-0.0066600093,
-0.02781047,
0.001118748,
0.010025,
0.005324191,
-0.019426618,
-0.008288436,
0.01534283,
0.0071116434,
-0.010374857,
0.008046716,
0.003247311,
-0.013561739,
-0.025507772,
0.0006881851,
-0.029846001,
-0.027174365,
0.002194559,
0.009242591,
0.03709759,
0.01834524,
-0.009280758,
-0.006736342,
0.011150904,
-0.01606799,
-0.0012396078,
0.019235786,
-0.00039975165,
0.027861357,
-0.0061606676,
0.005985739,
0.009102649,
0.0066854535,
0.013892513,
-0.024311896,
-0.032517638,
0.0038611516,
-0.013778014,
0.025953045,
-0.016958535,
-0.008549239,
0.013650793,
-0.014274175,
0.0067045367,
0.00050649786,
0.037631914,
-0.02421012,
0.0026382415,
0.0074869446,
-0.0061161406,
-0.016525984,
-0.0047898637,
0.0010797867,
-0.0024744447,
0.013167354,
-0.018434295,
0.006749064,
-0.0030246747,
0.026919924,
-0.023726681,
0.029922334,
-0.007219781,
0.03490939,
-0.047478806,
0.029057233,
0.040328998,
0.00629743,
-0.018205298,
0.0060588913,
0.014350507,
0.00080069597,
-0.028319353,
0.006252903,
0.0032918386,
0.003753014,
-0.01344724,
0.008180298,
-0.0038929568,
-0.01137354,
0.02781047,
-0.007633249,
0.0061606676,
0.017632805,
-0.00984689,
-0.031245431,
-0.007067116,
-0.0071307262,
-0.004878918,
-0.050684772,
-0.0050156806,
0.0045354217,
0.010521161,
0.037123032,
-0.031576205,
0.0016665927,
0.012582138,
0.0070798383,
0.006901729,
0.015928045,
-0.018968623,
0.015928045,
-0.014146954,
0.018179854,
0.010222192,
-0.014604949,
0.028217576,
0.0016347874,
0.0024012928,
-0.018179854,
0.030151332,
-0.020088166,
0.016042544,
-0.010762881,
-0.03857335,
0.0059825587,
0.005018861,
-0.02781047,
0.025698604,
0.0009748295,
0.00929348,
0.038242575,
0.0032886579,
-0.036232486,
0.008460184,
0.015139276,
0.016398763,
0.007162532,
0.0038357074,
0.0005573862,
-0.013434517,
0.018421574,
-0.013930678,
0.014923001,
-0.01882868,
0.0058521573,
0.006933534,
0.0038675126,
0.010985517,
-0.010114054,
-0.012537611,
0.008345685,
-0.03778458,
0.013091021,
0.010037722,
-0.0060175443,
0.01124632,
0.038980458,
0.01351085,
-0.009395257,
-0.014999334,
-0.024833502,
-0.015113832,
0.0035749048,
-0.00892454,
0.03447684,
-0.009331646,
-0.0118760625,
-0.007506028,
0.030074999,
0.014833947,
0.004923445,
-0.0114498725,
-0.02371396,
-0.00868282,
0.0015497085,
-0.015826268,
0.0076459707,
-0.0076459707,
-0.023268687
] |
AIMS Lactic acidosis is a well recognized complication of biguanide therapy which is potentially serious. Although the prevalence of metformin-associated lactic acidosis (MALA) is much lower than that associated with phenformin, it is still being reported sporadically which raises concerns for the practising clinicians. We review the currently available world-wide data of the prevalence of MALA, the risk factors for its development and the current practical guidelines on the use of metformin to minimize the risk of this potential hazard. METHODS An extensive literature search was conducted from both Medline and Ovid (1965-98) using | [
0.0017859872,
-0.03149384,
0.029495899,
-0.050106224,
-0.022069346,
0.016732745,
-0.010574621,
-0.004383637,
-0.011310704,
-0.0065886,
0.003792142,
0.0042686244,
-0.0030823476,
0.0059083807,
-0.005040854,
-0.006434154,
0.045689724,
0.0037001316,
0.002520427,
0.007235959,
-0.0071308045,
0.0076434333,
-0.012815732,
-0.0022296086,
-0.0007147235,
0.0016890477,
0.0017449111,
-0.033991262,
-0.0071505206,
-0.010259157,
0.0038447194,
-0.022227079,
-0.008892146,
0.016851043,
-0.0049258415,
-0.00978596,
0.0149714025,
0.0153263,
0.01223738,
-0.024448471,
0.009562507,
0.01308519,
0.009891115,
0.00681534,
-0.0009997913,
0.007972042,
0.021359552,
-0.0061384067,
-0.0334392,
0.030416002,
0.01159988,
0.016995631,
0.001974937,
-0.0022920442,
-0.00093324814,
-0.0058919503,
0.0022493252,
0.015838929,
0.008780419,
-0.017573982,
-0.02765569,
-0.0014319115,
-0.013564958,
0.008142918,
-0.0028063166,
0.01511599,
0.011047818,
0.023055172,
0.014577073,
-0.009227326,
0.0053201714,
0.021004654,
0.034701057,
-0.0013103264,
0.018283777,
-0.007932609,
-0.02805002,
-0.029942805,
0.0044657895,
0.01650929,
0.027156206,
0.009437636,
-0.0023298343,
0.03727735,
0.009733384,
-0.013893567,
0.009628229,
0.017889446,
-0.004018882,
-0.007945754,
-0.015576042,
0.016588157,
0.037067037,
0.049501583,
-0.0008864214,
-0.0014113735,
-0.010975524,
0.02319976,
-0.0003179287,
-0.0018024176,
-0.00872127,
0.011363282,
-0.026525278,
-0.013433515,
-0.018954137,
0.017481972,
0.0018747115,
-0.006388149,
0.021044089,
-0.0029624056,
-0.0073476858,
0.059675302,
0.012861736,
-0.014866248,
-0.00040542072,
-0.0133480765,
0.028444352,
-0.006565598,
0.012579133,
-0.016588157,
0.011685318,
0.006729902,
-0.0038447194,
0.0039925934,
0.00033867214,
0.0024514194,
-0.0059050946,
-0.023436358,
-0.03583147,
-0.01462965,
0.023239192,
-0.014892537,
0.017639704,
-0.019440478,
-0.0034996804,
0.030862909,
-0.02689332,
-0.013946144,
-0.00016851454,
-0.021793315,
0.0101934355,
0.02677502,
-0.021490995,
0.011475009,
-0.039958794,
0.025762906,
0.017968312,
0.0033633078,
-0.006358574,
-0.0076500056,
0.016614445,
-0.02656471,
-0.017429395,
-0.0024284169,
0.0075251344,
-0.01569434,
0.005560056,
0.019611355,
-0.037540235,
-0.007630289,
-0.010712637,
-0.008537249,
-0.011862767,
0.009306192,
-0.0031562846,
0.020570891,
0.012874881,
-0.03241394,
-0.0029771929,
-0.030337136,
0.005185442,
0.024369605,
-0.0010548333,
0.017048208,
-0.00069665,
0.028917547,
-0.013472948,
-0.011429003,
-0.013223206,
-0.020912644,
-0.0028917547,
0.010462894,
0.0037099898,
0.014011866,
-0.03286085,
0.024448471,
-0.013880422,
-0.0031398542,
0.017652849,
-0.023764966,
0.010955807,
0.03144126,
-0.008313795,
-0.0040123095,
-0.64775306,
-0.011475009,
-0.004879836,
-0.0030790616,
-0.009201038,
0.0025795766,
0.008366372,
-0.007834027,
0.0043672067,
0.019190736,
-0.023856977,
0.033202603,
0.02707734,
-0.033728376,
0.0039531603,
-0.005546911,
-0.0027159492,
-0.021490995,
-0.0018254202,
-0.020584036,
-0.022424243,
-0.006029966,
-0.011731323,
-0.008280934,
-0.011041245,
0.0193879,
0.019440478,
-0.017521406,
-0.006236989,
0.03764539,
-0.025434297,
-0.00033415377,
0.010075136,
-0.015996661,
0.0503954,
-0.03149384,
-0.016890476,
0.002586149,
0.025697185,
0.008103485,
-0.019033004,
0.0030330564,
0.027129916,
0.016653879,
0.011889055,
0.023107748,
0.03917013,
0.007051938,
-0.0018862127,
0.018783262,
0.013814701,
-0.006618175,
-0.0041634697,
-0.0036508404,
0.03385982,
0.016088672,
0.013137767,
-0.0038972967,
0.0062468476,
0.028970124,
-0.02489538,
-0.0033156597,
-0.017166508,
-0.0044296426,
-0.025973216,
0.0149714025,
-0.015707485,
0.0056356355,
0.010278873,
-0.0013234707,
0.029706208,
0.017087642,
0.0073674023,
0.015799496,
0.036488686,
0.013814701,
0.0036935594,
0.043928385,
-0.027340226,
0.00851096,
0.004689243,
0.019282747,
-0.011705034,
-0.030678889,
0.051446944,
0.009503357,
-0.010029132,
-0.00293776,
0.0041568973,
0.001275001,
0.018296922,
0.0132560665,
-0.0004411569,
-0.027208783,
-0.004265338,
0.014274753,
-0.01623326,
0.0060135354,
0.025039967,
-0.021951048,
-0.034333017,
-0.011225266,
-0.002319976,
-0.003057702,
0.0063651465,
-0.012533128,
-0.02577605,
-0.005458187,
0.02928559,
-0.01762656,
0.0013670113,
-0.01760027,
-0.0020077978,
0.0014935256,
0.021530429,
-0.022844862,
-0.0116327405,
-0.010134286,
-0.008070624,
-0.011816761,
0.012763154,
0.030100537,
-0.0052150167,
0.0039663045,
-0.027787134,
0.004189758,
0.026735587,
-0.013354649,
-0.0046169492,
-0.012289957,
0.0012618566,
0.026538422,
0.03238765,
-0.009161605,
0.024211874,
-0.032755695,
0.021398986,
0.011008385,
-0.0005446686,
-0.02150414,
-0.02298945,
-0.011271271,
-0.0092338985,
0.0029081851,
-0.012473978,
-0.022397954,
-0.0019847953,
0.011902199,
-0.019177591,
0.02923301,
0.0017580554,
-0.014274753,
-0.024277596,
0.026104659,
-0.017429395,
-0.021543574,
-0.014169598,
-0.0320459,
-0.0009587153,
0.011133255,
-0.0016808325,
-0.0066773244,
-0.020754913,
0.00039248177,
-0.0070190774,
-0.036883015,
0.008083769,
-0.0006551632,
0.0046268078,
-0.0100094145,
0.0072491034,
-0.033964973,
0.009733384,
0.019348469,
-0.00073156465,
0.026222957,
0.006348716,
0.004804256,
-0.015838929,
-0.011573591,
0.0292593,
0.02538172,
0.00527088,
0.01781058,
0.01920388,
-0.00013401065,
0.0193879,
0.00672333,
-0.011797044,
0.024540482,
-0.03301858,
0.014195886,
0.00736083,
-0.010535188,
0.0012947174,
0.010482611,
-0.010614054,
-0.010226296,
-0.023830688,
0.027392805,
0.04540055,
-0.023226049,
0.012013926,
-0.0072491034,
0.029890228,
-0.010798075,
0.0040451707,
-0.019309035,
0.025907494,
-0.0046596685,
-0.00094557094,
-0.02986394,
-0.011935061,
-0.016312126,
-0.0079983305,
-0.0024530625,
0.006585314,
-0.008280934,
-0.015668053,
-0.014051299,
0.012303102,
-0.0031037072,
0.025500018,
-0.017560838,
0.012631711,
0.0023643381,
-0.0035095387,
0.015221145,
-0.023212904,
-0.011166116,
0.00013637252,
0.013775268,
0.012559417,
0.010863797,
0.016837899,
-0.0075251344,
0.007557995,
-0.0024892094,
0.026367545,
0.0013670113,
-0.011113539,
0.008925007,
0.030547446,
0.010048848,
0.01611496,
0.016759032,
0.033176314,
0.03380724,
0.00041877045,
0.027734557,
-0.018165477,
-0.00757114,
-0.006499876,
0.013223206,
-0.014274753,
-0.014077588,
0.0025220702,
0.020215994,
0.03325518,
0.012467406,
-0.0139198555,
0.00872127,
-0.007827454,
-0.0023298343,
-0.015339444,
0.018967282,
0.024842802,
0.0049751326,
-0.0010104711,
0.010462894,
-0.036383532,
-0.012434545,
0.017179651,
-0.016128104,
0.013459804,
-0.0011378069,
-0.0032696545,
-0.0085701095,
0.035752606,
-0.003440531,
-0.004879836,
-0.052498493,
0.02147785,
0.019769087,
0.007078227,
-0.0013259352,
-0.012894597,
0.0011460221,
-0.0034372448,
0.013486093,
0.0007935895,
0.009463925,
0.014839959,
0.0037099898,
-0.013098335,
-0.007459413,
0.004133895,
-0.008609543,
0.03138868,
-0.008484671,
-0.0040780315,
0.020557746,
-0.025276566,
-0.0046958155,
0.024133008,
0.010712637,
0.0008178244,
0.0047779675,
-0.00495213,
-0.023725534,
-0.013019469,
0.0048962664,
-0.005060571,
0.0063552884,
0.0026551567,
0.02231909,
-0.011731323,
0.008418949,
0.013814701,
-0.022305945,
-0.0019897243,
-0.033623222,
0.014550784,
0.01353867,
0.039511885,
0.015786352,
0.0044789338,
-0.0017005489,
-0.009963409,
0.03238765,
0.014655938,
-0.041299514,
0.026459556,
0.009122171,
0.0021523857,
0.0041930443,
0.0052018724,
0.0058229426,
0.027129916,
0.005619205,
-0.004409926,
-0.039380442,
0.012881453,
0.010528616,
0.01269086,
-0.011974493,
0.029364455,
0.03977477,
-0.0030839907,
-0.012546272,
0.031125797,
0.02517141,
-0.021569861,
0.008898718,
-0.0045873746,
0.004212761,
-0.010528616,
0.02377811,
-0.0039038688,
0.0068284846,
0.0195062,
-0.0063322857,
0.017665992,
0.010430033,
0.035700027,
0.010272302,
0.022148212,
0.01771857,
0.0012363894,
-0.009575651,
-0.024527337,
0.03238765,
0.0155628985,
-0.017534548,
0.04976447,
0.013190345,
-0.0018122758,
-0.017166508,
0.006841629,
-0.0006535201,
0.0028112456,
0.00020383995,
0.0038545777,
-0.012368823,
0.0022591834,
-0.01523429,
-0.0017744858,
-0.010048848,
-0.014458774,
0.020978367,
-0.027787134,
-0.014550784,
0.0029476183,
-0.0045972327,
0.008372945,
-0.020754913,
-0.00096528744,
0.00028137103,
-0.0010375814,
0.015654908,
0.009279904,
-0.034674767,
0.0038775802,
0.027550535,
-0.020965222,
0.029311877,
-0.006654322,
-0.038512915,
0.003716562,
-0.001738339,
0.0137358345,
-0.012822303,
-0.01841522,
0.005188728,
-0.0000558121,
-0.027629402,
0.011323849,
0.008786991,
-0.0181129,
-0.016864188,
0.00070034683,
0.019650787,
-0.022240223,
-0.030521156,
0.00085602514,
-0.025263421,
-0.025026822,
-0.01284202,
-0.005806512,
-0.017192796,
-0.00711766,
-0.014130165,
0.011521013,
-0.020426303,
-0.011823334,
0.0055271946,
0.0014779167,
0.009746528,
0.03378095,
0.026880175,
-0.012421401,
0.004133895,
0.0072622476,
-0.0035292553,
-0.014945114,
-0.02389641,
0.010982096,
0.0005964244,
-0.011041245,
0.027892288,
0.03146755,
-0.022489965,
-0.040353123,
-0.0035884047,
0.023462646,
0.038959824,
0.006795624,
-0.0016430424,
-0.03722477,
-0.0029870511,
-0.019335324,
0.00044896136,
-0.021530429,
-0.012973463,
-0.022187645,
0.0154708875,
0.011120112,
-0.018507231,
0.020045118,
-0.03028456,
-0.017981457,
-0.018165477,
-0.034753636,
0.022056201,
0.006322427,
0.0125922775,
-0.049449004,
-0.0045479415,
-0.016193826,
0.010311735,
0.0017580554,
-0.0049488437,
0.014261609,
0.0249611,
0.024487905,
-0.009168177,
0.009523074,
0.012723721,
-0.013748979,
0.022161357,
-0.023265481,
-0.008195496,
-0.026498988,
0.005037568,
0.008734413,
0.0055206227,
0.013906712,
-0.020189706,
0.01771857,
0.0021178818,
-0.02298945,
-0.03341291,
-0.025486875,
-0.0089578675,
-0.02178017,
-0.003404384,
0.0009644659,
0.0041273227,
-0.04166756,
-0.034122705,
0.034674767,
0.014301041,
0.013906712,
-0.010140858,
0.027787134,
-0.026643576,
0.037382502,
0.039433017,
0.017087642,
-0.0026518705,
-0.026919607,
-0.0014450558,
-0.010568049,
0.0063158553,
0.000849453,
0.008892146,
0.011376426,
-0.019558778,
-0.006463729,
0.023055172,
-0.026117804,
0.0139198555,
-0.0077945935,
-0.041509826,
-0.00634543,
0.0019059293,
-0.00572436,
-0.04561086,
-0.014011866,
0.0072491034,
0.003637696,
0.026591,
-0.0053267437,
-0.019703366,
0.011468437,
-0.00896444,
-0.012184802,
0.002091593,
0.028680949,
-0.0045117945,
0.00011306186,
-0.0132955,
0.0075645675,
0.016614445,
-0.0181129,
0.007400263,
-0.010351167,
-0.017429395,
-0.0043179155,
0.019716509,
0.022660842,
-0.024133008,
-0.030705178,
0.029311877,
0.016522435,
0.0020340865,
-0.016364703,
-0.009437636,
-0.02398842,
0.009030161,
-0.0050934316,
0.020912644,
-0.0026190097,
-0.03564745,
0.010436606,
0.024225017,
0.006230417,
0.0003703007,
-0.008984156,
0.0061844117,
0.004153611,
-0.01913816,
-0.0064867316,
0.020018829,
-0.01208622,
0.02329177,
-0.018822694,
0.013157484,
-0.0066411775,
0.016180683,
0.009023589,
0.0050934316,
-0.0074791294,
0.02726136,
0.00012281742,
0.02289744,
0.022095636,
-0.0025039967,
0.008090341,
-0.0016611159,
0.00525445,
-0.021727594,
-0.02319976,
0.011218694,
0.018441508,
0.019006714,
-0.01593094,
0.005921525,
-0.026814453,
-0.019072438,
0.0037329926,
-0.016298981,
0.010942663,
-0.014734805,
0.0067266156,
-0.034543324,
-0.013709546,
-0.002553288,
-0.0033846674,
-0.0052774525,
-0.007834027,
-0.0015822499,
-0.00030909735,
0.023672955,
0.011698462,
-0.0051525813,
0.009385059,
0.033754665,
-0.03165157,
-0.020018829,
0.012151942,
0.03123095,
-0.028812392,
-0.02226651,
0.012927458,
0.006493304,
0.011948205,
-0.004022168,
0.019703366,
-0.006036538,
0.009431064,
-0.008504388,
-0.015523465,
0.0076894388,
-0.051262926,
0.028996414,
0.02250311,
-0.0008428808,
0.0075185625,
-0.007235959,
-0.0015231003,
-0.013104906,
-0.015444599,
-0.01590465,
-0.0049324133,
0.028128887,
0.0064735874,
0.006618175,
0.00034770885,
-0.0016496147,
-0.029811362,
0.016312126,
0.012033643,
0.0035062525,
-0.022647697,
-0.013867279,
-0.008635831,
0.008090341,
-0.025039967,
-0.006079257,
-0.002870395,
0.011829905,
-0.019979397,
0.0030609882,
-0.028391773,
0.045111373,
-0.019769087,
-0.03725106,
-0.009733384,
-0.01453764,
-0.037145905,
0.002094879,
-0.013196917,
0.008556965,
0.020189706,
0.018835839,
0.005852517,
0.0017711997,
-0.0015411738,
-0.009030161,
-0.0459789,
0.009667662,
0.00875413,
-0.0045446553,
0.050263956,
-0.024593059,
-0.017048208,
0.0026748732,
0.01462965,
-0.012500267,
-0.0067759072,
0.024632493,
-0.0042423354,
-0.016193826,
-0.012723721,
0.00587552,
0.011790473,
-0.0027028047,
0.010706064,
-0.010712637,
-0.0072228145,
0.0076500056,
-0.0020308006,
-0.00220332,
-0.000004967636,
0.00011347262,
-0.006460443,
0.01453764,
0.017245373,
-0.015970374,
-0.015247434,
-0.014563928,
0.012217663,
-0.0016890477,
0.014747949,
-0.016864188,
-0.0017974884,
-0.011829905,
-0.00549762,
0.007505418,
-0.00626985,
-0.0004830545,
0.029417032,
0.007827454,
-0.011402715,
0.010554905,
0.009549363,
-0.0074462686,
-0.015300011,
0.013893567,
-0.013998722,
-0.030678889,
0.029758785,
-0.0044690757,
-0.016141249,
-0.015194857,
0.011461864,
-0.017850013,
0.016088672,
-0.0060266796,
0.017337384,
-0.013985577,
0.004600519,
-0.015510321,
-0.020649757,
0.017363673,
-0.014169598,
-0.02568404,
-0.032308787,
-0.0019387901,
0.16414651,
-0.015852073,
0.004883122,
0.025210844,
-0.018704396,
0.010791503,
0.013696402,
0.007801166,
-0.010804648,
0.0064407266,
0.025223987,
0.008195496,
-0.024133008,
-0.002321619,
0.01363068,
0.01913816,
-0.028128887,
-0.008438666,
-0.005376035,
-0.016772177,
0.00021092557,
0.0009069594,
-0.002865466,
0.014379907,
0.00945078,
0.0009603583,
0.0035949768,
-0.005040854,
0.027866,
0.0069336393,
0.0006888455,
-0.008379516,
-0.012657999,
0.009562507,
-0.004018882,
0.002359409,
0.018073468,
-0.030678889,
0.0017219085,
0.017665992,
-0.006894206,
0.026144091,
-0.025710328,
0.0018057036,
-0.03325518,
0.0024234876,
-0.00065557397,
-0.023738677,
-0.0004247265,
-0.0031990036,
-0.028996414,
-0.010370884,
0.016864188,
0.023751821,
0.019913675,
-0.029942805,
0.0033550926,
-0.0038414332,
-0.023134038,
0.021306975,
-0.013617536,
-0.0015074915,
0.023751821,
0.022148212,
-0.04219333,
0.011106967,
-0.01669331,
0.0037625672,
-0.000047160454,
-0.011534158,
-0.0013826202,
-0.013709546,
0.0003536649,
0.015944084,
0.00068555947,
-0.030784043,
0.0263544,
0.03346549,
0.008524104,
0.00920761,
-0.006394721,
-0.024671925,
-0.011415859,
0.0069599277,
-0.016824754,
-0.027787134,
-0.0057703652,
0.010568049,
-0.018480942,
0.006621461,
-0.010482611,
0.00085027446,
-0.003447103,
0.009588796,
-0.022108778,
-0.0024251307,
-0.0027718127,
-0.0028572509,
-0.007919464,
-0.024763936,
-0.033964973,
0.07760418,
-0.0052511636,
0.003289371,
-0.033150025,
-0.015917795,
-0.035489716,
0.0042390497,
-0.00805748,
0.012309674,
0.00110166,
-0.031283528,
-0.018375786,
-0.036041778,
-0.0011468437,
0.0032565102,
0.02280543,
-0.010377456,
0.016062383,
-0.036593843,
-0.01820491,
-0.013472948,
0.01590465,
-0.00726882,
-0.0017991315,
0.006430868,
-0.003486536,
-0.009523074,
0.0002971853,
-0.014090732,
0.012000782,
-0.01075207,
0.0035489716,
0.0095296465,
-0.019755943,
0.003258153,
-0.029127857,
-0.011468437,
0.025223987,
-0.0018418506,
-0.020741768,
0.01620697,
0.017245373,
-0.025368575,
0.004994849,
-0.029548476,
0.023278626,
0.007932609,
-0.010219724,
0.020873211,
-0.013131196,
-0.006887634,
-0.008997301,
-0.007985187,
0.038907245,
0.01414331,
-0.00579994,
-0.038933534,
-0.0005068786,
0.0292593,
-0.011757612,
0.022752851,
0.039695907,
-0.0004337632,
0.00845181,
0.0071636653,
-0.16467229,
0.028602082,
-0.007097943,
-0.001858281,
0.03927529,
-0.0024727788,
0.008990728,
-0.010758642,
-0.0025631462,
0.0062961387,
0.019190736,
-0.01650929,
-0.017758003,
0.010127714,
-0.02108352,
0.010403745,
-0.013591248,
0.020570891,
0.03501652,
-0.010725781,
0.012250525,
-0.03280827,
0.016483001,
-0.008984156,
-0.003059345,
0.03265054,
-0.011251555,
0.029548476,
-0.027445382,
-0.0058262288,
-0.034122705,
-0.0020455879,
0.028996414,
-0.014195886,
0.014222176,
0.0048864083,
-0.018704396,
0.00574079,
-0.005366177,
0.0019782232,
0.013801557,
0.028733527,
0.010653487,
-0.008622686,
0.0019157875,
0.025881205,
0.027313938,
0.012335963,
0.011705034,
0.008524104,
0.023948986,
-0.0046202354,
0.023002595,
0.028628372,
0.008938151,
0.015576042,
0.0010038989,
-0.0023364064,
-0.011567019,
-0.039433017,
0.0070650824,
-0.038302604,
0.01913816,
0.0196245,
0.018310064,
-0.026814453,
-0.003680415,
-0.009391631,
-0.0030478437,
0.021740738,
-0.01493197,
0.0040057376,
-0.01020658,
-0.002517141,
0.04837117,
-0.0027290934,
0.00018751223,
0.011882483,
-0.0011164474,
-0.0046169492,
-0.028917547,
-0.00031566955,
-0.034148995,
-0.019532489,
0.00046991016,
0.006881062,
0.019755943,
0.0102854455,
-0.015838929,
-0.015917795,
0.0070322216,
-0.037908275,
0.004978419,
-0.04503251,
-0.007071655,
0.015339444,
0.011902199,
0.004577516,
0.008188924,
-0.029495899,
0.0070256493,
-0.010364312,
-0.026827598,
-0.00013534562,
0.013762124,
-0.0010457966,
-0.012335963,
0.00047935764,
0.036698997,
-0.012342535,
-0.009733384,
-0.015681198,
0.013762124,
0.0075251344,
-0.009411347,
-0.0002928723,
-0.012585705,
-0.039485596,
0.0019502915,
-0.0088461405,
0.041089207,
0.006000391,
-0.004994849,
0.0077354438,
-0.01308519,
-0.01750826,
-0.13060217,
-0.035594873,
-0.0018287062,
-0.000058430698,
0.021030944,
0.022253366,
0.007544851,
0.011330421,
-0.0021080235,
0.03383353,
-0.013190345,
-0.030889198,
-0.0046235216,
0.006299425,
0.020544603,
0.010232869,
0.008714697,
-0.016088672,
-0.028181463,
0.023055172,
-0.015392021,
0.002550002,
0.0002969799,
-0.01760027,
0.0028408205,
-0.019217024,
-0.010423461,
0.028523218,
-0.0020455879,
0.037908275,
0.028891258,
0.0006416081,
-0.007978614,
-0.00378557,
0.014248464,
0.008202068,
0.0022690417,
-0.008688409,
0.04014281,
-0.032282498,
-0.020347437,
0.009923977,
0.013164056,
0.004222619,
0.029732496,
-0.013748979,
-0.0032022898,
0.0061844117,
0.01060091,
-0.017823724,
-0.0039334437,
-0.03023198,
-0.021517284,
-0.021832747,
0.02807631,
-0.012736865,
-0.002323262,
0.03246652,
-0.016141249,
0.019151302,
0.007281964,
0.008786991,
-0.0042817686,
0.0018747115,
0.016075527,
0.006585314,
0.0153263,
-0.034122705,
0.011875911,
-0.02465878,
0.0021803174,
0.018362643,
-0.0067759072,
-0.013144339,
-0.033649508,
0.016943054,
-0.013906712,
-0.019913675,
0.003014983,
-0.025329143,
0.0037789976,
-0.01880955,
0.0023134039,
-0.0076960106,
0.01144872,
0.013656969,
0.018034033,
-0.015037125,
-0.002163887,
-0.019677076,
0.006154837,
0.035594873,
0.026972186,
-0.0068350565,
-0.019427335,
0.005845945,
-0.010219724,
-0.04119436,
0.008747558,
0.011310704,
-0.000038996586,
0.004636666,
-0.050816018,
0.0049324133,
0.015405166,
0.0012487123,
0.011218694,
0.0017909163,
0.009325909,
-0.0047089597,
0.00039761627,
-0.0022148213,
-0.03383353,
0.02619667,
-0.007433124,
-0.02126754,
-0.03152013,
-0.017968312,
0.015878363,
0.011271271,
0.02250311,
0.010482611,
-0.011981065,
0.02147785,
-0.004699101,
0.02556574,
0.0071308045,
0.013407227,
-0.022305945,
0.03201961,
-0.017468827,
-0.0053201714,
0.00008425727,
-0.00478454,
-0.011258127,
0.0036278376,
-0.04361292,
-0.0076368614,
0.0010663345,
0.009628229,
0.016469857,
0.037987143,
-0.00796547,
0.024277596,
0.018362643,
-0.015260578,
-0.009739956,
-0.017679136,
-0.025250277,
0.020400016,
0.0042423354,
-0.0119284885,
0.01269086,
0.004183186,
-0.014274753,
-0.038144875,
-0.02465878,
-0.0026518705,
0.0075251344,
0.012191375,
-0.03025827,
-0.0098976875,
0.021346407,
-0.038486626,
0.0057342183,
0.0018073467,
0.016404135,
-0.01523429,
-0.022489965,
-0.0074199797,
0.0046169492,
-0.041457247,
-0.019269602,
0.0153788775,
-0.0034963943,
0.0033945257,
0.023870122,
0.019939963,
0.008806707,
0.022950018,
0.01257256,
0.020360582,
0.035279408,
-0.011567019,
-0.026919607,
0.023318058,
0.013998722,
-0.025710328,
-0.0046235216,
0.0035489716,
-0.019072438,
0.012920886,
-0.019519344,
0.019190736,
-0.028812392,
0.024816513,
0.002591078,
0.019177591,
0.015063413,
0.002901613,
0.007413408,
-0.030573733,
0.0065491674,
0.01562862,
-0.014038155,
-0.015063413,
-0.02447476,
0.006795624,
-0.010890085,
-0.03840776,
-0.0032400796,
0.027997443,
0.026591,
0.02029486,
-0.0032630824,
0.00030252518,
0.0007685331,
0.009588796,
0.01257256,
0.012506839,
-0.0037362785,
0.020426303,
0.0057572206,
0.007899748,
0.008011475,
-0.0047878255,
0.013499237,
0.016798466,
0.019585066,
-0.01859924,
0.01590465,
-0.012184802,
0.024185585,
-0.0068679173,
-0.05076344,
-0.016798466,
0.001081122,
-0.020886356,
0.0058196564,
0.006233703,
-0.00030047138,
0.075343356,
0.0053924653,
-0.010436606,
0.0057572206,
0.023554657,
0.012874881,
0.008405806,
0.003752709,
0.000006514407,
0.005451615,
-0.010114569,
-0.013006324,
-0.0016298981,
-0.037145905,
-0.03583147,
0.01650929,
0.024001565,
0.0069336393,
-0.005836087,
-0.034911364,
0.025158266,
0.0021014514,
-0.002439918,
0.013321788,
-0.0056980713,
-0.01453764,
0.027208783,
0.034911364,
-0.0042784824,
-0.01813919,
-0.013512381,
-0.0049718465,
-0.021398986,
-0.007341114,
0.033912398,
-0.029706208,
0.017271662,
-0.035279408,
0.014892537,
-0.012815732,
-0.0041996166,
-0.008977584,
-0.023239192,
-0.018296922,
-0.03201961,
-0.026420122,
-0.010068564,
-0.013026041,
-0.037697967
] |
Inborn errors of the genes encoding two of the four human JAKs (JAK3 and TYK2) and three of the six human STATs (STAT1, STAT3, and STAT5B) have been described. We review the disorders arising from mutations in these five genes, highlighting the way in which the molecular and cellular pathogenesis of these conditions has been clarified by the discovery of inborn errors of cytokines, hormones, and their receptors, including those interacting with JAKs and STATs. The phenotypic similarities between mice and humans lacking individual JAK-STAT components suggest that the functions of JAK | [
-0.027082067,
0.0010378404,
0.005300516,
-0.02713445,
-0.01947342,
0.019984156,
-0.010934974,
0.011013549,
-0.0204687,
-0.00038100526,
0.0145756,
-0.022223534,
0.009075373,
0.023624782,
-0.0016975402,
0.0041513615,
0.031010801,
-0.0020445783,
0.01650068,
0.017967407,
-0.024200996,
0.03740154,
-0.010456978,
-0.0051466404,
-0.0021460706,
0.025104605,
0.010725441,
-0.042194594,
-0.0182948,
-0.0154137295,
-0.00064455776,
-0.009428959,
-0.008014616,
-0.01718166,
-0.011275465,
0.005349625,
0.013154708,
-0.02266879,
0.0044918517,
-0.0154137295,
0.022289013,
0.018648386,
-0.007680673,
-0.014706558,
0.01280767,
0.017089989,
0.0023883423,
-0.017168565,
-0.02881071,
0.0005074614,
0.015741125,
0.006272877,
-0.02812973,
-0.0072616087,
-0.007582455,
-0.00043297914,
-0.00013586869,
0.0009445329,
0.0025143893,
-0.011111767,
-0.000939622,
-0.0071371985,
-0.028994052,
0.016854266,
-0.0036144345,
-0.003529312,
-0.01423511,
-0.004288867,
-0.031587016,
0.023716453,
0.03737535,
0.012270743,
-0.021804469,
-0.017495958,
0.010771276,
-0.019460324,
-0.0048094243,
-0.0046981103,
-0.017142372,
0.013567225,
0.0073139914,
-0.007471141,
-0.0052579544,
0.016147094,
0.012578494,
-0.022839036,
0.001237551,
0.016016135,
0.009402768,
-0.012473728,
0.008885485,
0.009101565,
0.00047472192,
0.01718166,
-0.014942282,
0.016945936,
-0.011065932,
0.020691328,
-0.00092570775,
-0.018216226,
-0.017744778,
-0.01191061,
0.004013856,
-0.014104152,
-0.02056037,
0.007746152,
0.01023435,
-0.007405662,
0.016291147,
0.013246379,
-0.006181207,
0.029936947,
0.0018104912,
-0.03014648,
0.03674675,
-0.0140779605,
0.005235037,
0.00060813513,
-0.013789853,
-0.0061582895,
0.022040194,
0.039339714,
0.0066199154,
-0.008551543,
0.024410529,
0.006014236,
-0.04580903,
0.0009862757,
-0.025916543,
-0.006371096,
0.027605899,
-0.014169631,
0.02425338,
0.009815285,
-0.024318859,
0.009370029,
-0.0076610297,
-0.0067246817,
0.011013549,
-0.0226426,
0.011517736,
0.017260235,
-0.0035096684,
0.007864014,
0.00918014,
0.009376576,
0.014850612,
0.0026191554,
-0.0001501922,
0.0016557974,
0.013069586,
0.0053299814,
0.016107807,
-0.025536766,
-0.0053921863,
0.031456057,
-0.0056344583,
0.02298309,
-0.021516362,
0.0055395137,
0.0049272864,
0.005110627,
0.004062965,
0.0004898639,
0.027894005,
0.015439921,
-0.012938628,
0.007936041,
0.008414037,
0.016762596,
-0.024462912,
0.010535553,
-0.0077854395,
0.01935556,
0.006921118,
0.018687675,
-0.007818179,
0.027946388,
-0.040308803,
-0.0024996565,
-0.013390432,
0.01913293,
0.009167044,
0.0020429413,
-0.020193689,
-0.017443575,
0.025143892,
0.011439161,
-0.0007513702,
0.006371096,
0.01665783,
0.00072886184,
0.016173285,
-0.018320993,
-0.63069266,
-0.024737922,
0.010882591,
0.006181207,
-0.0041644573,
0.029177392,
-0.0077985353,
-0.0046686446,
0.0029318172,
0.026676098,
-0.0152827725,
0.0086366655,
0.029936947,
-0.026676098,
-0.029701224,
-0.021463979,
-0.00013095778,
-0.03724439,
0.021896139,
0.018150747,
-0.010404595,
0.0056737456,
-0.013200544,
0.004773411,
-0.003347608,
0.0036700915,
0.025287947,
-0.02407004,
0.014091057,
0.043897044,
-0.023572398,
0.01752215,
0.021594936,
0.004459112,
0.04211602,
0.0072681564,
-0.006999693,
0.054321285,
0.009775998,
0.034258552,
-0.029386925,
-0.0066068196,
0.012971368,
0.036196727,
-0.012434441,
0.022996185,
-0.00024022567,
0.011340943,
0.00228685,
-0.004534413,
-0.0054478436,
-0.015623262,
-0.018504333,
-0.008597378,
0.009618849,
-0.0032559377,
0.019276984,
-0.004157909,
0.028103538,
-0.00080989196,
-0.012165977,
0.027658282,
-0.017509054,
-0.0024292667,
0.017469767,
0.017063798,
-0.019551996,
0.006652655,
0.0038501585,
-0.013383884,
0.013285666,
0.03941829,
-0.008145574,
0.02251164,
-0.0018743331,
0.024803402,
-0.0053954604,
0.015610167,
-0.0016124176,
0.0094355075,
0.0036733656,
-0.009140853,
-0.049763955,
-0.0052972417,
0.018438855,
0.0031937326,
-0.013154708,
0.025510574,
-0.01103974,
-0.0011614318,
0.0119826365,
-0.02155565,
-0.028548794,
-0.022655694,
-0.007346731,
0.010142679,
0.015741125,
0.018871015,
0.00018497785,
-0.013619608,
-0.031246524,
-0.024881978,
-0.0027779418,
-0.0012964819,
0.007392566,
0.0040236777,
-0.03635388,
-0.004802876,
0.033472806,
-0.030722693,
0.031429864,
-0.0068490915,
0.012296935,
-0.014313685,
0.00016656192,
-0.01956509,
0.016670924,
0.0062041245,
-0.0020756808,
-0.021843756,
0.00087823556,
-0.0033312384,
0.009134305,
-0.019080548,
-0.002699367,
0.037506305,
-0.025261754,
-0.006272877,
-0.010725441,
-0.010640319,
-0.0013365878,
0.0027419284,
0.017993597,
-0.01677569,
0.020167498,
0.0014364431,
0.024711732,
0.003116795,
0.010934974,
-0.013776758,
-0.024384337,
-0.005988044,
0.002705915,
0.012722548,
-0.016147094,
-0.012912436,
-0.0018694223,
-0.0114457095,
0.0057163066,
-0.0070455284,
-0.0056082667,
0.010136131,
-0.0069014747,
0.018936494,
0.0020134759,
-0.004236484,
-0.00065642584,
-0.011426066,
-0.0053725424,
-0.0039025417,
0.00930455,
0.023231909,
-0.016880456,
-0.013894619,
-0.014248205,
-0.013527938,
0.016016135,
-0.0027975854,
-0.015492304,
-0.031141758,
-0.0059258393,
-0.0026076967,
-0.024371242,
-0.011144507,
-0.017299522,
0.028339261,
0.014785132,
-0.030041713,
-0.0045573306,
0.0008405852,
-0.0023948902,
-0.029125009,
-0.017548341,
-0.011327847,
0.029570265,
0.034310937,
0.008675952,
-0.007949137,
-0.009239071,
0.04633286,
-0.034756195,
0.018412663,
-0.0025340328,
0.017875737,
0.021372309,
-0.010208159,
0.01650068,
0.013292214,
-0.030277437,
0.031456057,
0.006279425,
-0.007922946,
0.021319926,
-0.025471287,
0.009789093,
-0.050890192,
-0.00400076,
-0.025759393,
-0.011635598,
0.007844371,
-0.003460559,
0.021293733,
-0.015675645,
-0.0024800128,
0.033760913,
0.0032297461,
-0.012329674,
-0.00088478345,
-0.014470834,
-0.017220948,
0.003758488,
-0.00505497,
0.020363934,
0.000060926057,
-0.0013423172,
0.018569812,
0.026008213,
0.010889139,
0.013298762,
-0.005048422,
-0.013698183,
-0.0019087095,
0.020940147,
-0.0039123637,
-0.018753152,
0.021280639,
-0.009697423,
-0.021608032,
0.045625687,
0.009867668,
0.012244551,
-0.019669857,
-0.0058636344,
0.006259782,
0.006407109,
-0.0186091,
0.04329464,
0.0078771105,
-0.02679396,
0.029203583,
-0.010581388,
-0.0004362531,
-0.01327257,
0.007890206,
0.00029915667,
-0.019617474,
0.012480276,
0.011825487,
0.04345179,
0.011864774,
0.000883965,
-0.024724828,
0.021804469,
-0.014064865,
0.01032602,
0.01500776,
-0.018255513,
-0.0002224236,
-0.007896754,
0.0102867335,
-0.042927958,
-0.0029629197,
-0.0032870402,
-0.008479516,
0.027160643,
-0.0069735013,
0.023428345,
-0.0043936335,
0.0067181336,
0.012853505,
0.003057864,
-0.03273944,
0.019957965,
0.028155921,
-0.0045376867,
0.0026142446,
-0.010993905,
-0.02561534,
-0.015544687,
0.017888831,
-0.022210438,
0.001318581,
0.027789239,
-0.01423511,
0.0064594923,
0.0046653706,
0.032294188,
-0.030644119,
0.0050811614,
0.0019856472,
0.013154708,
-0.003709379,
-0.02124135,
-0.0097956415,
0.02403075,
0.017482862,
-0.010149227,
-0.015033952,
-0.016906649,
-0.04243032,
0.010083749,
-0.020311551,
0.0010386588,
-0.01894959,
-0.010123036,
-0.00967778,
-0.0031004252,
0.01010994,
0.0023490551,
-0.0076151947,
0.0024439995,
-0.061707303,
-0.010057557,
0.016133998,
0.027317792,
0.020953244,
0.004118622,
0.006888379,
0.0069604055,
0.000500095,
-0.0009977345,
-0.008034259,
0.012971368,
-0.014038674,
-0.007909849,
0.011406422,
0.014968473,
-0.011242725,
-0.004694836,
0.017509054,
0.0012506468,
-0.015099431,
0.0066166413,
0.014693462,
0.012513015,
-0.006711586,
0.02393908,
0.02407004,
0.031325098,
0.009153948,
-0.0070455284,
0.034127597,
-0.0016672561,
-0.024410529,
-0.006777065,
0.009160496,
-0.025327234,
0.018242417,
0.0015354799,
-0.0076741255,
-0.004177553,
0.008060451,
-0.007418758,
0.0026060597,
0.02661062,
-0.0013120332,
0.0076741255,
-0.003056227,
-0.004468934,
0.006528245,
-0.0066068196,
-0.005241585,
0.0059454828,
-0.009874216,
0.028155921,
-0.015610167,
0.0032493898,
-0.022040194,
0.008073547,
0.0009920051,
0.012165977,
-0.010312924,
0.019669857,
-0.016173285,
-0.012689808,
-0.010345664,
0.0040498693,
-0.009965886,
-0.0037257487,
-0.0048749032,
-0.0048552593,
-0.019303177,
-0.03184893,
-0.008603926,
0.016291147,
-0.010136131,
-0.0030365833,
-0.016382817,
0.007647934,
0.011576667,
0.011229629,
-0.0034310936,
0.023428345,
0.037165817,
-0.024659349,
-0.025065318,
0.00716339,
-0.023441441,
0.020796094,
-0.00096008414,
-0.0010984084,
-0.010993905,
-0.00980219,
0.0106861545,
0.018923398,
-0.013252927,
-0.015531592,
0.013377337,
-0.001084494,
0.003961473,
0.011923705,
0.021830661,
-0.014929187,
-0.015636358,
-0.020887764,
-0.03216323,
-0.030879842,
-0.013698183,
-0.021031817,
-0.011897514,
-0.010149227,
0.013423172,
0.00241126,
-0.008518803,
-0.0010640319,
-0.014536313,
0.003526038,
0.004694836,
0.014051769,
0.038370628,
0.011714173,
0.0068621873,
0.015911369,
-0.009782545,
-0.013036846,
-0.027396366,
0.029753607,
0.008433681,
-0.018425759,
0.008427133,
0.012513015,
-0.017509054,
-0.029570265,
-0.02155565,
-0.0092587145,
0.028103538,
0.008040807,
0.0005344714,
-0.024358146,
0.003961473,
-0.036851518,
0.020481795,
-0.0037781317,
-0.014942282,
-0.006921118,
-0.0025176632,
0.0023981642,
-0.014470834,
0.0028335988,
-0.04023023,
-0.022459257,
0.020940147,
-0.0226426,
0.014876803,
-0.012526111,
0.0055395137,
-0.00669849,
-0.032294188,
-0.01702451,
-0.054321285,
0.0064987796,
-0.0047275755,
0.036511026,
0.034965724,
0.019735336,
-0.018740058,
0.019499613,
0.022472354,
0.013331502,
-0.0009887312,
-0.007968781,
0.0011786199,
-0.019394847,
0.01203502,
0.006194303,
-0.006842544,
0.03273944,
-0.0061975764,
0.021673512,
0.002645347,
0.005356173,
-0.022865226,
0.012578494,
-0.051990237,
-0.00065069646,
0.03470381,
-0.00037793594,
0.01618638,
-0.037768222,
0.011399874,
0.014091057,
-0.028417837,
-0.018766249,
0.0010181967,
0.02654514,
-0.030591736,
0.027789239,
-0.022524737,
0.0041382657,
-0.011609406,
0.0030218507,
0.004347798,
0.021594936,
0.012408249,
0.008112834,
0.027998772,
-0.016644733,
-0.0012563762,
0.008355106,
0.00541183,
-0.009199783,
0.00018364782,
-0.009206331,
-0.014274397,
-0.010712346,
-0.012526111,
0.008970607,
-0.039706398,
-0.0068359957,
0.0031446235,
-0.0076741255,
0.007425306,
-0.014706558,
-0.017600724,
0.028208304,
-0.022262821,
0.01327257,
-0.013527938,
0.020193689,
0.020036539,
0.0090360865,
-0.028522603,
-0.018373376,
0.004884725,
-0.0015911369,
0.025916543,
0.029072626,
-0.020625848,
-0.01963057,
0.020887764,
0.01023435,
-0.023860507,
-0.03810871,
0.0031871847,
0.011190342,
0.012624329,
-0.007516976,
0.00989386,
-0.005048422,
0.00800152,
-0.014536313,
0.028732136,
-0.017103085,
0.004269223,
-0.009992078,
0.020010348,
-0.012008828,
0.015138718,
0.013514842,
-0.012611234,
-0.01636972,
-0.023087855,
0.0145756,
0.012565399,
-0.00011039331,
0.020691328,
0.006410383,
0.01060758,
0.0062204944,
-0.011760008,
-0.00241126,
-0.014038674,
-0.0138553325,
0.044708982,
-0.017823353,
-0.01969605,
0.025811777,
0.0021493444,
-0.0002328593,
-0.0027812156,
0.008662857,
-0.038475394,
-0.049816336,
-0.00006998056,
0.015544687,
0.008394393,
0.0014740934,
0.0040957043,
-0.025602244,
-0.022354491,
-0.0043838113,
-0.034860957,
0.005938935,
-0.039523058,
-0.007477689,
-0.0015739488,
0.00033394233,
-0.0029318172,
0.023834314,
-0.013947003,
0.0060338792,
0.037008666,
0.001555942,
0.0136458,
-0.0000546851,
0.014248205,
-0.019276984,
-0.006829448,
-0.007759248,
-0.016723307,
0.018988878,
-0.002885982,
-0.023375962,
-0.01103974,
0.002586416,
0.015767315,
0.015243485,
-0.0076741255,
0.042220786,
-0.018766249,
0.009507534,
-0.0027533872,
-0.008021164,
0.012611234,
-0.017967407,
0.007700317,
0.008047355,
0.01627805,
0.018635292,
0.013947003,
-0.0060731666,
-0.0016263318,
-0.012139785,
-0.009854573,
-0.017810257,
-0.0037257487,
-0.011065932,
0.015256581,
-0.024724828,
-0.026034405,
-0.020429412,
0.024973648,
0.029439308,
0.005107353,
-0.020167498,
0.01752215,
0.0045671524,
0.02964884,
-0.0011000453,
-0.011216533,
-0.0073729227,
-0.009533726,
-0.039732587,
0.023978367,
-0.0101950625,
0.036144346,
0.015819699,
0.012244551,
-0.024620062,
0.00027316972,
-0.022812843,
-0.019460324,
0.0062826993,
-0.008433681,
0.0061582895,
0.024764115,
-0.0008139844,
0.0059160176,
-0.013377337,
-0.0024439995,
-0.02071752,
-0.032634676,
0.011936801,
0.012277291,
0.027160643,
0.0066592027,
-0.00459007,
-0.030356012,
0.039496865,
-0.008407489,
-0.0057392246,
0.010339116,
-0.01665783,
0.003873076,
-0.013043394,
0.02214496,
-0.015688742,
0.0107319895,
0.04245651,
-0.014850612,
-0.010424239,
0.003948377,
0.0004878177,
-0.021594936,
0.022275917,
-0.010306377,
0.018072173,
0.0066133677,
-0.00010619857,
-0.018006694,
0.0011557024,
0.0055231443,
0.025314137,
0.018831728,
-0.01770549,
0.0014577237,
-0.010849851,
0.002758298,
-0.004701384,
0.0022541108,
0.017980503,
0.017849544,
-0.010561745,
0.007582455,
-0.011832035,
0.0033263275,
-0.016945936,
-0.03740154,
-0.011419518,
0.006210672,
-0.011976088,
-0.02980599,
0.012270743,
-0.0138553325,
-0.013239831,
0.0071437466,
0.0064463965,
-0.015701838,
-0.020455604,
-0.004072787,
0.00092816324,
-0.03171797,
-0.0019741885,
-0.003935281,
-0.024947455,
-0.019761529,
-0.0059454828,
-0.021883044,
-0.012892793,
0.011013549,
0.19308414,
-0.018517429,
0.0034736549,
0.016736403,
0.02223663,
-0.0060797147,
0.024790306,
-0.008905129,
-0.008970607,
0.0037159268,
0.028548794,
0.016867362,
0.013776758,
0.0010312925,
0.025222467,
-0.018190036,
-0.023441441,
-0.0097039705,
-0.031377483,
0.009245619,
0.0053430772,
-0.0020249346,
0.011707625,
-0.024947455,
0.035830047,
0.009003347,
-0.025602244,
0.027396366,
0.023179526,
0.0015600345,
-0.03761107,
0.017103085,
0.013816045,
0.0034540112,
-0.008315818,
-0.0058145253,
0.007713413,
0.0021247899,
0.006338356,
-0.008846197,
-0.007949137,
0.017587628,
-0.011282012,
-0.00634163,
0.0080080675,
0.023035472,
0.0024865607,
-0.027501132,
-0.00061018136,
-0.0010100119,
-0.034127597,
-0.0031331647,
0.0050320523,
0.017129276,
-0.014968473,
-0.00600114,
0.021791374,
0.027474942,
0.0053627207,
0.0072550606,
-0.0060731666,
0.007589003,
-0.029936947,
0.0056148143,
-0.02744875,
0.041330274,
-0.023899794,
-0.0056868414,
0.00812593,
-0.018255513,
-0.0013013929,
-0.01448393,
-0.026047502,
0.0062139463,
-0.00041620017,
-0.019957965,
0.03978497,
0.020887764,
0.011308203,
0.009514082,
0.014942282,
-0.00006599044,
-0.0328704,
0.015714932,
-0.026898727,
-0.031089375,
0.027553516,
0.005293968,
-0.023650974,
-0.014588696,
-0.0017515603,
-0.01625186,
0.00087168766,
-0.017430479,
0.018412663,
-0.0015469387,
0.00038673467,
-0.0030464053,
-0.010398047,
-0.018713865,
-0.003977842,
0.06280735,
0.012984463,
0.00022938072,
-0.023991464,
0.02713445,
-0.021608032,
-0.0033361493,
0.0057392246,
0.012427893,
-0.019774623,
-0.010902234,
0.008158669,
-0.00973671,
0.003460559,
0.010810564,
0.02071752,
-0.021175873,
0.016317338,
-0.0031446235,
0.013750566,
-0.016068518,
-0.002774668,
0.039496865,
0.008571186,
0.0056541017,
-0.007052076,
-0.007346731,
0.00055779825,
-0.04400181,
0.019499613,
0.0061386456,
-0.0032559377,
0.014222014,
0.015858985,
-0.02828688,
0.01432678,
-0.016225668,
-0.034991916,
0.029046435,
-0.022014001,
0.00042479427,
0.030722693,
0.016854266,
0.007523524,
-0.028548794,
0.037480116,
0.004354346,
-0.014680366,
-0.0011540654,
-0.004243032,
-0.012041567,
0.0116225025,
0.0016271503,
0.02862737,
-0.02561534,
-0.019709146,
-0.01482442,
0.003817419,
0.020088922,
-0.027422559,
0.028679753,
0.016199477,
0.0031069731,
-0.031403676,
-0.0019741885,
-0.16364484,
0.008302723,
0.010051009,
-0.0028679753,
0.04596618,
0.008551543,
0.0186091,
-0.014182727,
0.024083134,
-0.00097317994,
0.054687966,
0.0043281545,
-0.030225053,
-0.01870077,
0.0016795334,
-0.025641533,
-0.02391289,
0.031429864,
0.016801883,
0.00046735557,
0.044237535,
-0.018347183,
0.027527323,
-0.030513162,
0.007523524,
0.03284421,
0.011242725,
-0.037165817,
0.0025373069,
-0.032896593,
-0.0087217875,
-0.015112527,
0.031927504,
0.004865081,
0.026348704,
-0.0087676225,
0.018753152,
0.0014839153,
0.011655242,
0.004354346,
0.028339261,
0.026440375,
0.01448393,
-0.0078771105,
0.0036144345,
0.00038939476,
-0.009468247,
0.0151911015,
0.03438951,
-0.03171797,
0.026898727,
-0.015453017,
-0.011570119,
0.008905129,
0.05814525,
0.009284906,
-0.011236177,
0.014706558,
0.0017908475,
-0.0021427965,
-0.0055427877,
-0.01684117,
0.031901315,
-0.0067836125,
0.009330741,
-0.0009551733,
-0.008977155,
-0.0047832327,
-0.051597364,
0.010227802,
-0.028784519,
-0.001710636,
0.023808124,
-0.017207852,
0.013043394,
0.0027288327,
-0.021110393,
-0.004996039,
-0.019853199,
-0.015020857,
-0.027082067,
0.00837475,
-0.024737922,
-0.019643666,
-0.021948522,
0.013063038,
-0.0016844444,
0.004337976,
0.013220187,
-0.031508442,
0.008243792,
-0.01423511,
0.004468934,
-0.0013996112,
0.011818939,
0.0051662843,
-0.001939812,
-0.011098672,
0.0046129874,
-0.018242417,
0.007968781,
-0.012179073,
-0.01684117,
0.010051009,
0.023572398,
-0.009500986,
-0.014025577,
0.010640319,
0.040885016,
0.0009551733,
-0.0014487203,
0.011517736,
-0.010384952,
0.02266879,
-0.019944869,
0.031010801,
-0.03465143,
0.0017237316,
0.027370175,
-0.017050702,
0.07108388,
0.013501747,
-0.0050222306,
0.02847022,
-0.014929187,
-0.034415703,
-0.12676713,
-0.0245022,
0.012945176,
0.0020020169,
-0.0122052645,
0.021463979,
0.0012219998,
0.020704424,
-0.020730615,
0.025301041,
-0.019656762,
-0.03232038,
0.010096844,
-0.012702904,
-0.0025045674,
0.006276151,
0.007713413,
-0.015348251,
-0.0137636615,
0.045913797,
0.00707172,
-0.02316643,
-0.008531899,
-0.026898727,
-0.012513015,
-0.000107017055,
-0.04028261,
0.017692395,
0.004128444,
0.037034858,
0.02744875,
0.01057484,
-0.0015011035,
-0.00952063,
-0.0050811614,
0.011930253,
-0.007359827,
-0.028339261,
0.044892326,
-0.006472588,
-0.0032379308,
0.0012596501,
0.03014648,
-0.003118432,
0.0073336354,
-0.0005766234,
-0.03488715,
0.002998933,
0.021516362,
-0.019106738,
-0.01987939,
-0.023454538,
-0.015858985,
-0.031560823,
0.016448297,
-0.013135064,
-0.0057195807,
0.014680366,
0.007582455,
-0.005094257,
0.0060862624,
0.006528245,
0.0104176905,
0.03300136,
0.019551996,
-0.03166559,
-0.017574534,
-0.031639397,
0.047930546,
-0.027474942,
0.0022230083,
0.017063798,
-0.0088134585,
0.000069059766,
-0.009317646,
0.01963057,
-0.023546208,
-0.014012482,
-0.008728336,
-0.02710826,
-0.013108873,
-0.003288677,
0.018517429,
0.0042626755,
0.034808576,
0.021516362,
-0.0057490463,
-0.0038436106,
0.0013930633,
-0.00494693,
-0.009514082,
0.009500986,
-0.01423511,
0.012310031,
-0.011792747,
-0.0012956634,
-0.004642453,
0.00051319075,
0.040073078,
0.02065204,
-0.012100498,
-0.029177392,
-0.048978206,
0.021594936,
-0.011308203,
-0.015204198,
0.014994665,
-0.018726962,
-0.0010918605,
-0.027894005,
0.0058930996,
0.033499,
-0.006940762,
-0.0033885324,
-0.039365906,
-0.0060404274,
-0.0006122276,
0.0011843494,
0.018726962,
0.018975781,
0.014785132,
0.000088191875,
-0.0010263815,
-0.018006694,
0.026767768,
0.017548341,
0.0034245458,
-0.015597071,
-0.011157602,
0.02645347,
-0.0023883423,
-0.014104152,
0.010391499,
-0.025327234,
0.013907716,
-0.009978983,
-0.0182948,
-0.031744163,
0.011602859,
0.025052221,
0.0245022,
0.044447068,
-0.015544687,
-0.027553516,
0.00828308,
-0.016081614,
-0.004347798,
-0.0051531885,
-0.028260687,
0.011563571,
-0.005880004,
0.008662857,
0.025510574,
0.0055886228,
-0.013449363,
-0.026741577,
-0.042587467,
-0.02021988,
0.00375194,
-0.01616019,
-0.0015723117,
-0.015466113,
0.021817565,
0.0072026774,
0.015479209,
0.013737471,
0.008459873,
-0.035463367,
-0.030827459,
0.018399566,
0.017548341,
-0.02012821,
-0.019944869,
0.018373376,
-0.0036046128,
0.002064222,
0.022446163,
0.0004939563,
-0.017587628,
0.014693462,
-0.02074371,
0.015518496,
0.017587628,
0.010077201,
-0.021699702,
0.0017842996,
0.017574534,
-0.008348558,
-0.015308964,
0.034730002,
-0.00087332464,
-0.005189202,
-0.014339876,
0.0017089989,
0.013089229,
0.028941669,
0.01786264,
0.033813298,
-0.008355106,
0.012146333,
-0.01770549,
0.03622292,
-0.023808124,
-0.020835381,
-0.010751633,
-0.037637264,
-0.0126963565,
0.004072787,
-0.043242257,
-0.058878615,
-0.024842689,
-0.015675645,
0.011367135,
0.020887764,
0.009298001,
-0.0001484529,
-0.015728028,
0.007864014,
0.0013324954,
-0.0050975312,
-0.0021247899,
0.017836448,
0.014313685,
-0.012303483,
-0.00032186965,
-0.011543928,
0.024423625,
-0.0034736549,
0.035489555,
-0.02282594,
0.012853505,
0.00412517,
-0.0036864614,
0.0056148143,
-0.0058570863,
0.0046326313,
-0.001266198,
-0.017404288,
0.0011761645,
0.022315204,
-0.021071106,
0.09177521,
-0.0052775983,
0.009396221,
-0.004223388,
-0.03370853,
0.023546208,
0.013266022,
0.011000453,
-0.015858985,
-0.026309416,
0.00011786199,
-0.029544074,
0.021948522,
-0.01804598,
-0.0035587775,
0.0030398574,
-0.0045049475,
-0.00908847,
-0.009854573,
0.000020653984,
0.008950964,
0.008387845,
0.0036308044,
0.019709146,
-0.020835381,
-0.010260542,
0.035961006,
-0.014994665,
-0.00013259475,
-0.020953244,
0.009029538,
-0.004937108,
-0.04028261,
0.0017941215,
0.0020183867,
-0.009095018,
0.009559917,
-0.0027779418,
0.020102018,
0.013226735,
0.017365001,
-0.0032821293,
-0.01969605,
-0.022943802,
-0.0017040881,
-0.011596311,
-0.019617474,
-0.0037290226,
-0.015767315
] |
OBJECTIVE To establish the mental health needs of homeless children and families before and after rehousing. DESIGN Cross sectional, longitudinal study. SETTING City of Birmingham. SUBJECTS 58 rehoused families with 103 children aged 2-16 years and 21 comparison families of low socioeconomic status in stable housing, with 54 children. MAIN OUTCOME MEASURES Children's mental health problems and level of communication; mothers' mental health problems and social support one year after rehousing. RESULTS Mental health problems remained significantly higher in rehoused mothers and their children than in the comparison group (mothers 26% v 5%, | [
-0.0036366656,
0.019537123,
0.007578599,
-0.022191623,
-0.011586894,
0.019205311,
0.017254254,
0.018395688,
-0.012071341,
-0.020147659,
-0.02965077,
0.008023228,
0.001030278,
0.017360434,
-0.017307343,
-0.0009083369,
0.019908754,
-0.015210288,
-0.011805891,
-0.011998342,
-0.020545833,
0.005182912,
0.0019742846,
-0.0041410206,
-0.000045805686,
-0.02078474,
0.035490673,
-0.009768561,
0.008189134,
-0.018754046,
-0.007817504,
-0.007233514,
-0.02322688,
-0.017758608,
-0.020744922,
0.00024512652,
-0.0022778932,
-0.020758193,
0.029040236,
-0.029571135,
0.010876816,
-0.009191208,
-0.009596019,
0.012635422,
0.013272502,
0.009483203,
-0.0022845294,
-0.0075719627,
-0.026545005,
0.0032633764,
0.008215679,
0.026545005,
-0.02646537,
0.017997513,
-0.006778931,
-0.0016623809,
-0.009051846,
0.007910412,
0.009005393,
-0.021289093,
0.0023276652,
-0.0060721696,
-0.02322688,
0.017081711,
-0.018422233,
-0.0053985906,
-0.018754046,
0.0056374953,
0.009078392,
-0.0012650354,
0.043852348,
0.03384488,
-0.00012328911,
-0.01150726,
0.016696809,
0.019829119,
0.008885941,
-0.0037727088,
0.009635837,
0.009476567,
0.011188719,
-0.017944423,
-0.040640403,
0.025761927,
0.012442971,
0.010856907,
0.0061584413,
0.021727087,
0.0034475324,
0.018767318,
-0.016192453,
0.01734716,
0.013285775,
0.0023923686,
0.013498135,
0.023771051,
-0.008335131,
0.022762341,
-0.0029282458,
-0.01517047,
-0.016139362,
-0.020439655,
-0.022417257,
-0.01090336,
0.01570137,
-0.00808959,
-0.025722109,
-0.013670677,
0.00585981,
-0.004675239,
-0.03028785,
0.01161344,
0.0018631276,
-0.023041064,
-0.0021617587,
-0.001586064,
-0.015462466,
-0.019391127,
0.025045212,
0.0031555374,
0.014984655,
0.009483203,
0.021780176,
-0.012170885,
-0.0004608047,
0.00060887606,
-0.040826216,
-0.0030161762,
-0.019059313,
-0.010458732,
-0.03257072,
0.009045211,
0.040720038,
-0.0030792207,
-0.025310662,
0.025058484,
0.0034773957,
0.0008017421,
-0.042843636,
-0.03347325,
0.0050335964,
0.0053421822,
0.0014027376,
-0.012416426,
-0.001228536,
0.013272502,
0.012277065,
0.0074856915,
-0.015887186,
-0.010014103,
0.017426796,
-0.026173376,
-0.016364995,
0.016736625,
0.020970553,
0.017227707,
-0.0052691833,
0.01935131,
-0.046984658,
-0.024713399,
0.0103060985,
0.0060157618,
-0.0049108258,
0.03981751,
0.009463294,
0.008554128,
-0.000046868525,
-0.002299461,
0.010890088,
-0.012522606,
0.008872668,
0.037242644,
-0.046321034,
0.006772294,
-0.0015487351,
0.0048743263,
0.015157198,
0.015688097,
-0.008136044,
-0.020519288,
-0.035490673,
0.038357534,
0.017413523,
0.03246454,
-0.0066428874,
0.0015230196,
0.010465368,
0.011693074,
0.016073,
-0.0013936127,
0.013338865,
0.023558691,
0.00734633,
-0.009536293,
-0.6430262,
-0.0043235174,
0.0013994195,
-0.008109499,
0.0010684364,
0.022921612,
0.022974702,
0.015449192,
-0.034402326,
0.022138534,
0.03251763,
0.00654998,
0.0005636666,
-0.025204482,
-0.019112403,
-0.01570137,
-0.011082539,
-0.007552054,
0.0358623,
-0.013484863,
-0.019762756,
0.018448777,
0.0004873497,
-0.003935297,
-0.0012277064,
0.0147988405,
0.016165908,
-0.02375778,
-0.012542515,
0.014082125,
-0.01209125,
0.032199092,
0.0016897555,
0.033021986,
0.039605148,
-0.028880965,
-0.0129672345,
0.031482376,
0.021315638,
0.019523852,
-0.026637912,
-0.014918293,
0.015674826,
0.020771466,
0.0012592287,
0.0147988405,
0.01140108,
0.009728745,
0.02324015,
-0.005471589,
0.0014964746,
-0.004748238,
-0.015794277,
-0.013372046,
0.008374949,
-0.023731234,
0.00407134,
-0.008720034,
-0.0008859395,
0.008122771,
-0.008733307,
-0.0037494819,
-0.018807136,
-0.023571964,
-0.006208213,
0.02158109,
-0.010976359,
-0.002427209,
0.012277065,
0.0062181675,
0.007950229,
0.041224394,
-0.01543592,
0.004492742,
0.028031524,
0.0022596435,
0.021926174,
0.0055545424,
-0.009914559,
0.0039021156,
0.01724098,
-0.011182084,
-0.015727915,
-0.014413938,
0.0121576125,
-0.025695564,
0.0078042313,
0.006002489,
-0.016749898,
-0.0003241394,
-0.011965161,
-0.004466197,
-0.0121576125,
-0.036180843,
-0.0055678147,
0.03825135,
-0.015369558,
0.02434177,
0.03411033,
-0.01745334,
-0.006516799,
-0.01458648,
0.020306928,
0.023359604,
-0.01171962,
0.0017901288,
-0.00692161,
0.018262964,
0.033499796,
-0.011016177,
-0.0150510175,
0.012217338,
-0.0021435092,
-0.013232685,
0.005899627,
-0.030898385,
0.038755707,
-0.0024554129,
0.007054335,
-0.0050568236,
0.020532561,
-0.00065491506,
0.007751141,
0.0015918708,
0.02158109,
0.027978435,
-0.0028187477,
0.0018730819,
0.0075918715,
-0.0062214853,
-0.0021800085,
0.0048743263,
0.034986317,
-0.0155421,
0.03087184,
0.002296143,
0.012423063,
-0.031800915,
-0.0039187064,
-0.05218748,
-0.01633845,
0.017081711,
0.01734716,
-0.008129408,
-0.019284947,
-0.050090425,
0.0046619666,
-0.0009970968,
-0.017174618,
0.002427209,
-0.014520118,
-0.013000417,
-0.00830195,
-0.0018996269,
-0.0073065124,
-0.02391705,
0.0034010787,
0.00092326844,
-0.0015180424,
0.001768561,
0.01623227,
0.041542932,
-0.009503112,
-0.015157198,
-0.023425967,
-0.0005935297,
0.00354044,
0.020147659,
0.006705932,
-0.03097802,
-0.017386978,
-0.031800915,
-0.034880135,
-0.011925343,
-0.0023940275,
0.0095694745,
-0.014825385,
-0.0024288679,
-0.0073396936,
0.014095398,
0.004960598,
0.0054317717,
-0.03023476,
-0.017705519,
0.021156369,
0.0008519287,
0.010982996,
0.0035570306,
0.027009543,
0.015980093,
0.0039784326,
0.045418505,
0.0062314398,
0.029624226,
-0.0005454169,
0.0031074246,
-0.011354626,
0.020877646,
0.01432103,
0.015263378,
0.003968478,
-0.01945749,
0.014135215,
0.012316883,
0.01389631,
-0.02158109,
-0.0058764005,
-0.0087067615,
0.005411863,
-0.02747408,
0.0009323933,
-0.04974534,
-0.0053786817,
-0.0075056003,
-0.020665286,
0.01639154,
-0.006238076,
0.036738288,
-0.033234347,
-0.009177935,
0.003197014,
-0.01580755,
0.02455413,
0.016431358,
-0.003326421,
-0.015250105,
0.008507674,
-0.0027158859,
0.021116551,
0.015130653,
0.020227294,
0.024925759,
0.003908752,
0.019298218,
0.008627127,
0.01325923,
0.04005641,
-0.019205311,
-0.004296973,
0.013644133,
0.02180672,
0.052373294,
-0.007996683,
-0.017665701,
0.0025831608,
-0.0118523445,
0.022629617,
0.029677315,
-0.0057901293,
0.028615516,
-0.009901287,
0.008374949,
-0.030951476,
0.0036499382,
0.013710495,
0.0042671096,
-0.0010145169,
-0.009761926,
0.0074193287,
0.031694736,
0.008899213,
0.026651185,
0.0024404814,
-0.003968478,
0.01586064,
0.0058631278,
-0.009688927,
0.0029531317,
-0.012814601,
-0.030208215,
-0.0075985077,
-0.015581918,
0.008866032,
-0.017519703,
-0.0041111577,
0.010691001,
-0.0016184158,
-0.0009539611,
0.031986732,
0.004934053,
-0.029995855,
0.011002905,
-0.000113231035,
0.03188055,
0.012396517,
0.000587723,
-0.0009929491,
0.02556284,
0.003885525,
-0.008713398,
0.008554128,
0.0072003324,
0.0031737871,
-0.009038574,
-0.013776857,
0.0080962265,
0.01463957,
0.009224389,
0.018926589,
0.0006586479,
0.012522606,
0.012900872,
-0.03246454,
-0.018103693,
0.0130203245,
0.0066893413,
-0.010385733,
-0.0273679,
-0.037640817,
-0.0015877231,
0.021833267,
-0.0026362508,
-0.0034043968,
0.0054052267,
0.0069282465,
-0.015369558,
-0.02168727,
0.0009191208,
0.029730406,
0.004801328,
-0.0064471182,
-0.038596436,
-0.020081297,
0.01591373,
0.09880051,
0.004038159,
0.010253008,
0.015236833,
0.028137704,
-0.010883452,
0.0017104937,
-0.016842805,
-0.0001933845,
0.003908752,
-0.010830362,
-0.02037329,
0.020439655,
-0.007817504,
0.012396517,
0.021859812,
0.0039518876,
-0.00016507675,
0.001373704,
-0.012296974,
-0.0049041896,
-0.009191208,
0.02322688,
0.04640067,
0.0064802994,
-0.010034012,
0.02561593,
0.02556284,
0.007790959,
-0.018900044,
-0.015369558,
0.0040016593,
0.006636251,
0.03050021,
-0.008945666,
0.0029216097,
0.013159686,
-0.0044827876,
0.009708836,
0.00089174625,
0.01956367,
0.013975945,
-0.0036997101,
-0.013936128,
0.026014104,
-0.009078392,
0.015648281,
0.026704274,
0.0024902532,
-0.009005393,
0.039737873,
-0.014918293,
0.0031522193,
-0.019311491,
0.014679387,
0.018488595,
0.014944837,
-0.010598093,
-0.010478641,
-0.0036798012,
-0.021249276,
-0.015781006,
0.013697223,
-0.00030423063,
-0.017519703,
-0.03511904,
-0.016975531,
0.015024473,
-0.013829947,
0.0020207386,
-0.005385318,
0.0021003736,
-0.022563254,
0.012582332,
0.012011615,
0.008839486,
0.020506017,
0.025469933,
-0.0057768566,
0.039180428,
-0.03326089,
-0.020214021,
0.00692161,
0.0052658655,
0.0032169227,
0.0011829118,
0.016404813,
-0.012582332,
-0.014307758,
0.02497885,
-0.02832352,
0.009914559,
-0.0018116966,
0.0019361263,
-0.018608049,
0.018329326,
-0.010996268,
0.014905021,
-0.0057469937,
-0.012429698,
0.012482788,
-0.026876817,
-0.025602657,
-0.0052725016,
0.002511821,
0.008627127,
-0.03780009,
0.014135215,
-0.0030360848,
-0.029199505,
0.03156201,
-0.05744339,
0.004217338,
0.011215265,
0.022523437,
0.0021816676,
-0.020253839,
0.028509336,
0.038065538,
0.009888015,
0.010160101,
-0.01543592,
0.016564082,
0.016431358,
-0.033446707,
0.014958111,
0.02333306,
-0.01936458,
-0.01617918,
0.0034740774,
-0.015369558,
0.018647866,
-0.01782497,
-0.033712156,
-0.004170884,
-0.013617587,
-0.0009182913,
0.013564497,
0.011414352,
-0.014931565,
0.0042405645,
-0.0187275,
-0.028721696,
-0.020811284,
0.024089592,
-0.02101037,
-0.017466614,
0.017997513,
-0.01968312,
0.022045627,
-0.02853588,
0.017041894,
-0.034667775,
0.022682706,
-0.02243053,
-0.036207385,
0.015316468,
-0.004413107,
0.01904604,
0.0033728746,
0.037242644,
0.020519288,
0.000032999797,
-0.008481129,
0.008155953,
-0.00596599,
0.019722939,
0.017652428,
0.0026097058,
0.016590629,
0.0026843636,
0.015104108,
-0.008341768,
-0.009164663,
0.00654998,
0.03060639,
-0.010896725,
-0.007691415,
-0.0041343844,
-0.026664458,
0.0053687273,
-0.0090850275,
-0.024209045,
-0.008806305,
-0.023704689,
0.0017320616,
-0.0033844882,
0.008633763,
0.0024885943,
-0.0069547915,
0.009815016,
-0.023731234,
0.02466031,
-0.0149979275,
-0.0138830375,
-0.0026196602,
-0.010067193,
-0.02811116,
-0.022934884,
0.008069681,
0.016033184,
0.031986732,
-0.0050667776,
-0.008534219,
-0.013391955,
0.01283451,
-0.034853593,
-0.005766902,
-0.021527998,
-0.023306515,
0.011427624,
-0.008879304,
0.0021053506,
-0.028721696,
0.008666944,
0.0026296144,
-0.006735795,
0.032915805,
-0.010246372,
-0.0029763586,
-0.019855663,
-0.015940275,
0.008262132,
-0.01957694,
0.006394028,
0.0021318956,
-0.011447533,
-0.03140274,
0.0065931156,
0.0068486114,
-0.008288678,
0.044091254,
0.028031524,
-0.023784325,
0.011965161,
-0.0015694734,
0.011500623,
-0.008753215,
-0.026491914,
0.005604314,
0.028403156,
-0.009018665,
-0.00793032,
-0.008335131,
-0.031588554,
0.015011201,
-0.014838657,
-0.013053506,
-0.012529242,
-0.008992121,
-0.004595604,
0.037322275,
-0.03411033,
0.018992951,
0.012230611,
0.0010924928,
0.014944837,
-0.025111575,
-0.02731481,
0.0005226048,
0.0047681467,
0.0438258,
-0.03363252,
-0.006579843,
0.017532976,
0.00045292414,
-0.019192038,
-0.0037328913,
-0.016418086,
0.023797598,
-0.0084744925,
-0.026478643,
0.0017669019,
0.016139362,
0.01294069,
0.01028619,
-0.0013811698,
-0.021501454,
-0.038543347,
-0.0023011202,
0.0061849863,
0.027288266,
0.0027905437,
-0.017546248,
-0.008282041,
-0.0023343014,
0.008826214,
-0.03034094,
0.012018251,
-0.0052393205,
-0.015741188,
-0.007897139,
0.002324347,
0.01956367,
-0.00059601833,
-0.008116135,
0.000858565,
0.02667773,
-0.01915222,
0.017586065,
0.014838657,
-0.0013438408,
-0.009370387,
0.022881795,
-0.006264621,
-0.009781835,
0.01633845,
-0.003011199,
-0.026332645,
-0.007193696,
-0.007711324,
0.027341355,
-0.017267525,
-0.019404398,
0.0120315235,
0.018342597,
-0.0101269195,
-0.0050004153,
-0.020970553,
0.025217755,
-0.018090421,
-0.0046420577,
0.009934468,
-0.023479057,
0.027553715,
-0.011892162,
0.031535465,
0.006317711,
-0.038410623,
0.008016592,
0.0044230614,
0.002193281,
-0.020771466,
-0.012615514,
-0.033951063,
-0.014679387,
-0.00016715057,
0.020054752,
0.011002905,
-0.010518458,
0.006503526,
0.007890503,
0.013252594,
-0.023001246,
0.0051132315,
-0.016670262,
-0.005916218,
-0.01740025,
-0.038755707,
-0.01755952,
-0.016059728,
0.043852348,
0.01511738,
-0.025868107,
-0.0032550811,
0.0060091256,
-0.06450436,
0.020014934,
0.0054616346,
0.011075904,
0.018528413,
-0.008467857,
0.0073330575,
0.035357945,
0.004652012,
0.0342696,
-0.01835587,
-0.021090006,
0.02343924,
-0.011155538,
0.0252443,
-0.0012890918,
-0.023532147,
0.012987143,
0.00761178,
0.00091497315,
-0.0032086275,
0.015369558,
-0.0021451681,
-0.010399005,
-0.020506017,
0.016789716,
0.0065864795,
-0.035251766,
-0.018714229,
-0.016617173,
0.0028618833,
0.022204896,
-0.025058484,
-0.006254667,
-0.013962672,
0.024885941,
-0.020612197,
0.00038925762,
-0.02641228,
0.0119784335,
0.0052990466,
-0.030898385,
0.02795189,
0.0009207798,
0.009197844,
0.011221901,
0.0009946082,
-0.007923684,
0.007054335,
0.024222316,
-0.018886771,
-0.013232685,
0.005597678,
-0.026000833,
-0.010664456,
-0.017572794,
-0.02079801,
-0.013710495,
0.013484863,
-0.013491498,
-0.0066462057,
-0.015303195,
0.0034574869,
0.015011201,
-0.021090006,
-0.017586065,
-0.008082954,
-0.012489425,
-0.016192453,
-0.005365409,
-0.007737869,
-0.0348005,
0.0035338039,
-0.0029448364,
-0.00681543,
0.023094155,
0.012011615,
0.007213605,
0.0076781427,
0.0027324765,
0.2003617,
0.003878889,
-0.005249275,
-0.00008663419,
-0.0090850275,
-0.01633845,
0.026531732,
0.0040282044,
-0.017041894,
0.03984405,
-0.00017990463,
-0.0118523445,
0.003248445,
0.0075255088,
0.0035205313,
-0.018010786,
-0.0023143927,
-0.013557862,
0.000752385,
0.003802572,
-0.0069415187,
0.0072268774,
0.0047681467,
-0.015396103,
0.031057656,
0.007532145,
-0.02343924,
0.0053488184,
0.0049771885,
0.0032235591,
-0.008739943,
-0.013299047,
0.0135777695,
0.018754046,
-0.007007881,
-0.015900457,
0.0052061393,
-0.024859397,
-0.0020257158,
-0.007810868,
-0.0011820822,
-0.0010576525,
-0.010080466,
0.0032351725,
0.0048179184,
0.034189966,
-0.0108635435,
-0.003490668,
-0.016457902,
-0.003885525,
-0.024779761,
-0.006364165,
-0.005654086,
-0.0061949403,
-0.023558691,
-0.0018531731,
0.009615928,
0.009987558,
-0.01209125,
0.007127334,
0.010239735,
0.022656161,
-0.017586065,
0.03188055,
-0.011248446,
0.005756948,
-0.0051862304,
-0.014878475,
-0.021926174,
0.008388221,
0.01474575,
0.0021567817,
-0.01924513,
0.00830195,
-0.0043168813,
-0.006257985,
0.035888847,
0.031854007,
0.015210288,
0.041250937,
-0.024726672,
-0.012204066,
-0.026704274,
0.016882623,
-0.016630445,
-0.00846122,
0.009615928,
0.008720034,
-0.023107426,
0.00011354211,
0.012104522,
0.0032882625,
0.001977603,
-0.011228537,
0.006257985,
-0.0026345917,
0.017519703,
0.013239321,
-0.0016731648,
-0.0013604315,
-0.022470346,
0.07491,
0.010909997,
0.010823726,
-0.0044562425,
-0.024288679,
0.010797181,
0.00830195,
-0.0034707594,
-0.00686852,
0.025708837,
-0.042843636,
-0.0116532575,
-0.014851931,
0.014294486,
0.022403983,
-0.006530071,
-0.02089092,
0.010989632,
-0.0009182913,
0.008481129,
-0.019231856,
-0.0034773957,
0.038649525,
-0.017068438,
-0.02343924,
-0.034508508,
-0.010166737,
0.0036764832,
-0.023412695,
0.002481958,
-0.035782665,
0.0032268772,
0.010279553,
-0.015011201,
0.007266695,
0.013299047,
0.016909167,
-0.011162175,
0.0027540443,
0.020638742,
-0.021076733,
0.00070800504,
-0.00729324,
-0.008939031,
-0.04507342,
0.017546248,
0.024315225,
-0.021355456,
-0.012077977,
-0.015183743,
0.0029995856,
0.01750643,
-0.042949818,
0.010876816,
-0.03647284,
-0.01453339,
-0.036685195,
0.0069282465,
0.004409789,
-0.019497305,
0.016656991,
-0.007737869,
0.026903363,
0.0008477811,
0.018501868,
-0.16787061,
0.013723767,
0.024222316,
-0.0058764005,
0.0044496064,
-0.02280216,
0.0138830375,
0.014732477,
-0.017599339,
0.011314808,
0.018170055,
-0.0044695153,
-0.031429287,
0.016988803,
-0.015515556,
0.0051862304,
0.0069348826,
0.012336791,
0.004671921,
0.002747408,
0.019696394,
-0.021368729,
0.0068220664,
0.009483203,
0.017652428,
0.0016880964,
-0.024739945,
0.03368561,
-0.0073994203,
-0.031588554,
-0.011898799,
-0.01639154,
0.04640067,
0.00338117,
-0.011746164,
0.0024023228,
-0.0026047286,
0.007857322,
-0.0039485693,
-0.005358773,
0.0241825,
0.008348404,
-0.006367483,
0.015674826,
0.0047216928,
0.017771881,
0.02784571,
-0.018820409,
-0.017957697,
-0.007711324,
-0.013458317,
-0.022974702,
0.026292827,
-0.0092111165,
0.01644463,
-0.007638325,
-0.0043500625,
0.018767318,
0.0142413955,
-0.002138532,
-0.03501286,
-0.020320201,
0.025854835,
0.01090336,
0.021501454,
-0.038755707,
-0.0017337207,
-0.010677728,
-0.038676072,
0.017227707,
-0.020877646,
-0.014719205,
0.0060356706,
-0.00088345096,
0.0018531731,
0.02784571,
-0.008481129,
-0.0116532575,
0.026876817,
0.008680217,
0.008235588,
0.016856078,
-0.05882373,
-0.0031090837,
-0.01724098,
0.012681876,
0.0020124433,
0.010704273,
-0.010830362,
0.010239735,
0.02037329,
-0.050674412,
0.0057635843,
0.00911821,
0.025921198,
0.02561593,
0.009828288,
-0.0073264213,
0.027288266,
-0.01601991,
0.022616344,
-0.022496892,
-0.0028635424,
-0.0033131484,
0.014958111,
-0.026491914,
-0.020638742,
-0.0050369147,
0.012376608,
-0.009450022,
-0.02832352,
-0.0048510996,
0.005438408,
0.004894235,
0.008733307,
0.021315638,
0.022058899,
-0.00761178,
0.013531316,
0.006430527,
0.035357945,
-0.005196185,
-0.009761926,
0.0075056003,
0.017201163,
-0.010292825,
-0.118815444,
-0.012861054,
-0.0042405645,
0.00057403574,
0.008487766,
0.016670262,
-0.010027376,
-0.006121942,
-0.00545168,
0.0155421,
-0.023585238,
-0.009934468,
-0.0011140606,
-0.01469266,
0.043560352,
-0.015475738,
0.01299378,
-0.022496892,
0.0039518876,
0.034720868,
0.0031157199,
-0.02609374,
-0.00001896257,
-0.028031524,
-0.0020987145,
-0.005680631,
-0.04053422,
0.004525923,
0.007100789,
0.024368314,
0.00089423486,
-0.0011995024,
0.026823727,
-0.0048710085,
-0.011195356,
-0.011951888,
-0.007206969,
-0.0138830375,
0.029518045,
-0.014825385,
0.006652842,
0.0023641645,
0.020824557,
-0.0073065124,
-0.008952303,
-0.026040649,
-0.010047284,
-0.016351722,
0.00936375,
-0.008812942,
-0.021129824,
-0.00729324,
-0.0002140191,
-0.01532974,
0.022470346,
-0.02933223,
-0.0031356288,
0.009304024,
-0.020930735,
-0.005046869,
-0.021926174,
0.017811699,
-0.02901369,
0.037534636,
0.011712983,
-0.0118258,
-0.014772295,
-0.016550811,
0.011527169,
-0.01883368,
-0.01813024,
0.009688927,
-0.01150726,
-0.006530071,
-0.030792207,
0.008859395,
-0.022284532,
-0.023041064,
-0.0059593534,
-0.009111573,
-0.008647035,
-0.01813024,
0.0369241,
-0.021514727,
0.010193282,
-0.023492329,
0.012549151,
-0.009111573,
0.0036897557,
-0.00031854006,
0.021501454,
0.041914564,
0.016258815,
-0.030898385,
0.03034094,
-0.004014932,
-0.026186647,
-0.011434261,
0.011135629,
-0.017678972,
-0.033552885,
-0.00065284123,
-0.05600996,
0.021833267,
0.005358773,
-0.032809626,
-0.0035470764,
0.002588138,
0.015502282,
-0.026491914,
0.0030294487,
0.022682706,
-0.035888847,
0.03405724,
-0.014719205,
-0.0064802994,
-0.016749898,
0.004419743,
0.022085443,
0.0014467028,
0.006543344,
0.04491415,
0.0050302786,
-0.0048842807,
0.01294069,
0.030048946,
-0.013113232,
0.010352552,
-0.012323518,
0.02996931,
-0.018714229,
-0.0043135635,
0.0150510175,
-0.01522356,
-0.011241809,
0.0017005394,
-0.00665616,
-0.016205726,
0.018475324,
0.01957694,
0.02890751,
0.025523022,
-0.02784571,
-0.021527998,
-0.0017785153,
-0.017307343,
0.00401825,
0.0066627963,
-0.00486769,
0.016802989,
-0.0038987976,
-0.00203567,
0.019988388,
0.0066661146,
0.0058299466,
-0.01729407,
0.0124097895,
0.006264621,
-0.020439655,
0.026292827,
-0.018900044,
-0.0015197016,
0.030022401,
-0.006994609,
0.00401825,
0.009834925,
0.0096292,
-0.012582332,
0.022815432,
0.01601991,
0.002191622,
-0.020452926,
-0.022974702,
-0.008746579,
0.00073081715,
0.01416176,
-0.020665286,
0.012821238,
-0.005873082,
0.0058797183,
-0.010067193,
0.03225218,
0.0099477405,
0.010704273,
-0.0061451686,
0.012987143,
0.018302782,
0.027659895,
-0.0036864376,
0.00946993,
-0.0069547915,
-0.0075653265,
-0.0075454176,
0.00649689,
0.014254668,
-0.0067026136,
0.0030427212,
0.049240984,
0.008965575,
-0.006002489,
0.018767318,
-0.0048046457,
-0.01085027,
-0.011142266,
-0.01580755,
-0.045312323,
-0.00906512,
0.019948572,
-0.010744091,
-0.02466031,
-0.015104108,
0.018435506,
-0.011069267,
0.008182498,
-0.007047699,
0.0035603489,
-0.01315305,
0.033340525,
0.0050369147,
-0.012144339,
-0.014679387,
0.019656576,
-0.022470346,
0.029703861,
0.0063575287,
-0.009071755,
0.022709252,
0.016869351,
-0.0029680633,
0.0070410627,
0.0063608466,
0.007784323,
0.014148488,
0.00401825,
-0.026425552,
0.0046354216,
0.0004545832,
-0.023306515,
-0.0015935298,
0.009795107,
-0.0015462466,
0.05600996,
-0.004014932,
0.00071298226,
0.0023475739,
0.011892162,
0.0092642065,
-0.0034508507,
0.022921612,
-0.0100008305,
-0.0075255088,
0.01527665,
-0.0095694745,
0.019059313,
-0.01936458,
-0.010763999,
-0.006895065,
-0.015873913,
0.0048311907,
0.012655331,
0.01049855,
0.003935297,
-0.025217755,
0.018276235,
0.01649772,
-0.026491914,
0.004622149,
0.0061451686,
-0.017440068,
-0.017572794,
-0.007903775,
0.006420573,
0.012476152,
-0.035968482,
-0.0129473265,
0.023877231,
-0.021939447,
-0.014400665,
0.0064802994,
0.0046851933,
0.0074060564,
0.0027142267,
0.0025864788,
-0.02519121,
-0.0063309837,
-0.00846122,
-0.030632935,
0.006759022,
-0.017758608,
-0.009509748
] |
The possible role of motor development on psychological function is once again a topic of great theoretical and practical importance. The revival of this issue has stemmed from a different approach to the topic, away from Gesell's interest in the long-term prediction of psychological functions from early motoric assessments, toward an attempt to understand how the acquisition of motor skills orchestrates psychological changes. This paper describes how the acquisition of one motor skill, prone locomotion, has been linked to developmental changes in an infant's ability to regulate posture based on information available in patterns of optic flow. It is argued that the onset of prone locomotion presses the infant to differentiate spatially | [
-0.0071157976,
0.009607966,
0.035913464,
-0.02767619,
-0.036411896,
0.015359629,
-0.005167971,
0.012146044,
0.005941855,
-0.027203988,
-0.0034824777,
0.010867167,
0.015556379,
-0.0042727576,
-0.007653581,
0.003679228,
0.039822232,
0.0061156508,
0.0012206708,
0.003154561,
-0.0094243325,
-0.016710646,
-0.0004594936,
-0.0438884,
-0.024410136,
0.009273491,
0.011214759,
-0.032109626,
0.004394087,
-0.009378424,
0.01654013,
-0.009706341,
0.018599449,
-0.033263892,
0.00035271564,
-0.022272117,
0.0021626123,
-0.004584279,
-0.0041284743,
-0.0069387225,
0.010939308,
0.009129208,
-0.024108453,
-0.029906023,
0.0037841613,
0.0076666977,
0.0010468748,
-0.019465148,
-0.026587505,
0.026495688,
0.0057451045,
0.027781123,
-0.015661312,
0.013510178,
0.0016207295,
-0.010978659,
0.012539543,
0.0057188715,
0.017878031,
-0.02932889,
0.005384396,
0.008361882,
-0.008479931,
0.011155734,
-0.015936762,
0.013411802,
-0.0030397899,
0.012329676,
0.008414349,
0.012349351,
0.026062837,
0.014625095,
0.0070567722,
-0.002411829,
0.0433375,
0.0011911582,
-0.010178542,
-0.007128914,
-0.005482771,
0.012775644,
-0.0015010397,
-0.024764286,
-0.025236487,
0.035467494,
-0.010572042,
-0.022678735,
0.019137232,
0.026797371,
0.003931724,
-0.0016772951,
-0.013824978,
0.012100135,
0.023360802,
-0.004315387,
0.009522708,
-0.002518402,
-0.015910529,
0.018402698,
0.0076798145,
0.007955264,
-0.01614663,
0.009358749,
-0.03339506,
-0.0070961225,
-0.0052958583,
-0.01243461,
0.0043219454,
-0.018179715,
0.024541304,
-0.027099054,
-0.026744904,
0.020317733,
-0.0028987858,
-0.028148388,
0.013706928,
-0.0061123716,
-0.008775057,
0.0129461605,
0.0018166598,
-0.009699783,
0.023255868,
0.009693225,
0.024423253,
-0.014782495,
0.024567537,
0.0080995485,
-0.016290912,
0.014415229,
-0.02151135,
-0.011857476,
-0.029669924,
-0.0068600224,
-0.0011788614,
0.014992362,
-0.012447727,
-0.00078331155,
0.016920514,
-0.0020904704,
-0.011745985,
-0.019333983,
0.01993735,
0.00019552046,
-0.034575563,
-0.009306283,
-0.015294045,
0.0057155923,
0.03544126,
0.012218185,
0.019058531,
-0.019360216,
0.00018660523,
-0.023951052,
0.005151575,
0.015687546,
0.012782202,
0.011686959,
0.0005345046,
0.03355246,
-0.032660525,
-0.013995495,
0.012795319,
-0.012303444,
0.0025823459,
0.03454933,
0.020868633,
0.017156614,
0.023190286,
-0.002277383,
0.034916595,
-0.014953012,
-0.013588877,
0.01227721,
-0.025236487,
0.0060533467,
-0.014677562,
-0.0021150643,
0.018048547,
0.0212359,
-0.029853558,
-0.0056696837,
-0.0029463337,
0.018822432,
0.016986096,
0.0018658474,
0.0030414294,
-0.00789624,
0.023728069,
-0.024265854,
-0.00035189587,
-0.013549527,
0.0053680004,
0.006643597,
-0.004594116,
-0.014848079,
-0.63883466,
-0.014756262,
0.026102187,
-0.01993735,
0.016631946,
0.033998426,
0.015438329,
0.0068731387,
-0.0004689212,
0.044229437,
0.002431504,
0.01661883,
-0.014507045,
-0.031480026,
-0.005538517,
-0.012801877,
0.0098768575,
-0.018114131,
0.05451291,
0.0032791693,
-0.015149762,
0.013549527,
-0.011470534,
0.019556966,
-0.00068944535,
0.03777603,
0.029512525,
-0.001800264,
0.019517615,
0.03785473,
-0.0076601394,
0.011365601,
-0.0057319878,
0.030220825,
0.049082607,
-0.022980418,
-0.026666205,
0.023032885,
0.0050433623,
0.05209944,
-0.0028200855,
-0.012310002,
0.013615111,
0.015556379,
0.024055986,
-0.0036562737,
0.020107865,
-0.013274077,
-0.00023896946,
-0.025079086,
-0.0017543556,
0.008689798,
0.016448313,
-0.0012854344,
0.014782495,
-0.028043456,
0.006404218,
-0.012723177,
0.007948707,
-0.010965542,
0.0017625535,
-0.011031126,
-0.024816753,
-0.017458297,
-0.007128914,
0.044491768,
-0.02893539,
-0.011549234,
-0.025787387,
-0.006755089,
0.0077126063,
0.035677362,
0.011700076,
-0.0071748225,
-0.000081569335,
0.008735707,
0.01650078,
0.014730029,
-0.01736648,
0.002593823,
-0.0038071156,
0.029171491,
-0.0207637,
-0.0074109226,
0.020868633,
-0.02704659,
-0.025957905,
0.015398979,
0.0023232915,
-0.0069256057,
0.0047974247,
0.015569496,
0.0042530824,
-0.0424718,
-0.016290912,
0.036752928,
-0.020711234,
0.008591424,
0.02744009,
-0.017195964,
-0.012447727,
0.0032660526,
0.019871766,
0.0225738,
0.01614663,
0.01575313,
-0.011391834,
0.02033085,
0.039979633,
-0.033342592,
0.0035283861,
0.018835548,
-0.0039218864,
0.017773097,
0.0206063,
-0.021249017,
0.00003717246,
-0.006945281,
-0.016041696,
-0.025315188,
0.00040292792,
-0.011221318,
0.021012917,
-0.008237273,
-0.0050532,
0.018796198,
0.0032939257,
-0.006892814,
-0.0029610898,
-0.015215346,
0.0020593184,
-0.013129794,
0.016277796,
-0.008912782,
0.025800504,
0.016868047,
0.03651683,
-0.0039251656,
-0.0032086673,
-0.014874312,
-0.04989584,
-0.020776818,
0.00011743525,
0.00836844,
0.007824098,
-0.044622935,
-0.015136645,
-0.0018576494,
-0.0074896226,
-0.004358016,
-0.014021728,
-0.014834962,
-0.02608907,
0.004030099,
-0.022691851,
-0.0011518082,
-0.011378718,
-0.010211334,
0.010480225,
-0.0067747636,
-0.004030099,
0.013588877,
-0.015162879,
0.035073996,
-0.008506165,
-0.034286994,
-0.024528187,
0.021393301,
-0.028358256,
-0.038379397,
-0.0200554,
-0.0035218277,
-0.009371866,
0.00073084485,
-0.019189699,
0.0029774858,
0.003115211,
-0.0055483547,
0.011555793,
-0.004217012,
0.016081046,
-0.014782495,
-0.014310295,
-0.009903091,
0.03753993,
0.014349645,
0.04693147,
0.0094243325,
-0.0145857455,
0.021327717,
0.000029358813,
0.038982764,
-0.00967355,
-0.0017609139,
-0.01646143,
-0.0011870593,
0.0074305977,
0.0120739015,
-0.0043711327,
0.025000386,
0.018494515,
0.003738253,
-0.0071420306,
-0.009647316,
-0.0026430106,
-0.0077978647,
0.004554766,
-0.016999213,
0.0052761836,
-0.0104212,
-0.012388702,
-0.019596316,
-0.009306283,
-0.024541304,
-0.014218478,
0.0143758785,
-0.010755675,
0.012054226,
-0.038982764,
-0.010073608,
0.038458098,
-0.009778483,
0.036752928,
0.0034693612,
-0.017825564,
0.012146044,
-0.0012296885,
0.015661312,
-0.0070567722,
-0.018271532,
-0.002829923,
0.024265854,
0.009680108,
0.003193911,
-0.01093275,
0.012618244,
-0.0088144075,
-0.015517029,
0.0427079,
0.009706341,
0.018153481,
0.036097094,
0.0040497743,
-0.001780589,
0.02830579,
-0.009975233,
0.017956732,
-0.015202229,
-0.017104147,
0.00029164113,
0.0008870153,
-0.006469801,
-0.02877799,
-0.013785628,
0.010493342,
0.026416987,
0.004344899,
-0.030535625,
0.015621963,
0.029984724,
0.000008396467,
-0.0106441835,
0.00054065307,
0.0008902945,
-0.014716912,
-0.02704659,
0.014257828,
-0.006453405,
-0.015726896,
-0.022495102,
-0.05084024,
-0.002695477,
0.01196241,
-0.031558726,
0.020383317,
0.0032890069,
0.01716973,
-0.011418068,
0.012900252,
0.010690092,
-0.026416987,
-0.021209667,
0.022783669,
0.018953599,
0.012087018,
-0.0064796386,
-0.013483944,
0.0058008507,
-0.0076207896,
-0.02612842,
-0.012585452,
-0.0051942044,
-0.018625682,
-0.021799918,
-0.0209211,
-0.00029860935,
-0.004315387,
0.016435197,
0.022075368,
-0.037120197,
0.0097194575,
0.0054335836,
-0.03510023,
-0.0019642224,
0.013090444,
0.026967889,
-0.019819299,
-0.027151521,
-0.01255266,
-0.012034551,
0.01930775,
-0.0002941005,
0.0035316653,
-0.010080166,
-0.004338341,
0.015333395,
0.013483944,
0.0005217978,
0.02357067,
0.0022396727,
-0.04903014,
-0.036569297,
-0.0009116091,
0.00027053145,
0.06689505,
0.019478265,
0.0046203495,
0.02644322,
0.0022445915,
-0.007817539,
-0.014808728,
-0.022088485,
0.033342592,
0.017510764,
-0.008630774,
0.005577867,
0.0031955505,
-0.010270358,
0.0061287675,
0.0033103214,
0.008578307,
-0.002123262,
0.0022314747,
-0.015267813,
0.0024692144,
0.004902358,
0.0051942044,
0.046800304,
0.017589465,
-0.004013703,
0.016317146,
0.039376266,
-0.007371573,
-0.014572629,
-0.0035775737,
0.0016330263,
0.0002791393,
0.024318319,
-0.020134099,
0.0050532,
0.014664445,
0.013929911,
0.0103425,
0.0020904704,
0.020501366,
0.010047375,
0.007725723,
-0.020383317,
0.017300898,
-0.0037054613,
0.0078896815,
0.010729442,
0.0028823898,
-0.0070043057,
0.013903677,
-0.011077034,
-0.011234434,
-0.00074355165,
0.045882136,
-0.0014846439,
0.017746864,
0.009076741,
-0.0036890656,
-0.013628228,
0.003600528,
-0.0064238925,
0.009758808,
-0.017812448,
-0.0071354723,
-0.018494515,
-0.033578694,
-0.007371573,
-0.022455752,
-0.013995495,
0.0190323,
-0.022377051,
-0.030194592,
-0.028332023,
0.030456925,
0.020540716,
0.026075954,
-0.013411802,
-0.0023347687,
0.024174036,
0.0099293245,
-0.027099054,
-0.019819299,
-0.0047515165,
0.009070182,
0.004397366,
0.018651916,
-0.010394967,
0.0002490119,
0.0065747346,
-0.0015764607,
0.010080166,
-0.0037218572,
0.016356496,
-0.0065386635,
-0.012172276,
0.011995201,
0.025603754,
0.0206063,
-0.015451446,
0.0016608993,
-0.025236487,
-0.005036804,
-0.030247057,
0.009109532,
0.003875978,
0.00036009378,
0.025118437,
0.0077781896,
-0.0071420306,
0.029879792,
-0.031637426,
0.011686959,
-0.0015551461,
0.012782202,
0.010394967,
0.026967889,
0.013733161,
0.017878031,
-0.022888603,
-0.007961823,
-0.01930775,
0.019832416,
0.018665032,
-0.017864915,
0.0046695373,
0.005613938,
0.0052106,
-0.04903014,
0.023544436,
-0.0051646917,
0.023308335,
0.016605712,
-0.02494792,
-0.018442048,
-0.0027495835,
-0.0050171292,
-0.00868324,
0.002187206,
-0.011004892,
0.0014739867,
-0.010762233,
-0.007010864,
-0.022232767,
0.07020046,
-0.03323766,
0.004236687,
0.013483944,
-0.005089271,
0.024816753,
-0.029066557,
0.022088485,
-0.018966716,
0.02159005,
-0.00037915396,
-0.052519176,
0.0005976286,
-0.011523001,
0.028436957,
0.008794732,
0.038930297,
0.014047962,
0.018022314,
0.0005435223,
0.0087619405,
-0.013090444,
0.004013703,
0.025079086,
-0.021498235,
0.0155432625,
0.02467247,
0.020816166,
0.021432651,
0.0056860796,
0.007102681,
0.029381357,
-0.0118115675,
-0.024292087,
-0.017143497,
-0.018835548,
-0.0013124875,
0.013241285,
0.013654461,
0.005469654,
-0.049764674,
-0.00065911305,
0.030640557,
0.0020183288,
-0.008073315,
-0.011745985,
-0.015464563,
-0.017143497,
0.0013583959,
-0.010152308,
0.0008419267,
0.006978072,
-0.006663272,
-0.033263892,
-0.031794827,
-0.013824978,
-0.023636252,
0.03551996,
-0.0027135126,
0.0015690825,
-0.008493048,
0.018914249,
0.012972394,
-0.00548605,
-0.00785689,
-0.0042760368,
-0.018428931,
-0.0030135566,
0.011208201,
-0.017943615,
0.017038563,
0.012992069,
-0.0040333783,
0.02412157,
-0.016212214,
-0.014520162,
0.016671296,
0.0030856982,
0.0020478412,
-0.017379597,
0.020750584,
0.0021412976,
-0.012500193,
-0.0073453393,
-0.0021363788,
0.010913076,
0.008073315,
0.028148388,
0.0018756848,
-0.0023347687,
-0.019399567,
0.0009042309,
-0.012034551,
-0.04496397,
-0.04417697,
-0.0048498916,
0.010401525,
-0.0126838265,
-0.0009296445,
0.006279609,
-0.018219065,
0.0048138206,
-0.012428052,
0.013693811,
-0.023754302,
-0.0073125474,
-0.0028823898,
0.02704659,
-0.007469948,
-0.011103267,
0.011116384,
0.013628228,
-0.009102974,
0.00110508,
-0.020868633,
0.016369613,
-0.007784748,
0.015333395,
0.0063648676,
0.0070436555,
0.021786802,
-0.0131560275,
-0.0049548247,
-0.00493515,
-0.019963583,
0.03292286,
-0.013405244,
-0.017523881,
-0.00042998107,
-0.013549527,
0.0009206268,
-0.011404951,
0.014716912,
-0.012349351,
-0.007371573,
0.010611392,
0.0014764459,
0.031873524,
-0.026194004,
-0.003162759,
-0.01602858,
-0.010060491,
-0.0010288394,
-0.03565113,
-0.028961623,
-0.01775998,
-0.018009197,
0.008204482,
0.027807355,
-0.0020675163,
-0.0052171582,
-0.028751757,
-0.0030627442,
0.032949094,
-0.006502593,
0.047875874,
-0.001918314,
-0.00067673856,
-0.008381557,
0.00951615,
-0.014690679,
-0.01606793,
0.012972394,
-0.0202915,
-0.04753484,
0.027413856,
-0.000107700216,
0.033736095,
-0.013215052,
0.0062271426,
0.012644477,
0.012657594,
0.0023265707,
0.009680108,
-0.008322531,
0.0048892414,
0.0040366575,
-0.029433824,
0.026561271,
-0.030115891,
0.011831243,
-0.0041940575,
0.010873726,
0.0017461576,
-0.04777094,
0.015346512,
-0.02862059,
0.00098703,
-0.028332023,
-0.00019203636,
-0.013385569,
-0.013169144,
-0.014297178,
0.0097719245,
0.0061746757,
-0.0093193995,
-0.0035316653,
-0.018271532,
0.003990749,
0.016317146,
0.006607526,
-0.015464563,
0.0060926965,
-0.03058809,
-0.022481985,
-0.0028627147,
-0.025275838,
0.055090044,
0.0094243325,
-0.019556966,
-0.0075552063,
0.0022839415,
-0.05488018,
-0.003525107,
0.021524467,
-0.009142324,
0.022914834,
-0.011483651,
-0.012657594,
-0.0056073796,
0.013385569,
0.004646583,
0.012067343,
-0.013824978,
0.015425213,
0.008460257,
0.0019002786,
-0.004840054,
-0.014900546,
-0.0074109226,
0.024174036,
-0.018599449,
0.013057652,
0.011936177,
-0.015779363,
-0.008611099,
-0.022652501,
0.003639878,
0.01638273,
-0.0044268784,
0.010709767,
-0.010519575,
-0.011018009,
0.007988056,
-0.010467108,
-0.02494792,
0.004764633,
-0.0064402884,
-0.002529879,
0.01622533,
-0.022665618,
0.011063918,
0.022731202,
-0.014730029,
0.051259976,
0.006781322,
0.0087619405,
0.011267226,
0.013077327,
0.007627348,
-0.014179128,
-0.00002715562,
-0.024174036,
0.004666258,
0.0071420306,
-0.021012917,
0.010683534,
-0.0048466125,
-0.0009689945,
-0.016881164,
-0.0076207896,
-0.012690385,
0.006151722,
-0.025577521,
0.014782495,
0.00635503,
-0.023675602,
-0.0037448113,
-0.010768792,
-0.013956144,
-0.011523001,
-0.02775489,
-0.0025266,
-0.009286608,
-0.003990749,
-0.0052171582,
-0.0013272437,
0.01634338,
-0.0002586445,
-0.0020412828,
-0.015294045,
-0.0024183874,
0.17576347,
-0.020632533,
-0.011647609,
-0.011909943,
-0.010060491,
0.0020625975,
0.024069102,
-0.004125195,
-0.016369613,
-0.010847492,
0.0047187246,
-0.00001496121,
-0.041028965,
0.008748824,
0.0027692586,
-0.016959863,
-0.007751956,
-0.022232767,
-0.003446407,
0.00018271121,
0.026941655,
-0.015412096,
-0.013097002,
-0.0035415029,
0.031689893,
0.014480812,
-0.0212359,
0.009601408,
0.0061681173,
-0.00434162,
-0.019924233,
0.0022544288,
-0.00086897984,
0.009968675,
-0.0015608846,
0.0029381358,
0.010513017,
-0.015621963,
0.018796198,
-0.0097719245,
0.032581825,
-0.0039612367,
0.02775489,
-0.005807409,
0.014218478,
0.0386155,
0.013956144,
-0.007515856,
-0.021249017,
-0.0073518977,
-0.046013303,
0.017156614,
0.021708101,
0.03158496,
0.0005627874,
0.0033185193,
0.012460844,
0.01962255,
0.011942735,
0.023518203,
-0.036884096,
0.005830363,
-0.03363116,
0.011818126,
-0.009726016,
0.007378131,
0.029669924,
-0.0118115675,
-0.0080995485,
-0.029171491,
-0.01610728,
-0.02901409,
-0.010178542,
0.005443421,
-0.0044006454,
-0.020278383,
0.042734135,
0.008545515,
0.0075420896,
0.019137232,
-0.0018379744,
-0.010132633,
-0.024856104,
-0.034313228,
-0.014284061,
-0.038431864,
0.030693024,
0.0133986855,
-0.017969849,
-0.0069518387,
-0.003410336,
-0.027859822,
0.0019724204,
-0.014297178,
-0.0046564206,
-0.006230422,
0.01748453,
0.026823604,
-0.0090570655,
-0.00036050368,
-0.009089857,
0.06553092,
0.02877799,
0.005308975,
0.010211334,
-0.014913662,
-0.0011337728,
0.030561859,
-0.0020199683,
-0.028830457,
0.013588877,
-0.014126661,
0.008132339,
-0.009070182,
0.001851091,
0.0039022116,
0.011011451,
-0.0064960346,
0.0084996065,
0.010152308,
0.012191951,
-0.019963583,
0.008374998,
-0.0004279316,
0.016763113,
0.0026676042,
-0.032660525,
0.011470534,
0.0027872939,
0.005850038,
-0.012919927,
-0.02885669,
0.00083618815,
0.013280636,
-0.012572335,
-0.012860902,
0.0038825364,
0.003311961,
0.014362762,
0.011168851,
-0.011398393,
-0.028043456,
0.0065780138,
0.004803983,
0.005633613,
-0.009588291,
0.0032545757,
0.040005866,
-0.043075167,
-0.0106573,
-0.009555499,
-0.013811861,
0.011168851,
-0.02463312,
-0.0114115095,
-0.0039186073,
-0.010119516,
-0.0193471,
0.010067049,
-0.0028315627,
-0.019110998,
0.01870438,
-0.00030660233,
-0.008689798,
-0.010827817,
-0.0069190473,
-0.16369613,
-0.00085012463,
0.036752928,
-0.019360216,
0.01744518,
0.0059189005,
0.03315896,
0.0064402884,
-0.026666205,
0.00046687174,
0.039927166,
-0.013772511,
-0.038143296,
-0.01685493,
-0.008361882,
-0.0012050947,
-0.013588877,
0.0058402005,
-0.00021847466,
0.011772218,
0.02056695,
-0.010880284,
0.018153481,
0.018101014,
-0.0070436555,
0.040163267,
-0.01614663,
0.014205362,
0.0033545902,
-0.034916595,
-0.007725723,
0.0031398046,
0.035860997,
0.0002953302,
0.014362762,
0.03323766,
-0.0014125021,
-0.010585158,
-0.0045809997,
-0.0017215639,
-0.004882683,
0.039271332,
0.0045252535,
-0.015359629,
0.009102974,
0.024462603,
0.016277796,
-0.023046002,
0.013628228,
-0.025328305,
0.006991189,
0.0071748225,
-0.0047482373,
-0.005813967,
0.01302486,
0.000047727284,
0.0057647796,
0.014520162,
0.00085094443,
0.009693225,
-0.0022954184,
-0.013982378,
0.029932257,
0.009240699,
0.0069518387,
-0.019884882,
0.002116704,
0.013982378,
-0.042786602,
0.012054226,
-0.037723564,
0.005436863,
0.0010206414,
-0.028725524,
0.026246471,
0.023898587,
-0.0094767995,
-0.011791893,
-0.00035845418,
0.007023981,
-0.012250977,
0.008361882,
-0.025918555,
-0.014231595,
-0.01259201,
0.002195404,
0.0014379157,
0.014205362,
0.007574881,
0.009358749,
0.035467494,
-0.03887783,
0.0012813354,
0.0026266146,
0.0018642078,
0.025000386,
0.017248431,
-0.010565484,
0.014611978,
-0.005482771,
0.00074355165,
0.0024183874,
-0.010742559,
-0.002139658,
0.003875978,
-0.002060958,
-0.0065189884,
0.0043514576,
0.053699676,
0.002554473,
-0.006991189,
-0.003410336,
0.008637332,
0.026456337,
-0.0131560275,
0.042524267,
-0.004705608,
0.0045383703,
0.013903677,
-0.0016371253,
0.057188712,
-0.017235314,
-0.022954185,
0.0068600224,
-0.00016242136,
-0.027492555,
-0.13819732,
-0.04832184,
0.01772063,
0.0065189884,
-0.00080503605,
0.019019183,
-0.006437009,
0.012342793,
-0.0013444594,
0.023964169,
-0.030693024,
-0.024580654,
0.0036070861,
-0.0030414294,
0.0079421485,
-0.012808436,
0.013851211,
-0.019412681,
-0.03651683,
0.02439702,
0.011595143,
-0.011634492,
-0.008414349,
-0.00008059583,
0.012480519,
0.016081046,
-0.023977285,
0.0021068663,
0.010080166,
0.0028840294,
0.01654013,
-0.031086525,
0.036306962,
-0.031138992,
0.016946748,
-0.006194351,
-0.013549527,
-0.0143234115,
0.036805395,
-0.0037513697,
0.0029463337,
0.019963583,
0.035336327,
-0.006545222,
-0.008919341,
-0.033211425,
-0.021957317,
0.008998041,
0.0014526721,
0.0001570927,
-0.026587505,
-0.008060198,
-0.01677623,
-0.012880577,
0.02956499,
-0.02080305,
0.0069518387,
0.009148883,
0.004722004,
0.010834375,
-0.010985217,
0.007037097,
0.0077126063,
-0.0017740306,
0.018455165,
-0.015726896,
-0.012152601,
-0.041343767,
0.024567537,
-0.03035199,
-0.0033070422,
0.010755675,
-0.00017574299,
0.0015756409,
-0.033027794,
0.019648783,
-0.015464563,
-0.0023675603,
-0.014874312,
-0.0074305977,
-0.021170316,
-0.020986684,
0.033972193,
-0.019058531,
0.023990402,
0.016159747,
0.0022117996,
-0.005928738,
0.0045055784,
-0.013956144,
-0.014192245,
0.02995849,
0.0017887868,
-0.022022901,
0.0094243325,
-0.009050507,
0.003370986,
0.000978832,
0.0107491175,
0.032817926,
-0.020422667,
-0.006073022,
-0.023583787,
0.008532398,
-0.0022232768,
-0.0055516334,
-0.008578307,
-0.0016190899,
0.023150936,
-0.03557243,
-0.0029299378,
0.03129639,
-0.019779949,
-0.0009862102,
0.0044957413,
-0.009378424,
-0.032817926,
-0.034575563,
0.034942828,
0.0038464656,
0.012454285,
0.003797278,
0.009647316,
0.008558632,
0.024423253,
0.0121263685,
-0.03559866,
-0.0075879977,
-0.00951615,
0.00532865,
0.011601701,
-0.005325371,
0.016369613,
-0.03659553,
0.0057778964,
0.004200616,
-0.026272705,
0.0009427612,
0.016448313,
0.015661312,
0.019006066,
0.06804932,
-0.00064845575,
-0.012264093,
-0.009398099,
-0.033578694,
-0.0019232328,
0.002902065,
-0.02502662,
0.003407057,
-0.012244418,
-0.015923645,
0.024095336,
0.016015463,
-0.007378131,
-0.015648196,
-0.00315784,
-0.010080166,
0.004725283,
0.010375292,
-0.014402112,
-0.0009558778,
0.017904265,
-0.0014002053,
0.011667284,
-0.014336528,
-0.0012772365,
-0.0034726404,
-0.018022314,
0.017982965,
0.0128936935,
0.017471414,
-0.026941655,
0.0052565085,
0.013759394,
0.0047941455,
0.00044514725,
-0.014297178,
0.015884297,
0.023544436,
-0.021419534,
0.03761863,
0.02549882,
-0.0005689359,
-0.017812448,
0.008355323,
0.039796,
0.010408083,
-0.012218185,
0.01716973,
-0.0071354723,
-0.002624975,
-0.0009214466,
0.010231008,
0.013903677,
0.006656714,
0.005108946,
0.017418947,
0.003931724,
-0.0004681014,
0.016172864,
0.015858063,
0.013287194,
-0.008217598,
0.006059905,
-0.034444395,
0.019452032,
0.011404951,
-0.026325172,
-0.041632332,
-0.007305989,
-0.0009853904,
0.020396434,
0.0098768575,
-0.008991483,
-0.013798744,
-0.03150626,
0.015346512,
-0.011496767,
-0.011378718,
-0.013706928,
0.004515416,
0.021576934,
0.038589265,
0.0057418253,
-0.018101014,
0.0074633895,
0.0142709445,
0.019950466,
-0.011536118,
0.0027938522,
0.0050991084,
0.015818713,
-0.0032906465,
-0.022180302,
-0.012939602,
-0.008630774,
-0.04150117,
0.00872259,
-0.0011862395,
-0.008788174,
0.05818558,
0.0020330849,
-0.013372452,
-0.0073518977,
-0.0209211,
-0.0010452352,
-0.0050630374,
0.017668163,
0.0052958583,
-0.01302486,
0.0045449287,
0.0054139085,
0.011057359,
-0.0031611193,
-0.0036300404,
0.0066665513,
-0.01610728,
0.032503128,
0.007974939,
-0.012428052,
0.011752543,
-0.025354536,
0.0193471,
0.015569496,
-0.0020642371,
-0.011018009,
0.025000386,
-0.010899959,
-0.0055057253,
-0.02612842,
0.011549234,
-0.0023478852,
-0.057975713,
0.0013928271,
0.0045383703,
-0.017432064,
-0.028909156,
-0.019675016,
-0.02838449,
0.022927951,
-0.0078372145,
0.008532398,
-0.015018595,
-0.007850331,
-0.029984724,
0.008657007,
0.0069256057,
-0.031453792,
-0.016212214
] |
Urease, a nickel-dependent metalloenzyme, is synthesized by plants, some bacteria, and fungi. It catalyzes the hydrolysis of urea into ammonia and carbon dioxide. Although the amino acid sequences of plant and bacterial ureases are closely related, some biological activities differ significantly. Plant ureases but not bacterial ureases possess insecticidal properties independent of its ureolytic activity. To date, the structural information is available only for bacterial ureases although the jack bean urease (Canavalia ensiformis; JBU), the best-studied plant urease, was the first enzyme to be crystallized | [
-0.01368918,
-0.021725284,
0.010491949,
-0.0058483514,
-0.007301337,
0.022532867,
-0.007374152,
-0.017952155,
-0.03953181,
-0.021526698,
0.008671579,
0.0060370076,
0.007897095,
0.0016085448,
-0.010584622,
0.0048289443,
0.022268085,
0.023406643,
0.012722729,
-0.013311867,
-0.02373762,
-0.0003164961,
-0.0048620417,
-0.027484272,
-0.0015200087,
0.013675941,
0.018243413,
-0.03169429,
0.0022407095,
-0.013728897,
-0.010769969,
-0.00949902,
-0.01775357,
0.00279344,
0.0011691737,
-0.00055107556,
0.017660895,
0.011001652,
0.016244316,
0.008089061,
0.010869262,
0.0040445304,
-0.01578095,
0.00072028715,
-0.017634418,
-0.0028447413,
-0.0019080783,
-0.00950564,
-0.032012027,
0.01075011,
0.026001498,
0.0105912415,
0.004223258,
0.011326009,
-0.02053377,
-0.010485329,
0.010498568,
0.018600868,
0.009015795,
-0.011802615,
-0.016310511,
0.008333983,
-0.021553177,
0.03087347,
0.00851933,
0.01633699,
-0.0005146681,
-0.009644649,
0.014152546,
-0.021539938,
0.026557539,
0.0072880983,
-0.005633217,
-0.0036539782,
0.036672175,
-0.019461406,
-0.033786062,
-0.017157812,
0.0049944324,
0.0096181715,
0.0084001785,
-0.0139672,
-0.022532867,
-0.002848051,
0.012683012,
0.0013884456,
0.014470284,
0.015741233,
0.0044450117,
-0.009856475,
0.011352487,
0.04247088,
0.026795842,
0.007956671,
-0.018349325,
0.012961032,
-0.010650817,
0.033309456,
-0.011994581,
-0.03852564,
-0.009995484,
0.009690986,
-0.00851933,
-0.015701516,
-0.01746231,
0.03826086,
-0.0073410543,
-0.051897082,
0.01494689,
-0.017104855,
-0.020282228,
0.04067037,
0.016231077,
-0.049302228,
0.024915896,
-0.01901128,
0.05782818,
-0.01382157,
0.008492852,
-0.00936001,
0.009465923,
0.01158417,
0.015291105,
-0.035666008,
0.026266279,
0.0032286737,
-0.000426132,
-0.013609746,
-0.007824279,
-0.008810589,
0.017515266,
0.011504736,
0.012782305,
0.023088906,
-0.018349325,
0.037890166,
-0.026914993,
-0.017356398,
-0.0020884604,
-0.044033088,
0.005292311,
0.020096881,
-0.036354437,
0.006943883,
-0.00004721584,
0.021434026,
0.019077474,
0.004355648,
-0.004034601,
0.0062091155,
0.016191361,
-0.0064672767,
-0.0052592135,
-0.016800357,
0.025723478,
0.007374152,
-0.0039783353,
0.022043021,
-0.030211516,
-0.0069041657,
0.012729349,
-0.025471937,
0.011465019,
-0.030767556,
0.015714755,
0.02148698,
0.017965393,
0.001130284,
0.0076852697,
-0.01803159,
-0.0018964942,
0.0034322243,
-0.027907921,
0.024730548,
-0.004398675,
-0.0045045875,
0.021950347,
0.01507928,
-0.010101397,
-0.019395212,
0.017329918,
0.009975625,
0.020427857,
0.015688276,
-0.012186548,
-0.010995032,
0.015529408,
-0.0034189853,
0.02514096,
-0.021301635,
-0.012954412,
0.016720923,
0.008175114,
-0.018931845,
-0.63505083,
-0.026981188,
0.0066923406,
-0.013139759,
0.009942528,
0.025220394,
-0.0045641633,
-0.0032154347,
0.0069836,
-0.0027950949,
-0.0043357895,
-0.0015191812,
-0.0006855347,
-0.020043924,
0.00014211294,
-0.019223103,
-0.010187451,
-0.034686316,
0.013636224,
-0.008281027,
-0.03296524,
0.0030631856,
-0.029152393,
-0.038763944,
0.008618623,
0.025035048,
0.038313817,
-0.028569873,
0.00034380163,
0.001556416,
-0.013292008,
0.044350825,
-0.023817055,
0.0032832848,
0.04758115,
0.011577551,
-0.0071954248,
0.012524143,
0.003140965,
0.03029095,
0.004693244,
-0.038896333,
0.015185192,
-0.013503833,
-0.010399275,
0.012272601,
0.026319236,
0.010319841,
0.0074800644,
-0.009969006,
0.004411914,
-0.00019568973,
0.01144516,
0.009313673,
0.0016209565,
0.038075514,
0.016085448,
-0.033600714,
-0.00991605,
0.010915598,
-0.017065138,
0.028463962,
-0.014695347,
-0.016906269,
-0.022056261,
-0.0025601017,
-0.02234752,
-0.0065268525,
0.0023333828,
0.015264627,
0.014059873,
0.020096881,
0.0040809377,
-0.0064705866,
0.013047086,
0.031244162,
0.001145178,
-0.00963803,
-0.011491497,
0.011782756,
0.02165909,
0.002988716,
-0.016138405,
-0.0078110406,
0.042921007,
-0.027484272,
-0.0212222,
-0.0060833446,
0.005206257,
-0.012219645,
0.013146379,
0.0090819895,
-0.043397613,
-0.02933774,
-0.053141553,
0.025577849,
-0.036486827,
-0.009849855,
0.013106662,
-0.012133591,
-0.015476452,
-0.01649586,
0.019646753,
-0.0048521124,
-0.005375055,
0.0023664807,
-0.02597502,
0.022268085,
0.03127064,
0.004057769,
0.009525497,
0.0051930184,
-0.023684664,
-0.0102536455,
0.0066294554,
-0.022559345,
0.009088609,
-0.001374379,
-0.004203399,
-0.021539938,
-0.007513162,
0.0030681503,
-0.007552879,
-0.00726162,
0.014589435,
0.017846242,
0.0072880983,
-0.03685752,
-0.000006244592,
-0.003548066,
0.01229246,
-0.005010981,
0.019064235,
-0.00824131,
0.023750858,
0.03137655,
0.03479223,
0.0018170599,
0.019395212,
-0.010942076,
-0.010584622,
-0.01452324,
-0.015555886,
0.012749207,
-0.028199181,
-0.006377913,
-0.018097784,
0.02568376,
-0.005275762,
0.01870678,
0.016628249,
0.007850758,
-0.0049216175,
0.027854966,
0.0038591838,
0.009194521,
-0.0156088425,
-0.010445612,
-0.014417328,
0.00028401904,
0.012610197,
0.0032783202,
-0.016085448,
0.010664056,
-0.02416127,
-0.0015837216,
0.016840074,
0.007069654,
0.019752666,
-0.032541588,
-0.0034984194,
-0.0010136149,
-0.0021745143,
0.012537383,
0.01298089,
-0.0017823074,
-0.027590184,
0.007824279,
0.025326306,
0.0072814785,
0.010180831,
-0.0031078674,
-0.0040114326,
-0.0107368715,
0.007036556,
0.018375805,
0.027034145,
0.008406798,
0.007440347,
0.02933774,
0.005739129,
0.0040676985,
0.012921315,
0.0053254087,
0.00027512404,
-0.026200084,
0.0016813596,
0.009320293,
-0.00081668404,
0.023049189,
0.020745594,
-0.017991873,
-0.0074933036,
-0.035533614,
-0.021063332,
-0.0063084085,
0.0055471626,
-0.0029820965,
0.03685752,
0.017700613,
0.007208664,
-0.030449819,
-0.016641488,
-0.02597502,
0.006685721,
-0.0060270783,
0.0034984194,
-0.03031743,
-0.0013950651,
-0.015953058,
-0.004676695,
-0.0116636045,
0.023300732,
-0.004901759,
-0.042338487,
0.03921407,
-0.018481717,
0.006311718,
-0.015489691,
-0.0058020144,
0.01131939,
0.014788021,
0.0008605384,
-0.004719722,
0.012689631,
0.022016544,
0.02487618,
-0.007936812,
0.018640585,
-0.003700315,
-0.023340449,
-0.00726162,
-0.0025650663,
0.0040147426,
0.03714878,
0.008777492,
0.031350076,
0.005143372,
-0.02150022,
0.026186844,
-0.004021362,
0.02891409,
-0.015926579,
-0.010578003,
0.0021414168,
-0.013901005,
0.021328112,
0.018203696,
0.05846365,
0.0023499317,
0.007989768,
0.008135397,
0.011286292,
-0.00019537944,
-0.0030003001,
0.008704676,
0.020547008,
-0.022334281,
-0.022307802,
0.0019196626,
-0.035692483,
-0.007599216,
0.0064010816,
-0.0038393252,
0.013292008,
0.0189848,
-0.0136627015,
0.005375055,
0.0006917405,
-0.0103397,
-0.0064043915,
-0.022982994,
0.022162173,
0.018375805,
0.008585525,
-0.017674135,
-0.009154804,
0.008631862,
0.0036705271,
0.022930037,
0.008539189,
0.024545202,
-0.003965096,
0.04514517,
-0.004521136,
-0.0018700161,
0.014814499,
-0.019646753,
0.011107565,
-0.00058913784,
-0.015238149,
-0.011465019,
-0.00991605,
-0.008711296,
0.051049784,
0.018892128,
-0.0060800347,
0.000010129685,
0.022704974,
-0.014046635,
-0.007969909,
0.028463962,
-0.010167592,
0.004981193,
-0.024306899,
0.0030698052,
-0.0056067384,
0.010955315,
0.034395058,
0.014589435,
-0.005768917,
-0.022996234,
0.0008878439,
0.007890475,
0.025604326,
0.009988865,
0.0023102146,
0.017885959,
0.028252138,
-0.020825028,
-0.022268085,
-0.0349511,
0.0007306302,
-0.007989768,
-0.020705877,
-0.015913341,
0.02667669,
0.01550293,
-0.014562957,
-0.005573641,
-0.010796447,
-0.00042944174,
-0.011928386,
0.0046965536,
0.028781699,
-0.00078606873,
0.025498414,
0.026266279,
0.01774033,
0.015423495,
0.025697,
0.020864746,
0.030688122,
-0.00016269553,
0.012755826,
-0.012808783,
-0.0016002704,
-0.004441702,
-0.0012668117,
-0.014986607,
0.002359861,
0.01954084,
0.01075673,
-0.00851933,
0.017872721,
0.028437484,
0.0035910928,
-0.014761543,
-0.001543177,
-0.042153142,
0.016562054,
0.024690831,
-0.007870616,
-0.017793287,
0.024333378,
-0.014165785,
-0.00020437787,
-0.03423619,
0.025021808,
-0.010730252,
0.021169243,
0.009485781,
-0.007857378,
-0.01604573,
0.0056530754,
-0.0013718967,
0.027325403,
-0.001898149,
-0.010485329,
0.0140995905,
-0.011822473,
-0.011292911,
-0.023366926,
-0.0045343754,
0.016257556,
-0.040193763,
-0.020149836,
0.0025038356,
0.015648559,
0.007691889,
-0.0060965833,
-0.023750858,
0.004388746,
0.02487618,
-0.017250484,
-0.0060105296,
-0.006718819,
-0.035533614,
-0.0045343754,
0.0010698809,
0.0114584,
-0.004319241,
-0.0143908495,
-0.010160972,
0.010988413,
-0.014364371,
0.03293876,
0.023380166,
-0.010306602,
0.0042398064,
0.033839017,
0.034871664,
0.003922069,
-0.022612302,
-0.011630507,
-0.016403185,
-0.0056067384,
-0.026782602,
-0.00040648028,
-0.026226562,
-0.005153301,
0.023975924,
-0.006576499,
0.0047627487,
0.01256386,
0.00032290875,
0.0050473884,
0.004845493,
0.00936663,
0.031667814,
-0.029231826,
0.005143372,
0.0075462596,
-0.000031261745,
0.016840074,
-0.00026209187,
0.02891409,
0.003534827,
-0.023221297,
0.0212222,
-0.00037814042,
-0.018256653,
-0.010511807,
0.014682109,
-0.009134945,
0.031244162,
0.017409353,
-0.042206097,
-0.032700457,
-0.030952904,
-0.012385133,
-0.007301337,
0.007738226,
-0.031191206,
-0.020904463,
0.0064573474,
-0.01927606,
0.021341352,
-0.008572286,
-0.030105604,
-0.00032249503,
0.010677296,
-0.007890475,
0.0035613049,
-0.02120896,
-0.005977432,
-0.0065003745,
-0.0032700459,
-0.017621178,
-0.010902359,
0.013675941,
0.019103952,
0.028437484,
0.021076571,
0.0206794,
-0.014576197,
0.008413417,
0.014073112,
-0.0039750254,
-0.0077448455,
-0.012206406,
0.010438993,
-0.020692639,
0.027272448,
0.03601022,
0.00096396846,
-0.0008828793,
-0.006785014,
-0.029708432,
0.023671424,
-0.005917856,
-0.020136598,
-0.024730548,
-0.036486827,
-0.020216033,
0.0019097333,
-0.029814346,
-0.01131939,
-0.012226265,
-0.033468325,
0.032064985,
-0.013060325,
0.010723632,
-0.009644649,
0.020454336,
0.013351584,
0.035692483,
0.0057490584,
0.0132721495,
-0.012947793,
-0.02289032,
-0.011935005,
-0.005239355,
-0.0061131325,
-0.005735819,
-0.0033147277,
0.00516654,
-0.028543396,
-0.0043953652,
0.006804873,
0.005236045,
0.008479613,
0.0015671728,
-0.019050995,
-0.011431921,
0.0036142613,
0.008817209,
-0.056451317,
0.005222806,
0.0031906115,
0.00090604764,
0.014324654,
-0.018442,
-0.013781853,
0.028569873,
0.005633217,
0.04578064,
0.0022258156,
0.008439896,
0.03137655,
0.004021362,
-0.017713852,
-0.004858732,
0.0005643146,
0.00921438,
0.03225033,
0.013570028,
-0.0170519,
-0.021447264,
-0.0066559333,
-0.009452683,
-0.0045740926,
-0.01340454,
0.025776435,
0.0031111771,
0.0004848803,
-0.020851508,
-0.0059046173,
0.0076455525,
0.026716407,
-0.032859325,
-0.0072880983,
-0.032541588,
0.017104855,
-0.014231981,
-0.0008117194,
0.009009175,
0.03015856,
0.00090687507,
-0.0058814487,
-0.008605383,
-0.020613205,
-0.010240407,
0.009922669,
0.015449974,
0.008784111,
-0.0022522938,
0.019024517,
-0.014046635,
-0.0012213025,
0.0020024066,
-0.018071307,
-0.0019726187,
0.035930786,
-0.01703866,
-0.0071292296,
0.01927606,
0.030237995,
-0.000012256466,
0.001291635,
-0.004812395,
-0.024823222,
0.0010425753,
-0.009280575,
0.032038506,
0.03937294,
-0.007863997,
-0.00962479,
-0.012954412,
0.020136598,
-0.010074918,
-0.0076455525,
0.009307054,
-0.029999692,
0.010677296,
0.012749207,
0.0061230618,
0.02179148,
-0.01677388,
-0.013100042,
-0.031800203,
0.014920412,
-0.011987962,
0.008784111,
-0.0034520829,
-0.0002577478,
-0.01270287,
-0.013212574,
-0.012669773,
-0.021553177,
0.023353688,
-0.039002247,
-0.022731451,
0.027484272,
-0.02165909,
-0.0028894232,
0.006381223,
-0.020864746,
-0.009419586,
-0.010723632,
0.03113825,
-0.012285841,
0.0105449045,
0.040564455,
-0.013861287,
0.006030388,
0.011140662,
-0.014562957,
-0.024902657,
0.015741233,
-0.013497214,
-0.015317583,
-0.0070166974,
-0.042073708,
-0.03643387,
0.006483826,
0.014086352,
-0.016297273,
0.012504284,
0.0028017145,
-0.021182483,
0.016919509,
-0.0019196626,
-0.016257556,
-0.013000749,
-0.0041140355,
0.0064441087,
-0.0078044212,
-0.0013536931,
-0.01229246,
0.012557241,
-0.032382723,
-0.0315619,
0.003505039,
-0.001654054,
0.057192706,
-0.0132721495,
-0.023949444,
-0.018640585,
0.017131334,
-0.03924055,
-0.004421843,
-0.008208212,
-0.0022853913,
0.014086352,
-0.01229246,
0.0066261454,
-0.00040296363,
-0.033786062,
0.026451625,
-0.031323597,
-0.0045906412,
0.014973368,
-0.0016466071,
0.03473927,
-0.002947344,
-0.020983897,
-0.017329918,
-0.0010293362,
-0.020652922,
-0.012272601,
0.024915896,
-0.015449974,
-0.01019407,
-0.0012560551,
-0.005487587,
0.026795842,
0.024505485,
0.05237369,
-0.029681955,
-0.032726936,
0.0042729042,
-0.008333983,
-0.018680302,
-0.0059542637,
0.014602674,
0.012822022,
0.021619372,
0.0068379706,
-0.015542647,
0.0018534673,
-0.02289032,
0.019633515,
0.005183089,
-0.01494689,
0.01298089,
-0.0008688128,
-0.02989378,
-0.028569873,
-0.00007736571,
-0.004974574,
0.008254549,
0.007466825,
-0.001096359,
0.007149088,
-0.022109216,
0.016350228,
-0.016217839,
0.0049944324,
0.0019511053,
-0.0016664657,
-0.011431921,
0.010723632,
0.017157812,
0.0010599516,
-0.006910785,
0.021698806,
-0.020467574,
-0.005461109,
-0.020467574,
0.025021808,
0.00991605,
-0.013331725,
-0.00018265755,
-0.019607035,
0.008486233,
0.0021215582,
-0.012047538,
-0.020149836,
0.016800357,
0.17009534,
-0.019368732,
0.025670521,
0.002570031,
-0.007096132,
-0.023274254,
-0.008360461,
-0.013901005,
-0.008433276,
0.004219948,
0.012941173,
0.002962238,
-0.03563953,
0.00029105227,
0.0063084085,
-0.014006917,
-0.018349325,
0.004716412,
-0.013622984,
0.019117191,
-0.010068299,
-0.017674135,
0.006649314,
0.0060436274,
0.045356993,
0.00077282963,
-0.0062488327,
0.011921766,
0.022532867,
0.0027950949,
0.0007984803,
0.0020553628,
-0.01368918,
0.0073410543,
0.03802256,
-0.008956219,
0.000232304,
0.0094725415,
0.016734162,
0.004716412,
0.021725284,
0.0058715194,
-0.00053038955,
-0.00060030824,
-0.0014198883,
0.0011402133,
-0.01466887,
-0.014695347,
-0.01270287,
0.023366926,
-0.026358953,
0.00851933,
-0.012299079,
0.022029782,
0.013861287,
0.0019362114,
0.008022865,
0.014006917,
0.002149691,
0.0051731598,
-0.014073112,
0.024200987,
-0.019103952,
0.009465923,
-0.034024365,
0.008267788,
-0.013152998,
0.004319241,
0.03810199,
0.0010624339,
-0.030608688,
-0.015675038,
0.0069505023,
0.016985703,
0.00021347971,
-0.0048388736,
0.0051499913,
0.037095822,
0.026239801,
0.009121707,
0.0009159769,
0.00907537,
-0.032038506,
0.0043788166,
-0.0124447085,
-0.022678496,
-0.0059741223,
0.0059972904,
-0.011180379,
-0.020414619,
0.010922218,
-0.042497355,
0.0017988562,
-0.019448167,
0.002748758,
0.017938916,
0.009671127,
0.0013470736,
0.011557693,
-0.010908979,
0.00012928761,
0.04006137,
0.011478258,
0.004064389,
-0.021539938,
0.016972465,
-0.013080183,
0.0086451005,
0.002750413,
-0.0055504725,
0.019752666,
-0.022850603,
-0.0044681802,
-0.027325403,
-0.0012866703,
0.020123359,
0.011180379,
-0.0167474,
0.025273351,
-0.030899948,
0.017409353,
-0.012557241,
-0.006414321,
0.022082739,
-0.0142452195,
-0.014192264,
-0.033044674,
0.036672175,
-0.014867456,
-0.013649463,
0.0076587917,
0.009346771,
-0.006553331,
0.018362565,
0.009439444,
0.021553177,
-0.004345719,
-0.010783208,
-0.019620275,
0.012338797,
0.0003450428,
0.0002852602,
0.024836462,
0.009518879,
0.016442902,
-0.016787117,
0.03029095,
0.019355495,
-0.02024251,
-0.023684664,
0.016667966,
-0.012656534,
-0.011855571,
0.0036142613,
-0.008612003,
-0.014165785,
-0.040193763,
-0.027166534,
0.018190457,
-0.0001330111,
-0.036804564,
-0.009201141,
0.017343158,
-0.0057589877,
0.0008216487,
0.014205502,
-0.16596475,
0.004358958,
0.025789673,
-0.008307505,
0.026279518,
0.014457045,
-0.013232432,
0.00030429134,
0.024465768,
0.01550293,
0.035083488,
-0.012265982,
-0.053432815,
-0.044086043,
0.0020189555,
0.029946735,
-0.00050598005,
0.020361662,
0.026027976,
0.0021563105,
0.004577402,
-0.010366178,
-0.011471638,
-0.018746497,
0.042815093,
0.032064985,
0.020057164,
-0.0021281776,
-0.008075822,
-0.020626443,
-0.013325105,
0.018971562,
0.008433276,
-0.018667063,
0.019183386,
0.010809686,
0.010856023,
-0.0019246272,
-0.002149691,
0.011981342,
-0.00089611835,
0.015820667,
0.0042497357,
-0.0068644485,
0.0046270485,
0.025458697,
-0.008075822,
0.007360913,
0.018402282,
0.0033279667,
0.013715657,
-0.0035447562,
0.013225812,
0.037545953,
0.026875276,
-0.0013619675,
-0.008228071,
0.037890166,
-0.014311415,
-0.0034123657,
-0.0012899801,
-0.024823222,
0.008916502,
0.013431018,
-0.0041736113,
-0.021036854,
-0.008347223,
0.015198432,
-0.043371134,
-0.013781853,
-0.00949902,
-0.023115385,
0.017859481,
-0.00963803,
0.011478258,
-0.01607221,
-0.006063486,
-0.006778395,
-0.010048441,
-0.017965393,
-0.018680302,
0.024412813,
-0.025789673,
0.0013073564,
-0.012775685,
-0.002081841,
-0.0050308397,
0.01074349,
-0.024902657,
0.01243147,
0.022413716,
-0.03158838,
-0.019659992,
-0.028543396,
0.017541744,
0.01924958,
0.0063381963,
0.0033577546,
-0.0009788624,
-0.005332028,
0.028781699,
-0.003935308,
-0.03280637,
0.015132236,
0.042921007,
0.01159079,
-0.018640585,
-0.010187451,
0.03812847,
0.0031492396,
-0.012352035,
0.0124910455,
0.0063878424,
0.05777522,
-0.0324092,
0.025802912,
0.0051599205,
-0.019871818,
-0.0030069198,
-0.035401225,
0.021526698,
0.025471937,
0.0029407244,
-0.0057589877,
0.008982697,
-0.03354776,
-0.124235265,
-0.0088370675,
-0.02641191,
0.034871664,
-0.016125165,
-0.0046435976,
-0.0064639673,
0.04620429,
0.010386037,
0.028146224,
-0.018614108,
0.011352487,
0.003922069,
-0.012722729,
0.01772709,
0.03002617,
0.00083406025,
-0.00080509984,
-0.026001498,
0.02458492,
-0.013146379,
-0.0003065668,
0.0019246272,
0.00852595,
0.0027437934,
0.014761543,
-0.010988413,
0.021434026,
0.0018203696,
-0.0028646,
0.02694147,
-0.021328112,
-0.003587783,
-0.013239052,
-0.025352785,
0.004160372,
-0.0092276195,
-0.0035844734,
0.03015856,
-0.0132721495,
-0.012947793,
-0.025008569,
0.02123544,
-0.007076273,
0.032462154,
-0.014351132,
-0.002108319,
-0.008890023,
-0.015900102,
-0.020507291,
-0.03799608,
-0.033177063,
-0.045436427,
-0.01661501,
0.0341038,
0.0005175642,
-0.011299531,
0.041967794,
-0.04313283,
-0.035215877,
-0.016284034,
-0.023221297,
-0.025869107,
-0.001984203,
0.0072814785,
-0.0031360004,
-0.00781766,
-0.02543222,
0.0017094926,
-0.030608688,
-0.019315777,
0.009062131,
-0.015410257,
0.0029291403,
-0.009651269,
0.0033445156,
-0.014761543,
0.0003963441,
0.0019742737,
-0.03672513,
0.0058119437,
-0.026862036,
-0.000056834837,
-0.034500968,
-0.008300886,
0.0045608534,
0.017329918,
0.018812694,
0.017634418,
-0.021844435,
-0.014496762,
0.023658186,
0.028225658,
-0.008367081,
-0.004428463,
0.009790279,
-0.021606132,
-0.007652172,
0.024267182,
0.010961935,
-0.028728742,
-0.02372438,
-0.05097035,
0.0035712342,
-0.002611403,
-0.011935005,
0.015185192,
0.010769969,
0.006546711,
0.02290356,
0.026213324,
0.035136443,
-0.036619216,
0.012504284,
0.009955768,
-0.029523086,
-0.021407546,
-0.015992776,
0.041146975,
-0.013980439,
0.013040466,
-0.0037632005,
-0.015304344,
0.019037757,
0.009796899,
0.028596353,
-0.04006137,
0.0044086045,
-0.034686316,
0.0026974569,
-0.0040180525,
-0.029231826,
0.0045277555,
-0.035930786,
0.0014198883,
-0.016985703,
-0.008022865,
-0.023922967,
-0.018614108,
0.010286744,
0.013497214,
0.014179025,
-0.009995484,
-0.048507888,
-0.012040918,
0.0029291403,
-0.007910334,
-0.004547614,
-0.008095681,
0.006017149,
0.0055140653,
-0.002288701,
0.055815842,
0.0075065424,
-0.008161875,
-0.02610741,
-0.0032717008,
-0.011306151,
0.0016995633,
-0.012782305,
-0.004262975,
0.00065905653,
0.023115385,
0.034395058,
0.022771169,
0.0083737,
-0.0248497,
0.01480126,
-0.013861287,
-0.012352035,
0.019818861,
-0.021751763,
-0.001237024,
-0.004653527,
-0.0019643444,
0.0008812244,
-0.0022804267,
0.0030052648,
-0.019183386,
0.020004207,
-0.015833907,
0.006718819,
0.025802912,
-0.011908527,
-0.0069769803,
0.011656986,
0.009465923,
-0.0071821855,
0.015873624,
0.007824279,
0.01646938,
-0.002331728,
0.019620275,
0.025882347,
-0.007691889,
0.004094177,
-0.01927606,
0.0028728743,
-0.0142452195,
-0.04228553,
-0.004663456,
0.032223854,
-0.0010227168,
0.013305247,
0.0032468776,
-0.031508945,
0.0044383924,
0.017581461,
-0.03982307,
-0.019236343,
-0.014893933,
0.019779144,
-0.0067221285,
0.008777492,
-0.019196626,
0.0030698052,
0.0026792532,
0.013728897,
-0.016006013,
-0.0109354565,
0.0023366928,
0.01829637,
0.0034719415,
0.0038989007,
0.024598159,
0.0025435528,
0.021301635,
0.0020702567,
0.015476452,
-0.003730103,
0.01047871,
-0.022956517,
0.0036572882,
0.004772678,
-0.036619216,
-0.019911535,
0.009876333,
0.009187902,
0.024982091,
0.02933774,
0.0069637415,
0.07853406,
-0.00077448454,
-0.0062389034,
0.00879735,
-0.0055372333,
0.006493755,
-0.005408153,
0.010630959,
0.009849855,
-0.0035844734,
-0.009995484,
0.0050606276,
0.023803815,
-0.023565512,
0.0015042872,
0.011041369,
-0.001381826,
0.010571383,
-0.012663153,
-0.024108313,
0.026504582,
-0.0014165785,
0.001760794,
0.017515266,
-0.037095822,
0.013053705,
0.029681955,
-0.028146224,
-0.008367081,
-0.03293876,
-0.0043026917,
0.0076786503,
0.002109974,
0.010558144,
0.018468477,
-0.019938013,
-0.01744907,
-0.013239052,
0.013536931,
0.036354437,
-0.013523691,
-0.006715509,
-0.013755375,
-0.015118998,
-0.0058152536,
-0.011047989,
-0.009565215,
0.007102751,
-0.005113584
] |
Using differential interference contrast optics, combined with cinematography, we have studied the morphological changes that the living, syncytial embryo undergoes from stage 10 through 14 of Drosophila embryogenesis, that is just prior to and during formation of the cellular blastoderm. We have supplemented these studies with data collected from fixed, stained, whole embryos. The following information has been obtained. The average duration of nuclear cycles 10, 11, 12 and 13 is about 9, 10, 12 and 21 min, respectively (25 degrees C). In these four cycles, the duration of that | [
-0.029382532,
-0.012309622,
0.0011264308,
-0.02202352,
-0.015012387,
-0.0069308523,
-0.01696587,
0.007231903,
-0.036928866,
-0.009319187,
0.0027010923,
0.018384153,
0.018732034,
-0.0013597449,
0.013246224,
0.02696075,
0.011553651,
0.007867455,
-0.017822191,
-0.00067485496,
-0.025100926,
0.0063822716,
-0.010101918,
0.0010511682,
0.00022097946,
0.007245283,
-0.006081221,
-0.01081106,
0.004375268,
-0.010021638,
0.0024084044,
-0.0056263,
-0.00055318035,
-0.025074165,
-0.009887838,
-0.018665133,
0.0064291013,
-0.006047771,
0.0060711857,
0.007211833,
0.013794805,
0.0041511524,
-0.02192986,
0.015132807,
-0.019227095,
0.013640935,
-0.024806565,
-0.010570219,
0.005137929,
0.020565096,
0.0046997336,
0.021234099,
-0.004478963,
-0.0027947526,
-0.019079914,
0.005004129,
0.0077336538,
0.01711305,
0.0034202687,
-0.0030891132,
-0.01573491,
-0.007907595,
-0.020284116,
0.013393404,
-0.017019391,
0.0057601,
0.0032061883,
0.013714525,
0.0036861966,
0.014102546,
0.037731666,
0.030399414,
0.00079778396,
-0.0075931638,
0.022746041,
-0.003850102,
-0.024632623,
-0.0037999267,
-0.003368421,
0.025930487,
0.017808812,
-0.0046930434,
-0.007934354,
0.014370146,
0.01075085,
0.023027021,
-0.0058370354,
0.019106675,
-0.0018113208,
-0.011841321,
0.02750933,
0.02316082,
0.020043276,
0.015654627,
-0.01719333,
-0.0051814145,
-0.008717085,
0.03877531,
-0.021140438,
-0.037544347,
-0.01667151,
-0.0059005907,
0.0032613808,
-0.019267235,
-0.024458684,
-0.022545341,
0.020912977,
-0.0075195734,
0.01672503,
-0.043190718,
0.006559557,
0.02841917,
0.0073523233,
-0.03783871,
0.01711305,
-0.0003564522,
0.0323529,
0.0017695082,
-0.030105054,
-0.007185073,
0.01100507,
0.017782051,
0.048114568,
-0.03917671,
0.026091047,
0.01708629,
-0.014049025,
0.006783672,
-0.0006163174,
-0.0010503319,
0.013306434,
0.0010369519,
0.014798307,
0.018491194,
-0.045732923,
0.008998066,
-0.007425913,
0.0042548478,
-0.006261851,
-0.018624993,
0.0008086552,
0.023856582,
-0.017527832,
-0.0010963257,
-0.01156034,
0.014932107,
0.0041210474,
0.020979878,
0.017889092,
-0.0076935138,
0.0052717295,
0.0038066169,
0.031496577,
0.015788428,
-0.0035925366,
0.02285308,
0.020324256,
0.0069375425,
-0.03179094,
0.014771546,
-0.008837506,
-0.00049422466,
0.017581351,
-0.0054088747,
0.014691266,
0.013072284,
0.006536142,
-0.009560027,
0.003388491,
-0.01130612,
-0.036473945,
0.0013672712,
-0.017929232,
0.026773429,
-0.005171379,
0.025448807,
-0.014490566,
-0.00019045628,
-0.03393174,
-0.026974129,
-0.02201014,
0.0025723097,
0.029676894,
-0.00022495165,
-0.02728187,
0.0074660536,
0.012617363,
0.004428788,
-0.0028516175,
0.012530393,
-0.0015152877,
0.013901845,
0.0067903623,
0.008081535,
-0.6538015,
-0.0058203107,
0.0065930067,
-0.029890973,
-0.0036861966,
0.02712131,
-0.0068907123,
-0.012784613,
-0.015119427,
0.00004818899,
-0.011553651,
0.0020421261,
0.0091720065,
-0.0029937804,
-0.026372027,
-0.01667151,
-0.007185073,
-0.005111169,
0.009560027,
0.0018715309,
-0.029141692,
-0.019039774,
-0.020351017,
0.019534836,
0.01657785,
-0.011894842,
0.01727361,
-0.0033901636,
-0.0045157582,
0.017955992,
-0.030693775,
-0.0009064966,
-0.016002508,
-0.012905033,
0.030693775,
0.004960644,
-0.002160874,
0.019481314,
0.0046863533,
0.041103434,
-0.028445931,
0.008763916,
0.010242408,
0.005121204,
-0.03906967,
0.008108295,
0.011506821,
-0.03791899,
0.006014321,
-0.012236032,
0.0018782208,
0.004980714,
-0.011854702,
-0.010215648,
-0.0095734075,
-0.0111188,
0.00557278,
0.0008007108,
0.0026057598,
-0.006716772,
-0.008636805,
-0.012704333,
-0.0010386243,
0.0016549417,
-0.01675179,
0.0004624471,
-0.012343072,
0.00026990016,
0.017848952,
-0.0011339571,
0.015801808,
0.02857973,
0.006566247,
0.0049271937,
0.005790205,
0.019401034,
0.024431923,
0.008161815,
0.002550567,
0.019160194,
0.00034955313,
-0.003853447,
-0.0151863275,
-0.0013538912,
0.0223045,
-0.0153067475,
-0.0097138975,
0.0069442326,
-0.0023297968,
-0.0017795432,
0.009566717,
0.0046562483,
0.0077135838,
-0.025381906,
-0.023053782,
0.017808812,
-0.0091720065,
0.008596665,
-0.000744682,
-0.015841948,
-0.017701771,
0.015159567,
-0.0013388386,
-0.0014249726,
0.014102546,
0.017487692,
-0.04402028,
0.010175508,
0.025462186,
-0.020190457,
-0.004512413,
-0.020471437,
-0.025074165,
-0.011453301,
0.0011924946,
-0.025836827,
0.0048368787,
0.007981184,
0.0091920765,
-0.02162212,
-0.0016909005,
-0.0225052,
0.014022266,
-0.0034788062,
-0.014129305,
0.010168818,
-0.019735536,
0.0013773062,
0.004579313,
-0.024043903,
0.019360894,
0.008349135,
0.008911096,
-0.020351017,
0.019039774,
0.01624335,
0.021876339,
-0.014169445,
0.0018581508,
-0.042414676,
-0.038106307,
0.004027387,
-0.0030155228,
-0.030024774,
0.011821251,
-0.016069409,
-0.024472063,
0.012670883,
0.0040641823,
-0.0034955314,
-0.0041712224,
0.012068782,
-0.005127894,
-0.002998798,
0.005054304,
-0.0008730466,
-0.029195212,
-0.03417258,
-0.0046261433,
0.000478754,
0.008610046,
0.012068782,
-0.01727361,
0.008442795,
-0.0217024,
-0.006683322,
0.0058972454,
0.0013196049,
-0.00066105684,
-0.015801808,
0.010035018,
0.009887838,
-0.028793812,
0.017889092,
-0.005907281,
0.0332895,
-0.0063153715,
-0.012597293,
-0.026385408,
-0.010148748,
0.008603356,
-0.015962368,
-0.0064023416,
-0.015948988,
0.041130193,
0.019869335,
0.025020644,
-0.007205143,
0.0012811373,
0.037490826,
0.01657785,
0.006546177,
-0.013768044,
0.016350389,
0.008422725,
-0.015413788,
0.013614175,
-0.013406784,
0.0004003554,
0.03320922,
0.031416297,
-0.005977526,
-0.0021859615,
0.0047733234,
-0.0031794282,
-0.004539173,
0.013293054,
-0.01641729,
0.0074794334,
0.027027648,
0.000036455338,
0.003960487,
-0.00039032038,
0.0052048294,
0.020391157,
-0.012416663,
-0.0068204673,
-0.0006016829,
-0.001978571,
0.02758961,
-0.008302305,
-0.026224848,
0.03949783,
0.005111169,
-0.01711305,
0.01132619,
0.007425913,
0.014503946,
0.018049652,
-0.0093727065,
-0.008710396,
0.028285371,
-0.0021341138,
-0.0090917265,
0.019401034,
0.021046778,
0.006646527,
-0.020003136,
0.041852716,
0.018785553,
0.003890242,
0.015721528,
0.026706528,
-0.014182826,
0.0096135475,
-0.006659907,
0.028793812,
0.021755919,
-0.00540553,
-0.0074392934,
-0.00031004025,
0.0018196832,
-0.010282548,
0.014289865,
-0.01139978,
0.0046495586,
-0.008944546,
0.008924476,
0.014691266,
0.030827576,
0.0024451993,
0.024980504,
0.0027194899,
-0.0005962473,
0.0029185177,
-0.0046595936,
0.0006434955,
-0.0042213975,
-0.020819318,
-0.016229969,
-0.020899598,
0.014517326,
0.017915852,
-0.01667151,
0.012517013,
-0.0042782626,
0.026679767,
0.013754665,
0.018611614,
0.018156692,
-0.020003136,
-0.010804369,
0.012450112,
0.018611614,
-0.0037196467,
-0.009700517,
0.000541891,
-0.012088852,
-0.008268855,
0.009861078,
-0.008937856,
0.0041912924,
0.009961428,
0.0090515865,
-0.012403282,
-0.031416297,
0.015480688,
-0.03299514,
0.020672137,
0.0027178174,
0.017099671,
0.0038668269,
0.014999007,
-0.010690639,
0.014677886,
0.0036126066,
0.0022127214,
-0.037383787,
-0.0051914495,
-0.018210214,
-0.02229112,
-0.012891653,
-0.0015487378,
0.00091653166,
-0.020912977,
-0.0010428056,
-0.013661005,
-0.01644405,
0.028445931,
-0.0010528406,
-0.01672503,
-0.013634245,
-0.019534836,
-0.041023154,
0.030345894,
0.03933727,
0.006609732,
0.012015262,
0.010369519,
0.0027713375,
-0.013681075,
-0.012343072,
0.024819944,
-0.005462395,
-0.0046027284,
-0.004097632,
0.0032045157,
0.0091720065,
-0.0026024147,
0.0040842523,
-0.0074995034,
-0.012450112,
0.004301678,
0.018772174,
-0.0011858046,
-0.01625673,
0.029007891,
0.048462447,
0.0098543875,
-0.021153819,
0.0154271675,
0.020203836,
0.010510009,
-0.017955992,
-0.007251973,
0.03454722,
0.012476873,
0.021046778,
0.011874772,
-0.019842576,
0.01617645,
-0.0015378665,
0.0098945275,
0.0059306957,
0.0046830084,
0.02202352,
-0.0063354415,
0.0044956882,
0.020337636,
-0.0145440865,
0.0040206974,
0.0052282442,
-0.014008885,
-0.017755292,
0.02817833,
-0.007278733,
0.00035728846,
-0.012744473,
-0.0071449326,
0.011654001,
-0.0070579625,
-0.016310249,
0.0047900486,
-0.0053051794,
0.012684262,
-0.026572729,
0.015547588,
-0.0031727382,
-0.0099346675,
-0.008897716,
-0.0034520463,
-0.014610986,
-0.02769665,
-0.011292741,
-0.023522083,
-0.021675639,
-0.029890973,
-0.018344013,
0.01569477,
0.036045786,
0.011292741,
-0.01083113,
0.0053185597,
0.01139978,
-0.0033165736,
-0.005455705,
0.007071343,
0.0038066169,
-0.009901218,
0.008850886,
0.0029703653,
-0.0083892755,
-0.012416663,
0.004519103,
0.006097946,
0.00024293106,
-0.018330634,
-0.014530706,
-0.015574348,
0.009218836,
-0.0045726234,
0.025662886,
-0.0015269952,
-0.019722156,
0.0076132338,
-0.036072545,
-0.008048085,
-0.0089512365,
-0.031657137,
-0.010001568,
-0.01620321,
0.012831443,
-0.009586787,
0.0074392934,
-0.006449172,
-0.014490566,
0.0038668269,
0.014316626,
0.036848586,
0.035457063,
-0.010844509,
0.0026743324,
-0.005121204,
-0.0035925366,
0.024378404,
-0.008041395,
0.024793185,
0.006235091,
-0.010342758,
0.014396906,
-0.0010168818,
-0.013112424,
-0.02857973,
0.018344013,
0.0090114465,
0.036072545,
-0.014276486,
-0.052021533,
-0.01128605,
-0.00553264,
-0.00560623,
0.018103173,
-0.0005168034,
-0.010195578,
0.011981811,
0.016939111,
-0.0005690692,
-0.029516334,
0.01661799,
-0.037865467,
-0.0023297968,
-0.0034955314,
0.014718027,
0.014075785,
0.005475775,
0.003082423,
-0.01102514,
-0.013018764,
0.004321748,
-0.042762555,
-0.012175822,
-0.023415042,
0.02783045,
0.020337636,
0.03821335,
-0.0023013642,
0.030640256,
0.026144568,
0.014637746,
0.014249725,
0.000085872576,
0.019213714,
-0.02817833,
0.018424293,
0.013373334,
-0.0064625517,
-0.019615116,
-0.024418544,
0.030399414,
0.038186587,
-0.028312132,
-0.013078974,
0.005060994,
-0.028526211,
-0.02226436,
-0.015119427,
0.006797052,
-0.006756912,
-0.006017666,
-0.013600795,
0.010704019,
0.010229029,
-0.013781425,
-0.03880207,
0.019106675,
-0.020498198,
0.018972874,
-0.02239816,
0.024204463,
-0.015560968,
0.0023849893,
-0.018651754,
-0.010449799,
0.0014258088,
0.0040106624,
0.018049652,
0.025984006,
0.0023582291,
-0.0049472637,
-0.010690639,
-0.014570846,
-0.021274239,
-0.009881148,
-0.012236032,
0.003391836,
-0.0012075471,
-0.011881461,
-0.017942613,
0.0070445826,
0.02162212,
-0.0018213558,
0.02259886,
0.0039537973,
-0.01136633,
0.0037029216,
-0.0022327916,
0.03291486,
-0.036875345,
0.03240642,
0.019374276,
-0.010088538,
-0.03256698,
-0.034681022,
0.0026458998,
-0.0029954528,
0.031924736,
0.01696587,
-0.020364396,
-0.017487692,
0.008275545,
0.023428421,
0.0066130767,
-0.03264726,
0.0025555845,
-0.0035590865,
0.0032965033,
-0.0025890346,
-0.0023782994,
-0.036126066,
0.018330634,
-0.013507134,
0.012028642,
-0.0007455182,
0.00016798203,
0.0009817593,
0.013661005,
-0.008248785,
0.03872179,
-0.0070378925,
0.0057266504,
0.0069776825,
-0.012142371,
-0.010041708,
0.00556609,
-0.00081409083,
0.01747431,
-0.00561292,
-0.010898029,
-0.003345006,
-0.005151309,
-0.0145440865,
-0.029543092,
-0.01637715,
0.036393665,
-0.0095131975,
-0.010322688,
-0.003927037,
0.028365651,
0.0155877285,
-0.023709403,
-0.017541211,
-0.013928605,
-0.023053782,
-0.008422725,
0.018611614,
0.009646998,
0.0059039355,
-0.010289239,
-0.019682016,
-0.003032248,
-0.017567972,
-0.026813569,
-0.001070402,
-0.052101813,
-0.01139978,
0.0020655412,
0.014370146,
0.02253196,
0.004883709,
-0.008255475,
0.0036895417,
0.029516334,
0.003284796,
0.006067841,
0.014771546,
-0.0036560916,
-0.02279956,
0.010469869,
-0.020966498,
-0.040247113,
0.0017594731,
-0.0225721,
-0.017139811,
0.0002945696,
0.010817749,
0.021916479,
-0.00018773846,
-0.02234464,
0.010162128,
0.024699524,
0.0034654262,
0.0052650394,
-0.036848586,
0.01137971,
-0.016778551,
-0.006833847,
0.018410914,
0.008108295,
-0.0031861183,
-0.006171536,
-0.021796059,
-0.0026860398,
-0.028285371,
0.0013204411,
-0.007198453,
0.012644122,
0.019347515,
0.018812314,
-0.0024418544,
0.003990592,
-0.014383526,
0.019146815,
-0.016979251,
-0.006161501,
-0.0042046728,
0.0029770553,
0.03219234,
0.03882883,
-0.0018665134,
0.0017761982,
-0.0026994199,
-0.046642765,
-0.046562485,
-0.002533842,
-0.013152564,
0.028285371,
0.02219746,
0.0047499086,
-0.018384153,
-0.009446297,
0.00080823706,
-0.033797942,
0.031443056,
-0.0015989129,
0.024257984,
0.013413474,
-0.002147494,
0.0150659075,
0.00052851095,
0.020324256,
-0.019280614,
-0.007238593,
0.025917107,
0.00022139758,
0.029329013,
0.0031142007,
-0.017648252,
-0.0020471436,
0.019869335,
0.000681545,
-0.012510322,
0.00067067373,
-0.004994094,
0.0085498355,
-0.009861078,
0.0033600586,
-0.0076935138,
0.01691235,
-0.008884336,
-0.014932107,
-0.0005841217,
-0.007900904,
-0.015534208,
-0.02724173,
0.00034223593,
-0.013246224,
-0.014811686,
0.014718027,
-0.043592118,
-0.0015579365,
-0.0001340093,
-0.019253854,
0.018277112,
0.03815983,
0.004385303,
-0.002809805,
0.023468561,
0.007639994,
-0.013681075,
-0.01121246,
-0.027027648,
-0.0034654262,
-0.014651126,
-0.0037664769,
0.012804683,
-0.010576909,
0.0008341609,
-0.03965839,
-0.003145978,
-0.0048602936,
0.002048816,
-0.013901845,
0.04292312,
0.017701771,
0.014932107,
-0.0032496734,
0.003947107,
-0.013052213,
-0.0051145144,
0.019093294,
0.013199394,
-0.021140438,
0.02201014,
-0.0094128465,
-0.013587414,
-0.0036192965,
-0.01613631,
-0.0030406106,
-0.020565096,
-0.0040240423,
0.18689218,
-0.0053152144,
0.00087973656,
0.041585114,
-0.0054021846,
-0.01629687,
0.013433544,
-0.0040842523,
-0.022786181,
-0.0009014791,
0.0063588563,
0.0065160715,
-0.01723347,
0.0026944024,
0.035965506,
-0.015373647,
-0.011787801,
-0.0017862332,
0.0004126901,
0.0035523963,
0.008683636,
-0.025074165,
-0.00029373335,
0.0031643757,
0.029329013,
0.008683636,
-0.04479632,
0.0009667067,
0.007934354,
0.0033266086,
-0.0049372287,
-0.018277112,
0.0014617676,
-0.002436837,
0.017460931,
-0.007619924,
0.008984686,
-0.023789683,
-0.019668635,
-0.003075733,
-0.012443422,
0.01651095,
0.0025455495,
-0.013453614,
0.021769298,
0.029623372,
0.0067903623,
-0.014918727,
-0.01111211,
-0.01680531,
-0.028124811,
0.0020605237,
0.010757539,
0.018571474,
0.0041210474,
-0.014530706,
0.003960487,
0.0053720796,
0.011874772,
0.03390498,
-0.02239816,
0.034252863,
-0.013654315,
0.0020588513,
-0.0077938642,
0.02182282,
-0.012296242,
0.019093294,
0.0049372287,
-0.023829823,
0.0008655203,
-0.011473371,
-0.029436054,
-0.0005025872,
-0.019842576,
-0.0058537605,
0.026545968,
0.026666388,
0.018290494,
0.013821565,
0.0003834213,
-0.01093148,
-0.02785721,
-0.004910469,
0.019093294,
-0.023027021,
0.045090683,
0.008663566,
0.0022127214,
-0.004994094,
0.00054649037,
-0.010382899,
-0.021060158,
0.013426854,
0.03256698,
-0.017367272,
0.011754351,
0.026024146,
-0.0017226781,
-0.008094914,
-0.018972874,
0.05111169,
0.025274865,
-0.0011214133,
-0.0034252862,
0.0003643966,
-0.028365651,
0.006131396,
-0.01096493,
-0.031282496,
0.010650499,
-0.000555271,
0.028954372,
-0.01107197,
-0.0010720744,
0.021314379,
0.009225527,
-0.053145457,
0.043378036,
0.00012616944,
-0.012175822,
-0.026840327,
0.01604265,
0.017246852,
-0.0032530183,
-0.02758961,
-0.0061982963,
0.00021930695,
0.0016716667,
-0.030105054,
0.0004415408,
-0.0030673705,
0.007807244,
0.018089792,
-0.005198139,
-0.023334762,
0.008288925,
0.0017494381,
-0.026077667,
-0.014704647,
-0.02201014,
-0.006271886,
0.01162055,
0.0034553912,
-0.0019568284,
-0.015948988,
0.015159567,
0.024137564,
-0.0330219,
-0.0036995767,
-0.016939111,
-0.017688392,
-0.0023833169,
-0.012650813,
0.007981184,
-0.008790676,
-0.030265614,
0.00044446767,
-0.012644122,
-0.006509382,
-0.018571474,
-0.007198453,
0.00544567,
-0.0074861236,
0.0015111065,
0.00553264,
-0.16976574,
-0.0037698217,
0.007205143,
-0.01711305,
0.015293367,
-0.000035592955,
0.005111169,
0.0085096955,
-0.018718654,
0.0051345844,
0.008188575,
0.018477812,
-0.057373542,
-0.026131187,
0.008790676,
0.023481943,
-0.025395285,
0.035028905,
0.024592483,
-0.0032764333,
0.036955625,
-0.029516334,
0.012523702,
-0.008917786,
-0.013179324,
0.04479632,
0.032540217,
-0.0111188,
0.0094529865,
-0.03759787,
-0.040461194,
0.013286364,
-0.007927665,
-0.004910469,
0.0040742173,
-0.005017509,
-0.020979878,
0.0025689646,
0.0036159514,
0.03280782,
0.0008947891,
0.010683949,
-0.014236346,
-0.0029720378,
0.00063889613,
0.034975383,
-0.0054423246,
-0.00061004545,
0.02730863,
-0.011332881,
0.03256698,
-0.01675179,
-0.0042983326,
-0.0014734751,
0.0075797834,
-0.0071047926,
0.003145978,
0.020203836,
0.015199707,
-0.021367898,
0.020739038,
-0.007051273,
0.040461194,
-0.0024067317,
-0.00138316,
-0.01116563,
-0.018504573,
0.02206366,
-0.018571474,
0.008074844,
0.014316626,
-0.018451054,
0.01115225,
-0.0111857,
0.035564102,
0.009366017,
-0.0056564054,
0.0059039355,
0.015788428,
0.0063889613,
-0.019454556,
0.034921862,
-0.024779804,
-0.023321383,
-0.008837506,
-0.0013806513,
0.008783986,
0.03232614,
-0.011841321,
0.0113195,
0.017380651,
-0.025288245,
0.023709403,
-0.00013244133,
0.01672503,
0.023923483,
-0.0019033084,
-0.0048803636,
0.008750536,
-0.0016482517,
0.028847331,
0.0076935138,
-0.01107197,
0.031228976,
0.02791073,
-0.014637746,
0.0104966285,
-0.0001875294,
0.04019359,
-0.005907281,
-0.012463492,
-0.008416035,
0.0043485076,
0.021528458,
-0.0052382792,
0.03417258,
-0.00065729365,
0.019775676,
-0.0028583077,
-0.020351017,
0.052637015,
-0.01095155,
-0.01644405,
0.012276172,
-0.0033667486,
-0.024886845,
-0.13958041,
-0.0068773325,
-0.0038333768,
0.042842835,
0.020203836,
0.024699524,
-0.015560968,
0.034681022,
-0.011546961,
0.03486834,
-0.013834945,
-0.007726964,
-0.017862333,
0.0046696286,
0.01672503,
0.0022595515,
0.007834004,
-0.0099948775,
-0.01708629,
0.04364564,
-0.0074995034,
-0.0089311665,
0.0040407674,
-0.005101134,
0.009586787,
-0.01158041,
-0.01629687,
0.0012451785,
0.017567972,
0.0115202,
0.0097741075,
-0.019253854,
-0.0033399884,
-0.014075785,
-0.035804946,
-0.0041544973,
-0.013794805,
-0.023709403,
0.025074165,
-0.036982387,
-0.011874772,
-0.006171536,
0.011740971,
0.01091141,
0.000957508,
0.009158626,
-0.026157947,
0.0062384363,
-0.023588981,
-0.013614175,
-0.028954372,
-0.0052516595,
0.008824126,
-0.012878273,
0.007191763,
-0.029168453,
0.018277112,
-0.032058537,
-0.013754665,
0.005810275,
-0.0076868236,
-0.0012443422,
-0.012670883,
0.0070178225,
0.008616735,
-0.02742905,
-0.065562114,
-0.013413474,
0.01119239,
-0.037811946,
-0.008302305,
0.019869335,
-0.012637433,
-0.0021441488,
-0.02841917,
-0.006569592,
-0.012149062,
0.0040307324,
-0.00053352845,
0.010637119,
-0.0074125333,
-0.024231223,
0.025194585,
0.0020722311,
0.018812314,
0.03318246,
0.012490252,
-0.02213056,
-0.0010871269,
0.0027613025,
-0.007185073,
0.02296012,
-0.0012652485,
-0.025609367,
-0.026907228,
0.008984686,
-0.0016942455,
-0.02249182,
0.040487953,
0.017621491,
-0.042093556,
-0.015547588,
-0.049318768,
0.030319134,
-0.008195264,
-0.0031509956,
0.01081106,
-0.011834632,
0.013901845,
0.0031576857,
0.0069643026,
0.023067161,
-0.019186955,
-0.0026375372,
-0.018277112,
-0.024351643,
-0.015480688,
-0.014075785,
0.018196832,
-0.008857576,
0.024712905,
0.03856123,
-0.015908848,
0.003361731,
0.01621659,
0.02279956,
-0.0002041499,
-0.010710709,
-0.001951811,
-0.014115925,
-0.004953954,
-0.013179324,
0.015239848,
-0.023522083,
0.0040608374,
0.013012073,
-0.006081221,
-0.01119908,
0.0023966967,
0.023910103,
0.029275492,
0.03291486,
-0.0085096955,
-0.032379657,
0.012443422,
-0.0058136205,
-0.00569989,
-0.0008638478,
-0.00034307217,
0.017166572,
0.0006727643,
-0.006124706,
0.031255737,
-0.007954424,
0.0010745832,
-0.02166226,
-0.007118173,
-0.008850886,
-0.018718654,
-0.014570846,
0.0023348143,
-0.003920347,
0.03872179,
-0.005010819,
0.0025689646,
-0.020016516,
0.010095228,
-0.01119239,
-0.028660012,
-0.0018347357,
-0.01569477,
-0.027295249,
-0.02154184,
-0.00022599696,
0.026010767,
0.008777296,
-0.024472063,
-0.007365703,
-0.013426854,
0.014891967,
0.007111483,
0.008308995,
0.023441803,
0.016350389,
-0.010048398,
0.01665813,
0.03318246,
0.009968118,
0.0002730361,
0.035965506,
0.00042753358,
0.019253854,
-0.017541211,
0.017260231,
0.017367272,
0.0023415042,
0.0011347933,
0.016149689,
-0.0035055664,
0.012436733,
-0.003028903,
0.02166226,
-0.010737469,
0.014744787,
0.015882088,
-0.026050907,
-0.002722835,
0.02817833,
-0.0015637903,
-0.041103434,
0.0091318665,
0.005907281,
0.007205143,
0.004315058,
-0.004512413,
0.01119239,
-0.028392412,
-0.0026492449,
0.007740344,
-0.0224383,
-0.011841321,
0.031309254,
0.0041946378,
0.017594732,
-0.007298803,
-0.03227262,
0.008121675,
-0.012282862,
0.04471604,
-0.019227095,
0.025796687,
0.014651126,
0.026184708,
-0.0006999425,
-0.018839074,
-0.02265238,
-0.00017383578,
-0.031924736,
0.004963989,
-0.0019334134,
-0.0031928082,
0.092108086,
-0.0032998484,
-0.026104426,
0.020672137,
-0.0315501,
0.036019024,
0.0035055664,
0.0017042806,
-0.015413788,
-0.023441803,
0.025315005,
-0.028606491,
0.008790676,
-0.020578478,
-0.013359954,
-0.0052282442,
-0.023829823,
0.01648419,
-0.0027813725,
-0.028606491,
0.021100298,
-0.02766989,
0.01569477,
0.034252863,
0.0046763183,
0.002580672,
0.014972247,
0.0018882559,
0.01604265,
-0.015092667,
0.002702765,
-0.010028328,
-0.03719647,
0.009366017,
-0.009185387,
0.018517952,
-0.0006409868,
-0.0112526,
0.01640391,
0.030747294,
-0.030051533,
-0.008937856,
-0.0058270004,
-0.008061465,
-0.01707291,
-0.006753567,
0.0013145873,
0.0032580358,
-0.03840067
] |
Microbe-macrophage interactions play a central role in the pathogenesis of many infections. The ability of some bacterial pathogens to induce macrophage apoptosis has been suggested to contribute to their ability to elude innate immune responses and successfully colonize the host. Here, we provide evidence that activation of liver X receptors (LXRs) and retinoid X receptors (RXRs) inhibits apoptotic responses of macrophages to macrophage colony-stimulating factor (M-CSF) withdrawal and several inducers of apoptosis. In addition, combined activation of LXR and RXR protected macrophages from apoptosis caused by | [
-0.015132049,
-0.003143559,
-0.011224838,
-0.01609878,
-0.038723007,
0.013514115,
-0.0046624704,
0.016944673,
0.0028464901,
-0.012211711,
0.027122216,
-0.011782052,
0.01291662,
-0.0009230953,
-0.009902295,
0.009680752,
0.036843248,
0.00033357306,
0.012158004,
0.0043368693,
-0.014836659,
0.017750282,
0.00540766,
-0.029136242,
0.0019636753,
0.010768326,
-0.0003954624,
-0.048632015,
-0.0075056036,
-0.011218125,
-0.00074351125,
-0.0018277286,
-0.021308396,
0.0022271771,
0.007290774,
-0.010533356,
0.02447713,
0.0035279023,
0.006226697,
-0.0065556546,
0.028626023,
0.010741472,
-0.002997542,
0.036870103,
0.012198284,
-0.00093400455,
0.0011882754,
-0.0101574045,
-0.02302703,
0.00059120054,
0.021791762,
-0.0065220874,
-0.0116075035,
-0.018676735,
0.0030025772,
0.011211411,
-0.021832041,
-0.004457711,
0.0042764484,
-0.008969129,
-0.014662109,
0.00008286878,
-0.017589161,
0.012607803,
-0.008015824,
0.028733438,
-0.00361182,
0.008881855,
-0.0063072583,
0.019428637,
0.04347611,
0.032090146,
0.0002574177,
0.016676135,
0.004286519,
-0.01554828,
-0.041676912,
0.006955103,
0.008398488,
0.0012545703,
0.022194566,
-0.00540766,
-0.002661871,
0.015695976,
0.031123415,
-0.018757295,
-0.008599891,
0.02065048,
0.026034642,
-0.017307198,
0.021979738,
0.013453694,
0.026410595,
0.034721807,
-0.010164118,
0.008311214,
0.017468318,
0.008928848,
-0.018529039,
-0.031177122,
-0.020731041,
0.00018912963,
-0.019831443,
-0.011184557,
-0.018730441,
0.007700293,
-0.007324341,
-0.0054580104,
0.029485341,
0.0067302035,
-0.017750282,
0.029673317,
0.0010917699,
-0.04559755,
0.024369715,
-0.011446381,
0.02069076,
-0.012413113,
-0.0075056036,
-0.006387819,
0.008035963,
0.024826227,
0.0052431813,
-0.012909907,
0.01134568,
-0.00022552896,
-0.013816219,
0.009385361,
-0.032117,
0.0029908286,
0.028733438,
0.00798897,
0.008042677,
-0.0048370194,
-0.011647784,
0.02247653,
-0.033513393,
0.007210213,
-0.013594676,
-0.014031048,
0.019092966,
0.03262722,
-0.016045073,
0.0045449855,
0.015924232,
0.019791162,
0.032654077,
-0.007653299,
-0.009331654,
0.022087151,
-0.004014625,
-0.0357691,
0.00979488,
-0.027793558,
0.011788766,
-0.0026937597,
-0.0028750221,
0.045033623,
-0.011849186,
-0.026356887,
0.003984415,
-0.027551876,
0.006099142,
0.012372833,
0.014339865,
0.031016001,
0.03297632,
0.038508177,
0.0007984774,
-0.003450698,
0.022275127,
0.028330633,
-0.018126234,
0.028142657,
0.0045416285,
0.01788455,
-0.011869326,
0.022771921,
0.0028246716,
-0.005276748,
-0.0070222374,
-0.000583648,
0.020543065,
0.0067570573,
-0.012238565,
-0.0010942875,
0.020744467,
-0.0217112,
0.003106635,
-0.020462504,
-0.00078505056,
0.03233183,
-0.014460707,
-0.018851284,
-0.6307392,
-0.02124126,
0.0053002452,
0.0019888508,
0.0042193844,
0.023147872,
0.0015692619,
-0.023483543,
-0.004954504,
0.027900973,
-0.03437271,
0.0039038537,
0.017911404,
-0.02438314,
-0.003937421,
-0.01992543,
-0.022489958,
-0.012695077,
0.010989869,
-0.006179703,
-0.0017488459,
-0.004954504,
-0.008667026,
0.019066112,
-0.028733438,
0.022073725,
0.030264098,
-0.0083582075,
0.01234598,
0.031391952,
-0.01079518,
0.020193968,
-0.006914823,
-0.003403704,
0.059292927,
0.009324941,
-0.014474134,
0.03625247,
0.023308994,
0.04049535,
-0.01780399,
0.010049989,
0.010533356,
0.0062904744,
-0.004236168,
0.0025947369,
0.0154274395,
0.02710879,
-0.00068476883,
0.0067067067,
-0.0020878736,
0.03845447,
-0.009660612,
-0.010540069,
0.019348077,
0.019092966,
0.022785347,
-0.01291662,
0.0022624226,
0.013285859,
-0.009016123,
0.013775938,
-0.01729377,
-0.020328237,
-0.030317806,
0.020744467,
-0.022973323,
0.00061092124,
0.006136066,
-0.0041186833,
0.019965712,
0.02773985,
-0.01187604,
0.0030932082,
-0.00749889,
0.034023613,
-0.014782951,
0.023577532,
-0.014017621,
0.039367497,
0.00061008206,
-0.018448478,
-0.03362081,
0.014715817,
0.029458487,
-0.0034221658,
-0.004957861,
-0.013514115,
-0.010063416,
-0.00043972902,
0.0072035,
-0.0042395247,
-0.026799973,
-0.03606449,
-0.015199183,
0.035715394,
-0.018032245,
-0.010775039,
0.0066462858,
-0.026719412,
-0.023053885,
0.011285259,
-0.001120302,
0.0071363654,
0.03963603,
-0.004873943,
-0.03582281,
-0.023147872,
0.03531259,
-0.03319115,
-0.0056661265,
0.017897978,
0.023872921,
-0.017817417,
0.012748784,
-0.018891564,
0.03319115,
0.01619277,
-0.0028045313,
-0.048148647,
0.037541445,
-0.015910806,
0.010654198,
-0.01370209,
0.017669722,
0.011862613,
0.02133525,
-0.015789963,
-0.007901696,
-0.013587962,
0.0041186833,
-0.0035211889,
0.014487561,
-0.015561707,
-0.0003251813,
0.008848287,
0.019992566,
-0.008948989,
-0.0061864164,
-0.034399565,
-0.05553341,
-0.0017471676,
-0.000843793,
-0.019401783,
0.00036273448,
-0.005206257,
0.00062938314,
0.0003990289,
0.014917219,
0.010224539,
0.02218114,
0.002302703,
0.012829346,
0.008955702,
0.022114005,
0.0005920397,
-0.013218724,
0.0071833595,
-0.012480248,
0.0031939095,
0.00045609297,
0.020193968,
-0.0012201641,
0.010533356,
-0.027632438,
-0.009492776,
0.033674516,
0.019052686,
0.0064549535,
-0.02902883,
-0.007250494,
-0.008673739,
-0.03719235,
0.001276389,
-0.0024856438,
0.0077405735,
-0.015695976,
0.007686866,
0.010432655,
-0.0071095116,
0.02702823,
-0.012574236,
0.0076935794,
0.003531259,
-0.0055519985,
0.018582746,
0.02124126,
-0.012312412,
0.015051488,
0.029807584,
-0.019952284,
0.03399676,
-0.015951086,
0.03311059,
0.011708205,
-0.023886349,
0.0063475384,
0.018461905,
0.014917219,
0.025940655,
-0.0005970748,
-0.037541445,
0.025779532,
-0.031714197,
0.0008173589,
-0.015011207,
-0.005004855,
-0.006109212,
0.025215605,
-0.003900497,
-0.0068040513,
-0.0023748723,
-0.0021734696,
-0.0361182,
0.0118357595,
0.0058641722,
0.027712997,
-0.003692381,
-0.011701491,
-0.034426417,
-0.004236168,
-0.011849186,
0.018126234,
-0.006770484,
-0.008344781,
0.01635389,
0.0046322597,
0.016004793,
-0.032654077,
-0.0071229385,
-0.0051089125,
-0.014393573,
0.004212671,
0.0052834614,
0.018260503,
0.01831421,
-0.017683148,
-0.007451896,
0.020543065,
-0.0023144516,
0.0022573874,
-0.002495714,
0.008418629,
0.0197106,
-0.012486962,
-0.006434813,
0.028384339,
0.025954083,
-0.0007082658,
0.009311514,
-0.011681351,
0.015575134,
-0.015669122,
-0.0074451827,
-0.0010321883,
0.0012990468,
0.0060252943,
0.012520528,
0.049303357,
0.009902295,
0.015414013,
-0.025591558,
-0.0058071082,
-0.027444461,
0.007089372,
0.025470715,
-0.0026266256,
-0.007525744,
-0.0076801525,
-0.010479649,
-0.031284537,
-0.0055519985,
0.019952284,
-0.021066712,
0.010446082,
-0.00059162016,
0.032278124,
0.0069752433,
0.01062063,
-0.013030748,
-0.0069081094,
-0.030076122,
0.03233183,
0.016434452,
0.0077271466,
-0.013003895,
-0.044550255,
-0.008566324,
0.006548941,
0.021482944,
0.030774318,
0.007700293,
0.0030663547,
-0.00022133307,
-0.020972725,
-0.004826949,
0.036843248,
-0.031016001,
0.018435052,
-0.009714318,
0.023684947,
-0.005370736,
0.0012587663,
0.00096505415,
0.016931245,
-0.008472336,
-0.0019603188,
-0.022597373,
-0.0054680808,
-0.017052086,
-0.0015633877,
-0.0068711853,
0.0030713896,
-0.010768326,
0.004007912,
0.008035963,
-0.0350172,
0.025014203,
0.008841574,
0.002524246,
-0.009828447,
-0.029861292,
0.008297787,
-0.01623305,
0.038642447,
0.012352693,
-0.006344182,
0.009177245,
0.008848287,
-0.006156206,
0.0064247428,
-0.024866508,
0.026840253,
0.0016498229,
-0.00698867,
0.003531259,
-0.020193968,
0.010177545,
0.028357487,
0.009902295,
0.0053539523,
-0.022301981,
-0.02689396,
-0.028438047,
0.0064113163,
-0.0010775039,
0.025873521,
0.01682383,
0.013373133,
0.0015818496,
-0.0004967931,
0.008136665,
0.006391176,
-0.03378193,
0.01703866,
0.012721931,
-0.0049612173,
0.0118290465,
-0.006226697,
-0.030264098,
0.0012587663,
-0.007176646,
-0.0059917276,
0.0061494927,
-0.0020308096,
0.02294647,
0.01568255,
-0.00590781,
0.020287955,
-0.006589222,
-0.0036554572,
0.011983455,
-0.004363723,
-0.011755198,
0.018784149,
-0.009841874,
-0.006079002,
-0.011426241,
-0.00491758,
-0.009680752,
-0.0039307075,
0.007465323,
-0.011775339,
-0.008673739,
-0.007928549,
-0.033728223,
0.018408198,
-0.003304681,
0.004746388,
-0.0058138217,
-0.016340464,
-0.024920216,
-0.03190217,
0.0038098658,
0.031418804,
-0.019348077,
-0.0091436785,
0.030640049,
0.009754599,
0.012950188,
0.008432056,
-0.019750882,
0.006981957,
0.03480237,
-0.020757895,
0.00003582239,
0.0064213863,
-0.03147251,
0.029565902,
-0.018555893,
0.009875441,
-0.021080138,
-0.02341641,
0.00877444,
0.0018260502,
-0.011990168,
0.018690161,
0.006283761,
-0.022825629,
0.010284959,
-0.0018193368,
0.023376128,
-0.0007938619,
-0.013285859,
0.0036957378,
-0.026585143,
-0.03289576,
-0.019818015,
-0.023429835,
-0.02795468,
0.009271233,
0.014621829,
-0.028035242,
-0.00773386,
0.006797338,
-0.00097428507,
-0.00018126234,
0.015669122,
0.0026031286,
0.02579296,
0.0134066995,
0.030478926,
0.015306598,
-0.009318227,
-0.017011806,
-0.0034288792,
0.0108556,
0.024611399,
-0.019307796,
-0.006260264,
-0.014245877,
-0.0066832094,
-0.017575733,
-0.010593777,
-0.028035242,
0.01911982,
0.012218424,
-0.039260082,
-0.029941853,
0.013339566,
-0.0069081094,
0.01678355,
-0.005857459,
-0.01823365,
-0.01366181,
0.008136665,
0.0021113707,
-0.0041153263,
0.03482922,
-0.03751459,
0.006374392,
0.027189352,
-0.01801882,
0.007827848,
0.0000054382635,
-0.025685545,
-0.031929027,
0.00035392313,
-0.034319002,
-0.032358684,
0.0019972424,
-0.017468318,
0.041408375,
0.017924832,
0.016421026,
0.0006969369,
0.013896779,
-0.0074854633,
0.02302703,
-0.003309716,
0.0027122216,
0.008056104,
-0.015105195,
0.020663908,
-0.008834861,
0.0060118674,
0.0006381945,
-0.013205297,
0.008620031,
0.025873521,
-0.010869027,
-0.018341064,
-0.004464424,
-0.008828147,
-0.03012983,
0.009157105,
-0.011453095,
-0.016394172,
-0.03764886,
0.002755859,
0.031042853,
-0.0009046334,
0.0054815076,
0.006589222,
0.008687166,
-0.022624226,
0.024369715,
-0.011379247,
0.0005488221,
0.003981058,
0.010996582,
0.0048907264,
-0.001753881,
0.0027206135,
-0.003427201,
0.00025909606,
0.00900941,
-0.02940478,
0.01729377,
-0.019495772,
-0.013567822,
-0.01321201,
-0.018448478,
-0.01984487,
-0.014823232,
0.0031737692,
0.015776537,
-0.043234427,
-0.017683148,
0.016595574,
-0.0012738714,
0.01848876,
-0.012513815,
-0.0350172,
0.03297632,
0.0013317748,
0.018837856,
-0.034426417,
0.011265119,
0.015749684,
-0.007431756,
-0.018475331,
0.0053606657,
-0.009512916,
-0.01136582,
0.023926629,
0.045329012,
-0.027310193,
-0.0068040513,
-0.020569919,
-0.006112569,
-0.0046926807,
-0.018005393,
0.014796378,
0.01038566,
0.010761612,
-0.005877599,
-0.0175086,
-0.03990457,
0.007639872,
-0.03386249,
-0.00877444,
0.0066295024,
-0.0015306597,
-0.0076465853,
0.007854701,
0.010311813,
-0.018529039,
0.010768326,
-0.020301383,
-0.007277347,
-0.030022414,
0.009405501,
0.008828147,
-0.008042677,
0.032278124,
0.008848287,
0.025121618,
-0.0016506622,
0.01525289,
-0.0036621706,
-0.013540968,
0.001857939,
0.040441643,
0.0055385716,
0.0035346157,
0.0005408499,
0.021885749,
-0.0016305218,
-0.03692381,
0.007928549,
-0.004756458,
-0.0037528018,
-0.0057231905,
0.015951086,
0.001432476,
-0.024503984,
-0.0015071628,
-0.028008388,
-0.01576311,
-0.017871125,
-0.0108556,
0.015239463,
-0.021550078,
0.016716415,
-0.0058306055,
0.013990767,
0.023188153,
0.013326139,
0.009452496,
-0.016461305,
0.009103398,
-0.03525888,
0.028518608,
-0.006112569,
0.0056896233,
-0.015991367,
0.016649282,
-0.011983455,
-0.04967931,
0.008552897,
-0.025336448,
-0.03896469,
-0.027135644,
-0.015534854,
-0.0012344301,
0.02043565,
-0.014903792,
0.016165916,
-0.007935262,
0.0009868727,
0.011412814,
-0.0053438824,
0.026276326,
-0.009110111,
0.01132554,
0.020798175,
0.000012004172,
-0.016689561,
-0.008781154,
0.009116825,
0.0017236706,
0.009613617,
-0.0032409036,
-0.006374392,
0.015400586,
-0.025484143,
-0.008338068,
-0.014299585,
-0.016609002,
-0.02970017,
0.01992543,
0.014890365,
-0.016582148,
-0.009546483,
0.001800875,
-0.006810765,
0.00049469515,
-0.012527241,
0.01568255,
0.0063374685,
-0.013843073,
-0.013581249,
0.016770123,
-0.04726248,
0.045704965,
-0.014205596,
0.0018680091,
-0.006515374,
-0.0059783007,
-0.024436848,
-0.022060297,
-0.00822394,
0.015736256,
-0.0064549535,
-0.0007493855,
0.0011521907,
0.005118983,
-0.004857159,
-0.003143559,
0.0047027506,
-0.017025232,
0.0049108667,
-0.010996582,
0.04390577,
-0.014138463,
-0.0154274395,
-0.007874842,
0.04283162,
-0.00046532392,
-0.024450276,
0.026665704,
-0.008801294,
0.002066055,
-0.003215728,
-0.0054949345,
0.010372234,
0.00093736127,
0.032278124,
-0.008197086,
0.007539171,
0.041703764,
-0.00038979796,
0.0057097636,
-0.0021919317,
0.008411915,
0.026356887,
0.017924832,
0.013366419,
-0.024302581,
0.03458754,
-0.021402383,
0.026021216,
0.0049343635,
0.004736318,
0.0017605944,
0.0032073364,
-0.034184735,
-0.0056057055,
-0.0009667325,
-0.0034188093,
-0.0016053466,
0.0028397767,
0.0051693334,
-0.008472336,
-0.008176945,
0.009076544,
-0.014715817,
0.010479649,
-0.025658691,
0.004028052,
-0.009002697,
0.010882454,
0.0130710285,
0.009687465,
-0.020704187,
0.0011991847,
-0.015615415,
-0.013245578,
0.02247653,
0.0046020495,
-0.0038904268,
0.008485763,
0.020368516,
0.011882753,
-0.0024554334,
-0.013802792,
-0.024571117,
0.0008110651,
0.041435227,
0.18410884,
-0.022704786,
-0.0056560566,
0.012822633,
-0.01619277,
-0.011171131,
-0.008257506,
-0.0032694356,
-0.0175086,
0.02324186,
0.026061496,
0.009486062,
-0.014420426,
-0.00009341095,
0.008915422,
-0.0071565057,
-0.017347477,
-0.009183958,
-0.015293171,
-0.022543665,
0.018247075,
0.011426241,
0.005857459,
-0.0046591135,
0.04809494,
0.012513815,
-0.029351072,
0.01652844,
0.007002097,
-0.004286519,
-0.014460707,
0.003010969,
-0.0025208893,
0.015440866,
0.0058406754,
0.0066597126,
-0.020099979,
-0.008640172,
0.013547681,
-0.012970327,
-0.0028179581,
0.011338967,
-0.008344781,
0.009425642,
0.0004980519,
0.001640592,
-0.0021902532,
-0.036521006,
-0.008720732,
0.01134568,
-0.038266495,
0.00902955,
-0.014326438,
0.008942275,
0.004075046,
-0.01780399,
0.00773386,
0.016421026,
-0.013138163,
0.014044475,
0.0035178321,
0.011802193,
-0.03458754,
0.021187553,
-0.019066112,
0.04291218,
-0.0028968407,
-0.002576275,
0.0076331585,
-0.016810404,
-0.010526642,
0.0024973922,
-0.030237244,
-0.024503984,
-0.0053170286,
-0.004524845,
0.0033416047,
0.01780399,
0.03034466,
0.01911982,
0.00983516,
-0.0048437323,
-0.043100156,
0.0049813576,
-0.010768326,
-0.03072061,
0.018287357,
0.01002985,
-0.03190217,
0.0032341902,
0.004430857,
-0.008761013,
-0.0052263974,
-0.03144566,
0.017011806,
-0.015964514,
0.001915003,
0.0037997956,
-0.005266678,
-0.0020408798,
-0.048041236,
0.081903726,
-0.022207994,
-0.018542467,
-0.012990468,
0.013017321,
-0.0012025414,
0.019160101,
-0.0019536053,
0.01988515,
0.023510396,
-0.011956601,
-0.009828447,
-0.0046121194,
0.0024386498,
0.024020618,
0.015803391,
-0.0076331585,
0.023402981,
0.0014198883,
-0.020999579,
-0.006042078,
0.006079002,
0.007941976,
-0.0029153028,
-0.008546184,
-0.04648372,
-0.016555294,
-0.011963314,
-0.024074323,
0.005810465,
-0.0046624704,
0.00035539168,
0.004075046,
0.006434813,
-0.007465323,
0.04326128,
-0.026437448,
-0.009351794,
0.021563506,
-0.033513393,
0.011191271,
-0.00040490314,
0.009512916,
0.010096984,
-0.012856199,
0.0055385716,
0.03437271,
-0.012688364,
0.00036042673,
-0.021899177,
-0.002363124,
-0.02014026,
0.0025729183,
0.019280942,
-0.027431034,
-0.017871125,
-0.027296767,
0.023711799,
0.0052868184,
-0.032573514,
-0.007317628,
0.0043368693,
-0.017374331,
-0.0055385716,
-0.0050753457,
-0.16917819,
-0.0014492596,
0.016515013,
-0.015320024,
0.045436427,
0.0061327093,
-0.01546772,
0.006146136,
-0.0108287465,
0.008344781,
0.045973502,
-0.0004900797,
-0.044899352,
-0.01362153,
0.019388357,
-0.0076801525,
0.0104863625,
0.025175326,
0.014125036,
0.01801882,
0.05276748,
-0.03525888,
0.0006239285,
-0.01289648,
0.013722231,
0.012728645,
0.004884013,
0.009996283,
0.005370736,
-0.011909607,
-0.025954083,
-0.000023759214,
0.01609878,
0.001366181,
0.030854879,
0.002378229,
0.011265119,
0.006095785,
-0.00015545763,
0.011231552,
0.030049268,
0.025376728,
-0.021268114,
0.013265718,
-0.018985553,
0.016434452,
0.006270334,
-0.011258406,
0.017723428,
-0.0093048,
-0.007102798,
-0.022543665,
-0.0001120302,
0.0217112,
0.022624226,
0.009042976,
0.0033718152,
0.022060297,
-0.012204997,
-0.0016674458,
-0.0036185335,
-0.02133525,
0.027712997,
0.003073068,
0.018676735,
-0.02290619,
0.0056996937,
0.013775938,
-0.014407,
0.002128154,
-0.014286158,
-0.0029203377,
0.027001375,
-0.01652844,
0.0335671,
0.019603187,
-0.0073109143,
0.010533356,
0.01601822,
0.006887969,
-0.0036521005,
-0.0019502485,
-0.030666903,
-0.010405801,
-0.026101777,
0.007955403,
0.02473224,
-0.0010246357,
-0.006317328,
-0.009956002,
0.033486538,
-0.03480237,
-0.018636454,
-0.010674338,
0.023805788,
0.029458487,
-0.009506203,
-0.007626445,
-0.0180591,
0.02145609,
-0.0022422823,
-0.014903792,
-0.002136546,
0.008868428,
0.020046271,
-0.025779532,
-0.034131028,
-0.007894982,
0.05408331,
-0.027525023,
-0.011016722,
-0.006797338,
0.0019720672,
0.026934242,
-0.002633339,
-0.009788167,
0.018555893,
-0.009002697,
-0.0066865664,
-0.028921414,
0.06401917,
0.0041018995,
-0.014514415,
0.014970927,
0.005998441,
-0.029968707,
-0.13383874,
-0.03144566,
-0.003209015,
-0.002354732,
-0.02349697,
0.023215007,
-0.005384163,
0.006122639,
-0.00012451297,
0.005263321,
-0.020408796,
-0.003403704,
-0.011010009,
-0.028545462,
-0.0010053347,
-0.003588323,
0.01597794,
-0.0019838156,
-0.0051424797,
0.03568854,
0.013655096,
-0.03343283,
0.003148594,
0.0033634235,
0.015226036,
-0.0010044954,
-0.013574535,
0.011855899,
0.0061159255,
0.013567822,
0.009909008,
0.00023182279,
0.021053284,
-0.008398488,
-0.007941976,
-0.013963914,
0.0033147512,
-0.018126234,
0.02553785,
-0.013165017,
0.00361182,
0.017790563,
0.03050578,
-0.012513815,
0.009392074,
0.0029639748,
-0.02867973,
0.0017790563,
0.019495772,
-0.0050518485,
-0.022973323,
-0.012748784,
-0.03327171,
-0.010573637,
0.034426417,
-0.010237966,
0.0020979438,
0.04318072,
-0.02065048,
0.007834561,
0.017481746,
-0.010869027,
-0.029485341,
0.017213209,
0.020207394,
-0.03633303,
0.0042059575,
-0.030290952,
0.0021768264,
-0.016595574,
0.004638973,
-0.00012640111,
0.00013353412,
-0.00023475991,
-0.013507402,
0.010902594,
-0.017495172,
-0.012037162,
-0.007176646,
-0.014621829,
-0.0045315586,
-0.017723428,
0.012325839,
-0.013527541,
0.025618412,
0.0106004905,
0.00977474,
0.012674937,
-0.002055985,
-0.011594077,
-0.017589161,
0.03238554,
0.0026870463,
-0.014621829,
-0.0070222374,
-0.008385061,
0.0032912542,
-0.004726248,
0.010660911,
0.010660911,
-0.0041253967,
-0.0060353647,
-0.057037216,
0.020099979,
-0.015414013,
0.008841574,
-0.0047631715,
-0.018475331,
0.0021566863,
-0.034990344,
0.012379547,
0.020569919,
-0.019401783,
0.014420426,
0.005484864,
0.013245578,
-0.024208592,
-0.018770723,
0.021348676,
-0.0083582075,
0.013540968,
0.01848876,
-0.0019787806,
-0.0062099136,
0.007384762,
0.0034607681,
-0.0068208347,
0.01470239,
-0.0040582623,
0.01691782,
-0.01886471,
-0.012862912,
-0.0030076122,
-0.032788344,
-0.02404747,
0.009418928,
-0.02583324,
-0.021576932,
-0.004756458,
0.034936637,
0.017119221,
0.037326615,
-0.019092966,
-0.034641247,
-0.0020022774,
-0.018287357,
0.02102643,
-0.0030092904,
-0.02149637,
0.011338967,
-0.011285259,
-0.020207394,
0.027632438,
0.0008912065,
-0.030559488,
-0.034184735,
-0.029377926,
-0.008438769,
-0.0009482706,
-0.030049268,
-0.019133247,
-0.020543065,
0.007384762,
0.042079717,
0.0019066113,
-0.0073310547,
0.017468318,
-0.030640049,
-0.008781154,
0.00413211,
0.013963914,
-0.02867973,
-0.03332542,
0.006676496,
-0.00849919,
-0.0015617093,
0.0045751957,
-0.004931007,
-0.0023648022,
-0.0026518009,
-0.0112718325,
-0.0051592635,
-0.008129952,
-0.022557091,
-0.032224417,
0.008975843,
0.012144577,
0.004850446,
-0.029753877,
0.016125634,
-0.014568121,
0.008714019,
-0.0005148354,
0.019415211,
0.019871723,
-0.0016909427,
0.015185756,
0.013057602,
-0.001513037,
-0.003830006,
-0.016743269,
0.026356887,
0.0037427316,
0.013883352,
-0.016300185,
-0.028518608,
-0.002425223,
0.0200597,
-0.03504405,
-0.039716594,
-0.01079518,
0.009452496,
0.014044475,
0.032492954,
-0.003997842,
-0.0063710357,
-0.008928848,
0.024638252,
0.0036621706,
-0.006444883,
-0.0028532036,
0.021388955,
0.04033423,
0.032278124,
-0.008526043,
-0.015991367,
0.0009507881,
0.0026434092,
0.031579927,
-0.022664506,
0.03525888,
-0.0038602166,
0.031418804,
-0.00898927,
-0.05735946,
-0.003333213,
-0.012124437,
-0.010674338,
0.01907954,
0.03627932,
-0.01213115,
0.07094742,
0.010231252,
-0.029163096,
0.0009004375,
-0.013279145,
0.027269913,
-0.0032308334,
0.025752679,
-0.00796883,
-0.027444461,
0.023295568,
-0.007290774,
0.017991966,
-0.033969905,
-0.0357691,
0.006481807,
-0.017172929,
0.0104930755,
0.016850684,
-0.023228433,
0.014407,
0.0011849187,
0.015830245,
0.010775039,
-0.03340598,
0.0018764009,
0.049330212,
-0.0009969429,
0.012258705,
-0.016541867,
-0.00006744889,
0.010143978,
-0.016112208,
0.0029891504,
0.005380806,
-0.010217825,
-0.013869925,
-0.005223041,
0.00617299,
0.013238864,
-0.008620031,
0.004779955,
-0.014004194,
-0.02889456,
0.0028112447,
0.011130851,
-0.022785347,
-0.00798897,
-0.023564104
] |
The sequence-specific binding to DNA is crucial for the p53 tumor suppressor function. To investigate the constraints imposed on p53-DNA recognition by nucleosomal organization, we studied binding of the p53 DNA binding domain (p53DBD) and full-length wild-type p53 protein to a single p53 response element (p53RE) placed near the nucleosomal dyad in six rotational settings. We demonstrate that the strongest p53 binding occurs when the p53RE in the nucleosome is bent in the same direction as observed for the p53-DNA complexes in solution and in co-crystals. The p53RE becomes inaccessible | [
-0.026925717,
-0.015857598,
-0.008452019,
-0.022377726,
-0.034398373,
0.03654492,
0.0051684766,
-0.004933698,
-0.023276592,
0.014328184,
0.003047087,
0.01348969,
0.02282045,
0.022686291,
-0.012758523,
-0.011175447,
0.02913934,
-0.024081545,
-0.011410225,
0.008371524,
-0.012651196,
-0.02913934,
-0.00828432,
-0.017762655,
0.010035095,
0.0064362795,
0.0060237404,
-0.035015505,
-0.012718276,
-0.019761624,
0.0029833612,
0.011302898,
-0.0074458257,
0.00520537,
-0.006785093,
0.00078063784,
0.004769353,
-0.01230909,
0.0022672876,
-0.018178549,
0.015267298,
0.008062958,
-0.016340569,
-0.006037156,
-0.0080964975,
-0.014609918,
0.007982462,
-0.016327154,
-0.015602695,
0.002626163,
-0.007942215,
0.018071221,
-0.03270797,
0.0036658954,
-0.009095982,
-0.015642943,
0.015119722,
0.014234273,
0.0030655337,
-0.027395273,
-0.02088856,
-0.006181377,
-0.0074927816,
0.007942215,
-0.0039711073,
0.014234273,
0.007150676,
0.005369715,
-0.006593916,
-0.007304959,
0.039711073,
0.036035113,
-0.0103772,
0.008914867,
0.01745409,
-0.016421065,
-0.0072378796,
0.018446866,
-0.013804964,
0.0027066583,
0.022015497,
-0.011047996,
-0.004685504,
0.016192995,
0.008438603,
-0.004849849,
-0.01070589,
0.015066058,
0.009283804,
-0.0011554447,
0.017869983,
0.03584729,
0.01954697,
0.0098741045,
-0.040462364,
0.011276066,
0.018621273,
0.022739954,
-0.0034277632,
-0.022015497,
-0.0067347833,
0.0050209016,
-0.013093921,
-0.0049169282,
-0.01522705,
0.0019771687,
-0.012711568,
-0.014851404,
-0.008176993,
-0.003561922,
-0.017118692,
0.03579363,
-0.0145025905,
-0.028575873,
0.0415088,
-0.01879568,
0.023947386,
-0.0026295169,
-0.0072915433,
-0.0058761653,
0.030400435,
0.022793619,
0.020123854,
-0.03300312,
0.021384949,
-0.00006498328,
-0.029353995,
-0.017588248,
0.0023058583,
0.0056581567,
0.02125079,
0.045721397,
0.0029347287,
0.0038738418,
-0.00795563,
0.013952538,
-0.002074434,
-0.023102185,
-0.017360179,
-0.0468215,
0.013147584,
0.01745409,
-0.021452028,
-0.029219836,
0.04011355,
0.020834897,
0.01909083,
-0.0008812571,
0.018782264,
0.0043165665,
0.0054334407,
-0.007076889,
0.019895783,
0.016327154,
0.0034981966,
-0.007278127,
-0.020164102,
0.02347783,
-0.031607866,
-0.04043553,
0.011108368,
0.0021716992,
-0.0077678077,
0.02200208,
0.027153786,
0.027851414,
0.0071439683,
-0.008083081,
-0.0025926232,
-0.008693505,
0.005691697,
0.009947891,
-0.032359157,
0.0054032546,
-0.014703829,
-0.023893723,
0.009330761,
0.025678037,
-0.025517046,
-0.00065612147,
-0.010142422,
0.0026848575,
0.019654298,
0.027583096,
-0.01968113,
-0.012288967,
0.014837989,
-0.025074322,
0.0017356824,
0.008431895,
-0.0010497944,
-0.013778132,
0.004387,
-0.0022236858,
-0.64138746,
0.004085142,
0.014247688,
-0.03077608,
0.00191512,
0.030105285,
0.013080505,
0.02527556,
-0.015549031,
0.025986603,
0.014489175,
0.0048833885,
0.008505682,
-0.020794649,
-0.048672896,
-0.030963903,
0.0018849344,
-0.0072714193,
0.0421796,
-0.009075858,
-0.012584116,
-0.0042897346,
-0.0037094972,
0.015830765,
0.020298261,
0.006201501,
-0.011202279,
-0.028710032,
0.009116106,
0.026831806,
-0.031903017,
0.024591349,
-0.010866881,
0.0143416,
0.046687342,
-0.004417186,
-0.0049102204,
0.012859142,
0.0356863,
0.03107123,
0.017467504,
0.005108105,
0.015991757,
0.0010674028,
-0.039040275,
0.011658419,
-0.009820441,
0.013677512,
-0.0076671885,
0.011450473,
0.0023226282,
-0.014274521,
-0.01188649,
-0.007177508,
0.026187843,
0.007479366,
0.015871013,
-0.029327163,
0.011276066,
-0.017266266,
0.020767817,
-0.01100104,
-0.00095923705,
-0.045855556,
-0.015897844,
0.0039207977,
-0.0036088778,
0.03270797,
0.0015570832,
-0.0064362795,
0.019010333,
0.0057319445,
0.008599593,
-0.0038906117,
0.021693515,
0.039281763,
0.012496913,
0.013724469,
0.0008523291,
0.01456967,
0.007948922,
-0.010933961,
-0.044809114,
0.0049269903,
0.024282783,
-0.0122956745,
-0.01581735,
0.04073068,
0.002475234,
-0.018607857,
0.004963884,
-0.01702478,
-0.014797741,
-0.02766359,
-0.011940153,
0.0155222,
-0.0007089466,
0.008800833,
0.016971117,
-0.019520137,
-0.019399395,
-0.0016426096,
-0.0017474213,
-0.001380161,
0.012778647,
0.011946862,
-0.023236344,
0.011115075,
0.03533749,
-0.011309606,
0.0060170325,
0.0032131088,
-0.02095564,
-0.0047022738,
-0.012517037,
-0.029810136,
0.0012535484,
0.028066069,
-0.011658419,
-0.004547991,
-0.0021800841,
0.00959237,
-0.015790517,
-0.024108376,
-0.0034579488,
0.008183701,
0.026214674,
0.0050309636,
0.011470596,
-0.005134937,
0.009578954,
-0.013187832,
0.021921584,
-0.020311676,
0.020553162,
0.0019905847,
0.030695586,
0.00067372987,
0.014314768,
-0.029997958,
-0.033056784,
0.003857072,
0.008264196,
0.020834897,
-0.008686797,
-0.020781234,
-0.03463986,
0.004799539,
0.003037025,
-0.00068043784,
0.013657389,
0.0077946396,
-0.012456666,
0.025101153,
0.007593401,
-0.014609918,
-0.022015497,
-0.024108376,
-0.00066492567,
-0.02295461,
-0.0015352824,
-0.0018715184,
-0.018017557,
-0.0073452066,
-0.006882358,
-0.030239444,
0.013033549,
0.013563477,
-0.003726267,
-0.044782285,
0.0031762149,
-0.019573802,
-0.02452427,
-0.020405589,
0.00015795129,
0.009525291,
-0.009216725,
-0.00221027,
0.0021633143,
0.0053495914,
-0.005409963,
-0.011410225,
-0.0029615606,
-0.01073943,
0.014234273,
0.015777102,
0.014086698,
0.0011906613,
0.00023855153,
0.0013231434,
0.00021255821,
0.00231592,
0.0008070504,
0.021277621,
0.01077297,
-0.023880307,
0.012798771,
0.011202279,
-0.010149131,
0.03759136,
0.010638811,
-0.022605795,
0.016179578,
-0.015562447,
0.0045546987,
0.0044641416,
-0.015656358,
-0.035900954,
0.010779678,
0.006191439,
-0.01411353,
-0.009357592,
-0.0009189893,
-0.0014841342,
0.0032466485,
0.032788467,
-0.011289482,
0.013617141,
-0.000005885834,
0.003719559,
-0.008337984,
0.0062652268,
0.041857615,
-0.00033120508,
0.0037329749,
-0.0040918505,
0.008881328,
-0.00828432,
0.022270398,
-0.009706406,
-0.007888551,
0.011282774,
-0.014006202,
0.002052633,
0.0022337479,
0.005225494,
0.014019618,
-0.007586693,
0.03176886,
-0.010008263,
-0.019520137,
0.0020979117,
-0.019868951,
-0.012000524,
0.025221897,
-0.0050242557,
0.02897835,
0.015267298,
-0.009042318,
0.0080964975,
-0.020445835,
-0.0033975774,
-0.025007242,
0.024779173,
-0.0032080777,
0.0000589042,
0.013952538,
0.024671845,
0.032305494,
0.01804439,
0.018903006,
0.01044428,
0.0040616645,
-0.016407648,
0.021438612,
-0.010471112,
0.026724478,
-0.0034847807,
0.0052858656,
0.018071221,
-0.0021448673,
-0.007861719,
-0.00032994736,
-0.026228089,
-0.005889581,
0.006194793,
-0.003706143,
0.029005181,
0.0027049815,
0.008411771,
0.006503359,
-0.03316411,
0.04250158,
0.035122834,
-0.0074458257,
-0.019171325,
-0.004688858,
-0.0073854546,
0.021237373,
0.013664097,
0.0138586275,
-0.0015327669,
-0.019573802,
0.021800842,
-0.01597834,
-0.011712083,
0.02265946,
-0.029032012,
0.015777102,
-0.021935001,
0.025892692,
-0.01745409,
-0.012496913,
-0.003729621,
0.035015505,
0.01613933,
0.021747177,
-0.015267298,
-0.01404645,
-0.01984212,
-0.011369977,
0.005114813,
-0.0030621798,
-0.013737884,
-0.018446866,
-0.0024232473,
0.007016517,
0.00050225784,
0.019050581,
-0.0008393324,
-0.021438612,
-0.023759564,
0.0042897346,
0.014462343,
0.025329225,
0.031983513,
0.0029414366,
0.00772756,
-0.011081535,
0.017266266,
-0.0061478373,
-0.031849355,
0.01784315,
-0.010330245,
-0.0023243052,
0.0036524795,
-0.0048867427,
0.008928283,
-0.0003580369,
0.018245628,
0.012584116,
-0.04338703,
-0.01850053,
0.000621324,
-0.02027143,
-0.0058124396,
0.021223959,
0.04191128,
0.025624374,
-0.009062442,
0.010685766,
0.013315284,
0.017038196,
-0.026228089,
0.0010766262,
0.020097023,
0.021197125,
0.04368218,
0.0056011393,
-0.028924687,
0.029541818,
0.0026462867,
0.0087404605,
-0.0064094476,
0.0018681644,
-0.0033875154,
0.016823541,
0.011168739,
0.028039236,
-0.0045110974,
0.0131542925,
0.003040379,
-0.031554203,
-0.0043735844,
0.020325093,
-0.027100123,
-0.0078013474,
-0.010417448,
-0.009203309,
0.0021851151,
0.0012325861,
-0.023290006,
-0.0047592917,
-0.029944295,
-0.008230656,
-0.0036893731,
0.024765756,
-0.0025322516,
0.009672866,
-0.009753361,
-0.01993603,
-0.007868427,
-0.030427268,
-0.029702809,
-0.00992106,
-0.029702809,
-0.032010343,
0.00221027,
0.036652245,
0.018191963,
0.0154014565,
-0.0037564528,
-0.007714144,
-0.013221372,
-0.0056044934,
-0.015267298,
-0.015267298,
-0.017668745,
-0.008344691,
0.011698667,
0.03048093,
-0.015790517,
-0.0167028,
0.026201257,
-0.003444533,
-0.0024416943,
0.034532532,
0.020808065,
-0.010793094,
0.03743037,
0.0010959115,
0.04639219,
0.008398355,
0.0057084667,
-0.009015487,
-0.018513946,
-0.011188863,
-0.010799802,
0.0023092122,
-0.021559356,
0.0013960924,
0.0068555265,
-0.01345615,
-0.0071439683,
0.004021417,
-0.021492276,
-0.00609082,
0.011195571,
0.0356863,
0.020392172,
0.005513936,
0.019600634,
-0.010907128,
-0.0022002081,
-0.018071221,
-0.012436542,
0.02913934,
-0.013382363,
-0.013536646,
0.004551345,
-0.0017373594,
-0.02684522,
-0.0082910275,
0.00026496407,
0.0034780728,
0.046311695,
-0.0013122429,
-0.0104979435,
-0.009713113,
-0.0014355016,
-0.00039241515,
0.008606302,
-0.0019100892,
-0.0048464946,
-0.00965945,
-0.0013491367,
0.010343661,
-0.023665652,
-0.011128491,
-0.024712093,
-0.02347783,
0.041401476,
-0.013690929,
0.0037229129,
-0.001587269,
-0.019600634,
0.0027200743,
-0.021975249,
-0.022095991,
-0.025369471,
0.006744845,
-0.003291927,
0.044996936,
0.033539757,
0.038771957,
-0.0028274015,
-0.0021029427,
0.032439653,
0.008156869,
-0.007197632,
-0.018326122,
0.015951509,
-0.011551092,
0.0034210552,
-0.002599331,
-0.01791023,
-0.0074189943,
0.0015243819,
0.013375655,
0.022042328,
-0.013281744,
-0.011229111,
0.008934991,
-0.038074333,
-0.032895792,
-0.0013625526,
-0.019815288,
0.0087203365,
-0.03136638,
-0.0007600947,
0.008197117,
0.006174669,
0.0021767302,
0.013711053,
0.016944285,
-0.003296958,
0.024537686,
0.009391132,
0.014368432,
-0.022417974,
-0.019922616,
0.0020912038,
0.0077879312,
0.027234282,
0.010397324,
0.012174931,
0.016421065,
0.00854593,
-0.008814248,
-0.0015847535,
-0.019748209,
-0.008995363,
-0.0094246715,
-0.01178587,
-0.016300322,
0.0023075351,
-0.0025389595,
-0.012416418,
-0.021881336,
-0.010082051,
-0.006744845,
0.0077476837,
0.0073988703,
0.0021683453,
0.013134168,
-0.0054334407,
0.029032012,
-0.0030487638,
0.005919767,
0.019359147,
0.0017591602,
-0.017856566,
-0.026630567,
-0.017440673,
0.019037167,
0.02534264,
0.017735824,
-0.032788467,
-0.008458727,
-0.005346237,
-0.0029867154,
-0.015200217,
-0.014422095,
0.016260074,
-0.027234282,
-0.000096636424,
-0.0065536685,
0.010846757,
-0.0050242557,
0.0054401485,
-0.03107123,
0.027381858,
-0.023719316,
-0.005648095,
-0.028173396,
-0.014153778,
-0.020834897,
0.022364309,
-0.0021062966,
-0.01411353,
0.011993817,
-0.003441179,
0.018849343,
0.0046117166,
-0.019063998,
0.033995897,
-0.008485558,
-0.012288967,
0.01656864,
0.0058962894,
-0.006456403,
0.005507228,
-0.0006238395,
0.032359157,
-0.012356047,
-0.0064329254,
0.023343671,
0.009230141,
-0.010591855,
0.038557306,
-0.019788457,
-0.011074828,
-0.015052643,
0.0007454211,
0.0153612085,
0.018983502,
0.0023058583,
-0.013093921,
-0.009089274,
0.014878236,
-0.023182679,
0.003578692,
0.014100114,
-0.035605807,
-0.023893723,
0.0043635224,
0.022055743,
0.0392281,
0.010920545,
-0.004004647,
0.005953307,
0.02897835,
-0.027475769,
0.0052590338,
0.020714154,
0.0016577025,
-0.03257381,
0.011463889,
-0.0207544,
-0.017937062,
0.008324567,
-0.008458727,
-0.0037899925,
-0.018473698,
-0.016367402,
0.017534584,
0.03139321,
-0.014596502,
0.013764716,
-0.0019637528,
0.034371544,
0.0076470645,
-0.011309606,
0.009350884,
0.0014707183,
0.0121481,
0.018057805,
-0.013482982,
-0.029461322,
0.010417448,
-0.019667713,
0.03150054,
0.004407124,
-0.004588239,
-0.018876174,
-0.019063998,
-0.010538192,
-0.00007216288,
-0.0015319284,
-0.0018279167,
-0.011752331,
0.025302391,
0.008230656,
-0.00051986624,
-0.016058836,
-0.0030722418,
0.009880812,
0.0022991502,
-0.022874113,
-0.006610686,
0.020834897,
-0.030132117,
-0.04282356,
-0.013684221,
-0.024349863,
0.022203319,
0.025758533,
-0.03048093,
-0.011618172,
-0.0018463637,
-0.04432614,
0.013617141,
0.006768323,
0.0026295169,
0.024846252,
0.011437057,
-0.0039543374,
0.02216307,
0.003957691,
0.039469585,
0.014073282,
-0.025463384,
0.014945315,
-0.026670814,
0.04384317,
0.018903006,
-0.022471637,
0.012416418,
0.019292068,
-0.01355677,
-0.024806004,
0.02841488,
-0.0030537948,
0.018084636,
-0.012188348,
-0.005359653,
0.010752846,
0.04550674,
0.0126847355,
-0.0073988703,
-0.011544384,
-0.0010120622,
0.011007749,
-0.018473698,
0.008237364,
0.004004647,
0.0105449,
0.0021649913,
-0.005775546,
-0.038288984,
0.005671573,
-0.006848818,
0.012054188,
0.01568319,
0.011993817,
0.016555224,
0.004651964,
-0.009807025,
-0.0026815035,
-0.03133955,
-0.043628514,
-0.0064161555,
-0.009156354,
-0.023155848,
-0.02718062,
-0.0074860738,
0.003984523,
-0.0017859921,
0.007868427,
-0.02102272,
-0.008277612,
-0.044352975,
0.010041803,
0.005634679,
-0.003474719,
-0.002894481,
-0.018473698,
-0.02681839,
-0.00910269,
0.015830765,
0.0029296977,
-0.0063792616,
0.0030605027,
-0.024349863,
-0.025074322,
0.0066442257,
0.0016342247,
0.01411353,
-0.02600002,
0.012349338,
0.20027259,
-0.009572246,
-0.0027033044,
0.0012837342,
0.009357592,
-0.010960792,
-0.0131945405,
-0.008955115,
0.000028141952,
-0.010819926,
0.006593916,
0.0053026355,
-0.022176487,
-0.0072110477,
0.033325102,
0.00003052642,
-0.018996919,
-0.011866366,
-0.017655328,
0.0064161555,
0.026939133,
0.000514416,
0.01329516,
-0.0009508521,
0.03404956,
-0.005279158,
-0.02659032,
-0.0016711183,
-0.017413842,
0.016018588,
-0.024443775,
-0.00034923272,
0.011624879,
-0.0037765766,
0.013650681,
-0.0025288977,
-0.0015914615,
-0.028146563,
-0.007043349,
0.015066058,
0.0016308706,
0.013939123,
-0.0094246715,
-0.008995363,
-0.0018547486,
-0.0036155859,
0.0027385212,
-0.008458727,
0.00033434946,
0.016716214,
-0.016649134,
-0.00992106,
0.012154807,
0.018326122,
-0.0022857345,
-0.020794649,
0.035069168,
-0.0105180675,
0.0035082586,
0.022391142,
-0.035122834,
-0.001716397,
-0.027261114,
0.0020224473,
-0.012906099,
0.018648105,
-0.006976269,
0.025718285,
0.037242547,
-0.022176487,
0.003283542,
0.00025930424,
-0.001780961,
0.0033355288,
-0.018259043,
-0.015307545,
0.05422708,
0.014395264,
0.06927972,
0.020445835,
0.009766777,
0.011678543,
-0.031903017,
-0.008411771,
0.004641902,
-0.014381847,
0.028441714,
0.004859911,
-0.014596502,
0.004940406,
0.018312708,
-0.010907128,
-0.016313737,
-0.0063054743,
0.011148615,
-0.0022874114,
-0.03238599,
0.019359147,
-0.032198165,
-0.0133689465,
-0.012362754,
0.06804546,
-0.021760594,
0.0098338565,
-0.007157384,
0.0027871537,
0.017789487,
0.01188649,
0.013979371,
-0.0032684493,
0.014744077,
-0.0073384987,
0.0044943276,
-0.0057017584,
0.016783293,
0.012825603,
-0.009458211,
-0.023061937,
0.01836637,
0.002042571,
-0.011772455,
-0.033325102,
-0.0015009041,
0.024242535,
-0.01791023,
0.016528392,
-0.03133955,
-0.0076470645,
-0.009142938,
-0.030078454,
-0.0004900997,
0.0032516795,
0.0035485062,
0.0115913395,
-0.010813218,
-0.02600002,
0.023061937,
-0.02154594,
-0.01613933,
0.023786396,
-0.0069695613,
-0.009713113,
0.02059341,
0.021867922,
-0.02216307,
-0.026657399,
-0.0037698688,
0.014247688,
-0.011141907,
0.008465434,
-0.005943245,
-0.0012401325,
0.0026295169,
-0.0046284865,
-0.011148615,
-0.013321991,
-0.017896814,
-0.046445854,
-0.017789487,
0.034881346,
-0.031124894,
0.009196601,
0.0093844235,
-0.023222927,
0.004705628,
0.0029330517,
-0.16968434,
0.02652324,
0.03523016,
-0.02229723,
0.021291038,
0.014596502,
0.021036135,
0.0069829775,
-0.021438612,
-0.0034109931,
-0.0010975886,
0.007687312,
-0.039281763,
-0.0137513,
-0.007479366,
-0.0036860192,
0.010202794,
0.024470607,
0.010008263,
0.017199187,
0.006600624,
-0.014529423,
0.013597017,
-0.004812955,
0.015374624,
0.018004142,
-0.014998979,
-0.0136238495,
0.012255427,
0.006204855,
0.0022807035,
0.012349338,
0.037671853,
-0.02956865,
0.015964923,
0.0037933465,
-0.0028391404,
0.005671573,
-0.007412286,
0.019104246,
0.023142433,
0.014301352,
-0.0035317363,
-0.0009793609,
-0.0043199207,
0.033673916,
0.008270904,
-0.0017340054,
0.023021689,
-0.0033975774,
0.02157277,
-0.011430349,
0.026201257,
0.025302391,
0.032010343,
-0.018701768,
0.0004169411,
0.022578964,
-0.017574832,
-0.012416418,
0.00047374907,
-0.026040267,
0.051382907,
-0.014770909,
-0.022377726,
-0.027556265,
-0.018634688,
0.015629526,
-0.035632636,
-0.019493306,
-0.015763685,
-0.017105276,
0.009411256,
-0.0016032003,
0.012221888,
0.013315284,
-0.004413832,
-0.000967622,
0.006184731,
-0.016514976,
-0.010484528,
0.0069158976,
-0.014381847,
-0.025691453,
-0.007056765,
-0.007439118,
-0.014220857,
0.024014466,
-0.0014740723,
0.008572762,
0.03107123,
-0.018379787,
0.021062966,
-0.008378231,
0.012979886,
0.025785364,
-0.00017430192,
0.0027837998,
-0.0286832,
-0.0025943,
0.027301362,
-0.022968026,
-0.01404645,
0.0138183795,
0.029353995,
0.0076537724,
-0.004823017,
0.0017474213,
0.03987206,
-0.012047481,
-0.0082910275,
0.0035719841,
0.014945315,
0.021331286,
-0.009847272,
0.02766359,
0.011477305,
0.007325083,
-0.002882742,
-0.035122834,
0.059834927,
0.013409195,
-0.015589279,
-0.008270904,
-0.0087203365,
-0.02913934,
-0.13501765,
-0.018460281,
-0.0047760615,
0.008405063,
-0.0051550604,
0.0023863537,
0.0055307057,
0.026885469,
-0.0013625526,
0.018473698,
-0.018755432,
-0.017145524,
-0.009585663,
-0.015280713,
-0.022927778,
0.010685766,
0.0023829998,
-0.018648105,
-0.01827246,
0.03936226,
0.0036457716,
0.0019872305,
0.0036625415,
-0.010558316,
0.021639852,
-0.009941184,
-0.016823541,
-0.0013860305,
0.0041086203,
-0.00687565,
-0.010095467,
-0.022672875,
0.007559861,
-0.0066509335,
-0.022364309,
-0.0017306515,
-0.023625404,
-0.009807025,
0.025517046,
-0.010102174,
0.0055810157,
-0.0066442257,
0.009444796,
0.0040918505,
0.0018346247,
-0.011946862,
-0.016850373,
0.016112499,
0.032332323,
0.018607857,
-0.025503632,
-0.002626163,
-0.02645616,
-0.018084636,
0.0153612085,
0.0122755505,
0.023370503,
-0.008955115,
-0.027381858,
0.010618687,
0.0013214664,
-0.0103235375,
-0.02141178,
0.0027150433,
0.03780601,
0.008908159,
-0.025879277,
-0.018849343,
0.015763685,
-0.022874113,
0.0033590067,
0.006328952,
-0.011866366,
0.005262388,
-0.03254698,
-0.009008778,
-0.03670591,
-0.029219836,
0.018084636,
-0.010558316,
0.0046083624,
-0.008881328,
0.014475759,
-0.021854505,
0.026442744,
-0.0031057815,
-0.001595654,
-0.005664865,
0.015549031,
0.0025691453,
-0.014998979,
0.04338703,
-0.017628497,
-0.0087605845,
-0.01836637,
0.015964923,
-0.006063988,
-0.02884419,
0.008680089,
0.011859658,
-0.0339154,
0.008948407,
-0.04073068,
0.014891651,
-0.015642943,
0.005373069,
-0.008411771,
-0.0062417486,
0.021961832,
-0.0013851919,
-0.0037363288,
0.0012870881,
-0.0056044934,
0.0016937577,
-0.014301352,
-0.02288753,
-0.02577195,
-0.018916423,
0.025074322,
-0.021505691,
-0.0043601682,
0.030507762,
-0.02295461,
-0.004450726,
0.008733752,
0.0057386523,
-0.015629526,
-0.021800842,
-0.033325102,
0.00992106,
-0.0087605845,
-0.0068555265,
-0.0021113276,
-0.03107123,
-0.021130046,
0.008619717,
0.0012024003,
-0.021116631,
-0.015790517,
0.01886276,
0.023209512,
0.018460281,
-0.02838805,
-0.036491256,
-0.029005181,
0.011148615,
0.0050175474,
0.00943138,
-0.046419024,
-0.008653257,
0.0017407134,
-0.010175962,
0.022417974,
0.010383909,
0.0125103295,
-0.01709186,
-0.010786385,
0.006466465,
-0.010699183,
0.0021230667,
-0.0028575873,
-0.01895667,
0.016192995,
0.008237364,
0.01797731,
-0.0010933961,
0.0027100123,
0.006060634,
-0.020915393,
0.0022488406,
-0.007412286,
-0.017306514,
-0.033351935,
0.008190408,
0.0011311283,
-0.0051282286,
0.0019855537,
-0.0014891652,
-0.008559346,
0.0009206663,
-0.011953569,
0.013308575,
0.019198157,
-0.007553153,
-0.003947629,
-0.00551729,
0.023746148,
0.00018530716,
0.001162991,
-0.0050376714,
0.026107347,
0.0023511369,
-0.0046184245,
0.024792587,
0.0019251821,
0.036947396,
-0.0058392715,
0.017494338,
-0.021237373,
0.000034666482,
0.023370503,
0.020445835,
-0.009968015,
-0.009666158,
-0.0077476837,
-0.011738915,
-0.0029800073,
0.031715196,
-0.0066911816,
-0.044084657,
-0.0071104285,
0.0074726576,
0.014368432,
0.010229626,
0.01456967,
0.012000524,
-0.0231156,
0.013161001,
0.003592108,
-0.00007577889,
0.007908675,
0.01827246,
0.013268327,
0.0010757877,
-0.005913059,
-0.006053926,
0.031151725,
-0.013060382,
0.030722417,
-0.02007019,
0.027287945,
-0.03120539,
0.0334056,
-0.009947891,
-0.020767817,
-0.0074189943,
-0.0034881346,
-0.010598563,
-0.001921828,
0.030507762,
-0.010826633,
0.08307127,
0.0207544,
-0.020137269,
-0.0016350631,
-0.036357097,
0.015173386,
0.0067079514,
0.005788962,
0.0073452066,
-0.030427268,
0.0339154,
-0.027448937,
0.021733763,
-0.021116631,
-0.02265946,
0.029273499,
-0.013268327,
0.010974208,
-0.0012342631,
-0.012859142,
0.011047996,
-0.013073797,
-0.008123329,
0.014770909,
-0.03241282,
0.0017306515,
0.0008330437,
0.021331286,
0.005007486,
-0.02520848,
0.008384939,
-0.00009438297,
-0.042152766,
0.0060505723,
0.019439643,
-0.0076403567,
-0.0034646569,
-0.016474728,
0.0059700767,
0.032895792,
0.011812702,
0.012979886,
-0.012242011,
-0.019278653,
0.001032186,
0.0041891155,
0.015039227,
-0.023008274,
0.0061444836
] |
The genetically obese (ob/ob) mouse exhibits defective thermoregulatory responses to cold exposure. Pathophysiological explanations for this phenomenon have focused on abnormalities in intracellular metabolism or insensitivity of peripheral tissues to the thermogenic effects of catecholamines. Because the sympathetic nervous system (SNS) is subject to feedback regulation, a peripheral impairment in thermogenesis should be associated with a compensatory increase in SNS activity. To examine SNS activity in the ob/ob mouse, norepinephrine (NE) turnover was measured in heart and interscapular brown adipose tissue (IBAT) of ob/ob and | [
-0.04009969,
-0.011981006,
-0.0039551198,
-0.02413383,
-0.026896134,
0.01360006,
-0.010170307,
0.004543266,
-0.031085853,
-0.009853105,
0.008465343,
0.0044011855,
0.0049067275,
0.00006907829,
-0.012033872,
-0.006129279,
0.03544739,
0.009046881,
0.008201008,
-0.0047382135,
-0.032671865,
0.02486075,
0.0038394728,
-0.003485924,
0.013011914,
-0.003092725,
0.0075599947,
-0.04440836,
-0.0026499631,
-0.012793837,
0.016216982,
0.0011754668,
-0.024807885,
-0.014036214,
-0.0024004965,
-0.010157091,
-0.0096548535,
-0.022825368,
0.021860544,
-0.012622019,
0.018014463,
0.005551045,
-0.010791495,
0.02957914,
-0.008822196,
-0.0015215811,
0.014882088,
-0.033041935,
0.005686517,
0.012569152,
0.008828805,
0.01810698,
-0.008075449,
0.004117025,
-0.011392859,
0.022666767,
-0.00536601,
0.013639711,
-0.0012019004,
-0.03600249,
0.0072824424,
-0.0023294564,
-0.031032985,
0.019283272,
-0.0117563205,
-0.023869494,
0.0025838793,
0.0029423842,
-0.0065687364,
0.0051181954,
0.027028302,
0.024807885,
-0.00946321,
0.007084191,
0.006733946,
-0.008828805,
-0.021279005,
0.033491306,
0.003125767,
0.0009863017,
0.017565092,
-0.030900817,
-0.015344675,
0.034205012,
0.019402225,
0.009582161,
-0.0152653735,
-0.0038031267,
0.011326775,
0.0012514633,
0.010256217,
0.014022997,
0.01933614,
-0.00016851387,
-0.016851386,
0.008538036,
0.013474501,
0.025323339,
-0.024517115,
-0.003720522,
-0.010659328,
0.017142156,
-0.00831335,
-0.02409418,
-0.024926836,
0.0026450069,
-0.009839888,
-0.0005278449,
0.012813662,
-0.011789362,
-0.012265166,
0.034892283,
-0.012820271,
-0.009681287,
0.014644185,
0.0036742631,
0.0145516675,
-0.00046382615,
-0.0046093496,
-0.03499802,
0.013837962,
0.03084795,
0.0077516376,
0.008300134,
0.016679568,
0.0005138021,
-0.009905972,
-0.0041864133,
-0.026592148,
-0.0046027415,
-0.0061391913,
-0.003092725,
0.0041269376,
0.02158299,
-0.016970338,
0.030583614,
-0.01728754,
-0.006132583,
-0.015886562,
-0.031191586,
0.009846496,
0.028548231,
-0.028495364,
0.020512434,
-0.0073419176,
0.03219606,
0.006152408,
0.016071597,
-0.004606046,
-0.019613693,
-0.007850763,
-0.019071804,
0.018358098,
-0.021688726,
0.013011914,
0.020882502,
0.0028416063,
0.019838378,
-0.019759078,
-0.028653966,
0.017023204,
-0.009086532,
0.0035850499,
-0.0054717446,
-0.0061458,
0.010573419,
0.005960765,
-0.008557861,
0.028521799,
-0.0076789455,
-0.0059178104,
0.026949001,
0.0007322919,
0.023499424,
0.0018470441,
0.025706625,
-0.020499216,
0.010163699,
0.0068066386,
-0.011914922,
-0.029103335,
0.014842437,
0.0025062307,
0.015040688,
-0.00225346,
-0.0056468667,
0.0015414063,
-0.015833694,
0.011095482,
-0.00782433,
-0.0067042084,
0.017128939,
-0.01802768,
0.0020766857,
-0.6411721,
-0.005772426,
0.006400223,
-0.014512017,
-0.016111247,
0.010606461,
0.0144195,
0.0014563233,
-0.015688311,
0.023050053,
-0.010639503,
0.00245832,
0.017908728,
-0.037482772,
-0.012212299,
-0.020472782,
-0.008736287,
0.002679701,
0.006132583,
-0.003466099,
-0.006205275,
-0.00645309,
0.0059012896,
0.021886978,
0.022547817,
0.0072031417,
0.014115514,
-0.014155164,
0.0061094537,
0.031191586,
-0.0033421917,
0.012542718,
0.018358098,
-0.004150067,
0.05022374,
-0.0038526896,
-0.015291807,
0.03600249,
0.0053527933,
0.036161095,
-0.02720012,
-0.011333384,
0.015661877,
-0.004110417,
-0.03068935,
0.021715159,
0.0009706068,
0.0117563205,
-0.0001461073,
-0.002683005,
0.013864396,
0.012139606,
-0.0048109055,
0.02146404,
0.016441667,
-0.006747163,
0.018344883,
0.004678738,
-0.0068528973,
0.020182014,
0.0067042084,
0.029817041,
-0.013309292,
-0.03592319,
-0.016071597,
0.03150879,
-0.022111662,
0.02630138,
0.0026086606,
-0.018701734,
0.025151521,
0.021120405,
-0.012311425,
0.03941242,
0.012668278,
0.01007779,
0.013586843,
0.010930272,
-0.017327191,
0.004989332,
-0.0077516376,
0.0144195,
-0.01048751,
-0.018331666,
0.022058796,
-0.018899987,
-0.0011077309,
0.02421313,
-0.0071700998,
-0.017076071,
0.0010969922,
0.0037866058,
-0.03272473,
-0.026882919,
-0.00794989,
0.03195816,
-0.01028265,
0.009839888,
0.01634915,
-0.012615411,
-0.032143194,
0.021873761,
0.00143402,
-0.003621396,
0.027385155,
0.0036247002,
-0.01933614,
0.0066711665,
0.031535223,
-0.016520968,
0.008511602,
-0.0151596395,
-0.00884863,
0.0044276193,
-0.016150897,
-0.0145516675,
0.025125086,
-0.010064573,
0.0006306879,
-0.024530333,
0.023684459,
0.0073022675,
0.013401808,
-0.028257463,
0.016335933,
0.021609426,
-0.0009491296,
-0.030451447,
-0.020221664,
-0.03227536,
-0.0033901024,
0.00088221964,
0.004133546,
-0.01933614,
0.03211676,
0.010646111,
0.01769726,
0.00010656024,
0.018648868,
-0.020644601,
-0.022349564,
-0.013956913,
-0.006558824,
0.0011490333,
0.0073485263,
0.0017809602,
0.018794252,
-0.0015975775,
0.011729887,
0.016481318,
-0.022706417,
-0.006258142,
0.00082109205,
0.009522686,
0.023301173,
-0.015595793,
-0.020327399,
-0.004754734,
-0.007566603,
-0.0019114759,
-0.00044193587,
0.0041269376,
-0.0125757605,
0.029314805,
-0.037165567,
-0.021622641,
-0.0026053565,
0.0041071125,
-0.028336763,
-0.026724316,
-0.009350867,
-0.01802768,
0.0053693145,
-0.0008987406,
-0.0034198402,
0.0055708704,
-0.005795555,
-0.022838585,
-0.0056799087,
-0.0097605875,
0.0136264935,
-0.001196944,
-0.0121131735,
0.005418877,
0.042663746,
0.0015851868,
0.01073202,
0.0038361687,
0.0027259595,
0.013719011,
-0.020076279,
0.015688311,
-0.010355342,
0.007883806,
0.022468515,
-0.03354417,
0.036689766,
0.021027887,
0.021027887,
0.036557596,
0.009813455,
-0.03121802,
0.029922776,
-0.026486415,
0.012132999,
-0.027808093,
0.01888677,
-0.017208239,
-0.0025574458,
-0.0012894615,
-0.0018652172,
0.02241565,
0.0055378284,
-0.021437608,
0.0036742631,
0.015476842,
0.005944244,
0.007143666,
0.02241565,
-0.025323339,
-0.016084814,
0.000098041615,
0.016811736,
-0.013097823,
-0.010989747,
0.02470215,
0.027015086,
0.0032876725,
-0.0003382668,
0.0041731964,
0.0073088757,
0.0011655543,
-0.0076789455,
-0.012060306,
0.0005509743,
-0.0028928213,
-0.0038559937,
-0.018212715,
0.01818628,
0.029843476,
0.025270471,
0.0062548383,
0.01687782,
-0.027596625,
-0.019124672,
-0.0011556416,
0.0094235595,
0.016785303,
-0.025838792,
0.0027044823,
0.000019799347,
0.002303023,
-0.0065026525,
0.030054944,
0.008967581,
0.002595444,
0.008267092,
0.000040631254,
0.041606404,
0.020340614,
0.0059938068,
-0.008062232,
-0.0013216774,
-0.022389214,
0.013249815,
0.00080828834,
0.0071833166,
0.00802919,
0.0227725,
-0.009390518,
-0.024543548,
0.009198874,
-0.023697676,
-0.027015086,
0.038487244,
0.0019428658,
0.030054944,
0.014776353,
0.04218794,
0.01687782,
-0.0027953477,
-0.027173687,
0.02019523,
0.0023509336,
0.003449578,
0.016230198,
-0.018093763,
0.008789155,
-0.009331042,
0.011981006,
0.004665521,
-0.0025524895,
0.009621811,
-0.002595444,
-0.025085436,
-0.00700489,
0.014882088,
-0.03637256,
0.03272473,
-0.0055213072,
0.015542926,
0.01962691,
-0.02126579,
-0.016243415,
0.023829844,
0.018754601,
0.010461076,
-0.012734362,
-0.00005632617,
0.00037998226,
0.0003913404,
-0.021292223,
0.0050653284,
-0.023591941,
-0.017300757,
0.00074716075,
-0.013956913,
0.0091922665,
0.024398165,
0.006763684,
-0.011967788,
-0.025244039,
-0.026473198,
-0.031403054,
0.03957102,
0.012615411,
-0.007520344,
0.010157091,
0.009734154,
-0.007176708,
-0.0077318125,
-0.0329362,
0.038328644,
-0.0062944884,
0.010150482,
0.016124465,
0.0010176916,
0.00055138726,
0.011604328,
-0.003704001,
0.01691747,
-0.0329362,
-0.015926212,
-0.005399052,
-0.021715159,
0.012258558,
0.019283272,
0.03777354,
0.016071597,
0.020234881,
0.0036379169,
0.027147254,
0.0009284784,
-0.027702358,
-0.021966279,
0.0077582463,
-0.011928138,
0.01597908,
0.0068264636,
-0.017208239,
-0.00034384264,
0.0007298137,
0.023710892,
-0.009496252,
0.044593394,
0.018741386,
0.019164322,
0.0046390877,
-0.0023360648,
-0.007031324,
0.0042921472,
0.021226138,
0.016335933,
0.0037998224,
0.036161095,
-0.013890829,
-0.014578101,
-0.015490059,
0.0026863092,
-0.002185724,
-0.0019726034,
-0.028601099,
0.007844156,
0.0016537488,
-0.00012545609,
-0.02224383,
0.017076071,
-0.0075930366,
-0.010599853,
0.0036940882,
0.005772426,
-0.011782754,
-0.027041519,
-0.0002699113,
0.012886355,
-0.0116505865,
0.0031555048,
0.012483243,
0.012364292,
0.009364084,
-0.0068528973,
-0.044064723,
0.006301097,
0.0058682477,
-0.002582227,
-0.015450409,
-0.0039055566,
-0.011928138,
0.03872515,
0.0043549268,
0.017644392,
-0.021649076,
-0.0025706624,
-0.00031617002,
0.019930895,
-0.028548231,
0.01605838,
0.0073551345,
-0.0009408691,
0.011901705,
0.0042326716,
0.02015558,
0.011868663,
-0.028627532,
0.016269848,
-0.0069057643,
-0.02741159,
0.007057757,
-0.012503068,
-0.006918981,
-0.014578101,
-0.0016289674,
-0.007143666,
0.0022964145,
0.038460813,
-0.007956497,
0.0038526896,
-0.0044970075,
0.021397958,
0.032301795,
0.01826558,
0.04842626,
0.020208446,
-0.015080339,
-0.0013076345,
-0.023776976,
0.03666333,
0.004526745,
-0.020697467,
-0.0070974077,
-0.018503483,
-0.0006505131,
-0.046998847,
0.000105630934,
-0.010533769,
0.00017553527,
-0.014525235,
-0.041236334,
-0.043879688,
-0.0035420954,
-0.024305647,
0.01474992,
-0.012027265,
0.011445726,
-0.012337858,
-0.0081944,
0.016520968,
-0.0030183806,
0.057678,
-0.03650473,
-0.00066207774,
0.00018431204,
-0.0011548157,
0.009033665,
-0.0010821234,
-0.0001280375,
-0.017089289,
-0.0076326868,
-0.01400978,
-0.059739817,
-0.011095482,
-0.00016861712,
0.029605573,
0.03227536,
0.022825368,
0.005481657,
0.03179956,
0.024358515,
-0.013249815,
0.013573627,
-0.011875271,
0.005009157,
-0.0056468667,
0.002834998,
0.00075418217,
-0.008524819,
0.019613693,
-0.012258558,
0.018741386,
0.019732643,
0.0040972,
-0.016891036,
0.0010160395,
-0.044434793,
0.01065272,
0.030451447,
-0.010196741,
0.027543757,
-0.04454053,
-0.017168589,
0.0327776,
0.01810698,
0.0033570605,
-0.008623945,
-0.0024632763,
-0.0332534,
0.02638068,
-0.015661877,
-0.014313766,
-0.00035623336,
-0.023393689,
0.012661669,
-0.009853105,
-0.0033223666,
-0.009899364,
0.0056171287,
-0.017842645,
-0.011320166,
0.009806846,
0.0069454145,
-0.0056766043,
0.016203765,
-0.01691747,
-0.005894681,
-0.023763759,
-0.007771463,
-0.01601873,
-0.021635858,
0.0071965335,
0.019270057,
-0.02757019,
0.022481732,
-0.023512641,
-0.00038989482,
0.0072361836,
-0.01356041,
-0.002834998,
-0.017419707,
0.021939844,
0.008974189,
-0.0002083707,
-0.018080547,
-0.012284991,
-0.0010903839,
0.018979287,
0.025376206,
-0.015093556,
-0.0008590903,
-0.020221664,
-0.016758868,
0.005554349,
-0.017168589,
-0.016758868,
0.0245832,
-0.0066876877,
0.0031026376,
-0.007837547,
-0.014155164,
-0.017234674,
0.0027457848,
-0.024424598,
-0.010064573,
-0.0035090535,
-0.008511602,
-0.010646111,
0.043958988,
0.0018123501,
0.012707928,
0.0009821715,
-0.00014197706,
0.0019246927,
0.0074542603,
-0.00946321,
0.0034594906,
0.014763136,
0.025719842,
-0.0054948735,
0.010163699,
0.0044705737,
0.0057327757,
-0.013771879,
0.00655552,
-0.021807676,
0.03988822,
-0.015423975,
-0.0028300416,
0.020049846,
-0.01601873,
0.03362347,
0.0009425212,
-0.013448067,
-0.018899987,
-0.01564866,
0.0034198402,
0.011075657,
0.0082472665,
-0.036319695,
0.011928138,
-0.033861373,
-0.006591866,
-0.027067952,
-0.019838378,
-0.029182637,
-0.024688933,
-0.0036280043,
-0.0163888,
0.007057757,
0.014630969,
0.012978872,
-0.009112965,
-0.005412269,
0.04216151,
-0.030319279,
0.044381928,
-0.018410966,
0.03986179,
-0.025984177,
0.010943489,
-0.028416064,
-0.014128732,
0.006763684,
-0.006152408,
-0.034601513,
-0.026777184,
-0.008650378,
0.020763552,
0.016904254,
-0.0008078753,
0.032671865,
0.0020766857,
0.010507335,
-0.0143401995,
0.0025524895,
0.01212639,
-0.025006136,
-0.0068925475,
0.03256613,
-0.00696524,
-0.0033967108,
-0.008815588,
0.0030299453,
0.012483243,
-0.015397541,
0.004285539,
-0.020578517,
0.036874797,
-0.0015273634,
0.00093343464,
-0.020578517,
-0.012496459,
-0.01437985,
0.03195816,
-0.00696524,
-0.0123709,
-0.024318865,
0.005042199,
-0.022468515,
0.020882502,
-0.031640958,
0.00050099834,
0.008861847,
-0.006373789,
-0.06899156,
-0.0016867907,
-0.016534183,
0.029473405,
0.01360006,
0.00017357341,
-0.030530747,
0.018463833,
-0.043800388,
-0.02101467,
0.002816825,
0.018569566,
-0.0032397616,
0.01642845,
-0.0011498593,
-0.0011506854,
0.013236599,
0.013864396,
-0.021649076,
-0.025574457,
0.0020783376,
-0.011895097,
0.015727961,
0.002646659,
-0.00946321,
-0.04776542,
0.021979494,
-0.027702358,
-0.024794668,
0.014208032,
0.0032926288,
0.03224893,
-0.011425901,
0.019930895,
0.017974813,
0.0065984745,
0.030504314,
-0.021160055,
0.0050785453,
0.026063478,
0.01065272,
-0.004573004,
-0.016005512,
0.007916847,
0.005894681,
0.010540377,
-0.03661046,
-0.023539074,
-0.0020799898,
-0.00649274,
0.016256632,
0.025627324,
-0.024768233,
0.009945623,
-0.011009573,
-0.008775937,
-0.033517737,
-0.0055774786,
-0.01892642,
0.02720012,
-0.0035949624,
0.006063195,
-0.020010196,
0.0095491195,
0.020221664,
-0.024398165,
0.006641429,
-0.011445726,
-0.020393481,
-0.014736703,
0.012364292,
0.0022088534,
-0.016613485,
-0.021675508,
-0.0067207296,
-0.0070445403,
0.0073551345,
0.000043522425,
0.01658705,
-0.010513944,
-0.01404943,
0.011538244,
-0.0018751298,
-0.02552159,
-0.026539281,
-0.022997186,
0.0004390447,
0.014234466,
0.17076072,
-0.018437399,
-0.011452335,
0.02622208,
-0.007381568,
0.00015870454,
-0.009899364,
0.009595377,
-0.0045333533,
0.031984594,
0.016520968,
0.00991258,
-0.008756112,
0.0049728113,
0.021292223,
-0.015701527,
-0.018913204,
0.0009416951,
-0.0076459036,
-0.0072361836,
0.010051357,
-0.0163095,
0.02257425,
-0.004235976,
0.0327776,
-0.0051941923,
-0.028653966,
0.0010622982,
0.033438437,
0.0006798378,
-0.020485999,
0.012939221,
0.006707513,
-0.006334139,
0.01356041,
0.014300549,
-0.011947963,
0.005071937,
-0.0049331607,
-0.0025574458,
0.008518211,
0.005425486,
0.0032348053,
0.009205483,
-0.008101882,
0.01597908,
-0.0046556084,
-0.009357476,
-0.022931103,
-0.009443385,
-0.024067745,
0.0037866058,
0.020340614,
0.037324168,
-0.0015447105,
0.002303023,
0.021807676,
-0.004130242,
0.02809886,
0.0043152766,
-0.034548648,
0.01642845,
-0.013586843,
0.03943885,
0.0008673508,
0.046628777,
0.008861847,
-0.017869078,
0.001519929,
-0.0033967108,
-0.0072229668,
-0.024001662,
-0.017115721,
-0.000051111743,
-0.002991947,
0.0012324641,
0.018001245,
0.010639503,
-0.007474086,
0.0070445403,
0.006985065,
-0.016600268,
-0.025376206,
0.0008830457,
-0.025429072,
-0.0454657,
0.013170515,
0.0039253817,
-0.01138625,
-0.0072031417,
0.0031158545,
0.022362782,
-0.017961595,
0.00032918027,
0.0031158545,
-0.025389422,
-0.00032381096,
-0.0014744963,
-0.017723694,
0.0031670695,
-0.015476842,
0.07269225,
0.0018090459,
-0.010229783,
0.011115307,
-0.014644185,
0.005627041,
0.026658233,
0.009813455,
0.015437191,
-0.002322848,
-0.02150369,
-0.0008813936,
-0.015001038,
-0.022812152,
0.017525442,
0.017670827,
-0.025230821,
-0.002972122,
-0.02109397,
-0.0016545749,
-0.016824953,
0.0115250265,
0.005620433,
-0.0027722183,
0.010018314,
0.0038659063,
0.012159432,
-0.0011316863,
-0.019732643,
0.002787087,
-0.013031739,
-0.0060268487,
0.0006649689,
0.009350867,
-0.0034528822,
0.0226932,
-0.015278591,
-0.02158299,
0.025019353,
0.0011795971,
-0.004698563,
0.016150897,
-0.010434642,
0.032989066,
-0.027173687,
0.015014255,
0.00076781196,
-0.01138625,
0.017181806,
-0.026182428,
-0.018807469,
0.015040688,
-0.007031324,
0.011439118,
-0.005719559,
-0.028204596,
-0.051756885,
0.0002168377,
0.003915469,
-0.023962012,
0.02380341,
0.0031522005,
0.0010837754,
-0.0059805904,
-0.00061871024,
-0.16621415,
0.00983328,
0.015780827,
-0.03843438,
-0.001230812,
0.009892755,
0.010540377,
-0.00043119726,
-0.0076789455,
0.016653135,
0.03806431,
0.006512565,
-0.031455923,
-0.0012531154,
-0.00016448688,
-0.0060598906,
-0.013097823,
0.012760795,
-0.00040249206,
0.011690237,
0.029711308,
-0.01687782,
0.011571285,
-0.012747578,
-0.0055708704,
0.03560599,
0.002732568,
0.0076459036,
0.01806733,
-0.028812567,
-0.021107187,
-0.0051115872,
0.02101467,
0.008756112,
0.023552291,
-0.0023641505,
0.00040868743,
-0.01564866,
-0.00016407386,
0.02154334,
0.022005929,
0.012978872,
0.010533769,
-0.00036449384,
-0.034310743,
-0.005835206,
0.007064366,
0.014260899,
0.025944527,
-0.001913128,
-0.000836787,
-0.0015628835,
0.009278175,
0.02425278,
0.040919133,
-0.00018007854,
0.020010196,
0.015450409,
-0.021279005,
0.0035652248,
0.012939221,
-0.018437399,
0.034019977,
0.011795971,
0.007804505,
-0.015331457,
0.019058587,
-0.0033901024,
-0.016745653,
-0.006016936,
-0.028891867,
0.0060004154,
0.012774012,
-0.0163095,
0.025600892,
0.014564885,
0.000631927,
0.0010969922,
-0.007156883,
0.017684042,
0.009073315,
-0.0021411174,
-0.045042764,
-0.014683835,
0.0034561863,
0.0068132468,
0.029922776,
0.014723486,
0.01921719,
-0.008504994,
0.008366218,
-0.04829409,
0.020644601,
-0.012318033,
0.027173687,
-0.0028449106,
0.012311425,
-0.015582576,
0.03354417,
0.010606461,
0.011049223,
-0.037139133,
-0.010401601,
0.0020386875,
0.013785095,
-0.014221248,
-0.030425014,
-0.0040872875,
0.015133206,
-0.014102298,
-0.0016099683,
-0.006320922,
-0.0010730368,
0.041897174,
-0.022309914,
0.013448067,
0.010586636,
-0.028072428,
0.0057526007,
-0.03240753,
0.07041897,
0.01937579,
-0.01613768,
0.022151314,
-0.006079716,
-0.025878442,
-0.12973586,
-0.05514038,
0.008914714,
0.0054750484,
-0.0024285822,
-0.0010193437,
-0.00011306537,
0.040496197,
-0.013864396,
0.02154334,
-0.013282858,
-0.030345712,
0.01397013,
-0.0011672063,
0.009271567,
0.016190547,
0.03449578,
-0.004543266,
0.0030448143,
0.023962012,
-0.0002583466,
-0.023605159,
-0.002630138,
-0.0027061345,
-0.013837962,
0.013348942,
-0.0328569,
0.0013654579,
0.005124804,
0.0054089646,
0.035262354,
-0.0015182769,
0.004110417,
-0.0020899023,
-0.0076062535,
-0.010018314,
-0.0040905913,
-0.030134244,
0.037218437,
0.008042407,
-0.0039650323,
0.0033967108,
0.0060598906,
0.0031736777,
-0.027517322,
0.00010051976,
-0.02605026,
-0.0024401469,
0.020684252,
-0.03560599,
-0.00913279,
-0.023036838,
-0.0034363612,
0.007982931,
0.021860544,
-0.02486075,
0.020671034,
0.004196326,
0.005256972,
-0.013890829,
0.028574664,
0.00680003,
-0.003499141,
0.029552706,
0.010573419,
-0.02511187,
-0.0035982667,
-0.04134207,
0.019203972,
-0.021939844,
0.013864396,
0.016719218,
0.0065687364,
-0.016230198,
-0.023909144,
-0.012397334,
-0.027067952,
-0.010659328,
0.0047117798,
-0.018318448,
-0.023565508,
-0.008564469,
0.021490473,
-0.012443593,
-0.014525235,
0.008419085,
-0.0017462663,
0.002407105,
-0.0004919118,
0.0003343431,
0.004318581,
0.010573419,
0.0017049639,
-0.021239355,
-0.018199498,
0.01781621,
-0.028495364,
-0.005653475,
0.038698714,
0.010104223,
0.0041401545,
-0.028706832,
-0.036266826,
0.01560901,
0.003310802,
-0.014313766,
0.00153645,
-0.016335933,
0.008267092,
-0.024688933,
0.0034462737,
0.002476493,
-0.03142949,
0.005514699,
0.0028102165,
-0.0059012896,
-0.0037667805,
-0.029896343,
0.0033488001,
-0.002615269,
0.019468307,
0.029182637,
0.016520968,
-0.0033603648,
0.023605159,
0.0039187735,
-0.01474992,
-0.0019246927,
-0.021847326,
0.023420123,
-0.010064573,
-0.007969715,
-0.0036412212,
-0.04126277,
0.0013621538,
0.012919396,
-0.031561654,
-0.0044705737,
0.017406492,
0.020234881,
0.024147045,
0.030557182,
-0.024424598,
-0.011478768,
-0.008346393,
-0.010685761,
0.004728301,
0.0036940882,
-0.032354664,
0.010262825,
0.0052999263,
-0.019071804,
0.022838585,
0.019270057,
0.010963314,
-0.054347374,
-0.025257254,
0.012179257,
0.0045366576,
0.009377301,
-0.00901384,
-0.033914242,
0.01356041,
0.01069237,
0.03642543,
-0.006780205,
0.013448067,
-0.009179049,
-0.014604535,
-0.012007439,
0.005104979,
-0.028574664,
-0.016983554,
0.018635651,
0.03166739,
-0.014710269,
0.0069916733,
0.0012068567,
-0.02109397,
0.01560901,
-0.010745237,
0.025230821,
0.010414817,
-0.0020370353,
-0.031403054,
-0.0033405395,
0.038037874,
-0.0027821308,
-0.02720012,
0.014697053,
0.010289258,
0.0136264935,
-0.0075798198,
0.0041665877,
0.011406076,
0.0015694919,
0.018120198,
0.03039858,
0.0063770935,
-0.0087098535,
0.010917055,
0.015833694,
0.0076855537,
0.009218699,
-0.00761947,
-0.034205012,
-0.015119989,
0.012423768,
-0.02838963,
-0.023195438,
-0.027094387,
0.012364292,
0.00659517,
0.013157298,
-0.0047382135,
0.013454676,
-0.023208655,
0.009687895,
-0.027094387,
-0.011749712,
-0.023354039,
0.005927723,
0.021649076,
-0.012132999,
-0.0116307605,
0.00995223,
0.0029638615,
0.0053230557,
0.032962635,
-0.041394934,
-0.0068859393,
-0.00036408083,
0.022970753,
-0.010137266,
-0.019613693,
-0.020208446,
0.00082109205,
-0.040284727,
0.00522393,
0.0152653735,
-0.0016372278,
0.0615373,
0.013943696,
0.0004237628,
-0.00071701,
-0.016534183,
0.018939637,
-0.00041323068,
0.015133206,
-0.021516908,
-0.007963106,
0.030292846,
-0.037218437,
0.021318655,
-0.04208221,
-0.03838151,
0.035949625,
0.009264958,
0.013745445,
0.013256424,
-0.019389007,
0.004272322,
-0.02417348,
0.00888828,
0.007474086,
-0.024186697,
-0.012007439,
0.04179144,
-0.0048769894,
-0.009383909,
-0.017908728,
-0.0071304496,
-0.005686517,
-0.034812983,
0.01802768,
0.020961802,
-0.026605366,
0.0031703736,
-0.011809187,
0.0065489113,
0.027226554,
-0.0036511337,
0.00028126946,
-0.03560599,
-0.018543134,
-0.011802579,
0.0123444665,
-0.018292015,
-0.010903838,
-0.03777354
] |
The aim of the study was to evaluate whether treatment with recombinant human growth hormone (rhGH) affects the quality of life of young adults who were diagnosed as idiopathic short stature (ISS) during childhood, and whether their quality of life and aspects of the personality are different from normal. Experiences and expectations concerning rhGH treatment of the subjects and their parents were also investigated. Eighty-nine subjects were included into the study: 24 subjects (16M, 8F) were treated with rhGH from childhood, whereas 65 subjects (40M, 25F) were never treated. At the time of the interview | [
-0.008792959,
-0.003927174,
0.022057356,
-0.027219716,
0.0062802196,
0.0079781925,
-0.0042498214,
-0.011263331,
-0.034024645,
-0.009509954,
0.008871177,
-0.008805996,
0.014079164,
-0.00009823027,
-0.009979259,
0.003330765,
0.032773163,
-0.024781935,
-0.0050580697,
-0.012547403,
-0.0006420359,
0.010950461,
-0.0047940854,
-0.005804396,
-0.010937424,
0.008414907,
0.040699214,
-0.025316423,
0.016660344,
0.0030749284,
-0.00013005709,
-0.018459348,
0.002675693,
-0.008988503,
-0.0017240457,
-0.007547996,
-0.0038489567,
-0.0013647338,
0.014444179,
-0.0152785,
0.024899261,
-0.0036305992,
-0.002626807,
-0.0011577831,
0.007795685,
0.009281819,
0.016373547,
-0.036423318,
-0.011269849,
0.012527849,
0.0032166978,
0.028366908,
-0.032512438,
0.022461481,
-0.0037348892,
-0.0073198616,
0.007404597,
0.010631072,
0.0105333,
-0.012788573,
-0.0101943575,
-0.013238325,
-0.03334676,
0.011693528,
-0.010370347,
-0.0023888953,
-0.01946314,
0.0016311624,
0.03170419,
0.0015944979,
0.038065888,
0.032799236,
-0.024208339,
0.008310618,
0.030270202,
-0.008343209,
-0.00170938,
-0.018772218,
0.0152393915,
-0.0073524523,
0.018003078,
-0.01956743,
-0.012990636,
0.02545982,
0.0029070866,
0.010715808,
-0.0014804306,
0.015408862,
-0.003773998,
-0.019215452,
0.0013134035,
-0.0017517478,
0.0077565764,
0.017390374,
0.009190565,
0.004578987,
0.007965157,
0.02179663,
-0.01192818,
-0.011393693,
-0.025525002,
0.0048560076,
0.011713082,
-0.0039890963,
-0.0024442992,
0.008062929,
-0.01440507,
-0.0033095812,
0.011621828,
-0.0076979133,
-0.020949274,
0.034259297,
-0.00265125,
-0.009607726,
0.019241523,
0.0045952825,
0.012912418,
-0.0023954134,
0.007926048,
0.0008832068,
0.013688076,
-0.011276367,
0.02044086,
-0.0067397477,
-0.0037414073,
0.013049299,
-0.019684756,
-0.017833607,
-0.008636524,
-0.009464326,
-0.015004738,
-0.001935885,
0.016960178,
-0.0018250768,
-0.0110351965,
-0.0025583666,
-0.012547403,
-0.0067723384,
-0.0258118,
-0.016256219,
0.0002572625,
0.026724339,
-0.018628819,
0.00544264,
-0.038874134,
0.00962728,
0.03428537,
0.015513153,
0.0026919881,
-0.005299241,
0.00540679,
-0.007300307,
0.010050959,
0.02849727,
0.010435528,
0.042211417,
0.0016865665,
0.02899265,
-0.04234178,
0.015878169,
-0.0070265457,
-0.0056414427,
0.0023204547,
-0.005908686,
-0.013205734,
0.0067267115,
-0.000315722,
0.0011121562,
0.012606066,
-0.0072090533,
-0.0074241515,
0.025316423,
-0.040073473,
0.0021998694,
-0.005204728,
0.009340482,
0.0144181065,
0.01287331,
-0.00056096667,
-0.0053807176,
-0.01220846,
0.032069206,
0.02560322,
0.03446788,
-0.015578334,
0.0026382136,
0.0075284415,
0.005657738,
0.013740221,
-0.012834201,
0.0118955895,
0.023204548,
0.0031857367,
-0.01838113,
-0.6603649,
-0.020180134,
-0.0006839964,
-0.005758769,
0.042550363,
0.027428297,
0.008343209,
0.025212131,
-0.0015684253,
0.024794972,
0.017220903,
0.038222324,
-0.00033588745,
-0.03034842,
-0.0062150382,
-0.029201228,
-0.015043847,
-0.019541359,
0.01600853,
-0.0014690239,
-0.009770679,
0.008238918,
0.017598955,
0.019476177,
0.0017175276,
0.019176342,
0.020479968,
-0.014574542,
0.006149857,
0.029592317,
0.0008343208,
0.042550363,
0.007052618,
0.021561978,
0.050841425,
-0.0189808,
0.0034839413,
0.018003078,
-0.0054491577,
0.03511969,
-0.017246975,
0.002856571,
0.034311444,
0.009959704,
-0.02235719,
0.015786914,
0.004018428,
0.017585918,
0.02828869,
-0.004732163,
0.010311684,
-0.0037348892,
-0.010402937,
-0.009666389,
0.022696134,
-0.020975348,
0.02162716,
0.00376748,
0.0074697784,
-0.00092964846,
0.002916864,
0.032408148,
-0.023360983,
0.0074502244,
0.013440386,
0.02483408,
0.0030455969,
0.022318082,
-0.0052308002,
-0.019202415,
0.015004738,
0.0447926,
-0.026802557,
0.007574069,
0.011947735,
0.024612464,
0.016790707,
0.01590424,
-0.035067547,
0.014209527,
-0.00010337349,
0.010122658,
0.0017175276,
0.0043736664,
0.020088881,
-0.009131902,
-0.03201706,
-0.0009948298,
-0.024117086,
-0.000003723737,
-0.0048397128,
-0.00014492658,
-0.01022043,
-0.027819384,
-0.0070591364,
0.013961838,
0.00062655535,
0.020975348,
0.020623367,
-0.00882555,
-0.0021721672,
0.009979259,
0.0011643012,
0.028966576,
-0.007867385,
0.01332306,
-0.027376153,
0.022057356,
0.022800423,
-0.031026306,
0.008766887,
0.020349607,
-0.007776131,
0.01119815,
-0.0036925215,
-0.03034842,
0.011380658,
0.0029983404,
0.0023742293,
-0.03126096,
0.023765108,
-0.01656909,
0.016934106,
0.0119151445,
0.011621828,
0.012247569,
0.000067880224,
-0.004715868,
-0.009562098,
0.0021297995,
0.014796158,
-0.007984711,
0.02064944,
-0.015656551,
0.029644461,
0.006156375,
0.025629293,
-0.015056883,
0.009223156,
-0.015135101,
0.0007398079,
-0.006948328,
0.017181795,
0.005703365,
-0.017625026,
-0.023478309,
-0.009451291,
-0.0102139115,
0.001579832,
-0.004328039,
-0.0102334665,
-0.009894524,
-0.02270917,
0.018667929,
-0.022018248,
-0.026502723,
-0.019971555,
-0.028575487,
0.01022043,
-0.009555581,
-0.0046441685,
0.033372834,
-0.011159041,
-0.022278974,
-0.01573477,
-0.018563638,
-0.010513746,
0.011576201,
-0.0006844038,
-0.023608672,
0.0038880655,
-0.018511493,
-0.021131782,
-0.0073654884,
-0.010187839,
0.015891204,
0.010611518,
-0.014978666,
-0.014000946,
-0.007137354,
-0.024038868,
-0.001398954,
-0.024364775,
0.0011170447,
0.028262617,
0.010846171,
0.011009124,
0.020010663,
0.0027604287,
0.041246735,
-0.01563048,
0.020479968,
-0.0258118,
0.040959936,
0.0022471258,
-0.019489212,
0.019059015,
-0.008414907,
-0.008923322,
0.024351738,
0.011400212,
-0.007404597,
0.02410405,
0.0016613087,
0.013453423,
-0.00040595737,
0.010474637,
-0.012338823,
0.016842851,
0.00031185185,
-0.0030863353,
-0.0005047478,
0.002532294,
-0.009236192,
-0.01008355,
-0.0034546095,
-0.018029151,
0.0058891317,
-0.017442519,
0.0061368207,
0.009790233,
-0.0064203595,
-0.009764161,
-0.0034024646,
0.001405472,
0.02899265,
0.012091134,
-0.016764633,
0.0033829103,
-0.006547463,
-0.014313816,
0.010455083,
0.01942403,
0.018355059,
0.0040379823,
0.014522397,
0.0012702208,
-0.033868212,
0.024156194,
0.014079164,
0.0039108787,
-0.013635931,
0.016451763,
-0.00962728,
-0.0040053916,
0.0046311324,
0.01842024,
-0.0054719714,
-0.039082717,
0.012925454,
0.0016083489,
0.022174682,
0.013401278,
-0.028575487,
0.0030260424,
0.015461007,
-0.0020271388,
0.010637591,
0.0082258815,
0.034885038,
0.0063942866,
0.0110351965,
0.018824363,
-0.006009717,
0.011315476,
0.023947615,
0.002089061,
0.007339416,
-0.0063682143,
-0.008812513,
0.0042074537,
0.0088190315,
0.0054230853,
-0.018993834,
0.0016384952,
0.011243776,
0.0040640547,
-0.0058369865,
0.013505568,
0.021353398,
-0.002382377,
-0.002110245,
0.0085126795,
0.01199988,
0.00599994,
-0.00017802646,
-0.009444772,
0.0094904,
-0.021913957,
0.016894996,
-0.0008742444,
0.0008102852,
0.02033657,
0.0052862046,
0.01667338,
-0.0068244836,
0.011823891,
0.0061596343,
0.00070762465,
-0.012808128,
0.009953187,
-0.0127364285,
-0.0045138057,
-0.00058826135,
0.017260011,
0.00050026656,
-0.046226587,
-0.02943588,
-0.012195424,
-0.01109386,
0.008017302,
-0.007854348,
-0.008962431,
0.031756338,
-0.0030781876,
-0.010650626,
-0.029905187,
-0.007750058,
0.012501776,
-0.03191277,
-0.006094453,
-0.034885038,
-0.011778263,
-0.023634745,
0.07368096,
0.026268069,
0.023869397,
0.020101918,
0.0071047633,
0.0067397477,
0.009347,
-0.023413127,
0.009796752,
-0.012006398,
0.0105333,
0.005726178,
0.008721259,
-0.007502369,
-0.012006398,
0.014535433,
0.020206207,
-0.01430078,
-0.028757995,
0.025485894,
0.0016221999,
0.008682151,
0.025642328,
0.04591372,
0.02179663,
-0.015304573,
-0.0076718405,
0.02012799,
-0.008714742,
-0.021353398,
-0.009542544,
-0.0057424735,
-0.0030749284,
0.014313816,
-0.022826497,
-0.020049771,
0.0026805815,
-0.0037251122,
0.008199809,
0.014874375,
0.028653705,
-0.002009214,
0.014053091,
0.018081296,
-0.0012286678,
0.005797878,
-0.00054181967,
0.012025952,
-0.013218771,
-0.01486134,
0.015995495,
-0.034754675,
0.0034448325,
-0.002361193,
0.01663427,
-0.0041324953,
-0.0051330286,
-0.007443706,
-0.0052503548,
-0.0163214,
-0.011361103,
-0.039160933,
0.008884213,
-0.011921662,
-0.015265464,
-0.013094926,
-0.0019766234,
-0.003376392,
-0.0020841726,
0.009646835,
-0.0064073233,
-0.023087222,
0.0021575014,
0.0010600111,
0.016451763,
0.009672907,
0.0061465977,
0.0075284415,
-0.009894524,
-0.011028678,
-0.017142685,
-0.021718415,
-0.0038522156,
-0.012566958,
0.006198743,
0.018120404,
-0.002201499,
-0.012938491,
-0.026098598,
0.004416034,
0.011889071,
-0.0025762913,
0.0094187,
-0.01698625,
-0.01450936,
-0.0147049045,
0.03384214,
-0.010767953,
-0.021275181,
-0.012175869,
-0.018446311,
0.00025359605,
-0.02148376,
-0.008910285,
-0.0058826134,
0.024925334,
-0.020688549,
0.00069458835,
-0.024495138,
-0.025876982,
0.02427352,
-0.027402224,
-0.0013019968,
0.0011936328,
0.0201671,
-0.0067853746,
-0.010448565,
0.0188374,
0.024990516,
-0.0013125887,
-0.018746145,
-0.021275181,
0.038483046,
-0.0021509833,
-0.041038156,
-0.010474637,
0.008851622,
-0.0031824776,
-0.04140317,
0.00007969434,
-0.020088881,
0.018707037,
0.019945482,
-0.0036892623,
-0.032955673,
-0.021249108,
-0.02416923,
0.009685943,
0.011230741,
-0.04262858,
-0.02766295,
-0.0068179653,
-0.003578454,
-0.007782649,
0.017611992,
-0.031547755,
-0.015187246,
0.012332304,
0.0019505508,
-0.003868511,
-0.002762058,
0.021470726,
-0.03637117,
0.015004738,
-0.0076262136,
-0.044922963,
0.024025831,
-0.0051265103,
0.032173496,
0.0037348892,
0.013961838,
-0.0069613643,
-0.0101943575,
0.034624312,
0.022070393,
-0.0037316303,
0.011980325,
0.006720193,
-0.02808011,
0.03128703,
0.014079164,
-0.002110245,
-0.0022683097,
-0.016712489,
0.0033160993,
0.00903413,
-0.008089001,
-0.0062639243,
-0.011139487,
-0.045548704,
-0.010761435,
0.021144819,
-0.006355178,
0.003972801,
-0.03665797,
-0.0113219945,
0.025433749,
-0.008036856,
0.003422019,
-0.02487319,
0.01088528,
-0.036058303,
-0.005458935,
-0.0006322587,
-0.018498456,
-0.0023074185,
0.003247659,
-0.009073239,
0.0016189408,
0.026111634,
0.00049374846,
0.010005332,
0.017638063,
-0.0326428,
-0.0067136753,
-0.015356718,
-0.019189378,
-0.0102139115,
-0.011602274,
-0.022226827,
0.005504562,
-0.021783596,
0.00603579,
-0.017950933,
-0.009725052,
0.0071243173,
-0.015812987,
0.0051362873,
-0.02797582,
0.003275361,
0.011563165,
-0.010950461,
0.01694714,
-0.008714742,
0.028262617,
0.027636876,
-0.010259539,
-0.034650385,
-0.0015431676,
0.01001185,
0.0023563046,
0.017364303,
0.016686417,
0.022031285,
-0.022174682,
0.020597296,
0.008349726,
-0.030922014,
-0.0479213,
-0.0077565764,
-0.0022731982,
-0.0029429363,
-0.017051432,
-0.00861697,
-0.041585676,
0.03676226,
-0.005149324,
0.006485541,
-0.0064659864,
-0.008010783,
-0.0056740334,
0.0071764626,
-0.0067788567,
0.0052014687,
0.012410522,
-0.011146004,
-0.024664609,
-0.029070865,
-0.033711776,
0.016191037,
0.0037381484,
0.008447498,
-0.011132969,
0.013029745,
0.0070135095,
-0.011673973,
0.014626686,
-0.016086748,
-0.01213676,
0.025968235,
-0.009496917,
-0.022591844,
0.018798292,
-0.013531641,
0.00784783,
0.003470905,
-0.010689735,
-0.008049892,
-0.012671247,
-0.007091727,
0.020219244,
0.03086987,
-0.028419053,
0.0065376856,
-0.025863945,
-0.010728844,
-0.018720074,
-0.029488027,
0.0129841175,
-0.032877456,
-0.0031270734,
-0.0076262136,
-0.00017660062,
0.028001891,
0.011517538,
-0.0003271287,
0.011921662,
0.04189855,
-0.031652045,
0.003467646,
0.0077109495,
-0.0065833125,
-0.00303419,
0.01688196,
-0.0048918575,
-0.01740341,
0.018537566,
-0.007143872,
-0.037127275,
-0.026072524,
0.022683097,
-0.0045007695,
0.0051982095,
-0.014183454,
0.0065604993,
0.0015081327,
-0.0044812155,
-0.0076653226,
-0.028653705,
-0.018811326,
0.018876508,
0.0040282053,
-0.00275554,
-0.0072742347,
0.025342494,
-0.006202002,
0.03519791,
0.015434935,
-0.013218771,
-0.020949274,
-0.0034546095,
0.013766293,
-0.010396419,
0.021262145,
-0.027845457,
-0.014444179,
-0.021327326,
0.02797582,
-0.012599548,
-0.019593503,
-0.02797582,
0.014235599,
0.007287271,
0.021431616,
-0.012462667,
0.0060651214,
0.010572409,
0.0059673493,
-0.024677645,
-0.00610423,
0.002159131,
0.039708458,
0.026007345,
-0.028940503,
-0.043958277,
-0.028236546,
-0.045366194,
-0.0030455969,
-0.0022666801,
0.007808721,
-0.0014119903,
0.025094805,
-0.00081313687,
0.021157855,
0.00017823016,
0.0048820805,
-0.0071699447,
-0.020701585,
0.005654479,
0.007632732,
0.013857547,
-0.0020499523,
-0.026268069,
-0.00021245034,
0.021340363,
-0.005595816,
0.0005654479,
0.016034603,
0.0014820601,
0.03076558,
-0.020831948,
0.021196963,
0.0058826134,
-0.006472504,
0.0029005685,
-0.018746145,
-0.016191037,
0.008603933,
-0.009438254,
-0.019828156,
-0.009040648,
-0.013036262,
-0.010846171,
0.006612644,
-0.009783715,
-0.011934699,
0.004650687,
0.010350793,
0.032903526,
0.016295329,
-0.0126973195,
-0.012390967,
0.0071177995,
-0.009399146,
-0.013336097,
0.04307181,
0.026698265,
-0.009855415,
0.014548469,
-0.014744014,
0.0032558066,
0.012788573,
0.0038359202,
0.000119566976,
0.01161531,
-0.016556054,
-0.0012848866,
0.0035914904,
0.008506161,
-0.0023628226,
0.0017468592,
-0.009581653,
-0.0007996932,
-0.015421899,
0.0017142686,
-0.019124197,
-0.017520737,
-0.030922014,
-0.014978666,
-0.01636051,
-0.016934106,
-0.004210713,
-0.0013500679,
-0.008414907,
-0.004530101,
0.013831475,
0.19856836,
0.0029608612,
0.0038000706,
0.015004738,
0.0118955895,
-0.012606066,
0.05318795,
-0.011726119,
-0.0029413067,
0.019593503,
0.01109386,
0.008408389,
-0.013101444,
-0.00069703266,
0.016060676,
-0.026111634,
-0.022383263,
-0.00014930595,
0.010259539,
-0.016516944,
-0.016543018,
0.0061237845,
-0.015265464,
-0.012651693,
0.016543018,
0.0022503848,
-0.030061621,
0.01806826,
0.004416034,
0.033294614,
-0.0012531107,
-0.01252133,
0.013049299,
0.004187899,
-0.0027750945,
0.0013231806,
0.013088408,
-0.016086748,
-0.0068244836,
0.011993362,
0.0039923554,
0.016034603,
0.0028696074,
-0.0065344265,
0.018485421,
0.01733823,
-0.011185113,
0.0025714028,
-0.012475704,
0.01091787,
-0.038665555,
0.00065670174,
0.027923675,
0.045679066,
0.012664729,
0.002113504,
0.0046930546,
-0.0038326613,
-0.021822704,
-0.0017452297,
-0.013453423,
0.01573477,
-0.01719483,
0.022109501,
-0.018159514,
0.04168997,
-0.03436359,
-0.0054752305,
-0.024221376,
0.008877695,
-0.0033633558,
0.00061677815,
-0.020910166,
0.0020483227,
-0.02633325,
-0.031652045,
0.026750412,
0.016334437,
0.013049299,
0.014496325,
-0.005869577,
0.0032802497,
-0.03478075,
0.025120879,
-0.043228246,
-0.017977007,
0.016269255,
0.027037209,
-0.0246255,
-0.0118564805,
0.016934106,
-0.00033649852,
-0.005556707,
-0.008395353,
0.011980325,
-0.011524056,
0.0071634264,
0.017833607,
0.0031075191,
0.000751622,
-0.0030635218,
0.06825787,
-0.013264397,
0.019515285,
-0.005074365,
-0.010559373,
-0.006306292,
0.025785727,
-0.008317135,
-0.0071894987,
0.006948328,
-0.034546096,
0.01081358,
-0.01563048,
0.016269255,
-0.002278087,
0.009672907,
-0.035223983,
0.023947615,
-0.021496797,
-0.008284545,
0.00089868734,
0.004174863,
0.040412415,
-0.022826497,
-0.00016539758,
-0.005941277,
-0.013303506,
-0.004781049,
-0.022878641,
-0.0052405777,
-0.021327326,
-0.005168878,
-0.0018185587,
0.006606126,
-0.012892864,
-0.0045366194,
0.014000946,
0.000060598253,
0.016412655,
0.003024413,
-0.0034904594,
0.002235719,
-0.0064073233,
0.010611518,
-0.018342022,
0.023765108,
0.00596409,
-0.00002369188,
0.004924448,
-0.02396065,
0.0023155662,
-0.0003028894,
-0.021301253,
0.018342022,
0.00401191,
-0.018720074,
-0.029331591,
0.0051753963,
0.013479495,
-0.01486134,
0.012012916,
0.026320215,
0.013622895,
-0.01419649,
0.010311684,
-0.16425692,
0.027636876,
0.02693292,
-0.031026306,
0.030478783,
-0.0127559835,
0.027923675,
-0.022161646,
-0.004520324,
0.0027848717,
0.016425692,
0.004530101,
-0.029983405,
-0.0028125737,
-0.005064588,
0.005103697,
-0.019228488,
0.019932445,
0.039682385,
-0.00013056632,
-0.011765227,
-0.0032802497,
0.018628819,
0.022513626,
0.003953247,
-0.011132969,
0.0028353871,
0.020884093,
-0.011374139,
-0.011387176,
-0.013583786,
0.0025518485,
0.029279446,
0.008434462,
0.006948328,
-0.012808128,
0.018928653,
0.013453423,
-0.00983586,
-0.0038065887,
0.033581413,
0.0176511,
0.0079586385,
0.013283952,
0.0016238295,
-0.005618629,
0.02204432,
0.0017827089,
0.005419826,
-0.011374139,
0.0035067548,
-0.032773163,
0.015682625,
0.0036501535,
0.0006607756,
-0.009190565,
0.0068179653,
0.0052470956,
-0.019306704,
-0.0007565106,
-0.017416447,
-0.013818438,
0.027193643,
-0.020479968,
0.013662003,
-0.015200282,
-0.018342022,
-0.02808011,
-0.019111162,
0.0067136753,
-0.020701585,
-0.0032492885,
-0.0016075341,
0.020427823,
0.025003552,
0.029044794,
0.011224222,
-0.028940503,
-0.0055436706,
0.020714622,
0.0064920587,
0.0067397477,
-0.026985064,
-0.0050711064,
-0.016125858,
0.038665555,
0.027037209,
0.021288216,
0.0073328977,
-0.012169351,
0.0015407233,
-0.028314762,
-0.00011019716,
0.00962728,
-0.008499643,
0.023478309,
-0.013831475,
0.016934106,
0.000133418,
-0.022513626,
0.01694714,
-0.00005494581,
-0.0070721726,
-0.0020075846,
0.009164493,
-0.025068734,
-0.010318202,
0.007385043,
0.0350154,
-0.021236071,
-0.003963024,
0.021444652,
-0.017286085,
0.014079164,
-0.011602274,
0.055482335,
-0.010852689,
-0.0063225874,
0.011550128,
-0.020962311,
0.057150975,
0.009112348,
-0.031443466,
0.004807122,
0.00043752955,
-0.007821757,
-0.13255271,
-0.0030602627,
0.021131782,
-0.005214505,
0.021496797,
0.02410405,
0.00408035,
-0.00854527,
-0.020988382,
0.0015879797,
-0.033581413,
-0.032694947,
0.00007353267,
-0.010259539,
0.0222529,
-0.019332778,
0.013766293,
-0.034207154,
-0.01001185,
0.033789992,
0.0054263445,
-0.00021326511,
-0.01252133,
-0.0059217224,
-0.0075284415,
-0.01956743,
-0.030557,
0.003247659,
0.0006746266,
0.025238205,
0.0077239857,
-0.010539819,
0.025694475,
0.0062215566,
-0.0051428056,
-0.008141146,
-0.02012799,
-0.0013973244,
0.029488027,
-0.009431736,
0.013766293,
0.024469065,
0.014822231,
-0.005986904,
0.024573356,
-0.00027803905,
-0.014274708,
-0.0013508827,
0.0066289394,
-0.0014185084,
-0.045600846,
0.004468179,
-0.038065888,
-0.0027604287,
0.01604764,
-0.0021917217,
0.03126096,
0.0056349244,
0.004957039,
0.0016816779,
-0.020701585,
0.020427823,
-0.008630006,
-0.005263391,
0.004468179,
0.0069613643,
-0.025251241,
-0.022591844,
0.015187246,
-0.01440507,
-0.024599427,
0.007945602,
-0.010956978,
-0.014079164,
-0.030009476,
-0.0062182974,
-0.032121353,
-0.037987668,
0.013166625,
-0.02441692,
-0.0024785195,
-0.010878761,
0.030478783,
-0.0028207214,
0.012201942,
-0.00072432734,
0.013062336,
-0.01168701,
0.0026528796,
0.0037479256,
-0.019919408,
0.019032944,
0.0024605945,
-0.0074176337,
0.0041455314,
0.008955913,
-0.006198743,
-0.0016996027,
0.012782056,
0.00038008855,
-0.038222324,
-0.029149083,
-0.0379616,
0.024130123,
0.023491345,
-0.0027408742,
-0.015200282,
-0.027089354,
0.01929367,
-0.007391561,
0.015304573,
-0.01088528,
0.006531168,
0.009953187,
-0.012625621,
0.0045463964,
-0.021900922,
-0.024651572,
0.01029213,
-0.00060007547,
0.027271861,
0.010259539,
-0.007345934,
-0.0040542777,
0.0054752305,
0.026724339,
0.005951054,
0.022461481,
-0.027324006,
0.026085561,
0.0009850526,
-0.017533774,
0.016725525,
-0.04513154,
-0.012149797,
-0.007313343,
-0.00093046325,
-0.009405663,
-0.0015586482,
0.031417392,
0.02298293,
0.027037209,
-0.028523343,
-0.023712961,
0.018172551,
-0.00146495,
0.02458639,
0.02695899,
-0.022995967,
0.0132709155,
0.013531641,
-0.006143339,
0.032564584,
0.013844511,
-0.015187246,
-0.035849724,
-0.008975467,
0.0055404115,
-0.019280633,
0.011634865,
-0.021262145,
0.011784782,
0.032564584,
-0.05141502,
0.004370407,
-0.0028027964,
0.0077174674,
-0.016282292,
-0.013909692,
-0.0009654982,
0.013635931,
-0.01329047,
-0.04296752,
0.0099466685,
0.0030602627,
0.018667929,
0.019971555,
0.021966103,
-0.0068570743,
0.021131782,
-0.0069613643,
0.0075088874,
0.008949394,
0.0035621587,
-0.02724579,
-0.0023106777,
0.008154183,
0.015122064,
-0.016060676,
0.0210666,
0.0054328623,
-0.009575135,
0.0025534779,
0.025303386,
0.009164493,
0.0019652166,
0.023152402,
0.038900208,
0.0012539255,
-0.026255034,
0.012462667,
0.019971555,
-0.0034643868,
0.0007805462,
-0.008154183,
-0.029409809,
-0.025733583,
0.0030390788,
-0.016764633,
-0.030165913,
-0.007932566,
-0.013805402,
0.03076558,
-0.004898376,
-0.010735363,
0.011654419,
-0.014809194,
0.005491526,
-0.0022650505,
-0.011765227,
-0.00035360863,
0.038274467,
0.007645768,
0.010415974,
0.0031857367,
-0.012377932,
0.022070393,
-0.0029657497,
0.0022471258,
0.0056153703,
0.0024394107,
-0.009562098,
0.00036073785,
-0.0163214,
-0.023608672,
0.00223246,
0.019828156,
-0.026281105,
-0.009040648,
0.021561978,
-0.02075373,
0.06945721,
-0.016204074,
0.0053807176,
0.0020678772,
-0.013753257,
0.013453423,
-0.010142213,
0.021288216,
-0.03303389,
-0.030791653,
0.020818911,
-0.03313818,
0.030948088,
-0.024403883,
-0.027402224,
-0.0028484233,
0.0022031283,
0.006544204,
0.018511493,
-0.007091727,
-0.00028313132,
-0.022005212,
0.014848303,
-0.003721853,
-0.016178003,
0.0007222904,
0.014248635,
-0.018785255,
0.0039467285,
-0.022213792,
0.0006326661,
0.024664609,
-0.045809425,
-0.0023253434,
0.007196017,
-0.02414316,
-0.010155248,
-0.007795685,
-0.012254087,
-0.013388242,
0.010135694,
0.0051428056,
-0.017299121,
0.0017207867,
-0.01796397,
-0.027689021,
-0.004670241,
0.0057424735,
0.002033657
] |
Homicide is one of the leading causes of death among African-American and Hispanic men. We investigated how neighborhood characteristics associated with social disadvantage explain racial/ethnic homicide gaps in 10 U.S. cities. The test hypotheses were that (1) higher concentrations of African-Americans and Hispanics would be associated with higher homicide rates and (2) the relationship between racial/ethnic concentration and homicide would be attenuated after adjusting for neighborhood characteristics (e.g., unemployment, median household income, low educational attainment, and female headship). The test hypotheses were examined using separate Poisson regression models, which adjusted for spatial autocorrelation. Homicide rates | [
0.0037883332,
0.0060524046,
0.021377934,
-0.034031224,
-0.018099815,
0.016122738,
0.008144279,
0.03188833,
-0.02409482,
-0.039592545,
-0.01619927,
0.010159621,
-0.0038297882,
0.012965794,
-0.008424896,
0.010912186,
0.054133624,
-0.017933995,
0.01641611,
-0.03267916,
-0.024247885,
0.0366078,
0.006549862,
-0.0057048216,
-0.016518153,
0.03515369,
0.024515746,
-0.01595692,
-0.009132816,
-0.020561593,
-0.009655786,
-0.013482384,
-0.022525914,
-0.01986005,
-0.03816395,
0.013061459,
0.012819108,
-0.03472001,
0.0038839981,
-0.012978549,
-0.006291567,
-0.009190216,
-0.008718269,
-0.039618056,
0.022666223,
0.014273215,
-0.020255465,
-0.008488673,
-0.04086808,
0.02311266,
0.017985016,
0.016492642,
0.0005971089,
0.00032067698,
0.03849559,
0.012512979,
-0.0018989498,
0.00923486,
0.00023497711,
-0.012589511,
0.0026865916,
-0.014018108,
-0.04362323,
0.022002947,
-0.028061727,
-0.0046939617,
-0.013086969,
0.026811706,
-0.0010897836,
0.006709304,
0.022959596,
0.016888058,
-0.008903221,
-0.0047896267,
0.022360096,
-0.0021987,
-0.016888058,
-0.006521163,
0.002297554,
0.01485996,
0.019770762,
-0.015089557,
-0.025548927,
0.01715592,
0.009611142,
-0.012500225,
-0.013227278,
0.021148339,
0.01406913,
0.009898136,
-0.006020516,
-0.0058196196,
0.020752924,
-0.0035874369,
-0.0053253504,
-0.002799795,
-0.01521711,
0.008762912,
0.00964303,
-0.008150657,
-0.023584606,
-0.015510483,
-0.011454287,
-0.00857796,
-0.0012284978,
-0.01464312,
-0.025446884,
-0.009496344,
-0.0036926682,
-0.007194007,
0.008839444,
0.004515387,
0.016530909,
-0.028265813,
0.0077361083,
-0.031735264,
-0.015115067,
-0.016263047,
-0.013750247,
-0.019681476,
0.007315182,
0.012385426,
0.017041123,
-0.027526004,
0.0017411027,
0.005813242,
-0.0057239546,
-0.014336992,
-0.012468336,
-0.003622514,
-0.011696639,
0.0014748351,
0.0009175866,
0.0008785234,
-0.03211792,
0.022143254,
-0.03357203,
-0.02625047,
-0.02739845,
-0.031352602,
0.007965704,
0.007436358,
-0.002956048,
-0.00039601317,
0.011907102,
0.04433753,
0.034439392,
0.011186426,
0.003297253,
-0.00003599893,
0.013086969,
-0.010714478,
0.014311481,
-0.005127643,
-0.0008777262,
0.0032478261,
-0.012659666,
0.0144773,
-0.020089647,
-0.03005156,
0.0044133444,
-0.029464815,
-0.0007629282,
0.022066722,
0.02196468,
0.01813808,
-0.0011352245,
0.016071716,
0.000842649,
-0.0028013894,
-0.0012691554,
0.0021843505,
-0.01912024,
0.016224781,
0.0016550042,
0.002734424,
0.017130408,
0.006804969,
-0.03775578,
-0.012838241,
0.007219517,
0.0039605303,
0.023367766,
0.013533406,
0.0019738874,
-0.00942619,
0.02701579,
-0.012940283,
-0.005966306,
-0.011224691,
0.0009183838,
0.014566588,
-0.002584549,
-0.021237627,
-0.65674645,
-0.0074427356,
0.000098056604,
-0.009636653,
-0.005258385,
0.0076595764,
0.02196468,
0.01849523,
0.002680214,
0.028367857,
0.0019962094,
0.023967266,
0.009349657,
-0.026913747,
-0.02622496,
-0.018227369,
-0.013992598,
-0.0023342255,
0.007194007,
-0.003970097,
0.0030772237,
-8.8751693e-7,
-0.018278388,
0.0035874369,
0.0039541526,
0.037296586,
0.018750336,
-0.0057239546,
0.0006668646,
0.012697931,
-0.007525645,
0.02280653,
0.00045161843,
0.010478504,
0.047347788,
-0.01330381,
0.009611142,
0.036097586,
0.009936403,
0.028725006,
0.0002628794,
-0.01368647,
0.005350861,
0.01873758,
0.01849523,
-0.006291567,
0.024566768,
-0.006613639,
0.022053966,
-0.023826959,
0.013558917,
0.0021843505,
-0.010306307,
0.012506602,
0.0064510084,
-0.0063521545,
0.00860347,
-0.01718143,
-0.0003214742,
-0.008782045,
-0.010414728,
-0.012653288,
-0.0057654097,
-0.00277269,
-0.02538311,
0.038010884,
-0.0008490267,
0.013252789,
-0.0061640134,
0.002378869,
-0.0233295,
0.038061906,
-0.017525824,
-0.013444119,
0.026811706,
0.0208167,
0.026173938,
0.013558917,
-0.024528502,
-0.011498931,
-0.008456784,
-0.0034630722,
-0.021862637,
-0.020089647,
-0.0014716462,
-0.020803945,
-0.012455581,
0.009592009,
-0.006524352,
0.019694231,
0.012391804,
-0.010663456,
-0.009936403,
-0.013316565,
-0.0050032786,
0.02330399,
-0.00024813105,
0.012557623,
-0.0025749824,
-0.010995096,
-0.019847294,
-0.014375258,
0.0220157,
0.019030953,
0.0025765768,
0.012659666,
0.022819286,
-0.011983633,
0.040970124,
-0.025255555,
-0.0112310685,
0.015459461,
0.012902017,
-0.016900813,
0.015459461,
-0.01505129,
0.017092144,
-0.00964303,
0.020765679,
-0.01483445,
0.0026100595,
0.029541345,
0.00033662116,
-0.04007725,
0.013724736,
0.01808706,
0.005762221,
-0.0046812063,
-0.009827983,
-0.029388282,
0.011575462,
0.0017602356,
0.030893411,
0.00044125473,
0.02969441,
-0.00090403407,
0.024158597,
-0.019464634,
-0.0037883332,
-0.019515656,
-0.012500225,
0.010752744,
0.0075894217,
0.004193315,
-0.014081885,
-0.026913747,
0.0020998463,
-0.023724915,
-0.010172376,
-0.024413703,
0.013763002,
-0.021454467,
-0.013137991,
-0.0013042326,
-0.0066646603,
-0.0066582826,
0.018074304,
-0.011039739,
-0.022104988,
-0.0061098034,
0.0129913045,
0.017015612,
-0.0053827497,
0.011141782,
-0.019553922,
-0.022436626,
0.0057048216,
0.01835492,
0.009930025,
-0.0034407505,
-0.020510571,
-0.01158184,
-0.0046812063,
0.008341987,
0.0019148941,
0.016543664,
-0.0296689,
0.019362593,
-0.0007904319,
-0.0051914197,
0.01155633,
-0.011384132,
-0.016071716,
0.015803855,
0.037602715,
0.005778165,
0.021365179,
-0.009483589,
0.015587014,
0.028827047,
-0.008947864,
0.0041295383,
-0.048725363,
0.0015984024,
0.0112310685,
0.014388014,
0.016467132,
0.008731024,
-0.0138778,
0.02253867,
0.016237536,
-0.016135493,
0.0062564895,
-0.0042634695,
0.01720694,
-0.009145572,
-0.0053444835,
-0.020548837,
0.006671038,
0.010102222,
0.020472307,
-0.033061817,
-0.004898047,
-0.0071366075,
-0.011741282,
0.014706897,
-0.018393187,
0.019222284,
-0.011805058,
-0.0041422937,
0.007583044,
0.007098342,
0.015038535,
0.0009279503,
0.0010842031,
-0.01846972,
0.013622694,
0.031403624,
0.014987513,
-0.024426458,
-0.010095844,
0.044898763,
0.00655624,
0.010331818,
0.015867632,
-0.00069556414,
-0.010848409,
-0.0040466287,
-0.0022752322,
-0.013431364,
-0.007149363,
0.0195029,
0.018992689,
0.0049139913,
0.017002856,
0.0036767242,
0.03704148,
0.013444119,
-0.0044292887,
0.04704166,
0.0030899788,
-0.0008306909,
0.020740168,
0.008354742,
0.017257962,
-0.011505309,
0.0046078633,
-0.0068304795,
0.031786285,
0.020548837,
0.04311302,
-0.022436626,
0.0075001344,
-0.014898227,
-0.024847385,
-0.013125235,
-0.0088968435,
0.011416021,
-0.01748756,
-0.016900813,
-0.009126439,
-0.016683973,
0.010771877,
-0.017411027,
0.014426279,
0.019541167,
-0.008163412,
0.0045472756,
0.023444299,
-0.010491259,
-0.03204139,
-0.019783517,
0.014885471,
0.039107844,
-0.008329231,
-0.02177335,
0.0018527118,
0.017015612,
-0.013865044,
0.02526831,
0.016505398,
0.012034655,
0.018163592,
-0.0016837036,
-0.011875213,
-0.00077648077,
0.01605896,
-0.006144881,
0.026709663,
0.016224781,
0.019847294,
-0.01595692,
-0.031429134,
0.0061990907,
0.031760775,
0.013520651,
0.024171352,
-0.011951745,
0.013201768,
-0.012302517,
-0.0025654158,
-0.0075001344,
-0.020383019,
0.048419237,
0.0141584175,
-0.004783249,
-0.0025558495,
-0.0038648653,
0.029362772,
-0.0019021387,
0.011026983,
-0.019745253,
-0.021837126,
-0.015803855,
0.09086898,
-0.0031888327,
-0.004687584,
0.012168585,
0.011078005,
-0.0046748286,
0.021326913,
-0.0042379587,
0.0063521545,
-0.0073088044,
-0.0021157905,
-0.01032544,
0.0072705387,
-0.012768086,
0.043495677,
0.021339668,
-0.0009813632,
-0.039898675,
-0.009356035,
-0.00540826,
-0.0038776207,
-0.02737294,
0.015331907,
0.009764206,
-0.0012205257,
0.011754038,
0.039949697,
0.015319153,
0.0031569444,
-0.021811616,
-0.02813826,
0.0016151437,
-0.01565079,
0.018099815,
-0.0014030864,
0.012666044,
0.005720766,
-0.025804034,
0.037577204,
-0.023890734,
0.011071627,
-0.006671038,
0.0042156368,
-0.015268131,
0.013176257,
-0.019706987,
0.026097408,
0.022372851,
-0.008010347,
-0.011607351,
0.004856592,
-0.01619927,
-0.0044292887,
-0.009917269,
-0.007359826,
-0.039209887,
-0.00064534,
0.0015800666,
-0.01682428,
0.0028428445,
-0.028776027,
-0.004760927,
0.015319153,
-0.01871207,
-0.01445179,
-0.02155651,
-0.030944433,
0.0031808605,
-0.030306665,
-0.02931175,
0.024668809,
-0.031020965,
-0.025536172,
0.0023198759,
0.015535993,
0.0069389,
0.039669078,
-0.0054401485,
-0.01732174,
-0.000762131,
-0.017194185,
0.025701992,
-0.01253849,
-0.019056464,
0.006285189,
-0.008310098,
-0.021263136,
-0.02737294,
-0.011358622,
-0.008354742,
-0.009413434,
-0.008507806,
0.012653288,
-0.005931229,
-0.014617609,
-0.0046397517,
0.0075639114,
0.012474714,
-0.008131524,
0.014949248,
-0.0006130531,
-0.029031133,
-0.019043708,
-0.0183039,
0.008558827,
-0.019132996,
-0.010414728,
0.00088171224,
0.0028938656,
0.00458873,
0.03494961,
-0.043648742,
0.019171262,
-0.009502721,
0.012136697,
0.019732498,
0.0072067617,
0.01619927,
0.015306397,
-0.031837307,
-0.008137901,
-0.014234949,
0.002941698,
0.027347429,
-0.026275981,
0.0062564895,
-0.0051340205,
-0.029235218,
-0.0392354,
-0.006862368,
-0.03318937,
0.031352602,
0.00049267465,
-0.0038361656,
-0.006600884,
-0.008699136,
-0.0058929627,
-0.007474624,
-0.014171173,
-0.018571762,
0.0016023885,
-0.0171049,
-0.00816979,
-0.03494961,
0.028571941,
-0.034566946,
-0.005969495,
0.0032940642,
-0.015064046,
-0.008316476,
-0.028265813,
-0.01737276,
-0.0154722165,
0.004381456,
-0.009853493,
-0.004139105,
-0.005411449,
-0.010395595,
0.012704309,
0.03119954,
0.0435467,
0.014898227,
0.016747748,
0.037322097,
0.017015612,
0.012710687,
-0.005829186,
0.013699225,
-0.010529526,
0.040766038,
0.034771033,
0.017219696,
-0.0027663123,
0.012251495,
0.013393098,
0.013763002,
0.015905898,
-0.01682428,
-0.0032685534,
-0.044490594,
-0.012181341,
0.0023390087,
-0.0118879685,
-0.00029137958,
-0.040230315,
-0.016161004,
0.010842031,
-0.008520561,
0.0028396556,
-0.025957098,
-0.005663367,
0.00732156,
0.011900724,
-0.0028428445,
-0.02308715,
-0.012953038,
-0.02699028,
-0.005602779,
0.007889172,
0.022270808,
0.0021221682,
0.024758097,
0.0066646603,
-0.018839624,
0.025497906,
0.027832132,
-0.015140578,
0.0022305886,
-0.0037245566,
-0.03196486,
-0.01524262,
-0.019796273,
-0.007570289,
-0.023763182,
-0.012780841,
0.0077616186,
-0.0031107063,
0.007774374,
-0.009700429,
-0.014324237,
-0.0017761798,
0.018559007,
0.014515567,
-0.012060165,
0.018150836,
-0.0017953129,
-0.0074427356,
-0.015319153,
0.034617968,
0.028342346,
-0.002846033,
0.02040853,
0.0024649678,
-0.0011431965,
-0.007946571,
0.016135493,
0.0070218095,
-0.009630275,
-0.03130158,
0.029362772,
0.007551156,
-0.012417315,
-0.00822081,
0.025906077,
-0.030791368,
-0.0077807517,
-0.008954242,
-0.0031712942,
0.011881591,
-0.018686559,
-0.0097259395,
0.031403624,
-0.004949068,
0.01464312,
0.010555036,
-0.007697842,
-0.027041301,
-0.013609938,
-0.025013205,
0.012277006,
0.013711981,
0.018176347,
-0.020064136,
0.0014126529,
0.008048614,
-0.0024793174,
-0.0035364155,
0.005564513,
-0.0042953575,
0.033674072,
-0.005357239,
-0.023482565,
-0.0017028367,
0.012748953,
-0.017296229,
0.017168675,
-0.009694051,
-0.03625065,
-0.013546161,
-0.011097138,
0.006958033,
0.018635537,
0.01811257,
0.010083089,
-0.006176769,
-0.036072075,
-0.014630364,
-0.018533496,
0.022360096,
0.0057654097,
-0.019145751,
-0.015561503,
-0.0019037331,
0.023826959,
0.0021955112,
-0.0095983865,
0.0015282481,
0.013584428,
-0.012959416,
0.028801536,
-0.0029209708,
0.008399385,
-0.025204534,
0.010440238,
-0.022436626,
-0.018291144,
0.025676481,
-0.00816979,
-0.026531087,
-0.04635287,
-0.021658551,
0.006387232,
0.004346379,
0.0038903758,
0.0066646603,
-0.005427393,
0.0031457834,
-0.017525824,
-0.0023884356,
0.049337618,
-0.04176095,
-0.0010052795,
0.023431543,
-0.005073433,
0.017819198,
-0.022372851,
0.029133176,
0.007168496,
-0.010459371,
-0.007825395,
-0.03122505,
0.018865135,
-0.00050303835,
-0.0066582826,
0.008979753,
0.008399385,
-0.015484972,
0.02406931,
0.00080278865,
-0.0038808093,
0.015382929,
0.010044823,
-0.0139670875,
0.011881591,
0.0024139464,
-0.01021702,
0.011817814,
-0.0045855413,
-0.026684152,
-0.013571672,
0.0021668118,
0.049516194,
0.020421285,
-0.02273,
0.012946661,
0.0016406544,
-0.049541704,
-0.018482475,
-0.007168496,
-0.0004894858,
0.01543395,
0.019579433,
-0.011754038,
0.012174963,
0.021849882,
0.010905808,
-0.013163501,
-0.018546252,
0.008010347,
-0.018992689,
0.023635628,
-0.005529436,
0.006524352,
-0.0016278991,
0.02969441,
0.007972082,
-0.0049139913,
0.04461815,
-0.017768176,
0.008150657,
0.0035013384,
0.007799885,
0.001926055,
-0.020064136,
-0.010810143,
-0.03668433,
-0.017219696,
0.004116783,
-0.005092566,
-0.012117565,
-0.001470849,
-0.013393098,
0.0017570468,
-0.017079389,
-0.022819286,
-0.018763091,
0.015178843,
-0.015752833,
0.014910982,
0.016837036,
-0.018686559,
0.02318919,
0.004566408,
0.008080502,
-0.006651905,
-0.0013767785,
0.0009526638,
0.004853403,
-0.018214613,
-0.02062537,
0.009687674,
-0.038674165,
0.021161094,
-0.022411115,
-0.0034248063,
-0.026352514,
-0.021505488,
0.009694051,
0.019630454,
0.01013411,
0.009802472,
0.009789716,
0.010574169,
-0.021977436,
-0.015714567,
-0.008641737,
-0.0027934175,
-0.006575373,
0.0196177,
-0.012589511,
0.013533406,
-0.012143075,
-0.004177371,
-0.04237321,
-0.026173938,
0.037347607,
0.18102366,
-0.002941698,
0.0071174745,
0.0058259973,
-0.0088968435,
0.009477211,
-0.0011854486,
-0.005593213,
0.015140578,
0.041480336,
0.0017379138,
0.013673714,
0.00315535,
0.012168585,
0.011977255,
-0.02890358,
-0.030179113,
-0.013571672,
-0.008590715,
-0.0045026317,
-0.0040083625,
-0.0065817507,
-0.003619325,
-0.009285881,
0.032755688,
0.020038625,
-0.018992689,
-0.0055517578,
0.0081123905,
0.0052520074,
-0.014464545,
-0.0088522,
0.025829544,
-0.00926037,
-0.005430582,
-0.003136217,
-0.021339668,
-0.018954422,
0.010924941,
-0.0050000898,
-0.01693908,
0.015306397,
0.008820311,
-0.015765589,
0.008074124,
0.0074427356,
-0.012296139,
0.015421195,
-0.013916066,
-0.009847116,
-0.015331907,
-0.021275891,
0.025191778,
0.016046206,
-0.003718179,
0.010912186,
0.02423513,
0.0007079209,
-0.0017331305,
0.007072831,
0.025855055,
0.015115067,
-0.016760504,
0.02600812,
-0.00942619,
0.021479977,
-0.009789716,
0.0008880899,
0.014426279,
-0.0060683484,
0.02270449,
-0.01521711,
0.0048374594,
-0.001650221,
0.008641737,
-0.029107666,
0.02239836,
0.020293731,
0.025727503,
0.021977436,
0.016148249,
0.004713095,
0.0012755331,
0.0027679068,
-0.00980885,
-0.022232542,
0.0012165396,
0.012627778,
-0.025191778,
-0.0046046744,
-0.007474624,
-0.0065626176,
-0.015740078,
-0.026939258,
0.016518153,
0.002917782,
0.025995364,
0.016709484,
-0.019375348,
-0.015561503,
-0.034515925,
0.06051129,
0.035816967,
-0.018661048,
-0.0032813088,
-0.0050096563,
-0.00540826,
0.027041301,
0.008775667,
0.008514184,
-0.0010523148,
-0.0327812,
-0.003922264,
-0.010580547,
0.004949068,
0.0024713452,
0.023252968,
-0.048291683,
0.00797846,
-0.010044823,
-0.0068496126,
-0.011741282,
0.0061129923,
0.029745432,
-0.0018431453,
0.0052328743,
-0.017296229,
-0.02406931,
-0.00063776656,
-0.025957098,
0.016875302,
-0.017066633,
0.0073725814,
-0.012532112,
0.027500493,
0.020280976,
0.010012935,
-0.009796094,
-0.00027702985,
0.006620017,
-0.0004878914,
-0.012615022,
0.01311248,
-0.011001473,
-0.01243007,
-0.018214613,
0.010012935,
-0.01617376,
-0.018750336,
-0.019184018,
-0.022360096,
-0.005086188,
0.0022162388,
-0.0023581418,
0.0141584175,
-0.026148427,
0.008157034,
-0.052296855,
-0.0060906704,
0.0183039,
-0.022245297,
0.025064224,
0.017882973,
0.008163412,
-0.013214523,
0.013916066,
-0.1588804,
0.039924186,
0.015689056,
-0.036862906,
0.036760863,
0.0076149325,
0.025982609,
-0.0066582826,
0.0040530064,
0.0093432795,
0.011518064,
-0.01464312,
-0.00800397,
0.0027710956,
0.0062054684,
-0.0016805149,
0.0040051737,
0.007723353,
0.027092323,
0.017462049,
0.030255646,
-0.018928912,
0.04704166,
-0.0026610808,
-0.0043208683,
-0.023597362,
-0.01772991,
0.035612885,
-0.0073024267,
-0.02368665,
-0.02163304,
-0.003097951,
0.015204354,
-0.000683606,
-0.012143075,
0.013214523,
0.0046397517,
-0.001367212,
-0.00751289,
-0.004993712,
0.019107485,
0.023559095,
-0.01595692,
0.010542281,
-0.0028364668,
0.0142859705,
0.0116137285,
0.005127643,
0.012857374,
0.016862547,
0.014145662,
-0.016658463,
0.012028277,
0.007602177,
0.02813826,
0.002040853,
-0.029413793,
0.0024809118,
0.0039190752,
0.0010690562,
-0.016161004,
0.0010459372,
0.030383198,
0.0072896713,
0.0022816097,
-0.035306755,
-0.031174028,
-0.009126439,
-0.027143344,
0.009438945,
-0.027321918,
0.011549952,
0.005338106,
0.0035172824,
0.016645707,
0.016632952,
-0.009662163,
0.0034439394,
0.0013488763,
-0.0018925723,
0.0075766663,
0.0012117564,
-0.035051648,
-0.010873919,
-0.009579253,
0.0049139913,
0.00081434817,
-0.010893052,
-0.0062246015,
-0.020344753,
0.017245207,
-0.020306487,
0.006977166,
-0.023673894,
-0.008035858,
-0.009483589,
0.020701902,
-0.0040466287,
0.003622514,
-0.009292259,
-0.011084382,
-0.02699028,
-0.027296407,
0.0037086124,
0.040383376,
0.005446526,
-0.02586781,
-0.0040753284,
0.025855055,
-0.009974669,
-0.003412051,
-0.016263047,
0.014081885,
0.005924851,
-0.019655965,
0.031505667,
0.01603345,
-0.01051677,
0.021786105,
-0.009496344,
0.06015414,
-0.0056569893,
-0.010312685,
0.01794675,
0.0010698534,
-0.036786374,
-0.119593985,
0.028852558,
0.005315784,
0.015255376,
0.015995184,
0.0346945,
-0.0020344753,
0.021543754,
-0.0016629762,
0.041709933,
-0.011403265,
-0.0024825062,
-0.0061098034,
-0.009891759,
0.031837307,
0.0006357735,
0.009885381,
-0.0030580906,
-0.0062246015,
0.043215062,
-0.012449203,
-0.008093257,
-0.0033450855,
-0.013201768,
0.0027551514,
0.008501428,
-0.016569175,
0.015561503,
-0.008144279,
0.022207031,
0.007359826,
0.0050383555,
0.009885381,
-0.009317769,
0.011836947,
-0.0047545494,
0.004898047,
-0.009477211,
0.03081688,
-0.012379048,
0.00050861883,
0.024681564,
0.03160771,
0.005905718,
0.009222104,
-0.020089647,
-0.011824192,
0.0025191777,
0.011365,
-0.017831953,
-0.0011503714,
-0.019694231,
-0.026429046,
-0.032245476,
0.008118768,
0.015638035,
-0.010044823,
-0.007799885,
-0.022717245,
0.011785925,
-0.017793687,
0.022002947,
-0.013042326,
0.011600973,
0.0061863353,
-0.028699495,
-0.041454826,
-0.032449562,
-0.004442044,
-0.032143433,
-0.022844797,
0.018954422,
-0.009018019,
-0.009005263,
-0.031020965,
0.014821694,
-0.020497818,
0.007187629,
0.019949337,
0.004977768,
-0.018814113,
-0.015638035,
0.011658372,
-0.015689056,
0.004253903,
-0.009209349,
0.011703016,
0.007697842,
0.005666556,
-0.0122706285,
0.003775578,
0.032908753,
-0.0017586412,
-0.03318937,
0.0171049,
0.036786374,
-0.011498931,
-0.008157034,
0.026059141,
-0.007697842,
-0.026454557,
-0.00087055133,
-0.036123097,
0.021186605,
-0.0057080104,
-0.008335609,
-0.012162208,
0.005472037,
0.006620017,
-0.0126724215,
-0.005277518,
0.01846972,
0.013520651,
0.02409482,
-0.008762912,
-0.026837217,
-0.026173938,
0.0037213678,
0.012277006,
0.034005713,
0.030918922,
0.011709394,
0.0032573927,
0.012474714,
-0.009866249,
0.019388102,
-0.019630454,
-0.0026052764,
0.00611937,
0.025523417,
-0.007219517,
-0.0001800694,
0.010848409,
-0.03974561,
-0.0138778,
0.0014533105,
-0.004155049,
-0.047960043,
0.003679913,
0.01445179,
0.006907012,
0.025510661,
-0.030995455,
-0.0013967088,
-0.0025973043,
-0.02699028,
-0.009356035,
0.014732407,
0.0009757828,
0.026582109,
-0.0081953,
-0.008558827,
0.019821784,
0.0053668055,
-0.026582109,
-0.023074394,
-0.02928624,
-0.015191599,
-0.008539694,
0.011384132,
-0.0015593392,
-0.03778129,
0.019426368,
0.019298816,
0.0092795035,
0.009381546,
0.009719562,
-0.026327003,
0.00010891857,
0.0003408065,
0.014324237,
-0.014962003,
-0.029184196,
-0.011154537,
0.007940194,
0.006409554,
-0.020727413,
-0.0021684063,
0.019898316,
0.026148427,
-0.0052456297,
0.00056163315,
-0.0005927243,
0.019184018,
-0.004084895,
0.029388282,
0.02308715,
-0.0022768266,
-0.009190216,
0.0026339758,
0.019158507,
0.003274931,
-0.033342436,
0.01734725,
-0.001352065,
0.014196684,
-0.0171049,
0.006913389,
-0.00808688,
-0.016250292,
0.011237446,
0.023176435,
-0.015803855,
-0.0022576936,
-0.024656054,
-0.008903221,
-0.015638035,
0.027806621,
-0.0052870847,
-0.018967178,
-0.029592367,
0.00961752,
0.025829544,
0.015293642,
-0.008756534,
-0.01185608,
0.008214433,
0.023023373,
-0.016696729,
0.010542281,
-0.0012779247,
0.03045973,
-0.00064254977,
0.022028456,
-0.0059344177,
-0.0020854967,
0.027296407,
0.0013767785,
0.020446796,
-0.0195029,
0.020178933,
-0.015459461,
0.034031224,
-0.022028456,
-0.047858,
0.01732174,
-0.019324327,
0.0065434845,
0.036888417,
0.014962003,
0.0103828395,
0.038776204,
0.019018197,
0.0046780175,
-0.008966997,
-0.0050542997,
0.008424896,
-0.0026961581,
0.017653378,
-0.01600794,
-0.03267916,
0.007742486,
-0.015382929,
-0.0030612794,
-0.046072256,
0.0037309343,
0.010165999,
-0.0177044,
0.019630454,
-0.00007957134,
-0.0009327336,
0.015612525,
0.02371216,
0.011620106,
0.012742575,
-0.033980202,
0.0005640248,
0.020803945,
-0.0034279951,
-0.0040561953,
-0.018431453,
-0.01185608,
-0.003753256,
-0.029184196,
-0.0081761675,
-0.0009167894,
-0.0076659536,
0.005787731,
-0.0103828395,
0.012978549,
-0.013393098,
0.0012404559,
0.013291054,
0.012168585,
-0.017168675,
0.004706717,
-0.004186937,
-0.01081652,
-0.012168585,
0.009923647
] |
How to manage the preterm patent ductus arteriosus (PDA) remains a conundrum. On the one hand, physiology and statistical association with adverse outcomes suggest that it is pathological. On the other hand, clinical trials of treatment strategies have failed to show any long-term benefit. Ultrasound studies of PDA have suggested that the haemodynamic impact may be much earlier after birth than previously thought (in the first hours); however, we still do not know when to treat PDA. Studies that have tested symptomatic or pre-symptomatic treatment are mainly historical and have not tested the effect of no treatment. Pro | [
-0.008108605,
0.0073653157,
0.033110134,
-0.035191342,
-0.026447566,
0.021920262,
-0.020730998,
0.03159653,
-0.030191038,
0.0089870365,
-0.0120818205,
0.018095702,
0.0008079042,
0.029434234,
0.008243748,
-0.019379565,
0.038515873,
-0.01858222,
0.007095029,
-0.011784505,
-0.028001714,
0.004983413,
-0.030299153,
0.0055341227,
-0.029082863,
0.0093654385,
0.0346778,
-0.018609248,
-0.008973522,
-0.017284842,
-0.003412371,
0.003608329,
-0.010358742,
-0.019433623,
0.00071034755,
0.0047638053,
-0.00062757224,
-0.0025373176,
0.020068796,
-0.007797775,
0.009453282,
-0.0055543943,
0.0006469991,
-0.021758089,
-0.028407145,
-0.0005507094,
-0.013514341,
-0.019487679,
-0.0008083265,
0.012331836,
0.029190976,
-0.0035644074,
-0.0042637745,
0.0066558127,
0.0011689905,
0.005179371,
-0.010068184,
0.041002512,
-0.00028000024,
-0.027434113,
-0.0020406656,
-0.010081698,
-0.014487374,
0.012595366,
-0.022055404,
0.00063770794,
0.0051117996,
0.037461754,
0.0058517097,
0.042137716,
0.04040788,
0.026717853,
0.0012179799,
-0.011325018,
0.0076356027,
-0.0074734306,
-0.021663489,
-0.02462313,
-0.010737144,
0.019203879,
0.012879167,
-0.025596162,
-0.0011216903,
0.028001714,
0.01220345,
-0.016419925,
0.0068686637,
0.018703848,
-0.026880024,
-0.009196509,
-0.0044225683,
0.011919648,
0.0036319792,
0.012744023,
0.0088924365,
0.010034398,
0.020555312,
0.021852689,
0.016501011,
-0.022190548,
-0.00076524954,
-0.013021068,
-0.017163213,
-0.014473859,
-0.006426069,
0.005986853,
-0.0012382515,
-0.0049327346,
0.0023599418,
-0.007716689,
-0.032893907,
0.054489825,
-0.02144726,
-0.009919526,
0.032866877,
-0.013318383,
0.004480004,
0.015095519,
-0.011250689,
0.0112304175,
0.033299338,
0.0022146627,
0.026515137,
-0.0058719814,
0.0064159334,
0.021312116,
-0.03651575,
-0.004544197,
0.021393202,
-0.007966704,
-0.011649362,
0.020933714,
0.025906991,
-0.0058618453,
-0.029299092,
0.005067878,
-0.03605626,
-0.0045408187,
-0.02462313,
-0.037002265,
0.02932612,
0.016636154,
-0.028650403,
-0.02294735,
-0.022798693,
0.028974747,
0.0277044,
0.022082433,
0.0030136982,
-0.00384483,
0.0014088701,
-0.021258058,
-0.021677002,
-0.0077504744,
-0.014811718,
0.010797959,
0.0174335,
0.010595243,
-0.0104601,
0.0031336378,
-0.008797836,
0.015987465,
-0.004621905,
0.0067841993,
0.014149515,
0.009669511,
-0.012798081,
0.0037367153,
0.010602,
-0.02652865,
-0.012494008,
0.0059226598,
-0.035623804,
0.0031167448,
0.0017653108,
0.014122486,
-0.017974073,
0.011879106,
-0.024352843,
-0.02727194,
-0.015041461,
-0.023866326,
0.008838379,
0.03997542,
-0.023325752,
-0.0021082372,
0.012649423,
-0.004311075,
0.018906564,
-0.025298847,
0.0065781055,
0.013298112,
-0.022433806,
-0.00787886,
-0.63484967,
-0.009446524,
-0.013825171,
-0.016555067,
0.0014561702,
0.014960376,
0.0085613355,
-0.011027702,
-0.0049158414,
0.032488476,
-0.012602123,
0.014581974,
-0.018474104,
0.00850052,
0.006034153,
-0.009277595,
0.010419557,
-0.01537932,
0.011352046,
-0.009662754,
0.005125314,
0.02512316,
-0.0122710215,
0.0066355416,
0.024839358,
0.023690639,
0.015487435,
0.01874439,
-0.012183178,
0.012926467,
-0.0026809075,
0.006669327,
-0.024879903,
0.009845197,
0.047840767,
-0.007088272,
-0.011135817,
0.024879903,
-0.0042333673,
0.031893846,
-0.00036340908,
0.0060071247,
0.025825907,
0.008351862,
-0.011960192,
0.009487067,
0.032137103,
-0.027312484,
0.0035306215,
-0.005378708,
0.011899377,
-0.009628968,
-0.0026623253,
0.011297989,
0.011210145,
-0.015325263,
0.017217271,
-0.023933899,
0.005956446,
-0.01898765,
0.019379565,
0.00764236,
0.02462313,
-0.01967688,
0.0007952345,
0.027866572,
0.005807788,
0.021082371,
-0.025771849,
0.019433623,
-0.010852016,
0.04840837,
0.013169725,
-0.0031657345,
0.029731551,
0.01609558,
0.023852812,
0.025298847,
-0.016865898,
0.02543399,
0.0020136368,
0.0026944217,
-0.014068429,
0.025271818,
0.033110134,
0.004125253,
-0.01960931,
0.019974196,
-0.008419435,
-0.015919894,
-0.010250628,
0.015257691,
-0.0013531233,
-0.01917685,
0.008162662,
0.027812514,
-0.008824864,
-0.006513912,
-0.001091283,
0.020244483,
-0.009689783,
-0.0030221445,
-0.00881135,
-0.00666257,
0.033758823,
0.01786596,
-0.016663183,
-0.011243932,
0.0315695,
-0.037596896,
0.00040986462,
-0.0075883027,
0.013973828,
-0.0029376799,
0.036191404,
-0.026974624,
-0.011446646,
-0.027785486,
0.0065206694,
-0.014595488,
0.019487679,
-0.018271388,
0.009500582,
-0.010980402,
-0.0005688693,
0.020312054,
0.00065164466,
-0.014136001,
0.009960069,
0.00008895181,
0.0023396702,
0.012379136,
0.010284414,
-0.0046083904,
0.00558818,
0.0008919465,
0.027163826,
0.019825539,
-0.016230723,
-0.009892497,
0.0008497142,
0.0037198223,
0.0004654001,
0.008527549,
-0.006419312,
-0.031110013,
0.011885863,
-0.011115545,
-0.016230723,
0.019879596,
-0.03440751,
-0.03243442,
-0.006344983,
0.02767737,
-0.00663892,
-0.01662264,
0.028082801,
-0.030055894,
-0.017771358,
-0.013723813,
-0.0088924365,
0.013365683,
-0.026379993,
0.008392406,
-0.016609125,
-0.028839603,
-0.008243748,
0.009845197,
-0.019784994,
-0.015460406,
0.0012593677,
-0.014392774,
0.006899071,
0.00034989475,
-0.005888874,
-0.022366235,
0.0035171073,
-0.026569195,
-0.03592112,
0.012676452,
-0.014054915,
-0.02521776,
0.0068686637,
-0.007946433,
0.03567786,
0.025177218,
0.01619018,
0.0041657956,
-0.024285272,
0.024515014,
-0.013372441,
0.022487864,
-0.024325814,
0.028488232,
-0.019487679,
-0.011149331,
-0.0073923445,
0.001824436,
-0.005466551,
0.04040788,
0.017460529,
-0.00048440465,
0.030893784,
-0.01024387,
0.011284475,
-0.023177095,
0.012061549,
-0.017852444,
0.009689783,
-0.010791201,
-0.01793353,
0.00091644126,
0.011277718,
-0.029758578,
-0.03340745,
0.04281343,
-0.0071288147,
-0.019852567,
-0.0064395834,
0.02275815,
0.016149638,
-0.016582096,
0.015014433,
-0.0006866974,
-0.013142697,
-0.009946555,
0.024474472,
0.009993855,
-0.014825232,
-0.043435093,
-0.0066017555,
0.015000919,
0.0021673625,
0.009635725,
-0.004912463,
0.041948516,
0.0093654385,
-0.010973645,
0.030515382,
0.01858222,
-0.0076288455,
-0.008534307,
0.023920383,
-0.0069531286,
-0.0034461569,
0.011399346,
0.03097487,
0.014636031,
-0.027636828,
-0.007290987,
-0.013798142,
0.0023177094,
0.00057182554,
-0.013271083,
-0.013548126,
-0.01786596,
-0.006915964,
0.009378953,
0.01569015,
0.015190119,
0.029434234,
0.019812023,
-0.003959702,
-0.000048303213,
0.021474289,
-0.02182566,
0.029623436,
-0.0025896856,
0.0077842604,
-0.020501256,
-0.024136612,
-0.014460345,
0.019528223,
-0.033164192,
0.034245342,
0.010169541,
-0.00015024147,
0.01867682,
0.015352291,
-0.0019528223,
0.001174903,
-0.029028805,
0.010649301,
0.02244732,
0.00029119183,
-0.020474227,
0.016852383,
0.007939676,
-0.025163703,
-0.0012365622,
-0.0031150556,
-0.011304746,
0.006321333,
0.0050611207,
-0.0012931535,
-0.029488292,
0.024298785,
0.020771543,
0.010574972,
-0.004385404,
-0.012007492,
0.012433194,
-0.02873149,
-0.027947657,
0.023150066,
0.01506849,
-0.008723507,
-0.025988078,
0.0059260386,
-0.002337981,
-0.0095073385,
-0.028001714,
-0.013129182,
0.0029140299,
-0.0077099316,
0.0064497194,
0.007872104,
0.014676575,
0.032488476,
0.006091589,
-0.005203021,
0.0020930336,
-0.007250444,
-0.0044495966,
0.037245523,
-0.015433378,
0.027920628,
0.023136552,
-0.00871675,
0.003909023,
-0.0028126722,
-0.03402911,
0.036542777,
0.010899316,
0.01836599,
0.0032941205,
0.0046894765,
0.006557834,
0.009068123,
0.022298662,
0.0058517097,
-0.01998771,
-0.009865469,
-0.007926161,
0.00062799454,
-0.00929111,
0.023731183,
0.032974992,
0.016555067,
-0.0013573467,
0.014176544,
0.015892865,
0.0112304175,
0.009493825,
-0.028866632,
0.011865592,
-0.000022211558,
0.045651443,
-0.009007309,
-0.010635787,
0.024974503,
-0.0140414005,
0.009088394,
0.04143497,
0.015771236,
0.01637938,
0.00628079,
-0.000803681,
0.007770746,
-0.0074464018,
0.016649669,
-0.004331346,
0.01619018,
-0.017879473,
0.026379993,
-0.00046624476,
-0.0060814535,
-0.0071017863,
0.06113888,
0.0068686637,
-0.0023548738,
0.0032772277,
0.020771543,
0.016082065,
-0.0094600385,
-0.007040972,
0.008628907,
0.0026657039,
0.0056152088,
-0.020136368,
-0.024163641,
-0.007372073,
-0.017514586,
-0.009872226,
-0.010993917,
0.0010718561,
-0.026298909,
0.023677126,
0.022555435,
0.0029934265,
0.018514648,
0.00027725517,
0.011946677,
0.018338962,
-0.005676023,
-0.018947106,
-0.004645555,
-0.013906257,
0.021528345,
0.0073991017,
-0.026042135,
-0.0065375627,
-0.01506849,
0.022582464,
0.029055834,
-0.004382025,
0.011710176,
-0.00929111,
0.00018898961,
0.01354137,
0.01497389,
0.020379627,
-0.01296701,
-0.017325385,
-0.009939798,
-0.010108727,
-0.013298112,
0.0007078136,
0.0032755383,
-0.016784811,
-0.015054976,
-0.0023396702,
-0.00556453,
-0.025231274,
0.038029354,
-0.0043381033,
-0.0068450137,
-0.022677064,
0.033542596,
0.023677126,
-0.031001898,
0.033110134,
0.025825907,
-0.005784138,
-0.022150004,
0.005179371,
0.03894833,
0.01569015,
-0.0059192814,
0.023758212,
0.00048060375,
-0.020812085,
-0.06497695,
0.010250628,
-0.005767245,
0.025204247,
0.013818414,
-0.02521776,
-0.05535474,
-0.00083831145,
-0.008466735,
-0.007716689,
-0.015906379,
-0.01143989,
0.0041860673,
0.0039867307,
-0.018311933,
-0.010500643,
0.04121874,
-0.035191342,
-0.019433623,
0.0057807593,
-0.018474104,
0.0031082984,
-0.012784567,
-0.004091467,
-0.0052435645,
0.0026978003,
-0.015609064,
-0.063679576,
0.0054057366,
-0.025636705,
0.01239265,
0.008953251,
0.013500826,
-0.01265618,
-0.0038549658,
0.040164623,
0.014541431,
0.0060172603,
-0.009473553,
-0.0056050727,
-0.018609248,
0.03362368,
0.005888874,
0.013777871,
0.029407207,
-0.0045171683,
0.025474533,
0.0072639585,
-0.010115485,
-0.014460345,
-0.0024275135,
-0.027920628,
-0.013554884,
-0.004885434,
-0.00020377092,
-0.004726641,
-0.041489027,
0.008014005,
0.0072639585,
0.0075207306,
-0.008743779,
-0.025204247,
0.015798265,
-0.008905951,
0.03265065,
0.011406104,
0.013527855,
0.008385649,
-0.006980157,
-0.010108727,
0.0059530674,
-0.008723507,
-0.0020643156,
0.01821733,
0.029704522,
-0.018068673,
-0.020933714,
-0.007777503,
-0.023825783,
-0.016609125,
0.0026184036,
-0.0059665814,
-0.009757354,
-0.0068416353,
-0.011791263,
-0.043840524,
0.027663857,
0.00384483,
-0.0039259163,
0.027866572,
-0.034245342,
-0.004405675,
-0.006402419,
-0.01824436,
-0.00983844,
-0.006980157,
0.03551569,
0.029569378,
-0.014784689,
-0.021568889,
-0.028839603,
-0.004311075,
0.010081698,
0.01848762,
-0.0023160202,
0.0055510155,
-0.025866449,
0.014636031,
0.040299766,
-0.020163396,
-0.025042074,
0.032893907,
0.0035644074,
-0.017501071,
0.010372257,
-0.03770501,
-0.009047851,
0.013095397,
-0.008351862,
0.017582158,
-0.012473737,
-0.027920628,
0.0018227467,
0.0020981014,
-0.025325876,
0.04673259,
0.007872104,
-0.00030027176,
-0.011838563,
-0.0028278758,
-0.0023802132,
-0.008601878,
0.0023346024,
0.0031218128,
0.009757354,
0.006094968,
-0.00025107112,
-0.0091289375,
0.011811534,
-0.018703848,
-0.029920751,
0.033731796,
0.0044529755,
-0.018893048,
0.034839973,
0.00446649,
-0.004838134,
-0.025569133,
-0.012602123,
-0.03997542,
-0.032407388,
-0.0071828724,
0.018393017,
0.026096193,
-0.0063247117,
-0.016068552,
-0.013473798,
-0.016244238,
-0.0052368073,
-0.013352169,
0.00030808474,
-0.015392834,
-0.039488904,
-0.011676391,
-0.026501622,
0.0036826578,
0.0008497142,
-0.014014372,
0.008365377,
0.005017199,
0.0067808204,
0.033569623,
0.0073991017,
0.0031893845,
-0.0017095641,
0.018230846,
-0.03362368,
-0.00279409,
0.002758615,
0.0013978897,
0.0044766255,
0.0011867281,
0.008297806,
0.011885863,
-0.011460161,
0.0011352047,
-0.008250506,
0.028974747,
-0.0015304991,
0.009865469,
-0.015649607,
0.011250689,
-0.0052503217,
-0.02266355,
0.01824436,
-0.020285025,
-0.009595182,
-0.005304379,
0.005888874,
0.008899193,
-0.025528591,
-0.0063753906,
-0.03197493,
0.0140414005,
-0.037921242,
-0.006774063,
-0.020217454,
-0.011960192,
-0.026596224,
0.008108605,
-0.004023895,
-0.019528223,
-0.003919159,
0.008493763,
-0.032299276,
-0.00907488,
-0.034812942,
0.0114196185,
0.015852323,
-0.009439767,
-0.015500949,
-0.0007568031,
-0.021582402,
0.03551569,
0.042732347,
-0.020717485,
-0.0143252015,
0.02655568,
-0.042353943,
-0.006622027,
-0.010385771,
0.020366112,
0.020028254,
0.015622579,
0.008872165,
0.010534429,
0.006426069,
0.0027687505,
-0.008527549,
-0.016271267,
0.021420231,
-0.002407242,
0.03321825,
-0.01812273,
-0.0381645,
-0.03265065,
0.007986976,
-0.0068619065,
0.021460773,
-0.0027096253,
-0.0068787998,
0.014946861,
0.0047469125,
0.003909023,
0.0054935794,
-0.013054853,
-0.005155721,
-0.021974318,
0.0094600385,
0.015852323,
-0.0067064916,
-0.034731857,
-0.0059733386,
-0.003204588,
-0.0045577115,
0.0011453404,
-0.0088924365,
-0.0016783122,
0.004104981,
-0.021677002,
-0.003371828,
-0.004544197,
-0.03940782,
0.013690027,
0.028190915,
-0.0072099008,
-0.016068552,
0.012122364,
0.012162907,
0.0042401245,
0.011325018,
-0.019244421,
-0.0073991017,
-0.0023481168,
0.0044529755,
-0.01528472,
-0.014581974,
-0.020163396,
0.0020288404,
-0.026082678,
0.02543399,
0.0049327346,
0.0041016024,
-0.009777626,
0.0040509235,
-0.023406839,
0.0144198015,
-0.007804532,
0.01690644,
-0.025420476,
0.0064801266,
-0.011189874,
-0.030623497,
0.018014617,
0.0048347553,
-0.0072707157,
-0.009554639,
0.005125314,
0.17579454,
-0.005355058,
-0.010487129,
0.003059309,
-0.004496897,
-0.013311625,
0.01282511,
0.00021285088,
-0.017987588,
-0.0055206083,
0.020987771,
0.0030930948,
-0.022933837,
-0.00052114675,
0.034704827,
-0.023041952,
-0.017082127,
-0.030055894,
-0.008507278,
-0.014406287,
-0.0069024498,
-0.015325263,
0.02524479,
0.010933102,
0.0137575995,
-0.006669327,
-0.006084832,
0.0031978309,
0.032461446,
0.021866204,
-0.01239265,
0.0057402165,
0.02213649,
0.017501071,
0.010250628,
-0.010527671,
-0.006476748,
-0.011088517,
0.0096492395,
-0.019501194,
0.0023058844,
0.023244666,
-0.028434174,
0.00040690837,
-0.022271633,
0.028461203,
0.007818046,
-0.039759193,
0.0013894432,
-0.0122237215,
-0.01640641,
0.0015490813,
0.034704827,
-0.008074819,
-0.04965169,
-0.025988078,
0.005523987,
0.03056944,
-0.010993917,
0.024650158,
-0.009662754,
0.006557834,
-0.0068078493,
0.012662938,
-0.024177156,
0.013162968,
-0.009845197,
0.011635847,
-0.0039732163,
-0.010824987,
0.008926222,
-0.0311911,
-0.022623006,
0.012358865,
-0.017203756,
-0.014406287,
0.019203879,
0.016487496,
-0.003503593,
0.011284475,
0.00051692355,
-0.020906685,
-0.037840154,
-0.01444683,
-0.015487435,
-0.028136859,
-0.0018784933,
0.019528223,
-0.006020639,
-0.0013953557,
0.0058213025,
-0.00084549095,
-0.029839665,
0.0019781617,
0.01898765,
-0.014527917,
-0.005392222,
0.017703786,
0.019136308,
0.023582526,
-0.0050070635,
0.06394986,
0.035002142,
-0.006811228,
-0.0032012095,
0.0003374362,
-0.012980524,
0.042975605,
0.0045239255,
-0.015527978,
0.000040094306,
-0.009858712,
-0.006196325,
-0.021987833,
-0.005246943,
0.032110073,
0.005175993,
-0.0057807593,
-0.0029478157,
0.0124602225,
0.002297438,
-0.030164009,
-0.006899071,
0.02698814,
-0.005703052,
-0.02615025,
-0.007770746,
0.012412922,
-0.005523987,
-0.025082616,
-0.00087589823,
-0.011061488,
-0.014595488,
-0.010324957,
-0.0095073385,
0.021906747,
0.0047671837,
-0.0073382873,
-0.0038515872,
0.038272616,
-0.006034153,
0.0029968051,
0.023366295,
0.036137346,
0.015609064,
-0.029299092,
0.03097487,
-0.023001408,
-0.012230478,
-0.009331653,
0.0028616616,
-0.0017104088,
0.025690762,
-0.020960743,
0.010737144,
-0.026393509,
-0.02206892,
-0.024285272,
0.0030035623,
0.0025829284,
-0.0114196185,
0.01435223,
0.019393079,
-0.009689783,
0.0038988874,
-0.013331898,
-0.17049693,
0.01774433,
0.0038684802,
0.023001408,
0.021771604,
0.00015636515,
0.04038085,
0.0063652545,
-0.02390687,
0.0094127385,
0.030866755,
0.018379504,
0.0013168036,
-0.009520853,
0.009574911,
0.014338716,
-0.014703603,
0.030866755,
0.015244177,
-0.017379442,
-0.0010819919,
-0.010304685,
0.02686651,
-0.01848762,
0.008291048,
0.008419435,
-0.00092235376,
0.015744207,
-0.014541431,
-0.020960743,
-0.018163275,
-0.015744207,
0.029812636,
0.0036015718,
0.006412555,
-0.014744146,
0.011520976,
-0.030596469,
0.0047705625,
0.03756987,
0.0045036543,
0.025879962,
-0.0027907114,
-0.020730998,
-0.004912463,
0.010831744,
-0.00983844,
-0.0054935794,
0.02232569,
-0.020352598,
0.002366699,
-0.007986976,
0.0031944523,
0.010237114,
-0.014649546,
0.0064564766,
-0.019460652,
0.013406226,
-0.0088924365,
-0.024312299,
0.00047173497,
0.012602123,
0.009014065,
0.031082984,
-0.00042908033,
-0.0071288147,
0.013244054,
0.007926161,
-0.032028988,
0.014473859,
-0.022528406,
-0.021595918,
0.0052131573,
-0.018879535,
0.02085263,
-0.0054868227,
-0.024731245,
0.019622823,
-0.006149025,
0.009892497,
-0.006500398,
0.010257385,
-0.01466306,
-0.018230846,
0.011669634,
0.023258181,
0.010581729,
0.024420414,
0.014473859,
0.0135210985,
0.030055894,
-0.0346778,
0.009034337,
-0.011635847,
0.0015321884,
0.02400147,
0.005165857,
0.001547392,
-0.004351618,
-0.041516054,
0.020595856,
-0.0075545167,
-0.009899255,
0.0020068795,
0.028650403,
0.017122671,
-0.005199643,
0.0014223844,
0.041516054,
-0.011027702,
0.0013733949,
0.00737883,
0.016568583,
0.023312239,
0.0035644074,
0.035542715,
0.008595121,
-0.0067335204,
0.00057942735,
-0.029650465,
0.04778671,
0.001685914,
0.022541922,
0.028785547,
0.008459978,
-0.016419925,
-0.13449472,
-0.028190915,
0.023041952,
0.0007297744,
-0.00737883,
-0.00035897468,
0.009676268,
0.006750413,
-0.021055343,
0.012365622,
-0.016825354,
-0.035218373,
-0.004621905,
-0.007223415,
0.0350562,
-0.036840092,
-0.0032518883,
-0.025258303,
-0.019311992,
0.023460897,
-0.008466735,
-0.013007553,
0.016609125,
-0.023582526,
-0.017365929,
-0.011000673,
-0.016203694,
0.008777564,
0.008108605,
-0.011068245,
0.028812574,
0.008804593,
0.013176482,
-0.011926406,
-0.027217884,
-0.015473921,
0.00003946082,
-0.0146090025,
0.04721911,
-0.02574482,
0.0012999107,
-0.011575033,
0.03151544,
0.016473982,
0.017474042,
-0.042975605,
-0.042732347,
0.022474349,
0.011575033,
-0.026474593,
-0.023231152,
-0.020447198,
-0.0060544247,
0.011629091,
0.016109094,
-0.036813065,
-0.00028063374,
0.0066929776,
0.005490201,
-0.010034398,
-0.009149209,
0.011054731,
-0.01681184,
0.02029854,
0.01681184,
-0.019541737,
-0.0125075225,
-0.015311749,
0.018474104,
-0.027312484,
-0.02739357,
0.002402174,
0.0032518883,
-0.0019899867,
-0.015919894,
0.010852016,
-0.016460467,
-0.009554639,
0.016176667,
-0.011838563,
-0.010791201,
-0.013879228,
0.0053077573,
-0.0069531286,
0.035596773,
0.007534245,
-0.0029984943,
-0.024271756,
0.0013725503,
-0.009568154,
-0.0150820045,
0.025596162,
-0.00012996995,
-0.017784873,
-0.029650465,
0.02400147,
-0.0030491732,
-0.025366418,
0.014487374,
0.023785241,
-0.033083107,
-0.015771236,
-0.039515935,
0.0029731551,
0.012676452,
0.013933286,
-0.01528472,
-0.0070477286,
0.018595733,
0.03151544,
0.02505559,
-0.01998771,
-0.046219047,
0.019203879,
-0.0053719506,
-0.016595611,
-0.0043212106,
-0.0109466165,
0.025393447,
0.008250506,
0.018730877,
0.002598132,
-0.0008332436,
-0.0017754466,
-0.0025727926,
0.014487374,
0.012541308,
0.00011223238,
-0.0031268806,
0.006067939,
-0.00033046788,
0.0058719814,
0.006507155,
-0.042597204,
0.018568704,
-0.0011968638,
-0.014095457,
0.0018801827,
-0.017325385,
0.015960436,
0.020285025,
0.035164315,
-0.008480249,
-0.01786596,
0.014217087,
-0.022433806,
0.0125075225,
0.019406594,
-0.029028805,
0.013838685,
0.0077099316,
-0.02452853,
0.012615637,
-0.00064615445,
-0.017230785,
-0.024393385,
-0.017163213,
-0.009561396,
-0.024379872,
0.0013641038,
-0.006804471,
-0.0023447382,
0.04511087,
-0.0064699906,
-0.019947167,
-0.0024444065,
0.011156089,
-0.00079227827,
-0.008885679,
-0.0014435005,
0.017555129,
-0.006013882,
-0.007135572,
-0.01814976,
-0.0074261306,
-0.00417931,
0.03343448,
-0.01628478,
-0.017974073,
0.0066929776,
-0.0063889045,
0.019541737,
0.0032130345,
0.006774063,
-0.020717485,
0.006189568,
0.031272184,
-0.013440012,
-0.004909084,
0.016365867,
-0.000121312325,
0.015446892,
-0.024582587,
0.0036319792,
-0.0011352047,
0.023460897,
-0.006297683,
0.0070342147,
0.011473675,
-0.013507584,
-0.012021006,
0.01637938,
-0.011365561,
0.020433683,
0.0051286924,
0.005449658,
-0.025015045,
-0.008520792,
-0.006476748,
-0.034975115,
-0.0070747575,
0.011264203,
-0.0017137873,
-0.0050070635,
0.009014065,
0.00881135,
-0.0056050727,
0.004652312,
-0.008304562,
-0.013561641,
-0.0066355416,
0.013291354,
-0.013318383,
0.023960928,
-0.0055037155,
0.007946433,
0.027785486,
-0.014027886,
0.029785607,
-0.020501256,
0.042840462,
0.011933163,
-0.00021411784,
0.001397045,
-0.024663672,
-0.03097487,
0.025015045,
-0.015825294,
0.014176544,
0.02051477,
0.011115545,
0.083194286,
0.0010203328,
-0.018595733,
-0.0013168036,
0.0057064304,
0.021879718,
-0.0024967745,
0.0060172603,
0.000012729084,
-0.023420352,
0.03116407,
0.012142636,
0.016041523,
-0.0008446463,
-0.0025542104,
0.014054915,
0.006720006,
-0.0066287844,
-0.004702991,
0.010500643,
0.014244116,
-0.008149148,
0.010128998,
0.010345228,
-0.025555618,
-0.017014556,
0.02829903,
-0.0016935158,
0.008946494,
-0.027542228,
-0.008750536,
0.022014862,
-0.026055649,
-0.0278936,
0.0021960805,
0.0015896243,
-0.035380546,
-0.0075815455,
0.00983844,
0.014068429,
-0.0068314993,
0.02758277,
-0.01602801,
-0.02278518,
-0.03343448,
-0.022812208,
0.015433378,
-0.025136674,
-0.01239265
] |
Countries have reached universal health coverage by different paths and with varying health systems. Nonetheless, the trajectory toward universal health coverage regularly has three common features. The first is a political process driven by a variety of social forces to create public programmes or regulations that expand access to care, improve equity, and pool financial risks. The second is a growth in incomes and a concomitant rise in health spending, which buys more health services for more people. The third is an increase in the share of health spending that is pooled rather than paid out-of-pocket by households. This pooled share is sometimes mobilised as taxes and channelled through governments that provide or | [
0.00761124,
0.01014832,
0.012196014,
-0.043890197,
0.00030143923,
-0.008924855,
-0.003390286,
-0.014424008,
-0.022048127,
-0.0036349788,
-0.002636889,
0.0064489483,
-0.00028513977,
-0.006780572,
0.0029475847,
0.009761963,
0.035364576,
-0.004768294,
-0.002881582,
-0.006168839,
-0.027740458,
0.0032019366,
0.00025133352,
0.007411622,
-0.007772222,
0.020914812,
0.022756448,
-0.020348154,
0.017192902,
0.0016613366,
0.0049614725,
-0.013509629,
-0.022292819,
-0.009993777,
-0.027405616,
0.01576338,
-0.0045783347,
-0.019317867,
-0.00039662,
-0.012363436,
0.027663186,
0.003551268,
0.01204791,
0.017424718,
-0.011197924,
0.0009988948,
-0.0040470934,
-0.0005264119,
-0.035210036,
0.029054074,
0.0042370525,
0.013754322,
-0.047959827,
-0.0039730417,
-0.003515852,
-0.01658761,
-0.01947241,
0.006117325,
0.007102536,
-0.0273541,
-0.0070445826,
-0.0014955249,
-0.03796605,
0.0005718894,
-0.035570633,
-0.0055667656,
0.00057591393,
0.011281635,
0.0050677205,
0.013638414,
0.02835863,
0.026079122,
0.007186247,
0.00020867321,
0.0011268756,
-0.0026159612,
-0.023516284,
-0.0105282385,
-0.018519396,
0.012350557,
-0.00084435183,
-0.0025805451,
-0.00842903,
-0.007134733,
-0.001160682,
0.014089165,
-0.0015518687,
0.05009767,
0.009723327,
-0.002192578,
0.012833504,
-0.00743094,
-0.012402072,
0.0060336143,
0.0025467388,
0.004088949,
0.011294513,
0.014797487,
0.019742861,
-0.01640731,
-0.025705643,
0.018892875,
-0.045538653,
-0.0152611155,
-0.034360047,
-0.0041469024,
-0.008924855,
0.010914596,
0.0150550585,
-0.022215549,
0.0013200543,
0.025538221,
-0.017926982,
-0.015698988,
0.030882832,
-0.018983025,
-0.022485998,
-0.008255169,
0.018686818,
-0.017746681,
-0.005003328,
0.01747623,
0.009304773,
0.014591429,
0.0027882124,
-0.019279232,
-0.0080748685,
0.016922452,
-0.0052512405,
0.0016275303,
-0.016265646,
0.004864883,
-0.0032615,
0.010888838,
-0.019742861,
0.019536804,
-0.017733803,
-0.0038217183,
-0.030857075,
-0.019420896,
0.021970855,
0.0055860835,
-0.014849002,
-0.0012572713,
0.01830046,
0.040335707,
0.01938226,
0.014990666,
-0.000034736946,
0.0066582253,
0.005173969,
-0.02347765,
0.0010648975,
-0.012917214,
-0.00824873,
0.02383825,
0.0075339684,
0.019420896,
-0.002427612,
-0.014552793,
0.0011816096,
0.0117323855,
-0.0021748699,
-0.0017901225,
-0.009143791,
0.016729273,
0.002672305,
0.012736915,
0.0028316774,
0.028564688,
-0.008474105,
0.034849435,
-0.013702808,
-0.014668701,
0.008854023,
0.014205072,
-0.005753505,
0.027946515,
-0.05226127,
-0.0021040377,
0.0006290381,
0.007463136,
0.031732816,
0.011655114,
-0.032969162,
-0.0066389074,
0.03224796,
-0.0248299,
0.013187665,
-0.0037347877,
0.009079398,
0.012170257,
0.008042673,
0.0036736145,
-0.65196514,
-0.0023535602,
0.0099873375,
-0.02037391,
-0.002192578,
0.014668701,
0.01495203,
-0.016961088,
-0.03415399,
0.005380026,
-0.011571403,
0.026336694,
0.016136859,
-0.016690638,
-0.014192194,
-0.006213914,
0.0145141585,
-0.04793407,
0.022254184,
0.010129002,
-0.006774132,
-0.00052963156,
-0.012305482,
0.004748976,
-0.007482454,
0.03925391,
-0.002907339,
-0.0017627554,
0.01295585,
0.0015623326,
-0.0047521954,
-0.0013562753,
0.003850695,
-0.0090729585,
0.04559017,
0.0048970794,
-0.0059016086,
-0.0025338603,
0.013664172,
0.020219369,
-0.024263242,
-0.010302863,
0.013078197,
0.003541609,
-0.0025773256,
0.020811783,
0.025525343,
-0.010264227,
0.0022279941,
-0.004124365,
-0.008029793,
0.011133531,
0.01486188,
0.0060593714,
0.014205072,
0.017270174,
-0.012653204,
-0.025976093,
0.005312414,
-0.012427828,
-0.0045203813,
-0.017720925,
-0.031063132,
-0.012344117,
-0.0064650467,
0.022305699,
-0.015364144,
0.016265646,
-0.0075790435,
0.007501772,
0.003416043,
0.031655546,
0.009575224,
-0.026053365,
0.020618604,
-0.002110477,
0.0070703398,
-0.020592848,
-0.009890748,
0.021893583,
-0.0117323855,
0.0027061114,
-0.012376314,
-0.0017289491,
0.012814186,
-0.0019285672,
-0.0035480484,
0.012878579,
0.023155684,
-0.011185045,
0.018455002,
0.009343409,
-0.012891457,
-0.022421606,
-0.023413256,
0.026864715,
-0.008532058,
0.013908865,
0.012704718,
-0.0073021543,
-0.024610965,
-0.026027607,
-0.015621716,
0.023902642,
0.018364852,
0.014256586,
-0.028384387,
0.011378224,
0.06954432,
-0.03788878,
0.028770745,
0.007012386,
0.0016049929,
0.004249931,
0.01522248,
-0.01741184,
0.026581386,
0.010450967,
-0.007347229,
-0.0013763981,
0.020966327,
0.0070188255,
0.0017015822,
-0.026401086,
0.026104879,
0.03379339,
0.0068449643,
-0.025293529,
-0.0065809535,
-0.0128657,
0.0076885116,
-0.02209964,
0.027611673,
0.0066260286,
0.02526777,
-0.013986137,
-0.01023203,
-0.0079525225,
-0.008229412,
-0.026761686,
-0.0054669566,
-0.0062750876,
-0.0010729466,
-0.0044431095,
0.0043078847,
-0.006780572,
-0.0148876365,
-0.013947501,
-0.0022408727,
-0.014166436,
-0.000035743087,
-0.024211727,
-0.012923653,
-0.0018545153,
-0.0019688127,
0.0076305578,
-0.012814186,
-0.023645071,
-0.02037391,
-0.028332872,
0.0020154975,
0.025937457,
-0.016961088,
0.010051731,
0.011700189,
-0.00933697,
-0.016909573,
0.03253129,
0.0002716575,
-0.020695876,
-0.000043540662,
-0.022782207,
-0.006056152,
0.039743293,
-0.00049341057,
0.03389642,
-0.0022891674,
-0.0010560434,
0.01141686,
-0.006294405,
0.0059273657,
-0.022537513,
-0.014398251,
-0.0023149245,
0.008976369,
-0.024211727,
0.031861603,
-0.007476015,
0.014385372,
0.01640731,
0.0011880489,
0.003995579,
0.0020154975,
0.01884136,
-0.0016251156,
-0.0015663571,
-0.001187244,
-0.012511539,
0.025229136,
0.015093694,
0.03490095,
-0.004768294,
-0.002754406,
-0.018867118,
0.022898113,
-0.026761686,
0.02246024,
-0.01975574,
0.0034868752,
0.0009015005,
0.00534461,
-0.03361309,
0.0051063565,
-0.008557815,
0.0019253475,
0.036008507,
-0.009143791,
0.0022988264,
-0.013026683,
0.020451182,
-0.0038893307,
0.005537789,
0.021648891,
-0.016046708,
-0.03325249,
0.009465755,
-0.012485782,
0.020786026,
0.023129927,
-0.008506301,
0.00021672233,
0.018467883,
0.0018464662,
0.02528065,
0.014372494,
0.005911268,
-0.029337402,
-0.01884136,
0.018416367,
-0.0041919774,
0.00969113,
0.002038035,
0.02256327,
-0.020515576,
0.0035738056,
-0.008332441,
0.039923593,
-0.0002954024,
-0.012839943,
0.002137844,
0.0018335877,
0.011346028,
0.0064489483,
-0.013986137,
0.0072506396,
-0.0105282385,
0.006358798,
0.018802725,
0.033870663,
0.030470718,
0.026941987,
-0.001930177,
-0.00019317868,
-0.00081698486,
0.0014850611,
-0.008957052,
-0.010856641,
-0.0072442004,
-0.019614074,
-0.026761686,
-0.0072248825,
0.017566381,
0.0135869,
-0.01649746,
0.014501279,
0.015750501,
0.0095301485,
0.0057567246,
0.014552793,
0.020309519,
-0.003506193,
-0.0010037242,
-0.010779371,
0.028255602,
-0.009819916,
-0.028564688,
-0.015608837,
-0.0009336969,
-0.0020766708,
0.008725237,
-0.0073343506,
-0.0125051,
-0.015930802,
-0.024353392,
-0.021043597,
0.0024356612,
0.022949627,
0.0020975985,
-0.01024491,
-0.012382753,
0.017437596,
-0.025744278,
-0.024121577,
-0.018725453,
0.030676775,
0.0112751955,
-0.020734511,
-0.0055667656,
-0.015711866,
-0.028126815,
0.005399344,
-0.030393446,
-0.013155468,
-0.0023728781,
0.022537513,
0.00815214,
-0.0111528495,
0.03760545,
0.031861603,
-0.0034900948,
0.009015005,
-0.025770037,
-0.008622209,
0.0052705584,
0.076550275,
0.012389192,
0.009221062,
0.03273735,
0.008680162,
-0.001875443,
0.0028236283,
-0.022176912,
0.019897403,
0.015917923,
-0.009768402,
0.032196447,
0.018042888,
0.009143791,
0.0051256744,
0.02265342,
0.0013755931,
-0.013548264,
-0.009285456,
-0.0049067386,
0.0020798903,
-0.031011617,
0.0284359,
0.037579693,
-0.015415658,
0.008596451,
0.0075275293,
0.018326217,
0.0038732325,
-0.01729593,
0.0031133965,
0.0033838465,
-0.0054283207,
0.035905477,
-0.021236775,
0.016175495,
0.014089165,
0.010515359,
0.028126815,
-0.004005238,
0.0051321136,
0.0031858385,
-0.00416944,
0.002699672,
0.016059587,
-0.0019784716,
-0.010212713,
0.015286873,
0.010521798,
0.008165019,
0.0051417723,
-0.021970855,
-0.028229844,
-0.008654404,
0.01729593,
0.0017563162,
-0.0018738332,
0.021584498,
0.004919617,
-0.012885018,
-0.01612398,
-0.015879288,
0.014037651,
-0.01694821,
-0.00096347864,
-0.018867118,
-0.0013401771,
-0.0019704225,
-0.010341499,
0.0025081031,
0.022357212,
-0.03840392,
0.000028926495,
0.012498661,
0.0069286753,
-0.008184337,
0.0032196448,
0.015724745,
-0.00039199175,
-0.0022231645,
0.00978772,
-0.011017624,
-0.01793986,
-0.025435193,
0.01104982,
-0.01096611,
-0.01540278,
-0.024791263,
-0.02391552,
0.04221598,
-0.009826356,
-0.007083218,
-0.0084934225,
-0.008300244,
-0.018068645,
0.03036769,
-0.00643285,
0.00046081163,
-0.004938935,
-0.001865784,
-0.004378717,
-0.014179315,
-0.02781773,
-0.009504391,
0.02546095,
-0.011371785,
0.00047006813,
-0.0075532864,
-0.011461935,
-0.041984167,
0.03871301,
-0.039743293,
0.01830046,
-0.0019108591,
0.0018722233,
0.007057461,
0.015969437,
-0.001695143,
0.020811783,
-0.014539915,
-0.0057663834,
0.0044076936,
0.02209964,
-0.003100518,
-0.03871301,
0.020219369,
0.009485073,
-0.00017486695,
-0.018223189,
-0.024894293,
0.026027607,
0.038249377,
0.0065809535,
-0.017592138,
-0.0060142963,
0.01711563,
-0.03144949,
-0.014385372,
-0.015660351,
-0.0036092217,
-0.0073021543,
0.0072377613,
0.0014166436,
-0.029491944,
0.032943405,
-0.028616201,
0.029491944,
-0.00079283747,
-0.009027883,
0.026632901,
0.0018158796,
-0.0046620453,
-0.013986137,
-0.00054572977,
-0.0027608452,
-0.015248237,
0.003461118,
-0.029517703,
0.025718521,
0.048140127,
0.010270666,
0.010766491,
0.018635303,
0.035055492,
0.008171458,
0.0029250472,
0.0047715134,
0.00851918,
-0.009356287,
0.005173969,
0.015557323,
0.008016915,
-0.016098224,
0.00067089347,
0.024443543,
0.010161199,
0.006036834,
-0.03271159,
-0.012389192,
-0.042550825,
-0.019601196,
-0.00012425816,
-0.013702808,
0.017076995,
-0.04077358,
0.001712851,
-0.0100710485,
-0.016188374,
0.02020649,
0.005924146,
0.00034248971,
0.013264936,
0.025216257,
-0.0013160298,
-0.004584774,
-0.019639833,
-0.01041877,
-0.026323814,
0.0024147334,
0.005260899,
0.024417786,
0.018699696,
-0.006632468,
-0.008165019,
-0.009066519,
0.026684415,
-0.025035957,
-0.012807746,
0.012208893,
-0.03822362,
-0.0031665205,
-0.0017112411,
-0.0026610363,
-0.026941987,
-0.019923162,
-0.00087654823,
-0.012794868,
0.015660351,
0.016291402,
-0.037476663,
-0.00906008,
-0.00065278297,
0.011577842,
-0.007566165,
0.015544444,
0.0063942145,
0.005544228,
-0.010161199,
-0.00924682,
-0.013960379,
0.010393013,
0.035107005,
-0.0029105588,
0.0009972849,
-0.007810858,
-0.0009650885,
0.0056054015,
-0.01612398,
-0.056768775,
0.0080362335,
0.028616201,
-0.0018834921,
0.019008782,
-0.02655563,
0.002873533,
0.018197432,
0.018377732,
-0.015080815,
0.011197924,
-0.009452877,
-0.03062526,
0.01966559,
-0.024546571,
0.031784333,
-0.020940568,
-0.03291765,
-0.025808671,
-0.01984589,
-0.0052126045,
-0.0029652927,
-0.0116486745,
0.014617187,
0.0027592354,
0.010032413,
0.019330747,
-0.007978279,
-0.004143683,
0.00797184,
0.0040792897,
0.029878302,
-0.025074592,
-0.0084097115,
0.026220785,
0.0020203271,
-0.0104445275,
0.000032196447,
-0.017347446,
-0.019279232,
-0.0029636829,
0.015711866,
0.015196723,
-0.009047202,
-0.024018548,
-0.014205072,
0.017012602,
-0.01531263,
-0.0059949784,
-0.016909573,
0.0130588785,
0.0061559607,
-0.012949411,
0.002817189,
0.020670118,
0.028693473,
0.0052641192,
0.010702099,
-0.02944043,
0.028822258,
-0.0259117,
0.002836507,
0.016291402,
0.008635087,
-0.009452877,
-0.0058951695,
-0.012369875,
-0.021545863,
0.021159505,
-0.009633177,
-0.03580245,
-0.0072763967,
-0.0014287173,
0.0034997538,
0.010096806,
0.015776258,
-0.003705811,
-0.0038667934,
0.01894439,
-0.022305699,
-0.0041984166,
0.049273442,
-0.014501279,
0.028487416,
0.017012602,
-0.022485998,
0.019356504,
-0.028796501,
0.027663186,
0.004832687,
-0.031552516,
0.0074695754,
-0.0016693857,
0.015608837,
-0.010341499,
0.011571403,
0.011146409,
-0.0028976803,
-0.004056752,
0.015608837,
-0.015273994,
0.0026207909,
0.008029793,
0.018480761,
0.012994486,
-0.00013281034,
-0.016536094,
-0.0046266294,
-0.0052641192,
-0.0044366703,
-0.015377023,
-0.010702099,
-0.010438088,
0.033587333,
0.02926013,
-0.018661061,
-0.0106505845,
0.00024167458,
-0.035828207,
-0.015917923,
0.00073528633,
0.029852545,
0.004964692,
0.037940294,
-0.0029749516,
0.010341499,
0.0065841735,
-0.0005392905,
-0.027431373,
-0.016896695,
0.020554211,
-0.018377732,
-0.012498661,
0.013664172,
-0.045976527,
0.012163818,
0.0025789354,
0.0049550333,
0.008770312,
0.033200976,
-0.010264227,
-0.017798197,
0.0062364517,
0.013290693,
-0.015750501,
0.00851918,
0.015917923,
-0.034669135,
0.02119814,
0.01640731,
0.0014303272,
-0.03441156,
0.0057663834,
-0.005779262,
0.011526328,
0.014166436,
-0.01141686,
-0.02247312,
0.004964692,
-0.037270606,
0.010547556,
0.020193612,
0.0061302036,
0.013960379,
-0.00969113,
0.00851274,
-0.015480052,
-0.0055474476,
-0.01204791,
-0.004404474,
0.008049112,
-0.012711157,
0.007894569,
-0.010669902,
-0.027379857,
-0.01105626,
-0.008776751,
-0.0068900394,
-0.011403982,
-0.009356287,
0.018094404,
-0.03423126,
-0.018905753,
0.012253968,
-0.0038571344,
-0.0049228366,
-0.016909573,
-0.011133531,
0.03660092,
-0.0005944269,
0.031501003,
-0.012402072,
0.010721417,
0.01858379,
0.0036381984,
-0.018918632,
-0.016922452,
0.035828207,
0.18370004,
-0.024147335,
0.0046652653,
0.0057953605,
-0.006677543,
-0.003580245,
0.026259422,
0.018017132,
-0.024572328,
0.00951083,
-0.016845182,
0.009465755,
-0.014282344,
0.0064682662,
-0.008796069,
-0.04159781,
-0.028538931,
0.0031520321,
-0.014552793,
0.033123706,
-0.03405096,
-0.006922236,
-0.011429738,
0.00226502,
0.009646055,
0.021983733,
-0.011906246,
0.012621007,
0.032093417,
0.0027560159,
0.009845673,
-0.004555797,
-0.011468374,
0.0065101213,
-0.022086762,
-0.0022972166,
-0.005550667,
-0.02871923,
0.01720578,
0.008860462,
0.01639443,
0.03206766,
-0.009143791,
-0.018506518,
0.03335552,
0.005154651,
-0.014011893,
-0.00020223393,
0.004059972,
-0.005463737,
-0.042808395,
-0.023503406,
0.015595959,
0.020644361,
-0.025422314,
0.014127801,
0.008731676,
0.008197215,
0.008216533,
-0.00014850611,
0.021352684,
0.022589026,
-0.022962505,
0.02246024,
-0.01711563,
0.015827773,
-0.0062042554,
-0.0034965342,
0.027276829,
-0.009942262,
-0.020129219,
0.009182426,
-0.011861171,
0.0054862746,
-0.014591429,
-0.0063652373,
0.037656963,
0.027843487,
0.042679608,
0.0072506396,
-0.004594433,
-0.0012476123,
-0.017875466,
-0.013921743,
-0.009233941,
-0.024778385,
0.018815603,
0.023503406,
-0.022164034,
0.023967035,
-0.0117710205,
0.0020396449,
-0.015814895,
-0.018158795,
-0.01685806,
0.022086762,
0.0059563424,
0.011133531,
-0.020219369,
-0.0016291402,
-0.0071733682,
0.06902918,
0.004378717,
-0.0021990172,
0.021983733,
-0.007321472,
-0.012241089,
0.012131621,
0.018274704,
-0.032376748,
0.01640731,
-0.007862372,
0.01024491,
-0.012517978,
0.029672245,
0.013638414,
-0.007192686,
-0.019408017,
0.01558308,
-0.002236043,
0.0075597255,
-0.02166177,
0.0016202861,
0.029002558,
-0.0060658106,
0.0017675849,
-0.019163325,
0.0050355243,
0.0069351145,
-0.042112954,
0.0076691937,
-0.013921743,
0.00552491,
-0.012962289,
-0.008821826,
-0.00317296,
0.0032325233,
-0.008190776,
-0.014359615,
0.022537513,
-0.025576858,
-0.00015997609,
0.00026099244,
-0.0007703,
0.011313831,
-0.017695166,
-0.000105040905,
0.0011518279,
-0.015209601,
-0.002012278,
-0.009098716,
0.012917214,
0.01123012,
-0.029955573,
0.02954346,
-0.03526155,
-0.012440707,
-0.008171458,
0.04123721,
0.022537513,
-0.0019108591,
0.0131425895,
0.02817833,
-0.024932928,
-0.0010584582,
0.013883107,
-0.1601065,
0.019408017,
0.0037573252,
0.006696861,
0.0060722497,
-0.00046805583,
0.010025973,
0.008010476,
-0.023439012,
0.004340081,
0.018789846,
-0.0016806545,
-0.042937182,
-0.017785316,
0.011629356,
0.010096806,
-0.044688668,
0.025873065,
0.007740026,
0.0038024003,
0.04049025,
-0.026104879,
0.018313339,
-0.01558308,
0.0032550606,
-0.004684583,
-0.019086054,
0.028229844,
-0.008454787,
0.0033291127,
-0.020644361,
-0.005924146,
0.028873773,
-0.012872139,
-0.012717596,
0.015802016,
-0.002292387,
-0.009974459,
-0.008023354,
0.011378224,
0.023529163,
0.006201036,
0.015531566,
0.015196723,
-0.008847583,
0.0091566695,
0.0058404356,
-0.01014832,
0.018480761,
-0.00036080144,
0.015879288,
0.007836615,
-0.0022440923,
0.0005747066,
0.008049112,
-0.018017132,
0.009980898,
0.0060336143,
0.0025258113,
-0.0028670935,
-0.02301402,
-0.012434267,
0.019459533,
-0.016201252,
0.018776968,
-0.016690638,
-0.013561144,
-0.014630065,
-0.035570633,
0.001367544,
-0.01830046,
-0.01349675,
0.009382045,
-0.02427612,
0.03577669,
-0.0028687033,
-0.004584774,
-0.0063652373,
-0.005119235,
0.0008314732,
0.012170257,
0.015698988,
0.0043980344,
-0.0080748685,
-0.0060110767,
0.001955934,
-0.019433776,
0.016961088,
-0.007849494,
-0.033200976,
-0.010489603,
-0.019343626,
-0.014424008,
-0.011886928,
0.01222821,
0.0148876365,
0.013084636,
-0.021494348,
0.0057116495,
-0.02101784,
0.01141686,
0.008313122,
-0.037013035,
0.016832301,
0.021301169,
0.019549683,
0.007321472,
-0.0008173873,
0.024958685,
0.031552516,
-0.020000434,
0.043375053,
0.012099424,
0.016381552,
-0.012968728,
0.027431373,
-0.019408017,
-0.00016068039,
0.00842903,
-0.031217674,
0.033329763,
-0.0145141585,
-0.01885424,
-0.01367705,
-0.0050129867,
-0.0054669566,
-0.14156133,
-0.013715686,
0.010431649,
0.008055551,
0.02119814,
-0.00028272506,
-0.016806545,
-0.008100626,
-0.008132823,
0.03008436,
-0.007128293,
-0.03278886,
0.009897187,
-0.02193222,
0.048268914,
-0.011822536,
-0.014011893,
-0.03181009,
0.005669794,
0.016961088,
-0.007965401,
-0.027766215,
-0.00083469285,
-0.037116062,
-0.009098716,
-0.0017418278,
-0.030547988,
-0.0025902041,
0.008963491,
0.0058887303,
-0.03425702,
0.0008612549,
0.009304773,
-0.01929211,
0.01186761,
-0.01747623,
-0.0070252647,
-0.01531263,
0.016445944,
-0.027663186,
-0.0052319225,
-0.014810366,
-0.0022634102,
-0.033664603,
0.010605509,
-0.023258712,
-0.011423299,
-0.014127801,
-0.0012210503,
-0.0058211177,
-0.022910992,
-0.012949411,
-0.029981332,
-0.021739041,
-0.0044366703,
-0.0016677759,
-0.017463353,
0.0019527145,
0.0053574885,
0.007083218,
-0.00462341,
-0.009079398,
-0.013000925,
0.03137222,
0.013870229,
-0.003760545,
-0.018802725,
0.0055152513,
0.009942262,
-0.021803433,
-0.018995903,
0.017656531,
-0.010644145,
0.029388916,
-0.017720925,
0.0074888933,
-0.02817833,
-0.023709463,
0.031088889,
-0.03884179,
-0.008615769,
-0.008222972,
0.03353582,
-0.039717536,
0.015415658,
0.016355796,
0.024765506,
-0.0074888933,
0.014578551,
-0.024546571,
0.027766215,
0.040361464,
0.0154285375,
-0.0035029734,
0.014784608,
0.018879997,
-0.0015414049,
0.0013063708,
-0.019820133,
0.025126107,
-0.022807963,
0.0052254833,
-0.032376748,
0.034282777,
0.008229412,
-0.0059756604,
-0.0047328775,
-0.0019993994,
-0.00024871755,
-0.021455713,
-0.0070896577,
0.009137352,
-0.016780788,
0.03459186,
0.029878302,
0.0058050193,
-0.009562344,
-0.025396558,
0.013239179,
0.02936316,
0.003063492,
0.024430664,
-0.007115415,
0.0069866288,
0.018596668,
-0.0040664114,
-0.006542318,
0.01712851,
-0.0054283207,
0.027148044,
-0.010592631,
-0.021211019,
0.005029085,
-0.015299751,
-0.00380562,
0.004926056,
0.018236067,
-0.009942262,
0.01729593,
0.008255169,
0.025976093,
0.04115994,
-0.02400567,
-0.027302587,
-0.012801307,
-0.03317522,
-0.0059692212,
-0.018107282,
-0.01711563,
0.024894293,
-0.00046725094,
0.0052061654,
0.03508125,
0.01603383,
-0.039485723,
-0.036523648,
0.0041790986,
-0.008776751,
0.00743094,
0.019562561,
0.0035319503,
-0.047702257,
-0.0006318553,
0.017553503,
0.015698988,
-0.011146409,
0.01621413,
-0.027534401,
-0.0028413364,
0.0040020184,
0.01123012,
-0.036626678,
0.002699672,
-0.012472903,
-0.016020952,
0.010579753,
-0.009723327,
-0.01876409,
-0.018364852,
0.021636013,
0.00059120724,
0.02193222,
0.024108699,
0.016188374,
-0.026607143,
0.037219092,
0.031063132,
0.011539207,
-0.016999723,
0.012009274,
-0.026233664,
0.01187405,
-0.026040485,
0.017798197,
0.013561144,
0.018983025,
-0.010888838,
0.018609546,
-0.008750994,
-0.0056794533,
-0.0067097396,
0.011333149,
0.002384147,
-0.008937733,
-0.0025467388,
-0.026504114,
-0.007012386,
-0.020361032,
-0.0127691105,
-0.043478083,
-0.023065533,
0.024701115,
0.002229604,
0.00056866976,
0.0051449924,
-0.004819808,
-0.026233664,
0.010740735,
0.0016331647,
-0.003615661,
-0.01014188,
0.015299751,
-0.0007409207,
0.028152574,
0.0037476665,
-0.015917923,
0.028281359,
0.023181442,
0.017334567,
-0.0072763967,
-0.0055474476,
-0.0038635735,
-0.011307392,
0.0024694675,
-0.03915088,
-0.020258004,
-0.02110799,
-0.043297783,
0.020335276,
0.024894293,
-0.0055764248,
0.048037097,
-0.003271159,
0.008345319,
-0.0033419912,
0.036291834,
0.023876885,
0.014849002,
0.0031198356,
0.002347121,
0.0152611155,
-0.0046620453,
-0.0046008723,
-0.014102044,
-0.01858379,
0.015080815,
0.018867118,
0.0014850611,
-0.008615769,
-0.006774132,
0.017811075,
0.018017132,
0.009581663,
0.018274704,
0.0022006272,
-0.018661061,
-0.015505808,
0.018789846,
-0.009646055,
0.020090582,
-0.014153558,
-0.010863082,
0.008422591,
-0.008029793,
-0.017733803,
0.027431373,
-0.0077979793,
0.0047521954,
0.012569493,
0.0105668735,
0.005045183,
-0.0051127956,
0.018081525,
-0.027251072,
-0.028487416,
-0.043065965,
-0.012382753,
0.0018255386,
0.011841853,
0.0061624
] |
Cigarette smoke is the leading cause of the development of various lung diseases including lung cancer through triggering oxidant stress and inflammatory responses which contributed to the lesions of normal human bronchial epithelial (NHBE) cell. Wedelolactone (WEL), a natural compound from Eclipta prostrata L., has been found to possess the inhibitive effects on the proliferation and growth of cancers. In the present study, we investigated the effects of WEL on NHBE cell injury induced by cigarette smoke extract (CSE) in vitro. It showed that the pretreatment WEL (2.5-20μ | [
-0.003127489,
0.0033126692,
0.009807696,
-0.026103558,
-0.024484945,
0.0021450047,
-0.021165418,
-0.0042900094,
-0.022399953,
0.0072083133,
-0.014238304,
0.00932074,
0.0020867072,
0.03355192,
-0.013874803,
0.04043788,
0.032043044,
-0.017022867,
-0.01687198,
0.015555142,
-0.025609745,
-0.013435856,
0.01267456,
0.0077569955,
-0.0080862045,
0.0016563346,
0.03094568,
-0.047076937,
-0.017214905,
-0.007407211,
0.0034378374,
0.011700649,
-0.011529186,
0.0073043327,
-0.005476535,
0.0003169926,
0.0073797763,
-0.0039950926,
0.010678728,
-0.004766677,
0.015952937,
0.0006819949,
0.0073523424,
0.0018346563,
-0.045074247,
0.025047345,
0.011275421,
-0.021302588,
0.0110628065,
0.017064018,
0.015870634,
0.015829483,
-0.0036178736,
-0.007126011,
-0.007516947,
-0.008504575,
0.02301722,
0.019491937,
0.027228357,
-0.014389193,
-0.022907484,
0.0049141357,
-0.027022602,
-0.0018192247,
-0.018929537,
0.01235221,
-0.019656543,
0.016858263,
-0.011440025,
0.0003450697,
0.045595497,
0.027434113,
-0.0041459803,
-0.0049552866,
0.00035921542,
-0.0007398637,
-0.043976884,
0.0034429813,
0.00945791,
-0.0005118177,
0.01980743,
-0.025088497,
-0.027900493,
0.029491672,
0.032262515,
-0.0004033672,
-0.02068532,
0.002721121,
-0.009128701,
-0.010294651,
0.0035458591,
0.00955393,
0.009156135,
0.013518159,
-0.039587427,
0.0112342695,
0.0048626964,
0.021179136,
-0.0058503244,
-0.040328145,
-0.0027708453,
-0.012427653,
-0.0013279825,
-0.009142418,
-0.029820882,
0.0074620787,
-0.010459255,
0.0097459685,
0.025705764,
-0.014444061,
-0.021755252,
0.039724596,
0.0074346447,
-0.02795536,
0.01500646,
-0.0246084,
0.009855705,
0.010459255,
-0.009951725,
-0.019121576,
0.004879843,
-0.004749531,
0.014594948,
-0.035664346,
0.01580205,
-0.023991132,
-0.02167295,
-0.0140737,
-0.0048455503,
-0.006230973,
0.0029680282,
-0.0064573046,
0.024690703,
-0.014553797,
-0.021892423,
0.01667994,
-0.008607453,
-0.03294837,
-0.010651294,
-0.0012791156,
0.00016417602,
0.025047345,
0.011446884,
-0.014389193,
-0.02045213,
0.031988177,
0.014910441,
0.02270173,
0.00029898898,
0.019587956,
0.0084016975,
-0.041672416,
0.013943388,
-0.013332979,
-0.0038784978,
0.032262515,
-0.011522328,
0.035472307,
-0.008497717,
-0.015582576,
0.008346829,
-0.041699853,
0.010246641,
0.005517686,
0.026830563,
0.035390005,
0.0328935,
-0.0034464104,
0.006659631,
0.019999469,
-0.0018740928,
0.029244764,
-0.034374945,
0.026899148,
0.009341315,
-0.0071877376,
-0.0020901365,
0.035582043,
0.013339837,
-0.02470442,
-0.017914476,
0.03835289,
0.020630453,
-0.015294518,
-0.0074689374,
-0.018463159,
0.0141834365,
-0.0035149958,
-0.008580019,
-0.03286607,
-0.019039275,
0.032783765,
-0.016090108,
-0.03448468,
-0.6246199,
-0.023003504,
-0.0004603787,
0.01137144,
0.006268695,
0.0036521663,
0.024676984,
-0.00006135168,
-0.025417706,
0.017160038,
0.005479964,
0.010761031,
0.019546805,
0.028092531,
-0.0014282885,
-0.024169454,
-0.021398608,
-0.01780474,
0.029820882,
-0.006553324,
-0.006872245,
0.007866732,
-0.0410963,
0.017406944,
0.024087152,
0.03201561,
-0.002018122,
-0.017502964,
0.0029423086,
0.031576663,
-0.0070299916,
0.03174127,
-0.007955893,
0.021165418,
0.059861235,
0.0058057443,
-0.025623461,
0.010658153,
0.032180216,
0.014293173,
-0.02190614,
-0.012798014,
-0.0048112576,
-0.03774934,
-0.013765066,
0.01667994,
0.042577744,
0.010891343,
-0.009142418,
-0.008662322,
0.02068532,
-0.0028857258,
-0.00451977,
0.022454822,
0.010370094,
0.008689756,
0.023771659,
-0.026789412,
0.0010330658,
0.013236959,
-0.0011573767,
0.02777704,
-0.008662322,
-0.018504309,
-0.014677251,
0.002031839,
-0.009979159,
0.0114057325,
-0.0060800854,
-0.0019323904,
0.011344005,
0.035197966,
-0.0065156016,
-0.0004920994,
0.027653586,
0.03733783,
0.0031926448,
-0.005582842,
0.00072443206,
0.011830961,
0.012201322,
-0.012990053,
-0.036926318,
0.012317916,
0.01971141,
-0.028860686,
-0.009286447,
-0.01034952,
-0.00498615,
0.0019701123,
0.03821572,
0.016721092,
0.004087683,
-0.031988177,
-0.01710517,
0.0102054905,
-0.00090189645,
0.017681286,
0.0017986491,
-0.019889733,
-0.018668914,
-0.0040808246,
-0.011323431,
-0.01589807,
0.016240995,
0.030122656,
-0.03788651,
-0.03149436,
0.03267403,
-0.03541744,
0.007674693,
0.011563479,
-0.023264129,
-0.01360732,
-0.003947083,
-0.019190162,
0.0072151716,
0.005315359,
0.0006249834,
-0.04035558,
0.035911255,
0.014046266,
-0.0020009757,
-0.006230973,
0.00012409649,
0.00866918,
-0.012105302,
-0.002875438,
0.0034138325,
-0.01836714,
0.028915556,
-0.014581231,
0.030781075,
-0.008237093,
0.012201322,
-0.008058771,
0.021549495,
-0.013415282,
-0.0070299916,
-0.012667702,
-0.03267403,
0.0048524085,
0.008586877,
-0.0006661346,
-0.011042231,
0.004063678,
-0.020507,
0.014444061,
-0.011632064,
0.013819935,
-0.01006832,
-0.02595267,
-0.0281474,
0.028010229,
0.03308554,
0.009485344,
0.002997177,
-0.023058372,
-0.014114851,
-0.011446884,
0.0012379644,
0.013072355,
-0.01262655,
0.0009404757,
0.0026199578,
-0.011145108,
-0.003700176,
0.0062344023,
0.013915954,
-0.04543089,
0.0023404728,
-0.030808508,
0.0037378978,
0.029766012,
-0.0019101001,
0.0029954622,
-0.010630718,
-0.02021894,
-0.014910441,
0.0053805155,
0.0030314694,
-0.0062344023,
0.015088762,
-0.001652048,
-0.0096019395,
0.01947822,
0.039313085,
0.0068002306,
-0.0005576841,
0.024128303,
-0.014553797,
0.003014323,
0.0038133417,
0.03602099,
0.010130046,
-0.01813395,
0.034539547,
0.009005248,
0.01253739,
0.034594417,
-0.008483999,
-0.01747553,
0.008065629,
-0.025239384,
0.014759553,
-0.021522062,
-0.015719747,
-0.004557492,
0.02777704,
0.0151847815,
-0.000060601527,
0.009691101,
-0.022194197,
0.026707109,
-0.0063578556,
0.027530132,
-0.0066184797,
-0.0099723,
0.013696481,
-0.015692312,
-0.012249332,
-0.01827112,
0.012269907,
-0.018422008,
-0.039477687,
0.029464237,
0.0056034178,
0.007715844,
-0.008826926,
-0.017132604,
0.0031892157,
-0.017146321,
0.0062344023,
0.0007677265,
-0.030698773,
0.005346223,
0.010370094,
-0.019656543,
0.022468539,
0.011632064,
-0.0051027453,
0.026364183,
0.006179534,
-0.0025342263,
0.02237252,
0.004584926,
0.02530797,
0.0062515484,
0.008483999,
0.01537682,
0.0033435326,
0.020122921,
-0.011988708,
-0.000044660806,
-0.0038236296,
-0.024018565,
-0.002460497,
0.042605177,
0.0316864,
0.007242606,
0.033058107,
-0.016803395,
0.01006832,
-0.013058638,
-0.0012705424,
0.010130046,
-0.0036590248,
-0.0012199607,
-0.004739243,
-0.010507265,
-0.014485212,
0.004910706,
0.007647259,
-0.045540627,
0.03314041,
0.007564957,
0.010589568,
0.028366873,
0.00903954,
0.032646596,
-0.010925636,
0.0042145657,
0.027091186,
0.030589037,
-0.024416361,
-0.010767889,
-0.03555461,
0.0075375224,
0.0067865136,
0.030424431,
0.010239783,
0.02204331,
0.006025217,
0.011686932,
-0.011344005,
-0.020575585,
-0.009677383,
-0.0056651444,
0.03179614,
0.0040019513,
0.010061461,
-0.005994354,
-0.0145263625,
0.0039265077,
0.031878438,
0.0022873192,
-0.0052467743,
-0.0038716393,
0.0022238777,
-0.0019101001,
-0.014334324,
-0.0050684526,
-0.001323696,
-0.02367564,
-0.010843333,
0.0258155,
0.0051370375,
-0.018956972,
0.01924503,
-0.023799093,
-0.0000017263532,
-0.029985486,
-0.0006044078,
-0.01644675,
0.027159773,
0.005270779,
0.010136905,
0.0026336748,
0.023318997,
0.0020164072,
-0.000025250636,
-0.02301722,
-0.00932074,
0.016707376,
-0.003350391,
-0.024663268,
0.03015009,
0.02307209,
0.014430343,
-0.0073180497,
-0.00950592,
-0.019876014,
-0.0103769535,
-0.010863909,
0.0032355108,
0.00081830815,
0.02004062,
0.039669726,
0.011350865,
0.0084291315,
0.013058638,
0.0140737,
0.0026713968,
0.0063647144,
-0.0011916693,
0.008607453,
-0.0002334043,
0.033030674,
0.024526097,
0.008874936,
-0.005994354,
0.0053427937,
0.014690967,
-0.0060595097,
0.008861219,
0.01667994,
-0.0007823009,
-0.0013245533,
0.004358595,
-0.012647126,
0.024484945,
0.0070642843,
-0.01547284,
-0.01821625,
0.021494627,
-0.024553532,
-0.010164339,
-0.050067257,
0.011988708,
0.0049278527,
0.014649817,
0.0036281615,
-0.01840829,
0.0038476344,
0.004866126,
-0.026789412,
0.0107747475,
-0.0011616632,
-0.0011822388,
-0.00347213,
-0.016597638,
-0.0003103484,
-0.0019135294,
-0.0029560258,
0.008099922,
-0.013332979,
-0.034923624,
0.013504442,
0.033661656,
0.021522062,
0.021192852,
-0.0056137056,
-0.011810386,
0.014910441,
0.00044151777,
0.011590913,
-0.000595406,
-0.03196074,
-0.0064881677,
0.0069408305,
0.0047735358,
-0.016666224,
-0.034347508,
0.0075923908,
0.0018432295,
-0.012791155,
0.011124533,
-0.024594683,
0.0034978495,
0.011933839,
0.010123188,
0.03560948,
-0.0016434748,
0.008127356,
-0.004495765,
-0.012482521,
-0.0070197037,
0.0015217359,
0.014238304,
-0.0021209999,
0.0037961954,
-0.0011899547,
-0.017297208,
0.009149277,
0.017695002,
-0.006608192,
0.0034138325,
0.0077432785,
0.007530664,
0.030396998,
-0.0217141,
0.0075100884,
-0.0019358196,
-0.004358595,
0.006762509,
0.0011213694,
0.02781819,
-0.008127356,
-0.029848315,
-0.0049518575,
-0.017502964,
-0.016282147,
-0.021782685,
0.011433166,
0.0148418555,
0.009841988,
0.008682896,
-0.046720296,
-0.035993557,
0.015994089,
-0.015047611,
0.0037859075,
-0.034786455,
-0.026569938,
-0.0064847386,
-0.007119152,
-0.008545727,
-0.018668914,
0.02530797,
-0.0281474,
-0.0036178736,
0.021069398,
-0.016707376,
0.0018260832,
-0.022495972,
-0.0066459137,
-0.019066708,
-0.00727004,
-0.007715844,
-0.03248199,
-0.02763987,
-0.00068585284,
0.0117418,
0.017873324,
0.024992477,
0.0002882725,
0.04186446,
-0.011899547,
-0.005997783,
-0.0055382615,
-0.013621037,
0.021330023,
-0.014087417,
0.029354502,
0.026034974,
-0.0000799983,
0.010911918,
0.012084727,
-0.019985752,
0.020026902,
-0.011488035,
-0.009101267,
-0.012283624,
-0.0069408305,
-0.030671338,
0.022070743,
-0.013168374,
-0.0068070893,
-0.034237772,
-0.007976469,
0.0055073984,
0.013003769,
-0.016007805,
-0.019491937,
-0.001435147,
-0.03508823,
0.026583655,
-0.010294651,
-0.013525018,
-0.012619692,
-0.028449176,
0.007846156,
-0.026391616,
0.0095470715,
-0.0065361774,
0.016295863,
0.014142285,
-0.018764934,
-0.012900892,
0.008223375,
-0.001437719,
-0.004763248,
-0.028229702,
-0.030918246,
-0.0006644199,
-0.008593736,
-0.0030331842,
-0.032399688,
0.012743145,
-0.0131820915,
-0.0067316457,
0.03034213,
-0.016940566,
-0.024622116,
0.0052742083,
-0.012084727,
0.033524487,
-0.020849926,
0.036514804,
0.04449813,
-0.015856918,
-0.010802182,
0.011542903,
-0.00703685,
-0.0026456772,
0.006062939,
0.009663667,
-0.023195542,
0.0066321967,
-0.0061966805,
0.027228357,
-0.009725393,
-0.00698884,
0.023648206,
0.008689756,
0.010418104,
-0.021000814,
-0.011515469,
-0.012009283,
0.0074552204,
-0.022715446,
-0.00095933664,
-0.024471229,
-0.024567248,
-0.0023644776,
0.0065910458,
-0.013483867,
0.020438414,
-0.00007994472,
0.00047323844,
-0.0151847815,
-0.016899414,
-0.038380325,
0.026240729,
0.0023833385,
0.029327067,
-0.011398874,
-0.004180273,
0.010644436,
-0.012605975,
0.009142418,
0.0074552204,
-0.0067830845,
0.033634223,
0.00093275984,
0.019725127,
0.03596612,
-0.022674294,
0.027845625,
-0.0074620787,
-0.014197154,
-0.011302855,
-0.01290775,
-0.0052227695,
0.01780474,
0.015033894,
-0.024827871,
-0.0048009697,
-0.020863643,
-0.0053976616,
-0.023881396,
-0.013662188,
0.0041014,
-0.043510504,
-0.006282412,
0.0018072223,
-0.007530664,
0.032509424,
0.010754173,
-0.013648471,
-0.0014240019,
0.027735889,
-0.010157481,
0.015939219,
0.0030177524,
0.008607453,
-0.006333851,
-0.007050567,
-0.017955627,
-0.04822917,
-0.017791022,
-0.0061212364,
-0.037036054,
-0.031000547,
-0.026652241,
-0.0151847815,
0.010726738,
-0.02167295,
0.03442981,
0.00783244,
0.027104903,
-0.0046912334,
-0.0115771955,
0.012612834,
-0.014402909,
0.0073797763,
0.051109754,
-0.008566302,
-0.0351431,
0.004756389,
-0.001684626,
-0.00727004,
-0.0058503244,
0.004763248,
-0.025788067,
0.013531877,
0.006573899,
-0.0023970557,
-0.010466115,
0.004454614,
-0.017132604,
0.03421034,
-0.009005248,
-0.014101134,
0.011337147,
-0.003336674,
-0.01454008,
0.014114851,
-0.050176993,
-0.0054216664,
-0.0130106285,
-0.011926981,
-0.032783765,
-0.013250677,
0.011007938,
0.01957424,
0.0040808246,
-0.008333112,
-0.032591727,
-0.006813948,
-0.038791835,
-0.016433034,
-0.016789677,
0.008285102,
-0.018655198,
-0.0036315906,
-0.011199976,
0.027557567,
-0.013806217,
-0.0095470715,
-0.01794191,
-0.016693657,
0.027585002,
-0.044717606,
0.02148091,
0.0031120572,
-0.036240462,
-0.0018329417,
0.03182357,
-0.0016863407,
-0.025733199,
0.014965309,
-0.0065498943,
-0.017448096,
-0.010445539,
0.005167901,
-0.015939219,
0.014128569,
-0.012132737,
-0.017695002,
0.014649817,
0.007311191,
0.014677251,
-0.022454822,
0.008730906,
0.012640268,
-0.0032355108,
0.00082259474,
-0.003830488,
-0.04315386,
-0.0022084462,
-0.016021522,
0.009519638,
0.0051233205,
-0.008504575,
0.04968318,
-0.0125785405,
-0.016570205,
-0.025774349,
-0.01510248,
0.00016642647,
-0.007023133,
0.016487902,
-0.015321952,
-0.034594417,
0.019231314,
0.0012765436,
-0.03196074,
-0.005027301,
-0.026254447,
0.015815767,
-0.0007994472,
0.03242712,
0.0087446235,
-0.00011905976,
-0.022454822,
0.012009283,
-0.00018539459,
-0.007901025,
-0.007228889,
0.020287527,
-0.027091186,
0.00026791127,
-0.0029800306,
-0.015321952,
0.0152122155,
0.0009301879,
-0.023442449,
0.008456565,
0.0006914254,
0.20465848,
0.008285102,
-0.011227411,
0.0316864,
0.023099523,
-0.016090108,
0.020301243,
-0.006021788,
-0.026391616,
-0.0045506335,
0.016090108,
-0.010836475,
-0.02721464,
0.009121843,
0.010452397,
0.0059257685,
-0.03242712,
0.0003457127,
-0.0031377766,
0.00046637992,
0.0042145657,
0.002167295,
0.019917166,
0.00122339,
0.021919856,
0.008874936,
-0.017064018,
-0.0017180613,
0.024663268,
0.002026695,
-0.020150356,
0.013161516,
0.0028788673,
0.0027245504,
0.0034412665,
-0.020383546,
-0.0027982795,
-0.0030983402,
0.025788067,
0.022386236,
0.018710066,
-0.016501619,
-0.025664613,
-0.003854493,
-0.011241128,
0.004358595,
-0.005747447,
-0.01901184,
0.017297208,
-0.009080691,
-0.023003504,
0.021727817,
0.023703074,
0.021275155,
0.0032372253,
0.015239649,
0.020328678,
-0.002172439,
-0.0063509974,
0.010082036,
-0.01836714,
0.009526496,
0.0012405363,
0.0055245445,
-0.026350467,
0.005586271,
-0.021083117,
-0.0062138266,
0.0020867072,
0.0035527176,
0.013031203,
-0.025554877,
-0.028339438,
0.006724787,
-0.01570603,
-0.018092798,
0.008634887,
0.0015157347,
0.008628028,
0.022550842,
-0.0015688883,
-0.004608931,
-0.041535247,
0.002585665,
-0.018902104,
-0.017640134,
0.0062378314,
0.012640268,
-0.042303402,
-0.002390197,
0.0010244927,
0.007811864,
-0.0076541174,
0.0016923419,
0.04386715,
-0.0037687612,
-0.015582576,
0.00030713348,
-0.02274288,
0.008038195,
-0.009114984,
0.06770739,
-0.0049587158,
0.0012491095,
0.0013271252,
0.03286607,
0.008861219,
0.002525653,
0.0022255925,
0.0038373466,
-0.0018123661,
-0.035060797,
-0.006008071,
-0.015870634,
-0.0060697976,
0.0066459137,
0.01398454,
-0.021851271,
0.0004278007,
-0.036761712,
0.005047877,
-0.0115771955,
0.012530531,
0.03983433,
0.011680074,
0.013387847,
-0.034649286,
-0.00092590135,
-0.016981715,
-0.039669726,
0.011680074,
-0.012667702,
-0.0059291977,
0.0096019395,
0.029327067,
-0.0010142048,
0.0125854,
-0.010198631,
0.010568992,
0.018696347,
-0.016734809,
-0.0019958317,
0.021631798,
0.018325988,
0.019286182,
-0.015719747,
-0.0023696215,
-0.0070848595,
-0.00014692254,
-0.00787359,
-0.019354766,
-0.016556486,
-0.0021501486,
-0.017448096,
0.037776772,
-0.011899547,
-0.016254712,
-0.011776093,
0.021837555,
0.0028908697,
-0.017077735,
0.002973172,
0.011446884,
-0.02875095,
0.0026868284,
0.006423012,
-0.17524911,
0.03179614,
0.02093223,
-0.024046,
0.013813076,
0.020479565,
0.014444061,
0.013669047,
-0.03308554,
0.006700782,
0.021467194,
-0.0027245504,
-0.035691783,
-0.0094030425,
-0.005411379,
-0.016391883,
0.030726207,
0.026336748,
0.016090108,
0.012221897,
0.024923893,
-0.020205224,
0.0077707125,
-0.02367564,
-0.005130179,
0.0023970557,
0.0066287676,
0.0024124873,
-0.00090789766,
0.008922946,
-0.02307209,
0.021988442,
0.01691313,
-0.0072151716,
0.00025312256,
0.015198499,
-0.005579413,
-0.028119966,
-0.0030297549,
0.011001079,
0.032235082,
0.033579353,
0.004931282,
0.012605975,
-0.035499744,
0.041644983,
0.01393653,
0.0008058771,
0.030561602,
-0.016487902,
0.036789145,
-0.022331368,
0.006100661,
0.023661923,
0.0065258895,
0.014252022,
0.012324776,
0.005143896,
-0.013003769,
-0.017352076,
-0.0056171347,
-0.035060797,
-0.0011796668,
0.0024159166,
0.016707376,
-0.013991398,
-0.019738844,
0.008559443,
-0.02036983,
0.01137144,
-0.027091186,
-0.017187472,
0.014512646,
-0.014046266,
0.03714579,
-0.003149779,
-0.002357619,
0.0019941172,
-0.010315226,
0.012263048,
-0.012557966,
0.0058709,
-0.006968265,
0.0001802507,
-0.013003769,
0.009238438,
0.00036628827,
0.0072906157,
-0.01780474,
0.009211004,
0.02367564,
-0.020328678,
-0.0069099674,
-0.040931698,
0.010809041,
0.014800704,
0.016240995,
0.013168374,
0.0035801518,
0.004156268,
0.027365528,
-0.02134374,
-0.023181826,
0.017832173,
0.02563718,
0.006813948,
-0.019738844,
-0.001568031,
0.03983433,
-0.0217141,
-0.015116196,
0.008840643,
0.0062241144,
0.028696083,
-0.003936795,
0.007386635,
-0.007955893,
-0.004207707,
0.005857183,
-0.030424431,
0.05149383,
0.01141945,
-0.0015294518,
0.0039676586,
-0.008593736,
-0.011247986,
-0.108968295,
-0.028202267,
-0.0071877376,
0.02069904,
-0.022797748,
0.029354502,
-0.023703074,
0.03920335,
0.006062939,
0.038462628,
0.0040979707,
0.010260358,
-0.010562134,
0.006546465,
0.028778385,
-0.0006759937,
0.01747553,
0.005301642,
-0.019327333,
0.036789145,
-0.0067042112,
-0.021124268,
-0.015692312,
-0.026528787,
-0.0001699629,
-0.017379511,
-0.019587956,
0.028023947,
0.008532009,
0.013236959,
0.010815899,
-0.00019525373,
0.021234004,
0.014279456,
-0.011878971,
-0.016337015,
0.0058366074,
-0.013326121,
0.03248199,
-0.019135294,
0.0148418555,
0.0077432785,
0.021028249,
-0.012640268,
-0.0060938024,
-0.015020177,
-0.018147666,
0.019533088,
0.011282279,
0.001139373,
-0.009992876,
-0.02218048,
-0.016460467,
0.005318789,
0.028010229,
0.0028771525,
0.0046432237,
0.014046266,
-0.018339705,
-0.0025290824,
0.005709725,
0.0037104639,
-0.017132604,
-0.023181826,
0.031933308,
-0.019766279,
-0.0067659384,
-0.0060595097,
0.0055348324,
-0.023840245,
-0.013099789,
-0.013792501,
-0.022674294,
0.027146054,
-0.021563213,
0.0052296277,
-0.029519105,
-0.019080427,
0.0011950985,
-0.028888121,
0.0022015877,
-0.014032549,
0.016583921,
-0.019683976,
0.032591727,
0.01566488,
-0.00037807637,
0.002302751,
-0.008929804,
-0.036185596,
-0.026323032,
0.017173754,
0.009430476,
-0.015225933,
0.0009910574,
-0.0058743292,
-0.03580152,
-0.011055947,
0.029848315,
0.012269907,
-0.008175366,
-0.042852085,
-0.06309846,
0.015267084,
-0.015459123,
0.019149011,
-0.00783244,
-0.006608192,
0.016090108,
0.016021522,
0.0073249084,
0.017557831,
-0.014732119,
0.039258216,
0.0068208063,
-0.028366873,
-0.017406944,
-0.0070780013,
0.009622515,
0.020109205,
-0.0057440177,
0.01454008,
0.0037207515,
-0.024457512,
0.0087446235,
0.013847369,
-0.0398069,
-0.010150622,
0.0057885977,
-0.008003903,
-0.0031103427,
-0.004591785,
0.01598037,
-0.020987097,
-0.0115497615,
-0.0034584128,
-0.0066664894,
-0.023456167,
-0.01547284,
0.03220765,
0.010363236,
0.015541425,
-0.0076061077,
-0.027996512,
-0.006491597,
0.019052992,
0.00517133,
-0.0045231995,
-0.02204331,
0.024855306,
0.017173754,
0.020657888,
0.024320342,
-0.0016417602,
0.0069648353,
-0.024869023,
-0.002642248,
0.0022290216,
0.0040979707,
-0.01393653,
0.0049758623,
-0.016487902,
0.0056514274,
0.028915556,
0.013477008,
0.00070085586,
0.002162151,
-0.0065396065,
0.0009516208,
-0.015856918,
0.005185047,
-0.0114606,
-0.0038099124,
-0.01477327,
-0.0042591463,
0.0030503306,
-0.0073934933,
-0.012427653,
-0.012592258,
-0.010239783,
-0.01039067,
0.02297607,
0.008847501,
-0.019025557,
-0.018627763,
0.008957238,
0.007167162,
0.0061966805,
-0.02740668,
0.014800704,
0.016803395,
-0.0006391291,
0.008291961,
0.004478619,
-0.0029131598,
0.0048146867,
0.002455353,
0.01113825,
0.010013451,
-0.013545593,
0.015033894,
0.018490592,
0.005075311,
0.0034224056,
0.0038133417,
-0.00021775828,
-0.00029663136,
0.00024240611,
-0.018024212,
-0.013195808,
-0.018586611,
0.022057027,
0.009245296,
-0.000017561582,
0.01454008,
0.0009464769,
-0.007516947,
0.021165418,
-0.011693791,
0.00521934,
-0.017969344,
0.050067257,
0.008525151,
0.03127489,
0.018586611,
0.018737499,
0.02167295,
-0.008017619,
0.024718136,
-0.0016829114,
0.015431688,
-0.011069665,
0.016323298,
-0.009080691,
-0.05656914,
-0.007894166,
-0.006443587,
0.017928192,
0.031768702,
0.010315226,
-0.02940937,
0.092946775,
0.025568593,
-0.039230783,
0.025733199,
-0.012592258,
0.025856651,
0.007139728,
0.014732119,
0.0035664346,
-0.031713836,
0.008010761,
-0.021398608,
0.017516682,
-0.027735889,
-0.028366873,
-0.00773642,
0.0056582857,
0.009382467,
0.010335802,
-0.004022527,
0.03695375,
0.007009416,
0.005438813,
0.027653586,
-0.031055417,
-0.022591991,
0.029189896,
-0.008868077,
-0.0037721905,
-0.027324377,
-0.01537682,
0.022153046,
-0.013147798,
-0.013504442,
0.010980504,
-0.019546805,
0.0025427993,
-0.01891582,
0.0008607453,
0.0145263625,
-0.010541558,
0.020410981,
-0.027050035,
-0.030808508,
-0.010006593,
-0.0036007273,
-0.004502624,
0.009108125,
-0.035005927
] |
The role of immune responses in tumor development is a central issue for tumor biology and immunology. IL-17 is an important cytokine for inflammatory and autoimmune diseases. Although IL-17-producing cells are detected in cancer patients and tumor-bearing mice, the role of IL-17 in tumor development is controversial, and mechanisms remain to be fully elucidated. In the current study, we found that the development of tumors was inhibited in IL-17R-deficient mice. A defect in IFN-gammaR increased tumor growth, whereas tumor growth was inhibited in mice that were deficient in both IL-17R and IFN-gammaR compared | [
-0.027913505,
-0.004923632,
-0.0148613565,
-0.011404476,
-0.023894478,
-0.003870414,
-0.040448736,
0.00056416617,
-0.011759856,
-0.025225537,
0.019914217,
-0.019074228,
0.025083385,
-0.0011057173,
-0.012418925,
0.010945712,
0.044015463,
0.015559195,
-0.005317781,
0.02403663,
-0.026931362,
0.004409946,
0.0043905615,
-0.0018495928,
-0.008115593,
0.012871227,
0.010952174,
-0.07397079,
-0.009537114,
-0.005246705,
0.009905417,
-0.0026055835,
-0.00951773,
-0.0021985115,
-0.0076697525,
-0.025897529,
0.018983768,
-0.015119815,
0.0151844295,
-0.0100798765,
0.011501398,
0.0035473413,
-0.0077989814,
-0.0056666997,
-0.0047104037,
0.011294631,
0.012987534,
-0.020263137,
-0.021529583,
0.012031238,
0.0060091573,
-0.000020419222,
-0.030730702,
-0.020288983,
-0.041456725,
-0.006849147,
-0.0072691417,
0.0046651736,
0.011960162,
-0.023545558,
-0.0044939453,
-0.003306652,
-0.016786871,
-0.0016848255,
-0.004300101,
0.013982599,
-0.0041708723,
0.023067411,
-0.0023794326,
0.0097438805,
0.044325612,
0.050399385,
-0.024605237,
-0.0030578857,
0.0013787139,
-0.022124037,
-0.018764079,
0.006370999,
-0.022214498,
0.001877054,
0.025690762,
-0.025639072,
-0.0014942125,
0.017407171,
0.02585876,
0.013071532,
-0.0019222841,
0.009330347,
0.010441719,
-0.0067974553,
0.012612768,
0.0012809844,
0.0063903835,
0.035434645,
-0.009511269,
0.001602442,
0.015546272,
0.026181834,
0.000058052174,
-0.021103127,
0.0016169802,
0.0054050107,
0.0021468198,
-0.010738946,
-0.03054978,
-0.0023132025,
0.010325412,
0.010073415,
0.022162806,
-0.018609004,
-0.021271124,
0.030937469,
-0.005618239,
-0.02843042,
0.029386718,
-0.0009530653,
0.012160467,
0.022692645,
-0.0092980405,
0.0023261255,
0.021232355,
-0.0023923554,
0.025109231,
-0.008710047,
0.03471096,
0.00015356063,
0.0005104553,
-0.01620534,
-0.022460032,
-0.007042991,
0.018647771,
-0.0005310512,
0.01996591,
-0.001907746,
-0.0012906765,
0.008626048,
-0.009776188,
-0.015093969,
-0.009149427,
-0.023984937,
-0.0062934617,
0.021594198,
-0.0010847175,
0.0072368346,
0.012289695,
0.0013633679,
0.028482113,
0.0012268696,
0.0053565498,
0.008225438,
-0.021309894,
-0.032772522,
0.009685728,
-0.0038833371,
0.0131943,
-0.0037121084,
-0.013672448,
0.040526275,
-0.012664461,
-0.0016848255,
0.026698751,
-0.026543675,
0.02089636,
0.032617446,
0.01292938,
0.0144349,
0.016631797,
0.026957208,
-0.009543575,
0.010422334,
-0.0008173746,
0.03706293,
-0.0077149826,
0.027474126,
-0.032953445,
0.0108875595,
-0.009246348,
0.02664706,
-0.014913049,
-0.022421265,
-0.01686441,
0.022111114,
0.02682798,
0.0051207067,
-0.019268071,
-0.008341745,
0.04378285,
-0.005069015,
0.00014255595,
-0.0075469846,
0.019048382,
0.019629914,
0.004006105,
-0.0329276,
-0.63105196,
-0.014008444,
0.026621213,
0.015623809,
-0.012767844,
0.032462373,
-0.008109132,
-0.0035602641,
-0.033883892,
0.014602899,
-0.00832236,
0.009498346,
0.02071544,
-0.017639784,
-0.019901294,
-0.034374963,
-0.019203458,
-0.011055557,
-0.0067263795,
0.0013859831,
-0.0047717877,
0.0024149704,
0.0061028483,
0.008438666,
-0.01053864,
0.018298853,
0.0135949105,
-0.01004757,
0.008193131,
0.055310093,
-0.0063451533,
0.001709056,
-0.012567539,
0.015921036,
0.047840647,
0.019604068,
0.007934672,
0.033909738,
0.009181734,
0.04652251,
-0.010816483,
-0.007979902,
0.009821419,
-0.009194657,
-0.026143065,
0.016890256,
0.00956296,
0.0009046043,
0.004361485,
-0.024140013,
0.003776723,
0.016670566,
-0.019810835,
-0.00526932,
0.02925749,
-0.0037573387,
0.028171964,
-0.007185143,
0.009718035,
-0.019849604,
-0.005508394,
0.03830353,
-0.013439836,
-0.010932789,
-0.0017865936,
0.012845381,
-0.010118646,
-0.010906943,
0.0047394806,
0.016580105,
0.011475552,
0.026311062,
-0.0034827266,
-0.010583871,
0.01252877,
0.050399385,
-0.005705469,
0.011740472,
-0.0009974878,
0.009226964,
0.0088522,
-0.0077149826,
-0.016153648,
0.0162958,
0.01788532,
-0.008031595,
0.0013787139,
0.02160712,
-0.013530296,
0.018402237,
0.030162092,
-0.003028809,
-0.008658356,
-0.034736805,
-0.024256319,
0.021749273,
0.009459577,
0.012767844,
0.016709333,
-0.0038316455,
-0.018311776,
-0.0009950647,
0.0069783763,
-0.0025118925,
0.029800251,
0.016670566,
-0.033496205,
0.000953873,
0.042387173,
-0.023041565,
0.00748237,
0.020508673,
-0.006933146,
-0.0065002283,
0.01372414,
-0.008923275,
-0.009478961,
0.016954869,
0.019823758,
-0.012412463,
0.014667513,
-0.013349376,
0.032824215,
-0.0043097935,
0.012341388,
0.016786871,
-0.0048977863,
-0.011326939,
-0.008399897,
-0.030136246,
-0.0056731612,
-0.008083286,
0.010125107,
-0.028120272,
0.025522765,
0.01013803,
0.038536143,
0.0023519713,
-0.009556498,
-0.03509865,
-0.042516403,
-0.02540646,
0.008716509,
-0.005692546,
0.0032468834,
0.008115593,
-0.007979902,
-0.008270668,
0.029231643,
-0.0020402058,
0.0006986453,
-0.00030308284,
-0.011585397,
0.0029787328,
0.022628032,
0.0017025946,
-0.00043170626,
-0.0029965017,
0.011514321,
-0.016580105,
-0.010680793,
0.004923632,
0.016722256,
0.015378273,
-0.016386261,
-0.00000167531,
-0.0065454585,
0.010144492,
0.008089747,
-0.035874024,
-0.01221862,
0.0007475101,
-0.034142353,
0.009362655,
0.028352885,
-0.012767844,
-0.017613938,
-0.022666799,
-0.0041514877,
-0.0055859317,
-0.011294631,
-0.0041579492,
0.005595624,
0.0024795851,
0.022808952,
0.0017720553,
0.019203458,
0.01735548,
0.0035311875,
0.03985428,
-0.015753038,
0.016166572,
-0.009802034,
0.037786614,
0.017639784,
-0.02461816,
0.023868632,
0.0058153137,
-0.005831467,
0.021878501,
-0.020960974,
-0.024411393,
0.0012414079,
-0.030808238,
-0.00073539483,
-0.015778884,
0.009052505,
-0.01673518,
0.01394383,
-0.002939964,
0.0043937922,
0.007462986,
-0.011798625,
0.022343727,
0.008593741,
-0.0019190535,
0.004038412,
-0.007895904,
0.0063871527,
-0.033341132,
-0.008884506,
0.010215567,
0.002886657,
-0.029748559,
-0.0025910453,
0.0026637367,
0.018531466,
-0.006251462,
-0.0018867461,
-0.014447823,
-0.0135949105,
0.0063774604,
-0.012464155,
0.0018285931,
0.010112184,
0.0042774864,
0.0012688691,
-0.018040394,
0.039880127,
-0.010622639,
0.0049688625,
0.0020563595,
0.016399184,
0.011100788,
-0.0007790097,
-0.015158584,
0.037295543,
-0.0018609003,
-0.015171506,
0.027732585,
-0.026143065,
0.020198522,
-0.008380513,
0.0005892043,
-0.006894377,
-0.0128001515,
0.0023487406,
-0.002621737,
0.054793175,
0.006212693,
0.040758885,
-0.020133907,
0.0017445941,
-0.0020951282,
-0.021968963,
0.016954869,
-0.0033179594,
0.001009603,
0.016037343,
-0.0023584326,
-0.0490554,
0.0042128717,
0.016799795,
-0.031945456,
0.0023325868,
0.03148023,
0.023972014,
0.005211167,
0.01465459,
0.0164638,
0.008096209,
-0.011230016,
0.0344525,
0.014990586,
0.00022231459,
-0.005521317,
-0.013711217,
0.0016145572,
0.0054050107,
0.006674688,
0.0064743822,
0.025122155,
0.0041902564,
0.0164638,
0.0027041207,
0.006571304,
0.017833628,
-0.02843042,
0.006784532,
0.0065551507,
0.0066876104,
-0.017588092,
-0.023984937,
0.010131569,
0.016050266,
0.01713579,
0.006325769,
-0.02837873,
-0.03706293,
-0.0012543309,
-0.0029270411,
-0.013401067,
0.0006752225,
-0.0270089,
0.003870414,
0.007566369,
0.032694984,
0.0024989694,
0.024359703,
0.0020563595,
-0.019474838,
-0.037760768,
0.018376391,
-0.013336453,
0.023054488,
0.019216381,
0.005963927,
0.026491985,
0.015339505,
-0.0019319764,
-0.023972014,
-0.034374963,
0.013698294,
-0.04210287,
-0.01828593,
0.0067263795,
-0.0019271303,
0.0036248788,
-0.009730958,
0.027861813,
0.014848433,
-0.011895547,
0.0042484095,
0.0034116507,
0.00836759,
0.03248822,
0.03204884,
0.012328465,
0.03336698,
-0.0014045597,
-0.009091274,
0.007088221,
-0.009046043,
-0.034633424,
-0.011934316,
0.025277229,
-0.0094208075,
0.00916235,
0.00100718,
-0.023972014,
-0.00031075583,
0.008180208,
0.010745407,
0.0023972015,
0.01633457,
0.02182681,
0.012134621,
0.005724853,
-0.016502567,
-0.01372414,
0.0038122612,
0.011785702,
-0.0091235805,
-0.026595367,
0.014098904,
-0.02899903,
0.00872297,
-0.020340674,
0.018841615,
0.00055124325,
-0.0016274801,
-0.012987534,
-0.01332353,
0.0011614474,
0.005369473,
-0.02257634,
0.009407885,
0.010919866,
-0.0050657843,
-0.01744594,
0.007385448,
-0.009356193,
-0.026091373,
-0.013556142,
0.037786614,
-0.0270089,
0.0051691676,
0.004985016,
0.019190535,
0.017148713,
0.0052176286,
4.2277128e-7,
0.0036022638,
0.014796742,
0.00047653264,
-0.031351,
0.015429965,
-0.023765247,
0.015106892,
0.009007274,
0.008600202,
-0.007107605,
-0.033987276,
-0.012677384,
-0.0051853214,
-0.006180386,
0.0044971756,
-0.000110046734,
-0.0025538919,
0.0029997325,
0.007863596,
-0.007198066,
-0.016903179,
-0.023842786,
-0.028533805,
-0.012011853,
-0.03279837,
-0.014848433,
-0.018970845,
-0.02231788,
0.016761025,
-0.00015426734,
-0.013982599,
-0.0021936656,
0.010293105,
-0.013065071,
0.00473625,
-0.023532635,
0.006829763,
0.017730245,
0.009052505,
0.022783106,
0.0409915,
-0.014331517,
-0.032178067,
-0.019242227,
0.0064743822,
0.008774662,
-0.0102414135,
-0.017562246,
-0.019591145,
-0.009711574,
-0.013129686,
-0.020469904,
-0.015210276,
0.015765961,
-0.0024989694,
-0.019513607,
-0.03279837,
-0.003293729,
-0.009711574,
0.016554259,
-0.014835511,
-0.021271124,
-0.026853826,
0.01128817,
-0.011372169,
-0.020250214,
0.0148872025,
-0.030110402,
-0.020689594,
0.037657388,
0.024385547,
0.0061157714,
0.008606664,
0.0027235053,
-0.025044616,
-0.005905774,
-0.010118646,
-0.034788497,
0.0069912993,
-0.009265733,
0.051148914,
0.027525818,
0.03352205,
-0.024269242,
0.012063545,
-0.0047556343,
0.00836759,
0.014900126,
-0.016140725,
0.019358533,
-0.01850562,
0.025328921,
0.012509385,
0.0030869623,
0.018634848,
-0.0155075025,
0.005153014,
0.0056473156,
-0.004377639,
-0.0054373182,
-0.010842329,
-0.023648942,
-0.036029097,
0.032643292,
-0.0026443524,
0.011301093,
-0.020922206,
-0.006367768,
0.029335026,
0.0020014371,
0.022873567,
0.010215567,
-0.0030255783,
-0.026272295,
0.0047394806,
-0.02235665,
-0.0051077837,
-0.020612055,
-0.009614652,
0.0048364024,
0.010370643,
0.017691476,
-0.0026847364,
0.006516382,
0.0065616122,
-0.018221315,
0.012825997,
-0.0038445683,
-0.024954157,
-0.01474505,
-0.020133907,
-0.020444058,
-0.022020655,
-0.01788532,
0.0014392901,
-0.01425398,
0.0033276516,
-0.006335461,
-0.018117933,
-0.008309437,
-0.021839732,
-0.020392366,
0.029179951,
0.0016719026,
0.008619587,
-0.024514778,
0.0045747133,
0.029076567,
0.0029738867,
-0.024876619,
-0.019849604,
0.0030094248,
0.015494579,
0.028921492,
0.013672448,
0.004397023,
-0.020237291,
0.0021791272,
0.01788532,
-0.0035085725,
-0.035925716,
0.010958635,
0.0119795455,
0.0105774095,
-0.021749273,
-0.021710504,
-0.026517829,
0.0050464,
-0.005524548,
0.011514321,
-0.014667513,
-0.01474505,
-0.011223556,
0.012735536,
-0.025135078,
0.0108746365,
-0.018441005,
-0.008554973,
-0.009155888,
-0.030627318,
-0.012599846,
-0.0022550493,
0.009808496,
0.030420551,
-0.0032904982,
-0.0020127445,
0.0051885517,
-0.008671279,
-0.007721444,
0.0026362755,
-0.023170793,
0.042257946,
0.00030914045,
-0.000054720484,
0.011042634,
-0.005783006,
-0.005007631,
-0.023532635,
-0.0074048326,
0.000605358,
-0.028533805,
0.0035602641,
0.03600325,
0.0077989814,
-0.015662577,
0.022847721,
-0.030084556,
0.0050851684,
-0.04520437,
-0.018712386,
0.0052531664,
-0.02053452,
0.007366064,
0.011320477,
0.0032711138,
0.012774305,
0.016941946,
-0.009259271,
-0.00023362214,
0.027034746,
-0.041508414,
0.008690663,
-0.011514321,
0.02434678,
0.0011832548,
-0.014163519,
-0.015559195,
-0.029231643,
0.001576596,
-0.02107728,
-0.047272038,
-0.0088005075,
0.0003674955,
0.004064258,
0.007088221,
-0.0107260225,
0.04062966,
0.029722713,
0.014499515,
-0.0061157714,
-0.01624411,
0.021839732,
-0.0068426854,
-0.016618874,
0.033573743,
-0.007908827,
-0.009078351,
0.01912592,
0.014577053,
0.008483896,
0.018092087,
-0.013698294,
-0.013672448,
0.0081543615,
-0.026065528,
0.0092721945,
-0.011507859,
-0.009789111,
-0.01965576,
0.017368402,
-0.0005096476,
-0.018169625,
-0.0061448477,
0.008981429,
0.0027961966,
0.024682775,
-0.010771253,
-0.015352428,
0.0010087953,
-0.018777002,
-0.03861368,
-0.0036733397,
-0.005915466,
0.018596081,
0.008025133,
-0.00082868215,
-0.02107728,
0.0048816325,
-0.030834084,
-0.01288415,
0.017161636,
0.010506333,
0.009394962,
0.016941946,
-0.020172676,
0.022072345,
-0.027784275,
0.017006561,
-0.0024456624,
-0.031583615,
-0.008761739,
-0.02054744,
0.0164638,
0.026311062,
-0.012502924,
-0.019888373,
0.04197364,
0.008451589,
-0.01970745,
0.034426656,
-0.030162092,
0.016903179,
-0.04117242,
0.0135819875,
-0.041120727,
0.017678553,
0.026311062,
0.0116823185,
-0.009634036,
-0.001757517,
-0.003947952,
0.0039124135,
-0.003860722,
0.0013237915,
0.007372525,
-0.0046942504,
-0.00092641177,
-0.02899903,
0.01217339,
-0.022304958,
0.033909738,
0.01806624,
-0.0091106575,
-0.007863596,
-0.011721088,
-0.0075469846,
-0.029024877,
0.0076115993,
0.009220502,
0.019384379,
-0.008393436,
0.00894266,
-0.018092087,
0.0021145127,
0.002072513,
-0.017588092,
-0.02138743,
-0.0128130745,
0.009007274,
-0.023881555,
0.0061416174,
0.0042742556,
0.0034116507,
0.0017203636,
0.0024488932,
-0.01106848,
-0.041844413,
0.0048202486,
0.0004761288,
-0.013019841,
-0.011656472,
-0.012767844,
-0.00041474492,
-0.010693715,
-0.004245179,
-0.018789925,
-0.026259372,
0.01053864,
0.18867461,
-0.027474126,
0.0046813274,
0.019629914,
0.0054050107,
0.017433017,
0.030084556,
-0.021620043,
-0.015817653,
0.0006760302,
0.020353597,
-0.010409411,
-0.02275726,
0.0062191547,
0.0062353085,
-0.010196183,
-0.026905518,
0.0028268886,
-0.027138129,
-0.0034374965,
0.01239308,
0.0016605951,
0.00044907143,
-0.00035214954,
0.041844413,
0.019268071,
-0.014473669,
0.015533349,
0.022395419,
0.008587279,
-0.026776288,
0.010919866,
-0.012580462,
0.0039705667,
-0.00024008361,
0.0069977604,
-0.013174916,
-0.015287813,
0.0068103783,
-0.0002626987,
-0.018621925,
0.009310963,
0.008386974,
0.007882981,
0.016347492,
0.023829862,
-0.0068685315,
0.000074862066,
0.011449706,
-0.0032598062,
-0.016231187,
-0.003599033,
0.036054943,
0.007805443,
0.015494579,
0.008865123,
0.0329276,
-0.014809665,
0.018079164,
-0.008270668,
-0.013045686,
0.006060849,
-0.035046957,
0.018311776,
-0.024450162,
0.033005133,
-0.016903179,
0.011792163,
-0.014111827,
-0.0051950132,
0.0072368346,
-0.012470617,
-0.026750442,
-0.015830576,
-0.01332353,
-0.014757973,
0.02961933,
0.0028705033,
-0.0073337564,
0.010570948,
0.01881577,
0.014835511,
-0.023519712,
0.015998574,
-0.010932789,
-0.021632966,
0.01784655,
0.0048816325,
-0.033496205,
0.0070688366,
-0.005072246,
-0.009013736,
-0.010732484,
-0.006170694,
0.016140725,
-0.01394383,
0.0069008386,
-0.0037831846,
-0.000887643,
-0.018583158,
-0.022589263,
0.0782612,
0.008115593,
0.009659882,
-0.010751869,
0.008710047,
0.011010327,
-0.00513363,
0.00655192,
0.008884506,
0.01527489,
-0.037398927,
0.018027471,
0.0012688691,
-0.0016371723,
0.02071544,
-0.008794046,
-0.02341633,
0.017161636,
-0.0075276005,
-0.0058056214,
-0.016890256,
0.015882267,
0.026595367,
-0.012897073,
0.026091373,
-0.016166572,
0.0064356136,
-0.0064614597,
-0.015171506,
-0.007637445,
-0.0041224114,
0.00225828,
0.017497633,
0.021852655,
-0.03049809,
0.00048137872,
-0.0027929659,
-0.0183247,
0.021878501,
-0.014719205,
-0.007934672,
0.0077472897,
0.012916458,
0.0074759084,
0.0014174826,
0.022925258,
0.033754665,
-0.025264306,
-0.027861813,
-0.010325412,
-0.033806358,
-0.018479774,
-0.021154819,
0.027138129,
-0.034736805,
-0.009394962,
-0.03509865,
0.000029833769,
0.012128159,
-0.008432205,
0.031144235,
0.010693715,
-0.0067263795,
-0.0063871527,
-0.0061480785,
-0.1602442,
0.011217094,
0.022783106,
-0.03253991,
0.02315787,
0.01221862,
-0.003138654,
-0.018854538,
-0.0013318683,
0.010558025,
0.055310093,
-0.012935841,
-0.045307755,
0.013840446,
-0.0029464255,
-0.003258191,
-0.0095952675,
0.05171752,
0.034685116,
0.038045075,
0.029231643,
-0.04106904,
0.00028248693,
-0.0010201029,
-0.0023164332,
0.01784655,
0.005644085,
-0.031971302,
-0.0062546926,
-0.012057084,
-0.012367234,
0.011417399,
0.025005847,
-0.0052402434,
0.022550493,
-0.009550037,
0.017252097,
-0.00832236,
-0.002510277,
0.025574457,
0.042128716,
0.015352428,
0.027215667,
0.013026303,
-0.021038512,
0.03204884,
0.0015903267,
-0.005069015,
0.052311976,
-0.020172676,
0.018092087,
-0.017019484,
-0.003130577,
-0.0007830481,
0.017213328,
0.028559651,
0.008354667,
0.008063901,
-0.0053630113,
-0.004435792,
-0.004025489,
-0.025819993,
0.02726736,
-0.009614652,
0.01527489,
-0.016761025,
0.016127802,
0.028223654,
-0.0047620954,
-0.0061739245,
-0.028663034,
0.0047524036,
0.010202644,
-0.008496819,
0.020082217,
-0.0025232,
0.0053565498,
0.028792264,
0.0015911344,
0.0091235805,
-0.012845381,
-0.005198244,
-0.0070688366,
-0.0075728307,
-0.018880384,
0.0129616875,
-0.00042362945,
0.041146573,
-0.012832458,
-0.0015515579,
0.023752324,
-0.022072345,
0.000674011,
-0.007882981,
0.016967792,
0.037424773,
-0.006503459,
-0.012780767,
-0.014913049,
0.0035118032,
0.02049575,
-0.037657388,
-0.013258914,
-0.008735893,
0.010086338,
-0.007999287,
-0.022304958,
-0.011262324,
0.015869344,
-0.011662934,
-0.006348384,
0.013052148,
-0.0047879415,
0.005259628,
-0.018234238,
0.018402237,
-0.006183617,
0.020198522,
0.004180564,
-0.02598799,
0.06497644,
-0.005424395,
0.0015935574,
0.0037670308,
-0.0076697525,
-0.02474739,
-0.1148589,
-0.040526275,
0.0151844295,
-0.0042613326,
-0.013930907,
0.036235865,
-0.0177044,
0.028740572,
-0.01970745,
-0.0015636731,
-0.034504194,
0.01580473,
-0.014512438,
-0.018247161,
-0.006225616,
0.005808852,
0.009226964,
-0.008587279,
-0.029593484,
0.03471096,
0.0019675144,
-0.016050266,
0.018117933,
-0.002886657,
0.0007693175,
0.0055859317,
-0.024359703,
0.0022938182,
0.00420641,
0.013646603,
0.024915388,
0.011889085,
0.026491985,
-0.0123155415,
-0.013491527,
0.0022388957,
-0.014951817,
-0.03372882,
0.029128259,
-0.0065325354,
-0.001419098,
0.0033567282,
-0.005721622,
-0.00014810877,
-0.0055600856,
-0.010596793,
-0.03471096,
-0.0024537393,
0.0422321,
-0.025315998,
-0.041120727,
-0.02257634,
-0.02054744,
0.00021524738,
0.00854205,
0.012444771,
0.012270312,
0.003599033,
-0.01394383,
0.006694072,
0.015068123,
-0.00017950742,
-0.012444771,
0.002550661,
0.028223654,
-0.020082217,
-0.0030659626,
-0.02961933,
0.014938895,
-0.026259372,
-0.0031903456,
-0.019500684,
-0.01828593,
-0.02479908,
-0.002749351,
0.0008690663,
-0.018634848,
-0.018169625,
0.01788532,
-0.020224368,
-0.017575169,
-0.01664472,
0.019940063,
-0.0034213427,
0.05233782,
0.016127802,
0.0014061751,
-0.021710504,
0.008128516,
0.0017704399,
-0.010900483,
0.023984937,
0.0029480408,
-0.016476722,
-0.0034568808,
0.016709333,
-0.0028010427,
0.007650368,
0.028663034,
0.016179495,
-0.0056731612,
-0.02169758,
-0.045772977,
0.030343013,
-0.020728363,
-0.0010701793,
-0.0064679207,
-0.007773136,
0.015300736,
-0.023390483,
0.02837873,
0.023713557,
0.0061739245,
-0.005246705,
-0.00060697336,
0.0062450008,
-0.024010783,
-0.0024585854,
0.009640497,
0.005476087,
0.005353319,
0.012076467,
0.0076568294,
0.0062676156,
-0.0018657465,
0.009601729,
0.00013397432,
-0.012645076,
0.009239887,
0.022899412,
-0.012011853,
-0.021671735,
0.006215924,
-0.026052605,
-0.011604781,
0.004377639,
-0.01620534,
-0.02129697,
-0.00078345195,
0.03396143,
0.018583158,
0.045902207,
-0.008897429,
-0.04086227,
0.025690762,
-0.0028446575,
-0.0010855251,
-0.009226964,
-0.033754665,
0.015778884,
-0.0052790125,
-0.007411294,
0.03297929,
0.017601015,
-0.009194657,
-0.027965197,
-0.0129616875,
-0.0015362119,
-0.009730958,
-0.0054340875,
-0.032178067,
-0.009388501,
0.008987891,
0.014925972,
-0.0005427626,
0.029722713,
-0.003944721,
-0.026052605,
-0.048150796,
-0.0036733397,
0.007637445,
-0.00015467119,
-0.031971302,
0.015081046,
-0.019216381,
-0.011016788,
0.01850562,
-0.0066359187,
-0.032643292,
0.009039582,
-0.0015507502,
0.026466139,
0.011281708,
-0.0065616122,
-0.019733297,
-0.0020531288,
0.029593484,
0.012367234,
-0.014822588,
0.016993638,
0.01292938,
-0.015494579,
0.009853725,
0.024669852,
0.0054663946,
0.01673518,
0.018712386,
0.02315787,
0.009860187,
0.012024776,
0.0006029349,
0.052441206,
0.019280994,
-0.015442888,
0.008393436,
-0.0038090304,
-0.004300101,
0.016360415,
-0.04507514,
-0.028094426,
-0.023881555,
0.001213139,
0.0074048326,
0.011314016,
-0.003267883,
0.0043550236,
-0.02788766,
0.011611243,
-0.003369651,
-0.00624177,
-0.013969676,
0.023791093,
0.020909283,
0.017213328,
-0.03155777,
-0.015223199,
-0.010286643,
-0.005873467,
0.034607578,
-0.017368402,
0.024372624,
-0.0044002538,
0.011624166,
-0.009705112,
-0.034943573,
-0.0162958,
-0.00029763096,
0.0010847175,
0.025044616,
0.014473669,
0.001091179,
0.07340218,
-0.0020531288,
-0.00894266,
-0.0016339415,
-0.024992926,
0.011611243,
0.019539453,
0.026853826,
-0.006057618,
-0.03688201,
0.017290866,
-0.0037185699,
0.032074686,
-0.023687711,
-0.045566212,
0.008748816,
-0.00491394,
-0.010919866,
-0.0075922147,
-0.011307554,
0.014913049,
-0.011611243,
0.0077472897,
0.002253434,
-0.04404131,
-0.002647583,
0.023661865,
-0.006600381,
0.0034407272,
-0.028585497,
-0.009886033,
0.011876162,
-0.048150796,
-0.009323886,
0.009091274,
-0.006564843,
-0.0048848633,
-0.029515946,
0.015326582,
0.012115236,
-0.00792821,
0.039673362,
-0.028895646,
-0.028714726,
-0.0003987932,
-0.0059283893,
-0.026349831,
-0.0052790125,
-0.016347492
] |
PURPOSE Circulating tumor cells (CTCs) and [(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) are two new promising tools for therapeutic monitoring. In this study, we compared the prognostic value of CTC and FDG-PET/CT monitoring during systemic therapy for metastatic breast cancer (MBC). PATIENTS AND METHODS A retrospective analyses of 115 MBC patients who started a new line of therapy and who had CTC counts and FDG-PET/CT scans performed at baseline and at 9 to 12 | [
-0.034599345,
-0.006649194,
0.0130499415,
-0.020437935,
0.00026989874,
0.001670471,
-0.046943177,
-0.0030320194,
-0.04077126,
0.00033732236,
0.0091532655,
0.0352793,
0.0025433002,
0.0110492995,
-0.029970407,
0.012356909,
0.035331607,
-0.0020398707,
-0.035828497,
-0.0055998373,
-0.011879631,
0.023654655,
-0.012834186,
-0.0035468906,
0.0031284555,
0.019104173,
0.023772338,
-0.04414489,
0.0070480146,
-0.015037508,
0.009918218,
0.0070741666,
-0.029551972,
-0.006449783,
0.002021891,
0.0025956046,
0.019208781,
0.014082953,
0.019274162,
0.004220309,
-0.00525659,
0.016959693,
0.013095708,
-0.015926681,
-0.006714574,
-0.013651442,
0.012683811,
-0.02527609,
-0.016122824,
0.018267304,
-0.007845656,
0.003752839,
-0.014540616,
-0.0002837921,
-0.011487348,
-0.006989172,
0.00180777,
0.04137276,
-0.015926681,
-0.03143493,
0.00094883406,
-0.010931615,
-0.014043725,
0.02236012,
0.0018339221,
-0.012945333,
-0.005580223,
0.026387557,
-0.001894399,
0.0149982795,
0.010565484,
0.03765915,
-0.0008103092,
-0.010245119,
0.022216283,
-0.012964947,
-0.022843936,
-0.014802138,
-0.013036866,
0.015155192,
0.019025717,
-0.03248102,
0.001153148,
0.023811568,
0.015011356,
0.02688445,
-0.024399992,
0.006708036,
0.0046845106,
0.006845335,
0.029028928,
0.029316602,
0.00612615,
0.006099998,
-0.0068714875,
0.015351335,
-0.011990778,
0.039280586,
0.011860017,
-0.030519603,
0.0010885848,
0.020817142,
-0.0161359,
-0.0076102866,
-0.009558625,
0.011140832,
0.011493887,
-0.025498383,
0.018031934,
-0.030754972,
-0.015691312,
0.046943177,
-0.0057273293,
0.007237618,
0.018868804,
0.010545869,
0.016148975,
-0.017430434,
-0.008950586,
0.0035272762,
0.015795922,
-0.012062697,
0.03907137,
-0.016776629,
0.021379413,
-0.017456586,
-0.011971164,
-0.019927967,
-0.0063713267,
0.005841745,
-0.017718107,
-0.0075645205,
0.019574912,
0.015272878,
-0.022687024,
-0.002497534,
-0.023432361,
-0.0068584112,
-0.027198276,
-0.03609002,
-0.014540616,
0.03248102,
0.001948338,
-0.011572343,
-0.04312496,
0.0075645205,
0.014396779,
0.023432361,
0.01559978,
-0.024883807,
-0.021588631,
-0.021470945,
0.0047041248,
-0.0011106507,
-0.017051226,
-0.019875662,
0.004900266,
0.018973412,
-0.010035902,
-0.0060803834,
-0.0045210593,
0.010493565,
0.02096098,
0.00783258,
0.016750475,
0.02032025,
0.009042119,
0.014632149,
0.0061653783,
-0.018162694,
0.016724324,
0.028375125,
-0.009669771,
0.008532152,
-0.019104173,
0.01252036,
-0.02587759,
0.010683169,
-0.014775986,
-0.032742538,
0.008166021,
0.029264297,
0.0036743823,
-0.013572985,
-0.0014538981,
-0.0024092703,
0.0143837035,
-0.007061091,
-0.011814251,
-0.03428552,
0.0029601008,
0.023092382,
0.01710353,
-0.010245119,
-0.6393687,
-0.025916819,
0.012559588,
-0.018672662,
0.012938795,
0.020097956,
0.01817577,
-0.014932899,
-0.028662797,
0.015285954,
0.029891951,
0.025328394,
0.013180703,
-0.007793352,
-0.0065740063,
-0.025380699,
-0.03237641,
-0.012206534,
0.0029208725,
0.00215919,
-0.0352793,
0.024556905,
-0.02126173,
0.011559267,
-0.006005196,
0.011055837,
0.010912,
0.006122881,
0.013729898,
0.059470076,
-0.026021427,
0.030075016,
0.003752839,
-0.019823357,
0.037711456,
-0.009159803,
-0.016253585,
0.0014056801,
0.0030369228,
0.03551467,
-0.0014767813,
-0.0020970786,
0.033291735,
-0.006812645,
-0.033788625,
0.03242871,
-0.007943727,
-0.008035259,
-0.0043804916,
-0.005462538,
0.008107178,
0.025746828,
-0.024530752,
-0.004998337,
0.007943727,
0.0019254548,
0.010964305,
-0.018463444,
-0.012677273,
-0.005740405,
0.02881971,
0.0066361176,
-0.0073029986,
-0.023027001,
-0.01800578,
0.02664908,
-0.0041157007,
-0.0007988676,
0.025864514,
-0.006779955,
0.038443714,
0.027956689,
-0.0115135005,
0.008930972,
0.0585809,
0.012670735,
0.027930537,
-0.0036613063,
0.0020513122,
-0.0002839964,
0.0060575004,
0.0022948545,
-0.030938039,
0.028479733,
0.0032412368,
0.00018919473,
-0.033919387,
0.009970522,
0.026073731,
0.006580544,
-0.0068976395,
0.016685097,
-0.024766121,
-0.028558189,
-0.0087936735,
0.010068593,
-0.0006934416,
0.0049493015,
0.01559978,
-0.045583263,
-0.0328733,
-0.021209424,
0.017966554,
0.012095387,
0.006384403,
-0.00008652697,
-0.03428552,
0.00723108,
0.009414787,
-0.025616068,
0.006041155,
-0.02396848,
-0.012670735,
-0.007270308,
0.0060803834,
-0.019051868,
0.0035959259,
0.016750475,
-0.018228075,
-0.013520681,
0.018424217,
0.0012389598,
0.0047956575,
0.0035142002,
0.006113074,
0.0033098862,
0.011931935,
-0.016711248,
0.0067734164,
-0.013311463,
-0.0071983896,
-0.0021068857,
0.016096672,
-0.018764194,
0.013546833,
-0.023040077,
0.020333325,
-0.0035991948,
-0.015102888,
-0.037580695,
-0.03480856,
0.00058147754,
0.018633435,
0.020058729,
0.02587759,
-0.013213393,
-0.030414995,
-0.0016157149,
-0.008198711,
0.010388956,
-0.023523893,
-0.0044001057,
0.009414787,
0.00893751,
0.010977381,
-0.0069107157,
0.0025465693,
-0.033971693,
0.0046583586,
-0.030911885,
-0.002487727,
0.001878054,
-0.0018290186,
-0.010532794,
-0.0070087863,
-0.012043082,
0.0059300084,
0.026688308,
0.0018486328,
-0.032559473,
-0.01369067,
-0.01593976,
-0.00532197,
0.023013925,
0.009826684,
0.0027361726,
-0.010885848,
-0.014893671,
-0.0009300372,
-0.022791632,
0.006799569,
0.004890459,
-0.0021444794,
0.0074729878,
0.02798284,
0.0010477221,
0.009225184,
0.0049493015,
-0.025903743,
0.021484023,
-0.006845335,
0.019640293,
-0.018071162,
0.012180381,
0.0033458455,
-0.013311463,
-0.0071395473,
-0.012879953,
0.0017080648,
0.028427428,
0.032167193,
-0.002564549,
0.02714597,
0.004749891,
0.0006599341,
-0.019627217,
0.0070741666,
-0.006263449,
0.019574912,
0.0042268476,
0.009539011,
0.006109805,
0.00038431457,
0.003759377,
-0.023079306,
0.01948338,
0.0019532414,
-0.017613498,
0.006668808,
-0.017953478,
-0.016815856,
-0.007492602,
0.029891951,
0.0032379678,
0.014030648,
0.009323255,
0.012141153,
-0.005995389,
0.016057443,
0.000012373765,
-0.020660229,
0.031591844,
0.01148081,
0.027956689,
0.023523893,
-0.005008144,
0.024125393,
-0.0058352067,
0.042026564,
0.008421005,
0.00025988737,
0.014749834,
0.009493244,
-0.013821431,
-0.006436707,
0.0021510175,
0.0120234685,
0.03201028,
-0.002919238,
0.0022915856,
-0.00860407,
0.001153148,
-0.029944254,
0.019208781,
0.013017251,
0.0034128604,
0.013912964,
-0.0025187826,
0.042837285,
0.02229474,
0.027825927,
0.005014682,
-0.003063075,
-0.010003212,
0.005305625,
0.024347687,
0.020516392,
-0.029342754,
0.0061947997,
0.000014416904,
-0.0017015267,
0.009650157,
-0.0034259367,
-0.02881971,
0.0074729878,
0.0015642277,
0.0161359,
0.006734188,
0.029578125,
0.018424217,
-0.0014048629,
-0.040509738,
0.019064944,
0.028270515,
-0.008296781,
-0.024543827,
-0.006708036,
0.00013362133,
-0.004606054,
-0.013193779,
0.008094102,
-0.004138584,
-0.011454659,
0.012657659,
-0.012186919,
-0.027067514,
-0.0038737927,
0.007093781,
0.007688743,
0.018188847,
-0.005547533,
0.015691312,
-0.013978344,
-0.029604277,
0.021314032,
0.017351976,
-0.016162053,
-0.02229474,
-0.020346401,
-0.008551765,
0.005442924,
-0.015272878,
-0.0008254284,
-0.022320893,
-0.0029601008,
0.015076736,
0.0057698265,
0.022020143,
0.019091098,
0.0029372175,
-0.021824,
0.00029625525,
-0.00008744638,
-0.009813609,
0.039986696,
0.02534147,
0.015351335,
-0.021340186,
-0.0068976395,
0.00083687,
-0.0070284004,
-0.0014212079,
0.023811568,
-0.0009112403,
0.004573364,
0.010944691,
0.0038639857,
-0.0014988473,
0.0010297424,
0.01841114,
-0.0066295797,
-0.023236219,
0.002165728,
0.008682527,
-0.0004006597,
-0.0015421618,
0.041660435,
0.026034502,
0.009107499,
-0.0067538023,
0.021065587,
0.018515749,
0.0033033483,
-0.002871837,
-0.017090455,
0.020830218,
0.012095387,
-0.002584163,
-0.007897961,
-0.017090455,
0.0010272906,
-0.004746622,
0.012069235,
-0.003076151,
0.009800532,
0.009493244,
0.0038084122,
0.0077279713,
0.019836435,
0.010153587,
0.007374917,
0.024295382,
0.022608567,
-0.0077018193,
0.036900736,
-0.0046518203,
-0.012592278,
-0.01626666,
0.011278131,
0.0105393315,
-0.0057861716,
-0.0265837,
-0.018332684,
-0.00094556506,
0.0038345645,
-0.028427428,
0.003478241,
0.0025269552,
-0.009454016,
-0.0005679928,
-0.009905141,
-0.02600835,
-0.012932257,
0.0055279187,
-0.021745544,
-0.023785414,
-0.010094744,
-0.011003533,
0.006864949,
0.013507605,
0.008035259,
-0.008545227,
-0.0143313985,
0.0185419,
-0.009944369,
-0.0019597795,
-0.0037495699,
-0.032167193,
0.00014158958,
0.0016622985,
-0.0025318586,
-0.020673305,
-0.017587347,
0.04111124,
0.00027378072,
-0.024936112,
-0.0009145093,
0.011395816,
-0.011075452,
0.012030006,
-0.009754766,
-0.0149459755,
0.0065020877,
0.0053677363,
0.0065020877,
-0.021732468,
-0.0074795256,
-0.024099242,
-0.0037136106,
0.010212429,
0.0062274896,
-0.010336652,
-0.0015536034,
-0.006603427,
0.014135257,
-0.0173389,
-0.0043772226,
0.0062307585,
0.025629144,
0.029996559,
-0.014135257,
0.008244477,
0.012808034,
0.0000037223451,
0.013586061,
0.009610929,
0.026962906,
-0.012775344,
-0.0031529733,
-0.0031644148,
0.0017816178,
-0.027355189,
-0.017351976,
-0.0067538023,
-0.018816499,
0.025746828,
-0.010048978,
-0.022987774,
-0.028427428,
-0.0038607167,
-0.013507605,
0.00242725,
0.01570439,
-0.007211466,
-0.040248215,
0.018463444,
0.012317681,
-0.026047578,
0.030571908,
-0.022281663,
-0.0034095915,
0.020673305,
0.0027443452,
0.032245647,
-0.00866945,
0.015495171,
-0.03201028,
-0.0051225596,
-0.018332684,
-0.039019063,
-0.013259159,
0.0025629145,
0.04435411,
0.022177055,
0.023432361,
0.013350692,
0.014906747,
0.013638366,
0.0053677363,
0.006001927,
-0.009042119,
0.007780276,
0.00060926424,
0.016580487,
-0.012343832,
-0.016384346,
-0.009480168,
-0.015272878,
0.008440618,
0.010715859,
-0.016449725,
-0.0023586005,
0.0066263108,
-0.014867519,
-0.046943177,
0.009375559,
0.0056586796,
0.016371269,
-0.044981763,
-0.023393132,
0.0060444246,
0.0120234685,
0.0042987657,
-0.0043935673,
0.035645433,
-0.025433002,
-0.008427543,
-0.014645225,
-0.020137185,
-0.014658301,
-0.02126173,
-0.011023147,
-0.021667087,
0.016122824,
0.019771054,
0.010349728,
0.0060640387,
0.013546833,
0.0015421618,
-0.009342869,
-0.02929045,
-0.008028721,
-0.020830218,
-0.027956689,
-0.023523893,
-0.00024006891,
-0.021444794,
-0.012657659,
0.0027100204,
0.010996995,
-0.02725058,
0.015037508,
0.010284347,
-0.020516392,
0.022778556,
0.0004915794,
0.0029829838,
-0.01027781,
0.031382624,
0.010663555,
-0.0021085201,
-0.03310867,
-0.02594297,
-0.017456586,
0.021693239,
0.020294098,
0.031382624,
-0.0028702025,
0.002299758,
0.012834186,
0.029944254,
-0.004998337,
-0.030650364,
0.017417356,
0.019810282,
-0.011023147,
-0.029970407,
-0.025263013,
-0.03130417,
0.024478449,
-0.0035697736,
0.0056325276,
0.0016533086,
0.0010607981,
-0.016724324,
0.03289945,
-0.025053795,
0.019038793,
-0.007780276,
0.0023716765,
-0.0029682734,
0.004158198,
-0.022608567,
0.007119933,
-0.0030369228,
0.021640936,
0.0041189697,
-0.018384987,
0.015586704,
-0.018921107,
-0.017888097,
-0.0069107157,
-0.028636646,
0.04027437,
0.0058940495,
0.016920466,
0.014919823,
0.00019920612,
0.011618109,
-0.010683169,
-0.008774059,
-0.00810064,
-0.020359479,
-0.005426579,
0.037920672,
0.021980913,
-0.02918584,
-0.0031922015,
-0.0227001,
0.0064824736,
-0.023053154,
-0.015808998,
0.020882523,
-0.052775115,
-0.015756693,
0.016214356,
0.03441628,
0.040248215,
0.0004633841,
-0.015351335,
0.002737807,
0.033867083,
-0.018724967,
0.014239866,
0.0022572607,
-0.00361554,
-0.029839646,
0.007930651,
-0.012154229,
-0.0245046,
-0.011709642,
-0.016475879,
-0.026191415,
-0.033422496,
-0.0133049255,
0.009081347,
0.021379413,
-0.019601064,
0.028532038,
0.027642863,
0.007897961,
-0.020843294,
-0.0049525704,
0.010205891,
-0.02032025,
0.0064628595,
0.023550045,
-0.00649555,
0.0052435137,
-0.014775986,
-0.0074664494,
0.012513822,
0.010755087,
-0.011474272,
-0.027302884,
0.030885734,
-0.024295382,
-0.0007007969,
-0.019705674,
-0.005586761,
-0.0233016,
0.014815214,
-0.009525934,
0.008054874,
0.0002748023,
-0.02349774,
-0.02426923,
-0.0006100815,
-0.029028928,
-0.026570622,
-0.029656582,
-0.01643665,
-0.012886491,
-0.003893407,
-0.023040077,
0.0013313098,
0.012670735,
-0.013416072,
-0.033945538,
-0.011376202,
-0.032324106,
-0.012128077,
0.014880595,
0.037737608,
-0.002909431,
0.015926681,
-0.018071162,
0.031565692,
0.0060673077,
0.008218325,
-0.0046420135,
-0.008734831,
0.02319699,
-0.013108784,
0.027512101,
-0.0015993697,
-0.03849602,
-0.015429791,
0.0101274345,
0.00029523368,
-0.0065249708,
0.019731825,
-0.014553692,
0.029970407,
-0.016998922,
-0.022582414,
-0.015129041,
0.011546191,
-0.003638423,
-0.0098201465,
0.012736116,
0.021654012,
-0.005348122,
0.011572343,
-0.013246083,
0.022007067,
0.00923826,
0.007884884,
-0.02677984,
-0.025537612,
0.014736758,
-0.009107499,
-0.012409213,
0.02366773,
0.010192815,
0.014082953,
0.023092382,
0.013599138,
-0.012723039,
-0.012095387,
-0.004998337,
-0.020738686,
0.004200695,
0.006253642,
-0.0042268476,
0.01800578,
0.015913606,
-0.007244156,
-0.022974696,
-0.0018355567,
-0.024909958,
-0.017155835,
0.020542543,
0.015639009,
-0.018724967,
-0.0129976375,
-0.0034030534,
-0.017783487,
-0.020660229,
-0.013115322,
-0.0045308666,
-0.031617995,
0.0053971577,
-0.013847583,
0.008087564,
0.0052304375,
-0.0035338143,
-0.006237297,
-0.0038803308,
-0.00035305452,
0.19802436,
-0.010905462,
-0.00082297664,
0.034050148,
0.008362162,
-0.0069107157,
0.0200195,
0.0075906725,
0.00472047,
0.00977438,
0.021209424,
-0.016188204,
-0.02725058,
0.0027655938,
-0.005410234,
0.01978413,
-0.016554335,
-0.025289165,
-0.004458948,
-0.015952835,
-0.009388636,
0.0070349383,
0.014266019,
-0.00870214,
0.001938531,
-0.019326467,
0.012010392,
-0.00041005813,
0.037580695,
0.007682205,
-0.027695166,
0.012402675,
0.00572406,
-0.006149033,
0.0015920145,
0.008656374,
-0.01476291,
0.0010673362,
-0.019261086,
-0.015455943,
-0.0020104495,
-0.01329185,
-0.028558189,
-0.00049525703,
0.005995389,
0.030284233,
-0.002433788,
-0.015573628,
0.014789063,
-0.000062877625,
-0.03846987,
0.00089326064,
0.019300314,
-0.0017260443,
-0.007270308,
0.00033425764,
0.020581773,
-0.0026070462,
-0.0185419,
0.0088982815,
-0.015246726,
-0.0026184877,
-0.02714597,
0.042497303,
-0.017234292,
0.026021427,
-0.024230001,
0.008094102,
0.016044367,
0.008244477,
0.013429148,
0.005436386,
0.0075906725,
0.005629258,
0.009434402,
-0.017195063,
0.019391848,
0.010415109,
0.018214999,
0.028558189,
0.011036223,
0.004024168,
-0.012389599,
-0.011657338,
-0.014109105,
-0.02664908,
0.015168269,
0.016358193,
-0.018332684,
0.012559588,
0.0034913172,
-0.0013059749,
-0.020254869,
0.011029685,
0.016789705,
0.0063419053,
0.005066986,
0.010062054,
0.0012528532,
0.010676631,
-0.021510174,
0.07866578,
0.018986488,
0.012964947,
0.007577596,
0.014174486,
-0.02711982,
-0.002028429,
-0.011278131,
0.0062176827,
0.0044916384,
-0.038182195,
-0.002855492,
-0.009342869,
-0.01081393,
0.029918103,
0.016018216,
-0.022543186,
0.004001285,
-0.021954762,
0.00022740144,
-0.014697529,
-0.014082953,
0.024308458,
-0.01864651,
-0.0019679521,
-0.009682847,
-0.015469019,
-0.004311842,
-0.019535685,
-0.019261086,
-0.0024681126,
-0.001315782,
0.00010491522,
0.024308458,
0.009087885,
0.018711891,
-0.0046420135,
-0.049218416,
0.021013282,
0.0003236333,
-0.0063778646,
-0.013082632,
0.019980272,
0.019418,
-0.023419283,
-0.0018192115,
0.010598174,
-0.023157762,
-0.036769975,
-0.016488954,
-0.012768806,
-0.02096098,
0.0017162373,
0.026805993,
-0.023680806,
-0.0033801703,
-0.017312748,
-0.0011163715,
-0.0028783751,
-0.036979195,
-0.025969122,
0.022582414,
-0.013350692,
0.0068976395,
0.0200195,
-0.1637127,
0.002674061,
0.01312186,
-0.019836435,
-0.011258516,
0.004020899,
0.011010071,
-0.012441903,
-0.012526898,
0.006708036,
0.03420706,
0.0064661284,
-0.031121103,
-0.0046583586,
0.0025269552,
0.01600514,
-0.0029878875,
0.048721526,
0.010689707,
0.008107178,
0.028165907,
-0.016750475,
0.026753688,
-0.03297791,
-0.010604712,
0.004874114,
-0.0126903495,
0.016227432,
-0.023550045,
-0.0032543128,
-0.017025074,
-0.0045406735,
0.03187952,
-0.0043935673,
0.009316717,
-0.0012626604,
-0.025393775,
-0.015992062,
-0.009722075,
0.011990778,
0.02222936,
0.015887454,
0.0018764195,
-0.019941043,
-0.0087936735,
0.0191434,
0.014919823,
-0.00699571,
0.00974169,
0.0078064282,
0.028165907,
0.0042333854,
0.0049558394,
0.0009202301,
0.0016189839,
0.0016247047,
0.0107420115,
0.0016819126,
0.02785208,
0.00893751,
-0.006969558,
-0.03368402,
-0.014475236,
-0.0022850474,
-0.021130968,
-0.039123673,
-0.018515749,
-0.00031709528,
-0.020150261,
-0.0033082517,
-0.029368907,
-0.015508248,
0.014200638,
-0.023680806,
0.029970407,
0.020568695,
-0.013808355,
0.025956046,
0.0007183679,
0.014710606,
0.010683169,
0.0037136106,
-0.029264297,
-0.0037038035,
0.0022311085,
-0.0062471037,
0.015625931,
0.017011998,
-0.023249295,
-0.008185634,
0.011663876,
-0.029316602,
0.02832282,
-0.018450368,
0.005459269,
0.017613498,
-0.0007375734,
-0.01600514,
0.0037136106,
-0.019823357,
0.026099883,
-0.027956689,
-0.026910601,
-0.0014653398,
0.03323943,
0.0126903495,
0.0019957388,
-0.0001470039,
0.044667937,
0.0048414236,
-0.023353904,
-0.0006010917,
0.0054004267,
0.023170838,
0.0097678425,
0.016345117,
0.017914249,
0.0033360384,
-0.0006664722,
-0.015926681,
0.058267076,
-0.0028996237,
-0.029395059,
0.0406405,
-0.0014351013,
0.0021788043,
-0.13201624,
-0.023118533,
0.0063255606,
0.037240714,
0.0064628595,
0.028558189,
-0.012311142,
0.00096027565,
-0.011173522,
0.029735038,
0.002350428,
-0.011127756,
-0.017417356,
0.0063255606,
0.023680806,
-0.017312748,
0.019274162,
-0.011160446,
0.0022311085,
0.02038563,
0.019234935,
-0.0024730163,
0.0070741666,
-0.020241793,
0.013337616,
-0.0022278395,
-0.022634719,
0.013226469,
0.017822716,
0.019653369,
0.001293716,
-0.0074402974,
0.015652085,
-0.0014498119,
-0.014096029,
-0.006109805,
-0.016881237,
-0.038679086,
0.032925606,
-0.0010166663,
-0.006665539,
0.004138584,
0.006263449,
0.019705674,
0.0043576085,
-0.019601064,
-0.04181735,
-0.008237939,
0.009375559,
-0.028532038,
-0.005985582,
-0.04506022,
-0.0009725345,
0.00502122,
-0.0025253207,
-0.010369343,
0.012526898,
0.008211787,
-0.015848225,
-0.0047106626,
-0.0012030007,
-0.012239224,
-0.020934826,
0.02915969,
-0.00693033,
-0.0041026245,
-0.017195063,
-0.010088206,
0.0014767813,
-0.010029364,
-0.0161359,
0.00014158958,
-0.025694525,
-0.0076102866,
-0.033422496,
-0.010526256,
0.011487348,
-0.0068714875,
0.012461517,
-0.04027437,
-0.021954762,
-0.021915533,
0.016789705,
-0.021104816,
0.044380262,
0.016475879,
0.0070414767,
-0.0049264184,
0.007093781,
0.0035991948,
0.01660664,
0.046210915,
-0.019653369,
-0.028558189,
-0.018267304,
0.01061125,
-0.01386066,
-0.0067930305,
0.021039436,
0.03012732,
-0.013429148,
-0.023589274,
-0.06564199,
-0.0025449349,
0.028898168,
0.008865592,
0.009532472,
-0.020594848,
0.014815214,
-0.010552408,
0.022634719,
0.019156478,
-0.02319699,
0.011565805,
-0.006969558,
0.011042762,
-0.024399992,
-0.0122523,
-0.00013433643,
0.004069934,
0.020137185,
0.028976625,
-0.0025580109,
-0.003331135,
0.017691955,
0.0053513916,
-0.0070022484,
0.016711248,
-0.008643298,
0.037345324,
-0.02772132,
-0.022268588,
0.005831938,
-0.0035207383,
-0.016162053,
-0.0078064282,
-0.0022948545,
-0.0042431923,
-0.020163337,
0.0322718,
-0.009427864,
0.014252942,
-0.0064432453,
-0.021824,
0.026962906,
-0.009846299,
-0.023040077,
0.011886169,
-0.016070519,
0.013586061,
-0.0074468353,
0.018738043,
0.009401712,
0.004161467,
0.011565805,
-0.03454704,
-0.017888097,
0.0054919594,
-0.0028930858,
-0.0042791516,
-0.037842214,
-0.017116606,
0.033945538,
0.030781126,
0.001565045,
0.011323897,
0.026936753,
-0.0020872715,
-0.021052511,
-0.02456998,
0.016711248,
-0.032820996,
-0.021078663,
0.0011261785,
0.020189488,
0.00883944,
0.015390563,
-0.027956689,
-0.020058729,
0.007119933,
0.02289624,
0.024949187,
0.02420385,
0.0024109047,
-0.010421647,
0.007106857,
0.02858434,
-0.00016498353,
-0.018554978,
0.03310867,
-0.0005540995,
0.003277196,
0.008146406,
0.014475236,
0.01858113,
0.0025825286,
0.0064857425,
0.018894956,
0.00084340805,
0.023157762,
0.0060346173,
0.040012848,
0.004697587,
-0.009454016,
-0.0059234705,
0.0019156478,
-0.0048250784,
-0.0027394416,
-0.016148975,
-0.02092175,
-0.026714459,
0.021980913,
0.010676631,
0.015691312,
0.009911679,
-0.0013909695,
-0.018659586,
0.006603427,
-0.0033458455,
-0.003942442,
-0.009990136,
0.014959051,
0.015233649,
0.004998337,
-0.0029519282,
0.011395816,
0.02296162,
-0.0064693973,
0.037031498,
-0.016580487,
0.00977438,
0.0032314297,
0.004566826,
0.005874435,
-0.022791632,
-0.012199996,
0.007276846,
-0.018698813,
0.012396137,
-0.002437057,
-0.00074615463,
0.077619694,
0.020267945,
-0.025459155,
-0.0046845106,
-0.018999564,
0.021693239,
0.03491317,
0.02714597,
-0.012056159,
-0.02527609,
0.024308458,
-0.01804501,
0.0049329563,
-0.047021635,
-0.021484023,
0.02557684,
0.0038312955,
-0.0039326353,
0.0059136637,
-0.003507662,
0.011775022,
-0.01338992,
0.005295818,
0.020451011,
-0.017064303,
-0.0013084266,
0.012866876,
0.0065086256,
-0.0027835735,
-0.02426923,
0.0033769011,
-0.013416072,
-0.013612214,
-0.008963662,
0.044667937,
-0.003877062,
-0.00528928,
-0.05439655,
0.01811039,
0.032141037,
-0.0021918803,
0.015194421,
-0.010186277,
-0.012311142,
-0.025249938,
-0.014357551,
-0.005547533,
-0.011153908,
-0.016175129
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.