text
stringlengths 174
850
| embeddings_A
sequence |
|---|---|
The product of the gene mutated in Bloom's syndrome, BLM, is a 3′–5′ DNA helicase belonging to the highly conserved RecQ family. In addition to a conventional DNA strand separation activity, BLM catalyzes both the disruption of non-B-form DNA, such as G-quadruplexes, and the branch migration of Holliday junctions. Here, we have characterized a new activity for BLM: the promotion of single-stranded DNA (ssDNA) annealing. This activity does not require Mg2+, is inhibited by ssDNA binding proteins and ATP, and is dependent on DNA | [
-0.046695355,
-0.0025775423,
-0.00045111295,
-0.024518505,
-0.036061488,
0.037163444,
-0.009056695,
0.01684614,
-0.030717004,
-0.0037225427,
-0.004948468,
0.0059264535,
0.011660065,
0.02787947,
-0.017589962,
0.014256546,
0.015881931,
-0.010895583,
-0.0035365878,
0.0019938503,
-0.029284462,
0.00842307,
0.007114499,
-0.028540643,
-0.0042735203,
-0.0068975515,
0.016804818,
-0.035069726,
-0.014532035,
0.017906774,
0.00891895,
0.0014084366,
-0.004755626,
-0.0021746398,
-0.007169597,
-0.0053858063,
0.024201693,
-0.0004315274,
0.015055465,
-0.037301186,
0.016419133,
0.00042507064,
-0.013519614,
0.006573852,
-0.016295163,
-0.007651702,
0.015179434,
-0.014835073,
-0.008216454,
-0.010220636,
0.016446684,
0.013161479,
-0.016887465,
0.020055586,
-0.016556878,
0.0077068,
0.031240433,
0.009036033,
-0.00845062,
0.005805927,
-0.0047659567,
-0.0018922639,
-0.018168489,
0.014022381,
0.010248184,
-0.0030717005,
0.007465747,
-0.011067764,
0.01736957,
-0.012500306,
0.024546053,
0.009352845,
-0.003956708,
-0.0116945,
0.009890049,
-0.016432907,
-0.030248674,
-0.015592667,
-0.010275733,
0.005533882,
0.025937272,
0.0053134905,
-0.0004976017,
0.020041812,
0.020441271,
0.023995077,
-0.024366986,
0.0141601255,
-0.015427374,
-0.0035503623,
0.013650471,
0.022851799,
0.024766445,
0.019036278,
-0.040386662,
0.0037569788,
0.010923132,
0.024174144,
-0.00040656124,
-0.030276222,
-0.014518261,
-0.011164185,
-0.013237238,
-0.006353461,
-0.04705349,
-0.016226292,
-0.0024277451,
-0.026226535,
0.0124934185,
-0.0009048086,
-0.022369692,
0.0075139576,
0.0023106625,
-0.052866306,
0.025303649,
-0.0122661395,
0.005203295,
0.010227523,
0.0019938503,
-0.0012336734,
0.026901484,
0.012073298,
0.0041392194,
-0.03352699,
0.021364158,
-0.0020179555,
-0.03476669,
-0.007155822,
-0.009160004,
-0.0028840236,
0.020978473,
0.040634602,
0.0024053617,
-0.0014290983,
-0.021942684,
-0.0022039106,
0.006015987,
-0.016336488,
-0.021694744,
-0.027962115,
0.0058438065,
0.029229363,
-0.013981057,
-0.00027032342,
0.028154958,
0.003366129,
0.00083851913,
-0.0030286552,
-0.010365267,
0.0019904068,
-0.0043010693,
-0.021873813,
0.011598079,
0.008588364,
0.031267982,
0.028623288,
-0.020923376,
0.03451875,
-0.035730902,
-0.025358746,
-0.010585658,
-0.02574443,
0.015854381,
-0.0013335381,
0.006697822,
0.029008973,
-0.030634357,
-0.002412249,
-0.009545688,
-0.038100105,
-0.0006293198,
0.011784035,
-0.047687117,
0.0066909348,
-0.017576188,
0.003393678,
0.006460213,
0.004142663,
0.0047384077,
-0.0009960643,
-0.010558109,
0.016543103,
0.029670145,
-0.007610379,
-0.036557365,
0.0014876396,
0.01801697,
-0.025262326,
-0.015716637,
-0.021102443,
-0.004294182,
0.0034780465,
0.0116945,
-0.0027514447,
-0.6206212,
-0.016074773,
-0.020055586,
-0.017810352,
-0.0033712946,
0.021240188,
0.0005707784,
0.011632515,
0.000088242516,
0.01122617,
0.00012041875,
0.014463163,
0.0018251134,
-0.0124865305,
-0.0035400314,
-0.029642597,
0.0059953257,
-0.01699766,
0.021625873,
0.0023915872,
-0.017851675,
-0.0050517763,
-0.025344972,
0.008602139,
0.009180665,
0.013154591,
0.026667317,
0.011329478,
-0.0055717616,
0.012396997,
-0.015454923,
0.015689088,
-0.024876641,
0.0071971454,
0.041240677,
0.0053754756,
0.0061640623,
0.029615048,
0.025868401,
0.018044518,
0.004332062,
0.0039016104,
0.01684614,
0.005282498,
-0.002933956,
0.015096787,
0.0052205133,
0.007679251,
0.0063603483,
0.0022848353,
0.012073298,
0.013409418,
0.0070111905,
0.0022039106,
-0.00050319755,
0.022961993,
0.02071676,
-0.01397417,
0.026598446,
0.013498953,
-0.020950925,
0.024959287,
-0.015124337,
-0.014029268,
-0.010255071,
-0.0030889185,
-0.0320118,
-0.0012646659,
0.012335012,
0.026584672,
0.0005815397,
0.010509899,
0.00008146291,
0.020014264,
-0.016336488,
0.035372764,
0.0023984746,
0.035648253,
0.010750951,
0.006742589,
0.0026808507,
-0.009800515,
-0.009766079,
-0.024835318,
0.04413331,
-0.004218423,
-0.01947706,
0.019793872,
-0.024876641,
-0.017934322,
0.024394535,
0.008691672,
-0.019339316,
-0.02009691,
-0.025565363,
0.012025087,
-0.010633868,
0.0045111296,
0.008237116,
-0.032452583,
-0.00576116,
0.0017631284,
0.009063582,
0.010186199,
-0.011866681,
0.021915136,
-0.023127288,
0.00015259498,
0.026391828,
-0.030413967,
0.00078987813,
0.006129626,
-0.008409296,
-0.011549869,
-0.018223586,
-0.027962115,
0.023072189,
-0.011494772,
-0.021116218,
-0.02725962,
0.0063844533,
-0.011963102,
-0.008299101,
-0.018443977,
0.019297993,
0.00941483,
0.023237482,
-0.027438687,
0.0024552941,
-0.000121064426,
-0.00551322,
-0.0028581966,
0.019573482,
-0.026846386,
0.021350384,
-0.0111572975,
0.00065256417,
0.0036364524,
0.00758283,
-0.017190503,
-0.028540643,
-0.01355405,
0.0078720935,
0.007121386,
-0.027314717,
-0.009297748,
-0.013595373,
0.008457507,
0.012624275,
-0.01115041,
0.021019798,
0.013533388,
-0.033223953,
0.011177959,
0.014339194,
-0.011763372,
-0.026997905,
-0.028182507,
-0.01466978,
-0.025124582,
0.011846019,
0.0028168731,
0.02099225,
0.0085401535,
-0.0043974905,
-0.016405359,
0.026763739,
0.00015334827,
-0.013051283,
-0.029284462,
0.000021979919,
-0.012355674,
-0.029036522,
-0.01313393,
0.013292336,
0.025386294,
-0.0006590209,
0.0143805165,
0.0018010081,
0.012830892,
-0.013120155,
-0.018430203,
-0.0054099117,
-0.009662771,
0.004445701,
0.010441027,
0.029229363,
-0.0029563394,
0.02232837,
0.008581477,
0.01073029,
0.025579138,
0.010020906,
0.0035951291,
0.002465625,
0.001423072,
0.012025087,
-0.0012035418,
-0.005110318,
0.026570898,
0.010303282,
0.01479375,
0.013388757,
0.015565119,
0.006556634,
-0.035097275,
0.012300576,
-0.017906774,
0.0022039106,
0.00832665,
-0.020482594,
-0.0046798666,
0.011047102,
-0.010888696,
0.013078832,
-0.012307463,
-0.006632393,
0.006900995,
0.020964699,
-0.00815447,
0.00074640254,
0.019091375,
-0.0038602871,
-0.007975401,
-0.02170852,
0.014022381,
0.009855613,
0.011191733,
-0.0022331814,
0.008739883,
0.011480996,
0.024601152,
0.0039635953,
0.014600907,
-0.014132577,
0.010317056,
0.016708396,
0.008980935,
0.026543349,
-0.019490834,
-0.025978597,
0.022686504,
-0.0030286552,
-0.0054374607,
0.037604224,
0.008361085,
0.02911917,
0.023278806,
0.023857333,
0.031212883,
-0.025234776,
0.009607673,
-0.019725,
0.018664367,
0.007878981,
-0.010503012,
0.0051723025,
0.021322835,
0.040276468,
0.000075974654,
0.01362981,
0.006546303,
0.009497477,
-0.00733489,
-0.0079271905,
-0.0011493049,
0.012183493,
-0.004896814,
-0.021143768,
0.0048176106,
-0.0074726343,
-0.0018578278,
0.005575205,
-0.057577163,
0.002448407,
0.026970357,
0.0017769029,
0.037163444,
0.011239944,
0.008037386,
-0.010489237,
-0.055400804,
0.023127288,
0.022755377,
-0.022603858,
-0.015647765,
-0.012080185,
0.008726109,
0.022190625,
0.017975645,
0.012679373,
0.024422085,
0.0067219273,
0.035124823,
-0.01347829,
-0.01900873,
0.024091497,
-0.022879347,
0.0240364,
0.0008484195,
-0.0011906283,
0.008188905,
-0.0060125436,
-0.012768907,
0.044987325,
0.010647643,
0.0041943174,
0.0067907996,
-0.0008867296,
-0.049092107,
-0.005186077,
-0.0048176106,
0.0033024224,
0.011012666,
-0.014476937,
0.0015194931,
0.01516566,
-0.017080307,
0.004170212,
-0.01350584,
-0.03713589,
-0.042618122,
-0.0069251005,
0.010909357,
0.026378054,
0.033940222,
-0.015854381,
0.002307219,
0.019904068,
0.025758205,
0.0008243142,
-0.032976013,
0.010461688,
-0.019050052,
-0.0021677527,
0.000116114235,
0.02329258,
0.012672486,
-0.012245478,
0.033168856,
0.015234532,
-0.032948464,
0.007837657,
0.012520967,
0.004779731,
-0.0031474598,
0.00061081036,
0.06192989,
0.008987823,
-0.009228876,
0.0033385803,
0.009828064,
0.012741358,
-0.040028527,
-0.02168097,
0.0006073668,
0.0120182,
0.015757961,
0.023058414,
-0.011763372,
-0.0074864086,
-0.017879225,
0.009676545,
-0.017162954,
0.024807768,
-0.0046523176,
0.0071007246,
-0.0122661395,
-0.0073486646,
-0.021433031,
-0.0060676415,
0.01350584,
-0.0135471625,
0.0128791025,
0.02911917,
-0.024132822,
-0.03473914,
-0.022424791,
0.029697696,
-0.005372032,
-0.004438814,
-0.002562046,
0.00011320869,
-0.038540885,
-0.0025930386,
-0.02217685,
0.02906407,
-0.0060676415,
0.015151885,
-0.012727584,
-0.018678142,
-0.008987823,
-0.0077274614,
-0.021570776,
0.003490099,
-0.017589962,
-0.0382103,
-0.01429787,
0.030221123,
0.01281023,
0.0036398962,
-0.00022856964,
0.0069044386,
0.021433031,
-0.015151885,
-0.021653421,
0.01699766,
-0.02443586,
-0.0029752792,
0.0044766935,
-0.0015961133,
-0.024229242,
-0.041543715,
0.02425679,
-0.006742589,
-0.0053134905,
0.0141739,
0.008168244,
0.00023029144,
0.031598568,
0.0172456,
0.05201229,
0.0087605445,
0.004345836,
0.00007452188,
-0.03501463,
-0.026846386,
-0.016970111,
-0.0055166637,
-0.013237238,
-0.0021557,
0.01811339,
0.00072487997,
-0.005258393,
0.0036261217,
-0.0066289497,
-0.0064188894,
0.0091531165,
0.027300943,
0.03179141,
0.0022280158,
0.011081538,
-0.009132454,
-0.015937028,
0.00899471,
-0.03575845,
0.021019798,
-0.0060091,
-0.013368095,
0.022934444,
0.025014386,
-0.032204643,
0.0041805427,
0.015689088,
-0.0035193698,
0.022355918,
0.0034487757,
-0.020014264,
-0.012445208,
-0.0007976262,
-0.004824498,
0.0031164673,
-0.0137675535,
-0.010509899,
-0.013567825,
0.020317301,
0.008023612,
-0.0013025455,
-0.007403762,
-0.031130238,
-0.0067219273,
0.015565119,
-0.006442995,
0.01070274,
-0.005929897,
-0.013464516,
-0.024243016,
-0.02626786,
-0.0058506937,
-0.00609519,
-0.0005320378,
-0.005110318,
0.021598324,
0.036364526,
0.036089037,
-0.0022245722,
0.010303282,
0.025606686,
0.008691672,
-0.019146474,
-0.015399825,
-0.0012259253,
-0.013967283,
0.031157786,
0.011921779,
0.008829417,
0.021791166,
-0.014821298,
0.0009383838,
0.033582088,
0.014835073,
-0.023278806,
0.0132716745,
-0.057136383,
-0.01836133,
-0.011742711,
-0.01214217,
-0.0184853,
-0.040248916,
-0.0016959781,
0.027659077,
0.011184846,
0.0050070095,
0.0048554903,
0.020262202,
0.004018693,
0.029559951,
-0.0026378054,
0.013884637,
-0.012073298,
-0.024187919,
0.007617266,
0.001935309,
0.03030377,
0.0062880325,
-0.0018664368,
-0.011618741,
-0.03371983,
0.0064636567,
0.0018457752,
-0.012782682,
-0.0058093704,
-0.00650498,
-0.018072067,
0.009104906,
-0.013609148,
-0.0039394903,
-0.055814035,
0.015620217,
0.0019817976,
0.00060392317,
0.027342265,
-0.0061399573,
-0.00079590443,
0.03402287,
0.008058048,
0.03203935,
-0.01330611,
0.020055586,
0.018196037,
-0.008140694,
-0.039587744,
0.017824126,
0.0028495875,
-0.0060986336,
0.032397486,
0.026846386,
-0.013457629,
-0.028733484,
0.008367973,
-0.0037225427,
-0.010117327,
-0.01882966,
-0.013154591,
-0.010255071,
0.007892755,
-0.0049519115,
-0.0038912797,
0.0027893244,
0.03570335,
-0.010881809,
0.03746648,
-0.004004919,
-0.016281389,
-0.01684614,
-0.0026016475,
0.003949821,
0.0017106134,
-0.006639281,
-0.013967283,
0.017314473,
-0.0071627093,
-0.0005113761,
0.021694744,
-0.0061365133,
0.042590573,
-0.023692038,
0.004607551,
-0.0071076117,
0.017824126,
-0.016763495,
-0.0112123955,
0.009304635,
0.033141304,
-0.018072067,
0.003870618,
-0.006956093,
0.0037569788,
0.0050345585,
0.0064808745,
-0.0064533255,
-0.01935309,
-0.021102443,
0.006319025,
0.02366449,
0.01796187,
-0.0046764226,
-0.0035572494,
-0.011343252,
0.0036640014,
-0.019835195,
-0.034931984,
0.021529451,
-0.06066264,
-0.006088303,
-0.009772966,
0.018691916,
0.01172205,
0.020510143,
-0.010303282,
0.0038740616,
0.029780341,
-0.0051068743,
-0.0073280027,
0.007121386,
0.0141739,
-0.023389,
-0.0035400314,
0.018650593,
-0.02356807,
-0.012555403,
-0.008120033,
-0.0166533,
-0.009710981,
-0.030138478,
0.008953387,
0.011060876,
-0.03600639,
0.008016725,
-0.013423193,
0.027672851,
0.007465747,
-0.022851799,
0.013140817,
-0.024986837,
0.01318214,
-0.0022572866,
0.015041689,
-0.015523795,
0.006274258,
0.0011544704,
-0.029477304,
0.0025947604,
-0.028210055,
-0.01677727,
-0.013891524,
0.016763495,
0.011501659,
-0.014848848,
-0.0021884143,
-0.010709628,
0.008664124,
0.0008510022,
-0.02562046,
-0.0042631896,
-0.010441027,
0.016116096,
0.03203935,
-0.029615048,
-0.02648825,
-0.009834951,
-0.038816374,
-0.019490834,
-0.030083379,
0.005378919,
0.028430447,
0.0042907386,
-0.013016847,
-0.01362981,
-0.0031078584,
-0.019904068,
-0.030854749,
0.010082891,
-0.007610379,
0.021791166,
0.03223219,
-0.023650715,
0.023995077,
-0.007844544,
0.013684907,
0.0126587115,
0.009056695,
0.02596482,
-0.0054133553,
0.025083257,
0.0034263923,
-0.008223342,
0.00023631776,
0.018788338,
-0.016336488,
-0.03253523,
0.043554783,
-0.007865206,
0.004487024,
0.012445208,
0.012527854,
0.019545931,
0.024174144,
0.0046626483,
-0.031515922,
-0.02440831,
-0.008967161,
0.014352968,
-0.023816008,
0.026681092,
-0.01672217,
0.005337596,
0.004294182,
-0.013051283,
-0.036943052,
-0.008030499,
-0.011921779,
0.012355674,
0.019284219,
0.038871475,
0.0295875,
0.0018802112,
-0.023609392,
0.012734471,
-0.01516566,
-0.013808877,
-0.010344605,
0.024683798,
-0.0075139576,
-0.008987823,
-0.0053238217,
-0.0029856102,
-0.008505718,
0.005592423,
0.0109851165,
0.0010029515,
-0.040248916,
0.019270442,
-0.009531913,
1.3956038e-7,
-0.020909602,
0.0072660176,
-0.03250768,
0.011295042,
0.013030621,
-0.00028990893,
-0.013189027,
-0.0008875906,
0.0061124084,
-0.020551465,
-0.005912679,
0.0006671995,
-0.008505718,
-0.0057129497,
0.016405359,
0.20639622,
0.0010020906,
0.0065807393,
0.030028282,
-0.0040600165,
-0.022879347,
0.010323944,
-0.010213749,
-0.0012000982,
0.0030200463,
0.007438198,
-0.011177959,
-0.024959287,
-0.00012504609,
0.019614805,
0.0031095801,
-0.0039739264,
-0.022466114,
-0.019050052,
-0.02391243,
0.007624153,
-0.0024415196,
-0.00033359975,
-0.015523795,
0.028981425,
-0.00025073788,
-0.020523917,
-0.0014282374,
0.003543475,
0.012417659,
-0.028265154,
-0.0086228,
0.0023089407,
-0.0038017458,
0.013540275,
0.0045111296,
-0.0050862124,
-0.009077357,
-0.01677727,
0.014242772,
-0.01882966,
0.0012440042,
-0.009896936,
0.0004640265,
0.0032146103,
-0.003932603,
-0.0057370546,
-0.0061020777,
-0.002172918,
0.00011180972,
-0.045786243,
0.014063705,
0.009325297,
0.03991833,
-0.0029391213,
0.0018870984,
0.026639769,
0.021749843,
-0.0050070095,
0.018044518,
0.000106321466,
0.010048455,
-0.030909846,
0.011797809,
0.009132454,
0.017286923,
-0.01882966,
0.01355405,
0.04121313,
-0.019132698,
0.003984257,
-0.007142048,
-0.017920548,
-0.004383716,
-0.018967405,
-0.015303404,
0.026446927,
0.029642597,
0.0381552,
0.01684614,
-0.006935431,
0.007217807,
-0.036364526,
0.005664739,
0.0033799035,
-0.01040659,
0.029201815,
-0.0098762745,
-0.021570776,
-0.007672364,
0.011715163,
-0.0059057917,
-0.011969989,
0.0030355426,
-0.0035210915,
0.009435493,
-0.0034504975,
0.014600907,
-0.013464516,
-0.028898777,
-0.02614389,
0.05520796,
-0.00263264,
-0.0030699787,
-0.015757961,
0.0038981668,
0.0076654763,
0.009015372,
0.010792275,
-0.022824248,
0.023733363,
-0.033471894,
0.0040324675,
-0.0014626734,
-0.017893,
0.00993826,
0.014201449,
-0.028568191,
0.024959287,
-0.026433153,
0.004383716,
-0.031075139,
-0.0017622676,
0.032728072,
-0.022411015,
0.022851799,
-0.009717869,
-0.0077963336,
-0.02723207,
-0.026846386,
0.0038671743,
0.011708275,
0.015344728,
0.007424424,
0.009587011,
0.0059161223,
-0.013209689,
-0.015275856,
-0.015881931,
-0.02252121,
-0.007961627,
-0.0067563634,
-0.0024828431,
-0.00576116,
-0.013016847,
-0.02158455,
0.028485544,
0.0005195547,
-0.03228729,
-0.0004246402,
-0.028678387,
-0.0062467093,
-0.020041812,
-0.001458369,
-0.0079822885,
-0.037383832,
-0.01690124,
-0.03424326,
0.016281389,
0.035565607,
-0.018140938,
0.015317178,
0.02316861,
-0.0011140079,
0.0019439181,
-0.0011002335,
-0.17543128,
0.0027858808,
0.018499075,
-0.023719588,
0.017273149,
0.021543225,
0.0054030246,
-0.0022486774,
-0.007362439,
0.0039084977,
0.019174023,
0.017190503,
-0.041323323,
-0.03592374,
-0.010151763,
0.01882966,
-0.003207723,
0.021791166,
0.01466978,
-0.0013541997,
0.012961749,
-0.033141304,
0.022039106,
-0.0064223334,
0.012837779,
0.00028904804,
0.009779853,
-0.01362981,
0.0022039106,
-0.0023743692,
-0.005936784,
0.0013671133,
0.0073486646,
-0.020579016,
0.031515922,
0.008491943,
-0.007686138,
-0.0017476322,
0.0067184838,
0.009669658,
0.01615742,
0.022631407,
0.0016064442,
-0.015757961,
-0.013016847,
0.05823834,
0.018719466,
0.0072866795,
0.025262326,
-0.0047177463,
0.03377493,
-0.028265154,
0.036640014,
0.020551465,
0.016364036,
0.008478168,
-0.016198743,
0.020014264,
-0.034160614,
-0.021488128,
-0.0028719709,
-0.021157542,
0.03104759,
-0.0065290853,
-0.02257631,
-0.022342144,
0.009297748,
0.008319763,
-0.050194062,
0.013340546,
-0.016694622,
0.007389988,
-0.0060469797,
-0.0246287,
0.008884515,
0.018085841,
-0.0063465736,
0.013264786,
-0.012204155,
-0.005585536,
0.0006568687,
0.037273638,
-0.023485422,
-0.028926326,
0.016460458,
-0.002236625,
-0.023802234,
0.021295287,
-0.019366864,
0.009339071,
0.027025454,
-0.025262326,
0.028237604,
-0.008664124,
0.02292067,
0.030166026,
-0.00077438186,
-0.026667317,
-0.0072797923,
-0.0038947233,
-0.004497355,
0.008677898,
-0.012135283,
0.024697574,
0.04110293,
0.015992125,
0.017465992,
0.007892755,
0.044849582,
-0.0234441,
0.007624153,
-0.0119355535,
0.022989543,
0.0240364,
0.0086228,
0.015565119,
-0.012582952,
0.0027170086,
-0.0014988314,
-0.02490419,
0.051874544,
0.016019676,
-0.013574712,
-0.012541628,
-0.002519001,
-0.008361085,
-0.1207743,
-0.013443855,
-0.015578893,
0.009800515,
-0.011033327,
0.0036089036,
-0.0045490093,
0.03209445,
-0.007713687,
0.03129553,
-0.033196405,
0.011956215,
-0.008671011,
-0.014435614,
0.004700528,
0.011660065,
-0.013023734,
-0.010551222,
-0.009325297,
0.019132698,
-0.0027583318,
-0.00468331,
0.005895461,
-0.011363914,
0.021226414,
-0.002112655,
-0.040496856,
0.012796456,
0.012176606,
0.029008973,
-0.0054891147,
-0.019435737,
-0.001183741,
0.0039808135,
-0.00812692,
-0.011405237,
0.002360595,
-0.02465625,
0.04016627,
-0.003410896,
-0.014490712,
-0.0035124824,
0.0075070704,
-0.0124865305,
0.027066777,
-0.01578551,
-0.0004773705,
0.015138111,
0.007913416,
-0.00733489,
-0.019959165,
0.0045283474,
-0.04146107,
-0.003818964,
-0.0047315205,
-0.016970111,
0.0025413844,
0.0143254185,
-0.028733484,
0.00037169468,
-0.008560815,
0.0017906773,
-0.012899764,
-0.0021763616,
0.014573359,
-0.025937272,
-0.0154136,
-0.032397486,
0.024243016,
-0.028761033,
0.0024449632,
0.026322957,
-0.011556756,
0.0005763743,
-0.014931494,
-0.0056957314,
-0.023981303,
-0.018375104,
-0.0019508052,
-0.026157664,
-0.017562412,
-0.021474354,
0.022121752,
-0.014959043,
0.028540643,
-0.01479375,
-0.010461688,
0.0049450244,
0.008650349,
-0.021446805,
0.01214217,
0.030551711,
0.002042061,
-0.014642231,
-0.015675314,
0.0060469797,
-0.022975767,
-0.01615742,
0.034904435,
0.001510884,
-0.01836133,
-0.009077357,
-0.06754986,
0.026929032,
-0.010199973,
-0.0005049194,
0.021694744,
-0.0071007246,
0.0029615047,
-0.011074651,
-0.0072591305,
0.0112123955,
-0.0160059,
0.012011313,
-0.0141739,
-0.035372764,
-0.020248428,
-0.008175131,
0.039863233,
-0.020289753,
0.013016847,
0.01699766,
-0.008312875,
-0.029229363,
0.011625628,
0.013946622,
0.0240364,
-0.0022521212,
0.0030768658,
0.027245844,
-0.015881931,
-0.013574712,
-0.0039050542,
-0.029890537,
-0.02478022,
-0.010082891,
-0.021942684,
-0.019050052,
0.0073280027,
0.0057439418,
0.02465625,
0.011625628,
-0.013195914,
-0.035042178,
0.0142152235,
0.0043423926,
-0.011308816,
0.018526623,
-0.021997783,
0.0051378664,
0.013795103,
-0.010723403,
0.056971088,
0.006081416,
0.0044560316,
-0.033885125,
-0.018540397,
0.00008237761,
0.005496002,
-0.00096162816,
-0.0074450853,
-0.010930019,
0.03771442,
0.011887343,
0.028788581,
0.014807524,
-0.014807524,
0.012947975,
-0.006108965,
-0.004004919,
0.0009435492,
-0.042838514,
-0.02809986,
0.020895828,
0.0074795214,
0.008016725,
0.00015732995,
-0.021625873,
-0.032149546,
-0.011625628,
-0.0016460457,
0.0025482716,
0.009848725,
-0.004046242,
0.012603614,
-0.00807871,
0.025441393,
-0.0007085228,
-0.016240066,
0.016832367,
0.004146107,
0.013946622,
0.018443977,
0.024366986,
0.016749721,
0.0073555517,
0.006625506,
0.030772101,
-0.009304635,
0.003259377,
0.008547041,
0.020193331,
-0.013581599,
-0.0075690555,
-0.001387775,
-0.014146351,
-0.012527854,
0.051351115,
-0.013526501,
-0.02133661,
0.0015435984,
-0.007947853,
0.0107785,
-0.007961627,
0.0063155815,
0.018347556,
-0.01612987,
0.004211535,
-0.0012207598,
-0.0020919933,
0.015468697,
0.017879225,
0.014628457,
0.011419011,
0.011942441,
0.028113635,
0.018526623,
0.009807402,
0.024243016,
-0.016873691,
-0.0075759427,
-0.023278806,
0.031488374,
-0.001785512,
-0.04653006,
-0.006787356,
-0.0051998515,
-0.01429787,
0.02068921,
0.016749721,
-0.032976013,
0.08529134,
0.01736957,
0.005423686,
0.00845062,
-0.043912917,
0.013216577,
0.023223707,
-0.0015651209,
-0.017204277,
-0.023953753,
0.044684287,
-0.024229242,
0.005592423,
-0.02326503,
-0.017879225,
0.008912063,
-0.014504487,
0.006625506,
-0.010930019,
-0.014959043,
0.0073831007,
-0.028457996,
0.0059849946,
0.013650471,
-0.01969745,
-0.0008015003,
0.008223342,
-0.007176484,
-0.0057301675,
-0.001714918,
0.034133065,
-0.0067357016,
-0.03300356,
-0.0038740616,
0.024146596,
-0.020482594,
-0.006759807,
0.0029046852,
0.031929154,
0.033609636,
-0.0145458095,
-0.012300576,
0.005740498,
-0.023650715,
0.016088547,
-0.0078169955,
0.008429958,
0.0022314594,
-0.0018595495
] |
We develop a reversible jump Markov chain Monte Carlo approach to estimating the posterior distribution of phylogenies based on aligned DNA/RNA sequences under several hierarchical evolutionary models. Using a proper, yet nontruncated and uninformative prior, we demonstrate the advantages of the Bayesian approach to hypothesis testing and estimation in phylogenetics by comparing different models for the infinitesimal rates of change among nucleotides, for the number of rate classes, and for the relationships among branch lengths. We compare the relative probabilities of these models and the appropriateness of a molecular clock using Bayes factors. Our most general model, first proposed by Tamura and | [
-0.01594579,
-0.0051857606,
-0.021594385,
-0.01272285,
-0.0017398479,
0.00095184887,
0.004567523,
0.011135027,
-0.017432263,
-0.012844469,
-0.020567369,
0.028134862,
0.005739809,
0.01190529,
0.0149458,
-0.0029560523,
0.029134853,
0.0017271792,
0.002415517,
0.007831005,
-0.018810628,
0.030540245,
-0.0013690746,
-0.044486053,
0.013040414,
0.036702346,
0.020634934,
-0.025621373,
-0.0142701315,
0.0014180605,
0.022580862,
0.0075201974,
-0.022770049,
-0.032945625,
-0.02293221,
-0.014364725,
0.0055371085,
-0.01298636,
0.0028715937,
-0.02168898,
0.0050337347,
0.0094999075,
-0.014648506,
-0.02129709,
0.009662068,
-0.019432243,
0.023026804,
-0.014148511,
-0.008574241,
0.0052330573,
0.027310545,
0.0011765088,
-0.012871496,
0.0019425487,
-0.011621509,
0.00027744664,
0.0029307147,
0.009682339,
-0.016445786,
0.0011705967,
-0.012013397,
0.01106746,
-0.039296914,
0.0032921978,
-0.018621441,
-8.544839e-7,
-0.014621479,
0.0009898553,
0.004979681,
0.022107894,
0.03367535,
0.01854036,
-0.01766199,
-0.001749983,
0.02448625,
-0.0042972555,
0.0021080875,
-0.0053242724,
-0.029351067,
0.037405044,
0.012574202,
0.0068580415,
0.010574222,
-0.0010836043,
0.010824219,
-0.004905358,
0.0022043705,
0.022634916,
-0.013155278,
-0.010702599,
0.045648206,
0.025337592,
0.00369591,
0.014094458,
-0.04318877,
-0.01298636,
-0.01954035,
0.018905222,
0.012999874,
-0.032215904,
-0.023864632,
0.016472813,
-0.0068479064,
-0.013580949,
-0.00061063597,
-0.009702609,
0.010533681,
-0.027918648,
0.0068783117,
-0.015405255,
-0.030215923,
0.039215837,
-0.0028614588,
-0.022229513,
0.017364696,
-0.017743072,
0.025310565,
0.020743042,
0.0092836935,
-0.0046080635,
0.01378365,
-0.008689105,
0.013270142,
-0.003881719,
0.035134792,
0.020526828,
-0.011594482,
-0.0140539175,
-0.007716141,
-0.0024493006,
0.009128289,
0.01478364,
-0.013398519,
0.034215882,
-0.047459,
0.032215904,
0.0041722567,
-0.013303925,
-0.01562147,
-0.020121425,
0.0009780311,
0.023621392,
-0.0021435602,
-0.009574232,
0.012439068,
0.035864517,
0.008635052,
0.03199969,
0.00035134793,
-0.024837596,
0.008844509,
-0.010236387,
0.0049087363,
-0.003353008,
0.014918774,
0.013135008,
0.0008424749,
0.00837154,
-0.01833766,
-0.017202536,
-0.00831073,
-0.00082178257,
0.00422631,
0.008364784,
0.030756459,
0.016256599,
-0.0052263006,
-0.009898553,
-0.003381724,
-0.016932268,
-0.009520178,
0.025553806,
-0.017689018,
0.0038749625,
-0.00018739261,
0.007648574,
0.0075201974,
0.003342873,
-0.025634887,
-0.023918686,
0.00824992,
0.0020692367,
0.01782415,
0.011499888,
-0.00551346,
0.008729645,
0.021770058,
-0.0072093895,
0.028026754,
-0.020634934,
0.013655272,
0.0014645128,
-0.008445864,
0.020040346,
-0.6373992,
-0.0112769175,
0.003499966,
-0.023270044,
0.030378083,
0.020810608,
0.0016503218,
0.023688959,
-0.0057735927,
0.035080742,
-0.014905261,
0.002805716,
0.032621305,
-0.019310623,
-0.03208077,
-0.048891418,
0.012337718,
-0.037107747,
-0.0044898214,
-0.0045303614,
-0.05237787,
0.012837714,
0.018310633,
0.011270161,
-0.0032432117,
0.006060752,
0.02572948,
0.0053107594,
0.0038884757,
-0.00024091826,
-0.024972731,
0.017026862,
-0.010628276,
0.00510468,
0.042567153,
-0.017797124,
-0.0065843957,
0.025067324,
0.018161986,
0.017148482,
-0.03135105,
-0.031540234,
0.026513256,
0.026986225,
-0.03164834,
0.021810599,
0.0044898214,
0.0020861283,
0.01031071,
-0.015689036,
0.016756594,
-0.00070607424,
-0.017107941,
-0.005202652,
-0.0029492956,
-0.0115201585,
0.013675543,
-0.039486103,
0.026594337,
-0.011662049,
-0.01649984,
-0.0020118048,
0.0033479405,
-0.017851178,
-0.03783747,
0.0016080925,
-0.006567504,
0.006185751,
0.008202623,
-0.025621373,
0.00835127,
0.012074207,
-0.0046891435,
-0.020607907,
0.006543855,
0.021080876,
0.01280393,
-0.003577668,
-0.01841874,
0.0029256472,
0.011080974,
-0.0062060207,
-0.01929711,
-0.021837626,
0.038296927,
-0.00027174567,
-0.0037600987,
0.0118444795,
0.005114815,
0.0094188275,
0.0030286869,
0.007675601,
-0.011236377,
-0.026134882,
-0.0140809445,
0.009939092,
-0.009182343,
0.0026722713,
0.013418789,
-0.049080603,
-0.013601219,
0.0093647735,
0.023121398,
0.01970251,
-0.004831034,
-0.00822965,
0.014770127,
-0.0014830937,
0.03232401,
-0.0071620927,
-0.0018462659,
-0.029405119,
0.0027584191,
-0.0032736168,
0.012249881,
-0.04175635,
0.020634934,
-0.002209438,
-0.0045506316,
-0.031053752,
-0.0012187382,
0.011249891,
0.009722878,
-0.019891698,
0.00082178257,
0.024715977,
-0.005709404,
-0.038134765,
-0.020594394,
0.0030844295,
-0.008331,
-0.006317506,
0.026107855,
-0.02113493,
0.012222854,
-0.004334417,
0.029378094,
0.011290431,
-0.017864691,
-0.027891621,
-0.033296973,
0.016567407,
-0.0070742555,
-0.007506684,
-0.037242882,
-0.022080867,
-0.014959314,
0.006344533,
0.02485111,
0.021553844,
0.017364696,
0.010432331,
-0.017553883,
-0.0026587578,
0.019905211,
-0.006442505,
-0.017540371,
-0.04491848,
-0.020499801,
-0.02760784,
-0.000098869394,
0.01941873,
-0.021161957,
0.02481057,
0.0029070664,
-0.008540458,
0.012553932,
0.016770108,
-0.01570255,
-0.013999864,
0.004868196,
-0.029107826,
0.00049492763,
0.004391849,
-0.010756652,
0.0050236,
0.0074526304,
-0.0065472336,
-0.020797096,
-0.01929711,
0.008128299,
-0.0118444795,
-0.0022550456,
0.008729645,
0.037405044,
0.0069087166,
0.022756536,
0.0012153598,
0.0020557232,
0.017486317,
0.011459348,
0.007824249,
-0.018189013,
0.015107961,
0.009405314,
-0.0066823675,
0.02652677,
0.014972827,
-0.004067528,
0.034945607,
0.0026232854,
0.015378229,
0.02229708,
-0.0140809445,
-0.007871545,
-0.023594365,
0.026040288,
-0.006209399,
0.027702434,
0.008655322,
-0.009817473,
-0.013891757,
-0.040134747,
-0.030918619,
0.015905252,
0.016932268,
-0.024256522,
0.027161898,
0.021459252,
0.019351164,
-0.015905252,
0.010040443,
0.04294553,
0.00028399218,
-0.0035675329,
-0.0139187835,
0.0040607713,
0.017689018,
0.005581027,
-0.009560718,
0.014040404,
0.012209341,
-0.031945635,
0.008297217,
0.035864517,
0.005358056,
0.0073445234,
0.007540467,
0.035864517,
0.01102692,
-0.0035540196,
-0.00087076856,
-0.009695852,
0.0022111272,
0.0352429,
0.013520139,
0.026161907,
0.0021249794,
-0.013560679,
0.0035911812,
-0.02033764,
-0.0023040317,
-0.010614762,
0.02485111,
0.016094439,
-0.02972944,
0.015189041,
0.017324155,
0.032351036,
0.027337572,
0.00061063597,
0.021067362,
0.0035371277,
-0.021621412,
0.017729558,
-0.039053675,
0.0068242582,
-0.021810599,
-0.0066891243,
0.009918823,
-0.017486317,
-0.01985116,
0.007506684,
-0.0039121243,
0.011560699,
-0.014621479,
0.009648555,
0.015770117,
0.029242959,
-0.0011072528,
-0.015689036,
-0.03891854,
0.036918562,
0.013878244,
-0.0141620245,
-0.01874306,
-0.008324243,
-0.003793882,
-0.02972944,
0.013891757,
0.000862745,
0.0065810173,
0.014364725,
-0.028269995,
-0.0140809445,
-0.014729586,
0.03491858,
-0.011810696,
0.00373645,
-0.009506664,
-0.008939102,
-0.012324205,
-0.002268559,
-0.0039796913,
0.026161907,
0.0005996563,
-0.014472832,
-0.0040607713,
0.007993165,
0.0027888243,
-0.0039290157,
-0.020513315,
-0.013297169,
-0.019148463,
0.008216136,
0.0020219397,
-0.007128309,
-0.0022702483,
0.031729423,
0.0062533175,
-0.0073850635,
-0.008020192,
-0.028188916,
0.01662146,
0.05832376,
0.023148423,
-0.01486472,
-0.004135095,
-0.0141349975,
0.0013107981,
-0.008520188,
-0.0028631478,
0.013236358,
-0.020675475,
-0.0138647305,
0.010283684,
-0.005287111,
0.02572948,
0.004391849,
0.02636461,
-0.0069661485,
-0.027013252,
-0.003824287,
0.001027017,
-0.017702531,
-0.0057735927,
0.016553894,
0.03459426,
0.00032453233,
0.0060134553,
0.027432166,
0.019486297,
-0.0027212573,
-0.01749983,
-0.008472891,
0.016107952,
-0.00024408547,
0.034269936,
0.016270112,
0.0058039976,
-0.010175576,
-0.00806749,
0.0020844392,
-0.007364793,
0.0138647305,
0.015540389,
0.000378797,
0.007885058,
0.005709404,
-0.006070887,
0.008729645,
0.006236426,
0.007675601,
-0.010466115,
0.036188837,
-0.02154033,
-0.04370228,
-0.009783689,
0.0139187835,
0.0050236,
-0.003353008,
0.0031486182,
-0.014391752,
0.0014982963,
-0.030378083,
-0.027783513,
0.02840513,
-0.0050100866,
0.002297275,
-0.002160452,
-0.023513285,
0.0032195633,
-0.039810423,
-0.026215961,
-0.018364687,
-0.029918628,
-0.03399967,
-0.021513304,
0.013797163,
0.024256522,
0.000049962564,
0.0040709064,
0.003608073,
0.03199969,
-0.014107971,
0.003195915,
-0.011486375,
-0.04586442,
0.00929045,
0.02313491,
-0.011357998,
-0.0113850245,
0.0046823868,
-0.01566201,
0.010608005,
0.01014855,
0.02932404,
-0.007303983,
-0.008256677,
0.027297033,
0.012999874,
0.025270024,
-0.0071823625,
-0.014594452,
0.0035506412,
-0.012560689,
-0.001129212,
-0.024972731,
-0.0052263006,
-0.020959256,
-0.021513304,
-0.0072431727,
0.0096080145,
-0.022702482,
0.017189022,
-0.020486288,
0.010445844,
0.01566201,
0.017932259,
0.031432126,
0.0061823726,
0.002844567,
-0.01749983,
0.009675582,
0.016972808,
0.01629714,
0.026905144,
0.010986379,
-0.017175509,
0.012439068,
-0.010398548,
0.0023834228,
0.0017195779,
-0.006628314,
-0.00086485647,
0.036134783,
0.026986225,
-0.03708072,
-0.01198637,
-0.009162073,
0.004584415,
0.008736402,
-0.023905173,
-0.015445796,
0.0049999515,
-0.005131707,
-0.0050911666,
0.010932326,
0.022688968,
-0.0294862,
-0.013682299,
0.02229708,
0.0046215765,
0.012026911,
-0.024594355,
-0.020864662,
-0.033269946,
-0.021959247,
0.008418838,
-0.017972799,
0.013378249,
-0.0027398383,
0.020594394,
0.017040376,
0.011053947,
-0.02058088,
0.0010346184,
0.01966197,
0.013391762,
-0.011330971,
0.009405314,
0.015378229,
-0.018797114,
-0.01574309,
0.019189002,
-0.0053715697,
-0.0116823185,
-0.0013141765,
0.018297119,
0.019351164,
-0.0019932238,
-0.021553844,
-0.008081002,
-0.046513062,
-0.018256579,
0.008358027,
-0.008655322,
-0.0064898017,
-0.014337699,
-0.011256647,
0.025229484,
0.0028496345,
0.03932394,
-0.0064965584,
0.026756497,
-0.003079362,
0.016783621,
-0.014283645,
0.027432166,
-0.011857993,
-0.010830976,
-0.025526779,
0.006368181,
0.012026911,
-0.000057748595,
0.01654038,
-0.007858031,
-0.013162035,
0.013026901,
0.0045303614,
-0.015189041,
0.0029560523,
0.01286474,
0.016959295,
-0.007398577,
-0.023337612,
-0.0003574712,
-0.021432225,
0.0046080635,
0.02897269,
0.012526905,
-0.000121726014,
-0.021040335,
0.0022651807,
0.031107806,
-0.0005945888,
0.032972652,
0.004651982,
0.023634905,
0.02377004,
-0.0073174965,
-0.041594192,
-0.015283635,
-0.0068242582,
0.026215961,
0.0136214895,
0.03491858,
-0.008412081,
-0.009810716,
0.019999806,
0.024121387,
-0.014486345,
-0.03351319,
0.020202506,
0.00070016214,
-0.006594531,
-0.006645206,
0.0139187835,
-0.0076620877,
0.02245924,
-0.016553894,
0.027202439,
-0.014432292,
-0.024040308,
-0.0016080925,
0.03032403,
0.010891786,
0.026742984,
-0.012303934,
-0.028053781,
0.015026881,
0.003255036,
-0.01574309,
-0.00040033396,
0.006912095,
0.03943205,
-0.00057009584,
-0.011182324,
-0.0059087262,
-0.0063377763,
-0.0028428778,
0.00018411984,
-0.013148521,
0.03943205,
-0.033621296,
0.0003973779,
-0.039810423,
0.01390527,
0.0027229465,
0.019675484,
-0.014013377,
-0.033702374,
-0.010195847,
0.03040511,
0.032107797,
0.015364716,
0.0076688444,
-0.008594511,
-0.00018644244,
0.013080954,
-0.03748612,
-0.009621528,
-0.0059864284,
-0.046918463,
-0.006364803,
-0.013560679,
0.026905144,
0.022824103,
-0.0043141474,
-0.013695813,
-0.008344513,
0.012276907,
-0.02677001,
0.023270044,
0.021634925,
-0.021472765,
-0.033972643,
-0.008128299,
-0.019621432,
-0.009276937,
0.005054005,
-0.017837664,
-0.022161948,
-0.013736353,
-0.015324175,
0.0119255595,
0.010878272,
-0.030053763,
-0.007722898,
0.00037710782,
-0.0005481366,
0.003146929,
-0.040296905,
0.007060742,
-0.0065843957,
-0.002660447,
0.009263423,
-0.013709326,
0.02932404,
0.0029813899,
-0.00084120804,
-0.0063715596,
-0.01933765,
-0.03351319,
-0.021107903,
0.019080896,
-0.009756662,
-0.007222903,
0.0039155027,
-0.0077566816,
-0.010533681,
0.023986254,
-0.0023834228,
-0.0048344126,
-0.0028732829,
0.012675553,
0.0051013017,
0.006854663,
-0.003530371,
0.00053589005,
0.022418702,
0.015634984,
-0.036053702,
-0.009080993,
-0.0069053383,
0.05681026,
0.03381048,
-0.008540458,
-0.02764838,
-0.014432292,
-0.042810395,
-0.028756477,
-0.015526876,
0.005797241,
0.0017550505,
0.010986379,
0.017337669,
0.009621528,
-0.00023690649,
0.005182382,
0.0010743139,
-0.0019104544,
0.015297148,
0.000012503838,
0.019716024,
0.029459173,
-0.025107864,
-0.007303983,
0.008972886,
-0.0039560427,
-0.024526788,
-0.00012542108,
-0.013020144,
0.004537118,
0.013553922,
0.0053715697,
0.017567396,
0.0008023571,
0.022607889,
-0.027621353,
-0.017513344,
0.021310603,
-0.016432272,
-0.02560786,
-0.017189022,
-0.0139187835,
0.0021520061,
0.021905193,
-0.037567202,
-0.015513363,
0.012607986,
-0.02025656,
0.0009864769,
0.009317477,
0.004510091,
0.020107912,
0.0031418614,
-0.03367535,
-0.007817492,
-0.012675553,
-0.023351125,
0.0093377475,
0.008060733,
-0.0070810122,
-0.0054492713,
-0.011668806,
0.005378326,
-0.009817473,
-0.00136823,
0.0033209138,
-0.0050100866,
-0.025040297,
0.003255036,
0.028756477,
-0.0027026765,
0.0036823966,
0.0073512797,
-0.0114120515,
0.0027803783,
-0.015648497,
0.014202565,
-0.012412041,
0.031134833,
0.012662039,
-0.014499859,
0.0018901844,
0.018648468,
-0.013209331,
-0.021418711,
-0.0044154976,
0.19232246,
-0.041891485,
-0.0066654757,
0.020107912,
0.0243376,
-0.0070945257,
0.0031807125,
0.010364764,
-0.0009814093,
0.016783621,
0.0243376,
0.009810716,
0.0052938676,
0.0063985866,
0.013479599,
-0.035999652,
-0.018202526,
-0.020134939,
-0.02117547,
0.010317467,
0.006361425,
0.0014628236,
-0.011635022,
-0.010905299,
0.013891757,
-0.015959304,
-0.03767531,
0.010479628,
-0.005202652,
0.011202594,
-0.033296973,
0.0055371085,
0.010858003,
0.0072296597,
-0.028999718,
-0.0026232854,
0.025837587,
-0.015594443,
0.00009623006,
-0.007439117,
0.009479637,
-0.013607976,
0.012621499,
-0.017364696,
-0.0019205895,
0.0075201974,
0.014067431,
-0.008858022,
-0.007682358,
-0.0035168577,
-0.038864486,
-0.027418653,
-0.0022854507,
-0.0033445621,
0.0019290353,
-0.020188993,
0.0018209283,
0.010297197,
0.020188993,
0.0054526497,
-0.012107991,
-0.0134052755,
-0.02225654,
0.017432263,
-0.04110771,
0.013574192,
-0.007020202,
0.0017753206,
0.017432263,
-0.0091891,
0.0111958375,
-0.022148434,
-0.009432341,
0.0019172111,
-0.007844518,
-0.02556732,
0.052675165,
0.01854036,
0.036783427,
0.0090945065,
0.0070066885,
-0.010729626,
-0.013999864,
-0.018189013,
-0.00924991,
-0.043161742,
0.036540184,
-0.00690196,
-0.0066249357,
-0.0034239532,
0.012952577,
-0.011898533,
-0.003217874,
-0.0020101157,
-0.002415517,
0.009675582,
-0.0046283333,
0.010135037,
0.004118203,
-0.003773612,
-0.014189051,
0.05254003,
0.020918716,
-0.0018597792,
-0.0030776728,
-0.0011815764,
-0.0065911524,
0.013222844,
0.0147431,
-0.008844509,
-0.013263385,
-0.02193222,
0.015243095,
-0.0128242,
0.0026824065,
-0.004037123,
0.0047330623,
-0.015324175,
0.030621324,
-0.0139187835,
0.013256628,
-0.027864594,
-0.012689066,
0.033351026,
0.015324175,
0.0036722617,
0.008222893,
-0.00044129638,
-0.010601249,
-0.009040453,
0.02185114,
-0.0036148299,
0.0015058975,
0.015270122,
-0.0010379967,
-0.016959295,
-0.024080846,
-0.032134824,
-0.024229495,
-0.013486356,
0.0046688737,
0.011080974,
-0.005503325,
0.009013426,
0.007898572,
-0.01833766,
0.03910773,
0.013209331,
-0.003138483,
0.002111466,
-0.0072701997,
0.0042060404,
-0.013297169,
0.00049281615,
0.0023158558,
-0.01194583,
-0.0032077392,
-0.033567242,
-0.0020286965,
0.00635129,
-0.025161918,
0.016756594,
0.02881053,
0.018648468,
0.007858031,
0.000034337714,
-0.17134969,
-0.007303983,
0.033648323,
-0.027864594,
0.03656721,
0.020891689,
0.049053576,
0.0060945353,
-0.019486297,
-0.009817473,
0.017364696,
0.0068377713,
-0.03316184,
-0.02509435,
0.020634934,
0.015067421,
-0.007439117,
0.028026754,
0.0017077536,
-0.002962809,
0.018445767,
-0.04275634,
0.023580853,
-0.015837684,
-0.007993165,
0.021837626,
-0.0028614588,
0.016364707,
-0.017972799,
-0.033107787,
-0.021391684,
-0.0008458533,
0.014040404,
-0.015486336,
0.0042296886,
0.013324195,
0.019405218,
0.0027753108,
-0.000062974475,
0.008533701,
0.01654038,
0.040080693,
0.0038580706,
-0.0057465658,
-0.002092885,
-0.0092296405,
0.009006669,
0.0009856323,
0.004368201,
-0.0016562339,
-0.0075539807,
-0.02213492,
0.023148423,
0.00324659,
0.004057393,
-0.017107941,
-0.022824103,
0.020540342,
0.018040365,
-0.036783427,
-0.013121494,
-0.0008082692,
0.012249881,
0.0035641545,
-0.0028479453,
-0.023310585,
-0.03081051,
0.0023884904,
-0.022526808,
-0.0053512994,
-0.008243163,
0.0034729391,
0.0067600696,
-0.00020607909,
0.008162083,
0.007824249,
-0.015418769,
0.018891709,
-0.02301329,
-0.020364666,
-0.012912037,
0.021445738,
-0.015878225,
-0.006540477,
0.015121475,
-0.008918832,
0.009736392,
0.005506703,
-0.029026745,
-0.0019797105,
0.012837714,
-0.034269936,
0.020040346,
-0.0019256569,
0.019716024,
0.020351153,
0.021188984,
-0.013675543,
0.0352429,
-0.000226138,
0.003969556,
0.010709356,
-0.009797202,
0.040810414,
0.02689163,
-0.012290421,
-0.027580813,
-0.0073580365,
0.023986254,
-0.015797144,
-0.00741209,
-0.004898601,
0.0181755,
0.009195857,
-0.037215855,
0.037783418,
-0.021161957,
-0.023405178,
0.007439117,
0.0000431003,
0.071080394,
-0.0012964401,
-0.005915483,
0.008675591,
0.012540419,
-0.018702522,
-0.1285393,
-0.025580833,
0.00037161802,
0.009999903,
-0.008608025,
0.023648418,
-0.008331,
0.020202506,
-0.028999718,
0.033324,
-0.019932238,
-0.016999835,
-0.0066992594,
-0.007925599,
0.0039290157,
-0.000077490804,
0.019797105,
-0.012182314,
-0.011101243,
0.02001332,
-0.001378365,
-0.039242864,
0.0008521877,
0.011560699,
0.008317486,
0.0053512994,
-0.01482418,
0.0073783067,
0.011999884,
0.01782415,
-0.0021739653,
-0.0068479064,
-0.014013377,
-0.0057060258,
-0.011695832,
0.009709365,
-0.010797192,
-0.0029087556,
0.026337583,
-0.00092735584,
-0.012499878,
0.0017398479,
0.014878234,
0.00096536224,
0.0022516672,
0.0027263248,
-0.011189081,
0.011040433,
-0.01778361,
-0.008797212,
-0.009797202,
-0.00737155,
-0.018445767,
-0.019986292,
0.0070269587,
-0.007655331,
-0.013074197,
0.0185809,
-0.005249949,
-0.009047209,
-0.014837693,
0.0057634576,
-0.011878263,
0.009412071,
0.015567416,
-0.013797163,
-0.002543894,
-0.018878195,
0.022540322,
-0.006344533,
0.0006807366,
0.015270122,
-0.0058208895,
0.0025202457,
-0.024824083,
-0.020229533,
-0.03616181,
-0.009709365,
0.0032617927,
-0.013547165,
-0.0057364306,
-0.017107941,
0.008858022,
-0.0046553602,
0.0019999805,
0.01214853,
-0.004516848,
-0.017594423,
-0.0011950898,
-0.013486356,
-0.0034763175,
0.030945646,
-0.016634973,
-0.019688997,
-0.008533701,
0.01558093,
0.00022402655,
-0.003618208,
0.027945675,
0.009567475,
-0.020040346,
0.0057229176,
-0.050837345,
0.04010772,
-0.013378249,
-0.042404994,
0.013080954,
-0.008486404,
0.01933765,
-0.0048175207,
0.007851275,
0.022324108,
-0.031188887,
0.015134988,
-0.014567426,
-0.028540263,
-0.02021602,
-0.013520139,
0.012249881,
-0.026229475,
0.024080846,
0.007614791,
-0.0078039784,
0.0028986204,
0.009675582,
0.021229524,
-0.013736353,
-0.0241349,
-0.0047769807,
0.044161733,
-0.020797096,
-0.0028986204,
0.004097933,
-0.019594405,
0.003587803,
0.006219534,
-0.012182314,
-0.006979662,
-0.0015227892,
0.024324087,
0.030269977,
0.048215747,
-0.0005612277,
-0.048621148,
-0.017810637,
-0.010628276,
-0.014067431,
-0.0074864137,
-0.014432292,
0.01308771,
0.008276947,
-0.01658092,
0.04918871,
0.0063006147,
-0.022486268,
-0.026540283,
-0.012749876,
0.0007715297,
0.0119661,
-0.006483045,
0.0055168383,
-0.015405255,
0.043540116,
0.016729567,
-0.00005405353,
0.020270074,
-0.010243144,
-0.01566201,
-0.020148452,
-0.0026266638,
0.019621432,
-0.027783513,
-0.013121494,
0.008331,
0.0012829268,
0.0030574028,
0.0074458737,
-0.0056080534,
-0.025161918,
-0.0019999805,
-0.011209351,
0.036026675,
0.008547214,
-0.009439098,
-0.012351232,
0.008425593,
0.018310633,
0.0053411643,
0.023188964,
0.0019898457,
-0.0006891825,
0.018837655,
0.014499859,
0.019161977,
0.018607927,
0.0117093455,
-0.015553903,
0.03008079,
-0.00095184887,
-0.022715995,
0.010790436,
0.033540215,
-0.010141794,
-0.01670254,
0.006101292,
-0.022594376,
-0.01298636,
0.009398557,
-0.012641769,
-0.025513265,
0.012155287,
0.003942529,
0.020472774,
0.010635031,
-0.004898601,
0.016013358,
-0.011810696,
0.030053763,
-0.0061823726,
-0.022715995,
-0.015540389,
0.0061148056,
0.020675475,
0.013155278,
0.015324175,
0.013466085,
0.0042060404,
0.028026754,
0.027107844,
-0.02872945,
0.04437795,
0.0011511713,
0.004067528,
0.021418711,
0.006675611,
-0.023040317,
-0.012526905,
-0.015770117,
0.0075607374,
0.010648545,
-0.019067382,
0.07032364,
0.016756594,
0.0074729,
0.004979681,
-0.03535101,
0.013216088,
0.041999593,
-0.0018614684,
-0.0013749866,
-0.015324175,
-0.0018884952,
0.000049223552,
-0.0023411934,
-0.037621256,
0.0012559,
0.011959343,
-0.0077566816,
0.025472725,
-0.0241349,
-0.03575641,
0.01478364,
0.0023192342,
0.03318887,
0.01380392,
-0.03008079,
-0.0006938277,
0.0013454261,
-0.011013406,
0.0068175015,
-0.03299968,
0.016189031,
0.01292555,
-0.04067528,
-0.0041992837,
0.002317545,
0.006459397,
-0.0097161215,
0.00602359,
0.03137807,
0.010358008,
0.013560679,
-0.003234766,
-0.012128261,
-0.04110771,
-0.013189062,
0.023472745,
0.0009797203,
-0.0143782385,
-0.010999893
] |
The average lifespan of humans is increasing, and with it the percentage of people entering the 65 and older age group is growing rapidly and will continue to do so in the next 20 years. Within this age group, cardiovascular disease will remain the leading cause of death, and the cost associated with treatment will continue to increase. Aging is an inevitable part of life and unfortunately poses the largest risk factor for cardiovascular disease. Although numerous studies in the cardiovascular field have considered both young and aged humans, there are still many unanswered questions as to how the genetic pathways that regulate aging in model organisms influence cardiovascular aging. Likewise, in the molecular biology of aging | [
-0.0024771104,
-0.007984286,
0.016582256,
-0.025467891,
-0.017860765,
0.0023109044,
-0.0036309646,
0.010170536,
-0.037664864,
0.0142937265,
-0.015994143,
0.025020413,
-0.019318266,
0.01146183,
-0.0017227904,
0.016300986,
0.049606133,
-0.01334763,
0.03723017,
-0.0058939247,
-0.020456137,
0.03569596,
0.0051843524,
-0.011365942,
-0.013270919,
0.038713243,
0.013910173,
-0.027845917,
0.007907576,
-0.027845917,
0.0034967212,
0.0013272518,
-0.022386685,
-0.018142037,
0.0014878644,
0.009576029,
-0.0075240233,
-0.016275415,
0.005318596,
-0.030121664,
0.011934878,
-0.003979358,
-0.0035638427,
-0.010323958,
-0.0135394065,
0.012401533,
-0.019855238,
-0.045284774,
-0.014511073,
0.020686269,
0.01777127,
0.008559615,
-0.008457335,
-0.00558069,
0.015431599,
-0.01787355,
-0.010841753,
0.018154822,
0.011551325,
-0.023575699,
-0.00057293166,
-0.01571287,
-0.020852476,
0.005740504,
-0.025595743,
0.015316533,
-0.012951292,
0.035337977,
0.010886501,
0.027615786,
0.021734647,
0.019510042,
0.010777827,
0.043341443,
-0.00049981696,
-0.0020887635,
-0.027334515,
-0.0021862497,
-0.014498288,
0.012772301,
0.00090374576,
-0.028638594,
0.008930382,
0.023243288,
0.019164843,
-0.00636058,
-0.013590546,
0.0006947895,
0.0026880645,
-0.0101641435,
0.013385985,
-0.015316533,
0.0041263867,
0.03147688,
-0.0048583327,
-0.022616817,
0.00070238067,
0.0038898624,
0.0017227904,
-0.023422278,
-0.029252278,
-0.004874314,
0.0016908277,
-0.0063382066,
-0.032141708,
-0.00022813388,
-0.012791479,
-0.0025825873,
0.018947497,
0.00034060268,
0.00061807904,
0.04300903,
-0.00084061944,
0.001189013,
0.013807893,
-0.03216728,
0.015137542,
-0.00016420845,
0.010995174,
0.00016670553,
0.029328987,
0.0076326965,
0.033241224,
-0.008930382,
-0.007191611,
-0.00811853,
-0.024994843,
0.012439889,
0.007939539,
0.0022933248,
-0.014396007,
-0.0039250213,
-0.02222048,
0.013974099,
-0.032295126,
0.020724624,
-0.00930115,
0.0032218418,
-0.013143068,
-0.023946466,
-0.0025474285,
0.019369405,
-0.0357471,
-0.008054605,
-0.0110591,
0.03845754,
0.033062235,
0.016620612,
0.011621644,
0.004835959,
0.009179692,
0.0030540375,
0.035005566,
-0.027360084,
0.0029389716,
0.022859734,
-0.017080875,
0.013922959,
-0.007984286,
-0.0012361581,
0.017400503,
0.004110405,
0.011250876,
0.011084669,
0.0025202602,
0.0100299,
0.008661896,
-0.00023612456,
-0.00095888146,
-0.01623706,
-0.020430569,
0.04454324,
-0.018512804,
0.018231533,
0.021517301,
0.015776796,
-0.011308408,
0.009793376,
-0.04024745,
-0.030198373,
-0.017132016,
0.0017355755,
0.021849712,
0.023486203,
-0.004835959,
0.002590578,
0.03988947,
-0.00076550705,
0.01995752,
-0.021031467,
-0.021427805,
0.028050479,
0.010649977,
-0.008035427,
-0.6550055,
-0.0023045118,
-0.012503814,
-0.011103847,
0.013015218,
0.00970388,
0.012133047,
0.020724624,
-0.015188683,
0.028485171,
-0.019637892,
0.018666226,
0.0076710517,
-0.0053857174,
-0.013059965,
-0.022130985,
0.0069550867,
-0.014638924,
-0.0026417184,
0.01696581,
0.008022642,
0.021236029,
-0.0135394065,
0.009544067,
0.012695591,
0.01938219,
0.0083166985,
-0.036309645,
-0.005874747,
0.0162882,
0.028076049,
0.02646513,
-0.0101321805,
0.010547696,
0.042676616,
-0.014587783,
0.013449911,
0.018794077,
-0.006533179,
0.02596651,
-0.018666226,
0.0026081577,
0.0053409697,
-0.01080979,
-0.024790281,
0.0089751305,
0.020647915,
-0.01073308,
0.011180558,
0.00008614951,
0.004896688,
0.0052642594,
-0.006923124,
-0.024087103,
-0.0010395873,
-0.0030380562,
0.029584689,
-0.02828061,
0.00560626,
-0.00043948734,
-0.017106446,
0.016543902,
-0.008105745,
-0.0038419184,
-0.023192147,
0.019816883,
-0.021555655,
0.037562583,
-0.0007970702,
-0.009160514,
0.010470985,
0.010049078,
-0.0018794077,
-0.03584938,
0.04024745,
0.007376995,
0.004215882,
0.004295789,
-0.033215653,
0.0056222416,
0.009173299,
0.0009780591,
-0.020328287,
0.031221181,
0.010720295,
0.009166907,
-0.004426836,
0.0078180805,
-0.02149173,
0.01189013,
0.0044108545,
0.009186084,
-0.012350393,
-0.032141708,
0.011807027,
0.0011554522,
0.0021383057,
-0.010279209,
0.0042318637,
0.00042989853,
-0.00017319796,
0.0022501752,
-0.007376995,
0.020328287,
0.004695323,
0.0296614,
-0.024368374,
-0.0024051943,
0.05226543,
-0.037332453,
-0.0011970036,
-0.009141336,
-0.0031691033,
-0.004024106,
-0.007824473,
-0.011666391,
0.015086401,
-0.020468922,
0.014920196,
-0.01784798,
0.012024374,
0.00393461,
0.00081025483,
-0.03577267,
0.021517301,
0.0024451478,
-0.0045003504,
0.0022389882,
0.004695323,
-0.028868726,
0.02242504,
-0.007587949,
0.018461665,
-0.009064626,
0.017170371,
-0.0042766114,
0.007875613,
0.0010212087,
0.0013727986,
0.0148307,
-0.012727553,
-0.008885635,
0.011206128,
0.010336742,
-0.027948199,
-0.00048223746,
-0.0078052953,
-0.012849011,
-0.007485668,
-0.005663793,
-0.0033944403,
-0.018116467,
-0.008879242,
0.020251576,
-0.009639955,
0.0055135684,
0.008009857,
-0.017311007,
0.0004778426,
-0.010228069,
0.013360415,
0.010899286,
-0.03117004,
0.011596073,
-0.003519095,
-0.006012187,
-0.031221181,
0.005130016,
-0.009384253,
-0.016722893,
0.013807893,
-0.021926424,
0.004532313,
0.0031722996,
0.00026628937,
0.027641356,
-0.011327586,
0.012260898,
-0.025582958,
-0.013411555,
0.002779158,
-0.028843155,
-0.018436095,
-0.0047049117,
0.013194209,
0.009946797,
0.010010722,
-0.0027951396,
0.017157586,
0.024048747,
-0.002246979,
0.029252278,
-0.042139646,
0.00461222,
-0.0020408195,
-0.017643418,
-0.0119476635,
-0.006156019,
0.01490741,
0.027053243,
0.031042188,
-0.01573844,
0.024624076,
-0.009339506,
0.016275415,
-0.012535777,
-0.0035446652,
-0.005085268,
0.007178826,
0.0152270375,
0.009218047,
0.019241555,
-0.0043053776,
-0.024803067,
0.019292695,
0.024266094,
0.00016011322,
-0.01772013,
-0.00030264695,
0.006485235,
-0.006264692,
-0.01555945,
0.015840722,
-0.037306882,
0.008029034,
0.027513506,
0.003963377,
0.033087805,
-0.008233596,
-0.0101321805,
-0.016492762,
0.00013763945,
0.022373902,
0.021760216,
-0.003765208,
0.008917598,
-0.0074281353,
-0.021478945,
0.02521219,
0.016595041,
0.011020744,
-0.019689033,
0.029865962,
-0.0152270375,
-0.006923124,
0.015111972,
0.036769908,
0.022680743,
-0.0071596485,
-0.001518229,
-0.0014095558,
-0.003614983,
0.0067697032,
-0.02214377,
-0.023741905,
-0.019791313,
0.017311007,
-0.005826803,
0.023895327,
0.011378727,
0.037664864,
-0.005181156,
-0.0007567173,
-0.003199468,
0.0028670556,
-0.0012880975,
-0.024291664,
0.007498453,
0.0034423845,
0.0024563347,
-0.012510207,
0.007811688,
0.002175063,
-0.036488637,
0.006357384,
0.017605064,
0.011512971,
-0.0061496263,
-0.0036309646,
0.016889099,
-0.0039473954,
-0.019689033,
-0.0044204434,
0.031553593,
-0.0068016658,
-0.025557388,
0.024521796,
0.0020264362,
-0.012625272,
0.02822947,
-0.006980657,
0.010010722,
-0.004193508,
-0.023767475,
0.010260032,
0.010157751,
0.02508434,
-0.024214953,
0.0059770276,
-0.0101961065,
-0.0022357919,
-0.013974099,
0.014229801,
-0.011238091,
0.012586918,
0.01181342,
-0.011014352,
0.015891863,
0.018205963,
-0.002612952,
-0.0078052953,
-0.031860434,
-0.0021271186,
-0.008182455,
0.010240854,
0.02948241,
-0.0029165978,
-0.012305645,
0.007958716,
-0.009000701,
0.010969604,
-0.024777496,
-0.032653112,
-0.029328987,
0.06878376,
0.00035818218,
0.0036437495,
0.019420546,
0.0055231573,
0.011826205,
0.014025239,
-0.024854207,
0.02810162,
0.017464427,
0.0034327956,
-0.015380459,
0.028561883,
-0.0053409697,
0.025276115,
0.04180723,
0.008009857,
-0.013385985,
-0.015904646,
-0.016889099,
0.008853672,
-0.02599208,
0.034545302,
0.057072625,
0.032908812,
-0.004298985,
0.00031203602,
0.023179362,
-0.01073308,
0.009371468,
-0.0005605461,
0.033036664,
-0.0047113043,
0.035005566,
-0.019740174,
0.016569471,
0.008757784,
0.015073617,
0.042395346,
0.011615251,
0.031272322,
0.004842351,
-0.00854683,
-0.00035039126,
0.015329318,
-0.010496556,
0.006942302,
0.009850909,
0.012407926,
-0.01636491,
0.029073287,
-0.017426072,
-0.036718767,
-0.029380128,
0.024726357,
-0.016901884,
0.0035095061,
-0.008808925,
-0.026567409,
-0.007926754,
0.00023612456,
-0.01183899,
0.016467191,
-0.008099352,
0.022182124,
0.018794077,
-0.0054080915,
-0.00035238895,
-0.0107586505,
-0.004308574,
0.025621314,
-0.011084669,
0.0046441825,
0.000109272536,
-0.009250009,
-0.0048455475,
0.01925434,
-0.034954425,
0.009697488,
0.009333113,
0.00034859337,
0.010573266,
-0.028357321,
-0.023089865,
-0.0033592815,
-0.0059003173,
-0.010432631,
-0.030300654,
0.006980657,
0.031758156,
-0.0026113538,
-0.0136672575,
0.008073782,
-0.008617148,
-0.007178826,
0.0004167139,
0.018039757,
0.02815276,
-0.0075048455,
-0.008431764,
0.0062806737,
0.0015102383,
-0.011506578,
-0.031783726,
-0.007990679,
-0.034570873,
-0.0074281353,
-0.014229801,
-0.0009684703,
-0.025557388,
0.014434363,
-0.03109333,
0.016224274,
0.012075514,
0.016173134,
0.005603064,
0.028868726,
0.023294427,
0.02664412,
-0.01229286,
-0.011512971,
-0.0024067925,
0.024918133,
0.0062327296,
-0.0054304656,
0.010272817,
0.00612086,
-0.0058683543,
-0.042420916,
-0.0014503082,
0.010017115,
0.019701818,
0.0005110039,
-0.04316245,
-0.021555655,
-0.0042094896,
0.016901884,
-0.00741535,
-0.0024387552,
-0.008534045,
-0.012471852,
-0.0007858833,
-0.007134078,
-0.015329318,
0.07282385,
-0.036053944,
0.0136033315,
-0.008035427,
0.0028670556,
-0.0014391213,
-0.017630633,
-0.009000701,
-0.012190579,
0.0010196107,
-0.0148307,
-0.011954055,
-0.00054176804,
-0.015866293,
0.018269889,
0.020839691,
0.026439559,
-0.022437826,
-0.004145564,
0.015815152,
0.013731183,
-0.0014487101,
-0.017681774,
0.015725655,
-0.0072811064,
0.026183857,
0.0031531218,
0.02146616,
-0.0025170639,
-0.024419514,
0.019740174,
-0.009179692,
0.0046537714,
-0.040426444,
-0.032090567,
-0.05318596,
-0.0014934579,
-0.006852806,
-0.025698023,
0.01573844,
-0.036590915,
-0.012363179,
0.033675916,
-0.0032633932,
0.0019784921,
-0.0100299,
-0.006565142,
-0.0046793413,
0.020878045,
-0.0156873,
-0.005248278,
0.0020615952,
-0.020686269,
-0.009096589,
0.021530084,
0.00038614956,
-0.010528519,
0.011282839,
0.022207694,
-0.00919887,
-0.0034519732,
0.008802532,
-0.034340743,
-0.01842331,
0.002542634,
-0.024739143,
0.007568771,
-0.024688002,
-0.016748464,
-0.030454075,
-0.011123025,
-0.004899884,
-0.02156844,
0.022783024,
-0.019049779,
-0.011922093,
0.0037108713,
-0.00022753458,
0.0007107709,
-0.003963377,
0.040273022,
0.007875613,
-0.0013576164,
-0.01694024,
-0.0023220913,
0.028587453,
0.014523858,
0.030249514,
-0.010618014,
-0.015725655,
-0.011519362,
-0.0038802736,
0.025199404,
-0.033062235,
-0.035261266,
0.026183857,
-0.006673815,
0.0014798738,
0.020481708,
0.0021095392,
-0.01490741,
0.0083166985,
0.0017227904,
-0.015725655,
0.015073617,
-0.037383594,
0.015917432,
0.01862787,
-0.017668989,
0.012849011,
0.00706376,
-0.031732585,
-0.016889099,
-0.007875613,
0.022910874,
0.0042414526,
0.0064308983,
0.013168639,
-0.010873715,
0.012017981,
0.0028878313,
0.008399801,
0.019740174,
0.016556686,
-0.019522827,
0.03884109,
-0.017311007,
-0.014996906,
0.0209164,
-0.009755021,
-0.019484472,
0.024419514,
-0.016121993,
-0.032013856,
-0.015239823,
-0.03262754,
0.007229966,
0.016569471,
-0.010528519,
0.026260568,
-0.024035962,
-0.03311337,
-0.02073741,
-0.013130284,
0.015367674,
-0.012983255,
-0.0012521393,
-0.0046569677,
0.0022869322,
0.014191446,
0.004756052,
-0.008687466,
-0.007696622,
0.027002102,
-0.02229719,
0.022706313,
0.012676413,
0.0013855837,
-0.020622345,
0.022540107,
-0.03518456,
0.0027040457,
0.009991545,
0.009460964,
-0.04175609,
-0.017157586,
-0.0058459807,
0.01691467,
0.009313935,
0.00015431999,
0.016173134,
-0.0013232564,
-0.00080466137,
-0.010234461,
-0.01555945,
0.029354557,
-0.027104383,
0.0083486615,
0.014984121,
-0.025698023,
0.01782241,
-0.020929186,
0.008892028,
0.0011810224,
0.010969604,
-0.038968943,
-0.028382892,
0.021184888,
0.00088297,
-0.00590671,
-0.027334515,
-0.008029034,
-0.021236029,
0.018947497,
-0.004011321,
-0.011078278,
-0.004369303,
0.0076199113,
0.0015869489,
0.0004119195,
0.0039505917,
0.011154988,
0.0048679216,
-0.01789912,
-0.012650843,
-0.015648946,
-0.009716665,
0.009959582,
0.024879778,
0.01334763,
-0.016876314,
-0.00093890476,
-0.046716705,
-0.012120262,
0.013462696,
0.031349033,
-0.0119157005,
0.026567409,
-0.010125788,
0.03270425,
0.001401565,
0.013948529,
-0.008418979,
-0.00040013326,
0.0123184305,
0.006648245,
-0.0003773598,
0.005539139,
-0.0073642097,
-0.009607992,
0.0156873,
-0.01927991,
-0.012222542,
-0.0047720335,
0.010349527,
0.021504516,
-0.0070701526,
0.011174166,
-0.0055838865,
-0.01784798,
0.0021862497,
-0.022731883,
0.008578793,
-0.0002189446,
-0.025007628,
-0.01696581,
-0.022910874,
-0.0052898293,
-0.010081041,
0.0009405029,
-0.0043948735,
-0.028459601,
-0.0009484936,
-0.0079139685,
0.02156844,
0.0031531218,
0.0043053776,
0.034647584,
-0.000612086,
0.01610921,
0.0019928752,
-0.0007447313,
-0.006341403,
-0.031553593,
-0.002884635,
0.012708375,
-0.001952922,
-0.019855238,
0.0040336945,
-0.018794077,
-0.010272817,
-0.015853507,
-0.032371838,
-0.008840887,
0.024918133,
-0.0016380892,
0.012126654,
0.010144966,
0.0129448995,
-0.027615786,
-0.008355054,
-0.022757454,
0.010528519,
-0.008514867,
-0.011007959,
0.004848744,
0.005730915,
-0.014920196,
0.012778694,
0.0070126196,
-0.005449643,
0.021389449,
0.19402647,
-0.0267464,
0.0033976366,
0.009716665,
0.0023380728,
0.023972036,
0.0252889,
-0.014140305,
-0.0022278014,
0.01724708,
-0.006967872,
0.010515734,
-0.021376664,
-0.0006840021,
0.002555419,
-0.033190083,
-0.026043221,
0.0028302984,
0.013168639,
-0.011046315,
-0.001306476,
-0.0043021813,
-0.004602631,
-0.019152058,
0.025276115,
-0.011672784,
-0.011768672,
0.0006272683,
0.020647915,
-0.010451808,
-0.0014431166,
-0.020277146,
-0.0002752789,
0.010228069,
-0.015840722,
-0.020021444,
-0.0037140676,
-0.019855238,
0.017055305,
-0.014523858,
0.009371468,
0.017963046,
-0.004110405,
-0.003199468,
0.014434363,
0.027539076,
0.0044715838,
-0.025199404,
-0.027615786,
-0.0072427513,
-0.04451767,
0.0011978027,
-0.008840887,
0.016134778,
-0.0020232399,
0.013424341,
0.00804182,
0.00044068595,
-0.0009141337,
0.0059290836,
-0.000105576844,
-0.012599702,
-0.010720295,
0.009710273,
-0.009205262,
0.029456839,
-0.016607827,
0.009646348,
-0.0026337279,
-0.0177457,
-0.03096548,
-0.018308243,
-0.02289809,
0.015955787,
0.0010507742,
-0.009531282,
0.01875572,
0.027129954,
0.0055359425,
0.0072555365,
-0.015188683,
-0.004803996,
-0.03117004,
-0.0021143337,
-0.019113705,
-0.041704953,
0.0045866496,
0.02646513,
-0.021504516,
-0.025455106,
0.009013486,
0.00007511238,
-0.008987916,
-0.00082783436,
0.028561883,
0.008278343,
0.0046154163,
0.011506578,
0.011960448,
0.006012187,
-0.018193178,
0.05783973,
-0.00520353,
0.0058140177,
0.011423474,
0.0021702684,
-0.033343505,
0.021069823,
0.0042798077,
-0.027206663,
-0.0078052953,
-0.010119395,
0.0048455475,
-0.0264907,
-0.021197673,
0.015648946,
0.02141502,
-0.014268156,
0.018384954,
-0.027334515,
-0.020123726,
-0.028894294,
-0.013085536,
0.039173502,
0.020200437,
-0.023869757,
-0.0096016,
-0.016774032,
-0.020967541,
-0.04280447,
-0.0037364415,
-0.014114735,
-0.032295126,
-0.013360415,
0.011091062,
0.0049542207,
-0.0044076582,
-0.007587949,
-0.0043053776,
0.017259866,
-0.005801233,
-0.027666926,
0.023844186,
0.021172103,
0.017489998,
-0.009269187,
-0.00816967,
0.010490163,
-0.0061975704,
-0.0064564687,
-0.020315502,
-0.00303486,
0.012836226,
0.009218047,
0.019484472,
-0.019893594,
0.002059997,
-0.01571287,
-0.00038375234,
0.00054776104,
-0.032243986,
0.029201137,
0.029175567,
-0.020047015,
0.009422609,
-0.001047578,
-0.15904647,
0.021095391,
-0.0016380892,
-0.007664659,
0.016786817,
0.0023524559,
0.016543902,
-0.00005988015,
0.012439889,
0.007965108,
0.040809996,
-0.011442652,
-0.007095723,
-0.028894294,
0.027794776,
-0.00854683,
-0.011346764,
0.0529814,
0.019548398,
0.0032186455,
0.031579163,
-0.010368705,
0.0031818883,
-0.023396708,
-0.013807893,
-0.008227203,
0.0030220747,
0.006590712,
-0.019791313,
-0.016671753,
-0.04589846,
0.01035592,
0.03119561,
-0.012337608,
-0.038073987,
-0.010413453,
-0.010867324,
-0.042190783,
-0.004570668,
0.0040432834,
0.031579163,
0.036769908,
-0.002154287,
0.0074473126,
-0.016837958,
0.01839774,
-0.00786922,
-0.017426072,
0.0252889,
0.000051739647,
0.022987586,
0.0011554522,
0.006814451,
0.018704582,
0.017643418,
-0.0016300984,
-0.0040177135,
0.009697488,
-0.008527652,
-0.009844516,
-0.0252889,
0.006795273,
0.014383222,
0.019701818,
0.014063595,
-0.016722893,
-0.03216728,
-0.0017499587,
-0.021236029,
0.026183857,
0.0018090897,
0.00039973372,
0.006980657,
0.016147563,
0.036028374,
0.0036884975,
0.0065523568,
-0.0075176307,
-0.010771435,
0.0019689032,
-0.017668989,
-0.0018522394,
-0.019676248,
-0.013449911,
-0.025672453,
0.009780591,
0.022629602,
-0.010490163,
0.007722192,
-0.015866293,
0.0038067594,
-0.04321359,
-0.00092691876,
-0.012849011,
-0.003567039,
0.0013879809,
0.0048199776,
-0.015406029,
0.0077157994,
0.0053217923,
-0.003461562,
0.0043277517,
-0.0038067594,
-0.006235926,
0.03114447,
-0.0050884644,
-0.013021611,
-0.0027471953,
0.026107145,
-0.002766373,
0.00025070756,
0.01412752,
0.00057892466,
0.029149996,
-0.0101321805,
0.012535777,
-0.007907576,
-0.020456137,
-0.0016061264,
-0.018282672,
0.04482451,
0.0049382397,
0.0010507742,
0.04612859,
0.011666391,
-0.015418814,
-0.11629315,
0.016147563,
0.003982554,
0.019471686,
0.015239823,
0.011333979,
-0.0018298655,
0.02448344,
0.0077157994,
0.031553593,
-0.006466057,
-0.02378026,
-0.007357817,
-0.0019337443,
0.032959953,
-0.028792014,
-0.0019545201,
-0.013628902,
-0.03587495,
0.029022146,
-0.008239988,
-0.022169339,
0.004621809,
-0.024854207,
-0.02224605,
0.0054464466,
-0.02594094,
0.0058811395,
0.00093171315,
0.0061847856,
0.021888068,
0.007153256,
-0.013961314,
0.0036309646,
-0.0000447478,
-0.01943333,
0.025455106,
-0.030377366,
0.0352357,
-0.02073741,
0.027845917,
0.018205963,
0.018960282,
-0.00042909945,
0.017208725,
-0.011206128,
-0.019829668,
0.0030780095,
-0.018653441,
-0.0130727505,
-0.00018738142,
-0.022373902,
-0.026286136,
-0.0122864675,
0.0072363587,
-0.026950961,
0.009045448,
-0.0328321,
0.0014822709,
-0.0025857836,
-0.013143068,
-0.0032585987,
-0.022003133,
0.010176929,
0.017285436,
-0.03390605,
-0.027181093,
-0.02440673,
0.011071885,
-0.021670721,
0.004660164,
0.00036677215,
-0.019267125,
0.009307543,
-0.027436795,
0.02797377,
-0.014600568,
-0.000012741387,
0.0016069255,
-0.009646348,
-0.006117664,
-0.018666226,
0.016863529,
0.007172433,
0.008003464,
0.016454406,
-0.0010995175,
-0.019356621,
-0.0007814884,
-0.016774032,
0.0113851195,
0.036539778,
-0.0028334947,
-0.0002932579,
0.00012805063,
0.020699054,
0.0056989524,
-0.013552192,
0.0066546374,
0.02063513,
-0.011365942,
0.008757784,
-0.029354557,
0.023319997,
0.019420546,
0.010228069,
-0.00919887,
-0.014523858,
0.03272982,
-0.003378459,
0.023179362,
0.0067121703,
0.015431599,
0.008591578,
-0.0033976366,
0.007990679,
-0.018257104,
-0.009870087,
0.022834163,
0.03385491,
0.020430569,
0.016147563,
0.015431599,
0.028664162,
-0.0034455808,
0.016722893,
-0.0048199776,
0.010975997,
0.0029453642,
0.017311007,
-0.008137708,
0.0039282176,
0.03099105,
-0.03288324,
0.005296222,
-0.0014551026,
0.0048167813,
-0.020686269,
-0.0023732316,
0.009876479,
0.008246381,
0.042114075,
-0.010202499,
-0.025403967,
-0.015265393,
-0.026541838,
-0.0040912274,
-0.004187116,
-0.042472057,
0.015930217,
0.018231533,
-0.007172433,
0.02661855,
0.011666391,
-0.028434033,
-0.028715303,
-0.02294923,
0.0024691198,
0.020187652,
-0.011186951,
0.014562213,
-0.030454075,
0.028024908,
0.00038375234,
-0.012101084,
-0.008035427,
-0.0012984853,
-0.03861096,
-0.019701818,
0.020098155,
-0.0019177629,
-0.01930548,
-0.0038003668,
0.019970305,
0.0053697363,
0.012196972,
0.0016197106,
0.0105988365,
-0.012708375,
0.017477212,
-0.013552192,
0.008176062,
0.013040788,
0.0141658755,
-0.025199404,
0.019995876,
0.003084402,
0.0221182,
-0.0027455972,
0.022041488,
0.005654204,
-0.0075751636,
-0.0209164,
0.016991379,
-0.008393409,
0.014217016,
0.013628902,
0.022003133,
-0.0108545385,
-0.0057373075,
-0.0016444817,
0.012797872,
-0.012548562,
-0.0014630933,
-0.027257804,
-0.016467191,
-0.0026545036,
0.0016492761,
0.0019257537,
-0.026234997,
-0.027360084,
0.011634428,
0.03119561,
0.03825298,
0.0029581494,
0.0072555365,
-0.0056094564,
0.005075679,
-0.01488184,
0.009793376,
-0.0057564853,
0.033599205,
0.0018474449,
0.0133732,
-0.0050341277,
0.0100043295,
0.011557718,
0.031272322,
0.0047113043,
0.0038419184,
0.01998309,
0.0020472119,
0.022872519,
-0.0067505254,
-0.016006928,
0.0012497422,
0.009908441,
-0.043443725,
0.0064085242,
0.0036469458,
-0.007006227,
0.053032536,
0.003058832,
-0.007108508,
0.009582422,
-0.0019800903,
0.0156873,
0.0029389716,
0.018921928,
-0.038099557,
-0.01875572,
-0.005874747,
-0.0357471,
-0.0041999007,
-0.028971005,
-0.008981523,
0.022731883,
-0.0019225574,
0.013884604,
0.01475399,
-0.021632366,
0.0042670225,
-0.016543902,
0.014472717,
0.011148595,
-0.016607827,
-0.02229719,
0.039608195,
-0.005424073,
-0.0061975704,
-0.0014263361,
-0.01261888,
0.014089165,
-0.012861797,
0.008003464,
0.0062391222,
0.011525755,
-0.010918464,
-0.036642056,
-0.018218748,
-0.019036993,
-0.019727388,
0.01995752,
-0.020021444,
-0.027027672,
-0.028613023,
-0.0028159153,
-0.009761414,
-0.016620612,
-0.015891863
] |
Proper execution of transcriptional programs is a key requirement of gene expression regulation, demanding accurate control of timing and amplitude. How precisely the transcription machinery fulfills this task is not known. Using an in situ hybridization approach that detects single mRNA molecules, we measured mRNA abundance and transcriptional activity within single Saccharomyces cerevisiae cells. We found that expression levels for particular genes are higher than initially reported and can vary substantially among cells. However, variability for most constitutively expressed genes is unexpectedly small. Combining single-transcript measurements with computational modeling indicates that low expression variation is achieved by transcribing genes using single transcription-initiation | [
-0.028027266,
-0.022128873,
0.0063701333,
-0.020571804,
-0.018803604,
0.017154165,
-0.005007697,
0.014158784,
-0.021851767,
-0.01328788,
0.019740485,
0.016547171,
-0.00014040849,
0.01855289,
-0.008484714,
0.0003154552,
0.03739608,
-0.005103364,
-0.011077632,
0.006413019,
-0.022735866,
0.014897733,
-0.010048382,
-0.0045557506,
-0.02643061,
0.040404655,
0.015254011,
-0.02837035,
-0.010444247,
-0.017866723,
0.008352759,
0.0037046399,
-0.011427313,
-0.010299097,
-0.018249393,
-0.020664172,
0.007844732,
-0.026417414,
0.013525399,
-0.0009146139,
0.026391024,
0.018948754,
-0.01037827,
0.012331205,
-0.010721353,
0.004839454,
0.005403562,
-0.012911808,
0.002093138,
0.022511544,
0.009474377,
0.017616007,
-0.033147126,
0.00993622,
-0.02887178,
-0.0041005053,
0.00299868,
0.023567185,
-0.017721573,
0.003510006,
-0.020743344,
-0.005650978,
-0.027684184,
0.035020888,
-0.004945018,
0.0071783583,
0.0034935118,
-0.00036102094,
0.006139212,
-0.020466238,
0.01584781,
0.014805364,
-0.005053881,
0.030771933,
0.0252826,
-0.03066637,
-0.0088212,
0.012925004,
0.0019149986,
-0.0003237024,
0.0019776772,
-0.011493291,
0.006089729,
0.025322188,
-0.0027001316,
0.016309652,
0.012713876,
0.02451726,
0.006653837,
-0.009487573,
0.03256652,
0.032592915,
0.024398502,
0.022841431,
-0.006888057,
-0.002149219,
0.014343522,
0.027156362,
0.009184076,
-0.010490431,
-0.013974047,
0.004394105,
-0.0058753015,
-0.013010775,
-0.01819661,
0.0046052337,
0.015451944,
-0.014950515,
0.01776116,
-0.035390362,
-0.007508246,
0.030217722,
-0.017193751,
-0.02466241,
0.036947433,
0.015874201,
0.020888494,
-0.007382889,
-0.01334726,
0.0045029684,
0.024055418,
0.017774355,
0.0063272477,
-0.024504066,
0.024292937,
0.027393883,
-0.0132285,
0.012027709,
-0.014422694,
-0.015478335,
0.0053837686,
0.0019034526,
0.0258764,
0.039665706,
-0.03016494,
-0.026918843,
-0.015003297,
-0.0043908064,
0.0012659444,
-0.048823394,
-0.004677809,
0.022340002,
-0.023026168,
0.011974927,
-0.0047437865,
0.012021111,
0.030534415,
0.019318229,
0.00086265657,
0.010635583,
0.01922586,
-0.004753683,
0.008808004,
-0.010840113,
0.017893113,
0.00050843955,
-0.0016593356,
0.022208046,
-0.0043380246,
-0.009883438,
0.009494171,
0.010490431,
0.01243677,
0.008854188,
-0.017206946,
0.031827573,
0.005776335,
-0.007171761,
-0.003783813,
-0.0063437424,
-0.020690562,
-0.00064781716,
-0.047556624,
0.029320426,
-0.0031768195,
-0.0043413234,
-0.0012692433,
0.012931601,
-0.02319771,
-0.016877059,
0.008339563,
0.005162744,
0.015214425,
0.017708376,
-0.006894655,
0.006244776,
-0.004578843,
0.009098305,
0.019885637,
-0.009975807,
-0.02487354,
0.0085243005,
0.0040939073,
0.0003810204,
-0.6435187,
-0.01714097,
0.015069274,
-0.041460298,
-0.012001318,
0.025625683,
0.004677809,
-0.020466238,
0.00614581,
0.05077633,
-0.014317131,
0.022603912,
0.015003297,
-0.028687043,
-0.019001536,
-0.02336925,
0.0054464475,
-0.029003736,
0.025414556,
0.008887177,
-0.03713217,
0.0062315804,
-0.004991202,
0.022735866,
0.012324608,
0.007778754,
0.027367491,
-0.017180556,
-0.0069408393,
0.03895315,
-0.026272263,
0.02552012,
-0.010734549,
0.00149934,
0.0482164,
0.009236858,
0.0005900868,
0.019938419,
0.01584781,
0.03686826,
-0.009942818,
-0.015623486,
0.01678469,
0.017048601,
-0.02458324,
0.011928743,
0.0027974485,
0.0051957327,
0.012944797,
-0.037791945,
-0.012601714,
0.012430172,
-0.01296459,
-0.002604464,
0.009401802,
0.007132174,
0.024464479,
-0.01596657,
0.013076752,
-0.01258192,
-0.00022659168,
0.0054167574,
-0.015768636,
0.0057631396,
-0.017827136,
-0.014409499,
0.014013633,
-0.0033335162,
-0.0019116998,
0.0258764,
0.012806244,
0.0106883645,
0.001140587,
0.011156805,
-0.0017517041,
0.036182094,
0.00027999227,
-0.010299097,
0.020835713,
0.0101539465,
0.00047916203,
-0.018236198,
-0.035891794,
-0.021878159,
0.019397402,
-0.004730591,
-0.029162081,
0.022405978,
0.00014164558,
-0.0072047496,
0.006459203,
0.022445565,
0.00090224313,
-0.05420716,
-0.03916428,
0.016692322,
-0.00084533746,
0.013241696,
0.025467338,
-0.023778312,
-0.011816581,
-0.01443589,
0.011374531,
0.004948317,
0.0044798763,
0.007574224,
-0.017866723,
-0.0043644155,
0.022854626,
-0.021838572,
0.0070661963,
-0.017866723,
-0.01908071,
-0.020584999,
-0.024055418,
-0.026417414,
0.027011212,
0.012680886,
-0.009810863,
-0.023303274,
-0.008603473,
-0.009830656,
0.014383107,
-0.012040905,
-0.0044468874,
-0.006921046,
0.010061578,
-0.023949854,
0.009916427,
0.010140751,
0.015781833,
-0.018420935,
0.019120296,
-0.032144267,
0.0022531336,
-0.0062084883,
0.010899493,
0.021231579,
0.015016492,
-0.016336044,
-0.0128524285,
0.0050175935,
0.01692984,
0.0020238615,
-0.004328128,
-0.01637563,
-0.030481633,
-0.00596767,
0.013149328,
0.0019215964,
0.0070925876,
0.004912029,
0.000040437026,
0.016388826,
-0.011341542,
-0.011064436,
-0.036261268,
-0.023778312,
0.010879699,
-0.01102485,
-0.011598855,
0.023765117,
-0.013037166,
-0.0010572904,
-0.026998017,
-0.0052914,
-0.01334726,
-0.005617989,
-0.021535074,
-0.02245876,
0.0134990085,
-0.009507366,
0.005872003,
0.004288541,
0.016969427,
-0.004572245,
-0.026232677,
0.009362215,
-0.0066076526,
-0.0232241,
-0.0014754231,
-0.010384868,
-0.017035406,
-0.019463379,
0.036973823,
0.020294696,
0.012390586,
-0.005604794,
0.027657792,
0.023897072,
0.005152847,
-0.006317351,
-0.024741584,
0.03119419,
0.0029393001,
-0.01611172,
0.0056080925,
-0.006535077,
-0.006053441,
0.028528696,
0.025506925,
-0.00082142063,
0.0010787331,
-0.018183416,
0.014330326,
-0.021970527,
-0.0019595334,
-0.016164502,
-0.0037475254,
0.0051000654,
0.011071035,
0.0032361993,
0.0042522536,
-0.012865623,
0.01828898,
0.0064691,
-0.0020898392,
-0.00039215412,
-0.0009385308,
0.012199251,
0.0034539253,
0.0056641735,
0.023527598,
-0.009375411,
-0.008900372,
0.020967668,
-0.00084946107,
0.020611389,
-0.00282219,
0.01637563,
-0.015676267,
0.014752582,
-0.0058027264,
0.00004484412,
0.02075654,
0.007132174,
0.014185175,
-0.020809323,
0.03040246,
0.024992298,
0.0010655376,
0.012957993,
-0.0051957327,
-0.01443589,
0.009513964,
0.006548273,
0.035179235,
0.019252252,
-0.002878271,
-0.0060468432,
0.008069055,
0.014079611,
-0.017470857,
-0.0060864296,
0.0053672744,
-0.004107103,
0.007105783,
0.0022531336,
0.019305034,
0.016507585,
-0.00582252,
0.0031652735,
0.0083263675,
-0.037290517,
-0.019331425,
0.015861005,
0.018368153,
-0.024860345,
-0.024926322,
0.015042883,
-0.013393444,
-0.0012304814,
-0.002754563,
-0.012898613,
0.021878159,
-0.01755003,
-0.005103364,
0.028449522,
0.027736966,
0.0037244332,
-0.00015906777,
-0.021627443,
0.020109959,
0.02425335,
-0.021733008,
-0.021904549,
-0.01725973,
-0.013564986,
-0.011895753,
0.0025417854,
0.0062579713,
0.00087420264,
-0.0009904881,
-0.0027925002,
0.01328788,
0.0146998,
0.03385968,
-0.005265009,
0.005532218,
-0.0028716733,
0.0031735206,
-0.0064691,
-0.0015381018,
-0.02387068,
0.04916648,
0.0087486245,
-0.013960851,
-0.011856168,
0.0111238165,
-0.017695181,
0.004328128,
0.010675169,
0.000014200638,
-0.018473716,
-0.009447986,
0.01378931,
-0.01314273,
0.009131294,
0.027182754,
0.005274906,
-0.007976687,
-0.040114354,
0.01855289,
0.020215524,
0.020505825,
0.009151087,
-0.012179458,
0.0099296225,
-0.008557289,
-0.008431932,
-0.009659114,
-0.02707719,
0.025427751,
-0.025981963,
-0.011618648,
0.0035265004,
0.014449085,
-0.014739387,
0.0045293593,
0.0059049916,
-0.0027529136,
-0.042199247,
-0.0051231575,
0.023012972,
0.020255111,
0.012324608,
0.016058939,
0.027552228,
0.029346818,
-0.01102485,
0.0038860783,
0.0147921685,
0.014871342,
-0.0032263026,
-0.013564986,
0.04074774,
0.019859245,
0.0017714974,
-0.0015339783,
-0.009045524,
0.021271165,
0.0045095664,
-0.014778974,
0.005492632,
0.030032985,
0.034941714,
0.022841431,
0.0020337582,
-0.006007257,
-0.024279742,
-0.011796787,
0.014712996,
-0.0070727943,
-0.01984605,
0.01937101,
-0.026773693,
-0.00993622,
-0.023448424,
0.008867384,
-0.0106883645,
0.011526279,
0.0050208922,
-0.005749944,
-0.014541454,
-0.010127556,
-0.013657355,
0.027182754,
-0.01419837,
-0.018764017,
0.004829557,
-0.00025958047,
-0.009949416,
-0.01692984,
0.0051264563,
-0.009454584,
-0.028687043,
-0.03945458,
0.0040906086,
0.0423312,
0.020400262,
0.0052584116,
-0.012839233,
-0.005891796,
0.006030349,
-0.026562566,
-0.02516384,
-0.012931601,
-0.025388164,
-0.0056839664,
-0.019450184,
0.012001318,
-0.016573563,
-0.0078777205,
-0.009454584,
0.012100284,
-0.007389487,
0.028185613,
-0.0027809541,
-0.009520561,
0.024781171,
0.016006155,
0.013657355,
0.019898832,
-0.016309652,
0.0044534854,
-0.020083569,
-0.024266547,
-0.03515284,
-0.016085329,
-0.031484492,
-0.00052081037,
0.0021459202,
0.0060699354,
-0.0077193743,
0.008669451,
-0.020030787,
0.013749723,
0.021983722,
0.041169997,
0.026457,
-0.004601935,
0.018341761,
0.001302232,
0.0064954907,
-0.0016667581,
-0.0019116998,
0.036973823,
-0.005377171,
-0.022630302,
0.0090719145,
-0.016019352,
-0.035759836,
-0.025322188,
0.0030795026,
0.003092698,
0.054312725,
0.010747745,
-0.01855289,
-0.014462281,
-0.019648116,
-0.00037854625,
0.026391024,
0.0045854403,
-0.011499888,
-0.0093952045,
0.010939079,
-0.008860786,
0.0005740048,
0.0031553768,
-0.041829772,
-0.002202001,
0.01819661,
0.020743344,
0.017893113,
0.019146688,
0.009553551,
-0.019819658,
-0.016045742,
0.0015504726,
-0.036921043,
0.005984165,
0.0049615125,
0.048876174,
0.005891796,
0.0208753,
0.011235978,
-0.0208753,
0.01114361,
0.0019298436,
0.00089976896,
-0.00073523744,
0.005482735,
0.0042522536,
0.013815701,
0.011433911,
0.0044798763,
0.029320426,
-0.014409499,
0.01570266,
0.028950952,
-0.020980863,
-0.01611172,
-0.013129534,
-0.010952274,
-0.028977344,
0.014264348,
-0.0060138544,
-0.0062843626,
-0.018671649,
-0.006089729,
0.016890256,
-0.0006647239,
0.016336044,
0.0015075873,
0.026298655,
-0.011176598,
0.023817899,
-0.005324389,
0.0037112376,
-0.023395643,
-0.022907408,
-0.0105762025,
-0.007033208,
0.02578403,
0.0047998675,
0.014633822,
-0.0146998,
-0.010404661,
-0.014739387,
0.01740488,
-0.026747303,
-0.015570704,
-0.006914448,
-0.01702221,
-0.031220581,
-0.023408838,
-0.014488672,
-0.024187373,
-0.0020073673,
0.008794809,
-0.0012585219,
0.012562127,
-0.0074422685,
-0.0044106,
0.029927421,
0.00993622,
0.03016494,
-0.01919947,
0.022762258,
0.018869583,
-0.0034341319,
-0.027182754,
-0.039058715,
-0.0029970305,
-0.0009871892,
0.02889817,
0.013116338,
-0.010503627,
0.0019958213,
0.02654937,
-0.0012098635,
0.0014028478,
-0.01702221,
0.006568066,
-0.00985045,
-0.031009452,
-0.0064987894,
-0.004377611,
-0.015399162,
0.012634702,
-0.005189135,
0.016560366,
0.0011133713,
0.008979546,
-0.009091708,
0.0063866274,
0.016045742,
0.007508246,
0.0007067846,
-0.0044534854,
-0.020321088,
0.0028287878,
-0.022881018,
0.003889377,
-0.018368153,
0.022405978,
0.0030976464,
0.01611172,
-0.010200131,
0.015623486,
-0.0077193743,
-0.014620627,
-0.024266547,
0.03686826,
-0.023751922,
-0.0022861224,
0.017299315,
0.017444467,
0.0060666366,
0.014765778,
-0.0024081809,
-0.012245435,
-0.015808223,
-0.0039025727,
0.027129972,
0.010127556,
0.018064655,
-0.0114471065,
0.0066010547,
-0.020268306,
-0.0030646576,
-0.0241082,
0.007053001,
-0.028977344,
0.006083131,
0.014475476,
0.03098306,
0.039850444,
-0.007105783,
0.001670057,
-0.010160544,
0.031035844,
-0.015372771,
0.029241255,
0.015742246,
-0.018170219,
-0.015834615,
0.015385967,
-0.01857928,
-0.03140532,
0.015214425,
-0.02181218,
-0.0082010105,
0.00934902,
-0.003269188,
0.025889594,
0.0145810405,
-0.024464479,
-0.0064328117,
0.0045029684,
0.007923905,
-0.009870242,
0.00317517,
-0.017035406,
-0.01819661,
0.0005476137,
0.017193751,
-0.0023125135,
0.0048592472,
0.0049318224,
-0.014000438,
0.023699138,
-0.005872003,
-0.014924124,
-0.016058939,
0.010490431,
-0.016837472,
0.018988341,
0.014647018,
-0.018869583,
-0.008814602,
0.02281504,
0.002690235,
-0.0022382888,
-0.040800523,
0.0013088299,
-0.0065020886,
0.012628105,
-0.016797887,
0.007910709,
-0.0048262584,
-0.032355394,
-0.039929617,
0.008484714,
-0.016177697,
0.030085767,
0.026562566,
-0.0071915537,
-0.03224983,
0.0015677917,
-0.044204965,
-0.03385968,
0.027974484,
0.011697821,
-0.0037112376,
0.017536836,
-0.007435671,
0.005532218,
-0.010305694,
0.027156362,
-0.010160544,
-0.018684845,
0.0040741144,
0.0011711017,
-0.0012057399,
0.0002088602,
-0.02336925,
-0.013188914,
0.03454585,
-0.0071585653,
-0.014528259,
0.03267209,
-0.008036067,
0.043228496,
-0.014449085,
-0.010780733,
-0.0031586755,
0.02084891,
0.03269848,
-0.03198592,
-0.013505606,
0.016797887,
-0.009190674,
-0.013505606,
0.007785352,
-0.019964809,
-0.0026539473,
0.009711897,
-0.009751483,
-0.026417414,
-0.0019446885,
-0.016586758,
0.012786451,
0.02228722,
-0.0033120734,
0.012595116,
0.0024164282,
-0.014871342,
-0.011849569,
-0.00094595324,
-0.00009654372,
-0.0031850666,
-0.015122056,
0.0033186711,
-0.02336925,
0.0061227176,
-0.009210467,
0.007620408,
-0.0064394097,
0.0023273584,
-0.019278642,
-0.01857928,
-0.0296899,
-0.022181654,
-0.024701998,
-0.01173081,
-0.003787112,
-0.010925883,
-0.015016492,
0.01390807,
-0.017681986,
-0.007382889,
0.026562566,
-0.0027215744,
0.0077655585,
-0.0031949633,
-0.017800745,
0.024675608,
-0.015174839,
0.0066010547,
0.19191553,
-0.015254011,
-0.010200131,
0.008412139,
-0.006455904,
-0.036498785,
0.015623486,
0.0018605671,
0.0017220143,
0.010985264,
0.0042357594,
-0.0010548162,
-0.006515284,
-0.007785352,
0.014897733,
-0.020809323,
-0.023659553,
-0.005756542,
-0.030877497,
0.008135033,
0.0057631396,
-0.025625683,
-0.0022646796,
-0.016599953,
0.043993834,
-0.0038959747,
-0.007950296,
0.012674289,
0.016402021,
0.02228722,
-0.026219482,
0.015926983,
0.005486034,
-0.013070154,
0.02164064,
0.017998679,
-0.006736309,
0.008610072,
-0.008088849,
-0.03897954,
-0.012898613,
0.011242576,
-0.0073499,
-0.020439848,
0.028264785,
-0.014343522,
-0.008808004,
-0.017352099,
-0.012694082,
0.0011587308,
-0.034070812,
0.020334283,
-0.006921046,
0.034334723,
-0.001755003,
-0.012832635,
0.010147348,
0.015742246,
0.010714755,
0.031801183,
-0.016428413,
-0.008062458,
-0.014488672,
-0.0032675385,
-0.023131732,
0.026417414,
-0.0049219257,
0.016217284,
0.0075478326,
-0.010371672,
0.012001318,
0.004588739,
-0.010417856,
0.0047437865,
-0.005670771,
0.008029469,
0.048401136,
0.02319771,
0.025216622,
0.0077655585,
0.019885637,
-0.0053639757,
-0.038768414,
0.0058818995,
0.009382009,
-0.036208484,
0.018790409,
-0.017233338,
-0.008926764,
-0.022590715,
0.012034306,
-0.0048262584,
-0.007956893,
-0.010391465,
-0.014990102,
0.0018523199,
-0.014422694,
0.0066373423,
-0.0154387485,
-0.018961951,
-0.032909606,
0.055737842,
0.009500768,
0.021864964,
-0.0044138986,
0.007824939,
-0.008266988,
-0.008306575,
-0.013591377,
-0.004166483,
0.016824277,
-0.016547171,
0.01893556,
-0.01334726,
0.008742026,
0.015808223,
0.018777214,
-0.054022424,
0.054022424,
-0.004189575,
-0.010048382,
-0.018328566,
-0.009461182,
0.022524739,
-0.01520123,
-0.0076336036,
-0.022537934,
0.024411697,
-0.02887178,
-0.03639322,
0.01211348,
0.011744006,
0.01017374,
0.006574664,
0.018605672,
-0.033701338,
-0.010873102,
-0.002375192,
-0.037765555,
0.0036287657,
-0.019476576,
-0.01934462,
0.011394325,
0.03251374,
-0.0026539473,
-0.015940178,
0.023672748,
0.01743127,
-0.009177478,
-0.005443149,
0.0013393444,
-0.00036019622,
-0.00878821,
-0.015597095,
0.015610291,
-0.0009187375,
-0.0043644155,
-0.04486474,
-0.02554651,
0.020281501,
-0.04768858,
0.014752582,
0.017681986,
-0.008339563,
-0.0066934233,
-0.0004210193,
-0.16563006,
-0.0024906527,
0.013683746,
-0.038082246,
0.020162743,
0.020809323,
0.01661315,
0.014211566,
-0.002272927,
0.009639321,
0.020426651,
-0.010101164,
-0.03127336,
-0.027420273,
0.0036056736,
0.0007649273,
-0.008253792,
0.024530455,
0.016402021,
0.0048658447,
0.013881679,
-0.02063778,
0.008583681,
-0.02566527,
-0.010325488,
0.002378491,
0.0033698038,
-0.018447325,
-0.011875961,
-0.019093905,
-0.013446227,
0.029980203,
0.002640752,
-0.025335383,
0.0052881013,
0.002202001,
-0.010272706,
-0.0047668787,
-0.013696942,
0.010239718,
0.014383107,
0.019410597,
-0.023012972,
0.010734549,
-0.0010292499,
0.037475254,
0.007059599,
-0.0096063325,
0.0015150097,
-0.0057466454,
0.00896635,
-0.007382889,
-0.0067890906,
0.02695843,
0.034123592,
0.001660985,
0.0074488665,
0.02530899,
-0.0052386182,
-0.0034506263,
0.004595337,
-0.025863202,
0.04151308,
0.01179019,
-0.011480095,
-0.020426651,
-0.014594236,
0.007752363,
-0.03689465,
-0.0050406856,
-0.020743344,
-0.0008486363,
0.0055190227,
-0.02837035,
0.011440509,
0.004592038,
0.007053001,
0.010556409,
-0.012944797,
-0.00817462,
-0.010384868,
0.019859245,
-0.026087526,
-0.03042885,
-0.008187815,
-0.0011900702,
0.032381784,
0.023474816,
-0.019898832,
0.0043017366,
0.019740485,
0.013696942,
-0.0013220253,
-0.015465139,
0.014594236,
-0.0023768416,
0.013334065,
0.002002419,
-0.00017277873,
-0.003618869,
0.02102045,
-0.019608531,
-0.02472839,
0.013749723,
0.049219258,
-0.009797667,
-0.01972729,
-0.0064394097,
0.03657796,
0.008511105,
-0.020479435,
0.0015001647,
0.006195293,
0.04518143,
-0.003539696,
0.039085105,
-0.0045755436,
-0.0031421813,
-0.00629096,
-0.015280402,
0.06529139,
0.0017104682,
-0.020888494,
0.016217284,
0.0085243005,
-0.03298878,
-0.13248293,
-0.0137101365,
-0.010417856,
0.0028584776,
0.00635034,
0.022419175,
-0.0016255222,
0.0399824,
-0.014673409,
0.018170219,
-0.029267645,
-0.01857928,
-0.0046547167,
-0.015610291,
-0.0029442485,
0.0052551124,
0.010332086,
0.0132285,
-0.005053881,
0.01908071,
-0.0060864296,
0.002931053,
-0.016718714,
-0.010160544,
0.008266988,
0.00846492,
-0.042146463,
0.009375411,
0.017338902,
0.0031652735,
-0.0022234437,
-0.014330326,
0.01367055,
0.0022663292,
-0.0040411255,
-0.014752582,
-0.013195512,
-0.018249393,
0.021126015,
0.004888937,
-0.0017137671,
0.015412358,
0.010787331,
0.008867384,
0.0065878592,
0.0088212,
0.004103804,
0.011922145,
-0.017378489,
-0.019912027,
-0.028660651,
-0.025718052,
-0.019027928,
-0.026918843,
0.012186055,
-0.0025780732,
0.019423794,
-0.0010045083,
-0.024886735,
-0.009309433,
0.019265447,
0.0059313825,
-0.0110116545,
0.013221903,
0.005548713,
-0.025243014,
-0.022274023,
-0.041908946,
0.024332523,
-0.025889594,
-0.0114603015,
0.017365294,
-0.017813941,
-0.01346602,
-0.030270504,
0.014950515,
-0.02760501,
-0.029557947,
0.003025071,
0.00072039245,
0.000614416,
-0.030376067,
0.036314048,
-0.03457224,
0.014633822,
0.01270068,
0.0017731469,
-0.008722234,
0.008405541,
-0.0049813055,
-0.005677369,
0.030930279,
-0.005647679,
-0.008900372,
-0.02913569,
0.0097184945,
-0.020967668,
-0.004004838,
0.0070727943,
0.007561028,
-0.016507585,
-0.012219043,
-0.04098526,
-0.003231251,
-0.0029904328,
-0.015056079,
0.015887396,
-0.018790409,
-0.0046712114,
0.01613811,
-0.015359576,
0.0056608743,
-0.026298655,
-0.014528259,
-0.016718714,
-0.013617768,
-0.035495926,
-0.0073433025,
0.039375406,
-0.017985482,
0.018777214,
0.036947433,
0.0027083787,
-0.0018275784,
-0.0036452601,
0.020505825,
-0.017035406,
-0.001202441,
-0.010787331,
0.025045082,
-0.015385967,
-0.016705519,
0.00573345,
-0.010985264,
0.00057730364,
0.005951176,
-0.01905432,
-0.009533757,
0.025599293,
0.03715856,
0.033754118,
0.01828898,
-0.02257752,
-0.017352099,
0.009236858,
0.013294478,
0.0049648113,
0.035918184,
-0.027288318,
0.011974927,
-0.0014952164,
-0.006564767,
0.01984605,
0.011202989,
0.009520561,
-0.02164064,
-0.011776994,
0.00038060805,
-0.007376291,
-0.00661425,
0.006244776,
-0.02272267,
0.03510006,
0.0075016483,
0.0101539465,
-0.0105762025,
0.008365954,
0.011031448,
-0.013215305,
0.0005142126,
0.0013855287,
-0.022920603,
-0.029452382,
0.0075016483,
0.013591377,
-0.010068175,
-0.00043091594,
0.0008964701,
-0.016151307,
0.019634921,
-0.008610072,
0.01419837,
0.015385967,
0.010325488,
0.0069804257,
0.02425335,
0.04045744,
0.017589618,
0.0073367045,
0.025995158,
-0.008669451,
-0.008656256,
-0.0055685057,
0.024358915,
-0.00033339285,
0.010655376,
0.020571804,
0.031827573,
-0.012133273,
0.018143829,
0.00046967773,
0.022326807,
0.008669451,
0.021469098,
0.0048988336,
-0.033727728,
-0.010774136,
0.020954473,
-0.034756977,
-0.014422694,
-0.027050799,
-0.004578843,
-0.011400922,
0.0104772365,
0.01122938,
-0.009170881,
-0.009876841,
-0.001931493,
-0.008834395,
-0.013947655,
-0.027684184,
0.036340438,
0.014633822,
0.00767319,
0.012285021,
-0.018354956,
0.029478773,
0.011255772,
0.015333185,
-0.026826475,
0.011282163,
-0.016124915,
0.03356938,
0.020967668,
-0.007884318,
-0.015808223,
0.0045359572,
-0.017154165,
0.004031229,
0.015755441,
-0.012390586,
0.07194193,
0.008029469,
-0.0024560145,
0.0065449737,
-0.017206946,
0.040114354,
0.0100549795,
0.019648116,
-0.008590278,
-0.043809097,
0.02695843,
-0.014396303,
0.02781614,
-0.049113695,
0.0007055475,
0.037580818,
-0.0073103136,
0.021957332,
-0.032856826,
-0.007706179,
0.008946557,
-0.021244774,
-0.010028589,
-0.005868704,
-0.029637119,
-0.009197271,
0.041671425,
0.018209806,
-0.0025170438,
-0.024477674,
0.01908071,
-0.02193094,
-0.024121396,
-0.012832635,
0.0024675606,
-0.0064328117,
-0.0029623923,
-0.011064436,
0.012733669,
0.016415216,
0.012885417,
-0.015821418,
-0.013604573,
-0.029056517,
-0.017523639,
0.008504507,
-0.018711235,
-0.009019133,
0.0014440838
] |
In mammalian mitochondria, 22 species of tRNAs encoded in mitochondrial DNA play crucial roles in the translation of 13 essential subunits of the respiratory chain complexes involved in oxidative phosphorylation. Following transcription, mitochondrial tRNAs are modified by nuclear-encoded tRNA-modifying enzymes. These modifications are required for the proper functioning of mitochondrial tRNAs (mt tRNAs), and the absence of these modifications can cause pathological consequences. To date, however, the information available about these modifications has been incomplete. To address this issue, we isolated all 22 species of mt tRNAs from bovine liver and comprehensively determined the | [
-0.015029708,
-0.036559466,
-0.017245032,
-0.03337577,
-0.014326641,
0.0161838,
-0.033534955,
0.013888883,
-0.015732775,
0.013742964,
-0.00071591756,
0.008105164,
0.018571572,
-0.020030767,
-0.008635781,
-0.0045235045,
0.013583778,
-0.011023555,
0.0016158926,
-0.0064071924,
-0.02609306,
0.0064702034,
-0.013676637,
-0.020534853,
0.028679814,
0.02793695,
0.028149197,
-0.029077776,
-0.030616565,
-0.03669212,
-0.010672022,
-0.0043510543,
-0.012927141,
-0.028414506,
-0.011865908,
-0.015507263,
0.0012585557,
-0.0023114975,
0.008801599,
-0.006194946,
0.021569556,
0.01667462,
-0.013888883,
0.010890901,
0.028334914,
0.008881192,
0.0014334932,
-0.006599541,
-0.010274059,
0.0029863752,
0.003435741,
0.015387874,
-0.020879753,
-0.017032785,
-0.028016543,
0.0069245435,
-0.022869565,
0.025867548,
0.0066658678,
0.0008460844,
0.0043079415,
-0.01040008,
-0.036055382,
0.00924599,
-0.0005708271,
0.032049228,
0.025668567,
0.011123045,
-0.002628209,
0.0022269306,
0.031279836,
0.00555489,
-0.00080836087,
0.04242278,
0.033800263,
-0.037832946,
-0.006383978,
-0.011129678,
-0.009769973,
0.012177645,
0.025933875,
-0.016342985,
0.010201099,
0.008576087,
0.0061518336,
-0.0048617725,
0.015109301,
0.015799101,
0.020216484,
0.012641935,
0.023506304,
0.0418391,
0.028149197,
0.012442954,
-0.018651165,
0.002805634,
-0.01915525,
0.025734894,
-0.033004336,
-0.017470544,
-0.006539847,
0.012091421,
-0.00696434,
0.0017659576,
-0.02785736,
0.0030394369,
0.00400947,
-0.021317512,
0.0036911,
-0.026650207,
0.0050508045,
0.050833046,
-0.02820226,
-0.024527742,
0.016289921,
0.012462852,
0.03273903,
-0.0125291785,
-0.014512357,
0.0011001999,
0.029714515,
0.007793428,
0.008105164,
-0.00902711,
0.021078736,
-0.005594686,
0.015984818,
-0.0014840676,
-0.011215903,
0.010658756,
0.0024143045,
0.005753871,
0.023983859,
0.015998082,
-0.020654242,
0.015135831,
-0.03308393,
-0.00067943765,
-0.0059296377,
-0.03788601,
-0.00025805365,
0.022060376,
-0.026424695,
-0.011673559,
-0.005336011,
0.00689138,
0.02060118,
0.015003177,
0.0295288,
-0.0020080514,
0.00956436,
-0.008748537,
0.03334924,
-0.024222637,
-0.0006487614,
0.012336831,
0.012502648,
0.017948098,
-0.029343085,
-0.018889943,
0.005986016,
-0.0050209574,
0.01103682,
-0.0070571974,
0.028759407,
0.018531777,
0.009066907,
-0.002051164,
0.009750076,
-0.012675098,
-0.00885466,
-0.0048252926,
-0.018399121,
0.035498235,
0.010320488,
0.016263392,
0.0048153433,
-0.002483948,
-0.029926762,
-0.0009915893,
0.013902148,
0.00061891426,
0.04409422,
0.0021092,
-0.016860334,
0.019009331,
-0.004622995,
-0.0010206074,
0.02984717,
-0.017616464,
-0.011335292,
-0.0040061534,
0.024089983,
-0.0016789034,
-0.6299477,
-0.011394986,
0.0009542804,
-0.0105592655,
0.018425653,
0.017298093,
0.009597523,
-0.00090453506,
-0.0028504047,
0.027830828,
-0.018014425,
0.00061145244,
0.014817461,
-0.040645212,
-0.015931755,
-0.022259356,
0.0015097694,
-0.0046163625,
0.029794108,
-0.0041288584,
-0.034171693,
0.0018322846,
0.015096036,
0.015308282,
-0.0013406354,
0.011308761,
0.007806693,
-0.010871002,
0.000040599407,
0.019513417,
-0.023506304,
0.02219303,
-0.010532735,
-0.011182739,
0.03958398,
0.0037308962,
-0.014300111,
0.040963583,
0.0101878345,
0.0058964742,
-0.00004420076,
-0.013663371,
0.011773051,
0.008058736,
-0.008768436,
0.039769694,
0.014645011,
-0.0012842574,
0.0044107484,
-0.01961954,
-0.013099591,
-0.004792129,
-0.012502648,
0.021662412,
-0.015268486,
-0.008450066,
0.01996444,
-0.02219303,
0.013139388,
-0.003774009,
-0.009385277,
0.021131797,
-0.0025834383,
-0.010035282,
-0.013557248,
-0.0035916094,
-0.011023555,
0.024050185,
0.008416902,
-0.008343942,
0.01030059,
0.021450166,
-0.0012850865,
-0.0012925483,
-0.004188553,
0.030722687,
-0.00025763913,
-0.013676637,
0.006098772,
0.043377887,
0.008483229,
0.003644671,
-0.015918491,
-0.013079694,
0.034304347,
-0.0073291385,
-0.008350575,
0.021675678,
0.00720975,
0.0189828,
0.00035795878,
-0.013968475,
-0.0032732396,
-0.028308382,
-0.029502269,
-0.0018588154,
0.012575608,
0.0026149438,
0.017231766,
-0.018226672,
-0.014048068,
0.00998222,
0.015202159,
0.00008684697,
0.013902148,
-0.0044737593,
-0.052026935,
0.0066990317,
0.035869665,
-0.011812846,
-0.011056718,
-0.01040008,
-0.009763341,
0.008695476,
0.00091945863,
-0.018744024,
0.007229648,
0.020906284,
-0.001026411,
-0.03279209,
0.0074883234,
0.014339907,
0.007229648,
-0.014512357,
0.0018007793,
0.014830727,
0.012708262,
-0.036824774,
0.008111797,
0.011023555,
0.013968475,
0.013809291,
0.015387874,
-0.013676637,
0.028998183,
0.023612428,
0.044996265,
0.021025673,
0.00023608282,
-0.032128822,
-0.022988955,
-0.011567436,
-0.0049115177,
-0.0038337032,
-0.016223595,
-0.02658388,
-0.022590991,
-0.0023794826,
0.00020343748,
0.01030059,
0.003324643,
0.0021058836,
-0.017417481,
0.013013366,
0.01961954,
-0.0015238639,
-0.04085746,
-0.043218702,
0.0019384079,
0.004752333,
-0.00054346723,
0.021450166,
-0.0055582062,
0.026199182,
-0.0019782041,
-0.023466509,
-0.008503127,
0.0016200381,
-0.0029913497,
-0.013119489,
-0.0004319549,
-0.00035795878,
-0.00081665174,
-0.009677116,
-0.0036645692,
0.010121507,
-0.0073357713,
-0.021423636,
-0.009902628,
-0.006138568,
0.010260793,
-0.0056643295,
-0.02123792,
-0.015308282,
-0.0069046454,
0.03634722,
0.03990235,
-0.014127661,
0.004211767,
0.038761526,
-0.001110149,
0.012694997,
0.0022236141,
0.021450166,
0.01866443,
-0.008317411,
0.020322606,
-0.011560804,
-0.008735272,
0.01736442,
0.005292898,
-0.030377787,
0.009829668,
-0.041281953,
0.015188893,
0.0050806515,
-0.0049115177,
-0.012496015,
0.0117929485,
0.01869096,
-0.010678655,
0.00787302,
-0.009060274,
-0.017616464,
-0.00393651,
0.0030079314,
0.0013514135,
0.011501109,
-0.008489862,
-0.023294058,
-0.0114812115,
-0.0037474781,
0.02219303,
0.011262332,
-0.015135831,
0.027538989,
-0.017444013,
-0.006261273,
-0.0059528523,
0.011892439,
0.011348558,
-0.011308761,
0.0030659677,
0.008085267,
0.001431006,
0.012522546,
-0.011295496,
-0.0021622616,
0.04022072,
-0.009849566,
-0.012774589,
0.008350575,
-0.023559365,
-0.028971653,
0.013172551,
-0.0072429134,
0.022126703,
-0.0067819403,
-0.023121608,
0.022498133,
-0.008894457,
0.01768279,
-0.022352215,
-0.004125542,
-0.016396046,
-0.004851823,
0.019526683,
0.019911379,
0.026557349,
0.013000101,
0.005478614,
-0.0038104886,
0.013053162,
0.0048717214,
0.0011715015,
0.02022975,
0.011779683,
-0.0039132955,
0.015759306,
-0.0037872742,
-0.029979825,
0.005647748,
0.006281171,
-0.013298572,
0.035498235,
0.0062645893,
-0.003220178,
0.033243116,
-0.009033743,
0.021861393,
-0.008456699,
-0.01719197,
0.032579843,
0.016979724,
-0.030696156,
-0.009730177,
-0.032712497,
-0.00033246432,
-0.021662412,
0.01785524,
-0.006798522,
0.010459775,
-0.01525522,
0.01768279,
0.0033461994,
-0.024089983,
0.023638958,
-0.031439018,
0.02562877,
-0.009624054,
0.008655679,
-0.00467274,
-0.013431227,
0.0028487465,
0.05290245,
0.004225033,
-0.011766418,
0.02562877,
-0.003512017,
-0.019884847,
-0.009750076,
-0.005667646,
0.0022086906,
-0.0149899125,
-0.006241375,
0.008012307,
-0.0054653483,
0.021940986,
0.022803238,
-0.010725083,
-0.009378644,
-0.038708463,
-0.0020478475,
0.017576667,
0.011249066,
0.03571048,
-0.010174569,
0.00061020884,
0.007859754,
0.011587335,
-0.0059263213,
-0.025588974,
0.014897054,
-0.0074418946,
0.0010181201,
-0.018916473,
0.028918592,
0.0011839378,
0.025761424,
0.003190331,
-0.010884268,
-0.030351255,
-0.0057505546,
-0.014353173,
0.008231186,
0.0014500751,
0.006546479,
0.028839,
0.032898214,
-0.007448527,
0.018558307,
0.016011348,
0.01895627,
-0.0334023,
0.016329719,
0.017589932,
-0.020256279,
0.01670115,
-0.0036081912,
-0.002314814,
0.010061813,
-0.0027791031,
0.022179764,
0.017536871,
0.022657318,
0.020388933,
0.0051934076,
0.0067454604,
0.010645491,
-0.009365379,
-0.012509281,
-0.0035949259,
0.014021537,
-0.028255321,
0.013417961,
-0.014751134,
-0.02123792,
-0.0196726,
0.0070571974,
-0.002890201,
-0.024222637,
0.008430167,
0.0032981122,
-0.018717492,
-0.0061684153,
-0.013099591,
0.019858317,
-0.004387534,
-0.0016755869,
0.008794966,
-0.0020577966,
0.006582959,
-0.04860446,
-0.008668945,
0.007833224,
-0.038469687,
-0.03016554,
-0.0057870345,
0.024554271,
0.03828397,
0.016767478,
-0.045341168,
0.030139009,
0.023280792,
-0.03568395,
-0.009066907,
0.004510239,
-0.027990013,
-0.020441996,
-0.0082842475,
0.0013638498,
-0.01719197,
-0.004812027,
-0.0046561584,
0.022471603,
-0.0015959945,
-0.013941945,
0.010599062,
0.013530717,
0.03313699,
0.018651165,
0.035524767,
0.0008539607,
-0.014034803,
-0.0022717013,
0.0018339428,
0.00934548,
-0.026278775,
0.0024822897,
-0.03345536,
-0.012376627,
0.008111797,
0.0036678857,
-0.011872541,
0.014233784,
-0.0013729698,
0.009849566,
0.034781903,
0.021994049,
0.011739887,
-0.012595505,
0.02317467,
0.001685536,
0.007276077,
0.016276658,
-0.012748058,
0.04380238,
0.012602138,
-0.0037806416,
0.018624634,
-0.015878694,
-0.020189952,
-0.018332794,
0.01574604,
0.018531777,
0.05125754,
-0.002994666,
-0.041043174,
-0.010479673,
-0.011965399,
-0.014724604,
-0.0038569176,
-0.0000290699,
-0.00028064632,
-0.016780742,
0.005594686,
0.0007561283,
0.0022667267,
0.0039132955,
-0.033216584,
-0.022285886,
0.0028222157,
0.02982064,
0.02643796,
0.0059362706,
-0.0113618225,
-0.031624734,
-0.010758246,
-0.0041288584,
-0.016117472,
-0.002024633,
-0.022750176,
0.027061434,
0.006778624,
0.030218601,
-0.005528359,
0.008184757,
0.01797463,
-0.004284727,
0.0071898517,
0.0044737593,
0.013212347,
-0.018266467,
0.0070041358,
0.029449208,
-0.008861293,
0.01361031,
-0.014366438,
-0.0008738588,
0.020468526,
-0.033614546,
0.0015578564,
0.005375807,
-0.016833805,
-0.022988955,
0.016515434,
-0.01869096,
-0.00770057,
-0.03273903,
-0.013809291,
0.034304347,
-0.008794966,
0.007050565,
-0.008503127,
0.014512357,
-0.006102088,
0.008940886,
-0.013039897,
-0.0013729698,
-0.009119969,
-0.024660395,
-0.021795066,
-0.007839857,
0.011706723,
-0.017258298,
0.009299052,
0.022551196,
-0.01667462,
0.0023977226,
0.00055880536,
-0.015812367,
0.008244452,
-0.009902628,
-0.0019052443,
-0.012376627,
-0.022803238,
-0.006546479,
-0.030404318,
0.020680772,
0.01910219,
0.002185476,
0.031094119,
-0.020906284,
-0.025721628,
0.031306364,
-0.0012817702,
0.029396147,
0.00052191096,
0.020972611,
0.012210809,
-0.009113336,
-0.0425289,
-0.010148038,
0.01103682,
-0.00034987516,
0.03181045,
0.00917303,
0.0047888127,
0.0049015684,
-0.0019798623,
-0.014578684,
-0.014950116,
-0.032261476,
0.02332059,
-0.03433088,
0.0055316756,
0.000037283055,
0.019407293,
-0.0014749477,
0.015626652,
-0.045553416,
0.014777666,
-0.011925602,
-0.026238978,
-0.0057505546,
0.012350095,
0.010061813,
-0.0026431328,
-0.011328659,
-0.002493897,
-0.011441415,
-0.010161303,
-0.022259356,
0.000020144249,
-0.0043576867,
0.034543123,
0.018425653,
-0.011302128,
0.006742144,
0.017032785,
-0.017099112,
-0.021994049,
-0.0043377886,
0.03600232,
-0.012058257,
0.0031953054,
0.007674039,
0.030643094,
-0.0015578564,
0.01834606,
-0.010605695,
-0.0056079514,
-0.027273681,
0.0057936674,
0.01542767,
0.0028421138,
-0.0033329339,
-0.016648088,
-0.02889206,
0.0037209473,
-0.028441036,
-0.029130839,
0.016886866,
-0.03889418,
-0.0054189195,
-0.00043527124,
0.038124785,
0.017895037,
0.013490921,
0.0044737593,
-0.020216484,
0.04438606,
0.0006587105,
0.004377585,
0.0038933975,
-0.022166498,
-0.012343463,
-0.011713356,
-0.025854282,
-0.030934934,
-0.0020644292,
-0.015918491,
-0.025124684,
0.011865908,
-0.0075281197,
0.0032798722,
-0.0014053043,
-0.03334924,
0.019195046,
0.0040360005,
0.01814708,
-0.002739307,
-0.015799101,
0.03366761,
-0.0022584358,
0.021476697,
-0.0020577966,
0.0078000603,
-0.029236961,
0.007475058,
-0.037832946,
-0.01805422,
0.0033859955,
-0.007375567,
-0.013650105,
0.0016739288,
-0.011905705,
0.003331276,
0.010599062,
-0.0065763267,
-0.010539368,
0.023625692,
-0.0010711817,
-0.0020942765,
-0.028122667,
-0.006204895,
0.034092102,
0.009458236,
-0.011965399,
-0.004904885,
0.017908301,
-0.014830727,
-0.022697115,
-0.0021042256,
-0.026411429,
0.019685866,
0.0013887224,
-0.008662312,
-0.0007892918,
-0.0018870045,
-0.061127003,
-0.020256279,
0.016740946,
0.024089983,
0.023877736,
0.021277716,
0.0034291083,
-0.0207471,
-0.0033594647,
0.015016443,
-0.015268486,
-0.0121577475,
0.026835922,
0.018253203,
0.012058257,
0.026451224,
-0.039822757,
-0.009763341,
0.039530918,
-0.026411429,
-0.037355393,
0.023201201,
-0.021344043,
0.022484869,
-0.016953193,
-0.002862012,
-0.0072827097,
0.015785836,
0.026039997,
-0.015838899,
-0.03926561,
0.018863412,
0.000317748,
-0.027698174,
0.006662552,
0.0070174015,
0.020402199,
0.011209271,
-0.018571572,
-0.0014907003,
0.011660295,
-0.008390371,
0.016077675,
0.032579843,
-0.010950595,
0.0098827295,
0.028679814,
-0.029900232,
-0.012549077,
-0.016011348,
0.0050640698,
-0.011010289,
0.0072827097,
0.006785257,
-0.010771512,
0.0054454505,
-0.0068980125,
-0.028918592,
0.010711818,
0.014963381,
-0.018730758,
-0.03268597,
-0.0008183099,
0.0070969937,
-0.029767578,
0.011514375,
-0.000053631633,
-0.017762383,
0.0028122666,
-0.011806214,
-0.027485928,
-0.005226571,
0.009889362,
-0.00033909702,
-0.01716544,
-0.018332794,
-0.00696434,
-0.024554271,
-0.053353474,
0.016051145,
0.1778626,
-0.0351268,
-0.0138225565,
0.017444013,
0.00980977,
-0.022577725,
0.008542923,
-0.0036612528,
-0.029316554,
0.014923585,
0.021569556,
0.006563061,
-0.020256279,
-0.001375457,
0.012396525,
-0.000019949932,
-0.0558739,
0.004699271,
-0.035869665,
0.032500252,
-0.021251185,
0.0057406058,
-0.007826591,
-0.00850976,
0.008410269,
0.0070174015,
-0.019805256,
-0.0017841975,
-0.008324044,
-0.015560324,
-0.021715475,
-0.023055281,
-0.015772572,
-0.0098827295,
0.007037299,
-0.012224074,
0.011448048,
-0.0017626412,
-0.008901089,
-0.009650585,
0.000049175287,
0.0428738,
0.0053990213,
-0.018014425,
0.00072379387,
0.03207576,
-0.005233204,
-0.011620498,
-0.03669212,
-0.013358267,
-0.03894724,
0.0025917292,
0.011846011,
0.007859754,
0.002202058,
-0.014777666,
0.022511398,
0.004377585,
-0.00836384,
0.0249655,
-0.030298194,
-0.0073490366,
-0.01361031,
0.025031827,
-0.020097094,
0.026066529,
-0.025058357,
-0.0038834484,
0.02432876,
-0.03414516,
-0.013902148,
-0.011972032,
-0.008025573,
-0.007607712,
-0.0069975033,
-0.0038933975,
0.023055281,
-0.00030800622,
-0.013338368,
0.015613386,
-0.013796025,
-0.016488904,
-0.02854716,
-0.014976647,
0.007030667,
-0.036426812,
0.0117929485,
0.014963381,
0.01883688,
0.011733254,
0.008310779,
-0.014830727,
-0.0065663774,
0.01849198,
0.0010288983,
0.013623575,
-0.0050043757,
-0.020256279,
-0.012794487,
-0.050726924,
-0.021158326,
0.075718954,
-0.015732775,
0.006516632,
-0.019911379,
0.017258298,
0.0023330539,
-0.0107449815,
0.0026796125,
-0.006864849,
0.0084036365,
-0.022551196,
-0.0035717112,
-0.007388833,
0.010366917,
0.000828259,
0.013351634,
-0.0418391,
0.047596287,
-0.009444972,
0.016077675,
-0.014034803,
0.010605695,
-0.007826591,
0.0079725105,
-0.00041330038,
-0.032022696,
0.01361031,
0.011288863,
-0.029396147,
0.010360285,
-0.010327121,
-0.02175527,
0.007780162,
0.00007705337,
-0.0068316855,
0.0092061935,
-0.009690382,
-0.0013530717,
0.013152653,
0.00028790082,
0.0064270906,
0.0022302468,
0.0032898213,
-0.0072561787,
-0.031014526,
0.022206295,
-0.009849566,
0.008357207,
-0.0036745183,
-0.023997124,
-0.012316932,
0.007919449,
-0.0014732894,
0.015852164,
-0.0004576566,
-0.029661454,
-0.026849188,
-0.015069504,
0.009690382,
-0.039796226,
0.007448527,
0.012774589,
-0.027963482,
0.003306403,
0.010141405,
-0.1659768,
0.0061717313,
0.009106703,
-0.018359326,
0.05582084,
0.005657697,
0.04510239,
0.016966458,
-0.0050242734,
-0.0021805016,
0.015135831,
-0.00049745286,
-0.0383105,
-0.024660395,
-0.025297135,
0.004414065,
-0.011487844,
0.013809291,
0.008244452,
-0.014751134,
0.035206396,
-0.011089882,
-0.006977605,
-0.013875618,
-0.014114395,
0.007866387,
0.0069179107,
-0.023798143,
-0.008416902,
0.00052108185,
-0.0172185,
0.017152173,
0.03868193,
-0.009060274,
0.028122667,
0.016661353,
0.013796025,
-0.02077363,
-0.0104398765,
0.009259256,
-0.011189372,
0.02371855,
0.006224793,
-0.023055281,
0.0020495057,
-0.0019201679,
0.02533693,
-0.004095695,
0.004440596,
0.005269684,
-0.0012743083,
0.007926082,
0.010652123,
0.022577725,
0.011978664,
0.011408252,
0.0056046355,
0.020760365,
-0.017749118,
-0.023612428,
0.0016183798,
-0.017536871,
0.024434883,
-0.008237819,
0.0025386675,
-0.032341067,
-0.016900131,
-0.00344569,
-0.023386916,
0.012794487,
-0.023731817,
-0.007614345,
0.012078155,
-0.0050441716,
0.020866489,
0.009411807,
-0.0026779545,
0.025841016,
-0.008867926,
-0.009385277,
-0.025535911,
0.022378745,
-0.032208413,
-0.018558307,
0.012104685,
-0.013172551,
0.012442954,
0.009650585,
0.0010968836,
-0.013902148,
0.017895037,
-0.02722062,
0.004649526,
-0.01670115,
0.012940407,
0.0073424038,
-0.0013422936,
-0.022644052,
-0.007428629,
-0.00040169316,
0.00770057,
-0.01785524,
-0.011209271,
0.033004336,
0.0295288,
0.013504187,
-0.0053625414,
0.00826435,
0.054706547,
0.0018405755,
0.022113437,
0.013875618,
0.009796505,
0.046694238,
-0.008761803,
0.02094608,
-0.0055482574,
-0.012210809,
-0.018399121,
0.011773051,
0.074816905,
0.0020660874,
0.0068383184,
0.03273903,
0.017085847,
-0.040645212,
-0.14241743,
-0.011388354,
-0.008722006,
0.021994049,
-0.00794598,
0.03860234,
-0.009458236,
0.032632906,
0.0012552394,
0.028016543,
-0.0002103811,
0.011142943,
-0.00006497977,
-0.009047009,
-0.013338368,
-0.012661832,
0.0013480972,
-0.0043510543,
-0.02889206,
0.03403904,
0.014061334,
0.015971553,
0.0081582265,
-0.013809291,
0.004211767,
-0.022285886,
-0.02854716,
0.014658277,
0.006539847,
-0.0014525623,
0.018770553,
-0.020004237,
0.0011781341,
-0.009942424,
-0.004304625,
0.011846011,
-0.006178364,
-0.017284827,
0.02984717,
0.01765626,
-0.006221477,
0.0017576667,
0.0029117572,
-0.0014185697,
0.008377106,
-0.005213306,
-0.019208312,
0.02060118,
-0.026491022,
-0.010015383,
-0.020388933,
0.009166397,
-0.024660395,
-0.015878694,
0.0076209772,
-0.011043453,
0.0152419545,
0.02332059,
-0.009186296,
0.0008829788,
0.011540906,
-0.004095695,
0.0013232245,
0.02484611,
0.024607334,
-0.009796505,
-0.010751614,
-0.017749118,
0.027618581,
-0.046322808,
0.0019632806,
0.02793695,
-0.013192449,
-0.01216438,
-0.02479305,
0.01903586,
-0.035896197,
-0.0036015585,
0.0035617624,
-0.008556189,
-0.005528359,
-0.024116514,
0.0043245233,
-0.014525623,
-0.00028188995,
0.025443055,
0.005783718,
-0.0061717313,
0.011693458,
-0.011295496,
-0.017895037,
0.031545144,
-0.022789972,
-0.018120548,
-0.0025154531,
0.023612428,
-0.021277716,
-0.026066529,
0.009060274,
0.004530137,
-0.02155629,
-0.014538888,
-0.045633007,
0.0193277,
-0.011713356,
-0.016250126,
0.022484869,
-0.012144482,
0.0074816905,
0.0057107587,
0.013577146,
0.015520529,
-0.03146555,
-0.008794966,
0.004679373,
-0.00066161226,
-0.010386815,
0.008867926,
0.018505245,
0.0014160824,
0.014074598,
0.022988955,
-0.025761424,
-0.003021197,
0.007707203,
0.02028281,
0.0006935322,
-0.021450166,
-0.012542444,
0.0014907003,
-0.015109301,
0.0037176309,
0.004387534,
-0.008456699,
-0.012356728,
0.008768436,
-0.039212547,
-0.0032699234,
-0.011759785,
0.015613386,
0.016555231,
0.048471805,
-0.008523026,
-0.04597791,
0.0050209574,
0.0059362706,
0.019062392,
-0.012403158,
-0.028785937,
0.004168655,
-0.000121046854,
-0.037408452,
0.013457757,
0.005986016,
-0.004828609,
-0.020163422,
-0.006762042,
0.012668465,
0.014804197,
-0.017457278,
0.0045898315,
-0.004397483,
0.03634722,
0.005866627,
0.00664597,
-0.01522869,
0.015334813,
-0.007223015,
-0.014127661,
-0.005989332,
0.02646449,
-0.028759407,
-0.016740946,
0.028122667,
0.020521587,
-0.0016905105,
-0.0040724804,
0.0057571875,
-0.000027023088,
0.03563089,
0.0011308761,
0.007130157,
0.016913397,
0.008324044,
-0.032818623,
0.019115454,
0.027777767,
-0.008078634,
0.0020677457,
0.020388933,
0.0007722955,
0.0024259116,
0.0019500151,
0.021131797,
0.007713835,
0.0055615227,
0.00035795878,
0.020349137,
0.004868405,
-0.017032785,
-0.0017444013,
0.021543024,
0.0023114975,
0.012018461,
-0.0056643295,
-0.022564461,
-0.012131216,
0.030032886,
-0.050037123,
-0.037726823,
-0.018717492,
-0.01849198,
0.0025088205,
-0.002364559,
0.004997743,
0.004765598,
-0.010526102,
0.002014684,
-0.016342985,
-0.0026016783,
-0.00045724207,
0.021078736,
0.017841974,
0.037063554,
0.006599541,
0.0094914,
0.0059462194,
0.012396525,
0.03441047,
-0.0291839,
0.008151594,
-0.011719989,
0.00063217967,
-0.010453142,
-0.041255422,
-0.012568975,
-0.015268486,
0.0078000603,
0.00019680477,
0.012814385,
0.0013820898,
0.069829114,
0.007368935,
-0.0039696735,
0.008861293,
0.0033263012,
0.030059416,
0.019752193,
0.023015484,
-0.0031024476,
-0.014843993,
0.019367497,
-0.025695097,
0.019049127,
-0.015878694,
-0.0010487963,
0.023917532,
-0.0007623465,
0.021940986,
-0.012104685,
-0.022763442,
0.020362403,
0.0017145541,
0.016634822,
0.015838899,
-0.026769595,
-0.0010662072,
0.046216685,
-0.0068316855,
0.006748777,
-0.016740946,
0.01609094,
-0.022100171,
-0.035816602,
0.023638958,
0.003926561,
-0.018704226,
-0.007561283,
-0.00924599,
0.01508277,
0.00636408,
0.017576667,
-0.02337365,
-0.0062181605,
-0.0087817,
-0.0068980125,
-0.003850285,
0.006440356,
0.0085296575,
-0.030934934
] |
The list of preventable and reversible risk factors for atherosclerotic cardiovascular disease continues to grow. Cigarette smoking, high blood pressure, physical inactivity, elevated cholesterol, underlying lipoprotein abnormalities, lipoprotein(a), diabetes, overweight, male gender, and age are well-established risk factors. During the 1990s, there have been many reports associating elevated plasma homocysteine levels with arteriosclerotic cardiovascular disease and consistent evidence that dietary and supplemental folic acid can reduce homocysteine levels.1 2 The article by Robinson and colleagues3 in this issue of Circ | [
-0.012152058,
-0.013106442,
0.013557487,
-0.034305543,
-0.030566446,
0.02379424,
-0.013727446,
0.016159166,
-0.032684393,
-0.004111697,
-0.0034089824,
0.013897405,
-0.014158879,
0.0008808444,
-0.0035658674,
0.0076350747,
0.05187667,
-0.0050007124,
0.02337588,
-0.011596424,
-0.030775627,
0.024225673,
0.00852409,
-0.022722192,
0.005353704,
0.016708262,
0.016433714,
-0.050595444,
-0.02601678,
-0.026827352,
0.01530937,
-0.008327984,
-0.012766524,
-0.011106158,
-0.017937196,
0.009674581,
-0.014629535,
-0.0023303973,
-0.0028729583,
-0.015047896,
0.0030249408,
0.0044352724,
-0.00041223192,
-0.006036808,
-0.012812283,
-0.0029514008,
0.000650828,
-0.006553221,
-0.028762268,
0.041286927,
0.032161444,
0.01005372,
0.008805176,
-0.0015198244,
0.0025003562,
0.014276544,
0.0055890316,
0.025114689,
0.0065761004,
-0.019440679,
-0.011969025,
0.0030657963,
-0.023049036,
-0.0012150424,
-0.029546693,
0.032815132,
0.008635217,
0.033756442,
-0.00059608166,
0.02379424,
0.009315053,
0.019440679,
-0.0026654124,
0.0067199115,
-0.0052229664,
0.011563739,
-0.039404307,
-0.0146164615,
0.0026278254,
0.00071742246,
0.024761697,
-0.018211745,
-0.017296582,
0.019924408,
0.0389075,
-0.0075435583,
-0.0022437838,
0.016969739,
0.0017829337,
-0.009909908,
0.0030445515,
0.017754164,
-0.003028209,
0.006817965,
-0.0030249408,
0.018172523,
0.012498513,
0.018525515,
-0.009818392,
0.004968028,
-0.0138320355,
-0.017610352,
-0.009498085,
-0.008831323,
-0.025206205,
-0.0043829773,
-0.02873612,
0.012132447,
-0.008471795,
-0.011753309,
0.004288193,
0.050752327,
0.0042032134,
-0.036345046,
0.019976702,
-0.030148085,
0.0036246993,
0.007007534,
0.002760197,
-0.0084521845,
0.0044058566,
0.019022318,
0.022905223,
-0.007072903,
0.0003292953,
-0.0039580804,
-0.039770372,
0.0032226813,
-0.0063473093,
0.0073670624,
-0.009792245,
0.009112409,
0.010713944,
-0.0064518997,
-0.047039382,
0.007295157,
-0.024094936,
-0.0067722066,
-0.012302406,
-0.034933083,
-0.01294302,
0.022016209,
-0.022133872,
-0.0011325143,
0.006857186,
0.017924123,
0.038672175,
0.014734125,
0.011589887,
-0.0061413976,
-0.0084521845,
-0.015610067,
0.021610921,
-0.034305543,
-0.008406427,
-0.0017829337,
-0.024983952,
0.0065761004,
-0.012472365,
-0.0044483463,
0.015884615,
0.007125198,
0.013217569,
0.022421494,
-0.007726591,
0.0045039095,
-0.004023449,
0.0017191991,
0.005716501,
0.0039744223,
-0.01795027,
0.030461855,
-0.01795027,
0.008426037,
0.008582922,
0.024408706,
0.0073735993,
0.016472936,
-0.036135867,
-0.03715562,
-0.021454036,
0.016433714,
0.05041241,
0.014289618,
-0.013544413,
0.018590884,
0.029102186,
-0.021454036,
0.011406854,
-0.03579595,
-0.0069487025,
0.015819248,
-0.01930994,
-0.04275119,
-0.642183,
-0.012903799,
-0.00915163,
0.0036246993,
0.020891866,
0.036345046,
0.02121871,
0.011674866,
-0.012759988,
0.025925262,
-0.010177921,
0.03051415,
0.025689935,
-0.003108286,
-0.002111412,
-0.034174804,
-0.003889443,
-0.0010156676,
-0.006752596,
0.0114591485,
0.0073735993,
0.0007578694,
-0.026657393,
-0.005422341,
0.032292183,
0.033416525,
0.00029661087,
-0.036188163,
-0.01478642,
0.006507463,
0.022905223,
0.019074613,
-0.0073082307,
0.021872398,
0.047222413,
-0.00569689,
-0.002603312,
0.033939477,
0.013119516,
0.015610067,
-0.0035299147,
-0.009413105,
0.005471368,
0.003279879,
0.0032259498,
0.020473504,
0.014799494,
0.0038110004,
0.001092476,
0.011341485,
-0.0020918013,
-0.010380564,
-0.020617316,
-0.009315053,
-0.0035233777,
0.0074258945,
0.028003989,
-0.03579595,
-0.00049925415,
0.012655398,
-0.011210747,
0.012871115,
-0.018420925,
-0.016655969,
-0.00023737042,
0.010589744,
-0.020617316,
0.0023875951,
0.011589887,
0.00076113787,
0.008504479,
0.022016209,
-0.01374052,
-0.014485724,
0.036789555,
0.0105047645,
0.011086547,
0.016499082,
-0.03145546,
-0.00013175896,
0.007301694,
0.017924123,
-0.0017224676,
0.0025689935,
0.012988779,
0.0149302315,
0.0016448422,
-0.010021036,
0.006023734,
-0.0049778335,
0.017518835,
-0.008458721,
-0.015427034,
-0.021297151,
-0.010393637,
0.011034252,
0.0065499526,
0.01108001,
-0.0055824947,
0.003673726,
-0.0252585,
-0.016407566,
-0.013224106,
0.017911049,
0.009047041,
-0.0030952122,
-0.027559482,
-0.0139497,
0.020865718,
-0.024434853,
0.011361096,
-0.00718403,
-0.011877509,
-0.03328579,
-0.0004902659,
-0.017453467,
-0.005399462,
-0.013184885,
0.007242862,
-0.037940044,
0.007876939,
0.010674723,
-0.0010083136,
-0.0136620775,
0.0047817267,
0.01798949,
0.008517553,
-0.007295157,
0.019323014,
-0.04306496,
0.011635644,
0.008171098,
0.013400602,
-0.0043862457,
0.008680975,
-0.023140552,
0.01951912,
0.025506902,
-0.009197389,
-0.017126624,
-0.0138320355,
-0.009681118,
0.0006299917,
-0.010119089,
-0.0069160177,
-0.020800348,
0.018486293,
0.009962204,
0.0067787436,
0.00038792292,
0.0043339506,
-0.022120798,
-0.016250681,
0.029729726,
-0.005353704,
-0.008844397,
0.0055759577,
-0.01367515,
0.015596993,
-0.004092086,
0.007242862,
-0.011452612,
-0.021205636,
0.0050530075,
-0.0032308525,
-0.010001425,
-0.0002610666,
0.0047555794,
-0.010583207,
-0.016263755,
0.0010279242,
-0.02104875,
-0.008393353,
0.020447357,
-0.011151915,
0.024866289,
-0.008981672,
0.013753593,
-0.007563169,
0.0023696187,
0.0049418807,
-0.038515292,
-0.018067934,
-0.0034024455,
0.02222539,
-0.0040397914,
0.029102186,
0.0015181901,
0.0034024455,
0.033207346,
-0.009125483,
0.013400602,
-0.01572773,
-0.007197104,
0.007837718,
-0.0073213046,
-0.0053373617,
0.000047851998,
0.0131914215,
0.015949985,
0.011263043,
-0.01899617,
0.018250966,
-0.016577525,
0.018983096,
-0.023035962,
-0.0043012663,
-0.0054419516,
0.0010573402,
0.0068898704,
0.014001994,
0.014564167,
-0.017126624,
-0.010903514,
-0.0048830486,
-0.002551017,
0.012250111,
-0.012694619,
0.009079725,
-0.0072101774,
0.010517838,
-0.008432574,
0.016590599,
-0.024644034,
-0.0032602684,
0.02532387,
0.010543986,
0.016655969,
-0.00789655,
-0.020473504,
-0.016472936,
-0.0033076608,
0.0008432574,
0.009053578,
0.019728301,
0.0013147298,
0.0041836025,
-0.013753593,
0.019571416,
0.02473555,
-0.004010375,
-0.0011137207,
0.0146164615,
0.014459576,
-0.0010908417,
-0.026801204,
0.03297202,
0.028500792,
0.0095569175,
0.013289475,
0.015335518,
-0.0049451487,
0.0033893718,
0.0010532546,
-0.019336088,
-0.001517373,
0.014668756,
0.0046673315,
0.039848816,
0.016930517,
0.029755874,
0.004425467,
-0.01149837,
-0.004500641,
-0.011870972,
0.014538019,
-0.008988208,
-0.0025101616,
-0.00018865024,
0.021401742,
-0.029520545,
-0.0040397914,
-0.02504932,
-0.03252751,
0.016499082,
0.029128334,
0.012478902,
0.01170755,
0.027193416,
0.016028427,
-0.0023532764,
-0.0273503,
0.028291613,
0.041600697,
-0.01363593,
-0.00031070603,
-0.0016497448,
-0.00481768,
-0.0030919437,
0.025245426,
0.008491406,
0.0021016067,
0.013145664,
-0.0141327325,
-0.02205543,
-0.018277114,
0.03305046,
-0.014381134,
0.026984237,
-0.02094416,
-0.014171953,
-0.020447357,
-0.014812568,
0.0078050336,
0.044058565,
0.03273669,
0.02184625,
0.032579806,
0.011596424,
-0.004193408,
0.016015353,
-0.012393923,
-0.0005053824,
-0.00021408279,
0.002423548,
0.025493829,
-0.019414531,
-0.012511587,
0.0053373617,
-0.023153625,
-0.0040495964,
-0.028788416,
-0.01325679,
-0.0131979585,
0.03924742,
-0.0040267175,
0.0016726239,
0.007942308,
0.007667759,
0.0029563035,
-0.0056184474,
-0.029546693,
0.021859324,
0.011877509,
0.028187022,
-0.007229788,
0.02431719,
0.004771922,
0.01847322,
0.020028997,
-0.004193408,
-0.030069644,
0.012276258,
-0.013276401,
0.003072333,
-0.025441533,
0.011642181,
0.041313075,
0.03597898,
0.006291746,
0.02000285,
0.021754732,
0.0013768302,
0.0075827795,
-0.019349162,
0.023558911,
0.001717565,
0.013067221,
0.003860027,
0.0042522396,
-0.012537734,
0.0018254234,
0.007523948,
0.0048961225,
0.021820102,
0.00718403,
0.008968598,
0.010864293,
-0.0036279678,
-0.025899114,
0.020852644,
0.0020656537,
0.00768737,
-0.025114689,
0.014185027,
0.012596566,
0.0021702438,
-0.012308943,
0.023859609,
-0.03935201,
0.021767806,
-0.018538589,
-0.015322444,
0.009099335,
-0.015008674,
-0.0008028105,
0.0095503805,
-0.013805889,
-0.0025542856,
0.012701156,
-0.0049582226,
-0.0012150424,
-0.0063538463,
0.008092656,
0.025964484,
0.019336088,
-0.021545554,
0.005540005,
-0.008537164,
0.006344041,
0.010092941,
-0.023872683,
0.0055432734,
0.02216002,
-0.015230928,
0.015126338,
-0.011870972,
-0.021519406,
0.0030510882,
-0.002276468,
-0.012936483,
-0.016590599,
0.0027618313,
0.023127478,
0.002551017,
-0.021127192,
0.0031197255,
-0.03074948,
-0.016472936,
-0.011256506,
0.007870402,
0.02863153,
-0.004961491,
-0.0015198244,
-0.0024889167,
-0.0186824,
-0.0058341646,
-0.024029568,
-0.02936366,
-0.009217,
0.00068964076,
-0.032449067,
0.009694192,
-0.009288905,
0.023506617,
0.0042522396,
-0.005249114,
-0.010700871,
0.021885471,
0.01780646,
0.00687026,
0.009210463,
-0.008994745,
-0.011720624,
0.0097138025,
0.0029023744,
0.03127243,
-0.01108001,
-0.005608642,
0.03624046,
0.034750048,
-0.041757584,
-0.033834886,
0.007556632,
-0.00013890868,
0.043614056,
-0.015152485,
-0.045653563,
-0.029651282,
-0.0059681707,
0.0122435745,
-0.017008958,
-0.020238178,
0.002423548,
-0.013387528,
0.0026719493,
-0.008811713,
-0.0063407724,
0.05611257,
-0.030226529,
0.00636692,
-0.01095581,
-0.019754449,
-0.0032145102,
0.004601963,
-0.0075958534,
-0.04463381,
-0.01711355,
-0.024670182,
-0.015296297,
-0.0013106442,
0.004412393,
0.0068310387,
0.029415956,
0.031246282,
-0.003889443,
0.019479899,
0.012223964,
0.00839989,
-0.001108001,
0.00862868,
0.012498513,
-0.029729726,
0.021767806,
0.020447357,
-0.0039450065,
0.005458294,
-0.030252676,
0.015322444,
0.03365185,
-0.0047555794,
-0.018290188,
-0.0073670624,
-0.045287497,
0.020486578,
-0.012289332,
0.0017682258,
0.009354274,
-0.050752327,
-0.021297151,
-0.004546399,
0.0052229664,
0.004634647,
-0.028605383,
0.01367515,
-0.015740804,
0.0146164615,
-0.012603102,
-0.0058831912,
-0.0019741375,
-0.0122435745,
0.0005311214,
0.018290188,
0.02000285,
-0.0059224125,
0.00243989,
-0.0035952835,
0.00697485,
-0.01847322,
0.022774486,
-0.016093796,
-0.010923125,
0.01530937,
-0.008327984,
0.0027765394,
-0.00925622,
-0.00881825,
-0.012178206,
-0.0002265437,
0.010060256,
-0.021009529,
0.018002564,
-0.0133548435,
-0.004709821,
0.000535207,
-0.019048465,
0.000982166,
-0.030540299,
0.023284363,
0.013962774,
-0.003984228,
-0.02469633,
0.023585059,
0.020120513,
0.013139127,
0.018904654,
0.0035364516,
0.009589601,
-0.0021179488,
-0.014211175,
0.027141122,
-0.02348047,
-0.036763407,
0.045915037,
0.0128776515,
0.0035495253,
0.010060256,
0.0031033834,
-0.026186736,
0.006455168,
0.007236325,
-0.02104875,
0.0002549383,
-0.039456602,
0.006844112,
0.020251252,
-0.02031662,
0.0139497,
0.011936341,
-0.017754164,
-0.011701013,
-0.023114404,
0.008007676,
0.012060542,
0.0176365,
0.027245712,
-0.004098623,
-0.003055991,
-0.0043993196,
-0.0022127335,
0.011955951,
0.01652523,
-0.009380422,
0.043274138,
-0.009811855,
-0.003889443,
0.04188832,
0.0013531339,
-0.010465543,
0.0024300849,
-0.012367775,
-0.037207916,
-0.039744224,
-0.013492119,
0.018930802,
0.014825641,
-0.015832322,
0.020983381,
-0.019113835,
-0.007654685,
-0.015217855,
-0.004232629,
0.0022944445,
-0.030252676,
-0.023402026,
-0.03600513,
-0.0028647871,
-0.004173797,
0.010465543,
-0.024683256,
-0.011164989,
0.016616747,
-0.034070212,
0.017832605,
-0.0005311214,
0.024813993,
-0.006543416,
-0.0061185188,
-0.028893005,
-0.009321589,
0.003160581,
0.011406854,
-0.03859373,
-0.038201522,
-0.009681118,
0.017662646,
0.011217284,
-0.001435662,
0.040580943,
0.0065270737,
-0.008347594,
-0.010315195,
-0.019506047,
0.02452637,
-0.031220134,
0.004886317,
0.03305046,
-0.030723331,
-0.0030592594,
-0.001740444,
0.011910194,
0.007177493,
0.020695759,
0.004157455,
-0.0033959087,
0.011629107,
-0.020381989,
-0.019793669,
-0.009772634,
0.005644595,
-0.025899114,
0.0017077597,
-0.0020264324,
-0.026003705,
-0.016433714,
0.009811855,
-0.021976987,
-0.01635527,
-0.0078181075,
0.008641754,
0.017505761,
-0.00041815598,
-0.0049843704,
0.01506097,
-0.011341485,
0.026278254,
0.03030497,
-0.024160305,
-0.010001425,
0.008059972,
-0.05203356,
-0.012590029,
0.0009936056,
0.0100275725,
0.014459576,
-0.0047032842,
-0.0005674828,
0.019296866,
-0.009478475,
0.0055824947,
-0.0070532924,
-0.022251535,
0.012132447,
0.006612053,
0.019257646,
-0.0018139839,
-0.01221089,
-0.020042071,
0.0017339071,
0.0057328427,
-0.007164419,
0.008563312,
0.0009413106,
0.020264326,
0.008733271,
0.017008958,
-0.005615179,
-0.02268297,
-0.028579235,
-0.032056853,
0.012975705,
-0.005160866,
0.004909196,
-0.015570845,
-0.013054147,
-0.01200171,
0.013171812,
-0.007824644,
-0.019414531,
-0.0342271,
0.02010744,
-0.0186824,
-0.0060139284,
0.00015249313,
-0.012034394,
0.023676576,
0.004373172,
0.041417666,
0.0036900681,
-0.01095581,
0.01572773,
-0.015152485,
0.0032194129,
-0.001539435,
-0.019649858,
-0.009968741,
0.01426347,
-0.006837575,
0.010864293,
-0.00085633114,
-0.041391518,
-0.029180627,
0.038358405,
-0.022356126,
0.017492687,
0.008994745,
-0.008158025,
-0.030697184,
-0.007654685,
-0.016250681,
0.0059616338,
-0.0010761337,
-0.0062655983,
0.011799066,
-0.017231213,
-0.00028169862,
0.009583064,
-0.024513297,
-0.017453467,
0.019388383,
0.1809408,
-0.011746772,
-0.007072903,
0.020185882,
0.001353951,
-0.001160296,
0.022199241,
-0.0054942467,
-0.013302549,
0.016146092,
0.021506332,
0.008739808,
-0.0065205367,
-0.00091598014,
0.0033419793,
-0.019166129,
-0.026618171,
-0.009890297,
0.0041705286,
-0.018211745,
-0.008792102,
-0.00871366,
0.017270435,
-0.012707693,
0.02609522,
0.0076481486,
0.0042032134,
0.00088819844,
0.03767857,
-0.0057132323,
-0.012191279,
-0.0052164295,
-0.010164847,
0.003480888,
0.0157931,
-0.0012746914,
0.0010532546,
-0.009347737,
0.0000901885,
-0.008700586,
-0.009994888,
0.0002639265,
-0.035299145,
-0.01826404,
-0.018878506,
-0.0038142689,
-0.0056315213,
-0.020055145,
-0.018708548,
-0.0038175373,
-0.034044065,
-0.015074043,
-0.009596138,
0.020813422,
-0.022316905,
0.0054092673,
0.022343053,
0.010478617,
-0.010275974,
0.008641754,
0.019009244,
0.0043862457,
-0.026775056,
0.021976987,
-0.02873612,
0.030906364,
-0.024591738,
-0.03399177,
0.00039670683,
-0.01795027,
0.0133548435,
-0.016015353,
0.0101844575,
0.014564167,
0.00028680556,
-0.014877937,
0.013701298,
0.021336373,
0.007870402,
0.008243005,
-0.029860463,
-0.008243005,
-0.02337588,
0.009190852,
-0.011727161,
-0.029206775,
-0.0032145102,
0.011400317,
-0.037390947,
-0.013858183,
0.005644595,
-0.008811713,
-0.01795027,
0.0062884777,
0.033756442,
-0.01937531,
-0.013367917,
-0.006491121,
0.013367917,
-0.0016946859,
-0.019649858,
0.08623451,
-0.0065924423,
-0.0030543567,
-0.0017763969,
-0.006798354,
-0.032501362,
0.023271289,
0.008471795,
-0.009380422,
-0.013858183,
-0.044372335,
-0.007615464,
-0.009282368,
-0.009328126,
0.034357835,
0.026225958,
-0.033207346,
0.011785992,
-0.007726591,
-0.0040430594,
-0.0044221985,
0.019715227,
0.036658816,
0.012361238,
-0.0042849244,
-0.02651358,
-0.005615179,
-0.014538019,
-0.04452922,
0.01468183,
0.0034678143,
-0.014459576,
0.014119659,
0.01889158,
0.0067133745,
-0.0178849,
-0.00063693715,
0.0058472385,
0.021244857,
-0.0063178935,
-0.010282511,
0.008439111,
0.003994033,
0.016995884,
-0.024905508,
-0.0050235917,
-0.0005593117,
-0.019179203,
0.012302406,
-0.023192847,
0.006844112,
-0.0024791113,
0.0133548435,
0.006804891,
-0.014185027,
0.02727186,
-0.027533334,
-0.013282938,
0.0077527384,
-0.011249969,
0.03221374,
0.024931656,
-0.012576955,
0.010406711,
0.0017486152,
-0.1632651,
0.030932512,
0.00037852614,
-0.03365185,
0.018407851,
0.005428878,
0.025533048,
0.017388098,
-0.016185312,
-0.002982451,
0.02469633,
-0.004722895,
0.0070532924,
0.0017796654,
0.035717506,
-0.012701156,
0.000594856,
0.053863883,
0.011629107,
0.014524945,
0.029337512,
-0.013727446,
0.012289332,
-0.020787274,
0.018002564,
0.0061773504,
0.008360668,
0.009203926,
-0.015191707,
0.011406854,
-0.005690353,
0.002090167,
0.03916898,
0.004500641,
-0.00446142,
0.0032553656,
-0.009092798,
-0.014459576,
0.002735684,
0.0057949433,
0.036057424,
0.028160874,
0.017584205,
-0.013060684,
-0.022356126,
0.016773632,
0.0046934793,
-0.0415484,
0.023192847,
0.01374052,
0.0066578113,
0.010746629,
0.01436806,
0.010321732,
0.00008339628,
0.009347737,
-0.027402597,
0.016839,
-0.0072624725,
-0.020761129,
-0.0149956,
0.0017911048,
0.02253916,
0.010177921,
0.020748055,
-0.032815132,
-0.009674581,
-0.008458721,
-0.01962371,
0.025415385,
-0.010570133,
-0.020695759,
-0.010380564,
-0.0015737537,
0.028919153,
-0.005628253,
-0.026775056,
0.0157931,
-0.027088827,
-0.009726875,
-0.011642181,
0.0061152503,
-0.0025902383,
-0.042803485,
0.001717565,
0.0010851219,
0.00012511994,
0.0009805318,
-0.0015312639,
-0.014943305,
0.028553087,
-0.040136438,
-0.0038861746,
-0.016133018,
-0.0122435745,
0.019074613,
0.0014168685,
-0.021140266,
-0.011197674,
0.0029399614,
0.012478902,
-0.004729432,
-0.007556632,
-0.012681545,
0.033207346,
0.00019151013,
-0.012910336,
0.005674011,
0.031690788,
-0.011034252,
-0.0005397011,
0.000654505,
0.0036410417,
0.02588604,
-0.007929234,
0.015871542,
0.010400174,
-0.026448213,
0.00134578,
-0.034436278,
0.051353723,
0.008223394,
0.012825357,
0.039456602,
0.0011643816,
-0.0031327992,
-0.12006939,
0.004615037,
0.0032014365,
0.033494968,
0.017126624,
0.015466256,
-0.02278756,
0.014590314,
-0.002773271,
0.01635527,
0.0015737537,
-0.013727446,
-0.001599084,
-0.00062713184,
0.032135297,
0.013962774,
-0.02090494,
0.00057892234,
-0.048869707,
0.02904989,
-0.017231213,
-0.028657677,
-0.005755722,
-0.01363593,
-0.005144524,
0.003160581,
0.0015198244,
-0.0013653906,
0.010609355,
0.023506617,
0.016394492,
0.019636784,
-0.009177778,
-0.01212591,
-0.010217142,
-0.009694192,
0.04756233,
-0.03655423,
0.038829062,
-0.007713517,
0.016146092,
0.027925547,
0.035011522,
-0.022107724,
0.016917443,
-0.017375024,
-0.04262045,
0.018002564,
-0.015021748,
-0.008537164,
-0.013727446,
-0.012890725,
-0.03516841,
-0.014707978,
0.016146092,
-0.016891295,
0.009105872,
0.0005625801,
-0.018133303,
-0.010119089,
0.007550095,
0.012367775,
-0.011714087,
0.008850934,
0.01927072,
-0.047091678,
0.013001853,
-0.029128334,
0.018617032,
-0.011864435,
0.012871115,
0.01874777,
-0.02146711,
-0.0023924976,
-0.016159166,
0.016904369,
-0.016224533,
-0.0040136436,
0.031403165,
-0.021767806,
-0.005674011,
-0.00883786,
0.023611207,
-0.011746772,
-0.000007666788,
0.040973157,
0.013936626,
-0.00014973538,
-0.016146092,
-0.021937765,
0.0012281161,
0.040999305,
0.006706838,
-0.012773061,
0.001851571,
0.012413533,
-0.0035462568,
0.007360526,
0.026670467,
0.0064813155,
-0.012335091,
-0.012675009,
-0.039613485,
0.023676576,
-0.008792102,
0.0023303973,
-0.015492403,
-0.0139758475,
0.007131735,
0.000036846548,
0.008393353,
0.0160415,
-0.024617886,
0.021793954,
0.000073897376,
0.023127478,
-0.012217427,
0.020761129,
0.03302431,
0.02601678,
0.021127192,
0.01363593,
0.013544413,
0.033311937,
-0.0013841841,
0.0389075,
-0.014825641,
0.0016979544,
0.017139697,
0.03409636,
-0.02779481,
0.019597564,
0.027062679,
-0.047483888,
-0.009824929,
-0.0017682258,
-0.007857328,
-0.009112409,
-0.028893005,
0.0064192154,
0.0127207665,
0.009177778,
0.0042424346,
0.005435415,
-0.013178348,
-0.0067199115,
-0.0063636517,
-0.005307946,
-0.04348332,
0.016551377,
0.0069290916,
-0.01795027,
0.018342482,
0.01857781,
-0.012975705,
-0.028370054,
-0.03937816,
0.008079583,
0.016146092,
-0.0071121245,
0.0066904956,
-0.043326434,
0.013871257,
0.008491406,
-0.012335091,
0.0032194129,
-0.017767237,
-0.020081293,
0.0114591485,
0.005660937,
0.026539728,
-0.017322728,
-0.042646598,
-0.0018499368,
-0.005520394,
0.0005372497,
-0.005288335,
0.0054484885,
-0.010360953,
0.015126338,
-0.008589459,
-0.0001571915,
0.0077919597,
-0.0058766543,
-0.014354986,
0.012616176,
0.018786991,
-0.0030739673,
-0.013086832,
0.0073801363,
-0.0057459166,
0.014877937,
-0.019244572,
0.0138189625,
0.0025673592,
0.012223964,
0.01325679,
0.0043666353,
-0.013923552,
-0.0031131885,
0.0013743788,
0.008053435,
-0.016054574,
0.018669326,
-0.03061874,
-0.020042071,
0.008935913,
0.007138272,
-0.008857471,
-0.027298007,
-0.02285293,
-0.004938612,
0.03451472,
0.016655969,
0.008707123,
-0.002565725,
-0.00032561828,
0.013178348,
-0.028265465,
0.008256078,
-0.0017388099,
0.025663787,
0.0028124922,
0.01851244,
0.0041247704,
0.022133872,
0.0059910496,
-0.00007154818,
0.030043496,
-0.012962631,
0.025389237,
-0.007890013,
0.0052098925,
0.0074716527,
-0.034174804,
0.0028190291,
-0.005353704,
-0.036815703,
0.027716367,
0.009334663,
-0.019100761,
0.06149896,
-0.004683674,
-0.023715798,
-0.013465971,
-0.00085633114,
0.022329979,
-0.00385349,
-0.0046804054,
0.002461135,
-0.0055890316,
0.011870972,
-0.025284648,
0.0021130461,
-0.060034696,
-0.009916445,
0.012008247,
0.010426322,
0.008484869,
0.015296297,
-0.013805889,
-0.004834022,
-0.011805603,
0.00913202,
0.018081008,
-0.028553087,
-0.014119659,
0.043953974,
-0.023611207,
-0.00802075,
-0.006572832,
-0.021976987,
0.016067648,
-0.035848245,
-0.0029546693,
0.015296297,
-0.0004432821,
-0.016930517,
-0.008484869,
0.0055301995,
-0.008870545,
-0.014564167,
0.040554795,
-0.0106616495,
-0.028814562,
-0.024487149,
-0.00041325332,
-0.0011464051,
-0.0028321028,
-0.026134443
] |
CONTEXT Adequate vitamin D status for optimum bone health has received increased recognition in recent years; however, the ideal intake is not known. Serum 25-hydroxyvitamin D is the generally accepted indicator of vitamin D status, but no universal reference level has been reached. OBJECTIVE To investigate the relative importance of high calcium intake and serum 25-hydroxyvitamin D for calcium homeostasis, as determined by serum intact parathyroid hormone (PTH). DESIGN, SETTING, AND PARTICIPANTS Cross-sectional study of 2310 healthy Icelandic adults who were divided equally into 3 age groups (30-45 years, | [
0.007845884,
-0.02205851,
0.012643449,
-0.04046418,
-0.01783974,
0.026573109,
-0.013325141,
-0.029377047,
-0.0051898593,
-0.012424793,
0.014058281,
0.008559731,
-0.013543796,
0.003000086,
-0.036502652,
-0.0033473629,
0.052683182,
-0.02652166,
0.018740086,
0.004221986,
-0.019563261,
-0.0077622803,
0.0068297777,
0.004151244,
0.0062606293,
0.0010932789,
0.006234905,
-0.030869052,
0.007582211,
-0.03465051,
0.032978438,
-0.004437426,
-0.017209496,
0.0018505353,
0.018920155,
0.0065661045,
-0.023794893,
-0.030508913,
0.012534121,
-0.013325141,
-0.011633773,
-0.00971732,
0.008090264,
-0.018958742,
0.008064539,
0.0059969565,
0.015511698,
-0.014817145,
-0.036656998,
0.037814587,
0.007132037,
0.014006832,
-0.017003702,
-0.001282191,
-0.0037107172,
0.0018296344,
0.0061287927,
0.024695242,
-0.007485745,
-0.030406015,
-0.011518015,
-0.0025595587,
-0.008900576,
0.010270391,
-0.019576123,
-0.0097752,
-0.00090195506,
0.01906164,
0.013479486,
0.024952482,
0.025171138,
0.038534865,
-0.015035801,
0.023846341,
0.030071601,
0.0023778817,
-0.010308977,
-0.019331744,
-0.00071022933,
-0.00255152,
0.019203123,
-0.025672762,
-0.009524388,
0.022920271,
0.010334701,
0.014251212,
-0.0013175618,
0.03279837,
0.0056914813,
-0.019794779,
0.0017637161,
0.0017138754,
0.016785046,
0.016270563,
-0.02945422,
0.027627802,
0.0326183,
0.026676005,
-0.018958742,
-0.010128908,
-0.016514942,
-0.01826419,
-0.020334987,
-0.016489219,
-0.02511969,
-0.0076400903,
-0.023859205,
-0.004649651,
0.014315522,
-0.022958856,
-0.01912595,
0.056747604,
0.0008042835,
-0.038972177,
0.022663029,
0.009582268,
-0.011852429,
0.013801038,
-0.018920155,
0.00941506,
0.018958742,
-0.00947294,
0.013981108,
0.0070548644,
0.03197519,
0.0018296344,
-0.008977749,
-0.019074501,
-0.007106313,
0.012315465,
-0.0053667133,
-0.0049969275,
0.007781573,
0.017531049,
-0.033467196,
0.006392466,
-0.012990726,
-0.02542838,
0.0059680166,
-0.028425252,
-0.000393701,
0.013100053,
-0.016039044,
-0.013183657,
-0.0091642495,
0.001214665,
0.016913667,
0.022997443,
-0.018135568,
-0.009453647,
-0.015666043,
-0.006151302,
0.031023396,
0.01699084,
-0.0101674935,
-0.011608049,
0.0048232893,
0.024669517,
-0.005797594,
-0.013878211,
0.0061995345,
-0.024296517,
-0.0103282705,
-0.0011487467,
0.0073828483,
0.012083948,
0.025261173,
-0.002469524,
-0.0064310525,
-0.012971433,
-0.0033505782,
0.028425252,
-0.038226176,
0.00473647,
-0.0028795036,
0.008341075,
-0.016836494,
0.0075757797,
-0.012026068,
-0.010726995,
-0.019267432,
0.02248296,
0.028631045,
0.022495821,
-0.0039647436,
0.022753064,
0.03606534,
0.0070548644,
0.0033023453,
-0.02052792,
0.0058683353,
-0.009968131,
-0.021183886,
-0.01834136,
-0.6466037,
0.0076786764,
-0.0007098274,
-0.0006933478,
0.03673417,
0.028193733,
0.0002301111,
-0.001255663,
-0.0035885272,
0.015743216,
-0.01301645,
0.016977979,
-0.023640549,
-0.020180643,
-0.009048491,
-0.031074844,
-0.011691653,
-0.044091295,
0.019164536,
-0.017878326,
-0.019460365,
0.016772185,
-0.0053442046,
0.03508782,
0.020257816,
0.014457006,
0.01319652,
0.007492176,
0.0063635265,
0.048618756,
-0.011260773,
0.026045762,
0.024759552,
0.04162177,
0.042676464,
-0.017878326,
-0.0011849214,
0.012437656,
-0.01723522,
0.039872523,
-0.02914553,
-0.006167379,
0.029402772,
0.008720507,
-0.03074043,
0.020322125,
0.011292928,
0.0029888316,
0.02963429,
-0.017672531,
0.014997214,
-0.012399069,
-0.0055049807,
-0.025685623,
0.0044406415,
-0.021672646,
0.0051094713,
-0.043731157,
0.015022938,
0.008141712,
-0.007607935,
0.031872295,
-0.00087783864,
-0.0031463923,
-0.0134151755,
0.02670173,
-0.0059229992,
0.02500393,
0.0021527947,
-0.0003699865,
0.012965001,
0.028579596,
0.014315522,
0.0066882945,
0.031923745,
-0.019936262,
0.03277264,
0.0026431626,
-0.011710946,
0.02590428,
0.0055692913,
0.004241279,
-0.0048650913,
0.0046785907,
0.032232434,
-0.0034534752,
-0.04007832,
0.009485803,
0.015743216,
0.004533892,
0.03359582,
-0.008997043,
-0.0012508397,
-0.036502652,
0.00081272423,
0.017711118,
-0.0001750452,
-0.006472854,
-0.00017122677,
-0.0284767,
-0.032361057,
0.0134409,
-0.030174498,
0.023576237,
0.036091067,
0.002654417,
-0.019074501,
-0.003046711,
0.0349592,
-0.039075073,
0.0020338204,
0.004119089,
-0.013633831,
0.016399184,
0.020167781,
-0.019357467,
0.009157819,
-0.00819316,
-0.01974333,
0.0036914242,
0.037120033,
0.0035370789,
0.033055607,
0.012321896,
0.00064350717,
0.027524903,
-0.0009517957,
-0.0011109643,
-0.0058201025,
-0.013074329,
-0.011280065,
0.024347965,
0.02701042,
-0.018187016,
0.020553643,
0.007350693,
0.027627802,
0.004717177,
-0.00045419307,
-0.03606534,
-0.009762337,
-0.03398168,
-0.007993798,
-0.020759437,
-0.003623898,
-0.016900806,
-0.024399413,
0.013878211,
0.011858861,
0.017916912,
-0.021428267,
-0.024206482,
-0.025968589,
0.021724096,
-0.031743675,
-0.014045418,
-0.006887657,
-0.0028457406,
0.007955212,
-0.0066754324,
0.008572592,
0.01081703,
-0.022534408,
-0.016913667,
-0.008360368,
-0.022174269,
-0.0075050383,
0.018842984,
0.0047943494,
-0.036656998,
0.0057622227,
0.021286784,
-0.013659555,
0.00464322,
-0.009820217,
0.011775257,
-0.009524388,
-0.0065114405,
-0.0022026354,
-0.025158277,
-0.007099882,
-0.014071142,
-0.027396282,
-0.0070677265,
0.031049121,
-0.0050322986,
0.004572478,
0.01191674,
0.008521144,
0.03279837,
0.021595474,
-0.00044896785,
-0.010714133,
0.013698141,
0.0071770544,
-0.0454804,
0.00050604343,
-0.004138382,
0.012617725,
-0.0018103413,
0.02365341,
0.002028997,
0.038972177,
-0.015923286,
0.034830578,
0.00025282076,
-0.0087398,
0.013955384,
0.021672646,
0.005321696,
0.0026753177,
-0.016103355,
0.004041916,
-0.015640318,
-0.02205851,
0.016720736,
-0.0111836,
-0.0053152647,
-0.015190146,
-0.016167665,
0.0041351668,
-0.017312393,
0.040335562,
0.002646378,
-0.0008247825,
0.006739743,
0.014508454,
-0.002252476,
0.0022299674,
0.02052792,
-0.018624328,
-0.025827106,
-0.019074501,
-0.01783974,
0.017196635,
-0.006177026,
0.009003473,
-0.022097096,
-0.012855673,
0.006392466,
0.018161291,
0.024862448,
0.027602077,
-0.009968131,
0.014019694,
-0.029299874,
0.01374959,
-0.003488846,
-0.005308834,
0.01931888,
0.028219458,
0.0058811973,
-0.0100581655,
0.011717377,
-0.0009276793,
0.014315522,
0.0015346098,
0.011633773,
0.0050258674,
0.019833365,
0.04007832,
0.02719049,
0.0158847,
-0.009678734,
0.008752663,
0.017878326,
-0.008662627,
-0.008096695,
-0.0045756935,
-0.020952368,
-0.03673417,
-0.01448273,
0.016785046,
-0.0118459985,
0.014315522,
0.0029068356,
0.029737186,
0.010353995,
0.0021222474,
0.013891073,
-0.020026296,
-0.036399756,
-0.00537636,
0.02310034,
-0.0030660043,
-0.008392523,
-0.012817088,
-0.0030386723,
0.0026077917,
-0.0018360654,
-0.003684993,
-0.0284767,
0.0024647007,
-0.0012387815,
-0.011582325,
-0.0033023453,
0.0082188845,
-0.008353937,
0.008122419,
0.011054979,
0.0071770544,
-0.018791534,
-0.0052638166,
-0.009974563,
0.023859205,
-0.009054922,
-0.021119576,
-0.009395767,
0.010791305,
0.0015225516,
0.0008673882,
-0.00021503831,
-0.0054728254,
-0.0227402,
0.01399397,
0.0063603106,
0.0061384393,
0.019215984,
0.03922942,
-0.017183771,
-0.0048747375,
-0.032721195,
-0.020270677,
-0.020579368,
0.034676235,
0.0013995578,
0.016116217,
0.0057493607,
0.0072735203,
0.0008794464,
-0.00030507304,
-0.019846227,
0.010579081,
0.012456948,
0.014302661,
0.0036464066,
0.00084648724,
0.012238293,
0.0027653526,
0.021029541,
0.013518072,
-0.0047139614,
-0.009704458,
-0.012508397,
-0.030483188,
0.00045298724,
0.029479943,
0.03634831,
0.046535093,
-0.007980936,
0.011897447,
0.033107057,
0.007781573,
-0.012244724,
-0.020553643,
0.024669517,
-0.009067784,
-0.0036753465,
-0.026676005,
-0.014868593,
-0.030714706,
0.015112973,
0.012971433,
0.013029312,
0.015305905,
0.0077365558,
0.008115988,
0.0077108317,
-0.00052614044,
0.001146335,
0.0040483475,
0.021029541,
-0.0065661045,
-0.004479228,
0.018958742,
0.0063828193,
0.008296058,
-0.017068014,
-0.01656639,
-0.004540323,
0.0141740395,
-0.018444259,
-0.00039993107,
-0.016849358,
-0.012411931,
-0.012881398,
0.025801381,
-0.0013175618,
0.0001893141,
-0.008720507,
-0.026444487,
-0.015061525,
0.02176268,
0.023267547,
0.008090264,
-0.012553414,
-0.011865292,
0.011016393,
0.012103241,
-0.011717377,
0.014148315,
-0.0054631787,
0.018791534,
-0.0017074444,
-0.028605321,
0.0017379919,
-0.023679135,
-0.0019984494,
-0.0070741577,
0.01607763,
-0.0075500556,
-0.01863719,
0.0040740715,
0.001717091,
0.00047388818,
0.0154731115,
-0.009897389,
0.0037557345,
-0.0088941455,
-0.0049165394,
0.0036560532,
0.005537136,
0.011704516,
-0.012817088,
0.00034486517,
-0.01638632,
-0.013286554,
-0.024720965,
0.017621083,
0.0111836,
-0.023743445,
0.01601332,
-0.00065596733,
-0.046612266,
0.018907294,
0.004180184,
-0.007132037,
-0.0026721023,
0.020283539,
0.011955326,
-0.002475955,
-0.0055146273,
0.023563376,
-0.002734805,
0.0040001147,
-0.007614366,
0.03629686,
-0.025647037,
-0.03807183,
0.006977692,
0.011942464,
-0.02353765,
-0.016759323,
-0.01081703,
0.018727224,
0.00093009096,
-0.01796836,
-0.016772185,
-0.023897791,
0.0068490705,
-0.014366971,
-0.008720507,
-0.012501965,
-0.023666272,
-0.0022830237,
-0.009492233,
-0.014598489,
-0.017312393,
0.010849185,
-0.03277264,
0.0038779245,
-0.021183886,
0.005910137,
0.01876581,
-0.0013207773,
-0.018019808,
-0.03668272,
0.009588699,
0.011633773,
-0.024463722,
-0.016643563,
0.00062220433,
0.018907294,
0.0076915384,
0.025582727,
-0.013338002,
-0.009569406,
0.00082960573,
-0.0038618469,
-0.0038682779,
0.002265338,
-0.0011439234,
-0.030148773,
0.0024261144,
0.02041216,
-0.009537251,
0.011344376,
0.005852258,
0.0187015,
0.025081104,
-0.0076786764,
-0.018560017,
-0.018971605,
-0.030663257,
-0.0030386723,
-0.0073957103,
-0.0040194076,
0.0047718408,
-0.00034325742,
-0.0076015037,
0.04993069,
0.024206482,
0.008450403,
-0.018585742,
0.0038907866,
-0.027936492,
0.015305905,
0.0017412074,
-0.0011720593,
-0.019280296,
-0.005524274,
0.007871608,
0.007755849,
0.027087592,
0.015743216,
0.030380292,
0.019228846,
0.007099882,
-0.008064539,
0.024733827,
-0.0057847314,
-0.0099617,
-0.0110871345,
-0.016039044,
-0.025981452,
0.012604862,
-0.02010347,
-0.006160948,
-0.0025434813,
0.022701615,
-0.01069484,
0.020244952,
0.0014606528,
-0.021402542,
-0.00036395737,
-0.026135797,
0.017749704,
-0.025184002,
0.046766613,
0.02927415,
0.014894317,
-0.02554414,
0.0051673506,
0.0015908816,
-0.0052734627,
0.026856074,
0.008302488,
-0.0139296595,
-0.020373574,
0.0021077774,
0.019267432,
-0.017646808,
-0.024103584,
0.023756307,
0.0017186988,
0.0039325887,
-0.0015715885,
0.020180643,
-0.0108427545,
0.00953082,
0.0056914813,
-0.017119462,
0.0042573567,
-0.0057172053,
-0.011273635,
0.040669974,
-0.031306364,
0.024039274,
0.0047589787,
-0.0023762737,
-0.013556658,
-0.03519072,
-0.026778903,
0.025968589,
-0.0015458642,
0.01783974,
-0.016707875,
0.0162577,
-0.002387528,
-0.0039679594,
0.0127399145,
0.0008223708,
-0.030020153,
0.028708218,
-0.004717177,
-0.007035571,
0.04241922,
-0.0036367602,
0.002001665,
-0.019781917,
-0.00217048,
0.004437426,
-0.042444944,
0.0086497655,
0.02511969,
0.018482845,
-0.019035915,
0.002538658,
-0.012656311,
0.0065918285,
-0.019074501,
-0.009601561,
-0.010566219,
-0.004260572,
-0.014045418,
-0.013530934,
-0.0030965516,
-0.001500043,
0.0001160604,
0.009968131,
-0.009730183,
-0.0032878756,
-0.030560361,
0.04380833,
0.024476586,
0.03598817,
-0.027885042,
-0.014855731,
-0.0406957,
-0.029737186,
0.022392925,
0.005305618,
-0.04234205,
-0.019087363,
0.005659326,
0.03135781,
0.006302431,
-0.004588556,
0.029016908,
-0.002869857,
0.017492462,
0.011955326,
0.0012781717,
0.013620969,
-0.0068426398,
0.0047010994,
-0.017814014,
-0.00095018797,
0.00079302915,
-0.0046914527,
0.01271419,
-0.029788634,
-0.02780787,
0.00812885,
-0.028450975,
0.03313278,
-0.01827705,
-0.016785046,
-0.032541126,
0.0071963477,
-0.025659898,
0.014508454,
-0.006649708,
-0.025184002,
0.009633716,
-0.0036978552,
0.023910653,
-0.000014105609,
-0.004038701,
-0.0005317676,
-0.0037332259,
-0.027782146,
-0.01106141,
0.0014895925,
-0.013428037,
0.018508568,
0.02070799,
-0.011936033,
0.008070971,
-0.008778387,
-0.038895003,
-0.020630816,
0.015730355,
-0.009016335,
0.02132537,
0.0072606583,
0.006752605,
0.033055607,
-0.007607935,
0.008488989,
-0.020733712,
-0.031615052,
0.0149586275,
0.006623984,
0.0405928,
0.018495707,
-0.023756307,
0.0032830522,
0.01656639,
-0.0047525475,
-0.008366799,
0.032361057,
0.017621083,
0.023190375,
-0.01772398,
0.028245183,
0.010559788,
-0.01699084,
0.009299302,
-0.027216213,
-0.0019791564,
-0.007845884,
-0.021826992,
0.001364187,
-0.01216112,
-0.0050419453,
0.001995234,
-0.0045113834,
-0.014058281,
-0.012354052,
-0.0007910194,
-0.010154632,
0.009479371,
0.037197206,
-0.0056818346,
0.009537251,
0.014739972,
0.008939163,
0.021093851,
0.020116331,
-0.016141942,
0.0027508826,
-0.006122362,
-0.0054471013,
-0.011273635,
-0.007768711,
0.017273806,
-0.02749918,
0.011382963,
-0.011691653,
-0.01228331,
-0.03519072,
0.030277394,
0.010399012,
0.010746288,
0.013125778,
-0.01674646,
0.012682036,
-0.0013352472,
0.0032862676,
-0.025402656,
-0.02505538,
-0.015614595,
0.014212626,
-0.008939163,
0.0042637875,
0.0035820962,
-0.014058281,
-0.012212568,
-0.0072156405,
0.17821732,
0.006623984,
0.013479486,
0.0309205,
0.024888173,
0.018778672,
0.01686222,
0.0080002295,
0.0078909015,
0.010714133,
0.028631045,
0.020605091,
-0.016051907,
0.0024647007,
0.011035685,
-0.04051563,
-0.0068297777,
-0.010746288,
0.002564382,
-0.020849472,
0.0013722258,
-0.012418362,
0.00032195455,
-0.0072220718,
0.0382519,
0.0154731115,
-0.007415003,
0.0007950388,
0.018482845,
0.0011005139,
-0.0075886417,
-0.020798024,
-0.008347506,
0.025389794,
-0.020399299,
-0.0021270704,
-0.004797565,
-0.02511969,
-0.0058811973,
0.014611351,
-0.010862048,
0.001839281,
-0.03922942,
-0.0109971,
0.028065111,
-0.00473647,
0.010212511,
-0.02003916,
-0.018006947,
0.03184657,
-0.035345063,
0.0004674571,
0.016900806,
0.008778387,
-0.013672417,
-0.00089472014,
0.02719049,
0.0013063075,
-0.020013435,
0.014431281,
0.005646464,
0.0017347764,
0.0030643963,
0.051165454,
-0.022135682,
0.0121161025,
-0.0227402,
-0.009466509,
-0.019228846,
-0.015357353,
0.026573109,
-0.0010056559,
-0.0124955345,
0.025042517,
-0.0053506354,
-0.013865349,
0.022174269,
0.008656196,
-0.013595245,
-0.0030579653,
-0.02297172,
-0.009897389,
-0.00026909934,
0.014405557,
-0.022920271,
-0.02719049,
0.009537251,
0.00018911314,
-0.00058602967,
-0.010559788,
0.013209381,
-0.027267663,
0.006196319,
0.019344606,
0.0027026497,
-0.0015072778,
-0.018933019,
0.008720507,
-0.016527804,
-0.0047332547,
-0.009511527,
0.07120461,
-0.003961528,
0.025930002,
-0.026573109,
-0.013813901,
-0.026727453,
0.025402656,
-0.000082146646,
-0.0018087334,
0.015100111,
-0.04290798,
0.020244952,
-0.010399012,
0.00018479227,
0.014572765,
-0.0030370646,
-0.025659898,
-0.005974448,
-0.015858974,
-0.0030852973,
-0.029917255,
0.0027331973,
0.027473455,
-0.014855731,
-0.014161177,
-0.015228732,
0.004723608,
-0.0029084433,
-0.03282409,
-0.012366913,
-0.024540896,
-0.0019984494,
0.017299531,
-0.00412552,
0.018598603,
0.0044438574,
-0.011453704,
0.0055210586,
0.009698027,
-0.0018859061,
-0.031692225,
0.023254685,
0.013981108,
0.014328385,
-0.032283884,
0.010128908,
-0.009878096,
0.0006161752,
-0.0035210012,
-0.032232434,
0.006630415,
-0.015408802,
-0.035473686,
0.01148586,
-0.0028312707,
-0.007582211,
-0.034367543,
0.002353765,
0.0073378305,
0.014830006,
0.0038425538,
0.020849472,
-0.008225316,
-0.013428037,
0.010579081,
-0.1596959,
0.0139296595,
0.039743904,
-0.043551087,
0.017209496,
-0.0026093994,
0.03838052,
0.027627802,
-0.010482615,
-0.00013354482,
0.028528148,
0.010958513,
-0.03282409,
-0.02505538,
-0.009665872,
-0.0075050383,
0.0028666416,
0.010797737,
0.009537251,
0.01705515,
0.024669517,
0.004820074,
0.012173982,
-0.007415003,
0.034933478,
0.013286554,
0.0053956527,
0.014302661,
0.022277165,
0.006257414,
0.0035949582,
0.010489047,
0.013865349,
0.0019904107,
-0.0041769687,
-0.027216213,
0.0024309377,
-0.0037171482,
0.0055950154,
0.015331629,
0.013942521,
-0.0036142515,
0.011942464,
0.00095983455,
0.004099796,
0.03416175,
-0.009376475,
-0.01687508,
0.023318997,
-0.038277622,
0.022444373,
-0.025647037,
0.025557002,
0.01839281,
-0.010585512,
0.011299359,
-0.027344834,
0.022328613,
0.010386149,
-0.002028997,
-0.0026431626,
-0.012887829,
0.0062960004,
-0.015151559,
0.008849128,
-0.0066625704,
-0.006778329,
-0.005823318,
-0.014637075,
0.0049872813,
-0.016707875,
-0.03182085,
-0.009479371,
0.00305475,
0.0056239553,
0.009292871,
-0.02554414,
-0.023601962,
-0.020772299,
0.008945594,
0.003929373,
-0.011807412,
-0.04926186,
-0.03025167,
-0.042625014,
0.012604862,
0.019563261,
0.028579596,
-0.00510304,
-0.0017299531,
0.004791134,
-0.035422236,
-0.0037975365,
-0.013402313,
0.011865292,
0.017994085,
0.008900576,
0.0052155834,
-0.009325026,
0.0015651573,
0.025312621,
-0.010514771,
-0.006855502,
0.0113701,
0.010900633,
-0.015100111,
0.0066046906,
-0.012315465,
0.02090092,
0.0010426344,
0.0074342964,
-0.00079021556,
0.0040226234,
-0.0026045763,
-0.024335101,
0.031074844,
-0.024823861,
-0.0075050383,
0.021286784,
-0.028219458,
0.038895003,
0.012643449,
-0.018251326,
0.024309378,
-0.0035467253,
-0.025132552,
-0.12162406,
0.00843754,
0.02578852,
0.027936492,
0.013698141,
0.010701271,
-0.0005016221,
-0.0010530849,
-0.017621083,
0.0051351953,
-0.0149586275,
-0.027061868,
-0.022701615,
-0.007228503,
0.039872523,
-0.0050451607,
-0.000875427,
-0.03202664,
-0.026830351,
0.014418419,
0.019833365,
-0.012450517,
0.014135453,
-0.004533892,
-0.020849472,
-0.007755849,
-0.01448273,
0.0053795753,
0.009189974,
0.009878096,
-0.00063144893,
0.020888058,
0.01039258,
-0.035396513,
-0.025891416,
0.0034534752,
-0.009099939,
-0.0066754324,
0.03135781,
0.011569463,
0.0152030075,
0.018405672,
0.017531049,
-0.0039325887,
0.013363726,
0.006424621,
-0.04180184,
-0.010289684,
0.0036335445,
0.00531848,
-0.02310034,
0.008669059,
-0.0365541,
0.002734805,
0.0013191696,
-0.003149608,
0.00019624758,
-0.023627685,
0.014469868,
0.018778672,
-0.01686222,
0.0342132,
-0.017929774,
0.012913553,
0.017029427,
-0.017492462,
-0.0086497655,
-0.034136027,
0.004852229,
-0.0013135425,
-0.005604662,
0.010051735,
0.011331514,
-0.0072863824,
-0.023087477,
0.018688638,
-0.01637346,
0.0023023167,
-0.011029255,
-0.0069069504,
-0.0030354566,
-0.0078394525,
-0.0008034796,
0.0041994774,
-0.0011543739,
-0.005414946,
0.008643335,
0.0020868764,
0.013852486,
-0.025106829,
-0.015421663,
0.029299874,
0.03519072,
0.00015957048,
-0.0004296747,
0.003136746,
0.016514942,
-0.0130100185,
0.026290141,
0.00632494,
-0.03629686,
-0.022765925,
-0.042136256,
0.029248426,
0.02041216,
-0.027833594,
-0.0058458266,
-0.046252128,
-0.009215698,
-0.00485866,
0.011987481,
0.003244466,
-0.010276821,
0.018367086,
-0.024309378,
0.013132209,
-0.014457006,
-0.016360598,
0.016707875,
0.004913324,
0.007254227,
0.040104043,
-0.001811949,
0.006791191,
0.020656541,
0.016463494,
-0.006926243,
-0.0017990869,
0.0053827907,
-0.0000057182356,
-0.013492348,
-0.019949125,
0.025685623,
-0.04771841,
-0.0052059367,
0.018842984,
-0.004450288,
-0.0025466967,
-0.0158847,
0.025209725,
0.022907408,
0.010862048,
-0.004897246,
-0.03935804,
0.017145185,
-0.016540667,
0.0032894833,
0.010630529,
-0.047564063,
-0.009974563,
-0.005633602,
-0.024618069,
0.006141655,
0.012643449,
0.018688638,
-0.012675604,
-0.021981336,
0.01173024,
-0.012392638,
0.017608222,
0.00053297344,
-0.009479371,
0.0021817344,
-0.0061995345,
-0.0027331973,
-0.008392523,
0.0083796615,
-0.014997214,
-0.012836381,
0.012585569,
0.0046978835,
-0.0032701902,
-0.019588985,
0.01980764,
0.0016326834,
0.005077316,
0.012399069,
0.005456748,
-0.011833136,
0.009434354,
0.0031592546,
0.012746346,
0.008032384,
0.017826878,
-0.010849185,
0.04468295,
0.05402084,
0.016849358,
-0.0076915384,
0.029042633,
-0.0053313426,
0.010887772,
0.0012403892,
0.011054979,
0.0055853687,
-0.0067268806,
-0.002871465,
0.015151559,
-0.019524675,
0.0064374832,
-0.011505153,
0.008771955,
-0.024129309,
-0.0011431195,
0.013067898,
-0.024103584,
-0.011743101,
-0.00095340353,
-0.028219458,
-0.03295271,
-0.029814359,
0.000037104157,
0.002157618,
0.014611351,
0.032232434,
0.01130579,
0.024849586,
-0.0020724067,
0.009755907,
0.019293157,
-0.0037911055,
0.021261059,
0.0022508684,
0.035216443,
0.0041962615,
-0.0067268806,
0.010778444,
0.0053538512,
0.006234905,
-0.0038457692,
0.03164078,
0.0049165394,
-0.01668215,
-0.015112973,
-0.0018569664,
-0.004070856,
0.00094375695,
-0.03935804,
0.008643335,
0.02798794,
-0.007003416,
0.063898936,
-0.018289912,
-0.019023053,
-0.007132037,
-0.0019598631,
0.0075693484,
-0.00078981364,
0.018225603,
-0.028991183,
-0.010038872,
-0.00070138666,
-0.02310034,
0.026418762,
-0.02976291,
-0.0033634403,
0.016900806,
0.013620969,
-0.002490425,
-0.0044695814,
-0.0053120493,
0.0041287355,
-0.011196462,
0.002734805,
0.008598317,
-0.022354338,
-0.020849472,
0.03526789,
0.011569463,
-0.0070420024,
-0.04620068,
0.0030708276,
0.012321896,
-0.027550628,
0.0035210012,
0.01980764,
-0.011447273,
-0.018096982,
-0.014868593,
-0.011653067,
-0.007968074,
-0.023807757,
0.03588527,
-0.020129194,
0.0018537508,
-0.044580054,
-0.028759666,
-0.015293042,
-0.016463494,
0.0024036057
] |
Sex differences in longevity and aging are seen throughout the animal kingdom. These are likely to result, in part, from sex differences in endocrinology. In the nematode Caenorhabditis elegans, males are the longer-lived sex. Here we explore the possibility that sex differences in insulin/insulin-like growth factor 1 (IGF-1) and steroid endocrinology contribute to this sex difference in aging by studying C. elegans populations in liquid culture. We report that in hermaphrodite populations, mutational loss of the DAF-12 steroid receptor affected life span as in previous plate-culture | [
-0.0008980929,
-0.018420035,
0.00354921,
-0.024648583,
0.008858085,
0.00075781776,
-0.016813096,
0.019309828,
-0.026016474,
-0.03460895,
0.0098342,
0.019588718,
0.014581975,
0.015710816,
-0.02046523,
0.013174242,
0.05269697,
0.020425389,
0.0048174965,
-0.0017696249,
-0.0054483195,
0.014156999,
0.012158286,
-0.0010035068,
-0.0013164282,
0.007470274,
-0.006490838,
-0.03739785,
0.00095619506,
-0.0019406112,
0.000036780722,
-0.0032852604,
-0.02563134,
-0.020119937,
0.0009113734,
0.0013554397,
0.01638812,
-0.012649664,
0.014661658,
-0.026919546,
0.009747877,
0.012251249,
-0.0120122,
-0.006404515,
-0.005537963,
0.029270193,
-0.0136124985,
-0.019150462,
-0.0035126887,
-0.0025714342,
0.0028768855,
0.0053155147,
-0.018911414,
-0.006650204,
-0.018220827,
-0.010524786,
0.017344316,
0.007124981,
0.013048078,
0.009734597,
-0.014077316,
0.010989603,
-0.018220827,
0.011700109,
-0.036999434,
-0.00272914,
-0.0059662587,
0.003924384,
0.011434499,
0.01634828,
0.03960241,
0.028260875,
-0.016759975,
0.0023224251,
0.0127625475,
-0.011693468,
-0.03211222,
0.017862255,
0.032324705,
0.00068975525,
0.026547693,
-0.028818656,
-0.013406651,
0.004040588,
0.00764292,
0.0030063703,
-0.018805169,
0.024183767,
0.023267413,
-0.010896639,
0.005302234,
-0.0070320177,
0.0338918,
0.0365479,
0.012410615,
-0.0042729964,
-0.011182169,
0.011573944,
-0.02455562,
-0.01634828,
-0.016534206,
-0.0029980699,
0.027331242,
-0.019349668,
-0.012503578,
0.0078022857,
-0.0016002987,
-0.006198667,
0.02017306,
-0.01965512,
0.0035824112,
0.024050962,
0.009767798,
-0.032138776,
-0.005863335,
-0.007317548,
0.01665373,
0.0064011947,
-0.021886243,
0.0033931644,
0.015511609,
0.0056707677,
0.023134608,
-0.017131828,
0.021301901,
0.025551656,
-0.0025448732,
0.0052557527,
-0.017370876,
-0.014210121,
0.00928306,
-0.021115974,
0.0072976276,
0.013599219,
-0.024582181,
0.0038911826,
-0.024183767,
-0.020983169,
0.01778257,
-0.027437486,
-0.006029341,
0.028792094,
-0.03463551,
0.003356643,
-0.02154095,
0.009953725,
0.018698925,
0.00709842,
0.009568591,
0.024329852,
0.0030960136,
-0.008811603,
0.028765535,
-0.020558193,
0.013758584,
0.023891596,
-0.0009146935,
0.016587328,
0.00068103994,
-0.009542029,
-0.0038347405,
0.0059894994,
0.009030731,
-0.0031009936,
-0.0021746797,
0.026773462,
0.007038658,
0.0012168246,
0.011142328,
0.0064277556,
-0.015989706,
0.026082875,
-0.012576621,
0.043320946,
-0.012204767,
0.030996656,
-0.0136124985,
0.008665518,
-0.016467804,
-0.027410924,
0.008008134,
0.012191487,
0.018738767,
0.016175633,
-0.0021912802,
0.0073241885,
0.0050100638,
0.010797036,
0.0036222527,
-0.0114411395,
-0.0025249526,
0.022882279,
-0.0046548108,
-0.016826376,
-0.642988,
-0.019761365,
0.0007831337,
-0.00437592,
0.01612251,
0.018061463,
-0.00073914207,
0.035113607,
-0.010750554,
0.012975035,
-0.00029362325,
0.014223401,
0.0070784995,
-0.014701499,
-0.01444917,
-0.020943327,
-0.0014484031,
-0.018698925,
-0.006630283,
0.024250168,
0.009661554,
-0.019960571,
-0.0036454936,
0.0035824112,
0.014489011,
0.023559583,
0.016507644,
-0.026082875,
0.00981428,
0.037265047,
-0.014316364,
0.030970095,
-0.009223298,
0.00545828,
0.04884563,
-0.00982756,
0.0047842953,
0.018473158,
0.019349668,
0.05216575,
-0.04008051,
0.008944408,
0.00059513183,
0.0009968665,
-0.020066814,
0.0009802659,
0.0019040898,
0.013864828,
0.009462346,
-0.005833454,
0.017516961,
0.018712206,
0.0038812223,
-0.01336681,
0.013386731,
0.020690998,
0.027490607,
-0.03978834,
0.0029549082,
0.0070784995,
0.0064277556,
0.018420035,
-0.022284657,
-0.0072909873,
-0.015856901,
0.02266979,
-0.021926083,
0.011905956,
0.010352139,
-0.014117157,
0.017304474,
0.029057706,
-0.029482681,
0.00218132,
0.015737377,
0.02974829,
0.004150152,
0.022815876,
-0.02046523,
0.015365523,
0.0018991096,
0.00043244584,
-0.00681953,
0.011812993,
0.030863851,
-0.033838682,
0.0005432549,
0.0120321205,
-0.028473364,
-0.0018493078,
0.038433727,
-0.00627503,
-0.0076495605,
-0.018420035,
0.004468884,
0.023333816,
0.0077890055,
0.004203274,
-0.007928451,
-0.039761778,
-0.008393267,
0.0018476477,
-0.0033234418,
0.008811603,
0.024303291,
0.00654728,
-0.024728267,
0.024130644,
0.02977485,
-0.016295157,
0.0013330289,
0.0021232178,
-0.020677717,
-0.0037450972,
-0.024515778,
-0.015418645,
0.01447573,
0.015192877,
0.02895146,
-0.022324499,
0.014555413,
0.019137181,
-0.0072909873,
-0.008844804,
0.022975242,
0.023413498,
-0.022842437,
0.0025780746,
-0.0006212778,
-0.005488161,
0.0084596705,
0.022045609,
0.015989706,
-0.014050755,
0.022364339,
0.0056807282,
0.017835693,
-0.012145005,
0.022218253,
-0.011773151,
-0.008838164,
0.008492871,
-0.004419082,
-0.0057936125,
-0.013499615,
-0.0143429255,
-0.016866218,
-0.011620426,
0.010850158,
-0.0011819634,
0.016335,
-0.0065937615,
-0.0245689,
0.022258095,
-0.016759975,
-0.017331036,
0.00038803922,
-0.0064875176,
-0.0019489115,
-0.00491378,
0.0039210636,
0.01444917,
-0.03418397,
-0.015511609,
-0.028606169,
-0.012523499,
0.019070778,
0.026574254,
-0.0050067436,
-0.016082669,
-0.00010432445,
-0.011899316,
-0.009143615,
0.0027922224,
0.006739847,
0.00060177204,
-0.0014367827,
0.0022045607,
-0.015644412,
-0.004336079,
0.0027889023,
-0.017769292,
-0.032271583,
-0.0056807282,
0.050306484,
-0.009581871,
0.0278359,
0.02018634,
0.0068925726,
0.03057168,
-0.01638812,
-0.007868689,
-0.01308792,
0.009701395,
0.007503475,
-0.024754828,
0.021421425,
-0.0039708656,
0.012994956,
0.011135688,
0.013499615,
-0.04010707,
-0.0093096215,
-0.015485047,
0.020624597,
-0.0041966336,
0.011388017,
-0.015963145,
0.02373223,
0.012901993,
0.010996243,
0.025830546,
-0.004946981,
-0.0028536445,
0.003977506,
-0.0040605087,
-0.017052146,
0.005534643,
0.003911103,
0.006759768,
-0.018911414,
-0.012503578,
0.023692388,
-0.016693572,
-0.016135791,
0.039921142,
0.012377414,
0.021673754,
-0.009017451,
-0.025843827,
-0.010146292,
-0.00084746105,
0.010982962,
0.00955531,
0.014542133,
0.009090493,
0.017955218,
-0.012716066,
0.021301901,
0.016162353,
0.028234314,
0.000299641,
0.025485255,
0.0042431154,
0.013227365,
-0.006636923,
0.032882486,
0.025989912,
-0.010478304,
0.005215911,
0.0034031246,
0.010206054,
-0.0076628407,
-0.03487456,
0.0020651156,
0.004963582,
0.0018742087,
-0.0107306335,
0.008147579,
0.018698925,
0.011846194,
-0.005020024,
-0.005023344,
-0.016281877,
0.0033749037,
0.024117364,
0.009050651,
-0.0018592682,
-0.011739951,
-0.01007989,
-0.013174242,
0.009887323,
-0.00655724,
-0.017238071,
0.00982756,
0.012569981,
0.021514388,
-0.0016916019,
0.03325434,
0.01253014,
0.002589695,
-0.017570084,
0.020571474,
0.01011309,
-0.009342822,
-0.03840717,
-0.013101201,
0.0025216325,
0.013811707,
0.0058367737,
0.017556803,
0.014860865,
0.019137181,
0.010066609,
-0.00096947554,
0.0009429146,
0.0043858807,
-0.042710043,
0.009449067,
0.018459877,
0.023652546,
0.009568591,
-0.005484841,
0.011102486,
0.019827766,
-0.019084059,
-0.018884853,
-0.02972173,
0.007589798,
-0.01091656,
-0.005398518,
-0.03136851,
-0.008838164,
0.006985536,
0.014515572,
0.0023572864,
-0.020239461,
-0.022457303,
0.002760681,
0.0026892985,
-0.027410924,
-0.028738974,
-0.025564937,
-0.024688425,
0.04175385,
0.036122926,
0.00082007004,
0.010206054,
0.010411901,
-0.007330829,
0.012928554,
-0.004780975,
0.021965925,
-0.0034429661,
-0.0030794127,
-0.025259485,
0.013944511,
-0.012251249,
0.013944511,
0.011899316,
-0.02427673,
-0.036388535,
-0.0054682405,
0.011686828,
0.016839657,
-0.011925877,
0.013054718,
0.049589336,
0.027357802,
-0.008592475,
-0.014821023,
0.005816853,
-0.01336017,
-0.0044622435,
-0.020624597,
-0.0072445055,
0.004671411,
0.02945612,
-0.01391795,
-0.011281773,
-0.00382146,
0.02322757,
0.012237969,
-0.016773256,
0.0041833534,
0.0058234935,
0.0006789649,
-0.0067265667,
0.020651156,
-0.028845217,
-0.0007607229,
0.028526485,
-0.023333816,
-0.0029051064,
0.024250168,
-0.03192629,
-0.021208936,
-0.0289249,
0.0106708715,
0.0003791164,
0.0034529266,
-0.025166523,
-0.030890413,
0.0051096673,
0.008738561,
-0.022204973,
0.020053536,
-0.007862048,
0.0034064448,
0.0010740594,
-0.0002701749,
-0.01145442,
-0.019509034,
0.017609926,
0.0021979206,
-0.018698925,
0.0021315182,
0.0011512522,
0.007065219,
0.0125567,
0.022590108,
-0.02290884,
-0.012098524,
0.010797036,
-0.0021099374,
-0.014236682,
-0.009435786,
-0.031474754,
-0.005986179,
0.016640449,
0.003957585,
-0.023147888,
-0.02865929,
0.0011678528,
0.02155423,
-0.011945798,
-0.0115208225,
-0.0039509446,
-0.012417255,
-0.0060559018,
0.022776034,
0.046587948,
-0.0034197252,
-0.020040255,
-0.00093710434,
-0.034980804,
-0.030996656,
-0.016587328,
-0.023108047,
-0.015086633,
0.010478304,
0.0046050088,
-0.016959181,
0.006215268,
0.007722603,
-0.011912596,
0.014940548,
-0.0025946752,
0.01309456,
0.022722913,
-0.0043061976,
0.015856901,
-0.006142225,
-0.012988316,
-0.006925774,
-0.011773151,
0.026401607,
0.025166523,
-0.030810729,
0.018234108,
-0.008685438,
0.0084795905,
-0.026667217,
0.01668029,
0.0136124985,
0.020412108,
-0.00327696,
-0.05219231,
-0.0121715665,
0.00791517,
-0.031076338,
-0.00015552696,
0.011666908,
-0.0072113043,
-0.007935091,
-0.022019047,
0.009595152,
-0.030704485,
0.044994287,
-0.042205386,
-0.013519536,
0.0061787465,
0.01116889,
0.0029432878,
-0.008373347,
0.006716606,
0.0078022857,
0.031235704,
-0.007722603,
-0.01743728,
0.008911206,
-0.011620426,
0.02889834,
0.03330746,
0.031820048,
0.005013384,
0.0061754263,
0.04773007,
0.012623102,
0.0099006025,
-0.003328422,
0.011978999,
-0.013207444,
0.028712412,
0.021487828,
0.023904877,
-0.014807743,
-0.012935194,
0.011228652,
0.031023217,
-0.012384054,
-0.02317445,
-0.021660473,
-0.07240521,
-0.021793278,
-0.0038048595,
-0.009847481,
-0.011427859,
-0.018366912,
-0.01718495,
0.0025830546,
0.009887323,
-0.0114012975,
-0.026627377,
0.014276523,
-0.023798632,
0.016826376,
0.00791517,
0.0038812223,
-0.01718495,
-0.0036786948,
0.0028735653,
0.0012915273,
0.0048639784,
-0.020319145,
0.01337345,
0.024316572,
-0.02211201,
0.0328028,
0.0008773421,
-0.008154219,
-0.013453133,
-0.01799506,
-0.027464047,
0.0018742087,
-0.00952875,
-0.028685851,
-0.022271376,
-0.005617646,
-0.010279097,
-0.02266979,
0.02812807,
0.0010176173,
-0.032165337,
0.011314975,
0.0016965822,
0.019230144,
-0.025989912,
0.037822828,
0.028765535,
0.000112054106,
-0.004266356,
-0.0053619966,
0.023293974,
0.007038658,
0.024582181,
0.016454523,
-0.0057770116,
-0.029934216,
0.0014160319,
0.010617749,
-0.015591292,
-0.038327485,
0.007390591,
-0.010033407,
0.013074639,
-0.0070784995,
0.009136975,
-0.021779997,
-0.014090597,
-0.01693262,
-0.0114212185,
-0.0076495605,
0.007051938,
0.009661554,
-0.0011296713,
-0.008014774,
0.022483865,
0.013878109,
0.005408478,
0.01253014,
-0.040505484,
-0.006195347,
0.0057006488,
-0.0032055774,
0.02074412,
-0.018645803,
0.010830237,
-0.0071382616,
0.009767798,
-0.004233155,
-0.0073839505,
-0.01666701,
0.03957585,
-0.021740157,
-0.00545496,
0.009176816,
-0.015139755,
-0.009508829,
-0.0120520415,
0.00709842,
0.0055313227,
-0.009017451,
-0.010518146,
0.020624597,
0.02644145,
0.006510759,
-0.009781078,
-0.038619656,
0.0055014417,
-0.024754828,
-0.02617584,
0.00057687116,
-0.031262267,
0.01609595,
-0.00092050375,
0.0048739384,
0.01855284,
0.008891285,
-0.008652237,
0.006520719,
0.020478511,
-0.02290884,
0.013519536,
-0.0073706703,
-0.022284657,
-0.013824986,
0.02102301,
-0.016813096,
-0.014303084,
0.004266356,
-0.009402584,
-0.024449376,
0.007330829,
0.0016700212,
0.016454523,
0.0033101614,
0.01612251,
-0.0033881841,
0.009037371,
0.027384363,
-0.025445413,
-0.027995266,
0.01528584,
-0.008565914,
0.008698719,
0.011308335,
-0.031501316,
0.004392521,
-0.0032288183,
0.010823596,
0.011075926,
0.016308438,
-0.007317548,
-0.020398827,
0.0041036704,
0.013273846,
-0.007988213,
-0.015524889,
-0.03057168,
-0.031873167,
0.020757401,
-0.015963145,
-0.012125084,
-0.024648583,
0.017025584,
0.024794668,
0.0085194325,
0.011374737,
0.009256499,
-0.0053653168,
-0.011215371,
-0.036601022,
-0.005647527,
-0.0024884313,
0.035830755,
0.020252742,
0.0048141764,
-0.011540743,
-0.0030644722,
-0.014396047,
-0.023639265,
0.019761365,
0.020704279,
0.009913883,
0.013220725,
0.008572554,
0.03357307,
0.022311218,
-0.00021477036,
-0.024648583,
-0.0038613016,
0.015524889,
0.00079184904,
0.026600815,
0.0048440574,
-0.015418645,
-0.010883359,
0.018340353,
-0.031846605,
-0.016335,
0.0034263656,
0.0040306277,
0.014900706,
-0.026879705,
0.008711999,
0.012118444,
-0.0000144606865,
-0.0037816186,
-0.027915584,
-0.017357595,
-0.0040239873,
-0.02757029,
-0.013745303,
-0.009482267,
-0.01718495,
-0.017384157,
0.0027938823,
-0.009933804,
-0.013074639,
0.013904669,
-0.005750451,
0.019044219,
0.019748084,
0.002428669,
0.02078396,
0.0015745678,
-0.009734597,
-0.026614096,
-0.011374737,
-0.014648377,
0.0025797344,
-0.013546096,
-0.008247182,
-0.011653627,
-0.019309828,
0.00626507,
-0.014661658,
0.0038015393,
-0.0278359,
-0.011348176,
-0.021633912,
0.034529265,
-0.009030731,
0.0042630364,
-0.005564524,
0.033440266,
0.014595255,
-0.028845217,
-0.016759975,
-0.02209873,
0.016919341,
-0.014356206,
0.008008134,
-0.0143827675,
0.007483554,
-0.025551656,
-0.01853956,
-0.019748084,
-0.00078769884,
0.17700233,
-0.01581706,
0.004126911,
0.013101201,
0.0031292147,
-0.0023539662,
0.03251063,
-0.015365523,
-0.00871864,
-0.0021082773,
-0.0035691308,
0.017848974,
-0.0038845423,
0.0033964845,
0.029349875,
-0.044648997,
-0.0028835256,
0.013599219,
0.008559274,
-0.011255212,
-0.0050963867,
-0.026335206,
-0.008612395,
-0.012795749,
0.04281629,
0.002760681,
-0.033466827,
-0.018034901,
-0.0073042675,
0.014316364,
-0.011500902,
-0.023692388,
0.004751094,
0.015870182,
-0.007862048,
-0.021129254,
-0.010159573,
-0.0054217586,
0.009362743,
-0.014369487,
0.0044921245,
-0.006165466,
0.005491481,
-0.00046564706,
0.007968292,
0.01527256,
-0.0034363258,
-0.012523499,
-0.021713596,
0.0068394504,
-0.038168117,
-0.0051727495,
0.015352243,
0.04071797,
0.014980389,
0.0072710663,
0.018366912,
-0.007556597,
-0.008931127,
0.028685851,
-0.016826376,
0.0048141764,
-0.03556514,
0.011268493,
-0.015737377,
0.05344068,
-0.03516673,
0.030306071,
0.0024801309,
-0.004256396,
-0.010159573,
-0.028446803,
-0.014674937,
0.005215911,
-0.006992176,
-0.0021431386,
0.020584755,
0.022231534,
0.025033718,
0.0014674938,
-0.013811707,
0.0062551093,
-0.0150335105,
0.015910024,
-0.011049365,
-0.020757401,
0.025485255,
0.005401838,
-0.047305092,
-0.0026776781,
-0.0084198285,
-0.036096364,
0.0026726979,
-0.016414681,
0.010239256,
-0.011062645,
0.011507542,
0.0240244,
0.0017546843,
-0.028632728,
-0.02128862,
0.04419746,
0.01391795,
0.020266023,
-0.009143615,
0.011288414,
-0.01446245,
0.036176044,
-0.004007387,
-0.03601668,
0.016759975,
-0.00926978,
0.020531632,
-0.018951254,
-0.0058367737,
-0.002103297,
0.011706749,
-0.025989912,
0.021195658,
-0.019787924,
-0.02483451,
-0.03822124,
-0.010989603,
0.022019047,
-0.02344006,
-0.03795563,
-0.026481291,
-0.035352655,
-0.022536986,
-0.03155444,
-0.011148969,
-0.037344728,
-0.01745056,
-0.01308792,
0.010684151,
-0.02015978,
0.009216658,
-0.0071316212,
-0.02618912,
0.031740364,
-0.013758584,
-0.0064310757,
0.018712206,
-0.008326865,
0.0074304324,
-0.035379216,
-0.0004801726,
0.019416071,
0.007204664,
0.016335,
-0.024595462,
-0.025684461,
0.01036542,
0.008220621,
0.023798632,
-0.016228754,
-0.0074901944,
-0.049987752,
-0.007955012,
-0.00006142225,
-0.021102693,
0.01199892,
0.013041438,
0.0038712618,
0.016494364,
-0.0012782469,
-0.16754662,
0.012125084,
0.016985742,
-0.017264633,
0.013824986,
0.007622999,
0.015790498,
-0.01938951,
0.014714779,
0.01228445,
-0.00013685126,
0.025737584,
-0.05317507,
-0.030890413,
0.025272766,
0.023891596,
-0.005601045,
0.027158596,
0.024661863,
0.008101097,
0.029137388,
-0.038115,
0.014183559,
-0.013247285,
-0.0015795479,
0.026003193,
0.015498328,
-0.008253822,
0.0042397953,
-0.035379216,
-0.019323109,
0.021408144,
0.018207546,
-0.003931024,
-0.0005378597,
-0.0023904876,
-0.036361974,
-0.00016538356,
-0.013333608,
0.003572451,
0.029429559,
0.023426779,
0.005597725,
0.010518146,
0.0005233342,
-0.0025996552,
-0.015511609,
0.009654914,
0.033652753,
-0.023971278,
0.024170486,
0.005295594,
0.01555145,
0.0015587971,
0.014183559,
-0.0055612037,
-0.00018852066,
0.031580996,
0.00218298,
0.0029980699,
-0.007795646,
-0.0030412315,
0.035060484,
0.026388327,
0.015604571,
-0.007344109,
-0.028978022,
0.013798426,
-0.022868998,
0.02512668,
-0.016547486,
0.005152829,
0.011102486,
-0.006294951,
0.05370629,
0.005551243,
-0.023665827,
0.0008076196,
-0.0068394504,
-0.008824883,
-0.00056110055,
0.014821023,
-0.016693572,
-0.02589695,
-0.030252948,
0.014714779,
0.018738767,
0.014555413,
0.009024091,
0.0056110057,
0.018459877,
-0.043905288,
-0.0017414038,
-0.024197048,
0.011208731,
0.015206157,
-0.013745303,
-0.015166316,
0.028978022,
0.0012085243,
0.0061023836,
-0.019216863,
-0.0015720776,
-0.0011628726,
0.022019047,
-0.0077093225,
-0.016959181,
-0.013154322,
0.0278359,
0.01881845,
-0.008101097,
0.01772945,
-0.009641633,
0.035777632,
-0.014236682,
0.030624803,
0.006792969,
-0.018420035,
0.019987132,
-0.025684461,
0.06741175,
0.015684254,
0.0028984663,
0.020969888,
-0.0019787925,
-0.039735217,
-0.11293726,
-0.017410718,
-0.009847481,
0.043852165,
-0.0043792403,
0.0060691824,
0.013074639,
0.028978022,
-0.020279303,
0.020412108,
-0.016985742,
-0.000113714166,
-0.017105266,
-0.006185387,
0.021594072,
-0.007901889,
0.005302234,
-0.0063746334,
-0.013160963,
0.040771093,
0.0043261186,
-0.010006847,
-0.0039343443,
0.007881969,
-0.010465023,
0.006666804,
-0.01778257,
0.025817266,
0.011600506,
0.020518351,
0.0058832555,
0.00015718701,
0.0011844534,
-0.003602332,
-0.028154632,
-0.037211925,
-0.0025813945,
-0.010411901,
0.02567118,
-0.020837083,
0.000016859993,
0.00872528,
0.016281877,
0.005786972,
0.012729347,
0.003301861,
0.01799506,
0.011886036,
-0.00040007467,
-0.017370876,
-0.039708655,
-0.029031144,
-0.04045236,
-0.0027972024,
0.042630363,
-0.014303084,
0.006879292,
0.0042464356,
0.014608535,
-0.0016882819,
0.0038878624,
0.037158802,
-0.024236888,
-0.012330932,
0.013625779,
-0.016228754,
-0.027437486,
-0.014887425,
-0.0014840944,
-0.04826129,
0.008579195,
0.006846091,
-0.007749164,
-0.006338112,
-0.03710568,
0.010345499,
0.001962192,
-0.0027141995,
-0.01173331,
-0.017331036,
-0.0049436614,
-0.014674937,
0.011660268,
-0.03211222,
0.005478201,
0.01883173,
0.024914194,
-0.0023855073,
0.024236888,
-0.0034994083,
-0.017264633,
0.008559274,
-0.002319105,
-0.026282083,
-0.009628353,
-0.0024602101,
-0.012397334,
-0.01605611,
0.020943327,
0.003115934,
-0.03224502,
-0.002813803,
-0.053785972,
0.03413085,
-0.0003876242,
-0.004425722,
-0.0077358834,
-0.021049572,
0.010259176,
-0.0020036935,
0.0028055029,
0.030412314,
-0.0049868226,
0.0071316212,
-0.007948372,
-0.008791682,
-0.023134608,
-0.0251134,
0.0150733525,
0.012696145,
0.037902508,
0.028234314,
0.009568591,
0.022815876,
0.0066236425,
0.012536779,
-0.025777424,
0.014767901,
-0.014847584,
-0.021408144,
-0.006958975,
-0.0025963353,
0.012543419,
-0.036919754,
-0.003931024,
-0.0077690845,
-0.004608329,
0.0009362743,
0.00245191,
0.037211925,
0.011016164,
0.0278359,
-0.008028055,
-0.037530657,
0.0100002065,
-0.023201011,
-0.014183559,
-0.0012126744,
0.0024336493,
0.014807743,
0.0048805787,
0.014635096,
0.029243631,
0.0012433856,
0.00245689,
-0.021899523,
0.007178103,
-0.011434499,
-0.0067232465,
-0.0031341948,
-0.021195658,
-0.0010499884,
0.013207444,
0.01774273,
0.0043825605,
-0.015139755,
0.010969682,
-0.034847997,
-0.026109437,
0.006188707,
-0.016759975,
-0.02977485,
-0.030093582,
0.004176713,
0.019535596,
0.022643229,
-0.015086633,
0.0014832644,
-0.013287127,
-0.011932517,
-0.011965718,
0.01855284,
0.0075964383,
0.013021518,
-0.021926083,
0.006112344,
0.007808926,
0.009409225,
0.0039509446,
0.015126474,
0.0011504221,
-0.0033101614,
-0.0055280025,
0.007476914,
0.006879292,
0.00083044544,
0.007842127,
0.010451743,
-0.016494364,
0.009316262,
-0.00033699235,
0.008990889,
-0.0005332945,
0.0014110517,
0.0037550577,
-0.017848974,
0.008612395,
0.004126911,
-0.00028324788,
-0.03500736,
-0.00078147365,
0.022351058,
0.0016708513,
-0.0033168015,
-0.012145005,
-0.0047876155,
-0.00030918632,
0.028978022,
-0.0058832555,
-0.012118444,
-0.02349318,
0.009468987,
0.02050507,
0.022151852,
-0.02015978,
-0.003170716,
-0.00060675223,
0.013346889,
0.031527877,
-0.008864725,
0.0054682405,
0.0038646215,
0.025219643,
-0.023121327,
-0.011507542,
-0.014316364,
0.00163599,
-0.020239461,
0.020850364,
0.011587225,
-0.023094766,
0.08361395,
0.02127534,
-0.016826376,
0.019827766,
-0.027052352,
0.019973852,
-0.030651363,
0.013227365,
-0.041355435,
-0.02972173,
0.016507644,
-0.032138776,
0.013021518,
-0.015883463,
-0.008373347,
0.030465437,
-0.02316117,
0.01011309,
-0.002676018,
-0.032351267,
0.011414578,
-0.031873167,
-0.0036753747,
0.0068128896,
-0.01447573,
0.0064841975,
0.030306071,
0.012662944,
0.023254132,
-0.021501107,
-0.006195347,
-0.00012232573,
-0.028606169,
0.014621816,
0.014940548,
0.0013703802,
0.0022842437,
-0.008984249,
0.017862255,
0.00545828,
-0.023373656,
-0.007795646,
-0.0007943391,
0.011886036,
0.012437176,
0.009376024,
-0.014781182,
0.008267103,
-0.021926083
] |
H2-M3 is a class Ib MHC molecule of the mouse with a 10(4)-fold preference for binding N-formylated peptides. To elucidate the basis of this unusual specificity, we expressed and crystallized a soluble form of M3 with a formylated nonamer peptide, fMYFINILTL, and determined the structure by X-ray crystallography. M3, refined at 2.1 A resolution, resembles class la MHC molecules in its overall structure, but differs in the peptide-binding groove. The A pocket, which usually accommodates the free N-terminus of a bound peptide | [
-0.017475437,
0.0039436906,
-0.029701548,
-0.018694032,
-0.0058954493,
0.023005977,
-0.027639313,
-0.0009708576,
-0.015721198,
-0.013317488,
0.0082891155,
0.008309202,
0.013705832,
-0.010974039,
-0.0016169802,
0.0038666916,
0.02596542,
0.013491574,
-0.007840512,
-0.0035118265,
-0.017649522,
0.008255637,
-0.008945282,
-0.032165516,
-0.004777289,
0.02289885,
0.01751561,
-0.034950875,
-0.010411611,
-0.005212501,
0.013940177,
0.0046802033,
-0.010766476,
0.00669557,
0.0010470197,
0.009795619,
0.020783048,
0.005055155,
0.017020138,
-0.001338277,
0.025523512,
0.019189503,
0.009407275,
0.021465996,
-0.0098826615,
-0.005152241,
0.0044893795,
-0.014904339,
-0.035915036,
0.008958672,
0.013625485,
0.014355302,
-0.0037796493,
-0.008664068,
-0.01937698,
-0.00015985673,
0.027358098,
0.00964162,
-0.0002569425,
-0.028737387,
-0.0010687803,
0.0018396078,
-0.019631412,
0.004840897,
0.034093842,
-0.0025761204,
-0.014783818,
0.016484493,
0.006923219,
-0.012185937,
0.014194609,
0.001230311,
-0.007505734,
0.004733768,
0.049761474,
0.0073249536,
-0.030719275,
0.0004887766,
0.010284395,
-0.0045094662,
0.018104821,
-0.0148106,
-0.017689696,
0.03819153,
0.016511275,
0.011402556,
0.022028426,
0.00917293,
0.0037294324,
-0.011777507,
0.03184413,
0.014917729,
0.0012863864,
0.015721198,
-0.012540802,
-0.0014077435,
-0.001759261,
0.02384962,
0.033397503,
-0.00399056,
-0.018707423,
0.018386034,
-0.015734589,
-0.01656484,
-0.016310409,
0.0006122262,
-0.012105591,
-0.022738155,
0.0155471135,
-0.009239887,
0.0019115852,
0.031469177,
0.0077266875,
-0.03829866,
0.004325338,
-0.010994126,
0.029862242,
-0.019577846,
0.009601447,
-0.002241342,
-0.003829866,
0.035191916,
-0.004566379,
-0.01703353,
0.017796826,
0.017448654,
-0.020876788,
-0.026420718,
-0.008429723,
0.0028857905,
0.059885178,
0.003018028,
0.01098743,
-0.0031318527,
-0.025992202,
0.025697598,
-0.029299814,
-0.010813345,
0.00408095,
-0.03583469,
-0.002243016,
0.035781126,
-0.005630974,
0.003736128,
-0.0012729953,
0.019229677,
0.0201001,
0.011797594,
-0.011375774,
-0.012540802,
-0.0035118265,
-0.01204533,
0.0018362601,
0.018519945,
0.020890178,
0.029862242,
-0.028576693,
0.0116837695,
-0.021680254,
-0.01644432,
0.0006787634,
-0.008777892,
0.020234013,
-0.0011089537,
0.013069753,
0.025309253,
0.010016573,
0.006688874,
-0.00968849,
0.014194609,
-0.004720377,
0.01387322,
0.016752316,
0.006551615,
-0.010237526,
0.007411996,
0.036156077,
0.007673123,
-0.0048007234,
-0.020287577,
0.009494318,
0.023742491,
0.025322646,
-0.013752701,
-0.025309253,
0.027826788,
0.024050487,
-0.02632698,
0.016122932,
-0.020582182,
0.007987815,
0.002929312,
0.0001516965,
-0.008951977,
-0.6376325,
-0.021640083,
0.018573511,
-0.017488828,
-0.01975193,
0.04285165,
0.0119181145,
-0.00029837133,
-0.0062503144,
0.01739509,
-0.013913394,
0.0296212,
0.015707808,
-0.03489731,
-0.024104051,
-0.02303276,
0.005600844,
-0.026969755,
0.01432852,
-0.012781843,
-0.0101437885,
-0.0007206107,
-0.0025761204,
0.006615223,
0.0044692927,
-0.0069031324,
0.006283792,
-0.027425054,
-0.009313538,
0.01204533,
-0.029862242,
0.010244222,
-0.011764117,
-0.013016188,
0.053403866,
-0.015185553,
0.014087479,
0.018386034,
0.022135554,
0.009393885,
0.0039872117,
-0.0001081753,
-0.0034515662,
0.015881892,
-0.0253896,
0.02879095,
-0.000116754,
0.01598902,
0.0071374774,
-0.011904723,
-0.0038265183,
0.0034917397,
-0.024773609,
0.006099664,
0.0070035663,
-0.0070169573,
0.028978426,
-0.02445222,
0.014033915,
-0.005707973,
0.013993741,
-0.0029058773,
-0.022470333,
-0.03136205,
-0.010271004,
-0.008898413,
-0.011174906,
0.007191042,
0.007673123,
0.019899234,
-0.0063239657,
0.033290375,
-0.010659347,
0.0062971837,
0.0074923425,
0.04536918,
-0.0076999054,
-0.0029309858,
-0.002229625,
0.019792104,
0.0042851646,
-0.0015307746,
-0.01251402,
0.000825229,
0.025804726,
-0.017100485,
-0.015707808,
0.018278906,
0.0031318527,
0.029808678,
0.012822016,
-0.014596342,
0.01033796,
-0.020073319,
-0.017247789,
0.015413202,
-0.006009274,
0.0009733685,
0.015560504,
-0.014703471,
-0.013518356,
-0.010311178,
0.022296248,
-0.028710604,
0.020113492,
0.008108336,
-0.02865704,
0.017582567,
0.029112337,
-0.027505402,
-0.01221272,
-0.0011432685,
-0.03559365,
-0.005396629,
-0.005537236,
-0.022724764,
0.014770427,
0.020126883,
-0.0060594906,
-0.04826167,
0.016993357,
0.007873991,
-0.0013650593,
0.002847291,
0.027411664,
0.018546728,
0.012801929,
-0.011904723,
-0.01175742,
-0.006682179,
0.023206845,
-0.0038700395,
0.020434879,
-0.020300968,
0.020903569,
0.010719608,
0.012955928,
0.016712142,
-0.013304098,
-0.020823222,
-0.034870528,
0.0025409688,
-0.0150516415,
-0.010137093,
-0.0030582016,
-0.021707037,
-0.017783433,
-0.0074521694,
0.010672739,
-0.014060697,
0.013143403,
0.014931121,
-0.002755227,
0.006518137,
0.00986927,
-0.007867294,
-0.004067559,
-0.0027903789,
-0.0007603657,
-0.018011084,
-0.015239117,
0.024412047,
-0.014368693,
0.010920474,
-0.007191042,
-0.004204818,
0.0022145598,
0.029808678,
0.00093319506,
-0.049868606,
-0.004499423,
-0.009413972,
-0.028978426,
0.0068897414,
-0.0014763732,
0.022764938,
0.015801545,
-0.013297402,
-0.024733435,
-0.0040139942,
0.004157949,
-0.008155204,
0.025242299,
0.0060460996,
0.030692492,
-0.0037629104,
0.014127652,
0.00504846,
0.00199528,
0.02244355,
0.017890563,
-0.0029845503,
-0.00915954,
0.02066253,
-0.007873991,
-0.011931506,
0.0149980765,
-0.010210744,
0.0014403844,
0.033397503,
0.0050986763,
-0.0007469745,
0.007947641,
-0.016484493,
0.022028426,
-0.035432957,
0.0018948463,
-0.02056879,
0.018359253,
0.017997691,
-0.013431313,
0.0002774477,
-0.0021693646,
-0.027304534,
0.0063942694,
0.01180429,
-0.012775147,
-0.0044927276,
-0.0052526747,
-0.01550694,
0.016363973,
0.019202894,
-0.0030247236,
0.0056912345,
0.008362766,
-0.023568407,
0.027666096,
0.0110343,
0.0022597548,
-0.01914933,
-0.01937698,
-0.005403325,
0.011382469,
0.020448271,
0.021693647,
-0.0010579,
0.016671969,
-0.005714669,
0.042690955,
0.0034783485,
0.0011315513,
0.022349812,
-0.0029008556,
0.008985455,
0.020528618,
-0.028255304,
0.0073249536,
0.0015960565,
0.012219415,
0.015600678,
-0.006789308,
-0.00041533457,
-0.018265516,
0.0045965086,
-0.0082891155,
0.00038666915,
0.009574665,
0.011951592,
0.038727175,
0.016189888,
-0.019939408,
0.009782228,
0.0017207614,
-0.022711374,
0.01598902,
-0.00342311,
-0.021760602,
-0.02126513,
-0.016471103,
-0.004479336,
-0.022952413,
0.0139535675,
0.0008486635,
-0.01005005,
0.000724377,
0.004486032,
0.010686129,
-0.00020693496,
0.01845299,
0.0017207614,
-0.037763014,
-0.048208103,
0.0216133,
0.039637774,
-0.016658578,
-0.0008185334,
-0.02159991,
0.01434191,
-0.0045362487,
0.0009934552,
-0.017087094,
-0.0016002412,
0.010043355,
0.011302122,
-0.02679567,
-0.015158771,
0.039262824,
-0.004452554,
0.002243016,
0.010766476,
-0.016417537,
-0.0029862241,
-0.017662913,
0.0016605014,
0.039182477,
0.0068127424,
-0.0027133797,
-0.01310323,
-0.0012093873,
0.00781373,
-0.0011893006,
0.0071843467,
-0.0041512535,
0.0008377832,
-0.012755061,
0.030719275,
0.007880686,
0.012855494,
0.026246633,
-0.027692877,
-0.0016621753,
-0.030638928,
-0.0046400297,
-0.011328904,
0.00631727,
0.02208199,
0.009085888,
-0.00020180867,
0.011703856,
0.005835189,
-0.017127268,
-0.01479721,
0.027666096,
-0.00258449,
-0.012005157,
0.01268141,
0.0036691723,
0.0085502425,
0.0077601657,
0.0033059376,
-0.010331265,
-0.021814167,
0.009634925,
0.015841719,
0.005135502,
-0.011938201,
0.00445925,
0.008389549,
0.016993357,
0.006524833,
0.0023250366,
0.022590853,
0.011476207,
-0.03703989,
0.038057618,
-0.006809395,
0.018667249,
-0.0015927086,
0.0049145482,
-0.028389217,
-0.01787717,
0.009306842,
0.011583336,
-0.00034335718,
-0.008208768,
0.028174957,
-0.00058251456,
0.012199328,
-0.01174403,
-0.022523897,
0.0023467971,
0.007867294,
-0.0072446065,
-0.0139535675,
0.015359637,
-0.026179679,
0.00986927,
-0.02255068,
0.006568354,
0.009065801,
-0.0073852134,
-0.023996923,
-0.007860599,
-0.021425825,
-0.0062938356,
-0.048690185,
0.029889025,
0.0011223449,
-0.008416331,
-0.013900003,
-0.032620817,
-0.007659732,
-0.035406172,
-0.018024474,
0.028871298,
-0.0055472795,
-0.011020908,
-0.0014956229,
-0.0111079505,
0.0059958827,
-0.009474232,
-0.0075927763,
0.0022363204,
0.035406172,
-0.011014213,
-0.0029560942,
-0.0017190876,
-0.014020523,
0.005195762,
0.015922066,
0.0037595625,
-0.01098743,
-0.011469511,
-0.018640466,
-0.0075592985,
-0.024479004,
0.0041780355,
0.00012679736,
-0.015560504,
0.009956312,
0.012688105,
0.025978811,
-0.009996486,
-0.0035921733,
0.0015173835,
-0.021894513,
-0.03066571,
-0.011014213,
0.0013751027,
-0.0013834721,
0.01691301,
0.02761253,
-0.02583151,
-0.008603808,
-0.0008499189,
-0.014515996,
0.0063139223,
0.016189888,
0.024720045,
0.034013495,
-0.015105206,
0.012855494,
-0.009735359,
-0.023822838,
-0.0026648368,
-0.030130064,
0.025456557,
-0.0009507709,
-0.032245863,
0.021532953,
0.008148508,
-0.02243016,
0.012755061,
-0.0036859112,
-0.0035419564,
0.03725415,
0.0071039996,
-0.022229291,
0.0030481583,
-0.020287577,
-0.02879095,
0.009661707,
0.005152241,
-0.0016546428,
-0.0050685466,
0.018426208,
-0.0095679695,
0.004706986,
-0.016069368,
-0.026541239,
-0.017595958,
0.016645188,
-0.025242299,
0.009246582,
-0.018600293,
0.0067993514,
-0.010953953,
-0.018760987,
-0.01527929,
-0.011496293,
0.0019684976,
-0.01680588,
0.028737387,
0.039557427,
0.027826788,
0.008175291,
0.029433725,
0.010579,
0.0006473779,
0.019966189,
-0.004315295,
0.010712912,
-0.004338729,
0.012781843,
0.012380109,
-0.014596342,
0.0078070345,
-0.014141044,
0.024787,
-0.0038533006,
0.00657505,
-0.013404531,
-0.0056778435,
-0.043521203,
-0.012025244,
0.0064210515,
-0.010585696,
-0.0018479773,
-0.039289605,
-0.034147408,
0.0111615155,
-0.0055271927,
0.0055539752,
-0.0069968705,
0.038673613,
-0.026889408,
0.028817734,
-0.012460455,
0.016390756,
0.0045195096,
0.0073450403,
-0.0016847728,
0.0018379339,
0.008510069,
-0.009152844,
0.014917729,
0.027666096,
-0.016765706,
0.0100634415,
0.005999231,
-0.012380109,
-0.00513885,
-0.018827943,
-0.0035888255,
-0.002378601,
-0.014703471,
-0.011851159,
-0.03677207,
0.011382469,
0.0056276266,
-0.012018548,
0.016538057,
-0.013598703,
-0.0004728746,
0.038673613,
0.0025543598,
0.029326595,
-0.03677207,
0.01192481,
0.020140273,
0.00021676907,
-0.029031992,
-0.024586132,
-0.014676689,
0.014141044,
0.0453424,
0.009005542,
-0.0012169199,
-0.015721198,
0.0013047992,
0.0127282785,
-0.010953953,
-0.052573614,
0.01703353,
0.018064648,
0.0062938356,
-0.035299044,
-0.0010202375,
-0.03489731,
0.029514072,
-0.0055673663,
0.020903569,
-0.0055774096,
-0.026273416,
-0.03465627,
0.022872066,
0.016524667,
0.017207615,
0.005694582,
-0.017194223,
0.012400196,
-0.034575924,
-0.0015542092,
-0.0031318527,
0.0056744954,
0.025871683,
-0.021425825,
-0.011007517,
0.00875111,
0.0033980017,
-0.02126513,
0.00917293,
0.0039771684,
0.033772454,
-0.029192684,
-0.000028979264,
0.014355302,
0.015091815,
-0.0034984353,
-0.010284395,
0.013766091,
-0.023635361,
-0.017167442,
0.009983094,
0.029353378,
-0.005460237,
0.005322978,
-0.0050718943,
-0.0054234117,
-0.006929915,
-0.04547631,
-0.010009877,
-0.0024304918,
-0.03312968,
-0.017301353,
-0.01597563,
0.017006747,
0.027880354,
-0.01385983,
-0.01086691,
-0.005694582,
0.03256725,
-0.01925646,
0.011121342,
0.018144995,
0.007365127,
-0.021104436,
-0.0134848775,
-0.009347016,
-0.010953953,
0.016671969,
-0.024787,
-0.03157631,
-0.0073249536,
0.0007201922,
0.020542009,
0.0139803495,
-0.023916576,
-0.0021743863,
0.0014914382,
0.022323031,
0.00840294,
-0.006551615,
0.025282472,
-0.027800007,
-0.00009185485,
0.0098290965,
-0.0053129345,
-0.0124671515,
0.0019065635,
-0.042128526,
0.0013140056,
-0.019684976,
0.0074655605,
-0.021787385,
0.007398605,
-0.012601063,
-0.0068428726,
-0.022979196,
0.0029058773,
-0.012185937,
0.011944897,
0.009032324,
-0.007237911,
-0.023313975,
-0.004656769,
0.01333088,
-0.0015383072,
-0.027585749,
-0.013417922,
0.023340756,
-0.03511157,
-0.026527848,
-0.0034030234,
-0.025791336,
0.047511764,
0.006504746,
-0.0148106,
-0.009614838,
0.004345425,
-0.04721716,
0.003158635,
-0.0067759166,
0.009132758,
0.0042985557,
0.0042550345,
-0.008021293,
0.025081605,
-0.001991932,
-0.010445089,
-0.013592007,
-0.01222611,
0.0017960867,
-0.02350145,
0.018734206,
0.031040663,
-0.008356071,
0.0017174137,
0.024197789,
0.0032138736,
-0.008831456,
0.03663816,
-0.017944127,
0.0119181145,
-0.018011084,
0.0051890668,
-0.008021293,
0.014207999,
0.026085941,
-0.010880301,
-0.0074521694,
-0.0034950874,
-0.010813345,
0.0023434495,
-0.011489598,
-0.008115031,
-0.001960128,
0.004372207,
0.005630974,
-0.033665325,
0.0023451233,
-0.01387322,
0.010813345,
0.0011566597,
-0.017582567,
0.011563249,
0.0033427633,
-0.005497063,
0.001401048,
0.011603422,
-0.028174957,
-0.015346246,
0.0030247236,
0.0028238567,
0.00062352495,
-0.005025025,
-0.016310409,
-0.021251738,
-0.0080279885,
-0.013705832,
-0.01596224,
-0.017087094,
-0.0067290477,
-0.0031820696,
-0.027076885,
-0.0051890668,
-0.01479721,
-0.0033578284,
-0.00980901,
0.026634976,
-0.0022815154,
-0.0007565994,
-0.021104436,
-0.0067826123,
-0.030612146,
-0.0043688593,
-0.001618654,
-0.009842488,
-0.0003337323,
-0.0020321056,
0.19786748,
-0.01222611,
0.0080279885,
0.0258449,
0.021345478,
0.008456505,
0.0019567802,
-0.01736831,
0.011462816,
0.007827121,
0.022470333,
0.016671969,
-0.030156847,
0.0000065026798,
0.0077936435,
-0.0012545824,
-0.03864683,
-0.004181383,
-0.047672458,
-0.005389934,
-0.00024062204,
0.012955928,
0.0032406559,
0.0013416248,
0.028041046,
-0.0067993514,
-0.019992972,
-0.009085888,
-0.03347785,
0.023555014,
-0.028335651,
-0.00095495564,
0.011348991,
-0.003300916,
-0.004422424,
0.020033145,
-0.032272648,
-0.008302507,
0.004857636,
0.033156462,
-0.027666096,
0.008516765,
-0.006334009,
-0.0070169573,
0.009266669,
0.018171776,
0.0075860806,
-0.005808407,
-0.026594805,
0.0041914266,
-0.026835844,
0.009139453,
0.013230446,
0.035191916,
0.007331649,
-0.007318258,
-0.008623894,
0.003736128,
-0.013063057,
0.0095947515,
-0.018975245,
-0.007425387,
-0.017073704,
0.047056466,
-0.0067826123,
0.025215516,
-0.024853956,
0.010183962,
0.010311178,
-0.014047306,
-0.001136573,
0.0022631027,
-0.02032775,
-0.013411227,
-0.023581797,
-0.00052350987,
0.053484213,
0.015426593,
0.0057481467,
0.023929967,
0.0006051121,
-0.025282472,
-0.01456956,
-0.012011852,
-0.002850639,
-0.023300583,
0.020126883,
0.017341526,
-0.0026095985,
-0.01739509,
0.009246582,
-0.016015803,
-0.008315898,
-0.015533722,
0.0016136323,
-0.002068931,
0.015453375,
0.020943742,
-0.019658193,
0.0035553477,
-0.01821195,
0.05297535,
-0.006103012,
0.01596224,
-0.019684976,
-0.008543547,
-0.012112286,
0.018948464,
-0.00011382469,
-0.01633719,
0.024532568,
-0.040280547,
-0.012801929,
-0.018144995,
0.014877556,
0.008148508,
-0.0075124293,
-0.02806783,
0.03361176,
-0.019350197,
-0.015212335,
-0.0101170065,
0.0031151138,
0.04137862,
0.00037034872,
0.0152659,
-0.012192633,
-0.0012939189,
0.0062804446,
-0.035620432,
0.0038633437,
0.0074923425,
0.010967343,
-0.0064813117,
0.004636682,
-0.007237911,
-0.020367924,
-0.014703471,
-0.017448654,
0.02362197,
-0.011643596,
-0.01479721,
0.005386586,
-0.000044227378,
-0.004167992,
-0.007191042,
0.023180064,
0.0025091649,
-0.011308817,
-0.0055004107,
0.0067323954,
-0.034227755,
-0.022939023,
-0.022992587,
0.03479018,
-0.013156795,
-0.01656484,
-0.01984567,
-0.013116621,
0.012145764,
-0.0201001,
0.012935841,
0.029058773,
-0.006508094,
0.004757202,
0.008617198,
-0.16915688,
0.022872066,
0.023568407,
-0.0044692927,
0.027692877,
-0.00286403,
0.013297402,
-0.0060327086,
0.00006141093,
0.012627845,
0.025282472,
-0.0066353097,
-0.015640851,
-0.022363203,
-0.0005410857,
0.022349812,
-0.01644432,
0.016297016,
0.0040139942,
0.0033092855,
0.021412432,
-0.007840512,
0.022805111,
-0.025215516,
0.015359637,
0.03382602,
-0.013263924,
-0.00044107068,
-0.010103615,
0.0022246032,
0.0045965086,
-0.0066989176,
0.047752805,
0.011556554,
0.044244327,
-0.001058737,
-0.015788155,
-0.0113958595,
-0.008483287,
0.028844515,
0.016966574,
0.0043487726,
0.0059054927,
-0.013049666,
-0.021800775,
-0.0060929684,
0.01691301,
0.020314358,
0.048208103,
-0.004234948,
0.034950875,
-0.013993741,
0.026876017,
0.011569945,
0.027960699,
0.000014136545,
-0.0067290477,
0.022483723,
-0.000024362982,
-0.020970525,
-0.020140273,
0.004814115,
0.028844515,
-0.011964983,
0.010257613,
-0.023273801,
-0.002597881,
0.02008671,
-0.029460508,
-0.011797594,
-0.014382084,
-0.008623894,
0.014743645,
-0.01727457,
0.014542778,
0.033343937,
0.0129090585,
0.010471871,
0.029031992,
0.0046601165,
-0.017180832,
0.017649522,
-0.033210028,
-0.024304919,
0.00046743447,
0.004656769,
-0.028362434,
0.008128422,
-0.005523845,
0.015922066,
0.014047306,
-0.027639313,
0.016136324,
-0.021224957,
0.024010314,
0.02068931,
-0.017328136,
-0.01972515,
0.000392737,
-0.0007231216,
0.025336036,
-0.008791284,
-0.025697598,
0.0051890668,
0.0100634415,
0.0027535532,
-0.015948847,
0.0015031555,
0.043494422,
0.0006570028,
0.009300146,
-0.016859446,
0.027505402,
0.02114461,
-0.010552218,
0.02667515,
-0.024626305,
-0.022041816,
0.015131988,
-0.019551065,
0.052493267,
-0.00083066913,
-0.0009951291,
0.017810216,
-0.0023601884,
-0.013792874,
-0.14216034,
-0.024371874,
0.007894077,
0.003910213,
-0.018627075,
0.0048810705,
0.0014981338,
0.018586902,
-0.01961802,
0.019015418,
-0.00840294,
-0.0037327802,
0.003254047,
-0.004003951,
0.0011784203,
0.015480158,
0.009420667,
0.004000603,
-0.018037865,
0.028951645,
-0.012768452,
0.0065650064,
-0.013900003,
-0.0058485805,
0.029326595,
-0.013766091,
-0.022148944,
0.016256845,
0.019095765,
0.013699136,
-0.0056979298,
-0.017154051,
0.018372644,
0.0026715323,
-0.009326929,
0.006524833,
0.008262333,
-0.014542778,
0.036504246,
-0.0005942318,
0.008456505,
0.013779483,
-0.0049279393,
-0.009969704,
0.0016261865,
-0.004951374,
-0.009514404,
0.012808626,
0.02068931,
-0.004077602,
-0.040468026,
-0.02771966,
-0.046011955,
-0.026340373,
0.031442396,
-0.017770043,
-0.0020572138,
0.00798112,
-0.029058773,
-0.03746841,
0.0038666916,
-0.010244222,
-0.016310409,
-0.004338729,
0.036343552,
-0.008998846,
-0.004516162,
-0.030505016,
0.02220251,
-0.03018363,
0.006133142,
0.026005594,
-0.016390756,
0.0040072985,
-0.012433673,
0.012989406,
-0.034334883,
-0.014636516,
0.005061851,
-0.018868117,
-0.028282087,
-0.017890563,
0.018868117,
-0.01750222,
0.021519562,
0.023126498,
0.016471103,
0.0011265296,
0.03157631,
-0.025777943,
0.0025443165,
0.04831523,
0.018225342,
0.0022697982,
0.0007486484,
0.029299814,
-0.010224136,
-0.0039503863,
0.036959548,
0.0072245197,
-0.017234396,
-0.02197486,
-0.06475955,
0.026809063,
-0.013833048,
-0.0064210515,
0.027090276,
-0.020528618,
0.01975193,
-0.022470333,
0.015881892,
0.006444486,
-0.021117827,
0.010458481,
-0.0068060467,
-0.005557323,
-0.013592007,
0.0016312082,
0.034147408,
-0.006488007,
0.021064263,
0.0376291,
0.003145244,
-0.023113107,
-0.0018730856,
0.0073383446,
-0.013558529,
0.004576422,
-0.015386419,
0.026849234,
-0.0042583826,
0.02362197,
-0.002974507,
-0.016832663,
-0.014382084,
0.03133527,
-0.023876403,
-0.011556554,
-0.009427362,
0.022256074,
0.010425002,
-0.0007825447,
-0.017582567,
-0.051957622,
-0.0065214853,
-0.0008327615,
0.003933647,
-0.014422257,
-0.028603476,
0.006682179,
-0.008744414,
-0.005122111,
0.021773994,
0.012319849,
-0.0052091535,
-0.030692492,
-0.04486032,
0.0253896,
-0.011663683,
-0.0046802033,
-0.015533722,
-0.022282857,
0.021117827,
0.0155471135,
0.0071977377,
0.000017798186,
0.0031954607,
-0.009480927,
-0.022697981,
0.000119892546,
-0.007565994,
-0.031094227,
-0.013913394,
0.020649137,
-0.004750507,
0.02079644,
0.015667634,
0.019711757,
-0.003287525,
-0.0037093458,
-0.024385266,
0.027773224,
0.030397888,
-0.030638928,
-0.013966959,
0.00869085,
0.031522743,
0.006069534,
-0.0022614286,
0.01310323,
0.009213104,
0.0041144276,
0.029755112,
0.05230579,
0.015681025,
0.0033260244,
0.009012237,
0.017582567,
0.015131988,
-0.009735359,
0.021465996,
0.03819153,
-0.015198944,
-0.004566379,
0.015399811,
-0.010719608,
-0.0022279508,
0.0201001,
-0.033451065,
-0.030960316,
-0.013136708,
0.013344271,
0.016002413,
-0.02442544,
-0.0068763504,
0.007257998,
-0.02785357,
-0.0026966408,
-0.0071173906,
-0.0061733155,
-0.007847208,
0.04196783,
-0.0034917397,
0.014114262,
-0.0093336245,
-0.014823992,
0.014355302,
0.0055204974,
0.020983916,
-0.02210877,
0.018935071,
-0.0004343751,
0.00875111,
0.0015073402,
-0.0014998077,
-0.011790899,
-0.007673123,
0.0019266503,
-0.024787,
0.031040663,
0.0045529874,
0.08575686,
0.006551615,
0.011355687,
-0.0129626235,
-0.013083143,
0.020716093,
0.015131988,
0.0018697379,
-0.0010353025,
-0.012734974,
-0.0014663298,
-0.024278136,
0.012721583,
-0.03570078,
-0.005028373,
0.034388445,
-0.01975193,
0.0019099113,
-0.002164343,
-0.006836177,
0.018868117,
0.005061851,
-0.003535261,
0.004077602,
-0.036236424,
0.020930352,
-0.0019065635,
0.0009917812,
0.017930737,
-0.015386419,
0.007840512,
-0.014837383,
-0.048368797,
-0.021653473,
-0.0009264995,
-0.020006362,
-0.0031067445,
-0.023447886,
0.01740848,
0.024063878,
-0.008972064,
0.0201001,
-0.0129090585,
-0.014221391,
0.017354917,
0.0017324787,
-0.015814936,
-0.011737334,
-0.01975193
] |
Podosomes (also termed invadopodia in cancer cells) are actin-rich adhesion structures with matrix degradation activity that develop in various cell types. Despite their significant physiological importance, the molecular mechanism of podosome formation is largely unknown. In this study, we investigated the molecular mechanisms of podosome formation. The expression of various phosphoinositide-binding domains revealed that the podosomes in Src-transformed NIH3T3 (NIH-src) cells are enriched with PtdIns(3,4)P2, suggesting an important role of this phosphoinositide in podosome formation. Live-cell imaging analysis revealed that Src | [
0.00478504,
-0.01283306,
0.013821239,
-0.0022631946,
-0.022774536,
0.026581345,
-0.020625744,
-0.002855107,
0.003039147,
-0.010710796,
0.04541643,
-0.0010901468,
0.01914016,
0.015863916,
-0.018132085,
-0.0017707633,
0.020678801,
-0.026846629,
-0.014975219,
0.0026544868,
-0.03735183,
0.000690979,
-0.019644197,
-0.005229389,
-0.00044559233,
0.009364486,
0.012196381,
-0.022283763,
-0.012236173,
-0.025254931,
0.011831617,
-0.00988842,
-0.000391914,
-0.017972916,
-0.010226655,
0.013303936,
0.020891028,
-0.0029993546,
-0.0036443237,
-0.023026554,
-0.0050271107,
-0.0021753197,
-0.01990948,
-0.017177068,
-0.01158623,
-0.0030142767,
-0.0036343755,
0.009457335,
-0.02185931,
0.0187555,
-0.0036575878,
0.011977523,
-0.0018685863,
-0.010810277,
-0.0005313948,
-0.027615948,
0.0050171628,
0.029128062,
0.013688597,
-0.015611898,
0.0021222632,
-0.014006936,
-0.02396831,
0.014126314,
-0.004158309,
0.02727108,
0.008820656,
0.0022797748,
0.00566379,
-0.014325276,
0.048281483,
0.03599889,
-0.013914087,
-0.027403722,
0.02378261,
-0.030719759,
-0.030507531,
-0.016367953,
-0.022456197,
0.03536221,
-0.019577878,
-0.024406025,
-0.010578155,
0.04034953,
-0.0031336541,
0.0026975954,
0.028013872,
0.022588838,
-0.010074117,
-0.007003468,
0.0077661565,
0.029950438,
0.0015187445,
0.02317246,
-0.0061147707,
0.020532895,
-0.012892748,
0.016911784,
0.010253184,
-0.005806379,
-0.004881205,
0.03793545,
-0.017097482,
-0.02528146,
-0.02480395,
0.0052923937,
0.002669409,
-0.0038897104,
0.016885256,
0.0045263893,
-0.016367953,
0.03440719,
0.009994533,
-0.038970057,
0.04090662,
-0.006045134,
0.020824706,
-0.002581534,
-0.013124871,
-0.010810277,
0.018331047,
0.020095179,
0.02688642,
-0.014762993,
0.022986762,
0.0013570877,
0.010578155,
0.0070565245,
0.0066619166,
-0.0007249684,
0.018025972,
0.011320947,
0.007832477,
-0.004672295,
-0.016938312,
-0.011917833,
-0.023278574,
-0.0152537655,
-0.026475232,
-0.03748447,
-0.0001221752,
0.038306847,
0.0021239212,
-0.0015112835,
-0.0045263893,
0.020891028,
0.029817795,
-0.0002495317,
-0.0056472095,
0.013967144,
0.037908923,
0.008144185,
-0.00031854672,
-0.010949551,
0.014205898,
0.01626184,
0.014842577,
0.035945833,
-0.011904569,
0.004967422,
-0.0011357424,
0.022814328,
0.008681382,
0.0028119986,
0.02989738,
0.020400254,
0.011917833,
0.019113632,
-0.015757803,
-0.00052890775,
0.0090660425,
0.0070565245,
-0.031038098,
0.024406025,
-0.02047984,
0.012236173,
0.01440486,
0.011446957,
-0.03223187,
-0.029711682,
0.00010756392,
-0.007912062,
0.01977684,
0.008548741,
-0.001381129,
-0.015015012,
0.044700164,
-0.008654854,
0.0014598849,
-0.022336818,
-0.009822099,
-0.0014059993,
-0.018516745,
-0.006426478,
-0.6362545,
-0.03920881,
0.027377194,
0.005126592,
-0.0016140805,
0.03485817,
0.016062878,
-0.010710796,
-0.026302798,
-0.016686294,
-0.016328162,
0.011831617,
0.012886116,
0.005604101,
-0.033425644,
-0.01581086,
-0.005879332,
-0.0098287305,
0.036476396,
-0.014537502,
-0.029234175,
-0.014855841,
-0.007374864,
0.023994837,
0.0110225035,
0.0043605873,
0.017203595,
-0.009099203,
-0.017880067,
0.036105,
-0.035680547,
0.0029164536,
-0.015306822,
0.015691483,
0.052075032,
0.0051332237,
-0.0067547653,
0.059158083,
0.018556537,
0.039898545,
-0.0113939,
-0.014285483,
0.0048281485,
0.003946083,
-0.019179953,
0.0008696304,
-0.0074080247,
-0.004781724,
0.0032795598,
0.0061114547,
0.010399089,
-0.010060853,
-0.046079636,
0.015015012,
0.020546159,
-0.006041818,
0.036662094,
-0.024618251,
0.0030175927,
0.0078722695,
0.019246273,
0.011035768,
0.0073881284,
-0.041649412,
-0.003040805,
0.00550462,
-0.03408885,
0.014895634,
-0.0043572714,
0.016500596,
0.0014557398,
0.013138135,
-0.007991647,
0.017256651,
-0.00055626506,
0.04634492,
-0.006151247,
0.0136222765,
-0.01232239,
-0.0070167324,
0.021686876,
0.0187555,
-0.032125756,
0.000102227175,
0.029950438,
0.02528146,
-0.019352386,
0.046742845,
0.007925326,
-0.000033600772,
0.018463688,
0.017177068,
0.0036211114,
-0.049475256,
-0.01626184,
0.027801646,
0.010054221,
0.017389294,
0.0010976079,
-0.0034221492,
-0.012733579,
-0.020068651,
0.010584787,
-0.023159197,
0.040986206,
0.006688445,
-0.034035794,
0.011984155,
0.02697927,
-0.058203064,
0.00027378023,
0.009311429,
0.003398937,
-0.01011391,
-0.024923326,
-0.025997723,
0.01914016,
0.021753196,
-0.0017143906,
-0.02992391,
-0.002939666,
-0.015041539,
-0.011612758,
-0.0005595811,
0.0173495,
-0.0046557146,
0.013264144,
-0.010166966,
0.00026424663,
0.0064994306,
-0.0049110493,
0.007162638,
0.009477231,
-0.01488237,
0.01766784,
0.023769347,
-0.004154993,
0.009298165,
-0.0067514493,
-0.025560006,
-0.0040953048,
-0.008754335,
0.003859866,
-0.01193773,
-0.012342286,
-0.03828032,
-0.020294141,
-0.0061877235,
0.022336818,
0.017574992,
-0.009855259,
-0.013768182,
0.012819796,
0.009105835,
0.020665538,
-0.01193773,
-0.0013562588,
-0.020970613,
0.0033309583,
-0.008203873,
0.00025947983,
0.00021326257,
-0.004781724,
-0.005086799,
-0.002201848,
-0.0090660425,
0.0034884699,
0.007726364,
0.0080646,
-0.027218023,
0.0037902293,
0.0025931401,
-0.030454475,
0.009006354,
-0.002750652,
0.02675378,
-0.012488192,
-0.014285483,
-0.017044425,
0.0052028606,
0.009337958,
-0.04072092,
-0.008588534,
0.0015262056,
0.010485306,
0.015412936,
0.04371862,
0.0059124925,
-0.0038930264,
0.03862519,
0.0010254842,
-0.00007036214,
0.0047253515,
0.0011490065,
-0.0009566764,
-0.0215675,
0.021182839,
0.010684269,
-0.012501456,
0.022031743,
0.005590837,
-0.002022782,
0.018198406,
-0.014086521,
0.016155727,
-0.008197241,
-0.004957474,
-0.031436022,
0.019206481,
0.022840856,
0.02743025,
0.023517327,
-0.014245691,
-0.007852374,
-0.004055512,
0.031701304,
-0.0025400836,
-0.01126789,
-0.015081332,
-0.0065690675,
-0.012567776,
-0.01248156,
0.005428351,
-0.02036046,
-0.020758385,
-0.005123276,
0.016049614,
0.017946387,
-0.0026511708,
-0.0073284395,
-0.010949551,
0.0063634734,
0.016911784,
0.019975802,
-0.008111024,
0.0020658905,
0.02256231,
0.006685129,
0.04586741,
-0.010339401,
0.012415239,
0.032046173,
-0.017482143,
-0.009895052,
-0.014192634,
-0.015572106,
0.021739932,
0.0068111382,
-0.009914948,
-0.0038134414,
-0.016009822,
0.013675333,
0.006930515,
0.0017724213,
-0.0015237186,
-0.028756665,
0.007547298,
0.032444097,
0.03825379,
0.00424121,
-0.009987901,
-0.018861612,
0.016805671,
-0.026607873,
-0.01251472,
-0.004516441,
0.03313383,
0.005123276,
0.004964106,
-0.0028584232,
-0.036688622,
0.00608161,
0.01386103,
-0.018092293,
-0.015678218,
0.015001747,
-0.0012335654,
0.005143172,
0.017787218,
0.0026727251,
-0.025878346,
-0.01590371,
0.013688597,
0.0027887863,
-0.015704747,
-0.027377194,
-0.03923534,
0.0076799397,
-0.005909176,
0.029234175,
-0.0035315785,
0.019737046,
-0.0006337774,
0.006151247,
-0.024976384,
-0.03859866,
-0.0027274396,
-0.010538363,
0.021143045,
-0.0055543603,
-0.0013968801,
0.004138413,
-0.016182257,
-0.020015594,
0.055656347,
-0.006930515,
0.008542109,
-0.016699558,
-0.03175436,
-0.022363348,
-0.029844325,
-0.0029579042,
-0.019816631,
-0.021050196,
-0.015572106,
-0.013529427,
0.003495102,
-0.00716927,
0.030931985,
0.029658627,
0.0054648276,
-0.017269915,
0.007865638,
0.00049118785,
0.019246273,
0.03889047,
0.010982712,
0.016752614,
-0.008435995,
-0.014113049,
-0.008913505,
-0.010757221,
0.013211087,
-0.00937775,
0.0028899254,
-0.01977684,
-0.004201418,
-0.006711657,
0.022482725,
0.030454475,
0.0011796799,
0.006164511,
0.009656297,
-0.0022930389,
-0.0042810026,
-0.033346057,
0.034141906,
0.016818935,
0.03674168,
-0.0066353884,
0.0064065815,
0.0118846735,
0.02292044,
0.0040720925,
0.0025268195,
0.002853449,
-0.0006719118,
-0.0016223707,
-0.026939478,
-0.031223796,
0.008210505,
0.027403722,
-0.005050323,
0.023795875,
-0.01193773,
0.0066022277,
0.007540666,
-0.004675611,
0.000275231,
-0.016792407,
0.008117656,
0.0014118024,
-0.008794128,
-0.017919859,
0.033850096,
-0.017243387,
0.0006992691,
-0.034672473,
0.005939021,
-0.0040024556,
0.00083937164,
-0.015598633,
-0.0018553222,
-0.009742514,
-0.010273079,
-0.017548462,
-0.008780863,
-0.026541553,
-0.0075937225,
-0.03270938,
-0.009404278,
-0.0127534745,
-0.041304544,
0.0043672193,
0.019763574,
-0.022960234,
-0.029711682,
-0.011692343,
0.011082193,
0.0076268828,
-0.0011589546,
-0.0050271107,
-0.0028119986,
0.02364997,
-0.0039195544,
0.0011680737,
-0.026674194,
-0.025148818,
0.010869966,
0.00031751045,
-0.01549252,
0.0028617391,
0.0055212,
-0.0022598787,
0.021381801,
-0.022297027,
-0.026382383,
0.010060853,
-0.015824124,
0.012077004,
0.025241667,
0.012700418,
-0.03331953,
0.010438882,
-0.009284901,
-0.032974664,
-0.003770333,
-0.01744235,
0.00018082758,
0.0026876472,
-0.0008178174,
0.0136222765,
-0.0047352994,
-0.012156588,
-0.008535476,
-0.005869384,
-0.009822099,
-0.015983295,
0.022867385,
0.043347225,
-0.010571523,
0.013337097,
-0.028597495,
0.0060119736,
-0.015081332,
0.0013388495,
0.021050196,
-0.0019448552,
-0.012740211,
0.007885533,
-0.017468877,
-0.0048977854,
-0.027191496,
-0.0023543856,
0.0064729024,
0.026316062,
0.0050105304,
-0.010312872,
0.015121125,
-0.004397064,
0.013230984,
-0.011241362,
0.0060219215,
-0.015094596,
-0.017574992,
0.0076003545,
-0.003687432,
-0.008197241,
-0.0013919062,
-0.04090662,
-0.034194965,
0.016208785,
0.008508949,
0.014617087,
-0.0042179977,
0.018105557,
-0.0010636186,
-0.011354107,
-0.015757803,
-0.039155755,
-0.009039515,
0.0059357043,
0.02772206,
0.028756665,
0.017243387,
0.009265005,
0.030719759,
0.026302798,
0.016978106,
-0.0086349575,
0.00001283021,
0.01065774,
-0.011738768,
0.031091154,
0.014590559,
0.0063336287,
0.016712822,
-0.022615366,
0.004874573,
0.004330743,
-0.015718011,
-0.009357854,
-0.00006979219,
-0.032735907,
-0.029313758,
0.011659183,
-0.013821239,
-0.019670727,
-0.039182283,
-0.0073151756,
-0.015068068,
-0.0019713833,
-0.013536059,
-0.006884091,
0.028491382,
-0.007971751,
0.023464272,
-0.019551348,
-0.0051829643,
-0.012726947,
-0.0027324138,
0.007467713,
0.0027241237,
0.0107970135,
-0.024790686,
0.0055444124,
0.04090662,
0.0046225544,
-0.0041152006,
-0.0011199912,
0.0012401975,
-0.028491382,
-0.0041914694,
-0.01565169,
-0.013496267,
-0.023477536,
-0.039765906,
-0.051517937,
-0.009039515,
0.022098064,
-0.013522795,
0.0122162765,
-0.008555373,
-0.0056737377,
0.03607847,
-0.0005604101,
-0.005895912,
-0.023689762,
0.020174764,
0.02532125,
0.00030880584,
-0.025851818,
-0.0032381092,
-0.00886708,
0.018012708,
0.042551376,
0.0227878,
-0.010697532,
-0.028730137,
0.010359297,
0.0014457917,
-0.012229541,
-0.021912366,
0.025652856,
0.0008414441,
0.024127478,
-0.006154563,
0.0063734213,
-0.022098064,
-0.0028600811,
-0.014630351,
0.008820656,
-0.0010520124,
0.009430806,
-0.013436578,
0.010624579,
-0.0040754084,
0.024658045,
0.003969295,
-0.015054803,
0.005862752,
-0.021434857,
0.008814024,
0.011844881,
-0.021580763,
0.006320365,
-0.01798618,
-0.012600937,
0.028146515,
0.026196685,
0.004582762,
-0.028385269,
-0.03191353,
0.041782055,
0.0029943807,
-0.004194786,
0.008688015,
0.0009409252,
-0.006141299,
-0.013217719,
0.0069371476,
-0.013138135,
-0.045973524,
-0.015346615,
0.02928723,
-0.0067083407,
0.010697532,
0.00033243262,
-0.012448399,
-0.0102598155,
-0.030719759,
-0.004473333,
-0.0023792558,
-0.022641893,
-0.04247179,
-0.00071377674,
0.0012302494,
0.021514442,
-0.006990204,
0.0022814327,
-0.0013927352,
0.03748447,
-0.0071427417,
0.0054814075,
0.0034884699,
0.011533174,
-0.019511556,
0.004791672,
-0.004708771,
-0.03146255,
0.014802785,
-0.015638426,
-0.025374308,
-0.0059191245,
-0.00627394,
0.008422731,
0.012010682,
-0.009662929,
0.008721175,
0.009981268,
0.01642101,
-0.0033458804,
0.0018155298,
0.009934844,
-0.022575574,
0.0023477536,
0.022376612,
-0.023079611,
-0.0074279206,
0.025387572,
-0.010339401,
0.0010014429,
-0.006336945,
-0.00641653,
-0.0139538795,
-0.013821239,
-0.0059357043,
-0.016487332,
-0.00078838755,
-0.011931098,
-0.02426012,
0.009974636,
0.013337097,
-0.008940034,
-0.015386407,
0.015585369,
0.01440486,
0.00035357234,
-0.016925048,
-0.0021288951,
-0.009908316,
-0.03408885,
-0.0008704595,
0.005335502,
-0.019763574,
0.029738212,
0.014988483,
-0.019060574,
-0.012203013,
0.010405721,
-0.025838554,
-0.0053985068,
0.009012986,
0.0029678522,
-0.0015369827,
0.008787496,
0.0040057716,
0.0060186055,
-0.0014341855,
0.017800482,
0.0036144792,
-0.015293558,
0.017813746,
-0.025878346,
0.004125149,
0.0071162134,
-0.032629795,
-0.00536203,
0.047326468,
-0.0015394697,
0.01043225,
0.026581345,
-0.0061280346,
0.0057798508,
-0.011712239,
0.010060853,
0.0131911915,
0.010472042,
0.02774859,
-0.031382967,
-0.011718871,
-0.0017210228,
-0.02115631,
-0.0065657515,
0.01283306,
-0.0038068094,
-0.0011141881,
-0.016978106,
0.035574436,
-0.02727108,
-0.0031552084,
-0.0039759274,
0.041914694,
0.0039792433,
-0.00009062105,
0.013688597,
0.013489635,
-0.01549252,
-0.023888724,
0.00039999685,
-0.038386434,
-0.013403418,
-0.00020559423,
-0.0036476396,
-0.014418125,
-0.0075804587,
0.014099785,
-0.041198432,
0.0064828503,
0.0050171628,
0.020426782,
-0.0018719024,
0.014033465,
0.01363554,
-0.013158031,
-0.0066453363,
-0.025493685,
0.0012990572,
-0.032762438,
0.004161625,
0.0021902418,
-0.0059489687,
-0.00385655,
-0.008654854,
-0.007335072,
0.005355398,
-0.006071662,
-0.020400254,
-0.026355855,
-0.012050475,
0.18707749,
-0.020373726,
0.0053089736,
0.023291837,
0.007819213,
-0.0076932036,
0.010266447,
0.001107556,
0.016792407,
-0.0016049615,
0.02317246,
0.018145349,
-0.013224352,
-0.003481838,
0.019803368,
-0.011493381,
-0.020652272,
0.009238477,
-0.019485028,
-0.008555373,
0.0031120998,
-0.024684573,
0.0020874448,
0.014285483,
0.034645945,
0.0047618276,
-0.014789521,
-0.007534034,
-0.012329022,
0.011785192,
-0.014285483,
0.0061247186,
0.00039875333,
-0.0026495128,
0.023756083,
0.011413796,
-0.0067580813,
-0.018490218,
0.006628756,
0.009835363,
0.0039162384,
-0.008011543,
-0.022283763,
-0.010790382,
-0.0173495,
-0.0019415391,
-0.0013421656,
0.007275383,
-0.0023792558,
0.006383369,
-0.021395065,
0.011413796,
0.012567776,
0.0069371476,
-0.042047337,
-0.00720243,
-0.0023693077,
0.021938894,
0.008309986,
0.033558287,
-0.018941198,
0.009841995,
-0.017137274,
0.024830477,
0.0020078598,
0.0072156945,
0.0009376092,
-0.013211087,
0.019644197,
-0.017429085,
0.004506493,
0.0007063157,
-0.019339122,
0.0015303507,
-0.005222757,
-0.023822403,
0.043161526,
0.0015776042,
0.029791268,
0.030321835,
-0.0037040124,
0.003853234,
-0.023477536,
0.009019618,
-0.0020426782,
-0.028173042,
0.017070953,
0.005524516,
-0.006356841,
0.006002025,
-0.0040190355,
-0.011765296,
-0.0014250665,
-0.0051730163,
0.017681105,
0.0014051703,
0.025838554,
0.026435439,
-0.020440046,
-0.015479256,
-0.036211114,
0.07565868,
0.027218023,
0.012474928,
-0.007547298,
-0.017031161,
-0.010014429,
0.021965424,
-0.0035514745,
-0.012521353,
0.0063269967,
-0.032205343,
0.008926769,
-0.008038071,
0.005809695,
-0.011579598,
0.0122162765,
-0.022482725,
0.033531755,
-0.018238198,
-0.007268751,
-0.022575574,
0.017389294,
0.017402558,
0.0043639033,
0.008250298,
-0.039872017,
0.017614784,
0.003859866,
-0.03255021,
0.010531731,
0.011500013,
-0.005706898,
0.030772815,
-0.004602658,
-0.008774231,
0.0009085939,
0.008024807,
-0.0070432606,
0.013821239,
-0.01907384,
0.00069263706,
0.004990634,
0.023530591,
0.008515581,
0.000831496,
0.03408885,
0.012693786,
0.0003477693,
-0.024180535,
-0.012421872,
-0.010671004,
-0.0032795598,
-0.0065989117,
0.010671004,
-0.03363787,
-0.0127601065,
-0.031568665,
-0.011108721,
-0.0011473484,
-0.02144812,
0.014842577,
0.016407747,
-0.009371118,
-0.024021365,
-0.010704164,
-0.16649154,
0.009251741,
0.02240314,
-0.0028899254,
0.023384687,
0.014935426,
0.005086799,
0.017628048,
0.013177928,
-0.009444071,
0.035839718,
0.0060915584,
-0.020665538,
-0.006804506,
0.014444653,
0.019126896,
0.019936008,
0.029313758,
0.016155727,
0.0022532465,
0.012083636,
-0.010717428,
0.009245109,
-0.028491382,
-0.00028580087,
0.02253578,
-0.011082193,
-0.03069323,
0.0050005824,
-0.008979825,
0.0061247186,
-0.007653411,
0.02532125,
0.009364486,
0.016381219,
0.017415822,
0.0028070246,
0.0031668143,
0.014285483,
0.018198406,
0.02976474,
0.018941198,
0.0036376915,
-0.02093082,
0.015068068,
0.002765574,
-0.01526703,
0.002492001,
0.027324136,
-0.012819796,
0.034380663,
0.003214897,
0.0045330212,
0.024737628,
0.03337259,
0.022761272,
0.017482143,
0.016752614,
0.0013405075,
0.01494869,
-0.007839109,
-0.017880067,
0.01046541,
-0.0139538795,
-0.0083033545,
-0.022748007,
-0.0038333377,
0.004324111,
-0.023252046,
0.008111024,
-0.023039818,
0.0035614227,
0.004572814,
-0.016726086,
0.030799342,
0.027960816,
-0.009450703,
0.0070498926,
-0.009735882,
0.023437742,
-0.0098287305,
-0.007335072,
-0.021395065,
-0.019378915,
-0.01651386,
0.01830452,
0.001837084,
0.0050072144,
-0.019551348,
0.014431389,
-0.0041118846,
-0.024512138,
0.02883625,
-0.01699137,
0.018463688,
0.030030023,
-0.008455892,
0.009198684,
-0.009225212,
-0.0022631946,
0.020493103,
-0.004599342,
-0.026859893,
0.018092293,
0.011188306,
0.016686294,
0.018609595,
-0.0061976714,
0.047512166,
-0.0026395647,
-0.023225516,
-0.0061147707,
0.004297583,
0.018450424,
-0.009948108,
0.042843185,
0.019577878,
0.00902625,
0.0026163524,
-0.037166134,
0.06738185,
-0.0074013923,
-0.010100646,
0.019126896,
0.0011415454,
-0.04088009,
-0.124576844,
-0.018782029,
0.02989738,
0.02496312,
-0.013343729,
0.0016082774,
-0.0046457667,
-0.0019746996,
-0.0143783325,
0.028411796,
-0.016049614,
-0.00937775,
0.0026196684,
0.009012986,
-0.0008654854,
-0.021673612,
0.008774231,
-0.0011440325,
-0.026435439,
0.012793267,
-0.010332769,
0.004168257,
0.0152537655,
0.0025550057,
-0.0022416404,
0.0022366664,
-0.015373143,
0.02224397,
-0.00028020504,
0.029021947,
0.025533477,
-0.0017243387,
0.00976241,
0.00058486586,
-0.017203595,
-0.002215112,
0.025692647,
-0.015001747,
0.027403722,
0.003684116,
-0.0068111382,
0.01526703,
0.01043225,
0.0021819517,
-0.006071662,
-0.020532895,
-0.012567776,
0.015227238,
0.011141881,
-0.015943501,
-0.028491382,
-0.0058130114,
-0.019962536,
-0.036555983,
0.03191353,
-0.019644197,
-0.008402836,
0.009059411,
-0.01721686,
-0.006509379,
-0.024604987,
0.015598633,
-0.0017359449,
0.0110424,
0.031197267,
-0.018025972,
-0.018967725,
-0.022416404,
0.023795875,
-0.016699558,
0.015452728,
-0.0068708267,
-0.019286066,
-0.006310417,
-0.0046225544,
-0.025069233,
-0.00457613,
-0.024671309,
-0.008104392,
-0.017747425,
-0.008455892,
-0.018092293,
0.0057267942,
-0.036476396,
0.032656323,
-0.0003859037,
0.031144211,
-0.00038092965,
0.019431971,
-0.020692065,
-0.002302987,
0.039606735,
0.010418985,
-0.016726086,
0.0040720925,
0.009311429,
-0.0036642198,
-0.014457917,
0.0074146567,
0.019206481,
-0.028703608,
-0.020294141,
-0.05952948,
0.01626184,
-0.0038101254,
-0.00606503,
0.001013049,
-0.028438326,
-0.0089532975,
-0.0077661565,
0.009424174,
0.0055112517,
-0.023371423,
-0.012169852,
-0.0013678649,
0.0024472347,
-0.03456636,
-0.016155727,
0.03504387,
-0.021023668,
0.0014217504,
0.025254931,
-0.016712822,
-0.0074080247,
0.0023162512,
0.025772233,
0.0068708267,
-0.012368814,
-0.014444653,
0.018331047,
-0.00081657385,
0.015081332,
0.006711657,
-0.05159752,
-0.007096317,
-0.0054117707,
-0.03130338,
-0.007706468,
-0.031887002,
0.018224934,
0.0043771677,
0.032974664,
-0.0024439185,
-0.055656347,
0.0018602962,
0.0036111632,
-0.016341425,
-0.01146022,
-0.024034629,
0.0047983043,
0.0040720925,
-0.008721175,
0.023039818,
0.016182257,
-0.012043843,
-0.020493103,
0.0014723201,
0.000640824,
0.0146038225,
-0.008243666,
-0.012992229,
-0.033531755,
0.021806253,
0.018410632,
0.020811442,
0.007852374,
0.0051033795,
-0.006147931,
-0.035839718,
0.0061976714,
-0.012083636,
-0.0215675,
-0.019949272,
0.023994837,
0.0034519935,
0.003876446,
-0.009656297,
0.00275231,
-0.028173042,
-0.027191496,
0.0018951147,
0.021806253,
0.02154097,
0.027642477,
-0.018609595,
0.021249158,
0.041304544,
-0.00793859,
-0.008316618,
0.047114242,
-0.002110657,
0.0025997723,
-0.012667257,
0.011864777,
0.019219745,
-0.008111024,
0.012992229,
0.004297583,
0.006522643,
0.015121125,
0.01228923,
0.0053122896,
-0.0032729276,
0.008329882,
0.004712087,
-0.006903987,
-0.015824124,
0.03178089,
-0.022442931,
-0.012329022,
-0.0010611316,
0.0009550184,
0.018556537,
0.014895634,
-0.0012692128,
-0.01023992,
-0.012209645,
0.009337958,
0.031011568,
-0.013158031,
-0.003309404,
0.03706002,
0.029393343,
0.021328744,
-0.0032729276,
-0.006250728,
0.018702444,
-0.0042179977,
0.013005493,
-0.033611342,
0.03472553,
-0.00045346792,
0.006383369,
-0.013429946,
-0.022230705,
-0.002931376,
-0.014497709,
-0.010220023,
0.010578155,
0.016845463,
-0.015824124,
0.08202547,
0.021594027,
-0.0043440075,
-0.013476371,
-0.02387546,
0.0166465,
0.02262863,
0.028411796,
-0.017800482,
-0.038651716,
0.02364997,
-0.008681382,
-0.00037305406,
-0.01904731,
-0.015890446,
0.013555955,
-0.018357575,
0.012826428,
-0.006930515,
-0.01386103,
0.007971751,
-0.01990948,
-0.0058594355,
0.02960557,
-0.028305683,
0.0019448552,
0.0043672193,
0.021620555,
0.009769042,
-0.03870477,
0.0056870016,
-0.014869106,
-0.057937782,
-0.0074279206,
-0.006237464,
-0.004954158,
-0.008382939,
-0.037086546,
-0.0004497374,
0.01975031,
-0.005497988,
0.003309404,
-0.017681105,
-0.035707075,
0.008051336,
0.0046523986,
-0.0021255792,
-0.004237894,
0.006509379
] |
Human astrocytes are larger and more complex than those of infraprimate mammals, suggesting that their role in neural processing has expanded with evolution. To assess the cell-autonomous and species-selective properties of human glia, we engrafted human glial progenitor cells (GPCs) into neonatal immunodeficient mice. Upon maturation, the recipient brains exhibited large numbers and high proportions of both human glial progenitors and astrocytes. The engrafted human glia were gap-junction-coupled to host astroglia, yet retained the size and pleomorphism of hominid astrogl | [
0.003317143,
0.0053027095,
0.0012355009,
-0.040183276,
-0.008838973,
-0.0030171168,
-0.006165706,
0.0409384,
-0.021628851,
-0.019579234,
0.004827387,
0.005481377,
0.00720737,
-0.014994565,
-0.0023951526,
0.005997152,
0.03101394,
-0.006378084,
-0.015304704,
0.01828474,
-0.02106251,
0.013598938,
-0.0031249914,
-0.017677946,
0.0013585454,
0.022909861,
0.014455193,
-0.03336021,
-0.013275314,
-0.023894217,
-0.0019703964,
-0.0046689464,
-0.009007527,
-0.016572231,
-0.0053532757,
-0.022923347,
0.020320872,
-0.00029897268,
0.014495646,
0.02056359,
0.0063578575,
0.001909717,
-0.009189565,
0.0011301547,
0.007753485,
0.01469791,
-0.03020488,
-0.024986448,
-0.018311707,
0.011353798,
0.022640176,
0.0016484583,
-0.00045636,
0.0057611763,
-0.034492895,
-0.02730575,
-0.005660044,
0.01335622,
0.0043824045,
-0.026833799,
0.003856516,
-0.004412744,
-0.020293903,
0.023314392,
0.0022181708,
0.019174704,
-0.011468415,
-0.0024170645,
0.0050869603,
-0.01082791,
0.028101325,
-0.0041733976,
-0.008420958,
-0.0030356578,
0.014738363,
-0.018082475,
-0.025701117,
-0.006260096,
-0.023381812,
0.0052791117,
0.0029075567,
-0.04196321,
-0.003819434,
0.011663938,
-0.00017719241,
0.020523136,
-0.014805784,
-0.0049689724,
0.014684426,
0.000083592255,
0.007315244,
0.019916343,
0.0069848783,
0.02514826,
0.0114819,
0.0042644166,
-0.012088694,
0.027750732,
0.0074096345,
-0.0075377356,
-0.010564966,
0.013268572,
-0.014091115,
-0.022383973,
-0.0014116399,
0.0068230666,
0.019242126,
0.01320115,
0.013126987,
0.00007885168,
0.014441708,
0.01800157,
-0.010497544,
-0.048921116,
0.0073556975,
0.0032446648,
0.043041952,
0.011165018,
0.004365549,
-0.0067050788,
0.019457875,
0.00116218,
0.012041499,
-0.0033710804,
0.028155264,
0.04724906,
0.006341002,
0.009594095,
-0.010659356,
0.003482326,
0.0002616801,
-0.012446028,
0.023085158,
0.022006413,
-0.009337893,
0.0020614157,
0.0024423476,
0.013416899,
-0.007834391,
-0.025701117,
-0.0115695475,
0.023948155,
-0.0032766901,
0.011738102,
-0.004577927,
0.035463765,
0.036461603,
0.007922038,
0.026725926,
0.022424426,
0.019309549,
0.004234077,
0.037081882,
-0.0154800005,
0.0008343424,
0.0062735802,
-0.017853241,
0.043608293,
-0.02939582,
-0.00059541705,
0.0043891463,
-0.016936308,
0.026321394,
0.007557962,
0.012742683,
0.019916343,
-0.0018119557,
0.009243502,
0.02761589,
-0.017745366,
0.00063165615,
0.033063557,
-0.022923347,
0.025633695,
-0.023112126,
0.012843816,
0.008791777,
0.011097596,
-0.033441115,
-0.01550697,
0.0069983625,
0.017367806,
0.015331673,
-0.018635333,
-0.0053532757,
-0.020914182,
0.026227005,
-0.0077062896,
0.012371865,
-0.026388817,
0.00067632296,
0.011852718,
-0.02393467,
-0.009304182,
-0.64379543,
-0.029638538,
0.028964322,
-0.04827387,
0.0011967336,
0.033036586,
0.0049824566,
-0.022235645,
-0.011576289,
-0.0013686586,
-0.02481115,
0.02882948,
0.020523136,
-0.019147737,
-0.02231655,
-0.02243791,
-0.001077903,
-0.00533642,
0.031175751,
-0.011380767,
0.004652091,
-0.011111081,
-0.015803624,
0.009344635,
0.01678798,
0.027090002,
0.029665507,
-0.021183869,
-0.03379171,
0.050161675,
-0.022788502,
0.026955158,
-0.018500488,
-0.015709234,
0.050781954,
-0.012398833,
-0.01769143,
0.03260509,
-0.01669359,
0.02106251,
-0.005700497,
-0.02234352,
-0.0048139025,
0.0062027876,
-0.03373777,
0.023300907,
-0.012459513,
-0.012587613,
-0.0053532757,
-0.0048509846,
0.004544216,
0.021197353,
-0.017650977,
0.01335622,
0.0069174566,
-0.007928781,
0.01947136,
0.0053161937,
0.014684426,
-0.008623224,
0.006155593,
0.018487005,
-0.0044262283,
-0.026132615,
0.013834913,
0.014172021,
-0.024339199,
-0.0023698695,
0.0025738198,
-0.008427701,
0.015533938,
0.007139948,
-0.03470864,
-0.0036306535,
-0.019700592,
0.019376969,
-0.0022501962,
-0.00620953,
-0.005457779,
0.0095738685,
0.0028468773,
-0.022586238,
-0.017920664,
0.011819008,
0.0059904098,
0.00022923345,
-0.009074948,
0.010693067,
-0.010254826,
-0.0034469296,
0.009897492,
0.00870413,
-0.000087384724,
-0.047437843,
-0.012682004,
0.012655036,
-0.011057143,
0.010153694,
0.013322509,
-0.011313345,
-0.0029513808,
-0.005949957,
0.017677946,
0.005053249,
0.010773973,
0.018487005,
-0.034331083,
0.00018646287,
0.031040907,
-0.03975178,
-0.00088827964,
0.0042307056,
0.015008049,
0.012210052,
0.023826795,
-0.015061987,
0.0045644427,
0.008468154,
-0.00964129,
-0.030636378,
0.0250269,
-0.00042138505,
-0.0028755316,
0.0028923869,
0.032092683,
0.0016257035,
-0.005322936,
-0.016369967,
-0.009958171,
-0.004409373,
-0.0055117165,
-0.013551743,
0.020091638,
-0.017138572,
0.030663347,
0.031876937,
0.022114286,
0.0023108756,
-0.0046959147,
-0.011852718,
-0.02611913,
0.009499704,
0.0020866988,
-0.00014464042,
-0.015709234,
-0.004999312,
-0.010173921,
-0.0076725786,
-0.009459252,
0.0043014986,
-0.0051173,
-0.0053128228,
-0.008097335,
0.00923676,
0.021129932,
-0.018298224,
-0.0017057667,
-0.027076516,
0.00973568,
-0.00948622,
-0.021615367,
0.02605171,
0.020320872,
0.02193899,
-0.008751324,
-0.019134251,
-0.025134774,
0.0010677897,
0.013275314,
-0.03416927,
-0.00042433472,
-0.010713293,
-0.0040891203,
0.013598938,
-0.012978659,
-0.016949791,
-0.01469791,
0.0007104552,
-0.006839922,
0.0014874892,
-0.0018793773,
0.00077366293,
-0.0010880162,
-0.006378084,
0.041882303,
0.016572231,
0.037027948,
0.0000831182,
-0.0052150614,
0.027885577,
-0.004544216,
0.044767946,
-0.0060746865,
0.012149373,
-0.0048914375,
-0.034627736,
-0.0023884105,
-0.013282056,
0.0014942314,
0.011562806,
0.023435751,
-0.026968643,
0.0019451133,
-0.02077934,
0.03373777,
-0.01441474,
-0.007375924,
-0.016572231,
-0.011812265,
-0.006728676,
-0.009351376,
0.00044877507,
-0.019444391,
-0.013848398,
-0.0022586237,
-0.0032244383,
-0.008131046,
-0.005599364,
-0.012176342,
-0.036650386,
0.0019670255,
0.0052015767,
0.014037179,
-0.009533416,
-0.001972082,
0.045226414,
-0.018095959,
0.026982127,
-0.005127413,
-0.021237805,
0.016302545,
0.026510175,
0.007807422,
0.030043067,
0.009553642,
0.020968119,
0.008360279,
-0.008427701,
0.010039077,
0.013113502,
0.019943312,
0.01778582,
-0.004102605,
-0.0029665506,
-0.0073691816,
-0.01607331,
0.020361325,
-0.009884007,
-0.024163904,
0.029260976,
-0.010173921,
-0.008124303,
0.00045804554,
0.011488642,
0.029962162,
0.0025249391,
-0.0024777441,
0.005673528,
0.025377493,
0.028047388,
0.008232178,
0.0002983406,
-0.009877265,
-0.011845976,
0.00085372606,
0.002224913,
0.018446552,
-0.016275575,
0.0070253313,
-0.0063848263,
-0.03311749,
-0.020671465,
0.011043659,
-0.04813903,
0.0100255925,
0.020550106,
0.0014605206,
0.001510244,
0.02780467,
0.0015279421,
-0.031337563,
-0.023152579,
0.0054510366,
0.016747527,
-0.015008049,
-0.00026294426,
-0.03039366,
-0.007827649,
0.0020074784,
-0.0138618825,
0.002496285,
-0.005326307,
-0.008131046,
0.006550009,
-0.019727562,
-0.018325193,
0.010524512,
0.007814164,
0.015372126,
-0.026388817,
0.0043824045,
-0.011293119,
-0.012041499,
0.002583933,
0.025471883,
0.009054721,
-0.007389408,
-0.011279635,
0.009668258,
-0.022801988,
-0.013834913,
-0.024339199,
0.0025384235,
-0.0015009735,
-0.006799469,
-0.01207521,
0.00059457426,
0.014037179,
0.027157422,
0.012749426,
-0.010382927,
-0.04409373,
-0.009587352,
-0.036893103,
0.031283624,
0.01429338,
-0.014873207,
0.011596517,
0.017826272,
-0.015803624,
-0.007719774,
-0.011893171,
0.021089477,
-0.0042239637,
-0.013619164,
-0.011279635,
0.015601359,
0.0005183036,
0.037000977,
0.038996655,
-0.016612684,
-0.021790663,
-0.004416115,
-0.005973554,
0.022208678,
-0.007261307,
0.024581918,
0.03036669,
0.033548992,
0.0038093207,
0.02077934,
0.016909339,
-0.008913136,
0.003313772,
-0.011468415,
0.018311707,
-0.0073287287,
-0.01676101,
-0.0005916246,
-0.019498328,
-0.00029244123,
-0.00007205684,
0.019943312,
0.03077122,
0.023139095,
0.028451918,
-0.0020496168,
-0.022896377,
0.011245924,
-0.0116437115,
0.0011697649,
-0.0024524608,
-0.013612422,
-0.02355711,
0.03238934,
-0.02087373,
-0.0020310758,
-0.0019973652,
0.0014048977,
-0.00058151135,
-0.009101917,
-0.0099109765,
-0.0010998149,
-0.015749687,
-0.01925561,
-0.019484844,
-0.01360568,
-0.011030175,
-0.011623485,
-0.020347841,
-0.005831969,
0.002474373,
-0.030906064,
-0.007908555,
0.020995088,
-0.02327394,
-0.035652544,
-0.00291767,
0.01918819,
0.024163904,
0.029314915,
-0.011562806,
0.009722196,
0.026200036,
-0.0023327875,
-0.029099165,
0.001513615,
-0.012837074,
0.01956575,
-0.0073624393,
-0.007342213,
-0.012897753,
-0.004143058,
-0.02215474,
0.017259931,
-0.027454078,
-0.021170385,
0.013551743,
-0.00002507241,
0.003332313,
0.0060847998,
-0.0023344732,
0.008636707,
-0.0045981538,
-0.008602997,
-0.029638538,
-0.00037018675,
-0.02633488,
-0.01825777,
-0.013403416,
-0.0069039725,
-0.0098368125,
-0.019835437,
-0.033495054,
0.013679844,
-0.022855924,
0.031903904,
-0.017327353,
-0.0001225177,
0.016922822,
0.0149541125,
0.0012801677,
0.018176865,
-0.035517704,
-0.0017200938,
-0.020078154,
0.045388225,
0.018217318,
-0.021817632,
-0.0031755576,
0.019619687,
-0.0034401875,
-0.016868886,
-0.019039862,
-0.009884007,
0.024662824,
0.0077602267,
-0.012230279,
0.0064522475,
-0.024406621,
-0.020172544,
0.014792301,
-0.00085709715,
0.007011847,
-0.014333833,
0.012830332,
0.0014664199,
0.00521169,
0.004884695,
-0.03737854,
-0.004534103,
0.03322537,
0.018042022,
0.0024288634,
-0.017394774,
-0.00424419,
-0.0027069775,
-0.016423903,
-0.023287423,
-0.0034620995,
0.011036917,
-0.015560906,
0.027090002,
0.036326762,
0.027278781,
0.008198467,
0.014387771,
0.023853764,
0.020536622,
-0.011387509,
0.01947136,
0.010564966,
-0.015453032,
0.016491326,
0.0025097693,
-0.009897492,
0.010976237,
-0.013106761,
0.0044700527,
0.009991882,
-0.016154217,
-0.022087319,
-0.0035126656,
-0.029719444,
-0.01947136,
0.0071534324,
0.0060578315,
-0.009189565,
-0.02802042,
-0.0038767424,
0.018163381,
0.0017091377,
-0.0052285455,
-0.008751324,
0.032632057,
-0.009877265,
0.0077602267,
0.00055327854,
0.0060207495,
0.0073354705,
-0.015250768,
-0.0044666813,
0.0026227005,
0.0081445305,
0.0077737113,
0.017893694,
0.003617169,
-0.017435227,
0.007375924,
0.0122842165,
-0.020900698,
-0.013120244,
-0.0045577004,
-0.04288014,
-0.021359164,
-0.020347841,
-0.019309549,
-0.015587876,
-0.010511029,
0.014751848,
-0.013491063,
0.031849965,
-0.006155593,
-0.010875105,
0.051698886,
-0.0059566987,
0.031957842,
-0.016949791,
0.015736204,
0.031310596,
-0.0029631795,
-0.027197875,
-0.008211952,
0.019646656,
0.010349217,
0.032308433,
0.014023694,
-0.017907178,
-0.026388817,
0.0015928354,
0.027386656,
-0.0048880666,
-0.038484253,
0.02262669,
0.02481115,
0.00024924925,
0.0021507493,
-0.021831116,
-0.017961117,
0.0071601747,
0.0040857494,
-0.008151272,
0.007638868,
-0.0055218297,
-0.01588453,
0.025930349,
0.0028923869,
0.007847875,
-0.002818223,
0.012439286,
-0.0038228051,
-0.02084676,
-0.008555802,
0.00496223,
-0.004159913,
0.015776657,
-0.0017200938,
-0.008299599,
0.011272892,
0.007922038,
0.009270471,
-0.0037452702,
0.009722196,
0.03878091,
-0.0019181446,
0.0006379769,
0.008812004,
0.03295568,
0.0115695475,
-0.008771551,
-0.004200366,
0.01167068,
-0.017893694,
-0.008400732,
0.02611913,
0.012001046,
-0.0070523,
-0.005454408,
-0.018190349,
0.0053499043,
-0.04371617,
-0.0023429007,
0.0072275964,
-0.02982732,
-0.0077871955,
0.019835437,
0.027723765,
0.007908555,
-0.0053970995,
-0.014306865,
-0.01067284,
0.028451918,
0.0010138524,
0.016518293,
0.023233486,
0.027939513,
-0.035895262,
-0.008838973,
-0.0076051573,
-0.018810628,
-0.010976237,
-0.023907702,
-0.027723765,
-0.0072815334,
-0.01441474,
0.012344896,
-0.01107737,
-0.0071534324,
-0.009115401,
0.02284244,
0.018217318,
0.002939582,
-0.011178502,
-0.007915297,
-0.0033929923,
-0.009776133,
0.009877265,
-0.016990244,
0.00003265734,
0.009863781,
-0.016275575,
0.009351376,
-0.02452798,
-0.0013762435,
-0.023206517,
-0.003741899,
0.0020732144,
0.002140636,
-0.0104773175,
-0.022505332,
-0.019606203,
0.010106498,
-0.0016973389,
-0.0149541125,
-0.01806899,
0.025471883,
0.0019771387,
0.013302282,
-0.020860245,
-0.011926882,
-0.0010627331,
-0.033548992,
-0.038888782,
0.011704391,
-0.010956011,
0.03770216,
-0.007814164,
-0.018055506,
-0.017907178,
-0.001458835,
-0.06181213,
-0.009000785,
-0.0017782449,
0.013915819,
0.0057240943,
0.012803363,
-0.006556751,
-0.032119654,
-0.0048509846,
0.017516132,
-0.001678798,
-0.02611913,
0.017165542,
-0.00030613624,
0.0073826658,
0.01669359,
-0.023786342,
-0.018513974,
0.016895855,
-0.0056195906,
-0.005875793,
0.0035463765,
0.0008048454,
0.038807876,
-0.0047869342,
0.030312754,
0.012506708,
0.01610028,
0.03039366,
-0.025647178,
-0.008380505,
0.011063886,
-0.016437387,
-0.010180662,
-0.032712962,
-0.010302021,
-0.01210892,
0.010119983,
0.0033407407,
-0.019363485,
0.01859488,
-0.0007576503,
0.0024794296,
-0.011724617,
-0.0047633364,
0.027090002,
-0.0004226492,
-0.0073961504,
-0.008589513,
0.0038362893,
-0.013888851,
0.008818746,
0.0039273086,
0.0038362893,
0.0066039464,
0.005504974,
0.018028537,
-0.047842372,
-0.0027541725,
-0.0043082405,
-0.002733946,
-0.02056359,
0.027777702,
0.0072006276,
-0.021089477,
-0.004908293,
-0.00090344955,
0.010497544,
-0.024541464,
0.0058656796,
-0.00054485083,
0.0001197787,
-0.0030508277,
0.03400746,
-0.0030255446,
-0.025067354,
0.0033120865,
-0.0030693687,
-0.009627805,
-0.0014706338,
0.17486468,
-0.013066308,
0.021534462,
0.008865941,
-0.02334136,
-0.0015877788,
0.020698434,
-0.0043891463,
0.008791777,
-0.005053249,
-0.002518197,
-0.0020698432,
-0.020671465,
-0.0046790596,
0.01918819,
-0.02512129,
-0.025053868,
-0.016396934,
-0.0091963075,
-0.01800157,
0.0003796679,
-0.01676101,
0.012742683,
-0.0005060834,
0.02512129,
-0.0031873565,
-0.014333833,
-0.006327518,
0.02137265,
0.036326762,
-0.026186552,
0.0012590985,
-0.0002816959,
0.018015053,
0.010355959,
-0.0009042923,
-0.010848137,
0.01766446,
-0.0019771387,
-0.018419582,
-0.00266821,
0.0009152483,
0.010194147,
0.020833276,
-0.010039077,
0.04846265,
0.012257248,
-0.016747527,
-0.018581394,
0.019929826,
-0.04622425,
0.004102605,
-0.00471277,
0.026510175,
0.0050869603,
0.0028991292,
0.022545785,
0.005626333,
-0.003991359,
0.044390384,
-0.026685473,
0.018635333,
-0.016289061,
0.04207108,
0.0023226743,
0.026253974,
-0.0029749784,
-0.019929826,
0.008967074,
0.004574556,
0.003984617,
0.0033896212,
-0.02918007,
-0.008131046,
-0.008171499,
-0.015210315,
0.03203875,
0.012506708,
-0.00019383711,
0.0021591769,
-0.0008705815,
0.020239966,
-0.02087373,
0.010598676,
-0.008865941,
-0.040048435,
0.03163422,
0.02196596,
-0.021925507,
-0.019579234,
0.008946847,
0.0055218297,
-0.0052925963,
-0.028128294,
0.0040216986,
-0.019430907,
0.015763171,
0.008663677,
-0.0151428925,
-0.011798781,
-0.03336021,
0.062081814,
0.012742683,
0.011293119,
-0.018338677,
0.016639652,
0.0039643906,
0.01257413,
-0.01956575,
0.0025822476,
-0.014805784,
-0.02481115,
-0.012351639,
-0.007389408,
0.0019990506,
0.022923347,
0.0054611503,
-0.031472407,
0.05067408,
0.00486784,
-0.001993994,
-0.014037179,
0.008090593,
0.024204357,
-0.023449235,
-0.02262669,
-0.027224844,
0.025539305,
0.0073556975,
-0.017853241,
-0.027858607,
-0.026645018,
-0.0015953637,
0.007517509,
0.012931464,
0.008117561,
0.004247561,
0.02056359,
-0.007598415,
0.02165582,
-0.016154217,
-0.023368329,
0.009594095,
0.00499257,
-0.00057224085,
-0.0006008951,
0.022801988,
0.0102885375,
-0.016019374,
-0.020644495,
-0.0179746,
-0.003961019,
0.009364861,
0.003944164,
0.017044183,
-0.020684948,
-0.002162548,
-0.0313915,
0.019444391,
-0.019350002,
-0.030474566,
0.023368329,
0.013754007,
-0.032227527,
-0.008265889,
-0.0071938853,
-0.17054969,
-0.0036677353,
0.022289583,
-0.02334136,
0.02049617,
-0.0010012109,
-0.0025502222,
-0.020617528,
-0.008656934,
0.0062702093,
0.049811084,
-0.012230279,
-0.030555472,
-0.008751324,
0.0077871955,
-0.0019518555,
-0.003052513,
0.033063557,
0.0048543555,
0.011218955,
0.016585715,
-0.032578122,
0.0104031535,
0.00474311,
0.008663677,
0.00014400834,
0.005949957,
-0.014643973,
-0.007686063,
-0.032470245,
-0.0035463765,
0.015304704,
0.044174638,
0.0027288895,
0.018311707,
-0.014225959,
-0.004999312,
-0.009594095,
-0.005417326,
-0.0069983625,
0.01740826,
0.0071129794,
-0.000102870625,
0.0023142467,
0.0015464831,
-0.0018793773,
-0.014252927,
-0.029449757,
0.016369967,
-0.0075916727,
0.021359164,
-0.010996464,
-0.008097335,
0.03098697,
0.026820315,
0.031742092,
0.023300907,
0.010996464,
0.0080299135,
0.0040149568,
0.0057342076,
0.0019653398,
0.02552582,
0.005167866,
0.007975976,
-0.026591081,
0.013180924,
-0.0068567772,
-0.03077122,
0.00789507,
-0.015978921,
-0.014252927,
0.020334356,
-0.02939582,
0.025701117,
0.023718921,
-0.025512336,
-0.00583534,
-0.0045105056,
0.0003128784,
-0.034061395,
0.016814949,
-0.01828474,
-0.020536622,
-0.03236237,
-0.020280419,
0.010012109,
-0.003961019,
-0.0051038153,
0.00086215377,
0.01469791,
-0.021359164,
-0.025242649,
-0.013996725,
0.03495136,
0.025647178,
0.003189042,
-0.021736726,
0.004665575,
-0.0038767424,
0.024581918,
-0.0008238077,
-0.023098642,
0.0031856708,
0.031876937,
0.0028047387,
-0.024986448,
0.003961019,
0.031822998,
0.0049420036,
-0.0056903837,
-0.0027255183,
0.00080442405,
0.033306275,
-0.00808385,
0.036704324,
-0.0084074745,
-0.010591934,
0.010571708,
-0.021075994,
0.058252268,
-0.00071677595,
-0.017435227,
0.018999409,
0.0042644166,
0.012344896,
-0.13894245,
-0.01825777,
-0.002181089,
0.02721136,
-0.0009177766,
0.017529618,
0.00839399,
0.028505854,
-0.036893103,
0.029962162,
-0.025647178,
-0.008373763,
0.022276098,
-0.027197875,
0.022464879,
-0.0099109765,
-0.00033942563,
0.013423642,
-0.028694635,
0.022235645,
0.018500488,
0.004577927,
-0.00964129,
-0.02602474,
0.010113241,
0.015035018,
-0.041208085,
0.03654251,
0.029045228,
0.014590035,
0.014549582,
-0.018810628,
0.013383189,
0.0032025264,
-0.012297701,
-0.0142394435,
0.0021018686,
-0.028640699,
0.026348364,
-0.013733781,
-0.011697649,
0.020105124,
0.015520453,
0.005043136,
-0.023745889,
-0.0110032065,
-0.016423903,
-0.012439286,
-0.000008276265,
-0.032011777,
-0.024959479,
-0.031742092,
-0.018554427,
-0.005751063,
0.035841327,
-0.011036917,
0.0053060804,
0.010173921,
-0.021952474,
0.0021827745,
0.0030120602,
0.0008246505,
-0.015898015,
0.0043453225,
0.017192509,
0.00074163766,
-0.025552789,
-0.030852128,
0.021197353,
-0.016140733,
0.012378607,
0.015439548,
-0.0145765515,
-0.023044705,
-0.011771812,
0.011812265,
0.015533938,
-0.015223798,
-0.005248772,
0.009958171,
-0.02533704,
-0.023327876,
0.036488574,
-0.0059769256,
-0.0037857231,
-0.0014057405,
0.014401255,
-0.00474311,
0.019619687,
-0.017367806,
-0.0043958887,
0.035625577,
0.011225698,
-0.025107807,
0.0024979706,
0.0029041858,
-0.013875366,
0.0031435324,
0.012634809,
0.009749164,
-0.022262614,
-0.01441474,
-0.05024258,
0.018675786,
-0.003610427,
0.0022198565,
0.024824636,
-0.015129409,
0.005842082,
-0.032119654,
-0.0030289157,
0.0055959933,
-0.009256987,
-0.0030086893,
-0.0109290425,
0.013875366,
-0.010632387,
-0.018621847,
0.027238328,
-0.004031812,
-0.0119066555,
0.022235645,
0.011677423,
0.0032901743,
-0.00093716034,
0.013942788,
-0.01569575,
-0.00065146125,
-0.020374808,
-0.0006860148,
-0.012499966,
-0.01918819,
-0.0075916727,
-0.039643906,
-0.015844077,
-0.01491366,
-0.0024187502,
-0.025849443,
0.00964129,
0.0064623607,
0.011232439,
0.04530732,
-0.03554467,
-0.030123973,
0.025107807,
0.00094727357,
-0.012014531,
-0.012102178,
-0.024002092,
0.004699286,
0.0072815334,
-0.01226399,
0.039859653,
0.014563067,
0.003654251,
-0.008313084,
-0.022006413,
-0.014536099,
0.0022636803,
0.0010897017,
0.005936472,
-0.0002505134,
0.0341423,
0.0041632843,
0.0007209898,
0.014387771,
-0.02562021,
-0.009991882,
-0.01859488,
0.012183084,
0.0012540419,
-0.0018304966,
-0.031742092,
0.011711133,
0.031957842,
0.004200366,
0.021143416,
0.007942265,
0.011414478,
0.003991359,
-0.022235645,
0.030825159,
0.022397457,
-0.014927143,
-0.010875105,
0.029584602,
0.022734566,
0.0009868838,
-0.0072950176,
0.034519862,
0.002727204,
0.010268311,
0.0026412415,
0.009931203,
0.01916122,
0.012776394,
0.019242126,
0.027063033,
-0.014482161,
0.019821953,
0.013727039,
0.025633695,
-0.013929304,
0.0005490647,
0.01956575,
-0.011556063,
-0.028424948,
0.01619467,
-0.047222093,
-0.016235122,
-0.011819008,
0.0069579096,
0.009371603,
0.012675262,
-0.0022131142,
-0.006752274,
-0.0102346,
0.030528503,
0.018433068,
-0.017624008,
-0.0074972827,
0.02818223,
0.02552582,
0.012499966,
0.0118324915,
-0.007557962,
0.0211569,
0.011050401,
0.030744253,
-0.02103554,
0.025269618,
-0.0068567772,
0.011852718,
-0.024959479,
-0.023449235,
-0.0031013938,
-0.012344896,
-0.010227858,
-0.013403416,
0.02980035,
-0.015951952,
0.070873596,
0.0046689464,
-0.019309549,
0.0021574914,
-0.016626168,
0.0033862502,
0.0010087958,
0.020145576,
-0.0186623,
-0.014279896,
0.028937353,
-0.008886168,
0.043824043,
-0.023152579,
-0.019350002,
0.019862406,
-0.00464872,
0.0072006276,
-0.001366973,
-0.006172448,
0.029719444,
-0.022613207,
0.007308502,
0.004945375,
-0.020981604,
0.0077400003,
0.0254584,
-0.015547423,
0.00929744,
-0.00034553572,
0.023948155,
0.0055690245,
-0.057551082,
0.0030508277,
-0.017394774,
0.0039643906,
-0.0017951003,
-0.044821884,
-0.0040621515,
0.009054721,
0.0013703442,
0.012048241,
-0.015439548,
-0.0020799565,
0.009708711,
-0.01117176,
-0.03994056,
-0.017017214,
-0.01488669
] |
Since the initial discovery that OCT4, SOX2, KLF4, and c-MYC overexpression sufficed for the induction of pluripotency in somatic cells, methodologies replacing the original factors have enhanced our understanding of the reprogramming process. However, unlike in mouse, OCT4 has not been replaced successfully during reprogramming of human cells. Here we report on a strategy to accomplish this replacement. Through a combination of transcriptome and bioinformatic analysis we have identified factors previously characterized as being lineage specifiers that are able to replace OCT4 and SOX2 in the reprogramming of human fibroblasts. Our | [
-0.011367442,
-0.0062978165,
-0.015512587,
-0.014497994,
-0.022788284,
0.011687839,
-0.022120789,
0.020305201,
-0.028381893,
0.0060942303,
0.0010688265,
-0.0065648146,
-0.0073224213,
0.003188958,
-0.03444275,
-0.0022194213,
0.028515391,
-0.0049227765,
0.0060107936,
0.015459187,
-0.023816226,
0.020211753,
-0.0066616014,
-0.035163645,
-0.0150052905,
0.007869768,
0.014230996,
-0.03972931,
-0.0075026453,
-0.012755832,
0.007088798,
0.021867141,
-0.02189384,
-0.0062544295,
-0.03454955,
-0.01027275,
-0.026606355,
-0.014377845,
0.0004584857,
-0.024416972,
0.03009068,
0.034816545,
-0.0028335168,
-0.00038944167,
-0.00821019,
0.0059540565,
-0.004856027,
-0.020558849,
-0.005149725,
0.011801314,
0.017074525,
0.008877685,
-0.0017171312,
0.0060374932,
-0.018489614,
-0.025698563,
-0.005657021,
0.01229526,
0.011961512,
-0.018142518,
-0.005216474,
0.0037146104,
-0.013476727,
0.01771532,
-0.009371632,
0.020371951,
-0.01910371,
0.009952352,
0.0124020595,
-0.015178839,
0.025792012,
0.0071288478,
-0.0013600213,
-0.0039749336,
0.027741097,
-0.022975182,
-0.030411078,
0.00583057,
0.006708326,
-0.0034542873,
0.008403763,
-0.019998154,
-0.009138009,
0.02071905,
-0.0036578733,
-0.0010538079,
0.015939783,
0.022294337,
0.010993645,
0.002151003,
0.025431564,
0.036471933,
0.04381438,
0.00819684,
-0.029690184,
0.025298065,
-0.00083270017,
0.039302114,
-0.0038113971,
-0.030491177,
-0.012969431,
0.002227765,
-0.007642819,
-0.014030747,
-0.031051874,
0.012115036,
0.027580898,
0.0026516244,
0.021119546,
0.0036044738,
-0.016820878,
0.026766555,
-0.003175608,
-0.034496147,
0.029236287,
-0.037593324,
0.0018039056,
-0.01166114,
-0.031719368,
0.013897249,
0.020171702,
0.024096575,
-0.015205539,
-0.03153247,
0.0055869343,
0.01770197,
-0.0046624537,
0.012662383,
-0.027901296,
0.005503497,
0.029209586,
-0.0029887094,
0.014604793,
0.040850703,
-0.011387466,
-0.0018155867,
-0.011200569,
0.0035210368,
-0.025858762,
-0.030945074,
-0.014724943,
0.00045765133,
0.0012932718,
-0.0050629503,
-0.007269022,
-0.0017421623,
0.010599823,
-0.020678999,
0.032547064,
0.01763522,
0.0025364815,
-0.009318232,
0.027794497,
-0.02479077,
0.011901438,
0.0053900233,
0.030891674,
0.025084468,
-0.011561016,
-0.009318232,
-0.017461672,
-0.0016820877,
0.008717487,
0.022534635,
-0.0033474881,
0.021586793,
0.0099790525,
0.017007776,
0.007849743,
-0.0062210546,
-0.02452377,
0.014991941,
-0.037753526,
0.017154625,
-0.000762196,
0.00583057,
-0.01913041,
0.004856027,
-0.033348057,
-0.019744506,
-0.020892598,
0.022654785,
0.0038013847,
-0.0011505947,
-0.008824285,
-0.0018255991,
-0.0012790875,
-0.026512906,
0.008103391,
-0.013536802,
0.0028018109,
0.011574365,
0.0007413368,
-0.013203054,
-0.62498903,
-0.021533392,
0.010513049,
-0.021600142,
0.019984804,
0.023749476,
0.00012150497,
-0.012462134,
-0.020078253,
0.023442429,
-0.023642678,
0.01631358,
0.020371951,
-0.017328173,
-0.0007701225,
-0.034843247,
-0.0077562933,
-0.021186296,
0.009271507,
0.010699946,
-0.006231067,
-0.0015652761,
-0.014177596,
0.034683045,
0.010379549,
0.014511344,
0.02872899,
-0.018502966,
-0.015379088,
0.037486527,
-0.0027350613,
0.009191408,
-0.008216865,
-0.020865897,
0.04805965,
-0.0009445056,
-0.03179947,
0.013616901,
0.030464478,
0.033428155,
-0.006968649,
-0.013623576,
0.016366981,
0.013470052,
-0.028568791,
0.016140033,
0.0138038,
0.012235186,
-0.01791557,
0.013590201,
0.0062911417,
0.0073824963,
-0.032974258,
-0.005964069,
0.0047392156,
0.0113540925,
0.027847897,
-0.013029505,
0.030597977,
-0.019878006,
-0.019117061,
0.01775537,
-0.01174124,
-0.027847897,
-0.0033641753,
0.026726505,
-0.011814664,
-0.0058339075,
0.019384058,
-0.024296822,
0.017475022,
0.033801954,
-0.002004154,
0.003501012,
-0.015913084,
0.031078573,
0.009171383,
-0.005640334,
0.021787042,
-0.0069285994,
0.027046902,
-0.009064584,
-0.022948483,
0.006538115,
0.024323523,
0.0023061957,
-0.035003446,
0.036685534,
-0.003634511,
0.005193112,
0.006347879,
-0.0033942128,
-0.01096027,
-0.045710064,
-0.015565987,
0.010926895,
-0.008630712,
-0.0048126397,
-0.0110270195,
-0.03406895,
-0.013256453,
-0.0077829934,
0.030517878,
0.008850985,
0.0153657375,
0.012535558,
-0.033267956,
0.0041384697,
0.040850703,
-0.03956911,
0.006191017,
-0.013136304,
-0.0030020594,
-0.016153382,
0.0051196874,
-0.022054039,
0.019036962,
-0.0008372892,
-0.0056102965,
-0.018636463,
0.025484964,
-0.022774933,
-0.007289047,
0.026566306,
0.01652718,
0.014818392,
-0.000103201004,
-0.0032440263,
0.010733321,
-0.004976176,
-0.009778803,
-0.036178235,
0.013950648,
-0.035083544,
0.0029236285,
-0.00079765666,
0.02461722,
0.0036478608,
0.0274207,
-0.024376921,
-0.020278502,
-0.008016616,
-0.003118871,
-0.01914376,
0.0015427481,
-0.00891106,
-0.010766696,
-0.0029653471,
0.018863412,
-0.0036244986,
0.01918381,
-0.010432948,
0.005753808,
0.0040483577,
0.015512587,
-0.012722457,
-0.0010170958,
-0.028942589,
-0.0018122493,
-0.0055402094,
-0.018796662,
0.03022418,
-0.009952352,
0.002775111,
0.011754589,
-0.019317308,
-0.0052898987,
-0.0042919936,
-0.009491781,
-0.017074525,
0.013323203,
0.00009902916,
-0.021600142,
-0.00024092403,
-0.01778207,
0.008383739,
-0.008110066,
0.000714637,
0.001266572,
-0.010646547,
-0.01770197,
-0.029796982,
-0.014658193,
-0.0127625065,
0.0081834905,
0.019517558,
0.024256773,
-0.0016228475,
0.0025381502,
0.019117061,
-0.007776318,
-0.020839198,
-0.005346636,
0.019544257,
0.036391836,
-0.015792934,
-0.0020358602,
-0.0011222261,
0.00450893,
0.020145003,
0.025391515,
-0.021319794,
0.013443352,
-0.024924267,
0.010646547,
-0.029449886,
-0.0011898101,
-0.021666892,
0.0001287014,
0.011874738,
-0.010826771,
-0.004722528,
-0.011721214,
-0.035884537,
0.011507616,
-0.009198083,
-0.009011184,
-0.011394142,
0.0046924907,
-0.014925191,
-0.0017655246,
-0.008163465,
0.020104954,
0.0003998713,
0.006404616,
0.013109604,
-0.0041084327,
0.012081662,
0.030624676,
0.006614877,
-0.0045222794,
0.008450489,
0.0014793361,
0.00222109,
0.021813741,
0.0207324,
0.010806746,
-0.020198403,
0.031986367,
0.001336659,
-0.0012298598,
0.022574686,
0.0042252443,
0.0043687555,
-0.014751642,
-0.004448855,
0.033775255,
-0.016714077,
0.0017571809,
0.025044417,
-0.024804119,
0.018302716,
-0.0041518197,
0.0016620628,
0.013590201,
-0.027847897,
-0.0055769216,
0.019557606,
0.024977667,
0.036445234,
0.01619343,
-0.017101225,
-0.0029036037,
-0.0205722,
0.0011213918,
0.013029505,
0.008270265,
-0.016019883,
-0.011587716,
-0.00042239926,
-0.029983882,
0.024804119,
0.022614734,
-0.02864889,
0.012301935,
-0.007709569,
0.0205188,
0.015606036,
0.00479929,
-0.00327907,
-0.013303177,
-0.019931404,
0.022948483,
0.03967591,
-0.000010416575,
0.0063545536,
-0.033107758,
-0.014097497,
-0.009491781,
0.002037529,
0.013470052,
-0.016500479,
-0.0034843246,
0.0061209304,
-0.008530588,
-0.008477188,
0.01927726,
-0.026633056,
0.022467885,
-0.0027884608,
0.027767798,
-0.00445553,
0.0019073674,
-0.018249316,
0.0683515,
0.005293236,
-0.004642429,
-0.018609764,
-0.0136302505,
-0.026259258,
-0.007542695,
-0.017408272,
-0.01788887,
-0.01302283,
-0.009778803,
-0.0007246494,
0.006077543,
0.005163075,
0.0052999114,
0.0070620985,
0.019450808,
-0.003944896,
-0.008016616,
0.005349973,
0.035243742,
0.04392118,
0.0044388426,
0.0071822475,
-0.011020345,
0.00097203976,
-0.02471067,
-0.021266395,
0.025471615,
-0.020852547,
0.005900657,
0.017434973,
0.0013116279,
-0.004145145,
0.004285319,
0.006287804,
-0.005556897,
-0.023842925,
-0.033134457,
-0.011894763,
-0.018342767,
-0.00959858,
0.005570247,
0.025097817,
0.021867141,
0.009031209,
0.0032473637,
0.0408774,
-0.019958105,
0.0012649032,
-0.018409515,
0.021746991,
0.0032740636,
0.0073824963,
0.016847577,
-0.024390273,
0.011480916,
0.004829327,
-0.010533073,
0.02583206,
0.011807988,
0.035163645,
0.01511209,
-0.006631564,
0.010466323,
0.000166248,
-0.02177369,
0.003964921,
-0.00035335522,
-0.041651696,
-0.0072156223,
-0.036258336,
-0.01504534,
-0.0010262737,
-0.0043821055,
-0.008276939,
-0.0021977278,
-0.01160774,
-0.005186437,
0.011854714,
-0.009224783,
-0.01917046,
0.022801634,
-0.008503888,
0.014177596,
-0.0041484823,
0.012081662,
-0.010125901,
-0.033775255,
0.004729203,
0.022000639,
-0.008076691,
-0.052652016,
0.028942589,
-0.00050646195,
0.03262716,
0.020118304,
-0.029236287,
0.007389171,
0.018436216,
-0.0003921534,
-0.026966803,
0.008644062,
-0.012175111,
0.012115036,
-0.026392758,
-0.008036641,
-0.01170119,
0.0118346885,
0.019851305,
0.03268056,
0.0005373336,
-0.011641115,
-0.004639091,
-0.00310719,
0.022174189,
0.016019883,
0.028942589,
0.0023395703,
-0.024203373,
-0.011073744,
-0.017021125,
0.0033441505,
-0.029663483,
-0.039382212,
0.0036411858,
0.0063545536,
0.0007818037,
-0.03553744,
-0.027874596,
0.029262986,
0.0010596485,
0.0064880527,
-0.0007359134,
0.021666892,
0.024376921,
-0.020051554,
0.030811574,
0.015285638,
-0.0049361265,
-0.0063879285,
-0.016019883,
0.032360163,
0.013843849,
-0.0128826555,
-0.0038981715,
0.034709748,
-0.028408593,
-0.038768116,
-0.009324907,
-0.016887628,
0.029449886,
-0.026366057,
-0.018222617,
-0.023615977,
-0.009104634,
-0.027447399,
0.025658512,
0.009064584,
0.0073824963,
-0.0074492455,
0.0070420736,
0.0102594,
-0.039088514,
0.01631358,
-0.04255949,
-0.012168436,
0.041411396,
0.020358602,
0.006137618,
-0.006511415,
0.015272289,
-0.016113332,
-0.0204654,
-0.0075627198,
-0.021279745,
-0.0007171401,
-0.028995989,
0.055161797,
0.026205858,
0.038741417,
0.01788887,
0.0037513226,
-0.0064413277,
0.018382816,
-0.0048593646,
-0.018262666,
0.021279745,
-0.023829576,
0.0065314397,
-0.0028168294,
-0.0049895262,
0.022361087,
-0.012822581,
0.009818853,
0.040850703,
-0.016954375,
-0.01926391,
0.013243103,
-0.032600462,
-0.015178839,
0.0015218889,
-0.00092698383,
0.000008115541,
-0.0272872,
0.017581822,
0.022908432,
0.020358602,
0.007022049,
0.00012484245,
0.03153247,
-0.0032490324,
0.009238132,
-0.003557749,
-0.008490538,
-0.023242181,
0.006077543,
-0.018222617,
0.0038414344,
0.009665329,
-0.0016737441,
0.010152601,
0.008383739,
-0.01371035,
0.0020124977,
0.045389667,
-0.0085439375,
-0.014431245,
0.0013099592,
-0.033241257,
-0.004639091,
-0.017141275,
-0.008216865,
-0.020692348,
-0.030731475,
0.017381573,
-0.021746991,
0.014791692,
-0.010833446,
-0.010152601,
0.02583206,
-0.005944044,
0.027233802,
0.021626841,
0.03302766,
0.018850062,
0.0017046157,
-0.023669377,
-0.029289685,
-0.008490538,
-0.015726184,
0.040183205,
0.017007776,
-0.0019424108,
-0.022801634,
0.008190165,
-0.00954518,
-0.014738292,
-0.023749476,
0.005887307,
0.0037246228,
-0.0062544295,
-0.00032602964,
-0.0011297355,
-0.025418214,
0.004996201,
-0.002806817,
0.006414628,
-0.00029182053,
-0.010419599,
-0.0273406,
0.01775537,
-0.0048793894,
-0.0025047755,
0.031612568,
-0.01909036,
-0.022694834,
-0.010372874,
-0.002831848,
0.000554021,
-0.0136703,
0.025484964,
-0.0274207,
-0.006458015,
0.00688855,
0.0038080597,
-0.01160774,
-0.0073424466,
0.016647328,
0.03818072,
0.005964069,
0.0081234155,
-0.0019641044,
0.0026783242,
0.0075894194,
-0.024550471,
-0.0024413634,
-0.009498456,
-0.027300552,
0.00032310936,
0.039141916,
0.018409515,
0.015339038,
0.018516315,
-0.008704136,
-0.013309853,
-0.024950968,
-0.026432807,
0.014991941,
-0.028194994,
0.013576851,
0.006614877,
0.03142567,
0.028248394,
0.0021176282,
0.0022961833,
0.012108361,
0.026179159,
-0.021466643,
0.01166114,
0.010766696,
0.006294479,
-0.03970261,
-0.013697,
-0.00055860996,
-0.028995989,
-0.005660359,
-0.021119546,
-0.035003446,
0.0026165808,
0.009384981,
0.015579336,
0.012809232,
-0.0073023965,
0.026526256,
0.0058072074,
0.0065180897,
-0.015873034,
-0.03332136,
-0.0127625065,
-0.026673105,
-0.0064379903,
0.011087094,
-0.00888436,
-0.00075301796,
-0.0042486065,
-0.01371035,
0.020225102,
-0.022881733,
-0.009491781,
0.013516776,
-0.0008477188,
-0.017675271,
-0.0006070034,
-0.0047959527,
-0.0273673,
-0.013276478,
0.0015869697,
-0.0074625956,
-0.002080916,
-0.019717805,
-0.009892277,
-0.00891106,
-0.011387466,
-0.013136304,
-0.0073023965,
-0.0038180721,
-0.02334898,
-0.028969288,
0.008043316,
-0.022200888,
0.025204616,
0.018436216,
-0.013122954,
-0.027527498,
-0.002781786,
-0.05596279,
-0.020358602,
-0.006281129,
0.0056803836,
0.006237742,
-0.012635683,
-0.00752267,
-0.0106665725,
-0.026312659,
0.016674029,
-0.0031355585,
-0.03964921,
0.012675732,
0.0090512335,
0.01778207,
0.0048526893,
-0.038955014,
-0.003888159,
0.01779542,
-0.0018756613,
0.0014534707,
0.023015233,
0.0047892774,
0.03855452,
-0.005373336,
0.03414905,
0.03308106,
0.018543014,
0.033561654,
-0.036445234,
0.011280668,
0.02334898,
-0.0018756613,
0.0019273922,
-0.011460891,
-0.011227268,
0.0048593646,
0.012215161,
0.0054567726,
-0.018876763,
0.011774614,
-0.021600142,
0.012408734,
0.0025298065,
0.016754128,
0.014204296,
0.0022494586,
-0.0046691285,
-0.0071755727,
0.024497071,
0.000097516866,
0.0024647256,
0.025858762,
-0.0030504528,
-0.0130895795,
-0.0012907687,
-0.0022761584,
-0.025671862,
-0.0017688621,
0.010760021,
-0.012048287,
-0.0025515002,
0.007789668,
-0.007155548,
-0.009411681,
-0.02185379,
-0.0038347596,
-0.0083637135,
-0.0132698035,
-0.007903142,
-0.009631955,
-0.012649032,
-0.0069152494,
0.0083036395,
-0.009665329,
-0.010619847,
0.009077934,
0.008657412,
-0.005753808,
0.025378164,
0.18518984,
-0.017074525,
-0.005717096,
0.010479674,
0.009992402,
-0.0069019,
0.023469128,
-0.0037312978,
-0.013016155,
-0.010533073,
0.021199645,
0.0014125865,
-0.012502184,
-0.013950648,
0.024964318,
-0.0030404404,
-0.007122173,
-0.010092527,
-0.037967123,
0.0025665187,
0.012829256,
-0.016180081,
0.0074158707,
-0.0001852299,
0.0273673,
-0.005620309,
-0.0034609623,
0.01222851,
0.013950648,
0.020225102,
-0.040530305,
0.009905628,
0.0020592224,
0.006771738,
0.0049661635,
0.00752267,
0.01174124,
-0.015859684,
0.018155867,
-0.01803572,
0.006454678,
-0.004639091,
-0.0012306941,
-0.00024634742,
-0.0027417361,
0.037459828,
0.0082435645,
-0.005740458,
0.0062210546,
-0.0021026097,
-0.018716563,
0.020825848,
0.018649815,
0.016180081,
-0.0009962365,
-0.011961512,
0.023909675,
0.02334898,
0.0040016333,
0.03820742,
-0.009264832,
-0.0035410617,
-0.0061442927,
0.0059774187,
-0.026472857,
0.012408734,
-0.00323902,
0.0007208947,
0.033561654,
-0.022588035,
0.0018022369,
0.01638033,
-0.019931404,
0.011494266,
0.003931546,
-0.03420245,
0.045923665,
0.014578094,
0.019918054,
0.021787042,
0.010686597,
-0.016927676,
-0.027741097,
-0.006104243,
-0.004972839,
-0.01778207,
0.032093167,
0.0032056454,
-0.02452377,
-0.0136302505,
-0.0013608556,
-0.010079176,
-0.0019891355,
-0.022160837,
0.0025898812,
0.0082435645,
-0.007983242,
0.012775857,
-0.0015235576,
0.0061843423,
-0.04215899,
0.056977384,
-0.0029820346,
0.024016475,
0.009024534,
0.017928919,
0.006334529,
-0.0046924907,
-0.008096715,
0.0041017574,
0.024190024,
-0.014190947,
-0.009158033,
-0.0026516244,
0.017475022,
0.024016475,
0.025418214,
-0.023976425,
0.04226579,
0.0060675307,
-0.010639872,
-0.020278502,
-0.010306125,
0.031185372,
-0.01643373,
-0.013790449,
0.012008238,
-0.004672466,
-0.036098137,
-0.03676563,
0.0020124977,
0.012715782,
0.0029052726,
0.019117061,
0.01915711,
-0.026512906,
0.004932789,
-0.008624037,
-0.025645163,
0.016153382,
-0.011107119,
-0.0061709923,
-0.006471365,
0.006825138,
-0.0042419317,
-0.0025214627,
0.012909356,
0.016687378,
-0.015712835,
-0.023509178,
-0.019797906,
-0.008764211,
-0.0034075626,
0.014698243,
0.026486207,
-0.019330658,
-0.008256915,
-0.023589278,
-0.0068318127,
0.016073283,
-0.0274207,
0.038768116,
-0.006377916,
-0.01646043,
-0.0120416125,
-0.018396165,
-0.16746117,
-0.017341522,
0.015192189,
-0.028995989,
0.026993504,
0.008036641,
0.0073624714,
-0.0071822475,
-0.0061843423,
0.0048593646,
0.022321036,
0.03276066,
-0.034362648,
-0.021560093,
0.000610758,
0.0065714894,
-0.017021125,
0.04237259,
0.014444594,
0.011087094,
0.01929061,
-0.0065314397,
0.010392899,
-0.01778207,
0.0021943902,
-0.017875519,
0.01163444,
-0.016086632,
-0.011561016,
-0.040717203,
-0.0039816084,
0.014417895,
0.015646085,
0.005713758,
0.0007805521,
-0.009511805,
0.0034709747,
0.007102148,
-0.00037400587,
0.017301474,
0.019450808,
0.0047892774,
-0.010699946,
0.002144328,
-0.00950513,
0.024230072,
-0.0051397122,
-0.013276478,
0.029343085,
0.008009941,
0.0075026453,
-0.0203853,
-0.009905628,
0.008049991,
0.033668455,
-0.00071505416,
0.029636784,
0.0003245695,
-0.018369466,
-0.0021426594,
-0.01508539,
-0.008704136,
0.03150577,
0.005296574,
-0.010646547,
-0.029930482,
0.004295331,
0.02322883,
-0.041357998,
-0.007008699,
-0.009338257,
0.0010621516,
0.012855956,
0.001368365,
0.020318551,
0.009358281,
-0.013283153,
0.016487129,
0.0077696433,
-0.0035744363,
-0.03030428,
0.027527498,
-0.02190719,
-0.0060541807,
-0.021359844,
0.010452974,
0.01302283,
0.024323523,
-0.023108682,
-0.024844168,
0.020091603,
-0.010780047,
-0.0106665725,
-0.018636463,
0.03831422,
0.021867141,
-0.0020592224,
-0.006377916,
-0.009191408,
-0.013516776,
0.019851305,
-0.00688855,
0.0020892597,
0.0021543405,
0.075720645,
-0.0064747026,
-0.024804119,
0.023015233,
0.063225135,
-0.010472999,
-0.022588035,
0.0024396947,
0.00030183294,
0.006721676,
-0.009952352,
0.029449886,
-0.0048360024,
0.01647378,
0.022054039,
-0.009425031,
0.066001914,
0.0043120184,
-0.012715782,
0.02341573,
-0.019984804,
-0.00010554767,
-0.13232423,
-0.016900977,
0.002182709,
0.020211753,
-0.024029825,
0.01666068,
-0.01294273,
0.038741417,
-0.009538505,
0.03179947,
0.012001562,
-0.027247151,
0.02045205,
-0.0073357713,
0.018956862,
-0.003118871,
-0.000028603208,
0.003501012,
-0.014004048,
0.022855032,
0.015926434,
-0.0074425708,
-0.014805042,
-0.021253046,
0.0055869343,
0.018249316,
-0.03695253,
0.03281406,
0.020118304,
0.020225102,
0.016847577,
-0.0204387,
0.03289416,
-0.0020525474,
-0.00011629017,
-0.0025114503,
0.00059490505,
-0.018235967,
0.039382212,
-0.024350222,
-0.0050829756,
-0.006154305,
0.0036712233,
-0.0069019,
0.020358602,
-0.00074467424,
-0.03011738,
0.012729132,
0.014751642,
-0.020812498,
-0.05080973,
-0.022601385,
-0.022000639,
-0.010719972,
0.009324907,
-0.013923949,
0.011347417,
0.012014912,
-0.024764068,
-0.012602308,
-0.004385443,
-0.01626018,
-0.0075159953,
-0.016206782,
0.00095952424,
-0.026753204,
-0.00757607,
-0.029716883,
0.024430322,
-0.00957188,
-0.0110270195,
0.024750719,
-0.008724161,
0.013129629,
-0.007142198,
0.0021676903,
-0.011307367,
-0.019824605,
0.006384591,
-0.024563821,
-0.01775537,
-0.016180081,
0.0046491036,
-0.0020341915,
0.015966484,
0.01158104,
0.007689544,
-0.014351145,
-0.02341573,
-0.0051030004,
-0.004762578,
0.04239929,
-0.014644843,
-0.013430002,
-0.018863412,
0.013883899,
-0.0043120184,
0.008316989,
0.011807988,
0.025004368,
-0.009959027,
-0.021453293,
-0.057778377,
0.011727889,
0.0114742415,
-0.016807526,
0.0037179478,
-0.0036378484,
0.0068284753,
0.0073157465,
-0.0027717736,
0.012128387,
-0.020011503,
0.011180543,
-0.042853188,
0.00051689154,
-0.025071116,
-0.0033274633,
0.032493662,
-0.00885766,
0.015806284,
0.023789527,
0.023242181,
-0.0147649925,
0.021560093,
0.021466643,
-0.0050262385,
0.016140033,
-0.027634298,
0.016834227,
-0.012902681,
-0.01791557,
-0.0073491214,
-0.034923345,
-0.019490859,
0.014711592,
-0.0062777917,
-0.014177596,
-0.0008719155,
0.019757856,
0.0049661635,
0.032280065,
0.0057871826,
-0.025258016,
0.012435434,
0.0071688974,
-0.010446299,
0.032333463,
-0.011360767,
0.014845092,
0.018182566,
-0.018089117,
0.02615246,
0.0069619743,
0.004882727,
-0.014604793,
-0.0054434226,
-0.035911236,
-0.011641115,
-0.008583987,
0.00036545357,
0.0023779513,
0.03014408,
0.01368365,
0.0018339428,
-0.000055746274,
-0.024390273,
-0.021933889,
-0.02170694,
0.011314042,
0.01921051,
-0.016994426,
-0.02445702,
0.018195918,
-0.0018539677,
0.009818853,
-0.0037446476,
0.010873496,
-0.021439943,
0.014711592,
-0.015846334,
0.026472857,
-0.008717487,
-0.006498065,
-0.012095012,
0.013042855,
0.027153702,
-0.0026182497,
-0.004385443,
0.022988532,
0.0011672821,
0.014124197,
-0.01768862,
-0.000065028624,
0.0010296112,
-0.0035310492,
0.011187218,
0.007969892,
-0.024283472,
0.018756613,
-0.00061326113,
0.01913041,
-0.015232239,
-0.0040249955,
0.010813421,
-0.019864654,
-0.034496147,
0.00958523,
-0.033454854,
-0.027313901,
-0.010105876,
0.007669519,
0.004105095,
0.009651979,
0.004538967,
-0.010266075,
-0.015886383,
0.0030771524,
-0.010586472,
-0.031612568,
-0.010065827,
0.03697923,
0.013343227,
0.0037179478,
0.019050311,
0.000107424996,
0.012014912,
0.0034309248,
0.034709748,
-0.0150052905,
0.027580898,
-0.0073090717,
0.026366057,
0.022240937,
0.004906089,
-0.019490859,
-0.011047045,
-0.020999396,
-0.008637387,
0.020158352,
0.012288585,
0.0822888,
-0.0070821233,
-0.040103108,
-0.009565205,
-0.0136436,
0.031746067,
0.016113332,
0.033935454,
-0.040263306,
-0.00051897747,
0.025551714,
-0.04218569,
0.022080738,
-0.012875981,
-0.016820878,
-0.0016270194,
-0.0027033552,
0.0075026453,
-0.005506835,
0.01770197,
-0.010206001,
-0.012568933,
-0.0021176282,
0.025418214,
-0.054280702,
-0.016941026,
0.03951571,
-0.010746672,
-0.008704136,
-0.0014184271,
-0.018543014,
0.006811788,
-0.036338434,
0.0074425708,
0.0047392156,
0.006371241,
-0.0008060004,
-0.009485106,
0.041651696,
0.013503427,
0.0040383455,
-0.015632736,
0.0017471685,
-0.0067617255,
0.0138038,
-0.011407492,
0.0013867212,
-0.006955299,
-0.010332825
] |
Endocytic mechanisms control the lipid and protein composition of the plasma membrane, thereby regulating how cells interact with their environments. Here, we review what is known about mammalian endocytic mechanisms, with focus on the cellular proteins that control these events. We discuss the well-studied clathrin-mediated endocytic mechanisms and dissect endocytic pathways that proceed independently of clathrin. These clathrin-independent pathways include the CLIC/GEEC endocytic pathway, arf6-dependent endocytosis, flotillin-dependent endocytosis, macropinocytosis, circular doral ruffles, | [
-0.012659538,
0.019093286,
0.0076815058,
-0.03361146,
-0.013179436,
0.020237064,
-0.0015142055,
0.0060795676,
-0.021653788,
0.00043582148,
0.020224066,
0.010826894,
0.0065767206,
0.031635847,
-0.013283417,
0.0032981085,
0.021523813,
0.01758558,
-0.024708195,
0.033351514,
-0.02595595,
0.015505984,
0.0103589855,
-0.041409947,
-0.0068496675,
0.0016961701,
0.022433637,
-0.04647896,
-0.007636015,
-0.025540031,
-0.0015133931,
0.00023781312,
-0.012893492,
-0.000005191373,
0.0070251334,
-0.01074241,
0.03212975,
-0.0012014539,
0.009722109,
-0.007571027,
0.004617352,
0.022446634,
-0.0114702685,
0.00935818,
0.0079154605,
0.00033529417,
0.002456522,
0.005098258,
-0.017923513,
0.017572582,
0.025319075,
0.014687143,
-0.016779736,
-0.011580748,
-0.042033825,
0.00029569247,
-0.028256504,
0.027528645,
0.017481599,
-0.02739867,
0.008344377,
-0.008591329,
0.00048699902,
-0.01398528,
0.014752131,
0.04185186,
0.01753359,
0.01187319,
0.0017335378,
0.011119337,
0.019002303,
0.017949509,
-0.012484072,
0.013198933,
0.009371177,
-0.02802255,
-0.036288943,
-0.00709662,
-0.016363816,
0.019769154,
-0.0015767558,
-0.005195739,
0.0121786315,
0.041098006,
0.003655539,
-0.0164548,
0.028646428,
0.021523813,
-0.008025939,
0.007856972,
-0.00054629997,
0.009891076,
0.012503568,
0.010859388,
-0.017286638,
0.010618934,
0.009169716,
0.007265587,
-0.0033127307,
-0.007928458,
-0.0055954116,
0.028516453,
-0.0031551362,
-0.01974316,
-0.019080289,
-0.023200488,
0.006791179,
-0.021224871,
0.021432832,
0.00040414016,
-0.0103589855,
0.0022274416,
-0.008818785,
-0.048714526,
0.038888436,
0.009104729,
0.016181853,
-0.009033243,
-0.010306995,
-0.002734343,
-0.009462159,
0.024851166,
0.02524109,
-0.004653095,
0.025579024,
0.0046206014,
-0.008974754,
-0.008350875,
0.0063005243,
0.0063687614,
-0.0017042935,
0.02760663,
-0.025644012,
0.0025540031,
-0.039044406,
-0.0076425136,
0.0050300215,
0.016116865,
-0.003999972,
-0.018105479,
0.007947954,
0.044633318,
-0.0037757657,
-0.00084808504,
-0.008714805,
0.028698418,
0.007090121,
0.038342543,
0.0046141027,
0.0035255642,
0.022342654,
0.008695309,
0.013621351,
-0.025163105,
0.016493792,
0.032883603,
0.009813092,
0.016831726,
-0.0040877047,
-0.01948321,
0.005562918,
0.0074410527,
0.011899185,
-0.0070056375,
0.0426837,
0.023161495,
0.016337821,
0.017780542,
0.0122371195,
0.015596966,
-0.009572638,
0.013218429,
-0.017728552,
0.014180242,
-0.0082858885,
0.020912932,
0.019184269,
0.02061399,
-0.043541532,
-0.039928235,
-0.01121032,
-0.0039349846,
0.020912932,
0.0044548833,
-0.004406143,
-0.015843919,
0.01527203,
-0.019756157,
0.022238674,
-0.028516453,
-0.013972282,
0.02374638,
-0.023629405,
-0.016597772,
-0.62845373,
-0.030258115,
0.004253423,
-0.012705029,
-0.013894297,
0.022888549,
0.01496009,
-0.007850473,
0.010196516,
0.016493792,
-0.017559584,
0.021874744,
0.008870775,
-0.02997217,
-0.021354847,
-0.03428733,
-0.021627793,
-0.007817979,
0.026618822,
0.0031713832,
-0.036522895,
-0.0045068734,
-0.019600188,
0.011067348,
0.014518176,
0.001964243,
0.015843919,
-0.0054329433,
-0.024344265,
0.027840585,
-0.024981141,
0.010170522,
-0.008149415,
0.009423167,
0.038030602,
0.0069081564,
-0.0016847973,
0.019925125,
-0.002225817,
0.043619517,
-0.0215888,
-0.019808147,
-0.0052867215,
0.009377676,
-0.025929956,
0.012308606,
0.007967451,
0.009949565,
-0.017806536,
-0.01727364,
0.012419084,
0.013348403,
-0.024409251,
0.0059820865,
0.0050885105,
0.016818728,
0.02595595,
-0.0109568685,
-0.002581623,
0.02379837,
-0.004734329,
0.0145961605,
-0.031895798,
-0.028932372,
-0.007843974,
0.01768956,
-0.02148482,
0.019717164,
-0.0033013579,
0.022394644,
0.0068041766,
0.00008686982,
-0.008259893,
0.010534451,
0.004448385,
0.009722109,
0.0021673285,
0.014414196,
-0.012542561,
0.0092801945,
0.011782208,
-0.00034382375,
-0.009182714,
0.012126641,
0.013257422,
0.018677367,
0.0005393951,
0.021913737,
0.028880382,
0.00051461864,
-0.008389868,
0.0014882105,
-0.0073435716,
-0.04174788,
-0.038498513,
0.016051877,
-0.0012583177,
-0.00344433,
0.0019155024,
-0.017455604,
0.0040552113,
-0.019548198,
-0.0027375924,
-0.012848001,
0.036106978,
0.008422362,
-0.025423056,
0.017143665,
0.045257196,
-0.013530368,
0.011138833,
0.0060698194,
0.00740206,
-0.010820395,
-0.018859332,
-0.020185074,
0.014986085,
0.03433932,
0.010709917,
-0.026501846,
0.006797678,
-0.00920221,
0.00008082803,
-0.010027549,
-0.011853694,
0.00282695,
-0.013036464,
-0.025280083,
-0.019977115,
0.006765184,
-0.004929291,
0.009949565,
0.029322296,
-0.013224928,
0.020185074,
0.044607323,
0.011138833,
0.0008627072,
-0.008539339,
-0.03779665,
-0.014388202,
-0.0058131195,
0.01151576,
-0.025462048,
0.0018391423,
-0.008812286,
-0.025124114,
-0.0046595936,
0.020068096,
0.00087651704,
-0.0049325405,
-0.023408446,
-0.008441858,
0.03023212,
0.01727364,
0.0032087509,
-0.0344433,
-0.02550104,
-0.0025410058,
-0.017234648,
0.010319993,
-0.00067099446,
-0.030700028,
0.013465381,
0.015077068,
-0.016727746,
0.023577414,
-0.0008919515,
-0.006284278,
-0.03475524,
0.020523008,
-0.0058586104,
-0.033533476,
0.026241897,
0.011190823,
0.015973892,
0.00642725,
0.0049227923,
-0.007018635,
-0.014778125,
0.009468658,
-0.031583857,
0.0032168743,
-0.016597772,
0.04096803,
0.01382931,
0.042501733,
0.008669314,
-0.0042404253,
0.03743272,
-0.0056571495,
-0.0012648165,
0.0042339265,
0.022147693,
0.00981959,
-0.023070512,
0.027372675,
0.01177571,
0.012302107,
0.014726136,
0.0141412495,
-0.03506718,
0.0022128196,
-0.02385036,
0.011281806,
-0.009572638,
0.0032607408,
-0.011476767,
-0.0053842026,
0.019964118,
-0.0010779778,
0.012432082,
0.0023720386,
-0.020094091,
0.0138553055,
0.01783253,
-0.0027132223,
-0.0005231482,
-0.040500123,
-0.0018602632,
-0.00524448,
-0.020445023,
0.018703362,
-0.009631127,
-0.01661077,
0.004116949,
-0.002956925,
0.042579718,
-0.009657121,
-0.026384868,
-0.0043054125,
-0.008643319,
0.013250923,
0.03002416,
-0.0031681338,
0.014284221,
0.023148498,
0.0097351065,
0.03644491,
0.0055044293,
0.0069796424,
0.028854387,
0.01326392,
0.001280251,
-0.01121032,
-0.010203015,
0.0022436886,
0.025059126,
0.0003836285,
-0.008051934,
0.00061697373,
0.014427193,
-0.034027383,
-0.00688866,
-0.0057253866,
-0.016974699,
0.005195739,
-0.0021120892,
0.024097312,
0.01511606,
-0.012126641,
-0.018794345,
-0.00617055,
-0.020016106,
0.014219235,
0.011860193,
0.002328172,
-0.01567495,
-0.014258226,
0.004149443,
-0.012536062,
-0.010508456,
0.018937316,
-0.021991722,
0.023395449,
0.027736604,
0.022498624,
-0.026111921,
0.01871636,
0.015129058,
-0.013868302,
-0.018131474,
0.0018911322,
0.023915349,
-0.012692031,
-0.004107201,
-0.031765822,
-0.003270489,
-0.013250923,
0.001496334,
-0.0052054874,
-0.0005532049,
0.015882911,
-0.0052249837,
-0.039356343,
-0.009208709,
0.006349265,
-0.007778987,
0.020003108,
-0.007876468,
0.0042404253,
-0.00076157064,
-0.010683922,
0.0067846803,
0.04200783,
0.013335406,
0.017507594,
-0.0072525893,
-0.0013655468,
-0.030102145,
-0.0012696906,
-0.013556363,
0.004399644,
-0.030985974,
0.0236554,
-0.002199822,
-0.0056474013,
0.0019252505,
0.020068096,
0.027892575,
-0.026800787,
-0.024435246,
0.000110580055,
-0.0010536076,
0.029270306,
0.01758558,
0.0021445828,
0.034469295,
-0.00344433,
-0.018729357,
-0.01598689,
-0.0074215564,
0.026956758,
-0.019197267,
-0.012744022,
-0.014570166,
-0.018183462,
0.0001303809,
0.029036352,
0.028750408,
-0.011606743,
-0.009865081,
0.009475157,
-0.008175409,
0.02169278,
-0.009884577,
0.027086731,
0.0063362676,
0.013790318,
-0.0035905517,
0.0036132971,
0.023915349,
0.0005982899,
-0.0076425136,
0.017715555,
0.0061510536,
0.0012144513,
0.008903268,
-0.023824366,
-0.021380842,
0.013712333,
-0.006797678,
0.0070446297,
0.016519787,
0.00069820794,
0.016649762,
-0.011717221,
-0.003814758,
-0.005033271,
-0.007018635,
0.02411031,
0.023122502,
0.0012835003,
-0.0241623,
0.033689447,
0.0060113305,
0.010449967,
-0.020704973,
-0.006372011,
-0.0075190375,
0.021991722,
-0.007467048,
0.0060698194,
-0.017455604,
0.0000054388834,
0.007752992,
-0.012679034,
-0.015337016,
0.0048708026,
-0.024552224,
0.0001261161,
-0.025968948,
-0.020652983,
0.007980448,
0.00833138,
-0.038004607,
-0.028152524,
-0.0025523785,
-0.0017059182,
0.029348291,
0.014401199,
-0.017403616,
0.0106449295,
0.029686226,
0.0030414085,
-0.00060235156,
0.0020227316,
-0.036886826,
0.00069658324,
0.02066598,
0.017572582,
-0.007408559,
-0.008324881,
-0.0071746046,
0.025851972,
-0.011125836,
0.030622045,
-0.0031746326,
-0.0025475044,
0.019392228,
-0.0018716359,
0.03207776,
0.007161607,
-0.015947899,
-0.0037400224,
-0.017286638,
-0.01603888,
0.00087164296,
-0.009156719,
-0.008929263,
-0.005163246,
0.00052396057,
-0.011580748,
0.009312688,
0.010300497,
-0.013764323,
-0.016402809,
-0.00812342,
-0.0026612324,
0.051080063,
-0.016623767,
0.03249368,
0.013660343,
-0.024747187,
-0.00699264,
-0.007135612,
0.028906377,
0.0034475795,
-0.019080289,
0.015804926,
-0.007882967,
0.0054881824,
-0.019119281,
-0.019522203,
-0.001717291,
0.024123307,
-0.0041104504,
-0.01989913,
-0.004542616,
-0.019977115,
-0.016922709,
-0.0036392922,
-0.023629405,
-0.0054816836,
-0.010735911,
0.00011626645,
0.007902463,
-0.0059300964,
0.009163218,
-0.04153992,
0.008974754,
0.025968948,
0.0023249227,
0.010839892,
-0.0023622906,
0.012425583,
-0.033871412,
-0.020263059,
-0.02647585,
-0.05289971,
-0.014011275,
0.005728636,
0.041098006,
0.01891132,
0.01984714,
0.0033208542,
0.03782264,
0.010475962,
0.0033078566,
-0.0001855186,
0.017039686,
-0.0023915349,
-0.034261335,
0.012367095,
-0.0028626933,
-0.012334601,
0.04416541,
-0.033871412,
0.018105479,
-0.0056896433,
0.01043697,
-0.026800787,
0.0042274278,
-0.020172076,
-0.013361401,
0.03454728,
-0.0030316603,
-0.006934151,
-0.021146886,
-0.025046129,
-0.008415863,
0.009000749,
-0.0034865718,
-0.015791928,
0.030933984,
-0.026163911,
0.017299635,
-0.019665174,
-0.00072501524,
-0.0044126417,
-0.017663565,
-0.026241897,
-0.011691226,
0.012159135,
-0.017559584,
0.016363816,
0.015791928,
0.0035125667,
-0.011645735,
0.0072200955,
-0.00131112,
-0.026540838,
0.008935762,
-0.014752131,
-0.02405832,
-0.027242702,
-0.027294692,
-0.028360484,
0.0005219297,
0.021211874,
0.002282681,
0.019548198,
-0.016727746,
-0.004841558,
0.050118253,
-0.0035060681,
0.014401199,
-0.0030479073,
0.01783253,
0.012516566,
0.012770016,
-0.03012814,
-0.003973977,
-0.020562,
0.0052672257,
0.05557719,
0.039616294,
0.016948704,
-0.023629405,
-0.020016106,
0.002411031,
-0.0041104504,
-0.041305967,
0.013302913,
0.018586384,
-0.0017367871,
-0.024760185,
0.0012233871,
-0.014492181,
0.0028578192,
-0.013491375,
0.009514149,
-0.0059008524,
-0.010911378,
-0.022810563,
0.047882687,
0.017013691,
0.014284221,
-0.0064240005,
-0.01018352,
0.013400394,
-0.013413391,
-0.0026921013,
-0.002874066,
-0.0105604455,
0.00632327,
0.004952037,
-0.012055155,
0.026137916,
0.023408446,
-0.0010495458,
-0.03758869,
0.009546643,
0.038498513,
-0.004451634,
-0.00044150787,
0.009163218,
-0.014206237,
0.0047083343,
-0.025033131,
-0.010995861,
-0.008246896,
-0.012770016,
-0.006586469,
0.030414084,
0.0031811313,
-0.017715555,
-0.02411031,
-0.018859332,
0.0058943536,
-0.03301358,
-0.012945482,
0.024903156,
-0.038394533,
0.002693726,
0.003125892,
0.0096506225,
0.014882105,
0.0008553961,
0.012503568,
-0.017091675,
0.05069014,
-0.0063882573,
0.022329656,
-0.004695337,
-0.019782152,
-0.017676562,
0.007941456,
-0.027242702,
-0.030310104,
0.0018277694,
-0.016285833,
-0.019353235,
-0.004292415,
-0.019262254,
0.026501846,
0.012471074,
-0.0051405,
0.0026612324,
0.010086038,
0.023681393,
-0.007259088,
0.010209514,
-0.005026772,
-0.038316548,
0.0021445828,
0.014011275,
-0.024812173,
-0.026384868,
0.012562057,
-0.010060043,
0.008188407,
-0.0023346709,
-0.005377704,
-0.0055759153,
-0.020990917,
-0.0006494674,
0.004396395,
-0.0062485347,
-0.005182742,
-0.002066598,
-0.00472783,
-0.005059266,
-0.026670812,
-0.008675813,
-0.01419324,
0.024942148,
-0.000009088076,
-0.02797056,
0.013790318,
0.0040877047,
-0.013647346,
-0.013153441,
0.0020942176,
-0.022277666,
0.038160577,
0.0060860664,
0.005104757,
-0.017507594,
0.00868881,
-0.045569137,
-0.019834142,
-0.0082014045,
0.011892687,
-0.01819646,
0.017702557,
0.011288304,
0.017728552,
-0.002164079,
-0.0071551083,
0.002477643,
-0.010859388,
0.021068903,
-0.033351514,
0.0029536756,
-0.0034215844,
-0.010313494,
-0.013647346,
0.033975393,
-0.008487349,
-0.00750604,
0.016233843,
0.0000027099222,
0.018170465,
-0.0015645707,
0.0009845585,
0.0141412495,
0.015376009,
0.0102745015,
-0.02642386,
-0.002812328,
0.006914655,
-0.0023704139,
-0.024396256,
0.0029617988,
0.0047083343,
-0.0101900175,
0.005614908,
0.005517427,
-0.019119281,
0.008890271,
-0.010605937,
0.0029617988,
0.009416669,
-0.008493848,
0.024357263,
0.0043379064,
-0.024942148,
-0.005640903,
0.013289915,
-0.02252462,
0.012932485,
-0.013959285,
0.0020795956,
-0.00354831,
0.009631127,
0.0074930424,
-0.023876356,
-0.00909823,
0.008038936,
0.0033403502,
-0.030985974,
0.0053192154,
-0.008526342,
-0.010859388,
-0.00941017,
-0.0023427943,
-0.00833138,
-0.023356456,
-0.004461382,
-0.009143721,
-0.019015301,
0.013413391,
-0.0005649839,
0.0009878079,
-0.0021981974,
-0.013153441,
-0.00074126205,
-0.011528757,
0.007876468,
0.18248451,
-0.025124114,
0.01979515,
0.004116949,
-0.029400282,
-0.021614796,
0.011392284,
0.011606743,
0.0061575524,
0.005423195,
0.015350014,
0.029192321,
-0.007571027,
-0.0015458869,
0.016532784,
-0.019600188,
-0.049338404,
-0.011366289,
0.005098258,
0.018976308,
-0.015103063,
-0.01815747,
0.020717971,
0.00493579,
0.050612155,
-0.007259088,
-0.020730969,
0.012204626,
-0.0014817117,
0.024292275,
-0.014973087,
-0.00065637234,
0.008935762,
0.004285916,
0.011119337,
0.01367334,
-0.009611631,
0.0050040265,
0.005299719,
-0.003645791,
0.0046498454,
-0.0048545557,
0.0045393673,
-0.017806536,
-0.008422362,
0.003733524,
-0.01943122,
-0.027190711,
-0.00431841,
-0.0008960132,
-0.05932046,
0.034677256,
0.00008270657,
0.014869108,
-0.007889465,
-0.013400394,
-0.0065474766,
0.015999887,
0.0072005996,
0.029322296,
-0.015843919,
0.006385008,
-0.01048896,
0.01393329,
-0.011099841,
0.015389007,
-0.01192518,
-0.0136863375,
0.04348954,
-0.017442606,
-0.004451634,
0.0143102165,
-0.018079484,
-0.023629405,
0.0050397697,
-0.01650679,
0.019561196,
0.024474239,
0.024357263,
0.029088343,
-0.0073890625,
0.017962506,
-0.040318158,
-0.0012794386,
0.0053614574,
-0.028126528,
0.003418335,
0.0012656288,
-0.010086038,
0.0065019852,
0.007532035,
-0.009208709,
-0.0015767558,
0.0024695196,
0.029790206,
0.0036880327,
-0.0032574914,
0.0076425136,
-0.013660343,
-0.033897407,
-0.023044517,
0.076789066,
0.047908682,
0.03140189,
0.004997528,
0.024981141,
-0.030518064,
0.009624628,
-0.000330217,
-0.019457215,
0.020652983,
-0.019301245,
-0.009553142,
-0.029842196,
-0.027216706,
0.010716416,
0.036834836,
-0.015817923,
0.057500817,
-0.013842308,
-0.021276861,
-0.011190823,
0.016233843,
0.0049390392,
0.0016620518,
0.014427193,
-0.028282499,
-0.0009016996,
0.011353292,
-0.025462048,
-0.016532784,
-0.0028968116,
-0.022953534,
-0.013972282,
0.0071226144,
0.0022095703,
0.022511622,
-0.0057773762,
-0.019665174,
0.01377732,
-0.0027262198,
0.012822006,
0.01269853,
0.01989913,
0.0057091396,
0.0014695267,
0.015453994,
0.0094491625,
-0.037146773,
-0.030154135,
-0.009780598,
-0.011450773,
-0.0078309765,
0.0028042046,
0.014531174,
-0.04107201,
-0.0018586385,
-0.020847945,
0.009624628,
-0.0030430332,
-0.029504262,
0.0043833973,
0.021380842,
-0.023213485,
0.008838281,
0.006242036,
-0.16064875,
0.013140444,
0.011353292,
0.0035580578,
0.022017717,
0.012419084,
0.013946287,
0.02102991,
-0.020834947,
-0.01577893,
0.040266167,
0.008240397,
-0.048142634,
-0.03517116,
-0.003912239,
-0.0048285606,
-0.0063265194,
0.010547449,
-0.00755803,
0.0008326505,
0.025825977,
-0.04725881,
0.0029845445,
-0.011691226,
0.0004043432,
-0.0018033992,
0.007960952,
-0.013224928,
-0.008786291,
-0.005010525,
0.00033387257,
0.013920292,
0.027632626,
0.016532784,
0.016532784,
0.011242813,
-0.005718888,
0.0027278445,
-0.00755803,
0.0038732467,
0.04107201,
0.021796761,
-0.008604326,
0.024604214,
-0.004636848,
0.006076318,
0.0027180964,
-0.002900061,
0.025436053,
-0.015609964,
0.017182657,
-0.018846335,
-0.02297953,
0.02586497,
0.017195655,
0.028698418,
-0.002874066,
0.04338556,
0.017975504,
0.00046303493,
-0.010748909,
0.0015816299,
0.024097312,
-0.010813897,
0.029686226,
-0.020574998,
-0.0021965727,
0.012172133,
-0.024812173,
0.015103063,
-0.0063622626,
-0.009397172,
0.0077464934,
-0.022498624,
0.013959285,
0.031271916,
-0.0057708775,
-0.0106449295,
-0.0040584607,
0.0011096592,
-0.024591217,
0.00879279,
-0.030752018,
-0.029374287,
0.00079325197,
-0.009013747,
-0.003980476,
-0.004952037,
0.0031291414,
0.01711767,
0.019197267,
-0.01650679,
0.0002481705,
-0.01609087,
0.035249144,
0.021367844,
0.0031502622,
-0.017923513,
-0.0015296399,
-0.005185991,
0.01783253,
-0.01680573,
-0.007564529,
0.006128308,
0.019782152,
0.0036945313,
0.006284278,
-0.008604326,
0.03943433,
-0.023759378,
-0.005234732,
-0.012984474,
0.004734329,
0.015804926,
-0.0017189156,
0.016649762,
0.011444274,
-0.0041819364,
-0.01680573,
-0.010079539,
0.05984036,
-0.008032437,
0.008565334,
0.019405225,
-0.013361401,
-0.0130884545,
-0.14068463,
-0.008513344,
0.0057546305,
0.03366345,
0.0070836223,
-0.0008094988,
-0.002437026,
0.019574193,
-0.0013631099,
0.023577414,
-0.033143554,
0.020834947,
-0.0039577303,
-0.0006043824,
0.013348403,
0.001192518,
0.008662815,
-0.008604326,
-0.03553509,
0.00061128737,
0.013621351,
-0.02195273,
-0.022953534,
-0.0024419,
0.01126231,
-0.0059041018,
-0.012757018,
0.043463547,
0.00047684475,
-0.00472783,
-0.0036165465,
-0.0011210319,
0.005696142,
-0.022602603,
0.0110413525,
-0.018547392,
0.008935762,
-0.03207776,
0.053237643,
-0.0015564472,
-0.008389868,
0.020003108,
0.011782208,
-0.011730218,
0.0022241925,
-0.030362094,
-0.029582245,
-0.01126231,
-0.009949565,
0.005104757,
-0.03576904,
-0.029946174,
-0.03543111,
-0.031167937,
0.021250866,
-0.013101452,
-0.02642386,
0.025150107,
0.013153441,
0.008207903,
-0.018378425,
0.009780598,
0.006290776,
0.009858582,
0.0262289,
-0.014843113,
-0.016220845,
-0.009566139,
0.022511622,
0.011762712,
0.008779792,
0.005871608,
-0.011073846,
0.0076620094,
-0.026956758,
0.0033533478,
-0.0034638264,
-0.0056636482,
-0.017416613,
-0.018989306,
-0.0024142803,
-0.025838975,
0.007168106,
-0.0055694166,
0.030959979,
0.0073500704,
-0.0011218443,
0.011320798,
0.010703418,
-0.015129058,
0.0039057403,
0.042657703,
0.020691976,
-0.0071421107,
-0.0029081844,
0.009332185,
-0.02323948,
-0.020159079,
0.008779792,
0.03527514,
-0.012393089,
0.00043907083,
-0.048948478,
0.031037962,
0.0019138778,
0.014388202,
0.018391423,
-0.009598633,
0.010885383,
-0.03644491,
0.0138813,
0.014492181,
-0.025721997,
0.026748797,
0.005202238,
-0.0072525893,
-0.022732578,
-0.017663565,
0.03322154,
-0.004529619,
-0.0035905517,
0.04517921,
0.0038375035,
-0.0037140276,
0.0241623,
0.03218174,
-0.004159191,
0.01923626,
-0.016974699,
0.022329656,
-0.026059931,
0.0054329433,
-0.000812342,
-0.025267085,
-0.005156747,
-0.0044256393,
-0.0033793426,
-0.0034020883,
-0.023343459,
0.011489765,
0.02955625,
0.03454728,
0.012373594,
-0.027008746,
-0.0037107782,
-0.011944677,
-0.0036425416,
-0.0070511284,
-0.045361176,
0.0060698194,
-0.0035028188,
-0.03576904,
0.024903156,
-0.0014094134,
-0.0053387117,
-0.03691282,
0.003619796,
-0.00062794035,
0.014427193,
-0.012334601,
-0.008441858,
-0.04710284,
0.029842196,
0.0128545,
0.005494681,
-0.010800899,
0.011613241,
0.008129919,
-0.0364969,
0.008987752,
0.010735911,
-0.03129791,
-0.008038936,
0.011600244,
0.013621351,
0.01603888,
0.0020064847,
0.00029224003,
-0.025085121,
0.0069991387,
-0.00349632,
0.025124114,
-0.0057968725,
0.0014817117,
-0.01506407,
0.010722915,
0.034365315,
0.0077399947,
0.013699335,
0.013621351,
-0.021809759,
-0.0052249837,
-0.014388202,
0.007577526,
0.012042157,
0.00094719074,
0.01069692,
0.0034378313,
-0.0063005243,
0.014505179,
0.0013509247,
0.016337821,
-0.004734329,
0.0033176048,
-0.0036067984,
-0.027320687,
-0.011977171,
0.018001499,
-0.027788594,
-0.048974473,
-0.024396256,
0.012003166,
-0.0021299608,
-0.014661148,
0.0029780457,
-0.017598577,
-0.024708195,
0.019626183,
-0.0027050988,
0.0006823673,
-0.008461354,
-0.0032152496,
0.009059238,
0.008630321,
-0.0023054266,
-0.014362207,
-0.009540144,
0.0136863375,
0.009065737,
-0.010144527,
0.03743272,
0.002653109,
-0.0006539353,
-0.007031632,
-0.028594438,
-0.013348403,
-0.0060373256,
-0.0128545,
-0.005536923,
0.00042688573,
-0.026384868,
0.08183208,
0.0014890229,
-0.0066417083,
-0.0027895824,
-0.007460549,
0.047284804,
0.012990973,
0.03371544,
-0.031219928,
-0.01882034,
0.013491375,
0.0047408277,
0.025994943,
-0.0431776,
0.0039447327,
0.022953534,
-0.017897518,
-0.0067781815,
0.01727364,
-0.021796761,
-0.0092542,
-0.04380148,
-0.0064337486,
0.021653788,
-0.018924318,
0.018209457,
0.0313499,
-0.0031356402,
-0.00052842847,
-0.01774155,
0.0050722635,
0.0071226144,
-0.03901841,
-0.015103063,
-0.0020243563,
-0.006693698,
-0.0395903,
-0.0037920123,
-0.012880495,
0.004253423,
-0.0060633207,
-0.0070121363,
-0.016311828,
-0.03566506,
-0.009676618,
-0.011645735,
-0.0033403502,
0.006235537,
-0.03223373
] |
BACKGROUND Birth size, perhaps a proxy for prenatal environment, might be a correlate of subsequent breast cancer risk, but findings from epidemiological studies have been inconsistent. We re-analysed individual participant data from published and unpublished studies to obtain more precise estimates of the magnitude and shape of the birth size-breast cancer association. METHODS AND FINDINGS Studies were identified through computer-assisted and manual searches, and personal communication with investigators. Individual participant data from 32 studies, comprising 22,058 breast cancer cases, were obtained. Random effect models were used, if appropriate, to combine study-specific estimates of effect. Birth weight was positively associated with | [
0.0019663745,
-0.022823581,
0.021342712,
-0.035333034,
-0.03348844,
-0.007228983,
-0.00062961323,
0.010060822,
-0.021875305,
-0.030786505,
-0.0034586105,
0.0018949289,
0.0059754397,
0.006387875,
-0.022109127,
0.008865734,
0.041750137,
0.0022813838,
-0.005381143,
0.0050174207,
-0.025837282,
0.0077031213,
-0.0064333403,
-0.0032962344,
-0.0043809065,
0.015756976,
0.027772805,
-0.035099212,
0.017185884,
-0.027461043,
0.016094718,
0.011100029,
-0.020706197,
-0.0052837175,
-0.035333034,
0.008742328,
0.015276342,
-0.01806921,
0.00015669291,
-0.0059104892,
-0.014211155,
0.015951827,
0.0018998001,
-0.0008492269,
-0.019991742,
-0.0051700543,
0.03317668,
-0.0082551995,
0.006475558,
0.01502953,
0.010301138,
0.020875068,
-0.018316021,
0.020199584,
-0.034034025,
-0.0050206683,
-0.00905409,
0.026097083,
0.014756738,
-0.00674835,
0.010216703,
0.0047186487,
-0.021992216,
0.0074433195,
0.0072679534,
0.0038385706,
0.00566043,
0.04071093,
-0.0055759945,
0.03632028,
0.017783428,
0.03146199,
0.0018624536,
0.0072874385,
0.0005086431,
-0.005225262,
-0.01958905,
-0.0021125127,
-0.0085474765,
0.014574877,
-0.000522445,
-0.0021482354,
0.021719424,
0.031981595,
-0.017133923,
0.006137816,
-0.014276105,
-0.004000947,
0.015185411,
-0.0031744523,
0.0033449472,
-0.009924426,
-0.0051213414,
0.0037898577,
0.0018721962,
-0.00019667803,
0.0001236088,
0.026525756,
0.011879434,
-0.029461516,
0.010989613,
0.0033287096,
-0.0035462936,
-0.009541218,
-0.026110074,
0.0094372975,
-0.02270667,
-0.0094372975,
0.008774803,
-0.02119982,
-0.021706434,
0.0147957085,
-0.012730285,
-0.01973194,
0.010073812,
-0.013860422,
-0.011580662,
0.011210444,
-0.0032702542,
0.0018900576,
0.022018196,
0.001425662,
0.047725577,
-0.02104394,
0.012360067,
0.003265383,
-0.049258407,
-0.014639827,
-0.012431513,
-0.00525449,
-0.0023901758,
0.005972192,
0.010833732,
0.009235951,
-0.0269934,
0.003318967,
-0.0041211047,
-0.031046307,
-0.01962802,
-0.030396802,
0.0055435193,
0.020069683,
-0.02119982,
-0.0059981723,
-0.0147957085,
0.0212258,
0.023330195,
0.029149754,
-0.01640648,
-0.02547356,
-0.0011788503,
0.010788267,
0.010314128,
0.004634213,
0.01347072,
-0.0006032271,
-0.013886402,
0.03476147,
-0.013652581,
-0.030422783,
0.0069756764,
0.022083146,
-0.0016383746,
0.004371164,
0.012340582,
0.03767125,
0.013152462,
-0.026226984,
0.010963633,
-0.014457966,
-0.027746825,
0.011639117,
-0.04845302,
0.012600384,
0.003176076,
0.017017012,
-0.007066607,
0.017900338,
-0.015666045,
-0.032215416,
-0.024551263,
0.0028139774,
0.021290751,
0.0014451471,
-0.007859003,
0.0040496597,
0.017004022,
-0.013100502,
0.0014451471,
-0.027746825,
0.0030137,
0.015146441,
-0.013366799,
-0.02270667,
-0.6484651,
-0.021901285,
0.0075667254,
-0.005082371,
0.01656236,
0.013626601,
0.005455836,
0.007683636,
0.0022651462,
0.023823818,
-0.008014884,
0.030682584,
0.011892424,
0.015523153,
-0.0041568275,
-0.010099792,
0.0077355965,
-0.020550316,
0.029903179,
-0.013782482,
-0.011749533,
0.02865613,
-0.00064300926,
0.030864445,
-0.0009482763,
0.0150944805,
0.008768308,
-0.018679744,
0.022810591,
0.028058587,
-0.0103336135,
0.027435062,
0.0026857003,
0.0013753254,
0.039541822,
-0.03600852,
-0.004215283,
0.04369865,
0.008735833,
0.020290514,
-0.019368218,
-0.021862315,
0.017692497,
0.011697573,
-0.007995399,
0.028941913,
0.010249178,
0.0035657787,
0.012450998,
-0.014574877,
-0.004501065,
0.017809408,
0.00640736,
-0.010853217,
0.022758631,
-0.021303741,
0.035099212,
-0.017030003,
0.000055004897,
-0.01673123,
0.0014581372,
-0.003060789,
0.0009839991,
-0.0011074048,
0.001997226,
0.021537563,
-0.01623761,
0.011327355,
-0.025915222,
0.002205067,
0.0094372975,
0.03247522,
0.010476504,
-0.010314128,
0.02269368,
0.035644796,
0.014912619,
-0.011736543,
-0.015808936,
-0.006287202,
0.013204423,
0.0011187711,
-0.030188961,
0.010651871,
0.0137565015,
-0.02404465,
-0.011548187,
0.0035203134,
-0.021719424,
-0.0014126719,
0.019160377,
-0.016159669,
-0.015289332,
-0.019433169,
0.0037054222,
0.004228273,
-0.0128666805,
0.010171237,
0.011613137,
-0.0122691365,
-0.023641957,
0.00077088043,
-0.009073575,
0.006767835,
0.027461043,
0.001969622,
-0.0066087064,
0.00752126,
0.026045123,
-0.020706197,
0.029279655,
0.032085516,
-0.011846959,
0.0009076823,
0.026175024,
-0.01822509,
-0.0057935785,
0.012139236,
-0.007203003,
0.005098609,
0.028708091,
0.02701938,
-0.023044413,
-0.017081963,
0.026162034,
0.023356175,
0.0015036025,
0.018874595,
0.022420889,
-0.02565542,
-0.004932985,
0.0012202562,
-0.003617739,
0.0029958386,
0.011859949,
-0.008833258,
-0.001092791,
-0.0052837175,
-0.014483946,
-0.009995871,
-0.030630624,
-0.005679915,
0.011580662,
-0.0042575006,
-0.0044361143,
-0.029721318,
-0.028915932,
0.005062886,
-0.011061058,
0.002144988,
-0.0076121907,
-0.024564253,
-0.010392069,
0.011872939,
0.010580425,
0.0039489865,
0.015458203,
-0.015432223,
0.010898682,
0.0025135817,
0.0030721554,
0.025434589,
-0.023148334,
-0.0038937784,
0.002851324,
-0.028734071,
-0.017419705,
-0.0019241566,
0.00828118,
-0.04367267,
0.005748113,
-0.02260275,
0.017861368,
0.0058000735,
-0.018718714,
-0.004689421,
-0.029461516,
-0.01957606,
-0.021329721,
0.0025493044,
0.007956428,
-0.0269934,
-0.01819911,
0.0071705277,
0.06146909,
0.02553851,
0.01201583,
-0.023057403,
-0.015990797,
0.015289332,
-0.023628967,
0.032968838,
-0.011794998,
0.026213994,
0.01628957,
-0.022446869,
-0.007209498,
0.014302085,
0.01348371,
0.013256383,
0.00674835,
0.01352268,
0.030240921,
0.0064398353,
0.017900338,
-0.021784374,
0.011853454,
-0.007066607,
0.0026045123,
-0.011769018,
0.0077291015,
0.0034163927,
-4.1228301e-7,
-0.0041698175,
-0.009697099,
-0.007683636,
-0.008631912,
-0.010210208,
0.006046885,
0.0051538167,
-0.0048290645,
0.010242683,
0.026369875,
0.0034910857,
-0.01803024,
0.030734545,
0.01641947,
-0.01497757,
0.0059624496,
-0.006650924,
-0.0025817796,
0.015588104,
0.008242209,
0.0012097018,
-0.007897973,
-0.023070393,
0.01826406,
-0.017900338,
-0.01357464,
0.020719187,
-0.0060793604,
0.007047122,
-0.00406265,
0.013808462,
0.003523561,
-0.030474743,
0.013191433,
0.022239028,
-0.009612664,
-0.023512056,
0.024564253,
-0.00014583401,
-0.017731467,
0.02248584,
0.009528228,
-0.016198639,
0.008618922,
0.009710089,
0.01826406,
0.027668884,
0.03650214,
0.008813773,
-0.0045432826,
0.021797365,
0.0034261353,
-0.0063229245,
0.0081253,
-0.0015579985,
-0.007794052,
0.012152226,
-0.02412259,
-0.032241397,
-0.00030526702,
-0.032890897,
-0.008053854,
-0.008618922,
-0.0030445515,
0.022213047,
0.007677141,
0.014912619,
-0.006618449,
-0.010320623,
0.023447106,
0.04380257,
0.00113988,
-0.0065827263,
0.0062222513,
0.007631676,
0.00820324,
-0.0025687895,
0.029669357,
0.021459622,
-0.00013172759,
-0.020134633,
-0.00041040554,
-0.008144785,
0.0012226918,
0.0020849088,
0.007060112,
-0.008430566,
0.0019322754,
-0.010541455,
-0.024927976,
0.004039917,
0.025057876,
0.01202882,
-0.010340109,
-0.027305162,
-0.004819322,
0.010281653,
-0.012613374,
-0.01958905,
-0.00528047,
0.012308107,
0.00083867245,
0.013282363,
0.016796181,
-0.0045237974,
0.008729338,
0.018692734,
0.0016513647,
-0.02547356,
-0.033800203,
0.012132741,
0.04954419,
0.02709732,
0.0015084738,
0.024525283,
0.012489968,
0.0010392069,
-0.0013615234,
-0.00987896,
0.003068908,
0.0210959,
-0.017237844,
0.0020881563,
0.041464355,
0.0034975808,
-0.020797128,
0.020810118,
0.006605459,
-0.021823345,
-0.006469063,
-0.0072614583,
-0.014639827,
-0.005920232,
0.031929635,
0.058143627,
0.036995765,
-0.010450524,
0.006270964,
0.03769723,
0.0028561952,
0.0036502143,
-0.031669833,
0.043386888,
-0.0060241525,
0.03494333,
-0.011327355,
0.0044555995,
0.0136136105,
0.0058357962,
-0.0019744933,
0.0077485866,
0.0225378,
0.006910726,
0.010489495,
0.009171001,
0.02407063,
-0.016185649,
0.02118683,
0.010885692,
0.014600857,
-0.015860897,
0.025031896,
0.013405769,
-0.0013534046,
-0.029279655,
0.009313892,
-0.00817726,
0.013834442,
-0.009995871,
-0.0035852639,
-0.005007678,
-0.016458439,
-0.0030380564,
0.01964101,
-0.0074692997,
-0.009008625,
-0.020290514,
-0.056169134,
0.0069756764,
-0.029773278,
-0.015769966,
-0.02414857,
-0.026408846,
-0.016900102,
0.01133385,
0.018679744,
0.009047595,
0.014548897,
-0.008982644,
0.0155491335,
0.025265718,
0.00028598486,
0.0021612255,
-0.028318388,
-0.020563306,
0.00833314,
0.02256378,
-0.012587394,
-0.035696756,
-0.026058113,
0.01360062,
-0.0029974624,
-0.0012308107,
0.0059851822,
-0.011236425,
0.0119768595,
-0.0021011464,
-0.00045262332,
-0.005783836,
-0.00050498964,
-0.01641947,
-0.011216939,
-0.012184701,
-0.023174314,
-0.0031030069,
-0.0048972624,
0.0075667254,
-0.015977807,
-0.013431749,
-0.0068652607,
-0.008989139,
0.030916406,
-0.040061425,
0.032761,
0.001153682,
0.00913203,
0.021277761,
-0.01347072,
0.0018186121,
0.02548655,
-0.018731704,
0.0017861369,
0.0019338991,
0.004426372,
0.0011910285,
-0.022355938,
-0.0045919954,
-0.01358763,
-0.020329485,
-0.04536138,
-0.0014394639,
0.014380026,
0.013717531,
-0.012905651,
-0.024538273,
-0.014912619,
-0.0028497002,
-0.011015593,
0.025304688,
-0.019926792,
-0.01971895,
-0.023680927,
0.019017486,
-0.009411317,
-0.031020327,
0.04528344,
-0.036813904,
-0.014769728,
0.0026580964,
0.0046244706,
0.019420179,
-0.0024421362,
0.01281472,
-0.011665097,
-0.004968708,
-0.0037996003,
-0.018510872,
0.0022976215,
0.009404822,
0.057935786,
0.010963633,
0.009567198,
0.042997185,
0.015795946,
0.025798311,
0.012379552,
-0.0006162172,
0.0027344131,
0.019407189,
0.009580188,
0.023538036,
-0.004783599,
0.018393962,
-0.00024417305,
-0.0007899596,
0.012288622,
0.010853217,
-0.02696742,
-0.022849562,
-0.009300902,
-0.0074498146,
-0.015614084,
-0.0024924728,
0.003318967,
0.023512056,
-0.036735963,
0.002347958,
-0.0057611032,
-0.010424544,
0.002213186,
-0.013431749,
0.012912146,
-0.017757447,
0.012321097,
-0.026629677,
-0.008008389,
-0.018926555,
-0.03005906,
0.00061581127,
-0.010203713,
-0.0011017217,
-0.014730758,
0.02097899,
0.01508149,
-0.014743748,
-0.0004952471,
-0.02101796,
-0.034034025,
0.00032799967,
-0.0029016605,
-0.016159669,
-0.011035078,
-0.008592942,
-0.026201004,
-0.011593652,
-0.0074498146,
0.00045099956,
-0.019043466,
0.032916877,
-0.017952299,
0.0030575416,
-0.017419705,
0.0010424544,
0.014237135,
-0.017666517,
0.047231954,
0.020914039,
-0.008826763,
-0.023589997,
0.0167702,
0.0065534986,
0.013925373,
0.018822635,
0.018913565,
-0.0064235977,
0.003815838,
0.015834916,
0.020589286,
-0.025772331,
-0.039905544,
0.015588104,
-0.01667927,
0.00748229,
0.001581543,
-0.007690131,
-0.034008045,
-0.005449341,
-0.030968366,
0.0018770675,
-0.0071055773,
-0.025174787,
-0.00022489087,
0.009898446,
-0.038164873,
0.026733598,
0.008963159,
0.00673536,
-0.0034716006,
-0.008300665,
-0.024252491,
-0.01209377,
-0.0010919791,
0.017679507,
0.016016778,
-0.012236661,
0.018965526,
-0.009521733,
0.010073812,
0.017770438,
-0.036995765,
0.039931525,
0.011509216,
-0.02264172,
-0.025226748,
0.0025411856,
0.010515475,
0.008411081,
-0.023538036,
-0.009723079,
-0.020667227,
-0.0155491335,
0.031591892,
0.004806332,
-0.02416156,
-0.010177732,
-0.031981595,
-0.0007319102,
-0.009482763,
-0.025161797,
-0.010788267,
-0.038164873,
-0.009612664,
0.0033319572,
0.0049719554,
0.03356638,
0.01056094,
-0.015536143,
-0.011619632,
0.018783664,
-0.027720844,
0.023901759,
0.0075667254,
0.005361658,
-0.018406952,
0.015159431,
-0.0098919505,
-0.007203003,
-0.005225262,
0.012886166,
-0.018666754,
-0.020576296,
0.008800783,
0.014483946,
0.007833023,
0.0037216598,
0.01666628,
0.021901285,
-0.0029178981,
-0.015185411,
-0.0180822,
0.0005334054,
0.030240921,
-0.007060112,
0.022459859,
-0.023408135,
0.001391563,
-0.03798301,
0.014133214,
-0.0016757211,
-0.028266428,
0.021836335,
-0.007884983,
0.022329958,
-0.023745878,
0.020745168,
-0.007969419,
-0.014107234,
-0.031020327,
0.032397278,
-0.004744629,
-0.015432223,
0.0092879115,
0.009411317,
-0.009209971,
0.008378605,
-0.02255079,
-0.029123774,
-0.005118094,
-0.01967998,
-0.018380972,
-0.00027543042,
-0.0055630044,
0.036917824,
0.02847427,
-0.022940492,
-0.04084083,
-0.014496936,
-0.04229572,
-0.0015994044,
0.008878724,
0.025993163,
0.0037216598,
0.019277288,
0.0017049488,
0.026629677,
-0.005829301,
0.014847669,
-0.014717768,
-0.01352268,
0.002070295,
-0.0043451837,
0.027798785,
0.003611244,
-0.02707134,
-0.020745168,
0.022849562,
-0.010275158,
-0.02868211,
0.011807988,
-0.019303268,
0.021394672,
-0.020264534,
0.016224619,
0.008008389,
0.008755318,
0.011392306,
-0.010905177,
-0.0068782507,
-0.0032637592,
0.012710799,
-0.0028594427,
-0.00817726,
-0.025876252,
0.0071250624,
-0.0066769044,
-0.02104394,
-0.015237371,
0.037151646,
-0.009612664,
0.008755318,
0.01350969,
0.018354991,
0.031669833,
0.00981401,
0.00908007,
-0.021433642,
-0.0073978542,
-0.011249415,
0.009171001,
-0.011190959,
-0.023836808,
-0.036813904,
0.0006052568,
0.009229456,
-0.011002603,
-0.002477859,
-0.008969654,
-0.03141003,
-0.020186594,
0.03910016,
0.002864314,
-0.022797601,
-0.0066411817,
0.019290278,
-0.02995514,
-0.017263824,
-0.017224854,
-0.019654,
-0.026447816,
0.00207679,
-0.00203782,
-0.010054327,
0.017549606,
-0.0015182163,
-0.0050661336,
-0.01623761,
-0.008963159,
0.1778083,
-0.01635452,
-0.015367272,
0.01499056,
-0.0026499776,
-0.025928212,
0.03650214,
0.020069683,
0.0106129,
-0.010314128,
-0.0027636408,
0.009723079,
-0.016003788,
0.014522917,
0.031072287,
0.0037119172,
-0.047829498,
-0.0072939335,
0.0051083514,
-0.003374175,
0.0066574193,
-0.014808699,
-0.021771384,
-0.00091823674,
0.030630624,
0.00008798754,
-0.019056456,
-0.0061313207,
0.02696742,
-0.010846722,
0.001248672,
0.003530056,
0.023953719,
0.00407564,
-0.03003308,
-0.007332904,
0.007378369,
-0.011444266,
0.012925136,
-0.0112689,
-0.010301138,
0.0034098977,
-0.0034261353,
-0.010275158,
-0.009794525,
0.007846013,
-0.002341463,
-0.029487496,
0.007345894,
0.005449341,
-0.016016778,
-0.00095558324,
0.010060822,
0.012048305,
-0.029851219,
0.009235951,
0.0241096,
-0.017705487,
0.00032251948,
-0.00600142,
0.010216703,
0.0025557994,
-0.025265718,
0.01800426,
-0.020667227,
0.0150944805,
-0.0150685,
0.009846485,
-0.008034369,
-0.014003313,
-0.018965526,
-0.020888058,
-0.02860417,
0.027876725,
-0.03624234,
-0.03320266,
0.030500723,
0.0062742117,
0.011509216,
0.0182121,
0.010203713,
0.0027977398,
-0.017030003,
-0.021264771,
-0.02258976,
-0.015627075,
0.002979601,
0.032267377,
0.014847669,
-0.009060585,
-0.00018236863,
0.0030835217,
-0.0014248501,
-0.008917694,
0.010768781,
-0.0064235977,
-0.025291698,
0.019939782,
-0.0364242,
0.023667937,
-0.0057870834,
0.05094712,
0.03011102,
-0.005498054,
-0.005709143,
-0.016510399,
-0.014639827,
0.041152593,
0.024798075,
-0.0044426094,
-0.009690604,
-0.018874595,
0.0104829995,
-0.014535907,
-0.00563445,
0.00901512,
0.0036079965,
-0.017965289,
-0.0021904532,
-0.004147085,
-0.0003014106,
-0.042763364,
0.032994818,
0.033930104,
0.001113088,
0.00677433,
-0.03769723,
-0.00012472513,
-0.021667464,
-0.012223671,
0.013808462,
-0.02421352,
-0.026136054,
0.0130160665,
0.0055954796,
-0.0066022114,
-0.009989376,
-0.012022325,
0.009807515,
0.028812012,
-0.02260275,
-0.01825107,
-0.020485366,
0.011100029,
0.0044685896,
-0.014457966,
0.016172659,
0.0152503615,
-0.0077355965,
0.010762286,
-0.020628257,
0.020589286,
0.0068133003,
0.00083786057,
0.0042802333,
-0.010489495,
-0.008592942,
-0.05887107,
0.010664861,
0.014302085,
-0.0026321162,
0.0016854637,
0.028915932,
-0.023667937,
0.004656946,
0.0017747706,
-0.16242804,
0.019186357,
0.038346734,
0.00076397945,
0.013912383,
-0.012223671,
0.00082649424,
0.0150944805,
-0.000073272204,
-0.014393016,
0.03128013,
0.004432867,
-0.003088393,
0.0043614213,
-0.0033352047,
-0.013782482,
0.004117857,
0.04084083,
0.04372463,
0.013444739,
-0.00034870263,
-0.020875068,
0.017588576,
0.017978279,
-0.0037184122,
0.023226274,
-0.0075927055,
0.008826763,
0.010255673,
-0.0058357962,
-0.0011885929,
0.0022781363,
0.0085474765,
-0.018601803,
0.003312472,
0.005173302,
-0.0032881156,
-0.0004903758,
-0.012035315,
0.00027543042,
0.032111496,
0.044607956,
-0.018705724,
0.01966699,
-0.0021336216,
0.024979936,
0.020368455,
-0.012970601,
0.031773753,
-0.01812117,
0.017094953,
-0.0212258,
0.016497409,
-0.0058065685,
-0.020576296,
-0.0059429645,
0.018861605,
-0.010093297,
0.0040041944,
-0.008703358,
-0.0050271633,
-0.032293357,
0.026915459,
0.0023934233,
-0.0056182123,
-0.0038320755,
-0.025759341,
0.027642904,
-0.036761943,
-0.010567435,
-0.012022325,
0.0010059199,
0.023628967,
-0.017874358,
0.017744457,
-0.0024535025,
-0.021329721,
0.011963869,
-0.004744629,
0.017770438,
-0.00974906,
0.015782956,
-0.02400568,
-0.009651634,
-0.017198874,
0.0030088287,
0.020498356,
0.0049297377,
0.00031196504,
-0.0128407,
0.030448763,
-0.031202188,
0.0026499776,
-0.022992453,
-0.0028610665,
0.012619869,
0.0028399576,
-0.002044315,
0.0022683938,
-0.0054395986,
0.0024388887,
-0.029721318,
-0.03483941,
0.020485366,
0.026447816,
-0.0057188855,
0.009690604,
-0.0125679085,
0.040451128,
-0.021836335,
0.0005573559,
0.0010879197,
-0.0007899596,
0.0068457755,
-0.018874595,
0.05242799,
-0.019264298,
-0.0030218188,
0.028863972,
-0.008670882,
0.05112898,
-0.0075862105,
0.020420415,
0.007936943,
0.02403166,
0.005436351,
-0.110467695,
-0.021433642,
0.0014451471,
0.009827,
0.0053259353,
0.015743986,
-0.031747773,
0.014587867,
-0.0037443924,
0.04071093,
-0.014107234,
-0.012061295,
-0.018848615,
0.0051895394,
0.03652812,
-0.018329011,
0.0052512423,
-0.013191433,
-0.00012726226,
0.038242813,
-0.0033222146,
-0.01671824,
-0.015834916,
-0.01354866,
0.009716584,
0.005566252,
-0.040373188,
-0.013691551,
0.01285369,
0.0030997593,
0.014821689,
-0.0019452655,
-0.0060663703,
-0.026915459,
-0.01961503,
-0.0031663335,
-0.017536616,
-0.009703594,
0.0032897394,
-0.0037833627,
0.0066152015,
0.019238317,
0.020069683,
0.0064658155,
-0.0027652646,
-0.036787923,
-0.03502127,
0.03133209,
0.009521733,
-0.018601803,
-0.013652581,
-0.02409661,
-0.011658602,
0.0038320755,
-0.006530766,
-0.020251544,
0.0044491044,
-0.0022001958,
0.004702411,
0.00048996985,
-0.013301848,
0.017159903,
-0.03780115,
0.021654474,
0.024759104,
-0.014003313,
-0.014522917,
-0.019264298,
0.013418759,
-0.02998112,
-0.019446159,
-0.0013184937,
0.005355163,
0.008157775,
-0.029331615,
-0.008502011,
-0.03764527,
-0.010866207,
0.04052907,
-0.039593782,
0.015951827,
-0.008508506,
0.02992916,
-0.009606169,
0.01669226,
-0.005218767,
-0.007936943,
-0.019056456,
-0.002674334,
-0.0116715925,
-0.008761813,
0.032111496,
0.017224854,
-0.025226748,
0.017250834,
-0.006569736,
0.002294374,
0.0005053956,
0.014626837,
-0.007949933,
-0.02863015,
-0.002857819,
-0.035073232,
0.031150227,
0.002490849,
-0.01818612,
-0.006339162,
-0.0014857411,
0.02112188,
-0.008729338,
-0.0116715925,
0.02696742,
-0.013223908,
0.04393247,
-0.012593889,
-0.024655184,
-0.01282771,
-0.032033555,
-0.000069466514,
0.015640065,
0.02717526,
0.0044978173,
0.0058942516,
0.019887822,
0.027902706,
-0.0019062952,
-0.008099319,
0.0021872057,
0.008300665,
-0.003299482,
-0.012373057,
-0.008982644,
0.01810818,
-0.01678319,
-0.017341765,
0.0013128106,
0.00071242504,
-0.012938126,
-0.011580662,
0.021836335,
0.021927265,
0.014509927,
-0.006884746,
0.0069886665,
0.0074433195,
-0.00339366,
0.0033238383,
0.0012137612,
-0.023758868,
-0.0046601933,
0.008456546,
0.019861842,
0.011022088,
0.008027874,
0.011288385,
-0.0241096,
-0.010340109,
0.015575114,
0.0075992006,
0.019900812,
-0.018757684,
-0.0018640774,
0.020173604,
0.0006182469,
-0.010658366,
0.0023089878,
0.007183518,
-0.019108417,
-0.0049362327,
-0.0005468014,
0.0130160665,
0.0013087512,
-0.0015539391,
-0.019446159,
-0.0062417365,
0.0038028478,
-0.00203782,
0.00414059,
-0.017484656,
0.009209971,
0.001208078,
0.04824518,
-0.0038548082,
0.024603223,
-0.0072874385,
0.0069821714,
0.040139366,
0.018627783,
-0.015977807,
-0.0015019787,
0.011509216,
0.028110547,
-0.008917694,
0.010353099,
0.014003313,
0.0068327854,
0.0007018706,
0.03320266,
0.012249651,
0.012502958,
0.03473549,
0.027331142,
0.003692432,
-0.00025310373,
-0.023862788,
-0.029123774,
-0.022070156,
-0.015432223,
-0.008274685,
-0.03252718,
0.002945502,
0.010937653,
0.015640065,
0.010008861,
-0.008722843,
0.00094340503,
-0.015536143,
0.026265955,
0.00080092,
-0.0023853045,
-0.015640065,
0.017952299,
-0.009320387,
0.0069821714,
0.0056182123,
-0.014029293,
0.02269368,
0.012983591,
0.006517776,
0.00013964342,
0.051648583,
-0.022758631,
0.007917458,
0.007807042,
-0.02399269,
0.009125535,
0.009398327,
-0.027980646,
0.0015036025,
-0.0003454551,
0.0004093907,
0.06495044,
-0.01674422,
-0.008099319,
0.006456073,
-0.019965762,
0.022226037,
0.039593782,
-0.005088866,
0.008540981,
-0.02546057,
0.010580425,
0.0006888805,
0.010970128,
-0.024707144,
-0.001765028,
0.020667227,
0.011450761,
0.028708091,
0.000006035189,
-0.023330195,
0.01130787,
-0.011730048,
0.026408846,
0.025408609,
-0.041646216,
-0.018419942,
-0.010372584,
0.008437061,
-0.0022213047,
-0.02247285,
-0.017224854,
0.0067288647,
-0.03151395,
0.006884746,
0.0147957085,
-0.025720371,
-0.013626601,
-0.019926792,
0.010989613,
0.0030997593,
0.014198164,
-0.014587867,
-0.029383576,
0.0027506507,
-0.019381208,
-0.015354282,
-0.0026012647,
-0.050739277,
-0.026019143
] |
BACKGROUND Growth arrest-specific 5 (GAS5) was reported to be implicated and aberrantly express in multiple cancers. However, the expression and mechanism of action of GAS5 were largely poor understood in endometrial carcinoma. RESULTS According to the result of real-time reverse-transcriptase polymerase chain reaction (RT-PCR) and flow cytometry analysis, we identified that GAS5 was down-regulated in endometrial cancer cells and stimulated the apoptosis of endometrial cancer cells. To investigate the expression of GAS5, PTEN and miR-103, RT-PCR was performed. And we found that the expression of PT | [
-0.044903252,
-0.011548432,
0.0030467713,
-0.03800316,
-0.025783157,
0.0046154223,
-0.034579456,
0.0032689832,
-0.018948909,
-0.013628993,
0.014221558,
0.0011563246,
0.00001711597,
0.0014814123,
-0.026770767,
0.03874058,
0.03247256,
-0.010508151,
-0.016341623,
0.002279729,
0.007841609,
0.012562376,
-0.020647595,
0.0028048072,
-0.0026879404,
0.018935742,
0.006152799,
-0.04590403,
-0.0038615481,
-0.032577902,
-0.003023727,
-0.0060869586,
-0.004322432,
-0.022122424,
-0.014761451,
-0.004799776,
-0.0033545757,
-0.009560048,
0.022175096,
-0.006050746,
0.0077230963,
0.00506643,
0.01219367,
0.023149537,
-0.018962078,
0.0016558898,
0.015920244,
-0.023347057,
-0.019620482,
0.0063404446,
0.006396409,
-0.008921394,
-0.03302562,
0.00018569092,
-0.015762227,
0.0019850924,
-0.0029233203,
0.029285874,
-0.009546879,
-0.0016575358,
-0.01441908,
-0.00064276834,
-0.03571191,
0.03642299,
0.010922947,
0.0020772691,
-0.027679365,
0.005988198,
0.014774619,
0.0012164041,
0.029891608,
0.027416004,
-0.009757569,
0.0127138095,
0.013628993,
-0.034000058,
-0.012819154,
-0.010468647,
0.009362525,
0.01260188,
0.021635203,
-0.0017776948,
0.00506643,
0.017605763,
-0.00003420622,
0.0062054717,
-0.006337153,
0.017724276,
0.01208174,
0.011462839,
0.031656135,
0.035817258,
0.022820333,
0.017908629,
-0.020147206,
0.03529053,
-0.006488586,
0.030471005,
-0.00459567,
-0.049986143,
0.016130934,
-0.0040261494,
-0.0028574797,
-0.009816825,
0.0059684454,
-0.015604209,
0.010784682,
-0.0010616789,
0.010060435,
-0.002062455,
-0.026349386,
0.006768408,
-0.008539519,
-0.0066005145,
0.017737443,
0.0024640823,
0.03571191,
0.012002732,
-0.037423767,
-0.008868721,
-0.005922357,
0.0141820535,
0.035079844,
-0.02583583,
0.020213047,
-0.011745953,
-0.011133636,
0.012055404,
-0.014089877,
-0.0061857193,
0.011778873,
0.022201432,
0.01344464,
0.0053824647,
-0.013227366,
-0.005826888,
-0.030418333,
-0.020647595,
-0.0310504,
-0.048853684,
-0.004737227,
0.024492683,
-0.0031850364,
-0.001693748,
-0.009968258,
-0.0021398177,
0.011923723,
0.018395849,
0.0049018287,
0.025822662,
0.00044154318,
-0.029022513,
0.0035257612,
-0.009000403,
-0.00891481,
-0.019041086,
0.008282741,
0.027205314,
-0.03629131,
-0.024347834,
0.010185532,
0.018580202,
0.016051926,
0.013484144,
0.016446969,
0.03036566,
0.0050137574,
0.018343177,
-0.009336189,
-0.028153418,
0.0022435165,
-0.0024904187,
-0.03070803,
0.006524798,
-0.012417527,
0.018606538,
-0.016381128,
0.018356344,
-0.0022287024,
-0.0135104805,
-0.011153389,
0.01671033,
-0.022201432,
-0.010007763,
-0.014353239,
0.0057215434,
0.01622311,
-0.006422745,
-0.010429142,
-0.024255658,
0.0046318825,
0.020792445,
0.011666945,
-0.0012657845,
-0.61900645,
-0.023689428,
-0.0099550905,
0.010712257,
0.010172364,
0.038450878,
0.021740548,
-0.0029957448,
-0.037818808,
-0.0034665049,
-0.035264198,
0.027416004,
-0.00794037,
-0.002636914,
-0.010014347,
-0.03523786,
-0.032735918,
-0.011831546,
-0.0011225813,
0.01789546,
-0.02270182,
-0.0035817258,
-0.026415227,
0.02075294,
0.012970587,
0.034974497,
0.020436905,
-0.021187488,
0.01657865,
0.036396652,
-0.02681027,
0.035343204,
-0.0077955206,
-0.0026039935,
0.04645709,
-0.00030410103,
-0.01302326,
0.021411346,
0.006287772,
0.03913562,
-0.01316811,
0.0005563526,
0.01657865,
-0.0073148846,
-0.01998919,
0.020278888,
0.009178172,
-0.0049775452,
0.014458584,
0.008875306,
0.013411719,
0.022846669,
-0.020015527,
-0.0109295305,
-0.0010411036,
0.033367988,
0.010192117,
-0.0170527,
-0.0020986674,
0.0062021795,
0.017158046,
0.021608867,
-0.009856329,
-0.013378799,
-0.023083696,
0.029838936,
-0.01539352,
0.008862138,
0.005784092,
0.016842011,
0.011238981,
0.028732814,
0.00064276834,
0.011555016,
0.027073633,
0.054568645,
-0.019897014,
0.022728156,
0.0069725136,
-0.0042862194,
0.017605763,
-0.021635203,
-0.03800316,
0.01817199,
0.0056853313,
0.013451223,
-0.03879325,
0.004496909,
0.016723499,
0.019278113,
0.021161152,
-0.011001956,
-0.020344729,
-0.017750612,
0.0069395937,
0.008315661,
-0.0018106151,
0.022609644,
-0.0043882723,
-0.010073603,
-0.015788563,
-0.025388114,
0.015749058,
0.012180501,
0.012213421,
0.0119171385,
-0.042322304,
-0.010942698,
0.02548029,
-0.0069198413,
-0.006488586,
0.024835054,
0.01908059,
-0.01929128,
-0.0060836663,
-0.02681027,
0.018198326,
0.010494983,
-0.01859337,
-0.03515885,
0.007262212,
-0.016407464,
0.011745953,
0.003157054,
0.01567005,
0.013905523,
0.007281964,
-0.018158823,
0.0099419225,
-0.005046678,
0.0000036681672,
-0.01083077,
0.016091429,
-0.013549984,
0.014682442,
-0.020818781,
0.022543803,
-0.00076580787,
-0.0014295628,
-0.0407948,
-0.015591041,
0.0016641198,
0.023939623,
-0.00800621,
0.010560824,
0.004691139,
-0.023860615,
0.0007374141,
0.021951238,
0.023873782,
-0.006992266,
-0.009211092,
0.029127857,
0.02492723,
-0.0022418706,
-0.010218453,
-0.005807136,
-0.011357495,
-0.0057445876,
-0.0035916017,
-0.007466318,
0.022188265,
-0.009099163,
-0.017605763,
-0.002294543,
-0.024782382,
-0.010159196,
-0.0067552403,
-0.01441908,
-0.022965182,
-0.02263598,
-0.0179613,
0.0032722752,
-0.0002845546,
0.016209943,
-0.007472902,
0.004671387,
0.0033035495,
-0.0037232828,
-0.013945027,
0.03184049,
-0.02242529,
-0.019725828,
0.004605546,
0.03760812,
0.024532188,
0.025888503,
0.003129072,
-0.012832322,
0.0331573,
-0.021608867,
0.017921796,
-0.02883816,
0.015340847,
0.012022484,
-0.017882293,
0.037160404,
0.0072556282,
-0.00028393735,
0.03579092,
0.0027521348,
-0.016407464,
-0.011344326,
0.008895058,
0.014761451,
-0.015261838,
0.0014805893,
-0.016736668,
0.0028393737,
0.001450961,
-0.0073083006,
0.016183605,
-0.0034533367,
0.020436905,
-0.011311406,
-0.028943503,
-0.010047267,
-0.020068198,
-0.011713034,
-0.016986862,
0.0033249476,
0.017381905,
0.006860585,
0.0014781202,
-0.014708778,
0.011166557,
0.01761893,
0.004859032,
-0.0023587376,
-0.020292057,
-0.002780117,
0.018790891,
0.004852448,
0.006633435,
0.013280038,
-0.00021583354,
0.024782382,
-0.004263175,
0.043481097,
-0.012022484,
-0.020318393,
-0.000839467,
0.0046812627,
-0.005800552,
-0.0030533553,
-0.025572468,
0.011396999,
-0.00030533553,
-0.006067206,
0.005718251,
0.0071897875,
0.029127857,
-0.014958972,
0.014642937,
0.002538153,
-0.006402993,
0.0024245782,
0.021411346,
0.03718674,
0.01838268,
0.021134816,
-0.0010048914,
-0.001195006,
-0.0057215434,
-0.01277965,
0.019910181,
0.031445444,
-0.00727538,
-0.0054022167,
-0.000420145,
0.0027175685,
0.0071832035,
0.031313762,
-0.030918721,
0.0058960207,
-0.0141820535,
0.009790489,
0.018264167,
0.0053429604,
0.004934749,
-0.0077362643,
-0.03310463,
0.03963601,
0.024071304,
-0.01844852,
-0.0047668554,
-0.022662316,
-0.013438055,
-0.0041479543,
-0.013108852,
-0.00041932196,
0.023281217,
0.019541474,
0.014774619,
-0.015841234,
-0.0086712,
-0.007459734,
-0.011680113,
0.017197551,
0.013536816,
0.008559271,
-0.0246507,
0.00410845,
-0.007222708,
0.04011006,
0.0047668554,
0.0005312509,
-0.01511699,
0.0038352117,
-0.019883845,
-0.006482002,
0.0030434793,
0.0009209446,
0.0010921301,
-0.0059980736,
0.0070251864,
0.01755309,
-0.0022501007,
0.028153418,
0.010685921,
-0.023110032,
-0.018013973,
-0.015933413,
-0.016051926,
0.0164338,
0.03036566,
-0.008730456,
-0.005092766,
0.008677784,
0.0041578305,
-0.012154165,
-0.014537592,
0.0073083006,
-0.009309853,
-0.0063536125,
0.005856517,
0.007690176,
-0.017566258,
0.02075294,
0.017869124,
0.004510077,
-0.002401534,
-0.019409792,
-0.0047964836,
0.019738996,
-0.0054680575,
0.020489577,
0.027811047,
0.012931083,
-0.007229292,
0.02382111,
0.0138528505,
0.008546103,
-0.003601478,
-0.018975245,
0.023057358,
-0.006011242,
0.008559271,
-0.014932636,
-0.010323797,
0.015512032,
-0.016828844,
0.0021118354,
0.0017892169,
0.0015456068,
0.022807166,
0.014577097,
0.0029414264,
0.017368736,
-0.008664615,
-0.004592378,
0.01956781,
0.010264541,
-0.018119318,
0.02179322,
-0.033367988,
-0.021766884,
0.000004545827,
0.0065708864,
0.01256896,
-0.0054614735,
0.0023636755,
-0.021279665,
-0.0173424,
0.0014377929,
-0.021543026,
-0.0031488242,
-0.023360226,
-0.0005942109,
-0.003634398,
0.003030311,
-0.021845894,
-0.008901642,
-0.011574768,
0.0036640265,
-0.03874058,
-0.028443117,
0.011094132,
0.011054628,
0.008802881,
0.017210718,
-0.014827291,
0.009592967,
0.025269601,
-0.0046812627,
-0.01782962,
0.004098574,
-0.04263834,
0.006748656,
-0.004299388,
0.002174384,
-0.024361001,
-0.034869153,
0.008414422,
0.002661604,
-0.017869124,
0.024756046,
-0.020858284,
-0.017869124,
0.030102298,
0.015498864,
0.01671033,
0.0077955206,
0.0042532994,
-0.0044014407,
-0.03371036,
-0.017500417,
-0.027942728,
-0.008750209,
-0.019041086,
0.006867169,
0.0094612865,
-0.014537592,
-0.0039306805,
0.030339323,
-0.008098387,
-0.022096088,
0.002401534,
0.010508151,
0.029865272,
0.0024525602,
0.022161927,
-0.008421006,
-0.006383241,
-0.0025266309,
-0.0051191025,
0.032709584,
-0.002648436,
0.0009505729,
0.010053852,
0.0019982606,
-0.018790891,
0.000023057051,
-0.007690176,
-0.009276933,
0.03421075,
0.013108852,
-0.02528277,
-0.017013198,
-0.0031587002,
-0.014945804,
0.00794037,
0.00579726,
-0.007756016,
-0.025625141,
0.007196372,
-0.005086182,
-0.012279262,
0.01713171,
-0.031629797,
-0.02382111,
0.025717318,
-0.0003020435,
0.0010402807,
-0.0059816134,
0.01755309,
-0.020305224,
0.0075321584,
-0.019515138,
-0.026849775,
-0.0034599206,
-0.0022583308,
0.02388695,
0.010231621,
0.028258763,
-0.004460697,
0.011146804,
0.027205314,
0.0019571101,
0.011206061,
-0.015959749,
0.012358271,
-0.0010674399,
0.028811824,
0.014906299,
-0.018935742,
0.020226216,
-0.012680889,
0.0068408325,
0.009790489,
-0.027073633,
-0.0024328083,
0.0139977,
-0.03900394,
-0.044323854,
-0.00026315643,
-0.015419856,
-0.0010015994,
-0.042427648,
-0.021108478,
0.008374917,
0.00082917936,
0.019264944,
0.0009382278,
0.0038977603,
-0.04358644,
0.033868376,
-0.019857509,
0.010508151,
-0.008579023,
-0.016907852,
0.026915615,
-0.026349386,
0.01797447,
-0.009415198,
0.022096088,
-0.007328053,
-0.016894683,
-0.0009900772,
0.0018616414,
-0.018935742,
-0.021766884,
0.02361042,
-0.03676536,
-0.037739802,
0.017724276,
0.002776825,
-0.044113167,
-0.008019378,
0.021134816,
-0.025796326,
0.021253329,
-0.015591041,
-0.010488399,
0.026165033,
-0.006590639,
0.023149537,
0.0016509517,
0.030286651,
0.009296685,
-0.005928941,
-0.031182082,
-0.0078284405,
0.020081367,
0.007611167,
0.01782962,
0.017013198,
0.0074136453,
-0.027126305,
-0.008223484,
0.027863719,
-0.009513959,
-0.0071897875,
0.012088324,
0.009382278,
-0.0164338,
-0.017842788,
-0.01117314,
-0.03629131,
0.0047174753,
-0.006531382,
0.0029990368,
-0.008855553,
-0.023215376,
-0.029233202,
0.028732814,
-0.004684555,
0.008493431,
-0.0049808375,
-0.015564705,
-0.01602559,
-0.025928007,
0.0030599395,
0.00036500354,
-0.013734338,
0.014458584,
-0.007130531,
0.017750612,
0.028706478,
-0.01414255,
-0.013892355,
-0.013773843,
-0.0069264253,
0.033684023,
0.009118916,
-0.014340071,
-0.0011941829,
0.0031652842,
0.047747564,
0.0009390508,
0.0007723919,
-0.02883816,
-0.018053478,
-0.004694431,
0.019554643,
0.01117314,
-0.0050302176,
0.0025611972,
-0.031313762,
0.0024542063,
-0.026086025,
-0.005662287,
0.02611236,
-0.043007046,
-0.014326903,
-0.006287772,
0.011212645,
0.021964407,
0.014906299,
-0.008789713,
-0.00038722472,
0.047299847,
-0.017474081,
0.014353239,
0.0051553147,
-0.013905523,
-0.0049281646,
0.019106926,
0.0038352117,
-0.03421075,
0.025809495,
-0.027073633,
-0.034316093,
-0.031208418,
-0.018435353,
0.01984434,
0.0059256493,
-0.0056129065,
0.005171775,
0.018224664,
-0.007756016,
-0.0130298445,
-0.00004292495,
0.01357632,
-0.011877635,
0.015538369,
0.019712659,
-0.009909002,
0.004799776,
-0.002054225,
-0.012061988,
0.0020805614,
-0.0062054717,
-0.018224664,
-0.019673156,
-0.005043386,
-0.017790116,
0.01671033,
-0.012371439,
-0.009744401,
-0.008243237,
0.025374947,
0.024703372,
-0.015604209,
-0.014827291,
-0.007933786,
-0.0037858314,
-0.00036315178,
-0.014642937,
-0.0096127195,
-0.012680889,
-0.015512032,
-0.03447411,
-0.013563152,
-0.024176648,
0.018764555,
-0.0070976107,
-0.031735145,
-0.027574021,
0.011192893,
-0.02910152,
-0.014893131,
-0.0018994998,
0.009204509,
0.0027883472,
0.024848223,
-0.028680142,
-0.012121244,
0.008559271,
-0.0068276646,
-0.011456255,
-0.014208389,
0.020581754,
-0.019449297,
0.01846169,
0.0023554456,
-0.00051232177,
-0.028443117,
0.015064317,
0.011462839,
-0.010936115,
0.024084471,
-0.021200655,
0.009362525,
-0.03473747,
-0.015564705,
-0.008579023,
0.0043619364,
0.011080964,
-0.013602657,
0.008052299,
0.03824019,
0.01427423,
-0.024979902,
0.02166154,
0.0025957634,
-0.0052540754,
0.010554239,
-0.0059783217,
-0.026138697,
0.0045067854,
0.013945027,
0.019818004,
0.02382111,
0.007841609,
0.02206975,
0.006139631,
-0.01316811,
-0.017434577,
-0.014261062,
0.004618714,
0.0077691847,
0.0164338,
0.0069132573,
-0.0279954,
-0.0013744214,
0.0034302925,
-0.014484921,
-0.013345879,
0.00412491,
-0.0061791353,
-0.0179613,
0.030734368,
-0.013391967,
0.0010254665,
-0.00071354694,
0.021990743,
-0.019449297,
-0.0069725136,
-0.0027126304,
-0.00070367084,
-0.030102298,
-0.01677617,
-0.016486473,
0.0035718495,
0.02695512,
-0.014089877,
-0.00435206,
-0.0038088756,
0.013628993,
0.21806389,
-0.0049643773,
0.0016344916,
0.013115437,
0.0131944455,
-0.0029414264,
-0.0022287024,
-0.0077296803,
-0.018672379,
0.0019011458,
0.009520543,
0.0042302553,
-0.0046351743,
-0.002399888,
0.020766107,
-0.008921394,
-0.023017855,
-0.010238205,
-0.024044968,
-0.009606136,
0.00922426,
0.010712257,
0.023584083,
0.010659585,
0.025611972,
0.003033603,
-0.015749058,
0.00042076223,
0.024479516,
-0.01622311,
-0.030760704,
0.011752537,
-0.0019735703,
-0.01441908,
0.0042467155,
0.017434577,
-0.0051191025,
0.0073214686,
-0.010995371,
-0.0075124064,
-0.004111742,
0.03231454,
0.0012666075,
0.0037726632,
-0.016736668,
-0.008816049,
-0.014853627,
-0.018988414,
0.0043619364,
0.0010098293,
-0.047168165,
0.0039076363,
0.017921796,
0.010508151,
-0.01937029,
-0.002669834,
-0.009085995,
0.012127829,
-0.018422185,
0.015433024,
0.004559458,
0.018646043,
-0.006748656,
0.015709555,
-0.033315316,
0.020845117,
-0.0038845923,
0.0013357401,
0.0066663553,
-0.005543774,
0.005191527,
-0.0041611227,
-0.003132364,
0.019475633,
-0.040768467,
-0.011574768,
0.025928007,
0.040004715,
0.02765303,
0.024979902,
0.040294413,
0.0022204723,
-0.043639112,
-0.0062219314,
-0.014287398,
-0.022056583,
0.01260188,
0.017500417,
-0.026204538,
-0.013003508,
0.0043323077,
-0.015130158,
0.013747506,
0.00314224,
0.022767661,
-0.018922573,
-0.008183979,
-0.005303456,
-0.00120982,
-0.025611972,
-0.009573216,
0.068158135,
0.007881113,
0.009948507,
-0.0027965773,
0.013497312,
-0.025888503,
0.019818004,
0.003957017,
-0.007894281,
0.0101065235,
-0.0066926917,
0.010975619,
0.0010608558,
-0.024058135,
-0.003749619,
0.015077485,
-0.004371812,
0.017592594,
-0.02096363,
-0.017579425,
-0.02667859,
0.008486846,
0.024189817,
0.0026830023,
0.0041940426,
-0.026718093,
0.0009876082,
0.0086712,
-0.036185965,
0.0036673185,
-0.0077955206,
-0.015064317,
0.0044343607,
-0.010699089,
-0.0060935426,
0.00021377602,
0.005191527,
-0.018211495,
0.018856732,
-0.009415198,
0.0051487307,
0.012391191,
0.028153418,
-0.0033397616,
-0.011785458,
0.032814927,
0.0077626,
-0.034948163,
-0.025151089,
-0.03529053,
-0.0064523737,
-0.0130430125,
0.01497214,
0.026270378,
-0.017632099,
-0.0346848,
-0.021108478,
0.013247118,
0.014076709,
-0.027047297,
0.003631106,
0.032419886,
-0.0033660978,
-0.0012838907,
-0.0075387424,
-0.16507542,
0.0033364696,
0.024281994,
-0.012970587,
0.015275007,
0.03036566,
-0.005909189,
-0.010146028,
-0.018580202,
-0.0023044192,
0.03810851,
0.010837354,
-0.017869124,
-0.00095468794,
0.0016023943,
0.012173917,
-0.014840459,
0.018975245,
0.031577125,
-0.00078556,
0.011640608,
-0.02994428,
-0.00035800796,
-0.0016583587,
-0.019330785,
0.01789546,
-0.00023229368,
-0.009520543,
-0.017987637,
-0.0037792474,
-0.024795549,
0.0019933225,
0.014998476,
0.014076709,
0.0022237645,
0.008829217,
-0.01180521,
-0.019936517,
-0.03015497,
0.009000403,
0.034921825,
0.021385008,
0.0059849056,
-0.008335413,
-0.002661604,
0.03210385,
0.009454702,
-0.014642937,
0.04158489,
0.0068408325,
0.032972947,
-0.036739025,
0.025322273,
0.028416779,
-0.0025776573,
0.019436128,
0.022873005,
0.014353239,
0.003976769,
-0.0076704235,
0.00459567,
-0.013918691,
0.051092263,
0.029285874,
-0.00054195,
-0.042875364,
-0.008072051,
0.013036428,
-0.0279954,
-0.0077889366,
-0.02681027,
-0.033209972,
0.009494207,
-0.025651477,
0.031735145,
-0.013240534,
-0.014866795,
0.019659987,
0.013892355,
0.0069659296,
-0.009718064,
-0.007499238,
-0.034790143,
-0.015828067,
-0.008236652,
0.01518283,
0.022530634,
0.008822633,
-0.004816236,
-0.0026286838,
0.03795049,
-0.007347805,
-0.011449671,
0.013062764,
0.02339973,
0.011080964,
0.0015900492,
-0.007953538,
-0.022530634,
-0.014642937,
0.008012795,
-0.012733562,
0.0051223943,
0.007683592,
0.02346557,
0.0020673932,
-0.009026739,
-0.0065577184,
0.057412956,
-0.017776947,
-0.036818035,
0.0023439236,
-0.007709928,
0.014050373,
0.00982341,
0.029628245,
0.004503493,
0.0018846856,
0.00459567,
-0.02318904,
0.046299074,
-0.003145532,
0.014234726,
0.029312212,
0.035764586,
-0.03760812,
-0.1150366,
-0.039504327,
0.024742877,
0.028390443,
-0.020581754,
0.021529859,
-0.007854777,
0.034790143,
-0.02041057,
0.034000058,
-0.016868347,
-0.006159383,
-0.008269573,
-0.0071700355,
0.01497214,
-0.0035224692,
0.0012805986,
-0.020831948,
-0.010837354,
0.021622036,
-0.0022385786,
-0.010962451,
0.00405907,
-0.042243294,
0.015972916,
-0.024716541,
-0.019199103,
0.00794037,
0.003138948,
-0.011396999,
-0.0011958289,
0.007611167,
0.025822662,
-0.021990743,
-0.015288175,
-0.030655358,
-0.009724649,
-0.022477962,
0.03168247,
0.0017464205,
-0.0059816134,
0.026388891,
0.010732009,
0.0074070613,
0.017302895,
-0.030128634,
-0.031103075,
0.0007024363,
-0.004207211,
-0.020581754,
-0.0565702,
-0.019146431,
-0.011555016,
-0.0055931546,
0.0038121676,
-0.013154941,
0.033868376,
0.040057387,
-0.015354015,
-0.003499425,
-0.00070819736,
-0.0027109846,
-0.0028113914,
0.0014657752,
0.011008539,
-0.0045265374,
-0.0051125186,
-0.029443892,
0.027416004,
-0.006531382,
-0.026428396,
-0.0014723592,
-0.0071041947,
-0.009553463,
-0.031524453,
0.0018484733,
0.0026879404,
-0.011785458,
0.02382111,
-0.02521693,
-0.016051926,
-0.03310463,
0.026968287,
-0.0068144966,
0.04240131,
-0.024268825,
0.0077823526,
-0.021424513,
-0.0036771945,
-0.017118542,
-0.007143699,
0.03139277,
-0.0017085621,
-0.028258763,
-0.012029068,
0.012707225,
-0.013615825,
0.0037002387,
-0.0009522189,
0.0070581064,
-0.013161525,
-0.012483368,
-0.07126581,
0.0013530232,
-0.0026007015,
0.017908629,
0.005431845,
-0.0197785,
0.0066038067,
0.0028031613,
-0.0010024223,
-0.014024036,
-0.01037647,
0.021345505,
0.00842759,
-0.02528277,
-0.019409792,
-0.0033150716,
0.032209195,
0.020436905,
0.007216124,
0.03310463,
0.01372117,
-0.004233547,
-0.012759898,
0.0031866825,
0.00047528645,
-0.005524022,
-0.016367959,
0.026704926,
-0.017105374,
-0.0075058225,
0.010251373,
-0.031024065,
-0.01316811,
-0.012884995,
-0.0070581064,
-0.007690176,
-0.01204882,
0.029048849,
0.026994623,
0.009296685,
-0.011067796,
-0.01469561,
0.011311406,
-0.00265502,
0.017105374,
0.011008539,
-0.020818781,
0.0043191398,
0.008355165,
-0.007012018,
0.03294661,
0.0018879777,
-0.017632099,
-0.024729708,
-0.0127006415,
-0.0032311247,
-0.020529082,
0.0039965212,
-0.040083725,
0.0052507836,
0.013128605,
0.012680889,
0.024716541,
0.018606538,
0.027310658,
0.018988414,
-0.03739743,
-0.027099969,
0.004582502,
-0.04519295,
-0.0203974,
-0.027916392,
0.018119318,
0.010811018,
0.0034204163,
0.013411719,
-0.023031022,
0.023913287,
-0.007466318,
0.039794028,
0.011765705,
0.021464018,
-0.023728933,
0.0057116672,
0.047931917,
0.016183605,
-0.010369886,
-0.002287959,
-0.014761451,
0.01713171,
-0.0017464205,
0.025625141,
-0.0038319197,
0.010567408,
-0.0076704235,
0.02736333,
-0.009704896,
0.0030368953,
0.009882666,
0.028864495,
0.0017019782,
0.011706449,
-0.015709555,
-0.004223671,
0.00435206,
0.015709555,
-0.043059718,
-0.014392744,
-0.0014904654,
-0.018751388,
0.017000029,
0.0035619736,
0.0078284405,
0.010514735,
0.0027356746,
0.009974843,
0.00529358,
-0.01677617,
-0.003598186,
0.033921048,
0.0041150344,
-0.0053561283,
0.00852635,
0.014432248,
0.035474885,
0.008072051,
0.026191369,
-0.024966735,
0.037134066,
-0.030128634,
0.012641385,
-0.0053660045,
-0.047668554,
-0.025901671,
0.007953538,
0.007347805,
0.013800179,
0.021161152,
-0.011910555,
0.10218453,
0.0032113725,
-0.015709555,
-0.0037858314,
0.002753781,
0.017539922,
0.013905523,
0.0049940054,
-0.0062021795,
-0.032340877,
0.0065675946,
-0.01678934,
0.012661137,
-0.011206061,
-0.018027142,
0.008322245,
0.0020739771,
0.00071519293,
0.0060869586,
0.025045743,
0.028021736,
-0.021147983,
0.0007123124,
0.035527557,
-0.03684437,
0.0047701476,
0.03202484,
0.027547685,
0.014445416,
-0.025177425,
0.018922573,
0.009665392,
-0.033262644,
-0.008065467,
0.014616601,
-0.01107438,
-0.008500014,
-0.016446969,
0.037371095,
-0.0016394296,
0.013536816,
0.0017925089,
-0.016894683,
-0.018132487,
0.018369513,
-0.002661604,
0.014774619,
-0.006985682,
-0.004911705
] |
Podocyte dysfunction, represented by foot process effacement and proteinuria, is often the starting point for progressive kidney disease. Therapies aimed at the cellular level of the disease are currently not available. Here we show that induction of urokinase receptor (uPAR) signaling in podocytes leads to foot process effacement and urinary protein loss via a mechanism that includes lipid-dependent activation of αvβ3 integrin. Mice lacking uPAR (Plaur−/−) are protected from lipopolysaccharide (LPS)-mediated proteinuria but develop disease after expression of a constitutively active β3 integr | [
-0.018944625,
-0.007381547,
0.0100840805,
-0.018151345,
-0.011388288,
0.036141343,
-0.028907696,
0.0025075746,
-0.037969925,
-0.006245407,
0.01848748,
0.017788317,
0.023462294,
0.0084034,
-0.0070454106,
-0.01403704,
0.017116046,
-0.0011378204,
0.019240426,
0.0044672475,
-0.017626973,
0.016793355,
-0.005243722,
-0.019119415,
-0.017479073,
0.00049201905,
0.011650474,
-0.059697755,
-0.022978257,
-0.03544218,
-0.0096336575,
-0.0061109527,
-0.0172505,
0.0019243787,
0.0004705904,
-0.0012327788,
0.0071731424,
0.010373157,
0.020921106,
-0.014131158,
0.004450441,
9.8477344e-8,
0.0071664196,
-0.016860582,
-0.009573153,
-0.0042991797,
0.0131496405,
0.0049075857,
-0.025142973,
0.011475683,
0.014615194,
-0.00709247,
-0.00019411855,
-0.017411845,
0.004860527,
-0.0123832505,
0.0075496146,
0.018084116,
0.0069445698,
-0.019778242,
-0.009492481,
0.007831969,
-0.02804719,
-0.00045714498,
-0.012389973,
0.030117786,
-0.0065109544,
0.0046050632,
0.006245407,
-0.02409423,
0.05074309,
0.024363138,
-0.026326172,
-0.030090895,
0.009667272,
-0.035307728,
-0.012147956,
0.0075227236,
-0.002310935,
0.015731165,
-0.000080882724,
-0.0040941364,
-0.0056706145,
0.021364804,
0.005919355,
-0.01403704,
0.008793318,
0.025828691,
-0.0074622193,
-0.0055529666,
-0.0086992,
0.025640454,
0.01542192,
0.008168105,
-0.01984547,
0.01618831,
-0.001517654,
0.02533121,
0.013203423,
-0.023408512,
-0.0018252186,
0.004292457,
-0.0127530005,
-0.023260612,
-0.02093455,
0.0021142955,
-0.005778178,
0.0001435931,
3.627249e-7,
0.006299189,
-0.014628639,
0.046037186,
0.0060571707,
-0.02125724,
0.020544633,
-0.025909364,
0.022400104,
0.021875732,
-0.025089191,
-0.0077714645,
0.021875732,
0.01954967,
0.022695903,
-0.014870657,
0.028585006,
0.0010605091,
-0.004601702,
0.011495852,
-0.01571772,
-0.0018739583,
0.0123563595,
0.014077376,
0.02733458,
-0.0024016919,
-0.015193348,
0.008107601,
-0.029472405,
-0.0082555,
-0.028611897,
-0.026675753,
0.004789938,
0.021956405,
-0.019509334,
-0.004826913,
0.008564745,
0.027374916,
0.021647159,
-0.007892474,
-0.0007869784,
0.009842062,
0.00012573588,
0.007280706,
-0.015018557,
-0.038373288,
-0.009116009,
0.011401733,
0.0014857212,
0.04278339,
0.002794971,
0.0010621898,
0.00015924443,
0.0013361407,
-0.008537855,
-0.003919346,
0.033506036,
0.016927809,
0.01341855,
0.018124454,
0.01450763,
-0.0016848817,
0.0111933295,
0.004067246,
-0.00968744,
0.01191266,
0.011247111,
0.017936217,
0.0012067283,
0.008463904,
-0.037324544,
-0.016295874,
-0.021647159,
0.0002968501,
0.012477369,
0.016645456,
-0.0034958145,
0.0067731407,
0.026245499,
-0.02676987,
-0.0065647364,
-0.015206793,
0.0070790243,
0.007912641,
-0.0115361875,
-0.021364804,
-0.63204324,
-0.02812786,
0.043590117,
0.021001779,
-0.002484045,
0.038642194,
0.0075160014,
-0.004379852,
0.0154488105,
0.014373176,
-0.02288414,
0.011092489,
-0.008941218,
-0.0033344692,
-0.0172505,
-0.011253834,
-0.017142937,
-0.03573798,
0.026850544,
-0.012927791,
-0.0058958256,
0.0027327857,
-0.00588238,
0.0061277593,
0.025089191,
0.016753018,
0.021902623,
-0.012504259,
-0.011637028,
0.008275668,
-0.013317709,
0.02303204,
-0.02270935,
-0.010352989,
0.062333062,
-0.013089136,
-0.008578191,
0.014910993,
0.03417831,
0.04130439,
0.005721035,
0.007132806,
0.034904364,
0.00469582,
-0.014050486,
0.010151307,
0.03111275,
-0.014816876,
-0.002289086,
0.0073143197,
0.012806782,
0.019899251,
-0.025156418,
0.013169808,
0.0115092965,
0.024632046,
0.016470665,
-0.013075691,
0.021889176,
-0.0031848887,
-0.0047159884,
0.02335473,
0.0015789989,
-0.020584969,
-0.006359693,
0.00083445763,
-0.038050596,
0.00056386815,
0.004171448,
0.02214464,
0.0041680867,
0.02901526,
0.012437033,
0.013721072,
0.009156344,
0.012181569,
-0.0014563092,
0.009593322,
-0.027240463,
0.017976554,
-0.0070790243,
0.009116009,
-0.015637048,
0.023717757,
0.018729499,
0.018890843,
-0.045096006,
0.02149926,
0.028638788,
-0.016672347,
0.01804378,
-0.00063949876,
-0.02046396,
-0.03753967,
-0.024900956,
0.028289206,
-0.03148922,
0.022951366,
-0.0030537955,
-0.01648411,
-0.009835339,
-0.0071462514,
-0.01851437,
-0.0081546595,
0.039852284,
0.013808467,
-0.04149263,
0.00561011,
0.042299356,
-0.01910597,
0.007038688,
-0.020558078,
-0.0045882566,
-0.036894288,
0.01851437,
-0.021633713,
-0.010843747,
0.0049882582,
0.008504241,
-0.02014127,
0.009431977,
-0.022790022,
0.026500963,
-0.012107619,
-0.0042689275,
0.010897529,
-0.0011512658,
-0.017425291,
-0.01055467,
-0.0014546285,
-0.0016949659,
-0.022158086,
0.029149715,
-0.011448792,
0.010131139,
0.0012495856,
0.015489147,
0.010971479,
0.0032033762,
-0.026232054,
-0.012463924,
-0.020127824,
0.012779891,
0.004359684,
0.003593294,
-0.02523709,
-0.0030806866,
0.0107966885,
0.022023631,
0.014144603,
0.0037580007,
-0.020060597,
0.0006458013,
0.024753056,
0.008437014,
-0.010480721,
0.002783206,
-0.03415142,
-0.025142973,
-0.007845415,
0.005936162,
-0.0005453807,
-0.046010297,
0.009902567,
0.0051025446,
-0.020679086,
0.024551375,
0.014736203,
-0.016591674,
-0.01406393,
-0.0017067306,
-0.014628639,
-0.03417831,
0.005573135,
0.007952978,
0.012645436,
0.008000037,
0.006786586,
-0.0017361424,
-0.0061815414,
0.016268983,
-0.025680792,
-0.0047529633,
-0.0043496,
-0.0042722886,
0.005825237,
0.026541298,
0.027495926,
-0.00023655572,
0.042380027,
-0.038131267,
0.013156364,
-0.015206793,
0.0058084303,
0.0037277483,
-0.0068571744,
0.015489147,
0.0048033837,
-0.00294119,
0.020531187,
0.023744648,
-0.03447411,
-0.0006600871,
-0.037163198,
0.019885806,
-0.012295855,
0.0014731161,
-0.024013557,
0.019428661,
-0.0078050783,
0.0028756435,
0.030198459,
-0.004295818,
-0.022749685,
-0.01132106,
0.02246733,
0.005788262,
-0.025922809,
-0.023717757,
-0.020692533,
-0.018232018,
-0.007321042,
0.02291103,
0.0010168115,
-0.025183309,
0.013425272,
-0.0044941385,
0.042380027,
0.026218608,
-0.022373213,
-0.006144566,
0.010937866,
0.028316097,
0.019482443,
-0.019590007,
-0.010238702,
0.0107160155,
0.0058285985,
0.030601822,
0.005815153,
0.01786899,
-0.0057815393,
0.0065580136,
0.00865214,
-0.006544568,
-0.018527817,
0.010803412,
0.014158049,
-0.008537855,
-0.0013403423,
0.002400011,
0.021687495,
-0.0031748046,
0.00028886687,
-0.0021294216,
-0.023166494,
0.0049143084,
0.011166438,
0.05066242,
0.017116046,
0.013169808,
-0.0043361546,
0.018541262,
-0.008739537,
0.010272317,
-0.011300893,
0.02117657,
-0.01964379,
-0.008376509,
0.016080746,
-0.038615305,
-0.005025233,
-0.00043487595,
-0.0053882604,
-0.0048168288,
0.02004715,
0.026554745,
-0.009310967,
0.030790059,
-0.005280697,
-0.014736203,
-0.016470665,
0.02901526,
0.008719368,
-0.018326135,
-0.025277428,
-0.026662309,
0.0077445735,
-0.019563116,
0.016457219,
-0.0084975185,
0.015327802,
0.033398475,
0.008840377,
-0.007280706,
-0.00333615,
0.016201755,
-0.007791633,
0.0086992,
-0.010763075,
-0.007502556,
0.0088471,
-0.02090766,
-0.0034336294,
0.043859027,
0.010299208,
0.0006508434,
-0.010393325,
-0.017048819,
-0.037647232,
0.021149678,
-0.009277354,
0.012571487,
-0.0062790206,
0.0026184996,
-0.0068773427,
0.013028632,
0.017761426,
0.03974472,
0.019146306,
-0.0119866105,
-0.030924512,
0.008322728,
0.009358026,
0.020598415,
0.056309503,
0.03205393,
0.024927847,
-0.00013624012,
0.03181191,
-0.014090821,
-0.038050596,
0.01618831,
-0.0001673327,
-0.027966516,
-0.008194996,
0.01786899,
-0.005815153,
0.010137862,
0.024336247,
-0.0065647364,
-0.0342052,
0.025411882,
-0.0016428648,
0.01060173,
-0.015300911,
0.030440478,
0.026554745,
-0.0016453858,
0.0016621925,
0.02028917,
0.008934495,
0.020100933,
-0.0052134693,
-0.019979924,
0.015260574,
0.0032974943,
-0.0016638732,
-0.011852155,
-0.026137937,
0.010151307,
0.007663901,
0.016268983,
0.00397985,
0.003576487,
0.027885843,
0.013068968,
0.001287401,
-0.0016563102,
-0.018863954,
-0.01176476,
0.0046924585,
0.008087432,
-0.009579876,
0.016094193,
-0.015045447,
-0.020490851,
-0.015811838,
0.029069042,
-0.0028924504,
0.027966516,
-0.010884084,
0.012006778,
-0.029714422,
-0.017492518,
-0.019307652,
-0.015704274,
-0.019428661,
-0.016121082,
-0.014561412,
0.0025596756,
0.0047832155,
-0.009996685,
0.0092907995,
0.02167405,
-0.021795059,
-0.018595044,
0.005815153,
0.00008434913,
0.019791689,
0.0018100924,
-0.004480693,
0.011576524,
0.020423625,
0.0018302605,
-0.007085747,
0.0014126116,
-0.027751388,
0.0060605323,
0.0038521187,
-0.012316023,
-0.017680755,
-0.0030605183,
-0.002268918,
0.010682402,
-0.037109416,
0.018850507,
-0.0030974932,
0.0063529704,
-0.03632958,
0.010016853,
0.0079597,
-0.014480739,
-0.009364749,
0.000882357,
-0.021069005,
-0.010615175,
-0.023314394,
-0.010258871,
-0.004789938,
0.010352989,
-0.005163049,
-0.022695903,
-0.016941255,
0.00048151484,
-0.0027546345,
0.008826932,
-0.012961404,
0.032806873,
0.011905937,
-0.0011874004,
-0.0040168255,
0.0127530005,
-0.012000055,
-0.0012983254,
-0.006554652,
0.033936292,
0.010810134,
-0.006729443,
0.051764946,
0.021660604,
-0.013082413,
-0.027778279,
-0.009149622,
-0.01957656,
0.05434647,
0.028100971,
-0.02123035,
-0.0430523,
0.0045042224,
-0.018863954,
-0.008114323,
-0.001843706,
-0.015798392,
-0.012820227,
0.00568406,
0.00496809,
-0.00000986743,
0.032215275,
-0.032645527,
-0.001599167,
0.0036101008,
-0.0022403465,
-0.0055529666,
-0.010527779,
0.014117712,
-0.011031983,
-0.0033327886,
-0.03054804,
-0.03208082,
0.008591636,
0.0001982152,
0.00788575,
0.04122372,
0.021741277,
0.00007893944,
0.0045916177,
0.006591627,
-0.0021663965,
0.0032235442,
0.014534521,
0.008914327,
-0.023139603,
0.02043707,
0.01757319,
0.0011899215,
0.025922809,
-0.01846059,
0.020168161,
0.0138891395,
-0.008040373,
-0.013378213,
-0.007946256,
-0.019590007,
-0.015542929,
-0.005200024,
-0.0039025391,
-0.007159697,
-0.03794303,
-0.013700903,
-0.017411845,
-0.009734498,
-0.0031546364,
-0.0135462815,
0.019764798,
-0.010621898,
0.03425898,
-0.00030147197,
0.005852128,
0.022803467,
-0.020275723,
0.013640399,
0.018850507,
0.012988295,
-0.00040126237,
0.0046285926,
0.0041882545,
0.018595044,
-0.011495852,
0.013324431,
-0.016753018,
-0.03288755,
0.0030470728,
-0.031032076,
0.008147937,
-0.010070635,
-0.03326402,
-0.05743892,
-0.002194968,
0.0099496255,
-0.02120346,
0.027132899,
0.008067264,
-0.020410178,
0.010043744,
-0.008880713,
0.012026946,
-0.01663201,
0.011092489,
0.041385066,
-0.0037647232,
-0.015247129,
-0.014211831,
0.014144603,
0.0028773241,
0.029203497,
0.01851437,
-0.015556375,
-0.009606767,
-0.002463877,
-0.0045243907,
-0.023865657,
-0.044746425,
0.043213647,
0.030978294,
-0.0012823589,
0.008141214,
-0.01583873,
-0.0130958585,
0.007657178,
-0.027643826,
-0.0065479293,
-0.01583873,
0.006124398,
-0.03202704,
0.019025298,
-0.0023546328,
0.0066790227,
-0.018877398,
-0.022897584,
-0.00081723067,
-0.026756426,
0.025640454,
0.003939514,
-0.01169081,
-0.0004890779,
0.0030420308,
0.0073412103,
-0.0020000092,
-0.0007533648,
0.012927791,
-0.0092370175,
-0.019213535,
0.049640566,
-0.007025243,
-0.0116706425,
0.037835468,
0.005378176,
-0.011354675,
-0.01618831,
-0.0048874174,
-0.0250623,
-0.022951366,
-0.003052115,
0.028181642,
0.0064470884,
-0.020208497,
-0.0020756398,
-0.017895881,
0.00442355,
-0.021754723,
-0.014615194,
0.009189959,
-0.036141343,
-0.012289132,
-0.008396678,
0.005374815,
0.019590007,
0.00462187,
0.016282428,
0.002033623,
0.021297578,
-0.024390029,
0.0146555295,
-0.028262315,
0.0020252194,
-0.011152993,
-0.018769834,
-0.038991775,
-0.024524484,
0.00946559,
-0.013653845,
-0.033156455,
0.0073882695,
-0.033990074,
0.013116027,
0.012598378,
0.012766446,
0.0258018,
-0.01337149,
0.019630343,
-0.00561011,
0.013472331,
0.01846059,
-0.019038744,
0.011744592,
0.018097563,
-0.029284168,
-0.001875639,
0.00022332036,
-0.014050486,
0.0157715,
-0.029095933,
-0.014413512,
-0.010789966,
-0.00030357283,
-0.020652195,
-0.03138166,
-0.002016816,
-0.0021243796,
-0.028827025,
0.013761408,
0.013848804,
-0.021095896,
-0.006010112,
0.009714331,
-0.018823616,
0.000012893967,
-0.0032369897,
0.0007941213,
0.0016882431,
-0.006423559,
-0.0101109715,
0.0025294235,
-0.031327877,
0.04428928,
-0.0062588523,
-0.023287503,
-0.008161382,
0.015623602,
-0.018635381,
-0.004554643,
-0.014561412,
-0.0029142993,
-0.0016991675,
-0.0009075672,
-0.009068949,
-0.019522779,
-0.005583219,
0.005200024,
0.0018504288,
-0.023300948,
0.0166589,
-0.011079043,
0.03022535,
-0.018998407,
-0.029230388,
-0.018837063,
0.03659849,
-0.010910975,
0.002542869,
0.03081695,
-0.0075765057,
0.009257185,
-0.005593303,
0.0047764927,
0.00023760615,
0.0032874101,
0.025734574,
-0.03815816,
-0.0010840386,
0.008907604,
0.0040504388,
-0.007879028,
0.017761426,
0.014722757,
0.009714331,
-0.008168105,
0.0032588386,
-0.020369843,
0.007993314,
0.008201718,
0.03148922,
0.0013058884,
-0.025438773,
0.0003726908,
0.022534559,
-0.0013966451,
-0.033559818,
-0.004867249,
-0.0028016935,
-0.0017663947,
0.002926064,
0.010709293,
-0.017008482,
0.0034689235,
-0.0040201866,
-0.019415217,
-0.0023546328,
0.006198348,
0.006571459,
-0.014467293,
0.008114323,
-0.0017479073,
-0.015058893,
0.006591627,
-0.0030168206,
-0.012403418,
-0.012369805,
-0.010406771,
0.019468997,
-0.010595007,
-0.022050522,
0.010406771,
-0.003519344,
0.018716052,
0.0056134714,
-0.016645456,
-0.005563051,
0.0336136,
0.2087808,
-0.03054804,
0.013505945,
-0.009075672,
-0.0014277376,
0.0003023123,
-0.00924374,
-0.015758056,
-0.0032588386,
-0.003057157,
0.029875768,
0.00946559,
-0.02718668,
-0.007401715,
0.0027243823,
-0.024363138,
-0.0258018,
0.013902585,
-0.02701189,
0.003892455,
-0.0028453914,
-0.0172505,
0.02523709,
0.016537892,
0.035872433,
0.0055764965,
-0.01253115,
0.01062862,
0.038050596,
0.013727794,
-0.03482369,
0.023099266,
0.006013473,
0.007973146,
0.024632046,
0.0029495934,
-0.013754685,
-0.0017327811,
0.021216905,
0.012080728,
0.0060840617,
0.0022000102,
-0.023233721,
-0.0026184996,
-0.010595007,
-0.008410123,
-0.0033210237,
-0.017949663,
0.005062208,
0.021069005,
-0.044316173,
0.0057647326,
0.010689125,
0.014776539,
-0.018984962,
-0.015529484,
0.0015907637,
0.03294133,
0.0034487555,
0.004679013,
-0.022426995,
0.012638714,
-0.034662344,
0.020679086,
-0.02671609,
0.038104378,
0.0010067273,
-0.00531431,
0.015932847,
-0.0076504555,
-0.0029378287,
-0.0024437087,
-0.0023932883,
0.017963108,
-0.001678159,
-0.022494221,
0.016605118,
0.022628676,
0.018863954,
0.022776576,
-0.00121093,
-0.006124398,
-0.029203497,
0.012020224,
-0.021405142,
-0.0336136,
0.0241749,
0.010211812,
-0.004994981,
0.010292484,
-0.0010840386,
-0.026218608,
-0.020369843,
-0.017290836,
-0.0054218736,
-0.0053714532,
0.00065168366,
-0.004685736,
-0.00993618,
-0.016618565,
-0.009015168,
0.0666356,
0.021136232,
0.007596674,
-0.016927809,
-0.0047563245,
-0.004490777,
0.020880768,
0.0064269206,
-0.02120346,
0.0028756435,
-0.019684125,
0.0014529479,
-0.0119597195,
0.0063697775,
0.020840432,
0.032215275,
-0.003420184,
0.010352989,
-0.0032638807,
-0.010588285,
-0.012074006,
0.005173133,
0.004352961,
-0.008726091,
-0.018689161,
0.0022033716,
0.010319375,
0.0018268992,
-0.031220313,
0.0038050597,
-0.0017067306,
0.0015369819,
0.0023563134,
-0.0069109565,
0.0009571473,
0.010574839,
-0.020356396,
-0.003482369,
0.033774946,
-0.02075976,
-0.00092101266,
0.016753018,
0.019657234,
0.010507612,
-0.00001196828,
0.033075783,
0.018648826,
-0.021795059,
-0.0026722813,
-0.006359693,
-0.006880704,
-0.01583873,
-0.026016926,
0.012430309,
-0.021714386,
-0.004873972,
-0.012941237,
0.0011613499,
0.0069042337,
-0.042272463,
0.021512704,
0.013553004,
-0.022480777,
-0.009606767,
-0.0022252204,
-0.1701655,
0.0134924995,
0.01893118,
0.008141214,
0.02523709,
-0.0031243842,
-0.0012588294,
0.012860564,
-0.014426958,
-0.0012521066,
0.047516186,
-0.0031764852,
-0.0084437365,
-0.021055559,
0.0005449605,
0.0080739865,
-0.015368138,
0.03210771,
0.014964775,
0.0139160305,
0.03581865,
-0.0108773615,
0.0007995835,
0.0051697716,
-0.0051596877,
0.018541262,
0.004873972,
-0.010931143,
-0.002852114,
-0.014400067,
-0.00073067565,
0.01074963,
0.026756426,
-0.002542869,
0.008517686,
-0.0030470728,
-0.0005785741,
0.0063428865,
0.01122022,
0.027280798,
0.035899326,
0.034124527,
0.0040302705,
-0.007838692,
-0.008739537,
0.012396696,
-0.008907604,
0.02659508,
0.013364768,
-0.0016058898,
0.012779891,
0.0013084094,
-0.0023092544,
0.020033706,
0.031193422,
0.02335473,
-0.016174864,
0.012813505,
-0.0021092535,
0.0026201801,
-0.0022790022,
0.01037988,
0.037969925,
-0.005277335,
0.005021872,
-0.017519409,
0.011852155,
0.010373157,
-0.007879028,
0.0016991675,
-0.009512649,
-0.040793467,
0.012423587,
-0.023018593,
0.021512704,
0.008356341,
-0.007657178,
0.016430328,
0.011542911,
-0.01067568,
-0.02093455,
-0.006534484,
-0.010635343,
-0.00284203,
-0.014561412,
0.015260574,
0.0050151492,
0.012954682,
-0.01586562,
-0.018998407,
-0.0055159917,
-0.0353884,
0.006487425,
-0.018272353,
0.016779909,
0.03138166,
-0.021122787,
0.012470646,
-0.023005148,
-0.007495833,
0.033344693,
-0.002021858,
-0.020584969,
0.006998352,
0.015153011,
-0.0013638719,
0.003062199,
-0.011758038,
0.040524557,
-0.00035399324,
-0.02270935,
-0.009203404,
-0.00047017023,
0.012779891,
-0.017640417,
0.0026117768,
0.013707627,
-0.00032962338,
-0.00072773447,
-0.04579517,
0.07895163,
0.012584932,
0.008188273,
0.015300911,
-0.00013014766,
-0.023099266,
-0.12294511,
-0.027697608,
0.007159697,
0.02424213,
0.006292466,
-0.00079328095,
-0.00035462348,
0.014010149,
-0.016430328,
0.02503541,
-0.026084155,
-0.027697608,
-0.0047294335,
-0.013707627,
0.019711016,
-0.010272317,
0.0037949756,
-0.01329754,
-0.029875768,
0.042890955,
-0.018796725,
-0.0068101157,
0.023919439,
-0.0016378227,
-0.015556375,
0.0013411826,
-0.012047115,
0.010991648,
0.005152965,
0.0104269385,
0.022521112,
0.010561394,
0.018151345,
-0.0031193423,
-0.021015223,
-0.03111275,
-0.0022924475,
-0.015959738,
0.03113964,
-0.01527402,
-0.002479003,
-0.0079597,
0.00085840735,
-0.0100034075,
-0.009741222,
0.00006244777,
-0.023045484,
0.012040392,
0.028558115,
-0.022211866,
-0.04369768,
-0.028020298,
-0.034393437,
-0.013956367,
0.01757319,
-0.030010223,
-0.02807408,
0.019347988,
-0.028827025,
0.00026869873,
-0.020006815,
0.013472331,
-0.015852174,
0.0184337,
0.012625269,
-0.0157715,
-0.010547948,
-0.03667916,
0.019388326,
0.014857211,
0.0063428865,
-0.015354693,
-0.01737151,
0.012255519,
-0.007811801,
0.0038622026,
-0.008342896,
-0.020329505,
0.0035159825,
-0.03536151,
-0.0074823876,
-0.0025832052,
0.025021965,
-0.01583873,
0.011892492,
0.015153011,
0.02990266,
0.005509269,
-0.0016033688,
0.009149622,
-0.03084384,
0.03815816,
0.014991666,
-0.018393362,
-0.013364768,
0.0009941222,
-0.007213479,
-0.012275687,
-0.0005995826,
0.017169828,
-0.004867249,
-0.004937838,
-0.05466916,
0.028342988,
-0.012510982,
0.0048470814,
0.0034050578,
-0.010857193,
-0.016389992,
0.0062689367,
0.0056739757,
0.011919383,
-0.028988369,
0.0017395038,
-0.0010655512,
-0.002080682,
-0.028638788,
-0.009270631,
0.04205734,
-0.013008463,
0.0043159863,
0.016591674,
-0.016766464,
0.029311059,
0.007838692,
0.024484146,
0.0021042114,
-0.035415288,
-0.030682495,
0.0032907715,
0.0021176569,
-0.0013428633,
0.0007327765,
-0.0412775,
-0.017559744,
0.0025697597,
0.020100933,
-0.0168068,
-0.008786595,
0.038104378,
0.0070991926,
0.013734518,
-0.0042622047,
-0.033210237,
-0.0052975034,
-0.022211866,
-0.007300874,
-0.006480702,
-0.030440478,
0.008020205,
-0.011704256,
-0.016242092,
0.022211866,
0.0061546504,
0.0018033697,
-0.0086992,
-0.0176942,
-0.0026353062,
-0.005146242,
-0.020195052,
-0.01583873,
-0.02812786,
0.012416864,
0.012934513,
-0.0074823876,
-0.00400338,
0.006581543,
0.0036907734,
-0.014897548,
0.020988332,
0.010218535,
-0.017344618,
-0.005394983,
0.0073681013,
0.0009386598,
0.0026168188,
0.014332839,
0.0011974846,
-0.019011853,
-0.007905919,
-0.019092524,
0.014144603,
0.028665679,
0.021485813,
-0.024027001,
0.014763094,
0.020800097,
-0.03474302,
0.011179884,
0.0071933107,
0.0069109565,
0.0168068,
-0.005505908,
0.025250537,
0.0146824205,
0.025748018,
0.007495833,
0.01981858,
0.022830358,
-0.009089118,
0.0018403446,
0.011267279,
0.0017294198,
-0.0051933015,
-0.0010176518,
-0.029660642,
-0.0010336182,
0.008994999,
-0.037378322,
-0.046521224,
-0.017021928,
0.007408438,
-0.008013482,
0.00953954,
-0.0020874047,
0.0010638705,
0.0057748165,
0.01690092,
0.016363101,
-0.016820246,
-0.013337877,
0.02869257,
0.021405142,
0.006991629,
-0.010978202,
-0.009142899,
0.0081008775,
0.01495133,
0.016121082,
-0.022964813,
0.019200088,
-0.0010907614,
0.006991629,
-0.033210237,
-0.0400943,
0.0013336196,
0.006534484,
0.006295827,
0.0057680937,
0.028450552,
-0.009579876,
0.09072983,
0.007126083,
-0.027348025,
-0.006702552,
-0.005183217,
0.02256145,
-0.0052638897,
0.00788575,
0.0021697578,
-0.041385066,
-0.0064000296,
0.00630255,
-0.0036369916,
-0.027966516,
-0.01512612,
-0.0074554966,
0.017479073,
0.0038386732,
-0.009129454,
-0.00078655826,
0.029418623,
-0.0038991778,
0.004584895,
0.019805133,
-0.028638788,
0.0028134584,
0.033344693,
0.015986629,
0.0044672475,
-0.04063212,
0.0031176615,
0.009425254,
-0.019858915,
-0.017210163,
0.025842136,
-0.034097638,
-0.00031596786,
-0.017062264,
-0.00533784,
0.00454792,
-0.0061916253,
0.020221943,
-0.022682458,
-0.020329505,
-0.005183217,
-0.014467293,
-0.020840432,
0.0036638824,
-0.023932884
] |
Notch receptors expressed on hematopoietic stem cells interact with their ligands on bone marrow stromal cells and thereby control cell fate decisions and survival. We recently demonstrated that Notch signaling is involved in proliferation and survival of B cell-derived tumor cells of classic Hodgkin disease and described a novel mechanism for the oncogenic capacity of Notch. In this study we investigated whether Notch signaling is involved in the tight interactions between neoplastic plasma cells and their bone marrow microenvironment, which are essential for tumor cell growth in multiple myeloma (MM). Here we demonstrate that Notch receptors and their ligand Jagged1 are | [
-0.03511177,
-0.019541845,
0.008870621,
-0.017608844,
-0.0119025195,
0.020084674,
-0.01235929,
0.013524387,
-0.030795617,
-0.0042036152,
0.020759901,
-0.012538027,
0.010002618,
0.0027009055,
-0.024003634,
-0.003164296,
0.026294108,
0.0023682571,
-0.004700105,
-0.0012991488,
-0.022507545,
0.036912374,
-0.00089368195,
-0.014179753,
-0.003415851,
0.007818062,
0.014047356,
-0.030345468,
0.0028548173,
0.0034886696,
0.005540828,
0.021474846,
-0.0055242786,
0.0016044901,
-0.002267304,
-0.00041125919,
0.00742749,
-0.012008438,
0.004064598,
0.011114756,
0.015172734,
0.012974937,
-0.0038858615,
-0.012326191,
-0.003604517,
0.011717163,
0.0071163564,
-0.002565198,
-0.03018659,
0.016112754,
0.027406247,
-0.0017046155,
-0.019051975,
0.0061333063,
-0.02177936,
-0.018403228,
0.017608844,
0.033946674,
0.0015027097,
-0.035217687,
0.0075400276,
-0.014669623,
-0.011008837,
0.011015457,
-0.010115156,
0.026783979,
-0.0021994505,
0.010439529,
0.0012337776,
-0.0038825516,
0.025486486,
0.010552067,
-0.008155676,
0.012319571,
-0.00052255567,
-0.017741242,
-0.016271632,
-0.012015058,
-0.01685418,
0.013663404,
0.02620143,
-0.014788781,
-0.012471828,
0.04813967,
0.01783392,
-0.005143636,
0.008751463,
0.016311351,
0.009638526,
-0.00075135485,
0.004895391,
0.009651765,
0.009108936,
0.012710143,
-0.022639943,
0.017066015,
0.022970935,
0.025023095,
-0.00012494998,
-0.025407046,
-0.018773941,
0.010810242,
-0.0034655,
-0.007983559,
-0.0095590865,
0.0011717164,
-0.011703923,
-0.0037170548,
0.016033316,
0.013127195,
-0.03370836,
0.029127412,
-0.028306548,
-0.05107889,
0.041705158,
-0.008294692,
0.0013264557,
0.006010839,
-0.014298911,
0.009148655,
0.021368928,
0.024202231,
0.021527804,
-0.026386786,
0.016258392,
0.033496525,
0.0035250788,
0.011227293,
-0.010055576,
0.0074341097,
0.005878441,
0.014762302,
-0.014020877,
-0.0050873673,
0.0010691084,
-0.0037369146,
-0.0047960933,
-0.009241333,
-0.011419269,
-0.018231113,
-0.005547448,
0.03807747,
0.0077518634,
-0.01884014,
0.01384876,
0.015980357,
0.037230127,
0.0013562451,
0.006964099,
0.000045020264,
-0.013272832,
-0.012279852,
0.023699122,
-0.029127412,
-0.009658385,
0.0014282361,
0.0043327026,
0.04710697,
-0.008314552,
-0.0063616913,
0.017423488,
-0.009962899,
0.022639943,
0.0074010105,
0.030822098,
0.024798019,
-0.00081631227,
0.003323173,
-0.001980995,
0.0005126259,
0.00043484246,
0.022150073,
-0.01187604,
-0.00038664156,
-0.030504344,
-0.012154074,
-0.0029077763,
0.01637755,
-0.042287707,
-0.028650781,
-0.009049357,
0.022057394,
0.011816462,
0.01534485,
-0.022361908,
0.0029309457,
0.023156293,
-0.031272247,
-0.01885338,
-0.0128624,
0.009737823,
0.014974138,
-0.0016665513,
-0.013074236,
-0.62067866,
-0.000010375865,
0.025076054,
-0.015225693,
0.009294292,
0.03505881,
-0.002525479,
-0.0060141487,
-0.02671778,
0.0138355205,
-0.019210853,
0.018628303,
0.003866002,
-0.024136033,
-0.020190593,
-0.035032332,
-0.0327551,
-0.016456988,
0.012339431,
0.0006139926,
-0.0121077355,
-0.010512347,
-0.008367511,
0.019171134,
-0.019621283,
0.013756082,
0.034529224,
-0.0153978085,
-0.009545847,
0.032913975,
-0.0018337029,
0.0064510596,
0.0014787127,
-0.008943439,
0.037759718,
0.006643036,
0.019700723,
0.02620143,
0.0039553703,
0.027459206,
-0.005345542,
0.0057129445,
0.027459206,
-0.010353471,
-0.016999817,
0.0016078,
0.0042400244,
0.012332811,
-0.016629104,
-0.008678645,
0.021064414,
0.0035283887,
-0.038818896,
-0.009148655,
0.005411741,
-0.012604225,
0.031616483,
-0.022057394,
0.0109558785,
0.0024410756,
-0.003220565,
0.016152473,
-0.03609151,
-0.010757282,
0.0023517075,
0.018628303,
-0.024877457,
-0.003122922,
0.016006837,
0.002528789,
0.023606444,
0.023474045,
-0.0026347067,
0.017277852,
0.010836721,
0.013233113,
-0.008096096,
0.014471028,
-0.00024017702,
0.005762594,
-0.01831055,
-0.01588768,
-0.03116633,
0.011180954,
0.010936019,
0.0042003053,
-0.006983959,
0.031219289,
0.0266913,
0.009049357,
-0.003124577,
0.003621067,
-0.006222674,
-0.043770555,
-0.01335227,
0.007182555,
0.013385369,
0.012544647,
0.009320771,
-0.052296944,
-0.0069442396,
-0.019091694,
0.00089450943,
-0.0019958897,
-0.0034985994,
0.012590986,
-0.03858058,
-0.021037934,
0.026876656,
-0.038236346,
0.017489687,
0.013742843,
-0.016814461,
-0.0051502557,
0.0034655,
-0.013021277,
0.023884477,
0.042181786,
-0.010538827,
0.0004609082,
0.016536426,
0.0022242751,
0.008029898,
-0.003617757,
0.015516967,
0.011525188,
0.007242134,
0.0018866619,
0.008168915,
-0.033046372,
-0.009055977,
-0.015980357,
0.016986577,
-0.027406247,
0.038342267,
-0.007076637,
0.0022424797,
0.0025023094,
0.021898517,
-0.031854797,
-0.033496525,
0.009612046,
0.010949259,
-0.017224893,
-0.00891034,
-0.009003018,
-0.018548865,
-0.006149856,
0.015225693,
-0.013636924,
0.0056401263,
-0.016218672,
-0.027459206,
-0.0006777088,
0.010525587,
0.0025569233,
-0.024890697,
-0.0043889713,
0.007063397,
-0.03474106,
-0.008043137,
0.02870374,
-0.021660203,
0.004637216,
-0.004918561,
-0.02228247,
-0.0008283108,
0.012981558,
0.022441346,
-0.021964716,
0.017066015,
-0.015980357,
-0.02471858,
0.009340632,
0.00014263744,
0.0067026145,
-0.002570163,
-0.003710435,
-0.0063583814,
-0.0029474956,
-0.008791182,
-0.03370836,
0.013650164,
-0.017675042,
0.029842358,
0.023699122,
0.031298727,
0.016430508,
-0.0027538643,
0.02822711,
-0.021435127,
0.027432727,
-0.03315229,
0.034370344,
-0.0035019093,
-0.052932452,
0.015927399,
0.015675843,
-0.0025949876,
0.02820063,
-0.021435127,
-0.0128624,
0.018257592,
-0.0046603857,
0.009254573,
-0.004806023,
-0.0058122426,
-0.026174951,
0.0042698137,
0.0034820496,
0.008791182,
0.014802021,
-0.0069045206,
-0.0070104385,
0.009234713,
0.0015176043,
-0.008698504,
0.003660786,
-0.0028366128,
-0.025023095,
-0.0049318005,
0.0097643025,
0.011538427,
-0.01783392,
0.006884661,
0.010002618,
0.01880042,
0.031298727,
0.016986577,
-0.0077982023,
-0.023421086,
0.01237253,
0.011452368,
-0.01435187,
-0.0097245835,
-0.004501509,
0.022957696,
-0.0041672057,
0.03407907,
-0.010671224,
-0.00095326075,
0.0036276868,
-0.008976539,
0.030954495,
-0.0018337029,
-0.029445166,
0.016761502,
-0.0027604843,
-0.011346451,
-0.009870221,
-0.010969118,
0.016576145,
-0.017489687,
0.0053687114,
0.01984636,
-0.011154475,
0.0057526636,
0.00088375213,
0.029868837,
0.009247953,
0.013332411,
-0.011598006,
0.018244352,
-0.026042555,
0.010002618,
0.009883461,
-0.015675843,
-0.012399009,
-0.0065139486,
0.010982358,
-0.01885338,
-0.018668022,
0.01984636,
-0.04167868,
-0.008566107,
0.01738377,
0.016721781,
0.014735823,
0.0121077355,
0.0115318075,
0.02277234,
-0.035005853,
0.034237947,
0.022454586,
-0.02274586,
0.005835412,
-0.03063674,
-0.027075253,
-0.002914396,
0.008744843,
0.030980974,
0.010499108,
-0.0044485503,
-0.005540828,
0.0015151219,
-0.021713162,
-0.0016317971,
-0.002674426,
0.008248353,
0.0074010105,
0.008334411,
0.00594464,
-0.021382168,
-0.001265222,
0.022070635,
0.009605426,
0.0026264319,
-0.027909357,
-0.035773758,
-0.021196812,
0.0037799436,
-0.014537226,
-0.0013934819,
-0.016311351,
0.014232713,
0.006576837,
0.026492706,
0.018906338,
0.013444948,
-0.0012974938,
-0.028094713,
-0.031219289,
-0.01880042,
-0.030610261,
0.027459206,
0.019515365,
0.0042698137,
0.014457788,
-0.013319171,
-0.009797402,
-0.014404829,
0.004898701,
0.0154375285,
-0.021580763,
0.02670454,
0.03151056,
-0.0055342084,
0.00842047,
-0.008539627,
0.021646963,
0.009036117,
-0.008168915,
0.006891281,
-0.0036938854,
0.008559487,
0.005891681,
0.022639943,
0.024096314,
0.02176612,
0.00079438393,
-0.015503727,
0.011022077,
0.002336813,
-0.005487869,
0.0044485503,
0.010439529,
-0.001832048,
0.005103917,
-0.008883861,
-0.028306548,
-0.0086521655,
0.022917977,
-0.0029872146,
-0.0052594836,
0.018164912,
0.002815098,
-0.0045213685,
-0.0056401263,
-0.01835027,
0.004064598,
0.034026112,
0.009194994,
-0.005540828,
-0.020667223,
0.027485685,
-0.025407046,
-0.0017377149,
0.011055177,
-0.021011455,
0.0168277,
-0.0024112863,
0.004852362,
0.006676135,
-0.007970319,
-0.019051975,
-0.017569125,
0.019488886,
-0.0018039136,
-0.002174626,
-0.011220673,
-0.028121192,
-0.033046372,
-0.024162512,
-0.0021862108,
0.0132993115,
0.0006636416,
-0.04392943,
0.0016549666,
0.031245768,
0.020984976,
0.011856181,
0.017198412,
-0.013597205,
0.026016075,
0.006249154,
-0.027273849,
0.0074672094,
-0.031484082,
0.010201214,
0.009201614,
0.0063451417,
-0.025777759,
-0.00890372,
0.009843742,
0.008466809,
-0.019422688,
-0.00047456168,
-0.029630521,
-0.008811042,
-0.0018734222,
0.005196595,
0.007732004,
-0.0033810968,
0.01783392,
-0.021011455,
-0.008149056,
-0.025976356,
-0.0058618914,
-0.00843371,
-0.026082274,
-0.0071097366,
0.032861017,
-0.028544864,
0.0059214705,
0.028333027,
-0.010744043,
0.006970719,
-0.004322773,
-0.0073348116,
0.03466162,
0.0015738732,
0.013034517,
0.016165713,
-0.014404829,
-0.0007484586,
-0.014788781,
0.026651582,
-0.0057791434,
-0.03180184,
-0.014656384,
0.004312843,
-0.019872839,
-0.027035534,
-0.018442947,
-0.023540245,
0.013471428,
-0.017251372,
-0.014179753,
-0.028465426,
-0.008486669,
0.0017575745,
0.0105057275,
-0.0035250788,
-0.020561304,
-0.020508345,
0.022547264,
0.0073679113,
-0.0095193675,
0.021421887,
-0.036303345,
-0.007480449,
0.02820063,
0.009479648,
-0.025407046,
-0.015133014,
0.014921179,
-0.0059115407,
-0.016735023,
-0.027035534,
-0.051555518,
0.005345542,
-0.010029097,
0.037918594,
0.039825115,
0.037309565,
0.013491288,
0.020018475,
0.00084361923,
-0.007990179,
0.006643036,
-0.014179753,
0.0132993115,
-0.007632706,
0.015212453,
-0.015133014,
-0.009036117,
0.046630338,
-0.0012445349,
0.027856397,
0.02132921,
0.010631505,
-0.0049284906,
0.009473029,
-0.039242566,
-0.036859415,
0.0327551,
-0.0053687114,
0.0071626953,
-0.021435127,
-0.00890372,
0.021541044,
0.0021001527,
-0.004749754,
-0.015980357,
-0.005057578,
-0.02520845,
0.017794201,
-0.01934325,
0.00020294028,
-0.0058850613,
-0.0025850579,
-0.006739024,
-0.012220273,
0.012405629,
0.009168515,
0.0020025095,
0.011836321,
-0.027326807,
0.018244352,
0.0033479973,
-0.029868837,
-0.014153274,
-0.004994689,
-0.0065569775,
-0.030716179,
-0.014484268,
-0.027856397,
-0.008294692,
0.009651765,
0.010062196,
-0.017171932,
-0.00544815,
-0.008486669,
0.0032106352,
0.043399844,
-0.029021494,
0.019912558,
-0.0266913,
0.016523186,
0.0038494521,
0.0021481465,
-0.036276866,
-0.0042334045,
-0.018270832,
0.0028084782,
0.03704477,
0.027062014,
-0.015225693,
-0.019131413,
-0.0022143454,
0.015569925,
-0.0111610945,
-0.017516166,
0.005540828,
-0.015066816,
-0.013623685,
-0.0128491605,
-0.015556686,
-0.035005853,
0.008129196,
0.014192994,
-0.010452769,
0.004819263,
-0.006785363,
-0.021249771,
0.028041754,
-0.007526788,
0.021037934,
0.021885278,
-0.022481065,
-0.022534024,
-0.022388387,
-0.009856981,
-0.016946858,
-0.024996616,
0.03667406,
-0.03211959,
0.015569925,
0.027962316,
0.0029276358,
0.006878041,
-0.012154074,
0.0020074744,
0.044723816,
0.016218672,
-0.015556686,
0.013193393,
0.0023517075,
0.00033078645,
-0.024480265,
-0.008731604,
-0.010797002,
-0.029471645,
0.00017584019,
0.036753498,
0.023500524,
0.0030567232,
0.01686742,
-0.028597822,
-0.010538827,
-0.038183387,
-0.017410249,
-0.015980357,
-0.036912374,
-0.028147671,
-0.0069773393,
0.016218672,
0.004160586,
0.004786163,
-0.0052925833,
0.013332411,
0.02526141,
-0.025129013,
0.016483467,
0.014987377,
0.03760084,
-0.014100315,
-0.0040215687,
0.0042433343,
-0.024308149,
-0.0015730457,
-0.013782562,
-0.021845559,
-0.017714763,
-0.001434856,
0.027167931,
0.011750262,
-0.023500524,
0.015927399,
0.005133706,
0.03315229,
-0.0007472174,
-0.014126794,
0.023487285,
-0.0008705124,
-0.0062094345,
-0.0015283616,
-0.0012900465,
-0.004299603,
-0.0097643025,
0.0043360125,
0.010677844,
-0.006335212,
-0.017542645,
-0.006636416,
-0.011002217,
-0.008453569,
-0.0034985994,
-0.030107152,
-0.011743642,
-0.018946057,
0.007851161,
0.0062094345,
-0.012723383,
-0.005583857,
0.0111610945,
0.008950059,
-0.007314952,
-0.0077187642,
-0.007957079,
0.010101916,
-0.026678061,
-0.035879675,
-0.0020058195,
-0.022573745,
0.030954495,
0.013431708,
0.008499908,
-0.030610261,
0.002813443,
-0.042393625,
-0.028809657,
-0.0011154475,
0.0041672057,
0.006990579,
0.015728801,
-0.00071287685,
0.010459389,
0.000042511954,
0.017277852,
0.0084469495,
-0.029868837,
0.0044485503,
-0.012928599,
0.020190593,
0.0015275341,
-0.020574544,
-0.013928198,
0.03116633,
-0.012597606,
-0.004210235,
0.020137634,
-0.030716179,
0.010009238,
-0.010651365,
0.0016764811,
0.008387371,
0.019978756,
0.01731757,
-0.015133014,
-0.003412541,
0.01088306,
0.0036971953,
-0.017132213,
0.013636924,
0.011505327,
0.017410249,
0.010545447,
-0.009949659,
-0.029762918,
0.010254173,
-0.00093422865,
0.010015857,
0.019171134,
-0.008360891,
0.03807747,
0.01139941,
0.009605426,
0.008499908,
0.0052727233,
-0.013636924,
-0.0025221691,
-0.006050558,
0.0023848068,
-0.012399009,
0.005335612,
0.0008953369,
-0.025142252,
0.0029640452,
0.0032817987,
-0.0074076303,
-0.04199643,
0.015265412,
-0.007910741,
-0.007990179,
0.0042367144,
-0.0023914266,
-0.008195395,
-0.023672642,
-0.012173934,
-0.004362492,
-0.009075836,
-0.008526388,
-0.015728801,
0.021130614,
0.009638526,
0.011167714,
-0.0118628,
0.017728003,
0.0050079287,
0.19499478,
-0.028094713,
-0.006964099,
-0.0045246785,
0.0076856646,
-0.020746661,
0.0062756334,
-0.0030120392,
0.00893682,
0.0095590865,
0.023368128,
0.029842358,
0.0012188829,
0.0010840031,
0.032437343,
-0.009552467,
-0.010446149,
-0.021024695,
-0.014060596,
-0.020892298,
-0.0054746293,
-0.0034721198,
0.02128949,
-0.007619466,
0.039322007,
0.005027788,
-0.030954495,
0.025142252,
0.02817415,
0.0059148506,
-0.031484082,
0.034370344,
-0.013385369,
-0.014563706,
0.019277051,
-0.004153966,
-0.012835921,
-0.00037940108,
-0.0025337539,
0.0037865634,
0.0028448876,
-0.022957696,
-0.006970719,
0.009062597,
0.0051701157,
0.0012445349,
0.010922779,
-0.005027788,
-0.0012445349,
0.0065635974,
-0.027048774,
0.0023434327,
0.018111954,
0.026042555,
0.0042334045,
-0.0018370129,
0.0035747278,
-0.01186942,
-0.007235514,
0.016562905,
-0.00940683,
0.002182901,
-0.0081225755,
0.010717563,
-0.014219473,
0.032887496,
-0.019263811,
-0.001880042,
0.0025205142,
-0.0065172585,
0.0061068265,
0.006997199,
-0.0009267813,
-0.017185172,
-0.0013951368,
-0.020137634,
0.02817415,
0.010108536,
0.024678862,
0.018906338,
0.019727202,
0.011147855,
-0.02426843,
-0.0011775087,
0.00094664085,
-0.017516166,
0.0060604876,
-0.0041638957,
-0.012339431,
-0.0055739274,
0.020667223,
0.0028399227,
-0.011942239,
-0.019422688,
-0.011578146,
-0.0031742258,
0.008764703,
0.022163313,
-0.011650965,
-0.008049757,
-0.023871237,
0.0714416,
0.00890372,
0.016231911,
-0.030848578,
0.013557486,
0.0008444467,
0.016629104,
-0.004296293,
0.009353871,
0.02033623,
-0.020428907,
-0.010843341,
-0.014047356,
-0.009499508,
0.023527006,
0.0073679113,
-0.0146166645,
0.039745677,
-0.013756082,
0.0053687114,
-0.031298727,
0.0023980467,
0.054918412,
-0.012908739,
0.0097245835,
-0.0068383217,
-0.00019042459,
-0.016536426,
-0.0083277915,
-0.005799003,
-0.0074672094,
-0.007904121,
0.002038919,
0.027353287,
-0.01041967,
0.007275233,
-0.029233329,
-0.016099514,
0.00090774917,
0.0044121407,
-0.0036872656,
0.015781762,
0.0148285,
0.0032536644,
-0.025949875,
0.018244352,
-0.0060671074,
-0.022481065,
-0.019634522,
-0.009466409,
-0.0054316004,
-0.02128949,
0.0020505036,
0.01139941,
-0.016999817,
-0.01881366,
-0.02083934,
0.019859599,
0.0044386205,
-0.023182772,
0.024665622,
0.010187974,
-0.03217255,
-0.0040877676,
-0.00035995521,
-0.16480818,
0.030107152,
0.0071626953,
-0.008698504,
0.04067246,
0.016589385,
-0.020574544,
-0.010115156,
-0.017013056,
0.021223292,
0.03016011,
0.012968318,
-0.023566725,
-0.020998215,
0.0065205684,
0.012180554,
0.004018259,
0.037521403,
-0.007526788,
0.016629104,
0.025830718,
-0.0150270965,
0.024069835,
-0.024798019,
-0.008076237,
-0.01884014,
0.00991656,
-0.008129196,
0.0054680095,
0.0013967918,
-0.00056806725,
-0.007804822,
0.012802822,
0.010532207,
0.016920378,
0.012703523,
0.0033331027,
-0.012604225,
0.0063186623,
0.027512165,
0.032066632,
0.020548064,
-0.010763902,
0.015728801,
-0.014643144,
0.05438882,
0.009731203,
0.00013808627,
0.034211468,
-0.013994398,
0.029498124,
-0.016655583,
-0.015530206,
0.031828318,
0.016946858,
0.019674243,
0.0066926847,
0.017013056,
0.004402211,
-0.0035515584,
0.0026893206,
-0.010307131,
-0.00095326075,
0.0052694133,
0.009274432,
-0.018893098,
-0.010730803,
0.018734222,
-0.033602443,
0.008718364,
-0.011485468,
-0.0048325025,
0.023434326,
-0.005550758,
0.019568324,
0.024890697,
0.01731757,
-0.0032536644,
-0.010737423,
0.003766704,
0.00594133,
0.017754482,
-0.0267575,
-0.03312581,
-0.006034008,
-0.014073836,
0.010942639,
0.024334628,
0.029948276,
-0.0024510054,
0.012657184,
-0.02028327,
0.0208261,
-0.018178152,
0.0075532673,
0.01435187,
-0.010346851,
-0.02177936,
-0.011458988,
-0.0050377185,
0.026333828,
-0.017423488,
-0.0022987486,
-0.010942639,
0.018562105,
-0.008274833,
0.0014398209,
0.009201614,
0.035032332,
-0.02526141,
0.005199905,
-0.005246244,
0.029365728,
-0.005835412,
0.0055639977,
0.030477865,
0.00941345,
0.002285509,
-0.013239733,
-0.017171932,
0.084999084,
0.021514565,
-0.016642343,
0.01632459,
-0.014073836,
-0.023037134,
-0.13748138,
-0.013034517,
0.0059280903,
0.032966934,
-0.00495166,
0.012200413,
0.0032354596,
0.010578547,
-0.02083934,
0.015556686,
-0.03667406,
-0.0048722215,
-0.02077314,
-0.01636431,
-0.0051138466,
-0.004898701,
0.026942857,
-0.008672025,
-0.014272432,
0.029365728,
-0.010777142,
-0.03180184,
-0.03312581,
-0.018509146,
0.0058089327,
0.005828792,
-0.021686682,
0.0064510596,
-0.0013322481,
0.01738377,
0.01137955,
0.0025486485,
0.020932017,
-0.0033893716,
-0.032384384,
0.0031560212,
-0.0032619392,
-0.009009638,
0.038474664,
-0.019038735,
0.0074605895,
0.03701829,
-0.0036111372,
-0.0029309457,
-0.0031014073,
-0.009340632,
-0.028491905,
0.011035318,
0.020203833,
-0.007904121,
-0.02769752,
-0.036806457,
-0.023924196,
-0.009817261,
0.027353287,
0.004670316,
-0.010571927,
0.03805099,
-0.017582364,
-0.0015159494,
-0.0064179604,
0.0072222743,
-0.0045875674,
-0.0041407263,
0.037336044,
-0.0068449415,
-0.026452987,
-0.03511177,
0.028094713,
-0.017622083,
-0.011022077,
-0.0072024143,
-0.015675843,
0.021594005,
-0.011432509,
0.007765103,
-0.009049357,
-0.021223292,
-0.005239624,
-0.031007454,
-0.011604626,
-0.013928198,
0.014934419,
0.008804422,
0.033549484,
-0.010671224,
-0.008877241,
0.012279852,
0.005554068,
0.0032900735,
0.002371567,
0.030318988,
0.006878041,
-0.0072553735,
-0.02033623,
0.007559887,
0.00644113,
-0.0050145485,
0.0022755791,
0.03799803,
-0.00081631227,
-0.012590986,
-0.04599483,
0.02724737,
-0.025923396,
0.0033281378,
0.026982576,
-0.03773324,
0.0012867365,
-0.044300146,
0.020071434,
0.014034117,
-0.0013909994,
0.018535625,
0.007235514,
0.008711744,
-0.02424195,
-0.013272832,
0.039322007,
-0.0075069284,
0.0012056432,
0.041890513,
0.010790382,
-0.039322007,
0.029551083,
0.0041738255,
0.009208234,
0.0040877676,
-0.01336551,
0.03270214,
-0.005196595,
0.005626886,
-0.0043260828,
-0.055871673,
0.000113468646,
-0.00043897989,
-0.019409448,
-0.02820063,
-0.016721781,
0.0306897,
0.030504344,
0.02077314,
-0.009605426,
-0.03376132,
0.0029557704,
0.01186942,
-0.009545847,
-0.0055209687,
-0.024824498,
-0.010042337,
0.0012147455,
-0.017158693,
0.04157276,
0.0052627935,
0.005689775,
-0.043426324,
-0.020892298,
0.0040215687,
-0.005557378,
0.0023053684,
-0.032066632,
-0.0336554,
0.008685265,
0.029074453,
0.009042737,
0.0014729203,
0.0063484516,
-0.015265412,
-0.0118628,
0.01637755,
0.0010964153,
0.0056732255,
-0.035429526,
-0.009247953,
0.007030298,
-0.00042491267,
0.008579346,
0.004144036,
-0.01587444,
-0.020137634,
-0.026770739,
0.015212453,
0.012657184,
0.0026082273,
-0.012968318,
0.006931,
0.047848392,
0.014510747,
-0.029551083,
0.023924196,
0.01186942,
-0.014537226,
-0.012604225,
0.014418068,
0.028333027,
0.016986577,
0.0050741276,
0.028650781,
-0.021421887,
0.0386865,
-0.004673626,
0.03320525,
0.0009110591,
-0.015503727,
-0.0034754297,
-0.017052775,
-0.0050873673,
0.026400026,
-0.039454404,
-0.055342082,
-0.015993597,
0.0061697154,
0.024162512,
0.008142436,
0.008367511,
-0.002326883,
-0.0022457896,
0.00943331,
0.006295493,
-0.01633783,
-0.00741425,
0.04705401,
0.016165713,
-0.0030153492,
0.0012991488,
0.00042056837,
0.012154074,
-0.012723383,
0.011002217,
-0.011710543,
0.017661802,
-0.020164113,
0.016258392,
0.013756082,
-0.03317877,
-0.00989008,
-0.008877241,
-0.027935836,
0.006192885,
0.024096314,
-0.0406195,
0.0960675,
-0.0002623122,
-0.0060637975,
-0.016814461,
-0.03471458,
0.03670054,
0.018231113,
0.012981558,
-0.008791182,
-0.05012563,
0.033628922,
-0.0033314477,
0.022679662,
-0.049701955,
-0.014126794,
0.0208261,
-0.014471028,
-0.01235929,
0.017794201,
0.0037766336,
-0.008791182,
-0.009704724,
-0.013497908,
0.021501325,
-0.032887496,
0.0027340048,
0.00087961473,
-0.012776342,
-0.005894991,
-0.012332811,
0.005057578,
-0.0021382167,
-0.037812676,
-0.004071218,
0.007824682,
0.008513148,
-0.03368188,
-0.023222491,
-0.014643144,
0.031563524,
-0.0071494556,
0.027724,
-0.022825299,
-0.0059181605,
0.015093295,
-0.012167314,
-0.014272432,
0.000619785,
-0.009770922
] |
By analyzing gene expression data in glioblastoma in combination with matched microRNA profiles, we have uncovered a posttranscriptional regulation layer of surprising magnitude, comprising more than 248,000 microRNA (miR)-mediated interactions. These include ∼7,000 genes whose transcripts act as miR "sponges" and 148 genes that act through alternative, nonsponge interactions. Biochemical analyses in cell lines confirmed that this network regulates established drivers of tumor initiation and subtype implementation, including PTEN, PDGFRA, RB1, VEGFA, STAT3, and RUNX1, suggesting that these interactions | [
-0.031844657,
-0.0055695386,
0.009894121,
-0.02964305,
-0.016826559,
0.014598743,
-0.01450701,
0.0097172065,
-0.020797312,
-0.015699547,
0.009913779,
-0.005071556,
0.0125019755,
-0.007856325,
0.0003243437,
-0.0084460415,
0.026615841,
0.00476687,
0.008636061,
0.0138779795,
-0.017835628,
0.0215836,
-0.018123934,
-0.022251945,
-0.01450701,
0.03166119,
0.00476687,
-0.030770062,
-0.006722761,
-0.033364814,
0.007830116,
0.0090095475,
-0.013124454,
0.0095402915,
-0.0055990242,
-0.0053565856,
-0.0048586032,
-0.015332612,
0.017141074,
0.00041935348,
0.02901402,
-0.0041149063,
-0.004639098,
-0.009265091,
0.003865915,
-0.00427544,
0.03535674,
-0.0054843575,
-0.0026897595,
0.018805383,
0.00033273897,
-0.009966197,
-0.01385177,
-0.021753963,
-0.025908183,
0.018372925,
0.013471731,
0.02699588,
-0.010097246,
0.0073911054,
-0.009894121,
-0.016354786,
-0.025947498,
0.0073452387,
-0.013327578,
0.014061446,
0.020338645,
0.0065327412,
0.020561425,
-0.0123250615,
0.023588633,
0.019919291,
-0.0029698745,
-0.01174845,
0.0058152536,
-0.05991513,
-0.014284228,
0.0016266329,
-0.017468695,
0.013072034,
0.017901152,
-0.0008124974,
0.018137038,
0.0019264051,
0.008111869,
0.001200727,
-0.0066211983,
0.024034197,
0.011709136,
-0.016276157,
0.028647086,
0.022579564,
0.011840183,
0.009592711,
0.001249051,
0.0021770343,
-0.0075942297,
0.04112285,
0.0002627102,
-0.036011983,
-0.0055007385,
0.019539252,
-0.022789242,
-0.012351271,
-0.029171277,
-0.0055105668,
0.021491867,
-0.005972511,
0.024256978,
0.005507291,
-0.023339642,
0.021767067,
-0.009579606,
-0.030403128,
0.026497899,
0.017206598,
0.03092732,
0.011578088,
-0.009599264,
-0.0066605126,
0.030114822,
0.007535258,
0.014022132,
-0.02647169,
0.020731788,
0.015542288,
0.01161085,
0.0070503806,
-0.015122935,
0.013445522,
0.010071036,
0.007751487,
0.009114386,
0.0031189416,
-0.05142322,
-0.014572534,
0.00012859082,
-0.020771103,
-0.0037381432,
-0.030009985,
0.0010098884,
0.04188293,
-0.027520074,
-0.00038761532,
-0.018163249,
0.015594708,
0.014297334,
0.009297853,
0.022671297,
-0.009310958,
-0.012737862,
-0.023313433,
0.004409764,
-0.0068210466,
-0.01355036,
-0.0135241505,
0.014939468,
0.034413196,
-0.030848691,
0.00023383871,
0.014389067,
0.00004220666,
0.022802345,
0.033417232,
0.013229292,
0.021334609,
-0.017468695,
0.0022802346,
0.004819289,
-0.02095457,
-0.0021803104,
0.037086576,
-0.032552313,
0.010798353,
-0.007089695,
0.0072404,
0.008432937,
0.017010026,
-0.030743852,
-0.033810373,
0.0010926124,
0.008439489,
0.018739859,
0.004245954,
-0.01043797,
-0.013091692,
0.01177466,
-0.009278196,
-0.0013194892,
-0.032735784,
-0.017298331,
0.0149001535,
0.008609852,
0.0034694949,
-0.6399334,
-0.03024587,
0.03478013,
-0.010084141,
0.018700546,
0.02065316,
-0.019146107,
-0.01412697,
-0.009953093,
0.026288223,
-0.0023670539,
0.015948538,
0.0196703,
-0.02543641,
-0.007902192,
-0.037584558,
-0.014742896,
-0.021950534,
0.03166119,
0.0021917773,
-0.036378916,
0.014913258,
0.013995923,
0.029826516,
-0.006169083,
0.014349752,
0.01740317,
-0.009324063,
-0.010411761,
0.02417835,
-0.012462662,
0.0066080936,
-0.011001477,
0.018071514,
0.041175272,
-0.0053729666,
-0.007515601,
0.032788202,
0.006287026,
0.025580563,
-0.009605816,
-0.012056413,
0.030848691,
0.013760037,
-0.019906186,
0.026969671,
0.006034759,
-0.005857844,
0.009756521,
-0.0067031034,
-0.0054090046,
0.025960602,
-0.03346965,
-0.016669301,
0.01710176,
0.00967134,
0.018530183,
-0.01486084,
0.014769106,
-0.0136289885,
0.005543329,
0.013812455,
-0.008092212,
-0.012115384,
0.0109294,
0.0013588036,
-0.009992408,
0.0215836,
-0.0005729253,
0.022304364,
0.020744894,
0.016551359,
0.010837667,
0.008858843,
0.02765112,
0.02843741,
0.004075592,
0.024597703,
0.0014063085,
0.012180909,
-0.0081642885,
-0.012698548,
-0.036483753,
0.022907184,
0.015804384,
0.016878977,
-0.01669551,
0.004373726,
0.0014357943,
-0.0035841619,
-0.0056645484,
-0.0007686782,
-0.028830552,
-0.040310353,
-0.012999958,
0.012128489,
-0.004612888,
0.019368889,
0.033993844,
-0.03291925,
-0.017062446,
-0.0027176072,
0.019997919,
-0.004560469,
-0.00034379616,
-0.0017478522,
-0.035225693,
-0.0054090046,
0.0040723155,
-0.015227773,
0.010916295,
0.03352207,
-0.011230811,
-0.011342201,
-0.012495424,
-0.030639015,
0.007574572,
0.0049929274,
-0.022435412,
-0.03153014,
0.0037446956,
-0.005497462,
0.008046345,
0.0069979616,
0.022972709,
-0.00050781085,
0.004724279,
-0.016629986,
0.0059954445,
-0.0010541171,
0.0180322,
0.00691278,
0.014520114,
-0.029800307,
0.01642031,
0.0029878935,
0.014231809,
0.013432416,
-0.0094682155,
-0.025423305,
-0.02762491,
0.00022892441,
0.0042492305,
-0.0017707857,
-0.0048553273,
-0.0155684985,
-0.009101281,
0.004612888,
0.020640055,
-0.0073255813,
0.012770624,
-0.013484836,
-0.009409244,
0.017298331,
0.017481798,
-0.006287026,
-0.03158256,
-0.018870907,
0.000559411,
-0.024519075,
-0.015516079,
0.016158214,
-0.012121937,
-0.0020705578,
-0.01300651,
-0.03884262,
-0.015044306,
0.01576507,
-0.021767067,
-0.013799351,
0.010529704,
-0.015450555,
-0.017586637,
0.013681408,
-0.017822523,
0.005513843,
-0.0049110227,
0.013707617,
0.003323704,
-0.027965635,
-0.013904189,
-0.016407205,
-0.004544088,
0.0031549798,
0.033286184,
0.03745351,
0.03291925,
-0.009527187,
0.010713171,
0.0183074,
-0.022448517,
0.030481758,
-0.012344718,
0.048513956,
0.00096484064,
-0.031399094,
0.0123250615,
-0.0072272955,
-0.008708137,
0.019513043,
0.031058367,
-0.019657195,
-0.004783251,
-0.007371448,
0.0013997561,
-0.022081582,
-0.0008321546,
-0.021819487,
0.004806184,
-0.0025292258,
0.0043835547,
0.013773141,
-0.006627751,
-0.01934268,
0.014756001,
0.0031058367,
-0.010510047,
-0.008472251,
-0.009055414,
-0.027179347,
0.0109294,
0.005268128,
0.011905707,
-0.012252985,
-0.010641095,
0.014677372,
-0.000954193,
0.006398417,
0.0041738776,
-0.0026586356,
0.009953093,
0.014205599,
0.011931918,
0.0010148027,
0.0028961601,
-0.019879976,
0.004491669,
-0.02067937,
0.03863294,
0.0021622914,
-0.0068734656,
0.0051108706,
0.00595613,
-0.016407205,
0.010418314,
-0.009592711,
0.026969671,
0.0072993715,
-0.011322544,
0.0030485033,
0.006041311,
0.016852768,
-0.01191226,
-0.008000478,
0.005582643,
-0.016852768,
0.019054374,
0.023955569,
0.02576403,
0.004937232,
0.01417939,
-0.0017838904,
0.007882535,
-0.026917253,
-0.011191497,
0.008210155,
0.019054374,
-0.00016391234,
-0.01866123,
-0.0035481236,
-0.016944502,
-0.021622915,
0.013799351,
-0.04188293,
0.02256646,
-0.0039609247,
0.005248471,
0.022173315,
0.014926364,
0.013471731,
-0.014218705,
-0.0030337605,
0.0347015,
0.018857803,
-0.00885229,
-0.008878499,
-0.021478761,
-0.0026291497,
-0.0082691265,
-0.011132524,
0.029983774,
0.010595228,
0.016682407,
-0.00024530542,
-0.023483796,
-0.015935432,
0.018857803,
-0.03035071,
-0.0029027124,
-0.0032024847,
0.025580563,
-0.0062247785,
0.0049405084,
-0.014493905,
0.026288223,
0.009769626,
-0.008380517,
-0.01516225,
-0.02155739,
-0.018805383,
-0.0090095475,
0.01672172,
0.0018461383,
-0.027284186,
0.0034105233,
0.016236844,
0.025593668,
0.004314754,
-0.0010713171,
0.029878937,
-0.014651163,
-0.04568332,
0.0013727274,
0.004842222,
0.03354828,
0.016249947,
-0.018176353,
0.016996922,
0.0031844655,
-0.002796236,
-0.03803012,
-0.01898885,
0.000748202,
-0.024335608,
0.021164246,
0.019119898,
-0.0039052295,
-0.0027241595,
0.014756001,
0.020456588,
0.0025243114,
-0.032447476,
-0.014048342,
-0.00002469947,
0.008983338,
0.023890045,
0.01286891,
0.038973667,
0.027520074,
-0.014559429,
0.005546605,
0.03548779,
0.011925365,
0.0015946899,
0.0045178784,
0.02311686,
-0.0021131483,
0.024073511,
0.002747093,
-0.013183425,
0.037872862,
-0.00090259284,
0.018726755,
0.015516079,
0.0028208075,
0.019879976,
0.013353787,
0.003092732,
-0.0062575405,
-0.021006988,
-0.015175355,
0.016276157,
-0.009651682,
-0.044005908,
-0.007174876,
-0.006742418,
-0.002616045,
-0.014415276,
0.010614885,
-0.008157736,
0.009789283,
-0.008924367,
-0.005811977,
-0.021478761,
-0.010975267,
-0.020587636,
0.005248471,
-0.01942131,
-0.007456629,
-0.018818488,
0.00027724836,
-0.027126929,
-0.01161085,
-0.020823522,
0.019906186,
-0.02765112,
-0.039891,
0.006477046,
0.028568456,
0.0347015,
0.006781732,
-0.023038233,
0.00093044055,
0.016983816,
-0.0015373564,
-0.025515039,
0.009966197,
-0.02357553,
0.01735075,
-0.008649166,
-0.007456629,
-0.014520114,
-0.014756001,
-0.005644891,
-0.0005807063,
-0.0043016495,
0.03242127,
-0.0005721063,
0.003669343,
0.0036660668,
-0.0046947934,
0.015751965,
0.0045637456,
-0.019211631,
-0.00611994,
-0.026589632,
-0.024139035,
-0.027520074,
-0.009212672,
-0.02483359,
0.013956608,
0.00039744392,
-0.0107393805,
-0.002136082,
0.013812455,
0.0012891843,
0.00037225813,
0.016498938,
0.013838666,
0.01581749,
-0.0041509443,
0.0037709053,
-0.029354744,
0.00052378234,
-0.00621495,
-0.0025374163,
0.010804905,
-0.0034236282,
-0.019408204,
0.007718725,
-0.0062411595,
-0.0066375793,
-0.035304323,
0.00967134,
0.003174637,
0.044005908,
0.015175355,
-0.023274118,
-0.0041083535,
-0.010234846,
-0.005215709,
0.0037217622,
-0.012384033,
-0.014362857,
-0.020862836,
0.0036890002,
0.0049830987,
-0.0026684643,
0.012017098,
-0.035907142,
0.0052550235,
0.02906644,
0.012259537,
0.0013800989,
0.020194491,
0.00668017,
-0.018569497,
-0.023077548,
-0.031477723,
-0.038816407,
-0.015018097,
-0.0016749568,
0.059810292,
0.015738862,
0.038501892,
0.008400175,
-0.0033351707,
0.02674689,
0.029197486,
0.001629909,
-0.0044458024,
0.019984815,
-0.004069039,
0.0020443483,
0.007201086,
-0.0027045023,
0.02576403,
-0.009356825,
0.0054417667,
0.004511326,
-0.00674897,
-0.0075090486,
0.0009795836,
-0.013131007,
-0.034491826,
0.032368846,
-0.009514082,
0.022894079,
-0.040126886,
-0.011047344,
0.026484793,
-0.008970234,
0.020692473,
-0.0008194593,
0.021426342,
-0.004209916,
0.014100761,
-0.0036300286,
0.005513843,
-0.030770062,
-0.011486354,
-0.0053729666,
-0.024492865,
0.008839185,
-0.005297614,
0.042643007,
0.00934372,
-0.011886051,
-0.0007305924,
0.006925885,
-0.041463576,
-0.013615884,
-0.009789283,
-0.017809419,
-0.021465657,
-0.004888089,
-0.024492865,
-0.030062404,
-0.008138078,
0.01142083,
-0.005870949,
0.023510005,
-0.018294295,
-0.016472729,
0.028044265,
0.021649124,
0.026379956,
-0.0038102197,
0.019762034,
0.017639056,
0.003787286,
0.0042492305,
-0.011578088,
-0.0059102634,
-0.016643092,
0.023811415,
0.017206598,
-0.017442483,
-0.016957607,
0.01128323,
0.011945022,
0.0040297247,
-0.02609165,
0.009278196,
-0.0060314825,
-0.0055859196,
-0.003816772,
-0.016459625,
-0.028070474,
0.008878499,
-0.010084141,
0.01986687,
-0.01142083,
-0.012416795,
0.0020410721,
0.018949537,
0.0033286184,
0.00034011042,
-0.005854568,
-0.017508008,
-0.0010442885,
0.0011032601,
0.0023883493,
-0.004707898,
-0.014769106,
0.025606772,
-0.00093699293,
0.020613845,
0.0114798015,
-0.021701543,
0.011879498,
-0.016865874,
-0.008039793,
0.04510671,
-0.005264852,
-0.003983858,
0.01204986,
0.0040067914,
0.025934393,
-0.0012613367,
0.0019935672,
-0.008767109,
-0.01669551,
-0.0008014402,
0.023418272,
0.016708616,
-0.004979823,
0.0014816611,
-0.01866123,
-0.008413279,
-0.009651682,
-0.015673338,
0.011728793,
-0.04319341,
-0.017861838,
0.0007441067,
0.04694138,
0.008321546,
0.015227773,
-0.011820527,
-0.018503973,
0.026144069,
-0.0076138866,
0.021636019,
0.010863876,
-0.020456588,
-0.037007947,
0.005248471,
-0.005379519,
-0.040257934,
0.025724716,
-0.027520074,
-0.024270084,
-0.006287026,
-0.010057932,
0.018268086,
0.02472875,
-0.039052293,
-0.003141875,
-0.011990889,
0.01833361,
0.0023113585,
0.02412593,
-0.007653201,
-0.01292133,
0.0076400964,
0.0046751364,
0.012449557,
-0.0049241274,
-0.010411761,
-0.0072272955,
0.007685963,
-0.0040362775,
0.0079152975,
-0.019434413,
0.009297853,
-0.012757519,
0.016079586,
-0.007934954,
-0.02125598,
-0.014284228,
0.029197486,
0.0046816887,
-0.015371926,
-0.013353787,
0.013969713,
0.0058611203,
-0.0015897757,
-0.0072469525,
0.0074435244,
-0.00404283,
-0.038108747,
-0.04057245,
0.0102807125,
-0.020037234,
0.032447476,
0.008760557,
0.001018898,
-0.021439448,
-0.00041587252,
-0.045552272,
-0.022435412,
0.0229465,
0.023365851,
0.0012089175,
0.0071814284,
-0.00605114,
-0.015018097,
-0.016944502,
0.029669259,
0.026301326,
-0.013812455,
-0.00053197285,
-0.00008671689,
0.009756521,
0.0045309835,
-0.033024088,
-0.0061330446,
0.035042226,
-0.0061101113,
-0.02901402,
0.010700067,
-0.030429337,
0.020364854,
-0.0013424226,
-0.012927881,
-0.0075549153,
0.020181388,
0.033102717,
-0.027572492,
-0.001119641,
0.017062446,
0.007685963,
-0.018372925,
0.005779215,
-0.017717686,
0.018726755,
0.014153181,
0.00068841135,
-0.0065884367,
0.0063263406,
-0.0071355617,
0.0049994797,
0.0144414855,
0.017390065,
0.030167243,
0.012344718,
0.0064377314,
-0.021767067,
-0.0018297572,
0.010084141,
-0.0021246152,
0.019762034,
-0.0022114345,
-0.008642613,
-0.0027880454,
-0.012796834,
-0.023562424,
-0.0066703414,
0.016000956,
-0.023457587,
-0.025475724,
0.0037086573,
0.00474066,
-0.007089695,
-0.00095501204,
-0.009697549,
-0.009094729,
-0.040860757,
-0.0021491866,
-0.016983816,
-0.02447976,
0.007744935,
0.0046489267,
0.0064246263,
-0.00088293565,
-0.0076073343,
0.0034170756,
-0.021006988,
0.016367892,
0.18818487,
-0.019997919,
-0.020194491,
0.01385177,
0.00040583918,
-0.021269085,
0.032735784,
0.0026144069,
-0.005071556,
-0.0019591672,
-0.005071556,
0.0050912136,
-0.019762034,
-0.005281233,
0.009710655,
-0.015516079,
-0.029983774,
-0.0039936868,
-0.016367892,
0.002847017,
0.005975787,
0.0023932634,
0.0079152975,
-0.0075024962,
0.038423263,
0.010896638,
-0.0202207,
0.021740858,
0.007797354,
-0.00605114,
-0.023942463,
0.008695032,
0.0018346715,
0.0072207428,
0.016878977,
0.01289512,
-0.0058480157,
-0.0036988289,
-0.0045801266,
-0.025069475,
-0.0030501415,
0.032526106,
0.0007502496,
-0.012914777,
0.014402172,
0.0049568894,
-0.0043966593,
0.004724279,
-0.004786527,
-0.013969713,
-0.048015974,
0.026537213,
0.011755003,
0.032237798,
-0.0024833588,
-0.0011605936,
0.012829596,
0.01273131,
0.0018707097,
0.026511004,
-0.013301369,
0.009238882,
-0.03548779,
0.024899114,
-0.019748928,
0.028542247,
-0.016223738,
0.02223884,
0.02256646,
0.0033351707,
0.004802908,
-0.010516599,
-0.016498938,
-0.0080594495,
-0.013484836,
-0.015371926,
0.04521155,
0.009500978,
0.012233328,
0.018137038,
0.016014062,
0.006493427,
-0.02483359,
-0.011080106,
-0.0068865707,
-0.04072971,
0.018503973,
-0.00460306,
0.0018789002,
-0.006699827,
0.022645088,
-0.034622874,
-0.012757519,
0.00073264004,
0.018163249,
-0.0049274033,
-0.016118899,
0.0013907466,
-0.022802345,
-0.02254025,
-0.044530097,
0.07155219,
-0.014887049,
0.023090651,
-0.0039773057,
-0.0054876334,
-0.0035317426,
0.017494904,
0.0038691913,
0.005097766,
0.0036758955,
-0.019552356,
0.017337646,
-0.0119384695,
0.0025587115,
0.018766068,
0.018870907,
-0.02057453,
0.022828557,
-0.009324063,
-0.015529184,
-0.025659192,
-0.0019214908,
0.016669301,
-0.025934393,
0.014244914,
-0.037715606,
-0.0059463014,
0.0036758955,
-0.033338603,
0.007286267,
-0.008151184,
0.004347516,
0.0011622317,
0.009546844,
-0.02772975,
0.015240879,
0.008544328,
-0.004842222,
0.011440488,
-0.008701585,
-0.0060609686,
-0.014624953,
0.020194491,
-0.0073780003,
-0.0153588215,
0.018752964,
0.00808566,
-0.009815493,
-0.007771144,
-0.02825394,
-0.0062935785,
-0.008563984,
0.008944023,
0.028227732,
-0.0027176072,
-0.0068734656,
-0.02546262,
0.0059790635,
-0.0026537213,
-0.028463619,
0.0132423965,
0.028673295,
-0.020666264,
-0.008157736,
-0.0012130127,
-0.16407205,
0.0019640813,
0.024938429,
-0.020784207,
0.037532136,
0.017285226,
0.0114798015,
-0.0036791717,
0.010352789,
-0.000039519153,
0.031032158,
0.0048225652,
-0.026969671,
-0.018635022,
0.015686441,
0.002155739,
0.002037796,
0.043062363,
0.033286184,
0.012062965,
0.03865915,
-0.016682407,
-0.0026963118,
-0.014140075,
0.013760037,
0.009448558,
0.00019708385,
-0.016197529,
-0.004986375,
-0.0139828175,
-0.013294816,
0.0007633544,
0.015319508,
0.0023490349,
0.029800307,
0.012062965,
0.0032188657,
0.007056933,
-0.025973707,
0.0114798015,
0.03483255,
0.014611849,
0.0059299204,
0.012718205,
-0.003980582,
0.027677331,
0.020063443,
-0.014572534,
0.012986854,
0.009002996,
0.017822523,
-0.016603777,
0.009107834,
-0.004996204,
0.022409203,
0.02699588,
0.020731788,
0.0016413758,
-0.0075287055,
-0.014310438,
-0.007174876,
-0.016053377,
0.03931439,
0.0036890002,
0.004013344,
-0.030822482,
-0.009874464,
-0.0014841182,
-0.013511045,
-0.00014548372,
-0.034491826,
-0.01767837,
0.012685443,
-0.010090694,
0.0070700375,
0.018281192,
-0.0133472355,
0.020102758,
-0.0071159047,
0.0032614563,
-0.013537255,
0.016197529,
-0.027493862,
-0.0030222938,
0.0049405084,
-0.010274161,
0.021295294,
0.024309399,
-0.0008673737,
-0.017114865,
0.02218642,
-0.0054057287,
0.017940467,
-0.014926364,
0.030455546,
0.0076269917,
0.007967716,
0.00394782,
0.0036398573,
0.0009517358,
0.014375962,
-0.008622956,
-0.010418314,
0.008400175,
0.040834546,
-0.013733827,
-0.003685724,
0.016813453,
0.058290135,
-0.001628271,
-0.026969671,
-0.00803324,
0.0058643967,
0.02065316,
-0.010686962,
0.033731747,
-0.012705101,
-0.0020951293,
-0.03485876,
-0.012986854,
0.06505221,
0.004442526,
0.007633544,
0.019408204,
-0.009369929,
-0.036850687,
-0.1303141,
-0.03153014,
0.020548321,
0.010876982,
-0.02251404,
0.015778175,
-0.015856804,
0.02392936,
-0.020430379,
0.045316387,
-0.034465615,
-0.014703582,
-0.0071945335,
-0.0074238675,
-0.011984336,
-0.010411761,
-0.013045825,
-0.006827599,
-0.007908745,
0.026602738,
0.0028011503,
-0.0050944895,
-0.01349794,
0.0084460415,
0.0039445437,
0.015149144,
-0.021124933,
0.0040035155,
0.008570537,
-0.0014038513,
0.009402691,
-0.014035237,
0.028542247,
-0.016892083,
-0.019211631,
-0.018189458,
0.008118422,
-0.031766027,
0.008668823,
-0.0035677808,
0.003502257,
0.021020094,
0.020613845,
0.011191497,
-0.019486833,
-0.012475766,
-0.046653077,
0.004304926,
0.0052582994,
-0.002106596,
-0.02084973,
-0.025069475,
-0.014795315,
-0.026838623,
0.022002954,
-0.0058283582,
0.014140075,
0.017665265,
-0.016852768,
-0.010542809,
0.0044359737,
-0.0032958563,
-0.0111980485,
0.009193014,
0.00476687,
-0.0005401633,
-0.012384033,
-0.04694138,
0.019539252,
-0.007581125,
0.008505013,
0.0042000874,
0.0040723155,
-0.004491669,
-0.035776094,
0.014742896,
-0.011060448,
-0.051213544,
0.012462662,
-0.03095353,
-0.015869908,
-0.021727752,
0.010962162,
-0.02710072,
0.040913176,
-0.0043966593,
-0.0053664143,
-0.0073124766,
-0.006280474,
-0.008413279,
-0.008708137,
0.046338562,
-0.014585638,
-0.011971232,
-0.0029043506,
0.018635022,
-0.0063361693,
-0.009854807,
0.0012424985,
0.02084973,
-0.010175874,
-0.010922848,
-0.038370844,
0.011152182,
-0.0051534614,
0.0012351271,
0.02699588,
-0.02571161,
0.005743177,
-0.0015439088,
-0.027441444,
0.010064484,
-0.016551359,
0.0068538086,
-0.014205599,
-0.0035841619,
-0.024309399,
-0.009428902,
0.03616924,
-0.007843221,
0.014362857,
0.02838499,
-0.0023670539,
0.012207118,
0.013183425,
-0.0025587115,
-0.0031025605,
-0.023103757,
-0.018005991,
0.03732246,
-0.032578524,
-0.012737862,
0.0063558263,
-0.008485355,
-0.002170482,
-0.0052222614,
-0.0029551317,
-0.026524108,
0.018752964,
0.030376919,
0.01486084,
0.024047302,
-0.010352789,
-0.041384947,
-0.0023293777,
0.004377002,
0.01969651,
0.029983774,
-0.03226401,
-0.015227773,
-0.012226775,
-0.012967196,
0.022985814,
0.017245913,
-0.006070797,
-0.03354828,
-0.008668823,
-0.008144631,
-0.0025128447,
-0.025868868,
-0.018818488,
-0.025829554,
0.022802345,
0.029931355,
-0.02221263,
-0.012619919,
0.008111869,
0.012809939,
-0.02472875,
0.0029600458,
0.011099762,
-0.03750593,
-0.017652161,
-0.006978304,
0.013248949,
0.0045834025,
0.017743895,
-0.01286891,
-0.021793276,
0.00450805,
-0.00618874,
0.03153014,
0.02510879,
0.007993926,
-0.008793319,
0.012030203,
0.01177466,
0.0012326699,
-0.0015914137,
0.005235366,
0.0080594495,
-0.0004558012,
-0.015450555,
0.012436452,
-0.0010565742,
0.0072272955,
0.01710176,
0.024322502,
-0.001019717,
0.009632026,
-0.010077588,
0.025370887,
0.006368931,
0.011086658,
0.004069039,
-0.006840704,
-0.017232807,
0.026458584,
-0.021347715,
-0.027336605,
-0.0020672816,
-0.0070176185,
0.0019133002,
0.016577568,
-0.010962162,
-0.014310438,
-0.019801348,
0.02609165,
-0.008190498,
-0.02155739,
-0.011827079,
0.041542206,
0.027231768,
0.01062799,
0.01125702,
-0.0064377314,
0.01579128,
0.024060406,
0.011427383,
-0.02898781,
0.041568413,
-0.0064573884,
0.0085181175,
-0.002994446,
-0.033259973,
-0.011853289,
-0.0079873735,
-0.017560428,
-0.014074552,
0.018202562,
-0.010778695,
0.082036026,
-0.00014783848,
-0.015201564,
0.011165286,
-0.019329576,
0.029826516,
0.012986854,
0.016118899,
-0.03289304,
-0.03402005,
0.012410242,
-0.023601739,
0.016918292,
-0.040231727,
-0.0014251466,
0.034360778,
-0.02032554,
0.035802305,
-0.0061101113,
-0.012757519,
0.008400175,
-0.0041050776,
0.0103855515,
0.0091537,
-0.026563423,
-0.0034400092,
0.02160981,
0.02024691,
0.00018295525,
-0.041647043,
-0.001415318,
-0.0056842053,
-0.037191413,
-0.0011294696,
0.0076269917,
0.00045907742,
-0.008806423,
-0.021216666,
0.030586595,
0.021688439,
0.026327536,
-0.0053926236,
-0.015306402,
-0.015529184,
0.017455589,
-0.013471731,
-0.019486833,
-0.02672068,
-0.00726661
] |
The simple yet powerful technique of induced pluripotency may eventually supply a wide range of differentiated cells for cell therapy and drug development. However, making the appropriate cells via induced pluripotent stem cells (iPSCs) requires reprogramming of somatic cells and subsequent redifferentiation. Given how arduous and lengthy this process can be, we sought to determine whether it might be possible to convert somatic cells into lineage-specific stem/progenitor cells of another germ layer in one step, bypassing the intermediate pluripotent stage. Here we show that transient induction of the four reprogramming factors (Oct4, Sox2 | [
-0.0060049244,
0.010975759,
-0.0056645907,
-0.017343923,
-0.019804796,
0.0014153296,
-0.016597807,
0.0025492294,
-0.020734169,
-0.012219285,
0.010785957,
0.024464749,
-0.0056744083,
0.01693814,
-0.015537538,
0.01540664,
0.0403688,
0.0017523908,
-0.0042083557,
0.021388657,
-0.040028468,
0.0024101508,
0.011191739,
-0.010098745,
-0.01754027,
0.025747545,
-0.0003836934,
-0.020498553,
-0.012049118,
-0.006345258,
0.0054878793,
0.000018688692,
-0.005396251,
-0.008272724,
-0.009876219,
-0.013122478,
-0.00952934,
-0.008397077,
-0.0042738044,
-0.012094933,
0.015707703,
0.014765242,
-0.0137966005,
-0.007173185,
0.0019601905,
0.0030711833,
-0.02015822,
-0.0121996505,
-0.009051564,
0.017330833,
0.031651024,
-0.0077360445,
-0.0072975378,
-0.0010561795,
-0.027514663,
-0.023928069,
-0.0101576485,
0.017841334,
0.024176775,
-0.0076836855,
-0.0017932962,
0.0055860523,
-0.013214106,
0.019765528,
-0.011728419,
0.0191634,
-0.014909229,
0.0003791938,
0.01543282,
-0.007644416,
0.033300333,
0.009647149,
0.009712597,
-0.013129023,
0.011106656,
-0.019765528,
-0.021598093,
-0.017671168,
0.001530683,
0.012952311,
0.01587787,
-0.026991071,
-0.011780778,
0.019529913,
-0.003426243,
0.013115933,
0.0036585862,
0.025721366,
0.011185194,
0.0029206513,
0.016532358,
0.03764613,
0.026244955,
0.002941922,
-0.011636791,
0.0151972035,
-0.0002605679,
0.0318081,
-0.00846907,
-0.031965178,
-0.014909229,
0.01089722,
0.008658872,
-0.022998696,
-0.044819314,
0.006060556,
0.026140237,
0.0064008893,
0.028849816,
0.015157934,
-0.021427926,
0.022933248,
0.012160381,
-0.032672025,
0.040185545,
-0.0063125337,
0.0054780617,
0.010707418,
-0.0297661,
-0.0067084986,
0.026650738,
0.02013204,
0.01640146,
-0.02701725,
0.022776172,
0.015027037,
-0.018273296,
0.015812423,
-0.009208642,
-0.000746525,
0.025786815,
-0.018875424,
-0.0063943444,
0.03594446,
-0.012369817,
-0.011839682,
0.016309833,
0.0046795867,
-0.016767975,
-0.032148436,
-0.00901884,
0.010458713,
0.0024445115,
-0.0051606353,
-0.016021859,
0.0060572834,
0.01755336,
-0.01966081,
0.020145131,
0.008717776,
-0.0031922637,
-0.0059623825,
0.035761207,
-0.00873741,
-0.010936489,
0.019752437,
0.032122254,
0.018103128,
-0.03447841,
0.0114535345,
-0.0068786656,
-0.012939221,
0.009012295,
0.011715329,
0.0008344718,
0.023430659,
-0.0002965647,
0.019255027,
0.00877668,
-0.0004659134,
-0.019713169,
0.019608451,
-0.045997392,
0.019988054,
-0.011178649,
0.0031709927,
-0.0033035264,
0.0063321684,
-0.027724098,
-0.02869274,
-0.0018129308,
0.020616362,
0.016034948,
0.02604861,
-0.006256902,
-0.017278474,
0.006083463,
-0.013482446,
-0.0059754723,
-0.023168864,
-0.006639777,
0.02125776,
-0.0033477044,
-0.00005829031,
-0.63752335,
-0.03976667,
0.029163972,
-0.012638157,
0.03335269,
0.042279903,
0.0037731214,
-0.014254741,
-0.018116219,
0.01543282,
-0.0044897855,
0.00465668,
0.018783797,
-0.020904336,
-0.006695409,
-0.025106147,
-0.007978205,
-0.004352343,
-0.00011750099,
-0.0027210326,
-0.017985322,
-0.007218999,
-0.034792565,
0.022514377,
0.0093591735,
0.0140976645,
0.012906497,
-0.013155202,
-0.017644988,
0.038038824,
-0.022959428,
0.0020829071,
-0.0023937887,
-0.01488305,
0.04576178,
0.014110754,
-0.022213312,
0.016270563,
0.023496108,
0.056966607,
-0.010242732,
-0.010491437,
0.011748054,
0.01541973,
-0.0143987285,
0.0054387925,
0.0058053057,
-0.0014447815,
-0.018613629,
-0.005137728,
0.020773439,
0.011630246,
-0.032619666,
0.0068197614,
0.00954243,
0.00979768,
0.0059394757,
-0.009077744,
0.012369817,
-0.0045715966,
0.0024068784,
0.026127148,
-0.027436124,
-0.016414551,
0.0077360445,
0.021977697,
-0.009915488,
-0.019307386,
0.007801493,
-0.021859888,
0.007441525,
0.020014234,
-0.03285528,
-0.0013392454,
-0.029111613,
0.028247688,
-0.0014791421,
-0.0027750276,
0.0037305797,
-0.004561779,
0.016872693,
-0.01956918,
-0.009319904,
0.019765528,
0.018391104,
0.009745321,
-0.0095817,
0.02288089,
-0.012389451,
0.0039007466,
0.013770421,
0.0153935505,
0.0033133437,
-0.06581528,
-0.026807815,
0.010072566,
-0.007847307,
-0.0040872754,
0.00026833994,
-0.025341762,
-0.009692962,
0.017121397,
0.027226686,
0.015550627,
0.017906783,
0.001142081,
-0.039504874,
-0.006839396,
0.04256788,
-0.028928354,
0.0035735026,
-0.018823065,
0.012474535,
0.004718856,
-0.012513804,
-0.014935409,
0.0017556632,
-0.0031938998,
-0.0074480698,
-0.024530198,
0.022684542,
-0.02653293,
-0.0021287212,
0.031415407,
0.00051377283,
0.010255822,
0.000589857,
-0.00424108,
0.026912533,
0.0003270393,
-0.01248108,
-0.03233169,
0.005226084,
-0.031022716,
0.0028110247,
0.003746942,
0.014294011,
-0.009064654,
0.01905868,
-0.023587735,
-0.025302494,
-0.008901033,
0.006315806,
-0.015380461,
-0.00849525,
-0.015694614,
-0.02175517,
-0.011571342,
0.015589897,
-0.012081843,
0.003740397,
-0.0020256394,
0.002544321,
0.0019225576,
0.020485464,
-0.0098565845,
-0.0047744876,
-0.024896711,
-0.0020092772,
-0.024346942,
-0.02764556,
0.034792565,
-0.0055500553,
0.020066593,
0.0041298172,
-0.03138923,
-0.029635202,
0.006060556,
-0.017239206,
-0.021519555,
0.006904845,
-0.012422176,
-0.021964606,
0.02175517,
-0.023797171,
0.009280635,
0.005942748,
-0.002470691,
0.0027161238,
0.0002509551,
-0.02013204,
-0.03453077,
-0.0019961875,
-0.0070488323,
0.033247974,
0.00084183476,
0.02498834,
0.0063485303,
0.01168915,
0.03434751,
-0.001992915,
0.0137966005,
0.011001938,
0.015000857,
0.020393835,
-0.0028715646,
-0.00371749,
0.016545448,
-0.0026441303,
0.016898872,
0.022095503,
-0.013358094,
-0.008292358,
-0.02971374,
0.024608737,
-0.031127434,
0.008953392,
-0.01853509,
0.0052424464,
0.022776172,
-0.0077884034,
0.009679873,
-0.026244955,
-0.023797171,
0.0021041778,
0.0018718347,
0.004712311,
-0.0017883875,
-0.0045879586,
-0.0012328911,
-0.0068197614,
-0.007585512,
0.013358094,
-0.01113938,
-0.0129261315,
0.020524733,
0.0016141302,
0.010661604,
0.013443177,
-0.015066306,
0.003321525,
0.013201016,
0.0069375695,
-0.0043130736,
0.02661147,
0.0371749,
0.013783511,
-0.018692167,
0.048589166,
-0.010517617,
-0.0057660365,
0.019241938,
-0.005733312,
-0.0008152462,
-0.0117545985,
0.016558537,
0.043196186,
0.006787037,
-0.01088413,
0.018181667,
-0.0351329,
0.0071862745,
-0.031939,
0.004597776,
0.013148657,
-0.02549884,
0.0011887132,
0.016702525,
0.020930516,
0.015367371,
-0.004470151,
-0.025367942,
0.002493598,
-0.021532644,
-0.0057365843,
0.011237553,
0.014359459,
-0.014477267,
-0.011486258,
-0.0038942017,
-0.031651024,
0.010825226,
0.018312566,
-0.028038252,
0.00003073024,
-0.00305973,
0.0058543924,
-0.0011314455,
0.015864782,
-0.009496616,
-0.012867228,
-0.016741795,
0.017357012,
0.015144845,
0.00003607352,
0.008894487,
-0.032253154,
-0.030106433,
0.004247625,
-0.0033640666,
0.00244942,
-0.010183828,
0.0054682447,
0.014673614,
-0.0040283715,
-0.029923176,
-0.006479428,
-0.0037502144,
0.040709134,
0.0043916125,
0.025891533,
-0.013639523,
-0.004015282,
-0.016021859,
0.0444528,
0.019255027,
-0.015445909,
-0.020917427,
-0.009064654,
-0.027567022,
-0.014922319,
-0.0159695,
-0.011237553,
-0.013430087,
0.0029844637,
-0.006256902,
0.0031137252,
0.016152756,
0.02387571,
0.007546243,
-0.015040127,
-0.027881175,
-0.008462526,
-0.0057234946,
0.045369085,
0.035289977,
-0.01139463,
0.015445909,
-0.0037076727,
-0.014437998,
-0.010975759,
-0.033562128,
0.030734742,
-0.02814297,
0.012402541,
0.0117022395,
0.011119746,
-0.020328388,
-0.005383161,
0.02921633,
-0.007101191,
-0.015223383,
-0.0136002535,
-0.011198284,
-0.00371749,
-0.00069743843,
-0.0058707544,
0.022959428,
0.022213312,
-0.004741763,
0.03235787,
0.009077744,
-0.024019698,
0.010412899,
-0.031127434,
0.010196918,
-0.0070815566,
-0.0009817315,
-0.009097379,
-0.03827444,
0.00048309373,
0.02116613,
-0.015589897,
0.01168915,
0.017147576,
0.020446194,
0.011486258,
-0.009535885,
0.0004450516,
-0.0046403175,
-0.02553811,
-0.008658872,
-0.002045274,
-0.03992375,
0.0076575056,
-0.0101576485,
-0.028588021,
-0.015668435,
0.0021827165,
0.0128017785,
0.0031938998,
-0.009882764,
-0.0120033035,
0.01062888,
-0.009404988,
-0.029975535,
0.022108594,
-0.0016533994,
-0.015171024,
-0.00846907,
-0.0024232406,
-0.013613343,
-0.024634916,
-0.009261001,
0.023064146,
-0.029033072,
-0.029635202,
0.01223892,
0.018770706,
0.030446766,
0.016951231,
-0.014372549,
-0.007840762,
0.021362478,
0.0067739473,
-0.045447625,
0.005137728,
-0.022606004,
0.011322637,
0.012782144,
-0.007487339,
-0.023312852,
-0.0058183954,
0.008292358,
0.025616648,
-0.00610637,
-0.012022939,
0.0013269738,
-0.008266179,
0.032174613,
0.04044734,
-0.0021303573,
-0.00771641,
-0.010445624,
-0.009457347,
-0.03026351,
-0.017199935,
-0.037934106,
-0.013731152,
-0.011231009,
-0.0069833836,
-0.013665702,
-0.023103414,
-0.019830976,
0.028718919,
-0.012651247,
0.031048896,
-0.0017900238,
0.008344718,
0.020420015,
-0.004470151,
0.017226115,
0.023037966,
0.004218173,
-0.006054011,
-0.016152756,
0.044191007,
0.007003018,
-0.028823636,
-0.017487912,
0.023928069,
-0.011388086,
-0.027776457,
-0.0064270687,
-0.016362192,
0.029399587,
-0.018482732,
-0.006859031,
-0.020459285,
0.003485147,
0.009247911,
0.03824826,
0.022907069,
-0.03275056,
0.010929944,
0.014830691,
0.009778046,
-0.007762224,
0.020341476,
-0.04091857,
0.0018718347,
0.020092772,
0.032829102,
-0.0016133122,
-0.000642216,
0.009097379,
-0.0050068307,
-0.017854424,
-0.0034426053,
-0.021519555,
0.0027144877,
-0.030734742,
0.043955393,
0.0468875,
0.02767174,
0.007624781,
-0.00046305003,
0.0059067514,
0.003665131,
0.0038123906,
0.005687498,
0.011715329,
-0.0222264,
0.026428211,
-0.0019749166,
0.004944654,
0.020734169,
-0.023129594,
0.016794154,
0.024124416,
-0.015982589,
-0.025865354,
0.021624273,
-0.037750848,
-0.040604416,
-0.003874567,
-0.008743956,
-0.004424337,
-0.030394407,
0.015053216,
0.005883844,
-0.0024379666,
-0.0027930262,
0.0051639075,
0.041546877,
0.011865862,
0.006679047,
-0.0017033041,
0.008665416,
-0.018469643,
0.005874027,
-0.020210579,
0.0011985305,
-0.005762764,
0.0018832883,
0.0047286735,
0.010236187,
-0.00020207308,
-0.0014987767,
0.032593485,
-0.02653293,
-0.020276029,
-0.01138154,
-0.035499413,
-0.004555234,
-0.0034491501,
-0.012716696,
-0.0098565845,
-0.014490357,
-0.0009931851,
-0.029687561,
0.0048693884,
-0.014830691,
-0.011885496,
0.022475107,
-0.006292899,
0.0006733042,
0.0005338165,
0.033038538,
0.03814354,
0.011780778,
-0.023954248,
-0.031048896,
-0.010458713,
-0.004440699,
0.029530484,
0.021349387,
0.0056613185,
-0.041599236,
-0.0027930262,
-0.005337347,
-0.030970357,
-0.022619095,
-0.008030564,
-0.01138154,
-0.0024985068,
0.004473423,
-0.010425989,
-0.016506178,
0.016506178,
0.008711231,
0.023535376,
0.00041334986,
-0.0035211437,
-0.034295153,
0.031572487,
-0.004538872,
0.004934837,
0.014280921,
0.002732486,
-0.011564797,
-0.030787101,
-0.013207561,
0.0035342334,
-0.008436346,
0.019608451,
-0.020262938,
0.0017687529,
0.018613629,
0.010144559,
0.00026813542,
-0.005317712,
0.009902398,
0.040002286,
-0.014136934,
-0.004725401,
0.0054911515,
-0.0020207306,
0.022043144,
-0.026467482,
-0.004830119,
0.008168006,
-0.03233169,
-0.0025017792,
0.03987139,
0.017880604,
0.014189293,
0.0056842254,
-0.013901318,
-0.00981077,
-0.033143256,
-0.03599682,
0.0034524226,
-0.018823065,
0.02024985,
0.0026604924,
0.023993518,
0.009575155,
-0.0107794115,
0.016519269,
0.018796885,
0.014071485,
-0.013292645,
0.023810262,
0.029163972,
0.016270563,
-0.019516822,
0.010033296,
-0.009699508,
-0.015144845,
0.0007592057,
-0.024556378,
-0.029137792,
0.008613057,
0.007893122,
0.015105575,
-0.011100111,
-0.017762795,
-0.00358332,
0.01644073,
0.0109561235,
0.00383857,
-0.023548467,
-0.019333566,
-0.023522288,
-0.00011842136,
0.015341191,
-0.026964892,
0.0015740428,
-0.019359745,
0.0029271962,
0.022121683,
-0.013305735,
0.0026784907,
0.0020763623,
-0.016702525,
0.0040676408,
0.014739063,
0.005203177,
0.0027390309,
-0.019909514,
-0.00818764,
-0.002305433,
-0.021611184,
-0.029451946,
0.0056384113,
0.011532073,
0.0072386335,
-0.008266179,
0.00055590546,
-0.015589897,
-0.029923176,
-0.02339139,
0.0022285306,
-0.02124467,
0.041232724,
0.030394407,
0.0025017792,
-0.026663829,
0.004270532,
-0.06434923,
-0.0140976645,
0.018980142,
0.015000857,
0.008122192,
0.013266465,
-0.0054813344,
-0.021126863,
0.00020278891,
0.015013947,
0.0034589674,
-0.025786815,
0.015917141,
0.018967053,
0.011198284,
0.00371749,
-0.030080253,
-0.010517617,
0.016807243,
-0.007631326,
0.015733883,
0.012356727,
-0.006420524,
0.055134043,
-0.009712597,
0.030917998,
0.0222264,
0.029923176,
0.020354567,
-0.026153328,
-0.0034720572,
0.014437998,
-0.010491437,
-0.0047286735,
-0.0021598092,
-0.016126577,
-0.010432534,
-0.008246545,
0.0035145988,
-0.014634345,
-0.013875139,
-0.014909229,
0.026323494,
-0.0022890707,
0.005795488,
0.012487625,
0.0031415408,
-0.00009940031,
-0.0110281175,
0.0074022557,
-0.0015372279,
-0.00981077,
0.01271015,
-0.01587787,
0.005137728,
0.013534805,
-0.008416711,
-0.026860174,
-0.013521715,
-0.0011666242,
0.0023856075,
-0.0010962669,
0.029163972,
-0.006449976,
-0.020616362,
-0.01271015,
0.0017262113,
-0.015249562,
-0.029661382,
-0.015838603,
-0.0010185464,
-0.014922319,
0.0086326925,
-0.011433899,
0.001611676,
-0.011610611,
0.008534519,
0.010223097,
0.0067543127,
0.009221732,
0.20503789,
-0.0067215883,
0.0143071,
0.015040127,
0.00399892,
-0.0059460206,
0.013358094,
-0.0041101826,
-0.0077360445,
-0.004836664,
0.007487339,
0.014974678,
-0.0025623192,
-0.011211374,
0.0297661,
-0.029033072,
0.00015820195,
-0.009352629,
-0.01696432,
-0.008868308,
0.0143071,
-0.015249562,
-0.0032298968,
-0.004002192,
0.019948784,
0.0020714535,
-0.007840762,
0.022645274,
0.020105861,
0.008887943,
-0.028090611,
0.01640146,
0.00570386,
0.016231295,
0.019425195,
-0.012454901,
0.018823065,
-0.036023002,
0.0038451152,
-0.020851977,
0.012919587,
0.0130504845,
0.00089337566,
-0.008907577,
-0.010635424,
0.024085147,
-0.007925846,
0.0074611595,
0.02443857,
0.0005231811,
-0.022108594,
0.011545163,
0.009346084,
0.007624781,
0.016911961,
-0.01195749,
0.007880031,
0.018260207,
0.013384273,
0.023784082,
-0.00610637,
0.0091824625,
-0.033195615,
0.024019698,
-0.0069768387,
0.008266179,
-0.0035473232,
0.0007661596,
0.021598093,
-0.010138014,
-0.015380461,
0.0075069736,
-0.02547266,
0.006741223,
-0.0054158857,
-0.029059254,
0.0532753,
0.009751867,
0.01853509,
0.013318825,
0.017828245,
0.012559619,
-0.028038252,
0.0008442891,
-0.00054649723,
-0.020577092,
0.025394121,
0.006129277,
-0.03987139,
-0.0027488482,
0.0013678792,
-0.013508625,
-0.0013637887,
-0.014254741,
0.005000286,
-0.001963463,
0.017265385,
0.007160095,
0.020734169,
-0.0143071,
-0.024333851,
0.06304025,
0.015485179,
0.023548467,
-0.004365433,
0.021663543,
0.021427926,
-0.002491962,
-0.010203463,
-0.0032888006,
0.016074218,
-0.015262652,
0.010275456,
-0.0040185545,
0.005419158,
0.020498553,
-0.0072451783,
-0.040185545,
0.044924036,
0.014686704,
-0.004051279,
-0.021886067,
-0.0046337727,
0.012193105,
-0.00820073,
0.0011118109,
0.00077147735,
0.010511072,
-0.03280292,
-0.013129023,
-0.013305735,
-0.011067387,
0.012422176,
0.014935409,
0.007808038,
-0.005150818,
0.005867482,
-0.0012296187,
-0.0136002535,
0.0018374742,
-0.018679079,
0.0024068784,
0.0035440507,
0.0026457664,
0.010452168,
-0.00625363,
0.009247911,
0.023627006,
-0.0052489913,
-0.028038252,
-0.013253375,
-0.021859888,
-0.00040700953,
-0.0059525655,
0.023731723,
-0.0083839875,
-0.007218999,
-0.023077235,
0.006204543,
0.015013947,
-0.020236759,
0.031022716,
0.005798761,
-0.014581986,
-0.01593023,
-0.03175574,
-0.16336012,
-0.013718062,
0.034556948,
-0.010321271,
0.027488483,
0.0070357425,
0.01036054,
-0.0007367077,
-0.008266179,
0.0016754884,
0.0148961395,
0.015066306,
-0.038640954,
-0.012121112,
0.00069007545,
0.014032216,
-0.009928578,
0.05107622,
-0.00039453336,
0.010864495,
0.022566736,
-0.0026637649,
0.017435553,
0.009882764,
0.016754884,
-0.020066593,
-0.0017000317,
-0.019529913,
-0.025210865,
-0.040525876,
-0.004771215,
0.0023937887,
0.020564003,
-0.015118665,
-0.00016229249,
-0.000455278,
0.003642224,
-0.0007420254,
-0.004702494,
0.026244955,
0.024569467,
0.00083283556,
0.0054355203,
-0.0041167275,
-0.0061096423,
0.02767174,
-0.017893692,
-0.022723813,
0.016623987,
-0.0037044003,
0.013240285,
-0.012742875,
-0.034268975,
0.01244181,
0.03604918,
0.009647149,
0.034426052,
0.0039825574,
-0.00023541103,
-0.0066332323,
-0.013940588,
0.0011396266,
0.038536236,
-0.0034655123,
-0.00743498,
-0.027462304,
0.012782144,
0.009411532,
-0.020328388,
0.008344718,
-0.013613343,
-0.0015625893,
-0.00031313146,
-0.018993232,
0.023522288,
0.0011813502,
-0.0024232406,
-0.009254456,
0.0063877995,
-0.0041265446,
-0.032672025,
0.0371749,
-0.013639523,
-0.006407434,
-0.029949356,
0.01587787,
0.01912413,
0.0114011755,
-0.023770992,
-0.008416711,
0.019961875,
-0.02924251,
-0.0033346147,
-0.0047319457,
0.02332594,
0.008567244,
-0.009961302,
-0.020511644,
-0.014542717,
0.0072255437,
0.025079967,
0.0026081335,
-0.0093068145,
0.0044832407,
0.04934837,
-0.00068721204,
-0.023339031,
0.012134202,
0.039504874,
-0.007389166,
-0.010353995,
-0.00049454725,
-0.0043032565,
0.011721875,
-0.0077229547,
0.039531056,
-0.004771215,
0.008082923,
0.002761938,
-0.012919587,
0.05534348,
0.005942748,
0.00797166,
0.033143256,
-0.008390532,
-0.0075658774,
-0.13529569,
-0.010890675,
0.0025557743,
0.028561842,
-0.014778332,
0.022514377,
0.0011093566,
0.01433328,
-0.01913722,
0.014804511,
-0.015681524,
-0.04924365,
0.0106550595,
-0.021074504,
0.017186847,
0.0018947418,
-0.0013179745,
-0.0016411279,
-0.022383478,
0.03199136,
0.0035800475,
0.0011707149,
-0.013456266,
-0.006970294,
0.006747768,
0.030420586,
-0.04780378,
0.0123763615,
0.031415407,
0.032226972,
0.012618522,
-0.014359459,
0.019490642,
0.005887117,
0.0038614774,
-0.0015560444,
0.0070488323,
-0.03070856,
0.029451946,
-0.012121112,
-0.0054518823,
0.0024837807,
-0.01034745,
-0.011610611,
0.00091546465,
-0.0073629864,
-0.008305449,
0.005988562,
0.0076575056,
-0.014843781,
-0.0373058,
-0.020472374,
-0.016270563,
0.00042459887,
0.009843495,
-0.028771278,
0.004604321,
0.007003018,
-0.0035735026,
-0.006076918,
-0.004054551,
-0.016283654,
-0.015812423,
-0.029321048,
0.024346942,
-0.013678792,
-0.020825798,
-0.035970643,
0.031232152,
-0.010386719,
-0.019268118,
0.000805838,
-0.015027037,
0.016008768,
-0.019438284,
0.00027815727,
-0.007912756,
-0.008940302,
-0.0053995233,
-0.01595641,
-0.016139666,
-0.02598316,
0.012644702,
-0.011793868,
0.02066872,
0.00066635024,
0.017618809,
-0.014621255,
0.007428435,
0.0018227482,
-0.0023430658,
0.024556378,
-0.006950659,
-0.02175517,
0.003076092,
-0.004142907,
0.000806247,
0.0017458459,
0.026297314,
0.030603843,
-0.0037600317,
-0.017762795,
-0.04835355,
0.02551193,
-0.005785671,
-0.014123844,
-0.005029738,
-0.016034948,
0.010556886,
-0.0037142176,
0.006073646,
0.006391072,
-0.018194757,
0.0063943444,
-0.031493947,
0.0014374185,
-0.031467766,
-0.015851691,
0.03086564,
-0.0066463226,
-0.0027832089,
0.0045781415,
0.000634444,
-0.022462018,
0.012291279,
-0.0056842254,
-0.008783225,
0.014621255,
-0.00873741,
0.03612772,
-0.00952934,
-0.01595641,
0.012605432,
-0.035289977,
-0.02447784,
0.006502335,
-0.011374996,
-0.0010774503,
0.023705544,
0.026781635,
0.023653185,
0.045028754,
-0.0009719142,
-0.026297314,
0.018901603,
-0.010210007,
-0.0066332323,
0.011316092,
-0.014019126,
0.023195043,
0.0013556076,
-0.015157934,
0.032488767,
0.013678792,
-0.0117545985,
-0.0015004129,
-0.013070119,
-0.028745098,
0.0028355678,
0.0051050037,
-0.010589611,
-0.0015854964,
0.024189865,
0.009241366,
0.014948498,
0.0013695154,
-0.01595641,
-0.015616076,
-0.015851691,
0.012886862,
-0.01962154,
-0.011316092,
-0.013757331,
0.038352977,
0.013377728,
0.0068197614,
0.003426243,
-0.00004673451,
-0.01272324,
0.0021908975,
-0.0128017785,
0.016113486,
0.002208896,
0.013233741,
-0.024373122,
0.014922319,
0.037227258,
0.0109234,
-0.00064998807,
0.025407212,
-0.011224464,
-0.0051540905,
0.009411532,
-0.004663225,
-0.0086326925,
0.0062339953,
0.025669007,
0.011440445,
-0.021990785,
0.024045877,
0.0047319457,
0.020302208,
-0.000039473787,
0.020603271,
0.03191282,
-0.027357584,
-0.024085147,
0.009293725,
-0.022174042,
-0.034714025,
-0.027357584,
-0.016192025,
-0.014621255,
0.01755336,
-0.014267831,
-0.0027439396,
-0.029033072,
0.010275456,
0.002537776,
-0.030106433,
-0.0050493726,
0.03453077,
0.020367656,
0.010131469,
0.0061325496,
0.011276823,
0.0025017792,
0.0041527245,
0.023430659,
0.003992375,
0.027854996,
0.015917141,
0.0190325,
0.016571628,
-0.0017785702,
-0.019503733,
-0.009280635,
-0.025354853,
0.004614138,
0.024543287,
-0.008770135,
0.06701954,
0.0066463226,
-0.03505436,
-0.0023496107,
-0.016126577,
0.027802637,
0.0016697617,
0.018260207,
-0.034268975,
-0.025302494,
0.02391498,
-0.016689437,
0.022606004,
-0.016178936,
-0.007585512,
0.011950945,
-0.018692167,
-0.0026932168,
-0.008959936,
-0.01168915,
0.0024117872,
-0.01113938,
0.0060900077,
0.020917427,
-0.021650452,
-0.024150595,
0.021336298,
-0.010569976,
0.009418078,
-0.0047319457,
-0.0012418904,
0.00798475,
-0.043615058,
-0.019935695,
-0.0110281175,
0.012271644,
0.0026310405,
-0.022422748,
0.028221508,
0.019608451,
-0.011512438,
0.006220905,
-0.015171024,
-0.017959142,
-0.011185194,
0.00799784,
-0.010740142,
-0.010183828,
0.015040127
] |
Dysfunction of the pancreatic beta cell is an important defect in the pathogenesis of type 2 diabetes, although its exact relationship to the insulin resistance is unclear. To determine whether insulin signaling has a functional role in the beta cell we have used the Cre-loxP system to specifically inactivate the insulin receptor gene in the beta cells. The resultant mice exhibit a selective loss of insulin secretion in response to glucose and a progressive impairment of glucose tolerance. These data indicate an important functional role for the insulin receptor in glucose sensing by the pancreatic beta cell and suggest that defects in insulin signaling at the level of the beta cell may contribute to the observed | [
-0.0365544,
-0.025027303,
0.002195406,
-0.013954539,
-0.009846063,
0.0016469602,
-0.023015253,
0.020574832,
-0.01932866,
-0.015745912,
0.017121894,
-0.0026984185,
-0.0022538202,
0.0042837188,
-0.0008940641,
-0.0056077773,
0.038086154,
-0.004728317,
0.006571614,
0.0016875257,
-0.029025441,
0.005682418,
0.0029839997,
-0.0075289607,
-0.00036407553,
-0.009599425,
-0.004692619,
-0.051456552,
-0.014240121,
-0.004812693,
0.012396823,
0.010404245,
-0.018043544,
0.021184936,
0.0021515952,
-0.015252636,
-0.0020088046,
-0.0014060009,
0.010144625,
-0.019510392,
0.0217561,
0.0097811585,
-0.0052864985,
0.0021337464,
0.0023122346,
0.006006942,
0.011786717,
-0.0023528002,
-0.016446885,
0.0064807474,
-0.0053254412,
0.015135807,
-0.019406544,
-0.025014322,
-0.004205833,
-0.0031349033,
0.00048110707,
0.015914666,
0.013013419,
-0.01436993,
0.0011934376,
-0.0021402368,
-0.0138636725,
0.0037709707,
0.0059063397,
0.013604052,
0.019250773,
0.008820566,
0.009794139,
0.017757962,
0.02912929,
0.01289659,
-0.0054877037,
0.002331706,
0.021288784,
-0.00049571064,
-0.009333314,
-0.006879912,
0.0015901683,
0.01571995,
0.03206299,
-0.015745912,
-0.013604052,
0.04810746,
0.011617965,
-0.012331918,
-0.007457565,
0.015421388,
-0.030712966,
-0.00012828846,
-0.010813145,
0.012396823,
0.011092235,
0.026325399,
-0.0067241406,
0.012682404,
-0.000742349,
0.04060446,
0.010968916,
-0.006169204,
-0.007626318,
0.02553356,
-0.020315213,
-0.020509927,
-0.014227139,
0.010962426,
-0.014707435,
-0.0028460769,
0.024819607,
-0.0054098177,
-0.008716719,
0.04553723,
-0.019004134,
-0.025884047,
0.012117732,
0.0020055594,
0.0013240585,
0.005396837,
-0.002229481,
-0.008788114,
0.026325399,
0.0058738873,
0.024702778,
-0.021730138,
0.01087805,
0.018056525,
-0.00409874,
-0.009599425,
-0.0059420373,
0.0015414897,
0.014097329,
0.0015715082,
0.037385184,
-0.011488155,
0.0012907948,
0.016174285,
-0.022106586,
0.004488169,
-0.012669424,
-0.033101466,
-0.014473777,
0.03008988,
-0.02526096,
0.009158072,
0.013240586,
0.015122826,
0.027441762,
-0.011215555,
-0.009229467,
0.012312447,
-0.018653648,
-0.007853485,
-0.0049782004,
-0.014356948,
0.042006407,
0.015343502,
-0.002075332,
0.021392632,
0.004248021,
-0.03489284,
0.014603587,
0.00544227,
-0.007626318,
0.022534957,
0.043330465,
0.014759359,
0.0029288305,
-0.0032095439,
0.028973516,
0.01464253,
0.0018027317,
0.012390332,
-0.0026724564,
0.031751443,
-0.0016331678,
0.016317075,
0.007840504,
0.0055396273,
-0.01597957,
-0.008878981,
-0.04016311,
0.03385436,
-0.0049100504,
0.025416732,
-0.011669889,
0.0139805,
0.030115843,
-0.008346762,
-0.0016145076,
-0.018303163,
0.016044475,
0.0015560933,
-0.0008924414,
-0.021976776,
-0.6409482,
-0.015966589,
0.02431335,
0.0014222271,
-0.013591072,
0.043590084,
0.01504494,
-0.021782061,
-0.010826126,
0.007204436,
0.005575325,
-0.0023008762,
0.0058284537,
-0.030479308,
-0.021197919,
-0.02163927,
-0.005614268,
-0.019497411,
0.017550267,
-0.011222046,
-0.02017242,
0.0016502053,
-0.013681939,
0.009956401,
0.0038391207,
0.0062503354,
0.015343502,
-0.007243379,
-0.0076133367,
0.039124634,
-0.009190524,
0.019354621,
0.004484924,
-0.002815247,
0.044265095,
0.014590606,
-0.00544227,
0.01962722,
0.022288319,
0.053845048,
0.009333314,
0.018562783,
0.02431335,
0.013448281,
-0.015927646,
0.015953608,
-0.0060913186,
0.0074510747,
0.012565576,
-0.00980712,
0.017498342,
0.008126085,
-0.047873802,
0.010099192,
0.018484896,
-0.020237327,
0.021782061,
-0.0217561,
0.02108109,
-0.005396837,
-0.00048029574,
0.035230342,
-0.019107983,
-0.023391701,
-0.0013597562,
0.004523867,
-0.012565576,
-0.008314309,
0.0069058742,
0.014123292,
0.030011995,
0.0083792135,
0.0016201868,
0.04662763,
0.014616569,
0.00335558,
0.015681008,
0.007146022,
0.00012321776,
0.016239189,
-0.0023998562,
0.009294372,
-0.015369464,
-0.008807586,
0.013681939,
0.018978173,
0.0028574353,
0.0108391065,
-0.0062795426,
0.00315762,
0.02471576,
-0.015590141,
-0.007834014,
-0.026312418,
-0.009904478,
0.030946624,
-0.008534986,
0.018108448,
0.01934164,
-0.028532164,
-0.019964727,
0.0038650827,
0.0013946425,
-0.025429713,
0.021574367,
-0.000039804916,
-0.021730138,
-0.0005334366,
0.046705518,
-0.03707364,
0.0059939614,
-0.0127018755,
-0.001625866,
-0.00046041864,
0.026221553,
-0.017706038,
0.0012275126,
-0.0026675886,
0.013850691,
-0.026442228,
0.004764015,
-0.024092674,
0.01613534,
-0.014253101,
-0.01974405,
0.0058511705,
0.013461262,
-0.0059323017,
-0.0019017116,
-0.008165028,
-0.014434835,
-0.019276734,
-0.0063217306,
-0.004900315,
-0.0063736546,
-0.0044492264,
0.017511323,
-0.007243379,
0.007574394,
-0.043953553,
-0.030453347,
-0.004205833,
-0.012312447,
0.011040312,
-0.009560482,
0.0011390798,
-0.009093167,
-0.010014815,
0.030635081,
0.002370649,
-0.0027438519,
-0.013798767,
-0.00064255786,
0.021236861,
0.03195914,
-0.005182651,
0.013357414,
-0.004634205,
-0.0030878473,
-0.0031478843,
0.003761235,
0.0066462546,
-0.0101381345,
-0.01342232,
-0.013383376,
-0.039643873,
0.017667096,
0.027441762,
-0.03408802,
-0.036736134,
-0.015395426,
0.004809448,
-0.009242448,
0.0051729153,
0.00046041864,
0.022651786,
-0.0025815896,
-0.014876188,
-0.0036054633,
-0.007944351,
0.0046114884,
-0.008444118,
-0.014019444,
0.014629549,
0.02822062,
-0.006260071,
0.028636012,
0.020315213,
-0.01262399,
0.015836779,
-0.037411146,
0.031128358,
-0.018523838,
0.010631411,
-0.0020607284,
-0.017264685,
0.021782061,
0.01141676,
-0.016187266,
0.026260495,
0.011806189,
-0.024430178,
0.015797837,
-0.048704587,
0.028402355,
-0.032763958,
0.014330987,
-0.013902615,
0.03398417,
-0.015356483,
-0.009281391,
0.018212296,
0.008911434,
-0.013902615,
0.0011001369,
0.01786181,
0.0035567847,
-0.0062308637,
-0.006866931,
-0.027467724,
-0.019770011,
0.003413994,
0.013208133,
0.00015191788,
-0.0116763795,
0.014681473,
0.015836779,
0.00035515113,
0.0012137203,
-0.028817745,
-0.017108914,
0.0019065795,
-0.0010117041,
0.012429276,
-0.023287853,
0.014551663,
-0.0009865535,
-0.0058381897,
0.02188591,
0.0051794057,
0.030998548,
0.014343968,
0.023274872,
0.020094536,
-0.020743584,
-0.015460331,
0.015434369,
0.030738927,
-0.013798767,
0.033776473,
0.0011772114,
0.023391701,
-0.019043077,
0.0029612829,
0.0084571,
0.005750568,
0.01652477,
-0.00899581,
0.053118113,
0.019095002,
0.011981432,
-0.0058381897,
0.0083272895,
-0.0050788033,
0.0028330958,
0.00967082,
0.016200246,
-0.004108476,
-0.0023690264,
0.009067205,
-0.037411146,
-0.00062714296,
0.00061416195,
-0.002464761,
0.009521538,
0.0174594,
0.012779761,
-0.012279994,
0.022742653,
-0.020899355,
-0.0008737813,
-0.038631357,
0.033387046,
0.0049230317,
-0.00349188,
-0.030453347,
-0.017770942,
-0.021431575,
0.010657374,
-0.0000137542465,
0.011059783,
0.023339778,
0.019640202,
-0.0060945638,
-0.013474243,
0.00070827396,
0.016901217,
-0.006522936,
0.012993948,
0.0066527454,
0.0020120498,
0.017134875,
-0.009054224,
-0.0035924825,
0.027753307,
0.026572037,
0.006607312,
-0.008093633,
0.0075938655,
-0.0010676845,
0.014720416,
-0.009962891,
0.014668492,
-0.020860413,
0.011624455,
0.00872321,
0.009820101,
0.0092164865,
0.031569712,
0.011773736,
-0.04821131,
-0.027078295,
0.003131658,
0.0015009242,
0.020743584,
0.02912929,
-0.005818718,
0.014305025,
-0.015745912,
0.010287416,
-0.0174594,
-0.029181212,
0.013052362,
-0.0075289607,
0.002579967,
0.014434835,
0.011306422,
0.0024923456,
0.004342133,
0.006866931,
-0.009359277,
-0.053221963,
0.017848829,
-0.010495111,
-0.017537285,
-0.0036963301,
0.038475584,
0.015797837,
0.02432633,
-0.020964261,
-0.004429755,
0.0071525127,
-0.002532911,
-0.0056207585,
0.010735259,
0.0087037375,
-0.0037904421,
0.004147419,
-0.0101381345,
-0.029622566,
0.011533588,
0.019640202,
-0.0039040255,
0.0147853205,
0.017082952,
0.010274434,
0.023028234,
0.0058738873,
-0.032997616,
-0.017939696,
-0.005036615,
0.034321673,
-0.0046569216,
0.0012591537,
0.018160371,
-0.019692127,
-0.007710694,
-0.0052215937,
0.009248938,
0.005426044,
0.028324468,
-0.011910036,
0.005520156,
0.008560947,
-0.016485827,
-0.01491513,
0.012851156,
-0.0085155135,
-0.0042350404,
-0.00020566718,
0.009566972,
-0.03278992,
-0.02217149,
-0.0011974941,
0.030972585,
-0.033283196,
0.0031949403,
0.00994342,
0.018082486,
0.0063249758,
0.0052183485,
-0.014343968,
0.016602656,
0.033387046,
-0.014318006,
-0.031595673,
0.004504395,
-0.03375051,
0.026520114,
0.019821936,
0.005387101,
-0.033776473,
-0.0076392987,
0.00050747464,
0.002888265,
-0.023028234,
0.00068109506,
0.0013451526,
0.0041896068,
-0.017550267,
0.004780241,
0.027467724,
0.018562783,
-0.023690263,
-0.008035218,
-0.005224839,
-0.022327263,
-0.018225277,
-0.016239189,
-0.006782555,
-0.00913211,
-0.006123771,
-0.0009102903,
-0.027857155,
0.00858691,
0.0044265096,
0.0144607965,
-0.0083272895,
0.015265617,
0.031855293,
0.0006380956,
0.013110776,
0.004176626,
-0.008632342,
-0.021924851,
-0.03608709,
0.013396357,
-0.0050268793,
-0.018952211,
0.0031754689,
0.0031965629,
-0.020055594,
-0.008372723,
-0.01612236,
-0.009631877,
0.03855347,
-0.006503464,
-0.017251704,
-0.0314399,
0.0028476994,
-0.009184034,
0.0057603037,
0.012708366,
-0.014824264,
-0.027519649,
0.002425818,
0.008392194,
-0.028480241,
0.031284127,
-0.035645735,
-0.017342571,
0.017407475,
0.006691688,
-0.0015487915,
0.00036407553,
0.009255429,
-0.023300834,
-0.012085279,
-0.027909078,
-0.029492756,
-0.0051696696,
-0.014694454,
0.029804299,
0.058725893,
0.013208133,
0.01584976,
0.017667096,
0.0052215937,
-0.00013001249,
0.0383977,
0.005559099,
-0.00174594,
-0.023002272,
0.01829018,
0.011935999,
-0.015486293,
0.020042611,
-0.018471915,
0.026364343,
-0.0074770367,
-0.0040630423,
-0.00724987,
-0.005104765,
-0.024598932,
-0.022664767,
-0.0060783373,
-0.015681008,
-0.010910503,
-0.03266011,
-0.01141676,
0.0031689785,
-0.0121891275,
-0.007412132,
-0.00014887546,
0.008950376,
-0.020458004,
0.05389697,
0.009839573,
0.00015151221,
-0.02188591,
-0.050573844,
0.0011439477,
0.0004555508,
0.0039007803,
-0.008840038,
0.0060880734,
-0.015031959,
-0.008658305,
-0.003248487,
0.0042642476,
-0.014434835,
0.009067205,
0.0063217306,
-0.00952803,
-0.011397288,
-0.008943886,
-0.0325303,
-0.035931315,
-0.007509489,
0.010767711,
-0.02996007,
0.008963358,
-0.022924386,
-0.020743584,
-0.0060231686,
-0.0047737504,
0.027182143,
0.008917924,
0.030557195,
0.023664301,
0.00699025,
-0.020237327,
-0.006286033,
0.013798767,
0.005130727,
0.025819141,
0.009657839,
0.004290209,
-0.0138117485,
-0.004510886,
0.009300862,
-0.012935533,
-0.018043544,
0.011715322,
-0.008969848,
0.0007841315,
-0.0120009035,
-0.0042577568,
-0.021743119,
-0.002592948,
-0.024378255,
0.022327263,
-0.013091304,
-0.006529426,
-0.021561384,
0.019082021,
0.006879912,
0.011319403,
0.009333314,
-0.029492756,
0.006892893,
-0.004783486,
-0.007963823,
-0.000029283234,
0.008541476,
0.013383376,
-0.0039591948,
0.00065391615,
0.0060231686,
0.00007819004,
0.001960126,
-0.0035924825,
-0.017082952,
0.03494476,
0.022586882,
-0.02954468,
0.020107517,
-0.012442256,
-0.014629549,
0.0036281801,
-0.0032030535,
-0.017887771,
-0.03291973,
-0.002122388,
0.02108109,
0.031076433,
-0.024209503,
0.010112173,
-0.018497877,
-0.004510886,
-0.031128358,
-0.012286484,
-0.012020375,
-0.025468657,
0.0070940983,
-0.037437107,
-0.0027227576,
0.010865069,
0.016719485,
0.012260523,
0.01102084,
0.02471576,
-0.027078295,
0.013630015,
-0.009579953,
-0.0018384294,
-0.007944351,
0.0024371764,
-0.022275338,
-0.019289715,
0.0016234322,
-0.017706038,
-0.041045815,
-0.012396823,
-0.024274407,
0.0028736615,
0.025481638,
0.016018512,
-0.004874353,
0.0070746266,
0.026610982,
-0.0073082843,
-0.01960126,
-0.0012518519,
-0.03925444,
0.0124617275,
0.01088454,
0.0002932887,
-0.026636943,
-0.008405176,
-0.01801758,
0.006944817,
0.021016184,
-0.013526167,
-0.013091304,
0.012922552,
-0.0072368886,
-0.000011725971,
-0.021470519,
-0.0072758314,
-0.027311953,
0.0064418046,
0.016966123,
-0.006996741,
-0.045848772,
-0.011598493,
-0.013201643,
0.015408407,
-0.0004944937,
-0.016732465,
-0.012552595,
-0.024118636,
-0.015122826,
-0.004458962,
-0.031232204,
0.0435122,
0.01154657,
0.0053416677,
-0.030349499,
0.011754265,
-0.011189593,
-0.02106811,
-0.011923018,
0.032763958,
-0.012364371,
0.013655976,
-0.027597534,
0.02309314,
-0.009820101,
0.010248473,
-0.012779761,
-0.0067630834,
0.018121429,
-0.007626318,
0.03195914,
0.010410735,
-0.026130686,
-0.03237453,
0.04060446,
-0.011137669,
0.0014709057,
0.01652477,
-0.0319851,
0.037904423,
-0.0055298917,
0.010865069,
0.0097292345,
0.0077301655,
0.025494618,
-0.023599397,
-0.008165028,
0.013383376,
-0.0068864026,
-0.0015617725,
-0.004176626,
-0.0019033342,
0.0062795426,
0.0030521497,
0.0070032314,
-0.03408802,
-0.0049652196,
-0.0009735725,
0.0073926602,
0.0076782415,
0.008236423,
-0.011397288,
0.011066274,
-0.0031852047,
-0.017706038,
-0.019666163,
0.009112638,
0.018445954,
-0.0028915103,
-0.0012559085,
-0.014253101,
-0.012883609,
0.014097329,
-0.04029292,
0.004196097,
-0.009696782,
0.0024063466,
-0.039280403,
0.021184936,
0.008573928,
-0.013915596,
-0.0031138093,
0.010715787,
-0.0062308637,
0.0037093111,
0.009872025,
0.0124617275,
0.004390812,
-0.0024079692,
0.0004445981,
-0.009034753,
0.013448281,
-0.007373189,
-0.033490892,
-0.032452416,
-0.0035827467,
0.16885641,
-0.032192796,
0.017900752,
0.0070486646,
0.002807134,
0.0040500616,
-0.016343037,
0.002909359,
-0.0061724493,
-0.0059290566,
0.011137669,
-0.0018952211,
-0.013902615,
-0.0004908428,
0.0009816856,
0.018121429,
-0.014954073,
-0.00966433,
-0.016563714,
0.0004239097,
-0.001074175,
-0.006146488,
0.0085934,
0.0057116253,
0.0510152,
0.0061562234,
-0.018432973,
0.0053806105,
0.028064849,
0.031907216,
-0.03842366,
0.021730138,
-0.0061042993,
0.035879392,
0.0145127205,
0.006123771,
-0.0061821854,
-0.009489086,
0.025624428,
0.0020006914,
-0.0081909895,
0.012195618,
-0.0054974393,
0.002182425,
0.0043518688,
0.011585512,
0.014694454,
-0.008346762,
-0.0008940641,
0.0008372723,
-0.028480241,
-0.014356948,
0.015317541,
0.023833055,
0.0134872245,
-0.0073666982,
0.009190524,
0.0020526154,
0.002203519,
-0.004527112,
-0.025183074,
-0.0072888127,
-0.009794139,
0.051119044,
-0.036969792,
0.03694383,
-0.024663836,
-0.0003742169,
0.007178474,
-0.021314748,
0.0057440777,
-0.016226208,
-0.0043031904,
-0.0023949882,
-0.012260523,
0.0017151101,
0.026390305,
0.0023820074,
0.024261426,
-0.0060231686,
-0.004387567,
0.030375462,
-0.037021715,
-0.020704642,
-0.00017970525,
-0.03346493,
0.032166835,
-0.011286951,
-0.0059972066,
-0.001698884,
-0.005802492,
-0.007178474,
-0.020003669,
-0.024001807,
-0.008956866,
-0.025858086,
-0.0063509378,
0.017368533,
0.0011488155,
-0.016096398,
-0.004634205,
0.097824566,
-0.015797837,
0.008541476,
-0.022729672,
-0.0180046,
-0.013130248,
0.013019909,
0.007243379,
0.0059972066,
0.008041709,
-0.023209969,
-0.007749637,
-0.017641133,
-0.0071525127,
0.020458004,
0.017407475,
-0.003923497,
-0.005536382,
-0.013078324,
-0.008671286,
-0.005516911,
-0.0015171504,
-0.0013256812,
-0.0070746266,
0.018978173,
-0.009885006,
-0.002276537,
-0.00792488,
-0.014538682,
-0.0067890454,
-0.016641598,
0.004650431,
0.011455703,
0.002721135,
-0.010683335,
0.011196083,
-0.003761235,
-0.0041571544,
0.02295035,
-0.010709297,
-0.011001369,
0.012448747,
0.011877584,
-0.0012924174,
-0.024248445,
0.028480241,
0.009625386,
-0.005935547,
0.009197014,
-0.02483259,
-0.041565053,
-0.0038456114,
-0.0012242674,
0.031050472,
-0.015732931,
-0.0003087036,
-0.039280403,
0.003624935,
-0.002982377,
-0.0010465904,
0.024092674,
0.004458962,
0.013071833,
-0.01557716,
0.005841435,
-0.16137937,
0.013240586,
0.013850691,
-0.020522907,
0.023846036,
0.0035470491,
-0.0020266534,
0.0026383814,
0.012552595,
0.036839984,
0.02633838,
-0.02754561,
-0.02886967,
0.0260528,
0.0074056415,
-0.0040078736,
-0.0049327672,
0.033620704,
0.02030223,
-0.009573462,
0.018186335,
-0.025442693,
0.018303163,
-0.016732465,
-0.008041709,
0.028116774,
0.0013191907,
0.0013824729,
0.0014473777,
-0.0138636725,
-0.013305491,
0.0040662875,
0.048055537,
-0.0074900175,
0.040526576,
-0.019185869,
-0.0076068463,
-0.022937367,
0.0044427356,
0.012877119,
0.051456552,
0.03707364,
-0.00570838,
0.00671765,
-0.01771902,
0.01987386,
0.018316144,
0.04044869,
0.014564645,
0.016719485,
0.022444092,
0.0018124675,
0.02218447,
0.025884047,
0.011903546,
0.007970314,
-0.01732959,
0.00926841,
-0.0027795495,
0.0058901133,
-0.014447816,
-0.017926715,
0.02970045,
-0.00752247,
-0.000058465055,
-0.012604519,
0.010293907,
-0.006769574,
-0.019302698,
0.011066274,
-0.025559522,
-0.01449974,
0.012961495,
-0.01289659,
0.012552595,
0.00993693,
-0.0077042035,
-0.008152047,
0.002310612,
-0.004137683,
-0.012318937,
-0.0011731548,
-0.03206299,
-0.024352293,
-0.0060361493,
0.006678707,
0.021950815,
0.024378255,
0.00002674789,
0.012604519,
0.0180046,
-0.04094197,
0.010410735,
-0.025222018,
0.0009443653,
0.022054661,
0.006970779,
0.0017572984,
0.022145528,
0.0016469602,
0.012292976,
-0.010793674,
-0.00009619099,
-0.0009265165,
0.015135807,
-0.004851636,
-0.04525165,
-0.017225742,
0.03663229,
-0.008288347,
-0.008145557,
-0.0062113926,
0.007645789,
0.009975873,
-0.005951773,
0.010300397,
0.017524304,
-0.0065488974,
0.0365544,
-0.03637267,
0.06770872,
0.00002248851,
0.012942024,
0.029103326,
0.0064677666,
-0.02041906,
-0.13043275,
-0.056389317,
0.015758893,
0.024118636,
-0.003345844,
0.011948979,
0.004384321,
0.026585018,
-0.027078295,
0.01989982,
-0.04338239,
-0.0053514033,
-0.011364836,
-0.011189593,
0.0007313963,
0.0056921537,
0.01209826,
-0.005198877,
-0.022145528,
0.037904423,
-0.007736656,
-0.032322608,
0.0010912125,
-0.0032906749,
0.007223908,
0.020237327,
-0.01008621,
0.012669424,
-0.0009500445,
0.022236396,
0.024456142,
0.0030132069,
0.018316144,
0.0055720797,
-0.014811283,
-0.0047705052,
-0.009235958,
-0.020587813,
0.046419937,
-0.008405176,
0.0070227026,
0.009703272,
0.0101381345,
0.0014076235,
-0.026896562,
0.012370861,
-0.0018757497,
-0.0090023,
0.01934164,
-0.025273941,
-0.01141027,
-0.010579487,
-0.029466793,
-0.02404075,
0.03603516,
-0.0123773515,
-0.0010563261,
0.017926715,
-0.0023154798,
-0.0010595714,
0.032166835,
0.0059323017,
-0.009956401,
-0.00015830694,
0.021730138,
-0.014759359,
-0.007334246,
-0.04436894,
0.03304954,
-0.019549334,
0.018835383,
0.006380145,
-0.0016120737,
-0.020470984,
-0.031310093,
0.008969848,
-0.010988388,
0.006685198,
-0.0016266773,
-0.02295035,
0.003329618,
-0.01853682,
0.02406671,
-0.023054196,
0.019964727,
-0.0065359166,
0.024676817,
0.003076489,
0.0064580305,
0.0012867383,
-0.0182772,
0.026247514,
0.011656907,
0.008184499,
-0.008606381,
0.0134872245,
-0.0008413289,
-0.022093605,
0.015265617,
0.0039527044,
-0.011656907,
0.0020899356,
-0.030868739,
0.007937861,
-0.004621224,
-0.0019422771,
0.0041182116,
-0.013318472,
-0.014694454,
-0.011923018,
-0.0026351362,
0.0009589689,
0.0023592906,
0.018394029,
0.017018046,
-0.01705699,
-0.016940162,
-0.04029292,
0.010858579,
-0.01813441,
-0.0046082432,
0.020055594,
-0.0005813039,
0.009197014,
0.026740791,
0.00671765,
-0.019847898,
-0.012825195,
-0.022794576,
0.01813441,
-0.009080186,
-0.041565053,
-0.0013662467,
-0.031673558,
-0.01948443,
0.008385704,
-0.012883609,
-0.009106148,
0.0077431463,
0.038215965,
0.03777461,
0.023145063,
0.010482131,
-0.043849703,
-0.004445981,
-0.010144625,
-0.00030322725,
-0.004497905,
-0.04982095,
0.008100123,
-0.007016212,
0.0043453784,
0.006821498,
0.018562783,
-0.014564645,
-0.024611913,
0.014889169,
-0.007178474,
0.012176147,
-0.014032424,
-0.037644804,
-0.013604052,
0.022729672,
0.018718554,
0.012234561,
-0.009222977,
0.00005922566,
-0.028194658,
-0.047873802,
0.0034626727,
0.008762152,
0.0004973333,
-0.010644392,
0.01717382,
0.01719978,
0.012468218,
0.017264685,
-0.00036995753,
-0.022483034,
-0.009774667,
0.009547501,
0.036969792,
0.023391701,
0.0027097766,
-0.035282265,
0.0033215047,
0.026039818,
0.005133972,
0.0019146926,
0.008820566,
0.013143228,
-0.0073017934,
0.016446885,
0.026182609,
-0.002828228,
0.033646666,
0.0053611393,
0.03548996,
-0.0043486236,
0.008074161,
-0.025299903,
0.008087142,
-0.018432973,
-0.0005967188,
-0.0053611393,
-0.032971654,
-0.010384773,
-0.001320002,
-0.019679146,
-0.037670765,
-0.013409338,
0.008158538,
-0.009748706,
-0.009910968,
0.029466793,
0.00025779387,
-0.016888237,
0.0073537175,
-0.00900879,
0.0057603037,
-0.009904478,
0.016304094,
0.010534055,
0.0002888265,
-0.0054617417,
0.0066527454,
-0.0072368886,
0.0031024509,
0.026922524,
-0.045147803,
-0.0012526632,
-0.009372258,
0.022534957,
-0.022885444,
-0.03883905,
-0.020756565,
-0.010891031,
-0.0072303982,
0.01449974,
-0.0008084708,
-0.009995344,
0.0789762,
0.012267013,
-0.0055980417,
-0.017628152,
-0.018822402,
0.021535423,
-0.008827057,
0.017031027,
-0.02471576,
-0.017290648,
0.008775134,
-0.011299931,
0.016810352,
-0.036164973,
-0.02835043,
0.021859948,
0.0078664655,
-0.012987457,
-0.00046650346,
-0.015265617,
-0.00806118,
-0.03102451,
0.0030196973,
-0.0095410105,
-0.032192796,
-0.0044686976,
0.022599863,
0.020717623,
0.0072174175,
-0.042967,
0.0023771394,
-0.016654579,
-0.04231795,
0.007457565,
0.023041215,
0.0002644872,
-0.012247542,
-0.010852088,
0.02218447,
0.026429247,
0.0062081474,
0.008982829,
-0.041461207,
-0.031128358,
-0.014577625,
-0.0017362043,
-0.007749637,
-0.009515048,
-0.012455237
] |
OBJECTIVES To determine the extent to which type of hospital admission (emergency compared with elective) and surgical procedure varied by socioeconomic circumstances, age, sex, and year of admission for colorectal, breast, and lung cancer. DESIGN Repeated cross sectional study with data from individual patients, 1 April 1999 to 31 March 2006. SETTING Hospital episode statistics (HES) dataset. PARTICIPANTS 564 821 patients aged 50 and over admitted with a diagnosis of colorectal, breast, or lung cancer. MAIN OUTCOME MEASURES Proportion of patients admitted as emergencies, and the proportion receiving the recommended | [
0.0032394063,
0.0048616207,
0.01592415,
-0.05630373,
-0.018401837,
0.015415221,
0.0042656367,
0.016834868,
-0.03433938,
-0.0029748967,
-0.014129504,
0.01392861,
-0.0033013483,
0.022928635,
-0.03383045,
-0.008283505,
0.03096437,
-0.02175006,
-0.012662982,
-0.004717647,
-0.022848276,
0.012696464,
0.00035805066,
0.014276825,
-0.008946453,
0.0030753433,
0.023196492,
-0.020651843,
0.011651818,
-0.0106674405,
0.009803599,
-0.006140642,
-0.028607221,
-0.0075335028,
-0.022875063,
0.010566994,
0.00056292006,
0.013165215,
0.022741133,
-0.022580419,
0.020745592,
-0.011953158,
0.0037366175,
-0.004178583,
-0.00017452615,
0.011243335,
0.005795775,
-0.021227738,
-0.032250088,
0.0027706549,
-0.0033147412,
0.019392911,
-0.015977724,
-0.0071183234,
-0.004553584,
-0.0043493425,
0.006214303,
0.01920541,
0.0029598295,
-0.008825917,
0.0023755645,
-0.0116853,
-0.027589362,
0.008343773,
-0.033991165,
0.0013526822,
-0.026209895,
0.004121663,
0.0118192285,
0.023812566,
0.038946535,
0.032544732,
-0.0075401994,
-0.0011258401,
0.014330396,
-0.0015711539,
-0.0062645264,
-0.0015234418,
0.010767886,
0.017183082,
-0.010580386,
-0.025138462,
-0.017236654,
0.021482201,
0.022178633,
0.0016263996,
-0.0019135097,
0.030241154,
-0.018522372,
0.011551371,
0.015174149,
0.009910742,
0.022325953,
0.008437524,
-0.0066428753,
0.020290235,
-0.014986648,
0.021709882,
0.032491162,
-0.03270545,
-0.018723266,
0.008658506,
-0.024830425,
-0.00167746,
-0.012709856,
-0.0009375026,
-0.0036663048,
0.0040848325,
0.014879505,
-0.006117204,
0.0020005635,
0.03707153,
-0.004031261,
-0.015000042,
0.031259015,
-0.016741117,
-0.0008897904,
0.0049821567,
-0.022325953,
-0.01907148,
0.0066160895,
-0.0009483843,
0.036937602,
-0.024857212,
0.022553634,
-0.026062572,
-0.033026878,
-0.00096512545,
0.012234408,
-0.009247793,
-0.023317028,
-0.029812582,
0.02512507,
0.033991165,
-0.007640646,
0.020303627,
-0.015562543,
0.0034687596,
-0.044571552,
-0.025339356,
-0.004238851,
0.015843794,
0.0228081,
-0.027642934,
-0.028821507,
0.018267907,
0.040473327,
0.013359412,
0.0028359452,
0.0050256834,
0.02063845,
-0.008377255,
-0.006545777,
0.0129710175,
0.004004475,
-0.003145656,
0.017933086,
0.020799164,
-0.022620598,
-0.039589394,
-0.0182813,
-0.009488866,
0.0008671899,
0.009622795,
0.010500029,
0.026692038,
0.018080408,
0.0032377322,
0.0031573747,
0.00039864786,
-0.027227754,
0.013955396,
-0.00893306,
0.0007960401,
0.017183082,
0.024147388,
-0.017142905,
0.010674137,
-0.05571444,
-0.031044729,
-0.02670543,
0.026250072,
0.016406296,
0.013875038,
-0.017022368,
0.007854932,
0.031339373,
0.0009174132,
-0.011136191,
-0.011229942,
0.010104938,
0.029866153,
-0.015977724,
0.005367202,
-0.6432875,
-0.017611656,
-0.0012396798,
0.00012357037,
0.006964305,
0.018361658,
0.007191984,
0.0059732306,
-0.031446517,
0.018442014,
0.016513439,
0.0048783617,
0.036160816,
-0.002561391,
-0.009488866,
-0.015763436,
-0.007399574,
0.01270316,
0.01200673,
0.0030954327,
-0.012756731,
0.03841082,
-0.0066997954,
0.026973289,
0.00386385,
0.03591974,
0.016808081,
-0.007051359,
0.024964355,
-0.0044430927,
-0.008310291,
0.018053621,
0.008471006,
0.0053705503,
0.035303667,
-0.011718783,
-0.008799131,
0.027669718,
0.03136616,
0.022754528,
-0.0026132884,
-0.0034855006,
0.024522388,
0.012053604,
-0.019232197,
0.026638467,
-0.013091554,
0.013091554,
-0.0010463198,
0.0058326055,
0.0058459984,
0.01800005,
-0.016633974,
0.0016063103,
0.024750069,
0.0016682524,
0.023946494,
-0.029410796,
-0.00047754036,
-0.0047879596,
-0.0061707757,
0.012267891,
-0.02785722,
-0.022968814,
0.014959862,
0.027910791,
-0.018468801,
0.0060703293,
0.015843794,
0.0018900721,
0.019379517,
0.029839369,
-0.008718774,
0.004717647,
0.03900011,
0.0017912996,
-0.009107168,
0.017156297,
-0.035276882,
-0.00021072882,
-0.0013367783,
0.018080408,
-0.02165631,
-0.0038437606,
0.0052801487,
-0.012221016,
-0.013834859,
0.0026735566,
0.018910766,
0.013754502,
0.0065658665,
0.0154554,
-0.010412975,
0.006458723,
-0.008979935,
0.016031295,
-0.00087388634,
-0.0018231077,
0.0018532417,
-0.034392953,
-0.02397328,
-0.0014799148,
0.008062522,
0.016232187,
0.0039509037,
0.00015820356,
-0.014571468,
0.010935298,
0.026183108,
-0.026437573,
0.003205924,
0.00047837742,
0.01147771,
0.014183075,
0.00056668685,
-0.02938401,
-0.007975468,
0.0103527075,
-0.008725471,
-0.003924118,
0.03725903,
0.02378578,
0.00009840638,
-0.012127265,
0.023035778,
0.031767946,
-0.006321446,
0.010767886,
-0.0020122824,
-0.022968814,
0.0026099402,
-0.0160179,
0.007955379,
0.0007278201,
0.0031238925,
-0.0098638665,
0.008926364,
-0.018910766,
-0.0062812674,
-0.032785803,
-0.01841523,
-0.016165223,
0.020611664,
-0.004506709,
-0.008457612,
-0.011002262,
-0.023705423,
0.0024090467,
-0.0031925312,
-0.0010672462,
-0.028955437,
-0.030428655,
-0.0035725546,
0.0016263996,
-0.009267882,
-0.0010228823,
0.00030929214,
-0.010928602,
-0.014410754,
-0.0039509037,
0.0051294784,
0.019968806,
-0.005792427,
-0.016071472,
-0.013319233,
-0.017692013,
-0.020986665,
0.018870588,
-0.009636187,
-0.036482245,
-0.0005378084,
-0.009890652,
0.012328159,
0.018991124,
0.005062514,
-0.007352699,
-0.022165239,
-0.0064788125,
0.012348249,
-0.0024559218,
0.010660743,
0.00039802006,
-0.0031841605,
0.015334863,
0.020933094,
0.022580419,
0.0056852833,
-0.01786612,
-0.00016950381,
0.00049302593,
-0.0025965474,
0.006452027,
0.0006420219,
0.01818755,
0.0029631779,
-0.0053102826,
-0.003907377,
0.012602713,
0.015575936,
0.004151797,
0.023437565,
-0.011825926,
0.029973296,
0.0049051475,
0.011852711,
0.008812524,
0.020424163,
0.016500045,
0.008959847,
-0.010680833,
0.015093791,
-0.0016649042,
-0.018977731,
-0.0057455515,
-0.0092344005,
0.03956261,
-0.001722661,
-0.009696456,
-0.018227728,
0.003549117,
-0.007888415,
0.014477719,
0.016955404,
0.01351343,
-0.01883041,
0.0005223229,
0.023250064,
0.00047419214,
-0.009221007,
-0.009984403,
-0.0034520184,
0.024334889,
-0.0028074854,
0.01990184,
0.017758977,
0.017692013,
0.014062539,
-0.0035122863,
-0.010520118,
0.0021746713,
-0.012154051,
0.023665244,
0.025352748,
0.003924118,
-0.01536165,
-0.031741157,
0.022714349,
0.016607188,
-0.0020825951,
-0.008002254,
0.0033331565,
0.007098234,
-0.008089308,
0.011859408,
0.008042433,
-0.0046674237,
0.0034386255,
0.03238402,
0.043741193,
0.020169698,
0.022928635,
0.0032025757,
-0.00024881485,
0.0065692146,
-0.007834843,
-0.0049486742,
-0.0054442114,
0.012924143,
-0.006622786,
-0.0034202102,
-0.0042488957,
-0.02698668,
0.007158502,
-0.035759028,
0.006304705,
0.013861645,
0.014584862,
-0.0074531455,
0.011250031,
0.012575927,
-0.0070312694,
-0.026022393,
0.012147355,
0.030750085,
0.0025798061,
-0.01860273,
0.015334863,
0.015120577,
-0.0010689204,
0.02359828,
0.010654047,
0.01159155,
0.013875038,
0.004540191,
-0.0054341666,
-0.0010287417,
0.011825926,
-0.018442014,
0.003746662,
0.007299127,
0.00077260257,
-0.011886193,
-0.014357182,
-0.029625082,
0.03337509,
0.01189289,
-0.018776838,
-0.02578132,
-0.01402236,
-0.018843802,
-0.007593771,
-0.030535799,
-0.02327685,
0.00024881485,
0.009924134,
0.013982181,
-0.013727716,
-0.006381714,
0.013238876,
-0.0066730096,
0.002069202,
-0.03238402,
-0.00865181,
-0.015375042,
0.053705506,
0.01076119,
0.010305832,
0.019513447,
0.030482227,
-0.018294694,
-0.00036495636,
-0.009502258,
-0.00065081095,
0.012354945,
-0.014209861,
0.034473307,
0.028178649,
0.00599332,
0.021361666,
0.019633982,
0.009120561,
-0.0030016825,
-0.00052776374,
-0.01879023,
-0.021000057,
-0.020584878,
0.031392943,
0.02702686,
0.012616106,
-0.012522356,
0.032169733,
0.012334855,
0.016593795,
-0.008404041,
-0.04387512,
0.021508988,
-0.013178607,
0.033428665,
-0.012602713,
-0.003115522,
0.025741143,
-0.008477702,
0.01948666,
-0.009154043,
0.013031286,
-0.001797996,
0.000351982,
0.0016356072,
0.02142863,
-0.024455424,
0.0063114013,
0.02470989,
-0.00116853,
-0.015535757,
0.026397394,
-0.006234392,
-0.013587091,
-0.018428622,
0.0045904145,
0.0038270194,
-0.0034855006,
-0.013044679,
-0.019084875,
-0.0047946563,
-0.009629491,
-0.0061808205,
0.021093808,
0.0013091554,
-0.021254523,
-0.015254506,
-0.04122333,
-0.013151822,
-0.0055312654,
0.001273162,
-0.014317004,
-0.03275902,
-0.010633958,
0.023491137,
0.0108415475,
-0.011323692,
0.023531314,
0.0017561432,
0.0108080655,
-0.0050859516,
0.003987734,
0.007379485,
0.0034386255,
-0.01795987,
-0.0068705548,
0.0016046361,
-0.020705415,
-0.012950929,
-0.011450924,
0.037285816,
0.021763453,
-0.017665228,
-0.00041392414,
0.01577683,
-0.007500021,
0.018575944,
-0.0026283555,
0.011424138,
-0.024267923,
-0.025178641,
0.0011291883,
-0.021575952,
-0.031259015,
-0.008129487,
-0.0056350604,
-0.018937552,
-0.02823222,
-0.004834835,
0.002275118,
-0.017330404,
0.033616163,
-0.025138462,
0.018750051,
-0.012723249,
0.014209861,
0.011584854,
-0.025178641,
0.02207149,
0.038866177,
-0.008183058,
-0.0007776249,
0.00018655883,
0.009261186,
0.000032043547,
-0.039026894,
0.008116093,
-0.01883041,
-0.021026844,
-0.03508938,
-0.01675451,
0.000160924,
0.021321487,
-0.008136183,
-0.02308935,
-0.017196476,
-0.010861637,
-0.014169682,
0.010198689,
-0.011631728,
-0.024067031,
-0.011504496,
0.0026635118,
-0.0024056986,
-0.018495586,
0.030669726,
-0.025700964,
-0.013058072,
0.0027539139,
-0.020986665,
0.0055312654,
0.01596433,
0.016125044,
0.012522356,
0.0027187576,
-0.0067801527,
-0.028660793,
-0.0026250072,
0.004630593,
0.044598337,
0.048803706,
0.042321544,
0.00401452,
0.022138454,
0.015442007,
0.0024190915,
0.025232213,
-0.005092648,
0.014584862,
0.016580403,
0.037875105,
0.01707594,
-0.000486748,
-0.0018164113,
0.013647359,
0.0053136307,
-0.012053604,
0.0019654073,
-0.019272374,
-0.026183108,
-0.032410804,
-0.034714382,
0.0036629564,
0.0069241263,
0.01200673,
-0.045964412,
-0.0039442074,
-0.022848276,
0.0027974409,
-0.00955583,
-0.00015841282,
0.012783517,
0.0014003945,
0.0050156387,
-0.015977724,
-0.012267891,
0.0038236713,
-0.020959878,
-0.024843818,
-0.0020407422,
-0.00010536441,
-0.002306926,
0.02540632,
0.012395123,
-0.019017909,
0.0006650409,
0.0013518452,
-0.033669736,
0.0004065999,
-0.0058794804,
-0.026759002,
-0.013165215,
-0.008169665,
0.004419655,
-0.018897373,
-0.010319225,
0.017504513,
-0.00056250155,
0.029223295,
-0.0073326095,
0.001871657,
-0.016165223,
-0.022165239,
0.012582624,
-0.026397394,
0.027187575,
0.0035892955,
-0.013084858,
-0.0010622239,
0.004928585,
-0.0025546944,
0.013861645,
0.02359828,
0.021723274,
-0.00043485052,
0.01758487,
0.006472116,
0.027214361,
-0.011544675,
-0.025567034,
0.014169682,
-0.0004065999,
0.006515643,
-0.010446457,
-0.011544675,
-0.023156313,
0.0013920239,
0.003371661,
0.000043788485,
0.022406312,
-0.032250088,
0.0015351605,
0.019540232,
-0.04497334,
0.02359828,
0.00094587315,
-0.018589336,
0.003431929,
-0.016647367,
-0.01712951,
0.0050859516,
-0.0064855088,
0.0180938,
-0.023303635,
-0.0043526907,
0.015897365,
-0.005199791,
-0.0030770174,
-0.01332593,
-0.015281292,
0.03350902,
0.0023621717,
-0.019151838,
0.016995583,
0.004647334,
0.009328151,
-0.0004628919,
-0.012542445,
0.0075870743,
-0.03594653,
-0.006308053,
0.023169708,
0.01633933,
-0.016459867,
-0.008136183,
-0.015281292,
-0.009020114,
-0.012857178,
-0.009522348,
-0.006619438,
-0.008437524,
-0.0137411095,
-0.015468793,
0.012120569,
0.02175006,
0.011049137,
0.014866113,
-0.008069219,
0.030535799,
-0.01573665,
0.0056116227,
-0.005075907,
0.010620565,
-0.027241146,
0.017142905,
-0.018870588,
-0.013218787,
0.002318645,
0.00035240053,
-0.022205418,
-0.03192866,
-0.0028577088,
-0.010031277,
0.012582624,
-0.00035763212,
0.010285743,
0.015562543,
0.0148928985,
-0.012555839,
-0.019192018,
0.025459891,
-0.026009,
0.015562543,
0.015107185,
-0.018388443,
0.022125062,
-0.016299153,
0.012883964,
-0.010325922,
-0.016459867,
-0.008725471,
-0.0035625098,
0.029009009,
-0.021817025,
0.009033507,
-0.032196518,
0.02027684,
-0.010386189,
0.024964355,
0.00012566302,
-0.010948691,
0.027254539,
-0.014464325,
0.008042433,
0.01494647,
-0.011712085,
-0.0027288022,
0.0010320899,
0.0035859474,
-0.0047109504,
-0.0024626183,
-0.008625024,
0.041625116,
0.026317038,
-0.0077678785,
-0.015348257,
-0.0037131798,
-0.032491162,
-0.011886193,
-0.005122782,
0.02637061,
0.011397352,
-0.0002035092,
0.00039488112,
0.013546912,
-0.0029882896,
-0.007299127,
-0.025607213,
-0.030482227,
0.018241122,
-0.016741117,
0.0047980044,
0.009361633,
-0.03262509,
-0.005792427,
0.0017126163,
0.018361658,
-0.007627253,
0.021321487,
-0.034553666,
-0.00731252,
-0.016325938,
0.0042957705,
-0.011785747,
0.006971001,
-0.0261965,
-0.041009042,
-0.000023803777,
0.0029765707,
0.0017460985,
-0.008457612,
-0.001438062,
-0.000025634836,
0.020397378,
-0.011979944,
0.008196451,
-0.026035786,
-0.00422211,
-0.028205436,
0.005574792,
0.026062572,
0.020250056,
0.02207149,
0.0025965474,
0.014049145,
-0.022379527,
-0.009877259,
-0.004439744,
-0.022459883,
-0.009180829,
-0.01994202,
-0.008611631,
-0.00893306,
-0.010687529,
-0.00017567711,
0.0030652985,
-0.02438846,
-0.024857212,
-0.01260941,
0.025473284,
-0.03179473,
-0.031741157,
-0.0065725627,
0.008825917,
-0.021401845,
-0.008323683,
-0.04114297,
0.017665228,
-0.044812623,
0.0005403196,
-0.004871665,
-0.0017025716,
0.024442032,
0.004342646,
-0.024549175,
0.0038437606,
0.008464309,
0.20464343,
-0.008638416,
0.010071456,
0.015937544,
-0.00031703492,
0.00446653,
0.005470997,
0.01554915,
-0.017424155,
0.053276934,
-0.015723258,
-0.00844422,
-0.0013945351,
0.010767886,
0.015883973,
-0.017317012,
-0.030884014,
-0.016741117,
0.008551363,
-0.000033796132,
0.003893984,
0.007580378,
0.0014815889,
-0.020183092,
0.020651843,
-0.0018582641,
0.009924134,
-0.00236552,
0.033214375,
0.0018766792,
-0.014049145,
-0.014102718,
-0.010794672,
0.01177905,
-0.005792427,
-0.006937519,
0.0052098357,
-0.017571477,
0.0034068173,
0.0069308225,
-0.012354945,
0.011698693,
-0.0076741283,
-0.000853797,
0.021267915,
0.013995574,
0.0005591533,
0.0024810336,
-0.016218795,
-0.008832614,
-0.032651875,
0.004717647,
0.012729946,
0.010359404,
-0.016486652,
0.00059598376,
0.023477742,
-0.009930831,
-0.0013920239,
0.014183075,
0.013888431,
0.005199791,
-0.005454256,
-0.0022818143,
-0.0023571493,
0.008504488,
-0.019633982,
-0.0069910907,
0.0021646265,
-0.0055647474,
-0.005410729,
-0.023075957,
-0.025486678,
0.0041283597,
-0.01596433,
-0.025526855,
0.03993761,
0.01177905,
0.0020574834,
0.03476795,
-0.0050859516,
-0.025567034,
-0.026129536,
0.009093775,
-0.018629516,
-0.022379527,
0.01013842,
0.044062622,
-0.021763453,
-0.00079059927,
-0.005199791,
-0.007580378,
-0.015428614,
-0.012267891,
0.01637951,
0.011256727,
0.010111635,
0.025339356,
-0.029973296,
-0.012073694,
-0.013011197,
0.08383951,
0.0063884105,
-0.0070915376,
0.006204258,
-0.0030150753,
-0.024696497,
0.028767936,
0.01411611,
0.00944199,
0.030107226,
-0.017785763,
0.0053203274,
-0.028312579,
0.00015830819,
0.023317028,
0.007787968,
-0.035250098,
0.01795987,
-0.018843802,
-0.0049185404,
-0.017611656,
0.013044679,
0.033241164,
-0.009662973,
-0.009783509,
-0.006428589,
-0.027509004,
-0.003008379,
-0.023075957,
-0.005393988,
-0.0073192166,
0.009810295,
0.0055948817,
0.0024542478,
0.00074958353,
0.014812541,
-0.020049162,
-0.011712085,
0.022553634,
-0.0051428713,
-0.011471014,
0.0034988935,
0.0028376195,
0.0021177514,
-0.027937576,
-0.0067968937,
0.0052098357,
-0.024227746,
-0.015187542,
-0.0028409676,
-0.0137411095,
0.017437547,
-0.013821467,
0.015870579,
-0.057214443,
-0.018107193,
-0.031339373,
0.0016255626,
0.01554915,
-0.013453162,
-0.008899578,
0.03591974,
-0.024964355,
-0.0009358285,
0.011631728,
-0.17035761,
0.0155223645,
0.022379527,
-0.0006252807,
0.012803607,
-0.009080382,
0.0024659666,
0.0015644574,
-0.01330584,
-0.014772362,
0.03155366,
0.0040948773,
-0.05608944,
-0.0112969065,
-0.00934824,
0.007412967,
-0.0017243351,
0.021093808,
0.014584862,
0.014156289,
0.041517973,
-0.023343815,
-0.000539064,
0.0111562805,
0.005300238,
-0.008176362,
-0.009294668,
0.043526907,
-0.008102701,
-0.00893306,
-0.0015368346,
0.026558109,
0.033884022,
-0.016580403,
-0.028473293,
0.028339364,
-0.012127265,
0.004540191,
-0.009562526,
-0.0048783617,
0.019593803,
0.034714382,
-0.0076674316,
0.02359828,
-0.0028711017,
0.010486636,
0.029678654,
0.0076205567,
0.017062547,
-0.013995574,
0.012314766,
-0.022058096,
0.003008379,
0.004131708,
0.012140659,
-0.002472663,
0.0060000164,
0.00086049346,
0.0021478853,
0.00040429799,
-0.017799156,
-0.058339447,
0.026477752,
0.012441998,
-0.024187567,
-0.026357215,
-0.010379493,
-0.011912979,
-0.017986657,
0.013942002,
-0.019607197,
0.011906283,
-0.0059598377,
-0.026250072,
0.042000115,
0.014959862,
-0.028526865,
-0.004389521,
0.0026333777,
-0.026504537,
-0.0010429716,
0.011183066,
-0.041839402,
-0.014450933,
0.013372805,
0.02359828,
-0.0014280173,
0.0002613707,
0.013995574,
-0.030482227,
0.034312595,
-0.035276882,
0.00023730534,
-0.0155893285,
-0.0017628397,
0.0108080655,
-0.010747798,
-0.027884005,
0.006026802,
-0.020799164,
0.022138454,
-0.021683095,
-0.021294702,
0.01916523,
0.020571485,
0.013942002,
-0.016995583,
0.025392927,
0.054482292,
-0.0025044712,
-0.017892906,
0.008096005,
0.00578573,
0.017410763,
0.012187534,
0.036589388,
-0.0063884105,
-0.006261178,
0.015750043,
-0.0150670055,
0.03415188,
-0.02193756,
0.010660743,
0.0016197031,
0.017919693,
0.0012555838,
-0.11860747,
0.0016406295,
0.019044695,
0.026892932,
0.0034017952,
0.018575944,
-0.0134263765,
-0.017049154,
-0.016915224,
0.044357266,
-0.020718807,
-0.010245564,
-0.016459867,
0.0007085678,
0.05850016,
-0.0010680833,
0.0015159082,
-0.027254539,
0.0006943378,
0.045964412,
-0.0034486703,
-0.010205385,
0.0138080735,
-0.025888463,
0.008879488,
-0.026825966,
-0.034500096,
0.028473293,
0.012254498,
0.043607265,
0.0028091595,
-0.0070245727,
-0.018750051,
-0.0003264518,
-0.003760055,
-0.022325953,
-0.012790214,
-0.0041819313,
0.02698668,
-0.033803664,
0.0046038073,
0.019419696,
0.010433065,
-0.012348249,
0.015174149,
-0.024589354,
-0.03152687,
-0.00215793,
0.012649588,
-0.020464342,
-0.004764522,
-0.029035794,
-0.006395107,
-0.0018298042,
0.001424669,
-0.010225475,
0.007975468,
0.014839327,
-0.003803582,
0.004218762,
-0.002800789,
0.020169698,
-0.025071498,
0.03929475,
0.02633043,
-0.018843802,
-0.008437524,
-0.0006876414,
-0.002547998,
-0.003309719,
-0.028955437,
0.029035794,
-0.01869648,
0.00067048176,
-0.021000057,
-0.01739737,
-0.011665211,
0.004302467,
0.02420096,
-0.028259007,
0.016004508,
-0.009776813,
-0.0037332692,
-0.027884005,
0.008290201,
0.02045095,
-0.0060569365,
-0.0041886275,
0.0018482194,
-0.0058962214,
0.02906258,
0.021133987,
0.013901824,
-0.012843786,
0.027616147,
0.014906291,
-0.011839318,
-0.0013644011,
0.0023303635,
0.0037198763,
-0.020598272,
0.005494435,
-0.059946593,
0.017919693,
0.005179702,
-0.004533495,
0.005527917,
-0.00036265445,
0.030937586,
-0.0071317162,
0.010721012,
0.018910766,
-0.03364295,
0.031767946,
-0.027388468,
0.0031339373,
0.0072723413,
-0.0017293574,
-0.0024609442,
0.020852735,
0.0205447,
0.027696505,
-0.028473293,
0.00782145,
0.0007102419,
-0.0033448753,
-0.015375042,
-0.017852727,
0.01494647,
0.02304917,
-0.025580429,
-0.023116136,
0.02082595,
-0.0093750255,
-0.020584878,
-0.004493316,
0.00055957184,
-0.044625122,
0.016647367,
0.012053604,
0.03409831,
0.02128131,
-0.014973256,
-0.012562535,
0.010051367,
-0.01210048,
-0.014397361,
0.020236664,
-0.0030937586,
0.047651917,
-0.0138080735,
0.0016657412,
0.029839369,
0.0035759027,
0.0064922054,
-0.032544732,
-0.014705398,
0.009796902,
0.0010915209,
0.009040204,
0.0040848325,
-0.031071514,
0.021455416,
0.012555839,
0.004178583,
0.016272366,
-0.010118332,
-0.023129528,
0.0077477894,
-0.018736659,
-0.0003205924,
-0.0140893245,
0.0010848244,
-0.0061038113,
-0.005527917,
0.027884005,
0.010546904,
-0.013011197,
-0.0053136307,
0.023250064,
0.011953158,
0.022526847,
0.009167436,
0.015696472,
-0.0035457688,
0.025272392,
0.018910766,
0.018817017,
-0.012569231,
0.023665244,
0.0076607354,
0.0071986807,
-0.006331491,
0.016526831,
-0.006026802,
-0.005149568,
-0.018200943,
0.002156256,
0.010660743,
-0.0018565899,
0.032973304,
0.020156305,
0.004074788,
0.0111562805,
-0.024241138,
-0.029785797,
-0.022044703,
-0.0070915376,
0.0018817016,
-0.03924118,
-0.005929704,
0.00927458,
0.0055781403,
0.016901832,
-0.02045095,
0.003595992,
-0.009622795,
0.0064018033,
-0.016633974,
-0.022419704,
-0.0040413057,
0.028526865,
-0.01994202,
0.01892416,
0.012448695,
-0.0064788125,
0.013332626,
0.013915217,
0.009160739,
-0.00007439334,
0.007279038,
0.0019335991,
0.00042041132,
-0.0071384124,
-0.030107226,
-0.02578132,
0.01536165,
-0.007292431,
0.021897381,
-0.0039509037,
-0.00004174816,
0.07285734,
0.0018632864,
-0.028580436,
0.0063013565,
-0.022459883,
0.011096013,
0.0000069384087,
-0.0034553667,
-0.001901791,
-0.022031311,
-0.0032243393,
-0.01513397,
-0.014142896,
-0.057214443,
-0.011343781,
-0.00030510686,
-0.006515643,
0.010479939,
0.00023793313,
-0.016299153,
0.0101785995,
-0.01818755,
-0.008410738,
0.00075000204,
-0.03567867,
0.0008998351,
0.008732167,
0.009790205,
-0.01841523,
-0.023758994,
-0.015790222,
0.006646224,
-0.01076119,
-0.022915242,
0.01513397,
-0.0033766835,
0.0038102784,
-0.025553642,
0.017825942,
0.0007759508,
0.008524577,
-0.00539064,
-0.013942002,
-0.025245605,
-0.045401912,
-0.02591525,
-0.0022985553,
0.0023019037,
-0.010252261
] |
Genomes are arranged non-randomly in the 3D space of the cell nucleus. Here, we have developed HIPMap, a high-precision, high-throughput, automated fluorescent in situ hybridization imaging pipeline, for mapping of the spatial location of genome regions at large scale. High-throughput imaging position mapping (HIPMap) enabled an unbiased siRNA screen for factors involved in genome organization in human cells. We identify 50 cellular factors required for proper positioning of a set of functionally diverse genomic loci. Positioning factors include chromatin remodelers, histone modifiers, and nuclear envelope and pore proteins. Components of the replication | [
-0.03684013,
0.007339873,
-0.012112467,
-0.028287,
-0.023420563,
0.014626121,
-0.021329202,
0.011502486,
-0.005905414,
-0.0016707428,
0.013258693,
-0.013138038,
0.005583666,
0.0057110246,
-0.0026175529,
0.0050105527,
0.025900703,
-0.0114622675,
-0.01403625,
0.0008135864,
-0.04367727,
-0.0011571193,
0.010128355,
-0.027884815,
-0.010832178,
0.02476118,
0.0119582955,
-0.028501498,
-0.018286003,
-0.022120165,
0.013587144,
-0.000092691036,
-0.007366685,
-0.015765645,
-0.023862967,
0.021208547,
0.0092301415,
-0.011817531,
0.00759459,
-0.025659392,
0.0075409655,
0.010409884,
-0.016248267,
0.00006226533,
0.0072728423,
0.00526527,
-0.0009024022,
0.0030783897,
-0.010986349,
0.015859488,
0.0027499388,
0.033917587,
-0.0178436,
0.0011277933,
-0.007098562,
-0.021141516,
-0.013996032,
-0.014934463,
-0.0067164865,
-0.023862967,
-0.0042396984,
-0.0103562595,
-0.03150448,
0.016610233,
-0.0038944897,
-0.0048798425,
-0.0018919444,
0.003259373,
0.016462766,
-0.01342627,
0.036706068,
0.02559236,
-0.011408643,
0.003455438,
0.015162368,
-0.0009199978,
-0.004930116,
-0.014063063,
-0.013124632,
0.02528402,
0.023889778,
-0.010999755,
0.010101542,
0.011582923,
-0.0038810836,
0.008425772,
0.008231383,
0.014156906,
0.03150448,
-0.012306856,
0.0067533534,
0.021932479,
0.012574979,
0.0024516517,
-0.012353777,
0.0045715007,
0.016958794,
0.008962018,
0.0050675287,
-0.018728407,
-0.016945388,
0.01353352,
-0.021128109,
-0.012145982,
-0.018500501,
-0.017468227,
0.022079946,
-0.01279618,
0.019479152,
-0.012869914,
-0.00820457,
0.012192903,
-0.023876373,
-0.020296928,
0.027455818,
-0.02273685,
0.026021358,
-0.009551889,
-0.0047323746,
-0.012762665,
0.011381831,
0.016208049,
0.023098815,
-0.019076968,
0.025552142,
0.020015398,
-0.020967236,
-0.01630189,
-0.0039682235,
-0.01114052,
0.0027281537,
0.019841118,
0.0167577,
0.024600305,
-0.035794448,
-0.031075481,
0.014760183,
-0.0066360496,
-0.025538737,
-0.03694738,
0.014867432,
0.039762672,
-0.032523345,
-0.0037001004,
0.0045815553,
0.024171308,
0.010436696,
0.005620533,
0.020136055,
-0.006773463,
0.0030130346,
-0.014277562,
0.0022438562,
0.005583666,
0.017374385,
0.020806361,
-0.009143001,
0.008861472,
0.00033264037,
-0.020283522,
-0.0063511687,
0.005737837,
0.011113707,
0.02702682,
0.02482821,
0.021785012,
-0.0025622526,
-0.014518872,
-0.005379222,
-0.013111225,
-0.00096859515,
0.0020394123,
-0.05523338,
-0.004008442,
0.0040252,
0.009370906,
-0.0016229834,
0.00822468,
-0.024975678,
-0.031477667,
0.006186943,
0.017066043,
0.00937761,
0.00016338758,
-0.01571202,
-0.0011529298,
0.01714648,
-0.0151355555,
0.014170312,
-0.029118182,
0.0010046242,
-0.011636548,
-0.0050273105,
-0.007339873,
-0.6409217,
-0.009712763,
0.018942906,
-0.043221463,
0.011267878,
0.032416098,
0.011904671,
0.010664601,
0.001319669,
0.032684222,
-0.0028488091,
0.02898412,
0.0020142756,
-0.012367183,
-0.049844105,
-0.04987092,
0.007996775,
-0.018768625,
0.04067429,
0.006297544,
-0.024613712,
-0.015725426,
0.009169814,
0.010061324,
0.007581184,
0.023474189,
0.03799306,
-0.00393806,
-0.0103562595,
0.02989574,
-0.03257697,
0.004665344,
-0.027147476,
-0.009632327,
0.044669326,
-0.0052518635,
-0.008995534,
0.030405173,
0.020578457,
0.03694738,
-0.010671305,
-0.027040226,
0.016395735,
0.012561573,
-0.01077185,
0.011515892,
0.0052451603,
-0.009840122,
0.010456805,
-0.013184959,
0.006233865,
0.01547071,
-0.020404177,
0.022669818,
0.0021902316,
-0.0054931743,
0.011086895,
0.010671305,
0.026517386,
0.0029694648,
-0.0116432505,
0.0107852565,
-0.032469723,
-0.024680743,
-0.028152937,
0.010054621,
-0.010791959,
0.0031722328,
0.011127113,
-0.011763906,
0.0030163862,
0.010952833,
-0.007165593,
-0.010329447,
0.018460283,
0.030753734,
0.007668324,
-0.001712637,
0.0032308847,
0.010476915,
0.0010146789,
0.0011328206,
-0.021275578,
-0.004893249,
0.003629718,
0.012890024,
-0.034856018,
0.026705073,
-0.008452584,
-0.01640914,
0.016208049,
-0.0022237469,
0.0013163175,
-0.035848074,
-0.029171806,
0.0037838889,
-0.0062807864,
0.0104031805,
0.005328949,
-0.028501498,
-0.007098562,
-0.008285007,
-0.013298912,
0.018312816,
0.023688687,
0.0044709546,
-0.020578457,
0.02569961,
0.026235856,
-0.010631085,
-0.007929744,
-0.0079230415,
-0.025485111,
0.004021848,
0.007802386,
-0.024922052,
0.03405165,
0.023769123,
-0.010490321,
-0.018929498,
0.02311222,
-0.010812068,
0.011408643,
-0.018902687,
0.028394248,
0.013915595,
0.014384811,
-0.010362962,
-0.012125872,
-0.010450102,
-0.0007155538,
-0.025069522,
0.023501,
-0.021101298,
0.009437937,
0.0069577973,
0.0014017817,
0.0015827649,
-0.0031320143,
-0.02639673,
-0.022307852,
-0.019398715,
0.0065857763,
-0.004628477,
-0.009075971,
-0.025404675,
-0.032067537,
-0.013453082,
0.027187694,
-0.023031784,
-0.009759685,
0.01146897,
-0.020524831,
0.020189678,
0.01686495,
-0.01316485,
-0.010021105,
-0.039789487,
-0.0022958051,
-0.034909643,
0.017508445,
0.018688189,
-0.002982871,
-0.0030800654,
0.00937761,
-0.02863556,
0.0048295693,
0.024466245,
-0.002280723,
-0.028742809,
0.014357998,
0.00061500765,
-0.04340915,
0.016087392,
0.0009702709,
0.017360978,
0.010845584,
-0.0010180303,
-0.0056574,
-0.016744295,
-0.0015090309,
-0.00998759,
-0.026812322,
-0.014411623,
0.02957399,
-0.009303875,
0.047725935,
0.015443898,
0.0038475683,
0.011220956,
0.0038174044,
0.00070130976,
-0.008063806,
0.017870413,
0.015631584,
0.007634809,
-0.0004074216,
-0.00017962161,
-0.00070089084,
0.013634066,
0.015685208,
-0.0013506707,
-0.01077185,
-0.031450853,
0.02713407,
-0.02989574,
0.0021634193,
-0.029842114,
-0.016060581,
-0.010879099,
0.00021785012,
0.009692654,
-0.006321005,
-0.008030291,
0.010825475,
-0.0028186454,
-0.013138038,
-0.0067835175,
-0.00020035927,
0.013365942,
0.0063478174,
-0.0035559842,
0.034695145,
0.008392257,
0.004930116,
-0.004688805,
0.013915595,
0.016221454,
0.0128363995,
-0.008673786,
-0.0045011183,
0.02091361,
-0.012501245,
0.011019864,
0.026517386,
0.0060026087,
0.005620533,
-0.008854769,
0.021503482,
0.020283522,
0.015604772,
0.008955316,
-0.004206183,
-0.012474433,
0.019197622,
-0.009310579,
0.018379847,
0.015028306,
-0.0057612974,
-0.009652436,
-0.013607253,
-0.020752737,
-0.013091116,
0.02325969,
0.013272099,
-0.01386197,
0.014840621,
-0.008935207,
0.05796824,
0.020350553,
-0.005838383,
0.00415591,
-0.001990815,
-0.016154423,
0.0019489207,
-0.019211028,
0.018286003,
-0.009679249,
-0.022254227,
0.011716984,
-0.007500747,
0.0056171813,
0.014518872,
-0.019331684,
0.00079808553,
0.00022497214,
0.013178256,
-0.000634279,
0.017991068,
-0.0030716867,
-0.0074002007,
-0.03405165,
0.030137049,
0.03614301,
-0.006341114,
-0.009015643,
-0.02772394,
-0.019479152,
-0.008720708,
-0.0077755735,
0.00040365112,
0.002026006,
0.0055199866,
-0.0034956564,
-0.011509189,
-0.018151943,
0.034936454,
-0.0012702338,
0.0007850983,
0.00009750888,
-0.00072058116,
-0.021221953,
-0.0026678261,
-0.0100412145,
0.0372155,
0.012735853,
0.0019422176,
0.004062067,
0.004273214,
-0.009384313,
-0.011690172,
-0.018205566,
0.012916836,
0.003964872,
-0.007091859,
0.0019841117,
-0.027321756,
0.011649954,
0.024707554,
0.010503727,
-0.017052637,
-0.029734865,
-0.008707302,
0.0055233384,
0.0339444,
0.012179498,
-0.014063063,
0.00472232,
-0.01592652,
0.013365942,
-0.0006296706,
-0.015229398,
0.01105338,
-0.011502486,
-0.009384313,
0.006793572,
0.0022254228,
0.008117431,
-0.002763345,
0.0215437,
0.014183718,
-0.021141516,
-0.026490575,
0.005409386,
-0.009075971,
-0.00829171,
0.008861472,
0.027777566,
0.026195638,
-0.0055065807,
0.03474877,
0.03662563,
-0.0071119685,
-0.017588884,
-0.018353034,
0.02077955,
0.005633939,
0.015618177,
0.0013858619,
-0.022602787,
0.019318277,
0.0030582806,
0.006217107,
0.00911619,
0.014009438,
0.013848565,
0.015591365,
-0.0040989337,
-0.0021600677,
0.014559091,
0.007178999,
0.015591365,
-0.025605768,
-0.0045379857,
0.021235358,
-0.034480646,
-0.0005073394,
-0.040003985,
0.0005215834,
-0.007366685,
-0.009210032,
-0.0057244305,
-0.0044575487,
-0.022200603,
-0.0023309963,
-0.020001993,
0.0020695762,
-0.004192777,
-0.014599309,
-0.00961892,
-0.00813754,
-0.009102783,
-0.017897224,
-0.020350553,
0.0127023375,
-0.04271203,
-0.03257697,
-0.0109662395,
0.03533864,
0.0070382343,
0.0056305877,
0.00014998142,
-0.008043696,
0.019934962,
-0.010423291,
-0.028662372,
0.001064114,
-0.027858002,
-0.010215495,
0.011241066,
0.00095518894,
-0.01592652,
-0.0045513916,
0.00041957095,
0.015953332,
-0.026289482,
0.020833174,
0.01686495,
-0.024948865,
0.02643695,
0.020162866,
0.014089875,
0.006213756,
-0.007406904,
-0.0021634193,
-0.0415591,
-0.017119667,
-0.019572996,
0.0015417085,
-0.0074806376,
-0.01059757,
-0.007473935,
-0.021221953,
-0.028421061,
0.00095518894,
-0.006669565,
-0.0026410136,
-0.00086050795,
0.041505475,
0.013955814,
0.0073800916,
0.020927018,
-0.018433472,
0.002426515,
-0.008130836,
-0.00295941,
0.022388289,
0.002093037,
-0.000087611355,
0.014894245,
-0.005379222,
-0.016476171,
-0.03094142,
-0.00076457014,
-0.010275822,
0.0487448,
0.009062565,
-0.014532278,
-0.009297173,
-0.018849062,
-0.0038576229,
0.007514153,
0.010000996,
-0.009062565,
-0.015443898,
-0.0036062573,
0.0038509197,
-0.02744241,
-0.0033280794,
-0.03126317,
0.013808345,
0.013486598,
0.0117505,
0.0046753986,
-0.00016223549,
0.008915097,
-0.024426024,
-0.017883819,
-0.018688189,
-0.014411623,
0.00095518894,
-0.010409884,
0.038609743,
0.01906356,
0.021986105,
0.030700108,
-0.00020831918,
0.020940423,
0.01379494,
-0.0006292517,
0.002084658,
0.009136299,
-0.027174288,
0.018875875,
0.015081931,
0.016261673,
-0.001363239,
-0.014907651,
0.00707175,
0.022643005,
-0.015685208,
-0.02060527,
0.030083425,
-0.040352546,
-0.023474189,
-0.016154423,
-0.011904671,
-0.009075971,
-0.021221953,
0.00085129123,
0.012655416,
0.0059288745,
0.023702092,
-0.021945886,
0.024466245,
-0.018205566,
0.03185304,
0.0042028315,
0.024801398,
-0.0060461788,
0.00021680276,
-0.023836154,
0.005942281,
0.037912622,
-0.011274582,
0.029037744,
0.014130093,
0.0020276818,
0.008325226,
0.0033113218,
-0.023179252,
0.004313432,
-0.01638233,
-0.016154423,
-0.006890767,
-0.02356803,
-0.016529797,
-0.035982136,
0.00724603,
-0.012829696,
-0.0059121167,
0.024640523,
-0.0024114333,
0.009310579,
0.0067030806,
0.03625026,
0.020752737,
-0.00578811,
0.035419077,
0.012058842,
-0.0007955719,
-0.040942416,
0.0014864081,
-0.00909608,
0.01669067,
0.05000498,
0.014290968,
-0.0020427639,
-0.016087392,
0.022696631,
-0.00342695,
-0.0042396984,
-0.049415108,
0.015872894,
-0.0026510684,
-0.008908394,
-0.013781534,
0.0012886672,
-0.02661123,
-0.0013305615,
0.0016439304,
0.025337644,
-0.007178999,
-0.010517133,
-0.019814305,
0.0053390036,
0.0013071006,
0.014532278,
-0.0025974438,
-0.038556118,
-0.0053926283,
-0.010208791,
0.009652436,
-0.00034646547,
0.010121652,
0.013365942,
0.003549281,
-0.004162613,
0.018822249,
0.013768127,
0.0046351803,
-0.017200105,
0.008995534,
0.040701106,
-0.03614301,
-0.00911619,
0.024238339,
0.016891763,
0.020980641,
0.020109242,
-0.0022455319,
0.0033515403,
-0.0020578457,
0.007366685,
0.011120411,
0.008392257,
0.0015877922,
-0.014880839,
-0.0112142535,
-0.0017763163,
-0.02761669,
-0.0071186717,
0.0010322743,
-0.046492565,
-0.009451344,
0.014076469,
0.036572006,
0.027509442,
0.025176771,
0.0008265736,
-0.015283023,
0.026517386,
-0.030753734,
0.02339375,
0.027361974,
-0.008553131,
-0.05206953,
0.015805863,
-0.015832676,
-0.01270904,
-0.004021848,
-0.025726423,
-0.020873392,
0.013138038,
0.008734114,
0.022200603,
0.01969365,
-0.019948367,
-0.005349058,
-0.00027524523,
0.0039916844,
-0.009766389,
-0.013660878,
0.001217447,
-0.044964265,
0.011649954,
0.007004719,
-0.02308541,
-0.0012132576,
-0.026624635,
-0.015510928,
0.022039728,
-0.015041713,
-0.029708052,
-0.006625995,
0.014022844,
0.0010557352,
0.006501988,
-0.00681033,
-0.0077018393,
-0.020940423,
0.015443898,
-0.008164352,
0.0065790736,
0.00027503577,
0.0097932005,
0.016891763,
0.013184959,
-0.010114948,
-0.003549281,
-0.012735853,
-0.027750753,
-0.03627707,
0.015041713,
-0.008023587,
0.034105275,
0.016529797,
-0.03187985,
-0.0300298,
-0.01703923,
-0.043141026,
-0.03453427,
0.023809342,
-0.00019051411,
-0.009893747,
0.015980143,
-0.0084861,
0.00071974326,
-0.0061701857,
0.006639401,
0.033971213,
-0.004145855,
0.0041827224,
-0.009042456,
0.029708052,
0.017924037,
-0.024452837,
-0.012983867,
0.008868176,
0.017226918,
-0.019318277,
0.020484613,
-0.0014269182,
0.038529307,
-0.00022287742,
0.006240568,
-0.0032442908,
0.025015896,
0.024251744,
-0.016824732,
-0.003777186,
-0.004119043,
0.0036464757,
-0.021490077,
0.0028672426,
-0.016570015,
0.005654048,
0.009605514,
-0.020216491,
-0.01860775,
0.032389283,
-0.01007473,
0.0094111245,
0.014076469,
-0.001363239,
0.023702092,
0.013205068,
-0.0070248283,
-0.00072560844,
-0.023313314,
-0.021114703,
-0.007266139,
0.001990815,
-0.011911374,
-0.003448735,
0.012682228,
-0.0057478915,
-0.028689185,
-0.021731386,
0.0046150708,
-0.024573494,
-0.01536346,
0.0076214024,
0.007842604,
-0.0005132046,
-0.020685706,
-0.024506463,
-0.030351548,
-0.014907651,
0.012393996,
-0.012507948,
-0.008278305,
0.029359492,
0.0046519376,
-0.01673089,
-0.02946674,
0.0044072755,
0.0047792965,
-0.007427013,
0.013680987,
0.19347772,
-0.010269119,
0.013660878,
0.0102892285,
-0.0031906662,
-0.0067198384,
0.023165846,
0.009283766,
0.006817033,
-0.00981331,
0.0105372425,
0.00088732026,
-0.014116688,
0.0043838145,
0.018942906,
0.0013355887,
-0.024385806,
-0.011985108,
-0.022710036,
0.013821752,
0.013044194,
-0.008285007,
-0.0254583,
-0.000053362804,
0.01686495,
-0.0056473454,
-0.037242316,
0.02102086,
-0.00072854105,
0.014277562,
-0.030566046,
0.008707302,
0.021972697,
0.002456679,
0.008184461,
0.0052954336,
-0.0002207827,
0.012179498,
-0.008881582,
-0.0013900513,
-0.02661123,
0.0024214878,
-0.0016389032,
-0.004212886,
0.01031604,
-0.003031468,
0.0051513175,
-0.00090491585,
-0.008613459,
0.0052451603,
-0.028715996,
0.0013255342,
0.001814859,
0.046707064,
-0.015913112,
-0.00042250354,
0.006699729,
0.0055434476,
0.006116561,
0.036116198,
-0.0052284026,
0.006823736,
-0.0150685245,
-0.0033867315,
-0.018715,
0.018688189,
-0.015336648,
0.006290841,
0.025994547,
-0.020484613,
0.018379847,
-0.006850548,
-0.02293794,
-0.0054563074,
-0.0084861,
-0.0022840747,
0.0502731,
0.0060931,
0.031370416,
0.0072192177,
0.026651448,
-0.0071924054,
-0.036866944,
0.006689674,
0.015792457,
-0.028742809,
0.03303278,
0.006991313,
-0.0060830456,
-0.015591365,
0.0009526753,
-0.005124505,
-0.011274582,
-0.015792457,
-0.010926021,
0.002632635,
-0.0055233384,
0.01270904,
-0.039226428,
-0.01183764,
-0.020082429,
0.060434975,
0.019438934,
0.00631095,
0.011676766,
-0.00911619,
-0.0024231635,
0.004149207,
-0.008566537,
-0.015122149,
0.023232877,
-0.041612722,
0.013171553,
-0.0022555867,
0.006146725,
0.023058597,
0.017749757,
-0.05357102,
0.05021948,
0.006682971,
-0.018379847,
-0.0063377623,
0.00033264037,
0.039467737,
-0.010295931,
-0.009082674,
-0.02336694,
0.007085156,
-0.009766389,
-0.034561083,
0.014786995,
0.018822249,
0.01721351,
0.024291964,
0.016784513,
-0.032737844,
-0.00846599,
0.001057411,
-0.035070516,
0.008667083,
-0.012910133,
-0.021878855,
0.0116432505,
0.016181236,
0.0018282651,
-0.0031370416,
0.013573738,
0.017025825,
-0.0015609799,
-0.012890024,
-0.0063880356,
-0.006518746,
0.007634809,
0.0021399583,
0.024962272,
-0.02210676,
-0.0023511054,
-0.04032573,
-0.0150149,
0.017736351,
-0.027268132,
0.013567035,
0.01658342,
0.007889526,
-0.009645733,
0.0010138409,
-0.16956112,
-0.015497522,
0.026517386,
-0.028260186,
0.012789478,
0.020028803,
0.004119043,
0.008754223,
0.014089875,
0.022079946,
0.0034101922,
-0.0035894995,
-0.017870413,
-0.03751044,
0.013446379,
0.017401196,
-0.0141435,
0.04158591,
0.022750255,
0.0022237469,
-0.00016715807,
-0.01686495,
0.030914607,
0.0020427639,
0.00071010756,
0.0013305615,
-0.021074485,
0.011160629,
-0.0015199234,
-0.02989574,
-0.0032426151,
-0.0015484116,
0.025270613,
-0.0041525583,
0.009062565,
-0.0072862483,
-0.017897224,
0.016208049,
-0.015671803,
-0.0013381024,
0.020833174,
0.02032374,
0.0059087654,
-0.020940423,
-0.0048161633,
0.019988585,
0.014290968,
-0.02447965,
0.018393252,
-0.002937625,
-0.0037704827,
-0.009243548,
-0.0071991086,
0.023031784,
0.03255016,
-0.013888783,
-0.009149705,
0.0274156,
0.012005217,
-0.0016958794,
-0.029520366,
-0.016784513,
0.02724132,
-0.018151943,
-0.014652934,
-0.037269127,
-0.007406904,
0.001895296,
-0.023433968,
0.010342853,
-0.010081433,
0.005503229,
0.003499008,
-0.009223439,
0.019720463,
0.014518872,
0.0026678261,
0.0062070526,
0.014746777,
-0.0008923476,
-0.014223937,
0.018983124,
-0.0076012933,
-0.052847087,
-0.009250251,
-0.015577959,
-0.012259934,
0.02108789,
-0.017414603,
0.010195386,
0.029815301,
-0.01732076,
0.0015215992,
0.0023879723,
0.044052646,
0.016596828,
0.002289102,
-0.01122766,
0.016489578,
-0.028769622,
0.010302635,
0.006277435,
-0.0393873,
0.01638233,
0.035258204,
-0.0039715753,
0.0030666592,
0.0030499017,
0.053892765,
-0.00017438483,
-0.021838635,
-0.015792457,
0.010195386,
0.023876373,
-0.0034520864,
0.021516887,
-0.0065958314,
-0.0070382343,
0.009994293,
-0.011160629,
0.06338433,
-0.013573738,
-0.026410136,
0.03094142,
0.0009903802,
-0.00393806,
-0.1285919,
-0.014719965,
0.0062807864,
0.011884562,
-0.008673786,
0.021007454,
0.010007699,
0.0118443435,
-0.015309836,
0.030110238,
-0.042095345,
-0.027201101,
-0.025444893,
-0.0054395497,
-0.0014595957,
0.005664103,
-0.023353532,
-0.0034721957,
0.0061031547,
0.025498519,
-0.0067902203,
-0.009759685,
0.002093037,
-0.021878855,
0.01449206,
-0.011522595,
-0.03520458,
0.010798663,
0.021664357,
0.007091859,
-0.00040197535,
-0.022012915,
0.005054123,
0.0060528815,
-0.0053591128,
-0.00069125515,
-0.010993052,
-0.031745788,
0.019452339,
0.0043067294,
-0.006729893,
0.012843102,
0.0028320516,
0.01599355,
0.008090618,
-0.010577461,
0.0013171553,
0.0015735482,
-0.006213756,
-0.00724603,
-0.018084912,
-0.014170312,
-0.038636554,
-0.019894743,
0.00398163,
-0.028715996,
0.012393996,
-0.014022844,
0.0023477538,
-0.006977907,
0.012420808,
0.006029421,
-0.004440791,
0.005868547,
0.021516887,
-0.009980887,
-0.028045688,
-0.02702682,
0.027254725,
-0.020444395,
-0.015671803,
0.021557108,
-0.017052637,
-0.0028102666,
-0.02933268,
-0.00707175,
-0.026142014,
0.003405165,
0.018567532,
-0.014505466,
-0.004729023,
-0.024533274,
0.050997037,
-0.03201391,
0.021972697,
0.022857504,
0.0030297923,
0.0021315797,
0.013667581,
-0.0043469477,
0.001567683,
0.040245295,
-0.011301394,
-0.023554625,
-0.018205566,
0.004430736,
-0.009518375,
0.0035894995,
-0.0013540223,
0.0039112475,
-0.045446884,
0.015939925,
-0.05426814,
-0.002791833,
-0.00570097,
-0.0069242823,
0.0030147105,
-0.037376378,
-0.008258195,
0.012427512,
0.011294691,
0.013124632,
-0.016234862,
0.0024449485,
-0.0145724965,
0.0017913983,
-0.024104277,
-0.022307852,
0.021932479,
0.009391015,
0.012172794,
0.028421061,
0.011247769,
0.005137911,
0.0053088395,
0.008868176,
-0.004933467,
0.011770609,
-0.017508445,
0.025820266,
-0.021208547,
-0.016529797,
0.023018379,
0.00079976127,
-0.017682726,
0.015403679,
0.010181979,
-0.015537741,
0.0014394865,
0.010791959,
0.02702682,
0.016677264,
-0.022857504,
-0.038046684,
-0.008566537,
0.021878855,
0.0012802883,
0.010309338,
-0.018688189,
0.0061835917,
0.000699634,
-0.02293794,
0.042283032,
0.021141516,
0.0030800654,
-0.015041713,
-0.040727917,
-0.00317726,
0.0015266265,
0.012782775,
0.004484361,
-0.02598114,
0.019076968,
0.03520458,
0.0064617693,
0.0016707428,
-0.020819768,
-0.009887043,
-0.025015896,
0.004789351,
0.0072326236,
-0.03327409,
-0.033327717,
0.013996032,
0.013526816,
0.0034923048,
0.0000018754224,
-0.00089653704,
-0.012045436,
-0.008244789,
0.0071253744,
0.010912615,
0.015765645,
0.0071924054,
0.00084458815,
0.024881834,
0.045554135,
-0.01114052,
-0.0007084318,
0.026772104,
-0.010939428,
0.0007838415,
-0.027750753,
0.013198365,
0.028045688,
0.030673295,
0.0024499758,
0.028501498,
-0.005037365,
0.020404177,
0.013553629,
0.014894245,
-0.007165593,
-0.0011143872,
0.012890024,
-0.017830195,
-0.0094111245,
0.012755962,
0.000663186,
-0.016342111,
0.009458046,
0.010047917,
-0.0014629473,
0.007098562,
0.007996775,
-0.00046963457,
-0.017159887,
0.015443898,
0.0024734368,
-0.0032677518,
-0.021288984,
0.022830691,
0.027938439,
0.02339375,
-0.008057103,
-0.010181979,
0.032308847,
0.019707056,
0.0117773125,
-0.026839133,
0.008150945,
-0.008130836,
0.024600305,
0.014304373,
0.004410627,
0.010275822,
-0.021221953,
-0.0043871664,
0.007366685,
-0.0010188682,
0.0035861481,
0.08108046,
-0.004564798,
-0.015738834,
0.0039514657,
-0.03131679,
0.0026929625,
0.016958794,
0.011703579,
-0.018527314,
-0.018098317,
0.026825728,
-0.024050653,
0.021610731,
-0.03142404,
0.004977037,
0.0064617693,
-0.01864797,
0.018715,
-0.020591862,
0.0023427266,
0.009954074,
-0.031584915,
0.009250251,
0.02136942,
-0.0337299,
0.013969219,
0.027294943,
-0.00007860409,
0.00109344,
-0.006106506,
0.01077185,
-0.019921554,
-0.030083425,
-0.004108988,
-0.0014537306,
0.02025671,
0.0117773125,
0.0058517894,
0.0319871,
0.019117186,
0.004796054,
0.0021667709,
0.0034755473,
-0.03509733,
-0.006022718,
0.018312816,
-0.00084375025,
-0.009176517,
0.0013138037
] |
Afferent activity can induce fast, feed-forward changes in synaptic efficacy that are synapse specific. Using combined electrophysiology, caged molecule photolysis, and Ca(2+) imaging, we describe a plasticity in which the recruitment of astrocytes in response to afferent activity causes a fast and feed-forward, yet distributed increase in the amplitude of quantal synaptic currents at multiple glutamate synapses on magnocellular neurosecretory cells in the hypothalamic paraventricular nucleus. The plasticity is largely multiplicative, consistent with a proportional increase or "scaling" in the strength of all synapses | [
-0.027593084,
0.011903158,
0.010075977,
-0.021873211,
-0.025540816,
0.013518493,
0.004455409,
0.0019943418,
-0.024587503,
-0.022058578,
0.026454406,
0.01848366,
-0.007282244,
-0.000087407614,
-0.014259958,
-0.010612215,
0.03855617,
0.015345674,
-0.029393785,
0.022548474,
-0.02150248,
0.03018821,
-0.0023170775,
-0.020972863,
-0.007030675,
0.023144295,
-0.008890958,
-0.034213305,
-0.009725106,
-0.015491319,
0.0074874707,
0.0075933943,
0.0030784032,
0.002782148,
0.01016866,
-0.019052997,
0.015067625,
-0.024878792,
0.015703166,
0.0085400855,
-0.003819868,
0.0023899,
-0.013677378,
-0.01106239,
-0.006209768,
-0.005137292,
-0.004253492,
-0.012538699,
0.0017675991,
0.012743927,
0.043481614,
0.008983641,
-0.008877717,
0.0033547974,
0.0019347598,
-0.006663253,
0.018338013,
0.017781915,
0.031882986,
-0.014882258,
-0.010976328,
0.009043223,
-0.016219543,
0.029526189,
-0.0057794536,
0.018443938,
0.0065209186,
0.027407717,
0.009043223,
-0.01075124,
0.009314652,
0.02989692,
-0.0161401,
-0.02178053,
0.02450806,
0.005554366,
-0.0076595964,
0.00040362665,
-0.020430004,
0.02597775,
0.015967974,
-0.033657208,
-0.017689232,
0.04181332,
-0.006818828,
-0.010254723,
-0.012227549,
0.008314999,
0.011433123,
0.0022177743,
0.0076662167,
0.028096221,
0.018338013,
0.02360771,
0.024071125,
0.015425117,
-0.013399329,
0.03826488,
-0.013306646,
-0.0032604593,
-0.003020476,
-0.0006251972,
-0.005951579,
-0.020787496,
0.010075977,
0.0015598898,
-0.013849503,
0.00388276,
0.029420266,
-0.007229282,
-0.0075139515,
0.0074146483,
0.0014531387,
-0.026705975,
-0.0077257985,
0.011777374,
0.025633499,
-0.0054219617,
-0.0046507055,
-0.0074212686,
0.0073285853,
0.014418843,
0.024666946,
0.016312227,
0.018721987,
0.03257149,
0.023435585,
0.0058158645,
-0.019476691,
-0.0085400855,
0.0033382468,
0.024150569,
0.021661365,
0.019463452,
-0.025474614,
0.0086460095,
0.0066500125,
0.010618836,
-0.011539047,
-0.029023051,
-0.00955298,
0.013233823,
-0.026772177,
0.013492011,
-0.012366574,
0.042925518,
0.0079045445,
0.013677378,
0.026984023,
0.007792001,
0.0056371186,
-0.007818482,
-0.009758207,
0.00041852213,
0.005574227,
0.0010211692,
0.00089786755,
0.017689232,
-0.029393785,
-0.017583309,
0.0027407717,
-0.016510833,
0.00031032288,
-0.0034425154,
0.0010286169,
0.010969708,
-0.0009309687,
-0.025739422,
0.0082554165,
-0.021317113,
-0.015689926,
0.021184709,
-0.0066698734,
0.04176036,
-0.019595856,
0.0011841921,
0.025593776,
0.01553104,
-0.03288926,
-0.024600744,
-0.010049497,
-0.008520225,
-0.0025736112,
-0.0053259684,
0.009420576,
0.0028682111,
0.023806317,
-0.041733876,
-0.0069777137,
-0.009301411,
0.0041012275,
0.0032521838,
-0.052644003,
-0.015967974,
-0.646981,
-0.01674916,
0.0144453235,
-0.033604246,
-0.012829989,
0.032439087,
0.0042865938,
-0.01016866,
-0.0012437742,
0.01611362,
-0.031724103,
0.022190982,
-0.0016807087,
-0.021873211,
-0.01914568,
-0.028466953,
-0.009096185,
-0.0060376422,
0.015584002,
0.0074808504,
-0.011486084,
-0.010989568,
-0.017755434,
0.02328994,
0.01105577,
0.015120586,
0.0103076855,
-0.028440472,
-0.014286438,
0.034186825,
-0.023991683,
0.028572876,
-0.0022757011,
-0.011552287,
0.04472622,
0.01104253,
0.0031677762,
0.03490181,
0.0060806735,
0.043958273,
-0.021052305,
-0.0055080242,
0.010261344,
0.02360771,
-0.032306682,
-0.011598628,
-0.0039291014,
0.00034176893,
0.005875447,
-0.035696235,
0.022786804,
-0.0038132477,
-0.027248833,
0.031300407,
0.030373577,
0.010261344,
0.025037678,
0.00983765,
-0.0012512219,
0.006832069,
0.010989568,
0.0056801504,
-0.013849503,
-0.028175663,
0.0018685575,
-0.0033994839,
-0.0071167382,
0.005938339,
0.00070339855,
0.02599099,
0.02777845,
0.009797928,
0.0087850345,
0.004452099,
0.014432083,
0.0029625492,
0.0033216963,
-0.0050611594,
-0.014816056,
0.013650897,
-0.005703321,
-0.003670913,
-0.043190327,
0.0044289283,
-0.012002462,
0.0061998377,
-0.02058889,
0.018748468,
-0.00033845883,
-0.008619528,
0.015716406,
0.004220391,
-0.027990296,
-0.04509695,
-0.03495477,
0.018443938,
-0.0092484495,
0.014802815,
0.011307338,
-0.011492705,
-0.02298541,
-0.007110118,
-0.0062230085,
0.0088578565,
0.036596585,
0.024627225,
-0.021118507,
0.0030386818,
0.036358256,
-0.028334549,
0.0050578495,
-0.011254377,
-0.0072690034,
-0.012671105,
-0.0040747463,
-0.027884373,
0.013247063,
-0.0033730029,
-0.003224048,
-0.01315438,
0.00041459137,
0.0009781377,
0.0047698696,
0.000058754467,
0.009016742,
0.012412916,
-0.0055047143,
-0.014802815,
0.00091607316,
-0.0054484424,
0.00045596776,
-0.008837996,
0.021965895,
0.0007472575,
0.020363802,
-0.004362726,
0.029446745,
0.0018255261,
0.0131279,
-0.038053036,
-0.031009119,
-0.004329625,
-0.0073616863,
-0.015875291,
-0.002002617,
-0.01645787,
-0.028519915,
0.0130285965,
0.0060508824,
-0.011843577,
-0.0006777452,
-0.00897702,
0.0029294482,
0.005104191,
0.03106208,
-0.0144453235,
-0.009453677,
-0.00687179,
0.0039820634,
-0.036517143,
0.0017245677,
0.026454406,
-0.009513259,
0.027036985,
-0.030558944,
-0.013968668,
-0.0038000073,
-0.001913244,
0.009195488,
-0.027937336,
0.0023104574,
-0.026560329,
-0.012280512,
0.024839072,
-0.013002115,
0.00021846732,
-0.016351948,
-0.0033647276,
-0.003076748,
-0.009188868,
0.0017527037,
-0.015994456,
-0.013108039,
0.00089455745,
0.039244674,
0.01579585,
0.018735228,
0.03286278,
-0.0026795347,
0.0016682958,
0.009486778,
0.03762934,
-0.023210498,
-0.0016898116,
-0.026811898,
-0.03251853,
0.005352449,
0.004240252,
-0.0070240553,
0.036172893,
0.0286788,
-0.0076993178,
0.030876715,
0.0057761436,
0.019569375,
-0.010691658,
0.0013993493,
-0.029790998,
0.0017510486,
0.0016236093,
0.005339209,
-0.008672491,
-0.0019877215,
-0.027434198,
-0.016643237,
0.010989568,
-0.0018304912,
0.025593776,
0.008036949,
-0.021912934,
0.010493051,
-0.006001231,
0.04091297,
0.020390283,
-0.0064580264,
0.049122047,
-0.020734534,
0.025620257,
-0.022032097,
-0.0054021007,
0.015729647,
0.0065904306,
0.022667639,
0.030505981,
0.0049684765,
-0.011671451,
-0.00164347,
0.0027871134,
0.030294135,
0.03614641,
0.022839764,
0.011810475,
-0.016179822,
0.019476691,
-0.01762303,
-0.01824533,
0.0113272,
0.00687179,
-0.014206995,
-0.008275277,
-0.0062859003,
0.015742887,
0.0073021045,
0.0047599394,
-0.0057595926,
0.0021432969,
0.008520225,
0.00808329,
0.016272506,
0.030929675,
-0.009665524,
0.013233823,
-0.014206995,
0.005610638,
-0.022813285,
0.011850197,
0.008030329,
-0.006640082,
-0.011790615,
-0.01852338,
-0.022588197,
-0.010281204,
-0.021475999,
-0.020787496,
0.008632769,
-0.012849851,
0.0031346749,
0.013770062,
0.006739386,
-0.002065509,
-0.024865553,
-0.034848846,
0.020416765,
0.00025818864,
-0.0014638965,
-0.0023716944,
-0.0315917,
0.012922673,
-0.008195834,
-0.02388576,
-0.011625109,
0.0046937373,
-0.017517107,
-0.014140793,
-0.01584881,
-0.013472151,
0.014789575,
-0.0025504404,
0.0050710896,
-0.033922017,
-0.007441129,
0.0148690175,
-0.027540123,
0.0062230085,
0.024958236,
0.015928254,
-0.0148690175,
-0.010261344,
-0.011744273,
-0.01821885,
0.014114313,
0.013862744,
-0.009235209,
0.0035782298,
0.01795404,
0.0030370266,
-0.003103229,
-0.0036642926,
0.035087176,
0.008996882,
-0.010963087,
-0.021608403,
-0.001477137,
-0.015425117,
0.033312954,
0.017358221,
-0.015014662,
0.013121279,
-0.008149493,
-0.0116515905,
-0.02119795,
0.005104191,
0.014683652,
-0.02328994,
-0.013498632,
-0.0054021007,
0.020721294,
0.0041674296,
0.016656477,
0.012896192,
-0.0013480426,
-0.003968823,
-0.006117085,
-0.004544782,
0.03492829,
0.008990261,
0.031115042,
0.033259995,
0.005435202,
-0.008109772,
0.022879487,
0.009049843,
0.0068916506,
0.0010484776,
0.015372154,
0.022177743,
0.014206995,
-0.00478311,
-0.024892034,
-0.04326977,
-0.017768675,
-0.007494091,
0.008506984,
0.018404216,
0.007050536,
0.0031181243,
0.0040813666,
-0.005408721,
-0.0019595856,
-0.0019115891,
0.010737999,
0.0036311916,
-0.019039758,
-0.00836796,
0.03739101,
-0.011605249,
0.0044256183,
-0.021396557,
0.018496899,
-0.006838689,
0.013035216,
-0.017768675,
-0.005653669,
-0.03018821,
-0.030320615,
0.0011568838,
-0.0049419953,
-0.03071783,
-0.018960316,
-0.016060658,
-0.01046657,
0.0011163349,
-0.014498285,
-0.012505598,
-0.0037106343,
-0.033922017,
-0.043190327,
0.00417736,
0.03492829,
0.018404216,
0.043508098,
-0.011479464,
-0.007586774,
0.037496936,
-0.011486084,
-0.012446017,
-0.023832798,
-0.036834914,
0.01910596,
0.011532426,
0.013611176,
-0.037788223,
0.009215348,
-0.010790961,
0.009936953,
-0.029367303,
0.019370768,
-0.0008614563,
-0.009764827,
0.0051008807,
0.03498125,
0.024402138,
0.021118507,
-0.015769368,
0.012949154,
-0.033577763,
-0.008030329,
-0.020218156,
-0.0137038585,
0.00027287725,
0.022429312,
-0.0015176858,
-0.0038364185,
-0.0056271884,
-0.0043494855,
-0.03167114,
0.0058787568,
0.016802123,
0.018404216,
0.015173548,
0.009162387,
0.018311534,
0.0044024475,
-0.016259264,
0.011214656,
-0.017848117,
0.03291574,
0.01343243,
-0.014816056,
0.001298391,
0.019238364,
-0.010857164,
-0.0019943418,
0.015411876,
-0.018642545,
0.042131092,
0.00097400014,
-0.039218195,
-0.008831375,
-0.008420922,
-0.029340822,
0.011433123,
-0.012829989,
-0.0033283164,
-0.012829989,
0.0035153376,
-0.016510833,
-0.0015814054,
0.039006345,
-0.04033039,
-0.0059615094,
0.008718832,
0.011201415,
0.022826524,
-0.0015466493,
-0.010718139,
-0.024150569,
-0.017464144,
-0.02183349,
-0.03106208,
0.001016204,
0.003374658,
0.023726875,
0.01852338,
0.035404947,
0.013339747,
-0.0056801504,
0.016073897,
-0.0021747428,
-0.0007348446,
0.00538555,
0.005200184,
-0.022733841,
0.04777152,
0.0009202108,
-0.014259958,
0.042581268,
-0.009301411,
0.03042654,
0.0286788,
-0.015981216,
-0.033551283,
-0.003043647,
-0.011095491,
-0.022151262,
0.014114313,
-0.0038761399,
-0.0012090179,
-0.02240283,
-0.0080435695,
0.024282973,
0.0050247484,
-0.008996882,
-0.017636271,
0.023356142,
-0.014101072,
0.020813977,
0.008851237,
0.02183349,
-0.02207182,
-0.019754741,
0.00046341552,
0.0015259611,
0.0036576726,
0.011750894,
0.009102805,
-0.013008735,
0.022349868,
-0.021343594,
-0.012042183,
-0.0054716133,
0.02423001,
-0.022641158,
-0.022296907,
-0.019820943,
-0.02686486,
-0.02658681,
-0.03016173,
-0.0080435695,
0.028890647,
-0.038900424,
0.023687154,
-0.007341826,
0.0041608093,
0.038158957,
0.004660636,
0.025474614,
-0.022058578,
-0.00808329,
0.010241483,
0.00056065,
-0.019900387,
-0.017967282,
0.003521958,
-0.0052167345,
0.024163809,
-0.010327546,
-0.021701086,
-0.0033051458,
0.016524073,
0.017384702,
-0.010433469,
-0.025818864,
0.025752662,
0.017477386,
0.0015135482,
-0.013717099,
-0.0112278955,
-0.006918132,
0.020112233,
-0.0056933905,
-0.0064348555,
-0.0032339783,
-0.016272506,
-0.019913627,
0.016881565,
0.012810129,
0.006772487,
0.016934527,
0.001943035,
0.0026513988,
-0.007586774,
0.00058340706,
0.015001423,
-0.024150569,
0.04120426,
-0.0066036712,
-0.00018184922,
0.0037238747,
0.022045339,
0.0019910317,
-0.0053822403,
-0.0008614563,
0.035643272,
-0.017106652,
-0.014829297,
0.017715713,
0.0056470493,
0.004683807,
-0.025845345,
-0.0073616863,
-0.01673592,
-0.0155045595,
0.004740079,
0.027301794,
0.003192602,
0.00089786755,
0.0021234362,
-0.010254723,
0.008189214,
-0.025898308,
0.019079478,
0.007321965,
-0.03911227,
0.004869173,
0.016855085,
0.0010973017,
0.015252991,
-0.013339747,
-0.011446363,
-0.0012446017,
0.02119795,
-0.02928786,
0.012995495,
0.021436278,
0.014710133,
-0.02477287,
0.00418398,
-0.0161401,
0.0027407717,
0.004567953,
-0.009950194,
-0.04152203,
0.011499325,
0.0006479542,
0.026176356,
0.014286438,
-0.009215348,
0.0041343286,
0.0071564596,
0.0053590694,
0.013889225,
-0.0161401,
-0.008546706,
-0.0035020972,
-0.007838342,
0.038132478,
-0.040197987,
-0.019291326,
0.0015549245,
-0.012393055,
0.012684344,
-0.014193756,
-0.016087139,
-0.011201415,
-0.012743927,
-0.010546013,
-0.01733174,
0.028546397,
-0.01345891,
-0.02654709,
0.013677378,
0.00075925665,
-0.003995304,
-0.011294099,
0.0028483504,
-0.0040383353,
-0.00957284,
-0.023899,
0.008123012,
-0.0014291403,
-0.019741502,
-0.042528305,
-0.001314114,
-0.041230742,
0.019595856,
0.015901772,
-0.022919208,
0.014048111,
0.0060376422,
-0.037576377,
-0.012306992,
-0.006749316,
-0.0023137676,
0.013035216,
0.026441166,
-0.018258572,
-0.009341133,
0.015769368,
0.025898308,
0.0039026206,
0.011750894,
0.014167274,
-0.018099686,
0.0101488,
-0.0005800969,
-0.030029325,
-0.022336628,
0.041627955,
-0.024693428,
-0.0038662094,
0.014829297,
-0.013809782,
0.006597051,
0.00088545465,
0.01848366,
0.011009429,
0.011214656,
0.01616658,
-0.019039758,
0.0043726563,
0.011923019,
-0.0008755243,
-0.008837996,
-0.0068585495,
0.0042601125,
0.011433123,
0.022230705,
-0.015703166,
-0.03280982,
0.021952655,
-0.014127553,
0.026745696,
0.007348446,
0.016034177,
-0.0026944303,
0.018258572,
-0.012969014,
-0.024587503,
0.0076264953,
-0.021727568,
0.007871443,
0.023448825,
0.008242176,
0.0012156382,
0.005137292,
0.022442551,
-0.027804932,
0.01314776,
0.00478311,
0.017596548,
-0.02119795,
0.0061601163,
-0.0032736997,
-0.045917857,
-0.00895716,
0.0040449556,
-0.007315345,
-0.014524766,
-0.013425809,
0.0056636,
-0.0064613363,
-0.012512219,
0.032147795,
-0.009519879,
-0.00037280124,
-0.026030712,
0.010254723,
-0.010056117,
0.0077191787,
0.17710418,
0.0019827564,
-0.010923366,
0.0042501823,
-0.007560293,
0.002331973,
0.022005618,
-0.0034259646,
-0.009480158,
0.020191677,
0.009036602,
0.0006686424,
-0.010585735,
-0.009930332,
-0.0029973055,
0.0036907736,
-0.01253208,
0.019264845,
-0.0058456557,
-0.0031859817,
0.022932447,
0.005799314,
0.012366574,
-0.0008804895,
0.029632112,
0.0030370266,
-0.009023362,
-0.017795157,
0.009056463,
0.02899657,
-0.005799314,
0.014882258,
0.0028268346,
0.017715713,
-0.0037271848,
-0.0009731726,
-0.013346367,
-0.011889918,
0.022932447,
0.0006777452,
0.014193756,
0.0032405986,
-0.010188521,
-0.0008738693,
-0.023170777,
0.022892727,
0.023091333,
-0.030082287,
-0.0047897305,
0.018933835,
-0.05134644,
-0.012902812,
0.0016186442,
0.01192964,
0.006775797,
-0.0034524456,
0.020721294,
0.03376313,
0.0074146483,
0.031300407,
-0.029949883,
0.0018553172,
-0.020840459,
0.02505092,
-0.01612686,
0.005527885,
-0.011903158,
-0.022879487,
0.019304566,
-0.01135368,
0.013809782,
-0.01760979,
-0.016828604,
0.00746761,
-0.020827217,
-0.0027689077,
0.02538193,
-0.0048791035,
0.018748468,
0.026043952,
0.013472151,
0.008937299,
-0.016378429,
-0.007196181,
-0.019450212,
-0.022482272,
0.038344324,
0.011585388,
-0.030638386,
0.0017063621,
0.008076671,
0.0024445169,
-0.018682266,
-0.013253684,
-0.008851237,
-0.030214692,
0.012644623,
0.00048948266,
-0.02870528,
-0.008156113,
-0.0140216295,
0.0800782,
0.027328275,
0.019926867,
-0.008751933,
-0.006007851,
0.010042876,
0.017490625,
0.01106239,
-0.02089342,
-0.0075933943,
-0.007686077,
-0.000011430227,
-0.012267271,
-0.019807704,
0.007348446,
-0.0042501823,
-0.019622337,
0.054868396,
0.007937646,
-0.013796542,
-0.011572148,
0.006517608,
0.0049419953,
0.0077456594,
0.002593472,
-0.020112233,
0.016100379,
0.0069710934,
-0.024984717,
0.00023315594,
-0.004121088,
0.008831375,
0.0024594124,
-0.0022591506,
0.0021846732,
-0.0059548896,
-0.011360301,
0.0022558405,
0.03225372,
-0.02302513,
-0.014418843,
0.033207033,
0.005398791,
0.0074146483,
-0.006729455,
0.0062561096,
0.024892034,
-0.012763787,
-0.0022012237,
0.0012793578,
0.002270736,
-0.0014994802,
0.004567953,
0.016497592,
-0.022230705,
-0.015491319,
-0.02654709,
-0.005848966,
-0.008321619,
-0.031115042,
-0.009506638,
0.0021284013,
-0.024918515,
-0.005276317,
-0.0085400855,
-0.16629997,
0.010042876,
0.011797235,
-0.02658681,
-0.0051538427,
0.00030597838,
0.013002115,
0.0068585495,
-0.037576377,
0.0024610674,
0.00863939,
-0.016246025,
-0.01941049,
-0.024905274,
0.019542895,
0.00078573753,
0.009526499,
0.008295137,
0.010638696,
0.036331777,
-0.009447056,
-0.03495477,
0.03937708,
0.006060813,
0.034239788,
0.0044024475,
-0.0039059308,
-0.0011204726,
-0.0070703966,
-0.03071783,
0.003939032,
0.0018486968,
0.02299865,
-0.010486431,
0.02629552,
-0.004932065,
-0.0013728684,
-0.006904891,
-0.0036080207,
0.03786767,
0.030373577,
0.013717099,
-0.0061932174,
0.014101072,
-0.012538699,
0.012618142,
-0.0021747428,
-0.01373034,
-0.021330355,
-0.011704552,
0.011605249,
-0.014961701,
-0.0064646467,
0.010956467,
0.02894361,
0.008791654,
0.01733174,
0.020165196,
-0.0066698734,
0.0070637767,
0.0009806204,
-0.005918478,
0.028043259,
0.0032124626,
-0.010532773,
-0.030055806,
0.003737115,
-0.00032190827,
-0.024415378,
0.0009500018,
-0.009486778,
-0.011631729,
-0.0030519222,
-0.027672527,
0.015517799,
0.021754049,
-0.017530346,
0.016100379,
-0.00985751,
0.015689926,
-0.01164497,
0.018549861,
-0.021423038,
-0.024084367,
-0.018735228,
-0.012009082,
0.017119894,
0.009308032,
0.012690965,
0.0120752845,
-0.00358816,
-0.02989692,
-0.006328932,
-0.0010923366,
0.017768675,
0.00507771,
0.012399675,
0.013889225,
0.0077257985,
0.008036949,
0.024322694,
0.0059581995,
-0.015200029,
0.016828604,
0.0037702161,
-0.013902466,
-0.0148690175,
0.011870057,
0.020151954,
-0.0023468686,
0.00895716,
-0.015107346,
0.01046657,
0.014418843,
-0.019172162,
0.0262558,
0.015041144,
-0.005829105,
0.0202976,
-0.018774949,
0.067155525,
-0.002686155,
0.003644432,
0.0128167495,
-0.0011626764,
-0.021621644,
-0.13473475,
-0.026176356,
0.004091297,
0.01553104,
-0.0051141214,
0.008242176,
0.010698278,
0.024640465,
-0.015570762,
0.02899657,
-0.0143394,
0.0013885915,
-0.0017030521,
-0.010380507,
-0.004144259,
-0.0012346713,
0.022826524,
0.007957506,
-0.03315407,
0.01910596,
-0.0032786648,
-0.006319002,
0.0037900768,
-0.0069446126,
0.013889225,
0.019953348,
-0.010837303,
0.027937336,
0.015742887,
0.0069247517,
0.0209199,
-0.0179408,
0.0012239135,
0.007798621,
-0.0026331933,
-0.021701086,
0.014008389,
0.0077191787,
0.028387511,
-0.03042654,
-0.010777721,
0.0013927291,
0.037205644,
0.026507368,
0.0023832798,
0.0006177494,
-0.013048457,
0.018417457,
0.013412569,
-0.039588924,
-0.05256456,
-0.014776335,
-0.015809089,
-0.00007152943,
0.006295831,
0.0029608943,
0.0033531422,
0.009870751,
-0.017252298,
0.0039489623,
0.009897231,
0.010618836,
-0.0060707433,
-0.01727878,
0.037576377,
-0.0035351983,
-0.03280982,
-0.057198714,
0.015425117,
-0.024971476,
0.0030684727,
0.03937708,
-0.005997921,
-0.0123599535,
-0.026811898,
0.0068122083,
-0.004872483,
-0.017080171,
0.020098994,
0.01821885,
-0.02955267,
-0.017305259,
0.023131054,
-0.0093874745,
-0.013359607,
-0.0066169114,
-0.0031396402,
-0.0037139445,
0.014074591,
-0.008725452,
-0.019767981,
-0.010314305,
0.01374358,
-0.013611176,
-0.027328275,
0.0030949537,
0.005461683,
0.016020937,
0.01971502,
0.028334549,
-0.020218156,
-0.026216079,
-0.02596451,
0.010843923,
0.0095596,
-0.0209199,
0.021462759,
-0.0042601125,
0.009950194,
-0.017172854,
-0.02117147,
-0.025699701,
-0.032412603,
-0.010340787,
0.005587467,
-0.015676685,
-0.036596585,
-0.024097607,
0.030585425,
-0.026970783,
0.002717601,
0.009394094,
-0.013849503,
0.007308725,
-0.004210461,
0.014789575,
-0.02117147,
-0.0009086254,
-0.016378429,
0.010969708,
-0.021330355,
-0.0015731301,
-0.005474923,
-0.034689963,
-0.007077017,
0.01611362,
-0.013849503,
-0.015809089,
0.004809591,
0.024335936,
0.017119894,
0.022972168,
-0.0191192,
-0.020774256,
0.018404216,
-0.03466348,
-0.0035186477,
-0.0144453235,
-0.03792063,
0.012220929,
0.002449482,
0.0053061075,
0.026123395,
0.017411184,
-0.009963433,
-0.018165888,
-0.011797235,
0.002204534,
0.00013674896,
-0.009632423,
-0.0010807512,
-0.011797235,
0.015888533,
0.0022790113,
0.0107313795,
-0.0041012275,
-0.018986795,
-0.0015027904,
-0.017080171,
0.0126049025,
0.0028516606,
-0.0061998377,
-0.010843923,
0.010287824,
0.031538736,
0.0053358986,
-0.018457178,
-0.0056271884,
-0.0046705664,
-0.014167274,
-0.009910472,
0.0065010577,
0.020284358,
-0.008447403,
-0.0038000073,
0.012882952,
0.03762934,
-0.0023634192,
-0.007229282,
0.023700394,
-0.009480158,
0.0161401,
0.020853698,
0.010393748,
0.009612562,
-0.0003214945,
0.022469033,
0.01698749,
-0.021661365,
-0.011525806,
0.02360771,
0.031565215,
0.0020175125,
0.025487853,
0.01314114,
-0.02178053,
0.00925507,
0.012664484,
-0.0490426,
-0.037576377,
-0.01137354,
0.016298985,
0.004998267,
0.001357973,
0.0067327656,
-0.011294099,
-0.03490181,
0.03556383,
-0.0014382432,
-0.019807704,
-0.016272506,
-0.0035087175,
0.021462759,
-0.011697932,
-0.0047566295,
0.00012237066,
0.024004923,
0.011989222,
0.02510388,
-0.008599668,
0.021568682,
-0.002898002,
0.016524073,
-0.009970054,
-0.023951963,
-0.0063024512,
-0.012796888,
-0.023395864,
-0.02208506,
0.025885066,
-0.009433816,
0.07324614,
0.017159615,
0.0033961737,
0.0114728445,
-0.00866587,
-0.00008275277,
0.00011099215,
0.015160307,
-0.004306454,
-0.035961043,
0.036278814,
-0.00865925,
0.03852969,
-0.041098338,
0.005908548,
0.0037834567,
-0.005855586,
0.045017507,
-0.0038926904,
-0.021581922,
0.01255194,
-0.015001423,
0.0049122046,
0.006027712,
-0.027540123,
0.0033845883,
0.021131748,
-0.012379815,
-0.0037073242,
-0.010777721,
-0.010387128,
0.003965513,
-0.03641122,
-0.008288518,
-0.010327546,
-0.017834878,
-0.025885066,
-0.02302513,
-0.027142908,
0.030241173,
-0.01255194,
0.010565874,
-0.0059681297,
-0.014696892,
-0.007043916,
-0.00039907524,
-0.02058889,
-0.024071125,
-0.043508098
] |
CONTEXT Many smokers are unable or unwilling to completely quit smoking. A proposed means of harm reduction is to reduce the number of cigarettes smoked per day. However, it is not clear whether this strategy decreases the risk for tobacco-related diseases. OBJECTIVE To assess the effects of smoking reduction on lung cancer incidence. DESIGN, SETTING, AND PARTICIPANTS Observational population-based cohort study with up to 31 years of follow-up from the Copenhagen Centre for Prospective Population Studies, which administrates data from 3 longitudinal studies conducted in Copenhagen and suburbs, the Copenhagen City Heart Study, the Copenhagen Male Study, and the Glostrup Population Studies, Denmark | [
-0.01946392,
-0.0062357867,
0.029275868,
-0.042420678,
-0.010951787,
0.0150378775,
-0.027916059,
0.0034595118,
-0.044926994,
0.009805283,
-0.016557664,
0.0047859913,
0.015277844,
0.024476545,
-0.0011831663,
0.01846406,
0.047326654,
-0.031168934,
0.004139416,
-0.0093520135,
-0.024129927,
0.010811808,
-0.008612118,
-0.0037861322,
-0.00063699344,
0.0034361817,
0.04140749,
-0.029329194,
-0.0041360827,
0.0042927274,
0.034288492,
0.009851943,
-0.014224659,
-0.007832228,
-0.021143682,
0.009578648,
-0.0029295865,
0.005355911,
0.007612259,
-0.040980883,
0.013071489,
0.0014306314,
-0.0048926426,
-0.0029679143,
-0.017504197,
0.01966389,
0.026556252,
-0.011911652,
-0.015597799,
0.01046519,
0.0105918385,
0.015584467,
-0.021050362,
0.016957607,
-0.016011074,
-0.008865415,
-0.0044793678,
0.030982293,
0.0032662055,
-0.028022712,
-0.001421466,
0.005589211,
-0.021330323,
0.0047060023,
-0.020983705,
0.0024729844,
-0.010951787,
0.03351527,
0.01263155,
0.01918396,
0.039994355,
0.03810129,
0.010425195,
-0.008298828,
0.008205509,
0.0071656555,
-0.010371869,
0.0082588345,
-0.006002486,
-0.006685723,
0.010558509,
-0.007852225,
-0.014677928,
0.05244593,
0.010218558,
0.023023417,
0.007005678,
0.01973055,
-0.002224686,
0.00015414492,
-0.008112188,
0.0064457566,
0.004962633,
0.009145376,
-0.018610707,
0.03223545,
-0.02002384,
0.0057791844,
-0.0052925865,
-0.034048527,
-0.005595877,
-0.017624179,
-0.001162336,
0.00020632504,
-0.016770966,
-0.011751675,
-0.011211751,
-0.02167694,
0.026142977,
-0.021823587,
-0.00091987016,
0.033035338,
-0.022436833,
-0.012678211,
0.016757635,
-0.022463497,
-0.015184524,
0.010071912,
0.0063391053,
-0.028049374,
0.022743456,
0.0063391053,
0.016024405,
-0.010558509,
0.018757353,
-0.01827742,
-0.04170078,
-0.0015739445,
-0.014264653,
-0.0072056497,
-0.013598081,
0.011631692,
0.029862452,
0.023463355,
-0.014464625,
0.020450447,
0.0051426073,
-0.0040760916,
-0.04519362,
-0.027222823,
-0.011465048,
0.008252169,
0.001428965,
-0.0062624495,
-0.010811808,
0.0356483,
0.035061717,
0.02874261,
-0.0041627456,
-0.013564752,
0.0003657817,
-0.029515835,
0.016850956,
0.001282319,
0.026742892,
0.00088320865,
0.005202599,
0.026649572,
-0.0113384,
0.000032964097,
0.0067890417,
-0.0257297,
0.004939303,
0.011285074,
0.007698913,
0.016117726,
0.016531,
0.011585032,
0.011398391,
0.008278832,
0.001943059,
0.046446778,
-0.02047711,
0.03012908,
-0.01918396,
0.012031635,
-0.01654433,
0.025983,
-0.001081514,
-0.02707618,
-0.033355292,
0.029755801,
0.036794808,
0.0071189953,
-0.020103829,
0.0059658247,
0.00016341443,
0.009998589,
-0.016970938,
-0.015477816,
-0.017650843,
0.022196867,
-0.021050362,
-0.025223106,
-0.6463088,
-0.0077855675,
-0.0024863158,
-0.0023063412,
0.027409464,
0.008298828,
0.027289482,
0.015691118,
-0.010271884,
0.029195879,
0.010251886,
0.0129915,
0.032608733,
-0.0011098434,
-0.018330745,
-0.02038379,
-0.013518092,
0.0045593563,
0.010431861,
-0.002016382,
-0.018250758,
0.018690696,
-0.0062657823,
0.019130632,
0.028582633,
0.02507646,
0.018690696,
-0.024356563,
0.021890244,
0.021050362,
-0.0054925582,
0.007918882,
0.019970514,
0.013638075,
0.049513012,
-0.02994244,
-0.016824292,
0.011891655,
0.020010509,
0.014171333,
-0.017397545,
-0.0009490327,
0.028555969,
-0.005035956,
-0.02746279,
-0.012918177,
0.021903574,
0.0021946903,
0.030235732,
-0.0038094623,
0.017944135,
0.008892078,
-0.010411864,
-0.0018564046,
0.028502643,
0.00093070196,
0.02682288,
-0.0057958486,
-0.0066323974,
0.007885554,
-0.010065246,
0.011451717,
-0.019970514,
-0.007458947,
-0.0037094764,
0.04316724,
-0.0054858923,
0.0134780975,
-0.006959018,
-0.017157579,
-0.006959018,
0.032395426,
-0.01773083,
-0.02387663,
0.021183677,
0.01893066,
0.024756506,
0.0015331169,
-0.025223106,
-0.0067990404,
0.01781082,
-0.0011223416,
-0.04031431,
0.01726423,
0.013644741,
-0.014517951,
-0.015731113,
-0.018077448,
-0.012164949,
0.013891373,
0.010805141,
-0.0067490474,
-0.00067198847,
-0.015917754,
-0.017584184,
0.027782746,
-0.014371305,
-0.0041860756,
-0.004669341,
-0.009738625,
-0.032502078,
-0.0073789586,
0.006685723,
-0.0049726316,
0.03170219,
0.00011446301,
-0.03452846,
-0.015824433,
0.02635628,
-0.010398532,
0.016877618,
-0.013311454,
0.000046113284,
-0.007105664,
-0.0013389777,
-0.025183111,
0.0172509,
-0.008412146,
0.007079001,
-0.04295394,
0.009938597,
0.008225505,
0.0070456723,
-0.010378535,
0.0014756251,
0.024956478,
-0.001996385,
0.008158849,
0.0023296713,
-0.029675812,
0.017677505,
-0.0017347551,
0.0102852145,
0.0006686556,
0.027116172,
-0.010391867,
-0.0054992237,
-0.0025713036,
-0.00486598,
-0.009272025,
-0.022423502,
-0.010991782,
0.007825562,
-0.010918459,
0.014611271,
-0.016864287,
-0.009925266,
0.0057991813,
-0.0013873042,
-0.010398532,
-0.0024513206,
-0.027569441,
0.009478662,
0.02836933,
-0.0059358287,
0.0038627882,
-0.0029512502,
-0.03122226,
-0.020490441,
-0.008618783,
0.006952352,
0.025196444,
-0.016131056,
-0.013904704,
-0.0023163396,
-0.01317814,
-0.0026279625,
0.009158707,
0.012344924,
-0.029809127,
-0.009098716,
-0.04180743,
-0.001834741,
0.01946392,
0.014344642,
-0.02250349,
-0.019063976,
0.004879311,
-0.013091486,
-0.0132447975,
0.004716001,
-0.027329477,
0.0040627597,
0.01670431,
0.018717358,
0.0101252375,
0.014904563,
0.004789324,
-0.0095119905,
0.028316004,
-0.002271346,
0.0128515195,
-0.0025613052,
0.024023276,
0.007138992,
0.0052425936,
0.017410876,
0.009245362,
0.0037494707,
0.01469126,
0.01846406,
-0.018850673,
0.015757775,
-0.020677082,
0.023663327,
-0.023103405,
-0.0033628587,
0.013144812,
0.0058291773,
-0.0016406018,
0.020610424,
-0.0040294314,
0.0011490044,
0.018477391,
-0.02323672,
0.030955631,
-0.0032995343,
-0.00890541,
-0.013631409,
-0.011591697,
-0.001043186,
-0.008672109,
0.014624602,
-0.008665443,
-0.027756082,
0.021663608,
-0.004895976,
0.011311737,
0.011265077,
-0.004066093,
-0.0060891407,
0.012604888,
-0.011018445,
0.0034111852,
-0.008198842,
0.018837342,
-0.0032612064,
-0.0222102,
0.016371023,
0.030369047,
-0.0017022598,
0.023516681,
0.017744163,
-0.009205367,
0.008392149,
-0.013071489,
0.028875925,
0.025849685,
0.0054925582,
0.019917188,
-0.0013098151,
0.022170205,
-0.01855738,
0.005105946,
-0.0018830675,
-0.029515835,
0.013231466,
0.02562305,
0.030182406,
0.028689284,
0.02167694,
0.007772236,
0.005489225,
-0.01249157,
0.003622822,
0.011305071,
-0.019850532,
-0.0076255905,
0.007212315,
-0.008698773,
-0.0020063834,
-0.0043427204,
-0.013584749,
-0.045780204,
0.019077307,
0.015344501,
0.0043627177,
0.006172462,
0.014704592,
0.020903716,
-0.010251886,
0.0050259572,
0.018517386,
0.030635675,
-0.015824433,
-0.024636522,
0.013544755,
-0.0048293183,
-0.0033945208,
0.005905833,
0.019957183,
0.032822035,
-0.01189832,
0.020050503,
0.0019263948,
-0.007698913,
0.016784297,
-0.0062124566,
0.012804859,
-0.0041660788,
-0.006499083,
-0.005955826,
-0.004312725,
-0.01542449,
0.024103265,
0.0050892816,
0.012358256,
-0.015371163,
-0.011791669,
-0.0003880702,
-0.0037894652,
-0.019997178,
0.004692671,
-0.0030262396,
0.01497122,
0.022610143,
-0.019717216,
-0.023823304,
0.030449037,
-0.023983281,
-0.0067723775,
-0.026516257,
-0.007072335,
-0.0017080923,
0.07534937,
0.00043910468,
-0.0034461801,
0.01001192,
0.008198842,
0.002916255,
0.026316285,
-0.04282062,
0.0042094057,
0.013511426,
-0.005125943,
0.0037894652,
0.01893066,
-0.0061424663,
0.022516822,
0.02636961,
-0.013384777,
-0.029169217,
-0.01197831,
-0.023863299,
-0.0020630423,
0.006422427,
0.008892078,
0.03938111,
0.00753227,
0.005175936,
0.029222542,
0.015624462,
0.014637934,
0.00088070903,
-0.0051226104,
0.016051067,
0.0047259997,
0.02700952,
-0.0050926143,
-0.0012156618,
0.009951929,
-0.012558227,
-0.0055792127,
0.0034361817,
0.013031494,
0.0068457006,
0.007278973,
0.023170063,
0.0073589613,
-0.008672109,
-0.0037361393,
0.016797628,
0.0075456016,
-0.033008676,
0.028449317,
-0.012198279,
-0.013291458,
-0.026622908,
0.036234885,
-0.0021830252,
0.01497122,
-0.012204944,
-0.002637961,
-0.01152504,
-0.02222353,
-0.017037595,
0.012464907,
-0.005129276,
-0.029515835,
-0.019530578,
-0.003502839,
-0.007965542,
-0.008785427,
-0.009458665,
-0.0005944994,
-0.019343937,
-0.009805283,
0.029249204,
0.013211468,
0.014211328,
0.02956916,
-0.0036394864,
-0.008645446,
0.016797628,
-0.016637651,
0.008892078,
-0.020957042,
-0.021237003,
0.00408609,
0.012831522,
-0.011231748,
-0.025303096,
-0.037328064,
0.026729561,
-0.000093892995,
-0.011198419,
0.006709053,
-0.043300554,
-0.013891373,
-0.010938456,
-0.00011914985,
0.0026346282,
-0.0112184165,
-0.023703322,
0.000037312442,
0.010898462,
-0.0075989272,
-0.016730972,
-0.009145376,
-0.009858608,
-0.00292792,
0.0060091517,
-0.0059025004,
-0.012424913,
0.024249911,
-0.034395147,
-0.0024996472,
0.0028745942,
0.020890385,
0.012424913,
-0.0015014547,
0.03076899,
0.013424772,
-0.0073589613,
-0.019223953,
0.009551985,
0.0017364216,
0.030262396,
-0.018864004,
-0.011345065,
-0.030529024,
-0.019850532,
-0.039007828,
-0.0060491464,
0.0061624637,
0.021463636,
0.005252592,
-0.051486067,
-0.022450164,
0.0039327783,
0.0070856665,
-0.0025479738,
-0.029035902,
-0.03242209,
-0.00048826443,
0.00002372061,
-0.008238837,
-0.014744585,
0.05391239,
-0.024103265,
0.005159272,
0.019423924,
-0.0054758936,
-0.008658778,
0.0049959617,
0.004352719,
-0.009531988,
-0.0028795935,
-0.00076030934,
-0.0347151,
0.0028096035,
-0.017610848,
0.013631409,
0.019850532,
0.037541367,
-0.022396838,
0.0057291915,
-0.004312725,
0.0008707104,
-0.0040627597,
0.018224094,
0.036074907,
-0.014944557,
0.016171051,
0.0070123435,
0.003344528,
-0.012064964,
0.013258128,
0.014917894,
-0.008485469,
-0.016784297,
-0.0033861888,
0.00096569705,
-0.016411018,
-0.010931791,
0.01046519,
-0.008692106,
-0.016144387,
-0.03279537,
-0.0006003319,
0.005619207,
0.011578366,
-0.004569355,
-0.00093070196,
0.0058625056,
-0.018344078,
-0.0060824747,
-0.0020413785,
0.011924984,
-0.0016497672,
-0.018170768,
-0.020637088,
-0.009978591,
0.013518092,
-0.004422709,
0.009618643,
0.006365768,
-0.012158284,
0.000082696664,
0.0063624354,
-0.020877054,
-0.0039794385,
-0.003162887,
-0.01707759,
0.003796131,
-0.0041460814,
-0.002116368,
0.0022913432,
0.009165373,
0.012064964,
-0.0090320585,
0.030955631,
-0.014064682,
-0.006079142,
-0.01773083,
-0.022810115,
0.029515835,
-0.01957057,
0.023156732,
0.011725011,
-0.01837074,
-0.022970092,
0.011651689,
0.022756789,
-0.005009293,
0.021970233,
0.015317838,
-0.011871657,
-0.0011131762,
-0.029169217,
0.010425195,
-0.024729842,
-0.022396838,
0.012031635,
0.029969104,
-0.0013764724,
-0.014771248,
-0.013824715,
-0.005982489,
-0.009845277,
0.010645164,
-0.008932073,
-0.0023263383,
-0.03407519,
-0.007838894,
0.021543626,
-0.012004972,
0.0041960743,
0.004699337,
-0.020543767,
-0.013598081,
-0.031275585,
-0.023450023,
0.018943993,
0.0023530012,
0.034048527,
-0.008732101,
-0.015851095,
0.002657958,
-0.014491288,
-0.011345065,
0.014171333,
-0.027889397,
0.03516837,
0.0010173564,
-0.018050786,
0.010138569,
-0.012271602,
0.009558651,
-0.0030495697,
-0.0035295018,
-0.014557946,
-0.0339952,
-0.0007207316,
0.02579636,
0.005912499,
-0.02406327,
0.006952352,
-0.013364781,
-0.012978168,
-0.013731395,
-0.019823868,
0.0160644,
-0.023849968,
0.0068390346,
0.001560613,
-0.0027446125,
0.02571637,
0.015651124,
-0.007958877,
0.00035349178,
0.032822035,
-0.039861042,
0.032395426,
0.006052479,
0.02515645,
-0.0006907358,
0.011698348,
-0.02772942,
-0.033355292,
0.008572123,
0.007932214,
-0.030955631,
-0.02874261,
-0.011398391,
-0.010365204,
-0.0002230935,
-0.015384495,
0.030449037,
0.0047359983,
0.013891373,
-0.019983847,
-0.027756082,
0.051859345,
-0.017984128,
0.027142836,
0.02442322,
-0.027489454,
0.0043327217,
-0.034288492,
0.013604746,
0.009005396,
-0.019530578,
-0.0007473945,
-0.033595257,
0.018730689,
-0.016584326,
0.0008327991,
-0.009831945,
0.0056692,
-0.010565176,
0.015571135,
-0.0011190088,
-0.002069708,
0.016864287,
-0.024543203,
-0.015011215,
-0.0065090815,
-0.02286344,
-0.006685723,
-0.009798617,
0.0065524084,
-0.03290202,
-0.010391867,
-0.006925689,
0.023863299,
0.010998447,
0.007905551,
-0.015451153,
-0.0062157894,
-0.03956775,
-0.009798617,
-0.0061557977,
0.0037028107,
-0.011904987,
0.016144387,
-0.013138145,
0.027702756,
-0.0119183175,
-0.0022313518,
-0.0347151,
-0.035834942,
0.00734563,
-0.02415659,
0.034928404,
0.0032695385,
-0.029435845,
0.026182972,
0.029222542,
-0.003379523,
-0.018530717,
0.020530436,
-0.011691683,
0.016011074,
-0.004962633,
-0.0038827853,
-0.020037172,
-0.011924984,
-0.037381392,
0.0107518155,
0.007805565,
0.02534309,
0.0039394437,
0.010478521,
-0.008878747,
-0.0115717,
0.009791952,
-0.008058863,
-0.007772236,
-0.026089652,
0.0021880246,
-0.0095853135,
-0.018610707,
0.021890244,
-0.0018947326,
0.020277139,
-0.0012048299,
-0.011038442,
0.002058043,
-0.006809039,
-0.009898603,
-0.026796218,
0.019423924,
-0.019370599,
0.0007194818,
0.010365204,
-0.02459653,
-0.006832369,
0.02011716,
-0.024129927,
-0.014797911,
-0.0050692847,
0.028529307,
0.0063890982,
-0.008665443,
0.01350476,
0.005275922,
-0.021250334,
0.012438244,
-0.022743456,
0.019290611,
-0.04271397,
0.014611271,
-0.004549358,
-0.009605311,
0.0075256047,
-0.009758622,
-0.0003445347,
0.01442463,
0.01497122,
0.19399929,
-0.010191895,
-0.00071864855,
0.039647736,
-0.022196867,
0.032582067,
0.033115327,
-0.004496032,
-0.0077522392,
0.03839458,
0.012291598,
-0.009398674,
-0.019717216,
0.011725011,
0.013091486,
-0.01442463,
-0.020223811,
-0.017210905,
0.0015289509,
0.017504197,
0.011964978,
0.008805424,
-0.0141046755,
-0.003796131,
0.010758482,
0.012824857,
-0.00977862,
-0.006172462,
0.026022993,
-0.004732665,
-0.019783875,
-0.0095853135,
0.015317838,
0.006645729,
-0.010178563,
-0.008598787,
0.00015008298,
-0.020170486,
0.013518092,
0.009878606,
0.0031412232,
-0.011138428,
-0.030315721,
-0.011971643,
-0.014651265,
0.017304225,
0.0010298546,
-0.010598504,
-0.00899873,
-0.02214354,
-0.035834942,
-0.00038015467,
0.024236578,
0.027489454,
-0.0009340348,
-0.017557522,
0.015251181,
-0.0041627456,
-0.013718064,
0.00085029664,
-0.011778338,
-0.010565176,
-0.0017947467,
0.0069390205,
-0.02029047,
0.008445474,
-0.03084898,
0.0058791703,
-0.016264372,
-0.008438809,
0.0011531706,
-0.025183111,
-0.049246382,
-0.00058491743,
-0.014437962,
-0.009938597,
0.023210058,
0.019997178,
0.022663468,
0.011911652,
-0.024409888,
-0.0076522534,
-0.012738202,
0.009771954,
-0.0015389494,
-0.016024405,
0.016171051,
0.016957607,
-0.024129927,
0.009272025,
-0.013278126,
0.001089013,
-0.014451293,
-0.004682672,
0.018144106,
0.005522554,
-0.009058721,
-0.009178705,
0.010911793,
0.006145799,
-0.028635958,
0.07454948,
-0.008738766,
0.017837482,
0.029915778,
0.014211328,
-0.017144246,
0.024276573,
0.008945404,
-0.006545743,
0.011398391,
-0.036128234,
0.013031494,
-0.01202497,
0.014957889,
0.0134047745,
0.016024405,
-0.030715665,
-0.0281027,
-0.015544472,
0.014637934,
-0.0049159727,
0.01837074,
0.030715665,
-0.009558651,
-0.01799746,
-0.025049798,
-0.010991782,
-0.014864569,
-0.01561113,
0.0203038,
-0.03020907,
-0.008478804,
-0.00013216885,
-0.0035628304,
-0.0009531988,
-0.0010906794,
-0.033781897,
0.014677928,
-0.000043900054,
-0.010198561,
-0.009405339,
0.0051626046,
0.013931367,
0.00649575,
-0.026662903,
0.006052479,
0.0017047594,
-0.0095119905,
0.0116116945,
-0.0024113264,
-0.0052692564,
0.005962492,
-0.020063834,
0.0045593563,
-0.007212315,
0.0056092083,
-0.01947725,
0.0011131762,
0.003001243,
-0.008578789,
-0.006769045,
0.0210237,
-0.016037736,
-0.011531706,
0.016864287,
-0.1692561,
0.019810537,
0.04167412,
-0.013024828,
0.01855738,
-0.0012256603,
0.016810961,
0.0314089,
-0.01763751,
-0.0063291066,
0.02707618,
0.017384212,
-0.01845073,
-0.021130351,
0.004159413,
-0.0066923886,
-0.0026812882,
0.037434716,
0.017224235,
0.017517528,
0.011445051,
0.0056325383,
-0.008445474,
0.009065387,
-0.010478521,
0.0045160293,
-0.013311454,
-0.0089587355,
-0.0075722644,
-0.008825421,
-0.018810678,
0.014651265,
0.016317697,
-0.007898885,
-0.0033495273,
0.0134780975,
-0.01414467,
-0.007238978,
-0.0022880104,
0.0087987585,
0.036768142,
0.038767863,
-0.0057691857,
0.008712104,
-0.026756223,
0.007538936,
0.028582633,
0.005619207,
0.018584043,
-0.007238978,
0.023476686,
-0.031275585,
0.011205086,
0.0060658106,
-0.007845559,
-0.001193165,
-0.003962774,
-0.010065246,
0.0010940123,
-0.0065690726,
-0.010858468,
-0.014837906,
-0.0030245732,
0.0072323126,
0.004929304,
-0.0380213,
-0.016091062,
-0.008652112,
-0.0067757103,
0.004106087,
-0.015557804,
-0.011365063,
0.009198702,
0.0041127526,
0.012658213,
0.018610707,
-0.0071523236,
-0.00081946765,
0.014837906,
-0.009478662,
0.015277844,
0.0024513206,
-0.021930238,
0.022023559,
-0.01414467,
0.003669482,
0.002776275,
0.005379241,
-0.004239402,
-0.011858326,
0.015717782,
-0.020330464,
0.0026179638,
-0.029169217,
0.00008488385,
0.0148779005,
-0.0073722927,
-0.018170768,
0.0066757244,
-0.012551562,
-0.0014148003,
-0.023036748,
-0.03690146,
0.006629064,
0.03820794,
-0.008065528,
-0.011785003,
-0.010118572,
0.026476262,
-0.0074056215,
-0.011171756,
0.006439091,
0.0066590603,
0.0133914435,
0.0084188115,
0.010491853,
0.009385342,
-0.01533117,
-0.018050786,
-0.020517103,
0.052579246,
-0.008238837,
0.012518233,
0.008805424,
0.0008548793,
-0.01893066,
-0.10819806,
-0.025996331,
0.012478239,
0.016197713,
-0.017144246,
0.040447623,
-0.024743175,
0.013891373,
0.011791669,
0.008898744,
-0.009412005,
0.0019797205,
-0.019957183,
0.0017730831,
0.06393764,
-0.033675246,
0.008985398,
-0.037488043,
-0.0040494283,
0.03423517,
-0.0019330605,
-0.024223248,
0.0111450935,
-0.023996612,
-0.0117583405,
-0.022463497,
-0.0082588345,
0.023596669,
0.018344078,
0.00585584,
0.001657266,
0.0055025565,
-0.0032778706,
0.0072989697,
-0.0123115955,
-0.012044966,
0.0052392604,
-0.033728573,
0.045940183,
-0.028342666,
0.016464343,
0.010525181,
0.02139698,
-0.0048259855,
0.004722667,
-0.03692812,
-0.020010509,
0.025956336,
0.012771531,
0.0018614039,
-0.0030379046,
-0.033488605,
0.009318685,
-0.0073789586,
0.016637651,
-0.019783875,
0.014171333,
0.0013256462,
-0.03020907,
0.014544614,
-0.000020934545,
0.017930802,
-0.011358397,
0.015997741,
0.016357692,
-0.04647344,
-0.006422427,
0.0018630704,
0.0055492166,
-0.008612118,
-0.010078577,
-0.0067723775,
-0.0038461238,
0.01289818,
-0.01790414,
-0.0020797064,
-0.0264496,
-0.012698208,
-0.006545743,
-0.027222823,
0.0068723634,
-0.009005396,
-0.004402712,
-0.023130069,
-0.00045868524,
0.008378818,
0.01386471,
0.0059658247,
-0.00067407155,
-0.013278126,
-0.01221161,
0.024076601,
-0.011958312,
-0.028662622,
0.01294484,
0.007178987,
-0.010485187,
-0.0010290215,
0.019530578,
0.02534309,
-0.036794808,
-0.015277844,
-0.057111938,
0.0056458698,
0.02038379,
-0.004369383,
-0.0037094764,
-0.0048826444,
0.03178218,
-0.0003441181,
0.0052859206,
0.009751957,
0.0011456716,
0.03663483,
-0.03084898,
-0.008092191,
-0.0010423529,
-0.007592262,
0.019370599,
0.029969104,
0.033968538,
0.039861042,
0.015997741,
-0.01707759,
0.015117866,
0.0144112995,
0.005569214,
-0.00486598,
0.0087987585,
0.015677787,
-0.01166502,
0.005159272,
0.007492276,
-0.015811102,
0.0043660505,
-0.003092897,
0.022930097,
-0.009598645,
0.007872222,
0.0042194044,
0.010605169,
0.012544896,
-0.0031812177,
-0.016784297,
0.013311454,
0.0037094764,
-0.012231607,
-0.0026446267,
-0.03914114,
0.0214903,
0.016411018,
0.0052925865,
0.011725011,
-0.008392149,
0.011984975,
-0.01957057,
-0.017344218,
-0.0017597516,
0.023636663,
0.009538653,
-0.036074907,
-0.033541933,
0.020343795,
0.030715665,
0.008185511,
-0.0032112135,
0.004639345,
-0.027236156,
0.010305212,
-0.001993052,
-0.030902306,
-0.009958594,
0.0055492166,
-0.019170627,
0.004252733,
0.009711962,
-0.012158284,
-0.01643768,
-0.009272025,
-0.0017480867,
-0.024409888,
0.006832369,
0.02836933,
-0.015091203,
-0.018677363,
-0.005732524,
0.039781053,
0.040021017,
-0.018810678,
0.015771108,
0.013891373,
-0.0001693511,
-0.0028845929,
0.015091203,
0.011005113,
-0.013784721,
0.0070523378,
0.036501516,
0.036314875,
-0.022610143,
-0.0053392462,
0.011811666,
0.011931649,
0.0177175,
-0.027889397,
-0.016757635,
-0.011125096,
-0.0023063412,
0.00026621242,
-0.03562164,
-0.013038159,
0.025409747,
0.028236015,
0.006585737,
0.0006536577,
-0.001263155,
0.0042993934,
0.027236156,
0.0046760067,
0.0057025286,
-0.018117443,
0.0415408,
-0.019037314,
0.02167694,
0.02404994,
-0.0082655,
0.024143258,
-0.0025246437,
0.014944557,
-0.023689989,
0.03570163,
-0.003549499,
0.018330745,
0.0034728432,
-0.026756223,
0.0070190094,
0.003552832,
-0.021063693,
0.033355292,
-0.0035128375,
-0.026209634,
0.06180461,
0.0036361534,
-0.047886573,
-0.013851378,
0.008132186,
0.030315721,
-0.0024196585,
0.026409606,
0.0003168303,
-0.033808563,
-0.0049593,
-0.00055867113,
0.0028329336,
-0.043860476,
-0.02643627,
0.017210905,
0.0009648638,
0.015171192,
-0.01197831,
-0.008398814,
0.0207704,
-0.007492276,
-0.002537975,
-0.00429606,
-0.03508838,
-0.030049091,
0.024129927,
-0.013731395,
-0.018784015,
0.0010023585,
-0.006299111,
0.01579777,
-0.022730125,
-0.018197432,
0.022063553,
-0.0060258163,
0.022236861,
-0.007905551,
0.007845559,
0.011485046,
0.01166502,
0.010578507,
-0.042287365,
-0.043673836,
-0.03460845,
-0.008152183,
0.0098919375,
-0.011798334,
-0.0065024155
] |
Three macromolecular crystallography (MX) beamlines at the Helmholtz-Zentrum Berlin (HZB) are available for the regional, national and international structural biology user community. The state-of-the-art synchrotron beamlines for MX BL14.1, BL14.2 and BL14.3 are located within the low-β section of the BESSY II electron storage ring. All beamlines are fed from a superconducting 7 T wavelength-shifter insertion device. BL14.1 and BL14.2 are energy tunable in the range 5-16 keV, | [
-0.019883275,
-0.015059839,
-0.021772454,
-0.035505846,
-0.015086636,
0.029851709,
-0.0070073805,
-0.012326558,
0.0018489837,
-0.0009462643,
0.004404735,
-0.00087173557,
0.011067105,
-0.014121949,
-0.008963551,
-0.0033328603,
0.0073758373,
0.013150562,
-0.004575565,
-0.0046057114,
-0.024318157,
-0.010578062,
0.009298513,
-0.015301011,
-0.010015328,
0.0162523,
0.02119632,
-0.014028159,
-0.018771205,
0.014510503,
-0.0011606392,
0.0065116384,
-0.013157262,
0.0008503818,
-0.0010902975,
0.002659589,
0.009332009,
0.0070944703,
0.025108663,
-0.0072217556,
0.028243897,
0.009854548,
0.0024787101,
0.014470307,
0.0104909735,
0.005412967,
0.010008629,
0.0035438854,
-0.023996593,
-0.0016371211,
0.012949586,
0.019092767,
-0.005888611,
0.009171227,
-0.0016639179,
-0.02488089,
0.019293744,
0.0047229477,
-0.01351232,
-0.0061163846,
-0.010651754,
-0.011361871,
-0.03823913,
0.014738277,
-0.006190076,
-0.021330304,
-0.009800954,
0.023675032,
-0.022683548,
-0.020137845,
0.026475303,
0.016962416,
-0.0072217556,
-0.0050847055,
0.026220733,
-0.009164528,
0.010678551,
-0.0060594412,
0.008467809,
0.013867378,
0.030200068,
-0.002555751,
-0.0074227317,
0.015528784,
0.018262064,
0.015957534,
-0.010745543,
0.019709095,
-0.01162314,
-0.0021738957,
0.029851709,
0.027319405,
0.016198706,
-0.0008960202,
-0.011348473,
-0.007945271,
0.0024435392,
0.03719405,
-0.018985579,
-0.007188259,
-0.0050210627,
-0.009043942,
-0.016305894,
-0.021303508,
-0.040999204,
-0.019655501,
-0.023956398,
-0.008052458,
0.02257636,
-0.00914443,
-0.023728624,
0.028270693,
-0.009050641,
-0.022335188,
0.012326558,
-0.014443511,
0.029208584,
-0.022777336,
0.02129011,
0.0076639038,
0.014309526,
0.030173272,
0.005855115,
-0.020633588,
0.024813898,
0.015689565,
-0.022522766,
-0.022522766,
-0.0033027136,
0.00036322314,
0.010866129,
0.0024837344,
0.014604292,
0.0032273475,
-0.0068399,
0.0031184852,
-0.008762575,
-0.019266946,
-0.00037955248,
-0.035747018,
0.011241285,
0.025858976,
-0.014349721,
-0.0102632,
0.0034333484,
0.035747018,
0.0005229576,
0.0008692233,
0.0068566483,
-0.0038654478,
0.0027165322,
-0.018931985,
0.014443511,
-0.0022006927,
0.0049808673,
0.022294993,
-0.015863745,
0.03325491,
-0.02248257,
-0.019816283,
-0.02162507,
-0.010283297,
0.016855229,
-0.0038888953,
0.027761552,
0.012152378,
-0.0020332122,
-0.017069604,
0.008407516,
-0.004736346,
0.0037984557,
0.042473033,
-0.028887022,
0.017819915,
-0.010236403,
0.0059656524,
0.034755535,
0.014041558,
-0.025416827,
-0.0031352334,
-0.009003747,
-0.012762007,
0.015890542,
0.0055770976,
-0.025966164,
0.027949132,
0.008494606,
-0.012018395,
0.023889406,
-0.0393378,
0.0088563645,
-0.00067871436,
0.029101396,
-0.025966164,
-0.6499848,
-0.023031907,
-0.02000386,
-0.022589758,
-0.010926422,
0.02300511,
0.01136857,
0.0014378193,
-0.021424094,
0.024854094,
-0.016198706,
-0.00023384452,
-0.011254684,
-0.025269445,
-0.026823662,
-0.02607335,
-0.01761894,
0.0009697116,
0.015930736,
-0.012741909,
-0.020365618,
-0.004207108,
-0.03306733,
0.0170964,
0.012199273,
-0.0145373,
0.018570228,
-0.020472806,
-0.0030749403,
0.002539003,
-0.019883275,
0.029932098,
-0.011361871,
-0.010075621,
0.040838424,
0.023983195,
-0.0042941975,
0.019963665,
0.039846938,
0.017310776,
-0.013646304,
-0.0042774496,
0.022254797,
-0.0019092767,
-0.014456909,
0.0324778,
0.0072217556,
-0.0020482854,
0.003624276,
-0.0057914727,
-0.008936754,
-0.0132041555,
-0.0029191836,
0.01976269,
0.006431248,
0.01949472,
0.017551947,
-0.005201942,
-0.015635971,
0.010745543,
0.0017987397,
0.021611672,
-0.01674804,
-0.026435109,
-0.014564097,
-0.0065484843,
-0.015193823,
-0.0012150704,
0.021223119,
0.018784603,
0.028458271,
0.020285228,
-0.010825934,
-0.006303963,
0.002967753,
0.0282171,
0.010980016,
-0.0072016576,
-0.00786488,
0.0126749175,
0.012601227,
-0.007884977,
-0.021424094,
0.00684325,
0.029932098,
-0.00367787,
-0.007295447,
0.0060326443,
0.021785852,
-0.005191893,
0.030200068,
-0.01547519,
-0.0052588847,
-0.029288974,
-0.012922789,
0.023527648,
0.016279096,
0.030869989,
0.02171886,
-0.013639605,
-0.015743159,
0.004488475,
0.01674804,
-0.012460543,
0.0027734756,
0.008655388,
-0.031647097,
-0.013492222,
0.03641694,
-0.014671284,
-0.022562962,
-0.0006468931,
-0.035854205,
-0.00401618,
0.015783355,
-0.03941819,
0.018074486,
0.018931985,
-0.01590394,
-0.026100148,
0.019025775,
0.0045856135,
0.012762007,
-0.012949586,
0.0032507947,
0.0248005,
0.025430227,
-0.038265925,
-0.013800386,
0.010792438,
0.01299648,
0.007275349,
0.031191552,
-0.012916089,
0.029717725,
0.02488089,
0.0170964,
-0.012962984,
-0.005121551,
-0.015662769,
-0.044777565,
-0.009285114,
-0.006421199,
-0.008286931,
-0.016493471,
-0.021357102,
-0.028913818,
0.015635971,
-0.0019812933,
-0.020513,
0.0051014535,
0.0077777905,
-0.0009697116,
0.015180425,
0.009265017,
-0.021692064,
-0.024465539,
-0.028699443,
-0.006729363,
-0.015488588,
-0.009358806,
0.0088898605,
-0.012440445,
0.013947769,
0.00564409,
-0.011931305,
0.020754173,
0.032799363,
-0.00083237764,
-0.03360327,
-0.0065049394,
0.000970549,
-0.037971158,
0.0045956625,
-0.028002724,
0.014523901,
0.0039424887,
0.00051458355,
-0.0038152037,
-0.021209719,
0.010229704,
0.037676394,
-0.0018791303,
-0.0057914727,
0.010169411,
0.026743272,
0.02154468,
-0.003001249,
-0.0034182752,
0.015528784,
0.0003680382,
0.023045305,
-0.029690927,
0.014001362,
-0.016935619,
-0.0010300046,
-0.005111502,
-0.0010936471,
-0.0010006955,
0.020070853,
0.019387532,
0.016453275,
0.035693426,
-0.012668218,
0.009439196,
-0.03470194,
0.003607528,
-0.027172022,
0.013987964,
0.015930736,
0.012065289,
-0.03539866,
-0.0052521857,
0.011536051,
0.01949472,
0.008695583,
0.008648689,
0.021678664,
-0.01436312,
-0.009479391,
0.0063475077,
-0.01043068,
0.037167255,
0.009713864,
0.004555467,
-0.0046291584,
0.017458158,
0.040731236,
0.012205972,
0.023125695,
-0.011475758,
-0.0026461906,
-0.0016228852,
-0.0014679658,
0.008045759,
0.018931985,
0.013961167,
-0.005660838,
0.02752038,
0.011917906,
0.007764392,
0.024894288,
0.0035673329,
0.007905075,
0.011924605,
-0.010973317,
0.021772454,
0.0026545646,
-0.0006703404,
0.008936754,
-0.035773817,
0.004438231,
-0.019534916,
-0.0153412055,
-0.00812615,
-0.0035773816,
0.010423981,
-0.006113035,
0.0016965766,
0.001368315,
-0.0057445783,
0.022120813,
0.011569547,
-0.0004193291,
-0.0137333935,
-0.013646304,
-0.0023966448,
-0.0064345975,
-0.036818895,
-0.018918587,
0.010477575,
0.0060560917,
-0.002351425,
-0.011442262,
0.03727444,
-0.00496077,
-0.001838935,
-0.00004985159,
0.013230952,
0.03657772,
-0.00846111,
-0.0367653,
0.0014562422,
0.010779039,
0.00009426007,
-0.012420347,
-0.016573861,
0.004669354,
0.0012117208,
-0.0020901556,
0.014845463,
-0.0037113659,
-0.0047731916,
0.0056574885,
-0.016520267,
-0.014604292,
0.0022877825,
-0.030923583,
0.011951402,
-0.0011321676,
-0.010042125,
-0.0041903597,
0.010926422,
-0.017163392,
0.0126749175,
0.0027316054,
0.012011695,
-0.0021789202,
0.015769955,
-0.019079369,
-0.009827751,
-0.013398433,
-0.020044055,
-0.0078112865,
-0.017659135,
0.011301578,
-0.012078688,
0.0057881232,
0.020365618,
-0.019186556,
-0.020754173,
-0.020057455,
-0.009003747,
-0.002239213,
0.01957511,
0.020111049,
-0.027426593,
0.0020884806,
0.009760759,
0.01941433,
-0.009666969,
-0.030843193,
0.0022325139,
-0.006642273,
-0.00966027,
0.007456228,
-0.0013666402,
0.00914443,
-0.011261383,
-0.0014713154,
0.015850347,
-0.022415578,
0.010913024,
0.0014671284,
0.0023564494,
-0.013867378,
0.0056809355,
0.05104803,
0.013532417,
-0.0013867378,
-0.0029627285,
0.0063374587,
0.009043942,
-0.040811628,
0.005915408,
-0.00070006814,
0.019119564,
0.023139093,
-0.0044583287,
-0.02257636,
-0.011536051,
-0.0077241967,
0.019950267,
-0.005667537,
0.001778642,
0.025724992,
0.0042607016,
0.015006245,
-0.024653116,
-0.008065857,
-0.0019176507,
0.011167594,
-0.005563699,
0.011804019,
0.030816397,
-0.020245032,
0.0028957364,
-0.03368366,
-0.009204724,
-0.019173158,
-0.00786488,
-0.01820847,
-0.018503236,
-0.027413193,
0.0038587486,
-0.0376228,
0.012098785,
0.0068131033,
-0.007918474,
-0.01325105,
-0.013318042,
-0.009874645,
-0.015354604,
-0.02324628,
-0.004140116,
-0.011335074,
-0.030682411,
0.0042171567,
0.03411241,
0.0032608437,
0.014550698,
0.0009387277,
0.0011162569,
0.029101396,
-0.046304986,
0.0042339046,
0.004950721,
-0.01615851,
-0.010919723,
0.030066084,
0.020499602,
-0.026354717,
-0.024666514,
0.005875213,
-0.012969683,
-0.007764392,
0.020204837,
-0.012326558,
-0.008501306,
0.01240025,
0.011857613,
0.025577608,
-0.015944134,
-0.01359271,
0.003155331,
-0.027734756,
0.004009481,
-0.002172221,
0.00074612524,
0.006454695,
-0.0051851934,
0.006712615,
-0.0162389,
-0.0031570059,
-0.008628591,
-0.019896673,
0.023795618,
0.021156125,
0.016828433,
0.0012862496,
0.004046327,
0.015287612,
0.0006184214,
-0.01606472,
0.014657886,
-0.034916315,
0.0324778,
-0.012098785,
-0.029396161,
0.027319405,
0.009519586,
-0.013465425,
-0.009017145,
0.012962984,
-0.013786987,
0.037596002,
-0.014470307,
-0.03754241,
-0.01803429,
-0.011743726,
-0.011321676,
0.025430227,
-0.008561599,
-0.017310776,
-0.019213352,
0.03496991,
-0.009733962,
0.0007750156,
-0.03274577,
-0.02778835,
-0.027815146,
0.014215738,
-0.035773817,
-0.0009797604,
-0.011777222,
0.0008022312,
-0.012420347,
-0.019534916,
-0.010564664,
-0.0170964,
-0.023192687,
0.0029342568,
0.021571478,
0.043652095,
0.023996593,
0.0052387873,
0.0033462585,
0.032370616,
-0.00082442234,
0.0040664244,
-0.008099353,
0.031834677,
-0.03606858,
0.024304757,
0.009385603,
-0.0035639831,
0.006200125,
-0.008534802,
0.000102581755,
0.02685046,
-0.008313728,
-0.0067528104,
0.01128818,
-0.038105145,
-0.008528102,
0.0019444476,
-0.005704383,
-0.012842398,
-0.033040535,
-0.0013708272,
0.017632337,
-0.0022794085,
0.017846713,
0.0041736118,
0.017431362,
-0.005754627,
0.029824913,
0.0058082207,
0.011656636,
-0.015769955,
-0.009184626,
-0.021772454,
-0.0032809412,
0.040248893,
0.016212104,
-0.008307029,
-0.007858181,
-0.015501987,
0.0145373,
-0.009526286,
-0.0043243445,
0.00376161,
-0.022442374,
-0.006102986,
-0.019789485,
-0.023474054,
-0.014389917,
-0.032933347,
0.023969797,
0.0088965595,
-0.011402067,
0.014188941,
-0.011522653,
-0.0074227317,
0.037729986,
-0.0026562393,
0.03531827,
-0.005332576,
0.030789599,
0.028485069,
-0.0026244181,
-0.02181265,
-0.033335302,
0.006223572,
-0.016359488,
0.027547179,
0.030468037,
-0.019106165,
-0.016319292,
0.005583797,
0.0025724992,
-0.005121551,
-0.044295218,
0.013137164,
0.013123765,
0.019829681,
-0.017994095,
0.008186443,
-0.013646304,
0.018355854,
-0.017940503,
0.007998864,
-0.01317066,
-0.0050847055,
-0.013840581,
0.024813898,
0.0021772454,
0.034460768,
0.009968434,
-0.0038788463,
0.008789372,
0.0014897382,
-0.012246167,
0.010872829,
-0.013552515,
0.04172272,
-0.018248666,
-0.0031653799,
0.001991342,
0.007576814,
-0.021450892,
-0.021249915,
0.0060560917,
0.033656865,
-0.005881912,
0.005439764,
-0.003872147,
-0.003805155,
0.02786874,
-0.012494039,
0.0027734756,
-0.004354491,
-0.0018741058,
0.00829363,
0.029181788,
0.02685046,
-0.011214488,
-0.025162257,
-0.0029778017,
-0.0027550529,
-0.022187805,
0.0010417282,
-0.0021186273,
-0.057934824,
-0.0057814238,
0.012902691,
0.01727058,
0.028887022,
-0.0018841546,
0.0039960826,
-0.018235268,
0.026381515,
-0.007844782,
0.015301011,
0.048368342,
0.009606676,
-0.017431362,
-0.01162314,
-0.01897218,
-0.006190076,
-0.0066288747,
0.003624276,
-0.0089032585,
-0.008501306,
0.00418701,
0.022361984,
0.03215624,
-0.026301123,
0.0073155444,
0.00030020863,
0.029128194,
0.00060251076,
-0.006648972,
0.031271942,
-0.022455774,
0.015100034,
-0.014175542,
-0.023045305,
-0.0170964,
0.009620075,
-0.016439877,
-0.014724878,
-0.0071346657,
-0.008139548,
0.009593278,
0.022120813,
0.014832065,
0.009104235,
0.0099483365,
-0.0025071818,
-0.026381515,
0.01752515,
0.0016505194,
0.017806517,
0.00041200183,
0.0055536507,
0.033656865,
0.024465539,
-0.030655615,
-0.0014696406,
0.007925173,
-0.028538663,
-0.031754285,
-0.019722493,
-0.01590394,
0.023715226,
0.016547065,
-0.021611672,
0.0050981035,
-0.016520267,
-0.033388894,
-0.0037582605,
0.004743045,
0.0058685136,
0.021531282,
0.032531396,
0.009640172,
0.025349835,
0.019441126,
0.0213705,
-0.007295447,
-0.0153278075,
0.013853979,
0.0016136738,
0.027078234,
0.015434994,
-0.0265021,
0.0035539344,
0.032879755,
-0.018878393,
-0.028538663,
0.03349608,
-0.0012535909,
-0.0058785626,
0.031352334,
0.0089032585,
-0.009687067,
0.007576814,
0.013961167,
-0.027707959,
0.00015219783,
0.003949188,
-0.010109117,
-0.0033814295,
0.0021387248,
0.011777222,
-0.0062905643,
0.00521869,
-0.0017149994,
-0.02198683,
0.01803429,
-0.028163506,
-0.0018741058,
0.019548314,
0.021142727,
0.011569547,
0.031218348,
0.013565914,
0.0066824686,
0.0022710343,
-0.020914953,
-0.0058852616,
0.023755422,
-0.0054163164,
0.0020951799,
-0.0051516974,
-0.015555581,
-0.016935619,
0.010008629,
-0.019159758,
-0.011482457,
-0.02547042,
0.007335642,
0.019025775,
-0.023996593,
-0.0196689,
-0.00023614737,
-0.030307256,
0.022161009,
0.014001362,
0.012875894,
-0.016882025,
0.0017769672,
-0.0008466135,
-0.026100148,
-0.01761894,
-0.0034735438,
-0.002018139,
0.011415465,
-0.0005036973,
0.18832837,
-0.007992165,
-0.01068525,
0.042258658,
-0.0019009027,
-0.022294993,
-0.0036979674,
0.009090837,
-0.0049473713,
0.013244351,
0.011529352,
0.0063743046,
-0.035613034,
-0.00066992163,
0.00018778742,
-0.0004547093,
-0.038426705,
-0.01786011,
-0.0083539225,
0.025457023,
0.012279664,
-0.000613397,
0.014416714,
-0.015997728,
0.010162711,
-0.00066740945,
-0.035371862,
-0.008106052,
0.011750426,
0.021665266,
-0.000090910464,
0.011261383,
0.007958669,
0.009807653,
-0.008132849,
-0.013572613,
-0.0162389,
-0.017752923,
0.016547065,
0.047403656,
-0.03255819,
0.015917338,
-0.013693199,
-0.011073804,
0.010805836,
-0.003222323,
-0.009787555,
-0.0011346798,
-0.00028492606,
-0.004820086,
-0.022294993,
0.0121054845,
0.019883275,
0.030736005,
0.008802771,
-0.0040496765,
0.010330192,
0.017042806,
0.0034149257,
0.011730328,
-0.009204724,
-0.001880805,
-0.018355854,
0.034326784,
-0.0067662084,
0.017216986,
-0.007677302,
0.015823549,
0.016962416,
0.0035974793,
-0.021424094,
0.012031793,
-0.008186443,
-0.012828999,
-0.014966049,
-0.0013080221,
0.03531827,
0.006136482,
0.016801635,
0.0121188825,
-0.006139832,
-0.008394118,
0.0045621665,
0.001299648,
0.012025094,
0.0021437493,
0.021584876,
0.012272964,
-0.0062905643,
-0.015207222,
0.013920972,
-0.003728114,
0.0019863178,
0.011053707,
0.009077438,
-0.00598575,
-0.00079971895,
-0.001039216,
-0.022428976,
-0.006447996,
-0.015033042,
0.05616623,
0.0035304872,
-0.011683433,
-0.01504644,
0.009204724,
-0.0049909162,
0.011073804,
0.0012854121,
0.021343704,
0.0017602191,
-0.031995457,
0.007905075,
-0.011402067,
0.0027048087,
0.026301123,
-0.0061163846,
-0.04199069,
0.041883502,
-0.008487907,
-0.0077241967,
-0.011676734,
0.01906597,
0.029449755,
-0.0014512178,
-0.01658726,
-0.013827183,
0.00012540095,
-0.013840581,
-0.009767458,
-0.0003427068,
0.015796753,
0.040892016,
-0.005747928,
0.0012217696,
0.007576814,
-0.013961167,
-0.021410696,
-0.016828433,
-0.005557,
-0.0015785029,
-0.006779607,
-0.002239213,
-0.018664017,
0.009265017,
-0.021142727,
0.011227887,
0.006779607,
-0.01906597,
-0.03976655,
-0.01351232,
-0.009311911,
-0.015247417,
-0.03044124,
0.029851709,
-0.01761894,
-0.020231634,
-0.026863858,
-0.0023464006,
0.021785852,
-0.016145112,
0.0023330022,
0.033924833,
-0.02966413,
-0.0075969114,
-0.0069269896,
-0.17085682,
0.011696832,
0.014925854,
-0.044589985,
0.014403315,
0.010470876,
0.018945385,
0.013143863,
-0.011234586,
0.022629954,
-0.002855541,
-0.006806404,
-0.05686295,
-0.026435109,
-0.006987283,
-0.0039022935,
-0.014925854,
0.021866243,
0.01812808,
0.008018962,
0.008541501,
-0.021249915,
0.028511865,
0.00376161,
0.009023844,
0.022254797,
-0.0026260929,
0.011938004,
0.012741909,
-0.017766323,
-0.019280344,
-0.015260815,
0.04515272,
-0.022053821,
0.04180311,
-0.0010928097,
-0.0057010334,
0.00564409,
-0.01873101,
0.011509254,
0.016171908,
0.008822868,
-0.01479187,
-0.014456909,
-0.007871579,
0.026863858,
0.009251618,
-0.027239013,
0.004726297,
-0.013150562,
0.008146247,
-0.014430112,
0.027654367,
0.024907688,
0.027439991,
0.011743726,
-0.006404451,
0.021008743,
-0.00461911,
-0.01188441,
-0.0009889718,
-0.012299761,
0.004150165,
-0.04737686,
-0.025631202,
-0.0015659418,
0.0076907007,
-0.008789372,
-0.035532646,
0.002574174,
-0.014068355,
-0.0056574885,
-0.0025373283,
-0.025845578,
0.021357102,
0.014202339,
0.004284149,
-0.0051516974,
0.010812535,
-0.015555581,
-0.0039190417,
0.03888225,
-0.010022027,
-0.016573861,
-0.009251618,
-0.0142693315,
-0.022281595,
0.009814352,
0.0115829455,
0.016346088,
-0.0020683832,
-0.009043942,
0.0074093333,
-0.009385603,
-0.0016354462,
0.010209606,
0.004719598,
0.0047731916,
-0.01984308,
0.0075902124,
0.02522925,
0.018195072,
-0.018342454,
0.016989212,
0.015542182,
0.012199273,
-0.023366867,
0.026810264,
0.038855456,
-0.002666288,
-0.0026110196,
0.0029359316,
0.027841944,
0.03572022,
0.011737027,
0.01769933,
-0.0064613945,
0.0019143011,
0.0094324965,
-0.015059839,
0.031111162,
0.0056474395,
-0.038453504,
0.008983649,
-0.030226864,
-0.017511752,
-0.10697309,
-0.009017145,
-0.0005497545,
0.020539798,
0.0026947598,
0.020834563,
0.010223004,
0.019963665,
-0.015662769,
0.031781085,
-0.010109117,
0.00025122063,
-0.010008629,
0.005979051,
0.010712047,
-0.008193142,
0.015917338,
-0.0011438912,
-0.010464177,
0.02522925,
0.0009990206,
0.014497104,
-0.018851595,
-0.005155047,
0.01240025,
-0.0030816395,
-0.028860224,
0.013545816,
0.023380265,
0.0032893154,
-0.001693227,
-0.01820847,
-0.015260815,
-0.004267401,
-0.0028689394,
0.0031235097,
0.004732996,
-0.035747018,
0.014925854,
-0.0063140118,
-0.011616441,
0.022201203,
0.025604405,
-0.016681049,
-0.0019796186,
0.001103696,
-0.016774839,
0.001380876,
0.002599296,
-0.0041669128,
-0.024894288,
0.0037046666,
-0.03789077,
-0.017123198,
0.0026461906,
-0.017766323,
-0.017846713,
-0.011830816,
-0.020070853,
-0.02402339,
-0.004002782,
0.026904054,
-0.005171795,
0.023460656,
0.0011673385,
-0.0142827295,
-0.024130577,
-0.004438231,
-0.0008089304,
-0.030682411,
-0.012165777,
0.032209832,
-0.0046827523,
0.006833201,
-0.026193937,
-0.0021085783,
-0.039552175,
-0.023969797,
0.01873101,
-0.0076572043,
-0.01830226,
-0.0230855,
0.036470536,
0.0026796865,
-0.008762575,
0.0028856874,
0.005456512,
0.0029828262,
0.02488089,
-0.026917452,
0.0170964,
0.052950606,
0.00538617,
-0.010129215,
-0.00983445,
0.014443511,
-0.02300511,
-0.029369365,
0.01359271,
0.011743726,
-0.044831157,
-0.042553425,
-0.070850916,
0.036631316,
0.018610423,
-0.014738277,
-0.015877143,
-0.009184626,
0.018878393,
-0.0019946918,
0.003011298,
0.0006586167,
-0.009995231,
0.004625809,
-0.007248552,
-0.017578743,
-0.024130577,
-0.015716363,
0.011495856,
-0.017391166,
0.016734643,
0.02591257,
-0.016453275,
0.0016304218,
0.009037243,
0.014939253,
-0.038667876,
-0.0045186216,
-0.012875894,
0.0153278075,
-0.023353469,
-0.010899625,
0.022187805,
-0.020365618,
-0.020124447,
0.036792096,
-0.010926422,
-0.035613034,
0.0032005506,
0.022294993,
0.02068718,
0.030789599,
-0.016212104,
-0.028860224,
0.008233337,
0.007637107,
0.011301578,
-0.012366754,
0.008668786,
-0.003351283,
-0.0054699103,
0.0018138129,
0.034085613,
0.013653004,
0.021477688,
-0.04386647,
-0.0075902124,
0.026368117,
-0.020312024,
0.0022877825,
0.0051885433,
-0.0017451459,
0.018422846,
0.028485069,
0.001359941,
0.005335926,
-0.0025674747,
-0.02497468,
-0.008615192,
-0.009271716,
-0.0036477235,
-0.046867717,
-0.025858976,
0.009847849,
0.02608675,
0.029932098,
-0.020713978,
-0.0076840012,
-0.00914443,
0.011569547,
-0.006906892,
-0.013565914,
0.016131714,
-0.021316906,
0.009090837,
-0.0170964,
0.01043738,
0.002555751,
-0.014376518,
0.010698649,
-0.0067059156,
-0.014430112,
0.012989781,
0.025457023,
0.008936754,
0.012031793,
0.014724878,
0.021263313,
0.007938571,
-0.025202453,
0.016225502,
0.020539798,
-0.025698194,
0.024733508,
0.0126414215,
-0.01906597,
-0.023018507,
0.025711592,
-0.018704213,
-0.0077509936,
0.0089032585,
0.0089099575,
-0.016305894,
0.0072619505,
0.008059157,
0.0075969114,
-0.0036443737,
0.016935619,
0.0012242818,
0.0020834564,
-0.0037482115,
0.027239013,
0.0076572043,
0.017216986,
0.004290848,
0.016319292,
-0.0027667764,
0.00052212016,
0.015702963,
-0.014590894,
-0.0110403085,
-0.00906404,
0.01376019,
-0.0094190985,
-0.011381969,
-0.012547633,
-0.011850914,
0.0016128364,
-0.011629839,
-0.0069202906,
0.005523504,
0.10064903,
0.01273521,
0.0063542067,
0.016131714,
-0.027252413,
0.02616714,
0.008816169,
0.024465539,
0.0032725672,
-0.042044282,
-0.0003286803,
-0.017779721,
0.0088831615,
-0.021852843,
-0.014014761,
-0.005071307,
-0.014175542,
0.0030297206,
-0.022670148,
-0.01146236,
0.024572726,
-0.031111162,
0.02411718,
0.003771659,
-0.0018506586,
-0.0058350177,
0.027319405,
0.0032708924,
0.012855796,
-0.029047802,
-0.00047731918,
-0.0072887475,
-0.04694811,
-0.018690813,
0.0126548195,
-0.01213898,
-0.029476553,
0.00069797464,
0.008796072,
0.011428864,
-0.023098899,
0.008769275,
0.012527535,
-0.019333938,
0.013867378,
-0.010892926,
-0.00011660824,
-0.0066221757,
-0.017873509
] |
Macromolecular X-ray crystallography is routinely applied to understand biological processes at a molecular level. However, significant time and effort are still required to solve and complete many of these structures because of the need for manual interpretation of complex numerical data using many software packages and the repeated use of interactive three-dimensional graphics. PHENIX has been developed to provide a comprehensive system for macromolecular crystallographic structure solution with an emphasis on the automation of all procedures. This has relied on the development of algorithms that minimize or eliminate subjective input, the development of algorithms that automate procedures that are traditionally performed by hand and, finally, the development of | [
-0.017738627,
-0.010934588,
-0.004411264,
-0.017217297,
0.00018902433,
0.025451656,
0.0040503424,
-0.011943831,
-0.011028159,
-0.014757683,
0.007746447,
0.011696533,
0.0096379435,
0.0021688715,
-0.011930464,
-0.0017795439,
0.016268207,
-0.011823524,
-0.018112916,
-0.013581346,
-0.011014792,
0.022096422,
-0.017270766,
-0.030103534,
-0.0015848802,
0.0328305,
0.013728388,
-0.04058363,
-0.0013743426,
-0.0004624308,
0.00546061,
-0.002003449,
-0.010660554,
-0.004364478,
-0.00025460846,
0.009350543,
0.00426088,
0.018072814,
-0.014998297,
-0.015145339,
0.03545052,
-0.012552051,
0.007312004,
0.020866616,
-0.00020876223,
-0.014182881,
0.011181885,
-0.002431208,
-0.027162692,
-0.001593235,
-0.009544371,
0.023526741,
-0.014303189,
-0.014116044,
-0.009718148,
-0.015025032,
0.0037194975,
-0.0053703794,
0.009617892,
-0.011382397,
-0.010553614,
-0.00042462593,
-0.020585898,
0.002904082,
0.0010393205,
-0.013080066,
-0.0025364768,
0.009497585,
0.0009708122,
-0.021775603,
0.027670655,
0.018754555,
-0.0057446687,
0.026427481,
0.006509956,
-0.003059479,
-0.01682964,
-0.0054472424,
-0.002456272,
0.019382827,
0.0036225833,
0.0014353317,
0.010186009,
0.004481443,
0.01767179,
-0.0019750432,
-0.0052199955,
0.013033279,
-0.003756258,
-0.013848695,
0.024836753,
0.023700519,
-0.007906856,
0.003485567,
-0.011716585,
-0.0013166955,
0.025130836,
0.026507685,
-0.009664678,
-0.026053192,
-0.02970251,
0.013160271,
-0.015760243,
-0.012846136,
-0.029248016,
0.0007022097,
0.01221118,
-0.016535556,
0.011415816,
0.002003449,
-0.01226465,
0.04742777,
0.007365474,
-0.03392663,
0.022671223,
-0.022938572,
0.037054617,
-0.03502276,
0.019115476,
0.014396762,
-0.00060905516,
0.00095577387,
0.007866754,
0.008922784,
0.030157004,
0.004608434,
-0.02964904,
-0.010540247,
0.00027528626,
-0.002656784,
0.0043811873,
0.008394768,
0.010132539,
0.0043811873,
-0.027189426,
0.014597273,
0.0068976125,
0.014958194,
-0.02200285,
-0.03507623,
0.015426056,
0.03646645,
-0.009664678,
0.002753698,
-0.009945395,
0.02817862,
0.009123296,
0.004083761,
0.022791531,
-0.010841015,
0.020037832,
-0.024916958,
0.030290678,
0.02137458,
-0.006413042,
0.013621449,
-0.01371502,
0.02986292,
-0.019422928,
-0.008982938,
-0.008789109,
0.0061490345,
-0.009323807,
-0.016254839,
0.016254839,
0.026868608,
0.005891711,
-0.013207057,
0.0024646267,
0.002103705,
-0.0050462186,
0.026400747,
-0.0075793536,
0.021936012,
0.017738627,
-0.0038264373,
0.025932884,
0.010887802,
-0.018179754,
-0.009778301,
0.00021931,
-0.00063203054,
-0.0030962394,
0.0037529161,
-0.022323668,
0.021641929,
0.02015814,
0.008147471,
0.020478958,
-0.018955067,
0.021655295,
0.00245293,
-0.008749006,
-0.011121732,
-0.6407829,
-0.015760243,
-0.010847699,
-0.041706495,
-0.00796701,
0.03242947,
-0.015693406,
-0.009330492,
-0.009671362,
0.020398753,
-0.010132539,
-0.0021120596,
0.00875569,
-0.030664967,
-0.005915104,
-0.040476687,
-0.0015339168,
-0.030932317,
0.0044714175,
0.00049626717,
-0.037215028,
-0.004578357,
-0.019529868,
0.0040637096,
0.0011237026,
-0.018981801,
0.019596705,
-0.02343317,
0.01376849,
0.02579921,
-0.007733079,
0.011021476,
-0.027095854,
-0.009738199,
0.050341878,
-0.0046886387,
-0.012364906,
0.047187157,
0.0551809,
0.009156714,
0.002334294,
-0.0014929789,
0.010353102,
0.019489765,
-0.022978675,
0.010914536,
0.0031396837,
-0.010339735,
-0.003281713,
0.0047721853,
-0.018166387,
-0.014316556,
-0.0006679556,
-0.017912405,
0.011843575,
0.008548494,
0.02748351,
-0.027363203,
0.009764934,
-0.020171506,
-0.005236705,
0.012846136,
-0.013494457,
-0.031894773,
-0.008214308,
0.02263112,
-0.020412121,
0.0032482943,
-0.0028740054,
0.0071048085,
0.045609795,
0.027242897,
-0.008154155,
-0.009557738,
-0.024261951,
0.025972987,
0.015385954,
0.008274462,
-0.0019717014,
0.023820825,
0.0022925204,
-0.016294941,
-0.044326518,
0.0047153737,
0.036894206,
-0.00091817783,
-0.009945395,
-0.012338172,
0.015426056,
-0.0065734517,
0.010279582,
-0.019650176,
-0.0028890437,
-0.044406723,
-0.01582708,
0.012879554,
-0.030210475,
-0.005978599,
0.022016218,
-0.026173498,
-0.015198809,
-0.007719712,
-0.016014224,
-0.0014278125,
0.027202794,
0.016228104,
0.0048022624,
0.0065166396,
0.056624588,
-0.008087317,
0.0017051874,
-0.0046451944,
-0.013641499,
-0.021829072,
0.023125717,
-0.031360075,
0.009604525,
-0.0103130005,
-0.03750911,
-0.03587828,
0.014797785,
-0.002932488,
0.008327931,
-0.028820258,
0.019516502,
0.015238912,
0.015372586,
-0.032509677,
-0.00857523,
-0.0055474984,
-0.0027119247,
-0.005834899,
0.013741755,
-0.017137092,
0.0086554345,
0.015907286,
0.017070254,
-0.0076261396,
-0.025598697,
-0.02764392,
-0.021040391,
-0.008401453,
-0.0038364627,
0.020759676,
-0.014209617,
-0.019436296,
-0.028633112,
0.010446675,
0.022056319,
0.0011353992,
-0.0007936933,
-0.0030177056,
0.006663682,
0.030825377,
0.0000739388,
-0.0034454644,
-0.0005894217,
-0.024449095,
-0.004732083,
-0.013086749,
-0.0053971144,
0.009738199,
-0.024034705,
0.0058282153,
0.0038631978,
-0.026922077,
0.016963314,
0.016909845,
-0.01888823,
-0.04542265,
0.011970566,
-0.009450799,
-0.047668386,
0.012879554,
-0.033284992,
0.036707062,
-0.0011813499,
0.00032854726,
0.0120708225,
-0.006991185,
0.020184875,
0.002606656,
-0.0005108878,
-0.014517069,
-0.0013384175,
0.021334477,
0.033258256,
0.004006898,
0.0031196324,
0.020759676,
0.0074456786,
0.014730948,
-0.0016859717,
0.010333052,
-0.0016467047,
0.004982723,
0.0041739913,
0.010520196,
-0.007098125,
0.038765654,
0.014730948,
-0.004885809,
0.020746307,
-0.011897045,
0.015131972,
-0.030798642,
0.018914964,
-0.011021476,
-0.00010892397,
0.0024144987,
-0.014503701,
-0.016548924,
-0.026387379,
-0.027256263,
0.015546364,
0.009965446,
0.018420368,
0.026200235,
-0.021281006,
-0.0010201047,
-0.011709901,
-0.011482653,
0.053683747,
0.0037696254,
0.0041673076,
-0.0023626997,
0.025090734,
0.023660416,
0.011783422,
-0.0028121807,
-0.008715588,
0.012933023,
-0.024021337,
-0.002855625,
0.026948811,
0.023713885,
0.0064464607,
-0.023379698,
0.021708766,
0.005303542,
0.0015238911,
0.0068107243,
0.032482944,
0.0030745172,
0.006840801,
-0.0063929907,
0.022978675,
0.021534989,
0.0039233514,
0.008581913,
-0.023860928,
0.0054138238,
-0.0020903375,
-0.0076729255,
0.012491898,
0.016843008,
0.031787835,
0.023633681,
0.05657112,
0.017698525,
-0.01645535,
0.016709333,
-0.00060738425,
-0.0039500864,
-0.009771618,
0.012311436,
0.003833121,
-0.020746307,
-0.029007401,
0.004057026,
-0.023192555,
-0.010246163,
0.016896477,
0.01009912,
0.020585898,
-0.024342157,
-0.0021354528,
0.0100256,
0.020545796,
0.010573666,
-0.034220714,
-0.017471278,
0.009270338,
0.020799778,
0.017110357,
-0.023098981,
-0.00601536,
0.007064706,
-0.0033602468,
-0.009631259,
0.008662119,
-0.026133396,
0.0058549503,
0.0066068703,
-0.050208203,
-0.022163259,
0.027617186,
-0.021695398,
-0.012846136,
-0.00307953,
0.015078502,
-0.0046218014,
0.020505693,
-0.024810018,
0.047909,
-0.0017945823,
0.0103130005,
-0.033472136,
0.013180322,
0.00052885036,
-0.017337603,
-0.009744883,
0.006062146,
-0.025932884,
-0.023874294,
-0.0073988927,
-0.014423496,
0.015559731,
0.022417242,
-0.014463599,
-0.0005505725,
-0.021294374,
-0.003478883,
0.02236377,
0.03967464,
0.019035272,
-0.007706344,
0.007906856,
-0.01041994,
0.024221849,
-0.012679041,
-0.026534421,
0.02526451,
-0.0062292395,
-0.016401881,
0.0042642215,
-0.00013304806,
0.024716444,
0.012779298,
0.030932317,
0.0085551785,
-0.009778301,
-0.017551484,
-0.0017962533,
-0.012879554,
-0.009838455,
0.04135894,
-0.00426088,
0.0051698675,
-0.0063161277,
0.0089161005,
0.0142363515,
0.0024245242,
-0.028820258,
-0.0016700978,
0.018286694,
0.0045950664,
0.008902732,
-0.02083988,
-0.01398237,
0.00701792,
-0.0028105099,
-0.0035691136,
0.012959759,
-0.0058482666,
0.009978814,
0.018594146,
-0.00030431873,
-0.010560298,
-0.0028272192,
0.01063382,
0.0079335915,
-0.021428049,
-0.018540677,
0.006005334,
0.0018864836,
-0.005230021,
-0.013153587,
-0.026026458,
-0.0056678057,
-0.01777873,
-0.02791127,
-0.005687857,
-0.022136524,
-0.0075325673,
-0.027122589,
0.0048657577,
-0.014383393,
0.0001121614,
0.0123782735,
-0.005276807,
-0.0121710785,
-0.034167245,
-0.0023810798,
0.020759676,
-0.033525605,
-0.011576226,
-0.006690417,
0.012518632,
0.01582708,
0.012338172,
0.0014035839,
-0.0010877775,
0.02780433,
-0.02574574,
-0.01641525,
0.0082945125,
-0.03804381,
-0.005707908,
0.031039257,
0.007639507,
-0.03218886,
-0.0015155365,
0.010145907,
0.000034645756,
-0.001704352,
0.005266782,
0.011596277,
-0.0016784525,
0.01609443,
-0.009805037,
0.027202794,
0.0026551129,
-0.038525037,
0.009230236,
-0.022296933,
-0.016615761,
-0.01989079,
0.0020569188,
-0.008314564,
-0.012565418,
0.0017477962,
-0.0075793536,
-0.027202794,
-0.0033669306,
-0.015479526,
0.011716585,
0.017417809,
0.016896477,
0.011148467,
0.00018547359,
0.023713885,
0.026788402,
0.004110496,
0.001113677,
-0.026146764,
0.020452224,
0.008829212,
-0.030370884,
0.023165818,
-0.009464166,
-0.01704352,
0.0064163837,
-0.009116612,
-0.020171506,
0.034915823,
-0.008107368,
-0.025050633,
-0.014249719,
0.0039467444,
-0.032563146,
0.0071449107,
-0.023647048,
-0.009704781,
0.007840019,
0.02368715,
0.003485567,
0.023486638,
-0.009584473,
-0.032055184,
-0.017444544,
0.0124785295,
-0.008261094,
0.023887662,
-0.023379698,
0.00701792,
-0.00896957,
-0.018326797,
-0.015867183,
-0.03897953,
-0.0026434164,
0.0019867397,
0.02590615,
0.034461327,
0.03847157,
-0.002832232,
-0.017123725,
0.022484079,
0.0033719435,
-0.002232367,
0.00091316504,
-0.0037662836,
-0.047989205,
0.008909416,
0.017524749,
0.003179786,
-0.012445111,
-0.04975371,
0.016254839,
0.011850259,
0.0024094859,
-0.031012522,
0.008281145,
-0.030638233,
-0.012438428,
0.020545796,
-0.004808946,
0.0010234467,
-0.021922644,
0.0094842175,
0.015412688,
-0.006215872,
0.01482452,
0.011135099,
-0.00050128,
-0.025759108,
-0.0030494533,
0.0047721853,
0.018126285,
-0.015760243,
-0.0038164116,
-0.029354956,
0.009657995,
0.019703645,
0.025104102,
0.008722272,
0.028526174,
-0.004718716,
0.0024445753,
-0.007438995,
-0.004184017,
-0.01962344,
-0.0037529161,
-0.022510814,
-0.0084482385,
-0.013634816,
-0.002178897,
-0.030424353,
0.0064965887,
0.0045850407,
-0.0014712567,
0.01682964,
-0.0066235797,
-0.011957198,
0.04114506,
-0.02986292,
0.013300629,
-0.016923212,
0.034728676,
0.034889087,
-0.0032633326,
-0.02801821,
-0.025625434,
0.014797785,
0.007138227,
0.022831632,
0.01815302,
-0.011101681,
-0.018701086,
-0.013995737,
-0.009404013,
-0.017056886,
-0.06870878,
-0.0063161277,
0.0033502213,
0.023366332,
-0.023553476,
0.014690845,
-0.023272758,
0.023620313,
-0.024930324,
0.0063228114,
-0.011288825,
-0.026775034,
-0.0025581988,
0.01645535,
-0.0104667265,
0.015345851,
0.016294941,
-0.0034621737,
0.017698525,
0.0063228114,
-0.008347983,
0.019436296,
-0.0025431605,
0.022029584,
0.0017828859,
-0.0096914135,
-0.011883678,
0.028445968,
0.003000996,
-0.016228104,
-0.008882681,
0.040904447,
-0.009718148,
-0.02141468,
0.005306884,
0.014717581,
0.007084757,
0.011008109,
0.00016061847,
-0.026654728,
-0.016268207,
0.016174635,
0.0074991486,
-0.006834117,
-0.0019884107,
-0.022978675,
0.010914536,
0.0026250363,
0.0028756761,
0.0054004565,
-0.005808164,
-0.034167245,
-0.021668663,
0.009744883,
0.02257765,
0.036814,
-0.0019733722,
-0.003104594,
-0.007739763,
0.027938005,
-0.00535367,
0.012471846,
0.02796474,
0.00282889,
-0.044647336,
-0.0008229347,
-0.025411554,
-0.028873727,
0.018874863,
-0.01967691,
-0.030798642,
-0.017858936,
0.0028138517,
0.024435729,
0.0000704925,
-0.01847384,
0.012679041,
0.0056978827,
0.022497445,
-0.0016383501,
-0.013354098,
0.009571106,
-0.014837888,
0.005788113,
-0.0031213034,
-0.035691135,
-0.010333052,
0.0069978684,
-0.009190133,
-0.0009265325,
-0.013614764,
-0.016081061,
-0.01208419,
0.019503133,
-0.0028105099,
0.004311008,
-0.00991866,
-0.008067266,
-0.0051230816,
0.027884535,
-0.0183669,
0.021708766,
0.007365474,
-0.011028159,
-0.007565986,
-0.0048523904,
-0.047614913,
0.0018430394,
0.011482653,
-0.022858368,
-0.036065426,
-0.014276454,
-0.038311157,
0.03486235,
0.034648474,
-0.028472703,
-0.0038932746,
-0.008187573,
-0.046759397,
-0.021361211,
-0.0074991486,
0.0028639797,
0.013955635,
0.005587601,
0.021214169,
0.033846423,
-0.028793523,
0.004561648,
-0.00041877766,
-0.008073949,
0.012151027,
-0.0050562443,
0.036707062,
0.002225683,
-0.016843008,
0.008060582,
0.017417809,
-0.0113957655,
-0.025839312,
0.010994741,
-0.0029491973,
0.007692977,
0.020585898,
0.0030979104,
0.015800346,
0.030558027,
0.031012522,
-0.015786977,
0.008301197,
0.036386244,
-0.023553476,
-0.013942268,
-0.0077999164,
0.008027163,
-0.005808164,
0.0025882756,
0.017137092,
-0.004628485,
0.0066202376,
-0.008374718,
0.007719712,
0.021334477,
-0.00009665305,
0.015238912,
0.011903728,
0.010934588,
0.012244599,
0.0014027485,
-0.0200512,
-0.018246591,
-0.0053202515,
0.000059474783,
0.002178897,
-0.025839312,
0.020104669,
-0.02021161,
0.009952079,
-0.010012233,
0.0040269494,
-0.012485214,
0.012592154,
0.023205921,
0.021869175,
-0.0072050644,
-0.003006009,
-0.04205405,
0.008855946,
0.02384756,
0.015212176,
-0.030210475,
0.02321929,
-0.009604525,
-0.01348109,
-0.004230803,
0.010968006,
0.0150651345,
0.00094240636,
0.015907286,
0.19463031,
-0.009150031,
0.0024211823,
0.045930613,
0.013006545,
-0.02669483,
0.013334048,
-0.00307953,
-0.0013868746,
-0.0072986367,
0.022176627,
0.016081061,
-0.057266224,
0.0003220724,
0.0143432915,
-0.0067071263,
-0.011415816,
-0.018808026,
-0.017658424,
0.021561723,
0.028312294,
-0.0003333512,
0.0037763093,
0.003156393,
0.04309671,
-0.009885241,
-0.019970994,
0.006640289,
0.009624576,
0.006489905,
-0.0002907424,
0.00338364,
0.01274588,
0.012799349,
-0.010587033,
0.006118958,
-0.0042508543,
0.006309444,
-0.001077752,
0.010988058,
-0.034327652,
-0.011629696,
0.01419625,
-0.015666671,
0.030370884,
-0.011930464,
-0.006703784,
-0.020973554,
-0.0072585344,
-0.0028155225,
-0.037829928,
0.015332484,
-0.00047788693,
0.04039648,
-0.011248723,
-0.021107228,
-0.031146197,
-0.0010059018,
0.00470869,
-0.0040269494,
-0.013527876,
-0.0068006986,
-0.008254411,
0.017444544,
-0.016642496,
0.012411692,
-0.010480094,
0.033846423,
0.008822528,
-0.0072317994,
-0.022083055,
0.036626857,
-0.01487799,
-0.00144118,
-0.0172574,
-0.013554611,
0.028633112,
0.028472703,
0.022203362,
0.013447671,
-0.019984363,
-0.0026400746,
-0.020986922,
-0.003980163,
-0.020037832,
-0.010841015,
0.03456827,
-0.0018831418,
-0.0041439147,
-0.021655295,
0.0024880196,
0.0038130698,
-0.01693658,
-0.022711325,
0.0063161277,
-0.0014027485,
0.0013793554,
0.014075942,
-0.021829072,
-0.0003734536,
-0.037829928,
0.05903073,
-0.017030152,
0.03529011,
-0.004030291,
-0.0014745987,
-0.028659848,
0.017604953,
0.0018363557,
0.015532996,
0.0025264511,
-0.03218886,
0.0028004842,
-0.015212176,
0.001641692,
0.02126764,
0.007164962,
-0.05312231,
0.026320541,
0.0075860373,
0.0011211962,
-0.0120173525,
0.006018702,
0.019650176,
-0.0041171797,
-0.029167812,
-0.008728956,
0.003407033,
0.003579139,
-0.0066202376,
-0.012505265,
0.010974689,
0.006262658,
0.0000867841,
0.0143432915,
-0.018086182,
0.0006278532,
0.000963293,
-0.023312861,
0.008601964,
-0.013681602,
0.0037462325,
-0.008087317,
0.025465023,
0.021829072,
0.0047989204,
-0.012358222,
0.023553476,
-0.022069687,
-0.00646317,
0.0030461114,
-0.009116612,
0.0010668909,
-0.011001425,
0.015613201,
-0.010640503,
-0.016575659,
0.004247512,
0.004137231,
0.0025999723,
-0.010861066,
-0.0096379435,
0.021641929,
-0.0053503285,
0.006312786,
0.009150031,
-0.1687509,
-0.006242607,
0.001665085,
-0.02780433,
0.020358652,
0.005417166,
0.034728676,
0.011282141,
-0.010600401,
-0.001727745,
0.007639507,
0.00020583809,
-0.03435439,
-0.023941131,
0.016375147,
0.008374718,
-0.004130547,
0.01809955,
0.020879982,
-0.0032349268,
0.0038398048,
-0.009063142,
0.017324237,
-0.010566982,
0.012846136,
0.024101542,
0.008742323,
-0.006957766,
-0.008949519,
-0.036840737,
-0.0022457344,
-0.022029584,
0.005510738,
0.003458832,
0.032723557,
-0.007565986,
0.0030695044,
0.014463599,
-0.019195681,
-0.0040937867,
0.015492894,
0.021976115,
0.003056137,
-0.0021454783,
0.011930464,
0.014490333,
0.0058582923,
-0.020706205,
0.01493146,
-0.00075192,
0.033632547,
-0.01899517,
0.014156147,
0.013902165,
0.037161555,
0.01208419,
-0.017244032,
0.046197962,
-0.013888798,
-0.01620137,
-0.0015314104,
0.00540714,
0.006262658,
-0.034327652,
-0.010246163,
0.010279582,
-0.012511948,
0.00997213,
-0.01851394,
0.005988625,
0.007044655,
0.011803472,
-0.012003984,
-0.008615332,
0.006566768,
0.01994426,
-0.00696445,
0.016548924,
0.01477105,
-0.010460042,
0.007365474,
0.007158278,
0.0048223133,
-0.006262658,
0.016949948,
-0.012966442,
-0.011629696,
0.013541243,
-0.0086287,
0.0012498581,
0.020505693,
-0.015639935,
0.0019884107,
-0.009370594,
0.033418667,
0.022270199,
-0.019596705,
0.00014860863,
0.011068262,
-0.016816273,
0.017431175,
0.0094307475,
-0.0071315435,
0.005303542,
0.0118101565,
-0.0017862277,
0.013046647,
0.0100523345,
0.028312294,
-0.011215304,
-0.027029017,
-0.0065935026,
0.018701086,
0.033151317,
-0.013902165,
0.0092035,
0.022604385,
0.01477105,
-0.02780433,
-0.009584473,
0.034621738,
0.0018146336,
-0.0049493043,
0.021548355,
-0.006389649,
-0.013728388,
-0.12576112,
-0.024769915,
-0.025144204,
0.011957198,
0.0042174356,
0.0142898215,
-0.010486777,
0.026240336,
-0.016589025,
0.032456208,
0.0026450874,
-0.003432097,
-0.012505265,
-0.01408931,
0.0016868071,
-0.005280149,
-0.016014224,
-0.014811153,
-0.008073949,
0.024021337,
-0.0034421226,
-0.0034989342,
0.0035724554,
-0.0029491973,
-0.0025899466,
0.016736068,
-0.013146903,
0.0075994045,
0.022831632,
0.018955067,
0.01242506,
-0.003031073,
0.009297073,
-0.018928332,
0.009290389,
-0.0038364627,
0.0032900677,
-0.03972811,
0.028740052,
-0.019503133,
-0.008274462,
0.008548494,
0.032322533,
-0.009858507,
0.014450231,
0.0049793813,
-0.0096914135,
0.013080066,
-0.008936151,
0.000006292108,
-0.028552908,
-0.008561863,
-0.02358021,
-0.024916958,
0.0086287,
0.001040156,
-0.028499437,
-0.009684729,
-0.027229529,
-0.006259316,
-0.0073320554,
0.015145339,
0.0051431325,
0.023018777,
-0.00076904707,
-0.010546931,
-0.0031747732,
-0.036011953,
0.0048523904,
-0.0334454,
0.0040169237,
0.019690277,
-0.014530436,
0.00078492094,
-0.016214736,
-0.014182881,
-0.038872592,
-0.013407568,
0.014851255,
-0.0061523765,
-0.0027420016,
-0.013628132,
0.031467017,
0.00857523,
-0.0036927625,
0.026200235,
0.011155151,
-0.014329924,
0.024288686,
-0.035049498,
0.010125856,
0.021869175,
0.013140219,
0.0071181757,
-0.008301197,
0.004808946,
-0.00886263,
-0.030825377,
-0.00923692,
0.023941131,
-0.039754845,
-0.021174066,
-0.046973277,
0.025291245,
0.021321109,
-0.008635383,
0.0062526325,
-0.03197498,
0.008174205,
-0.017056886,
0.015586466,
0.0051063723,
-0.027884535,
0.018714452,
-0.0059752576,
-0.009063142,
-0.027336469,
0.0023944473,
0.0334454,
-0.0013275564,
0.030317415,
0.030397618,
-0.011208621,
-0.0069243475,
0.030370884,
0.04443346,
-0.018340163,
-0.004274247,
-0.009457482,
0.023700519,
-0.01337415,
-0.013902165,
0.0077263955,
-0.014998297,
-0.017310869,
0.0267483,
-0.001640021,
-0.027135957,
-0.014811153,
0.011088314,
0.007064706,
0.04574347,
-0.0134610385,
-0.035664402,
0.014530436,
-0.01634841,
-0.007084757,
-0.014209617,
-0.03381969,
0.0034003493,
-0.008889365,
-0.0047922367,
0.037856665,
-0.00058440893,
-0.005360354,
-0.036172364,
-0.0034989342,
-0.004187359,
-0.004631827,
-0.0104667265,
0.022778163,
-0.002379409,
0.030825377,
0.029301487,
-0.019877423,
-0.030477824,
-0.013701653,
-0.010680606,
-0.017177194,
0.0100256,
-0.0023142425,
-0.025063999,
-0.027777595,
0.028579643,
0.024221849,
0.03138681,
0.0074724136,
-0.005584259,
-0.023393067,
0.02289847,
0.0143432915,
0.0049660136,
0.0040670517,
-0.015920652,
-0.008688853,
0.022069687,
0.024074808,
-0.017030152,
-0.029141076,
0.011409133,
-0.01477105,
-0.0039266935,
0.0065801353,
0.015706774,
0.007813284,
0.013247159,
0.023032144,
0.014383393,
-0.003104594,
-0.019035272,
0.010226112,
0.013862062,
-0.0030110218,
0.004461392,
0.011803472,
-0.031894773,
-0.036386244,
0.0167227,
-0.033792954,
-0.011295509,
0.019529868,
0.015385954,
0.012652307,
-0.018353531,
0.00011988946,
-0.0074590463,
-0.010292949,
0.024462463,
0.007846703,
-0.011101681,
0.0017678475,
0.027991474,
0.0068708775,
0.02236377,
-0.0016533885,
-0.017364338,
0.012565418,
-0.0037395486,
0.0020585898,
-0.045877144,
0.013293945,
0.0011120061,
0.00420741,
-0.0077798655,
-0.01883476,
0.0024178405,
0.0015832093,
-0.0078066005,
-0.007666242,
0.002803826,
0.0039400607,
0.07159615,
0.010212745,
0.0025515151,
-0.008962886,
-0.01152944,
0.036653593,
0.0062994184,
0.012658991,
0.005082979,
-0.029943125,
0.023446536,
-0.0025331348,
0.004732083,
-0.00076194556,
-0.015172075,
0.0011253735,
-0.024342157,
0.0052701235,
-0.02268459,
-0.012719144,
0.021575091,
-0.01761832,
0.009250287,
0.032028448,
-0.02658789,
0.011629696,
0.045128565,
0.017698525,
0.018500574,
0.002379409,
0.0079870615,
-0.001539765,
-0.023152452,
-0.010179326,
0.0058816853,
-0.0020435513,
0.00053929375,
-0.00841482,
0.012939707,
0.02126764,
-0.022885103,
0.00071265304,
0.009450799,
-0.011536123,
-0.028445968,
-0.0017979242,
-0.006115616,
-0.02358021,
-0.011763371
] |
A 3' overhang is critical for the protection and maintenance of mammalian telomeres, but its synthesis must be regulated to avoid excessive resection of the 5' end, which could cause telomere shortening. How this balance is achieved in mammals has not been resolved. Here, we determine the mechanism for 3' overhang synthesis in mouse cells by evaluating changes in telomeric overhangs throughout the cell cycle and at leading- and lagging-end telomeres. Apollo, a nuclease bound to the shelterin subunit TRF2, initiates formation of the 3' overhang | [
-0.012551334,
-0.022015736,
-0.0028012265,
-0.041693285,
-0.02082037,
0.027559077,
-0.016840199,
0.027821794,
-0.014331246,
0.006489125,
0.024734862,
0.004613978,
0.003838961,
0.0075202915,
-0.009411858,
0.0049095354,
0.026140403,
-0.0017437881,
-0.00010949988,
-0.0017881218,
-0.03402193,
-0.013247536,
-0.026009044,
0.003957184,
0.023066606,
0.00045441938,
0.022895839,
-0.036517747,
-0.0015475709,
-0.0082821725,
0.010732015,
0.015421524,
-0.012846891,
-0.0065055448,
-0.007349525,
0.006160728,
0.02589082,
-0.006643472,
0.022357268,
-0.03551942,
0.02656075,
0.012170393,
-0.0027831646,
0.0045942743,
-0.014055392,
-0.0143181095,
0.015132534,
-0.012997954,
-0.03326005,
0.018666087,
-0.010009541,
0.018298281,
-0.026337441,
0.008945535,
-0.021858105,
0.0016748247,
-0.019296609,
0.028005697,
-0.015500339,
-0.0029079556,
-0.0009966849,
0.005825763,
-0.016511802,
0.013700724,
0.021017408,
0.019244066,
0.001962172,
-0.0058684545,
-0.0011502105,
-0.009306772,
0.009871614,
0.011907675,
-0.005697688,
0.002512237,
0.0031673892,
-0.02984472,
-0.01677452,
0.0025467188,
-0.002756893,
0.019585598,
0.013149017,
-0.0016042194,
-0.0039210604,
0.01077799,
0.006702583,
-0.0062264074,
0.003960468,
0.006689447,
0.029109111,
0.004183778,
0.031604927,
0.019743228,
0.017024102,
0.018626679,
-0.013319783,
-0.001975308,
-0.016196541,
0.026508207,
-0.009063758,
-0.028005697,
-0.027086185,
-0.005270772,
0.013674452,
-0.002962141,
-0.008551458,
-0.0025664226,
0.007579403,
-0.0009802651,
0.011855132,
-0.012682693,
-0.00459099,
0.031132037,
-0.010213147,
-0.028005697,
0.007027696,
-0.019822044,
0.013976577,
0.002213396,
-0.011566143,
0.011277153,
0.031841375,
0.033522766,
0.005940702,
-0.019270336,
-0.008682817,
0.0032642663,
0.004725633,
-0.012735236,
-0.019493647,
0.007480884,
0.042428896,
0.015776193,
0.0065843603,
0.021976328,
-0.025943365,
0.0067584105,
-0.022199638,
-0.019152114,
-0.0010861731,
-0.049601085,
0.020137304,
0.02053138,
0.00076598604,
0.0038061214,
0.018823717,
0.015224486,
-0.003957184,
0.019401696,
0.007139351,
0.0111129545,
-0.00045893484,
-0.014462604,
0.012958546,
0.0007627021,
0.018219465,
0.014147343,
-0.01686647,
0.022764482,
-0.034337193,
-0.01807497,
0.029345557,
-0.0077436017,
0.030527785,
-0.002756893,
0.015145671,
0.019401696,
-0.014751594,
0.005060598,
-0.005090154,
0.0008386439,
0.009615464,
0.01751013,
0.00419363,
0.01498804,
-0.05354185,
0.007139351,
-0.00072124193,
0.009333043,
-0.004722349,
-0.023578906,
-0.016367307,
0.010456161,
0.0012979892,
0.024603505,
-0.049601085,
0.018521592,
-0.000061420506,
-0.014896088,
0.004633682,
-0.0116449585,
-0.0048766956,
-0.0129519785,
0.0045417305,
-0.014002848,
-0.64019024,
-0.033522766,
-0.010160604,
-0.015789328,
-0.007375797,
0.013753267,
0.011336265,
-0.0025762746,
-0.00985191,
0.027795523,
-0.017812254,
0.02298779,
0.02669211,
-0.028215872,
-0.025483608,
-0.03638639,
-0.004318421,
-0.0069554485,
0.007231302,
-0.0158156,
-0.054802895,
-0.0013932243,
-0.01613086,
0.00414437,
0.012906003,
0.004292149,
0.035677053,
-0.027375175,
-0.023618313,
0.045318786,
-0.0062888027,
0.0003364017,
-0.023145422,
-0.0130110895,
0.037621163,
-0.0017257263,
-0.0057797874,
0.009326475,
0.009379019,
0.019138979,
-0.009352747,
-0.010436457,
0.008774769,
0.011244314,
-0.013989713,
-0.00096466625,
0.023197966,
-0.009319907,
0.02043943,
0.01900762,
0.0038356772,
0.007585971,
-0.009319907,
0.0072378702,
0.0028783998,
0.0202818,
0.036806736,
-0.007244438,
0.024209429,
0.011677798,
-0.009937294,
0.03173629,
-0.020991137,
-0.02365772,
-0.037122,
0.024288243,
-0.013608772,
0.020334342,
0.015684241,
0.011014435,
0.018377097,
0.035860952,
-0.006482557,
-0.0081442455,
-0.0075268596,
0.024918765,
-0.0022363837,
-0.0035893794,
0.017260548,
0.025812006,
0.031079493,
0.0011510316,
-0.027690437,
0.010337938,
0.03315496,
-0.017680895,
-0.02608786,
0.022948382,
-0.0100817885,
-0.015158806,
0.00660078,
0.009878182,
-0.024419602,
-0.026337441,
-0.013963441,
0.014331246,
0.0009351105,
0.0067912503,
0.011809156,
-0.022567444,
-0.016564345,
-0.015933823,
-0.008623705,
-0.004085259,
0.028715035,
-0.0043217046,
-0.007828984,
-0.0030590182,
0.05112485,
-0.021266991,
0.0072772778,
0.0051821047,
-0.014567692,
-0.009050622,
0.005362723,
-0.010876509,
0.032025278,
0.0098059345,
-0.013845218,
-0.026219217,
0.0073429574,
0.011684366,
-0.00043389454,
-0.00073971425,
0.028215872,
0.016827064,
0.013740131,
-0.010364209,
0.005457958,
0.017260548,
-0.0020623333,
0.020780964,
0.026140403,
-0.035099074,
0.03798897,
0.01751013,
0.02401239,
-0.005513786,
0.016498666,
-0.040484782,
-0.023775944,
0.010600655,
-0.019270336,
0.006144308,
-0.014633371,
-0.03252444,
-0.010876509,
-0.009674576,
0.03412702,
-0.011874836,
-0.009011214,
-0.012137554,
0.009832206,
0.0017208003,
0.005297044,
0.004042567,
-0.016446123,
-0.030606601,
-0.026547614,
-0.00044415696,
-0.0025746326,
-0.004446496,
0.00038442976,
0.02611413,
-0.013076769,
-0.008695953,
0.024248835,
-0.024931902,
-0.0070868074,
-0.024918765,
-0.0021378645,
-0.014186751,
-0.031105764,
-0.022869568,
0.005132845,
0.029503187,
-0.0074020685,
0.012866595,
-0.007467748,
-0.0099241575,
0.00374701,
0.012058739,
-0.00017045857,
0.010580951,
0.009365883,
0.0008172981,
0.057219896,
0.011631822,
0.036649108,
0.045161158,
0.00198516,
0.0143575175,
-0.009510377,
-0.00040351783,
-0.0058651706,
-0.033811755,
0.0128731625,
0.0067912503,
0.019966539,
0.04487217,
0.030974407,
-0.011513599,
0.0047748927,
-0.030948134,
0.012288616,
0.009122869,
0.008971807,
-0.0044399276,
0.0063282102,
0.001535256,
-0.02557556,
-0.016564345,
-0.019060163,
-0.008137678,
0.0043578283,
0.01833769,
-0.0005746948,
-0.0012667915,
-0.012104714,
-0.00004056216,
-0.00012160952,
-0.0010163888,
0.0147121865,
-0.025457336,
0.011933948,
0.0130504975,
-0.0004490829,
0.00462383,
-0.015158806,
-0.016301628,
-0.024445873,
-0.0098847505,
-0.031237124,
0.01639358,
0.032944787,
0.030632874,
0.0039112084,
-0.003078722,
0.03178883,
0.00902435,
0.0049325232,
0.015933823,
0.013753267,
-0.01916525,
0.015828736,
-0.0014145701,
0.038225412,
0.024945037,
0.005274056,
-0.010048948,
-0.0067781145,
0.026127266,
-0.017194867,
0.01610459,
0.013240968,
-0.0021427905,
0.016301628,
0.019585598,
0.027979426,
0.014685915,
-0.003402193,
0.005599169,
-0.002620608,
-0.010699174,
-0.0062165554,
0.006902905,
0.029266741,
0.000441694,
-0.0016304912,
-0.016905878,
-0.014672779,
0.0033956252,
0.015487203,
-0.0338643,
0.017799119,
-0.0001650195,
0.026363712,
0.035939768,
0.012623581,
0.014502012,
-0.035414334,
-0.03938137,
0.03446855,
0.020833507,
-0.029503187,
0.013352622,
-0.019020755,
0.007264142,
0.0056155887,
0.023854759,
-0.00040084962,
0.006347914,
-0.0053265993,
0.003832393,
-0.021477165,
-0.034704998,
0.009543217,
-0.010981596,
0.018022427,
-0.01230832,
0.016748248,
0.022475492,
-0.013103041,
-0.0038520969,
0.0192572,
-0.00084151735,
0.008512051,
-0.012459382,
-0.000044025724,
-0.031604927,
-0.019336017,
-0.02238354,
0.009713984,
-0.020321207,
-0.0026797196,
0.00021633154,
0.0028521281,
-0.013818947,
0.01655121,
-0.0037831336,
-0.012012763,
0.009878182,
-0.011178634,
0.0018143934,
0.022619987,
0.019336017,
0.0010894571,
0.023592042,
0.00909003,
0.024038661,
0.021726746,
-0.03549315,
0.019966539,
-0.025706919,
-0.024603505,
0.005950554,
0.01833769,
0.0032297845,
0.013378894,
0.01058752,
0.00004895168,
-0.027716707,
-0.00025040272,
-0.00005654586,
0.019966539,
-0.009976701,
0.031263396,
0.044451818,
0.010915916,
0.008814176,
-0.0036944663,
0.016813926,
0.008347852,
0.006042505,
0.019874588,
-0.005392279,
-0.004407088,
0.017694032,
0.0072115986,
-0.030028623,
0.011585847,
0.0014827126,
0.022803888,
0.018771173,
-0.012741804,
0.008604002,
0.009871614,
-0.00022844117,
-0.016735112,
-0.014410061,
0.0064267297,
0.016840199,
0.0012733594,
-0.006252679,
0.02541793,
-0.030159982,
-0.03502026,
-0.0074217725,
0.0005919356,
-0.0075334273,
-0.0085186185,
-0.010594088,
-0.008229629,
-0.021753019,
-0.00328397,
-0.023867896,
0.0023332608,
-0.004502323,
0.033943117,
-0.015014311,
0.0127943475,
0.008052295,
-0.017575808,
-0.027033642,
0.0060293693,
-0.015053719,
-0.055958852,
0.0019457523,
0.016735112,
0.017615216,
0.023828488,
-0.003924344,
-0.015001176,
0.042849243,
-0.007914368,
-0.0033496495,
-0.010666335,
-0.026731517,
-0.013109609,
-0.002747041,
0.012032467,
-0.022751344,
0.01820633,
0.0010689322,
0.0065318164,
-0.0057633677,
0.011053843,
-0.0007466927,
-0.007809281,
0.009385587,
0.018508455,
0.04815614,
0.009221388,
0.0035565395,
-0.02381535,
-0.03102695,
-0.030974407,
-0.025299706,
-0.025260298,
0.00073396735,
-0.006272383,
0.0010508704,
-0.004167358,
-0.008551458,
0.016275356,
-0.0051197093,
0.004505607,
0.0099044535,
0.019020755,
0.021792427,
0.01253163,
0.036964368,
-0.016025774,
-0.017996157,
-0.0040097274,
-0.032025278,
0.025614968,
-0.01402912,
-0.016065182,
0.022541171,
0.007349525,
-0.015447795,
-0.011106387,
-0.009004646,
0.011145795,
0.027059915,
-0.003740442,
-0.019375423,
-0.0021050249,
-0.018022427,
-0.038593218,
-0.018889396,
-0.0043446925,
0.009339611,
-0.02541793,
0.0035401199,
0.007132783,
-0.007999751,
0.0064464333,
-0.028583676,
0.016695704,
0.023171693,
0.02117504,
0.0007052326,
-0.024511553,
0.00042199017,
-0.029634546,
-0.0021083087,
-0.024931902,
-0.01552661,
0.009070326,
-0.019848315,
0.03281343,
0.026508207,
0.04652729,
-0.027138729,
0.005796207,
0.013326351,
0.0068897693,
-0.0059078624,
-0.016643161,
0.023697129,
-0.015290165,
0.033627853,
0.016905878,
-0.006810954,
0.021083089,
0.0003774513,
0.019795772,
0.030238798,
-0.0045745703,
-0.025247162,
0.010193443,
-0.02937183,
-0.032130364,
0.008886423,
-0.021096224,
-0.020912321,
-0.008715657,
-0.010975028,
0.009333043,
0.012098146,
0.021529708,
-0.014528284,
0.0033381556,
-0.005195241,
0.02177929,
-0.013017657,
0.004955511,
-0.021805562,
-0.02729636,
-0.006935745,
-0.0024941752,
0.009313339,
-0.0044760513,
0.007487452,
-0.000010852495,
-0.026744653,
-0.008045726,
0.02171361,
-0.021188175,
-0.018836852,
0.0035499716,
-0.026455663,
-0.018928804,
-0.019913996,
0.0067452746,
-0.040537328,
-0.00749402,
0.013726995,
-0.00419363,
0.013661316,
-0.019716958,
-0.0046599535,
0.027795523,
0.005175537,
0.020715283,
-0.0016830347,
0.007947207,
0.0046927934,
0.0041410862,
-0.018508455,
-0.0015139102,
0.010666335,
0.004407088,
0.022436084,
0.0076385145,
-0.016446123,
0.011441352,
-0.015763057,
0.018797444,
-0.023999253,
-0.039039835,
0.0026616578,
0.010863373,
-0.0029046715,
-0.009989837,
0.00033106524,
-0.011592414,
0.022436084,
0.005842183,
0.0024317799,
0.011283722,
-0.023605177,
-0.004167358,
0.029608274,
0.01903389,
0.007040832,
-0.009208253,
-0.014002848,
-0.030238798,
-0.03402193,
-0.018219465,
-0.0034448847,
-0.021280127,
0.028557405,
-0.027112458,
-0.012984818,
0.010232851,
-0.016052047,
-0.009595761,
-0.01483041,
-0.00040782805,
0.04266534,
0.00507045,
0.0049522268,
0.010423321,
0.0055433414,
-0.021188175,
0.01093562,
-0.0022856432,
-0.030238798,
-0.02952946,
0.006285519,
0.010094924,
0.001217532,
-0.009201684,
-0.030685417,
-0.0066369036,
-0.0054546744,
-0.029319284,
-0.0028981036,
0.003756862,
-0.022685666,
-0.023802215,
0.008242765,
0.010909349,
0.02392044,
-0.0038159732,
-0.025115803,
-0.037043184,
0.026337441,
-0.012433111,
0.0033693532,
-0.0022593713,
0.0011387166,
-0.019716958,
-0.015907552,
-0.01211785,
-0.016853334,
-0.0014145701,
-0.029161654,
-0.031342212,
-0.010764854,
0.016853334,
0.03220918,
-0.0062920866,
-0.020268664,
0.013818947,
-0.016735112,
0.031079493,
-0.007934072,
-0.012958546,
0.044478092,
-0.006689447,
-0.0021115928,
0.013254103,
-0.010469297,
-0.008223061,
-0.003513848,
-0.033338863,
-0.0022642973,
0.00003727819,
0.0025138792,
0.004804448,
-0.007369229,
-0.014488876,
-0.016827064,
-0.016498666,
-0.017418178,
-0.009530081,
0.00082304503,
-0.017181732,
-0.0042461734,
-0.027926883,
0.011047276,
0.02021612,
-0.0032626244,
-0.011822293,
0.002320125,
-0.0020262096,
-0.035099074,
-0.025562424,
-0.025943365,
-0.014646507,
0.04011698,
-0.000039689858,
-0.009484106,
-0.009424995,
0.001763492,
-0.038146596,
-0.02296152,
0.019559326,
0.011060411,
0.0048766956,
0.012630149,
0.003183809,
0.0036550588,
-0.0043381248,
0.021437757,
0.0071065114,
-0.026954826,
0.013858354,
-0.025089532,
0.027506534,
0.020623332,
-0.032944787,
0.011802589,
0.036622833,
0.0000993401,
-0.033207506,
0.025903957,
-0.012860027,
0.012492223,
-0.01884999,
0.00937245,
0.020597061,
0.016117726,
0.017877933,
-0.038409315,
0.006830658,
0.02515521,
-0.011907675,
-0.019585598,
-0.0054316865,
-0.011237746,
-0.0033562174,
0.008374124,
-0.002990055,
-0.03967036,
0.008794472,
-0.010186875,
0.023578906,
0.018298281,
0.0019326165,
0.005641861,
0.0010878152,
-0.013766402,
-0.003195303,
-0.0037174542,
-0.024367059,
0.013260671,
0.013884625,
0.010193443,
-0.0099241575,
-0.011244314,
0.0059899613,
-0.024025526,
0.0032823281,
-0.0014088232,
-0.024183156,
-0.032393083,
0.018153787,
0.0033956252,
0.0035565395,
0.004167358,
0.018166922,
-0.028609948,
0.01339203,
0.019375423,
-0.0021838401,
-0.0013932243,
0.013608772,
-0.0027963005,
-0.013635044,
0.0022725074,
0.0015081633,
-0.01552661,
-0.031893916,
0.01655121,
0.19535682,
-0.02311915,
-0.0014827126,
0.015697377,
-0.0064497176,
-0.0064004576,
0.025181483,
0.024669183,
-0.025706919,
-0.0014950274,
0.011500464,
0.0037667137,
-0.016354172,
-0.0011658093,
0.023749672,
-0.015342709,
-0.027059915,
0.01693215,
-0.023933575,
0.031657472,
0.0041804938,
-0.0071918946,
0.010298531,
0.0066598915,
0.03115831,
0.011796021,
-0.029187927,
-0.0016625099,
-0.021056816,
0.024051797,
-0.037095726,
-0.026876012,
0.003306958,
0.021214448,
-0.0072904136,
0.0064234454,
-0.008315013,
0.0036911825,
-0.009267364,
-0.011034139,
0.012433111,
0.0001398766,
0.007251006,
0.0010360925,
0.012328024,
0.010791126,
0.01055468,
-0.019178385,
-0.018771173,
0.006948881,
-0.04655356,
0.01469905,
0.027427718,
0.025523016,
0.018731765,
0.011835428,
0.0098453425,
0.0027995845,
0.01498804,
0.03819914,
-0.025995908,
0.010672903,
-0.046895094,
-0.0061705797,
-0.035440605,
0.029214198,
-0.0008571162,
0.0016731828,
0.030081166,
-0.032682072,
0.0015705588,
-0.0077567375,
-0.0027240533,
0.016800791,
-0.016406715,
-0.0031542534,
0.02283016,
0.009989837,
0.012958546,
0.015487203,
-0.0057370956,
-0.006689447,
-0.011336265,
-0.01007522,
-0.0017749858,
-0.032918517,
0.013884625,
0.0055466257,
0.012025898,
0.013103041,
-0.003622219,
0.0073166853,
-0.010929053,
0.008085134,
0.0023398288,
0.0059932456,
0.004035999,
0.01326724,
-0.013503686,
-0.014002848,
-0.03502026,
0.040616143,
-0.000040664785,
0.005034326,
0.0013932243,
-0.012997954,
-0.0116252545,
0.028504862,
-0.023526361,
-0.027795523,
-0.001533614,
-0.016905878,
0.010364209,
-0.0042034816,
-0.006689447,
0.0064004576,
0.02063647,
-0.03473127,
0.022199638,
-0.02283016,
-0.01196022,
-0.007513724,
0.0013858353,
0.03549315,
-0.01253163,
-0.012991386,
-0.030554058,
0.0069882884,
-0.017641488,
-0.02381535,
0.0082624685,
0.023605177,
-0.00039838662,
0.004098395,
0.009668008,
-0.022055143,
0.007993183,
-0.0045417305,
-0.012840323,
0.009582625,
-0.0018160355,
-0.0187449,
-0.012104714,
-0.006935745,
0.000016060667,
-0.016235948,
0.015868144,
-0.0027913747,
-0.019598734,
-0.016656296,
-0.016984694,
-0.0008989868,
-0.016183404,
-0.0023250508,
-0.008695953,
-0.01715546,
-0.0075202915,
-0.04237635,
-0.010620359,
0.019138979,
-0.018009292,
0.0034613046,
-0.0023726684,
-0.019375423,
-0.0025089532,
0.01699783,
-0.16435614,
0.008019455,
0.0052477843,
-0.028504862,
0.017654624,
0.023106014,
0.029109111,
-0.0011305067,
-0.009155708,
-0.00065474154,
0.03533552,
0.026547614,
-0.0407475,
-0.03194646,
-0.020071626,
0.0015204782,
0.007382365,
0.010863373,
0.027637893,
-0.006968585,
0.006722287,
-0.02834723,
0.02560183,
-0.00682409,
-0.004305285,
-0.0074546123,
-0.007901232,
-0.021805562,
0.012866595,
0.014042256,
-0.026770925,
0.017299954,
0.009523514,
-0.008899559,
0.026219217,
0.0049949186,
0.0037108862,
0.007283846,
-0.012643285,
0.01884999,
0.023211101,
0.010154036,
0.023723401,
0.0044399276,
0.0049029673,
0.028163329,
0.010410185,
-0.0048898314,
0.018561,
-0.017299954,
0.009832206,
-0.020111034,
-0.0030146847,
0.0035992314,
-0.008866719,
-0.0016132504,
0.020255528,
0.017273683,
0.005090154,
-0.00039879713,
-0.013700724,
-0.011086683,
0.027165001,
-0.014869817,
-0.0114085125,
-0.012899435,
-0.011999627,
0.018889396,
-0.03310242,
0.01077799,
-0.017694032,
-0.019664412,
0.005090154,
-0.02678406,
0.028504862,
0.03205155,
-0.0008727151,
0.00067731884,
-0.010035813,
0.0013702365,
0.0016001144,
0.01699783,
-0.032576982,
-0.023959845,
-0.0046829414,
-0.0022330997,
-0.022199638,
0.031867646,
-0.003305316,
0.0037699977,
0.016590618,
-0.017326226,
-0.003526984,
-0.023894167,
0.034967713,
0.02104368,
-0.00058742013,
-0.015776193,
0.0002528657,
-0.0027765967,
0.021319535,
-0.027821794,
-0.016078318,
0.024656048,
0.011585847,
0.026862876,
-0.011789453,
-0.011053843,
0.043374676,
0.0067452746,
-0.0116252545,
0.008564594,
0.0063314945,
0.00054472854,
-0.00546781,
0.03249817,
0.0012733594,
-0.005592601,
0.00020668487,
-0.011178634,
0.06042505,
0.02745399,
-0.025930228,
0.015487203,
-0.010929053,
-0.01588128,
-0.12515867,
-0.025089532,
-0.0006588465,
0.02640312,
-0.003408761,
0.020912321,
-0.0040064435,
0.03701691,
-0.002860338,
0.037857607,
-0.028137056,
-0.027480261,
-0.0046730894,
0.004078691,
-0.014068528,
0.003622219,
-0.011290289,
-0.026035314,
-0.00008558847,
0.019230928,
-0.0011485686,
-0.002418644,
-0.008906127,
-0.011579279,
0.01119177,
-0.018955076,
-0.024800543,
0.0038520969,
0.011421648,
0.0064628534,
-0.008071998,
-0.0084200995,
0.0020656171,
0.021122497,
-0.027191272,
-0.040931404,
0.0016830347,
-0.009956998,
0.03089559,
-0.016157134,
-0.022790752,
-0.0008448013,
0.011677798,
-0.0019982958,
0.009234524,
-0.015093126,
-0.008026023,
0.0036452068,
-0.0077436017,
0.0003526163,
-0.024143748,
-0.023972983,
-0.035282977,
-0.013306647,
0.036780465,
-0.012925707,
0.017326226,
0.011631822,
-0.013726995,
0.0015007744,
0.0064004576,
0.01932288,
-0.009379019,
0.0009695922,
0.04206109,
-0.0022248898,
-0.005142697,
-0.035887226,
0.028977752,
0.0040097274,
0.0083806915,
0.011119523,
-0.009175412,
0.008847016,
-0.006810954,
-0.007329821,
-0.021345805,
-0.03412702,
-0.018994484,
0.0022840013,
0.006715719,
-0.022304725,
0.01865295,
-0.019336017,
0.0005796207,
-0.00070769555,
0.00483072,
0.016827064,
0.016721975,
-0.016853334,
0.005858603,
0.030764231,
-0.016603753,
-0.012426543,
-0.025325978,
0.02334246,
-0.008722224,
0.009122869,
0.019690685,
0.013740131,
-0.025706919,
-0.011618686,
-0.053200316,
0.01610459,
0.0100620845,
-0.009858479,
0.010732015,
-0.009648304,
0.010016109,
-0.01339203,
-0.0074414765,
0.0022101118,
-0.024156883,
-0.002980203,
-0.024288243,
-0.007966911,
-0.030081166,
0.010016109,
0.0027306213,
-0.014068528,
0.025457336,
0.030370155,
0.009260796,
-0.0021411486,
-0.007139351,
0.001549213,
-0.0081836535,
0.0033184518,
-0.001651837,
0.0033496495,
-0.0074546123,
-0.0063150744,
0.011927379,
-0.03149984,
-0.012282048,
-0.0018538012,
-0.011493895,
-0.009582625,
-0.0013981502,
0.016196541,
0.03205155,
0.006285519,
-0.011914244,
-0.046343386,
0.015303301,
0.008814176,
-0.0028094365,
-0.0053331675,
-0.02334246,
0.0032757602,
-0.004512175,
-0.008505482,
0.034363464,
0.014147343,
0.0013891193,
-0.017299954,
-0.0034810083,
0.0005636114,
-0.007953776,
-0.0014449469,
-0.003513848,
-0.038698304,
0.016748248,
0.029056568,
0.0022413095,
0.0015237621,
0.012768076,
0.0062099877,
-0.02506326,
-0.013674452,
-0.010278827,
-0.020518245,
-0.030659145,
0.024261972,
-0.0021510005,
0.0022840013,
0.0018899249,
-0.0007532606,
-0.021004273,
0.012137554,
-0.019020755,
-0.0016124294,
0.022304725,
-0.016367307,
-0.00943813,
0.013608772,
0.03149984,
-0.01648553,
0.019861452,
0.021096224,
-0.001429348,
-0.0083412845,
-0.006916041,
0.024511553,
-0.010180308,
0.01106698,
0.009188549,
0.020189848,
-0.010482432,
-0.0053298837,
-0.004318421,
0.00021468954,
-0.010607224,
-0.01807497,
0.014620235,
-0.004613978,
-0.010449593,
0.036202487,
-0.012800915,
-0.042507708,
0.0067649786,
0.02340814,
0.027165001,
0.007513724,
0.03420583,
0.006177148,
0.001995012,
0.029424373,
-0.019493647,
-0.0016124294,
-0.01393717,
0.020242391,
0.008006319,
0.011178634,
-0.0069751525,
-0.0030918578,
0.033286322,
0.020386886,
0.031841375,
-0.030317612,
0.0044727675,
-0.0017010965,
0.027191272,
-0.010561248,
-0.033365138,
-0.005618873,
-0.0115070315,
-0.007920936,
0.0023726684,
0.017483857,
0.0097271195,
0.08081194,
0.013293511,
-0.015303301,
-0.003980172,
-0.016735112,
0.038172867,
0.007888096,
0.013017657,
-0.019493647,
-0.023933575,
0.030422699,
0.011283722,
0.019808907,
-0.018114379,
-0.008308444,
0.003990024,
-0.0025647806,
0.0032396365,
-0.011901108,
-0.0018587271,
0.016564345,
-0.017076645,
-0.0070802397,
-0.004308569,
-0.03549315,
0.025693782,
0.04292806,
-0.004531879,
0.028741306,
-0.020899186,
-0.007691058,
-0.0052674883,
-0.016406715,
0.0098059345,
0.0044957553,
0.0065646563,
-0.0010672903,
-0.009103165,
0.040327154,
0.00459099,
0.002103383,
-0.006666459,
-0.005966974,
-0.025194619,
-0.0187449,
0.015053719,
0.017785983,
0.01641985,
-0.014107936
] |
G-quadruplex (G4)-forming genomic sequences, including telomeres, represent natural replication fork barriers. Stalled replication forks can be stabilized and restarted by homologous recombination (HR), which also repairs DNA double-strand breaks (DSBs) arising at collapsed forks. We have previously shown that HR facilitates telomere replication. Here, we demonstrate that the replication efficiency of guanine-rich (G-rich) telomeric repeats is decreased significantly in cells lacking HR. Treatment with the G4-stabilizing compound pyridostatin (PDS) increases telomere fragility in BRCA2-deficient | [
-0.042524755,
-0.003681618,
-0.01233411,
-0.031548847,
-0.013402744,
0.015622746,
0.003042161,
0.0114998855,
-0.017415294,
-0.013581999,
0.012671936,
0.026529713,
0.015608957,
-0.0018201257,
-0.0063394154,
0.0051949425,
0.022834305,
-0.0269158,
0.005339725,
-0.01227206,
-0.038774196,
0.0073770247,
-0.012885663,
-0.022972193,
0.012223799,
0.0040573636,
0.0145334285,
-0.033093195,
-0.009300567,
0.015843367,
0.001279776,
0.0029232323,
-0.014919516,
-0.005970564,
-0.0004220675,
-0.0075907516,
0.016422499,
-0.0069702542,
0.00025530884,
-0.024888841,
0.001375436,
0.018049581,
-0.0060291667,
0.010982804,
-0.01114827,
0.012437526,
0.02042126,
-0.014561006,
-0.009410878,
0.014740261,
0.013430322,
0.013637154,
-0.0396291,
0.017842747,
-0.009307461,
-0.0017348074,
0.017787592,
0.017677283,
-0.0053431722,
-0.009079945,
-0.01191355,
-0.012403054,
-0.019966228,
0.019097531,
-0.018932065,
0.017787592,
0.0010522602,
-0.010334729,
0.013485477,
-0.011196531,
0.027163997,
0.01759455,
-0.016298398,
0.004615811,
0.018477034,
-0.03882935,
-0.011113798,
-0.004474476,
0.008335349,
0.026171202,
0.02832226,
-0.019456042,
-0.004812302,
0.010355413,
0.008673175,
0.009631499,
-0.023372069,
0.010314046,
0.018477034,
-0.0010324387,
0.008928268,
0.038443264,
0.019180264,
0.031052448,
-0.01840809,
0.0028663534,
0.010493301,
0.02513704,
-0.013802621,
-0.028846236,
-0.031328224,
-0.009721126,
0.011789451,
-0.011134481,
-0.009141996,
0.0071977703,
0.023234181,
-0.018987222,
-0.013306223,
-0.006646217,
-0.03800202,
0.009714232,
-0.003960842,
-0.023785735,
0.01781517,
-0.019028587,
0.020200638,
-0.01214796,
-0.010265785,
0.011079326,
0.019538775,
0.0023561665,
0.031245492,
-0.018146103,
0.007411497,
-0.006801341,
0.0020045515,
0.005932645,
-0.017180884,
0.0013857776,
0.028735925,
0.034279034,
0.01664312,
0.0077975844,
-0.042304136,
-0.0009815925,
-0.0034110122,
-0.028763503,
-0.026226358,
-0.039132703,
0.01829778,
0.028791081,
-0.0058740424,
-0.013575105,
0.017415294,
0.0077010626,
0.014698895,
0.0013082154,
0.014230074,
0.017525606,
-0.005570688,
0.00017171404,
0.006263577,
0.0028439465,
-0.0012789142,
0.004860563,
-0.018215047,
0.021510577,
-0.04269022,
-0.016367342,
0.0110586425,
-0.015209082,
0.024695797,
-0.0018873463,
-0.006611745,
0.032376178,
-0.0068116826,
0.038636304,
0.011472308,
-0.021303745,
0.00522252,
0.024847474,
-0.03587854,
0.009459139,
-0.039353326,
0.008700753,
-0.012444421,
0.004250407,
-0.01865629,
-0.011458519,
-0.009438455,
-0.005870595,
0.009079945,
0.02373058,
-0.022930827,
0.007694168,
0.011948023,
-0.010624295,
-0.012375477,
-0.015650325,
0.0022992876,
0.0015072917,
0.012954608,
-0.004564103,
-0.62832946,
-0.012727091,
0.0005545696,
-0.01958014,
0.012341004,
0.03645767,
0.01055535,
0.019194053,
-0.023771945,
0.012327216,
0.004957085,
0.005401775,
0.009672865,
-0.011051749,
-0.019138899,
-0.05653421,
0.005867148,
-0.0009919341,
0.011437836,
0.015264236,
-0.013037341,
0.0011427494,
-0.01782896,
-0.007742429,
0.017208463,
0.002111415,
0.024682008,
-0.01227206,
-0.015636535,
0.024626853,
-0.025040518,
0.0083973985,
-0.021138279,
0.00030141525,
0.05154265,
-0.00193216,
-0.005743048,
0.02537145,
0.019649085,
0.04235929,
-0.00056232576,
0.013340695,
0.026184991,
-0.0029318503,
-0.025412817,
0.017663494,
0.00059507426,
0.004412426,
-0.008749014,
0.009741809,
-0.003242099,
0.0040573636,
-0.01150678,
0.023385858,
0.025881637,
0.027536297,
0.005553452,
-0.010817339,
0.015857156,
-0.00085318397,
0.012085911,
0.02785344,
0.004029786,
-0.030142386,
-0.02007654,
0.0011867014,
-0.023758156,
0.011086221,
0.022158653,
-0.007763112,
0.01416113,
0.0349409,
0.015746845,
0.0019855918,
-0.00011160335,
0.033699904,
-0.0003315783,
0.0144644845,
0.0011961812,
0.026295302,
0.012527154,
-0.0125340475,
-0.003698854,
0.021179644,
0.018780388,
-0.018104736,
-0.02476474,
0.027122632,
-0.0009126483,
-0.02101418,
0.0025043965,
0.008983424,
-0.0045399726,
-0.012051439,
-0.00045115335,
0.012051439,
-0.001392672,
0.0035040868,
-0.0053535136,
-0.02772934,
-0.030363007,
-0.0133131165,
-0.009624604,
0.0016020898,
0.010672555,
0.0114998855,
-0.038084753,
0.00055155327,
0.024461387,
-0.011003488,
-0.01021063,
0.010376096,
-0.005536216,
0.0010626018,
0.001532284,
-0.026819278,
0.0406219,
0.01214796,
-0.017760014,
-0.018228834,
0.018683868,
-0.016022623,
0.009459139,
-0.024861263,
0.009335039,
0.015305603,
0.010520878,
-0.0058637005,
0.00454342,
-0.0077010626,
-0.009059262,
0.007128826,
0.023661636,
-0.013002868,
0.020117905,
0.01274088,
0.021676043,
-0.008080255,
0.030500896,
-0.04994315,
-0.019207843,
-0.007280503,
-0.008438765,
-0.0039505004,
-0.00085232215,
-0.017856536,
-0.038663883,
-0.019745607,
0.010796655,
-0.021096913,
0.014354174,
0.00036583495,
-0.0059119617,
0.017084362,
-0.0036195682,
-0.0034575495,
0.0033972233,
-0.04155954,
-0.017167095,
-0.024240766,
0.015209082,
-0.009452244,
-0.009162678,
-0.0073425528,
-0.015319392,
-0.023441013,
0.016974052,
-0.004508948,
-0.0020062749,
-0.021538155,
-0.0027474246,
-0.029949343,
-0.03574065,
-0.00007384566,
-0.007066776,
0.037808977,
0.008514604,
0.024226977,
0.00477783,
-0.005556899,
-0.0032765712,
-0.010624295,
-0.019607719,
-0.019800762,
0.014974671,
0.013609577,
0.046413206,
0.005722365,
0.018270202,
0.032844998,
-0.004009103,
0.015112559,
-0.006539353,
0.014602372,
0.0075562797,
-0.02231033,
0.0009859015,
0.024006356,
-0.0032093506,
0.032486487,
0.015719268,
-0.02630909,
0.0122444825,
-0.03232102,
0.02701232,
-0.0018701103,
0.0120583335,
-0.010486406,
-0.00084327324,
0.0020821136,
-0.017429084,
0.004143544,
-0.013581999,
-0.0006157575,
-0.0030525026,
0.014809205,
0.007115037,
0.0018925171,
-0.0055672405,
-0.0015727886,
0.002793962,
0.010403673,
0.0240753,
0.011113798,
-0.0071426146,
0.0004774383,
-0.0023596138,
0.010224419,
-0.00054595154,
0.0130580235,
-0.022655051,
0.0092454115,
-0.014078397,
0.004570998,
0.012389265,
0.022820516,
0.00522252,
0.00469165,
0.039987613,
-0.012285849,
0.009217834,
-0.008707647,
-0.0025492103,
-0.014409329,
0.020131694,
0.0049674264,
0.032596797,
0.010900072,
-0.00979007,
0.029177168,
-0.014588584,
0.013189018,
-0.033093195,
0.022820516,
0.0159261,
-0.0094660325,
0.013471688,
0.008721436,
0.04109072,
0.00492606,
0.004957085,
0.0046675196,
0.0026457321,
-0.03303804,
0.01067945,
-0.0042883265,
0.018807966,
-0.0001954136,
-0.012885663,
0.0041469913,
0.01416113,
0.0071977703,
0.014657528,
-0.03223829,
-0.00696336,
0.0046399417,
0.005467272,
0.014864361,
0.00079975225,
0.0006101558,
-0.0026147072,
-0.041145872,
0.032072823,
0.022572318,
-0.01286498,
-0.0034644438,
-0.03389295,
0.011196531,
0.018863121,
0.02277915,
0.0048088552,
0.011961811,
0.003242099,
0.032045245,
-0.017029207,
-0.029535677,
0.022282751,
-0.025454182,
0.020352315,
-0.008142305,
0.018132314,
0.019924862,
-0.0073425528,
-0.007280503,
0.020379893,
0.0024802662,
0.0020993496,
0.009507399,
0.0016874083,
-0.032017667,
0.0050673955,
-0.004312457,
-0.000009553883,
-0.02254474,
-0.010224419,
-0.016353555,
-0.015402125,
-0.00749423,
0.0027405303,
0.00029258177,
-0.012347898,
-0.01127237,
-0.0114654135,
-0.008562865,
0.022903249,
0.034858167,
-0.015884735,
0.016036412,
0.01050709,
0.035685495,
0.0046296003,
-0.03833295,
0.0054155635,
-0.027191576,
0.014023242,
-0.010231313,
0.02054536,
0.0063600987,
0.0033179375,
0.022213807,
0.013195911,
-0.03731258,
-0.016932685,
-0.0014280059,
-0.010141686,
0.0059912475,
0.024406232,
0.025509339,
0.0072322423,
0.0034799564,
0.022034552,
0.012189327,
0.009066157,
-0.00825951,
-0.019607719,
0.013044234,
-0.007542491,
0.028460149,
0.014367962,
-0.047157805,
0.022875672,
-0.008473237,
0.0071426146,
-0.01374057,
-0.016450075,
0.0034454842,
0.01853219,
0.0028422228,
0.02890139,
-0.0062497878,
0.00891448,
0.018559767,
-0.01935952,
-0.002702611,
0.020186849,
-0.018132314,
-0.024916418,
-0.006532459,
0.012258272,
-0.015112559,
-0.007604541,
-0.02254474,
-0.033699904,
-0.021676043,
0.003978078,
-0.02396499,
0.022903249,
0.009645288,
0.009624604,
0.0031748784,
-0.0031024872,
-0.021221012,
-0.025536915,
-0.024709586,
0.0065910616,
-0.035713073,
-0.031466115,
-0.0025819587,
0.016960263,
0.014505851,
0.017484238,
0.0040677055,
-0.025936792,
-0.014423118,
-0.02087629,
-0.016270822,
0.014905727,
-0.032955308,
0.005536216,
-0.0092109395,
-0.0010591546,
-0.01078976,
-0.008418081,
0.011286159,
0.01374057,
-0.018049581,
0.020669458,
-0.00091006287,
-0.03505121,
0.025164617,
0.024985364,
0.024268344,
0.0014779904,
0.011051749,
-0.015540013,
-0.045999542,
-0.026047103,
-0.03563034,
-0.0015469346,
-0.018008213,
-0.008094044,
-0.001388363,
-0.0068220245,
-0.030886983,
0.021689832,
-0.013292434,
-0.0030628443,
0.0133338,
0.013416533,
0.0033386208,
0.008624914,
0.010644978,
-0.03008723,
-0.01356821,
-0.0013116626,
-0.034306612,
0.031548847,
0.0116515625,
-0.0072873975,
0.010017586,
0.018201258,
-0.037698664,
-0.016491443,
-0.009259201,
-0.012492682,
0.029645989,
-0.009093734,
-0.025302505,
-0.013485477,
-0.006532459,
-0.016698275,
-0.007183981,
-0.0039332644,
0.00015006127,
0.0006601403,
0.010796655,
0.011224109,
-0.006298049,
-0.008569758,
-0.02335828,
0.0016770667,
0.0037402206,
0.006118794,
-0.0013357931,
-0.019786973,
-0.013002868,
-0.023578903,
-0.01581579,
-0.02868077,
-0.023509959,
0.019428464,
0.0010962121,
0.02054536,
0.031024871,
0.034775432,
-0.011168954,
-0.001963185,
0.032045245,
0.006018825,
-0.0159261,
-0.0055982657,
0.005305253,
-0.01044504,
0.01993865,
0.003024925,
-0.021551944,
0.0023285889,
-0.012823613,
0.0083973985,
0.020117905,
-0.0059257504,
-0.019607719,
0.020283371,
-0.047378425,
-0.023937412,
0.009066157,
-0.012596098,
-0.018146103,
-0.026708966,
0.00076441834,
0.024875052,
-0.003016307,
0.026708966,
0.006466962,
0.0131269675,
-0.0037677982,
0.037119534,
-0.01712573,
0.03091456,
-0.03458239,
-0.0044951593,
-0.007880317,
-0.01044504,
0.020352315,
-0.004812302,
0.016119145,
-0.014285229,
-0.010962121,
-0.0024095983,
0.0013719888,
-0.009266095,
-0.022131074,
-0.01356821,
-0.017870326,
0.0028801423,
-0.00749423,
-0.000752784,
-0.025467971,
-0.007921684,
0.0040194443,
-0.011072432,
0.012940818,
-0.0052018366,
-0.004708886,
0.028653191,
0.017884115,
0.024957785,
-0.00010314692,
0.010162368,
0.0030352667,
0.0036574877,
-0.007604541,
-0.004991557,
0.005491402,
0.015733058,
0.019607719,
0.022834305,
-0.0187666,
-0.032100398,
0.008135411,
0.012940818,
-0.01339585,
-0.036843758,
0.012602992,
0.009597027,
0.009259201,
-0.015540013,
0.020945236,
-0.024654431,
0.034085993,
0.014043925,
0.017760014,
0.008362927,
-0.011748085,
-0.021303745,
0.010045164,
-0.008804169,
0.0124651035,
-0.03869146,
-0.021483,
-0.012520259,
-0.023799524,
-0.0018252966,
0.0053431722,
-0.011768768,
0.038967237,
-0.019097531,
-0.027467353,
0.0017356692,
-0.005787862,
-0.007015068,
-0.024957785,
0.005039818,
0.043931216,
-0.022020765,
-0.009955537,
0.013423428,
0.01675343,
0.0020907316,
0.014367962,
-0.007459758,
-0.010700134,
-0.023771945,
-0.0018976879,
-0.008369821,
0.025233561,
-0.0013728505,
-0.011899762,
-0.00919715,
0.0025216325,
-0.020007595,
-0.0043193516,
0.035326988,
-0.058078557,
-0.017663494,
-0.016091567,
0.0070012794,
0.033010464,
0.011368891,
-0.0009841778,
-0.0059878,
0.024516543,
-0.009921065,
0.004446898,
0.0052638864,
0.0016856847,
-0.023868468,
-0.0070564346,
0.009810754,
-0.0036195682,
0.013071813,
-0.025288718,
-0.0211107,
-0.0151263485,
-0.017870326,
0.007632118,
0.002976664,
-0.030831827,
0.023110082,
-0.008549076,
0.011472308,
0.0050329235,
-0.015774423,
0.021510577,
-0.011851501,
0.0049950043,
0.012830508,
-0.024613064,
-0.010300257,
-0.0055465577,
0.0006674656,
0.02406151,
-0.008948952,
0.0049364017,
0.0020252347,
-0.019180264,
-0.024585487,
0.0042366185,
-0.017566971,
-0.015415913,
-0.029508099,
0.022999771,
-0.00092816073,
-0.004705439,
-0.025123252,
0.014257652,
0.004591681,
0.018863121,
-0.0056672096,
0.0012875322,
-0.013843987,
-0.007659696,
-0.034665123,
-0.0045399726,
-0.0011961812,
0.032100398,
0.009645288,
-0.022668839,
-0.00016481963,
-0.011106904,
-0.025316294,
-0.007328764,
0.0066669,
0.019042376,
0.010638083,
0.02184151,
-0.015140137,
0.0071357205,
0.012651253,
0.01651902,
0.011817029,
-0.009927959,
0.009590132,
-0.0023751264,
0.024626853,
0.0007932887,
-0.04020823,
0.021276167,
0.010920755,
-0.006056744,
-0.023896046,
0.011341314,
0.025743749,
0.027743129,
0.0044710287,
0.016367342,
0.016257033,
0.014561006,
0.009293673,
-0.026488345,
-0.003816059,
0.017304983,
0.01570548,
-0.019621508,
0.0059946943,
-0.022131074,
-0.0004994142,
0.0018149549,
-0.011754979,
-0.037422888,
0.0240753,
-0.033451706,
0.032045245,
0.00042853103,
0.013361378,
0.0049329544,
0.004229724,
-0.001532284,
-0.0094315605,
-0.00914889,
-0.012010072,
-0.0022355143,
0.021772565,
-0.018022003,
-0.012561626,
-0.012016967,
0.021165857,
-0.012699514,
-0.011189637,
-0.0027301887,
-0.032762263,
-0.023137659,
0.04048401,
0.012768458,
0.006180844,
-0.0061153467,
-0.0020700484,
-0.027770707,
-0.007301186,
0.029645989,
-0.0034696148,
-0.014367962,
0.029452944,
-0.004591681,
-0.017553182,
-0.0051846006,
-0.003695407,
-0.00059636694,
-0.010865599,
0.015719268,
0.19480862,
-0.0025302507,
0.0129063465,
0.0038401897,
-0.0025509337,
-0.009438455,
0.016712064,
-0.0062118685,
-0.018807966,
0.0050122403,
0.01981455,
-0.011003488,
-0.01616051,
-0.0018459798,
0.020048961,
0.003242099,
-0.014340385,
0.004295221,
-0.021400267,
0.009314355,
0.017897904,
-0.0106863445,
-0.014602372,
-0.015305603,
0.022627473,
-0.0021131383,
-0.028570458,
-0.008817958,
0.004464134,
0.030611206,
-0.03149369,
-0.0005157885,
0.0059809056,
-0.0017011971,
0.010396779,
-0.0005127722,
-0.021303745,
-0.008383609,
-0.001571065,
0.005832676,
-0.003211074,
0.014243863,
-0.011789451,
-0.011217214,
-0.006067086,
-0.0028801423,
0.0005618949,
-0.004722675,
-0.00041495764,
0.008356032,
-0.043958794,
0.021744987,
0.00337654,
0.03317593,
-0.005639632,
-0.0032145213,
0.007411497,
0.0029973472,
-0.011044854,
0.0057913093,
-0.0054465886,
0.015429703,
-0.046468362,
0.012940818,
-0.024488965,
0.013320011,
-0.01734635,
0.0072184536,
0.03631978,
-0.01829778,
0.004274538,
0.0018252966,
-0.010486406,
0.00071486476,
-0.0028318814,
-0.024447598,
0.028377416,
-0.000020885233,
0.051184144,
0.021524366,
0.009990009,
-0.007763112,
-0.021510577,
-0.014071503,
0.014547218,
-0.026171202,
0.025123252,
0.010541562,
-0.019552562,
0.002188977,
-0.004626153,
0.0030232014,
-0.006129136,
0.0004373645,
-0.001427144,
0.0078044785,
-0.01759455,
0.01008653,
-0.0013952574,
-0.012403054,
-0.030142386,
0.07721746,
-0.020269582,
-0.0009126483,
-0.001057431,
0.011727401,
0.014381751,
0.022227596,
0.0015443491,
-0.0043055625,
0.018587345,
-0.023620268,
0.025164617,
-0.009293673,
0.00042896194,
0.011003488,
0.019538775,
-0.03389295,
0.044427615,
-0.006415254,
-0.006180844,
-0.011761873,
-0.021165857,
0.026267724,
-0.033148352,
-0.0059636696,
-0.008335349,
0.0044710287,
-0.014395541,
-0.020448837,
0.0030835276,
0.0010350242,
0.017649705,
-0.011113798,
0.002924956,
0.0035437297,
0.025647227,
0.000835517,
-0.026805488,
0.011568829,
0.002893931,
-0.0034627204,
0.0051673646,
0.005670657,
-0.010052058,
-0.015236659,
0.012816719,
0.007363236,
-0.014905727,
-0.018918278,
-0.013995664,
-0.026819278,
-0.012671936,
0.021331323,
-0.0021941478,
-0.014698895,
-0.027163997,
-0.03612674,
0.0028249868,
0.019566352,
-0.026970955,
0.004526184,
0.019014798,
0.006315285,
-0.005663763,
0.014381751,
-0.17528363,
0.012444421,
0.015912311,
-0.031217914,
0.029563256,
0.023647847,
0.028487725,
0.012285849,
-0.012175539,
0.024323499,
0.0043882956,
0.013519949,
-0.030721517,
-0.021772565,
-0.011079326,
0.00052569923,
0.008307771,
0.019373309,
0.022268962,
-0.0008251754,
0.0037333262,
-0.04412426,
0.01687753,
-0.007576963,
-0.0018046134,
0.0003369646,
-0.0073218695,
-0.0012711579,
-0.0009962431,
-0.007397708,
-0.0093833,
0.0057740733,
0.029287478,
-0.02477853,
-0.000053674103,
-0.0006536768,
-0.012030755,
0.011796345,
-0.003516152,
0.0026595208,
0.025454182,
0.0072667142,
0.011175848,
-0.024695797,
-0.00080363033,
0.016946474,
0.008487026,
-0.034416925,
0.019552562,
-0.0035109813,
0.0067909993,
-0.02031095,
0.01664312,
0.010376096,
0.016091567,
-0.016698275,
-0.010410568,
0.030997293,
-0.004626153,
-0.009631499,
-0.012685725,
-0.014836783,
0.049115818,
-0.006501434,
-0.009955537,
-0.02476474,
-0.022834305,
-0.0026526265,
-0.028570458,
0.015829578,
-0.0032834655,
-0.009397089,
0.009328145,
-0.014119764,
0.008480132,
0.0139060365,
-0.009507399,
0.01734635,
-0.018449457,
-0.005277675,
-0.004491712,
0.020986602,
-0.020559147,
-0.02819816,
0.0069116517,
-0.005108762,
-0.012409949,
0.021731198,
-0.013526844,
-0.008052678,
0.021938032,
-0.010672555,
0.014450695,
-0.01008653,
0.023537535,
0.024557909,
-0.009734915,
-0.018504612,
-0.0020114458,
0.00045632414,
-0.0023509958,
-0.014243863,
-0.02808785,
-0.0035919906,
0.05879558,
0.012189327,
-0.005984353,
0.002075219,
0.06624155,
0.006036061,
-0.021441633,
-0.0060153776,
-0.008473237,
0.020269582,
0.0031369592,
0.052232094,
-0.006701372,
0.01509877,
0.0013573382,
-0.015677901,
0.06701372,
0.008080255,
-0.022131074,
-0.009996903,
0.008590442,
-0.013368272,
-0.14208011,
-0.0024561356,
0.0134992665,
0.029563256,
-0.0052673337,
0.027591452,
0.0037195373,
0.018090947,
0.0001949827,
0.02997692,
-0.006763422,
-0.024861263,
0.0028232632,
-0.0092798835,
-0.01144473,
0.0045020534,
0.0029473628,
-0.008755908,
-0.008404293,
0.025936792,
-0.0007954432,
-0.0052500977,
0.0020252347,
-0.0013771595,
0.006618639,
-0.01745666,
-0.03907755,
0.012878769,
0.007721746,
0.010327835,
-0.0032903599,
-0.013051129,
0.013754359,
0.0034058413,
-0.03245891,
-0.038912084,
-0.0033437917,
-0.034775432,
0.039325748,
-0.006977149,
-0.010217524,
0.000953153,
0.026874432,
0.003398947,
0.016808586,
-0.011948023,
-0.0057637314,
0.0139060365,
0.00001652236,
0.013547527,
-0.040456433,
-0.010486406,
-0.042552333,
-0.0018511506,
0.023344493,
-0.02595058,
0.018118525,
0.011106904,
0.0046640723,
-0.017842747,
-0.007308081,
-0.011623985,
-0.019883495,
-0.0056223962,
0.025412817,
0.0012453039,
-0.0034782328,
-0.031328224,
0.02007654,
0.004322799,
-0.008452553,
-0.008121622,
-0.024819897,
-0.0004082787,
-0.017966848,
-0.0025991946,
-0.03245891,
-0.023289336,
0.024682008,
0.00094625854,
-0.0077837952,
-0.017401505,
0.027756918,
-0.040649474,
0.026626233,
-0.0054982966,
0.0011875632,
0.014202497,
0.016684486,
-0.01912511,
-0.00537075,
0.05145992,
-0.025192196,
-0.016022623,
-0.012720197,
0.022627473,
-0.013402744,
-0.000080793936,
0.02101418,
0.006466962,
-0.020862503,
-0.012851191,
-0.063649245,
0.019276787,
0.0052294144,
-0.00048605632,
-0.0042366185,
-0.009659076,
0.025826482,
-0.002188977,
0.0009962431,
-0.006170502,
-0.024047723,
0.024737164,
-0.01239616,
-0.039904878,
-0.03538214,
-0.027922384,
0.011782557,
-0.007363236,
0.022406852,
0.021276167,
-0.013547527,
0.0044331094,
0.015388336,
0.007928578,
0.0039849724,
-0.009059262,
-0.017608337,
0.026405612,
-0.022006975,
-0.023634057,
0.009486716,
-0.029094435,
-0.036650714,
-0.01758076,
0.0013685415,
-0.004946743,
-0.022034552,
0.0266676,
0.029287478,
0.014202497,
-0.035602763,
-0.04175258,
0.013175229,
0.015209082,
-0.002188977,
0.023509959,
-0.03245891,
0.008997212,
0.015884735,
-0.022255175,
0.027646607,
0.009831437,
-0.014781628,
-0.01616051,
-0.027812073,
-0.01651902,
-0.018008213,
-0.0077010626,
-0.003667829,
-0.033948105,
0.011527463,
0.028625615,
0.008183671,
0.016960263,
0.009238517,
-0.010334729,
-0.0062394463,
-0.025661016,
-0.0050984207,
-0.023578903,
-0.013175229,
0.0143128075,
0.019649085,
0.001579683,
-0.0014564453,
-0.017760014,
-0.027067477,
-0.0064187013,
-0.007028857,
0.007149509,
-0.00048864173,
-0.007301186,
-0.018794177,
0.019194053,
0.041118294,
-0.0031817728,
0.010879388,
0.018077157,
0.008804169,
0.011775662,
0.016601752,
0.018821755,
0.009872803,
0.022613684,
0.012368582,
0.018849332,
-0.025399027,
0.001301321,
0.014285229,
0.011927339,
0.0022268964,
-0.0030352667,
-0.0011530911,
-0.006208421,
-0.000018205566,
0.034665123,
0.0019183712,
-0.014188708,
0.007177087,
0.016422499,
0.029232323,
0.019235421,
0.025150828,
0.010251996,
0.009583238,
0.027991328,
-0.014340385,
-0.023082504,
-0.0120997,
0.0042641964,
0.026047103,
0.032596797,
-0.005487955,
0.0043365876,
0.03731258,
-0.0015770976,
0.034554813,
-0.011389575,
0.021207223,
-0.013189018,
0.039987613,
-0.00077217456,
-0.01946983,
-0.017856536,
-0.027122632,
-0.0017244658,
-0.015029826,
0.025426606,
-0.016946474,
0.086262934,
0.03538214,
-0.015953679,
0.015402125,
-0.027687974,
0.016670698,
0.003150748,
0.011761873,
-0.03116276,
-0.04757147,
0.02490263,
-0.017153306,
0.027881017,
-0.0017434254,
0.009045473,
0.015608957,
0.0077700065,
0.010748394,
-0.021317534,
-0.014878149,
0.0071977703,
-0.017622126,
-0.00058085454,
0.0039401585,
-0.026240146,
-0.0064910925,
0.0018287438,
-0.006797894,
0.006036061,
0.008569758,
0.020035172,
-0.007859634,
-0.021303745,
0.0004864872,
0.02819816,
0.0053259362,
-0.00026004875,
-0.007066776,
0.03196251,
0.027743129,
-0.0035575186,
-0.007935473,
-0.0027663843,
-0.02042126,
0.010127896,
0.0031404065,
0.012430632,
-0.016781008,
0.0021131383
] |
Physical activity induces a subclinical inflammatory response, mediated in part by leukocytes, and manifested by elevated concentrations of circulating proinflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α). However, the source of the cytokines that appear during exercise remains unknown. In this study, we examined exercise-induced changes in plasma cytokine concentrations and their corresponding mRNA expression in peripheral blood mononuclear cells. Ten healthy [peak oxygen uptake = 48.8 ± 6.5 (SD) ml · kg−1 · min−1] but | [
-0.015772572,
-0.019871878,
-0.019689687,
-0.03901499,
-0.018934894,
0.0114975795,
-0.02069174,
-0.0139636705,
-0.012922577,
-0.021915024,
0.0059505017,
0.015356134,
0.015941748,
0.008087997,
-0.014197917,
0.010248267,
0.03529308,
-0.0027800458,
-0.009395871,
-0.0035982805,
-0.027771179,
0.021420505,
0.0032582984,
-0.010371897,
-0.011972579,
0.021498587,
0.007743135,
-0.05382455,
-0.012506139,
-0.029801311,
0.01583764,
-0.00510136,
-0.003484411,
0.008074984,
-0.005781324,
-0.0028369806,
0.0025636936,
-0.010092103,
0.017984895,
0.0078342315,
0.023177352,
0.015928736,
-0.015759557,
-0.0108989505,
0.013404083,
-0.002539293,
0.026287619,
-0.004792285,
-0.0035852669,
0.03412185,
0.019624619,
-0.015382161,
0.014874628,
0.011009567,
-0.02686022,
-0.013495179,
0.001429064,
0.018102018,
-0.00575855,
-0.019858865,
-0.021602698,
-0.017737636,
-0.015746543,
0.008198614,
-0.011504087,
-0.006832178,
-0.0027800458,
0.03565746,
-0.010280802,
0.00041562418,
0.024999265,
0.050857432,
-0.008218135,
-0.00030927805,
0.010794842,
-0.017060924,
-0.01291607,
-0.0055275573,
0.003757698,
0.0040179715,
0.025311593,
-0.03433007,
0.0046263607,
0.025207484,
0.018232156,
-0.0063897134,
0.011588676,
0.011933538,
0.006022077,
-0.007593478,
0.015512298,
0.009799296,
0.015447229,
0.031545144,
-0.02214927,
0.023841048,
-0.010027035,
0.01892188,
-0.017555445,
-0.022448586,
-0.011432512,
-0.013599288,
0.0026547892,
-0.005384407,
-0.05699989,
-0.009096557,
-0.019091059,
-0.022409545,
0.013469151,
-0.009129091,
-0.013260933,
0.020223247,
-0.0034258494,
-0.04794237,
0.011979085,
-0.0031574424,
0.00014559047,
0.00050021306,
-0.016175995,
-0.024608856,
0.02112119,
0.031102678,
0.031623226,
0.00956505,
0.023190364,
0.010807855,
-0.0070599173,
0.002633642,
-0.02108215,
0.0008255549,
-0.013820521,
-0.006594679,
0.016956815,
0.0020821877,
-0.041305397,
0.004691429,
-0.0072290953,
-0.003975677,
-0.020925986,
-0.008764708,
-0.00370239,
0.014926683,
-0.0011012821,
-0.010027035,
0.012480112,
0.011770867,
0.042684846,
0.0070664245,
0.015629422,
0.0024237966,
-0.010352377,
-0.0040472522,
0.016345173,
-0.0026922035,
-0.02309927,
0.0026710564,
-0.027719123,
0.03008761,
-0.017906813,
-0.018700648,
0.014965723,
-0.021667765,
0.024608856,
-0.0017763664,
-0.0039268755,
0.015095861,
0.017178047,
0.014080794,
0.0056284135,
-0.00563492,
-0.0024059028,
0.02168078,
-0.012336962,
0.015928736,
0.0021749102,
0.037583485,
-0.0047955383,
0.01622805,
-0.0052445102,
-0.022760915,
-0.006012317,
0.024036253,
0.04284101,
-0.013352028,
0.005514544,
-0.0028288472,
0.03961362,
-0.02686022,
0.0073722457,
-0.012031141,
-0.0032029902,
0.018557498,
-0.017282158,
-0.03852047,
-0.6458946,
-0.011478059,
0.0014136102,
-0.000035050496,
0.017204076,
0.032924592,
0.008777723,
-0.015095861,
-0.022630777,
0.03950951,
0.010768814,
0.026704056,
0.010410938,
-0.018947907,
-0.0083938185,
-0.030608159,
-0.024752006,
-0.036646504,
0.006994849,
-0.0049647163,
0.0005530811,
-0.01672257,
0.009883884,
0.024400637,
-0.009636625,
0.03276843,
0.010476006,
-0.007593478,
0.009428406,
0.03794787,
-0.00011275127,
0.019494481,
0.028578026,
0.014289013,
0.050024558,
-0.021238314,
-0.017568458,
0.019052017,
0.02260475,
0.01873969,
-0.015798599,
-0.0070273834,
-0.00026027346,
0.010430459,
-0.02129037,
0.029697202,
0.009825323,
0.0089534065,
0.022396531,
-0.011783881,
0.015304079,
0.015798599,
-0.0040700263,
-0.003624308,
0.008797243,
-0.0007625199,
0.0005498277,
-0.003277819,
-0.00055877457,
0.0126557965,
-0.006074132,
0.022682833,
0.00006517003,
0.0037837254,
-0.0019585579,
0.012467098,
-0.019286264,
-0.014913669,
0.0014835587,
0.004372594,
0.040862933,
0.03430404,
0.0126557965,
-0.0032257643,
0.041045126,
0.016162982,
0.012063675,
-0.010404431,
-0.019533522,
0.012714358,
0.0032273908,
0.005836632,
-0.01583764,
0.0065751583,
0.022982147,
-0.0067866305,
-0.024686938,
0.026456797,
0.0037251639,
-0.0070989584,
0.027641041,
0.017568458,
-0.017763663,
-0.031987607,
-0.03459034,
0.036724586,
0.00056487473,
0.014093808,
0.022865023,
-0.0057357764,
-0.020626672,
0.025363648,
0.0073462185,
0.0049679694,
0.027146522,
0.004535265,
-0.036334176,
-0.013625315,
0.051820446,
-0.017620513,
0.013846548,
0.006357179,
-0.010248267,
-0.017282158,
-0.010996553,
-0.020379411,
0.007886286,
0.021069136,
0.00071656535,
-0.030139666,
0.017412294,
-0.017425308,
0.023320502,
0.0054657427,
0.011386964,
0.028421862,
-0.009272242,
-0.025962276,
-0.013234905,
-0.031232815,
0.006155467,
0.024465704,
0.028942408,
0.0037088967,
0.018375305,
-0.0049517024,
0.031232815,
0.02564995,
-0.0052868044,
-0.047760177,
-0.038051978,
-0.011211279,
0.007632519,
-0.014991751,
0.020965027,
-0.022656804,
-0.021888997,
0.01814106,
0.010879431,
0.017516404,
0.0039398894,
-0.0038943416,
-0.01548627,
-0.0007604865,
0.014406136,
-0.011979085,
-0.013872575,
-0.026092414,
-0.012968125,
-0.0014998257,
-0.012044154,
0.006432008,
0.009604091,
0.029202681,
-0.017464349,
-0.001199698,
-0.008068477,
0.012948604,
-0.0007072118,
-0.04000403,
0.013124289,
-0.006607692,
-0.022071188,
0.01480956,
0.011966072,
-0.01162121,
-0.016384214,
-0.0041253343,
-0.011543128,
-0.004993997,
-0.0027328713,
-0.019156126,
-0.0074243005,
-0.0068647126,
0.011432512,
0.020145165,
-0.0029264498,
0.027588986,
0.008816764,
0.03391363,
-0.011998606,
0.007710601,
-0.020561604,
0.014041753,
0.017204076,
-0.011367443,
-0.017060924,
0.00048963947,
0.025311593,
0.012499632,
0.009207173,
-0.011699292,
0.006620706,
-0.0031541889,
0.021602698,
-0.03341911,
-0.016735584,
-0.01470545,
0.037505403,
0.010358884,
0.0013070607,
0.013221892,
-0.006793137,
0.003037066,
-0.035241026,
0.0021781635,
0.0030842405,
-0.0017682328,
0.026756112,
-0.03433007,
0.012219839,
-0.010046556,
0.011803402,
-0.029176654,
-0.030009529,
0.025493786,
0.019637633,
0.026404742,
0.00083165505,
-0.00536814,
0.0038845814,
0.0007983075,
0.011211279,
-0.003952903,
0.013859562,
-0.0067475894,
-0.009226694,
-0.0066955346,
0.029931447,
0.019494481,
0.016735584,
0.013085248,
-0.005429955,
-0.036984857,
0.0009125838,
-0.0045482786,
0.020756807,
0.0011948178,
0.004769511,
0.014093808,
-0.0036373215,
-0.0015998684,
0.0014778653,
-0.006233549,
-0.028994463,
0.014197917,
-0.00041562418,
0.001215965,
0.037713625,
0.029124599,
0.02961912,
-0.0031606958,
0.011426005,
-0.004876874,
-0.012180798,
-0.00053559395,
0.007990395,
-0.014731478,
-0.0033705411,
0.0014746118,
-0.05046702,
0.002505132,
0.020886945,
-0.029072545,
0.019325305,
0.015147915,
0.020821877,
0.009057516,
0.033184867,
0.013521206,
0.0032550448,
-0.009486968,
0.007554437,
0.025415704,
0.00079790084,
-0.008419846,
-0.03469445,
-0.008302723,
-0.015655449,
0.008367792,
-0.012929084,
0.023008173,
-0.004756497,
0.0018739689,
-0.014289013,
0.01700887,
0.015850654,
-0.010521554,
0.02412735,
-0.01771161,
-0.005911461,
0.013547233,
-0.023164338,
-0.0011915644,
0.0324561,
0.036984857,
0.01480956,
-0.0062660836,
0.0065719048,
-0.037791707,
0.0019260236,
-0.00079017394,
-0.00997498,
-0.0059342347,
-0.0007190054,
0.0028207137,
0.00563492,
-0.006806151,
0.026222551,
-0.027536932,
-0.008836284,
-0.043101285,
-0.0076650535,
-0.025741044,
0.026235564,
0.013547233,
0.013072235,
0.015317093,
-0.014692437,
-0.0031216547,
-0.0049907435,
-0.028604053,
0.022474613,
-0.013625315,
-0.020353384,
-0.005436462,
0.0068712193,
0.0035982805,
-0.0043595806,
0.006682521,
0.011933538,
-0.039743755,
-0.015095861,
0.002706844,
0.017204076,
0.018049965,
0.013469151,
0.045157444,
0.034876645,
0.0069102603,
-0.0046946825,
0.020210234,
-0.00039163022,
-0.032117743,
-0.011816415,
0.022956118,
-0.0019601844,
-0.0029101826,
-0.0051306407,
0.0053095785,
-0.016670516,
0.021758862,
0.020912971,
-0.021602698,
0.026248578,
0.019481469,
0.012551688,
0.005647934,
-0.00715752,
-0.009604091,
-0.001468105,
0.003555986,
0.013924629,
-0.018401334,
0.03461637,
-0.015030792,
-0.005983036,
-0.036620475,
0.008497928,
-0.006689028,
-0.005781324,
-0.01587668,
-0.008972927,
-0.0076195053,
-0.011185252,
-0.011822922,
0.02951501,
-0.012584222,
-0.021173246,
-0.020743795,
0.015759557,
0.005277044,
0.0036991364,
0.0122458665,
-0.014041753,
-0.01367737,
-0.014510245,
0.00032900192,
0.015759557,
0.002645029,
0.021511601,
-0.020626672,
-0.0044962238,
0.020652698,
-0.026730085,
0.009675666,
-0.0011134824,
-0.019741742,
-0.00073120574,
-0.0021391225,
-0.015811613,
-0.013228399,
0.0026499091,
-0.016553393,
-0.005423448,
-0.023255434,
0.0025425463,
0.012870522,
-0.0014054767,
0.014132849,
0.013352028,
0.014588327,
0.004333553,
0.002762152,
-0.018128047,
-0.0242705,
0.0018821025,
0.0042847516,
-0.012584222,
-0.014119835,
0.012759906,
-0.00025193658,
0.007645533,
-0.008517449,
0.013560247,
0.0010711879,
0.011439018,
0.011556141,
0.022956118,
0.031154733,
0.0077366284,
-0.012851002,
0.03068624,
-0.009512994,
-0.011426005,
-0.004707696,
0.023658857,
-0.009701693,
-0.013612302,
-0.0069883424,
-0.01125032,
-0.023151323,
-0.021095164,
0.0120962085,
-0.013820521,
0.0145622995,
0.00091583724,
-0.031258844,
-0.031805415,
0.007203068,
0.0005087533,
0.029202681,
-0.009083544,
-0.01583764,
-0.032013636,
0.0048541,
-0.016631475,
-0.0029996515,
0.043777995,
-0.037661567,
-0.008686626,
0.00983183,
-0.024582827,
0.002438437,
-0.006929781,
-0.00069094467,
-0.014184903,
-0.0026238817,
-0.010970526,
-0.02309927,
-0.005849646,
-0.000703145,
0.038104035,
0.00802293,
0.024973238,
0.010794842,
0.012070182,
0.021993106,
-0.0120962085,
-0.00055714784,
-0.00909005,
-0.004327046,
-0.023372557,
-0.0014990125,
0.017165035,
-0.004662148,
0.027849259,
-0.034954727,
-0.014471204,
0.019598592,
-0.013234905,
-0.0005307138,
-0.009077037,
-0.022136258,
-0.003159069,
0.029801311,
-0.006607692,
0.011465046,
-0.028317751,
-0.0017812465,
0.031545144,
0.0010370271,
0.007717108,
-0.010085597,
0.01085991,
-0.017373253,
0.016384214,
-0.027927341,
-0.0050981063,
-0.018726675,
0.0020903212,
0.007248616,
0.011321896,
0.019572563,
-0.011016074,
0.0023148071,
-0.012538673,
0.022162285,
-0.023567762,
-0.0034095822,
-0.025103375,
-0.0123955235,
-0.026417756,
-0.015655449,
0.004450676,
0.00820512,
-0.009526009,
-0.019012976,
-0.009116078,
0.016514352,
-0.012480112,
0.01098354,
-0.0057520433,
-0.021771874,
0.024036253,
0.0005933421,
0.008530462,
-0.028005423,
0.032716375,
-0.013508192,
0.0018951161,
-0.004037492,
-0.0083547775,
-0.015134902,
0.014380109,
0.029593091,
0.011614703,
-0.022643792,
-0.007359232,
-0.001034587,
0.009174639,
-0.016032845,
-0.014262985,
0.033288974,
0.0027523919,
0.000031771662,
-0.01952051,
-0.0050005037,
-0.022097217,
0.023411598,
-0.010671211,
0.00791882,
0.014731478,
0.00081538793,
-0.0012151517,
0.019871878,
-0.018830784,
0.018479416,
-0.0067801233,
-0.02402324,
-0.013124289,
-0.0027540184,
-0.016891748,
-0.002025253,
0.009434912,
0.023320502,
-0.0014640382,
0.0060806386,
0.012180798,
-0.0068516987,
-0.0020350132,
0.018336264,
-0.010964019,
0.03844239,
-0.00600581,
0.0078342315,
0.0012818468,
-0.0064970762,
0.008777723,
-0.011861963,
-0.011471553,
-0.02250064,
-0.007743135,
0.0065881717,
0.032404047,
0.0044311555,
-0.009766761,
0.01009861,
-0.03747938,
-0.0054429686,
-0.02611844,
-0.011764361,
-0.0018446881,
-0.028473916,
0.0044213952,
0.00037454977,
0.02540269,
0.008569503,
0.026404742,
-0.0116862785,
-0.014991751,
0.024296528,
-0.022838995,
0.017724622,
-0.007866765,
0.0015014525,
0.004541772,
0.002677563,
-0.03872869,
-0.009701693,
0.023736939,
-0.010163679,
-0.025311593,
-0.002209071,
-0.009155119,
0.018010924,
0.0037154036,
-0.004053759,
0.030842405,
0.014887642,
0.0003810566,
-0.0015380535,
-0.024491733,
0.018804757,
-0.020249275,
-0.016345173,
0.04729169,
0.006838685,
0.009870871,
0.0028288472,
0.015655449,
0.016995857,
0.023749953,
-0.025207484,
-0.013033194,
0.01073628,
-0.017867772,
0.005179442,
-0.013273946,
0.0066564935,
-0.018752702,
0.01984585,
0.013443124,
-0.0009247841,
-0.012805454,
0.019559551,
0.008491421,
0.009434912,
-0.012610249,
0.0048020454,
0.016006818,
-0.017568458,
-0.012909563,
-0.00079342735,
0.0039008483,
0.02256571,
0.017919827,
-0.027432822,
-0.026092414,
-0.0035267053,
-0.047083467,
-0.021954065,
0.010872924,
-0.000006881742,
0.004261978,
0.019819824,
-0.034954727,
0.017334212,
0.0004888261,
0.022240367,
-0.027693097,
-0.03745335,
0.010846896,
-0.0005831752,
-0.0019878384,
0.0006592239,
-0.011998606,
-0.011738333,
0.04213827,
0.00070599176,
-0.014028739,
0.029306792,
-0.0023457145,
-0.0075219027,
-0.0139636705,
0.012577714,
-0.020808863,
0.021277355,
0.013378056,
-0.021394478,
0.004356327,
0.025246525,
0.0042034164,
0.0110876495,
0.01480956,
0.007326698,
0.0068972465,
-0.0066467333,
-0.015746543,
-0.0479684,
0.013872575,
-0.032195825,
0.029384874,
0.025207484,
-0.01353422,
0.007632519,
-0.0040277317,
-0.0056284135,
-0.027042411,
-0.005826872,
-0.018010924,
0.004782525,
0.008218135,
0.01431504,
-0.03128487,
0.013456138,
0.0043107793,
-0.00059456215,
-0.0064385147,
0.00021289555,
0.019208182,
-0.0066467333,
-0.00752841,
0.022188311,
-0.02073078,
0.0042424574,
0.002392889,
-0.011445525,
-0.013625315,
0.0030435727,
-0.011562648,
-0.0058561526,
-0.0022025642,
0.0049451957,
-0.0129941525,
-0.0013908363,
-0.016696543,
-0.020184206,
-0.028604053,
0.04325745,
0.19176948,
-0.0227479,
-0.009382858,
0.031909525,
0.0021781635,
-0.0017796197,
0.0035201984,
-0.011764361,
-0.02289105,
0.004327046,
0.022591736,
0.011113676,
-0.015082846,
-0.0015144661,
0.003438863,
0.0077756695,
-0.016358187,
0.011263334,
-0.012265387,
-0.0069037536,
-0.0028109534,
-0.0095520355,
0.00983183,
0.0036828695,
0.019025989,
0.008484915,
-0.0074633416,
0.01470545,
0.025897209,
-0.003943143,
-0.023554748,
0.02451776,
-0.010885937,
0.0018918627,
0.01601983,
0.02161571,
0.007593478,
-0.0037121503,
0.0063669393,
-0.009064023,
0.00056568807,
-0.018830784,
-0.037349243,
-0.019195167,
0.0012932337,
0.008751695,
-0.011224293,
-0.015642434,
-0.008771216,
-0.0014380108,
-0.04900949,
-0.02001503,
0.0112373065,
0.012460591,
0.010879431,
-0.0032143772,
0.024817074,
0.017399281,
0.013846548,
0.002197684,
-0.01007909,
0.0019927185,
-0.02951501,
0.019936947,
-0.028005423,
0.007124986,
-0.0257931,
-0.0015787212,
-0.012740386,
-0.020223247,
0.0035592394,
0.00498749,
0.010879431,
0.00473047,
-0.010196213,
-0.0011199892,
0.022370504,
0.0069883424,
0.0044929706,
0.017125994,
0.013586274,
0.009662652,
-0.011894497,
0.005983036,
-0.014523258,
-0.012024634,
0.017073939,
-0.008888339,
-0.039743755,
0.012935591,
0.003181843,
-0.03248213,
-0.009005462,
-0.020561604,
0.0042424574,
-0.027276658,
0.003858554,
-0.023463652,
-0.02143352,
-0.0015112128,
-0.022175299,
0.07350122,
-0.002353848,
0.0052933116,
-0.008361285,
0.0011069756,
0.008920873,
0.0026743098,
0.014471204,
-0.0010898951,
-0.0013461018,
-0.035475273,
0.011035594,
-0.014913669,
-0.011282855,
0.020392425,
-0.009766761,
-0.025350634,
0.020886945,
-0.012454085,
-0.0046458812,
-0.01125032,
0.0101506645,
0.012961618,
0.0018251676,
0.018414347,
-0.021030094,
0.002252992,
0.008530462,
-0.02834378,
0.013898603,
-0.010606144,
-0.014328054,
0.0058138585,
0.031232815,
0.00946094,
-0.008810257,
-0.023164338,
0.010586623,
0.015043805,
-0.014666409,
-0.032586236,
-0.004717456,
0.0017096712,
0.017581472,
-0.00037292307,
-0.0071900543,
0.01657942,
-0.031024596,
-0.0059082075,
-0.008725667,
-0.025910223,
-0.0014266239,
-0.011471553,
0.023854062,
-0.029775284,
-0.01647531,
-0.0089534065,
-0.022487627,
0.014575314,
-0.026261592,
0.03341911,
0.0013314614,
-0.01672257,
-0.016566405,
-0.005638174,
-0.16261886,
0.01764654,
0.025129402,
-0.015551339,
0.03284651,
0.016891748,
-0.00983183,
-0.00053600065,
-0.007678067,
-0.0040570125,
0.03719308,
-0.00045385183,
-0.024179405,
0.010924978,
0.0042847516,
0.0021293622,
0.0057097487,
0.028369807,
0.025610909,
0.019754754,
0.026599947,
-0.012675317,
0.010710252,
-0.026443783,
-0.008719161,
0.010606144,
0.0033298736,
0.00071005855,
0.0005831752,
-0.010593129,
-0.013794493,
0.017516404,
0.018752702,
-0.0098903915,
-0.00081213453,
-0.005901701,
0.008784229,
-0.03568349,
-0.0065784114,
0.01378148,
0.025220498,
0.009747241,
0.008862311,
-0.001202138,
-0.0065361173,
0.0076260124,
-0.012128743,
0.0030891206,
0.01110717,
-0.002739378,
0.013898603,
-0.022904065,
-0.0005010264,
0.015108874,
0.006012317,
0.008517449,
0.0064450214,
-0.007886286,
0.0058398857,
0.0037479377,
0.009753748,
-0.023697898,
0.032586236,
-0.008439367,
0.011009567,
0.0021326155,
0.015759557,
0.027771179,
-0.025142416,
0.00921368,
-0.0129941525,
-0.029801311,
0.01676161,
0.0047890316,
0.004333553,
-0.0034974245,
0.0010166932,
0.01061265,
-0.0015047059,
0.017958868,
-0.010261281,
0.013651343,
-0.031415004,
-0.012857509,
-0.026352687,
0.011465046,
0.008725667,
0.048384834,
-0.03638623,
-0.017373253,
0.0029508504,
-0.041227315,
0.0058919406,
0.002218831,
0.014458191,
0.008914365,
0.009662652,
0.0023180605,
-0.017282158,
-0.017490376,
0.024504745,
-0.03164925,
-0.00921368,
0.012200318,
0.022448586,
-0.0045547853,
-0.0012452458,
-0.008114025,
0.023320502,
-0.013417097,
-0.022682833,
0.005797591,
0.00498749,
0.036125954,
-0.003891088,
0.039821837,
0.012070182,
-0.01696983,
-0.000029001174,
-0.021160232,
0.06933685,
0.0047207098,
-0.017073939,
0.0137033975,
-0.009044503,
-0.02342461,
-0.12961619,
-0.019910919,
0.00013308514,
-0.0076260124,
0.018505443,
0.0119921,
-0.026808167,
0.027484877,
-0.0137033975,
0.01480956,
0.012415044,
0.018362293,
0.005703242,
-0.00048963947,
0.014692437,
-0.0083938185,
0.0006380766,
-0.022331463,
-0.023710912,
0.02834378,
-0.0024742244,
0.00027227044,
0.018830784,
0.0066630007,
-0.0023164337,
0.008211628,
-0.02990542,
0.022943106,
0.017386267,
0.01367737,
0.03649034,
0.012753399,
0.01126984,
-0.0022448585,
0.0062172823,
0.0012127117,
-0.013124289,
-0.037609514,
0.02774515,
-0.0016657502,
-0.004479957,
0.0055600917,
0.02285201,
-0.0056739612,
0.00793834,
-0.002566947,
-0.029983502,
-0.0024400637,
0.007951354,
-0.037375268,
-0.03932732,
-0.026170496,
-0.023437625,
-0.0049061547,
-0.0029719975,
0.029671174,
0.0036340682,
0.025415704,
-0.016605446,
0.0012761533,
-0.0007983075,
-0.0032127504,
-0.023060229,
0.02519447,
0.022878036,
-0.036958832,
-0.0047109495,
-0.011295868,
0.011426005,
-0.022643792,
0.0014892522,
-0.012968125,
-0.0050460515,
0.0017666061,
-0.005794338,
-0.0073397113,
-0.00216515,
-0.03344514,
0.0037154036,
0.0008426353,
-0.022461599,
-0.021954065,
-0.0008231148,
-0.018726675,
0.026222551,
0.023749953,
0.0039659166,
-0.011783881,
-0.00080603437,
0.023086255,
-0.025532827,
0.039951976,
0.01569449,
-0.013898603,
-0.014692437,
-0.0053388593,
-0.010241761,
-0.018466402,
0.012343469,
0.008933886,
-0.0056837215,
-0.014197917,
-0.042606764,
0.014874628,
0.00016287425,
0.0088427905,
-0.0009971727,
-0.032013636,
0.0024237966,
-0.006487316,
0.012467098,
0.018765716,
-0.025285566,
0.0036861228,
-0.003216004,
0.016839692,
-0.027588986,
-0.014145862,
0.010567103,
0.007209575,
0.010606144,
0.002218831,
0.00040952401,
0.0068582054,
0.0038292732,
0.009402378,
-0.013508192,
-0.008894845,
0.00473047,
0.015278052,
-0.028187616,
-0.013339015,
0.012818468,
-0.03893691,
-0.01190751,
0.007808204,
-0.017373253,
-0.016709555,
-0.010957512,
0.034095824,
0.00021818235,
0.019351332,
-0.007502382,
-0.023164338,
0.002147256,
-0.015278052,
-0.0040342384,
-0.00005063132,
-0.017581472,
0.00575855,
-0.0048573534,
0.002796313,
0.03461637,
0.007046904,
0.0048833806,
-0.045860182,
-0.011816415,
0.028786244,
0.009135598,
-0.0057487898,
0.007944847,
-0.017555445,
0.016644487,
0.011172238,
-0.004193656,
0.019559551,
0.019871878,
-0.0034063288,
-0.020769821,
-0.018023936,
0.016592434,
0.005023278,
0.002778419,
-0.00067630433,
0.0067085484,
-0.03029583,
0.011881484,
-0.0022481119,
-0.012356482,
0.015252025,
-0.0047955383,
0.00972772,
0.011386964,
0.009415392,
-0.029697202,
0.012532167,
0.039483484,
0.015395175,
-0.028213643,
0.029723229,
0.0046263607,
0.007391766,
-0.0016307759,
-0.006676014,
0.009701693,
-0.00022550255,
0.028604053,
0.015134902,
-0.0050948528,
0.0003615361,
0.0027442581,
0.031102678,
0.028499944,
-0.00033957552,
0.0046166005,
-0.03852047,
-0.007203068,
-0.017594486,
-0.04861908,
-0.035917737,
-0.041825943,
0.0023229406,
0.009857858,
0.02196708,
-0.017594486,
-0.0011598436,
-0.02469995,
0.013586274,
-0.022669818,
0.01534312,
-0.007320191,
0.023008173,
0.01859654,
0.01431504,
-0.0028223402,
0.00095243816,
0.010436965,
0.0023001668,
0.025610909,
0.01034587,
-0.003097254,
0.009369845,
0.026027346,
0.005836632,
-0.043673884,
-0.006754096,
-0.0037674583,
-0.013521206,
0.024283513,
0.017334212,
-0.0072290953,
0.065276586,
-0.00931779,
0.003562493,
0.017477363,
-0.009226694,
0.0045938264,
0.007352725,
0.025493786,
-0.007873272,
-0.037583485,
0.0024205432,
-0.02345064,
0.0022562456,
-0.07001356,
-0.028473916,
0.016813666,
0.00396917,
-0.005062319,
0.02186297,
-0.023411598,
0.015304079,
0.0022383516,
0.009883884,
0.011048608,
-0.03383555,
0.0055373176,
0.04336156,
-0.009096557,
-0.011406484,
-0.037427325,
0.0057390295,
-0.0037219105,
-0.041956082,
-0.024608856,
0.024986252,
-0.03755746,
-0.023008173,
-0.018661607,
0.0030565865,
0.00830923,
-0.010768814,
-0.005631667,
-0.025155429,
-0.0056576943,
-0.020899959,
-0.0151609285,
-0.028161587,
0.024595842,
-0.04323142
] |
Receptor tyrosine kinases are involved in regulation of key processes in endothelial biology, including proliferation, migration, and angiogenesis. It is now generally accepted that receptor tyrosine kinase signaling occurs intracellularly and on the plasma membrane, although many important details remain to be worked out. Endocytosis and subsequent intracellular trafficking spatiotemporally regulate receptor tyrosine kinase signaling, whereas signaling endosomes provide a platform for the compartmentalization of signaling events. This review summarizes recent advances in our understanding of endothelial receptor tyrosine kinase endocytosis and signaling using vascular endothelial growth factor receptor- | [
-0.033372283,
-0.02498439,
-0.010430438,
-0.031272106,
-0.006527828,
0.012460181,
-0.02164204,
0.003985849,
-0.04658801,
-0.014381072,
0.018171629,
-0.020323027,
-0.019541865,
0.00043700272,
-0.008522353,
-0.0007315394,
0.028224293,
-0.017454498,
-0.009322725,
0.009687694,
-0.011986361,
0.019413806,
-0.0017880294,
-0.014496325,
0.00019278943,
0.02230795,
0.017966734,
-0.048790634,
-0.0059099416,
-0.03186118,
-0.015559218,
0.009111427,
-0.018709479,
-0.0004994317,
0.017441692,
0.00088921253,
0.007798818,
-0.0051832045,
0.005573786,
0.021385921,
0.022064636,
0.0024699457,
-0.0041427216,
-0.01877351,
-0.0076899673,
-0.0051191747,
0.009425173,
-0.016775783,
-0.017774645,
0.029914677,
0.0050775553,
0.0021161817,
-0.00019008818,
-0.0042803856,
-0.013971281,
-0.007331401,
-0.004981511,
0.01864545,
0.013587103,
-0.025765553,
-0.0066270744,
-0.015059786,
-0.028506024,
-0.008829696,
0.0013382208,
0.012966015,
0.0030798288,
0.013190119,
-0.002082566,
0.003052616,
0.04072289,
0.0071969386,
-0.010340797,
0.017108737,
0.009149845,
-0.035882246,
-0.020182163,
-0.02050231,
-0.022179889,
0.008912935,
0.0056506214,
-0.016109873,
-0.025560658,
0.038340986,
0.010814616,
0.006226889,
-0.0028637284,
0.014214594,
0.008118967,
0.010327991,
0.0062044784,
0.014598772,
-0.009079412,
0.022218307,
-0.0018456562,
-0.011051527,
-0.0014230602,
0.027046146,
0.0025643897,
-0.04848329,
0.0052024135,
-0.0014518736,
0.009380352,
-0.018158823,
-0.04259256,
0.009738917,
0.000058277034,
-0.0010116693,
0.021590816,
-0.0062396945,
-0.025381375,
0.042976737,
0.00067871483,
-0.0049046753,
0.037393346,
0.0073249983,
0.025138061,
-0.0010524882,
-0.009156248,
-0.0073890276,
0.00338397,
0.014778055,
0.021654846,
-0.022039024,
0.042976737,
0.02312753,
0.012479389,
0.018338107,
-0.026329014,
0.0032719178,
-0.011672615,
0.015597636,
-0.0071585206,
0.009111427,
-0.02830113,
-0.0014062524,
-0.016980678,
0.000864401,
-0.020732818,
-0.04343775,
0.006281314,
0.020169357,
-0.022704933,
-0.0056250095,
-0.002487554,
0.015136622,
0.046127,
0.028096234,
0.028275518,
0.014201788,
0.014137759,
-0.005682636,
0.01327976,
-0.02054073,
0.000024799005,
0.009719709,
-0.018312495,
0.017736228,
0.013523073,
0.008202205,
0.020643177,
-0.014893309,
0.007088088,
0.013471849,
0.041337576,
0.0023434872,
-0.0002339085,
0.01959309,
0.0011549358,
-0.01826127,
-0.017800257,
0.020041296,
-0.016289156,
0.0053848983,
-0.008861711,
0.0042707813,
0.01722399,
0.016570887,
-0.031938016,
-0.011346064,
-0.015879367,
0.009297113,
0.018555809,
-0.0017095931,
-0.013395014,
-0.0017159961,
0.026841251,
-0.023383647,
0.013804804,
-0.012498599,
0.001110115,
0.01655808,
-0.012780329,
-0.0247923,
-0.63148654,
-0.023037888,
0.022832992,
-0.011013109,
0.013049253,
0.028710919,
0.014317041,
0.001735205,
-0.004072289,
0.022961052,
-0.022512844,
0.022410396,
-0.002942165,
-0.022909828,
-0.03616398,
-0.03444798,
-0.023678184,
-0.014573161,
0.027430326,
0.00310384,
-0.013023642,
-0.009514814,
0.0030125976,
0.02627779,
0.024945972,
0.019964462,
0.017608168,
-0.026687581,
-0.015367129,
0.039314236,
-0.014931727,
0.013702356,
0.011109154,
0.022218307,
0.043949988,
-0.0026748409,
-0.009681291,
0.038597107,
0.011896719,
0.052862924,
-0.007990907,
-0.0016871827,
0.040364325,
0.0053400774,
-0.022090247,
0.020745624,
0.012184853,
-0.0033039327,
-0.0067935516,
-0.008656816,
-0.0002619215,
-0.012620254,
-0.04218277,
-0.0074338485,
0.004984712,
0.005922748,
0.01877351,
0.0059611653,
-0.0014662802,
0.0082406225,
-0.0071969386,
0.030554974,
-0.012882777,
-0.033244222,
0.018658256,
0.017185573,
-0.010968288,
0.0009996637,
0.0037681481,
0.016967872,
0.026585134,
0.009918201,
0.021219444,
0.009386755,
0.0032575112,
0.031835567,
0.021962188,
0.025829582,
-0.020246193,
0.015136622,
-0.00092923106,
-0.010833826,
-0.024958778,
0.004209953,
0.017889898,
0.0150725925,
-0.01011029,
0.0097005,
0.015136622,
0.0042803856,
0.005224824,
-0.023037888,
-0.035344396,
-0.04476957,
-0.020412669,
0.03063181,
0.003444798,
0.020643177,
-0.004286789,
-0.009245889,
-0.020963324,
-0.006928014,
-0.008086951,
-0.004209953,
-0.0038705955,
-0.008541563,
-0.046101388,
0.0047862204,
0.048432067,
-0.025010003,
0.012165643,
-0.020258998,
-0.000009079212,
-0.008784875,
-0.011781465,
-0.021462757,
0.013638327,
0.024651436,
0.018274078,
-0.015239069,
-0.0032238956,
-0.013190119,
0.010238349,
0.0020201372,
0.014022505,
0.026482685,
-0.005692241,
-0.018158823,
-0.010449648,
0.0032335,
-0.013036448,
-0.02627779,
0.017966734,
-0.004136319,
0.021565204,
0.00411711,
0.03391013,
0.008573578,
0.0040402743,
-0.03227097,
-0.00019258934,
-0.014368266,
0.008503145,
-0.0033263431,
0.005922748,
-0.0057786806,
-0.0056314124,
0.0049174814,
-0.00032835233,
-0.017531333,
-0.00888092,
-0.012216867,
-0.0068063573,
0.011218004,
0.0069728345,
-0.016506858,
-0.02485633,
-0.009822156,
0.0016759775,
-0.00411711,
-0.0035536485,
0.0013654334,
-0.03467849,
0.016583692,
-0.008138175,
-0.010917065,
0.0026380238,
0.0026764416,
0.012088808,
-0.03690672,
0.0019224918,
-0.004193946,
-0.032706372,
0.021910964,
0.0034864172,
0.017492915,
-0.0010628931,
-0.0065630446,
0.0046933773,
-0.007715579,
0.004507691,
-0.036010306,
-0.023716602,
-0.0014574762,
0.011454914,
0.014714026,
0.019887626,
0.03767508,
0.013036448,
0.02526612,
-0.03716284,
0.0076643554,
-0.026918087,
0.02123225,
0.01127563,
-0.03946791,
0.013395014,
0.015533606,
-0.01735205,
0.026508298,
0.025944836,
-0.021309085,
0.020323027,
-0.002929359,
-0.0062460974,
0.00799731,
-0.006575851,
-0.022295143,
0.021065772,
0.021923771,
0.007145715,
0.03116966,
-0.01646844,
0.0015695281,
0.010052663,
0.014662802,
-0.004309199,
0.005945158,
-0.019785179,
-0.019093657,
-0.0068255663,
-0.019221717,
0.012863567,
-0.009521217,
-0.010443245,
0.02312753,
0.011301243,
0.018632643,
-0.004546109,
-0.021052966,
-0.025419792,
0.012594643,
0.014086535,
0.009694097,
-0.015149428,
0.01879912,
0.005042339,
-0.004606937,
0.018069182,
0.02485633,
0.040799726,
0.002213827,
-0.0069728345,
0.012857164,
-0.01653247,
0.0050519435,
0.021270668,
0.026213761,
-0.01845336,
0.013241342,
0.022474427,
0.021245055,
-0.018197242,
-0.016852617,
0.006537433,
-0.008285443,
0.020950519,
0.0048470483,
0.030119572,
0.012895582,
-0.00034896188,
0.002860527,
0.0031390563,
-0.023614155,
0.008810488,
0.042029098,
0.017275214,
-0.0063837613,
-0.00898977,
0.013920058,
-0.011602182,
-0.013010835,
0.0046421536,
-0.016660528,
0.008022922,
0.009578844,
0.02151398,
-0.012095211,
0.000031014388,
0.017953929,
-0.0019753163,
-0.022410396,
0.033013716,
0.02707176,
-0.0035056262,
-0.021116996,
-0.013497462,
-0.0042323633,
-0.0034960217,
0.021373115,
0.013727969,
-0.0011677417,
0.0063325376,
-0.006281314,
-0.030401303,
-0.00853516,
0.04126074,
-0.011480526,
0.015507994,
-0.009476396,
0.026457073,
-0.0090538,
-0.0061916723,
0.0007251364,
0.04564037,
0.0035248352,
0.0082406225,
-0.00564742,
-0.012556225,
-0.024152003,
0.0017832272,
-0.016711753,
0.00031074416,
-0.06151974,
-0.008419906,
-0.0021033757,
0.008227817,
-0.008765667,
0.01511101,
-0.016212322,
-0.018248465,
-0.028787754,
-0.0070752823,
-0.012152838,
0.04407805,
0.021757293,
0.00663988,
0.029171932,
-0.016417217,
-0.010321588,
-0.0295305,
-0.011903122,
0.0026604342,
-0.016097067,
0.0013854427,
-0.008944949,
-0.00035276366,
0.0012173647,
0.025189286,
0.017480109,
-0.019324165,
-0.023229977,
0.014381072,
-0.03078548,
0.014060923,
-0.010635334,
0.019964462,
0.010071873,
0.0256503,
-0.004837444,
0.009642873,
0.025496628,
0.023780633,
-0.02403675,
0.009783738,
0.020835266,
-0.005794688,
-0.018491779,
-0.03798242,
-0.03508828,
-0.0017592161,
0.010910662,
0.0077604,
0.020451088,
0.011102751,
0.022295143,
0.022423202,
-0.002606009,
-0.024689853,
-0.012716299,
0.01052008,
-0.008579981,
0.0021321892,
-0.011781465,
0.012818746,
-0.013689551,
-0.0057818824,
-0.023191558,
0.0011485328,
0.0011717436,
0.022512844,
-0.013151702,
-0.007581117,
-0.0038001628,
0.005951561,
-0.014931727,
0.001511101,
-0.02110419,
0.004193946,
0.006156456,
-0.002978982,
-0.0168142,
-0.011077139,
0.00095484295,
0.0058971355,
-0.038776387,
-0.016212322,
-0.0005486545,
0.011486929,
0.01735205,
0.00007548502,
0.0017111938,
-0.00788846,
0.030452527,
-0.0070688794,
-0.0030894333,
-0.019490642,
-0.035165112,
-0.01981079,
0.0002709257,
0.0072545656,
-0.017428886,
0.0035536485,
-0.0070688794,
0.023306811,
-0.01375358,
0.013599909,
-0.019580284,
0.0057818824,
0.009341934,
0.019247329,
-0.0035056262,
-0.006012389,
0.0012645867,
-0.016865423,
-0.009995037,
-0.008509547,
0.0028493218,
-0.017851481,
-0.004744601,
0.005471338,
-0.0043252064,
-0.02681564,
0.009425173,
0.0026540312,
-0.023050694,
-0.0063037244,
0.0057690763,
0.009854171,
0.015956203,
0.020130938,
0.026866864,
0.011243616,
0.0059163445,
-0.010859437,
-0.0034415966,
0.027122982,
-0.006281314,
-0.02009252,
0.018491779,
0.002959773,
0.0009252292,
-0.006015591,
0.00008088753,
-0.013907252,
0.033884518,
0.0015103007,
-0.019644313,
-0.01675017,
-0.0038737971,
-0.021283474,
-0.006182068,
0.0066142683,
-0.0074082366,
-0.01829969,
0.015226264,
0.008669622,
0.00022350368,
0.008701636,
-0.03798242,
-0.01836372,
0.011205198,
-0.014957339,
0.008144578,
-0.0027820906,
-0.0065342314,
-0.017659392,
-0.022179889,
-0.027840115,
-0.064593166,
-0.02707176,
-0.013215731,
0.023588542,
0.0472027,
0.011672615,
-0.00024691454,
0.024484958,
0.0025227703,
-0.00044660718,
-0.0010396823,
-0.016109873,
0.009745321,
-0.044692732,
0.0053080623,
0.00827904,
0.004241968,
0.025010003,
-0.009354739,
0.010123096,
0.013945669,
0.00004497086,
0.0028429187,
0.0063517466,
-0.034755323,
-0.019221717,
0.04779177,
-0.026585134,
-0.0024123192,
-0.03552368,
0.006742328,
0.009815753,
0.0019320963,
0.006620671,
0.0044756765,
0.008919338,
-0.03403819,
0.027609607,
-0.013023642,
0.0010300778,
0.008720846,
-0.021526786,
-0.0030462132,
-0.012184853,
0.034652874,
0.004875862,
0.0005522562,
-0.0012958011,
0.013292567,
-0.019618701,
-0.011608585,
-0.010507274,
-0.01655808,
0.0037073197,
-0.0031934814,
-0.01778745,
-0.009361142,
-0.019183299,
-0.04697219,
-0.009092218,
0.016865423,
-0.00829825,
0.0056314124,
-0.00853516,
0.004434057,
0.032603923,
-0.0051896074,
0.021629233,
-0.022948246,
0.024305675,
0.02356293,
0.014995757,
-0.012703493,
-0.01340782,
-0.008259832,
0.009726112,
0.049994394,
0.021629233,
-0.0024651436,
-0.013894445,
-0.0005334475,
0.014521937,
-0.011089944,
-0.035293173,
0.022679321,
-0.007830833,
-0.003345552,
-0.009405963,
-0.0019881222,
-0.008919338,
0.014752444,
-0.011089944,
0.00090762106,
-0.00077355886,
-0.01269709,
-0.024971584,
0.054553308,
-0.0013950472,
0.028454801,
0.0055257636,
-0.033833295,
-0.014265818,
0.016762976,
-0.009898992,
-0.0072865803,
-0.010488065,
0.013689551,
-0.010372812,
0.008106161,
0.034652874,
0.0047157877,
0.009130635,
-0.020489505,
0.0029069486,
0.042438887,
-0.00056386157,
-0.0035184321,
0.03186118,
-0.014457907,
-0.0048982725,
0.009207471,
-0.0051896074,
-0.014048117,
-0.024958778,
-0.011102751,
0.019797985,
0.023614155,
-0.0072353566,
-0.0016087462,
-0.025010003,
-0.019977268,
-0.024933167,
-0.014918921,
0.004017864,
-0.03618959,
-0.01584095,
0.0025707926,
0.011442108,
0.035907857,
0.008573578,
0.02002849,
0.002817307,
0.03611275,
-0.009841366,
0.0155208,
0.007542699,
-0.005147988,
-0.012434568,
0.0015615243,
-0.017902706,
-0.030478138,
0.026994923,
-0.008394294,
-0.020924907,
0.013081268,
-0.007766803,
0.015751308,
0.0033679623,
-0.018005153,
0.0058170985,
-0.011582973,
0.011025915,
0.005996382,
-0.009649277,
0.011352466,
-0.019631507,
0.0012509803,
0.0060828216,
-0.027865727,
-0.009309919,
0.01864545,
-0.009969424,
-0.003928222,
0.010084678,
-0.016109873,
-0.019836402,
-0.0055577783,
-0.033807684,
0.007593923,
0.002735669,
-0.00877207,
-0.012319315,
0.007792415,
0.0073698186,
-0.011422899,
-0.011493332,
0.005657024,
-0.01174945,
0.013548685,
0.0019977267,
0.007862847,
0.005996382,
-0.016801395,
-0.011422899,
0.006076419,
-0.025970448,
0.035037052,
0.007568311,
-0.008957756,
-0.021501174,
-0.014317041,
-0.07120103,
-0.023076305,
-0.0065502385,
0.010488065,
-0.0047542057,
0.006831969,
-0.0037969614,
-0.0027084565,
-0.0035344397,
0.0154951885,
0.0007175329,
-0.02078404,
0.028634083,
-0.016353186,
0.011083541,
0.0017544138,
-0.03511389,
-0.029735394,
0.03447359,
-0.03649693,
-0.0038385808,
0.017736228,
-0.01052008,
0.014035311,
-0.001560724,
-0.005528965,
0.0062941196,
0.038750775,
0.03798242,
-0.02362696,
0.005951561,
0.026918087,
0.007741191,
-0.030657422,
0.0026892475,
-0.0026540312,
0.021475563,
0.0070176553,
-0.0064317835,
-0.0049591004,
0.01653247,
0.0048406455,
0.02006691,
0.031374555,
-0.008157385,
0.015482382,
0.009175456,
0.0011789469,
-0.009995037,
-0.011890316,
-0.023780633,
0.015674472,
-0.012505001,
0.008509547,
-0.0010332793,
0.002511565,
-0.011775062,
-0.016916648,
-0.0018312496,
0.03262954,
-0.006345344,
-0.019042434,
-0.0065438356,
0.020591952,
-0.022359172,
-0.0035920665,
-0.0000015335239,
-0.012319315,
-0.034857772,
-0.020130938,
0.012351329,
-0.010276767,
-0.029018262,
-0.006831969,
0.0028765344,
0.0070944913,
0.0014958939,
-0.010942676,
-0.02407517,
0.013292567,
0.18102477,
-0.018978404,
0.0014598772,
0.0019433015,
0.0026268186,
-0.016071456,
0.016045844,
-0.0030606198,
-0.004600534,
-0.008368682,
0.011570168,
0.015648859,
-0.0039122147,
-0.008810488,
0.0076643554,
-0.010065469,
-0.029889066,
-0.009822156,
-0.012306509,
0.009783738,
0.0031134444,
-0.02034864,
0.018402137,
-0.014534743,
0.047177084,
-0.0024043154,
-0.024433734,
0.016545275,
0.028352352,
0.0074594603,
-0.0295305,
0.008375085,
0.015443965,
0.008746457,
0.011499735,
0.0064766044,
-0.00043700272,
-0.009271501,
0.030247632,
0.0065886565,
0.004751004,
0.0027068558,
-0.007312192,
-0.009073009,
-0.0030462132,
0.027327877,
-0.016660528,
-0.010385618,
-0.01879912,
-0.015405547,
-0.05557778,
0.010686558,
0.0033295446,
0.005019929,
-0.016993484,
-0.012569031,
0.006428582,
0.028070621,
-0.0048406455,
-0.0019192904,
-0.027020535,
-0.010673751,
-0.015943397,
-0.011358869,
-0.02681564,
0.028019398,
-0.007971698,
-0.008701636,
0.024395317,
-0.010801811,
-0.012095211,
0.016378798,
-0.0032078882,
-0.0072481623,
-0.010123096,
-0.0050167274,
0.01858142,
0.0025916023,
0.03606153,
0.0044468627,
-0.0019401,
0.01886315,
-0.018888762,
0.0029357618,
-0.008746457,
-0.017364856,
0.011653406,
0.01030238,
-0.0030878324,
0.023383647,
0.004302796,
0.003963439,
-0.020041296,
-0.010488065,
0.023447677,
-0.02183413,
-0.010167917,
-0.0065534404,
-0.002493957,
-0.002636423,
-0.022205502,
0.08313616,
0.031425778,
0.009585246,
-0.01092987,
0.008970561,
-0.017723422,
0.012812343,
-0.0048790635,
-0.02356293,
0.0018600629,
-0.017723422,
0.012537016,
0.0017063916,
-0.016660528,
0.00029093496,
0.028224293,
-0.012242479,
0.03606153,
-0.006150053,
-0.02463863,
-0.013420626,
0.0025675911,
0.019170493,
-0.015648859,
0.022295143,
-0.01883754,
0.009175456,
0.0017752235,
-0.019990074,
-0.00045821257,
0.025381375,
0.0010869042,
0.024715466,
0.020899296,
-0.024869137,
0.02312753,
-0.0015631252,
-0.024702659,
0.027481548,
0.015123816,
-0.001834451,
0.022576874,
0.025227703,
0.0021802115,
-0.003544044,
0.011256422,
0.011301243,
-0.036343258,
0.003675305,
-0.0058619194,
-0.015572024,
-0.0019929246,
-0.0043828334,
0.02246162,
-0.014201788,
-0.005609002,
-0.023614155,
0.017518526,
0.013523073,
-0.03075987,
0.0032046866,
0.0012469785,
-0.03257831,
-0.006921611,
0.020553535,
-0.15797408,
0.017813064,
0.018197242,
-0.018197242,
0.03050375,
0.021116996,
-0.0017928317,
0.007773206,
-0.017620975,
0.0063517466,
0.05145427,
0.00027432726,
-0.055987574,
-0.031400166,
0.02239759,
0.0030302056,
-0.005048742,
0.014982951,
0.0058299047,
0.013254149,
0.019823596,
-0.028019398,
0.02009252,
-0.016327575,
-0.0016071455,
0.0040786923,
-0.0005718653,
-0.032424644,
-0.004389236,
-0.00032214946,
-0.004046677,
0.007152118,
0.03910934,
-0.00061548554,
0.015200651,
-0.0027564787,
0.018440554,
-0.009130635,
-0.0025964044,
0.02151398,
0.036676213,
0.010500872,
-0.012370539,
0.010782602,
-0.014931727,
0.017198378,
-0.0046869745,
0.005192809,
0.02075843,
-0.012767523,
0.016225128,
0.0051447866,
-0.02022058,
0.01778745,
0.034089413,
0.02545821,
-0.022858605,
0.009073009,
0.006070016,
-0.023037888,
-0.003457604,
0.011006706,
0.017441692,
-0.018965598,
-0.005801091,
-0.014982951,
-0.011262825,
-0.018338107,
-0.02054073,
0.006479806,
-0.027532773,
-0.006537433,
0.006012389,
-0.013945669,
0.0065886565,
0.017159961,
-0.0084071,
0.011224407,
-0.0011933536,
-0.014214594,
-0.0014998958,
0.0041075055,
-0.016788589,
-0.021193832,
-0.014611579,
0.005919546,
0.011871107,
0.008522353,
0.016045844,
-0.01151254,
0.03918618,
-0.03839221,
0.01304285,
-0.004193946,
0.030734258,
0.010180723,
0.0072033415,
-0.01075699,
-0.010078276,
0.0047285934,
0.033013716,
-0.008855308,
0.000381577,
-0.0026444267,
0.023268394,
0.0058042924,
0.008592786,
0.01116678,
0.036445707,
-0.009514814,
-0.013625521,
-0.02078404,
-0.007830833,
0.012229674,
-0.012492195,
0.030836705,
0.002394711,
0.007613132,
0.0051383837,
-0.026610745,
0.062646665,
-0.0025579866,
0.009630067,
0.044026826,
-0.002183413,
-0.043821927,
-0.12580556,
-0.023550125,
0.0232812,
0.0039122147,
0.01000144,
0.0062396945,
0.004507691,
0.020182163,
0.014253012,
0.022474427,
-0.049097978,
-0.0012237678,
-0.007805221,
-0.01709593,
0.015213458,
-0.0028669299,
0.024062363,
-0.021936577,
-0.03447359,
0.035779797,
-0.012921195,
-0.0070176553,
-0.007100894,
0.014457907,
-0.008266235,
0.01707032,
-0.030324468,
-0.0020201372,
-0.0052824505,
-0.00070112525,
0.02226953,
0.010059066,
0.03227097,
-0.009822156,
-0.014739637,
-0.00022910628,
0.0042195576,
-0.015443965,
0.028249905,
0.001448672,
0.0030542167,
0.008029325,
0.037239674,
0.0032911268,
-0.027968174,
0.0040594833,
-0.038699552,
0.00007773606,
0.019964462,
-0.032373417,
-0.034908995,
-0.03227097,
-0.02886459,
-0.014752444,
0.019605896,
-0.011128362,
-0.018030765,
0.012671478,
-0.0070048496,
0.010667348,
-0.0014494724,
0.005922748,
0.018952793,
0.008387892,
0.007100894,
-0.02054073,
-0.009233084,
-0.040927786,
0.028454801,
-0.0027164603,
0.008592786,
-0.0013830416,
-0.009668485,
-0.007792415,
-0.02157801,
-0.0049398914,
0.0023963116,
0.0010332793,
0.00963647,
-0.010942676,
-0.02097613,
-0.022909828,
0.004709385,
-0.0014286628,
0.011096348,
0.015764114,
0.006748731,
-0.01709593,
0.013420626,
-0.02552224,
-0.0057114493,
0.02381905,
-0.005785084,
0.0038737971,
0.006831969,
0.0028125048,
0.00037777526,
-0.01174945,
0.015956203,
0.018146018,
-0.014060923,
0.0037841555,
-0.056448586,
0.007613132,
0.015482382,
-0.0056250095,
0.023793438,
-0.0026716394,
0.0045685195,
-0.010116694,
0.00663988,
0.014048117,
-0.001586336,
0.011826286,
0.010692961,
0.005103167,
-0.027122982,
-0.009860574,
0.03457604,
-0.004193946,
0.0023242782,
0.04602455,
-0.00597077,
0.002082566,
0.026431462,
0.012043987,
0.0035920665,
0.005996382,
-0.017518526,
-0.0016471641,
-0.016622111,
-0.010103887,
0.011339661,
-0.035856634,
-0.0012629859,
-0.017749034,
0.00034215872,
-0.0036144766,
-0.015943397,
0.03618959,
0.017800257,
0.028403576,
-0.015917784,
-0.025816776,
0.007292983,
-0.011454914,
-0.0003735733,
-0.005231227,
-0.027968174,
-0.013305373,
-0.009040995,
-0.008874517,
0.011755854,
0.01612268,
-0.01899121,
-0.007965295,
-0.008951353,
-0.014790862,
0.011986361,
-0.004808631,
-0.016506858,
-0.042131543,
0.035318784,
0.013740774,
-0.004949496,
0.010187126,
0.014752444,
-0.015687278,
-0.055731453,
0.007171327,
0.030375691,
-0.031477,
-0.030529363,
0.0031118435,
0.016225128,
0.0030141983,
0.0002569192,
0.011160377,
-0.008054936,
-0.0026092103,
-0.022320755,
0.023870273,
0.025957642,
-0.002810904,
-0.007421043,
0.0029005455,
0.013292567,
0.012690688,
0.010462454,
0.027046146,
0.015507994,
0.00198332,
-0.0063837613,
0.016660528,
0.009437978,
0.012857164,
0.018338107,
0.025342956,
-0.0037553422,
0.009886187,
0.012440971,
0.047049027,
0.02606009,
-0.009258695,
-0.007126506,
-0.027865727,
-0.011762257,
0.027302265,
-0.03186118,
-0.0316819,
-0.047407594,
-0.0010492868,
-0.0004522098,
0.0018760703,
0.02129628,
-0.013087671,
-0.018952793,
0.0074082366,
-0.0020553535,
-0.013305373,
-0.008093354,
0.033858906,
-0.0030430118,
0.01612268,
-0.015213458,
-0.018683868,
0.011621391,
-0.008138175,
0.016903842,
-0.008067743,
0.01769781,
-0.0011261224,
-0.002742072,
-0.0047478024,
-0.0044660717,
-0.00051703985,
-0.011442108,
-0.028429188,
0.0011141169,
0.0037649465,
-0.012043987,
0.08180435,
0.0010300778,
-0.008074146,
-0.008099757,
0.0036592975,
0.038340986,
0.0005522562,
0.033346668,
-0.055833902,
-0.044282943,
-0.014483519,
-0.015213458,
0.017249603,
-0.03718845,
-0.011570168,
0.013804804,
0.00564742,
0.0048150336,
0.011691824,
-0.0020761632,
-0.008483936,
-0.026380237,
0.0021562004,
0.023895886,
-0.02612412,
0.012076002,
0.04195226,
-0.0012950008,
-0.009348337,
-0.033807684,
-0.0011701428,
-0.012242479,
-0.031425778,
0.0019160889,
-0.012729105,
-0.020924907,
-0.019823596,
-0.015828142,
0.011435705,
0.030683033,
-0.0029565715,
-0.008611995,
-0.031886794,
-0.040799726,
0.009450784,
-0.012607449,
-0.03265515,
0.0037041183,
-0.00038577896
] |
OBJECTIVES To determine the incidence and clinical importance of errors in the preparation and administration of intravenous drugs and the stages of the process in which errors occur. DESIGN Prospective ethnographic study using disguised observation. PARTICIPANTS Nurses who prepared and administered intravenous drugs. SETTING 10 wards in a teaching and non-teaching hospital in the United Kingdom. MAIN OUTCOME MEASURES Number, type, and clinical importance of errors. RESULTS 249 errors were identified. At least one error occurred in 212 out of 430 intravenous drug doses (49%, 95% confidence interval 45% to 54%). Three doses ( | [
-0.009009982,
-0.0011444397,
0.0030595572,
-0.028207462,
0.0013875505,
0.028577916,
0.011695777,
0.01280714,
-0.02279618,
0.0038930797,
-0.008295534,
-0.007845697,
-0.017543666,
0.010908562,
-0.0036780837,
0.007680315,
0.031091714,
0.0058214273,
0.0009765775,
-0.019118097,
-0.038024507,
0.028260384,
-0.0075810864,
0.018271344,
-0.016286766,
-0.0068930993,
0.012390379,
-0.025918582,
-0.006512722,
-0.006496184,
-0.013296669,
-0.028789606,
-0.015506166,
-0.024833681,
-0.0040353076,
-0.02611704,
-0.008619682,
-0.025296748,
0.0038963873,
-0.0133760525,
0.018906409,
0.016167691,
0.013276824,
-0.0022012272,
0.009929503,
0.018800564,
0.009373821,
0.008368302,
-0.020136846,
0.009618586,
0.03220308,
0.019634087,
-0.0027701396,
0.0017199672,
0.025693664,
-0.02017654,
-0.0008306284,
0.012251459,
0.017543666,
-0.02074545,
-0.0126748355,
-0.0072040167,
-0.02916006,
-0.0015091059,
-0.041940738,
-0.00084303203,
-0.017451052,
0.006512722,
0.008745371,
-0.0021466515,
0.02791639,
0.02507183,
-0.0065259524,
-0.0143021885,
0.030297885,
0.010280112,
-0.010108115,
-0.014183114,
0.013051905,
0.02788993,
0.0014884332,
-0.0071974015,
-0.033023372,
0.028710222,
0.0029024447,
0.016445532,
0.019078406,
0.029318826,
0.014619721,
-0.0024277999,
-0.0058776573,
0.024635224,
0.00985012,
0.023193097,
-0.0018076194,
0.021367285,
-0.009314284,
0.038659573,
-0.0016877179,
-0.020031003,
-0.01918425,
0.003916233,
-0.022544801,
-0.010061808,
-0.020110385,
0.0004738179,
-0.015281247,
-0.008513838,
0.0036946218,
0.0076670847,
0.0024327612,
0.040564764,
-0.015545857,
0.006284496,
-0.0038203117,
-0.008361687,
0.018377189,
-0.011470858,
-0.014183114,
-0.051810704,
-0.0040716915,
0.0058115046,
0.041014604,
-0.028075157,
0.021936197,
-0.007878773,
-0.0065457984,
-0.00129411,
-0.00001967781,
-0.0026692569,
0.0061720363,
-0.0063407253,
0.029239442,
-0.002738717,
-0.016736604,
0.019501783,
-0.021512821,
-0.0007528991,
-0.008467531,
-0.024291229,
0.0081963055,
0.0048787533,
-0.01741136,
-0.004131229,
-0.010551337,
0.023735547,
0.020242691,
0.02070576,
-0.0077861594,
-0.0068997145,
-0.0038600033,
-0.00019246268,
0.008507223,
-0.018231653,
-0.013627432,
0.032414768,
-0.004289995,
0.021698048,
-0.01686891,
-0.010233805,
-0.016948292,
-0.004934983,
0.0021780739,
-0.01895933,
0.008421225,
0.01741136,
0.003737621,
-0.008871062,
0.011424552,
-0.008765218,
-0.030774184,
0.009889811,
-0.023603242,
0.012820371,
0.031753242,
0.019223941,
0.0041444595,
0.0075281644,
-0.03686022,
-0.031118177,
-0.024423534,
0.032361846,
0.028498534,
0.013296669,
-0.0154135525,
0.0056494307,
0.009109211,
0.013852351,
-0.008533684,
0.00274864,
0.013501743,
0.010286727,
-0.022544801,
0.0040485384,
-0.64480245,
-0.022968177,
0.0054311273,
0.0044917604,
0.02148636,
0.0230211,
0.022081733,
-0.00014770632,
0.011715623,
0.04815908,
-0.0022524956,
0.03839496,
0.027519476,
-0.02532321,
-0.008844601,
-0.014752027,
-0.0084543,
-0.016815986,
0.012476377,
-0.046359733,
-0.018602107,
0.027281325,
-0.014910793,
0.018086117,
0.019012254,
0.00018398688,
0.024899833,
-0.017874429,
-0.0009699623,
-0.019316554,
0.0066880262,
0.00844107,
0.017067367,
0.02918652,
0.034690417,
-0.025508437,
-0.014619721,
0.016961522,
0.0027982544,
0.03331444,
-0.017980272,
-0.009757507,
0.028868988,
-0.0002995472,
-0.018178731,
0.0134885125,
-0.008130153,
-0.005368282,
0.02021623,
0.009155517,
0.018827025,
-0.01614123,
-0.020785142,
0.0139317345,
-0.0013263593,
-0.0045711435,
-0.004425608,
0.00082649384,
0.019303324,
0.0010989598,
-0.015162173,
0.006476338,
-0.011431167,
-0.013574511,
-0.010326419,
0.014778487,
-0.007190786,
-0.0019862314,
0.011781775,
-0.013799429,
0.008156613,
0.027678242,
-0.013839121,
-0.0030231732,
0.026196424,
0.0019481936,
-0.008917369,
-0.00024042331,
-0.017186442,
-0.0011460936,
-0.015784007,
0.009281208,
-0.041041065,
0.0046802955,
0.02511152,
0.010419033,
0.0056891222,
-0.011907466,
-0.007905234,
-0.007137864,
0.013786199,
0.016710144,
0.012694681,
-0.022981409,
-0.01304529,
0.020401457,
0.0017067367,
0.005212824,
0.008414608,
-0.008917369,
-0.01559878,
-0.008414608,
-0.008725526,
0.0076737,
0.01356128,
0.023854623,
-0.019872237,
0.018046426,
0.048000317,
-0.026183194,
0.008103692,
0.012754219,
0.0049647517,
0.009234901,
0.011967002,
-0.030615417,
-0.022663876,
0.01737167,
-0.012582222,
-0.018641798,
0.020282382,
0.0062514194,
0.015770776,
0.013892042,
-0.003301014,
-0.00028693685,
-0.01946209,
-0.022227269,
-0.0048225233,
-0.004667065,
-0.000459347,
-0.004624066,
0.019607626,
0.0033506285,
0.01536063,
-0.009453204,
0.016921831,
-0.009129057,
-0.02892191,
-0.0020821525,
-0.00081036915,
-0.011212863,
0.009453204,
-0.009506127,
0.0038699263,
-0.033049833,
-0.0039294637,
0.003889772,
0.00004597088,
0.007005559,
0.01689537,
-0.013680355,
-0.023087252,
0.017345209,
-0.0022872256,
-0.005702353,
-0.017199673,
-0.01315775,
-0.014368341,
0.010987944,
0.014090501,
0.035087332,
-0.023126943,
-0.014209575,
-0.0016025464,
-0.03095941,
0.012138999,
-0.007018789,
-0.02741363,
-0.047709245,
0.030774184,
-0.0062878034,
-0.0002011452,
0.021711279,
0.0012089385,
0.03532548,
-0.0024956062,
-0.011861159,
0.020308843,
-0.0066714883,
0.01611477,
0.02812808,
-0.032176618,
-0.0010551338,
0.018271344,
0.0021631895,
0.016551377,
0.012105923,
0.0055336636,
0.025521668,
-0.009433359,
0.013548049,
0.011212863,
-0.00985012,
-0.009347361,
0.024436764,
0.016194154,
0.0007748121,
-0.04125275,
0.020269152,
0.050064277,
0.016035387,
0.022663876,
0.0013619163,
0.022677107,
-0.0018952716,
0.0037343134,
-0.009982425,
0.017596588,
-0.00678064,
0.010161038,
0.0070254044,
-0.0031257097,
-0.025971506,
-0.012066231,
0.011060712,
-0.020917447,
0.016260305,
-0.022240499,
-0.0009468089,
-0.008844601,
-0.013250363,
0.041834895,
0.0077861594,
-0.020573454,
0.0046505267,
0.022055272,
-0.006439954,
0.0068930993,
0.006191882,
-0.003952617,
-0.009559048,
0.010094885,
-0.004309841,
-0.00313894,
0.014209575,
-0.008487376,
-0.012602068,
0.016736604,
0.025521668,
-0.0015363938,
0.003132325,
0.02250511,
0.0067508714,
0.008143383,
-0.015572319,
0.012000079,
0.01868149,
0.007263554,
0.02632873,
0.009955964,
-0.0008198786,
-0.018046426,
-0.014659413,
-0.01633969,
-0.0009294438,
0.015492936,
0.014606491,
0.03170032,
0.02021623,
0.03148863,
0.019223941,
0.02048084,
-0.0009071173,
0.007237093,
-0.0048721377,
-0.021909736,
0.014990176,
-0.01667045,
-0.009532588,
-0.016075078,
-0.024410304,
0.0026560263,
0.011325323,
0.016485224,
0.006565644,
0.015942773,
-0.012701296,
0.018125808,
0.011742084,
-0.023881083,
0.0011312092,
-0.0014578376,
0.022756489,
0.004309841,
-0.0101015,
0.009115826,
0.0054575885,
-0.029556975,
0.0037872356,
-0.016286766,
0.018694721,
0.008910753,
-0.018099347,
0.019250402,
-0.012866678,
0.037151292,
-0.009697969,
-0.017993502,
-0.0032348614,
0.006502799,
-0.015995694,
-0.021552512,
-0.0263155,
0.01636615,
0.010974714,
-0.018496264,
-0.022425726,
-0.014434494,
0.00869245,
0.016075078,
0.020269152,
0.013342977,
0.00805077,
-0.013078366,
0.009267977,
-0.026606569,
0.009281208,
0.022227269,
-0.0055270484,
-0.0026527187,
-0.032123696,
0.011874389,
0.0042106123,
0.037177753,
0.016220614,
0.0043131486,
0.038447883,
0.01684245,
0.0033853585,
-0.01948855,
0.0021896507,
-0.0035557013,
0.015479705,
0.00067392946,
0.006946021,
0.03402889,
-0.0005771813,
0.018853487,
0.019303324,
0.0019432321,
-0.025376132,
0.010233805,
-0.009446589,
0.012099308,
-0.027810548,
0.027969314,
0.00922167,
0.008388148,
-0.010399186,
0.026566878,
0.0154135525,
0.008745371,
0.0054311273,
-0.008963675,
0.025415823,
-0.0011179787,
0.006496184,
-0.015307709,
-0.0031224021,
0.0064631077,
0.021830354,
0.01432865,
-0.01636615,
0.025653973,
0.018469801,
-0.0052888994,
-0.023709087,
0.011060712,
-0.020454379,
0.027493015,
0.018178731,
-0.013852351,
-0.007237093,
0.012264689,
-0.0020424612,
-0.0018688105,
-0.039585706,
0.003605316,
-0.019859007,
0.012998983,
-0.017093828,
-0.020163309,
-0.012000079,
-0.016723374,
-0.02279618,
0.0037673898,
-0.019739931,
-0.032176618,
-0.0075612403,
-0.036966063,
0.0010948253,
-0.002131767,
-0.0026560263,
-0.0064267237,
-0.018999023,
-0.0009360591,
0.0019316555,
-0.0069790976,
0.011682547,
0.028683761,
-0.01944886,
0.009684739,
0.01686891,
-0.026209654,
-0.00037541593,
0.00025551437,
-0.013693585,
0.005940502,
0.030536033,
-0.006959252,
-0.015704624,
-0.011960387,
-0.0056527383,
0.020546993,
-0.0023765317,
0.011801621,
-0.012337457,
0.008361687,
-0.013256978,
-0.008646143,
0.02582597,
-0.021936197,
-0.029556975,
-0.0025716817,
-0.002060653,
-0.009036443,
-0.036542688,
0.020269152,
-0.0015248171,
-0.047391713,
-0.015440013,
0.0058842725,
-0.0032712454,
0.013025444,
-0.030112658,
0.006512722,
-0.008262458,
0.02841915,
0.020546993,
-0.009095981,
0.033182137,
0.017107058,
-0.009876581,
0.002488991,
0.027678242,
0.018840257,
-0.0053848205,
-0.029953891,
0.021195289,
0.0027701396,
-0.016419072,
-0.027175482,
0.00390631,
0.004815908,
0.03934756,
0.006380417,
-0.000100365876,
-0.008374917,
-0.0029917506,
0.0014735488,
0.0111202495,
0.0066351043,
-0.029556975,
-0.00079176377,
-0.0154135525,
-0.0053318986,
-0.0016488532,
0.035378404,
-0.028075157,
0.00447853,
0.01685568,
-0.02634196,
-0.010815947,
0.017755354,
-0.0037773126,
-0.036966063,
-0.018244883,
-0.017953811,
-0.016247075,
-0.032097235,
-0.0035656244,
0.011828083,
0.028524995,
0.021195289,
-0.008024309,
-0.012165461,
0.019276863,
-0.0059107337,
0.030932948,
-0.010022117,
-0.0106373355,
-0.0037343134,
0.019157788,
0.0068203313,
-0.005765198,
0.011947157,
-0.010207344,
0.023140173,
0.000048554964,
0.0037078524,
-0.022902025,
-0.02172451,
-0.022055272,
-0.013137903,
0.001141959,
0.017305516,
0.011252555,
-0.03140925,
0.0027684858,
-0.012939446,
-0.013223901,
-0.0022524956,
-0.027334249,
0.009162133,
-0.019038714,
-0.0009393667,
0.0031257097,
0.013759738,
-0.010505031,
-0.010180883,
-0.022571262,
-0.014963714,
0.008904138,
0.00672441,
0.004237073,
0.021526052,
0.0032547072,
-0.007892003,
0.014950484,
-0.001382589,
-0.0015471436,
0.0037574668,
-0.033182137,
-0.0033605513,
-0.00023174078,
-0.0038070814,
-0.004382609,
-0.009995656,
0.015281247,
-0.002675872,
0.020269152,
-0.025865661,
-0.011437782,
-0.012258074,
-0.039479863,
0.029345287,
-0.004934983,
0.02892191,
0.04358132,
0.004382609,
-0.008070615,
0.010855639,
0.02509829,
0.008282304,
0.0015405284,
0.022558032,
-0.02225373,
-0.006532568,
0.0018770796,
-0.0076141628,
-0.019528244,
-0.03662207,
0.036278076,
0.0065689515,
-0.0131180575,
-0.0093804365,
0.011126865,
-0.019607626,
0.056573693,
0.00897029,
-0.0064267237,
-0.0032844758,
-0.020083925,
-0.012231613,
0.022121424,
-0.036701456,
0.027731163,
0.004194074,
-0.0009261362,
-0.0074355504,
-0.01458003,
-0.02687118,
-0.0012163806,
-0.018906409,
0.0051863627,
-0.0047828318,
0.00020476292,
0.010022117,
0.0020656146,
0.0018225037,
-0.01536063,
-0.0480797,
0.033155676,
0.009248132,
-0.0037078524,
0.028736683,
0.0018125809,
0.007541395,
-0.013078366,
-0.002862753,
-0.027096098,
-0.0015496243,
0.0041179983,
-0.00092034787,
0.026011197,
-0.0069195605,
0.0071510943,
-0.014976946,
-0.0018059656,
0.009188594,
-0.03458457,
0.020838065,
-0.024013389,
-0.014513877,
0.0015082789,
0.005044135,
-0.0077067763,
0.02177743,
0.0013404167,
0.022637414,
0.0061621135,
-0.0041907663,
0.007137864,
-0.0013486858,
0.0049581365,
-0.019528244,
-0.003919541,
-0.03347321,
-0.008295534,
0.02228019,
0.0073098605,
-0.053266063,
-0.016061848,
-0.015810467,
0.009267977,
-0.015969234,
-0.02226696,
0.030615417,
-0.014130192,
0.0032398228,
0.0032695916,
-0.0027271404,
0.039797395,
-0.02562751,
0.01633969,
0.012231613,
-0.032652915,
-0.0009674816,
-0.003238169,
0.00626465,
-0.0044686073,
-0.025124751,
0.01943563,
-0.019051945,
0.047153562,
-0.04019431,
-0.0062580346,
0.0068534077,
0.0027536014,
-0.02456907,
0.019567935,
-0.005040827,
-0.008527068,
-0.025640743,
-0.01615446,
-0.0004262707,
0.015069559,
0.007541395,
-0.008156613,
-0.010094885,
-0.028498534,
-0.024913063,
0.002452607,
-0.03222954,
0.04704772,
-0.007746468,
0.010498416,
-0.021433437,
-0.03656915,
-0.0024774142,
0.0035523938,
-0.006145575,
0.007190786,
0.0064994916,
0.00742232,
0.015651701,
0.005851196,
-0.0101213455,
0.0055898936,
-0.025733355,
-0.024899833,
0.031144638,
-0.014460955,
0.0153474,
-0.013653894,
-0.051916547,
0.006519337,
0.009433359,
0.022730028,
-0.0025303364,
0.011847928,
0.011768545,
-0.00690633,
-0.0023219557,
-0.0079383105,
-0.0007057654,
0.011669316,
-0.000013140074,
-0.03683376,
-0.015744315,
-0.007839082,
0.0006363052,
-0.0230211,
0.010213959,
0.0012279573,
0.0053782053,
0.010339649,
-0.01459326,
-0.00078514847,
0.009876581,
0.010227189,
0.0066251815,
0.004068384,
0.010392571,
0.01099456,
-0.007733237,
0.002624604,
-0.01164947,
-0.003532548,
-0.008619682,
-0.0034465496,
-0.006324187,
-0.003638392,
-0.008877677,
-0.00421392,
-0.007852312,
-0.015651701,
0.0014016079,
0.008222766,
0.0043131486,
0.0052227466,
0.014513877,
-0.0027221788,
-0.003079403,
0.015770776,
-0.026659492,
-0.0025584511,
-0.010802717,
-0.037204213,
0.009691354,
-0.02918652,
0.0029818278,
-0.02611704,
-0.011867774,
0.007627393,
0.009691354,
-0.010048578,
-0.016286766,
0.024277998,
0.17898244,
-0.0022227268,
-0.004022077,
0.02560105,
-0.0037806202,
0.0011485743,
0.039770935,
0.0012436686,
-0.015175403,
0.028789606,
0.028075157,
0.008110307,
-0.016299997,
0.002684141,
0.014738796,
-0.0021615357,
-0.02918652,
-0.038289115,
-0.0013610894,
0.009512742,
0.0075943167,
-0.010829179,
0.01635292,
-0.0063043414,
0.03479626,
-0.0050474424,
-0.011054097,
0.03577532,
0.031832624,
0.012165461,
-0.01610154,
-0.016405841,
0.014209575,
0.0037243906,
0.006512722,
-0.003701237,
0.009929503,
-0.011609779,
0.00009318212,
0.0002710189,
0.005970271,
-0.0036417,
-0.021089444,
-0.017027676,
0.001578566,
0.024489688,
0.007991232,
-0.026249345,
-0.02403985,
0.017001214,
-0.005447665,
-0.0011146711,
-0.0066847187,
-0.0022541494,
-0.0013280131,
0.0025121444,
0.020533763,
0.0034928564,
0.0069790976,
-0.0024856834,
0.0024575687,
-0.0057883514,
-0.01845657,
-0.00048126007,
-0.030403728,
0.012443301,
-0.01917102,
-0.006701257,
-0.02561428,
-0.028763143,
0.0144874165,
0.0009848466,
-0.031938467,
0.039030027,
0.0016430648,
-0.015043098,
0.007402474,
0.039612167,
-0.0021433437,
0.02328571,
-0.02198912,
-0.018588876,
-0.022346344,
-0.010346265,
-0.009188594,
-0.02579951,
0.025362901,
0.024952754,
-0.007944926,
0.008864447,
-0.006959252,
-0.012046386,
-0.01614123,
-0.0049283677,
0.0053947433,
0.009717815,
0.03707191,
0.01615446,
0.0047398326,
-0.018721182,
-0.022597723,
0.087215565,
-0.010696873,
-0.009559048,
-0.0096384315,
0.0023087251,
-0.0209836,
0.00576189,
-0.016471993,
-0.013825891,
0.013759738,
-0.020031003,
0.0018390418,
-0.010716719,
0.010643951,
0.02582597,
0.0006867465,
-0.026805028,
-0.01229115,
-0.022571262,
0.0034300114,
-0.027545936,
0.0024360688,
0.033129215,
0.00562297,
-0.02303433,
-0.009294438,
0.031964928,
-0.0250586,
-0.024172155,
0.009764122,
-0.013223901,
0.010061808,
0.010505031,
-0.0030182118,
0.0071709403,
-0.008864447,
-0.020374997,
-0.022650646,
-0.00056271045,
0.0064300313,
-0.0070518656,
0.012105923,
0.0074289353,
0.011292246,
-0.017768584,
0.0286573,
-0.00077067764,
-0.019078406,
-0.0058379658,
-0.014685874,
0.008897522,
0.0077663134,
0.0057585826,
0.03921525,
-0.02741363,
-0.011722238,
-0.019859007,
0.002212804,
0.010591029,
-0.03220308,
0.011272401,
0.04350194,
-0.012707911,
-0.002184689,
0.030377267,
-0.16659868,
-0.011980233,
0.017464282,
0.014381572,
0.04268165,
-0.005933887,
0.026831489,
-0.0034597802,
-0.017199673,
-0.021049753,
0.022888795,
-0.005960348,
-0.034267038,
-0.038209733,
-0.008235997,
0.0153474,
-0.027201943,
0.023391554,
0.048952915,
0.0238017,
0.046174504,
0.027757624,
0.0027817162,
-0.0076406235,
0.005368282,
0.023246018,
-0.031091714,
0.0018605414,
-0.0030645186,
-0.0033043216,
-0.012602068,
0.010584414,
0.031091714,
0.0073230914,
0.0058412733,
-0.020083925,
-0.0032315538,
0.0071246335,
-0.0022524956,
-0.006158806,
0.014196345,
0.052075315,
-0.012787295,
-0.008394763,
-0.008116922,
0.002935521,
0.033975966,
-0.021049753,
0.0238017,
-0.005629585,
0.013243748,
-0.01563847,
-0.017212903,
-0.003114133,
0.0016008925,
0.008725526,
-0.0023666087,
0.015254786,
0.00055444136,
0.022584492,
0.0076737,
-0.03603993,
0.019541474,
0.0097508915,
-0.035113793,
-0.0025187596,
0.0017067367,
-0.030747721,
-0.00383685,
0.022584492,
-0.038289115,
-0.018337497,
-0.0048291385,
0.011437782,
0.016233845,
0.03603993,
-0.01483141,
0.02022946,
-0.005278976,
-0.018535955,
-0.0012874947,
0.0067211026,
-0.023762008,
-0.0012742642,
-0.026924102,
0.01635292,
-0.0011518819,
0.018125808,
0.017993502,
-0.033049833,
0.016233845,
-0.037283596,
0.0041179983,
-0.013250363,
-0.00060984417,
0.014725566,
0.01943563,
0.0026179885,
0.021698048,
-0.037257135,
0.010835794,
0.013759738,
-0.029398208,
0.019382708,
-0.01432865,
-0.00013592289,
-0.0035193176,
0.0101941135,
0.047259405,
-0.008321995,
-0.017477512,
0.009525972,
-0.010372725,
0.009777352,
-0.014011118,
0.029477593,
0.0026262577,
0.015135711,
-0.01891964,
-0.0123771485,
0.064512,
0.0057155835,
-0.023365093,
0.019382708,
-0.00715771,
-0.025190905,
-0.12320258,
-0.032996908,
0.024211846,
0.027334249,
-0.000637959,
0.015532627,
-0.0153474,
0.002712256,
0.0078258505,
0.038262654,
-0.015215094,
-0.01715998,
-0.033949506,
-0.023470936,
0.026222885,
0.026831489,
0.0119339265,
-0.032573532,
-0.016815986,
0.042866874,
0.0035027794,
0.012251459,
0.018774103,
-0.005130133,
-0.017742123,
-0.025548128,
-0.0008699065,
0.018840257,
-0.010154421,
0.021698048,
0.021287901,
-0.010776256,
-0.015426783,
0.009387052,
-0.015162173,
-0.0012593798,
-0.016538147,
-0.0058743497,
0.026487496,
-0.040406,
0.018602107,
0.011583318,
0.020586684,
0.009135672,
0.005573355,
0.01995162,
-0.04453392,
-0.01685568,
-0.031594474,
0.001525644,
-0.0076737,
0.0059371945,
-0.004594297,
0.0054112813,
-0.0020093848,
-0.027837008,
0.013395899,
0.0029156753,
-0.005871042,
0.0021449975,
0.008586606,
0.0058412733,
-0.016247075,
0.027704703,
0.01432865,
-0.020454379,
-0.0119339265,
-0.0011990156,
0.013237133,
-0.015757546,
-0.012000079,
0.007270169,
-0.0007504184,
0.011232709,
-0.023867853,
-0.0061521903,
0.011087174,
0.0016546416,
0.002935521,
0.007164325,
-0.023378324,
-0.011331938,
0.008540299,
-0.004362763,
0.008732141,
0.044189926,
0.009916273,
0.0010195767,
-0.005156594,
-0.008321995,
-0.008778448,
0.0081235375,
-0.0045016836,
-0.026553648,
0.01684245,
0.015215094,
-0.0014512223,
-0.029318826,
-0.0013387629,
-0.005593201,
0.0045116064,
0.0071974015,
-0.0455659,
0.017874429,
0.012641759,
-0.014897563,
0.00023236095,
-0.013290054,
0.011973618,
0.013084982,
-0.00077315833,
0.035299018,
-0.02968928,
-0.0028429073,
-0.02863084,
0.009572279,
-0.013541434,
-0.0105645675,
0.009592125,
0.019792853,
0.011662701,
0.0078258505,
-0.0250586,
0.0061422675,
0.010650566,
0.01304529,
0.008467531,
-0.019144557,
0.003995616,
0.00237157,
-0.01008827,
-0.012979137,
0.0014140115,
-0.021843584,
0.007726622,
-0.005682507,
-0.0066946414,
-0.01946209,
0.018734412,
0.02942467,
0.029001294,
0.028233923,
-0.027029946,
-0.034452267,
0.017503975,
-0.0076406235,
-0.009353976,
-0.017609818,
-0.021592204,
0.020163309,
-0.019329786,
-0.006307649,
0.017040906,
0.01664399,
0.0061621135,
-0.032097235,
-0.046968337,
0.009731045,
-0.0026990254,
0.006658258,
0.0040915376,
-0.032361846,
0.029583436,
-0.021539282,
-0.015757546,
0.009572279,
0.00715771,
-0.024899833,
-0.01304529,
-0.009479665,
0.024449995,
-0.0143021885,
-0.01509602,
-0.0013098211,
-0.01561201,
0.004567836,
0.008871062,
-0.004415685,
-0.012145614,
0.04064415,
-0.0074289353,
0.013065136,
0.029530514,
-0.0032348614,
-0.0071841707,
0.020917447,
0.04069707,
0.00074793765,
-0.020269152,
0.033843663,
0.002426146,
-0.0018704643,
-0.0145668,
0.013918504,
-0.009003367,
-0.0076141628,
0.0074487813,
0.028948372,
0.014804948,
0.0012990714,
0.005699045,
0.024476457,
0.0077133914,
0.011021021,
0.0052095163,
-0.041146908,
-0.02561428,
-0.024661684,
-0.012727757,
-0.05252515,
-0.015956003,
0.0006995636,
-0.00908275,
0.010736564,
0.009420129,
0.008745371,
-0.017742123,
-0.012873293,
-0.009228285,
-0.0042337654,
-0.001936617,
0.020785142,
-0.010544722,
0.023219557,
0.0070518656,
-0.00562297,
0.01305852,
0.038553726,
0.021115905,
-0.009400282,
0.010339649,
0.031541552,
-0.011424552,
-0.018535955,
-0.013151134,
0.0033407055,
-0.00019101558,
-0.020785142,
0.0217642,
-0.006807101,
0.007931695,
0.06964544,
-0.014646183,
-0.0021416899,
-0.010213959,
-0.0076737,
0.01139809,
0.012535915,
-0.005682507,
-0.0051367483,
-0.030377267,
0.022187578,
-0.004448761,
0.0067674094,
-0.029874507,
-0.027016716,
-0.00017923216,
0.0015024906,
0.019131327,
-0.013971426,
-0.024833681,
0.022677107,
-0.02352386,
0.037971582,
0.0038864643,
-0.0040783067,
-0.014897563,
0.016419072,
-0.008864447,
-0.013342977,
-0.020943908,
-0.014130192,
0.0033307828,
-0.02579951,
-0.025918582,
0.013600972,
-0.0058214273,
-0.00817646,
-0.031964928,
0.0018225037,
-0.018906409,
-0.00010269155,
0.025481977,
-0.035272557,
-0.021922966,
-0.04022077,
-0.013653894,
-0.02403985,
-0.008460916,
-0.023867853
] |
This article describes a R package Boruta, implementing a novel feature selection algorithm for finding emph{all relevant variables}. The algorithm is designed as a wrapper around a Random Forest classification algorithm. It iteratively removes the features which are proved by a statistical test to be less relevant than random probes. The Boruta package provides a convenient interface to the algorithm. The short description of the algorithm and examples of its application are presented. | [
-0.0384341,
0.0008906097,
-0.0019147674,
0.0027472752,
-0.009261647,
0.016178397,
-0.029193267,
0.0109682875,
-0.027667003,
-0.02178395,
-0.009719526,
0.011384541,
-0.0062715574,
-0.008699705,
-0.01315362,
0.000009803373,
0.023892969,
0.002596383,
0.0018870173,
-0.0028062444,
-0.004224976,
0.0136669995,
-0.0164004,
-0.013229934,
-0.0069028754,
0.012036673,
0.027667003,
-0.032134794,
-0.009421211,
0.005515363,
0.02016056,
-0.015956396,
-0.026862245,
-0.019341927,
-0.034438066,
-0.011440042,
0.008019824,
-0.00046525034,
0.0140555035,
0.0037775033,
0.034771066,
-0.0025651641,
0.0041868193,
-0.022005951,
0.030358776,
0.0040307245,
0.015068388,
-0.004672449,
-0.011412292,
0.0034132812,
0.008845394,
0.01121804,
-0.032467797,
0.008692767,
0.008665017,
0.0081863245,
-0.00013701688,
-0.009997029,
-0.009344898,
0.002240833,
0.004880576,
0.0027524782,
-0.0272785,
0.012577802,
0.0053349864,
-0.006351339,
-0.008373639,
0.028180383,
-0.0003208623,
0.025530234,
0.00023349236,
0.030775031,
0.011419229,
0.026501492,
0.025211105,
-0.02095144,
-0.025044603,
-0.001641601,
0.0326343,
0.0013120667,
0.008644204,
0.008734392,
0.0027281968,
0.011329041,
0.028277509,
0.026556993,
0.015415266,
0.028346883,
-0.031330038,
0.007052033,
-0.007735383,
0.010836474,
0.023046585,
0.0058032717,
-0.029304268,
0.025433106,
-0.008193262,
0.027167497,
0.00068768597,
-0.02018831,
-0.002462835,
0.003954411,
-0.019008923,
0.0036838462,
-0.018523294,
0.0060183364,
-0.0074231927,
-0.0037081277,
0.009344898,
0.009775027,
-0.019328052,
0.032523297,
-0.016192272,
-0.036352832,
0.010406345,
0.011412292,
0.03724084,
-0.008158575,
-0.021145694,
0.010170468,
0.012355801,
0.00061831035,
0.022588706,
-0.007270566,
0.011759169,
-0.005112984,
-0.0025131323,
-0.027778003,
-0.015429141,
-0.015651142,
-0.007215066,
0.012737366,
0.0065698726,
-0.008477703,
-0.006080774,
0.0008142965,
-0.025238855,
-0.0066774045,
-0.0382121,
-0.019674929,
-0.0017413284,
-0.004918732,
-0.02195045,
-0.04623192,
-0.018259667,
0.031108035,
0.032107044,
0.029387519,
0.011641231,
-0.012494552,
-0.012952431,
-0.048562944,
0.0014672946,
0.015789894,
0.00096605567,
-0.024267597,
0.028888013,
0.010996038,
-0.020854315,
0.0062195254,
-0.0022737863,
0.013049557,
0.016095147,
-0.0020084246,
0.032190293,
0.019536179,
-0.00022590441,
-0.011551043,
0.008519328,
0.0055014878,
-0.00007989038,
0.039627362,
-0.036963336,
0.0030369184,
0.026154613,
-0.009566899,
0.0067502493,
0.013465811,
-0.0061223996,
0.00080519094,
-0.0065039657,
0.0022980678,
0.040959373,
-0.008463827,
0.0045579793,
0.022158578,
-0.003382062,
-0.0033230928,
0.010489596,
0.0067294366,
0.008699705,
0.015359765,
-0.020049559,
0.018884048,
-0.6415859,
-0.00078437827,
0.005733896,
0.000091434915,
0.008914769,
0.011696732,
0.015470766,
-0.021312194,
0.013771064,
0.018786922,
-0.02414272,
-0.0065906853,
0.01910605,
-0.030997032,
-0.02533598,
-0.03732409,
0.00711794,
-0.02072944,
0.032301296,
-0.0040584747,
-0.03374431,
0.020590687,
-0.021395445,
-0.005036671,
0.0055223005,
0.0149990115,
-0.0033664526,
-0.015900895,
-0.0025061949,
0.005196235,
-0.003982161,
0.024614474,
-0.00044075208,
0.0124529265,
0.04143113,
-0.015498516,
0.0007787415,
0.017663036,
0.01961943,
0.0164559,
-0.035575826,
-0.03266205,
0.03640833,
0.006021805,
0.01756591,
0.010038654,
0.0009461102,
0.016608527,
-0.00024389871,
-0.013590687,
-0.02568286,
0.011745295,
0.00020216493,
0.0045996043,
0.0129593685,
-0.015970271,
0.016122898,
-0.033355806,
-0.00013549929,
-0.024697725,
-0.013458873,
-0.0061536185,
-0.0023986625,
-0.012411301,
0.00038720274,
0.0002272052,
-0.0062334007,
0.006653123,
0.029387519,
-0.035520323,
0.0035208133,
0.0084222015,
-0.0048389505,
-0.003522548,
0.0052517354,
0.006514372,
0.024614474,
0.005116453,
-0.0047834497,
0.005144203,
0.030025775,
-0.0008732658,
-0.015193264,
-0.002422944,
0.0135490615,
0.004034193,
-0.0016190539,
-0.011960359,
0.008671954,
-0.0023778498,
0.014832511,
0.036352832,
-0.025516357,
-0.007721508,
-0.003638752,
-0.009747276,
-0.010316157,
0.009490587,
0.016927654,
-0.03396631,
-0.01810704,
-0.013764125,
0.0010389001,
0.0068369685,
0.020327061,
0.0005472003,
0.014971262,
-0.0070034703,
0.012078297,
-0.021339945,
-0.005674927,
0.00842914,
-0.008026761,
-0.013375622,
0.02414272,
-0.028638262,
0.0023102085,
-0.003944005,
-0.01642815,
-0.021992076,
0.014582758,
-0.004245789,
0.0019112987,
-0.032467797,
0.004675918,
0.002337959,
0.025238855,
0.010669973,
-0.02092369,
-0.014707634,
0.018287417,
-0.009476712,
0.01363925,
-0.008866206,
0.017593661,
-0.014305255,
0.012036673,
0.006961845,
-0.0024298816,
-0.03746284,
-0.023781966,
-0.00047869186,
0.023754217,
-0.006118931,
-0.02573836,
-0.026598617,
-0.007045096,
0.007978198,
0.009143708,
0.009442024,
0.006465809,
0.006979189,
-0.029221017,
0.0046169483,
-0.0045232913,
-0.002254708,
-0.027014872,
-0.027375625,
-0.025988113,
-0.003846879,
0.015789894,
0.029276518,
-0.012577802,
0.0001890486,
-0.011516355,
-0.024170471,
-0.01281368,
0.031163534,
-0.024808727,
-0.033217054,
0.024919728,
-0.012931618,
0.016220024,
0.024586724,
-0.023712592,
0.025127854,
-0.03180179,
0.00083944516,
-0.02343509,
-0.018453918,
-0.0063027763,
0.0090465825,
-0.01258474,
-0.01810704,
0.018870173,
-0.00068811956,
0.014319131,
0.01403469,
-0.022255704,
-0.0018662045,
-0.01648365,
0.02235283,
-0.009483649,
0.012466801,
0.0036456895,
0.013715562,
0.015873145,
0.019980183,
0.006812687,
0.02784738,
0.011974234,
0.0070485645,
0.000114469796,
-0.028097132,
0.018578794,
-0.016830528,
0.026473742,
-0.035437074,
0.021867199,
-0.014666009,
0.013216058,
-0.019536179,
-0.02403172,
-0.007825571,
0.004055006,
0.010336969,
-0.0061605563,
0.031330038,
-0.016719528,
-0.0012643709,
-0.0009669229,
-0.0030109026,
0.020993067,
0.014222004,
0.012987118,
-0.011412292,
0.008741329,
0.009941529,
0.051226966,
-0.02641824,
0.0044261655,
0.0008485507,
0.015332015,
0.008935582,
0.01821804,
-0.039044607,
0.014693759,
-0.01796829,
0.013500499,
-0.028013881,
-0.021853324,
0.013618437,
0.019674929,
0.0020465811,
0.02784738,
-0.017746286,
0.02178395,
0.016164523,
-0.0011577059,
0.019633304,
-0.020535188,
0.0046620425,
0.0120991105,
0.018287417,
0.018259667,
-0.03488207,
0.002223489,
0.026112989,
0.028444009,
0.028721511,
0.035881076,
0.017385533,
0.017038656,
0.0033404368,
0.021881076,
-0.013986127,
-0.00024194752,
-0.004308227,
-0.0045579793,
-0.0024246783,
-0.0007778743,
-0.020021807,
0.008373639,
-0.009185334,
0.033300303,
0.016192272,
-0.023074336,
0.031912792,
0.006372152,
0.0027368688,
-0.03402181,
-0.02622399,
0.027472751,
0.029665021,
-0.0124529265,
-0.016650151,
-0.00871358,
-0.024184346,
-0.012106048,
0.0010640487,
0.013618437,
0.02958177,
0.0029918242,
0.02038256,
-0.0065421225,
0.024891978,
0.02414272,
-0.016580777,
0.0028149164,
-0.013091182,
-0.0029658084,
0.011946484,
-0.021867199,
-0.026182365,
0.035548076,
0.021159569,
-0.008609517,
0.002294599,
0.011377604,
0.01258474,
0.0045024785,
-0.014346881,
0.013250746,
-0.008956394,
0.0016650152,
0.035603575,
0.030941533,
0.013118932,
0.011925671,
0.020049559,
-0.005768584,
-0.0007557608,
0.004415759,
0.0010675176,
0.044650156,
0.01810704,
-0.0007540264,
0.016691778,
-0.002960605,
0.0043776026,
-0.021090193,
-0.014707634,
0.0065802787,
-0.004159069,
-0.01144698,
-0.00421457,
0.019314175,
0.005303767,
-0.008151636,
0.00076790154,
0.0045683854,
-0.015470766,
0.0069826576,
0.0140555035,
-0.00899802,
0.008720517,
-0.0014655603,
0.0053766114,
0.0064415275,
0.008755205,
0.02684837,
0.02468385,
0.026889995,
0.00054676674,
0.008075324,
0.008498515,
-0.009511399,
0.018467793,
-0.022796834,
0.015970271,
0.018800797,
0.003359515,
-0.017926663,
-0.004433103,
0.01227255,
0.02024381,
-0.0002692642,
0.015595643,
-0.0037115964,
-0.008345889,
0.021104068,
0.012112985,
0.0045822607,
-0.0163449,
0.004991577,
0.0016884295,
-0.018301291,
0.0046516364,
0.0040445994,
0.012223987,
0.005321111,
0.031080283,
-0.020451937,
-0.04140338,
-0.0115926685,
-0.008900894,
0.021700699,
-0.00127391,
0.00092356314,
0.010149655,
-0.017829537,
-0.008533203,
-0.028444009,
-0.02841626,
-0.010815661,
-0.031663038,
-0.04847969,
0.025599608,
0.0124529265,
0.02516948,
0.00449901,
-0.011315166,
0.0030056993,
0.014846385,
-0.0030230433,
-0.014090192,
0.0052517354,
-0.034354813,
0.01819029,
-0.015817644,
-0.027583752,
0.002781963,
-0.013084245,
0.02038256,
-0.020660063,
0.0031635289,
0.018911798,
-0.014929636,
0.015332015,
0.005414768,
0.01602577,
0.0012409566,
0.0006053024,
-0.041542128,
0.02511398,
-0.016955405,
-0.021104068,
-0.02793063,
-0.005525769,
0.008179387,
0.016941529,
-0.034660067,
0.016178397,
-0.02836076,
0.01064916,
-0.009344898,
-0.008651141,
-0.0064900904,
0.016636277,
0.021048566,
0.0006174431,
0.014485632,
0.023768092,
-0.014173442,
0.003532954,
-0.03069178,
0.011308229,
0.025238855,
-0.02081269,
0.030081274,
-0.021728449,
-0.004863232,
-0.019119924,
-0.01349356,
-0.020021807,
0.019452928,
0.00070589705,
-0.00081993325,
-0.04709218,
0.0004205898,
-0.016289398,
0.01529039,
-0.019466802,
-0.0070971274,
-0.020771064,
-0.005876116,
-0.0021315664,
-0.010010904,
-0.0040931622,
-0.014388506,
-0.009657088,
0.016775029,
-0.009462836,
0.013070369,
0.007672945,
0.014707634,
-0.0138196265,
-0.023754217,
-0.02095144,
-0.022963334,
-0.00925471,
-0.009469774,
0.022325078,
0.019980183,
0.027472751,
-0.019910807,
-0.0035624388,
0.023892969,
-0.0054390496,
0.009171459,
-0.010343907,
-0.00092182873,
-0.020451937,
-0.007818634,
0.023240836,
0.014582758,
0.006333995,
-0.03532607,
0.0037115964,
0.010094155,
-0.008588703,
0.0044747284,
-0.03071953,
-0.015318139,
-0.009955403,
0.0076382575,
-0.0008476835,
0.021714574,
-0.021908825,
0.008137762,
0.01426363,
-0.004956889,
0.027902879,
0.004655105,
0.021770073,
-0.011884046,
-0.009830527,
0.016095147,
0.02314371,
-0.0050470773,
0.0044920724,
-0.02619624,
0.003447969,
0.029082265,
0.012258674,
0.011134789,
0.010170468,
-0.00034861255,
-0.0075064437,
0.0010909318,
-0.025002979,
-0.0032398421,
0.018426169,
-0.0050297333,
-0.021520322,
-0.006306245,
0.00910902,
0.0028565417,
0.0005697474,
0.007825571,
-0.009587713,
0.021076318,
-0.00882458,
-0.029859273,
-0.016261648,
-0.004814669,
0.044428155,
0.02622399,
0.012536177,
0.013958378,
-0.021742323,
-0.035437074,
-0.0012973243,
0.005761646,
0.013930627,
-0.0013346138,
0.018897923,
-0.03424381,
-0.017718537,
0.014360756,
-0.0036803773,
-0.035770077,
-0.024517348,
0.014222004,
0.02616849,
0.010718536,
-0.0061258683,
-0.017205156,
-0.020354811,
0.030469779,
-0.017912788,
-0.00024411551,
0.0045406353,
-0.013951439,
0.008505452,
0.016650151,
-0.032107044,
0.028291384,
-0.006566404,
-0.014888011,
-0.00025387146,
0.0095183365,
0.0102606565,
-0.015831519,
0.013757188,
0.025530234,
0.012785929,
-0.015554017,
-0.00421457,
0.013465811,
0.003635283,
-0.004561448,
-0.008276513,
0.042013884,
0.00435679,
-0.0075272564,
-0.008449952,
0.003021309,
0.01349356,
0.01281368,
-0.016386524,
-0.0008212341,
-0.0014811697,
-0.002880823,
0.020368686,
-0.0013762391,
-0.011682857,
0.0024819132,
0.0047903876,
0.013542124,
-0.04076512,
-0.024045594,
-0.0021107537,
-0.024017844,
-0.0033525776,
-0.005050546,
-0.014888011,
0.039821614,
0.023781966,
0.002445491,
0.0016962342,
0.026598617,
-0.030053524,
-0.014062441,
0.0024350847,
-0.010829536,
-0.030941533,
0.00575124,
0.00094090705,
-0.006802281,
0.011058476,
-0.0328008,
-0.01864817,
-0.018412294,
-0.008470764,
0.008644204,
0.0033144208,
-0.03593658,
-0.014249755,
-0.0056645204,
0.0037289404,
-0.00882458,
-0.010600597,
0.013528248,
0.00081212854,
-0.012737366,
0.0329118,
-0.02257483,
0.012987118,
-0.0012609022,
0.017288407,
0.0013944502,
-0.055361755,
-0.0129593685,
-0.008935582,
0.013660062,
-0.0041729445,
-0.022408329,
0.009303273,
-0.009011894,
-0.01369475,
-0.006736374,
-0.0008906097,
-0.014555008,
0.021672947,
0.027750254,
-0.016677903,
0.007957385,
-0.0090465825,
-0.025044603,
-0.0013953174,
0.005674927,
-0.005595145,
-0.007936573,
0.0018453918,
0.032523297,
0.022644207,
-0.04473341,
-0.017801788,
0.018967299,
-0.040987123,
0.0039127856,
-0.0052482667,
0.015262639,
-0.0020309717,
-0.018814672,
0.026473742,
-0.00012064856,
0.0009721261,
0.025849361,
-0.005716552,
-0.0030993563,
-0.0049985144,
0.014832511,
0.018967299,
0.0054112994,
-0.04933995,
-0.0046134796,
0.00016541753,
0.008942519,
0.003992568,
0.021423196,
-0.033161554,
-0.011280478,
-0.012889992,
0.018134791,
0.00017278868,
-0.0056922706,
0.017038656,
-0.023324087,
-0.01631715,
0.0014924433,
-0.014048566,
-0.025460858,
0.01198811,
0.01807929,
-0.008776017,
0.022560956,
-0.028915765,
-0.02576611,
0.014721509,
-0.01702478,
0.01423588,
0.02852726,
0.0077770087,
0.028000006,
-0.018259667,
0.00057885295,
-0.014131816,
-0.0019650648,
-0.010177406,
-0.019744305,
0.029942524,
0.017468784,
-0.00799901,
-0.035353824,
0.011231915,
-0.000091705915,
-0.0001507836,
-0.019938556,
-0.0012860508,
-0.024836477,
0.013778001,
-0.014638259,
-0.013000994,
0.00078958145,
0.007464818,
0.0010189546,
-0.0076868203,
-0.0014308725,
0.012695741,
-0.029248767,
0.015151639,
-0.011329041,
-0.0057373648,
0.0041382564,
0.031135784,
-0.0047071367,
-0.023781966,
0.016331024,
0.1865927,
-0.030775031,
0.00882458,
0.017982164,
0.018911798,
0.0009044848,
-0.007069377,
-0.005511894,
-0.0018349855,
-0.0040133805,
0.01751041,
0.0015895691,
-0.026973246,
0.0063270577,
0.0015045841,
0.012973243,
-0.02963727,
-0.031302284,
-0.019425178,
0.008845394,
0.0056610517,
-0.0019425177,
-0.013417248,
-0.0061536185,
0.019744305,
0.0048112003,
-0.0046793865,
-0.016178397,
0.007610507,
0.0030369184,
-0.011578794,
-0.017149657,
0.0012704413,
0.014222004,
0.0049013887,
0.00521011,
0.007111002,
0.007072846,
0.01067691,
-0.014069378,
0.006566404,
0.015040637,
-0.0029311206,
0.013743313,
-0.0032450452,
0.02041031,
-0.004495541,
0.0026865713,
0.0273895,
0.0034150155,
-0.012140736,
0.010017841,
0.019938556,
0.013833501,
-0.028832514,
-0.014985137,
-0.006372152,
-0.0015444751,
0.030913781,
0.013111995,
-0.029137766,
0.02084044,
0.00076486636,
0.02565511,
-0.034604564,
0.014971262,
-0.02963727,
0.014444007,
0.021395445,
0.0032120917,
0.004703668,
-0.00055673945,
-0.006212588,
0.013375622,
-0.02092369,
-0.032190293,
0.000756628,
0.025960362,
0.025641235,
0.007353817,
0.014555008,
-0.012744304,
-0.014333006,
-0.025349857,
-0.0030525278,
-0.038045596,
0.0015956396,
-0.019855306,
-0.010177406,
-0.022214077,
0.011509418,
-0.036075328,
-0.013354809,
-0.017912788,
-0.0046342923,
0.02568286,
-0.006736374,
0.032995053,
-0.033300303,
0.020993067,
-0.04392865,
0.06510209,
0.021575822,
0.014013878,
0.005144203,
0.024933603,
-0.020396436,
0.013882064,
0.018384542,
-0.006961845,
0.0076660076,
-0.035353824,
0.00959465,
-0.012633303,
-0.0010805255,
-0.00080519094,
0.03479882,
-0.00876908,
0.010954413,
0.006847375,
0.011169477,
-0.020132808,
-0.0054390496,
0.0063756206,
0.004051537,
-0.004179882,
-0.017746286,
0.0013059963,
-0.024281472,
-0.005782459,
0.017413285,
-0.028027756,
-0.007645195,
-0.005310705,
0.005255204,
-0.019772055,
-0.021548072,
-0.038989104,
-0.012244799,
0.02129832,
0.00018146064,
0.027264625,
0.008852331,
-0.0010128842,
-0.02579386,
-0.00066643965,
0.0026831026,
0.0054772063,
0.0005511027,
-0.0024281472,
0.010323094,
-0.018495545,
-0.020965317,
-0.023518339,
-0.004738356,
-0.028749263,
-0.0033699214,
-0.028291384,
0.016442025,
-0.010281469,
-0.042263635,
-0.0032519829,
0.019938556,
-0.008984145,
-0.011613481,
-0.0073191295,
-0.17815663,
-0.004086225,
0.03157979,
-0.025918737,
-0.001779485,
0.015262639,
0.010919725,
0.0015141232,
-0.010891975,
0.0029571364,
0.02849951,
0.017829537,
-0.016705653,
-0.027916756,
-0.018606545,
-0.008110012,
-0.0060460865,
0.021312194,
0.05694352,
0.008762143,
0.023865217,
-0.030997032,
0.016719528,
-0.00449901,
0.018995048,
0.00506789,
0.025433106,
0.027084248,
0.012265612,
-0.042180385,
0.00041842178,
0.007541131,
0.007853322,
-0.037435092,
-0.0004912662,
0.01019128,
0.011370666,
-0.020715564,
0.012654115,
0.0056610517,
0.024642225,
0.019910807,
-0.0048181377,
0.009393461,
0.0041278503,
0.03527057,
0.00047825827,
-0.021159569,
0.008005948,
-0.00845689,
0.014790885,
-0.000019660945,
0.018884048,
-0.0027455406,
0.035881076,
0.013444997,
0.0005255204,
0.020118933,
-0.005817147,
-0.020826565,
0.00015100041,
-0.015054513,
0.021423196,
0.021978201,
0.008449952,
-0.029970273,
-0.0070971274,
-0.004988108,
-0.008241825,
-0.012799804,
-0.005577801,
0.013105057,
-0.015123888,
0.0009027504,
0.005498019,
0.008817643,
-0.020771064,
0.012563927,
0.02235283,
0.0056922706,
-0.033050552,
0.02861051,
0.010558971,
-0.003812191,
0.036519334,
0.024406347,
0.0077145705,
-0.0051546097,
-0.034327064,
-0.02573836,
0.013222996,
-0.025668984,
-0.0018072353,
0.0057373648,
-0.0054217055,
0.010545096,
-0.02149257,
-0.020354811,
0.0023154118,
-0.041264627,
0.01580377,
-0.006868188,
-0.018856296,
0.0073676924,
0.052891985,
-0.0013953174,
0.0013684344,
0.0048216064,
0.030913781,
0.017274532,
-0.016664026,
0.0111209145,
0.002539148,
0.013451936,
-0.022547081,
0.031274535,
-0.001890486,
-0.01534589,
0.04498316,
-0.0219227,
0.047785938,
-0.012258674,
0.0012028001,
-0.001721383,
0.001850595,
-0.03749059,
-0.10822599,
-0.0040133805,
-0.0009868684,
0.0092824595,
-0.024045594,
-0.0019442522,
-0.009927653,
0.029859273,
-0.014319131,
0.009074333,
-0.010787911,
-0.026432116,
-0.0037636282,
-0.0009903371,
-0.00030915518,
0.0010276266,
-0.010982162,
0.01101685,
-0.0063097137,
0.028235883,
0.009095145,
-0.038905855,
0.011738357,
-0.01124579,
0.009948466,
0.0020864722,
-0.02135382,
0.0027125874,
-0.0042770077,
0.016705653,
0.000568013,
-0.009483649,
0.019341927,
-0.012938555,
-0.017635286,
-0.0050123897,
-0.033439055,
-0.022755207,
-0.007735383,
-0.021020817,
-0.0059628356,
-0.024933603,
-0.0002465003,
-0.0063201203,
0.00845689,
-0.02852726,
-0.02070169,
0.015609518,
-0.0065039657,
-0.0075203185,
-0.022325078,
-0.039849363,
-0.013216058,
-0.010871162,
0.0060564927,
0.008089199,
0.018884048,
0.022907835,
-0.019411303,
-0.0065837475,
0.011134789,
0.0041868193,
-0.025960362,
0.036880087,
0.014499508,
-0.010690785,
-0.0050540147,
-0.02741725,
0.011100101,
-0.038739353,
-0.024489598,
0.009136771,
0.011266603,
0.0123349875,
-0.014333006,
0.020687815,
-0.042263635,
-0.03599208,
0.022852333,
-0.014006941,
-0.008443015,
-0.0135490615,
-0.00435679,
-0.02311596,
0.004450447,
0.012987118,
-0.006868188,
-0.016414275,
-0.008838456,
-0.025904862,
0.013320122,
0.00933796,
-0.002924183,
-0.01805154,
-0.007610507,
0.025419232,
0.0064415275,
0.0004739223,
0.004339446,
-0.001561819,
-0.025849361,
-0.025668984,
-0.05805353,
0.01529039,
0.0038676916,
-0.023046585,
-0.012487614,
0.008720517,
0.016830528,
0.015706643,
-0.0028877608,
0.031413287,
-0.023754217,
-0.02070169,
-0.011037664,
-0.005640239,
-0.013146683,
-0.01338256,
0.0025408827,
-0.025349857,
0.04814669,
0.0042215073,
-0.01648365,
0.007735383,
0.012106048,
0.015567892,
-0.020007933,
-0.034715567,
-0.0023136775,
0.022685831,
-0.0019112987,
0.0044920724,
-0.0068820626,
-0.03155204,
-0.024905853,
-0.0006438926,
0.008762143,
-0.014104066,
-0.008637266,
0.011870171,
0.020757189,
0.030969283,
-0.017940538,
-0.0076174447,
0.026376616,
-0.016261648,
-0.01426363,
0.02038256,
-0.035492573,
-0.002024034,
-0.0042770077,
0.001020689,
0.020909816,
0.009830527,
-0.00067814684,
-0.055139754,
-0.0010779239,
-0.015554017,
-0.01130129,
0.01008028,
-0.028693762,
-0.026778994,
0.027514376,
0.013375622,
0.009705652,
0.016733402,
-0.017343909,
-0.015692769,
0.0008923441,
-0.00042470897,
0.03293955,
-0.013833501,
-0.03196829,
-0.022103077,
-0.0008129957,
0.0032450452,
0.044400405,
0.0048701693,
-0.01753816,
-0.006202182,
-0.014721509,
0.0330783,
0.022325078,
-0.00068334996,
-0.014104066,
0.0074995058,
0.03205154,
-0.008012885,
0.027056497,
-0.007867197,
0.0034635784,
0.019994058,
-0.01474926,
0.01642815,
-0.008505452,
0.012168486,
-0.04254114,
0.0056159575,
-0.012425176,
0.016525276,
0.018606545,
0.018467793,
-0.012418238,
0.013708625,
0.0092824595,
-0.02633499,
-0.0028374635,
0.0065698726,
-0.001309465,
-0.012321113,
-0.0049672956,
0.027639253,
0.020535188,
-0.017260658,
-0.026515367,
0.014957387,
0.009289397,
0.03171854,
-0.0024472254,
-0.021006942,
-0.0015687565,
0.0021627853,
0.004446978,
0.004002974,
0.032523297,
-0.0011941281,
0.0013762391,
0.024336971,
0.012036673,
-0.012390488,
0.04137563,
-0.012466801,
0.005151141,
0.010794848,
-0.030886032,
0.0015479438,
0.024059469,
-0.0036560958,
0.006195244,
-0.016677903,
0.00014514683,
0.082418256,
0.03718534,
-0.0039162547,
-0.0076382575,
-0.005799803,
0.027056497,
0.034771066,
0.0036560958,
0.01540139,
0.00057841936,
0.00660456,
0.015692769,
-0.010441033,
-0.020535188,
-0.026432116,
0.007534194,
-0.009462836,
0.009837464,
-0.009566899,
-0.030220026,
0.03746284,
-0.0030386527,
0.026612492,
0.019092174,
-0.022866208,
0.005556988,
0.016109021,
-0.011551043,
0.0000026913544,
-0.02949852,
0.015970271,
-0.0020396437,
-0.03746284,
-0.0048493566,
0.019536179,
-0.013021806,
-0.01699703,
-0.007894947,
0.020521313,
0.02086819,
0.02360159,
-0.006146681,
-0.020451937,
-0.025238855,
-0.012466801,
0.003550298,
-0.014943511,
-0.02562736,
-0.017219033
] |
BACKGROUND Although numerous signaling pathways are known to be activated in experimental cardiac hypertrophy, the molecular basis of the hypertrophic response inherent in human heart diseases remains largely unknown. Integrin-linked kinase (ILK) is a multifunctional protein kinase that physically links beta-integrins with the actin cytoskeleton, suggesting a potential mechanoreceptor role. METHODS AND RESULTS Here, we show a marked increase in ILK protein levels in hypertrophic ventricles of patients with congenital and acquired outflow tract obstruction. This increase in ILK was associated with activation of the Rho family guanine triphosphatases, Rac1 | [
-0.031020459,
-0.011491251,
-0.005890335,
-0.023469253,
-0.022995658,
0.018667528,
-0.0364668,
0.0003753403,
-0.015404985,
-0.01169516,
0.003880846,
-0.012800215,
-0.0019766004,
-0.00079466903,
-0.0070513003,
-0.011820137,
0.027126456,
-0.004331419,
-0.007478851,
0.018417574,
-0.034677662,
0.036940392,
0.0070841885,
-0.024311198,
-0.014984013,
0.018115,
0.014299931,
-0.044070624,
-0.0020686884,
-0.021706427,
-0.013721094,
0.010333575,
-0.017365143,
-0.0013163632,
-0.017115189,
-0.0025324165,
0.019772582,
-0.0032625417,
0.012622616,
-0.008327375,
0.013017279,
0.005515406,
0.0068079247,
-0.032835905,
-0.009267987,
0.004509017,
0.011096588,
-0.028941903,
-0.020851325,
0.027152767,
0.008866747,
0.015602317,
-0.00044769506,
0.010938724,
-0.004597816,
-0.02404809,
0.017128345,
-0.001708559,
0.018904325,
-0.028941903,
-0.0072880974,
-0.0051503433,
-0.029283945,
0.015128722,
0.010655883,
0.017786115,
-0.02754743,
0.008583905,
0.0015860492,
0.0059462455,
0.03838749,
0.023956003,
-0.025784604,
0.01000469,
0.00025221388,
-0.020154089,
-0.017759804,
-0.01991729,
-0.013365897,
0.019325297,
0.0061501544,
-0.03144143,
0.006386952,
0.024666395,
0.007274942,
0.0030421887,
-0.02083817,
0.023495562,
0.002109799,
-0.016575817,
-0.002969834,
0.010155977,
0.0063639297,
0.009340341,
-0.021048658,
-0.009912602,
-0.013208033,
0.012359508,
-0.0011617872,
-0.017786115,
-0.0054068738,
-0.01983836,
-0.0002666026,
-0.016431108,
-0.037598163,
0.0013648738,
-0.0036473377,
0.0034927614,
0.03401989,
0.004732659,
-0.023758672,
0.035993204,
0.010287531,
-0.02098288,
0.0201804,
-0.02696859,
0.011024234,
0.02414018,
0.007077611,
-0.0036078712,
0.026442375,
0.02324561,
0.012063512,
-0.008176087,
0.019877825,
0.017904514,
0.0011954979,
-0.007005256,
-0.028757727,
-0.0038348022,
0.00015724827,
-0.000925812,
-0.010044156,
0.0047754142,
-0.008939101,
0.013944735,
0.0037558698,
-0.0153786745,
0.0027823693,
-0.040781774,
0.0000017761089,
0.009866558,
-0.0077024926,
-0.0022479307,
-0.015115567,
0.0031457876,
0.0032526753,
0.010794015,
0.0051273215,
0.009932335,
-0.002275886,
-0.0043347077,
-0.002067044,
-0.013615849,
-0.006097533,
0.017404608,
-0.017180966,
0.00977447,
0.0044531063,
0.0027971691,
-0.0055647385,
0.0026952147,
0.0034006736,
0.0063474854,
0.037335057,
0.009024612,
0.013878958,
-0.004999056,
0.012800215,
-0.014510417,
-0.013668472,
0.03617738,
-0.03465135,
0.014405174,
0.0055713165,
0.010767704,
0.00043495075,
-0.00055787165,
-0.026100334,
-0.021259144,
-0.02579776,
0.024034934,
0.0017957136,
0.004351152,
-0.0023729072,
-0.0050944327,
0.035046015,
-0.014944546,
0.0022676638,
-0.012780481,
-0.00644944,
0.026850194,
-0.025100524,
-0.024271732,
-0.62893385,
-0.026100334,
0.015155033,
0.0059265126,
0.0051437654,
0.04167634,
0.006337619,
0.0017578917,
-0.0017677583,
0.015115567,
-0.025745139,
0.012793637,
0.011589916,
-0.008820702,
-0.02754743,
-0.021417009,
0.006143577,
-0.036808837,
0.0139842015,
-0.006140288,
-0.002395929,
-0.016720526,
0.012142444,
0.017523007,
0.0032872083,
0.029020835,
0.03907157,
-0.014668283,
-0.002877746,
0.038597975,
-0.01476037,
0.017180966,
-0.006511928,
0.0076367157,
0.05409505,
-0.017549317,
-0.022640461,
0.027942091,
0.0129646575,
0.04683326,
-0.0058837575,
-0.004801725,
0.047622588,
0.007228898,
-0.019535786,
0.016957324,
0.015825959,
0.0105637945,
-0.0029945003,
0.0021245987,
-0.005653538,
-0.019114811,
-0.03725612,
0.014128911,
-0.0008168688,
-0.009781048,
0.018641217,
-0.005712737,
0.0017726916,
0.0047787027,
-6.9856003e-7,
0.039624095,
-0.015983824,
-0.0059791342,
0.014970857,
-0.007649871,
-0.008057689,
0.006340908,
0.0036506264,
0.01797029,
0.026034558,
0.03562485,
0.022508908,
0.011274187,
0.015181344,
0.01874646,
-0.0035388055,
0.024666395,
-0.004597816,
-0.0006318708,
-0.00064132625,
-0.00013936513,
-0.009412697,
0.010221754,
0.020088311,
0.024574308,
-0.023916537,
0.030362688,
0.0033020081,
0.000775347,
0.0035355166,
-0.018970102,
-0.03204658,
-0.03273066,
-0.012879147,
0.023995468,
-0.011938535,
0.015773337,
-0.00044687284,
-0.012642349,
-0.013168566,
-0.0023153522,
-0.03494077,
0.0047754142,
0.0010565439,
-0.0033612074,
-0.04130799,
0.0014495618,
0.05346359,
-0.037387677,
0.0034204067,
-0.016181154,
-0.011287342,
-0.0038775573,
-0.0011395875,
-0.027468497,
0.008840436,
0.015062945,
0.01539183,
-0.01814131,
0.020575061,
-0.01338563,
0.037203502,
-0.0065941494,
0.03012589,
0.012839681,
-0.012760748,
-0.01393158,
0.0018993124,
-0.007978757,
-0.0020045557,
-0.017667716,
0.028047334,
-0.013497451,
0.013971046,
0.016049601,
0.025297854,
0.01441833,
0.012655505,
-0.021653805,
-0.02886297,
-0.008320797,
0.008301064,
-0.01338563,
-0.015128722,
-0.011011079,
-0.022258954,
-0.0053970073,
0.012852836,
0.008353686,
0.014168377,
-0.013142255,
-0.010215176,
-0.0026935702,
0.016049601,
-0.027047524,
0.010011268,
-0.017562473,
-0.00024316955,
-0.033572607,
0.0007395807,
0.011787248,
-0.03430931,
0.0003362852,
0.00022775304,
-0.016825771,
-0.004624127,
-0.027073834,
-0.008208976,
-0.03204658,
-0.0059824227,
-0.014944546,
-0.029862782,
-0.00036896815,
0.0073999185,
-0.0001558094,
0.011478095,
-0.025534652,
-0.019680494,
0.00007903524,
0.015786493,
-0.03970303,
-0.01137943,
0.008379997,
0.029573362,
0.023798138,
0.019588407,
0.036151066,
0.0077551147,
0.027021213,
-0.030336376,
0.021706427,
-0.012030623,
0.023061434,
0.010017845,
-0.026468687,
0.03528281,
0.002433751,
-0.005242431,
0.022508908,
0.011649116,
-0.028073646,
0.014891924,
-0.015562851,
0.008307641,
-0.0074591176,
-0.008149777,
-0.023271922,
0.020943414,
-0.0024057957,
-0.0015811159,
0.041150123,
0.0043215523,
0.0004084344,
0.012471329,
0.012339775,
-0.014668283,
-0.0123331975,
-0.010794015,
-0.019785738,
0.0035815604,
-0.008333952,
0.018667528,
-0.008024801,
0.004370885,
0.014957702,
0.0037098257,
0.044833638,
0.0086694155,
-0.02069346,
-0.0091167,
0.019075345,
0.01321461,
0.032546487,
-0.013773715,
0.010208598,
0.0014857391,
-0.0061205546,
0.040202934,
0.0072946753,
0.019141123,
0.016549507,
-0.017917668,
0.00060309336,
0.0072157425,
0.0012785415,
0.024245422,
0.017273054,
-0.013839492,
0.03167823,
0.011517562,
0.03273066,
0.0024041513,
0.0041834204,
0.010320419,
-0.024284888,
0.02020671,
0.025955625,
0.047333166,
0.02158803,
0.010392774,
-0.0053641186,
0.0081695095,
-0.0056699817,
-0.001997978,
0.022324732,
-0.006627038,
0.0031770316,
-0.0058410023,
-0.0048773685,
-0.010826902,
0.010103355,
0.009465318,
-0.034230378,
0.010458551,
-0.0035585386,
0.02258784,
0.0086694155,
0.003992667,
0.012925191,
0.0042097312,
-0.050069492,
0.019193744,
0.01074797,
-0.0068671242,
-0.009925758,
-0.024495374,
0.002915568,
-0.002981345,
0.03433562,
-0.008754926,
0.0074920063,
0.029073458,
-0.02198269,
-0.0012004313,
-0.00455835,
0.029915404,
0.0017069145,
0.036440488,
-0.018036067,
-0.006577705,
0.014326242,
-0.013438252,
-0.016391642,
0.047885694,
0.018772772,
-0.0056338045,
-0.0071236547,
0.000031295487,
-0.009531095,
0.01226742,
-0.011412319,
0.00475897,
-0.020535596,
-0.006686237,
0.0047392366,
0.025232077,
-0.00331023,
0.022890415,
-0.003499339,
-0.017312521,
-0.039913516,
-0.025745139,
-0.0073275636,
0.02307459,
0.011504406,
0.009912602,
0.020943414,
-0.0034236957,
-0.0034894727,
-0.016431108,
-0.03041531,
0.0030388997,
-0.014168377,
0.010761126,
-0.02387707,
0.007912979,
-0.0025176166,
-0.0077090706,
0.018417574,
0.009629761,
-0.019496318,
0.010622994,
-0.006584283,
0.011635961,
0.0070184115,
0.019601561,
0.04972745,
0.0021278877,
0.0006676371,
-0.0043840404,
0.0141026005,
0.01235293,
-0.03009958,
-0.013004123,
0.014484107,
-0.0026557485,
-0.0066171717,
-0.016733682,
-0.032336,
-0.0042886636,
0.013747404,
0.009333764,
0.014247309,
0.013083056,
0.0124647515,
0.0052621644,
0.009044345,
-0.008649683,
-0.008524706,
0.007031567,
0.023745516,
0.011478095,
-0.0018614905,
0.024968969,
-0.020101467,
-0.009077233,
-0.02688966,
0.022114245,
-0.018904325,
0.020548752,
-0.012037201,
-0.0026590372,
-0.027521119,
-0.0061468654,
-0.006225798,
0.00897199,
-0.027442187,
0.005206254,
-0.006176465,
-0.0041899984,
-0.011846447,
-0.040281866,
0.0030980993,
0.008939101,
-0.03107308,
-0.015352364,
0.002083488,
0.032151822,
0.005068122,
0.008800969,
-0.002341663,
0.015510229,
0.020851325,
-0.013115944,
-0.008833858,
-0.0016427819,
-0.039808273,
-0.017694026,
-0.008958834,
-0.01843073,
-0.022219488,
0.021548562,
-0.002657393,
0.022640461,
-0.024205955,
0.003359563,
-0.02370605,
0.015089256,
0.0129646575,
0.020969724,
-0.0002565305,
0.012629194,
-0.011241298,
-0.017470386,
-0.026810726,
-0.020101467,
-0.009485051,
-0.009110122,
-0.012247687,
-0.0000046634905,
-0.00825502,
-0.00093485636,
0.0022117533,
-0.0017990024,
-0.006932901,
-0.01000469,
0.0044235066,
0.020864481,
0.043860137,
0.014668283,
-0.0040946216,
-0.00009676421,
-0.02032511,
-0.019101657,
0.0023054858,
0.0071894317,
-0.0049891896,
-0.027600052,
0.010767704,
0.026547618,
-0.0058541577,
-0.007518317,
-0.004147243,
-0.0077419593,
0.02560043,
-0.010011268,
-0.02648184,
-0.027310632,
0.007991912,
-0.03659835,
-0.0019618005,
-0.004824747,
-0.008833858,
0.010471707,
0.007788003,
0.020246176,
-0.01504979,
0.014378863,
-0.03709826,
-0.02640291,
0.024955813,
-0.0153786745,
-0.006893435,
-0.010379619,
0.011050545,
0.0030076557,
0.00041460097,
-0.03386203,
-0.05059571,
-0.0108137475,
-0.00882728,
0.027626362,
0.030046958,
0.02385076,
-0.009813936,
0.02502159,
0.0139842015,
0.0062915753,
-0.015510229,
-0.0023630406,
-0.010379619,
-0.042834017,
0.038255934,
0.015957514,
0.0021624207,
0.033756785,
0.006337619,
0.010498018,
-0.0005804825,
-0.0025472164,
-0.0068671242,
-0.004890524,
-0.035046015,
0.0018549128,
0.010590105,
-0.022850947,
-0.009037767,
-0.037019324,
-0.010761126,
0.009971801,
-0.020996036,
-0.008860169,
0.0041867094,
0.0030454774,
-0.04485995,
0.042570908,
-0.013129099,
0.009965223,
0.008123466,
-0.0100573115,
0.00025509164,
0.022824638,
0.016838925,
0.020285644,
0.010050734,
-0.0059528234,
-0.0032033424,
-0.004999056,
-0.0023285076,
-0.017351987,
-0.0053246524,
-0.023035124,
-0.027284322,
0.015852269,
-0.038834773,
-0.017128345,
-0.034361932,
0.0076038274,
0.021232832,
-0.03496708,
0.013760559,
0.00888648,
0.007972179,
0.023798138,
0.0027675694,
0.024074402,
-0.015786493,
0.01631271,
0.036045823,
0.009866558,
-0.0048839464,
0.0019453564,
0.004663593,
0.025100524,
0.039913516,
0.0023827737,
-0.021140745,
-0.019377919,
0.0016838926,
0.020588217,
-0.035914272,
-0.019680494,
0.022943037,
-0.010425663,
0.011024234,
-0.0061238436,
-0.013865802,
-0.023469253,
0.015852269,
0.0073933406,
-0.0036506264,
-0.00050196116,
0.0049826116,
-0.021364387,
0.02886297,
0.0024913058,
0.029283945,
0.014352553,
-0.03617738,
-0.0054364735,
-0.0008929235,
-0.008432618,
0.004351152,
0.013642161,
0.022245798,
-0.0070381444,
0.002187087,
0.019956758,
-0.000020632411,
0.03970303,
-0.009267987,
-0.007498584,
0.043412853,
-0.0006289931,
-0.00013474018,
0.010063889,
-0.02307459,
0.02069346,
-0.009064077,
0.008307641,
-0.027415875,
-0.023495562,
-0.0023729072,
0.021140745,
0.004104488,
0.0039400454,
0.011530717,
-0.03073104,
-0.001697048,
-0.021377543,
-0.013589539,
-0.0075577833,
-0.06509297,
-0.016694216,
-0.018496508,
0.012550262,
0.008320797,
0.017904514,
0.004581372,
0.011734626,
0.028441997,
-0.028678795,
0.007209165,
-0.0065744165,
-0.017365143,
-0.020732926,
-0.004265642,
-0.00862995,
0.0019585118,
0.007866936,
-0.0051207435,
-0.035440676,
-0.011142633,
-0.006199487,
0.015023479,
-0.0006088488,
0.019312143,
0.027442187,
-0.015023479,
0.0047359476,
0.017904514,
0.0040880437,
0.023337698,
-0.03362523,
-0.0011913868,
0.018956946,
-0.018983258,
-0.008182665,
-0.011629383,
0.000013007669,
-0.014181533,
-0.0059199347,
-0.033388432,
-0.013129099,
-0.002244642,
-0.016733682,
0.0017694028,
-0.030704727,
-0.025074212,
-0.039492544,
0.005887046,
0.017128345,
-0.014049978,
-0.01522081,
0.029941713,
0.011122899,
0.02066715,
-0.025008436,
0.0026721929,
0.010859791,
-0.012379241,
-0.015825959,
0.0065481057,
-0.01089268,
0.047227923,
0.005249009,
-0.0130962115,
-0.028994525,
-0.0023827737,
-0.06556657,
-0.03012589,
-0.0008164577,
0.007722226,
-0.01178067,
-0.010123088,
-0.0003977456,
0.006176465,
-0.012563417,
-0.005995578,
-0.0042491974,
-0.015102412,
0.02450853,
-0.006656638,
0.01249764,
-0.009498206,
-0.0018499796,
-0.013188299,
0.029678605,
-0.006380374,
-0.0044267955,
0.03846642,
-0.01539183,
0.00937323,
-0.0061501544,
0.022127401,
-0.015852269,
0.011261031,
0.036966704,
-0.02757374,
0.006067933,
0.020285644,
0.014891924,
-0.008084,
0.03709826,
-0.0030421887,
0.021127589,
0.022061624,
0.0077353814,
-0.03299377,
0.00020863659,
-0.012063512,
0.02854724,
-0.004555061,
-0.016141688,
0.011188677,
-0.000960345,
0.00033566853,
-0.0028415688,
0.0020357997,
-0.0060416223,
-0.00455835,
0.018246554,
-0.013030434,
-0.017759804,
0.003050411,
-0.0032526753,
-0.017154654,
-0.01651004,
0.020338265,
0.00067873695,
-0.025403097,
0.0026294377,
-0.0069789453,
-0.009702115,
-0.016904702,
-0.006308019,
-0.0038117801,
-0.021377543,
-0.008222132,
0.014326242,
-0.0015309609,
-0.024179645,
0.014023667,
-0.006209354,
-0.0016066046,
-0.014681438,
-0.02511368,
-0.01857544,
0.008195821,
0.20175138,
-0.011543873,
0.0024074402,
0.0063935295,
-0.009491629,
0.0024666395,
-0.004933279,
-0.001215231,
-0.0062817084,
-0.006873702,
0.0071762763,
0.007143388,
-0.00062734867,
-0.005893624,
0.0044037737,
-0.0021509095,
0.016865237,
0.004755681,
-0.014115755,
0.0034730283,
0.017470386,
0.0011478096,
0.015299742,
0.0013656961,
0.03967672,
-0.0091693215,
-0.031020459,
0.0053180745,
0.025179455,
0.0018927347,
-0.03751923,
0.005341097,
-0.0028317021,
0.0028958349,
0.015076101,
-0.008136622,
-0.007340719,
0.010544062,
0.020864481,
0.006495484,
0.010484862,
-0.0033003637,
-0.005716026,
0.0024189511,
-0.004370885,
0.005005634,
0.012609461,
-0.027784226,
0.008432618,
0.020627683,
-0.046570152,
0.00472937,
0.020219866,
0.013971046,
-0.001986467,
-0.011320231,
0.012504218,
0.02256153,
0.005508828,
0.012662083,
-0.011182099,
-0.0025011725,
-0.0036045825,
0.019496318,
-0.046280734,
0.045096748,
-0.012287154,
0.009333764,
-0.0028876127,
-0.006183043,
0.0037591585,
-0.010287531,
-0.008406308,
0.0018006468,
-0.01986467,
-0.016352175,
0.023508718,
-0.007071033,
0.030362688,
0.020825015,
0.023061434,
-0.002881035,
-0.027021213,
-0.006337619,
-0.024758482,
-0.01587858,
0.02256153,
0.012254265,
-0.0073933406,
-0.011491251,
-0.0014150288,
-0.0022150422,
-0.019193744,
-0.014812992,
0.026139801,
0.0030224556,
-0.0067947693,
-0.002634371,
-0.011149211,
-0.001708559,
0.0025373497,
0.060462266,
0.012372663,
-0.01536552,
-0.023613961,
-0.011662272,
-0.013878958,
0.004035422,
-0.0042228866,
-0.024784794,
0.006136999,
-0.037782338,
-0.001489028,
-0.018970102,
-0.019391075,
0.013957891,
0.019812047,
0.0068802796,
0.027784226,
-0.016694216,
-0.009642916,
-0.00089210126,
0.011267609,
0.023995468,
-0.0077485368,
0.018535974,
0.004693193,
0.01991729,
0.012451596,
-0.029652296,
0.0040518665,
0.016615283,
0.0023317966,
0.0025422832,
0.019956758,
0.01049144,
0.015668094,
-0.0060120225,
-0.009452162,
0.024613773,
-0.0024386842,
-0.0031885426,
0.019706804,
0.031283565,
0.005755492,
-0.015957514,
0.026192423,
0.03299377,
0.0038348022,
-0.013510606,
0.009570561,
-0.015904892,
0.014168377,
-0.024232266,
0.031020459,
-0.027678983,
-0.010333575,
-0.0058574467,
0.0065020616,
-0.005801536,
-0.0018072245,
0.0036802262,
0.015457608,
-0.015326053,
-0.03012589,
-0.0064165513,
-0.16470574,
-0.0005529383,
0.023153523,
-0.011550451,
0.01894379,
0.009485051,
0.0047852807,
-0.015641782,
0.0043675965,
0.026166111,
0.03230969,
-0.0057686474,
-0.023271922,
-0.04009769,
0.006646771,
0.0056732707,
0.0035749828,
0.009149588,
0.002496239,
-0.0075314725,
0.013892113,
-0.018601751,
0.02983647,
-0.001662515,
0.0030849439,
0.007932712,
-0.0030652105,
-0.02657393,
0.0056403824,
-0.02599509,
-0.0017184255,
0.011550451,
0.036677286,
-0.015141877,
0.0040189778,
-0.0075577833,
0.0078077363,
-0.012458174,
-0.0060416223,
0.013063323,
0.03141512,
0.040834393,
0.012681816,
0.010011268,
-0.019009568,
0.02786316,
0.0013936514,
0.0028563684,
0.024600618,
-0.023061434,
0.017838737,
-0.015444452,
0.011899069,
0.017391453,
0.03109939,
0.020390887,
-0.0119582685,
0.010498018,
-0.006317886,
-0.007728804,
-0.012576573,
0.003749292,
0.024587462,
-0.012780481,
0.0040913327,
-0.0029829894,
-0.010116511,
0.0063310415,
-0.033783093,
0.0070184115,
0.00031757983,
-0.029099768,
0.0057489146,
-0.024745326,
0.018022912,
0.018036067,
0.0003784236,
-0.0026179268,
-0.013497451,
0.014826148,
-0.021061812,
0.019180588,
-0.029389188,
-0.039887205,
-0.01774665,
0.011320231,
0.0005767825,
0.020154089,
0.015904892,
-0.0042294646,
0.019798893,
-0.053016305,
0.0043906183,
-0.000066907596,
0.02118021,
0.012622616,
-0.011537295,
0.00025139167,
0.0039400454,
0.012530529,
0.01986467,
-0.012938346,
0.00021644762,
0.024890037,
0.018956946,
-0.008077422,
-0.0017726916,
0.008011645,
0.040939637,
-0.0038479576,
-0.010557217,
-0.016720526,
0.0065744165,
0.029415498,
-0.010123088,
0.019601561,
-0.011280765,
-0.0038446686,
0.010011268,
-0.038913704,
0.06488249,
0.010951879,
-0.01137943,
0.014997168,
-0.021969536,
-0.032678038,
-0.12113502,
-0.023469253,
0.030494241,
-0.0084128855,
0.009064077,
0.01983836,
0.008860169,
0.008090577,
-0.0019766004,
0.02453484,
-0.045333546,
0.0030684995,
0.0033431186,
-0.009596872,
0.022903569,
0.009892869,
0.021193366,
-0.014142066,
-0.019969912,
0.02912608,
-0.010116511,
-0.005548294,
-0.015036634,
-0.0021081546,
-0.0043939073,
0.0008649682,
-0.047491033,
0.030941525,
0.0067322813,
-0.0003383407,
0.04072915,
0.004663593,
0.011978001,
-0.0049135457,
-0.021522252,
-0.009827091,
-0.015062945,
-0.012865991,
0.035440676,
-0.0074393847,
0.018706994,
0.022351043,
0.022219488,
-0.03265173,
-0.004620838,
0.013267231,
-0.020140933,
0.008800969,
0.023995468,
-0.02227211,
-0.011708315,
-0.03241493,
-0.03886108,
0.0024123734,
0.02757374,
-0.026652861,
-0.0062817084,
0.011563606,
-0.03494077,
0.008511551,
-0.024811104,
0.0022314866,
-0.015589162,
-0.011359697,
0.031178324,
-0.028889282,
-0.010853213,
-0.044254802,
0.035835337,
-0.0060383333,
-0.004134088,
0.014326242,
-0.022982502,
0.005377274,
-0.02385076,
0.0064856173,
-0.034493487,
-0.0008764792,
0.0068473914,
-0.014207844,
-0.020482974,
-0.023114055,
0.018680682,
0.00062200427,
0.002545572,
0.008853591,
-0.027126456,
-0.009767893,
0.01539183,
-0.012293731,
-0.008689148,
0.026810726,
0.02110128,
0.0039433343,
0.00081563543,
0.010761126,
-0.009531095,
-0.013615849,
0.02040404,
0.026547618,
-0.040281866,
0.004926701,
-0.06267238,
0.02118021,
0.007788003,
0.016917858,
0.0024074402,
-0.009636338,
-0.010300687,
-0.0034565842,
0.019667339,
0.012089822,
-0.018851703,
0.01825971,
-0.009346919,
0.00232193,
-0.029073458,
-0.012826526,
0.023995468,
-0.0134711405,
0.0059462455,
0.01665475,
-0.0013064967,
-0.006538239,
0.0050779884,
0.025363632,
0.0136026945,
-0.012168755,
-0.016957324,
0.0062159314,
-0.010333575,
-0.0011601427,
0.004647149,
-0.058357403,
-0.012925191,
0.012431863,
-0.008215554,
-0.039308365,
-0.015576006,
0.035124946,
0.0030438332,
0.02548203,
-0.008373419,
-0.020167245,
0.0071960096,
-0.0005689715,
0.012024045,
0.007097344,
-0.03625631,
-0.0037821806,
-0.0049201236,
-0.019904137,
0.020022536,
0.00455835,
-0.013878958,
-0.033388432,
-0.021114433,
0.008708882,
0.017707182,
-0.01289888,
0.0055022505,
-0.007728804,
0.004597816,
-0.0041571097,
0.008130044,
0.020154089,
0.002668904,
-0.02000938,
-0.037071947,
0.010642727,
0.020653995,
-0.0115767615,
-0.027942091,
0.0028596574,
0.009524517,
0.010728237,
0.003158943,
0.01186618,
-0.0131027885,
-0.009886291,
-0.018391265,
0.0056995815,
0.027652673,
0.005584472,
-0.018996412,
-0.008728615,
0.0072223204,
-0.014786681,
0.002067044,
0.039545164,
0.02513999,
0.006100822,
0.0033036524,
0.018207088,
0.004663593,
-0.0034105403,
0.016378487,
0.02883666,
-0.008294486,
-0.002244642,
-0.005337808,
0.020996036,
0.007985334,
-0.006136999,
-0.0073999185,
-0.026074024,
0.010017845,
-0.0038282245,
-0.011899069,
-0.029783849,
-0.020877637,
-0.0084194625,
0.038834773,
0.0036012935,
0.018338643,
0.0130962115,
-0.013464563,
-0.00074698066,
0.009682382,
-0.019667339,
-0.008656261,
0.039255746,
0.0022166867,
-0.012609461,
-0.014392019,
-0.0044070627,
0.0026935702,
0.0048707905,
0.028441997,
-0.004236042,
0.018693838,
0.0047162147,
0.010780859,
0.0046076826,
-0.006492195,
-0.010616416,
0.0037624475,
-0.0153786745,
-0.00768276,
0.017865047,
-0.003775603,
0.0909302,
0.00021418653,
-0.012076667,
0.022180023,
-0.014944546,
0.014378863,
-0.00050319446,
0.004693193,
-0.05096406,
-0.033099014,
-0.014484107,
-0.020193554,
0.035203878,
-0.025837226,
-0.014944546,
0.0039104456,
0.016273243,
0.00028880237,
0.022245798,
-0.02000938,
-0.016865237,
-0.019193744,
-0.0068013472,
0.022916725,
-0.033256877,
-0.0065711276,
0.020719772,
0.0035388055,
-0.0069921007,
-0.02207478,
0.021430165,
0.007866936,
-0.028573552,
-0.004301819,
0.010517751,
-0.023548184,
-0.001928912,
-0.0009776114,
0.002978056,
0.0035815604,
-0.018483352,
0.008939101,
-0.020377731,
-0.0352565,
-0.0022281976,
-0.0042524864,
-0.02052244,
0.0068671242,
-0.023548184
] |
To shed further light on the primary alterations of insulin secretion in type 2 diabetes and the possible mechanisms involved, we studied several functional and molecular properties of islets isolated from the pancreata of 13 type 2 diabetic and 13 matched nondiabetic cadaveric organ donors. Glucose-stimulated insulin secretion from type 2 diabetic islets was significantly lower than from control islets, whereas arginine- and glibenclamide-stimulated insulin release was less markedly affected. The defects were accompanied by reduced mRNA expression of GLUT1 and -2 and glucokinase and by diminished glucose oxidation. In addition, AMP | [
-0.022401035,
-0.02287506,
0.021371724,
-0.032152392,
-0.0041070823,
0.02043722,
-0.022644818,
0.0006149619,
-0.05395751,
-0.02337617,
0.0098935645,
0.03770525,
0.0012476997,
0.0013238821,
-0.003201357,
-0.003048992,
0.032585785,
0.0097445855,
-0.002441225,
0.011586509,
-0.023281366,
0.010360817,
0.0056171883,
0.004835048,
-0.0005548624,
0.009622694,
-0.007868804,
-0.024960766,
-0.00876945,
-0.01124792,
0.006616025,
0.01311693,
-0.029795814,
0.0031844277,
-0.000071897215,
-0.00930442,
-0.008126131,
0.016022021,
0.014112381,
-0.015060429,
0.0054241926,
0.007069734,
0.0027967435,
-0.0020924788,
-0.001997674,
0.009724271,
0.021778032,
-0.01075358,
-0.015873043,
0.008126131,
-0.00084943464,
0.013855053,
-0.009676868,
-0.016116826,
-0.013069527,
-0.015683433,
0.0010479323,
0.011938641,
0.004628509,
-0.021019593,
0.0072458005,
0.007902662,
-0.02253647,
0.0097445855,
0.0054309643,
0.0126361335,
0.0064941333,
0.0034942364,
0.00405968,
0.0033300207,
0.030852212,
0.018960973,
-0.012900233,
0.00001928369,
0.031746086,
-0.010875472,
-0.0040122773,
-0.019502714,
-0.0051330063,
0.004733471,
0.02211662,
-0.016184544,
-0.019570433,
0.03488819,
0.0021483458,
-0.005891445,
0.0003936095,
0.010387904,
-0.020504937,
0.0069681574,
0.0062334198,
0.015913673,
0.034779843,
0.031231431,
-0.016008478,
0.00621649,
-0.004584492,
0.02890194,
-0.0031370253,
-0.007807858,
-0.014004032,
0.0047300854,
-0.0028881624,
-0.017105507,
-0.009270561,
0.019814216,
-0.005041587,
-0.011999587,
0.016184544,
0.012405894,
-0.0048485915,
0.04629186,
0.0038565265,
-0.030906385,
0.0062232623,
0.006375627,
0.020017369,
0.0038057382,
0.002806901,
-0.0093721375,
0.012013131,
-0.0029863531,
0.033913054,
-0.015426106,
0.0065347636,
0.00033858878,
0.009385682,
-0.00911481,
-0.015629258,
-0.008139675,
0.0080651855,
0.0018199148,
0.036242545,
0.00028780047,
-0.0016226869,
0.02009863,
-0.019583976,
-0.0014042971,
-0.0065110624,
-0.041876663,
-0.013577411,
0.02684332,
-0.006341768,
0.013482606,
-0.018243164,
0.019624606,
0.020003825,
-0.0033689586,
0.0046996125,
0.01776914,
-0.010591057,
-0.024852417,
-0.008613699,
-0.014342621,
0.039790954,
0.017755596,
0.0046759113,
0.035131972,
-0.03404849,
-0.011430758,
-0.0060201087,
-0.01883908,
-0.0016827863,
-0.007191626,
0.032260742,
0.021331094,
0.0025123288,
-0.008261567,
0.0057221507,
-0.0073812357,
-0.014085294,
0.009020005,
-0.0011512019,
0.023592867,
-0.009527889,
0.031962782,
0.013076299,
0.01239235,
-0.012642906,
-0.005170251,
-0.03161065,
0.033885967,
0.00020410556,
0.016523134,
-0.016306436,
-0.0072458005,
0.01678046,
0.010008684,
0.01426136,
-0.017660791,
0.0054817526,
0.0032538383,
-0.025556682,
-0.012744483,
-0.6383889,
-0.03721768,
0.022753168,
-0.009182529,
-0.021439442,
0.031637736,
0.00484182,
0.0074083228,
-0.033262964,
0.01967878,
0.010232153,
0.021913467,
-0.0019147196,
-0.02543479,
-0.0124668395,
-0.023457432,
-0.01822962,
-0.016956527,
0.022360405,
-0.01776914,
-0.013577411,
0.00009205383,
0.011904782,
0.011735488,
0.028793592,
0.02234686,
0.012995038,
-0.015426106,
-0.014613492,
0.033913054,
-0.022739623,
0.021561334,
0.006802249,
-0.008397002,
0.04778165,
-0.00895906,
-0.011092169,
-0.0015608943,
0.002751034,
0.04797126,
-0.005691678,
0.006555079,
0.014234273,
0.009717498,
-0.0055359267,
0.008722047,
-0.0012036832,
0.018717188,
0.00827511,
0.009074179,
0.022739623,
0.0028949343,
-0.02413461,
-0.004408426,
0.030906385,
-0.0038395969,
0.020396588,
-0.017240942,
0.021060223,
0.027032929,
0.015317757,
0.038301166,
-0.023890825,
-0.014166555,
0.012223056,
0.0077604554,
-0.008931972,
0.0056341174,
0.0136789875,
0.014721841,
0.023200104,
0.032450352,
-0.010536883,
0.030798037,
0.030310469,
0.030120859,
0.00857984,
0.016983613,
-0.010977048,
-0.00051465497,
-0.0040901527,
0.017647248,
-0.0037549497,
-0.0104149915,
0.016848179,
0.017335746,
-0.0011723638,
0.020586198,
-0.0048519773,
0.010462394,
0.0146676665,
0.0043474804,
-0.02150716,
-0.019949652,
-0.027506953,
0.039086692,
-0.010977048,
0.015534454,
0.022698993,
-0.027953891,
-0.020681003,
-0.00070257176,
-0.0005150782,
-0.007889119,
0.02692458,
0.011884467,
-0.03992639,
-0.018825537,
0.050056968,
-0.050896667,
0.027615301,
0.009047093,
-0.009988369,
-0.007035875,
0.017024245,
-0.022983408,
0.009717498,
-0.0075979326,
0.025976533,
-0.032748308,
-0.018500492,
-0.0043745674,
0.0074083228,
-0.009460171,
-0.000006222892,
0.014139468,
-0.009135126,
-0.0104149915,
-0.003595813,
-0.0105842855,
0.008512123,
0.00659571,
0.026789146,
-0.00049518613,
0.02436485,
-0.016834635,
0.025949445,
-0.004499845,
0.012378806,
-0.03938465,
0.00033435645,
0.008911657,
-0.0071442234,
-0.022319773,
0.014762471,
0.00281198,
-0.022103077,
-0.00459465,
0.02974164,
-0.018717188,
-0.004557405,
-0.022401035,
-0.013103386,
0.015629258,
0.01627935,
-0.014938538,
0.0053869477,
-0.028658155,
0.009480487,
0.024215871,
0.007950065,
0.035294496,
-0.015954304,
-0.01067909,
-0.027696563,
-0.023945,
-0.0056645907,
-0.00037011987,
-0.027845543,
-0.030933473,
-0.0054851384,
0.0067616184,
-0.0038666842,
0.021669682,
-0.002659615,
0.009405997,
-0.0128392875,
-0.007557302,
-0.008728819,
0.009805531,
0.01327268,
-0.002293939,
-0.010726493,
0.025339985,
0.034915276,
-0.0001869645,
-0.0033706515,
0.0045167743,
-0.014505144,
0.028387284,
-0.028495634,
0.016617939,
-0.0019485785,
0.021683227,
-0.019069321,
-0.013144017,
0.018473405,
-0.010841614,
-0.024486741,
0.011776119,
0.038409512,
-0.019854847,
0.00063654693,
-0.013279453,
0.022522926,
-0.036323804,
-0.0052955286,
-0.0222656,
0.03366927,
-0.0018097571,
-0.0015236496,
0.004777488,
0.006246963,
0.0065110624,
-0.0069241407,
0.0195298,
-0.013204963,
-0.0062638926,
-0.013949858,
-0.019489171,
-0.009805531,
0.018811993,
0.012873146,
-0.009643009,
-0.024635721,
0.029497856,
0.011857379,
0.00061792455,
-0.020450763,
-0.022238512,
-0.019231843,
0.000418792,
0.01071295,
0.00062596606,
0.0114781605,
0.019787129,
-0.0027561127,
-0.00030430668,
0.015561541,
0.019231843,
0.0075166714,
0.0104149915,
0.012074077,
0.014545775,
-0.0054275785,
-0.008518894,
0.025800467,
0.021832205,
-0.024446111,
0.024188783,
0.009311192,
0.013225279,
-0.0014677824,
0.0011401977,
0.0056612045,
0.012331404,
0.0197465,
0.0012476997,
0.021601966,
0.027818456,
0.0031200957,
0.013069527,
-0.00047571727,
-0.016441872,
-0.005044973,
0.031366866,
0.012202741,
-0.0019858233,
0.00038006593,
0.0069038253,
-0.03077095,
0.009433084,
0.00022325698,
-0.015832413,
0.013408116,
0.019814216,
0.004977255,
-0.012771569,
0.03228783,
-0.006443345,
-0.009670096,
-0.033154614,
0.020085087,
0.0025749677,
-0.0065347636,
-0.020978961,
-0.01529067,
-0.010387904,
0.008234479,
0.01151879,
-0.009290877,
0.005718765,
0.014572862,
-0.00284076,
-0.0024903207,
-0.0035314811,
0.02081644,
0.0054851384,
0.009940967,
0.008545981,
0.0032690747,
0.014857276,
-0.0197465,
-0.0052650557,
0.039601345,
0.020870613,
-0.0054952963,
-0.0044626,
0.00071357586,
-0.015818868,
0.0030845439,
0.00060861337,
0.0027967435,
-0.007042647,
0.023132386,
0.008803309,
-0.008986146,
0.0030591497,
0.027534042,
-0.0022279143,
-0.028197674,
-0.023579324,
0.0066295685,
-0.0016421557,
0.015629258,
0.029118637,
0.0035788836,
0.004472758,
0.01216211,
0.010205067,
-0.00023129847,
-0.019069321,
0.030472992,
-0.007225485,
0.010482709,
-0.00025013246,
0.02337617,
-0.01621163,
0.018053554,
0.010631688,
-0.021629052,
-0.031881522,
-0.000049359896,
0.007191626,
0.011322409,
-0.00014950811,
0.021669682,
0.024337763,
0.02028824,
-0.025516052,
-0.0105842855,
-0.011471389,
-0.0066532698,
-0.004811347,
-0.0032758466,
0.012256915,
-0.0022075989,
0.016604394,
-0.009554976,
-0.043610238,
0.014762471,
-0.0035111657,
0.029985424,
0.0063857846,
0.0025292584,
0.011200517,
0.01464058,
-0.0015702056,
-0.025353529,
-0.032775395,
-0.014559318,
0.023511605,
-0.023389714,
-0.007807858,
0.023945,
-0.025001397,
0.009575292,
-0.02806224,
0.00634854,
0.0120943915,
0.00876945,
-0.023741847,
-0.011227604,
-0.0044050403,
-0.008424089,
-0.007035875,
0.008735591,
-0.02169677,
-0.022834428,
-0.0070494185,
0.0026155985,
-0.010787439,
-0.013739933,
-0.0061792457,
0.033344224,
-0.013496149,
-0.010543655,
0.0031200957,
-0.00039932315,
0.0016777075,
-0.0023227192,
0.00045751812,
0.0134555185,
-0.00010734323,
-0.02379602,
-0.013963402,
0.009988369,
-0.0350778,
0.027344432,
0.0026105195,
-0.011688085,
-0.028360197,
-0.01566989,
-0.0016827863,
0.0021669683,
-0.027561128,
0.021452986,
-0.016983613,
0.00911481,
-0.0014373094,
0.027398605,
0.019705867,
-0.0013805958,
-0.0064839753,
0.0047029983,
-0.030147946,
-0.015182322,
-0.032937918,
-0.00979876,
0.0037346345,
-0.0033909667,
-0.012832515,
0.006135229,
-0.014098837,
0.0059997933,
-0.006409486,
0.010394676,
-0.006866581,
0.02459509,
0.020870613,
-0.02787263,
-0.001481326,
-0.0011291936,
-0.012372035,
-0.014803102,
-0.015967848,
0.03217948,
0.00911481,
-0.018473405,
0.017132593,
0.015250039,
-0.02890194,
-0.01772851,
0.009405997,
-0.014085294,
0.03115017,
-0.00562396,
-0.007137452,
-0.020748721,
-0.007943293,
-0.011735488,
0.009168984,
0.011464616,
0.003934402,
-0.013976946,
0.004127397,
0.009351823,
-0.013767021,
0.01608974,
-0.031475216,
-0.034481883,
0.0055494704,
0.01673983,
0.010557199,
-0.0057289223,
0.020559112,
-0.028224763,
0.0023091757,
-0.026775602,
-0.03077095,
-0.011931869,
-0.018933885,
0.0070900493,
0.040468134,
0.03637798,
0.015791781,
0.013394573,
0.021073766,
0.01468121,
0.043231018,
-0.002415831,
0.0011181895,
-0.024351306,
0.02085707,
-0.0097445855,
-0.016807549,
0.022698993,
-0.02474407,
0.035484105,
-0.01239235,
-0.0020450763,
-0.030175034,
-0.022008272,
-0.04209336,
-0.026585992,
0.010740036,
0.0012206126,
-0.019800672,
-0.036703024,
-0.025231637,
0.0051330063,
-0.0104353065,
-0.0041510984,
-0.013692531,
0.019570433,
-0.027317343,
0.04992153,
0.007909434,
-0.01227723,
-0.009216387,
-0.029145723,
0.0010860235,
-0.0052413545,
0.0080651855,
0.010089946,
-0.002475084,
0.014193642,
-0.033533834,
0.0010682476,
0.00019140847,
-0.025841096,
0.010164436,
-0.0016193009,
-0.013374258,
-0.0075979326,
-0.008424089,
-0.03228783,
-0.034373533,
-0.015575085,
0.013895684,
-0.019096408,
0.0072728875,
-0.013435204,
-0.0054004914,
0.01403112,
-0.012575188,
0.0342381,
0.0033774232,
-0.0016980228,
0.025042027,
-0.011633911,
-0.00009533391,
0.00459465,
0.007685966,
-0.004950168,
0.031583562,
0.00991388,
0.006531378,
-0.02825185,
0.013807651,
0.02356578,
0.0005468209,
-0.007096821,
0.019055778,
0.022482296,
-0.0046962267,
-0.02268545,
-0.02455446,
-0.028387284,
-0.0065042907,
-0.00888457,
-0.0010648618,
-0.0013941394,
0.009020005,
-0.024716983,
0.018094186,
0.018012924,
0.012426209,
0.011498475,
-0.013949858,
-0.009703955,
-0.03253161,
-0.012534557,
-0.0056679766,
-0.005647661,
0.007035875,
-0.02207599,
0.0016133756,
0.011715173,
0.01407175,
0.0051871804,
0.0057289223,
-0.017281571,
0.04000765,
-0.003568726,
-0.012595504,
0.0392763,
-0.0064772037,
-0.016103283,
-0.009886793,
-0.0026731587,
0.012521014,
-0.040116,
0.0010377746,
0.023674129,
0.038111556,
-0.015642803,
0.016171,
-0.020586198,
-0.010049315,
-0.021168571,
-0.017362833,
0.011200517,
-0.02650473,
0.002905092,
-0.02451383,
0.0026071337,
0.012683536,
-0.003115017,
0.0027120963,
0.017200312,
0.027479867,
-0.01250747,
0.012561644,
0.000642049,
-0.0021822047,
-0.011986043,
-0.004073223,
-0.018473405,
-0.014803102,
0.03253161,
-0.02657245,
-0.037380204,
-0.010015457,
0.0016904046,
0.009175756,
0.0148166455,
0.009047093,
0.0072390283,
0.017227398,
0.015168778,
0.011044767,
-0.0054783667,
0.018216077,
-0.0110312225,
0.003809124,
0.0057390803,
0.00039530243,
-0.015250039,
0.008992919,
-0.0041747997,
-0.014897907,
0.00911481,
-0.016753374,
-0.022604188,
0.008647558,
-0.021791575,
0.0053903335,
-0.013807651,
-0.012737711,
-0.014897907,
-0.00093027274,
0.019069321,
-0.007618248,
-0.044666633,
-0.013204963,
0.0023447275,
0.021791575,
0.0018757819,
-0.003924244,
-0.012859602,
-0.008322513,
-0.025746292,
0.0037007756,
-0.023470975,
0.028847765,
-0.012649678,
0.0035314811,
-0.032396175,
0.014180099,
-0.032071132,
0.0010030693,
-0.022956321,
0.017633704,
0.01445097,
0.011430758,
-0.007469269,
0.013739933,
0.0014136082,
0.027547585,
-0.035863325,
-0.021344637,
0.018595297,
-0.0031268676,
0.02871233,
0.008864255,
-0.01902869,
-0.026951669,
0.032206565,
-0.008715276,
0.0114781605,
-0.0005265056,
-0.007672422,
0.026707884,
-0.005674748,
0.022455208,
0.017823314,
-0.0059117605,
0.007882347,
-0.030716775,
-0.004716542,
0.0014169941,
-0.0009819075,
-0.0075979326,
-0.012378806,
0.0026646939,
0.008810081,
-0.0043779532,
-0.0120943915,
-0.0046589817,
-0.0042966916,
0.0018960972,
0.009507573,
0.013401344,
0.0052074958,
-0.0035145518,
0.009487258,
0.0019925951,
-0.015873043,
-0.0049433964,
-0.009656552,
0.011654226,
0.0011393513,
0.008688188,
-0.007564074,
-0.011139572,
-0.0014000647,
-0.036513414,
0.0024886276,
0.0085324375,
-0.011396899,
-0.023308452,
0.0023091757,
0.0072322567,
-0.017782684,
-0.0111802025,
0.00857984,
-0.011918326,
0.009507573,
-0.0041747997,
-0.0047605583,
0.0017369605,
-0.012730938,
-0.017389921,
-0.01655022,
-0.0050923754,
-0.01841923,
-0.027926804,
-0.034563143,
-0.007103593,
0.18570918,
-0.02322719,
0.031637736,
0.025096202,
-0.016848179,
-0.010482709,
0.008945516,
0.0024970924,
-0.008322513,
0.005285371,
-0.009013234,
-0.007069734,
-0.027547585,
-0.008701732,
0.006568623,
0.010049315,
-0.012338175,
0.0043948824,
0.009399225,
-0.005830499,
0.0076114764,
-0.01898806,
0.013597726,
0.0052718273,
0.044747896,
0.014112381,
-0.013909228,
-0.0039310157,
0.016143914,
0.039330475,
-0.0069004395,
0.028414372,
-0.007008788,
0.015778238,
0.0040088915,
-0.0021280306,
-0.0040698373,
-0.005227811,
0.015412562,
0.028197674,
-0.009703955,
-0.0002423026,
-0.029714553,
-0.013922771,
-0.0037278626,
0.0011046459,
-0.018811993,
-0.013936315,
0.0030896228,
-0.009785216,
-0.04864844,
-0.009080951,
0.016171,
0.008545981,
0.026247403,
-0.020112174,
0.022983408,
0.018243164,
0.0049129236,
0.007956836,
-0.030500079,
0.008038098,
-0.016455416,
0.035023626,
-0.033154614,
0.035673715,
-0.032937918,
-0.013821195,
0.02043722,
-0.020044457,
0.0058169556,
-0.009974826,
-0.0143697085,
-0.0076250196,
-0.009588835,
-0.008288654,
0.034752753,
0.023850195,
0.024662808,
-0.0016150685,
-0.012284001,
0.03488819,
-0.03589041,
0.0022482297,
-0.014599949,
-0.040901527,
0.023498062,
-0.008315741,
-0.01403112,
-0.0175389,
-0.0011681314,
-0.0054174205,
-0.020694546,
-0.020735178,
0.014098837,
-0.026762059,
-0.004977255,
0.008112588,
0.0054241926,
-0.040441047,
-0.0062740506,
0.08185723,
-0.0016887116,
0.016672112,
-0.015845956,
-0.0037041614,
-0.0108687,
0.0018182219,
0.015588628,
-0.004706384,
0.012412665,
-0.018771363,
-0.0023142544,
-0.029714553,
-0.01075358,
0.018202534,
0.021805119,
-0.030716775,
0.006382399,
-0.027845543,
-0.026518274,
-0.013408116,
0.009094495,
0.0062063327,
-0.013936315,
0.019299561,
-0.016915897,
0.0023514992,
-0.011302094,
-0.030743863,
0.00013469486,
-0.02417524,
-0.0011545878,
0.021466529,
-0.00094550924,
-0.012974722,
0.0026985528,
0.0037684932,
0.023552237,
0.020789351,
0.0040529077,
0.00064501166,
-0.00014432348,
-0.008634014,
0.013353942,
-0.014288447,
0.026531817,
-0.0128122,
0.0011977579,
-0.005231197,
-0.019231843,
-0.018730732,
0.006680357,
-0.017254485,
0.035240322,
-0.010794211,
-0.01776914,
-0.03892417,
-0.0007719825,
-0.0043339366,
-0.015994934,
0.02726317,
0.021588422,
0.0021026365,
-0.015426106,
-0.012060533,
-0.17173223,
0.025597313,
0.019651694,
-0.009934195,
0.023823109,
-0.0032132077,
-0.0014271517,
-0.0004022858,
0.006707444,
0.019732956,
0.026558906,
-0.019109951,
-0.03020212,
0.008512123,
0.005613802,
0.002414138,
-0.017674334,
0.029254071,
0.013374258,
-0.008749135,
0.015886586,
-0.023958543,
0.022956321,
-0.021344637,
0.000785526,
0.015222953,
0.008315741,
0.020992504,
-0.015236496,
-0.014410339,
-0.010963505,
0.023308452,
0.043176845,
-0.008634014,
0.024310676,
-0.0058067976,
-0.0234168,
-0.016821092,
-0.015453192,
0.0001446409,
0.035673715,
0.01875782,
0.0009387374,
-0.00046598283,
-0.022604188,
0.017945206,
0.019258931,
0.01875782,
0.02669434,
0.016496046,
0.020748721,
0.0059083747,
0.008789765,
0.02398563,
0.0034942364,
0.01636061,
-0.024527373,
0.014924994,
0.0025241794,
0.013265909,
-0.002210985,
-0.022671906,
0.03096056,
0.010313415,
0.0015939068,
-0.036432154,
0.011762574,
-0.0063688555,
-0.0006301984,
0.011640683,
-0.027615301,
-0.015940761,
0.010015457,
-0.027845543,
0.018825537,
0.018310882,
-0.006704058,
-0.0046386663,
0.0018334583,
-0.00743541,
-0.011762574,
0.011112484,
-0.03935756,
-0.02505557,
-0.012703852,
0.024689894,
0.012751254,
0.015520911,
0.0052176532,
0.022387492,
0.012500699,
-0.03943882,
0.006446731,
-0.019624606,
-0.00035932736,
0.031637736,
0.0035585682,
0.005542699,
0.028576894,
-0.011017679,
0.01487082,
-0.004804575,
-0.0052447403,
0.00839023,
0.00030536478,
0.00042514055,
-0.038788732,
-0.019990282,
0.022184338,
-0.009284105,
-0.010848385,
0.001574438,
0.0050619026,
0.01136304,
-0.009385682,
0.040441047,
0.0048621353,
-0.0060302666,
0.023836652,
-0.040468134,
0.060079195,
0.0017995995,
0.005654433,
0.009074179,
-0.012798657,
-0.035104886,
-0.13402699,
-0.05742466,
0.023660585,
0.024568003,
0.0020095245,
0.015317757,
0.025082657,
0.020789351,
-0.012378806,
0.033642184,
-0.032585785,
0.013333627,
0.014897907,
-0.0021297236,
0.022550013,
0.012256915,
-0.00068098673,
-0.005860972,
-0.028387284,
0.03115017,
-0.003324942,
-0.011539106,
-0.0037989663,
-0.0035924271,
0.009643009,
0.020911245,
-0.022658363,
0.044585373,
0.0047233137,
0.021588422,
0.030662602,
0.013035669,
0.008661102,
-0.005708607,
-0.013963402,
-0.018690102,
-0.022590645,
-0.021629052,
0.038219903,
-0.021073766,
-0.00006274474,
0.0222656,
0.01986839,
-0.002722254,
0.0016362304,
0.010096718,
-0.02192701,
-0.017972292,
0.016157458,
-0.03854495,
-0.043691497,
-0.006226648,
-0.044964593,
-0.017444095,
0.03721768,
-0.001402604,
0.004801189,
0.030716775,
-0.0054580513,
-0.011234377,
0.023389714,
0.0059151463,
-0.014803102,
-0.007862031,
0.018811993,
-0.007591161,
-0.0036025848,
-0.021764487,
0.025367072,
-0.013394573,
0.010164436,
0.018717188,
-0.020152805,
-0.005925304,
-0.02398563,
0.01678046,
-0.0030439133,
-0.009433084,
0.005197338,
-0.026992299,
-0.00026875487,
-0.01795875,
0.028820679,
-0.01711905,
0.023267822,
0.003954717,
0.029958338,
0.0039750324,
0.021290464,
-0.0027087103,
0.0027594988,
0.02787263,
0.0021906695,
0.0018825537,
-0.005837271,
0.01818899,
-0.008437633,
-0.014437426,
0.006470432,
0.0003950908,
-0.0010496252,
-0.019042233,
-0.053632464,
0.0088303955,
0.0061860173,
0.0013399652,
0.008593383,
-0.0053056865,
-0.006798863,
-0.01269708,
0.011044767,
-0.008342828,
-0.033208787,
0.010360817,
-0.017931662,
-0.0061182994,
-0.017146137,
-0.018527579,
0.00015966578,
-0.020030914,
0.0066668135,
0.0053361594,
-0.0057255365,
0.0025309513,
-0.011065082,
0.009527889,
-0.012128251,
0.004689455,
-0.040359784,
0.014627036,
-0.008471492,
-0.027236084,
0.02642347,
-0.032748308,
-0.014437426,
0.0038734558,
-0.020464307,
-0.022820884,
-0.0056036445,
0.03209822,
0.025177462,
0.023904368,
0.013408116,
-0.030825123,
-0.0005235429,
-0.007035875,
-0.009527889,
-0.011660998,
-0.021805119,
0.020613287,
-0.011146343,
-0.02272608,
0.010496252,
0.009067408,
0.0031234815,
-0.025421247,
-0.021141484,
0.0018944043,
0.015439649,
-0.0073947795,
-0.024622178,
-0.004195115,
0.024500284,
-0.0041510984,
-0.005505454,
-0.02306467,
-0.0146676665,
-0.008992919,
-0.034536056,
0.008816852,
0.011004136,
0.0023362627,
-0.0029186355,
-0.0054952963,
0.006138615,
0.034211013,
0.023430346,
-0.005962549,
-0.0014068364,
0.0072932024,
0.012514242,
0.015724063,
0.02539416,
0.0019925951,
-0.03748855,
0.01105831,
0.029416595,
-0.0032809253,
0.018256707,
0.028197674,
-0.0054682093,
0.0024344535,
0.014329078,
0.024337763,
-0.014735385,
0.016062653,
0.029254071,
0.02322719,
-0.00015247076,
-0.00811936,
0.0022685449,
0.011193746,
-0.008051641,
0.006446731,
0.005498682,
-0.01864947,
-0.026613079,
0.012893462,
-0.02455446,
-0.056287,
-0.011505247,
-0.005945619,
0.0022753167,
-0.0097649,
-0.0037989663,
0.008694961,
-0.02108731,
0.008952288,
-0.022983408,
0.018365057,
-0.004564177,
0.02467635,
-0.0026105195,
-0.002326105,
0.0063553117,
0.009832619,
0.0116271395,
0.008004239,
0.027357975,
-0.01822962,
0.019475628,
0.001813143,
0.022062445,
-0.0068564233,
-0.027737195,
-0.03564663,
-0.010767124,
-0.02726317,
0.004127397,
0.016333524,
-0.010536883,
0.07730659,
0.01117343,
0.002657922,
-0.022902146,
-0.01262259,
0.018216077,
-0.022021815,
0.023403257,
-0.008363144,
-0.0012502391,
0.01327268,
-0.015642803,
0.014532231,
-0.041578703,
-0.030689688,
0.003595813,
-0.003143797,
0.011207289,
0.0045269323,
-0.017904576,
-0.011214061,
-0.009290877,
-0.0005798333,
0.0024005945,
-0.03291083,
0.005921918,
0.03919504,
0.011119256,
0.01189801,
-0.043908194,
-0.020748721,
0.01235172,
-0.046616904,
-0.012480383,
0.020071544,
-0.013990489,
-0.024486741,
-0.028576894,
0.021832205,
0.0033317138,
0.0046454384,
0.013144017,
-0.03938465,
-0.0038158956,
-0.023525149,
-0.03545702,
-0.022793798,
-0.02104668,
-0.010022229
] |
BACKGROUND Carbon nanotubes (CNT) hold great promise to create new and better products for commercial and biomedical applications, but their long-term adverse health effects are a major concern. The objective of this study was to address human lung cancer risks associated with chronic pulmonary exposure to single-walled (SW) CNT through the fundamental understanding of cellular and molecular processes leading to carcinogenesis. We hypothesized that the acquisition of cancer stem cells (CSC), a subpopulation that drive tumor initiation and progression, may contribute to CNT carcinogenesis. METHODS Non-tumorigenic human lung epithelial cells were chronically exposed to well-dispersed SW | [
-0.0015411808,
0.01283161,
0.018897222,
-0.01787968,
-0.012521061,
-0.017100003,
-0.023377052,
-0.00063266046,
-0.019994054,
0.019227592,
-0.0010737057,
0.013637715,
-0.00086309423,
0.029944828,
0.0001162493,
0.017205723,
0.027116852,
-0.017033929,
-0.013208233,
0.003363177,
-0.035997223,
0.0016964552,
-0.012032112,
-0.0010233242,
-0.0012405431,
-0.009613796,
0.041521028,
-0.046172652,
-0.005586574,
-0.032587796,
-0.0011876838,
0.0075919256,
-0.02113053,
-0.013796293,
0.0016741551,
0.018025042,
0.0024629158,
-0.0008507053,
0.016412832,
-0.040358122,
0.007506029,
-0.004311342,
0.0013247877,
0.0035019326,
-0.014760977,
0.007717467,
0.006713139,
0.0027073903,
0.012388913,
-0.010373649,
0.02113053,
0.017179292,
-0.0045062606,
0.0063761603,
-0.015950313,
-0.029046219,
-0.005652648,
0.027381148,
0.0075853183,
-0.020681225,
0.004056956,
0.023654563,
-0.0330371,
0.00865572,
-0.021659123,
0.00631339,
-0.010413294,
0.031979915,
-0.026205027,
0.0124285575,
0.018381843,
0.018923651,
0.01075688,
0.0032112063,
0.008113912,
0.006369553,
-0.042895373,
-0.0017988702,
-0.0114506595,
0.005028247,
-0.00537844,
-0.014311672,
0.007122799,
0.041415308,
0.017972182,
0.025161056,
-0.01851399,
0.0068981466,
-0.00043154712,
-0.011113681,
0.006917969,
0.022610592,
0.0025289902,
-0.0022101821,
-0.014298457,
0.022240575,
-0.011034392,
0.025161056,
-0.0035481846,
-0.038560905,
-0.0033995176,
0.007928904,
0.0025917606,
-0.014232383,
-0.019267237,
0.00236876,
0.03065843,
0.011807459,
0.028570484,
-0.020231921,
-0.013261092,
0.022623807,
-0.017100003,
-0.011747993,
0.035970796,
-0.00039851002,
0.014827051,
0.015527437,
0.015567082,
-0.03982953,
0.02228022,
0.010479368,
0.018328983,
-0.020707654,
0.037688725,
-0.008926624,
-0.031002015,
-0.01444382,
-0.0072879842,
-0.015804948,
-0.0003861211,
-0.0052694175,
0.03380356,
0.016227825,
-0.0043542897,
0.0044930456,
-0.01262678,
-0.002905613,
-0.04812845,
-0.02691863,
-0.0011562986,
0.023905646,
0.0051240544,
-0.0023753676,
0.0075721033,
0.031609897,
0.033380687,
0.026363606,
0.009930952,
0.0025818495,
0.01569923,
-0.027777594,
0.020443358,
-0.0073144143,
-0.015937097,
0.012025504,
0.0109352805,
0.013128944,
-0.00993756,
-0.0060490933,
0.013479137,
-0.01659784,
0.02514784,
0.0055535366,
0.019729756,
0.023932075,
0.007770326,
-0.004235356,
-0.0031831246,
-0.000854835,
-0.008279097,
0.009567545,
-0.026469326,
0.014338101,
-0.010188642,
-0.0046086754,
-0.020139417,
0.026178598,
-0.01777396,
-0.017285012,
-0.004499653,
0.023786712,
0.018355412,
0.010267931,
-0.019795831,
-0.03388285,
0.021659123,
0.02274274,
-0.0009399055,
-0.019967623,
-0.014272028,
0.011675311,
-0.011714956,
-0.03967095,
-0.6431927,
-0.035785787,
0.0038554296,
-0.005150484,
0.0035812217,
0.013274307,
0.017086789,
-0.008774654,
-0.043265387,
0.025213916,
-0.009858271,
0.023654563,
0.029363375,
-0.006498398,
0.0012165912,
-0.020324424,
-0.0038124814,
0.0076183556,
0.023958506,
0.0015188807,
-0.022570947,
0.015078133,
-0.0076051406,
0.0039281114,
0.014840266,
0.03145132,
0.025570717,
0.010664376,
-0.004156067,
0.028517624,
-0.025028907,
0.026667548,
0.009455218,
0.0075390665,
0.049978524,
-0.0011752949,
-0.016346758,
0.013274307,
0.019571178,
0.0017526182,
-0.005996234,
-0.0034259474,
0.0023852787,
-0.01073045,
-0.029284086,
0.017866464,
0.021685554,
-0.014615613,
0.003736496,
-0.00085648685,
0.012250157,
0.0013231359,
-0.009164492,
0.012653209,
0.0031368728,
-0.018804718,
0.02970696,
-0.02066801,
0.018461132,
0.014549539,
-0.005857478,
0.022134857,
-0.020218706,
-0.030737719,
-0.0071756584,
0.034490734,
-0.03224421,
0.014100235,
0.0021705376,
-0.017417159,
0.0074003106,
0.03879877,
0.0029650799,
-0.00089365355,
0.024196373,
0.044216856,
0.007717467,
-0.009375929,
-0.008338564,
0.006362946,
0.015408504,
0.008893588,
-0.032112062,
0.010770095,
0.013518781,
-0.011040999,
-0.016967855,
0.0094948625,
-0.0035977403,
0.020443358,
-0.02389243,
-0.002301034,
-0.003961148,
-0.03546863,
0.0027734647,
0.01987512,
0.0211041,
-0.004116423,
-0.024526743,
-0.017972182,
-0.034834318,
-0.020271566,
-0.0032062507,
-0.014668473,
0.04302752,
-0.012613565,
-0.007089762,
-0.02113053,
0.025293205,
-0.0431861,
-0.001537051,
0.0026297532,
-0.0017526182,
-0.015989957,
-0.0040635634,
-0.017655026,
0.012236943,
0.015249926,
-0.006501701,
-0.037054412,
0.020826587,
0.014866696,
-0.0054709436,
-0.00485315,
0.008061052,
0.00053520105,
0.011226007,
-0.012104793,
-0.02159305,
-0.017562523,
-0.0016039512,
-0.020747298,
0.021579834,
-0.019650467,
0.0398031,
0.0022812118,
-0.0027387757,
-0.0058409595,
-0.0036175626,
-0.012554098,
-0.039089497,
-0.0031979913,
0.007816578,
0.011080643,
0.0012025505,
0.00043443788,
-0.035257194,
0.0032392878,
-0.010710628,
-0.004694572,
-0.01687535,
-0.017073574,
-0.0078364005,
0.035442203,
0.017285012,
0.012904292,
0.014073805,
-0.03234993,
0.0050447653,
-0.026984705,
-0.0061151674,
0.009422181,
0.019610822,
-0.00642902,
-0.0034589844,
-0.002690872,
0.002096204,
0.009085203,
0.018434701,
-0.054075126,
0.0030278503,
-0.03227064,
-0.0011876838,
0.033962138,
-0.014153094,
0.0007371403,
-0.010855991,
-0.013346989,
-0.0010687502,
-0.0087085795,
-0.0020796855,
-0.0056790775,
0.009792197,
-0.0016468995,
0.0066966205,
0.029284086,
0.020707654,
-0.015738875,
-0.003465592,
0.047520567,
-0.01744359,
0.010585087,
-0.02975982,
0.002927087,
0.026878985,
-0.0062142788,
-0.0017674849,
-0.0019293667,
0.01943903,
0.01995441,
-0.011093859,
-0.0017873071,
0.024936404,
-0.0050183358,
0.025887871,
-0.012071757,
-0.0111797545,
0.015712446,
0.021143744,
-0.010525621,
0.0061581153,
0.017892893,
-0.02238594,
-0.0028808352,
-0.016095676,
0.027381148,
-0.021685554,
-0.032059204,
0.010307576,
-0.0059532854,
-0.0013503915,
-0.009508078,
0.0039908816,
-0.011708348,
-0.016584624,
0.023826357,
0.0039248075,
0.018725429,
-0.017139647,
-0.0031533912,
-0.0061812415,
0.00806766,
0.01487991,
-0.01073045,
-0.002256434,
0.025940731,
0.0113977995,
-0.013941657,
0.03967095,
0.010697413,
-0.001972315,
0.0036539033,
0.011259044,
0.010096138,
0.015302785,
0.015633157,
0.025517857,
0.023826357,
0.0010852688,
-0.004602068,
-0.019544749,
0.027962603,
-0.034200005,
0.004089993,
-0.0017344478,
-0.031081304,
0.011979253,
0.0194126,
0.033248536,
-0.00048358057,
0.029178368,
-0.008074268,
0.022557732,
-0.02317883,
-0.013981301,
0.0016667218,
0.008768046,
-0.001980574,
-0.0062142788,
0.018738644,
0.00821963,
-0.0012512802,
0.030420562,
-0.045749776,
0.025953947,
0.016333543,
0.018738644,
0.011952823,
0.007942119,
0.009131455,
-0.017033929,
-0.007472992,
0.009237173,
0.02978625,
-0.029178368,
-0.022478443,
-0.020324424,
0.012084971,
-0.009329678,
0.0005100102,
0.02397172,
0.014285242,
-0.0008556609,
0.016056031,
-0.01616175,
-0.002861013,
-0.0029700354,
-0.0039115925,
0.019016156,
-0.006571079,
0.005652648,
-0.02402458,
0.0020416928,
0.005368529,
0.018447917,
0.016452476,
0.0052727214,
-0.0114506595,
-0.0015130992,
-0.02263702,
-0.0038124814,
-0.024051009,
0.0014057286,
-0.007882652,
-0.008728402,
-0.002576894,
0.013743434,
-0.0013090951,
0.030552711,
-0.018857578,
0.00047366944,
-0.036208663,
-0.026297532,
0.00052322506,
0.027513297,
0.013247877,
-0.015395289,
-0.0023175527,
0.006448842,
-0.03216492,
-0.0035580958,
-0.032059204,
0.015276356,
-0.01201229,
0.007486207,
-0.014258812,
0.009217351,
0.008331956,
0.014787407,
0.025002478,
-0.0129175065,
-0.010591694,
-0.018936867,
-0.014179524,
0.0062043676,
-0.005639433,
0.05534375,
0.048339885,
0.0066867094,
0.0057055075,
-0.003235984,
0.024262447,
-0.00021267633,
-0.00494235,
0.0036175626,
0.014866696,
0.002745383,
0.02730186,
-0.008378209,
-0.0053454028,
0.0007685255,
0.015871024,
0.0046978756,
0.0051306617,
-0.0133800255,
-0.0060523967,
0.014192739,
0.00009807889,
0.0059863226,
-0.023244904,
0.027460437,
-0.005011728,
-0.0030674948,
-0.011622452,
0.041071724,
-0.031609897,
-0.009924345,
-0.029046219,
0.012719284,
-0.020139417,
0.006584294,
-0.015910668,
-0.000103963626,
-0.011648881,
-0.0028841388,
-0.019584393,
0.02164591,
-0.0011348244,
-0.00832535,
-0.010955103,
0.00011480392,
0.00011924328,
-0.009666655,
0.003338399,
0.013849152,
-0.015501007,
-0.029654102,
0.032402787,
0.021579834,
-0.0067990352,
0.026350392,
-0.0054081734,
-0.026931845,
0.02402458,
-0.015038488,
-0.0070501175,
-0.022399154,
-0.015593511,
0.009818627,
-0.013783079,
0.01262678,
-0.01692821,
-0.025319634,
0.013254485,
0.0106908055,
-0.022227362,
-0.0052925437,
0.010492583,
-0.002472827,
0.003610955,
0.010367042,
0.02650897,
-0.0044038454,
-0.012342661,
-0.01787968,
-0.023826357,
0.0068122502,
-0.0039049853,
0.008074268,
-0.011477089,
0.00050340284,
0.00993756,
-0.0067858207,
-0.0017641812,
0.0054742475,
-0.018223265,
0.013849152,
0.004056956,
-0.0116951335,
0.015210281,
-0.0023159008,
0.011523341,
-0.008470712,
-0.008662328,
0.011325118,
-0.0047474313,
0.02353563,
-0.01198586,
-0.015857808,
0.0011455615,
-0.008318742,
-0.02607288,
-0.019346526,
-0.0031401764,
-0.0054841586,
0.010664376,
0.00001598944,
-0.030156266,
0.0015362252,
-0.012481417,
-0.01528957,
-0.014457035,
-0.011866926,
-0.01131851,
-0.01782682,
0.017985398,
0.008305527,
-0.0052132546,
0.017403945,
-0.033274967,
-0.020654796,
0.025848228,
-0.0023984935,
0.001412336,
-0.01651855,
-0.007089762,
-0.027856883,
-0.015844593,
-0.005163699,
-0.02978625,
-0.015672801,
-0.012468202,
0.04736199,
0.0049126167,
0.040120255,
-0.018421488,
0.02432852,
0.007737289,
-0.00040697577,
0.0037100664,
-0.005639433,
0.010162212,
-0.0071822656,
0.027513297,
0.008292312,
-0.0067626946,
0.0062473156,
-0.0053586178,
0.004872972,
0.025702864,
-0.0051934323,
-0.020403713,
0.007076547,
-0.0381116,
-0.041151013,
-0.004103208,
-0.022042353,
-0.006296871,
-0.031900626,
-0.008827513,
0.020535862,
0.019888334,
-0.007994979,
-0.0019855297,
0.020734085,
-0.0017080181,
0.00060292706,
-0.013518781,
0.01528957,
-0.012692854,
-0.02571608,
-0.011311904,
-0.02069444,
0.014192739,
0.0036274737,
-0.017562523,
0.0140870195,
-0.012580528,
-0.018064687,
-0.011933001,
-0.013459315,
-0.025953947,
-0.012223727,
-0.030103406,
-0.020218706,
-0.018289339,
-0.010869206,
-0.03224421,
0.0045723347,
0.009375929,
-0.008417853,
0.009230566,
-0.013954871,
-0.0056163073,
0.015857808,
-0.0030146355,
0.01096171,
-0.024857115,
0.029336946,
0.01341967,
-0.02814761,
-0.018011827,
-0.0029320426,
0.0018467739,
0.012653209,
0.03071129,
0.012924114,
-0.02820047,
-0.00012791553,
-0.008166771,
0.026495755,
-0.006174634,
-0.016782846,
0.00973273,
0.0005426344,
0.00476395,
-0.017707886,
-0.028411906,
-0.014919555,
0.023363838,
0.0005174436,
-0.016967855,
-0.008034623,
-0.027116852,
-0.00862929,
0.016174965,
-0.0017707886,
0.022121642,
0.0014536324,
-0.0059070336,
-0.025517857,
-0.012355875,
-0.028544055,
0.007849615,
0.0052132546,
0.034992896,
0.0009845056,
-0.008120519,
0.024473885,
-0.013003402,
-0.011609237,
0.013095907,
-0.0014040768,
0.04545905,
-0.0032888434,
0.00044723976,
-0.0048135053,
-0.004820113,
0.033327825,
-0.0077967555,
-0.0057616704,
-0.018580066,
-0.040040966,
-0.015236711,
0.018672569,
0.030764148,
-0.003044369,
-0.022491658,
-0.0033086657,
0.0033697842,
-0.035019327,
-0.020020483,
0.009772374,
-0.031874195,
-0.008556609,
0.016505336,
-0.00066156796,
0.0265354,
0.007294592,
-0.0065545607,
-0.019174734,
0.043582544,
-0.016505336,
0.018659355,
0.017615382,
0.023733852,
-0.0029518649,
0.018553635,
0.005216558,
-0.031213453,
-0.017351085,
-0.01298358,
-0.034279294,
-0.0333014,
-0.007644785,
0.017681457,
0.0032277247,
-0.012170868,
0.041124582,
0.011146718,
0.010902244,
-0.011331726,
-0.012488024,
0.0017460107,
-0.02471175,
0.000073404306,
0.0044963495,
-0.010400079,
-0.001698107,
-0.02164591,
-0.016056031,
-0.006356338,
-0.0054775514,
-0.01572566,
-0.006620635,
-0.0015486141,
-0.005606396,
-0.016201394,
-0.015857808,
-0.018315768,
-0.019729756,
-0.00013359377,
-0.019227592,
-0.01403416,
-0.005242988,
-0.025927516,
0.0047672535,
0.001401599,
-0.03819089,
-0.0055502327,
0.0041758893,
-0.009428789,
-0.032482076,
-0.0151177775,
-0.002267997,
0.02683934,
0.020786943,
-0.005117447,
-0.023720639,
-0.0017790479,
-0.051564306,
-0.020919092,
-0.010135783,
0.021381611,
0.0016113846,
0.0052661137,
-0.014047375,
0.013743434,
-0.00016281096,
0.0015114474,
-0.0067726057,
-0.027830454,
0.033671413,
-0.016280683,
0.04379398,
0.022108428,
-0.046093363,
0.017271796,
0.043926127,
0.020469788,
-0.021553405,
0.019254021,
0.0062374044,
0.012785358,
-0.0058343518,
0.021011597,
-0.010380257,
0.00042142952,
-0.01938617,
-0.010380257,
0.022214146,
0.01365093,
-0.019095445,
0.009256995,
0.007856223,
0.002301034,
0.0041990154,
0.007948726,
0.016241038,
-0.039433084,
0.0097129075,
-0.001470151,
-0.01119297,
0.010809739,
0.03129274,
0.026191814,
0.0021457598,
-0.013346989,
-0.013479137,
-0.005523803,
0.002642968,
-0.01695464,
0.01626747,
0.004179193,
-0.007122799,
0.032561366,
0.002793287,
-0.014562754,
0.00072888104,
-0.009422181,
-0.008754832,
-0.015104562,
0.03052628,
-0.000831296,
-0.017060358,
-0.020112988,
-0.0005000991,
-0.01682249,
0.002051604,
-0.016637484,
0.013459315,
-0.056718096,
0.02525356,
0.0030295022,
-0.00028391258,
-0.01303644,
-0.0005331362,
0.0039347187,
-0.0003055932,
0.0022646931,
0.18775645,
-0.0057154186,
0.011741386,
0.016386403,
0.0061713303,
-0.021857345,
0.0033896065,
-0.0011645578,
-0.026495755,
0.015012058,
0.021408042,
0.0045392974,
0.0028808352,
-0.0041428525,
0.010069708,
0.024249231,
-0.030843437,
-0.0077306814,
-0.009204136,
-0.00845089,
0.0063959826,
0.00049390463,
0.022729525,
0.0024959529,
0.008556609,
-0.010598302,
-0.01813076,
-0.02732829,
0.023099542,
0.011794245,
-0.018870791,
0.006984043,
-0.004321253,
-0.0080280155,
0.009138062,
-0.0014907991,
0.020522647,
0.0012479764,
-0.005160395,
0.009752552,
0.024447454,
0.01575209,
-0.019399386,
-0.0076844296,
-0.00087465724,
0.030869868,
-0.007988371,
-0.00993756,
0.014364531,
0.0047110906,
-0.03964452,
0.023879217,
0.036076512,
0.02397172,
-0.015844593,
-0.0048828833,
0.017285012,
0.0053982623,
-0.0017212329,
0.03710727,
-0.031609897,
-0.0073672733,
0.012897684,
0.037662294,
-0.0011984209,
-0.0014420694,
-0.029125508,
0.01303644,
0.011311904,
-0.010585087,
-0.0116951335,
-0.0145759685,
-0.022874888,
0.008622684,
-0.027063994,
-0.004592157,
0.025042122,
0.015976742,
0.020152632,
0.01257392,
0.013730219,
-0.03451716,
-0.028861212,
0.007895867,
-0.0042188377,
-0.028570484,
0.019637253,
0.015276356,
0.0031765173,
-0.0051934323,
-0.0030790577,
0.018196834,
-0.0100366715,
0.007955334,
0.018765073,
0.0042320527,
0.0030146355,
-0.02020549,
0.010723843,
0.004460009,
-0.039115928,
0.057986718,
-0.002553768,
0.009045558,
-0.0025372494,
0.03380356,
-0.0061581153,
0.0038884669,
-0.00056947704,
0.0034358585,
-0.0021375003,
-0.024989262,
0.0042089266,
-0.0150913475,
-0.0073672733,
0.024724966,
0.008140341,
-0.029442664,
0.028332617,
-0.022491658,
0.011959431,
-0.023482772,
0.010677591,
0.015686015,
-0.011120288,
0.0018649444,
-0.018527206,
0.0002113342,
0.000109332155,
-0.031187022,
-0.00073548843,
-0.017998612,
-0.027619015,
-0.008721795,
0.010459546,
0.005381744,
-0.0020003964,
-0.016227825,
0.012976973,
0.0069708284,
-0.0054081734,
-0.017047144,
0.01060491,
0.009600582,
0.0043575936,
-0.005890515,
0.0097063,
-0.00022960785,
0.009270211,
-0.018540422,
-0.007717467,
-0.01769467,
0.005854174,
-0.014655258,
0.0032310286,
0.003544881,
-0.018223265,
-0.028464766,
-0.012554098,
0.010836169,
-0.0038422148,
-0.017972182,
0.0166507,
0.0053156693,
-0.009917738,
-0.00742674,
-0.16587268,
0.019042585,
0.030367702,
-0.0005608048,
0.007843007,
0.01626747,
0.009508078,
-0.0030559318,
0.015857808,
-0.0015700882,
0.043265387,
-0.016941424,
-0.028279759,
-0.017813604,
0.026773266,
-0.016386403,
-0.007030295,
0.036869403,
0.028438337,
-0.0017261885,
0.01101457,
-0.02691863,
0.0047110906,
0.0026627902,
-0.0055436254,
0.008312134,
0.00211933,
-0.0040602596,
-0.0190558,
-0.007142621,
0.0068320725,
-0.01298358,
0.029284086,
0.00075737556,
0.023680994,
0.021698767,
-0.016293898,
-0.030473422,
0.0053619216,
0.0026297532,
0.023654563,
0.028517624,
0.004872972,
-0.02402458,
-0.01370379,
0.018315768,
-0.009217351,
-0.0010745317,
0.023337407,
-0.01583138,
0.041706037,
-0.008285705,
0.0145759685,
0.027619015,
-0.018989725,
0.008728402,
0.014708118,
-0.0019425815,
0.008920018,
-0.006369553,
-0.0006677624,
-0.027169712,
-0.005983019,
-0.015170637,
-0.009653441,
-0.04371469,
-0.0016708514,
-0.007235125,
-0.026416466,
0.025042122,
-0.030156266,
0.006148204,
-0.0032392878,
-0.018064687,
0.023086326,
0.008834121,
0.009356107,
0.0062374044,
-0.018461132,
-0.0055204993,
-0.006924576,
0.013941657,
0.0020367373,
-0.005252899,
-0.01995441,
0.0024232713,
0.001390036,
0.0063431235,
-0.0031021838,
-0.007406918,
0.012388913,
-0.0070236875,
-0.008166771,
-0.01621461,
0.013413063,
0.025597146,
0.020535862,
-0.022835243,
-0.0076183556,
-0.011477089,
0.015302785,
-0.025729295,
-0.021751627,
0.011437444,
0.03858733,
0.01654498,
-0.01347253,
0.0007994978,
0.045934785,
-0.005048069,
-0.013128944,
0.0035514883,
0.011675311,
0.024645677,
0.0075985333,
0.016399616,
-0.014232383,
0.0025686347,
-0.01347253,
-0.037398,
0.042525355,
0.0017146255,
-0.02981268,
0.030922726,
0.0055634477,
0.0032194655,
-0.12231656,
-0.022927748,
0.01239552,
0.04294823,
-0.019359741,
0.018474346,
-0.014258812,
0.019452244,
0.0048597576,
0.024751395,
0.016029602,
-0.029971257,
-0.0055204993,
0.01943903,
0.013459315,
-0.018540422,
0.027751165,
-0.0111797545,
-0.027671875,
0.01782682,
0.011146718,
-0.020231921,
0.0028395387,
-0.03568007,
0.0064884867,
0.006666887,
-0.042023193,
0.035230763,
0.027883314,
0.022808814,
-0.016307114,
0.014166309,
0.010538835,
-0.0194126,
-0.0131355515,
-0.0052495953,
-0.0017608774,
-0.035997223,
0.035310052,
-0.019016156,
-0.0018698999,
0.027539726,
0.021817701,
0.006931184,
0.009276818,
-0.022755954,
-0.033539265,
0.024553172,
0.008199808,
-0.025755724,
0.0016758069,
-0.012666425,
0.00020039067,
-0.0031137466,
0.009342892,
-0.02443424,
0.010882421,
0.03393571,
-0.004235356,
0.004740824,
-0.0054048696,
0.0014891473,
-0.006452146,
0.019293666,
0.025623575,
-0.02031121,
-0.00950147,
-0.010684199,
0.018223265,
-0.02471175,
-0.006584294,
-0.017060358,
-0.017588953,
0.0028081536,
-0.021394826,
-0.013254485,
0.005183521,
-0.0035382735,
-0.02353563,
-0.015276356,
0.005183521,
-0.016426047,
0.014430606,
-0.039433084,
0.004397238,
-0.004294823,
-0.0036043476,
0.010505798,
-0.004321253,
-0.011866926,
0.009395751,
0.01657141,
-0.01367736,
-0.017100003,
0.020099772,
0.007856223,
-0.0136245005,
0.012494631,
0.028359048,
0.016716773,
-0.026627904,
-0.01621461,
-0.06448842,
0.007565496,
0.003746407,
0.0009291685,
-0.0150649175,
0.0033648286,
0.03562721,
-0.008781262,
-0.0095212925,
0.01695464,
-0.008179986,
0.029363375,
-0.01370379,
0.0069906507,
-0.028279759,
-0.015527437,
0.0021804487,
0.018910436,
0.015421718,
0.01938617,
0.030632,
-0.0097393375,
0.0010233242,
0.020020483,
-0.012732498,
0.0053520105,
-0.0033714361,
0.012051934,
-0.007955334,
0.0013974693,
0.041917473,
-0.0145759685,
-0.0032277247,
-0.015976742,
0.011311904,
-0.009316462,
0.0052727214,
0.010684199,
0.0017972182,
0.024592817,
-0.0078099705,
-0.015025273,
-0.012408735,
0.024830684,
-0.004126334,
0.00742674,
-0.017166078,
0.010519013,
0.028596913,
0.015672801,
0.02566322,
0.012283194,
0.011430837,
-0.034015,
-0.022267006,
0.011919786,
0.010505798,
-0.006072219,
-0.016637484,
-0.012521061,
0.036552247,
0.037001554,
0.021434471,
0.023694208,
0.0015164029,
-0.01902937,
-0.030103406,
-0.030394133,
-0.005596485,
-0.012712676,
-0.008424461,
-0.0068651093,
0.020324424,
-0.021262677,
-0.007076547,
0.0020086558,
-0.028517624,
0.000047981226,
-0.0036869405,
0.007340844,
-0.006574383,
-0.006448842,
-0.048577752,
-0.004730913,
0.015448148,
0.01643926,
-0.018011827,
0.011999075,
0.013783079,
-0.0087614395,
-0.0055337143,
0.012362483,
-0.00464832,
-0.016796062,
0.011067429,
0.015857808,
-0.010393471,
0.013221447,
-0.000832122,
0.02069444,
0.011417622,
0.012653209,
-0.0016444217,
-0.00232416,
-0.018289339,
0.017271796,
-0.016888566,
-0.016782846,
-0.0015395288,
0.013690574,
0.027486868,
-0.0019376259,
-0.00476395,
-0.0012694506,
-0.02031121,
0.0145759685,
-0.011404407,
0.010419901,
-0.008635898,
0.036684398,
0.020496218,
0.007737289,
0.020549078,
0.004043741,
0.0028775316,
0.006845287,
0.012706069,
-0.013994516,
0.037054412,
-0.012521061,
0.012124616,
-0.009805411,
-0.043371107,
-0.006917969,
-0.0071624434,
-0.026191814,
0.02113053,
0.0057814927,
-0.030261984,
0.072417326,
0.028491195,
-0.028279759,
0.011444052,
-0.010776702,
0.01078331,
0.029416235,
0.004806898,
0.010968317,
-0.02702435,
-0.00016890217,
-0.026218243,
-0.000136691,
-0.05460372,
-0.029257657,
0.032561366,
0.0028345832,
0.016729988,
-0.00039148965,
-0.005844263,
0.02479104,
-0.010248109,
0.009256995,
0.027830454,
-0.011979253,
0.001025802,
0.03827018,
0.017998612,
0.0028890944,
-0.021262677,
-0.0090323435,
0.014787407,
-0.013994516,
-0.0135980705,
-0.0012669729,
0.009105025,
-0.0003278932,
-0.034173578,
0.018672569,
0.010697413,
-0.010789917,
0.04881562,
-0.017681457,
-0.021275893,
-0.022914533,
-0.013862368,
0.006141597,
-0.016941424,
-0.008550001
] |
We compared two genetically highly defined transgenic systems to identify parameters affecting reprogramming of somatic cells to a pluripotent state. Our results demonstrate that the level and stoichiometry of reprogramming factors during the reprogramming process strongly influence the resulting pluripotency of iPS cells. High expression of Oct4 and Klf4 combined with lower expression of c-Myc and Sox2 produced iPS cells that efficiently generated "all-iPSC mice" by tetraploid (4n) complementation, maintained normal imprinting at the Dlk1-Dio3 locus, and did not create mice with tumors. Loss of imprint | [
-0.026689677,
0.0066458755,
0.002865059,
-0.023862774,
-0.031507354,
0.008075916,
-0.020796979,
0.0028119718,
-0.033020347,
-0.010053421,
0.01410797,
0.0050930697,
-0.00026274103,
-0.002284416,
-0.020398824,
-0.000024508843,
0.034533337,
-0.0027622024,
0.0073990524,
0.01389562,
-0.027685065,
-0.0007038224,
0.0048873564,
-0.018554037,
-0.0061581354,
0.020040484,
0.017810814,
-0.032648735,
-0.010312222,
-0.021473842,
0.021473842,
0.018195696,
-0.024114938,
0.009263746,
-0.024765259,
-0.013006406,
-0.009688445,
-0.013371382,
0.007903382,
-0.01986795,
0.02123495,
0.02829557,
-0.010365309,
0.01116162,
-0.011871664,
0.0038786961,
-0.016815426,
0.0016166765,
-0.00040105853,
0.016231464,
0.011612863,
0.008022829,
-0.014492853,
-0.00047695686,
-0.02383623,
-0.021062415,
0.0039649634,
0.014492853,
0.0086266985,
-0.012614887,
-0.0064633875,
-0.004310031,
-0.012157008,
0.03325924,
-0.004917218,
0.011407149,
-0.009721626,
0.0061448636,
0.02505724,
-0.012940047,
0.031799335,
0.01893892,
-0.006533065,
-0.0064169364,
0.011858392,
-0.0027422947,
-0.007803844,
-0.0017518833,
-0.009389829,
0.015461697,
0.013378018,
-0.023238998,
-0.0016763997,
0.012681246,
-0.0017253396,
0.0032084682,
0.012555163,
0.0155546,
0.008845683,
0.0056803487,
0.014015066,
0.033365414,
0.034400616,
0.024393648,
-0.013470921,
0.005521087,
-0.00014474604,
0.031427726,
-0.011805304,
-0.02635788,
-0.018514222,
0.00390524,
-0.017014503,
-0.023066463,
-0.03809019,
0.009369921,
0.02297356,
-0.00023516048,
0.02585355,
0.006543019,
-0.024075124,
0.030100541,
-0.00043548236,
-0.052158345,
0.022416143,
-0.007551679,
-0.0012649726,
0.0061349096,
-0.024380377,
0.008659878,
0.033657394,
0.016576532,
0.0043598004,
-0.018872561,
0.007903382,
0.03140118,
-0.004091046,
0.012137101,
-0.0351173,
-0.010584295,
0.025574842,
-0.008633334,
0.009263746,
0.025654472,
-0.014718474,
0.0041043176,
-0.0014615618,
-0.011141713,
-0.013616911,
-0.019217629,
-0.012389266,
0.015315707,
0.005232424,
-0.0063306694,
-0.0037127982,
-0.0007871862,
0.020067027,
-0.009967154,
0.02289393,
-0.0057467083,
-0.009383193,
-0.00763131,
0.027021473,
0.009714989,
0.016603075,
0.020823522,
0.031056114,
0.030896852,
-0.025229774,
0.004558878,
-0.011188163,
-0.009296926,
-0.009197387,
0.0223896,
0.0066558295,
0.031162288,
0.015674047,
0.016669435,
0.0063074436,
-0.014519396,
-0.0153024355,
0.014280504,
-0.04031986,
0.024672357,
-0.00889877,
0.0044991546,
-0.0043797083,
-0.0060386886,
-0.014798105,
-0.035515454,
-0.002962939,
0.02938386,
0.013961979,
0.014439765,
-0.018925648,
-0.009150936,
0.007312786,
-0.024260929,
-0.0036696647,
-0.009184116,
0.0077507566,
0.013723086,
-0.011838485,
-0.0025150143,
-0.6328015,
-0.03363085,
0.03620559,
-0.026848938,
0.022920473,
0.042655703,
0.010458212,
-0.015594415,
-0.013152396,
0.025282862,
-0.013776173,
0.0030143673,
0.024287473,
-0.030286346,
-0.013086038,
-0.046212558,
0.010464848,
-0.005338599,
0.014134513,
0.0134178335,
-0.027339997,
-0.0086266985,
-0.008659878,
0.033710483,
0.0046020118,
0.0109559065,
0.035037667,
-0.016974688,
-0.039337743,
0.024380377,
-0.011679222,
0.01454594,
-0.015010455,
-0.006241084,
0.04658417,
0.010969179,
-0.020478453,
0.02232324,
0.02549521,
0.060466517,
-0.019629056,
-0.013510737,
0.021128774,
0.032569103,
-0.012568436,
0.020053755,
0.0023590701,
0.018049708,
-0.014373406,
0.017890444,
0.009568999,
0.0096088145,
-0.02391586,
0.0020803614,
0.011294339,
-0.012143737,
0.02095624,
-0.007837024,
0.024592726,
-0.01706759,
0.0025000835,
0.0057168463,
-0.031932056,
-0.008182092,
-0.0032864402,
0.011234615,
0.007624674,
-0.0009472778,
0.0045422884,
-0.023053192,
0.018447863,
0.023106279,
-0.0101861395,
0.019124726,
-0.008633334,
0.02988819,
-0.005079798,
0.00030774088,
0.016934872,
-0.010192775,
-0.0029015567,
-0.02095624,
-0.0060453247,
0.0033975919,
0.021805638,
0.015036998,
-0.008082553,
0.033179607,
-0.004164041,
0.0061415453,
0.03490495,
0.00032744126,
-0.0074255965,
-0.037187703,
-0.038992677,
0.0017535423,
-0.015355523,
0.009024854,
-0.0017170447,
-0.026331337,
-0.02376987,
0.007863567,
0.01641727,
0.011646043,
0.018142609,
0.016032387,
-0.034692597,
0.0070938,
0.029251143,
-0.018593851,
0.0038421985,
-0.0020438638,
0.0010493051,
-0.008540431,
0.008162184,
-0.019562697,
0.016297823,
0.00053875387,
-0.01785063,
-0.018540764,
0.027393084,
-0.02434056,
-0.007458776,
0.027950501,
-0.006095094,
0.014784833,
0.0025913273,
0.000052568943,
0.006032053,
-0.008686421,
-0.010604203,
-0.0143601345,
0.029065337,
-0.033604305,
0.008022829,
-0.012575071,
0.017863901,
-0.0063638487,
0.031507354,
-0.0338432,
-0.026437512,
-0.0071667954,
-0.0047480017,
-0.013855805,
-0.016934872,
-0.014784833,
-0.000030120864,
-0.009708353,
0.024128212,
-0.011174892,
0.013908892,
-0.010809916,
0.0026444148,
-0.0019675507,
0.023876047,
-0.01086964,
-0.009661902,
-0.020067027,
0.010073329,
-0.02988819,
-0.008374533,
0.027631978,
-0.010690469,
-0.008294902,
0.00045704911,
-0.016948143,
-0.007173431,
0.0014242347,
-0.023663696,
-0.014731746,
0.009568999,
-0.0043763905,
-0.02030592,
-0.00023018353,
-0.007850295,
0.0027290229,
0.00372607,
-0.012409173,
0.0038388807,
-0.005511133,
-0.0015528057,
-0.018872561,
-0.025508482,
-0.00540164,
0.04138161,
0.009270382,
0.024818346,
0.010385217,
-0.0051295673,
0.02757889,
-0.0090314895,
0.00020052926,
0.00009041443,
0.016722523,
0.020491727,
-0.00675205,
0.004721458,
0.008985038,
-0.0043598004,
0.021553474,
0.018262057,
-0.021062415,
-0.0016614689,
-0.02484489,
0.013364746,
-0.026795851,
0.011500052,
-0.028799899,
-0.012230003,
0.017465746,
-0.00054538983,
0.00658947,
-0.00857361,
-0.022256881,
0.01285378,
-0.009131028,
-0.005013439,
-0.011785396,
-0.008162184,
-0.008115732,
-0.0023740008,
-0.0034208177,
0.017492289,
0.0009199046,
-0.000029317294,
-0.0029347364,
0.0049139,
0.00388865,
0.022867385,
0.0045157447,
0.0073260576,
-0.006705599,
0.009774713,
-0.0032831223,
0.036232132,
0.012940047,
0.015820038,
-0.013550552,
0.05162747,
0.00069552753,
0.015647503,
0.03270182,
0.018885832,
-0.0031835835,
-0.01656326,
-0.009210659,
0.030976482,
0.007704305,
-0.016284551,
-0.00045082794,
-0.025946453,
0.020213017,
-0.025588114,
0.007903382,
0.013988523,
-0.021580016,
-0.01015296,
0.019310532,
0.013961979,
0.024314016,
-0.00075193285,
-0.030206716,
0.0028385154,
-0.023358444,
-0.0010194435,
0.007458776,
0.004645145,
-0.0124556245,
-0.006012145,
-0.005988919,
-0.025083784,
0.015780222,
0.017465746,
-0.012727697,
-0.0033975919,
0.005677031,
0.0022927108,
0.014824649,
0.019283988,
-0.0056272615,
-0.008414349,
-0.02376987,
0.025880095,
0.02053154,
0.007113708,
0.01202429,
-0.04031986,
-0.032436386,
0.0056040357,
0.0019410071,
0.010179504,
-0.008772688,
0.018766386,
0.010159596,
-0.0013329907,
-0.02232324,
0.01234945,
-0.014426494,
0.02728691,
-0.020571357,
0.028852988,
-0.007843659,
-0.015806764,
-0.00043548236,
0.03867415,
0.00439298,
-0.01015296,
-0.020345736,
-0.0050200745,
-0.011035537,
0.0101463245,
-0.029198054,
-0.013855805,
-0.0043531647,
-0.007193339,
-0.015236076,
-0.00014370917,
0.0058097495,
0.01807625,
0.005892698,
-0.012920139,
-0.024008764,
0.0010426692,
0.0075914944,
0.016576532,
0.029755473,
-0.0041076355,
0.018965464,
-0.010617475,
-0.0016158469,
-0.010637382,
-0.016934872,
0.021726007,
-0.015833309,
0.012302998,
0.008693057,
0.007518499,
-0.011798669,
-0.003991507,
0.01576695,
-0.0026842302,
-0.032117862,
-0.029543122,
-0.004830951,
-0.01627128,
0.010418397,
0.017863901,
0.020292649,
0.0055575846,
0.004814361,
0.01404161,
0.03246293,
-0.032569103,
0.0010841436,
-0.027339997,
0.025933182,
0.012973227,
0.0097813485,
-0.0043631187,
-0.041169256,
0.020558085,
0.002286075,
-0.020120114,
0.028667182,
0.019350348,
0.023530979,
0.006921266,
-0.003147086,
0.0056903027,
-0.0073990524,
-0.015833309,
0.006616014,
-0.008825776,
-0.03556854,
0.014638843,
-0.023172637,
-0.008129004,
-0.0005333622,
0.0021467207,
0.0024154754,
-0.009442916,
-0.028906075,
-0.005348553,
-0.0036895724,
-0.0050333464,
-0.022004716,
0.018686755,
0.004459339,
-0.015488241,
-0.022641765,
-0.0009124392,
-0.01785063,
-0.028030133,
-0.01469193,
0.024937794,
-0.024858162,
-0.04650454,
0.0018862607,
0.01620492,
0.027472716,
0.00946946,
-0.018474406,
-0.0021666284,
0.014944095,
0.004210492,
-0.027658522,
0.021420754,
-0.02980856,
0.028030133,
0.012064106,
-0.016855242,
-0.015528057,
-0.0002778792,
0.0028617412,
0.019854678,
-0.005607354,
-0.013026314,
-0.0053551886,
-0.008580247,
0.014652115,
0.012216732,
0.021686193,
-0.0004161967,
-0.006025417,
-0.0073526013,
-0.025216501,
-0.007903382,
-0.028109765,
-0.024924522,
-0.015368794,
-0.0060055093,
-0.00675205,
-0.033391956,
-0.00881914,
0.0329938,
-0.01700123,
0.015581144,
-0.0018481042,
0.034533337,
0.03174625,
-0.028614094,
0.008162184,
-0.0030525238,
-0.0016100404,
-0.01576695,
-0.03140118,
0.030949939,
0.01591294,
-0.021367667,
-0.0010061716,
0.013557188,
-0.018341687,
-0.030684501,
-0.0030010955,
-0.021248221,
0.014917552,
-0.01700123,
-0.0070805284,
-0.009953883,
-0.0057102107,
-0.009522548,
0.025176687,
0.022920473,
-0.020226289,
-0.009701718,
0.005511133,
-0.0012732674,
-0.024433464,
0.025229774,
-0.031772792,
-0.0011040515,
0.02549521,
0.019907765,
0.0021301308,
0.0036763006,
-0.0036829365,
-0.02901225,
-0.024632541,
-0.0055476306,
-0.040585298,
0.0059524216,
-0.02938386,
0.058289934,
0.035488907,
0.041461237,
0.029224599,
0.0132253915,
0.013815989,
-0.009283654,
0.0071535236,
0.015488241,
0.034427162,
-0.02116859,
0.01807625,
-0.0016299483,
0.000613408,
0.015368794,
-0.019934308,
0.008925315,
0.029463492,
-0.008885499,
-0.014891008,
0.024075124,
-0.021380939,
-0.020863337,
-0.0040246863,
0.004917218,
0.0025249682,
-0.016603075,
0.0147450175,
-0.0016332662,
-0.0010791668,
0.00070465193,
0.0015387043,
0.037479684,
-0.025933182,
0.016165106,
0.0060420064,
0.002544876,
-0.019775046,
0.0053750966,
-0.0031951962,
0.0018464451,
0.012084013,
-0.008407713,
0.022190522,
0.010119781,
-0.006685691,
0.0031056113,
0.029782016,
-0.027631978,
-0.008208635,
-0.0141876,
-0.016735794,
-0.017293211,
-0.007717577,
-0.0052058804,
-0.01793026,
-0.010843096,
0.006652511,
-0.04552242,
0.020372279,
-0.0062244944,
0.0003519112,
0.019934308,
0.004064502,
0.028746812,
0.0004790306,
0.006403664,
0.030631414,
0.010405125,
-0.024924522,
-0.022509046,
-0.0048807203,
0.009568999,
0.03851489,
0.033604305,
0.0010343742,
-0.03867415,
0.0065397006,
-0.014015066,
-0.022256881,
-0.035833977,
-0.009071304,
-0.016987959,
-0.004910582,
-0.004071138,
0.0033610943,
-0.028189395,
0.0017916989,
-0.0094163725,
0.020611173,
-0.00036808627,
-0.002364047,
-0.018832745,
0.013125853,
-0.00034506794,
-0.004124225,
0.02440692,
-0.01339129,
0.00013873224,
-0.02440692,
-0.0077972077,
0.0044327956,
-0.000005667103,
0.025362492,
-0.023849502,
0.003918512,
-0.00096801505,
-0.00759813,
-0.0056936205,
0.00013354792,
-0.00039172676,
0.041275434,
-0.018421318,
0.0026477326,
0.002951326,
0.006848271,
0.00072041224,
-0.027764697,
-0.017266668,
-0.004167359,
-0.029835103,
0.009476096,
0.03248947,
-0.0032615555,
0.0169216,
-0.0047015506,
-0.015209532,
-0.0038621065,
-0.028348656,
-0.0223896,
0.0016506854,
-0.040638383,
0.01184512,
0.0022927108,
0.029118424,
0.014612299,
0.012448989,
0.012329542,
0.0035767618,
0.02657023,
-0.031852424,
0.023862774,
0.0021799002,
0.00932347,
-0.025959725,
0.0034241355,
-0.029649299,
-0.020836795,
0.014293775,
-0.027207278,
-0.038063645,
-0.007823751,
0.005411594,
0.012223368,
0.012084013,
-0.006174725,
0.008407713,
0.007445504,
0.009787984,
-0.021686193,
0.00043174965,
-0.0047247764,
-0.023212453,
0.011446965,
0.008228543,
-0.017412659,
0.00052755576,
-0.024101667,
0.0025730785,
0.01771791,
-0.017625008,
-0.0031188831,
0.0065463367,
-0.0092438385,
-0.023026649,
0.0010451577,
-0.01885929,
-0.015966028,
-0.018381502,
0.004137497,
0.0076711252,
-0.012541892,
-0.028799899,
0.009396465,
0.0013412856,
0.0056305793,
-0.018952193,
-0.0058197035,
-0.0056405333,
-0.028932618,
-0.030180171,
0.009562363,
-0.01706759,
0.040293317,
0.01936362,
-0.0023839548,
-0.03039252,
-0.0041706767,
-0.053910226,
-0.04082419,
-0.01714722,
0.0057865237,
0.0035037666,
0.0068748146,
-0.014917552,
-0.029330773,
-0.019058367,
0.01021932,
-0.005421548,
-0.030339433,
-0.0028451513,
0.008971766,
0.026689677,
0.0113208825,
-0.02664986,
-0.016430542,
0.027738152,
-0.007226519,
0.004286805,
0.033869743,
-0.008951859,
0.05542322,
-0.009038125,
0.04427487,
0.010929363,
0.013815989,
0.032940716,
-0.030047454,
-0.0040346403,
0.021845454,
-0.00081497413,
0.0024005447,
-0.007173431,
0.0007336841,
0.0047944533,
-0.008062645,
0.0028567642,
-0.01858058,
0.0054713176,
-0.009429645,
0.0169216,
-0.0060552787,
0.0063771205,
-0.0057102107,
0.014930824,
0.0069809896,
-0.0076114023,
0.016443813,
0.0031437678,
0.011884935,
0.025866823,
-0.0029380543,
-0.019403435,
0.008858955,
-0.004137497,
-0.025243046,
-0.012913504,
-0.0018033118,
-0.018408047,
-0.024592726,
0.011619499,
0.0053684604,
-0.013384654,
-0.00624772,
-0.011818577,
-0.007637946,
-0.023212453,
0.0038222908,
-0.0073990524,
-0.010610838,
-0.012880323,
-0.0046949144,
-0.016576532,
0.00050723326,
-0.00558081,
0.011725673,
-0.011612863,
0.0037127982,
0.20311229,
-0.030711045,
0.02382296,
0.01885929,
0.013762902,
-0.007717577,
0.010597567,
0.005245696,
-0.0012575071,
0.001778427,
0.0068947226,
0.012488805,
0.0057997955,
-0.012342814,
0.028109765,
-0.005325327,
-0.013198848,
0.005643851,
-0.011214708,
-0.0031769474,
0.02015993,
-0.02038555,
0.02369024,
0.0042138104,
0.032914173,
0.006672419,
-0.018421318,
0.0107634645,
0.0135903675,
0.014599027,
-0.036471024,
0.008586883,
0.01986795,
0.0031703115,
0.019244174,
0.002946349,
0.0019194403,
-0.03039252,
0.0130528575,
-0.0311092,
-0.0030624778,
-0.00043838558,
-0.0018928966,
-0.0070805284,
-0.008507252,
0.014492853,
-0.00016786809,
0.0026908661,
0.013218756,
-0.00080584973,
-0.024884706,
0.016576532,
0.0064766593,
0.025468668,
0.0066226497,
-0.0015328979,
0.010119781,
0.0012881983,
0.009588907,
0.018169153,
-0.0009895818,
0.009482732,
-0.025389036,
0.015169716,
-0.016098745,
0.014054882,
-0.010192775,
0.01101563,
0.023225727,
-0.025521755,
-0.01339129,
0.004923854,
-0.024141483,
0.010663926,
0.0071535236,
-0.032064773,
0.043956343,
0.012342814,
0.037267335,
0.022270152,
0.019549426,
-0.009150936,
-0.035382733,
0.0019924354,
-0.0035833977,
-0.030684501,
0.033949375,
0.003958327,
-0.03429444,
0.0016647868,
0.0042735334,
-0.0066691013,
-0.010989086,
-0.0182886,
-0.0091443,
-0.0060386886,
-0.0015785198,
0.007890111,
-0.0020654306,
-0.014519396,
-0.033445045,
0.0580245,
0.010338766,
0.009117756,
-0.0006635922,
0.0088390475,
0.024154754,
0.012588344,
-0.0037957472,
-0.009296926,
0.031029569,
-0.01778427,
0.013298387,
-0.012568436,
0.0026991612,
0.020704076,
-0.0065828343,
-0.03981553,
0.039045762,
0.0043133493,
-0.011008994,
-0.015806764,
-0.0041872663,
0.021075686,
-0.009230567,
0.010624111,
-0.015355523,
0.008752781,
-0.04167359,
-0.020717347,
-0.0042901235,
-0.0009066328,
0.009588907,
0.017399386,
0.004167359,
-0.018567309,
0.004177313,
-0.009011582,
-0.037479684,
0.01130761,
-0.008434257,
-0.0026527096,
-0.019045096,
-0.015222805,
0.010159596,
-0.016828697,
0.025933182,
0.027167464,
-0.011831848,
-0.021301309,
-0.015687319,
-0.009568999,
-0.005185973,
-0.00024117428,
0.025070513,
-0.015660776,
-0.007863567,
-0.024260929,
-0.0045621963,
0.023358444,
-0.02224361,
0.03694881,
-0.0020504997,
-0.009515911,
-0.009084577,
-0.016948143,
-0.16680053,
-0.008434257,
0.025574842,
-0.017080862,
0.027339997,
0.009980426,
0.0042602615,
-0.016881784,
0.008095824,
-0.0031553807,
0.016815426,
0.018885832,
-0.029543122,
-0.0135041,
0.0029828467,
0.017611736,
-0.01885929,
0.03824945,
0.01599257,
0.016802153,
0.02053154,
-0.0074255965,
0.014346862,
0.0041806307,
0.004741366,
-0.013059494,
-0.0013562165,
-0.0196556,
-0.009568999,
-0.032595646,
-0.0014167692,
0.0058727907,
0.019496338,
-0.007843659,
0.015780222,
-0.016138561,
-0.0012790739,
0.0013728063,
0.0011297656,
0.023650425,
0.02211089,
0.00084856845,
-0.013026314,
0.0015403633,
-0.0055277226,
0.04140815,
-0.009084577,
0.0101463245,
0.015103358,
0.00798965,
0.004164041,
-0.004472611,
-0.0047944533,
-0.008858955,
0.02938386,
-0.0064866133,
0.01858058,
-0.001137231,
-0.014771561,
0.009482732,
-0.009860979,
-0.0046186014,
0.04448722,
-0.0008008728,
0.0083015375,
-0.032807995,
0.010975814,
0.0130130425,
-0.026809122,
-0.0040445942,
-0.007983014,
0.0028949208,
0.01249544,
-0.00781048,
0.013086038,
0.005335281,
0.0061315917,
0.0056272615,
0.0029347364,
-0.0073260576,
-0.032781452,
0.02858755,
-0.027817784,
-0.014678659,
-0.025694288,
0.0077441204,
0.012004382,
0.01591294,
-0.027685065,
-0.020916425,
0.0057002567,
-0.022814298,
0.005003485,
0.0031918783,
0.032144405,
0.013603639,
-0.017253397,
-0.009588907,
0.0029529852,
-0.001785063,
0.014267231,
-0.01490428,
-0.0048342687,
-0.009197387,
0.058555372,
-0.014930824,
-0.027897414,
0.01980159,
0.044327956,
-0.0029795289,
-0.013789445,
0.0020123431,
-0.0045422884,
0.010026878,
-0.0006494908,
0.043372385,
-0.0073393295,
0.009369921,
0.00852716,
-0.016855242,
0.084515095,
0.0008294902,
-0.013192212,
0.0329938,
-0.0056405333,
-0.00019513757,
-0.12836526,
-0.021075686,
0.005504497,
0.03140118,
-0.01080328,
0.02051827,
-0.007890111,
0.033604305,
-0.0015478287,
0.03296726,
-0.003809019,
-0.04268225,
0.0036066235,
-0.023066463,
0.022933746,
0.0045223804,
0.006834999,
-0.009051397,
0.00044916893,
0.031268463,
0.0038587884,
-0.004893992,
-0.0018846018,
-0.0056040357,
-0.008593518,
0.017253397,
-0.039868616,
0.020823522,
0.017213581,
0.033365414,
0.025375765,
-0.016722523,
0.016881784,
0.0005740072,
-0.01936362,
0.0069610816,
-0.009343377,
-0.026676405,
0.038647607,
-0.008912043,
-0.0058230213,
-0.0060486426,
-0.00813564,
-0.0007087994,
0.0046119657,
0.0057002567,
-0.012017654,
0.0031454267,
-0.0008543749,
-0.023477891,
-0.055210866,
-0.015687319,
-0.00781048,
0.014147785,
0.005663759,
-0.017041046,
0.011221344,
0.012966591,
-0.01047812,
-0.008706329,
-0.0020919743,
-0.01835496,
-0.016841969,
-0.0126480665,
0.019456523,
-0.02094297,
-0.020332463,
-0.047858268,
0.024526367,
-0.020226289,
-0.00896513,
0.0153024355,
-0.0021948311,
0.0006586152,
-0.026543686,
-0.0016747407,
-0.024778532,
-0.020133385,
0.011294339,
-0.026981657,
-0.0074189603,
-0.019337075,
0.014638843,
-0.010033513,
0.021380939,
-0.0024337242,
0.012548528,
-0.018036434,
-0.010637382,
0.011891572,
-0.019642329,
0.037108075,
-0.011241252,
-0.014439765,
-0.020929696,
0.010498028,
0.00057442195,
-0.00013728063,
0.0223896,
0.011154984,
-0.0066558295,
-0.020916425,
-0.04915891,
0.01915127,
0.00322174,
-0.013762902,
-0.0039981427,
-0.010179504,
0.0035933515,
-0.004575468,
0.012050834,
0.005156111,
-0.013709814,
0.01332493,
-0.03376357,
-0.0025050605,
-0.018593851,
-0.004167359,
0.031719707,
0.009071304,
-0.0013105945,
0.020252833,
-0.006294172,
-0.008613426,
0.004565514,
0.017757727,
-0.005185973,
0.010597567,
-0.023796415,
0.030259803,
-0.0054315017,
-0.009316834,
0.009874252,
-0.027419629,
-0.025309404,
0.019894494,
-0.004635191,
-0.009369921,
0.005146157,
0.040213685,
0.017412659,
0.024300745,
-0.00852716,
-0.027419629,
0.004728094,
-0.00507648,
-0.001394373,
0.022190522,
-0.01662962,
0.007518499,
0.0009066328,
-0.010949271,
0.033816658,
0.009117756,
0.008381169,
-0.009887523,
-0.0045522423,
-0.023318628,
-0.005428184,
0.003213445,
0.0026726173,
-0.015395338,
0.020000668,
0.00881914,
0.014373406,
-0.0067221886,
-0.013935436,
-0.029569667,
-0.018885832,
-0.0009895818,
-0.0077441204,
-0.03219749,
-0.01879293,
0.016072202,
0.00810246,
0.015528057,
0.00195262,
-0.001521285,
-0.012488805,
0.008606791,
-0.011367334,
0.017041046,
-0.00069096533,
0.010312222,
-0.022482503,
0.003055842,
0.038647607,
-0.015169716,
-0.02211089,
0.030073997,
-0.009907431,
0.01267461,
-0.0068084556,
0.001950961,
-0.0068880864,
-0.007053985,
0.02598627,
0.019443251,
-0.0031786065,
0.017996619,
0.004635191,
0.01778427,
-0.0044427495,
-0.0012367698,
0.0022976878,
-0.03434753,
-0.019854678,
0.013451013,
-0.034161724,
-0.04456685,
-0.0169216,
0.007710941,
0.003895286,
0.019522881,
-0.014293775,
0.00091409823,
-0.01872657,
0.012230003,
0.0013338203,
-0.022548862,
-0.009197387,
0.049371257,
0.01677561,
0.0024304064,
0.008195363,
0.010345402,
0.0088390475,
-0.00026709583,
0.02081025,
-0.012893596,
0.02570756,
-0.0026925253,
0.039045762,
0.04573477,
0.0047015506,
-0.019947581,
-0.001781745,
-0.019642329,
0.0010683833,
0.020836795,
-0.007345965,
0.084196575,
0.00810246,
-0.027313454,
0.00831481,
-0.01664289,
0.029144967,
0.015528057,
0.020266104,
-0.017598463,
-0.020425366,
0.033949375,
-0.025216501,
0.03219749,
-0.020239562,
-0.00660606,
0.00932347,
-0.008653242,
-0.00016258008,
-0.016934872,
-0.017107407,
-0.0075782225,
-0.013245299,
0.010989086,
0.029463492,
-0.041142713,
-0.024380377,
0.028720269,
-0.008912043,
0.00046492927,
0.008036101,
-0.01184512,
0.004300077,
-0.04536316,
-0.004814361,
0.0026626636,
0.018248785,
0.004903946,
-0.016032387,
0.03203823,
0.0100136055,
-0.0065562907,
-0.012614887,
-0.008513887,
-0.005769934,
0.0050167567,
-0.005424866,
-0.0027622024,
-0.00798965,
-0.0182886
] |
Hydroxyurea is a potent teratogen; free radical scavengers or antioxidants reduce its teratogenicity. Activator Protein-1 (AP-1) and NF-kappaB are redox-sensitive transcription factors with important roles in normal development and the stress response. This study was designed to determine if exposure to teratogenic doses of hydroxyurea induces oxidative stress and alters gene expression by activating these transcription factors. Pregnant mice were treated with saline or hydroxyurea (400, 500, or 600 mg/kg) on gestation day 9 (GD 9) and killed either on GD | [
-0.028370818,
-0.029761283,
-0.00036411945,
-0.027755804,
-0.019105513,
0.006905527,
-0.0077210874,
0.0051674466,
-0.020709895,
-0.021832962,
0.022715373,
0.000517246,
-0.0006446774,
0.0057256375,
-0.021365019,
-0.014867271,
0.03778319,
0.0061066784,
0.006343993,
-0.0079818,
-0.01843702,
0.00923188,
-0.007025855,
-0.018049296,
-0.013149246,
0.005200871,
0.005134022,
-0.0547629,
-0.002047258,
-0.026004355,
0.019453129,
0.011197248,
-0.010288098,
-0.00042094133,
-0.010468591,
0.003479503,
0.003666681,
-0.003833804,
-0.0025302437,
0.0065144585,
0.011939274,
0.021846332,
-0.005157419,
0.020776745,
-0.0028778599,
-0.012413904,
-0.007119444,
-0.022381127,
-0.002705723,
0.03195394,
0.011986069,
-0.0034995577,
0.01672568,
-0.0075405943,
0.0006242048,
0.013891272,
0.007039225,
0.031365663,
0.00037999617,
-0.010448537,
-0.00967977,
0.0032505444,
-0.047329262,
0.027140792,
-0.006327281,
0.01585664,
0.024480192,
0.008369525,
-0.01052207,
-0.009004593,
0.026726326,
0.016939597,
-0.0047797207,
-0.014345847,
0.006487719,
-0.013436697,
-0.051420435,
-0.006898842,
0.020389019,
-0.0015224915,
0.034922045,
-0.004158023,
-0.012387165,
-0.0021909839,
0.01942639,
0.01409182,
-0.02735471,
0.013162616,
0.01600371,
-0.013175986,
0.0039474475,
0.019854225,
0.025429452,
0.01763483,
-0.009519332,
0.013891272,
0.013089081,
0.042917214,
-0.0017781898,
-0.015696201,
-0.02026869,
0.008556703,
-0.0045190086,
-0.012594397,
-0.029681064,
0.008262566,
0.004920104,
0.01942639,
-0.0011447932,
-0.005685528,
-0.028557995,
0.039307356,
-0.0027809285,
-0.029413667,
-0.004395338,
-0.008195717,
0.018022556,
0.012320315,
-0.005996377,
-0.0005423145,
0.01858409,
0.019720526,
0.017875487,
-0.028076682,
0.020495977,
0.021512086,
-0.020402389,
-0.008068703,
-0.013877902,
-0.0031937226,
0.0035095853,
0.0066214176,
0.031258706,
-0.0070927045,
-0.03682056,
0.03438725,
-0.027568627,
-0.019880965,
-0.020108253,
-0.033023525,
0.011016755,
0.022581674,
-0.008790676,
0.001421382,
-0.013998231,
0.007233088,
0.016551873,
0.012581027,
0.0014138614,
0.010461906,
0.0012868479,
-0.0038204342,
0.015442175,
-0.012213357,
-0.012106398,
0.005745692,
0.0035496948,
0.002857805,
-0.034547687,
-0.00137793,
0.02457378,
-0.023891918,
0.009780044,
0.0071060746,
-0.011945959,
0.026258383,
0.0147335725,
-0.0039140233,
0.016685572,
-0.017220365,
-0.016993077,
0.010401742,
-0.017567981,
0.0017965734,
0.017755158,
0.014305738,
0.00056487607,
0.014466176,
-0.013069027,
-0.0048666247,
-0.003066709,
0.01319604,
0.021391757,
0.0036365988,
-0.0063239383,
0.0043017487,
0.012701356,
-0.017474392,
0.008529963,
-0.025228905,
-0.0060064043,
0.00015291764,
-0.013022232,
-0.013904642,
-0.6426084,
-0.012213357,
-0.00095928664,
-0.0014990943,
0.004261639,
0.039227135,
0.020723265,
0.008162293,
-0.022528194,
0.035162702,
-0.0015325189,
0.029681064,
0.0074336356,
-0.01407845,
-0.0022177235,
-0.023009509,
-0.012875164,
-0.026151424,
0.025255643,
0.0058626784,
-0.023744851,
0.0028193668,
-0.026712958,
-0.0027725722,
0.012768205,
0.036686864,
0.0221271,
-0.0057624048,
-0.0017932309,
0.03438725,
0.014947491,
0.012113082,
0.008423004,
0.012895219,
0.042649817,
-0.0027792573,
0.0016553544,
0.027836025,
0.016017077,
0.03449421,
-0.037275136,
0.0049234466,
0.03446747,
-0.0057590622,
-0.012921958,
0.024520302,
0.0134500675,
0.0053211995,
0.00923188,
0.008890949,
-0.004258297,
0.0039909,
-0.00274249,
0.004355228,
0.009185086,
0.013229465,
0.0055217473,
-0.016846009,
0.0066515,
-0.005134022,
-0.000019963378,
0.026819916,
0.00085232785,
-0.0037535848,
-0.010849632,
0.0018333405,
-0.0028561337,
0.014746943,
-0.002025532,
0.0031703252,
0.029841501,
0.03628577,
0.00016085598,
0.009699825,
0.021659154,
0.020161731,
0.0037535848,
-0.00047003373,
-0.0017932309,
0.043799624,
0.012875164,
0.0033959416,
-0.034601167,
0.012347055,
0.034948785,
-0.015682831,
-0.032889828,
0.029467145,
0.01277489,
-0.033210702,
0.008509909,
0.0050370903,
-0.0046192827,
-0.03596489,
-0.01679253,
0.0000860684,
-0.002690682,
0.019105513,
0.0115181245,
-0.027461668,
-0.02818364,
-0.013677355,
-0.01407845,
0.0010169441,
0.0066581843,
-0.0022544907,
-0.040002584,
-0.008797361,
0.037542533,
-0.0044387896,
-0.010595605,
0.017113406,
-0.01413193,
-0.013904642,
0.019733896,
-0.02028206,
0.0022361071,
-0.001045355,
-0.011397796,
-0.034039635,
0.024105836,
0.017059926,
0.013042287,
-0.009866948,
0.003405969,
0.0021174497,
0.010629029,
-0.0051239943,
-0.0010420126,
-0.03775645,
0.0334781,
0.008082073,
0.0013302999,
-0.020616306,
0.03171328,
-0.012901904,
0.02033554,
0.011310891,
0.025897397,
-0.017086666,
-0.038264506,
-0.0065144585,
-0.01052207,
0.013650615,
-0.010856316,
-0.014439437,
-0.000797595,
0.012246781,
0.0023664632,
0.0078213615,
-0.001356204,
-0.0002907942,
-0.011424535,
0.0221271,
0.023089727,
-0.006698294,
-0.0054582404,
-0.025416082,
-0.0025837233,
0.00037017767,
0.009512647,
0.026699588,
-0.017367434,
0.015535763,
-0.032996785,
-0.014238888,
-0.009526017,
0.006467664,
-0.0066314447,
-0.005966295,
-0.014639984,
-0.03091109,
-0.023276906,
0.015575874,
-0.0016971352,
0.008703771,
-0.008202402,
0.0023330385,
-0.01410519,
-0.009078127,
-0.005976322,
-0.008409634,
-0.027287861,
-0.019961184,
0.017822009,
0.023437344,
-0.0081288675,
0.014519655,
0.0077210874,
0.038317986,
-0.03270265,
0.015014339,
-0.017848747,
0.01760809,
-0.0039875573,
-0.0615013,
-0.00031586268,
0.006938951,
0.009111552,
0.046393372,
0.02734134,
-0.019199103,
0.011785521,
-0.019840855,
0.016351325,
-0.012621136,
-0.011805576,
-0.009292045,
0.002792627,
-0.018009186,
-0.003833804,
0.0070993896,
-0.0007934169,
-0.017340694,
-0.018637568,
-0.015308476,
-0.020816853,
-0.0017330666,
-0.0055351174,
-0.02477433,
0.022554934,
-0.010094236,
0.018116144,
0.0051173093,
-0.015281737,
-0.016538503,
0.0047061867,
0.011324261,
0.008656977,
0.0060799387,
0.009793414,
-0.0037001055,
0.0054315007,
-0.015910119,
0.018757896,
-0.015188147,
-0.025228905,
-0.015201517,
0.018156255,
0.002329696,
0.0060732537,
-0.0299752,
0.022220688,
0.013824423,
0.01676579,
-0.014519655,
0.041927844,
-0.005150734,
-0.012440644,
0.0040878314,
-0.007881526,
0.016498392,
-0.017059926,
0.0030499967,
-0.018249843,
-0.00274249,
0.015776422,
0.013436697,
0.0442542,
0.010354947,
0.02917301,
-0.0014873956,
0.00064258836,
0.0035831193,
0.0063607055,
0.014212149,
0.009646346,
-0.007139499,
0.010943221,
-0.01407845,
-0.0423022,
-0.00003517419,
0.011945959,
-0.0031135033,
0.01052207,
0.0060732537,
0.0075472794,
0.022060249,
0.012581027,
-0.01277489,
-0.004107886,
-0.0076475535,
0.031499363,
0.033905935,
-0.008229142,
0.0022177235,
-0.027434928,
-0.0072197183,
-0.0025152026,
0.01673905,
0.017059926,
0.015295107,
0.019439759,
0.014212149,
-0.023744851,
-0.020977292,
0.03075065,
-0.010274729,
-0.015455545,
-0.020683154,
-0.00082015665,
-0.0041613653,
-0.01599034,
0.021846332,
0.02203351,
0.013476807,
0.019025294,
-0.0053980765,
0.0023915316,
-0.019025294,
0.010368317,
-0.00484657,
0.00923188,
0.0052777478,
-0.016618721,
0.004268324,
-0.009526017,
0.011397796,
0.025055096,
-0.009927113,
-0.012159877,
-0.02295603,
0.00028264694,
-0.017367434,
0.014626614,
0.028584735,
-0.012266836,
0.0221271,
0.014426067,
0.02119121,
0.0145731345,
-0.027408188,
0.016993077,
-0.027047204,
-0.0035664071,
-0.0058827335,
0.015027709,
-0.013864533,
-0.003783667,
0.01857072,
0.006628102,
-0.035697494,
-0.022060249,
0.005822569,
0.013717464,
-0.0074737454,
0.015415435,
0.030162377,
0.02546956,
0.011665192,
0.01496086,
0.010655769,
0.014439437,
-0.015669461,
-0.0048699672,
0.013162616,
-0.015148038,
0.009626291,
0.008904319,
-0.029547365,
0.01762146,
-0.00019438507,
0.021766113,
0.0095928665,
0.023731481,
0.015722942,
0.010381687,
-0.0072932523,
0.0019102171,
-0.012126452,
0.008650292,
-0.0046326523,
-0.01859746,
-0.028798653,
0.011959329,
-0.02901257,
-0.020161731,
-0.008282621,
0.0060999934,
-0.015041079,
-0.0053847064,
0.0009534373,
-0.012928643,
-0.025309123,
-0.0037702972,
-0.004529036,
0.009526017,
-0.012614452,
-0.0060064043,
-0.003827119,
-0.008155608,
-0.02291592,
-0.017273843,
0.014787052,
0.014212149,
-0.014332477,
-0.027916243,
0.03157958,
0.039815407,
0.019800745,
0.010014016,
-0.017300583,
0.013476807,
0.015295107,
-0.023664631,
-0.0132896295,
-0.00707265,
-0.01847713,
0.019947814,
-0.007226403,
0.008316046,
-0.011437905,
-0.016926227,
0.0062671164,
-0.006691609,
-0.020442499,
0.005618679,
-0.011083604,
-0.011437905,
-0.0020957238,
0.0068085953,
0.022808962,
-0.012955383,
0.008215772,
-0.01671231,
-0.02365126,
-0.026258383,
-0.031552844,
-0.0076208133,
-0.020175101,
0.0033458045,
0.014720203,
-0.008496539,
-0.019827485,
0.013563711,
0.004729584,
0.0038939684,
-0.0124874385,
0.018182993,
0.011304207,
0.011210618,
0.019573458,
-0.019118883,
0.016391434,
0.0052276105,
-0.028771915,
0.024948137,
0.020014662,
-0.009211825,
0.008382895,
-0.010408427,
-0.016311215,
-0.015468915,
-0.007667608,
-0.004298406,
0.044147238,
0.0019135595,
-0.02117784,
-0.014212149,
-0.008175663,
-0.0005652939,
0.009632976,
0.015936859,
-0.01934617,
-0.008971169,
0.0074269506,
-0.018223103,
-0.028424298,
0.037435576,
-0.025081836,
-0.0057323226,
0.027568627,
-0.01405171,
-0.012815,
0.00006089548,
-0.021017402,
-0.026552519,
-0.0068152803,
-0.03088435,
-0.033879194,
0.012768205,
-0.0029396955,
0.032141116,
0.029600844,
0.03778319,
-0.0013896286,
0.0044855843,
0.021873072,
0.018343432,
0.0142656285,
-0.006133418,
0.038184285,
-0.006938951,
0.008904319,
-0.010936536,
0.004896707,
0.005331227,
-0.021766113,
0.012293575,
0.031900458,
-0.022835702,
-0.033745497,
0.009078127,
-0.036767084,
-0.014292368,
0.02121795,
-0.017902227,
0.0009300401,
-0.029253228,
0.00617687,
0.037596013,
0.0077678817,
0.018691048,
-0.008483169,
0.02294266,
-0.02105751,
0.006865417,
0.0017447652,
0.019653678,
-0.0007858964,
0.015214887,
0.024801068,
-0.013797684,
0.018009186,
0.016284475,
0.008964484,
-0.0071060746,
-0.0021007375,
0.00352964,
0.008008539,
-0.0139313815,
-0.0064342394,
-0.013276259,
-0.0115248095,
-0.019707156,
-0.0062804865,
0.011651822,
-0.03706122,
-0.0058760485,
0.017206995,
-0.014185409,
0.005505035,
-0.00615013,
-0.016418174,
0.009185086,
-0.024038987,
0.017206995,
-0.022274168,
0.01679253,
0.026993724,
0.0068854718,
-0.002886216,
-0.01676579,
0.0011230672,
0.010949906,
0.025924135,
0.0019219157,
-0.021699265,
-0.022635153,
-0.0070124855,
0.014238888,
-0.0077144024,
-0.035537057,
0.0175145,
-0.001938628,
-0.00055651995,
-0.0024934767,
-0.018931706,
-0.030456515,
0.020348908,
-0.0007332526,
-0.010314838,
0.007747827,
0.016057188,
-0.011745412,
0.014519655,
0.0033090375,
0.008636922,
0.010468591,
-0.013416643,
-0.0041546803,
-0.03612533,
-0.0036700233,
0.0016561899,
-0.023250166,
0.028905611,
0.0039173653,
0.024533672,
-0.00791495,
-0.026606,
0.0020305456,
0.0014297381,
0.0057891444,
0.042943954,
-0.008369525,
-0.0070860195,
0.031285446,
0.03350484,
-0.015936859,
-0.0046928166,
-0.013757574,
-0.012213357,
-0.029681064,
0.0039039957,
-0.00016252721,
-0.0042783516,
-0.027073942,
-0.008797361,
-0.021512086,
0.0047563235,
-0.0184905,
-0.03540336,
0.005040433,
-0.031419143,
-0.00007452646,
0.0019703815,
-0.003659996,
0.0053145145,
-0.0037602698,
-0.010702563,
-0.007828047,
0.026672848,
-0.016271105,
0.013002178,
-0.000112703645,
0.019961184,
-0.017835377,
0.014853901,
-0.027167533,
-0.019921074,
0.010929851,
-0.009178401,
-0.0491743,
-0.025068466,
-0.011330946,
0.0067517734,
0.018664308,
-0.013643931,
0.027622107,
-0.0031369007,
0.024854548,
-0.008008539,
0.0045089815,
0.015629353,
-0.009412373,
0.019279322,
0.034146592,
-0.014947491,
-0.014894011,
-0.010542125,
-0.011925905,
0.01011429,
-0.027100682,
0.005832596,
-0.011203933,
0.024520302,
-0.021779483,
-0.0025619972,
-0.012574342,
-0.011979384,
-0.024105836,
0.013784314,
0.010254674,
-0.026097944,
-0.02024195,
-0.01410519,
-0.014466176,
0.0026288463,
-0.009499277,
0.011498069,
-0.002301285,
-0.010475276,
-0.029574104,
0.0052042133,
0.011310891,
0.021645784,
0.014920751,
-0.030670432,
-0.015696201,
-0.018798007,
-0.038986478,
-0.019880965,
-0.013095766,
0.00069356087,
0.0026706273,
-0.0099070575,
0.012915273,
0.0063306233,
-0.006287171,
0.011177193,
-0.0077077174,
-0.0025703534,
-0.011397796,
-0.0026305176,
0.04136631,
-0.008570073,
-0.048933644,
-0.01847713,
0.033290923,
-0.005792487,
-0.008168978,
0.031044789,
-0.008155608,
0.025817176,
-0.014706833,
0.011137084,
0.0021759428,
-0.0018684363,
0.027889503,
-0.019065404,
-0.006684924,
0.013851163,
0.019453129,
-0.00551172,
-0.009973907,
0.0015450531,
0.0074470057,
-0.0014013272,
-0.00067601295,
-0.010107606,
0.018383542,
-0.019560087,
0.0038304615,
0.029386926,
-0.010776098,
0.00025360932,
0.02291592,
-0.021004032,
-0.010301468,
-0.0014280669,
-0.0012868479,
0.0043117763,
0.005287775,
0.008001855,
-0.018182993,
-0.0039474475,
0.002712408,
-0.013376533,
-0.009318784,
0.013269574,
-0.040109545,
-0.022621782,
0.012942013,
-0.017394172,
-0.0017698336,
-0.009419058,
0.0009709852,
-0.0008874237,
-0.00040631805,
0.00594624,
0.013864533,
-0.023303645,
-0.01763483,
0.0018166282,
-0.0099070575,
0.023357125,
-0.0076341834,
0.0009651359,
-0.00484657,
0.042221982,
0.18471782,
-0.0020121622,
0.010348262,
0.0022728741,
-0.0013186013,
0.009465853,
0.02028206,
-0.018370172,
-0.0032889827,
-0.0064409245,
0.029681064,
0.009238565,
-0.024413344,
-0.002329696,
0.010421797,
-0.0017497789,
-0.022635153,
0.009452483,
-0.025295753,
-0.0066581843,
0.016672201,
-0.006541198,
0.00062211574,
-0.0011832316,
0.026726326,
0.019479869,
-0.0144126965,
0.014800422,
0.004475557,
0.0016327928,
-0.020990662,
-0.0012826698,
-0.0020739976,
0.012199987,
0.017955706,
-0.020429129,
-0.025282383,
-0.006170185,
-0.012520863,
-0.020937182,
-0.011083604,
0.022661893,
-0.028023202,
0.0044889264,
-0.018303322,
0.018035926,
0.004268324,
-0.03157958,
-0.0036499687,
0.0002692771,
-0.03708796,
0.016846009,
0.0052342955,
0.018650938,
-0.021739373,
0.0027224354,
0.013109136,
-0.0040811463,
-0.008911004,
0.024426714,
-0.011478015,
0.0010328208,
-0.03714144,
0.013837793,
-0.024373233,
0.028638216,
-0.018904965,
-0.014011601,
-0.0025252302,
-0.017862117,
-0.020442499,
0.010147715,
-0.013329739,
0.017166885,
-0.0039173653,
-0.018811377,
0.0039474475,
0.016431544,
0.02033554,
0.0014782038,
0.012019494,
0.0027942983,
-0.020215211,
0.01767494,
-0.016939597,
-0.04150001,
0.012895219,
0.024801068,
-0.0032288183,
0.0097533045,
-0.0011247385,
-0.013630561,
-0.011337631,
-0.014813792,
-0.026860025,
-0.009532702,
-0.0077678817,
0.014038341,
-0.011130399,
0.013704094,
-0.03690078,
0.06321264,
-0.007233088,
0.010929851,
-0.013557026,
0.02121795,
0.017100036,
0.028664954,
-0.011123714,
0.0066949516,
0.017140146,
-0.025710218,
0.0032238048,
-0.010181139,
0.0021241347,
0.02284907,
-0.027047204,
-0.034200072,
0.032381773,
0.006096651,
0.012173247,
-0.03291657,
-0.0013787656,
0.01228689,
-0.011096974,
-0.009004593,
-0.007741142,
-0.00023313673,
-0.020054772,
-0.040002584,
-0.0016261078,
-0.0036065166,
0.014787052,
0.013035602,
0.0037335302,
-0.01847713,
0.010916481,
-0.004368598,
-0.013704094,
0.021645784,
0.0067885406,
-0.014372587,
0.013443382,
0.0089377435,
-0.00615013,
-0.035590537,
0.02105751,
-0.010375002,
0.00067392393,
-0.007159554,
-0.012206672,
-0.01669894,
0.005692213,
-0.013677355,
0.013837793,
-0.03805059,
-0.030215858,
-0.020843593,
0.013984862,
0.005969637,
-0.02719427,
0.022835702,
0.006952321,
-0.0027241067,
-0.016872749,
-0.00639413,
-0.168674,
-0.00264723,
0.028718434,
-0.014559764,
0.020161731,
0.012574342,
0.009632976,
-0.0019469842,
-0.019774005,
-0.004014297,
0.0336118,
-0.007487115,
-0.04583184,
-0.02119121,
0.012768205,
0.01228689,
-0.010595605,
0.056741636,
0.029681064,
0.0057690893,
0.006450952,
-0.010455221,
0.017126776,
-0.00020556142,
0.01854398,
0.02546956,
0.0049134195,
-0.02108425,
-0.00159519,
0.00091416336,
-0.0077344575,
0.0149876,
0.013369848,
0.011297522,
0.014533025,
-0.00790158,
0.008563388,
0.0070993896,
-0.005692213,
0.017928967,
0.0058359387,
-0.0017013132,
0.0064275544,
-0.0057423497,
-0.020415759,
0.05385375,
0.0033357772,
0.013169301,
0.037676234,
-0.00036975986,
0.030322816,
-0.0065712803,
0.00883747,
0.012607767,
0.019132253,
-0.011096974,
-0.0022511482,
0.020643046,
0.006654842,
-0.0038037219,
-0.012146507,
-0.01359045,
0.035109222,
0.0024383261,
0.01406508,
-0.020175101,
-0.0010395057,
0.012661247,
-0.05109956,
-0.0017915596,
-0.036579903,
-0.013864533,
-0.0032438594,
-0.0072865672,
0.0076007587,
-0.013430012,
-0.00548498,
0.014787052,
0.005187501,
-0.0014782038,
-0.02648567,
0.00461594,
-0.025135314,
-0.019185733,
-0.0022344359,
-0.006460979,
0.008663662,
0.039280616,
-0.026164792,
-0.01061566,
0.018677678,
-0.025148684,
0.0066882665,
-0.024012247,
0.02648567,
0.0021659154,
0.0012158205,
-0.00329901,
-0.007420266,
-0.024506932,
0.025068466,
-0.0299752,
-0.011264097,
-0.007828047,
0.047971018,
-0.015589243,
-0.0064108423,
0.0013336424,
0.05561857,
-0.003740215,
0.00077252655,
-0.0021542169,
0.006133418,
0.026084574,
0.0063907877,
0.030670432,
0.009378948,
0.01016777,
-0.0020572855,
-0.040697817,
0.06438919,
0.023972139,
-0.0029915036,
0.015936859,
-0.0051173093,
-0.031793498,
-0.1326289,
-0.020001292,
-0.0046125976,
-0.012226726,
-0.009820154,
0.022688633,
0.006200267,
0.032435253,
-0.0015509024,
0.02200677,
-0.029279968,
-0.00834947,
-0.005428158,
-0.019292692,
0.018731158,
0.009124922,
0.03813081,
0.013904642,
-0.013309684,
0.047382742,
-0.024547042,
-0.0048265154,
0.0021291485,
0.007854786,
0.001171533,
-0.0059395554,
-0.031873718,
0.0065645957,
-0.0016093955,
0.018878225,
0.018731158,
-0.0051039397,
0.032114375,
-0.01766157,
-0.024279645,
-0.015482284,
0.0011038481,
-0.027408188,
0.028852133,
-0.018985184,
0.0072531425,
-0.0040911734,
0.017594721,
0.001743094,
0.027622107,
-0.008743881,
-0.023076357,
0.0035196126,
0.028825393,
-0.028825393,
-0.030536734,
-0.00441205,
-0.002169258,
-0.0087839905,
0.014706833,
-0.009305415,
0.024440084,
0.01850387,
-0.02557652,
0.007139499,
0.032729387,
-0.01762146,
-0.023129838,
0.0099003725,
0.019078774,
-0.0211511,
-0.006039829,
-0.029681064,
0.017260475,
-0.029493885,
-0.009579496,
0.0004466365,
0.0022895865,
0.00018613336,
-0.013089081,
-0.0013152588,
-0.031820238,
-0.00096095784,
0.019025294,
-0.0108763715,
-0.014238888,
-0.009124922,
0.0070860195,
-0.023196686,
0.03075065,
0.01319604,
0.0020205183,
-0.00016064709,
-0.0056955554,
0.0041981325,
-0.02826386,
0.0546292,
-0.013022232,
-0.037676234,
-0.013262889,
0.021806223,
0.014172039,
-0.0030366268,
0.02365126,
0.023932029,
-0.007988485,
-0.038478423,
-0.06433571,
0.00883747,
-0.00085441687,
0.0031335582,
0.005779117,
0.0042549544,
-0.0038170917,
0.017140146,
-0.013303,
-0.0102279335,
-0.015281737,
-0.0011481358,
-0.016257735,
-0.015950229,
-0.005468268,
-0.0006969033,
0.020897074,
-0.004204817,
0.03690078,
-0.0012333685,
-0.004298406,
-0.005474953,
0.003934078,
0.008082073,
0.01584327,
-0.012875164,
-0.008603497,
-0.006865417,
0.010134345,
-0.002805997,
0.008857525,
-0.02719427,
-0.008342786,
0.00329901,
-0.009392318,
-0.023678001,
-0.005611994,
0.011564919,
0.017140146,
0.008977853,
-0.028397558,
-0.024667371,
-0.0076141288,
-0.013055657,
0.0031953938,
0.005388049,
-0.028584735,
0.00035680784,
-0.0058426238,
-0.019934444,
0.03409311,
0.0238117,
-0.008971169,
-0.005825911,
-0.04417398,
-0.013476807,
-0.014533025,
-0.00970651,
-0.018677678,
-0.009526017,
-0.011324261,
0.0077077174,
-0.010682509,
0.0077946214,
0.0036098592,
-0.018209733,
0.0068319924,
-0.017327324,
0.023437344,
-0.0022611755,
-0.028397558,
-0.0030149007,
0.002388189,
0.0032572292,
0.012815,
0.0020506005,
-0.010040756,
0.012347055,
-0.021538826,
0.021338278,
-0.0026054492,
-0.018704418,
-0.018102774,
0.017875487,
0.025790438,
0.00014633717,
-0.01750113,
0.0045390637,
0.00883747,
0.0013336424,
-0.014198779,
0.0061969245,
-0.0021274772,
0.014332477,
-0.012006124,
0.013637246,
0.0013336424,
-0.007935005,
0.0066147326,
0.053987447,
0.016137406,
-0.0058292537,
0.011571604,
-0.010769413,
-0.016297845,
0.013958122,
-0.018009186,
-0.02810342,
-0.005989692,
-0.002344737,
0.011979384,
0.018383542,
0.0075940737,
0.0026572573,
0.0043986803,
0.007754512,
0.0024700796,
0.0051607615,
-0.0030683803,
0.04115239,
0.003479503,
0.010508701,
0.0065645957,
-0.0017698336,
0.04519009,
0.002682326,
0.04759666,
-0.027862763,
0.04478899,
-0.033825718,
0.021525456,
0.00018352206,
-0.024547042,
-0.01193259,
0.007319992,
-0.030082159,
0.020495977,
0.028049942,
-0.0029848185,
0.08717141,
0.015014339,
-0.032461993,
-0.013483492,
0.01497423,
0.014292368,
0.020910442,
0.004659392,
0.00461594,
-0.016846009,
0.035109222,
-0.03355832,
0.020482607,
-0.019640308,
-0.031258706,
0.0023263537,
0.020108253,
0.004475557,
-0.010782783,
-0.008590127,
0.028049942,
0.01101007,
0.009472538,
0.020469237,
-0.039387573,
-0.012982123,
0.026231643,
-0.02810342,
0.0044020223,
-0.02211373,
-0.013530287,
0.0026806546,
-0.0150678195,
-0.013182671,
0.024079097,
-0.0072598276,
-0.006327281,
-0.002610463,
0.013530287,
0.0060431715,
0.004736269,
0.019453129,
-0.005301145,
-0.013877902,
-0.00799517,
-0.0110368095,
-0.026739696,
-0.004512324,
-0.0030199145
] |
BCL-6, a transcriptional repressor frequently translocated in lymphomas, regulates germinal center B cell differentiation and inflammation. DNA microarray screening identified genes repressed by BCL-6, including many lymphocyte activation genes, suggesting that BCL-6 modulates B cell receptor signals. BCL-6 repression of two chemokine genes, MIP-1alpha and IP-10, may also attenuate inflammatory responses. Blimp-1, another BCL-6 target, is important for plasmacytic differentiation. Since BCL-6 expression is silenced in plasma cells, repression of blimp- | [
-0.027260074,
-0.008300646,
0.009648154,
-0.028728858,
-0.016480016,
0.020536013,
-0.011359488,
0.02385088,
-0.028135955,
-0.01898638,
-0.0006729115,
-0.0054203486,
0.0074247657,
0.018919004,
-0.020468637,
0.0048813457,
0.02902531,
-0.0066196304,
-0.0060772584,
0.026653698,
-0.025926042,
0.025481366,
0.011696365,
-0.025009738,
-0.024915412,
0.0035237318,
0.020172186,
-0.043901794,
-0.0055113053,
-0.0019201981,
0.015860163,
0.006932926,
-0.0077414303,
0.030211117,
-0.029591262,
-0.028324606,
0.0152268335,
-0.032474928,
0.017140295,
0.004042522,
0.033391234,
0.02363528,
-0.022921102,
0.00848256,
0.023487054,
0.0053664483,
0.02366223,
-0.009513402,
0.004685957,
0.013232523,
0.017989224,
0.0049689338,
-0.0002442357,
-0.0024625699,
-0.01540201,
-0.01704597,
0.010672259,
0.033310384,
-0.00030339972,
-0.011716577,
-0.012329693,
-0.01036907,
-0.028540207,
0.0023160283,
0.0227594,
0.014067978,
0.0077414303,
0.0010721106,
0.019161556,
-0.023055851,
0.051259182,
0.028001204,
-0.0062086405,
0.0047095385,
0.007829018,
-0.0112719,
-0.03441534,
0.012754158,
-0.0022604438,
-0.004456881,
0.02273245,
0.008603835,
-0.002695015,
0.0010358964,
0.023675706,
-0.0012843431,
0.010126518,
-0.0021290618,
-0.017881423,
-0.0062254844,
-0.002656274,
0.025023213,
0.037864957,
0.02639767,
-0.019309781,
0.013535712,
0.01972751,
0.029833814,
-0.0032357022,
-0.022772875,
-0.0071417894,
0.0010426339,
-0.01633179,
-0.010106306,
-0.02897141,
-0.007802068,
-0.014216203,
-0.013751313,
0.020495588,
0.009776167,
-0.039401118,
0.01458003,
0.00021412736,
-0.05082798,
0.058751322,
-0.019552333,
0.007754905,
-0.02166792,
0.0011959128,
-0.031558625,
0.0023261346,
0.0357898,
0.0036450075,
-0.03848481,
0.018919004,
0.0013416121,
-0.014916907,
0.0017618659,
-0.031235222,
0.0019707296,
0.004527625,
0.03985927,
-0.013987127,
-0.007377603,
-0.022516849,
-0.009014824,
0.016480016,
-0.023527479,
-0.006737537,
-0.009297801,
-0.0056662685,
0.037864957,
-0.0026815399,
0.0009196738,
0.0011226421,
0.028728858,
0.005430455,
0.0003813025,
-0.007876181,
0.014270104,
-0.03236713,
-0.021290617,
0.015550235,
0.0020751616,
0.022153022,
0.0023429785,
0.0012178099,
0.04387484,
-0.009237164,
-0.009405602,
0.0033586624,
-0.008543197,
0.009203476,
0.031235222,
0.03832311,
0.02560264,
-0.010530771,
-0.015967963,
-0.016210515,
0.012248843,
0.011918703,
0.01994311,
-0.022921102,
0.015833212,
-0.007512354,
0.025198389,
0.013111248,
0.010537508,
-0.012457706,
-0.003036945,
-0.021964371,
0.018919004,
0.004935246,
-0.00023139229,
-0.019700559,
0.0024474103,
0.021614019,
-0.022031747,
-0.0055146744,
-0.030157216,
0.0031279016,
0.013198835,
0.019687083,
-0.031289123,
-0.6239498,
-0.0076134168,
0.019821834,
-0.00036845906,
0.008812699,
0.015765836,
0.012787846,
-0.007566254,
-0.022004796,
0.031343024,
-0.0004124636,
0.021465793,
0.00949319,
-0.020158712,
-0.004032416,
-0.057727218,
-0.014270104,
-0.015145984,
0.045114547,
-0.008758798,
-0.009499927,
-0.01643959,
-0.018043125,
0.036894754,
-0.022772875,
0.011541401,
0.023985632,
-0.015873637,
0.016830368,
0.016170088,
-0.005046415,
0.015590661,
-0.0041435855,
0.0038336585,
0.047998216,
0.024982788,
-0.0053361296,
0.019538857,
0.03312173,
0.037164256,
0.005673006,
-0.005720169,
0.023904782,
0.00451415,
-0.01707292,
0.0147282565,
0.010483608,
0.025993418,
0.01835305,
-0.015065133,
-0.009702054,
-0.0004133058,
-0.0070811515,
0.002669749,
0.015361585,
0.0066128927,
0.021075016,
-0.006959876,
0.013656988,
-0.014162303,
-0.0017702879,
0.027785603,
-0.027502626,
-0.018097024,
0.0026596428,
-0.008650998,
-0.020495588,
-0.02095374,
0.020266512,
0.028109005,
0.006794806,
0.0059189266,
0.00009606254,
-0.0035271007,
0.012888908,
0.02549484,
-0.018029649,
-0.0027051212,
0.018312626,
0.007451716,
-0.0059020827,
-0.013374011,
-0.02073814,
0.0051474785,
0.023406204,
-0.0063366536,
0.0014729941,
0.009223688,
-0.012713732,
0.0025973206,
0.033768535,
0.0062389593,
-0.025858667,
-0.034954343,
-0.023460105,
0.031720325,
-0.0031919081,
0.023217553,
0.009533615,
-0.032097626,
-0.01652044,
-0.0005166849,
0.005036309,
0.0044770935,
0.006350129,
0.003813446,
-0.035439447,
0.013367274,
0.03075012,
-0.016453065,
-0.0008135576,
0.022934576,
-0.02002396,
-0.02164097,
0.018097024,
-0.02180267,
0.028109005,
0.010537508,
-0.0012691836,
-0.0360054,
0.010288219,
-0.0026006894,
0.00088514393,
-0.01184459,
-0.0009339911,
0.002836503,
0.008960924,
-0.010348857,
0.0010788481,
-0.0072428524,
-0.0055483617,
-0.00058532355,
0.023783507,
-0.01895943,
0.031693373,
-0.0027202806,
0.039293315,
0.015590661,
0.000053873977,
-0.029914664,
-0.026438097,
-0.01455308,
0.021533169,
0.008920499,
-0.002555211,
-0.0052148537,
-0.0032323333,
0.010220844,
0.016776467,
-0.00057100627,
0.0033906656,
-0.011777215,
-0.0010392651,
-0.0019943109,
0.02363528,
-0.009216951,
-0.028513256,
-0.006117684,
-0.022692025,
-0.01753107,
-0.014418329,
-0.0073978156,
0.0007301806,
0.0049891463,
0.0065994174,
-0.0181644,
0.02267855,
0.0363288,
-0.025077114,
-0.032771382,
-0.007930081,
-0.010335382,
-0.02177572,
0.014876482,
0.00727654,
-0.008684685,
-0.0009853648,
0.018770779,
0.008192846,
0.0013820373,
0.0077346927,
-0.030588418,
-0.0065994174,
-0.014243154,
0.02461896,
0.02063034,
0.021169342,
-0.005211485,
0.014148828,
0.02467286,
-0.017652348,
0.012464444,
-0.017760148,
0.029699063,
0.0021711714,
-0.015684986,
0.0049116644,
0.016601292,
0.01463393,
0.02445726,
-0.011554876,
0.00023686654,
0.011123674,
-0.008933974,
-0.0039111404,
-0.03799971,
-0.00042930743,
-0.0076471046,
0.005740382,
0.023338828,
0.0008245061,
0.017840998,
0.023082802,
-0.015631085,
0.004584894,
-0.00044341417,
0.006959876,
-0.016480016,
0.0073439153,
-0.013367274,
0.0030251541,
0.018258726,
0.03384939,
0.0003888822,
-0.009183263,
-0.0055146744,
0.015711937,
-0.002331188,
0.020293461,
0.004729751,
-0.0033805592,
0.012242105,
0.0068386,
-0.0025737393,
-0.0026966992,
-0.0009811538,
0.01633179,
0.0018258726,
0.03789191,
-0.015604136,
-0.010294957,
0.01540201,
-0.0030689482,
0.0064545604,
-0.0025164702,
-0.02721965,
0.01999701,
-0.0000032766538,
-0.0004290969,
-0.0015900588,
-0.016035339,
0.017086394,
-0.0073034903,
-0.0013340324,
0.0017938693,
-0.008448872,
0.0057875444,
0.0068082814,
0.04956132,
0.02191047,
0.021182816,
-0.02073814,
0.004136848,
-0.017571498,
0.0013508762,
0.001739969,
0.00087672204,
0.001783763,
-0.0079772435,
0.0072293775,
-0.021425368,
-0.009776167,
0.03266358,
-0.037784107,
0.015523286,
0.008266958,
0.01086091,
0.014903432,
0.02079204,
0.01031517,
-0.0022520218,
-0.028836658,
0.017005544,
0.03409194,
-0.017558021,
0.016560866,
-0.036867805,
0.0056089996,
0.011992816,
0.004719645,
-0.0058043883,
0.00867121,
-0.0091428375,
0.01184459,
-0.0045512062,
-0.00861731,
0.014822582,
-0.002459201,
-0.0010417916,
0.011022611,
0.0138928015,
-0.000569743,
-0.0021795933,
0.010220844,
0.02461896,
0.0045309938,
-0.009803116,
-0.024228184,
-0.024147334,
-0.013771526,
-0.005952614,
-0.018568652,
0.00012095985,
0.001950517,
0.0128956465,
-0.0020987429,
0.043686192,
0.0035169944,
0.0035877386,
-0.008031144,
-0.04015572,
-0.026640221,
0.0029392506,
-0.0046489006,
0.0113258,
0.0004006729,
-0.008624048,
0.017167244,
-0.019552333,
0.0059458767,
-0.028243756,
-0.0021155868,
0.011346012,
-0.019565808,
-0.019107655,
0.007263065,
0.01920198,
-0.008253483,
-0.020751614,
0.011217999,
-0.0036045823,
-0.00943929,
-0.007903131,
0.0065926802,
0.011366225,
-0.003550682,
0.007701005,
0.055059154,
0.0073034903,
0.0073304405,
0.0016616451,
0.009587515,
0.014337479,
-0.0181105,
0.0068588126,
0.012592457,
0.00568985,
0.0015277365,
0.013630037,
-0.024632435,
0.0091024125,
0.019242406,
-0.008132207,
-0.0053192857,
0.03983232,
0.015496335,
-0.0029291443,
0.0014452017,
-0.004059366,
-0.026815398,
-0.010800272,
0.0042884424,
-0.0042884424,
-0.03064232,
0.020050911,
-0.025979944,
-0.005999777,
-0.021021117,
-0.0016970171,
0.0012599195,
0.008004194,
0.0032340179,
0.012491394,
-0.0055988934,
-0.008624048,
-0.01622399,
0.009735741,
0.000422991,
-0.011332537,
-0.003607951,
-0.011891753,
-0.020536013,
-0.003028523,
-0.019565808,
-0.012410544,
-0.03452314,
-0.038592614,
0.010827222,
0.031801175,
0.011743527,
0.005245173,
0.0016911218,
0.005272123,
0.0043322365,
-0.003239071,
-0.034038037,
0.017598446,
-0.031801175,
-0.0017803942,
0.0011285375,
0.036598302,
-0.00044383525,
-0.017827524,
-0.013879326,
-0.0018528227,
-0.019026805,
0.028944459,
-0.008307383,
0.004086316,
0.016264414,
0.02440336,
0.02443031,
0.0047061695,
-0.014054502,
-0.0045444686,
-0.004696063,
-0.033499036,
0.0056426874,
-0.006171584,
-0.015887113,
0.0066600554,
0.0008316647,
-0.01652044,
-0.005558468,
0.006872288,
-0.015038183,
0.003178433,
-0.008455609,
-0.0047432263,
0.020576438,
-0.014148828,
0.018299151,
0.0181105,
-0.007316965,
-0.0005794282,
-0.014606981,
0.0127676325,
0.009883967,
-0.014647406,
0.0036719576,
-0.0045781564,
-0.0026057425,
-0.028567158,
-0.0039616716,
-0.012167992,
0.017908374,
0.004096423,
-0.0114336,
-0.02897141,
0.0068520755,
0.021492744,
0.020279987,
-0.0035473134,
-0.032313228,
-0.016601292,
0.003624795,
0.010416232,
-0.004133479,
0.018999854,
-0.029402612,
0.008388233,
0.032474928,
0.00013032924,
-0.006939663,
0.014647406,
-0.0003853029,
-0.025050163,
-0.02358138,
-0.011757002,
-0.013481812,
0.0034462502,
-0.02191047,
0.038781263,
0.033310384,
0.022099122,
0.006023358,
0.019633183,
0.02905226,
0.004861133,
0.004423193,
-0.0017736567,
0.026465045,
-0.010928285,
0.0091024125,
-0.004800495,
0.00326939,
0.042554285,
-0.02054949,
0.00957404,
0.027866453,
-0.017248096,
-0.014795631,
0.015145984,
-0.012929333,
-0.030345866,
0.015765836,
-0.017652348,
0.0026310082,
-0.020913316,
-0.0071687396,
0.025400516,
0.0041435855,
0.014472229,
0.0005958509,
0.027004048,
-0.014660881,
0.009621203,
0.0011765424,
-0.0030908452,
-0.0060941023,
-0.012787846,
0.009048512,
-0.010672259,
0.008691423,
-0.015792787,
0.016789943,
-0.018743828,
-0.016628241,
0.0025619485,
0.0024709918,
-0.015900588,
0.0023295034,
0.011891753,
-0.0050093587,
-0.011292112,
-0.024228184,
-0.021991322,
-0.044575546,
0.031423874,
0.020913316,
0.0009761007,
0.03455009,
-0.0081456825,
-0.003985253,
0.046596806,
-0.003917878,
0.024133857,
-0.029699063,
0.025589166,
0.014067978,
0.006939663,
-0.016453065,
-0.0099782925,
-0.013481812,
-0.0018511383,
0.033472084,
0.036813904,
-0.007829018,
0.010241057,
0.007087889,
0.023527479,
0.0011672783,
-0.025104063,
0.014822582,
-0.0063130725,
-0.0033350808,
-0.019269357,
-0.020589914,
-0.011029349,
-0.0108137475,
-0.015294209,
0.018636027,
-0.009789641,
-0.018676452,
-0.005373186,
0.012538557,
-0.0037662832,
-0.0015588977,
0.018919004,
-0.039643668,
-0.0013171885,
-0.02623597,
0.010584671,
-0.007121577,
-0.014391379,
0.035466395,
0.011662677,
0.009156313,
0.017787099,
0.0070542013,
0.011339275,
-0.0029594633,
-0.006656687,
0.04347059,
-0.006535411,
-0.0029560945,
-0.0130169215,
-0.00363827,
0.014364429,
0.0026411146,
-0.018420426,
0.0010628465,
-0.021331042,
0.013879326,
0.029860765,
0.006912713,
-0.01055772,
0.014647406,
-0.022880675,
-0.02164097,
-0.029968565,
-0.01712682,
0.0071956897,
-0.054088946,
0.015954487,
-0.018406952,
0.017854473,
0.022099122,
0.006114315,
0.0022604438,
-0.005585418,
0.034873493,
-0.028701909,
0.033957187,
-0.016601292,
-0.009688579,
-0.014135353,
0.015361585,
0.0028112375,
-0.031046571,
0.008893549,
-0.014593505,
-0.014202728,
-0.0006202745,
-0.02385088,
0.020994166,
0.0143105285,
-0.02661327,
-0.00035098358,
0.0034597253,
0.020724664,
-0.0070811515,
-0.002809553,
-0.0042008543,
-0.028701909,
0.0033283434,
0.014903432,
0.0022772877,
-0.006986826,
0.005817863,
0.0021054803,
0.018299151,
0.011116936,
-0.028836658,
-0.0006308019,
-0.0055079367,
0.008044619,
0.014741731,
-0.021694869,
0.0005895345,
-0.011757002,
0.023123227,
0.004935246,
0.0036146888,
-0.009203476,
-0.00029434616,
0.011676152,
0.014741731,
-0.014593505,
-0.00848256,
-0.0129764965,
-0.028674958,
-0.025656542,
0.0032811805,
-0.0270849,
0.03236713,
0.0031144265,
-0.0024861512,
-0.035897598,
-0.011588564,
-0.044791147,
-0.01044992,
0.01225558,
0.006777962,
-0.009648154,
0.029941615,
-0.015253784,
0.01641264,
-0.015267259,
0.03075012,
0.02891751,
-0.026033843,
0.005955983,
0.0081861075,
0.021977846,
0.012605932,
-0.027125325,
-0.020589914,
0.037110355,
-0.011568352,
-0.006649949,
0.039050765,
-0.020118285,
0.021843096,
-0.011346012,
-0.0000753762,
-0.004483831,
0.0066634244,
0.010119781,
-0.044117395,
-0.014175778,
0.015833212,
0.0037629146,
-0.002765759,
0.012208417,
-0.0007293384,
-0.005299073,
-0.0037763896,
-0.0060536773,
-0.028028155,
0.0138928015,
-0.0059324014,
0.017328946,
0.03985927,
0.018312626,
0.026909724,
0.010052405,
-0.013252735,
-0.01641264,
-0.018150926,
-0.016803417,
0.0064410856,
-0.00033603466,
0.0032070677,
-0.023567906,
-0.010045668,
-0.014324004,
-0.02459201,
-0.01321231,
-0.017719723,
-0.014849531,
-0.042877685,
0.011757002,
0.017935324,
-0.01225558,
-0.003624795,
-0.0056662685,
-0.018097024,
-0.042958535,
0.016830368,
-0.017881423,
-0.02174877,
0.00856341,
-0.0018814573,
-0.0118109025,
0.003252546,
-0.019700559,
-0.006026727,
-0.0019926266,
0.011514451,
0.18811204,
-0.018676452,
-0.0180566,
-0.0017315471,
-0.013030397,
-0.0005238435,
0.013192098,
-0.008307383,
-0.007950294,
0.023244504,
0.0037966021,
-0.000112327376,
0.008650998,
0.0022857094,
0.015631085,
0.008994612,
-0.023109753,
-0.015442435,
-0.014027553,
-0.014741731,
0.0081052575,
0.0010047352,
0.020320412,
-0.020468637,
0.035735898,
-0.0034378283,
-0.016533917,
0.04155713,
0.024106909,
0.0013534027,
-0.040263522,
0.031774227,
-0.0031582206,
-0.017773623,
0.002415407,
0.012531819,
-0.021357993,
-0.023352304,
-0.012134304,
0.00031898028,
-0.015024708,
-0.017328946,
-0.008839649,
0.001262446,
0.0074584535,
0.0047802827,
-0.010382545,
0.0010704262,
-0.012545294,
-0.012552031,
-0.043147188,
0.033445135,
-0.0017618659,
0.046677656,
0.009830067,
-0.007855969,
0.0271927,
0.010692472,
-0.020199137,
0.016789943,
-0.014418329,
-0.0005015254,
-0.031181322,
0.027408302,
-0.0012068613,
0.020050911,
-0.008779011,
-0.0060469396,
0.025899094,
-0.04700106,
0.0035271007,
0.008037882,
-0.007283278,
-0.007950294,
0.0024036164,
-0.011420125,
0.009675103,
0.03646355,
0.029645164,
0.02002396,
-0.004904927,
0.025063638,
-0.040721674,
0.0010931654,
0.014741731,
-0.028405456,
0.014876482,
-0.0027202806,
-0.028782759,
-0.012471181,
0.010025456,
-0.023567906,
-0.004962196,
-0.013205573,
0.024174282,
-0.0050598904,
-0.00028171326,
0.004436668,
-0.026249444,
-0.010456658,
-0.020509062,
0.07729302,
0.025818242,
0.0022099123,
-0.010921548,
0.0003160326,
0.000033371864,
-0.015442435,
-0.0050430465,
-0.0082265325,
0.010988923,
-0.03263663,
0.0036012137,
-0.017086394,
-0.026559372,
0.016547391,
0.009654891,
-0.009365177,
0.031612523,
-0.0024844669,
-0.0138928015,
-0.019431056,
0.019875735,
0.018865105,
-0.0068520755,
0.0079772435,
-0.02156012,
0.012127567,
-0.018204825,
-0.034954343,
0.0065286737,
-0.011346012,
-0.0015041551,
0.01704597,
0.0006409082,
-0.0032929713,
0.0049689338,
-0.017787099,
-0.028001204,
0.001371931,
-0.016951643,
-0.012794583,
0.0108945975,
-0.00009379915,
0.023945207,
-0.026842348,
0.019188507,
0.005777438,
-0.035762846,
-0.010470132,
-0.012181467,
-0.034118887,
-0.020226086,
-0.0062086405,
0.020212611,
-0.023567906,
-0.017140295,
-0.01936368,
0.022516849,
0.018541703,
-0.031801175,
0.018487802,
0.02448421,
0.016170088,
0.0008489297,
-0.018757304,
-0.16935474,
0.0006876499,
0.025858667,
-0.024282083,
0.018258726,
0.032124575,
-0.01808355,
-0.0047095385,
-0.01887858,
0.018097024,
0.020805515,
0.004800495,
-0.03985927,
-0.023190603,
0.000057848072,
-0.017598446,
-0.014148828,
0.051420882,
0.008819436,
-0.008987875,
0.01936368,
-0.021923946,
0.01696512,
-0.017854473,
-0.0034967817,
0.014162303,
0.019646658,
-0.018177874,
-0.01055772,
-0.022193447,
-0.0058650263,
-0.005952614,
0.007869443,
-0.011083249,
0.022813302,
0.020010484,
0.004857764,
-0.020589914,
0.00037224893,
0.01991616,
0.033741586,
0.01917503,
-0.004483831,
0.023015426,
-0.02360833,
0.057296015,
0.0018679822,
-0.009095675,
0.016601292,
-0.0054270863,
0.025750866,
-0.012242105,
0.019700559,
0.0018326101,
0.022961527,
-0.000013632985,
0.021681394,
0.020697715,
-0.027893404,
0.0122690555,
-0.010955235,
-0.007539304,
0.024201233,
-0.001433411,
0.0050868406,
-0.025454415,
-0.0043760305,
0.033499036,
-0.018662978,
0.001797238,
-0.00722264,
-0.0067206933,
0.01731547,
-0.02100764,
0.0024659387,
0.007983982,
-0.012599194,
0.0023429785,
0.014836057,
0.004369293,
0.0032929713,
0.015954487,
-0.034873493,
-0.015334634,
-0.013293161,
0.0008266116,
0.0108541725,
0.017935324,
0.014903432,
-0.0015235256,
0.019525383,
-0.0079772435,
0.016830368,
-0.0025013105,
0.015806261,
0.020589914,
-0.02363528,
-0.025131013,
-0.03409194,
-0.013097772,
0.022611175,
-0.018555177,
-0.007505616,
-0.015563711,
0.02732745,
-0.00995808,
-0.005386661,
0.00008700898,
0.043012436,
-0.017881423,
0.023028903,
0.0012506553,
0.010564459,
0.0097290035,
-0.014229679,
0.0019235668,
0.01625094,
-0.008711635,
-0.0038067084,
-0.027866453,
0.053522997,
-0.007896394,
0.010881122,
0.009533615,
-0.007727955,
-0.0019740984,
-0.13593654,
-0.020158712,
0.0016060604,
-0.0038538713,
-0.017854473,
0.014121878,
-0.017288521,
0.039347216,
-0.012450969,
0.027111849,
-0.012821533,
0.013326849,
-0.012996709,
0.007829018,
0.0063265474,
0.018393476,
-0.009371914,
-0.010881122,
0.015631085,
0.03465789,
0.0009280957,
-0.0067307996,
-0.012134304,
-0.020401262,
0.024834562,
-0.01895943,
-0.033579886,
0.019633183,
0.008442134,
0.0062490655,
0.018123975,
-0.018716877,
0.025629591,
0.007909869,
-0.018999854,
-0.021870045,
-0.008516247,
-0.025939519,
0.050073378,
-0.014135353,
-0.0073641283,
-0.0053529735,
-0.0013264526,
-0.026411146,
-0.00722264,
-0.025238814,
-0.008960924,
0.0044501433,
0.018460851,
-0.012167992,
-0.02156012,
-0.042850737,
-0.033364285,
-0.0051474785,
0.0060772584,
0.004874608,
0.02448421,
0.03945502,
-0.026060794,
0.0024693073,
-0.0035911072,
0.012120829,
-0.016762992,
-0.00073186494,
0.01914808,
-0.005588787,
0.0072091646,
-0.023985632,
0.015590661,
-0.024133857,
-0.020360837,
0.00990418,
-0.019714033,
-0.0031851707,
-0.031154372,
0.0025232076,
-0.011885015,
-0.013522237,
0.009216951,
-0.023621805,
-0.012909121,
-0.019080706,
0.01179069,
-0.00042657033,
0.041072026,
0.002380035,
-0.016938169,
-0.01912113,
-0.0055146744,
-0.015967963,
-0.01239033,
0.039562818,
0.0062221154,
-0.017544547,
-0.01997006,
-0.00061522133,
-0.0017366002,
-0.0152268335,
0.005706694,
0.0033502404,
0.0035843698,
0.009190001,
-0.06268605,
0.011420125,
-0.011096723,
-0.005255279,
0.025858667,
-0.026801923,
-0.008583622,
-0.014297054,
-0.0011706471,
0.018433902,
-0.02459201,
0.016237464,
-0.020064386,
-0.001446044,
-0.0148091065,
-0.01463393,
0.043093286,
-0.030318918,
0.007215902,
0.024578536,
-0.009843541,
-0.011029349,
0.035116043,
0.0027068055,
0.0040256786,
-0.0060031456,
-0.02174877,
0.035897598,
-0.039239418,
0.0082265325,
0.0012691836,
-0.031774227,
-0.019511908,
-0.011952391,
-0.012410544,
-0.024955837,
-0.0000348457,
0.023231028,
0.026330296,
0.0024659387,
0.01622399,
-0.03985927,
0.018231776,
0.018487802,
0.0065320423,
-0.0002066529,
-0.044467743,
-0.00057016406,
0.00525191,
-0.029941615,
0.04374009,
0.005339498,
0.019633183,
-0.035574198,
0.0035911072,
-0.0005251068,
-0.0043726615,
-0.021816146,
0.004362555,
-0.0129764965,
0.0022941313,
0.021101967,
-0.0021762245,
0.0111843115,
0.00998503,
-0.0015580555,
-0.021169342,
-0.0065253046,
-0.009432552,
-0.019687083,
-0.01326621,
0.008031144,
0.016762992,
0.0018309257,
-0.00037372275,
-0.00019602022,
-0.021438843,
0.0057707005,
-0.031154372,
0.03988622,
0.0026495366,
0.00085229846,
0.003375506,
-0.011500976,
0.047944315,
0.0034075093,
-0.024632435,
-0.007060939,
0.001884826,
0.005080103,
-0.0053361296,
0.0102680065,
0.016911218,
0.022004796,
0.009654891,
0.02902531,
0.000023884042,
0.0051171593,
-0.022449473,
0.026936673,
0.002883666,
0.006639843,
-0.016035339,
-0.021196293,
-0.010928285,
0.031208271,
-0.021277143,
-0.022395574,
-0.008044619,
0.0008834596,
0.006518567,
-0.00170965,
0.010207369,
0.009237164,
-0.025750866,
0.00949319,
-0.019606233,
-0.008341071,
-0.0102680065,
0.030211117,
0.0060873646,
0.011905228,
0.006168215,
0.029806864,
-0.018851629,
0.00090451434,
0.0121006165,
-0.015199884,
0.008812699,
-0.0030251541,
0.018528227,
-0.008024407,
-0.044359945,
-0.0016869109,
-0.007465191,
-0.01269352,
0.014216203,
-0.007316965,
-0.022961527,
0.07519092,
-0.0069194506,
-0.032394078,
0.018326102,
-0.012700258,
0.029968565,
-0.0015850057,
0.009088937,
-0.020428212,
-0.018070074,
0.021357993,
-0.016924694,
0.016722567,
-0.046839356,
-0.026828872,
0.019565808,
-0.02544094,
-0.0025299452,
0.0026663803,
-0.0058886074,
0.00042678087,
-0.010732897,
0.0011815956,
0.023891307,
-0.035035193,
-0.014189254,
0.011164099,
0.0075797294,
-0.012781108,
-0.009365177,
0.031127421,
-0.007626892,
-0.04883367,
-0.0050834715,
0.0129360715,
-0.014943858,
-0.023257978,
-0.00943929,
0.0047095385,
0.013468336,
-0.0057033254,
0.013299898,
-0.020913316,
-0.030561468,
0.03988622,
-0.01991616,
-0.015981438,
-0.0057033254,
0.003222227
] |
Plants, compared to animals, exhibit an amazing adaptability and plasticity in their development. This is largely dependent on the ability of plants to form new organs, such as lateral roots, leaves, and flowers during postembryonic development. Organ primordia develop from founder cell populations into organs by coordinated cell division and differentiation. Here, we show that organ formation in Arabidopsis involves dynamic gradients of the signaling molecule auxin with maxima at the primordia tips. These gradients are mediated by cellular efflux requiring asymmetrically localized PIN proteins, which represent a functionally redundant network for auxin distribution in both aerial and underground | [
-0.0031295256,
-0.0091597475,
-0.008916102,
-0.018161455,
-0.023706032,
0.017819034,
-0.013591459,
0.010107989,
-0.024259174,
-0.012985638,
0.00782299,
0.005873828,
-0.011451331,
0.02154615,
-0.01434215,
0.020532059,
0.040669017,
0.004158433,
-0.022678772,
0.031634383,
-0.006433554,
0.011984716,
0.018016584,
-0.008672457,
0.0061701536,
0.023877243,
0.015817191,
-0.027841419,
0.01129329,
-0.02768338,
0.00034159736,
0.019952578,
-0.008639532,
-0.008165412,
0.0032727495,
-0.005893583,
0.015132351,
-0.015171861,
0.0076978756,
-0.00007865999,
0.0025714461,
0.0072830203,
-0.019043846,
-0.024930844,
-0.02839456,
0.006338071,
-0.029685222,
-0.020663759,
-0.016594224,
0.03605951,
0.010601865,
0.02158566,
-0.0066607366,
-0.0058968756,
-0.027235597,
-0.026642947,
-0.0021318968,
0.023324102,
0.008863422,
0.00087992183,
-0.0027130237,
0.008000786,
-0.019241396,
0.011596201,
-0.033662565,
0.025576176,
-0.0039839307,
0.013216114,
0.0040234406,
-0.01436849,
0.047859848,
0.023982603,
0.008988538,
-0.018806785,
0.0136309685,
-0.005722373,
-0.038746193,
0.0049025393,
-0.02278413,
0.0113788955,
-0.011872771,
-0.027920438,
0.0011087509,
0.033609886,
0.0032480557,
-0.017042004,
0.0148689505,
0.015343071,
-0.0007971977,
-0.0026438811,
0.029790582,
0.03629657,
0.019096527,
0.013130508,
-0.004672064,
-0.016449353,
0.0027163164,
0.033504527,
-0.00016853507,
-0.046332125,
-0.023376781,
0.02129592,
0.005225205,
-0.00361517,
-0.012169097,
0.017516125,
0.025444476,
0.013696819,
0.037929654,
-0.02976424,
-0.02989594,
0.017937565,
0.0070393747,
-0.0290794,
0.011773996,
-0.023785053,
0.032898705,
0.01084551,
-0.004286841,
-0.006782559,
0.02067693,
0.016752264,
0.022573411,
-0.030106662,
0.024944015,
0.011431576,
0.016515203,
0.025154734,
-0.033399165,
0.010114574,
0.02163834,
0.012880278,
-0.011773996,
0.019623328,
-0.01095087,
0.009745814,
-0.019175546,
-0.01077966,
-0.012043982,
-0.032793347,
0.0039773453,
0.00032122497,
-0.034136686,
-0.00040888792,
-0.0034801774,
0.01460555,
0.023060702,
0.007052545,
0.0112011,
0.009838004,
0.012169097,
-0.0142763,
0.014091919,
-0.042170398,
0.031028563,
0.004155141,
-0.0037238228,
0.010114574,
-0.01451336,
0.023692863,
0.020071108,
0.008356377,
-0.015619642,
0.0017960613,
0.01413143,
0.02150664,
0.0004835866,
0.0125049325,
0.006206371,
-0.006436846,
0.0055807955,
-0.0029220977,
-0.033557206,
0.022599751,
0.016765432,
-0.0051461845,
0.0030784917,
0.023798224,
-0.024022114,
-0.012406157,
0.0038785704,
0.020136958,
0.0038127203,
0.012472007,
-0.020492548,
-0.0041683107,
0.01448702,
0.0099960435,
0.0008511124,
-0.004978267,
-0.02151981,
0.031713404,
0.017292233,
0.008514416,
-0.65365434,
-0.017094683,
0.019886728,
-0.02905306,
0.052390333,
0.039957836,
-0.0055544553,
-0.0031920832,
-0.009535093,
-0.0015367765,
-0.027156578,
0.0037797953,
0.0050144843,
-0.008198337,
-0.0075991005,
-0.03724481,
0.01460555,
-0.0286843,
0.0076056854,
0.006413799,
-0.0074608154,
-0.015474771,
-0.015092841,
0.010957455,
-0.01444751,
0.010193594,
0.029843261,
-0.0049947295,
0.0053437348,
0.025615685,
-0.0044547585,
-0.004227576,
-0.00560055,
0.004092583,
0.044751722,
0.022244161,
-0.024074793,
0.016093763,
0.017858544,
0.059897244,
-0.016001573,
-0.00532398,
0.0076912907,
-0.017674165,
-0.023706032,
-0.0058310255,
0.012412742,
-0.0013285256,
-0.0049618045,
-0.023824563,
0.0009260169,
0.016633732,
-0.016870793,
-0.0014445863,
0.02847358,
0.0111220805,
0.017950734,
0.00074904476,
-0.010904775,
0.00052762387,
-0.009864343,
0.017226383,
-0.031186603,
-0.013709989,
-0.009416563,
0.0071118097,
-0.027051218,
0.008382716,
0.0059791883,
-0.013235868,
0.0069405995,
0.034136686,
-0.008916102,
-0.008606607,
-0.008494662,
0.031212943,
0.015158691,
0.0037863802,
-0.012979053,
0.039694436,
-0.0066640293,
-0.0018569726,
-0.023653353,
0.0076188557,
0.02123007,
0.0013853213,
-0.014934801,
0.0018684963,
-0.0027377175,
-0.006291976,
0.021612,
0.025431305,
-0.027367298,
-0.055524796,
-0.030291041,
0.026445396,
-0.023758713,
0.011760826,
0.0054787276,
-0.02151981,
-0.016264973,
-0.02271828,
0.0005082804,
0.014921631,
0.017055174,
0.0052680075,
-0.027288279,
0.016594224,
0.04264452,
-0.014776761,
-0.004392201,
0.006338071,
-0.016923474,
0.003060383,
-0.0034538372,
-0.017423933,
0.0034307898,
0.0120703215,
-0.0074871555,
-0.011115495,
0.0068813344,
-0.017581975,
-0.0077308007,
-0.010555769,
0.010312124,
0.011635711,
-0.019043846,
-0.027578019,
-0.015553792,
0.020505719,
-0.006644274,
-0.015685491,
0.023745542,
-0.007941521,
0.008382716,
0.006367704,
0.010292369,
0.013426834,
0.011497426,
-0.008995122,
-0.0076188557,
-0.012946128,
0.006361119,
-0.020215979,
-0.023363613,
-0.025944935,
-0.01071381,
0.019820878,
-0.0044547585,
0.0041979435,
-0.0041748956,
-0.0004646547,
-0.013301718,
0.001382852,
0.010522844,
0.0012289273,
-0.002441392,
-0.025997616,
-0.00092437066,
-0.00730936,
-0.0054326328,
0.0050276546,
-0.031660724,
0.01411826,
-0.01142499,
-0.0061372286,
-0.016199123,
0.0032019606,
0.020439869,
-0.02976424,
-0.002454562,
-0.02278413,
-0.010252859,
0.0095943585,
-0.0224022,
0.00089309184,
-0.011892526,
-0.0035394423,
-0.02145396,
0.0024562085,
0.0070722997,
0.0037995502,
-0.008823913,
-0.012043982,
0.0056235977,
0.0065915943,
0.02823652,
0.032872364,
-0.0015013821,
0.031529024,
0.006186616,
0.030185683,
-0.0123929875,
0.0111220805,
-0.008797572,
-0.022283671,
0.016804943,
0.003009349,
0.001624851,
0.029000381,
0.016897133,
-0.015777681,
-0.0043098885,
-0.012511517,
-0.0027689964,
-0.009021463,
-0.017621484,
-0.025497155,
-0.005952848,
0.014974311,
0.011984716,
-0.0015639396,
-0.011161591,
-0.024496233,
0.010957455,
0.020321338,
0.010200179,
-0.009844589,
-0.03411035,
0.0073488704,
-0.007717631,
-0.0034867623,
0.005913338,
-0.004319766,
-0.015277221,
0.019860387,
0.0042703785,
-0.00030023526,
-0.009225598,
-0.00712498,
0.0038588154,
0.0053536124,
0.0021417742,
0.0033517696,
0.016594224,
0.021862231,
0.0040366105,
-0.009824834,
0.033820607,
0.0009778738,
0.013143678,
0.027077558,
-0.014710911,
0.0069274297,
0.01460555,
-0.010621619,
0.042223077,
0.015106011,
-0.02989594,
-0.009251938,
-0.018121945,
0.0033369535,
0.003476885,
-0.012313967,
0.011773996,
-0.0024809022,
0.015277221,
0.030501762,
0.049466588,
0.013657309,
-0.0001148261,
-0.0024364535,
-0.0050474093,
-0.009396808,
-0.009238767,
-0.004145263,
0.0058507808,
-0.003687605,
-0.020597909,
-0.014974311,
-0.0061306437,
0.011352556,
0.012873692,
-0.027525337,
-0.021045689,
0.008244432,
-0.011049645,
-0.012195437,
-0.012827598,
0.0075793457,
0.0039773453,
0.0015186677,
0.024970355,
0.03561173,
-0.012768333,
-0.012050566,
-0.0063775815,
-0.0038094278,
-0.004458051,
0.021019349,
-0.02223099,
-0.009462658,
-0.0068945047,
-0.0064434316,
0.00042308684,
-0.016146442,
-0.0119583765,
0.0031624506,
0.038772535,
-0.01417094,
0.004540364,
-0.00350981,
-0.0014956202,
-0.009521923,
0.054629236,
-0.0045436565,
-0.004774132,
-0.01571183,
-0.01457921,
-0.020518888,
-0.026998537,
-0.0148689505,
0.00087004434,
-0.015132351,
-0.0074674003,
0.005096797,
0.02116422,
0.02133543,
0.038983256,
0.020071108,
-0.012116416,
-0.0047148666,
-0.0005815386,
0.012965883,
0.046305783,
0.020374019,
-0.006160276,
0.0292111,
-0.025826406,
-0.018411685,
-0.009653623,
-0.008968783,
0.017279064,
-0.012570783,
-0.003875278,
-0.013446589,
0.0127946725,
-0.004438296,
0.016423013,
0.008685627,
-0.018187795,
-0.0068154843,
-0.01430264,
0.009581189,
0.019926237,
-0.020374019,
0.004919002,
0.02897404,
0.0064533087,
0.017792694,
0.008494662,
0.010107989,
0.0019541015,
0.01434215,
0.00028891728,
0.017344914,
0.0020545227,
-0.00048317504,
0.009462658,
-0.016541542,
0.009818248,
0.01488212,
-0.005860658,
0.000048461552,
0.025694706,
0.023429463,
-0.0056631076,
-0.017700505,
-0.0030192267,
-0.017832205,
-0.015092841,
0.016923474,
-0.0048268116,
-0.027103897,
0.0033287222,
-0.012313967,
-0.0000025143931,
-0.031581704,
0.041116796,
0.01418411,
0.010891605,
-0.01472408,
-0.009251938,
-0.012965883,
0.0054458026,
-0.024114303,
0.023969432,
-0.03129196,
-0.00082518393,
-0.008264187,
-0.016804943,
0.026932687,
-0.013591459,
-0.004214406,
-0.013426834,
-0.023850903,
-0.016646903,
-0.007869086,
0.039957836,
0.019043846,
0.0037567478,
0.002591201,
-0.00044078406,
0.009647039,
0.009561433,
-0.02196759,
0.008540757,
-0.022929002,
-0.025839576,
0.02194125,
0.004267086,
-0.013815349,
0.0066541517,
0.0012684374,
-0.0101409145,
-0.029132081,
0.01459238,
-0.008672457,
-0.013064658,
0.01084551,
0.037271153,
0.013137093,
-0.0054886052,
-0.0074674003,
-0.023732373,
-0.010878435,
-0.01439483,
-0.03632291,
-0.0023837732,
-0.0070788846,
0.011793751,
-0.0043757386,
-0.015290392,
-0.015329901,
0.0072830203,
-0.015869873,
0.0050671645,
0.005610428,
0.013196358,
0.011181345,
0.008771232,
0.015408921,
-0.008382716,
0.007743971,
-0.0025862623,
0.007223755,
0.030264702,
0.008672457,
-0.026880007,
0.010292369,
-0.011576446,
-0.0067759743,
-0.032925047,
0.0045074387,
0.017055174,
0.02220465,
0.030475423,
-0.004059658,
-0.0068023144,
0.008606607,
0.013947049,
0.019965747,
-0.0057783453,
-0.015804023,
0.006466479,
0.013868029,
0.012774917,
-0.026748307,
0.011530351,
-0.030317383,
-0.012109832,
0.02153298,
0.010489919,
0.0019310539,
-0.020571569,
0.013578289,
-0.007974446,
0.0031394032,
-0.018767277,
-0.03540101,
-0.022244161,
-0.015250881,
0.018872635,
0.012294212,
0.014895291,
-0.0053799525,
0.033030406,
0.024298683,
0.0028858802,
0.0036118776,
0.010200179,
-0.0031887908,
-0.02203344,
0.034189366,
0.00550836,
0.019346757,
0.0051428922,
-0.0062557585,
0.013301718,
0.0430923,
-0.016581053,
-0.023929924,
0.0000741328,
-0.013453173,
-0.016080592,
-0.01037139,
-0.013894369,
-0.0016240278,
-0.015198201,
0.009469243,
0.00782299,
0.001944224,
0.006058208,
-0.040906075,
0.026116146,
-0.023798224,
0.02902672,
0.0032266544,
0.008494662,
-0.015962062,
-0.012248117,
-0.009745814,
-0.0062886835,
0.0064829416,
-0.02849992,
0.00044531125,
0.020308169,
-0.0077044605,
0.014908461,
0.02902672,
-0.011793751,
-0.020242319,
0.0027031463,
-0.019728687,
0.006367704,
0.0035460275,
-0.02220465,
-0.030317383,
-0.0042440384,
-0.0036645576,
-0.019504797,
0.015843531,
-0.02109837,
-0.006608057,
0.040405616,
-0.003960883,
0.042486478,
-0.0041617258,
0.008962197,
0.018846296,
0.00047453222,
-0.016936643,
-0.0009795201,
-0.026998537,
0.0024562085,
0.019728687,
0.001116159,
-0.00048523286,
-0.02198076,
0.025444476,
0.03627023,
-0.009844589,
-0.009047803,
0.0012643217,
0.014934801,
-0.000101141624,
0.0052153273,
0.0060055284,
-0.02931646,
0.0019524553,
-0.008777817,
0.0145001905,
-0.008547341,
-0.011615956,
-0.03516395,
0.0073949653,
0.0014947971,
0.02233635,
-0.013453173,
0.017173704,
0.020281829,
-0.014012899,
-0.012439082,
0.010358219,
0.004082706,
0.0049980218,
0.0052680075,
0.026313696,
0.027894098,
0.025773726,
-0.016001573,
-0.008810742,
-0.010615035,
0.040115874,
-0.015962062,
-0.010509674,
-0.011984716,
0.027709719,
0.011767412,
-0.023982603,
-0.0060845483,
-0.006473064,
-0.016976153,
0.0037402853,
0.019478457,
0.02184906,
0.0064170915,
-0.023416292,
-0.018187795,
-0.0052087423,
-0.02094033,
-0.020136958,
-0.004533779,
-0.018279985,
-0.015580132,
0.02923744,
-0.002113788,
0.008277357,
-0.02823652,
-0.024272343,
-0.026774647,
0.032319225,
-0.003967468,
0.021862231,
0.015935723,
0.0066014715,
-0.029974962,
0.008672457,
-0.0071118097,
-0.016409842,
0.016370332,
-0.03561173,
-0.026155656,
0.031028563,
-0.0010881728,
0.0014141307,
-0.011780581,
0.013242453,
-0.008883177,
0.007157905,
0.012669558,
0.0009128469,
-0.022770962,
-0.010694055,
-0.011108911,
-0.017977076,
0.04382982,
-0.032951385,
-0.0020693392,
0.004685234,
-0.018069265,
0.010127744,
-0.024008943,
-0.02204661,
-0.022863152,
0.018517045,
-0.02090082,
0.0010544246,
-0.0017730137,
-0.0148031,
-0.025760556,
0.0062886835,
-0.0020923866,
-0.017595144,
-0.002441392,
0.010786245,
0.010410899,
0.0019178839,
0.0034538372,
-0.0026998539,
-0.0071052248,
-0.02158566,
-0.023034362,
0.00354932,
-0.023416292,
0.046174083,
0.009647039,
-0.013281964,
-0.00744106,
-0.011253781,
-0.04367178,
-0.038219392,
0.0015310146,
0.011352556,
-0.010549185,
-0.0022899369,
0.009508753,
0.003132818,
-0.004280256,
0.015790852,
0.006473064,
-0.0039575906,
0.010147499,
-0.0048926617,
0.020071108,
-0.02242854,
-0.029553521,
-0.039352015,
0.018266816,
-0.012313967,
0.004500854,
0.004991437,
-0.011727901,
0.020518888,
-0.01071381,
0.032450926,
0.008171996,
0.023982603,
0.016646903,
-0.039062273,
-0.0075266655,
0.019083356,
-0.006015406,
-0.0085802665,
0.00542934,
-0.0037271152,
0.008823913,
0.0031871444,
-0.018675085,
-0.02810482,
0.007236925,
-0.0078888405,
0.027867759,
-0.019201886,
-0.002342617,
0.016620563,
0.025628855,
0.007052545,
-0.016278142,
-0.023218742,
-0.010298954,
0.00523179,
0.0042736707,
0.006713417,
0.013696819,
-0.011457915,
-0.0074213054,
-0.03721847,
-0.008060051,
-0.0012807843,
0.018582895,
-0.00028829993,
0.027867759,
0.010944285,
-0.0059232158,
-0.0037271152,
0.016581053,
-0.013130508,
-0.018767277,
-0.0125049325,
0.006446724,
0.007934936,
-0.010127744,
-0.023179231,
-0.01059528,
0.0027936902,
-0.0063808737,
-0.00087416,
-0.023706032,
0.008395887,
0.17268528,
-0.01134597,
0.01473725,
0.007263265,
-0.0028611864,
-0.004593044,
0.008981952,
0.010213349,
-0.017371254,
-0.00725668,
-0.010200179,
-0.0010972271,
-0.024917675,
-0.0017203336,
0.025655195,
-0.031081242,
-0.0062491735,
0.0045469487,
0.0035229798,
0.004184773,
0.018596066,
-0.025879085,
0.0065224515,
-0.000013247186,
0.053470273,
0.0024660858,
-0.026326867,
0.015988402,
0.011405236,
0.009357298,
-0.0047247442,
-0.011978132,
0.0047477917,
0.0014602258,
0.027130237,
-0.007921766,
0.002113788,
0.016607393,
0.021309089,
0.0085802665,
0.01488212,
0.0009153163,
0.032345563,
-0.013275378,
-0.0053667827,
0.039009593,
0.0026586975,
-0.016594224,
-0.006571839,
0.0023722495,
-0.03769259,
0.016883964,
0.0012437436,
0.003648095,
0.004431711,
-0.0015441846,
-0.00075151416,
0.009660209,
-0.0022092706,
0.02100618,
-0.013196358,
0.03579611,
-0.02794678,
0.014697741,
-0.0067891446,
0.0039049105,
-0.02126958,
-0.0029533766,
-0.0022207943,
-0.017463444,
-0.022257332,
-0.01390754,
-0.01443434,
0.008659287,
-0.019965747,
-0.02897404,
0.01074015,
0.011029891,
0.018451195,
0.02142762,
0.01031871,
-0.0055478704,
-0.031818762,
-0.0016832929,
-0.009653623,
-0.025246926,
0.032055825,
0.022507561,
-0.017186875,
-0.011648881,
0.008527587,
-0.038877893,
-0.015540621,
-0.01447385,
0.0017055174,
-0.0065224515,
0.016607393,
0.017819034,
-0.02074278,
-0.00017573743,
-0.015527451,
0.054155115,
0.01397339,
-0.003941128,
-0.024180153,
0.030422742,
0.0053536124,
0.02876332,
0.0011062815,
-0.01052943,
-0.006446724,
0.00715132,
0.005383245,
0.0023278007,
0.0032645182,
0.019122867,
0.023350442,
-0.032108504,
0.0129066175,
-0.014908461,
-0.007684706,
-0.0110694,
-0.0038785704,
0.023732373,
0.0011367372,
-0.0038686928,
-0.026972197,
0.025707876,
-0.004807057,
-0.024838654,
-0.0019656252,
-0.013268793,
0.006505989,
0.025589345,
-0.0036908977,
-0.011714731,
0.00019487512,
-0.012616877,
-0.029132081,
0.01101672,
-0.015553792,
0.0007453407,
0.025642026,
-0.00012727588,
0.028025798,
-0.012741992,
0.011773996,
0.019886728,
-0.017239554,
-0.02191491,
-0.0013919063,
-0.0005333857,
-0.007836161,
-0.009074142,
0.015132351,
-0.017568804,
-0.016567882,
-0.017476615,
0.038877893,
-0.009712889,
-0.010252859,
0.0042703785,
0.0042703785,
0.0071118097,
0.022020271,
-0.0030537979,
-0.16562615,
0.0129066175,
0.026642947,
-0.010838925,
0.025707876,
0.00048111723,
-0.006644274,
0.009462658,
0.0052350825,
0.018714596,
0.041327517,
0.009936779,
-0.016120102,
-0.031028563,
0.017766355,
-0.0014849196,
0.0023508482,
0.039404694,
0.018187795,
0.017805865,
0.005607135,
-0.016791774,
0.032319225,
0.0014034301,
-0.0006408037,
0.012366647,
0.013143678,
-0.0074213054,
-0.0046292613,
-0.04161726,
-0.0106743,
0.00730936,
0.0041716034,
-0.0060845483,
0.0026504663,
-0.0025401672,
0.0017763062,
-0.033399165,
-0.013723159,
0.015171861,
0.0041979435,
0.013453173,
-0.027130237,
-0.006446724,
-0.011108911,
0.024680614,
-0.010470165,
-0.0065883016,
0.014026069,
-0.023113381,
0.030133002,
-0.01424996,
-0.0145001905,
0.013604629,
0.027235597,
0.0016108579,
0.00026278303,
0.024667444,
-0.004849859,
-0.004286841,
0.010121159,
0.008771232,
0.020189637,
0.016541542,
-0.012373232,
-0.020057937,
0.0022175019,
0.011925451,
-0.037192132,
0.0024825484,
0.009456073,
0.001807585,
0.016936643,
-0.031739745,
0.012768333,
0.012583952,
-0.015672322,
-0.0055610402,
-0.02090082,
0.01436849,
-0.009469243,
0.025905427,
-0.008922688,
0.0013359337,
-0.032819685,
-0.0073883804,
0.0019722101,
0.00695377,
-0.0037073602,
0.0021253116,
0.018095605,
-0.024166983,
-0.0155933015,
-0.011194516,
0.017502954,
0.028447239,
0.0021022642,
-0.016304482,
-0.00009059532,
-0.0005317395,
0.032898705,
0.00064697716,
-0.02100618,
0.010259444,
0.015303561,
0.0074344752,
-0.008013956,
-0.016159613,
0.066745654,
-0.013413664,
-0.009146578,
-0.0117015615,
-0.0073225303,
0.025088884,
-0.01452653,
0.031160263,
0.032556284,
0.003287566,
0.0064829416,
-0.018135116,
0.04525218,
-0.0011754241,
-0.0108652655,
0.025892256,
0.005775053,
-0.016436182,
-0.13886467,
-0.0292111,
-0.002192808,
0.038482793,
0.0011046353,
0.0019738565,
-0.013209528,
0.010252859,
-0.018872635,
0.033241127,
-0.0040991683,
-0.03605951,
-0.009870929,
-0.015764512,
0.019373097,
0.027841419,
-0.01072698,
-0.011642296,
0.00061693304,
0.023521652,
-0.0040036854,
-0.006538914,
-0.011319631,
-0.01571183,
0.012979053,
0.01405241,
-0.034347408,
0.007809821,
0.020518888,
0.0047938866,
0.00177466,
-0.017674165,
0.02797312,
-0.013459759,
0.019228227,
0.0075134956,
0.002824969,
0.0019425777,
0.015514282,
-0.0062162485,
0.0023623721,
-0.0026010787,
0.033899628,
-0.03490055,
0.011332801,
-0.021374939,
0.007092055,
0.0020199516,
0.004461344,
-0.029711561,
-0.05125771,
-0.02823652,
-0.024259174,
0.0047905943,
0.004774132,
-0.030817842,
0.006519159,
0.0069142594,
-0.012379817,
-0.0059034606,
-0.007743971,
-0.0025879086,
-0.014408,
-0.0041617258,
0.027419979,
-0.020861309,
-0.025931766,
-0.025431305,
0.02905306,
-0.02146713,
-0.010213349,
-0.012149341,
0.0033007357,
0.00723034,
-0.015329901,
0.006028576,
-0.032319225,
-0.0059034606,
-0.0004914063,
-0.02852626,
0.0039510056,
-0.02976424,
0.040642675,
-0.023916753,
0.022994852,
0.007842746,
0.006341364,
-0.0075991005,
0.023008022,
-0.029711561,
-0.016462523,
-0.005775053,
0.006054916,
-0.025589345,
0.000055663906,
0.015356242,
0.027498998,
0.015000651,
0.011859601,
0.012524688,
-0.018306326,
-0.0074213054,
-0.038219392,
0.024008943,
-0.0026224798,
0.012695897,
0.0014519945,
0.020453038,
0.013031733,
-0.011438161,
0.0013219406,
0.018754106,
-0.020821799,
-0.009838004,
-0.017595144,
-0.02178321,
-0.026181996,
-0.026998537,
0.03561173,
0.0034209122,
0.0074937404,
0.0062853913,
-0.0005873005,
-0.0063183163,
0.023798224,
0.0105755245,
-0.016357163,
-0.0212169,
-0.02892136,
-0.0142763,
-0.021730531,
0.004500854,
0.0085802665,
-0.032925047,
-0.0142763,
0.0058046854,
-0.010799415,
-0.009890684,
0.0015515927,
0.02823652,
0.012735408,
0.033530865,
-0.006058208,
-0.031818762,
0.023745542,
-0.0221388,
-0.0137758395,
-0.0129066175,
-0.026208336,
0.006068086,
-0.0034011572,
-0.010358219,
0.04356642,
0.010812585,
-0.008659287,
-0.023482142,
-0.015843531,
-0.032240205,
0.0048992466,
-0.012208607,
0.009258523,
-0.02910574,
0.030923203,
0.020861309,
0.019412607,
-0.011951791,
-0.010628205,
-0.026853668,
-0.01452653,
0.0011392066,
-0.009298033,
-0.02936914,
-0.013565118,
-0.015474771,
0.0048663216,
0.005610428,
0.01442117,
0.017819034,
-0.015106011,
0.00075274886,
-0.02123007,
0.04472538,
0.017437104,
0.006048331,
-0.007263265,
0.017977076,
0.030765163,
-0.010970625,
-0.024496233,
0.004704989,
-0.024667444,
0.009943364,
-0.0019738565,
0.018622406,
-0.0010717103,
-0.006720002,
0.0033879871,
0.009423148,
-0.0053667827,
-0.002694915,
0.002408467,
0.011036475,
0.013170018,
-0.0024907796,
0.013551949,
-0.023969432,
0.0034801774,
0.0049618045,
-0.010496505,
-0.039957836,
-0.0012560905,
0.0022224407,
-0.020821799,
0.0074542305,
0.018214134,
-0.0076188557,
-0.015975231,
0.026603436,
0.007065715,
-0.011721316,
-0.0032085457,
0.0145397,
0.034163028,
0.013031733,
-0.009785323,
-0.007783481,
-0.011609371,
0.027314618,
0.019544307,
-0.018200966,
0.019452117,
0.003967468,
0.009330958,
0.00086757494,
-0.0035789525,
-0.011174761,
-0.0021006179,
-0.017344914,
0.03555905,
0.020453038,
-0.04382982,
0.08365595,
-0.0005848311,
-0.009903854,
0.008725137,
-0.021151049,
0.03679703,
-0.008303696,
0.02826286,
0.0018536801,
-0.030975884,
0.0047148666,
-0.0010338464,
0.017173704,
-0.01108257,
-0.0069603547,
0.026010785,
-0.023468973,
0.007961276,
-0.010246274,
-0.008145656,
0.034531787,
0.005916631,
0.009403393,
0.03582245,
-0.034716167,
-0.010983795,
0.005775053,
0.01461872,
-0.0109772105,
0.0054062926,
0.008764647,
0.006180031,
-0.0578954,
-0.001148261,
-0.0030537979,
0.012307382,
-0.022836812,
-0.016041081,
0.0018915439,
0.016396673,
-0.014710911,
0.009060972,
-0.026748307,
-0.034610808,
-0.011879357,
0.0067430492,
-0.01418411,
-0.024219664,
-0.018596066
] |
The overall size and structure of a synaptic terminal is an important determinant of its function. In a large-scale mutagenesis screen, designed to identify Drosophila mutants with abnormally structured neuromuscular junctions (NMJs), we discovered mutations in Drosophila mical, a conserved gene encoding a multi-domain protein with a N-terminal monooxygenase domain. In mical mutants, synaptic boutons do not sprout normally over the muscle surface and tend to form clusters along synaptic branches and at nerve entry sites. Consistent with high expression of MICAL in somatic muscles, immunohistochemical stainings | [
-0.023517214,
0.011642185,
0.009402776,
-0.019052092,
-0.036405798,
0.02873565,
-0.010375241,
0.010888867,
-0.0031194207,
-0.007670145,
0.012970763,
0.007937231,
0.0039172526,
0.0165456,
-0.0053656776,
-0.019914985,
0.03878902,
-0.00046739948,
0.0021948942,
-0.009765739,
-0.010169791,
0.0076564485,
-0.017093467,
-0.02816039,
0.020777876,
0.037364565,
-0.018175505,
-0.036789306,
-0.03139281,
0.002948212,
0.005680701,
0.010039672,
0.011758607,
-0.025215602,
-0.016846927,
0.018819248,
0.019421903,
-0.013285787,
0.011943512,
-0.008923392,
0.018435743,
0.0049890187,
-0.015038963,
-0.0019860198,
-0.022270815,
0.012142113,
-0.009752042,
-0.0048246584,
-0.018641192,
0.017833088,
0.013566569,
0.022065364,
-0.024174655,
0.002266802,
-0.003841921,
-0.0016855487,
0.026612666,
0.010299909,
0.02013413,
-0.011861332,
-0.007663297,
0.014778726,
-0.026831811,
0.0064477157,
0.00087059574,
0.008628913,
-0.0036364705,
0.0071633677,
-0.003944646,
0.0017001014,
0.022695411,
0.028009728,
0.007964624,
-0.0029687572,
0.0297766,
0.0063758083,
-0.03320077,
0.005595097,
-0.018504225,
0.010067065,
0.03139281,
-0.010621781,
-0.0027444737,
0.0031553744,
0.006745619,
-0.009683559,
0.010251971,
-0.0113203125,
0.0023541183,
-0.0063381423,
0.012422896,
0.02795494,
0.0031587987,
-0.009505501,
-0.020613516,
-0.009279506,
-0.002509918,
-0.000397846,
0.00975889,
-0.0017822816,
-0.016901713,
0.009224719,
-0.019599961,
-0.02013413,
-0.005078047,
-0.0061635096,
-0.010402635,
-0.018586405,
0.02601001,
-0.011450431,
0.009745194,
0.023887023,
-0.020709392,
-0.02580456,
0.024092475,
-0.020408064,
0.028461717,
0.0048691723,
0.013539176,
-0.00027543184,
0.026913991,
0.024927972,
0.018517923,
-0.00473563,
0.035748355,
0.02816039,
-0.010669719,
0.009190477,
-0.025010152,
0.008019411,
0.008375525,
0.011484673,
0.024640342,
0.022558445,
-0.0044240304,
0.011484673,
-0.0053108907,
-0.00061035866,
-0.001770297,
-0.024695128,
0.0023609665,
0.034680013,
-0.041199636,
-0.00091082975,
0.008937089,
0.035803143,
0.012169507,
0.017887874,
0.025859347,
0.0024517071,
0.020695696,
-0.01720304,
-0.0053074667,
-0.004061068,
0.020599818,
0.024900578,
-0.028845225,
0.018476833,
-0.014395219,
-0.0128200995,
-0.0040884614,
0.0074783918,
0.012190052,
-0.011546308,
0.014874603,
0.026393518,
0.015942944,
-0.022791289,
0.00081195676,
-0.010032824,
-0.0018370682,
0.02601001,
-0.028763045,
0.024886882,
-0.018504225,
0.019161666,
0.011738062,
0.011114862,
-0.027763186,
-0.0026999596,
-0.009402776,
0.014669153,
0.0055197654,
0.0076975385,
-0.0042528217,
0.0059238174,
0.030817548,
-0.0113340095,
-0.01190927,
-0.020421762,
0.00014242415,
-0.00390698,
-0.008861757,
-0.012587256,
-0.6372795,
-0.005002715,
0.013559721,
-0.01480612,
-0.0023558303,
0.026270248,
0.004180914,
-0.006173782,
-0.015559438,
0.0064477157,
-0.025626503,
0.014354129,
0.0040268265,
-0.01740849,
-0.035255276,
-0.024092475,
-0.011375099,
-0.027448162,
0.023120008,
-0.0008102447,
-0.026790721,
0.0031998886,
0.0026212037,
0.019723231,
0.017518064,
-0.004156945,
-0.0008945649,
-0.0042322767,
-0.023421336,
0.014011712,
-0.0268866,
0.004838355,
-0.0127790095,
-0.003944646,
0.061142016,
0.008115288,
0.0015306049,
0.008772729,
0.005855334,
0.02381854,
-0.014230859,
0.018682282,
0.01566901,
0.009683559,
-0.03470741,
0.019545173,
0.016162092,
-0.004043947,
-0.0040336745,
-0.028352143,
0.012416048,
0.0002429022,
-0.022133848,
0.0047664475,
0.00023583985,
-0.0077728704,
0.031009302,
-0.007266093,
0.032899443,
0.025201906,
-0.0012669436,
0.007834505,
-0.009799981,
-0.027119443,
0.021613374,
-0.028324751,
-0.005721791,
-0.016107306,
-0.0016358981,
0.0012652315,
0.010827232,
0.023435034,
-0.012251687,
0.01517593,
-0.016011428,
0.040432625,
-0.016189486,
-0.016970197,
-0.01918906,
0.013237849,
0.005574552,
-0.015655315,
-0.02369527,
0.0013859336,
0.04665092,
0.0044719684,
-0.0120599335,
0.010649174,
0.008895999,
0.008067349,
0.018956216,
0.0023558303,
-0.014696546,
-0.036049683,
-0.028379537,
0.014354129,
-0.020517638,
0.020449156,
0.020257402,
-0.018148111,
-0.012498228,
-0.004081613,
0.015285504,
-0.014176072,
0.024421195,
-0.0056498838,
-0.02373636,
0.028790439,
0.028790439,
-0.024530768,
-0.0042048832,
-0.010251971,
-0.017024983,
-0.01675105,
0.009231567,
-0.02422944,
0.026626362,
-0.0148883,
-0.015723798,
-0.011594246,
-0.008265951,
-0.0046705706,
-0.006273083,
-0.003965191,
-0.000034749995,
-0.009813677,
-0.0012207173,
-0.019161666,
0.0061977515,
-0.0149841765,
-0.0042185797,
0.015107446,
0.02080527,
-0.027516646,
0.019558871,
0.011169649,
0.040898312,
0.012484531,
0.006793557,
-0.036487978,
-0.019983469,
-0.0050472296,
0.0031879041,
-0.0021555163,
-0.006868889,
-0.01886034,
-0.023887023,
-0.010642326,
0.006608652,
0.005930666,
-0.002047655,
-0.0031399657,
-0.010347848,
0.012251687,
-0.0012181492,
-0.02692769,
-0.04708921,
-0.014545882,
-0.003107436,
-0.021312047,
0.0010306757,
0.009615075,
-0.013046095,
-0.0021401076,
-0.030406646,
-0.011820242,
0.005341708,
0.02961224,
0.0018593253,
-0.025941527,
-0.0021966062,
-0.019339724,
-0.019298634,
-0.00016168512,
-0.0152992,
0.014408915,
0.001972323,
0.00076187827,
-0.006331294,
-0.015874462,
-0.003605653,
-0.017600244,
0.0013474117,
-0.0041911863,
0.04876021,
0.0030646338,
0.031064088,
-0.0034002028,
-0.00434185,
0.0219147,
-0.00018137411,
0.01521702,
-0.02754404,
0.02336655,
-0.006790133,
-0.021106595,
0.03465262,
0.003927525,
-0.023572,
0.0297766,
0.0069784625,
-0.02527039,
0.0068654646,
-0.00653332,
0.004283639,
-0.029036978,
0.005269801,
-0.02514712,
-0.009526046,
0.001513484,
0.0105806915,
0.010724506,
0.0038282243,
-0.0042939116,
0.006053936,
-0.019778017,
0.0004888006,
0.0034789587,
-0.006913403,
-0.004626056,
0.004513059,
-0.007005856,
0.022106454,
0.0007306327,
0.0055471584,
0.028297357,
0.018093325,
0.013340574,
-0.0010666295,
-0.003002999,
-0.0012866326,
0.004345274,
-0.006529896,
-0.00087316387,
0.024708824,
0.008135833,
-0.008820667,
-0.011573701,
0.04862324,
0.00274961,
0.0020459427,
0.028680865,
0.0046534496,
0.005855334,
0.023311762,
-0.0058039716,
0.03832333,
-0.019599961,
-0.007724932,
0.0069031306,
0.0044274544,
-0.006033391,
0.0050711986,
0.0016213454,
-0.009580833,
0.010361545,
0.009690407,
0.024654038,
0.044295087,
0.03221461,
0.0016059367,
-0.009361686,
-0.014093892,
-0.005019836,
0.009628772,
0.017723514,
-0.002011701,
0.014093892,
-0.0106012365,
-0.016408632,
-0.02348982,
0.03133802,
0.0038179518,
-0.02332546,
0.0039172526,
0.008656307,
0.027311197,
0.014737636,
0.022832379,
0.010656023,
-0.012717375,
-0.052759644,
0.022585839,
0.0056909737,
-0.01642233,
-0.01534029,
-0.022531051,
0.004153521,
-0.005420464,
-0.004715085,
-0.0008877166,
0.02527039,
-0.018380955,
-0.002710232,
-0.010204032,
-0.0052252864,
0.012251687,
-0.024023991,
0.012128417,
-0.020230008,
0.003684409,
0.004283639,
-0.012087327,
-0.0037426199,
0.025667593,
0.010477967,
-0.02443489,
-0.013498086,
-0.0017805694,
-0.014669153,
-0.008978179,
0.007786567,
-0.0074715433,
-0.027365983,
-0.012292777,
0.0063141733,
-0.002869456,
-0.0036535915,
0.03317338,
0.012272232,
-0.03813158,
-0.041994046,
-0.013600811,
-0.011436734,
0.02803712,
0.024708824,
-0.0121969,
0.018613799,
0.006190903,
0.008772729,
-0.011696971,
-0.0047904165,
0.0062799314,
-0.012998157,
-0.019490387,
0.017874178,
0.016436026,
0.026023706,
0.007629055,
0.017942661,
-0.013278939,
-0.014340432,
-0.0015485818,
0.0010888866,
0.0050129876,
-0.017696122,
0.019819107,
0.045582578,
0.02985878,
0.0028848648,
-0.018737068,
0.010190336,
0.008553581,
-0.031036695,
0.0057046707,
0.0018490528,
0.010436876,
0.031447597,
-0.006608652,
-0.027859064,
-0.002009989,
0.01513484,
-0.009320596,
0.014121286,
0.021805128,
-0.011409341,
0.009183629,
-0.008430311,
-0.00062961964,
-0.015682708,
-0.0012198612,
-0.008567278,
-0.018011145,
0.0001352548,
0.03287205,
-0.026146978,
0.008895999,
-0.013491238,
0.017737212,
0.010690265,
0.005040381,
0.000637752,
-0.012231142,
-0.020955933,
-0.008985028,
-0.019038396,
-0.00740306,
-0.016162092,
-0.022120152,
-0.017435884,
-0.0017634486,
-0.00019378673,
-0.026694845,
-0.027927546,
0.013176214,
-0.03878902,
-0.014901997,
-0.013203607,
0.022681715,
0.0112929195,
0.035803143,
-0.0024654039,
0.035419635,
0.055526372,
-0.020462852,
-0.009395928,
-0.0003466974,
-0.026146978,
0.0127721615,
0.012313322,
0.016983893,
-0.014011712,
-0.028927404,
0.00270852,
0.011203891,
-0.011518914,
-0.00091682206,
-0.008704245,
-0.014408915,
0.002785564,
0.04026826,
0.032899443,
0.013450148,
-0.020997023,
0.0024996456,
-0.03878902,
-0.021339439,
-0.03700845,
-0.017052377,
-0.027502948,
-0.0014869467,
0.009443866,
-0.013415906,
-0.01211472,
0.0054444335,
-0.017230432,
0.005588249,
0.026242854,
0.007786567,
0.032735083,
0.0027958364,
0.031064088,
-0.0045541488,
-0.017723514,
0.01658669,
-0.02807821,
0.026612666,
0.021339439,
-0.038679447,
0.026311338,
0.0013277227,
-0.026612666,
-0.007738629,
0.012991308,
0.010012279,
0.035200488,
-0.021339439,
-0.04900675,
-0.0059203934,
-0.018641192,
-0.018339865,
0.010258819,
-0.0055608554,
0.0034395808,
-0.013018702,
0.03172153,
-0.0036535915,
-0.008875454,
0.009026118,
-0.03229679,
-0.016778443,
0.021517497,
0.0067182253,
0.013792565,
-0.0048417794,
0.017422186,
-0.009286354,
-0.007252396,
-0.007889292,
-0.03035186,
0.010703961,
-0.013320029,
0.022257118,
0.037994612,
0.050924286,
0.009224719,
0.026708541,
0.022818683,
0.002850623,
0.010868322,
-0.0033916424,
0.019901287,
-0.023928113,
0.006930524,
0.018312471,
-0.015655315,
0.030790154,
-0.014792423,
-0.0012301338,
0.016778443,
-0.014134982,
-0.019490387,
0.008327587,
-0.04528125,
-0.009252112,
0.0030629218,
-0.00012070206,
-0.0039891605,
-0.035583995,
0.0043521225,
0.022092758,
0.0091493875,
-0.010683416,
-0.014819817,
0.028598685,
-0.010245123,
0.03862466,
-0.018668586,
0.013141972,
-0.0005350269,
-0.0017994024,
0.0035268972,
-0.00039163968,
0.0027222168,
0.010758748,
0.009731497,
0.00031909003,
0.019750625,
0.00434185,
0.010313606,
-0.01575119,
0.011991451,
-0.021681856,
-0.03292684,
-0.021188777,
-0.01525811,
-0.009478108,
-0.03848769,
0.03043404,
0.010840928,
-0.009382231,
0.020216312,
-0.019832805,
-0.020914843,
0.02625655,
-0.027859064,
0.023955507,
-0.023174796,
0.015655315,
0.013436451,
0.005324587,
-0.020490246,
-0.027763186,
0.02101072,
0.00955344,
0.04130921,
0.018490529,
-0.020462852,
0.00044899454,
0.001255815,
0.0029396517,
-0.012628347,
-0.041254424,
0.011375099,
0.0038693144,
-0.0015160522,
-0.02138053,
0.013203607,
-0.01886034,
0.011970906,
-0.019202756,
-0.0024499951,
-0.0018148111,
-0.019586263,
-0.010436876,
0.017901571,
0.008245406,
0.033721246,
0.012758465,
0.012265384,
0.0037049542,
-0.013429603,
-0.013587114,
0.020449156,
-0.0026588696,
0.04056959,
0.0049308077,
0.007546875,
0.00744415,
0.026393518,
0.0008902847,
-0.011881877,
0.00020384524,
0.040131297,
-0.012292777,
0.0018473407,
-0.00018255117,
-0.010176639,
0.0067319223,
-0.011073772,
0.0025818257,
-0.03610447,
-0.029940959,
-0.0054615545,
0.028763045,
0.0018627496,
0.0072797895,
-0.0033967786,
-0.01951778,
-0.0053862226,
-0.02170925,
-0.012963915,
-0.0016812684,
-0.042377554,
-0.012511925,
-0.0023404215,
0.0002649453,
0.024914276,
0.005095168,
-0.011258678,
0.0018867188,
0.028009728,
-0.008252255,
0.025640199,
0.009498653,
0.00030196918,
-0.02779058,
0.018463135,
-0.020682,
-0.027434466,
-0.005612218,
-0.030625794,
-0.020914843,
0.015080053,
-0.005054078,
0.03026968,
0.0070127044,
-0.020038255,
0.026653755,
-0.013929532,
0.0033163105,
0.008580975,
-0.0064477157,
0.01091626,
-0.036652338,
0.0013106018,
0.0011847635,
0.006971614,
-0.015915552,
0.0018969913,
-0.0335021,
-0.0004502786,
-0.021270957,
-0.0013893577,
-0.01886034,
0.0038350725,
0.016792139,
-0.0018661737,
-0.01931233,
-0.015545741,
-0.03051622,
0.03632362,
-0.0022650897,
-0.018627496,
-0.025174512,
-0.014792423,
-0.0021383953,
0.0019449297,
-0.036789306,
-0.006769588,
0.018682282,
-0.033145986,
-0.062347323,
-0.010354696,
-0.01992868,
0.04130921,
0.018969912,
-0.0065264716,
-0.0060847537,
0.006745619,
-0.055635948,
-0.014381522,
0.001770297,
-0.011423037,
0.014696546,
0.008293345,
-0.0036570157,
-0.0007028113,
0.012648892,
0.007190761,
-0.019832805,
-0.0029122583,
0.0058793034,
0.013456996,
0.01816181,
0.016915409,
-0.019326027,
-0.026105886,
0.0048589,
0.0021846218,
-0.014025409,
0.024996456,
-0.023229582,
0.003982312,
-0.0075605717,
0.007841354,
0.0084371595,
0.016353846,
0.016819533,
-0.007848202,
-0.013819958,
-0.00083763804,
-0.024927972,
-0.018175505,
0.012148962,
-0.0009219583,
0.0052663763,
0.008444008,
-0.019504083,
-0.008327587,
0.009710952,
-0.011929816,
0.022709109,
0.019421903,
0.004584966,
0.0003344988,
0.0042939116,
0.0039583426,
-0.026366124,
-0.002331861,
-0.013573417,
0.0030629218,
0.0019021275,
-0.0049513527,
-0.004441151,
-0.020654606,
0.011169649,
-0.03470741,
0.007026401,
-0.018134415,
-0.0070537943,
-0.028489111,
-0.01525811,
0.006293628,
-0.012518773,
-0.008711093,
0.02576347,
0.0038487692,
0.017148253,
0.00011684987,
0.010334151,
-0.02344873,
0.030214893,
0.009087753,
-0.029420486,
0.0033899304,
-0.0149567835,
-0.010984744,
-0.023352852,
-0.0014355842,
0.17783779,
-0.0012267096,
-0.0068586166,
0.02443489,
0.0070400974,
-0.0013157381,
0.028543897,
-0.010662871,
0.0027718672,
0.0030560736,
0.013128275,
0.018107021,
-0.007998866,
0.0047116606,
0.043719828,
-0.017887874,
-0.006964766,
-0.012683133,
-0.025626503,
-0.00851934,
0.0091082975,
-0.016860623,
0.01703868,
0.008800122,
0.042240586,
0.0019825955,
-0.019052092,
-0.02092854,
-0.007368818,
0.030653188,
-0.023928113,
0.0025338873,
0.005036957,
0.0142445555,
0.024503374,
0.008889151,
-0.021777734,
-0.005954635,
-0.007307183,
0.020380672,
0.0194356,
0.005119137,
0.0031194207,
0.009272657,
-0.01670996,
-0.012628347,
0.022407781,
-0.026653755,
-0.014532186,
0.0020253977,
-0.042706273,
0.017011287,
0.01935342,
0.018353561,
0.008622065,
-0.011012137,
0.0010392362,
-0.0029790297,
0.008163226,
0.028489111,
-0.029256126,
0.0134843895,
-0.013340574,
0.040870916,
-0.017052377,
0.01583337,
-0.0045438763,
0.007190761,
0.011676426,
-0.024749914,
0.008895999,
-0.00880697,
0.0015648466,
0.0030526493,
0.0031177085,
-0.004081613,
0.022092758,
0.030242287,
0.009793132,
0.006550441,
0.0018815825,
-0.0026485971,
-0.020284794,
-0.005040381,
-0.009347989,
-0.006793557,
0.03325556,
-0.0039172526,
-0.024900578,
-0.037419353,
0.006211448,
-0.028626077,
-0.014299342,
0.0029704692,
0.0008727358,
0.016162092,
0.003862466,
0.0086837,
-0.019901287,
0.003961767,
-0.034214325,
0.04900675,
0.0038179518,
0.024065081,
-0.012135265,
-0.0047459025,
0.0028780166,
0.0142719485,
-0.0035611389,
-0.0036022288,
0.013984319,
-0.02320219,
0.0044308784,
-0.01501157,
-0.0065196236,
-0.014915694,
0.012450289,
-0.035447028,
0.03246115,
-0.018476833,
0.0010657735,
-0.0038076793,
0.0037186507,
0.019490387,
0.0011907557,
0.0004481385,
-0.017942661,
0.0018644617,
-0.004222004,
-0.026872901,
0.016490811,
-0.01389529,
0.008348132,
0.016901713,
-0.016244272,
-0.028790439,
-0.0043897885,
-0.013361119,
-0.0018969913,
0.004985594,
-0.020572426,
-0.007505785,
0.018449439,
-0.0005637043,
-0.012285929,
-0.01054645,
0.011121711,
0.028763045,
-0.012381806,
-0.0020562152,
-0.009423321,
-0.025708683,
-0.003443005,
-0.010025975,
0.014833513,
-0.022339297,
-0.020545032,
-0.026201764,
-0.016312756,
-0.018312471,
-0.03717281,
-0.0057491846,
0.012210597,
0.001772009,
0.007882444,
-0.015408774,
-0.17487931,
0.016860623,
0.018723372,
-0.0045267553,
0.022585839,
0.0026468849,
0.019586263,
-0.0044651204,
-0.019832805,
-0.0018576133,
0.0056019453,
0.0031570867,
-0.028598685,
-0.02807821,
0.0004892286,
0.032515936,
-0.0028814408,
0.0033676731,
0.019462993,
0.012888583,
0.03300902,
-0.03122845,
0.01927124,
-0.021777734,
-0.00021818395,
0.020188918,
-0.00434185,
-0.014600669,
0.007670145,
-0.017997447,
-0.015778584,
-0.0105943885,
0.023681574,
-0.010649174,
0.027681006,
0.005160227,
-0.0091288425,
0.0034875192,
-0.0052013174,
0.007663297,
0.01757285,
0.010334151,
-0.011594246,
-0.007341425,
-0.021270957,
0.00992325,
0.009224719,
-0.0013653886,
0.010806687,
0.009142539,
0.024914276,
-0.0049034143,
0.00064845255,
0.019586263,
0.03440608,
0.018271381,
0.010156094,
0.015929248,
0.0007982601,
-0.0050301086,
0.006550441,
-0.027434466,
0.03651537,
0.0061806305,
0.017504368,
-0.016970197,
-0.008895999,
0.0031879041,
-0.037227597,
-0.000009510102,
-0.0065025026,
0.007930382,
0.027722096,
-0.012265384,
0.024654038,
0.01273792,
0.009656165,
0.0062182965,
-0.008827515,
0.009032966,
-0.018312471,
0.021339439,
-0.033392526,
-0.031118875,
-0.012128417,
0.005273225,
0.01918906,
0.018422045,
-0.0037254991,
0.02451707,
0.0031519502,
-0.025996314,
0.013491238,
-0.012840644,
0.045418218,
0.020024559,
-0.0029225308,
0.012244839,
-0.0058450615,
0.0028232299,
0.015655315,
-0.008005714,
-0.009875312,
0.009587682,
-0.0007905557,
0.011272375,
-0.0063963532,
0.01757285,
0.022106454,
-0.0041055824,
0.008998724,
0.0016992453,
0.0061635096,
0.049390256,
-0.010683416,
0.006310749,
0.01658669,
-0.020640908,
0.0380494,
-0.007348273,
0.06251168,
0.0003445573,
0.017750908,
0.009656165,
-0.018819248,
-0.009621923,
-0.124694645,
-0.034762193,
0.017696122,
0.009936947,
-0.029064372,
0.0074373013,
0.002848911,
0.05454021,
-0.022900863,
0.026694845,
-0.0059991493,
0.0026931113,
0.015189627,
0.0023729512,
0.001811387,
0.008793274,
0.008957634,
-0.005930666,
-0.010532753,
0.02138053,
0.0013328589,
-0.0030252559,
-0.022558445,
-0.0045062103,
0.0142171625,
0.022257118,
-0.006413474,
0.023928113,
0.0051294095,
0.009087753,
0.01935342,
-0.016299058,
0.021257259,
-0.0023078918,
-0.028105604,
-0.015805978,
0.0018593253,
-0.021243563,
0.03974779,
-0.008505643,
-0.016203182,
-0.0112997675,
0.0028026847,
-0.003360825,
-0.00819062,
0.005971756,
-0.0030115594,
0.010299909,
-0.015901854,
-0.005194469,
-0.02547584,
-0.0063929292,
-0.016216878,
-0.0077728704,
0.038652055,
-0.0024345862,
-0.015737494,
0.0064237467,
-0.024421195,
-0.010334151,
0.0029036978,
0.011546308,
-0.004365819,
-0.010512208,
0.021284653,
-0.03407736,
-0.02170925,
-0.044569023,
0.02613328,
-0.058347892,
0.0065778345,
0.02506494,
-0.022325601,
-0.010621781,
-0.032351576,
0.0120325405,
-0.020682,
-0.007889292,
0.0018781583,
-0.02072309,
-0.014710243,
-0.016107306,
0.026544182,
-0.004376092,
-0.0007186481,
0.020147828,
0.0050095636,
-0.010964199,
0.008546733,
-0.008793274,
-0.002628052,
0.0024191774,
0.012683133,
0.017230432,
-0.019641051,
-0.0020202615,
0.01575119,
0.0045952387,
0.006831223,
0.03462523,
-0.037748072,
-0.027598826,
-0.05234874,
0.013991167,
-0.0091219945,
-0.0031776316,
0.035173096,
-0.031283237,
0.005814244,
0.0036981057,
0.011244981,
0.02254475,
-0.031831104,
-0.000010225701,
0.014176072,
-0.01513484,
-0.032105036,
-0.007971472,
0.03684409,
-0.016230576,
0.018257685,
0.0314202,
-0.0069544935,
-0.030132713,
0.030050533,
0.028516505,
-0.026653755,
-0.012292777,
-0.02551693,
0.0035919563,
-0.0014150391,
-0.011696971,
-0.005992301,
-0.040432625,
-0.008039956,
0.010614933,
-0.021640766,
-0.017696122,
-0.011265526,
0.022188634,
0.0074304533,
0.029338306,
-0.019449297,
-0.039254706,
0.022873469,
0.0027033838,
0.0032358426,
-0.013573417,
-0.03952864,
-0.008676852,
0.0033317194,
-0.013991167,
0.013039247,
-0.0051841964,
-0.0049445042,
-0.028489111,
-0.02096963,
0.02001086,
0.010224578,
0.01583337,
-0.015353987,
-0.009971188,
0.018175505,
0.010745051,
0.012457138,
0.0021007296,
-0.006208024,
-0.009738345,
-0.032022856,
0.026585272,
0.0076975385,
-0.0152992,
-0.021887308,
0.00033770897,
0.018997306,
-0.0044445754,
0.00955344,
-0.00417749,
-0.018819248,
-0.014545882,
-0.006416898,
0.017627638,
0.015696405,
0.0057834266,
-0.006930524,
0.012210597,
0.023832237,
0.0031091482,
-0.001591384,
0.006666863,
-0.012272232,
0.014696546,
0.009505501,
0.018326169,
0.004879445,
0.014134982,
0.004516483,
0.039227314,
-0.014367825,
0.0012078767,
0.023900721,
0.016408632,
-0.018654888,
0.007622207,
0.007081188,
-0.030543614,
0.016518205,
0.010635478,
-0.03320077,
-0.033392526,
0.009663014,
0.0045096343,
0.0051465305,
0.0048623243,
0.018805552,
0.00541704,
0.0060265427,
0.015189627,
0.017682424,
-0.009306899,
-0.01468285,
0.004995867,
0.014860907,
0.008868606,
0.0050095636,
-0.006307325,
0.011409341,
0.022024274,
0.02572238,
-0.032981623,
0.01302555,
-0.023558304,
0.011368251,
-0.00022321321,
-0.025174512,
-0.018627496,
-0.0010897428,
-0.026229158,
0.0034909432,
0.012231142,
-0.0048452034,
0.10245123,
0.007992017,
0.009245264,
-0.015737494,
-0.03303641,
0.022010578,
-0.005420464,
0.01910688,
-0.012183204,
-0.009478108,
0.021312047,
-0.017928965,
0.027092049,
-0.026612666,
-0.023065222,
0.0105875395,
-0.019079486,
0.039227314,
0.0010597812,
-0.028927404,
0.010279364,
-0.023421336,
0.0011505218,
0.013600811,
-0.02969442,
0.013237849,
0.023051526,
0.0077317804,
0.0060470877,
-0.013128275,
0.0047869924,
-0.014299342,
-0.041281816,
0.0066394694,
0.0007584541,
-0.005054078,
-0.0065778345,
-0.004006281,
0.0004699676,
0.02080527,
-0.0074099083,
0.0030697703,
-0.010477967,
-0.009827374,
-0.007916685,
0.0032375546,
-0.01492939,
-0.020202614,
-0.05207481
] |
Type 1 diabetes (T1D) is characterized by the destruction of the insulin-producing β-cells of pancreatic islets. Genetic and environmental factors both contribute to T1D development. Viral infection with enteroviruses is a suspected trigger for T1D, but a causal role remains unproven and controversial. Studies in animals are problematic because of species-specific differences in host cell susceptibility and immune responses to candidate viral pathogens such as coxsackievirus B (CVB). In order to resolve the controversial role of viruses in human T1D, we developed a viral infection model in immunodeficient mice bearing human is | [
-0.02442237,
-0.028532283,
0.021274071,
-0.012724924,
-0.018455092,
0.00054790615,
-0.016321098,
-0.0067181275,
-0.010439443,
-0.017783279,
-0.0027597016,
0.020997442,
-0.0067576463,
0.006622625,
0.0068827877,
0.003527017,
0.029085541,
0.005815791,
0.009043126,
-0.00632953,
-0.04615749,
0.014845745,
0.017019257,
-0.00044252374,
-0.008773085,
0.0060232626,
-0.0039156144,
-0.03825381,
-0.023078745,
-0.012520746,
0.0013782041,
-0.0048739356,
-0.031825483,
0.0040144105,
0.01952209,
-0.014345178,
-0.009793976,
0.00021982109,
0.010979529,
-0.0034018755,
0.018362882,
0.030323785,
-0.003326132,
0.019469397,
-0.004679637,
0.0215507,
-0.011862106,
-0.008819189,
0.010492135,
0.003013278,
0.0041922433,
0.0140685495,
-0.013554811,
-0.01463498,
-0.023026053,
0.0013156333,
0.0015000525,
0.0027152433,
0.0089179855,
-0.039729163,
-0.008483283,
0.003872803,
-0.02456727,
-0.0051834965,
0.0005783682,
0.02493611,
0.007449218,
0.01703243,
-0.0023562845,
0.016545037,
0.014740363,
0.029190924,
0.008410833,
0.0075216684,
0.012408777,
-0.0064217397,
-0.005292172,
-0.0041428455,
0.004347024,
0.0148852635,
0.015846878,
-0.020589085,
-0.02328951,
0.038148426,
0.0036126403,
-0.012856652,
-0.0029523536,
0.018902967,
-0.0027959268,
-0.01077535,
-0.011427403,
0.0015000525,
0.009662248,
0.03849092,
0.009846668,
0.008786257,
0.0043898355,
0.029665144,
0.0002527531,
-0.0011501501,
-0.011038806,
0.008845535,
-0.01095977,
-0.020049,
-0.028769394,
0.014252969,
0.007758779,
0.0017338698,
0.0040769815,
-0.0028420314,
-0.020681296,
0.040572222,
-0.03137761,
-0.031403955,
0.02239376,
0.0264905,
0.019377189,
-0.015636113,
-0.011960902,
-0.0069486517,
0.03227336,
0.0035632423,
0.011657927,
-0.019284979,
0.01061069,
-0.0033607106,
-0.025291774,
0.0025472902,
0.008628184,
-0.010103537,
0.017835971,
0.005904707,
0.013963168,
-0.009998155,
-0.014055377,
0.00962273,
-0.05087335,
0.0026065677,
-0.013271595,
-0.017572515,
-0.00032335107,
0.028400555,
-0.007139657,
0.009431724,
0.021168688,
0.021063305,
0.0166109,
0.004004531,
-0.0055490416,
0.014411042,
-0.011776483,
-0.009234132,
0.006619332,
-0.019983137,
0.03166741,
0.034855228,
-0.017282713,
0.03071897,
-0.007659983,
-0.02211713,
0.013963168,
-0.0038958555,
-0.005799325,
0.015082856,
0.035065994,
0.023355374,
-0.0032289824,
-0.0018161997,
0.008687461,
0.001290111,
-0.02583186,
0.011974075,
-0.018982004,
0.021840502,
-0.010004741,
0.020681296,
-0.014951128,
0.016070815,
-0.022354241,
-0.0023151196,
-0.029085541,
0.024804382,
0.0070079295,
0.013963168,
-0.03029744,
-0.0064678444,
0.023039225,
-0.0018573647,
0.003219103,
-0.02945438,
0.008858708,
0.004890402,
0.021168688,
-0.03440735,
-0.63608813,
-0.02103696,
0.033485256,
0.012520746,
-0.019495742,
0.021366281,
0.012059698,
0.008753325,
-0.037568823,
0.0034216347,
-0.004514977,
0.004732328,
0.019350842,
-0.024962455,
-0.007383354,
-0.031825483,
-0.0043206783,
-0.011809414,
-0.006902547,
0.0006718128,
-0.0021257605,
0.011723791,
-0.0028552043,
0.0095832115,
0.012092629,
-0.006131938,
0.0080815125,
-0.0039189076,
0.015688805,
0.023342201,
-0.012863238,
0.009510761,
0.00830545,
-0.030323785,
0.04083568,
-0.00059812743,
-0.004831124,
0.014595462,
0.008364728,
0.03727902,
-0.020589085,
0.01218484,
0.003107134,
0.015280447,
-0.005262533,
0.023210473,
-0.006856442,
0.014108068,
0.029638799,
-0.009899359,
0.017862316,
0.011572304,
-0.035171375,
-0.015227756,
0.040440496,
-0.01439787,
0.02263087,
-0.030218402,
0.029717835,
-0.015899569,
-0.0037970594,
0.043522928,
-0.008819189,
-0.0057696863,
0.0029803459,
-0.005799325,
-0.002017085,
0.035671942,
-0.000073582436,
0.0031186603,
-0.0005713702,
0.014819399,
0.0063262368,
0.0018820637,
0.025897725,
0.028505938,
0.01538583,
0.0046532913,
-0.018889794,
0.007350422,
-0.0014481846,
0.00075620104,
-0.019890927,
-0.018059907,
0.023921805,
-0.0052164285,
0.010175987,
0.03459177,
-0.027267694,
0.017822798,
0.0053020515,
0.019561607,
-0.015925914,
-0.02456727,
-0.02771557,
0.025252257,
-0.010511894,
0.00485747,
-0.010643622,
0.030692622,
-0.015570249,
-0.0018458385,
-0.006217561,
-0.008456937,
0.032457776,
0.012118976,
-0.04244276,
0.005865189,
0.056326892,
-0.033722367,
0.009563453,
-0.004070395,
-0.01011671,
0.00731749,
0.03208894,
-0.011802828,
0.021102825,
-0.004514977,
0.017625205,
-0.0182575,
0.002695484,
-0.009728112,
0.0069947564,
-0.010406512,
-0.014793054,
0.023131436,
-0.004152725,
-0.012013593,
-0.00804858,
-0.015478039,
-0.007745606,
0.013218904,
0.008661116,
0.0023612243,
0.008041994,
-0.013383565,
0.011289089,
0.0029902256,
-0.026569536,
-0.013936821,
0.0006977467,
-0.015925914,
-0.00567089,
0.016004952,
-0.002527531,
0.0038629235,
-0.00087516784,
-0.0051637376,
0.020325629,
-0.0037608342,
0.030798005,
-0.024909765,
0.012771029,
0.028716702,
0.02676713,
-0.009873013,
0.0065962793,
-0.027820952,
0.008568906,
0.026003106,
0.0090563,
0.018863449,
0.021287244,
0.004132966,
-0.0081671355,
-0.023473928,
0.021998575,
0.012533919,
-0.010360407,
-0.036119815,
-0.008298864,
-0.007936612,
0.0023678108,
0.02061543,
0.000299887,
0.012224358,
-0.020272939,
-0.022262031,
-0.020628603,
0.00031388312,
-0.005479885,
-0.014332006,
-0.017664725,
0.009695181,
0.024475062,
-0.0053613293,
0.014819399,
-0.00271195,
0.00066110987,
0.043022364,
-0.01962747,
0.018138945,
0.0027778142,
0.009141923,
0.009471243,
-0.005045182,
0.01924546,
0.016795319,
-0.009708353,
0.008977263,
0.015833706,
-0.020457357,
-0.0017371629,
-0.036594037,
0.021511182,
-0.047132276,
0.00074920297,
-0.022485968,
0.031641066,
0.021326762,
-0.0037838866,
0.01218484,
-0.003872803,
0.0024056826,
0.0024550804,
0.019811891,
-0.0017882076,
-0.0050682346,
-0.019140078,
-0.022657216,
-0.027425768,
0.013021313,
0.019956792,
-0.021906365,
-0.012560264,
0.033379875,
0.015570249,
-0.001290111,
-0.021208206,
-0.0380167,
-0.009853254,
-0.021181861,
0.009747871,
0.0118160015,
-0.004877229,
0.022947017,
0.0001284348,
-0.0070935525,
0.02089206,
0.017796451,
-0.0110849105,
0.014002685,
0.0036488655,
0.0049990774,
-0.01604447,
0.007172589,
0.01159865,
0.005015543,
-0.022788944,
0.030086674,
-0.019469397,
0.009405379,
0.0005857779,
-0.020602258,
-0.008555734,
-0.019548435,
-0.0022690147,
-0.015425348,
0.022999708,
0.015319966,
0.0015247515,
-0.02367152,
0.0019380482,
0.0138973035,
0.0060364353,
0.000029818895,
-0.014806227,
-0.008753325,
0.0128895845,
0.007818056,
-0.03938667,
-0.0022838342,
0.018046735,
-0.015794186,
0.014516425,
0.016452827,
0.009800563,
-0.0080815125,
0.027557496,
0.0034479802,
-0.004152725,
-0.030271092,
0.0199041,
0.010749005,
0.006250493,
-0.018402401,
-0.0026394997,
-0.012132148,
0.016795319,
0.006675316,
0.00008433679,
0.025963588,
0.019706508,
0.0057762726,
-0.0036291063,
-0.008707221,
0.030850695,
-0.019192768,
-0.008265932,
0.007515082,
0.00757436,
-0.005565508,
-0.016479172,
-0.016031297,
0.02433016,
0.013258423,
-0.0053152246,
0.009464656,
-0.0062010954,
-0.007824643,
-0.0076402235,
-0.011131016,
-0.00995205,
-0.017585687,
0.014608635,
0.024079878,
-0.0045709615,
0.01971968,
0.026740782,
0.011447162,
-0.008437178,
-0.030060329,
0.0045446157,
0.0029935187,
0.018191636,
0.013567983,
-0.021590218,
0.015886396,
0.0050879936,
0.027135966,
-0.011131016,
-0.044866554,
0.041994885,
-0.0059080007,
0.013324287,
-0.0148852635,
0.011098083,
0.0059541054,
0.011769896,
0.021959057,
-0.019284979,
-0.030877043,
0.0064777243,
-0.0057960316,
0.0013279829,
-0.022749424,
0.016255235,
0.0054601254,
0.038622648,
-0.04123086,
-0.009932291,
0.0095832115,
-0.0022245564,
-0.0074887364,
-0.018297018,
0.020114865,
-0.010380166,
0.019166423,
-0.006836683,
-0.01821798,
0.021326762,
0.025937242,
0.01858682,
0.02149801,
0.00797613,
0.021326762,
0.016057642,
0.004215296,
-0.030033983,
-0.0076402235,
-0.008351555,
0.004221882,
-0.004202123,
-0.016795319,
0.02065495,
-0.008417419,
0.007133071,
-0.027215004,
-0.017203676,
0.006609452,
0.002185038,
-0.017243195,
-0.01273151,
-0.02639829,
-0.003411755,
-0.02107648,
-0.007198935,
-0.008331795,
-0.014200278,
-0.0026641986,
0.0059837443,
-0.0068169236,
-0.0028881363,
-0.029085541,
0.026240217,
-0.024633136,
-0.009438311,
0.011809414,
-0.0130805895,
-0.003107134,
0.0076402235,
-0.023210473,
0.03693653,
0.027188659,
-0.012882998,
-0.016018124,
0.00526912,
-0.010676554,
0.025528885,
0.021432145,
0.0006269429,
-0.019219114,
-0.0042054164,
0.012039939,
-0.011453749,
-0.00091715617,
0.013528465,
0.0013106936,
-0.012784202,
-0.022248859,
0.021932712,
0.025686959,
-0.017809626,
-0.018744893,
-0.0179677,
-0.021115998,
-0.01298838,
-0.025423503,
-0.00036431022,
-0.030060329,
0.0062965984,
-0.015438521,
-0.0074689775,
-0.023157781,
0.019140078,
-0.0024962455,
0.02098427,
0.010814868,
0.04178412,
0.029348997,
-0.011651341,
-0.013712884,
0.012929102,
-0.020957924,
-0.012217771,
-0.005479885,
0.017730588,
-0.0124812275,
-0.008522801,
0.015122374,
0.022235686,
-0.030218402,
-0.009148509,
-0.020444185,
0.003559949,
0.028400555,
0.013567983,
-0.0046697576,
-0.031403955,
0.0042284685,
0.0015840292,
0.011427403,
0.022762597,
-0.028295172,
-0.018244328,
0.014648153,
0.001745396,
-0.023500275,
0.018428747,
-0.039702818,
-0.008417419,
0.01858682,
0.014081723,
0.011223225,
-0.013502119,
-0.008430592,
-0.02400084,
-0.0006372342,
0.0058421367,
-0.01966699,
-0.008246172,
-0.007844402,
0.029296307,
0.035645597,
0.022420105,
-0.0033557706,
0.010426271,
0.0031680583,
0.02654319,
0.038043045,
-0.018152118,
0.017941352,
-0.029559761,
-0.0071528303,
0.0034677396,
-0.007837815,
0.005384382,
-0.04615749,
0.034986954,
-0.0154648665,
-0.0057894452,
-0.03820112,
-0.0085096285,
-0.047079585,
-0.0038530438,
0.01920594,
0.0026526726,
0.01802039,
-0.03388044,
-0.010195747,
0.01232974,
-0.00600021,
0.011466922,
-0.002893076,
-0.0050056637,
-0.0067642326,
0.035065994,
-0.0018392521,
-0.0060166763,
0.0031351263,
-0.024237951,
0.0006178866,
-0.008825775,
0.032932,
0.0059606917,
-0.007475564,
0.014490079,
-0.0005359683,
0.013067417,
0.019811891,
-0.022288376,
-0.02328951,
-0.00025090066,
-0.004521563,
-0.02041784,
-0.02188002,
-0.023460755,
-0.030560894,
0.007831229,
-0.005354743,
-0.021366281,
0.015662458,
-0.03261585,
-0.03256316,
-0.0057367543,
-0.004370076,
0.0144769065,
0.0029013092,
0.025871377,
0.04128355,
0.006869615,
-0.018468264,
0.012962035,
0.008134204,
-0.011960902,
0.032589506,
0.0061549908,
0.016347444,
-0.010623863,
0.033379875,
-0.0015790893,
-0.013857785,
-0.023144608,
0.028268827,
0.0042581074,
-0.018455092,
-0.007541428,
-0.027188659,
0.002354638,
-0.005782859,
-0.025634268,
0.022499142,
-0.0062933047,
-0.016307926,
-0.0047059827,
0.023618829,
-0.022433277,
0.016228888,
-0.014595462,
-0.020957924,
-0.016716283,
-0.04183681,
-0.011223225,
-0.017190503,
0.004597307,
0.007936612,
0.009767631,
0.017098295,
0.0062867184,
-0.00971494,
0.007561187,
0.011078324,
-0.020325629,
0.04099375,
0.017941352,
-0.011532786,
0.003169705,
0.0038629235,
-0.015728323,
0.0038234051,
0.002185038,
-0.0018145532,
-0.027768262,
-0.019364014,
0.0383065,
0.020180728,
-0.00089328043,
0.018178463,
-0.023987668,
-0.0019989724,
-0.030956078,
-0.036515,
-0.009899359,
-0.024409197,
0.018428747,
-0.03340622,
0.0026329132,
0.008088099,
0.021774637,
0.026437808,
-0.0011073385,
0.030060329,
-0.02800537,
-0.0033788232,
0.007231867,
0.014819399,
-0.022933844,
-0.008483283,
-0.025344467,
-0.010887318,
0.027610188,
0.010472376,
-0.019508917,
-0.020220248,
0.01324525,
-0.0036686247,
0.00053061685,
-0.0021998575,
0.015609767,
0.008015648,
0.0069420654,
0.0067642326,
-0.017401269,
0.04225834,
-0.014358351,
-0.0089179855,
-0.0057598064,
0.008694048,
-0.011776483,
-0.0066621434,
0.0061978023,
-0.026582709,
-0.011921383,
-0.02122138,
-0.029849563,
0.016545037,
0.012007006,
0.011644755,
-0.012224358,
0.017849144,
-0.013376978,
0.0015403943,
0.014555943,
-0.019732853,
-0.027504805,
0.014753535,
-0.0024995387,
0.012790788,
0.0032273359,
-0.008391073,
-0.00029659382,
-0.015451694,
-0.0050649415,
-0.008496456,
-0.039307635,
0.03849092,
0.013436255,
0.009260478,
-0.01562294,
0.009734699,
-0.039729163,
0.0028634372,
-0.00014839982,
0.00955028,
0.009747871,
0.017440787,
-0.014463734,
0.026371945,
-0.012211185,
0.025107356,
-0.03222067,
-0.0022706613,
0.0025752822,
0.021195034,
0.017071947,
0.0029572935,
-0.013818267,
-0.02950707,
0.019298151,
0.010992701,
-0.0021669255,
-0.011447162,
-0.017058775,
0.02687251,
-0.018744893,
0.009010195,
0.010143056,
0.008904813,
0.017019257,
-0.010511894,
-0.022103958,
-0.0014457147,
-0.02630608,
-0.0038596303,
-0.036515,
-0.0036159335,
-0.00043511402,
0.015662458,
0.0051340987,
-0.024554098,
0.00056684203,
-0.01895566,
0.009201201,
-0.0005886595,
0.016110335,
-0.009135337,
-0.007231867,
0.0025950414,
-0.01723002,
0.0010892259,
0.00095008814,
0.015135546,
0.004524857,
0.0073240767,
-0.02606897,
-0.014279314,
0.017361749,
-0.03509234,
0.010650208,
0.0011649694,
-0.004063809,
-0.039676473,
0.006688489,
0.006158284,
-0.008766498,
-0.021353109,
0.009286824,
-0.0047817263,
0.0056083193,
-0.0034743259,
0.032826617,
0.0024419078,
-0.012033353,
-0.00035484228,
-0.021300416,
-0.0014885264,
0.0019199356,
-0.004808072,
-0.045841344,
-0.021959057,
0.19590588,
-0.022433277,
0.010406512,
0.013199145,
-0.002185038,
0.0023678108,
0.0074360454,
0.0036455723,
0.002832152,
-0.01225729,
0.016334271,
-0.003214163,
-0.0076797423,
0.0032273359,
-0.0026411463,
-0.009853254,
-0.03580367,
-0.007627051,
-0.0022459624,
-0.01651869,
-0.0013716178,
-0.0148852635,
0.01242195,
0.003428221,
0.03698922,
0.0231973,
-0.020865714,
0.013765575,
0.03424928,
0.005996917,
-0.03251047,
0.011131016,
0.00757436,
0.0428116,
-0.014332006,
0.004156018,
-0.011098083,
-0.01595226,
0.026082143,
0.020865714,
-0.00781147,
0.019179596,
-0.014898436,
-0.016782146,
0.000357518,
0.015109201,
-0.008325209,
-0.032747578,
0.0075546005,
-0.012224358,
-0.018982004,
-0.023645176,
0.000061284394,
0.0091748545,
0.011499854,
-0.0020977682,
0.022090785,
0.007903679,
0.005358036,
0.028927468,
-0.004811365,
0.018560475,
-0.035171375,
0.043417547,
-0.018033562,
0.023157781,
-0.023763731,
-0.002972113,
-0.0140685495,
-0.0138973035,
-0.00047504407,
-0.016887529,
-0.01723002,
-0.0064876038,
-0.0049957843,
0.0027926334,
0.02343441,
0.023645176,
0.01169086,
0.0038398711,
-0.020391494,
0.029190924,
-0.029770527,
-0.011881866,
0.000148194,
-0.033379875,
0.0335116,
-0.03190452,
-0.024027186,
0.0053975545,
0.010749005,
0.0070408615,
-0.0040769815,
-0.00575322,
0.0031548855,
0.008997022,
-0.0061418177,
0.010169401,
0.025278602,
-0.0353031,
-0.010801695,
0.077614136,
0.014463734,
0.021748291,
-0.014345178,
0.0016391902,
-0.003523724,
-0.02061543,
0.020826196,
-0.028769394,
-0.0069749975,
0.0048047784,
-0.0057598064,
-0.008549147,
-0.013113522,
0.024857072,
0.0075546005,
-0.016742628,
-0.013014725,
0.0024633135,
0.013963168,
-0.015240929,
-0.0032783805,
-0.0038299914,
-0.014332006,
-0.0031137206,
-0.003490792,
0.027504805,
0.0038168186,
-0.017822798,
0.0039254944,
-0.020299284,
-0.01891614,
0.02526543,
0.003095608,
-0.012580023,
0.022459622,
-0.013502119,
0.011974075,
0.02921727,
-0.007791711,
-0.012468055,
0.015319966,
-0.014147586,
-0.0068827877,
-0.03119319,
0.029085541,
-0.021853674,
-0.007383354,
-0.012968621,
-0.0125668505,
-0.01853413,
-0.02041784,
-0.021800984,
0.041441627,
-0.012836893,
-0.0027135967,
-0.034697153,
-0.009761045,
-0.0017174038,
-0.016294753,
0.038780723,
0.018455092,
-0.0065402947,
-0.008838949,
-0.01373923,
-0.1646073,
0.019456225,
0.013027899,
0.0030231574,
0.03135126,
0.000021573032,
-0.00910899,
0.010327475,
0.021563873,
0.034802537,
0.051347572,
-0.016228888,
-0.029849563,
0.020049,
0.017019257,
-0.021616563,
-0.038780723,
0.034512736,
0.025542058,
-0.012145321,
0.016676765,
-0.012132148,
0.008740152,
-0.013752403,
-0.02041784,
0.018705375,
0.01159865,
0.024725344,
-0.0069420654,
-0.025476195,
-0.0029984585,
-0.0027382956,
0.051505648,
-0.00863477,
0.039123215,
-0.033722367,
-0.012132148,
-0.018244328,
0.002893076,
0.004304212,
0.04671075,
0.015912741,
0.017612033,
-0.003523724,
-0.016386963,
0.015425348,
-0.0061549908,
0.00097561046,
0.030271092,
0.015899569,
0.028110754,
-0.004251521,
0.012244117,
0.021392627,
0.010050846,
-0.0011962549,
0.00030729672,
0.007580946,
-0.013923649,
-0.0034018755,
-0.010788523,
-0.023724211,
0.03298469,
-0.008022235,
-0.0000019730255,
-0.025792342,
-0.00097149395,
-0.009892772,
-0.0054107276,
0.010966356,
-0.02409305,
-0.007416286,
0.021787811,
0.00879943,
0.008015648,
0.0019380482,
-0.008997022,
-0.0016894116,
-0.008549147,
-0.011756724,
0.0019940324,
-0.017994044,
-0.0119016245,
-0.02041784,
-0.02023342,
0.014529598,
-0.0023365254,
0.011967489,
0.0031746447,
-0.0057137017,
-0.008351555,
-0.038043045,
-0.012435122,
-0.012691992,
-0.018652683,
0.024409197,
0.009332929,
0.00067016616,
0.02328951,
0.0030248042,
0.000946795,
-0.0060463147,
-0.0038168186,
0.020997442,
0.0058092047,
-0.007897093,
-0.033011034,
-0.006553468,
0.039360326,
0.02191954,
-0.0041922433,
0.0058586025,
0.013844612,
0.009484416,
-0.007383354,
0.008674288,
-0.03071897,
-0.004152725,
0.03148299,
-0.00848987,
0.051874485,
0.016228888,
-0.004063809,
0.017150985,
0.0007990126,
-0.030534549,
-0.12666965,
-0.039834544,
0.01604447,
-0.0074623907,
-0.016228888,
0.013469188,
0.0052822926,
0.005720288,
-0.009438311,
0.0148852635,
-0.029348997,
-0.009596384,
0.0055753873,
-0.029849563,
0.009886186,
0.0017190503,
0.0067576463,
-0.0046895165,
-0.043312166,
0.038280156,
-0.00072285737,
-0.015425348,
0.0012868178,
-0.012810548,
-0.00010610278,
-0.001100752,
-0.025594749,
0.02093158,
-0.0017042309,
0.015135546,
0.008226413,
0.0043536103,
0.001753629,
-0.001405373,
0.00812103,
0.021339934,
-0.007692915,
-0.018771239,
0.023500275,
-0.010966356,
-0.0055786804,
0.009319755,
0.0021092945,
0.011862106,
0.009332929,
-0.00682351,
-0.018231155,
0.0016655358,
0.001160853,
-0.026358772,
-0.00012051053,
-0.021260899,
-0.038569957,
-0.02950707,
0.011427403,
-0.018283846,
0.01849461,
0.02149801,
0.012053112,
0.006099006,
0.016821666,
0.0057927384,
-0.016492344,
0.01666359,
0.028874777,
-0.013554811,
-0.00788392,
-0.011585477,
0.022749424,
-0.048713014,
0.016834838,
-0.02691203,
-0.014358351,
-0.008588665,
-0.014081723,
0.004053929,
-0.008312036,
0.005904707,
0.0027432356,
-0.01844192,
-0.008819189,
-0.020496875,
0.031825483,
0.0006788108,
0.049898565,
0.00848987,
0.014200278,
-0.0012884644,
0.00304621,
-0.01183576,
-0.0038332846,
0.028400555,
0.011183707,
0.0067510596,
-0.020351974,
0.008885053,
0.004462286,
-0.011572304,
0.009043126,
0.008397659,
0.0015255748,
-0.0016737689,
-0.04794899,
0.007923439,
-0.010492135,
0.00094020856,
0.004498511,
-0.007139657,
0.0021932712,
-0.019956792,
-0.00071174285,
0.027583841,
-0.0179677,
0.015412175,
0.0065864,
0.0137260575,
-0.019087387,
-0.019495742,
-0.0031219535,
-0.004564375,
-0.007791711,
0.025660614,
0.0010768763,
0.0028387383,
0.004676344,
0.023697866,
-0.008219827,
-0.0026427929,
0.008628184,
0.029796872,
-0.0036192266,
-0.038675338,
0.02343441,
-0.015161892,
0.009115578,
0.00012287752,
-0.0027168898,
0.000033652384,
-0.0022937136,
0.034091204,
0.023249991,
0.057433404,
0.014977473,
-0.054640774,
-0.005502937,
-0.011895038,
-0.01595226,
-0.021195034,
-0.04215296,
0.015530731,
-0.0034809122,
0.0014210157,
0.021392627,
0.010235265,
-0.013818267,
-0.01694022,
0.0030429168,
0.008410833,
0.025634268,
-0.025660614,
-0.015899569,
-0.006059488,
0.01759886,
0.0011666161,
-0.008055167,
-0.0044392333,
-0.006592986,
-0.03248412,
-0.043918114,
0.015069682,
0.00271195,
0.011150775,
-0.008127618,
0.017098295,
0.010854387,
-0.003523724,
0.00394196,
0.009596384,
-0.010169401,
0.02301288,
-0.0022772476,
0.03395948,
0.005605026,
-0.0062472,
-0.045446157,
0.016176198,
0.034934264,
0.004715862,
0.011552545,
0.009049714,
0.003741075,
-0.0023035933,
-0.010867559,
0.02008852,
-0.010110124,
0.02687251,
0.020246593,
0.0076731555,
-0.007712674,
-0.0045116837,
0.005305345,
0.020220248,
-0.009537106,
0.00069239526,
0.0090036085,
-0.018389229,
-0.012784202,
0.0095832115,
-0.016123507,
-0.03656769,
-0.021853674,
0.0018063202,
-0.0064711375,
-0.011190293,
0.00089986686,
0.007251626,
-0.024409197,
0.010623863,
-0.0081868945,
0.031035116,
-0.010689727,
0.030376475,
-0.0032256893,
0.0011435637,
0.0099059455,
-0.0053810887,
-0.01670311,
0.03166741,
0.01712464,
-0.039571088,
0.013034485,
0.010880732,
0.017756933,
-0.011065152,
-0.029744182,
-0.02555523,
-0.011058565,
-0.035645597,
0.004554495,
0.021721946,
-0.009662248,
0.06623284,
0.024343334,
0.0010258318,
-0.021814156,
-0.026503673,
0.011822588,
0.012191426,
0.012382432,
0.015570249,
0.008476697,
0.016373789,
-0.00014099012,
0.0003221161,
-0.032299705,
-0.041599702,
0.020865714,
0.00861501,
-0.018626338,
-0.0017947939,
0.0028996626,
0.0065798135,
0.005980451,
0.022406932,
0.0007957194,
-0.018929312,
-0.008661116,
0.029190924,
-0.0030445633,
-0.0077060875,
-0.052822925,
-0.025607923,
-0.011802828,
-0.035540212,
-0.013311114,
0.010347234,
-0.023618829,
-0.017282713,
-0.004531443,
0.020365149,
0.009635903,
-0.006250493,
0.022499142,
-0.030376475,
-0.018863449,
-0.023118263,
-0.011354953,
-0.02041784,
-0.022314722,
-0.011071738
] |
BACKGROUND Whereas many causes and mechanisms of neurodegenerative diseases have been identified, very few therapeutic strategies have emerged in parallel. One possible explanation is that successful treatment strategy may require simultaneous targeting of more than one molecule of pathway. A new therapeutic approach to have emerged recently is the engagement of microRNAs (miRNAs), which affords the opportunity to target multiple cellular pathways simultaneously using a single sequence. METHODOLOGY/PRINCIPAL FINDINGS We identified miR-22 as a potentially neuroprotective miRNA based on its predicted regulation of several targets implicated in Huntington's disease (histone deacetylase 4 ( | [
-0.040036753,
-0.010325684,
0.019121638,
-0.026190048,
-0.02331521,
0.028669268,
-0.006428826,
0.011261985,
-0.014308259,
-0.001636878,
0.0102597475,
0.014532444,
0.0038803737,
0.017605092,
0.0081299925,
0.0075563435,
0.030700117,
-0.0067651034,
0.03325846,
0.011776291,
-0.036291547,
0.039667506,
0.000041261937,
-0.027535157,
0.0018363365,
0.02682304,
0.01840952,
-0.03465632,
-0.0021759104,
-0.0280099,
-0.001201696,
-0.008050868,
0.0083607705,
-0.010358652,
0.0038078432,
-0.01628636,
0.003850702,
-0.018739205,
0.014176386,
-0.0132532725,
0.00015083015,
-0.0028204415,
-0.003474863,
0.005802428,
-0.013259866,
-0.0012981284,
0.0045760055,
-0.012191692,
-0.006227719,
0.027640656,
0.013701642,
0.014176386,
-0.032546345,
0.0065442156,
-0.008479457,
-0.006811259,
0.00037048172,
0.030858366,
0.007246441,
-0.012382909,
-0.007464032,
0.008756391,
-0.033100214,
0.03201885,
-0.010398215,
0.011651011,
-0.003146828,
-0.0014044512,
0.008776172,
0.0066167456,
0.026255986,
0.014519257,
-0.003794656,
0.013240085,
0.016827041,
-0.023025088,
-0.02682304,
-0.016128112,
0.012653248,
-0.013457676,
0.024185574,
0.014136824,
0.0005814791,
0.005495822,
0.01544237,
-0.019490883,
-0.01484894,
0.018475458,
0.009692692,
-0.004968329,
0.01846227,
0.0111828605,
0.00014794542,
-0.0060068313,
-0.025319684,
0.02261628,
0.014150011,
0.021271173,
-0.013457676,
-0.0044243513,
-0.012297191,
0.0028616518,
-0.023222899,
-0.0010970215,
-0.02202285,
0.00033916178,
0.0020489823,
-0.014875315,
0.012910401,
-0.013991763,
-0.013688454,
0.009376196,
-0.013002713,
-0.014967626,
0.033390336,
0.012982932,
0.03455082,
0.020717304,
0.010114687,
-0.006076065,
0.024568006,
0.0135697685,
0.0042628064,
-0.026664793,
0.006870602,
-0.00054603815,
-0.029935252,
-0.005423292,
-0.009560819,
0.0021676684,
-0.006962913,
0.0055716494,
0.0050309687,
0.011479576,
-0.032256223,
0.008828921,
-0.005894739,
-0.018198524,
-0.016009426,
-0.039192762,
-0.002490758,
0.02479219,
-0.037636656,
-0.01504675,
0.0010417996,
0.020598618,
0.021297548,
0.015706116,
0.018778766,
0.01024656,
0.00059095747,
-0.021798667,
0.018449083,
-0.014374196,
-0.002170965,
0.0138862645,
-0.010879552,
0.024779003,
-0.0064090453,
0.0015767108,
0.02608455,
-0.020348059,
0.004750738,
0.018989764,
0.024159199,
0.007787122,
0.004368305,
0.008149774,
0.01752597,
-0.009824566,
-0.007965151,
0.031517733,
-0.029434133,
0.014440132,
-0.0048859078,
0.009910283,
0.020084312,
0.031860605,
-0.023974577,
-0.00893442,
-0.011031207,
-0.0027610983,
0.009145417,
-0.006471685,
-0.010938895,
0.021073362,
0.021917352,
-0.0056705545,
0.000046207188,
-0.028669268,
-0.012527969,
0.004599083,
0.0053705424,
-0.000841929,
-0.6266622,
-0.034366198,
0.00007953612,
-0.0129367765,
-0.0028171446,
0.018515019,
0.0027132942,
-0.0057793497,
-0.006415639,
0.040221374,
-0.023091026,
0.006231016,
0.0040485123,
-0.016958915,
-0.03162323,
-0.013325803,
-0.0072398474,
-0.038005903,
0.034287073,
-0.01116308,
-0.032440845,
0.018040275,
0.004289181,
-0.013015901,
-0.005637586,
0.017090788,
0.0010467448,
-0.004978219,
-0.010470744,
0.039667506,
-0.024660317,
0.016642418,
0.00037892986,
-0.006389264,
0.04755353,
-0.014901689,
-0.013470864,
0.04990088,
0.0034814565,
-0.00597716,
-0.011512544,
-0.0023621814,
0.027561532,
-0.006949726,
-0.019227136,
0.021020614,
0.011492763,
-0.020413997,
-0.004483694,
-0.0068376334,
0.0052551534,
0.022748154,
-0.018488646,
-0.011472982,
-0.007371721,
-0.0006704936,
0.014703879,
-0.032493595,
0.02153492,
0.008406927,
-0.018449083,
0.024779003,
-0.03270459,
-0.018053463,
-0.005327684,
0.00920476,
-0.0140313255,
-0.0059672697,
0.0098575335,
0.011618043,
0.0146643175,
0.031860605,
-0.01175651,
0.006326624,
0.042093977,
0.025702117,
0.00005269783,
0.017684218,
-0.015508307,
0.0071409424,
0.0027545048,
-0.011941132,
-0.038322397,
0.02297234,
0.034260698,
0.011064175,
-0.02162723,
0.012125756,
0.018158961,
-0.004599083,
-0.010457558,
-0.023025088,
-0.007345346,
-0.052696593,
-0.018554581,
0.020519495,
-0.0016945726,
0.021983288,
0.020598618,
-0.008479457,
-0.016958915,
0.020664556,
0.004826565,
-0.003916639,
0.01143342,
0.0063628894,
-0.025253749,
0.010727897,
0.025860365,
-0.014321446,
0.0053738393,
0.0032325457,
-0.030383622,
0.0080442745,
-0.021614043,
-0.0323881,
0.0007368424,
-0.006844227,
-0.013873077,
-0.020730492,
0.00597716,
-0.022339348,
-0.00762228,
-0.0027330753,
0.0007170614,
-0.0045694117,
-0.0003228837,
-0.02583399,
-0.010516901,
-0.0068574147,
0.008314615,
-0.019596381,
0.023539394,
-0.0035111282,
-0.009191573,
0.016299548,
0.0019434836,
0.0019500772,
-0.017750153,
-0.02761428,
-0.023130586,
-0.015152249,
0.021614043,
0.008453082,
-0.0066233394,
-0.02079643,
-0.01360933,
-0.016998475,
-0.0016039098,
0.0027017554,
-0.00048957986,
-0.007404689,
-0.018554581,
0.019213948,
0.033495832,
-0.005713413,
-0.017882027,
-0.021890977,
0.0040649963,
-0.036476173,
-0.00361333,
0.0282209,
-0.018053463,
0.007912401,
-0.039482884,
-0.03505194,
0.012574125,
0.034418948,
0.009910283,
-0.015284122,
0.0035111282,
-0.016602855,
-0.015323685,
0.008769578,
0.014479695,
0.009580599,
-0.0051925136,
-0.000112607486,
0.0004174616,
-0.012864246,
-0.01767103,
-0.024475696,
0.0013887913,
-0.00079494907,
0.021337109,
0.024739442,
0.023077838,
-0.009659723,
0.021178862,
0.032150723,
-0.00015999947,
0.022009663,
-0.012804903,
0.027798904,
0.010279528,
-0.021350296,
0.0057925372,
-0.006412342,
0.017301785,
0.019411758,
0.032493595,
-0.03732016,
0.005238669,
-0.029882504,
-0.009277291,
-0.023644892,
-0.00571671,
-0.019556819,
0.0023539395,
-0.012837871,
-0.009303666,
-0.012725779,
-0.02727141,
-0.032177098,
0.011881789,
0.027640656,
-0.0038441084,
-0.014189573,
-0.017235847,
-0.016945727,
0.011921352,
-0.0012931831,
-0.012481813,
-0.010628993,
0.013312615,
0.026348297,
0.004444132,
0.022339348,
0.010378433,
-0.00782009,
0.011466389,
0.004721066,
0.0033149666,
0.0044803973,
0.004724363,
0.01150595,
-0.0140313255,
-0.014941252,
0.049320634,
0.0020704118,
-0.007879433,
0.0022698701,
-0.007932182,
-0.0080442745,
0.0024413054,
-0.008288241,
0.031544108,
0.009244323,
-0.0033578253,
0.0219701,
-0.013820328,
0.011690573,
-0.02964513,
-0.016312735,
-0.0012676327,
-0.027798904,
-0.0016475928,
0.006811259,
0.058762766,
0.023091026,
0.028326398,
-0.0055749463,
0.0042001666,
-0.025702117,
0.0009412461,
0.014229136,
0.034023326,
0.011545513,
-0.015020375,
-0.022365721,
-0.0015775351,
-0.006949726,
0.012495001,
-0.037953153,
0.021904165,
-0.00008566617,
0.017552344,
0.01727541,
0.033627708,
0.015376434,
-0.019372197,
-0.020981051,
0.0361333,
0.000003815184,
-0.0123037845,
-0.010338871,
-0.02058543,
0.0027067007,
-0.011400452,
-0.0076948106,
0.015350059,
0.010127874,
-0.00072406715,
0.005680445,
-0.025820803,
-0.00071500085,
0.048001904,
-0.017934777,
0.021376671,
-0.019174386,
0.02227341,
0.0016475928,
-0.015363246,
-0.014769816,
0.028141774,
0.012191692,
-0.009686098,
0.015125874,
-0.008406927,
-0.014677505,
0.0019550226,
-0.0015585782,
0.02346027,
-0.0127059985,
-0.0035869554,
0.017354533,
-0.006989288,
0.017354533,
0.029829754,
0.028985765,
-0.00091899245,
-0.04726341,
0.0060496903,
0.005743085,
0.044968814,
0.022787716,
-0.0077739344,
-0.0034847534,
0.010510307,
0.027086787,
-0.0006012601,
-0.031385858,
0.030858366,
-0.01360933,
0.0035968458,
0.004430945,
-0.0112092355,
0.008433301,
0.018541394,
0.014163199,
-0.0036298141,
-0.025319684,
-0.014743442,
-0.006791478,
0.02534606,
0.0110378,
0.021600856,
0.0400895,
0.034128826,
-0.02361852,
0.003451785,
0.011677386,
0.010299309,
-0.017288597,
0.0034814565,
-0.006962913,
0.010206998,
0.032810092,
-0.014268697,
-0.02439657,
-0.005598024,
0.009580599,
0.018752392,
0.00025323805,
0.031253986,
-0.009092668,
0.012607093,
0.016088549,
0.007879433,
-0.0051529515,
0.0012157075,
0.005278231,
-0.026321921,
-0.006709057,
0.0002517957,
-0.0034979407,
0.0045793024,
-0.014835753,
0.0360278,
-0.0016253392,
-0.0044606165,
0.00846627,
-0.015521495,
-0.025530683,
-0.0010624047,
-0.026058175,
0.019293072,
-0.014822565,
0.007286003,
-0.014308259,
-0.023420708,
-0.009712473,
-0.014334634,
-0.006385967,
0.001371483,
-0.0060397997,
-0.037636656,
0.010292715,
0.0056474768,
0.029566007,
0.011545513,
-0.023486646,
0.014558819,
0.041988477,
-0.005298012,
-0.01668198,
0.008288241,
-0.025609806,
0.021455795,
-0.0021132706,
-0.013517019,
-0.0030891334,
-0.018356772,
0.016259985,
0.013543393,
-0.008064056,
0.04523256,
0.025596619,
-0.008387146,
-0.0029111044,
0.010905927,
0.024963627,
-0.0063398117,
-0.013009307,
-0.0058881454,
-0.032045227,
-0.01727541,
-0.047711782,
-0.009534444,
-0.039377384,
0.014374196,
0.012336752,
-0.0041573076,
-0.0121323485,
0.0004372426,
-0.002380314,
0.018620519,
0.026757104,
0.0055683525,
0.02356577,
0.00794537,
0.022880027,
-0.0013104915,
-0.002154481,
-0.0037386096,
-0.00054603815,
0.008677267,
0.004032028,
-0.011789478,
-0.0013385146,
0.01391264,
-0.010187217,
-0.042858843,
0.01163123,
-0.010305903,
0.058762766,
-0.010523494,
-0.032678217,
-0.020255748,
-0.011222423,
-0.0016426475,
0.007167317,
0.0030973754,
-0.014242323,
-0.005502416,
-0.007780528,
-0.009297072,
0.015930302,
0.024383385,
-0.042357724,
-0.007206879,
0.025860365,
0.010200405,
0.007918995,
-0.0042628064,
0.0067782905,
-0.028089026,
-0.01653692,
-0.034076076,
-0.022497594,
0.014229136,
-0.002281409,
0.023170149,
0.018673267,
0.031755105,
-0.01772378,
-0.029381383,
0.012686217,
0.026598856,
0.0006198048,
-0.0026044988,
0.016853414,
-0.022761341,
0.025016377,
0.019635944,
-0.0112685785,
0.014163199,
-0.025280124,
-0.008624517,
-0.0047804094,
0.009217948,
-0.022774529,
-0.00010276849,
-0.047659032,
-0.031122113,
0.013470864,
-0.026005426,
0.0014300017,
-0.032810092,
-0.0017028147,
0.029064888,
-0.010147654,
0.026176862,
-0.0054562604,
0.014585193,
-0.0085388,
0.0066002617,
-0.0039430135,
0.008037681,
-0.010002594,
0.01111033,
-0.0057925372,
-0.015574244,
0.019517258,
0.007009069,
0.012712591,
-0.009217948,
-0.008716829,
0.0074508446,
0.01831721,
-0.04663042,
-0.007444251,
-0.014308259,
-0.039430134,
-0.018093025,
-0.008261866,
-0.009765222,
-0.038929015,
0.016312735,
0.009448726,
-0.011275172,
0.007701404,
-0.03233535,
-0.005901333,
0.0027446141,
-0.015336871,
-0.0050309687,
-0.014928064,
0.034260698,
0.022537157,
-0.004585896,
-0.038005903,
0.0027297784,
0.00992347,
0.0012643358,
0.053171337,
0.019240323,
-0.013675267,
0.0032391394,
-0.0030545166,
-0.003324857,
0.0030297905,
-0.051562484,
0.030858366,
0.017947964,
0.0032028742,
0.0011019667,
-0.0071739107,
-0.021561295,
0.004750738,
-0.0035968458,
0.0019154606,
-0.005759569,
-0.020704117,
-0.018040275,
0.015481932,
0.009672911,
0.022800904,
-0.0044705067,
-0.008551987,
-0.016998475,
-0.0060859555,
0.0069365385,
-0.0076156864,
-0.014097262,
0.027113162,
-0.015336871,
0.00013413993,
-0.002830332,
-0.00826846,
0.011215829,
-0.016075362,
-0.008993763,
0.0422786,
-0.031122113,
-0.005555165,
0.020941488,
-0.011097143,
-0.0009354766,
0.010147654,
0.0025253748,
-0.017288597,
-0.026981289,
-0.0055716494,
0.032994714,
0.016022613,
0.0024775707,
0.0067585097,
0.00021367604,
-0.004130933,
-0.010292715,
-0.026124112,
0.026651606,
-0.018778766,
0.00076321705,
-0.009020138,
0.023473458,
0.01702485,
0.019464508,
-0.00702885,
-0.017908402,
0.020559056,
-0.009092668,
0.008723423,
0.0006375253,
-0.01935901,
-0.021442609,
-0.0075497497,
-0.026493357,
-0.032150723,
0.01772378,
-0.02088874,
-0.02261628,
0.023183336,
-0.025332872,
0.020928303,
0.023420708,
-0.014717067,
0.030620994,
-0.015534681,
-0.000727364,
-0.0015956677,
-0.011413639,
0.025306497,
-0.030779243,
0.002225363,
0.024739442,
0.023051463,
-0.01222466,
-0.003364419,
0.006969507,
-0.010055344,
-0.0021676684,
-0.00564418,
-0.027640656,
0.01360933,
-0.011822446,
0.007470626,
0.010167436,
-0.012204879,
-0.014123636,
0.0037880621,
0.007681623,
-0.011637824,
-0.027113162,
0.0017011663,
0.01366208,
-0.01722266,
-0.01234994,
-0.008209117,
0.0021132706,
-0.026519733,
-0.039113637,
-0.010635586,
-0.026124112,
0.035262935,
0.028405521,
0.003367716,
-0.0064255293,
0.0077673406,
-0.043729205,
-0.021587668,
0.01504675,
0.02058543,
0.018831516,
0.026651606,
0.000276728,
0.011275172,
-0.00439468,
0.0018940311,
0.021614043,
-0.01465113,
0.0018478754,
-0.0042759934,
0.023170149,
-0.0012264223,
-0.022141537,
-0.013741204,
0.027772529,
-0.0020819507,
-0.03336396,
0.012600499,
-0.0014176386,
0.011169674,
-0.015903927,
-0.0068640085,
-0.02153492,
0.0021083253,
0.013873077,
-0.009560819,
-0.005660664,
0.012448845,
-0.014097262,
-0.025754867,
0.007905807,
0.01274556,
0.01831721,
0.00918498,
-0.027904402,
-0.015204998,
0.009692692,
-0.023987764,
0.015600618,
0.015943488,
0.017301785,
0.016695168,
0.010879552,
-0.012567531,
-0.012481813,
0.00095031236,
0.0061057364,
-0.006751916,
0.011736729,
0.00023757809,
0.0058485833,
0.0037880621,
-0.009659723,
-0.024277885,
-0.0068574147,
-0.0072925966,
-0.0058090216,
-0.007635467,
0.008387146,
-0.011440014,
-0.0066002617,
-0.00918498,
-0.004167198,
-0.018079838,
-0.0066991667,
0.00558154,
-0.00013826098,
-0.029908877,
0.017169911,
0.008941013,
0.005182623,
-0.0023374553,
0.0018742501,
-0.009883909,
-0.008031088,
0.025728492,
0.19865403,
-0.0008983872,
0.013088431,
0.00087943044,
-0.0047968933,
0.0034254105,
0.026743917,
-0.000055891636,
-0.01116308,
0.00015999947,
0.010464151,
0.0049947035,
0.008802546,
0.004447429,
0.008400333,
-0.027245035,
-0.013299428,
-0.017961152,
-0.030541869,
-0.006811259,
0.0002917698,
-0.00774756,
0.009112449,
-0.0012552695,
0.020994239,
0.014374196,
-0.031438608,
0.006692573,
0.001190157,
0.005538681,
-0.034999188,
-0.006791478,
-0.010497119,
0.016892977,
0.010081719,
0.0014604974,
-0.01339174,
-0.00011219538,
-0.00933004,
-0.000138364,
0.0063497024,
0.024976814,
-0.018198524,
0.001857766,
0.016457794,
0.0073915017,
-0.0019484288,
-0.0096267555,
0.00059343013,
-0.0051364675,
-0.05380433,
0.006811259,
0.029618757,
0.02390864,
-0.004846346,
0.00069357146,
0.013101618,
0.02128436,
-0.007681623,
0.03178148,
0.0006902746,
-0.022748154,
-0.015336871,
0.038427897,
-0.026453795,
0.032810092,
-0.022734966,
0.0018363365,
0.028273648,
-0.006639824,
0.0071541294,
-0.029935252,
-0.014743442,
-0.008690454,
-0.0031484764,
0.00044424838,
0.052591097,
0.011730135,
0.0036693763,
0.00900695,
-0.0071541294,
-0.008519019,
-0.027561532,
0.006751916,
-0.0080179,
-0.04979538,
0.0049287667,
-0.005301309,
-0.008433301,
-0.0055881334,
0.014888502,
-0.00055057125,
-0.020282123,
-0.007793715,
0.011552107,
0.0035210187,
-0.003530909,
-0.004625458,
-0.014743442,
-0.024040513,
-0.042252224,
0.08898814,
-0.026255986,
0.014545632,
-0.013009307,
0.016418234,
-0.007582718,
0.006791478,
-0.0033578253,
-0.0057496782,
0.016866602,
-0.027060414,
0.015073125,
-0.022405284,
0.0028105509,
0.028484646,
0.019424945,
-0.023367958,
0.027693406,
-0.016273173,
-0.0066760886,
-0.013121399,
-0.0042562126,
0.026717542,
-0.01328624,
-0.0074574384,
-0.015139061,
-0.0057826466,
-0.0032094677,
-0.030752867,
-0.010154248,
-0.00026560118,
0.018290835,
0.01202685,
0.0039364197,
-0.00219734,
0.02608455,
-0.0081036175,
-0.0048957984,
0.0033710126,
-0.008149774,
-0.015165436,
0.0013418114,
0.024185574,
0.007088193,
-0.012930183,
-0.0040419186,
0.015851177,
0.005235372,
-0.015112687,
-0.023236087,
-0.009079481,
-0.0072398474,
-0.011130111,
0.0061848606,
-0.0027874731,
-0.023420708,
-0.027508782,
-0.012916995,
0.0078069028,
-0.016563294,
0.01702485,
0.010978457,
-0.0012717537,
-0.019227136,
0.0026242798,
-0.16499995,
0.027693406,
0.026493357,
-0.009435539,
0.034076076,
0.01078724,
0.01064218,
-0.004918876,
0.0035276124,
0.00031258108,
0.034629945,
-0.008453082,
-0.027693406,
-0.02514825,
0.0011407045,
0.02247122,
0.024858128,
0.044177573,
0.008921233,
0.008413521,
0.028458271,
-0.010305903,
-0.004711176,
-0.011690573,
-0.0043814923,
0.025847178,
0.0010566353,
-0.0055881334,
-0.0016228665,
-0.008842109,
-0.019227136,
-0.0047540343,
0.048186526,
-0.006712354,
0.031122113,
0.01831721,
-0.000058724854,
0.0055320873,
-0.026994476,
0.00038078433,
0.018937014,
0.036608044,
0.015481932,
-0.0071805045,
-0.023803141,
-0.0001312552,
-0.006969507,
-0.016312735,
0.0035111282,
-0.014928064,
0.010615805,
-0.01831721,
0.009297072,
0.00695632,
0.021416234,
0.016299548,
0.013767579,
-0.005228779,
-0.00518592,
-0.020348059,
-0.02975063,
0.011275172,
0.029064888,
0.011934539,
0.020176623,
-0.039034516,
-0.007879433,
0.0028072542,
-0.014809378,
0.01747322,
-0.056600045,
-0.02816815,
0.01668198,
-0.026203236,
0.015152249,
0.01623361,
0.0047540343,
0.016444609,
-0.002253386,
0.0058848485,
-0.020453557,
0.002225363,
-0.027113162,
-0.014717067,
0.027350534,
-0.021073362,
0.021917352,
0.0138862645,
0.0112949535,
0.001177794,
0.017301785,
-0.01846227,
0.020559056,
-0.009996001,
0.0381114,
0.009692692,
0.020282123,
0.012363127,
0.0004747441,
-0.0066134487,
0.01123561,
-0.009105856,
0.0077343723,
0.0046749106,
0.013345584,
-0.0011720245,
-0.008776172,
0.009409164,
0.039535634,
-0.013728017,
-0.0026523029,
-0.0012552695,
0.0058222087,
0.029249512,
-0.011215829,
0.00868386,
-0.0036265173,
-0.010536681,
-0.022800904,
-0.018765578,
0.06968188,
-0.005901333,
-0.0009123988,
0.011974101,
0.0067420253,
-0.045812804,
-0.13071287,
-0.034577195,
0.005640883,
-0.0014060996,
-0.036660794,
0.023091026,
0.0021033802,
0.032493595,
-0.009956438,
0.0282209,
-0.0320716,
-0.0033891452,
-0.0027973636,
-0.009745441,
-0.00233251,
-0.019016137,
0.009752035,
-0.008261866,
-0.016431421,
0.034207948,
-0.0077607473,
-0.0018050165,
0.010154248,
-0.010352058,
-0.00597716,
0.015996238,
-0.010582837,
0.007681623,
0.0064980597,
0.0057266005,
0.0046188645,
0.0016203938,
0.018699642,
0.0063562957,
-0.00933004,
-0.00861133,
0.015626993,
-0.025873553,
0.026176862,
0.007206879,
0.008242085,
0.0060035344,
0.0027099976,
0.013213711,
0.008703642,
-0.008176148,
-0.016470982,
0.0016657254,
-0.0047408473,
-0.0035506901,
-0.022049226,
-0.0048760176,
-0.023592144,
-0.015930302,
0.020005189,
-0.025266936,
-0.0127059985,
0.021192048,
-0.023776766,
-0.009501476,
-0.00695632,
-0.007345346,
-0.017011663,
0.005855177,
0.016774291,
-0.0323881,
-0.021257985,
-0.026757104,
0.009461913,
-0.014387383,
0.0004393031,
0.015415995,
-0.0019171089,
0.009501476,
-0.03515744,
0.025372434,
-0.002375369,
-0.023420708,
0.013873077,
-0.0032671625,
-0.023578957,
-0.031544108,
0.034471694,
-0.029275885,
0.036423422,
0.003242436,
0.014189573,
0.0057826466,
-0.013952201,
-0.008426707,
-0.0015272583,
0.03692454,
-0.013767579,
-0.0033545285,
0.0027924185,
0.009494882,
0.0052518565,
-0.020677742,
0.012363127,
0.036054175,
0.008275053,
-0.015917115,
-0.051747106,
0.013035681,
-0.010167436,
0.005278231,
0.0033413412,
-0.032889217,
0.005617805,
-0.0042232443,
-0.0036495952,
0.022115162,
-0.009910283,
-0.014928064,
0.010708117,
-0.0023407522,
-0.023288835,
-0.01732816,
0.031755105,
-0.008354177,
0.02167998,
0.033601332,
0.016655605,
0.00040262585,
0.014888502,
0.016180862,
0.00017895627,
-0.013556581,
0.00072200666,
0.011004832,
-0.0026654901,
-0.014862128,
0.016352296,
-0.02678348,
-0.0055287904,
0.008255272,
0.0029028624,
-0.02351302,
0.007886027,
0.031649604,
0.004918876,
0.029856129,
-0.017407283,
-0.046604045,
-0.0076750293,
0.004391383,
0.014519257,
0.011776291,
-0.023855891,
-0.0113542965,
-0.013477457,
-0.037583906,
0.028616518,
0.026717542,
-0.01182904,
-0.030620994,
-0.028880265,
0.014018138,
0.009593787,
-0.010661961,
-0.0044573196,
-0.014835753,
-0.0021248094,
0.012712591,
-0.017156724,
0.005344168,
0.00006140353,
0.006748619,
-0.025280124,
0.008373958,
0.020361247,
-0.014387383,
-0.028379146,
0.008558581,
0.018646892,
-0.013114805,
0.0032918886,
-0.016497357,
-0.034999188,
-0.0021989883,
-0.022458034,
0.01668198,
0.021046989,
0.010206998,
-0.025636181,
0.0132532725,
0.021429421,
0.011024613,
-0.005482635,
0.019728255,
0.0049980003,
-0.011446607,
-0.0045595216,
0.015310497,
0.000018943916,
0.021798667,
-0.0011983991,
0.024027325,
-0.01786884,
-0.024027325,
-0.008637705,
0.0070354436,
0.004510069,
0.01880514,
0.0017588609,
-0.024198761,
0.009989407,
0.028642893,
-0.035500307,
-0.001047569,
0.00564418,
0.0034320042,
0.0039529037,
0.02583399,
-0.022800904,
-0.0028665971,
-0.02040081,
0.014268697,
-0.0047738156,
-0.022101974,
-0.00021656077,
0.059554007,
0.014229136,
0.016787479,
0.015851177,
-0.009705879,
0.0016401749,
0.016352296,
0.02687579,
-0.021719541,
0.03829602,
-0.004661723,
0.015059938,
-0.009409164,
-0.03104299,
0.0028121993,
-0.0048925015,
-0.04459957,
-0.0031962804,
0.008097025,
-0.01653692,
0.0763283,
0.006072768,
-0.019517258,
-0.011927946,
-0.016405046,
0.023170149,
0.010589431,
0.009996001,
-0.025359247,
-0.015666556,
-0.0054265885,
-0.02450207,
0.011855415,
-0.039825752,
-0.017249035,
0.025055937,
-0.025332872,
0.04053787,
0.008255272,
-0.02673073,
0.026348297,
0.02297234,
0.012600499,
0.0073980954,
-0.017169911,
0.018726017,
0.034999188,
-0.014690692,
0.012125756,
-0.041065365,
0.0098575335,
0.0001846227,
-0.03766303,
0.0020324981,
0.018989764,
-0.0037056413,
0.0029242916,
-0.0064090453,
0.02687579,
0.00782009,
0.004641942,
0.019688692,
-0.002213824,
-0.01391264,
0.013780766,
-0.014374196,
-0.013873077,
-0.015125874,
-0.010279528
] |
To deliver optimal patient care, evidence-based care is advocated and research is needed to support health care staff of all disciplines in deciding which options to use in their daily practice. Due to the increasing complexity of cardiac care across the life span of patients combined with the increasing opportunities and challenges in multidisciplinary research, the Science Committee of the Council on Cardiovascular Nursing and Allied Professionals (CCNAP) recognised the need for a position statement to guide researchers, policymakers and funding bodies to contribute to the advancement of the body of knowledge that is needed to further improve cardiovascular care. In this paper, knowledge gaps in current research related to cardiovascular patient care are | [
-0.016670953,
0.0039407657,
0.0068420647,
-0.052762844,
0.0016817334,
0.015157805,
0.013361762,
0.024776168,
-0.031341918,
-0.0018470285,
-0.008671001,
0.009118367,
-0.006128253,
0.0029802453,
-0.012388084,
-0.017947262,
0.03452611,
0.0047697085,
-0.00999994,
-0.0057433867,
-0.045604993,
-0.00010639328,
0.0010863423,
0.012401242,
-0.010098624,
0.016644638,
0.019855145,
-0.019736724,
-0.0017022925,
-0.031710338,
0.012763082,
-0.0015600236,
-0.01723674,
-0.042210273,
-0.005013128,
-0.009572311,
-0.018302523,
-0.020815665,
0.016249903,
-0.014420967,
0.013907812,
-0.024618274,
-0.0005888123,
0.00011862594,
0.011467037,
-0.002759852,
0.009499944,
-0.007855216,
-0.022460392,
0.037078727,
0.007993373,
-0.0061447,
-0.01880252,
-0.0034802423,
0.020894613,
-0.02976298,
-0.021763029,
0.029368246,
-0.002759852,
-0.021710398,
-0.01018415,
0.0020591982,
-0.0074867974,
0.02186829,
-0.0068881167,
-0.020920929,
-0.0070723263,
0.031710338,
0.01247361,
0.019315675,
0.032710332,
0.021986712,
-0.012973607,
0.038447138,
0.020157775,
-0.012677556,
-0.0068552224,
-0.007078905,
-0.013460446,
0.019197254,
-0.0033815587,
-0.003578926,
-0.003144718,
0.013486762,
0.009124946,
-0.009124946,
-0.0064308825,
-0.0060295695,
0.011407827,
-0.0006011477,
0.02361828,
0.013045975,
-0.008743369,
0.0105459895,
-0.010230202,
0.017144635,
0.0031167578,
0.02235513,
0.024973536,
-0.019618304,
-0.0040789233,
0.0064407513,
-0.031657707,
-0.0069604847,
-0.00482234,
-0.024302486,
-0.032341912,
0.012664398,
0.035947155,
0.0071710097,
-0.01951304,
0.044210263,
-0.02422354,
0.0027466943,
0.02518406,
-0.024355117,
-0.009006525,
-0.003947345,
0.004772998,
-0.015355172,
0.0220525,
-0.004108528,
0.027105102,
0.010453885,
0.025473533,
0.0100328345,
-0.03294717,
-0.002536169,
-0.0037039253,
-0.0017187397,
-0.009973625,
-0.000572365,
0.004993391,
0.030447187,
-0.021197243,
-0.000018978608,
0.0076973224,
0.0043124743,
-0.024855115,
-0.03144718,
0.0047104983,
0.035631366,
-0.03218402,
-0.020420931,
-0.011289407,
0.03381559,
0.04826287,
0.019934092,
-0.0076841647,
0.006299305,
0.016828846,
-0.015368329,
0.003157876,
-0.013263078,
-0.027447205,
0.0074144294,
-0.019486725,
0.022460392,
-0.011967034,
-0.012947291,
-0.022131447,
-0.008105215,
-0.00087992894,
-0.003320704,
0.013670971,
0.008993368,
-0.0042203697,
-0.0110130925,
0.0054275994,
-0.006953906,
-0.008256529,
0.03218402,
-0.015355172,
0.0059802276,
-0.0022730127,
0.009447312,
0.009394681,
0.019907776,
-0.015092015,
-0.008842053,
0.007677586,
-0.010973618,
0.012052559,
0.018841993,
-0.018684098,
-0.006694039,
0.06189437,
0.005115101,
0.0077828486,
-0.022328814,
0.023710385,
0.024644589,
-0.0045164204,
-0.012967028,
-0.6366278,
-0.033736642,
0.013427552,
-0.015552538,
0.021841975,
0.015078858,
0.0068881167,
-0.009651259,
-0.009664416,
0.049341813,
-0.009973625,
0.0060361484,
0.005092075,
0.011243354,
-0.03452611,
-0.026013004,
0.007980215,
-0.015920958,
0.016118325,
-0.015499908,
-0.027184049,
0.00045271113,
0.00042105012,
0.008276266,
-0.005891412,
0.020052511,
0.01892094,
-0.00032216092,
-0.0015164383,
0.025618268,
-0.017723579,
0.034710318,
-0.023341967,
-0.0024374854,
0.037131358,
-0.0019177517,
-0.01373676,
0.012506505,
-0.0101709915,
0.008960473,
-0.01880252,
-0.0063848305,
-0.0102170445,
-0.011473616,
-0.009598627,
0.004434184,
0.024907745,
0.0019654487,
0.004802603,
0.012980185,
-0.00903942,
-0.015105173,
-0.014078863,
0.015394645,
-0.004424316,
0.004723656,
0.016105168,
-0.035578735,
-0.0056052296,
0.014657808,
-0.015828853,
0.005891412,
-0.030578764,
-0.03228928,
-0.01108546,
0.018460417,
-0.030684028,
-0.00012911107,
0.01680253,
-0.011473616,
-0.014434124,
0.007565744,
-0.0037927406,
-0.024394592,
0.032815594,
0.020526193,
-0.006055885,
0.004707209,
-0.027789308,
0.0051315483,
0.0011414406,
-0.020894613,
-0.027394574,
0.0015666025,
0.0292893,
0.032499805,
-0.005526283,
0.0006936636,
0.01934199,
-0.0077828486,
0.021920921,
0.02368407,
-0.0093288915,
-0.029684033,
-0.0038058984,
0.02934193,
0.02548669,
-0.010776252,
-0.00029584527,
-0.021315662,
-0.014552545,
0.012420978,
-0.013006502,
-0.0053058895,
0.0063058836,
0.027499836,
0.0016323916,
0.004223659,
0.041105017,
-0.04405237,
-0.012019665,
-0.017934104,
-0.0035822154,
-0.011967034,
0.00018626533,
-0.02186829,
-0.014513072,
0.020105144,
-0.0072696935,
-0.038157668,
0.020039354,
-0.0026661025,
0.013552551,
-0.007144694,
0.012611767,
0.0096117845,
-0.0007343706,
-0.0067828544,
-0.007815743,
-0.014592018,
0.015513065,
-0.038236614,
0.020815665,
0.0034572163,
0.012486768,
0.010440727,
0.010690725,
-0.01174993,
-0.012407821,
-0.011065723,
-0.007967058,
-0.014447282,
0.0123683475,
-0.0024029461,
0.0074144294,
-0.0053190473,
-0.008546001,
0.00427958,
-0.0049736546,
-0.012177559,
-0.031947177,
-0.026407737,
-0.023881437,
0.034789268,
0.006355225,
-0.005411152,
0.008789421,
-0.01596043,
-0.012920976,
-0.035894524,
0.006707197,
0.0056447033,
-0.01656569,
0.0044308947,
0.012486768,
-0.023591965,
-0.01024336,
-0.008046005,
-0.0044802367,
-0.027762992,
0.002868404,
-0.023184072,
-0.0068289065,
0.0142236,
-0.017092003,
0.008894684,
-0.015565697,
0.01186835,
-0.009052577,
-0.009565732,
0.0033634668,
-0.013894654,
-0.019249884,
0.0036973464,
0.01596043,
0.009072314,
0.03513137,
-0.009506523,
-0.014170968,
0.010434148,
-0.012934133,
0.025499849,
-0.024157751,
0.02097356,
-0.00020692722,
0.0091907345,
-0.013552551,
-0.007085484,
-0.000115747665,
0.026289318,
0.017526211,
-0.008874947,
0.021447241,
-0.015513065,
0.013881496,
0.00035258837,
0.015881484,
-0.007019695,
0.013894654,
0.00063938764,
-0.006272989,
-0.0036841885,
-0.012315716,
-0.01476307,
-0.024131436,
0.02163145,
0.009526259,
-0.0028914302,
-0.025210377,
0.013710445,
-0.0068881167,
-0.012559135,
0.030341925,
0.014828859,
-0.008697317,
0.019184096,
0.016644638,
0.02573669,
0.0044144476,
-0.0150657,
-0.0020690665,
0.0041249753,
0.013697287,
0.01728937,
0.017539369,
0.02501301,
0.0049243127,
-0.017789368,
0.034789268,
0.012980185,
0.00080797216,
-0.014723596,
0.0077696904,
0.008092057,
0.0049012867,
0.0060295695,
0.030920869,
0.036289256,
-0.015513065,
-0.01572359,
-0.0150657,
0.00034271998,
0.0023289334,
0.0041118176,
0.0067039076,
-0.0015863392,
0.013052554,
-0.0033305723,
0.040815547,
0.016315693,
0.021197243,
0.029973505,
0.010855199,
-0.008499949,
0.0004802603,
-0.017526211,
-0.009592048,
-0.014210441,
-0.012907818,
-0.012467031,
-0.009355207,
-0.02807878,
0.0054999674,
-0.01602622,
0.015026227,
0.01578938,
0.001352788,
-0.008519686,
0.009717047,
0.003476953,
-0.0075789024,
-0.01946041,
0.023776174,
0.017394634,
-0.012644662,
-0.0052466793,
0.0048058922,
0.02259197,
-0.02728931,
0.01476307,
-0.0037466881,
-0.0039012926,
0.008026268,
-0.022302499,
0.018394627,
-0.011467037,
0.017855156,
-0.006881538,
-0.004496684,
0.003121692,
-0.01174993,
-0.011920981,
-0.0035953734,
-0.04102607,
0.026973523,
0.0030082057,
-0.007394693,
-0.007644691,
0.008690738,
-0.008328898,
0.014315704,
-0.032210335,
0.0049440493,
-0.011335459,
0.029210351,
0.0015238395,
-0.024118278,
0.024420908,
0.022460392,
-0.016552532,
-0.0016134772,
-0.015565697,
0.001976962,
0.00915784,
0.0814732,
-0.010526253,
-0.009842047,
0.015289382,
-0.003151297,
-0.0022187368,
-0.0089078415,
0.005358521,
0.02361828,
0.007144694,
0.016842006,
-0.0027022865,
0.010611779,
-0.0062137786,
0.0065591712,
0.039552394,
-0.015999904,
-0.0032582043,
0.00542102,
0.0035690577,
0.016828846,
-0.011953876,
0.027341941,
0.046236567,
0.024920903,
-0.007006537,
0.012545978,
0.01373676,
-0.006062464,
-0.028973512,
-0.004203922,
0.026460368,
-0.017723579,
0.015092015,
-0.019973565,
0.018420942,
-0.008822315,
0.0013322289,
0.026223527,
0.005868386,
-0.0016044312,
0.0028930749,
0.0026644578,
-0.0005390593,
0.015407803,
-0.015368329,
0.00819732,
0.02271039,
0.009131525,
-0.015039384,
0.026341949,
0.0022763023,
-0.023841962,
-0.013309131,
0.021394609,
-0.015289382,
0.00056660845,
0.0029144564,
-0.00057195383,
-0.007815743,
-0.03157876,
-0.03331559,
0.0057400973,
-0.018881466,
-0.0012129862,
-0.0025805768,
-0.025381427,
-0.011361774,
0.009006525,
0.014552545,
-0.0028387988,
-0.00807232,
-0.004904576,
0.023999857,
0.024131436,
-0.0011381512,
0.021302504,
-0.0037762932,
0.010157834,
0.030762974,
-0.014210441,
0.010552568,
-0.022105131,
-0.012973607,
-0.0051118117,
0.002434196,
-0.007828901,
-0.030762974,
0.01632885,
0.013282816,
0.017789368,
-0.017710421,
0.015881484,
-0.0142236,
-0.011723614,
0.027210364,
0.026868261,
0.00080344913,
-0.0067269336,
-0.025986686,
-0.0032401122,
-0.005503257,
-0.0055164145,
-0.026526157,
0.016855163,
-0.00006501812,
-0.01982883,
0.0055591776,
0.023763016,
-0.020223564,
0.03289454,
-0.027394574,
0.013565709,
0.0066841706,
0.0076117967,
0.019605147,
0.0057039135,
0.026486684,
0.012763082,
-0.009045999,
-0.000757808,
0.01446044,
0.026565632,
-0.0038881346,
-0.016249903,
0.03523663,
-0.011381511,
-0.022341972,
-0.026789313,
-0.0053354944,
0.0057039135,
0.047131296,
-0.016605165,
-0.009717047,
-0.023355125,
0.0023190652,
0.010717042,
0.002837154,
-0.0056841765,
-0.020105144,
-0.006680881,
0.003960503,
0.019328833,
-0.005194048,
0.051131275,
-0.032736648,
0.01403939,
0.011045987,
-0.0047335243,
0.0067894333,
-0.0301314,
-0.0060920687,
-0.024302486,
0.0024358407,
-0.02644721,
-0.0077236383,
-0.01663148,
-0.020381458,
0.024920903,
0.041105017,
0.0059308857,
-0.019789355,
-0.022276184,
-0.00034189763,
0.007671007,
-0.015223593,
-0.0031562313,
0.011440721,
-0.015460434,
0.035473473,
0.033236645,
-0.0017467001,
-0.009105209,
-0.008118372,
0.02409196,
0.0010600266,
-0.000044047847,
-0.02742089,
-0.014499914,
-0.032999802,
-0.0137236025,
-0.018473575,
-0.016420955,
0.022605129,
-0.03126297,
0.0123683475,
0.037105042,
0.0074933763,
0.009197313,
-0.02060514,
0.014868332,
-0.009322313,
0.0037927406,
0.014631492,
0.027789308,
-0.036052417,
-0.03252612,
-0.04078923,
0.01807884,
-0.010723621,
0.007980215,
0.005105233,
0.01614464,
-0.018749889,
-0.01277624,
0.012572293,
-0.03789451,
-0.003254915,
0.009499944,
-0.02807878,
0.0245788,
-0.0091907345,
-0.027184049,
-0.016947268,
0.0019621593,
0.017039372,
-0.02168408,
0.024907745,
-0.0029572193,
0.000780423,
0.01988146,
-0.02849983,
-0.0005386481,
-0.017394634,
0.026026161,
0.008657843,
-0.0045032627,
-0.0072696935,
0.005430889,
0.0018157787,
0.0017993314,
0.023289334,
0.03242086,
-0.013934127,
0.0066446974,
-0.0038585297,
0.057052292,
-0.031605076,
-0.03192086,
0.035420842,
0.00061923976,
-0.0014893003,
-0.008085478,
-0.009638101,
-0.0088157365,
0.028868249,
0.0032318886,
-0.027447205,
0.01301966,
-0.0284472,
-0.017355159,
0.0007129892,
-0.028236674,
0.03368401,
-0.0026644578,
-0.009309155,
-0.019355148,
-0.0037105042,
-0.007434166,
0.00334373,
-0.018368311,
0.01572359,
0.013710445,
0.0045756306,
0.023841962,
0.010138097,
0.012822292,
0.012065718,
0.0011381512,
0.03910503,
0.007368377,
-0.006973643,
0.029131405,
-0.023052495,
0.006621671,
-0.017434107,
-0.015342014,
-0.037789248,
-0.02994719,
0.0011126578,
0.008098636,
0.0059308857,
-0.019920934,
-0.0075131133,
-0.0008922644,
-0.02169724,
-0.013697287,
0.0076512704,
0.02067093,
-0.017723579,
-0.026263,
0.015881484,
-0.0009769679,
-0.0011948942,
-0.0011611773,
0.010322307,
-0.014631492,
0.006121674,
0.0024786037,
0.022526182,
-0.012434136,
0.003144718,
-0.013342026,
0.012585451,
-0.032868225,
-0.025052482,
0.013092027,
0.00013795149,
-0.027315626,
-0.013855181,
0.008782842,
0.019736724,
-0.0021578819,
0.0048749708,
0.024052488,
0.0012409466,
-0.016407797,
0.011980192,
-0.023986699,
0.03126297,
-0.026973523,
-0.0072762724,
0.0393945,
-0.03205244,
0.002549327,
-0.020157775,
0.017578842,
0.015394645,
-0.021184085,
-0.00017012646,
-0.015828853,
0.012578872,
-0.033052433,
-0.027131418,
-0.0037433987,
-0.0013643011,
-0.017986735,
0.020499878,
0.026302475,
-0.008289425,
-0.012723608,
-0.00027117436,
0.006019701,
-0.0051841796,
-0.015170963,
0.009381523,
-0.025644584,
-0.023723543,
-0.01705253,
0.017381476,
-0.018947255,
0.025105113,
0.021841975,
-0.012447294,
-0.01518412,
-0.012394663,
-0.04947339,
-0.025052482,
-0.0005337139,
0.042631324,
-0.001298512,
0.0101709915,
0.026223527,
0.00074423896,
0.012427557,
0.0035690577,
-0.028789302,
-0.0045591835,
0.024565643,
-0.028631408,
0.03218402,
0.0088157365,
-0.023039337,
-0.0038091878,
0.040473443,
0.019565674,
-0.0038519506,
0.013223605,
-0.009276261,
-0.002646366,
-0.010578885,
0.014894648,
-0.019013045,
-0.015749905,
0.02090777,
-0.026539315,
0.0038486612,
0.0050953645,
-0.011315722,
-0.00982231,
-0.0042730006,
0.010855199,
0.012269664,
0.009782837,
-0.03278928,
-0.025815636,
0.0017318976,
0.003036166,
-0.015078858,
0.016381482,
-0.004115107,
0.032157704,
0.018355154,
0.01084204,
0.00025226,
-0.012052559,
-0.011684141,
-0.017486738,
0.010717042,
-0.01042099,
-0.008835474,
0.004309185,
-0.009789416,
-0.011124934,
-0.013670971,
-0.0027401152,
-0.001307558,
-0.025934055,
-0.0024325512,
-0.021644607,
-0.007565744,
0.010763094,
0.0023947225,
-0.030341925,
0.003766425,
-0.03018403,
0.0013141369,
-0.010045993,
0.011184144,
0.0005213785,
-0.004332211,
-0.012572293,
0.0010435793,
0.0049144444,
0.022184078,
0.012920976,
0.21305136,
-0.015934115,
-0.021499872,
0.01457886,
-0.015881484,
-0.0066973283,
0.002687484,
0.018144628,
-0.006934169,
0.012217033,
-0.00037253066,
-0.00012438248,
-0.01861831,
-0.004960497,
-0.0051743113,
-0.010263097,
-0.03494716,
-0.015236751,
0.0049736546,
0.0032269545,
-0.004555894,
0.009263103,
0.009486785,
0.0036480045,
0.028052464,
0.010927566,
-0.007921006,
-0.0034802423,
0.039841868,
-0.0019917644,
-0.017710421,
-0.005503257,
-0.012203875,
0.004259843,
-0.0020641324,
0.00074588374,
0.009763099,
-0.0013133145,
-0.0014202218,
-0.006200621,
-0.01910515,
-0.007361798,
-0.009111788,
-0.016407797,
0.011499931,
0.024789326,
-0.0051677325,
-0.014697281,
-0.007355219,
0.009690732,
-0.05621019,
-0.012967028,
0.022513025,
0.008078899,
-0.021934079,
0.012973607,
0.011263091,
0.010828882,
0.0014440704,
0.01826305,
-0.014394651,
-0.007960479,
-0.016644638,
0.029789297,
0.0109670395,
0.027341941,
-0.0074736397,
0.004506552,
-0.010763094,
0.0010674278,
0.012664398,
-0.026170896,
-0.0011217039,
0.011999928,
-0.014184126,
-0.025315639,
0.01644727,
0.013894654,
0.0028486673,
0.02765773,
0.00045476703,
-0.008664422,
-0.025749847,
-0.0027697203,
-0.014539387,
-0.05036812,
-0.007921006,
0.008059163,
0.0009564088,
-0.011098618,
-0.0006883183,
0.0144735975,
-0.03578926,
-0.009381523,
0.03205244,
0.027131418,
-0.004562473,
-0.0110130925,
0.009888099,
-0.003223665,
-0.0054900986,
0.08931526,
-0.007967058,
0.020684088,
-0.00049917464,
-0.0031003105,
-0.018907782,
0.011585457,
0.010467043,
-0.0011044343,
-0.0047993134,
-0.029052459,
0.010434148,
-0.016723584,
-0.008124951,
0.042683955,
0.023591965,
-0.016420955,
0.024815641,
-0.034684002,
-0.0101249395,
-0.0068946956,
-0.0033059013,
0.027315626,
-0.007296009,
-0.018144628,
0.021355135,
-0.0022302498,
-0.028210359,
-0.008342056,
0.012453873,
-0.014105179,
-0.0124144,
0.00072984764,
0.0022943942,
0.000415088,
0.006707197,
-0.024473539,
-0.0025394585,
0.015526223,
0.012723608,
-0.0076841647,
0.01036178,
0.027157733,
0.020407774,
-0.017026214,
0.014513072,
-0.0032878094,
0.0012960449,
0.0092828395,
-0.010295991,
0.0045262887,
0.001219565,
-0.014776228,
0.020855138,
-0.006115095,
0.005391415,
-0.031605076,
-0.013881496,
-0.008388108,
-0.0318156,
0.011111775,
0.022986704,
-0.020026196,
0.002180908,
0.0013092028,
-0.16557796,
0.027815623,
0.002187487,
-0.012670977,
0.03078929,
0.0071907467,
0.012539399,
0.002284526,
-0.0007364265,
0.00032339446,
0.007019695,
-0.014776228,
-0.005634835,
-0.017736737,
0.0132565,
0.0072631147,
-0.042894483,
0.04092081,
-0.0049736546,
0.014802543,
0.04228922,
-0.0072104833,
0.002223671,
-0.022249868,
-0.00040460285,
-0.019131465,
-0.040868178,
-0.006796012,
-0.0114473,
-0.006802591,
-0.004953918,
-0.0019013045,
0.053131264,
0.018776204,
-0.00034271998,
0.0058782543,
-0.01337492,
-0.037447143,
-0.02669721,
0.020434089,
0.028105095,
0.054210205,
0.011440721,
-0.032762963,
-0.022802496,
-0.015342014,
0.002662813,
-0.007427587,
0.0065723294,
-0.000115028095,
-0.0018651205,
-0.015315698,
0.007749954,
0.007309167,
0.01271045,
0.0034111638,
-0.011703878,
0.0001600525,
0.018368311,
0.004266422,
-0.0014810767,
-0.01969725,
-0.006039438,
0.007078905,
0.0010953882,
-0.026894577,
-0.0036249785,
0.0006611803,
-0.007940742,
0.010092045,
-0.01982883,
0.006499961,
-0.0060361484,
-0.022144604,
0.054683883,
0.0010197308,
-0.0018684099,
0.007302588,
0.0018749888,
-0.004812471,
0.012480189,
0.009993361,
-0.0105920425,
-0.029210351,
0.0078815315,
-0.016355166,
0.011559142,
-0.017078845,
0.03252612,
-0.010611779,
0.010881514,
-0.05181548,
-0.014078863,
-0.008684158,
0.012960449,
0.017802525,
-0.008828895,
-0.013236763,
0.0013379854,
-0.013486762,
0.025210377,
0.018026209,
-0.021986712,
0.026684051,
0.016434113,
0.008460476,
-0.0058716754,
0.0009802573,
0.04892076,
-0.00999994,
-0.0041743172,
0.02494722,
0.023026178,
0.012855186,
0.00542102,
0.030552449,
-0.017763052,
-0.027789308,
-0.018723572,
-0.026302475,
0.08052584,
0.0011167696,
-0.011776245,
0.020026196,
0.011611773,
-0.006736802,
-0.113473006,
-0.0029966927,
0.01928936,
0.008105215,
-0.0017467001,
0.021289347,
-0.024013015,
-0.010822304,
-0.010256518,
0.033052433,
-0.00807232,
-0.01801305,
-0.004138133,
-0.012249927,
0.025881425,
0.0033470194,
-0.026605105,
-0.042631324,
-0.03971029,
0.02728931,
0.0076183756,
-0.017999893,
0.011164407,
-0.0284472,
-0.0028470226,
-0.0045822095,
-0.002934193,
0.02301302,
0.017552527,
0.007368377,
-0.022210393,
-0.011368353,
-0.0031957047,
-0.013907812,
-0.008026268,
-0.019013045,
-0.0043124743,
-0.029894559,
0.03699978,
-0.019776197,
0.015342014,
0.022328814,
0.013309131,
-0.029736664,
-0.00951968,
-0.014618334,
-0.0059736487,
0.0032335334,
0.005983517,
-0.0042401063,
-0.018407784,
-0.006164437,
-0.035341896,
0.02163145,
0.015013068,
-0.008236793,
0.004960497,
-0.004749972,
-0.0043651056,
-0.024776168,
-0.022078816,
0.02060514,
-0.025407743,
0.01639464,
0.014605176,
-0.03452611,
-0.04102607,
-0.0058552283,
0.019026203,
-0.012519662,
-0.007980215,
-0.0042927377,
-0.010763094,
0.0050361543,
-0.044105,
-0.01223019,
-0.020894613,
-0.0097038895,
-0.00128042,
-0.0035493209,
-0.015868327,
-0.011789404,
0.04536815,
-0.011592036,
-0.0068223276,
0.013973601,
0.008657843,
-0.010282833,
0.01373676,
-0.01728937,
0.016052537,
0.025499849,
-0.017565684,
-0.015052542,
0.016552532,
0.008664422,
0.02849983,
-0.018539364,
-0.025776163,
0.01204598,
-0.010407832,
0.010986777,
-0.04297343,
0.0014111758,
-0.004246685,
-0.0020411063,
0.0089078415,
-0.020144617,
0.023644596,
0.0052565476,
0.02013146,
-0.013999917,
-0.04481552,
0.02511827,
0.014828859,
0.01693411,
-0.023039337,
0.0010953882,
0.042947114,
0.0067170653,
0.019197254,
0.021486714,
-0.028341936,
0.017144635,
0.00668746,
0.027315626,
0.009092051,
-0.00030160183,
0.017697264,
-0.00081742933,
0.005388126,
0.01826305,
0.017499896,
-0.016828846,
0.00662825,
0.021263031,
-0.0030394555,
-0.021473557,
-0.0036611625,
0.03018403,
0.0050526015,
0.04873655,
-0.015407803,
-0.023960384,
0.0016751544,
-0.037105042,
-0.0045164204,
0.0006114273,
-0.039815553,
0.038552403,
-0.014815701,
-0.017486738,
0.016920952,
0.005026286,
0.00093667203,
-0.029868243,
-0.007743375,
0.008256529,
0.028815618,
0.0115262475,
-0.00015881895,
-0.024447223,
0.022815654,
0.012815713,
0.012269664,
-0.008381529,
0.013039396,
-0.006322331,
-0.00837495,
0.011782824,
0.006397988,
-0.0022795917,
-0.02284197,
-0.0076183756,
-0.019144623,
0.0044670785,
0.0031003105,
-0.013348605,
0.009184156,
0.02403933,
-0.0020049224,
0.010236781,
0.010690725,
0.013486762,
-0.009032841,
0.01403939,
0.0057499656,
-0.015868327,
-0.017065687,
0.028473515,
-0.014947279,
0.0009827244,
0.0032647832,
0.018828835,
-0.0024325512,
0.015552538,
0.01831568,
0.030026136,
-0.006315752,
-0.00070846616,
-0.0012269664,
0.00909863,
-0.006187463,
-0.0061315424,
0.0013100251,
-0.011710457,
-0.023157757,
-0.011743351,
-0.021802502,
-0.011420985,
-0.009348628,
0.0012384795,
0.008506528,
0.012217033,
0.010855199,
0.003628268,
-0.00789469,
-0.006680881,
0.0031118235,
-0.002812483,
-0.01982883,
0.020026196,
-0.005368389,
-0.01307229,
0.012210454,
0.030236661,
-0.0033371511,
0.028605092,
0.027762992,
-0.0030920869,
0.018341996,
0.0142367575,
0.021736713,
0.0075460076,
-0.017578842,
0.008651264,
-0.0030328766,
-0.01373676,
0.0141446525,
0.014131495,
-0.029473508,
0.043762896,
0.013749918,
-0.015776223,
0.0068157488,
0.00012140141,
0.009657837,
0.012874924,
-0.006585487,
0.0017549237,
-0.02349986,
-0.0122894,
0.0028930749,
0.0031480074,
-0.01897357,
0.0059308857,
0.014249915,
-0.0022614996,
0.026341949,
0.0056973347,
-0.011611773,
0.017631473,
-0.002524656,
0.016710427,
0.010315728,
-0.027631415,
-0.02199987,
0.02934193,
-0.0056545716,
0.003993397,
0.0067499597,
-0.015170963,
0.007460482,
-0.024605116,
-0.013986759,
0.005651282,
0.0110591445,
0.0014942345,
-0.01193414,
-0.0031266261,
0.0029605087,
0.005990096,
0.019565674,
-0.03331559,
-0.0184341,
-0.024394592,
-0.011782824,
0.006187463,
-0.013907812,
-0.028473515
] |
Histone variants help specialize chromatin regions; however, their impact on transcriptional regulation is largely unknown. Here, we determined the genome-wide localization and dynamics of Htz1, the yeast histone H2A variant. Htz1 localizes to hundreds of repressed/basal Pol II promoters and prefers TATA-less promoters. Specific Htz1 deposition requires the SWR1 complex, which largely colocalizes with Htz1. Htz1 occupancy correlates with particular histone modifications, and Htz1 deposition is partially reliant on Gcn5 (a histone acetyltransferase) and Bdf1, an | [
-0.012789026,
-0.0128096305,
-0.005120418,
-0.022693308,
-0.011772498,
0.03321575,
-0.022349887,
0.0032109933,
-0.0067963162,
-0.012047235,
0.005745446,
-0.0043992326,
0.010962022,
0.0076857787,
-0.00741791,
-0.014684713,
0.010845259,
-0.021072358,
-0.011106259,
-0.011181812,
-0.020893779,
-0.0051410235,
-0.0012474795,
-0.013929185,
-0.01807772,
0.025660472,
0.015605084,
-0.022899361,
-0.010027915,
0.0015548419,
0.003080493,
0.008084148,
-0.016168296,
0.0058484725,
-0.006521579,
-0.030248586,
0.009780651,
-0.00859928,
0.012555499,
-0.010082862,
0.002683841,
0.02189657,
-0.0090457285,
0.0046087196,
-0.0021103267,
0.0013290421,
0.011305444,
-0.009588335,
0.0025464722,
0.020440461,
0.0049177995,
0.01785793,
-0.003932179,
0.023132889,
-0.033545434,
-0.027803425,
0.026924264,
0.01017902,
-0.007726989,
-0.008935833,
0.0009615809,
-0.008894623,
-0.029891428,
0.012088445,
-0.0027834333,
0.009581466,
0.00074050314,
-0.00057093863,
-0.007191251,
-0.01070789,
0.03739176,
0.0032281643,
-0.010556784,
-0.004567509,
0.018709617,
-0.038518183,
-0.013022552,
0.008159701,
0.010900206,
0.010858996,
0.016415559,
-0.004450746,
-0.016360613,
0.020028356,
0.019080512,
0.024946155,
0.0014526739,
0.005827867,
-0.023723574,
-0.0005627824,
0.015316609,
0.015467715,
0.027830899,
0.027130317,
-0.004296206,
-0.005831301,
0.010632337,
0.008846544,
-0.0041176267,
-0.04033145,
-0.01421766,
0.0028864597,
-0.010913943,
-0.018984353,
-0.029369427,
-0.009203702,
0.028050687,
-0.005954933,
-0.0068615666,
-0.009636414,
-0.025220893,
0.034067437,
-0.022198781,
-0.026883055,
0.039699554,
-0.01351708,
0.03291354,
-0.009876809,
0.00083537336,
-0.012582973,
0.028243003,
0.047035042,
0.013290421,
-0.02509726,
0.021924043,
0.0047976016,
-0.009196835,
0.0019489183,
-0.00070401456,
-0.016127085,
0.019643724,
0.000045100933,
-0.005638985,
0.00050912274,
-0.026374789,
-0.0055496953,
-0.0101927575,
-0.026567105,
-0.0090732025,
-0.03945229,
0.011429075,
0.033463016,
-0.026718212,
-0.01913546,
0.012919526,
0.022693308,
0.008867149,
0.018668406,
0.007933042,
0.009430361,
0.009251782,
-0.012658525,
0.010158415,
-0.0024297088,
-0.0050139576,
0.024121944,
-0.0048319437,
0.009148755,
-0.020825094,
-0.020550357,
-0.013208,
0.012102182,
0.017047456,
0.030138692,
0.024630208,
0.03241901,
-0.00082678784,
-0.016539192,
0.010261442,
-0.009849335,
0.00040566694,
-0.020412989,
-0.054755162,
0.022322413,
-0.009643283,
0.0025018274,
-0.00020068708,
0.013132447,
-0.028270477,
-0.0073560937,
-0.0013470717,
0.019863514,
0.018558512,
0.009272387,
-0.022940572,
0.003126855,
0.009931757,
-0.00090405776,
-0.009622677,
-0.009327334,
-0.0087366495,
-0.008860281,
0.006535316,
0.002685558,
-0.6206867,
-0.015550137,
-0.0033947239,
-0.02237736,
-0.0012380354,
0.02409447,
0.013359106,
0.021402042,
-0.010714758,
0.010694153,
-0.009615809,
0.0179953,
0.002417689,
-0.030358482,
-0.04849115,
-0.031759642,
-0.012260156,
-0.0069542904,
0.04681525,
0.009512782,
-0.042721663,
0.006109473,
-0.017981563,
0.011916734,
0.042721663,
-0.0033878554,
0.020042093,
-0.0045056934,
0.006713895,
0.031732168,
-0.038710497,
0.0370346,
-0.029232059,
0.009416624,
0.051623154,
0.012754683,
-0.0069130794,
0.01961625,
0.026182473,
0.028984794,
0.0087229125,
-0.012981342,
0.026402263,
0.00574888,
-0.003396441,
0.028517742,
-0.015852347,
0.023490047,
0.010735364,
-0.028737532,
-0.0079673845,
-0.015481452,
0.011820576,
0.011793102,
0.027666055,
0.011573313,
0.012699736,
-0.005580603,
-0.008812202,
0.0090594655,
-0.011738155,
0.011964814,
0.0005194254,
-0.0057076695,
-0.014904504,
0.005934328,
0.00710883,
0.017184824,
0.012582973,
0.0063120914,
-0.025839051,
0.0067345,
0.0018527603,
-0.012122788,
-0.008784728,
0.03725439,
0.0042687324,
-0.005305866,
-0.019712407,
0.02295431,
-0.0019180104,
-0.008626754,
-0.01259671,
-0.0128920525,
0.019204143,
-0.005577169,
-0.025330788,
0.038106076,
-0.011580181,
-0.0020313396,
-0.006270881,
0.018572249,
0.0041931793,
-0.0014612596,
-0.027240213,
0.034644384,
0.025248365,
0.0155364,
0.02329773,
0.0015084799,
-0.0031010984,
0.00049495656,
-0.0011813708,
-0.011566444,
-0.0020073,
-0.003945916,
-0.024561523,
-0.0012629335,
0.03181459,
-0.011841182,
-0.011209286,
-0.0063601704,
-0.036182914,
-0.0060442225,
0.0035166387,
-0.021841623,
0.026663264,
0.019245354,
-0.027652318,
-0.017967826,
0.037941232,
0.0044335746,
0.018503563,
-0.00956773,
0.009052597,
0.021566885,
0.02299552,
-0.004227522,
-0.0076376996,
-0.02185536,
0.013311027,
0.0053161685,
0.03593565,
-0.037364285,
-0.0077888053,
-0.005700801,
0.018242562,
0.005319603,
0.009876809,
-0.026910527,
-0.031265114,
0.003362099,
0.0055050505,
-0.0011564727,
-0.009080071,
-0.038957763,
-0.024012048,
0.005628682,
0.015234188,
0.008558069,
0.0090869395,
-0.010639206,
-0.036100492,
0.010948285,
-0.010110336,
-0.010735364,
-0.014945714,
-0.031155221,
-0.0038463236,
-0.015962243,
0.0065662237,
0.0065284474,
0.0132011315,
0.008894623,
-0.013283553,
-0.037858814,
0.002196182,
-0.00006160128,
-0.014286344,
-0.021127306,
0.0064735,
-0.0018184182,
-0.014231397,
0.0124456035,
0.005546261,
0.020783884,
-0.013469,
0.01052931,
-0.029506795,
-0.015618821,
-0.022294939,
0.0050654705,
-0.020701462,
-0.026388526,
0.036485124,
0.026278632,
0.0032504867,
-0.0033260395,
0.015440241,
0.03299596,
0.0083588855,
0.004000863,
-0.0030513022,
0.012582973,
-0.0020828529,
-0.015481452,
0.025660472,
0.0124593405,
-0.0057557486,
0.033133328,
0.020426726,
0.0031783683,
0.0006134371,
-0.022459783,
0.0068443953,
-0.031484906,
0.0028109069,
-0.0027456568,
0.003331191,
0.008578675,
0.0024348602,
-0.013894844,
0.0056115114,
0.020701462,
0.011484023,
0.014629766,
-0.021031147,
0.005381419,
-0.008832807,
0.0050482997,
0.017967826,
-0.0009272387,
0.014904504,
0.007960516,
-0.013681922,
-0.0043717586,
0.022212518,
0.012514289,
0.014258871,
0.009519651,
-0.012225814,
0.00058424624,
-0.001972958,
0.021182252,
-0.0008160559,
0.011456549,
0.031265114,
-0.010563653,
0.024204364,
0.009265519,
-0.0103576,
-0.015083083,
-0.0070470143,
-0.020921253,
0.02409447,
0.008200911,
0.024465365,
-0.0008649935,
-0.027089108,
0.018421141,
-0.009244913,
0.007823147,
0.008894623,
-0.0046087196,
0.01443745,
-0.0048079044,
-0.0032058419,
0.009121281,
0.018283773,
0.031539854,
-0.005165063,
-0.006507842,
-0.0052577867,
-0.02339389,
-0.011312312,
-0.0051513263,
0.0034015924,
-0.009135018,
-0.010508705,
-0.004766694,
-0.011813708,
0.016731508,
0.012885184,
-0.023091678,
0.0077475943,
0.013290421,
-0.0025464722,
0.022926835,
0.001383131,
0.0008310806,
0.0011890978,
-0.039946817,
0.025687946,
0.0065971315,
-0.0017025133,
-0.026924264,
-0.025426947,
-0.00017267674,
-0.010110336,
0.023201574,
0.003712389,
-0.0064700656,
-0.005796959,
-0.0021721425,
-0.008928965,
0.002749091,
0.0120815765,
-0.019053038,
0.0053505106,
-0.008496254,
0.004708312,
0.0042549954,
-0.025481893,
-0.010021047,
0.036842283,
0.010405678,
-0.013675054,
0.00089976494,
-0.011511497,
-0.014547345,
0.005371116,
0.0002425416,
0.016127085,
0.0008276464,
-0.008084148,
0.0035149215,
-0.009512782,
0.0083451485,
0.02509726,
0.0045091272,
-0.030578272,
-0.0098149935,
-0.008716044,
0.004275601,
0.020811357,
0.047776833,
-0.02975406,
0.0019094249,
0.0066211713,
0.012177735,
-0.022308676,
-0.022487255,
0.010288916,
-0.011525233,
-0.003908139,
-0.013743738,
-0.002622025,
-0.013846764,
0.010103468,
0.011284838,
0.008613017,
-0.03195196,
0.0059755384,
0.015302873,
-0.007349225,
-0.004086719,
0.009217439,
0.042639244,
0.02953427,
-0.006037354,
-0.0075621465,
0.034039963,
0.014190187,
-0.033270698,
0.0028675715,
0.013819291,
0.0043820613,
0.025207156,
-0.021360831,
-0.014066555,
-0.0036540073,
0.020632777,
-0.004121061,
-0.009141887,
-0.00023331215,
0.009773782,
0.03049585,
0.020673988,
-0.004488522,
0.0011564727,
0.033847645,
0.009986704,
-0.0321168,
-0.011422207,
-0.0015771644,
-0.016415559,
-0.010055388,
-0.025564315,
-0.0030461508,
-0.03395754,
0.012370051,
-0.02501484,
-0.0024039522,
-0.028064424,
-0.021910308,
-0.032061853,
-0.008832807,
0.003616231,
-0.009217439,
-0.003396441,
-0.00723933,
-0.029891428,
-0.017061193,
-0.00018029641,
0.0022167873,
-0.040001765,
-0.042062294,
-0.0017119574,
0.04607346,
0.030248586,
-0.004546904,
-0.0179953,
-0.003221296,
0.02211636,
-0.023792258,
-0.02307794,
-0.010810916,
-0.015673768,
-0.009670756,
-0.018160142,
0.020921253,
-0.015124293,
-0.013386579,
0.0075552785,
0.008180306,
-0.012699736,
0.026800632,
-0.016731508,
-0.001959221,
0.018929407,
0.029369427,
0.026141264,
0.008283332,
-0.010021047,
-0.007390436,
-0.019684935,
-0.000086231055,
-0.014506134,
0.01513803,
-0.0041313637,
0.008764123,
0.00076583045,
-0.011964814,
0.01105818,
-0.005168497,
-0.018984353,
-0.0037467312,
0.031759642,
0.026608316,
0.025852788,
-0.003066756,
0.013159921,
-0.03395754,
0.019286565,
0.013929185,
-0.015426504,
0.025385736,
-0.0105842585,
-0.015440241,
0.025852788,
0.0054329317,
-0.016099611,
0.008983913,
-0.00995923,
-0.0025499065,
0.034946598,
-0.00464993,
-0.010652943,
-0.019355249,
0.0044816537,
-0.00991802,
0.00097445917,
0.02031683,
-0.015701242,
-0.026251158,
-0.0024571826,
-0.023641152,
-0.022171307,
-0.029561743,
-0.032831118,
-0.0132423425,
0.024286786,
-0.0015651446,
0.000119339056,
0.012665394,
0.0012191472,
-0.01469845,
-0.021731727,
-0.0071156984,
-0.035386175,
0.02387468,
0.005453537,
0.020165725,
0.005656156,
0.030605746,
0.016003452,
-0.0060442225,
0.022885624,
0.019808566,
0.008372622,
-0.0067757107,
0.019932197,
-0.010261442,
0.021360831,
0.0053505106,
-0.00072633696,
0.026402263,
-0.00048980524,
0.027377581,
0.02329773,
-0.021278411,
-0.028064424,
0.014300081,
-0.035441123,
-0.02009704,
0.00082335365,
-0.011951077,
-0.011786235,
-0.03799618,
0.008125358,
0.0054226294,
-0.006617737,
0.020124514,
-0.00723933,
0.03167722,
-0.00612321,
0.021443253,
-0.008042937,
-0.0018871025,
0.015742453,
-0.012349445,
-0.0022236558,
0.008235253,
0.03695218,
0.006937119,
0.004251561,
-0.004024903,
-0.0034170463,
0.0045400355,
0.012239551,
-0.036265336,
-0.0009590052,
-0.032886066,
-0.0034462372,
-0.01627819,
-0.022899361,
-0.00040030095,
-0.039287448,
0.008283332,
-0.025674209,
-0.01215713,
0.010220231,
0.029287007,
-0.016580401,
0.04099082,
-0.005213142,
0.03645765,
0.0037295602,
0.0160584,
0.0147259245,
0.0018871025,
-0.01921788,
-0.009519651,
-0.023751048,
0.010639206,
0.031155221,
0.0094647035,
-0.018050246,
-0.0041657058,
0.019561302,
0.006394513,
-0.025632998,
-0.024341732,
-0.0160584,
-0.011964814,
0.014066555,
-0.009526519,
-0.0048216414,
-0.015165504,
-0.0054741427,
-0.0073698307,
0.043078825,
0.0021223463,
0.0023112283,
-0.0054604057,
-0.0025378866,
0.0028246439,
0.0027679792,
-0.0021566886,
0.0074316463,
0.007520936,
-0.015206715,
0.004330548,
0.0036471388,
-0.017404614,
0.039287448,
-0.029726585,
-0.004155403,
0.018654669,
0.036182914,
-0.017308455,
-0.0080292,
-0.004217219,
0.042199664,
-0.023105415,
0.002148103,
0.0008036069,
0.0185173,
0.0057385773,
0.01759693,
0.002718183,
-0.011751892,
-0.009622677,
-0.00060399296,
0.024753839,
0.011030707,
-0.0120815765,
-0.02619621,
-0.0075071994,
0.0014612596,
-0.029809007,
-0.039507236,
0.00053917215,
-0.050167046,
0.0050448654,
0.01601719,
0.018640932,
0.022816941,
0.01000731,
0.006476934,
-0.011113128,
0.031979434,
-0.025894,
0.011580181,
0.015852347,
-0.0027542424,
-0.041760083,
0.012644788,
-0.010701021,
-0.02743253,
0.0022665835,
-0.017926615,
-0.007836884,
0.0052234447,
-0.007404173,
0.020962464,
0.018132668,
0.0008499688,
-0.0028761572,
0.00013447108,
0.03093543,
-0.0040146,
-0.022322413,
0.0010251139,
-0.019561302,
0.0008538323,
0.0051856684,
-0.008853412,
-0.012617315,
0.0066143028,
-0.0045709433,
0.010254573,
-0.0027370714,
-0.0040798504,
-0.011484023,
-0.0090594655,
-0.0033912896,
0.002606571,
0.014203923,
-0.024685156,
-0.00868857,
0.009396018,
-0.011909866,
-0.017541982,
-0.033737753,
0.010309521,
0.0036643099,
0.023558732,
-0.015866084,
0.0074934624,
0.021319622,
-0.036924705,
-0.05107368,
0.0044644824,
0.0010388508,
0.039122604,
-0.0014432298,
-0.039946817,
-0.005213142,
0.0065765264,
-0.058683906,
0.004000863,
0.0072942777,
-0.0056904983,
0.0023163797,
0.018640932,
0.0014655523,
-0.028325425,
0.0062811836,
0.01983604,
-0.0023644587,
-0.024561523,
0.0011873806,
-0.020632777,
0.01509682,
0.0029757493,
-0.03335312,
0.003901271,
0.030138692,
-0.010089731,
-0.027157791,
0.039314922,
-0.0078094103,
0.035963126,
-0.010316389,
0.0045572063,
-0.011573313,
0.018338721,
0.021965254,
-0.022349887,
-0.0103576,
0.009238045,
0.00020723356,
-0.02773474,
0.008221516,
-0.014045949,
-0.010412547,
0.0077338577,
-0.0077750683,
-0.038710497,
0.0048937597,
-0.024341732,
0.01539903,
0.033930067,
0.01443745,
0.010185889,
0.020179462,
-0.008365754,
-0.01693756,
-0.013757475,
-0.020921253,
0.005467274,
-0.012205209,
-0.020509146,
-0.014313818,
0.014313818,
0.005340208,
-0.005261221,
0.023242783,
-0.0026426304,
-0.029039742,
-0.035303757,
0.018929407,
0.0035235072,
-0.016003452,
-0.009306729,
-0.016415559,
-0.010982627,
-0.0026185908,
0.009107545,
-0.020385515,
0.003870363,
-0.0044644824,
0.009155624,
-0.015028135,
-0.01952009,
-0.022088887,
-0.00096072233,
-0.018462352,
0.026031367,
0.18857975,
-0.008413833,
0.004742654,
0.015330346,
0.014547345,
-0.03387512,
0.026896792,
0.004024903,
0.008125358,
-0.003161197,
0.006779145,
-0.005429498,
-0.0030375654,
-0.001105818,
0.022212518,
-0.026072579,
-0.018421141,
-0.004931536,
-0.052584738,
0.019039301,
0.029122164,
-0.004735786,
0.008626754,
-0.011710681,
0.032199223,
-0.012843973,
-0.017500771,
-0.01847609,
-0.0035406782,
0.02553684,
-0.04577125,
-0.00074007385,
-0.0022305243,
-0.016662823,
-0.011985418,
-0.009856204,
-0.009224308,
-0.0006430572,
-0.000005768412,
0.011930471,
-0.007335488,
-0.0039974293,
-0.018682143,
-0.011044444,
0.0025997027,
0.010714758,
0.0018836682,
0.013475869,
-0.01601719,
-0.009650151,
-0.02457526,
0.0061541176,
0.015508926,
0.027885845,
0.009643283,
-0.011236759,
0.03678734,
-0.00017128159,
-0.028737532,
0.019327775,
-0.020069566,
0.00032024077,
-0.040743556,
0.0052062734,
-0.0035166387,
0.03269375,
-0.0038188498,
0.009430361,
0.014272608,
-0.01979483,
0.029644165,
0.002385064,
-0.017308455,
-0.009718835,
0.0016235263,
-0.019712407,
0.04475472,
0.027927056,
0.039067656,
0.023160363,
0.014368766,
-0.008757254,
-0.005453537,
0.006459763,
0.018379932,
-0.027240213,
0.04019408,
-0.0077888053,
-0.0064185522,
-0.0136338435,
0.0023180968,
-0.011051311,
-0.0050105234,
-0.004048942,
0.005226879,
-0.024066996,
-0.014918241,
0.020124514,
-0.00020830675,
-0.025811577,
-0.02681437,
0.07566268,
0.022926835,
0.0075552785,
0.0015531249,
0.00903886,
0.019053038,
0.0038051128,
0.011003233,
0.0045159957,
0.018613458,
-0.024437891,
0.0028246439,
-0.009993573,
-0.00037711998,
0.0025533407,
0.015234188,
-0.028600162,
0.058738854,
-0.024588997,
0.007960516,
-0.017033719,
0.028792478,
0.03519386,
-0.011415339,
-0.0036986521,
-0.019712407,
0.0069851982,
-0.037941232,
-0.03461691,
0.00899765,
0.008180306,
0.01707493,
-0.006731066,
0.012981342,
-0.030440902,
-0.0076102256,
0.0037055206,
-0.013798686,
0.031539854,
-0.0058656433,
-0.0070813564,
0.02285815,
0.012376919,
-0.021786675,
-0.016704034,
0.004090153,
0.0009830447,
-0.0030135259,
-0.020481672,
0.004062679,
-0.015605084,
-0.00287444,
0.009148755,
0.020440461,
-0.011738155,
-0.017954089,
-0.044425037,
-0.014506134,
0.022487255,
-0.03615544,
0.020426726,
0.032803643,
-0.03997429,
-0.005972104,
-0.0021120438,
-0.17462309,
0.025138471,
0.023586204,
-0.028105635,
0.023009257,
0.04296893,
0.016140822,
-0.014863293,
0.0015110556,
0.017280983,
0.0059308936,
0.0010963739,
-0.023902154,
-0.02409447,
-0.008839675,
-0.0078094103,
-0.013812423,
0.028297951,
0.022171307,
-0.0024348602,
0.016731508,
-0.013304158,
0.016800191,
-0.01737714,
0.018613458,
0.03079806,
0.0034582568,
0.0020279053,
-0.010330126,
-0.016786454,
-0.004897194,
0.0017325627,
0.024465365,
-0.0071294354,
0.0008860281,
0.0036265336,
-0.0007280541,
-0.009485308,
-0.0013496474,
0.016360613,
0.029863955,
0.0017325627,
0.003980258,
-0.022432309,
-0.006995501,
0.039122604,
-0.013283553,
-0.0020158857,
0.0075621465,
-0.015234188,
-0.007974253,
0.009588335,
0.016182031,
0.03425975,
0.015481452,
-0.00016752542,
0.010687284,
0.019822303,
-0.017294718,
-0.002670104,
-0.008166569,
-0.01149776,
0.03901271,
0.011195549,
-0.018338721,
-0.019327775,
-0.011250496,
-0.0037364285,
-0.01895688,
0.007919305,
-0.011944208,
0.011360391,
0.013894844,
-0.015124293,
0.011085654,
0.019245354,
-0.006020183,
0.0073217517,
0.015110557,
0.011346654,
-0.021580622,
0.010900206,
-0.031484906,
-0.026264895,
0.0009289558,
0.03401249,
-0.01421766,
-0.0035784545,
-0.005391721,
-0.0062331045,
0.007802542,
0.008729781,
-0.008365754,
-0.008764123,
0.026731947,
0.0029946375,
-0.0073698307,
-0.0013058612,
-0.02035804,
-0.003238467,
0.015481452,
-0.018503563,
-0.019533828,
0.015453978,
0.04678778,
0.014616029,
-0.016731508,
0.042227138,
0.05709043,
-0.0042790347,
-0.0017600365,
0.021539412,
0.0128645785,
0.013922317,
0.002022754,
0.041979875,
0.0011985418,
-0.00046061442,
0.0017737733,
-0.014107765,
0.068354666,
-0.002937973,
-0.026086316,
-0.003427349,
-0.01509682,
-0.034919124,
-0.1100598,
0.004182877,
-0.009396018,
-0.01254863,
-0.0058931173,
0.0040042973,
0.017802984,
0.023050467,
-0.022885624,
0.018613458,
-0.03511144,
0.00034406566,
-0.0012680847,
-0.02729516,
-0.015165504,
0.0034634082,
0.02225373,
-0.005226879,
0.011030707,
0.03475428,
0.017541982,
0.0031062497,
-0.017885404,
-0.025207156,
0.019987145,
-0.0063533024,
-0.040743556,
0.022542203,
0.012184603,
0.0029482755,
-0.014004739,
-0.009505914,
0.0027851504,
0.0048731547,
-0.017294718,
0.0075758835,
-0.026704475,
-0.018407404,
0.042089768,
-0.009711967,
-0.01623698,
0.010549916,
0.0045159957,
0.003808547,
-0.007850621,
-0.011195549,
-0.0028194925,
0.0057729194,
0.02707537,
-0.0029774664,
-0.021250937,
-0.0077682,
-0.02487747,
-0.030385956,
0.003695218,
-0.020454198,
0.022432309,
0.03579828,
-0.027569897,
0.027089108,
-0.0020862871,
0.009444098,
0.005542827,
0.0027508081,
0.016401822,
-0.0042069163,
0.0040523764,
-0.03019364,
0.012424999,
-0.039946817,
-0.016690297,
0.015714979,
-0.021209726,
0.016401822,
-0.022569677,
-0.0033294738,
-0.04898568,
-0.0008761547,
0.00251213,
-0.0375566,
-0.023009257,
-0.014492397,
0.01649798,
-0.040606186,
0.028023213,
0.0038291523,
0.01092768,
-0.0052234447,
0.0135926325,
-0.008613017,
-0.021511938,
0.05665085,
-0.0057763536,
-0.016552927,
-0.0014114634,
0.019863514,
-0.013695659,
0.0033088685,
0.014409976,
0.002968881,
-0.03645765,
-0.024685156,
-0.07379446,
0.008887755,
0.008901492,
-0.007582752,
0.007946779,
0.0014956017,
0.0040558106,
0.03511144,
-0.025962684,
0.003932179,
-0.014094029,
-0.01939646,
-0.03549607,
-0.01839367,
-0.02259715,
-0.014822083,
0.025825314,
-0.011779366,
0.020412989,
0.016731508,
0.0010311238,
0.0044679167,
0.004615588,
0.026100053,
0.0037570337,
-0.022652099,
-0.014066555,
-0.0010723344,
0.0051581943,
-0.002117195,
0.015948506,
-0.025042314,
-0.012438735,
0.0024983932,
-0.008441307,
0.008619886,
-0.010687284,
0.020151988,
0.020385515,
0.020509146,
-0.042556822,
-0.012315104,
-0.0139566595,
0.018668406,
-0.022514729,
0.01675898,
-0.035660915,
0.006950856,
0.0031938222,
-0.028847426,
0.042089768,
0.010749101,
0.03865555,
-0.035303757,
-0.025756631,
-0.001618375,
-0.0045228642,
0.0065181446,
0.010391942,
-0.002385064,
-0.0002841815,
0.031182693,
0.014423713,
0.013372842,
-0.0015660032,
0.011600787,
-0.0066898554,
-0.010089731,
0.0078987,
-0.026938,
-0.036347758,
-0.00682379,
0.03167722,
-0.007726989,
-0.0040180343,
0.019492619,
-0.011415339,
0.0037055206,
-0.011621391,
0.012658525,
0.018462352,
-0.010948285,
-0.024561523,
0.018366195,
0.036842283,
-0.006442592,
-0.018846985,
0.0026237422,
0.003174934,
-0.0013178809,
0.0021978992,
0.010364468,
0.01583861,
0.019025564,
-0.008819071,
0.024932418,
-0.0015342366,
0.011779366,
0.0117038125,
0.017129876,
0.00040523766,
0.013901712,
0.0035338097,
-0.0016750395,
-0.01535782,
0.038106076,
-0.034726806,
-0.018846985,
0.002544755,
-0.0077475943,
0.026429737,
-0.006476934,
0.0079261735,
0.0022957744,
-0.004612154,
0.010254573,
-0.011861787,
-0.026649527,
-0.012995078,
0.008963307,
0.007630831,
-0.0065971315,
0.0026117223,
-0.0043648905,
0.025399473,
-0.014094029,
0.028091898,
-0.016168296,
0.00034685596,
-0.010913943,
0.027199002,
0.0035990598,
-0.027501212,
-0.0060407883,
-0.0077475943,
0.012789026,
0.00007684062,
0.031155221,
-0.01667656,
0.09874062,
0.02553684,
-0.021374568,
0.012912657,
-0.011552707,
0.0037329944,
0.02277573,
0.010261442,
-0.006298355,
-0.01952009,
0.0030942298,
-0.04371072,
0.012528026,
-0.01755572,
-0.017349666,
0.011044444,
0.00087915966,
-0.0027508081,
0.00021324343,
-0.0062124995,
0.018654669,
-0.0071775145,
-0.005075773,
0.01057739,
-0.019904723,
-0.00074780086,
0.018091457,
0.018379932,
-0.02133336,
-0.015701242,
0.007472857,
-0.027501212,
-0.045001984,
-0.0079124365,
0.0001658083,
-0.012232683,
-0.0098012565,
-0.017349666,
0.010755969,
0.018833248,
0.010213363,
-0.024506574,
0.008097884,
-0.014849556,
0.025207156,
0.003602494,
0.018805774,
0.004378627,
-0.012006024
] |
Crude oils can be major contaminants of the marine ecosystem and microorganisms play a significant role in the degradation of its main constituents. To increase our understanding of the microbial hydrocarbon degradation process in the marine ecosystem, we collected crude oil from an active seep area located in the Santa Barbara Channel (SBC) and generated a total of about 52 Gb of raw metagenomic sequence data. The assembled data comprised ~500 Mb, representing ~1.1 million genes derived primarily from chemolithoautotrophic bacteria. Members of Oceanospirillales, a bacterial order belonging to the Deltaproteobacteria, recruited | [
-0.0021090256,
-0.026756654,
-0.009500054,
-0.02138885,
-0.047527723,
0.01665255,
-0.0132753635,
-0.0039469153,
-0.01887655,
-0.019274674,
-0.001264729,
0.023242183,
0.009678523,
-0.00527857,
-0.0022874947,
0.022267466,
0.03503488,
0.005697286,
0.0019665933,
-0.0037993349,
-0.025960406,
0.021141738,
0.0080105215,
-0.013865685,
0.0068298792,
0.021855615,
0.008690078,
-0.047362983,
-0.02704495,
-0.0085116085,
0.008099756,
-0.00802425,
-0.004825533,
0.012987067,
-0.010673832,
-0.0046470636,
0.026468357,
-0.012115314,
0.0060061757,
-0.012547758,
-0.0031077669,
0.010914079,
0.019123662,
-0.019796355,
0.010653239,
0.0010716734,
-0.0016259574,
-0.028198136,
-0.0066857315,
0.008175263,
0.01266445,
0.013295956,
0.0040327176,
-0.013172401,
-0.017078131,
0.015018871,
-0.025781937,
-0.021347664,
0.024628751,
0.007983065,
-0.013529339,
0.009026424,
-0.021937985,
-0.010454177,
-0.015362081,
0.0057419036,
0.014359907,
0.016034773,
0.0043587675,
-0.002429927,
0.02609769,
0.018313687,
-0.0044274093,
0.016597636,
0.018313687,
-0.006881361,
-0.021663416,
-0.018272502,
0.011868203,
0.015005142,
0.022377294,
-0.017311513,
-0.013007659,
0.005203064,
0.0056561013,
-0.027017493,
0.018752996,
0.00057659287,
0.006720052,
-0.022006627,
0.01184761,
0.03681957,
0.027058678,
-0.0058277063,
-0.015636649,
0.001439766,
-0.024779763,
0.041514684,
0.003148952,
-0.031657692,
-0.023036256,
-0.0012286919,
-0.009733437,
-0.020194478,
-0.02471112,
0.01219082,
0.026029048,
-0.012437931,
0.002608396,
-0.000036278372,
-0.0064557805,
0.023859961,
0.0053918296,
-0.023406923,
0.019439416,
0.003531631,
0.017105587,
-0.004612743,
0.00246768,
-0.021004453,
0.010989585,
0.0035487916,
0.02197917,
-0.02498569,
0.0060336324,
0.006311632,
-0.011133733,
-0.008580251,
0.008140942,
0.000030835276,
-0.01034435,
0.00403615,
0.008985238,
0.0077840034,
-0.01107882,
0.024573838,
-0.038247325,
-0.002019791,
-0.011490672,
-0.034375917,
-0.0049147676,
0.02276169,
-0.010564005,
0.0016568464,
0.008648893,
0.008683214,
0.028102037,
0.019906182,
-0.006363114,
-0.0067612375,
0.0037547178,
0.019041292,
0.004684817,
0.0051996317,
0.013831364,
0.0005860311,
-0.006469509,
0.01416771,
-0.03418372,
-0.01103077,
-0.0010356363,
-0.020880898,
0.015005142,
-0.0160485,
0.022528306,
0.01786065,
0.029845543,
0.0068744966,
0.003044273,
0.0013265067,
-0.0051515824,
0.014922772,
-0.01103077,
0.023750134,
0.0037993349,
0.013872549,
0.003420088,
0.0143873645,
0.0060130395,
-0.04568812,
0.0022977912,
0.01055714,
0.006472941,
0.007948744,
0.006229262,
-0.019549243,
0.023750134,
0.005402126,
0.03426609,
-0.021237837,
-0.008834226,
-0.00534378,
-0.0019219761,
0.013357734,
-0.6462233,
-0.026852753,
-0.005402126,
-0.013934327,
0.012149635,
0.0035179027,
0.027237147,
0.0033119768,
-0.02464248,
0.021539861,
0.015362081,
0.025424998,
-0.023022529,
-0.01657018,
0.021539861,
-0.021869343,
-0.004084199,
-0.028170679,
0.025342628,
-0.021443762,
-0.03821987,
-0.022679318,
-0.012142771,
0.009946226,
-0.0034338164,
0.008017386,
0.020469045,
-0.02224001,
-0.005096669,
-0.0069671636,
-0.008820497,
0.013323413,
-0.016295612,
0.0027473962,
0.053348567,
-0.013385191,
0.0033445817,
0.024848405,
0.025122974,
0.012156499,
-0.005302595,
-0.020167021,
0.023475565,
-0.012012351,
-0.0073103737,
0.04294244,
0.02902184,
0.0053986935,
-0.016213242,
0.0063528176,
0.02052396,
0.0061365953,
-0.006273879,
-0.0007391886,
0.013357734,
-0.030092655,
0.0028966926,
-0.026976308,
0.01279487,
0.03418372,
0.014758031,
0.028555075,
-0.012554622,
-0.028198136,
-0.03632535,
-0.0020146428,
-0.04642945,
-0.013515611,
0.0018447539,
-0.007667312,
0.016089685,
0.020496503,
0.009074473,
-0.019329589,
0.011360251,
0.031657692,
0.024367912,
-0.022528306,
-0.010056053,
0.012458524,
0.02918658,
0.010179609,
-0.02678411,
0.007735954,
0.02137512,
0.0016860192,
-0.019082477,
-0.0039881007,
-0.0035350632,
-0.015870031,
0.014263809,
0.054748863,
-0.0069946204,
-0.017174229,
-0.005511953,
0.0076947687,
-0.0041974587,
-0.0030425568,
0.016364254,
-0.03492505,
-0.010598325,
-0.016625093,
0.022940159,
0.0050520515,
0.032755964,
-0.032975618,
-0.015471908,
-0.0025757912,
0.009300992,
-0.01313808,
0.02850016,
0.020633787,
-0.01361171,
-0.008305683,
-0.019137392,
-0.020729886,
0.0024488035,
0.025534825,
-0.008182127,
-0.032701053,
0.0032604951,
0.018725539,
-0.010371807,
-0.021004453,
0.006462645,
0.02248712,
0.0008923461,
-0.024450282,
-0.009980547,
-0.013673487,
0.003425236,
0.0008940621,
0.015211068,
-0.021622231,
0.012719364,
0.040141843,
0.025685837,
0.011868203,
-0.028747272,
-0.02240475,
-0.027539173,
-0.012705635,
0.002805742,
0.007028941,
-0.013515611,
-0.020867169,
-0.021677146,
-0.003802767,
-0.0047157058,
0.0018962354,
0.020839714,
0.0138107715,
-0.010666967,
0.01274682,
0.00697746,
0.007399608,
-0.0038542487,
-0.025438728,
0.008175263,
-0.0044239773,
0.0033806188,
0.011168054,
-0.017133044,
-0.0018584823,
-0.008003658,
0.000049229187,
0.015513093,
0.025315171,
0.022308651,
-0.015801389,
-0.0062429905,
-0.03245394,
-0.0055908915,
0.0048426935,
-0.0038885695,
0.004616175,
-0.042365845,
-0.01013156,
0.008950917,
-0.010179609,
0.009136251,
-0.007955608,
-0.0027130751,
0.0018756428,
0.025809394,
0.007667312,
0.037368707,
-0.010145288,
-0.004111656,
0.046484366,
0.011133733,
0.022624405,
0.027745098,
0.005786521,
0.0000573268,
-0.032426484,
0.005446743,
-0.007639855,
0.019727712,
0.011168054,
0.011387709,
-0.011202375,
-0.006891657,
-0.034321003,
0.0052133603,
-0.021059368,
-0.002635853,
-0.016172057,
0.03786293,
0.0058688913,
0.005889484,
-0.018807909,
-0.018533342,
0.0076467195,
-0.0054227184,
0.0066136573,
-0.0023029393,
0.01292529,
0.0034732854,
-0.009939362,
0.005058916,
-0.027003765,
0.016885933,
-0.014112797,
-0.010186474,
0.01562292,
0.019109935,
-0.0025775072,
-0.03182243,
0.010859165,
0.011778968,
0.0043587675,
0.008140942,
-0.00007126971,
0.025905492,
0.030724162,
-0.007248596,
0.009980547,
0.017187959,
-0.0017040378,
-0.018217588,
0.025191616,
0.012142771,
-0.010021733,
0.036105696,
-0.002767989,
0.0135430675,
-0.008422374,
-0.013385191,
-0.013337142,
-0.0018962354,
-0.014263809,
-0.019466873,
-0.020029737,
-0.0015006858,
-0.009554967,
0.011792696,
-0.00033076867,
0.037121598,
-0.001230408,
0.00056029035,
0.0065656076,
-0.008195856,
-0.023544207,
0.011257289,
-0.006061089,
0.01733897,
-0.004139113,
-0.036270436,
-0.0057796566,
-0.0084704235,
0.0075506205,
0.0017563773,
-0.015979858,
0.004310718,
-0.004973113,
0.017819464,
0.0005302595,
0.009108794,
-0.007564349,
-0.013728401,
-0.018615711,
0.025232801,
0.03220683,
0.0037203967,
-0.02696258,
-0.04387597,
0.0011205807,
-0.0015487352,
-0.007262324,
0.0077977316,
0.014524648,
0.008957782,
0.0033360014,
-0.011511264,
-0.0011892227,
0.0015281426,
-0.031712607,
0.005402126,
0.005144718,
0.00897151,
0.006297904,
-0.008188991,
-0.0080723,
0.03907103,
-0.006768102,
-0.028939469,
0.009019559,
-0.002596384,
-0.024464011,
0.0063459533,
0.0036792115,
-0.012842919,
0.00697746,
-0.030284852,
0.023132356,
-0.010824844,
-0.012870376,
0.010062918,
0.013886278,
-0.0014311858,
-0.036188066,
-0.0052957307,
0.004736298,
0.033854235,
0.012293783,
0.0075986697,
0.031136014,
0.020112107,
0.008607707,
-0.020839714,
-0.00513099,
0.0006255003,
-0.0043621995,
0.0007722225,
0.007543756,
0.016721193,
0.017640995,
0.013440104,
-0.01197803,
0.0018344576,
-0.027017493,
-0.009300992,
-0.012650722,
-0.0029275815,
-0.028747272,
-0.0019665933,
0.038988657,
0.03596841,
0.010872894,
0.009506918,
0.023571664,
0.009850128,
-0.00854593,
-0.004176866,
0.003802767,
-0.007406472,
-0.0006950003,
0.013302821,
0.01163482,
0.044013254,
0.027374431,
0.01348129,
0.020729886,
0.006644546,
-0.001677439,
0.004684817,
-0.022006627,
-0.0030717298,
0.0073103737,
-0.00003708277,
0.046182342,
0.0028160382,
-0.02137512,
0.013440104,
0.0071319044,
-0.0147717595,
-0.016089685,
0.00836746,
-0.025370086,
0.025287714,
0.011449486,
0.004894175,
-0.0027336678,
-0.0074407933,
-0.03638026,
0.017764552,
-0.014304994,
-0.02051023,
-0.00067011756,
-0.019096205,
-0.00048735822,
-0.035144705,
0.0047568907,
-0.005093237,
-0.038082585,
-0.028802184,
-0.008065435,
-0.007200546,
0.0051515824,
0.006054225,
-0.019370774,
0.008271362,
0.0025397541,
-0.017558625,
-0.0016130871,
0.0218007,
-0.037039224,
0.01769591,
-0.0044754585,
-0.0004989416,
-0.0061434596,
-0.016034773,
0.015403266,
0.001541013,
0.010399263,
-0.005659533,
0.023297096,
-0.0021347664,
0.0016319636,
0.03476031,
0.013474425,
-0.0035762484,
-0.019206032,
-0.011538721,
-0.032591224,
-0.00042600944,
-0.010062918,
-0.010186474,
-0.025466183,
-0.042036362,
0.0045029153,
-0.002018075,
0.0024711122,
0.018849095,
-0.02256949,
-0.0016259574,
0.0022806306,
-0.011998623,
0.015018871,
0.0105845975,
0.008978374,
-0.013748993,
0.02042786,
0.004832397,
0.004554397,
0.021430034,
0.01425008,
0.015595463,
0.0005898922,
-0.015815118,
-0.010564005,
-0.04286007,
0.01292529,
-0.009932498,
0.014483463,
-0.015018871,
-0.032701053,
-0.019727712,
-0.01974144,
0.0034818656,
0.006325361,
-0.018231317,
-0.026248703,
-0.023544207,
-0.0057522,
-0.008573387,
-0.022308651,
0.026633099,
-0.027703913,
-0.02626243,
0.017448798,
-0.000068534755,
0.00032690755,
-0.02488959,
-0.0059478297,
-0.0051172613,
-0.0117377825,
-0.031383123,
-0.009342177,
-0.01000114,
0.0023750134,
0.063205555,
0.006582768,
0.029351322,
-0.0033703225,
0.025864307,
0.01982381,
0.01425008,
-0.007701633,
0.005034891,
0.01356366,
-0.012788005,
-0.0034149396,
0.010014868,
0.00418373,
-0.025013147,
-0.018739268,
-0.0013059141,
0.017215414,
-0.0077084973,
-0.0025431863,
-0.0006705466,
0.0003354878,
-0.025946679,
0.014304994,
-0.008731263,
0.0047088414,
-0.032783423,
-0.02335201,
0.028143222,
0.0113533875,
0.008491016,
-0.008950917,
0.027580358,
-0.016075958,
0.01975517,
-0.011792696,
-0.0018773589,
0.013666623,
-0.011435758,
-0.029296407,
-0.012039808,
-0.0073103737,
-0.0052511133,
-0.004121952,
0.015568007,
-0.017888106,
0.0039434833,
0.005412422,
0.016940847,
-0.016638823,
-0.0151561545,
-0.013748993,
0.0011231548,
-0.0018807909,
-0.0034526929,
-0.031630237,
-0.005477632,
-0.004454866,
0.0029996557,
0.02926895,
-0.013247907,
-0.009891313,
0.0427777,
0.0067372127,
0.027841197,
-0.012183956,
0.049037848,
0.008065435,
0.004173434,
-0.016268155,
0.027195962,
-0.0032296064,
-0.012087857,
0.04129503,
0.023763862,
-0.0143873645,
-0.0067131883,
0.0032965322,
-0.0031077669,
0.008642028,
-0.0097403005,
0.021498676,
0.015732747,
-0.0014251797,
-0.013364598,
-0.015403266,
-0.029351322,
0.022185097,
-0.014222624,
0.009280399,
-0.01279487,
0.020070922,
-0.010042326,
0.012836055,
0.0041665696,
0.010536548,
0.014634475,
-0.0027371,
-0.020839714,
-0.011380845,
-0.028280506,
0.025507368,
-0.0027268035,
0.011264153,
-0.0020952972,
-0.003734125,
0.007015213,
0.00616062,
0.007221139,
-0.00910193,
-0.009568696,
0.029873,
-0.01983754,
-0.011415166,
0.0048564216,
0.016268155,
0.022953887,
-0.010193338,
-0.007221139,
-0.017366428,
-0.021937985,
0.0035179027,
0.0039881007,
0.024573838,
0.00553941,
-0.026797839,
-0.008065435,
-0.017050674,
-0.01081798,
-0.013495018,
0.016391711,
-0.030339766,
-0.0007018645,
-0.008195856,
0.013096894,
0.02609769,
0.0025843715,
-0.014414821,
-0.012657586,
0.035693843,
-0.01802539,
0.017284056,
0.011209239,
-0.007025509,
-0.006984324,
0.015581735,
-0.004897607,
-0.031438038,
-0.020908354,
-0.030806532,
-0.04489187,
-0.014332451,
-0.025809394,
-0.005405558,
-0.0068607684,
0.013488154,
0.0049079033,
-0.036078237,
0.008312547,
-0.030861445,
-0.0035110386,
0.031438038,
-0.0066960277,
-0.0141951665,
0.02712732,
0.00003944234,
-0.0037581497,
0.0048392615,
-0.017750822,
-0.006067953,
0.00036852175,
-0.01931586,
0.0070426697,
0.009554967,
0.0036071374,
-0.0073035094,
-0.007914423,
-0.026125148,
-0.016487809,
0.02121038,
0.0064866696,
-0.014538377,
0.0065175584,
0.008044843,
0.010666967,
-0.02051023,
0.002222285,
-0.009410819,
-0.020812256,
0.008930325,
-0.020661244,
0.013337142,
-0.023736406,
0.022871517,
-0.015952403,
-0.023077441,
-0.030971272,
-0.0010553708,
-0.021526132,
-0.032948162,
-0.003802767,
-0.0025740752,
0.012609536,
-0.0027473962,
-0.015760204,
0.032151915,
-0.022088997,
0.036874484,
-0.023393195,
-0.004173434,
0.008388053,
-0.005625212,
0.015430722,
-0.013618574,
-0.022047812,
0.012513437,
0.03399152,
0.029296407,
-0.029214038,
0.016583908,
0.0051756073,
-0.0022548898,
-0.0067989905,
-0.0061228666,
0.027429346,
0.021443762,
0.0085871145,
-0.040196758,
-0.004145977,
0.031877346,
-0.0040258537,
0.0021296183,
-0.003631162,
-0.021841886,
0.009863856,
0.010934671,
-0.018560799,
-0.030888902,
0.034211174,
-0.012225141,
0.00905388,
0.03863172,
0.008278226,
0.021059368,
0.016254427,
-0.0149365,
-0.023132356,
0.006939707,
-0.026770381,
0.009376498,
-0.015403266,
-0.0102002015,
-0.016007315,
-0.019109935,
0.010550276,
-0.027525444,
-0.0006255003,
-0.0095481025,
0.005443311,
-0.0016190932,
0.014428549,
0.032069545,
-0.022391021,
-0.013213586,
0.00070400955,
-0.018217588,
-0.0021021613,
-0.010104103,
-0.021045638,
-0.012609536,
0.020551417,
0.015224797,
-0.010886622,
-0.017833194,
0.011367116,
0.008662621,
-0.023914874,
0.04093809,
0.16649805,
-0.019453144,
-0.008642028,
0.0472257,
0.0004985126,
-0.020084651,
-0.01879418,
0.0042008907,
-0.013618574,
0.028225593,
0.028170679,
0.002465964,
-0.017023217,
-0.0022188528,
0.0112366965,
0.015993588,
0.00014972537,
-0.0086283,
-0.00030352635,
0.0043862243,
0.010666967,
-0.0037787424,
-0.006668571,
-0.01073561,
0.035995867,
-0.0020575442,
-0.002743964,
0.0038508165,
-0.006404299,
0.013323413,
-0.0035487916,
0.0014500624,
0.010612054,
-0.001885939,
0.024107073,
0.0070701265,
0.0035522238,
-0.015815118,
0.011566178,
0.0027782852,
0.01802539,
0.004554397,
0.019961094,
-0.014153982,
-0.0026495813,
-0.0038061992,
0.0032673595,
-0.0018258773,
-0.009328448,
-0.0041150884,
-0.029296407,
0.019384502,
-0.006500398,
-0.002155359,
0.013062574,
-0.002085001,
0.002943026,
0.019219762,
-0.0008503028,
0.019508058,
-0.017805737,
0.031575322,
-0.016199512,
0.028253049,
-0.03047705,
-0.009486325,
-0.030806532,
-0.0035110386,
0.010907214,
-0.026111418,
0.0029052729,
-0.007907559,
-0.04286007,
-0.026509542,
-0.0008992103,
-0.008964646,
0.017297786,
0.013941191,
0.038933747,
0.019521786,
-0.012019215,
0.0036826436,
-0.031794976,
-0.021045638,
-0.022775417,
-0.03539182,
0.019137392,
-0.004207755,
-0.02472485,
0.0006422318,
0.011065091,
-0.021430034,
0.013886278,
0.0026821864,
0.0073172376,
0.013604845,
0.012678178,
-0.011435758,
-0.025273986,
-0.00034814366,
-0.02995537,
0.049312416,
-0.0029069888,
0.0056389407,
-0.010296301,
0.013632302,
-0.011923117,
0.008614572,
-0.0008254201,
0.0006061947,
0.0039091622,
-0.009005831,
0.0018293094,
-0.021773243,
-0.0073858798,
0.030449593,
0.031218383,
-0.0042146193,
0.025026875,
-0.0039331866,
-0.0147717595,
-0.028390333,
-0.0035728163,
0.00064480584,
-0.012691907,
-0.014840402,
-0.04335429,
0.012458524,
-0.007804596,
-0.033112902,
0.011325931,
0.00697746,
-0.0018876551,
0.00079195714,
-0.0060439287,
0.009465733,
0.0004860712,
-0.018039118,
-0.012520302,
0.011799561,
-0.0040910635,
0.015046327,
-0.004794644,
0.008882276,
0.0115044,
-0.01915112,
0.030284852,
0.012266327,
-0.013803907,
-0.014524648,
0.003118063,
0.0044377055,
-0.005649237,
0.0055977553,
0.029763173,
-0.03657246,
-0.030971272,
-0.028143222,
-0.010550276,
-0.0139274625,
-0.036023322,
-0.016693735,
0.018670626,
-0.012472252,
0.00418373,
0.0021931122,
-0.1751744,
-0.0019048157,
0.010330622,
-0.018299958,
0.031602778,
0.022857787,
0.0012750252,
0.026303615,
0.013096894,
-0.02833542,
0.043409202,
0.027292062,
-0.03940051,
-0.011991758,
0.007632991,
0.0032210262,
0.012801734,
0.022638133,
0.03022994,
-0.0029807792,
0.021169195,
-0.014909044,
0.01176524,
-0.023406923,
0.019604156,
0.025548555,
0.00029323006,
0.038604263,
-0.002222285,
-0.007866373,
-0.014483463,
-0.005553138,
0.021045638,
-0.0069362745,
0.0014208895,
0.022034084,
0.00042944154,
-0.010481634,
-0.0064180274,
0.006541583,
0.009349041,
0.011682869,
0.021649688,
-0.011833882,
-0.005192768,
-0.00038568227,
0.010564005,
-0.007234867,
0.017901834,
-0.015430722,
0.013742129,
-0.0047671874,
-0.012080993,
0.012286919,
-0.005336916,
0.03363458,
-0.004712274,
0.019357046,
-0.013687216,
-0.0065656076,
-0.010639511,
-0.018492157,
0.009568696,
-0.022706775,
0.0009841548,
-0.027058678,
-0.0105090905,
0.014565834,
-0.03701177,
0.011998623,
-0.026756654,
-0.0033565941,
0.00081340777,
0.004619607,
0.0015126981,
-0.0023098034,
-0.018423514,
0.0230088,
0.0014492043,
0.0062223976,
-0.015169883,
0.02704495,
-0.042118736,
0.022651862,
0.0011403153,
0.00871067,
0.0055977553,
-0.00093353126,
-0.017627267,
0.013742129,
0.015938673,
-0.01751744,
-0.009191165,
-0.0018104329,
0.012527166,
0.013982376,
0.0153483525,
0.0137352655,
-0.0102002015,
0.01073561,
0.0027800011,
0.013014524,
-0.0059032124,
0.04557829,
-0.00096442015,
0.016625093,
-0.01129161,
-0.019439416,
0.06688477,
-0.018711811,
-0.031218383,
-0.012513437,
0.0016491242,
0.016487809,
-0.0030974704,
0.023571664,
-0.0012355561,
-0.024065888,
0.01021393,
-0.002157075,
0.015787661,
0.0012235438,
-0.018519612,
0.017544897,
-0.00018822924,
-0.033716954,
-0.13607591,
-0.011696598,
-0.01107882,
0.024477739,
-0.015005142,
0.025370086,
0.0047397306,
0.022679318,
-0.0139274625,
0.031794976,
0.012939018,
-0.008291954,
-0.020318033,
-0.018396057,
0.031904805,
-0.01862944,
-0.011566178,
-0.023544207,
-0.005316323,
0.0027817173,
0.013700944,
-0.016611366,
0.0003863258,
0.008724399,
0.012341833,
0.009685387,
-0.016487809,
0.027319517,
0.01385882,
0.011456351,
0.04552338,
-0.021704601,
0.015101241,
-0.021402577,
-0.011023906,
-0.0076261265,
-0.007777139,
-0.011552449,
0.02549364,
-0.0064832373,
-0.01854707,
0.010056053,
0.030257396,
0.0010871177,
0.010962128,
0.0024814084,
-0.008456695,
0.019343317,
-0.03014757,
-0.015087512,
-0.020208206,
-0.01034435,
-0.04121266,
0.017901834,
0.024848405,
-0.014991414,
0.016542723,
0.021732058,
-0.029653346,
-0.025452456,
-0.012691907,
0.010824844,
-0.023914874,
0.014552105,
-0.013549931,
-0.018711811,
-0.0131586725,
-0.013234179,
0.009204892,
-0.04549592,
-0.0007456238,
0.023118626,
-0.0061365953,
-0.009403954,
-0.034046434,
0.018945193,
-0.016885933,
-0.016364254,
-0.006188077,
-0.01982381,
0.0010287721,
-0.023200998,
0.013206721,
-0.016583908,
0.0036380263,
0.010316893,
-0.0051103975,
0.0151561545,
-0.01630934,
-0.01699576,
-0.024107073,
0.028033394,
0.0049181995,
0.0014183155,
0.013920599,
0.012458524,
-0.012211412,
0.0009326732,
0.018039118,
-0.009678523,
-0.001095698,
-0.012781141,
-0.05074017,
0.012177092,
0.002157075,
-0.0004732008,
0.0059615583,
-0.026797839,
-0.0015152723,
-0.0039949645,
0.011470079,
0.051316764,
-0.007543756,
0.040800806,
-0.000650812,
-0.019274674,
-0.022816602,
-0.01673492,
0.02722342,
0.013707808,
0.015842576,
-0.008408645,
-0.015252253,
-0.012437931,
0.022006627,
0.019164847,
-0.026083961,
0.009225486,
-0.0070426697,
0.035748757,
-0.0063871387,
-0.018588254,
0.01709186,
-0.011751511,
-0.00321931,
-0.0018207292,
-0.009177436,
-0.008902868,
0.004111656,
0.010426721,
0.005573731,
0.0540899,
-0.0056904224,
-0.025699567,
0.003317125,
0.004207755,
-0.009685387,
-0.0031335074,
-0.011113141,
-0.017750822,
-0.0059066447,
-0.00849788,
0.041816708,
0.021416305,
-0.0026787543,
-0.028143222,
-0.0035213348,
0.0052922987,
-0.012540895,
0.017476255,
0.004310718,
-0.011147462,
0.021416305,
0.03632535,
0.029708259,
-0.009012695,
0.004108224,
0.014922772,
-0.012170227,
0.0025826555,
0.02841779,
-0.04969681,
-0.024107073,
-0.015293439,
0.00923235,
0.016364254,
-0.0040876316,
-0.040636066,
-0.019288404,
0.005508521,
0.0011385992,
0.027415616,
0.018231317,
0.008992103,
-0.022775417,
0.016556451,
0.021004453,
0.0015195623,
0.006877929,
0.0119299805,
0.0003118921,
-0.0058688913,
-0.008532201,
0.021416305,
0.027690185,
0.0030408408,
-0.0037924708,
0.030779075,
0.020057194,
0.006630818,
-0.0005036607,
0.006754373,
-0.012719364,
0.00854593,
0.0009841548,
-0.031136014,
-0.003960644,
0.010920943,
-0.0041597057,
-0.030120112,
0.0021742354,
0.019727712,
0.0068264473,
-0.0043278784,
-0.005714447,
-0.0043965206,
-0.00424894,
0.031712607,
-0.027497986,
-0.03649009,
-0.014950229,
-0.0029001248,
0.012238869,
0.024669936,
-0.0012449943,
0.007262324,
0.050932366,
0.012067265,
0.04659419,
-0.006105706,
0.028047124,
-0.0020352355,
0.012266327,
-0.010612054,
-0.029351322,
-0.013035117,
-0.015924945,
0.013893141,
0.0019030996,
0.006720052,
-0.00678183,
0.06853218,
0.03484268,
0.00024432264,
0.020043466,
-0.008621436,
0.035995867,
0.023310825,
0.016899662,
0.007152497,
-0.0011051362,
0.038164955,
-0.007090719,
0.03014757,
-0.040443867,
-0.0028383469,
-0.015691562,
-0.008058571,
0.024738578,
-0.0049284957,
-0.0017023217,
0.012561487,
-0.011195511,
0.019810082,
0.024930777,
-0.042201106,
0.0000123475165,
0.0161446,
-0.027168505,
-0.0026856184,
-0.045386095,
0.0068847933,
0.013076302,
-0.023503022,
-0.01606223,
0.0037512856,
0.003181557,
-0.007859509,
-0.021333935,
0.017792007,
0.033277646,
0.0028640877,
-0.00061606197,
-0.026317345,
-0.02979063,
-0.03322273,
0.008717535,
0.0024693962,
-0.02413453,
0.0004487471
] |
Stem cells persist throughout life in diverse tissues by undergoing self-renewing divisions. Self-renewal capacity declines with age, partly because of increasing expression of the tumor suppressor p16(Ink4a). We discovered that the Hmga2 transcriptional regulator is highly expressed in fetal neural stem cells but that expression declines with age. This decrease is partly caused by the increasing expression of let-7b microRNA, which is known to target HMGA2. Hmga2-deficient mice show reduced stem cell numbers and self-renewal throughout the central and peripheral nervous systems of fetal and young-adult mice but not | [
-0.01494394,
-0.011064012,
-0.0025402736,
-0.024849862,
-0.024156315,
0.013327848,
-0.03472961,
0.016344117,
-0.016906803,
-0.013439077,
0.019340755,
-0.00631388,
-0.00019955786,
-0.0048221033,
-0.021617679,
0.00008153043,
0.03452024,
0.012143587,
0.0013715514,
0.011391155,
-0.0048221033,
0.019550128,
-0.013949422,
-0.018882753,
-0.028919533,
0.01726012,
0.025530322,
-0.03609053,
0.009251634,
-0.026537925,
0.021696193,
0.0064970804,
-0.010010608,
-0.0011261933,
-0.008931032,
-0.0031602115,
0.0019923071,
-0.033080805,
0.024051629,
0.0017960208,
0.011960386,
0.013465249,
-0.008872147,
-0.0029148534,
-0.004462245,
-0.0031307684,
-0.007144826,
-0.008217858,
-0.0058591496,
0.04532908,
-0.0041187434,
-0.010187265,
-0.0017927494,
0.0062091937,
-0.027244555,
0.004063129,
-0.00041261042,
0.022494424,
-0.013504506,
-0.0044328016,
0.0076813423,
-0.011659414,
-0.013700793,
0.018594867,
0.0008898318,
0.009709635,
-0.005319362,
0.015572056,
0.0200343,
-0.014629882,
0.025582664,
0.011796814,
-0.02180088,
-0.007753314,
-0.009663835,
-0.012065073,
-0.02575278,
-0.0025419092,
-0.0052179475,
-0.0071186544,
0.02136905,
-0.012117416,
0.0028068959,
0.024692832,
0.014813082,
0.009487177,
-0.0050838185,
0.0071055684,
0.018568696,
0.0030849683,
0.027296899,
0.019877272,
0.0076028276,
0.01864721,
-0.003938814,
-0.0023767014,
0.002875596,
0.01932767,
0.0009045533,
-0.0043902732,
-0.024038544,
0.0049529606,
-0.0007242151,
-0.016893718,
-0.02182705,
-0.006804596,
0.019811843,
0.0027038455,
-0.008760917,
-0.00472396,
-0.0196679,
0.017181605,
-0.0017322277,
-0.036195215,
0.009114233,
0.006356409,
0.024627404,
0.006320423,
-0.0069027394,
0.005986736,
0.011260298,
0.022926254,
0.016422631,
-0.03349955,
0.009873207,
0.036797162,
-0.00006450871,
0.0024339517,
-0.03452024,
0.00708594,
0.009375948,
-0.014472852,
0.0021493363,
0.0019628643,
-0.015689828,
0.0044851447,
-0.008760917,
-0.019262241,
-0.009683464,
-0.043680273,
0.0018189208,
0.01673669,
-0.021892479,
-0.0023767014,
0.00024249552,
0.00021468828,
0.02377683,
-0.0021493363,
0.020610075,
0.010383552,
-0.009088062,
-0.017312463,
0.026603354,
-0.023057112,
-0.00048826248,
0.0018172852,
0.015637485,
0.022271967,
-0.023593629,
-0.01494394,
0.011921129,
0.0053455336,
0.022952426,
0.010939697,
-0.006660653,
0.03347338,
-0.017966751,
0.019013612,
0.0009143676,
-0.00926472,
0.0025206448,
0.028291417,
-0.032949947,
-0.0023685228,
-0.015074797,
0.002379973,
-0.01932767,
0.017338634,
-0.03711122,
-0.025098491,
-0.015493542,
0.033761267,
0.011404241,
0.0029851894,
-0.009428292,
0.007027054,
0.025661178,
-0.004367373,
0.0066802814,
0.0019628643,
-0.028474618,
0.008891775,
0.01426348,
-0.010507867,
-0.6398414,
-0.019262241,
0.01435508,
0.0028101674,
0.018686468,
0.016854461,
0.0053455336,
-0.0041285576,
-0.04640211,
0.014642967,
-0.0021738722,
0.026354725,
0.0006743257,
-0.014472852,
-0.010377009,
-0.027767986,
-0.010874268,
-0.02575278,
0.021997165,
0.0009184569,
-0.012398759,
0.0033483193,
-0.0024355873,
0.014394338,
0.0038504854,
0.01726012,
0.03041131,
-0.011384613,
0.0036280274,
0.04344473,
-0.01784898,
0.019288413,
-0.016632004,
0.010049865,
0.051557902,
0.012235187,
-0.0060783364,
0.023868429,
-0.009232005,
0.028762504,
-0.010933154,
0.010475152,
0.028657818,
-0.014865425,
-0.016959148,
0.013295134,
-0.0036574705,
0.0000060828347,
0.021041906,
-0.0063106087,
-0.0046160026,
0.013138104,
-0.005296462,
-0.012483817,
0.01503554,
0.013910165,
0.009748893,
0.0006669649,
0.004933332,
-0.002818346,
0.01737789,
0.03954517,
-0.0018859854,
0.000120634366,
-0.006663924,
0.012424931,
-0.015925372,
0.0097946925,
0.009526434,
-0.011325726,
0.0070663113,
0.025556492,
-0.02071476,
0.0033663122,
0.034677267,
0.020570816,
-0.012326787,
-0.009225462,
0.00020466949,
0.01435508,
0.0058198925,
-0.008191687,
-0.014930854,
0.017613435,
0.014394338,
-0.0057675494,
-0.027689472,
0.009519892,
-0.026564097,
0.020662418,
0.0045113163,
-0.0018778068,
0.004167815,
-0.049699724,
-0.013661535,
0.015114055,
-0.004985675,
0.013478334,
0.005142704,
-0.024601232,
-0.0077075134,
-0.00029811,
0.01657966,
-0.0032060116,
0.0061535793,
0.02713987,
-0.05066807,
-0.0025173733,
0.01941927,
-0.02043996,
0.0013977229,
0.01651423,
-0.012568874,
-0.0038210424,
-0.0038439424,
-0.021172762,
0.008715117,
-0.001450066,
-0.015506628,
-0.01682829,
0.009035719,
0.0029148534,
0.0076028276,
0.006915825,
0.01880424,
0.012176301,
0.0087674605,
0.0044360734,
0.005898407,
-0.008433773,
-0.009500263,
-0.0058264355,
0.02868399,
-0.036299903,
0.043313872,
-0.0030473468,
0.01417188,
0.007406541,
0.029495306,
-0.015768344,
-0.03349955,
-0.0029851894,
0.01383165,
-0.0039846143,
-0.010952783,
-0.022062594,
-0.009474091,
-0.0062124655,
0.024732089,
-0.007786028,
-0.019537043,
0.0026318738,
-0.010187265,
0.015781429,
0.010291952,
-0.016383374,
-0.003932271,
-0.015048626,
0.01401485,
-0.01614783,
-0.022402825,
0.035148356,
-0.0037556137,
0.0023668872,
-0.015140226,
0.002764367,
-0.025046147,
0.02321414,
0.0013257512,
-0.021970993,
-0.021512993,
-0.010206894,
0.010291952,
0.00279381,
0.012771703,
0.0017862065,
0.0002420866,
0.0043510157,
-0.028945705,
-0.012915647,
-0.0027529171,
-0.032217145,
0.009964808,
-0.010776125,
0.043209184,
0.024182487,
0.0062288227,
0.0017485849,
0.01069761,
0.009349776,
-0.013465249,
0.024627404,
-0.014132623,
0.021421392,
-0.00037969154,
-0.046375938,
0.006693367,
-0.010004065,
0.019890357,
0.040251803,
-0.0056923064,
-0.023240313,
-0.006506895,
0.00277091,
0.016461888,
-0.020138986,
-0.022010252,
-0.016854461,
0.0054175053,
0.009690006,
-0.0009716178,
0.0036967276,
-0.012667017,
-0.004880989,
0.007962686,
-0.01031158,
-0.01494394,
-0.0047893887,
-0.0018320066,
-0.008309458,
-0.0021787793,
0.008610431,
0.0042168866,
-0.0024404945,
0.020426873,
0.008774003,
0.00949372,
0.0028886818,
-0.0003760112,
-0.00556472,
0.004040229,
0.023855343,
0.010422809,
0.013949422,
0.009179662,
0.009029175,
0.010534038,
-0.004658531,
0.03828894,
0.003788328,
0.01335402,
-0.0056792204,
0.0004800839,
-0.0023129084,
-0.0067326245,
-0.028291417,
0.029102733,
-0.018673383,
-0.011567813,
0.012882932,
-0.031379655,
0.0058787786,
-0.0013453799,
0.0029017676,
0.003987886,
-0.017050747,
-0.0014606981,
0.00010417493,
0.010677981,
0.016213259,
0.02028293,
-0.0065952237,
-0.01701149,
-0.019484699,
0.0026236952,
0.009408663,
0.015545885,
0.0067260815,
-0.018176123,
-0.00978815,
-0.009775064,
0.00018217834,
0.020479217,
-0.030332796,
0.015336513,
0.0099975215,
0.028945705,
0.0040533147,
0.005898407,
0.015585142,
-0.010592924,
-0.03488664,
0.034232352,
0.017940579,
-0.012222101,
-0.008590803,
0.0034153839,
-0.018764982,
-0.006752253,
-0.0068503963,
0.010494781,
0.0012766796,
0.0033532265,
0.006500352,
-0.024784433,
0.0037098133,
0.0072037117,
-0.013072676,
0.00987975,
0.0061633936,
-0.0043019443,
-0.0050412896,
-0.016985318,
0.003935543,
0.022428995,
0.007851457,
0.0017600349,
0.0054273196,
-0.011829529,
-0.008616974,
-0.013870907,
-0.021905566,
0.013897079,
0.003245269,
0.003572413,
0.005800264,
0.032845262,
-0.014250394,
0.019105213,
0.0053815194,
-0.0116725,
-0.015663657,
0.0015506628,
-0.013340934,
0.04522439,
0.026420152,
-0.015179483,
0.00583625,
0.002834703,
0.005636692,
-0.0041710865,
-0.012176301,
0.010134922,
-0.024941461,
0.0110247545,
-0.011064012,
0.000356587,
-0.023449685,
0.01315119,
0.022271967,
0.0023423512,
-0.017364806,
-0.03470344,
0.01701149,
-0.0083879735,
0.006271351,
0.022337396,
0.053049676,
0.023017855,
0.0075897416,
0.015166398,
0.010076037,
0.0011270113,
-0.006500352,
0.0026253308,
0.011338812,
0.004858089,
0.016121658,
0.0038177709,
-0.026223866,
0.010383552,
0.0016447167,
0.007229883,
-0.017521834,
0.022690712,
0.027349241,
0.010749953,
0.0048744464,
0.0033924838,
-0.0024274087,
-0.015454285,
0.0072822263,
-0.017705036,
-0.024535803,
0.013818564,
-0.02939062,
-0.0076028276,
-0.005316091,
0.011378069,
0.0020790005,
-0.0021035362,
-0.016474973,
-0.0035102556,
-0.0197595,
0.001678249,
-0.031065598,
0.029626165,
-0.01726012,
-0.009408663,
-0.0025435449,
0.013138104,
-0.010632182,
-0.019026697,
-0.0035233414,
0.01852944,
-0.01737789,
-0.04655914,
0.005008575,
0.006438195,
0.030960912,
0.015506628,
-0.009572235,
-0.016802117,
0.015873028,
0.01262776,
-0.041534208,
-0.01035738,
-0.01889584,
0.014564453,
-0.010795753,
0.0015073161,
-0.020832533,
-0.022101851,
-0.010638724,
0.0200343,
-0.0071121114,
0.025569579,
-0.0054633054,
-0.011358441,
0.013975593,
0.035828814,
0.00640548,
-0.013367105,
0.0005074822,
-0.0047828457,
-0.03661396,
-0.0357503,
-0.025294777,
-0.01744332,
-0.012137044,
0.0033990266,
0.0031127755,
-0.020426873,
-0.029940223,
0.0029361178,
-0.003197833,
0.0052572046,
-0.010344295,
0.00978815,
0.0021820508,
0.009513348,
0.008800175,
0.006225551,
0.0019186998,
-0.0078121996,
-0.019314583,
0.031353485,
0.009068433,
-0.00872166,
0.005754464,
0.008217858,
0.0009847035,
-0.027794158,
0.004851546,
0.018516352,
0.05344225,
-0.020296017,
-0.032557376,
-0.02432643,
-0.027270727,
-0.0011769007,
0.010514409,
0.017482577,
-0.017233947,
-0.00872166,
0.012006186,
-0.0044786017,
-0.03093474,
0.025491064,
-0.029181248,
-0.0047861175,
0.020178244,
0.014930854,
0.0124445595,
0.0073869126,
0.020361446,
-0.0047828457,
0.006366223,
-0.006928911,
-0.041508038,
0.018869668,
-0.006097965,
0.028579304,
0.025713522,
0.04867903,
0.0158076,
-0.004714146,
0.01744332,
0.0070663113,
0.014839253,
-0.008093543,
0.0511915,
-0.002677674,
0.017090004,
-0.0073345695,
0.01614783,
0.020662418,
-0.027977359,
0.020701675,
0.011731385,
-0.01451211,
-0.0024993804,
0.015074797,
-0.037686992,
-0.046454452,
0.001812378,
-0.041141633,
0.013661535,
-0.038210426,
-0.0006951811,
0.023253398,
0.0041710865,
0.0057839067,
0.0068831104,
0.011829529,
-0.015271083,
0.026040666,
0.001186715,
-0.0068896534,
0.008551545,
-0.012385674,
0.00354297,
-0.01821538,
0.02182705,
0.0060717934,
0.008649688,
-0.00010540172,
-0.027113698,
0.012091244,
0.0047337743,
-0.023083283,
-0.025307862,
-0.022285052,
-0.029599993,
-0.020466132,
-0.011646328,
-0.035907328,
-0.010592924,
-0.013085762,
-0.00867586,
-0.016474973,
0.025373291,
0.0038079566,
-0.023423513,
0.021382134,
-0.00915349,
0.022677625,
-0.0038504854,
0.016160917,
0.019589385,
0.016985318,
-0.027349241,
-0.01892201,
-0.008944118,
-0.0013494692,
0.040304147,
0.007858,
-0.0067718816,
-0.02920742,
0.014970112,
0.016291773,
-0.005921307,
-0.032243315,
0.0070335967,
0.00847303,
-0.008302916,
0.006582138,
-0.009029175,
-0.03711122,
-0.004076215,
0.0043804585,
0.033735093,
-0.012496903,
-0.013897079,
-0.019798758,
0.012091244,
0.0030587967,
-0.0032518117,
0.014472852,
0.005051104,
-0.013818564,
-0.013988679,
0.004756674,
-0.004004243,
-0.008355259,
0.050196983,
-0.037713166,
0.0030767897,
0.026851984,
-0.022520596,
-0.011574356,
0.0062648086,
-0.005891864,
0.03438938,
-0.03004491,
-0.021015733,
0.011718299,
0.0080412,
-0.002918125,
0.0002619197,
-0.0025451807,
0.00556472,
-0.032086287,
-0.0007945511,
0.024588145,
0.016317945,
-0.0049137035,
-0.0008407602,
-0.04467479,
-0.015362685,
-0.03145817,
-0.035645615,
0.009618035,
-0.04755366,
-0.0238946,
0.013517592,
0.021813964,
0.020544646,
-0.018202294,
-0.0007434348,
-0.009945178,
0.037372936,
-0.013543763,
0.036038186,
0.0004956232,
0.0034775413,
-0.010723782,
0.011391155,
-0.0016103665,
-0.036012016,
-0.0038079566,
-0.011476213,
-0.020269845,
0.0054633054,
-0.002852696,
0.029809365,
0.0010525859,
-0.0042070723,
-0.010285408,
0.0035691415,
0.016789032,
0.00083462626,
0.0029622894,
0.0057675494,
-0.021159677,
0.008728203,
-0.0010746681,
-0.0061110505,
-0.005051104,
-0.011135983,
-0.01253616,
0.009860122,
-0.0075962846,
-0.004203801,
-0.010723782,
0.0012202472,
-0.0056955777,
-0.0015522984,
0.001607913,
-0.009330148,
-0.021905566,
0.016226344,
-0.00890486,
-0.0028330674,
-0.019654814,
0.021290533,
0.017181605,
0.011103269,
-0.016972233,
0.010233066,
-0.0014181695,
-0.02645941,
-0.035985846,
0.010880811,
-0.0076747993,
0.022808483,
0.023593629,
-0.003631299,
-0.0073411125,
0.007295312,
-0.04653297,
-0.03127497,
0.016527317,
0.020243673,
-0.000672281,
0.03347338,
-0.021133505,
-0.0059769214,
-0.0044851447,
0.018686468,
-0.001812378,
-0.01830698,
0.0073345695,
-0.015716,
0.0037163564,
0.015009369,
-0.02559575,
-0.02902422,
0.010756496,
-0.00020998558,
-0.01701149,
0.013517592,
-0.016461888,
0.027296899,
0.00049439643,
0.013556849,
0.023397341,
0.024483461,
0.008760917,
-0.012228644,
-0.0081589725,
0.0033335977,
-0.004674888,
-0.017914407,
0.007308398,
-0.0020969934,
-0.002566445,
-0.0031585756,
-0.015323427,
-0.007092483,
0.014957026,
-0.008250573,
0.040696718,
0.019052869,
0.01262776,
0.0235282,
0.019720243,
0.0022605653,
0.000806819,
0.0049202465,
-0.008486116,
-0.012424931,
0.005008575,
-0.0049104323,
-0.027035184,
-0.022337396,
-0.015977714,
-0.030856226,
-0.0039911573,
0.009559149,
-0.020570816,
-0.03109177,
0.026263123,
-0.01435508,
-0.01358302,
-0.011908043,
-0.008944118,
0.0079496,
-0.01358302,
0.008819804,
-0.021473736,
-0.0009789786,
-0.008512288,
-0.00085139234,
0.005492748,
0.00021775525,
-0.0031912902,
-0.00034247892,
0.006137222,
0.020348359,
0.19691454,
-0.008976832,
0.000010434106,
-0.00095198915,
0.012856761,
0.0035691415,
0.032321833,
-0.008597345,
-0.0065167095,
0.0029442965,
-0.002244208,
0.009958264,
-0.019523956,
-0.0024813875,
0.030542167,
-0.031484343,
-0.028396104,
-0.00088737824,
-0.03266206,
-0.021015733,
0.012595045,
-0.015048626,
0.01565057,
-0.015676742,
0.020400703,
-0.015886115,
-0.027584786,
0.012483817,
0.013988679,
-0.011319184,
-0.03195543,
0.016435716,
-0.010723782,
-0.00024310891,
0.0019383285,
0.00944792,
-0.018660296,
0.001134372,
0.0006240273,
0.00057536457,
0.0007851457,
0.01392325,
-0.0148915965,
0.029155077,
-0.0028330674,
0.029992566,
0.00033511818,
-0.000019909781,
-0.00983395,
-0.021107333,
-0.054698482,
0.010789211,
0.013910165,
0.026511753,
-0.011535099,
-0.00093808555,
-0.0009838857,
0.00626808,
-0.007360741,
0.019654814,
-0.018817326,
-0.005875507,
-0.030489825,
0.005060918,
-0.0037327134,
0.034965154,
-0.020806361,
-0.00015825593,
0.00002361571,
-0.026603354,
0.010776125,
0.010069493,
-0.025569579,
0.00863006,
-0.016802117,
-0.01852944,
0.0325312,
0.019694071,
0.0077663995,
0.0063793086,
0.010331209,
0.0025697164,
-0.027741814,
0.0003490218,
-0.0071055684,
-0.041612722,
0.014250394,
0.028186731,
-0.005237576,
-0.038236596,
0.020296017,
-0.016213259,
-0.0051590614,
0.0036345704,
-0.016867546,
-0.006575595,
0.0024225016,
0.021277448,
-0.006448009,
-0.0073738266,
-0.038943227,
0.061921824,
-0.0022393009,
0.018254638,
0.012640846,
0.013648449,
-0.0031503972,
0.0054109623,
-0.036849506,
-0.01623943,
0.0064643663,
-0.03229566,
0.01103784,
-0.006438195,
-0.0069550825,
0.025648093,
0.010448981,
-0.0029328463,
0.04501502,
-0.020086644,
0.000067524576,
-0.004426259,
0.011894957,
0.025216263,
-0.011888415,
0.0018974354,
-0.026472496,
-0.0104162665,
-0.013425992,
-0.03569796,
-0.015519713,
-0.01339982,
0.01787515,
0.012150129,
0.018751897,
-0.010324666,
-0.001040318,
-0.00092745334,
-0.020544646,
0.027218385,
-0.020479217,
-0.016645089,
0.0036083988,
0.008774003,
-0.002420866,
-0.02902422,
0.02568735,
0.027689472,
-0.01630486,
-0.026328553,
-0.007923429,
-0.033708923,
-0.0026106094,
-0.0059834644,
0.02800353,
-0.00631388,
-0.027794158,
-0.026603354,
0.0067653386,
0.0052473904,
-0.022572938,
0.033185493,
-0.012869847,
-0.0041939868,
-0.0063236943,
-0.0047370456,
-0.16393842,
-0.015323427,
0.014525196,
-0.04519822,
0.023541285,
0.021879394,
0.0062419083,
-0.011659414,
-0.0052539334,
0.028553132,
0.033080805,
0.0014304373,
-0.04472713,
-0.03433704,
0.011476213,
0.004413173,
0.0106190955,
0.03705888,
0.033080805,
0.0057773637,
0.032871433,
-0.0037196279,
0.013517592,
-0.0017583992,
-0.0069812536,
0.0050249323,
0.003291069,
-0.0048384606,
-0.009232005,
-0.004710874,
-0.019864187,
-0.0022474795,
0.0274801,
0.0011801721,
-0.002186958,
-0.008734746,
-0.0011613613,
-0.003654199,
0.0048155603,
0.025046147,
0.005244119,
0.031510513,
0.012778246,
0.0003471816,
0.0008448495,
0.046506796,
-0.019105213,
-0.0038897425,
0.038733855,
-0.013949422,
0.04381113,
-0.010599467,
0.013210076,
0.019458527,
0.034153838,
0.008270201,
0.011364984,
0.012313702,
0.0015195841,
0.0015972807,
-0.0008898318,
0.0014688767,
0.029783193,
0.0059998217,
0.026825812,
-0.03213863,
0.0007119472,
0.013288591,
-0.028971877,
0.0028314316,
-0.027218385,
-0.013386734,
0.009009547,
-0.0278465,
0.039623685,
0.0034284696,
0.00020415832,
-0.00358877,
-0.0010951146,
0.017207777,
-0.016252516,
0.01907904,
-0.03784402,
-0.018241553,
0.000081428196,
0.0054731197,
0.027401585,
0.018241553,
-0.015977714,
-0.0036672847,
0.026420152,
-0.0042528724,
0.0078121996,
0.0039911573,
0.021251276,
0.02191865,
-0.003454641,
-0.014184966,
0.001531852,
0.0027349242,
0.01855561,
-0.017181605,
-0.010579838,
-0.008021572,
0.04017329,
-0.0045669307,
-0.022756139,
0.028631646,
0.04501502,
-0.004449159,
0.011410784,
0.007347655,
0.0014541553,
0.01769195,
0.009519892,
0.025268605,
0.003395755,
-0.0068569393,
-0.0060816077,
-0.027610958,
0.06375383,
0.002121529,
-0.005325905,
0.027532442,
0.020243673,
-0.026930498,
-0.12604205,
-0.03111794,
-0.0011286469,
-0.00087511033,
-0.025661178,
0.014368166,
-0.009140405,
0.018830411,
-0.016016971,
0.027584786,
-0.022834655,
-0.01812378,
-0.0132689625,
-0.013275505,
0.019222984,
-0.0053847907,
0.0012848582,
0.005231033,
-0.015428113,
0.034127668,
-0.013275505,
0.015716,
0.0003128315,
-0.015938457,
-0.005669406,
0.013556849,
-0.040251803,
0.020165158,
0.029914051,
0.016344117,
-0.00026846258,
-0.00029074927,
0.015388856,
0.007694428,
-0.019864187,
-0.022481339,
0.0051001757,
-0.023632886,
0.030620683,
-0.030306624,
0.0053389906,
0.005705392,
0.02713987,
0.0037490707,
0.012130501,
-0.022036422,
-0.0162656,
0.00058477,
0.01401485,
-0.03140583,
-0.055012543,
-0.021212019,
-0.015441199,
-0.012595045,
0.026485581,
-0.0032828904,
0.02414323,
0.007864542,
-0.00558762,
0.00010897986,
0.017220862,
0.010475152,
-0.018503267,
-0.0058493353,
0.02009973,
-0.029259764,
-0.03745145,
-0.031039426,
0.021565335,
-0.025425635,
0.0039257286,
-0.003279619,
0.003699999,
-0.015349599,
-0.023318827,
0.016278688,
-0.01694606,
-0.00901609,
0.0083748875,
-0.009415206,
-0.0019268784,
-0.016906803,
0.0058493353,
-0.010756496,
0.027427757,
-0.0076813423,
0.014525196,
-0.025805121,
0.006097965,
0.003929,
0.014499024,
0.04826029,
-0.009336691,
-0.022729969,
-0.0014108086,
0.03130114,
-0.0036738275,
0.0019415999,
0.0116201565,
0.006101236,
-0.0019514142,
-0.02482369,
-0.055117227,
0.0013764586,
-0.009258176,
0.006150308,
-0.0019007069,
-0.017142348,
0.01417188,
-0.0043346584,
-0.0028461532,
-0.007982315,
-0.0034415552,
0.0032730761,
-0.01694606,
-0.008898318,
-0.022180365,
-0.01521874,
0.02191865,
-0.0044458876,
0.008715117,
0.024064716,
0.0010223251,
0.010023694,
-0.005705392,
0.0028085315,
0.010161094,
-0.010056408,
-0.02096339,
0.016605832,
0.004848275,
0.013988679,
-0.0013846372,
-0.04017329,
-0.0013044869,
0.007295312,
0.00006425314,
-0.025294777,
0.015519713,
0.03818425,
0.01630486,
0.017639607,
-0.024928376,
-0.027035184,
0.017430235,
0.0148915965,
0.005548363,
0.010350837,
-0.033316348,
-0.011463127,
0.00474686,
-0.0030669754,
0.05412271,
0.011921129,
0.009958264,
-0.029442964,
-0.011489299,
-0.013517592,
-0.013465249,
0.0018009279,
-0.002461759,
0.0015678378,
0.0011302826,
-0.0008264476,
-0.000022427257,
0.00037212635,
-0.00833563,
-0.015925372,
-0.020492302,
0.0071055684,
-0.006438195,
-0.032007772,
-0.02293934,
0.0056955777,
0.020754019,
-0.0049038893,
0.01605623,
0.012948361,
-0.030646853,
-0.00077246886,
-0.037634652,
0.031248799,
0.014852339,
-0.0072037117,
-0.005371705,
0.012961447,
0.039388143,
-0.002893589,
0.0032943406,
0.019118298,
0.02259911,
-0.016003886,
-0.0039617145,
0.006418566,
0.028291417,
0.0018745353,
-0.004524402,
0.043523245,
-0.014760739,
0.011273384,
-0.014328909,
0.036169045,
0.01237913,
0.0020070288,
-0.0040467717,
-0.019065954,
0.009421748,
0.03211246,
-0.021028819,
-0.025661178,
0.0028445174,
0.0003336869,
0.012424931,
0.01108364,
-0.010677981,
-0.0049006175,
-0.009271262,
0.0032567189,
-0.00016234523,
-0.009598406,
-0.006271351,
0.046820857,
0.01435508,
0.0087805465,
-0.0005213858,
-0.017116176,
0.015912287,
0.008302916,
0.027898844,
-0.023122542,
0.017731206,
-0.026393982,
0.022088766,
0.0035331557,
-0.03449407,
-0.014773825,
0.00674571,
-0.008787089,
0.0031667543,
0.026289295,
-0.021460649,
0.07945675,
-0.004583288,
-0.025386378,
0.011744471,
-0.015506628,
0.015624399,
-0.0033630407,
0.008015029,
-0.03928346,
-0.012071615,
0.01898744,
-0.043366212,
0.019288413,
-0.030777711,
-0.010854639,
0.033106975,
-0.019026697,
0.0075504845,
-0.00115809,
0.002746374,
0.020780189,
-0.02337117,
-0.0030800612,
0.0050347466,
-0.044779476,
0.007792571,
0.0436541,
-0.011044383,
0.004056586,
-0.0118098995,
0.0162656,
0.005829707,
-0.05443677,
-0.014328909,
0.013622277,
-0.014054108,
-0.016566575,
-0.03250503,
0.005191776,
0.028657818,
-0.0024535803,
0.00992555,
-0.007910343,
-0.0158992,
0.006578867,
-0.013936336,
-0.013543763,
-0.0065919524,
-0.0007638813
] |
Somatic stem cell depletion due to the accumulation of DNA damage has been implicated in the appearance of aging-related phenotypes. Hair graying, a typical sign of aging in mammals, is caused by the incomplete maintenance of melanocyte stem cells (MSCs) with age. Here, we report that irreparable DNA damage, as caused by ionizing radiation, abrogates renewal of MSCs in mice. Surprisingly, the DNA-damage response triggers MSC differentiation into mature melanocytes in the niche, rather than inducing their apoptosis or senescence. The resulting MSC depletion leads to irreversible hair graying. Furthermore, deficiency of Ataxia | [
-0.0052897665,
-0.013326522,
0.006050623,
-0.044478834,
-0.03976218,
0.016903536,
-0.019301388,
0.00686418,
-0.009005119,
-0.008702094,
0.014663786,
0.019551715,
0.0063240044,
0.011745521,
-0.0009255444,
0.005576323,
0.045190282,
0.008208031,
0.0030566023,
0.009413544,
-0.032331474,
0.017430538,
0.0036363027,
-0.0045651407,
0.015651911,
0.0061955485,
-0.0024357298,
-0.051619686,
-0.008926069,
0.011165821,
0.0021639953,
-0.013267235,
0.0033233962,
-0.014782361,
-0.019788865,
0.014136786,
0.010948433,
-0.02959107,
0.0037351153,
-0.030460622,
-0.012121009,
-0.002885327,
-0.0098944325,
-0.007931355,
0.004199534,
0.014242185,
-0.018958839,
-0.02114589,
-0.0061362605,
0.0073977676,
0.033385474,
0.0021705828,
-0.02217354,
-0.010579533,
-0.0007324482,
-0.02064524,
0.009182981,
0.023464693,
0.008478119,
0.008148744,
0.0035440775,
0.00783913,
-0.014690136,
0.011271221,
-0.009341082,
0.01370201,
0.0069761677,
-0.012779759,
-0.0039162715,
-0.020487139,
0.04131683,
0.011165821,
0.004723241,
-0.011363446,
0.005770654,
-0.023398817,
-0.019841565,
0.0033728024,
0.015151261,
0.0011701055,
0.02924852,
0.0037186465,
-0.0021837577,
0.019762514,
0.012437209,
0.018774388,
-0.02017094,
0.012529434,
0.017087987,
0.012904922,
0.015059036,
0.019670289,
0.0133133475,
0.02135669,
0.00043806908,
0.0042522345,
0.02275324,
0.02117224,
-0.01034897,
-0.007990643,
-0.038418327,
0.017878488,
-0.0015933528,
-0.009795619,
-0.049406286,
-0.008794319,
0.01364931,
0.016903536,
0.009868083,
-0.025137918,
-0.008458356,
0.03183082,
0.02217354,
-0.035229977,
0.004074372,
0.0052041286,
0.020869216,
0.020632066,
-0.0066698487,
-0.0132540595,
0.0137810595,
0.018194688,
0.012858809,
-0.016943062,
0.008807494,
0.019670289,
-0.01462426,
0.010763983,
-0.02017094,
0.009499182,
0.023741366,
0.0021623485,
0.0010136523,
0.0048516975,
-0.015362062,
0.011482021,
-0.034940124,
-0.013155247,
-0.008926069,
-0.028853271,
-0.0041270717,
0.016060337,
-0.02887962,
-0.00008383629,
-0.0011659884,
0.023780892,
0.012680947,
-0.013082785,
-0.0062284856,
0.011844333,
-0.00091072253,
0.008471531,
0.018550413,
-0.028616121,
0.021527966,
0.022252591,
0.005095435,
0.019116938,
-0.030170772,
-0.0050361473,
0.018352788,
-0.0013026791,
0.018589938,
0.0056981915,
-0.009347669,
0.030302523,
-0.023635967,
0.003712059,
0.009558469,
-0.011205345,
-0.0053556412,
0.024465993,
-0.005138254,
0.023346117,
-0.018853439,
0.021910042,
-0.0088997185,
0.022674192,
-0.02764117,
-0.030750472,
-0.031857174,
0.029828222,
0.017061638,
0.00039010379,
-0.0023303297,
0.008781143,
0.029380271,
-0.011949734,
-0.005042735,
-0.018352788,
-0.023965342,
-0.0047825286,
-0.010513658,
-0.0073516555,
-0.6210173,
-0.035783324,
0.0016378184,
0.0023715016,
0.017351488,
0.023425167,
0.010171107,
-0.008471531,
-0.01386011,
0.004499266,
-0.01092867,
0.0046968907,
0.006225192,
-0.011001133,
-0.0044795033,
-0.018471364,
-0.0029050896,
0.0005101199,
0.01443981,
-0.0009214272,
-0.04084253,
0.004360928,
-0.013794235,
0.018392313,
-0.0027222864,
-0.005546679,
0.009446482,
-0.0046738344,
-0.009288382,
0.01412361,
-0.028932322,
0.018352788,
-0.0048747533,
0.00019741929,
0.053885788,
0.0041336594,
0.023570092,
0.03862913,
-0.0039854404,
0.02843167,
-0.010889146,
0.02563857,
0.021672891,
-0.010994545,
-0.017997064,
0.006956405,
0.00781278,
-0.00034131508,
0.009782445,
-0.0023171548,
0.01443981,
0.032911174,
-0.02082969,
0.017891662,
0.026573995,
0.020157764,
0.030618722,
0.0023352704,
0.012252759,
0.0062317797,
0.0052469475,
0.047377333,
-0.0072660176,
0.0030911865,
-0.012733647,
0.02727227,
-0.02700877,
0.0014986573,
0.012424034,
-0.016982587,
0.026191918,
0.017825788,
-0.01467696,
0.0067917174,
0.013405573,
0.011192171,
-0.0037021777,
0.017311962,
-0.005520329,
0.017601812,
-0.000345844,
-0.017575463,
-0.008781143,
0.02030269,
0.02779927,
-0.02035539,
-0.010684933,
0.0049274536,
-0.016442413,
0.0091632195,
0.014940461,
0.019195989,
-0.00060810905,
-0.044979483,
-0.007088155,
-0.0066731423,
-0.00074727007,
-0.007437293,
-0.015296186,
-0.023741366,
-0.025954768,
-0.0043971594,
-0.0005965809,
0.013925985,
0.02151479,
-0.0023929111,
-0.046744935,
-0.013128897,
0.049775187,
-0.018484538,
0.026086519,
0.015309361,
-0.0022002265,
-0.0013142072,
-0.0066171484,
-0.011745521,
0.029986322,
-0.005932048,
-0.01459791,
-0.012562372,
0.01399186,
0.004828641,
0.006488692,
-0.0064722234,
0.025230143,
0.008530819,
-0.0013290291,
0.017838962,
-0.0076151555,
-0.0020536545,
0.004907691,
-0.009123694,
-0.0012648009,
-0.029880922,
0.029143121,
-0.004074372,
0.0052074227,
-0.01063882,
0.030276172,
-0.015744137,
-0.040131077,
-0.0059386357,
-0.0071474425,
0.0050328537,
-0.014729661,
0.0015595917,
-0.020065539,
-0.012325222,
0.021765117,
0.0051909536,
-0.0060967356,
0.0021376454,
-0.00043642218,
0.0136624845,
-0.0013314994,
-0.0003845456,
0.0049900347,
-0.032937523,
0.011653296,
-0.01364931,
-0.012990559,
0.026890194,
-0.009518945,
0.017970713,
-0.019867914,
-0.016916713,
-0.009064406,
0.032990225,
-0.015796836,
-0.0080828685,
-0.0047825286,
-0.005230479,
-0.0015151261,
-0.012239584,
-0.004719947,
0.0056454916,
0.004828641,
0.0023352704,
-0.04205463,
-0.020131415,
0.014255361,
-0.01375471,
-0.002061889,
-0.011521546,
0.022502916,
0.022871817,
0.049458984,
0.00073450676,
-0.0049834475,
0.023609618,
-0.011363446,
0.023543742,
-0.006435992,
-0.008919481,
-0.00081767404,
-0.038497377,
0.0021738766,
0.0040480215,
0.004281878,
0.029406622,
-0.009703395,
-0.031198423,
0.011422733,
0.0020816515,
0.025796669,
-0.017694037,
-0.0076415055,
-0.016982587,
0.0059649856,
0.0040216716,
-0.00744388,
0.010704695,
-0.011027483,
-0.019301388,
0.0020964735,
-0.00733848,
-0.019828388,
-0.01436076,
-0.0066698487,
-0.004163303,
-0.018128812,
0.014294885,
-0.00025444236,
-0.019709814,
-0.0011824571,
0.02698242,
0.01267436,
0.012957622,
0.016547812,
0.002460433,
0.002131058,
0.009150044,
-0.005230479,
0.00037878152,
0.011666471,
0.009703395,
-0.0033266898,
-0.00718038,
0.049037386,
-0.0020816515,
0.0016534637,
0.006129673,
0.013978685,
-0.004667247,
-0.0065150424,
-0.018603113,
0.034729324,
-0.0069761677,
-0.0029363802,
0.014571561,
-0.017048463,
-0.004973566,
-0.02748307,
-0.031224772,
0.010757395,
-0.024545042,
0.02038174,
0.012536022,
0.021738766,
0.0041567157,
0.017970713,
-0.0020849453,
0.0049900347,
-0.03154097,
0.008181681,
0.0039656777,
0.011554483,
0.02816817,
-0.011916796,
0.019340914,
-0.015493811,
-0.014690136,
0.0029149707,
-0.037337977,
0.008445181,
0.00987467,
0.014611086,
0.018036587,
0.018339613,
-0.0019778984,
-0.003418915,
-0.03876088,
0.012160534,
0.01993379,
-0.017680863,
-0.009156631,
-0.013181597,
-0.021975916,
-0.0021475265,
0.0042357654,
0.01380741,
0.02682432,
-0.024637267,
-0.00995372,
-0.02198909,
-0.009749507,
0.011903621,
-0.012246171,
0.026560819,
0.01407091,
0.009215919,
-0.014215835,
-0.0026613518,
-0.001655934,
0.02774657,
0.0033480993,
-0.0070420424,
-0.014057735,
-0.014242185,
-0.031330172,
-0.018379139,
-0.01349121,
-0.010889146,
-0.0042917593,
0.003962384,
0.003153768,
0.0091039315,
-0.014637436,
0.008432006,
0.017773088,
-0.008932657,
-0.035625227,
-0.011976084,
-0.029432971,
0.038971677,
0.044294383,
-0.018392313,
0.002037186,
0.004575022,
0.025296018,
0.01388646,
-0.029512022,
0.022884991,
-0.017008938,
0.0014723074,
0.014321235,
0.032278772,
0.00084978814,
0.014940461,
0.02790467,
0.015691437,
-0.02030269,
-0.019736165,
0.011119708,
0.004067784,
-0.016455587,
0.009545295,
0.058444344,
0.021343516,
0.012160534,
0.004443272,
0.015770486,
-0.017891662,
-0.018919313,
-0.020684766,
0.017957538,
0.0038141652,
0.015691437,
0.008412244,
-0.02159384,
0.004894516,
0.02185734,
0.011771871,
-0.00031496506,
0.01048072,
0.0043675154,
0.0009123694,
-0.012358159,
-0.0036955902,
-0.0044630347,
-0.010790333,
0.011626946,
-0.030539673,
-0.005988042,
0.034439474,
-0.028747872,
-0.008240968,
-0.026323669,
0.006277892,
0.0051678973,
-0.010342383,
-0.013280409,
-0.0021607017,
0.0067653675,
-0.01291151,
-0.013076197,
0.01372836,
-0.009051232,
-0.0046639536,
-0.030065373,
-0.0007876185,
-0.002659705,
-0.032436874,
0.010210632,
0.018431839,
-0.002952849,
-0.033543576,
0.009947132,
0.02864247,
0.019578064,
0.029801872,
-0.025216969,
0.0008390834,
0.03190987,
0.005948517,
-0.024953468,
-0.008820669,
-0.019762514,
0.008267319,
0.018010238,
0.013142072,
-0.01008547,
-0.04202828,
0.003191646,
0.022068141,
-0.001251626,
0.0021985797,
-0.01066517,
-0.008188268,
0.0021491735,
0.023095792,
0.032436874,
-0.009782445,
0.007832543,
0.010810095,
-0.020105064,
-0.04231813,
-0.03683733,
-0.0068575926,
-0.04416263,
-0.017983887,
0.0038668653,
-0.0022644547,
-0.016784962,
0.005968279,
-0.023741366,
0.01380741,
-0.021369865,
0.009868083,
0.0098944325,
0.019288214,
0.032700375,
-0.0025641862,
-0.0019400201,
0.01462426,
-0.03844468,
0.045769982,
0.015770486,
-0.000033786695,
-0.011007721,
-0.008524232,
-0.00047841753,
-0.049643435,
-0.012555784,
0.020078715,
0.015586036,
-0.02761482,
-0.034281373,
-0.013379222,
0.009209332,
-0.00014338116,
0.020065539,
0.014663786,
-0.016929887,
-0.00092883816,
0.017061638,
-0.000951071,
-0.0042456468,
0.046850335,
-0.033596274,
-0.004268703,
0.015059036,
0.02869517,
0.009347669,
-0.0135175595,
-0.009084169,
-0.018642638,
-0.009986658,
-0.0045651407,
-0.02785197,
0.035203625,
-0.013557085,
0.052436538,
0.03135652,
0.052568287,
0.008458356,
0.023385642,
0.01998649,
0.0015085386,
-0.0038075778,
-0.012918097,
0.030618722,
-0.019538539,
0.020473965,
0.0013273822,
0.016402887,
0.017746737,
-0.02895867,
0.036020476,
0.033965174,
-0.002221636,
-0.04110603,
-0.006435992,
-0.05638904,
-0.02745672,
-0.0058826418,
-0.0036099525,
0.007325305,
-0.023411991,
0.013155247,
0.035440776,
0.0095716445,
-0.020948265,
-0.0054610413,
0.034887426,
0.012463559,
0.040025678,
-0.031699073,
-0.008188268,
-0.0021228234,
-0.017535938,
0.015138086,
-0.011290983,
0.0039953217,
-0.009294969,
0.0019614296,
0.011732346,
-0.02241069,
0.015810011,
-0.0072594304,
-0.022858642,
-0.03891898,
-0.021132715,
-0.032779425,
-0.016495112,
-0.038128477,
-0.021962741,
-0.026705744,
0.0013932573,
0.017694037,
-0.04007838,
0.02558587,
0.009064406,
-0.01357026,
0.015401586,
-0.013135484,
0.01465061,
-0.02853707,
0.022542441,
0.024531867,
-0.004993329,
-0.017799437,
0.008840431,
0.0021705828,
-0.0038108714,
0.032041624,
0.033780724,
-0.018326439,
-0.01341216,
0.011198758,
-0.012601896,
-0.02837897,
-0.04295053,
-0.0007583865,
-0.0074570556,
-0.004080959,
0.00006273569,
-0.002781574,
-0.05098729,
-0.003259168,
-0.0073516555,
0.005892523,
0.017588638,
-0.016929887,
-0.001123993,
0.01909059,
-0.010816683,
-0.002022364,
0.0075624553,
-0.0079050055,
-0.012615072,
-0.018668989,
0.004255528,
0.0038701592,
-0.012022196,
0.030223472,
-0.02053984,
0.0011355211,
0.008504469,
-0.004298347,
0.02758847,
0.0014895995,
0.00987467,
0.045717284,
-0.025783494,
0.0030434271,
-0.0028408614,
-0.000247649,
0.0013067962,
0.012918097,
-0.015770486,
0.0014056088,
-0.045980785,
-0.029274872,
0.024610918,
0.0035341964,
-0.0065150424,
0.011007721,
-0.035519827,
-0.0022002265,
-0.024755843,
-0.018945664,
0.013036672,
-0.02743037,
-0.0008522584,
0.0040776655,
0.011119708,
0.01880074,
-0.0062581296,
0.0134319225,
0.009387194,
0.013300172,
-0.0066171484,
0.025599044,
0.006607267,
0.017430538,
-0.022199892,
0.011284396,
-0.010632233,
-0.032252423,
-0.0008563756,
-0.0076019806,
-0.04084253,
-0.014005035,
-0.0077403183,
0.019485839,
0.0042719967,
0.01021722,
0.02053984,
0.0033859774,
0.011903621,
0.008893131,
-0.013899635,
0.011528133,
-0.025533168,
-0.00079502945,
0.0014261948,
-0.0073582428,
0.0071606175,
-0.021910042,
-0.02948567,
-0.0022430455,
0.0065380987,
0.0048582847,
-0.0075492803,
-0.007727143,
0.010283095,
-0.01988109,
-0.0070222802,
-0.022015441,
-0.032963872,
0.018550413,
-0.0053095287,
-0.0034090336,
-0.023451516,
0.003830634,
0.0039096843,
0.02090874,
-0.008543993,
-0.0010013008,
-0.011159233,
-0.013846935,
-0.04052633,
-0.00937402,
-0.011956321,
0.022871817,
0.034255024,
0.022423865,
-0.0079642935,
-0.0069366423,
-0.030302523,
-0.02645542,
0.012924684,
-0.0024357298,
0.014532035,
0.022568792,
-0.011521546,
-0.010131583,
0.01586271,
-0.0017061637,
0.013319935,
-0.0073780054,
0.0013660837,
0.0010276508,
0.023201192,
0.0024900767,
-0.0004775941,
-0.02056619,
0.016969413,
0.00484511,
-0.01359661,
-0.0007439763,
0.0070025176,
0.02151479,
-0.016218437,
0.023675492,
0.016481936,
0.004644191,
0.02022364,
-0.023794068,
-0.02030269,
-0.013557085,
-0.005375404,
-0.0155069865,
0.017588638,
-0.0043148156,
0.016416062,
-0.023135317,
-0.015730962,
-0.023583267,
0.008181681,
-0.030276172,
0.028800571,
0.012272521,
0.032120675,
0.021435741,
0.0039953217,
-0.012041959,
-0.009275206,
-0.018853439,
-0.011363446,
-0.012140771,
0.0024324362,
-0.009709982,
0.00696958,
-0.020974616,
0.0064030546,
-0.038102128,
0.0053951666,
-0.01880074,
-0.018221037,
-0.02629732,
0.034992825,
-0.031488273,
-0.018827088,
-0.023188017,
-0.010072295,
-0.020684766,
-0.01393916,
0.000015941247,
-0.0068905298,
-0.034334075,
-0.00024085565,
0.00678513,
0.0038899216,
-0.0062713046,
-0.008735031,
-0.02217354,
0.0032674023,
0.024834894,
0.18202592,
-0.0007559162,
-0.008346369,
0.01993379,
-0.009677044,
-0.018431839,
0.034044225,
0.0047298283,
-0.0066467924,
0.018919313,
0.02212084,
-0.0006892177,
0.00046771285,
0.0010531773,
0.033332773,
-0.007186968,
0.005839823,
0.016363362,
-0.016402887,
-0.04437343,
0.01032262,
-0.030566022,
-0.005918873,
0.0075229304,
0.01359661,
0.0029923741,
-0.016165737,
-0.01008547,
-0.0074307052,
0.000016365831,
-0.012957622,
-0.011119708,
-0.014571561,
-0.017022112,
-0.0009625991,
-0.009729745,
-0.011850921,
-0.024689969,
-0.014215835,
-0.0075031677,
0.0002669998,
0.005918873,
-0.0017539231,
0.028932322,
-0.014532035,
0.009993245,
0.0085505815,
0.0064195236,
0.00052576524,
-0.009024882,
-0.05580934,
-0.004624428,
0.0069629927,
0.017773088,
-0.0082277935,
0.00518766,
0.019828388,
0.005388579,
-0.0008189092,
0.016152563,
-0.018550413,
0.009097344,
-0.020012839,
0.02858977,
-0.02829992,
0.025519993,
-0.018603113,
-0.0048912223,
0.0063602356,
-0.02072429,
-0.015770486,
-0.002793102,
-0.009446482,
0.030065373,
0.0054050474,
-0.013115722,
0.029749172,
0.014136786,
-0.0020454202,
0.0028787395,
0.0029824928,
-0.0000118755215,
-0.027035119,
0.020052364,
-0.011679646,
-0.03978853,
0.020342214,
0.011831159,
-0.00042489407,
-0.04284513,
-0.006692905,
-0.00019031714,
0.005800298,
-0.017614989,
-0.01927504,
0.01293786,
0.014611086,
0.018603113,
-0.0049043973,
0.0028556832,
-0.04194923,
0.05522964,
0.010678345,
0.0030351928,
-0.0044597406,
0.016086686,
-0.006129673,
0.00027852794,
-0.033648975,
-0.013530735,
-0.0034222088,
-0.021488441,
0.032647673,
-0.012219821,
-0.01034897,
0.024268368,
-0.001981192,
-0.031804472,
0.046112534,
-0.014294885,
0.006238367,
-0.038049426,
-0.0040611965,
0.02122494,
-0.02869517,
-0.023556918,
-0.014321235,
-0.009742919,
-0.024597744,
-0.049090084,
-0.015177611,
-0.009143457,
0.0016592278,
-0.0020404796,
0.0047265347,
-0.00091731,
0.011923384,
-0.00984832,
-0.01436076,
0.009973482,
-0.013794235,
-0.0010482367,
0.023411991,
-0.013023497,
-0.014400286,
-0.030091722,
0.024769017,
0.018379139,
-0.02719322,
-0.017008938,
-0.025730794,
-0.02117224,
-0.006956405,
0.017311962,
0.022858642,
-0.014663786,
-0.013214534,
-0.031119373,
-0.007219905,
0.030460622,
-0.01980204,
0.039656777,
0.008524232,
0.010810095,
-0.015085386,
-0.0047430033,
-0.16410792,
-0.0047034784,
0.025019344,
-0.04129048,
0.03847103,
-0.0000873359,
0.009505769,
-0.011692821,
-0.008016993,
0.008333193,
0.02162019,
0.013609785,
-0.032120675,
-0.016323837,
-0.0033760963,
0.017140687,
0.00969022,
0.046059832,
0.017219737,
-0.003712059,
0.037469726,
-0.016943062,
0.030039022,
-0.016113037,
0.004001909,
-0.0025790082,
-0.010678345,
-0.0065413923,
0.005642198,
-0.026613519,
-0.012028784,
-0.012588722,
0.0013743181,
-0.010329207,
0.0037285278,
-0.0070552174,
-0.0076546804,
-0.003140593,
0.005480804,
0.017549112,
0.013543909,
0.012134184,
0.017825788,
0.0058299415,
-0.004604666,
0.044188984,
0.005549973,
-0.006452461,
0.04197558,
-0.019064238,
0.02727227,
-0.011719171,
0.006146142,
0.011482021,
0.017944364,
0.012101246,
0.021910042,
-0.006001217,
0.0009313085,
-0.0041600093,
-0.011936558,
-0.0070222802,
0.030302523,
-0.003646184,
0.013128897,
-0.02275324,
-0.001795095,
0.015059036,
-0.031066673,
0.0017259263,
-0.01343851,
-0.0003880452,
-0.006676436,
-0.009486007,
0.02801007,
0.00992737,
0.009782445,
-0.0074175303,
-0.014808711,
0.00521401,
-0.022068141,
0.032278772,
-0.028747872,
-0.015085386,
-0.011864096,
0.02882692,
0.014914111,
-0.0030351928,
-0.011521546,
0.008023581,
0.02017094,
-0.016995762,
0.007845718,
-0.009973482,
0.019472664,
0.014571561,
-0.018906139,
-0.013155247,
0.016468761,
-0.0038635714,
-0.009703395,
-0.007219905,
-0.006146142,
0.010922083,
0.023596441,
-0.0086955065,
-0.014189485,
0.008735031,
0.04005203,
-0.008306843,
0.006406348,
0.0047825286,
0.012516259,
0.016864013,
-0.0005010621,
0.0057113664,
0.004614547,
-0.009617757,
-0.0050493223,
-0.0081685055,
0.060973942,
-0.0085505815,
0.006014392,
0.034386776,
0.018247388,
-0.0014788948,
-0.12352889,
-0.009077582,
-0.032594975,
0.012759997,
0.012759997,
0.011146058,
0.015559686,
0.034650274,
-0.021422565,
0.036125876,
-0.016534638,
-0.020632066,
-0.005675135,
-0.0031109492,
-0.002554305,
-0.02798372,
0.0025773612,
-0.008708681,
-0.021238115,
0.032647673,
-0.0029627304,
0.00029561427,
-0.017812613,
-0.0025246611,
-0.0033958587,
0.031646375,
-0.036626525,
0.029907271,
0.017008938,
0.036442075,
0.004262116,
0.00007374917,
0.015045861,
-0.0067653675,
-0.028853271,
0.0016756966,
-0.0038372215,
-0.032594975,
0.035177276,
0.0006525747,
0.0039953217,
0.028563421,
0.011594009,
0.018958839,
0.023477867,
0.00521401,
0.02009189,
0.018062938,
0.004219297,
-0.012035371,
-0.032990225,
-0.0044202157,
-0.016007636,
-0.0028375676,
0.02787832,
-0.018365962,
0.025137918,
0.011844333,
-0.0028952083,
-0.011409558,
-0.00566196,
0.002340211,
-0.015059036,
0.019828388,
0.016732262,
-0.04474233,
-0.02719322,
-0.021435741,
0.023253892,
-0.021541141,
-0.008418831,
0.016244786,
-0.02895867,
-0.004199534,
-0.01386011,
0.017074812,
-0.019169638,
0.002180464,
-0.0006262247,
-0.012200058,
0.005444573,
-0.0147164855,
0.022213066,
-0.004614547,
0.024505518,
0.000704863,
0.010790333,
0.004400453,
-0.0036922963,
0.016284311,
0.000545116,
0.036810976,
-0.013846935,
-0.02077699,
-0.01375471,
0.009031469,
0.010513658,
0.0014311355,
0.034861077,
0.020526664,
-0.012246171,
-0.012746822,
-0.045427434,
0.02735132,
0.0060901484,
-0.0066303234,
0.005549973,
-0.014057735,
0.011356859,
-0.02737767,
0.0011915149,
0.008069693,
-0.00667973,
-0.003656065,
-0.019578064,
-0.012088072,
-0.01320136,
-0.026310494,
0.02869517,
0.0012219822,
0.023043092,
0.018405488,
-0.018023413,
0.018418664,
0.008965594,
-0.0054709227,
-0.007648093,
-0.0015003042,
-0.0013150306,
0.023807243,
-0.020790165,
-0.0029314396,
0.008484706,
-0.038971677,
-0.009736332,
-0.0037878153,
-0.023188017,
-0.028326271,
-0.0045816097,
0.02592842,
0.018813914,
0.023820417,
-0.018655814,
-0.02727227,
0.015190786,
-0.006557861,
0.0007736201,
0.011620359,
-0.02840532,
0.0022166953,
0.010474132,
-0.008333193,
0.049538035,
-0.007542693,
0.0017588638,
-0.006100029,
0.0010647054,
-0.02611287,
0.005401754,
0.010019595,
0.007931355,
-0.021554315,
-0.015849536,
0.0063536484,
0.025032518,
-0.007858893,
-0.008412244,
-0.020553015,
-0.02246339,
0.019578064,
-0.008023581,
-0.025269669,
-0.019143289,
0.033332773,
0.032647673,
-0.015296186,
0.007845718,
-0.006824655,
-0.017101163,
-0.017364662,
-0.000741506,
-0.0045025595,
-0.009117107,
0.009808795,
-0.011495196,
0.009597994,
0.044979483,
0.0061362605,
-0.025243318,
0.012628247,
0.011745521,
-0.006274598,
0.005638904,
0.00248843,
0.022094492,
0.010803508,
0.017746737,
0.020421265,
-0.008945831,
0.01414996,
0.010309445,
0.023767717,
0.010645407,
0.00032319946,
-0.008306843,
-0.015414761,
0.009123694,
0.04044728,
-0.017259263,
-0.028273571,
-0.013530735,
0.012483321,
0.019591238,
0.011383208,
-0.005958398,
0.019960139,
-0.01903789,
0.023227543,
-0.023188017,
-0.0052963537,
-0.00047347692,
0.035941426,
0.018589938,
0.016864013,
0.008425418,
0.015045861,
0.02093509,
0.017338313,
0.027087819,
-0.04205463,
0.011949734,
-0.007687618,
0.055124238,
-0.02758847,
-0.038708176,
-0.0000980406,
0.00058546447,
-0.024979819,
0.0034024462,
0.030987622,
-0.019011538,
0.07051265,
0.009709982,
-0.0027074644,
-0.002075064,
-0.027035119,
0.017680863,
0.010935258,
0.02164654,
-0.037232578,
-0.023029916,
0.035098225,
-0.04379373,
0.04073713,
-0.028905971,
-0.019340914,
0.02204179,
-0.018576764,
0.032120675,
-0.0057014856,
-0.021580666,
0.02188369,
-0.008036756,
0.015467461,
0.01343851,
-0.029696472,
-0.017087987,
0.003926153,
-0.0062482483,
0.015427936,
-0.02737767,
0.010493895,
-0.0044531533,
-0.012522846,
-0.007621743,
-0.00057146605,
-0.013873285,
0.006277892,
-0.033464525,
-0.006725842,
0.016640037,
-0.030539673,
0.0025921832,
-0.009578232,
-0.032963872,
-0.011330509,
0.0028556832,
-0.017259263,
-0.005843117,
0.0065644486
] |
To identify predictive molecular markers for gemcitabine resistance, we investigated changes in the expression of four genes associated with gemcitabine transport and metabolism during the development of acquired gemcitabine resistance of pancreatic cancer cell lines. The expression levels of human equilibrative nucleoside transporter-1 (hENT1), deoxycytidine kinase (dCK), RRM1, and RRM2 mRNA were analysed by real-time light cycler-PCR in various subclones during the development of acquired resistance to gemcitabine. Real-time light cycler-PCR demonstrated that the expression levels of either RRM | [
-0.01941993,
-0.00980952,
0.015915582,
-0.02965422,
-0.0051602856,
0.020481855,
0.00036669555,
-0.0026846759,
-0.03230903,
0.002800824,
0.012889099,
0.016712025,
0.008269731,
0.013858105,
-0.0069556003,
0.0052233376,
0.02236677,
-0.0028157572,
-0.016685477,
-0.008422383,
-0.043087557,
-0.0074865622,
0.0017372408,
-0.031273656,
0.0018367962,
0.020840254,
0.0074666515,
-0.03881331,
-0.017627934,
-0.017760675,
-0.0025701872,
0.023601254,
-0.018464198,
-0.002049181,
-0.019645588,
-0.009205552,
-0.005817351,
-0.0075662066,
0.011077192,
-0.008422383,
0.015225331,
-0.0019877886,
0.0030264826,
0.0027676388,
-0.0036271333,
-0.009915713,
0.009258647,
-0.028140979,
-0.011163473,
0.0075529325,
-0.006564016,
0.008754234,
-0.015928855,
-0.008940071,
-0.008880338,
-0.0054191295,
0.0031476084,
0.037432812,
-0.0188226,
-0.0037266887,
-0.0070352447,
0.009172366,
-0.034751453,
0.014654548,
0.020096907,
-0.003268734,
0.01166125,
0.0017554926,
0.01630053,
0.013751913,
0.012159027,
0.023282679,
0.008336102,
0.00856176,
0.044043288,
-0.022486236,
-0.032494865,
-0.00057161367,
-0.007008697,
0.017707579,
0.013566076,
-0.013698816,
-0.024331328,
0.025738377,
0.029840058,
0.009072811,
-0.0127099,
0.0061160172,
0.007745406,
0.0029169717,
0.004483309,
0.021742888,
0.014694369,
0.022326946,
-0.008269731,
0.012371412,
0.0077321324,
0.030955076,
0.0020458624,
-0.041866343,
-0.012875825,
0.027902046,
-0.012563885,
-0.016194336,
-0.011070555,
0.015145687,
-0.0011963234,
0.00005439248,
-0.002439106,
0.004324021,
0.006205617,
0.028884325,
-0.023853462,
-0.024689727,
0.0021703066,
-0.0052565224,
0.013725365,
-0.019526122,
-0.004635961,
0.0011681161,
-0.013751913,
0.004689057,
0.035388608,
-0.020707512,
0.033689532,
0.012902373,
-0.018331459,
-0.000934161,
0.004071814,
0.0028240534,
0.0023926469,
0.013439972,
0.02299065,
-0.01023429,
-0.035255868,
-0.0010303978,
-0.029335644,
-0.012165664,
-0.01663238,
-0.029601125,
-0.001054457,
0.032229386,
-0.012962107,
0.01346652,
-0.011044007,
-0.006570653,
0.021119008,
0.0075794808,
0.008521938,
0.008973256,
0.003315193,
-0.013055025,
-0.008203361,
-0.010260838,
0.010758615,
0.012371412,
0.009955535,
-0.009179004,
-0.03384882,
-0.012543974,
0.0015431079,
-0.011979827,
0.0069821486,
0.021902177,
0.0146147255,
0.027264891,
0.03676911,
0.00035839927,
-0.00074873917,
0.004765383,
-0.004158095,
0.0059434543,
-0.024092395,
0.023587981,
-0.0030978306,
0.009404662,
0.0065938826,
0.012616982,
-0.03496384,
-0.017827045,
-0.024649905,
0.029972797,
0.014428888,
-0.013293958,
-0.012026287,
-0.009152455,
0.005714477,
0.010400215,
0.0038162884,
-0.03143294,
-0.00020605883,
0.014375793,
0.0032986007,
-0.031645328,
-0.6367295,
-0.039370824,
-0.007088341,
-0.009670143,
0.005266478,
0.044892825,
0.028167527,
0.0077653173,
-0.025141045,
0.020601321,
-0.02007036,
0.026813574,
-0.001150694,
-0.017282808,
-0.015464265,
-0.035388608,
-0.011183385,
-0.01955267,
0.023282679,
0.0041149543,
-0.013884653,
0.007413555,
-0.016021775,
0.022061465,
0.009451121,
0.0107918,
0.016048323,
0.009384751,
-0.0006508431,
0.04635297,
-0.030052442,
0.02145086,
-0.0056381514,
-0.0008735982,
0.047574185,
-0.011740894,
-0.007818414,
-0.00078565767,
0.0121855745,
0.050627213,
0.0081834495,
-0.0033566745,
0.014774014,
0.018650036,
-0.026468448,
0.026879944,
0.01817217,
0.0041215913,
-0.0072476296,
-0.0034313411,
-0.0066967565,
0.018504022,
-0.035468254,
-0.0029982752,
0.00073007256,
0.0103006605,
0.021397764,
-0.022804812,
0.027822401,
-0.0058405804,
0.005724433,
0.017269535,
-0.0034678448,
-0.028884325,
-0.010745341,
0.012006375,
-0.0023926469,
-0.00610938,
0.0040917248,
0.0052432483,
0.015928855,
0.021981822,
0.012059472,
0.041707054,
0.03953011,
0.040857516,
0.0011540124,
0.0074666515,
0.0064180014,
0.016844766,
-0.00682286,
0.00626535,
-0.029468384,
0.0072609037,
0.03092853,
0.012816092,
-0.009663506,
0.008800693,
-0.0019380108,
-0.00043223615,
0.019433204,
-0.0028257128,
-0.022393316,
-0.030052442,
-0.006524194,
0.013605898,
-0.0030845567,
0.029388739,
0.006623749,
-0.033689532,
-0.030132087,
-0.021756163,
0.016526189,
-0.0075197476,
0.027530372,
-0.007148074,
-0.021318119,
0.0012759677,
0.029282548,
-0.018809324,
0.0013099825,
0.0060695577,
-0.007679036,
-0.032574512,
0.0074002813,
-0.028645393,
0.01413686,
0.016539462,
0.007592755,
-0.05622886,
-0.00056290254,
-0.004499902,
0.013632446,
-0.008508664,
0.008827241,
0.0069157784,
-0.0011365903,
0.0049711303,
0.03175152,
0.0020392255,
-0.007652488,
-0.017216438,
0.01290901,
-0.020375662,
0.016645655,
-0.029893152,
0.02519414,
0.008780782,
-0.004715605,
-0.044361863,
-0.016884588,
-0.019260641,
-0.007267541,
-0.015995227,
-0.0039656213,
-0.0090529,
-0.021636697,
-0.0024357876,
0.009172366,
0.007931243,
0.008687863,
0.0020508403,
0.010307297,
0.02249951,
0.030556856,
-0.024384424,
-0.021543778,
-0.01872968,
0.00007373318,
-0.021756163,
0.012105931,
-0.004655872,
-0.02243314,
-0.0077122212,
0.003547489,
-0.02263225,
0.016194336,
0.015968679,
-0.014123586,
-0.02125175,
-0.0011399088,
-0.010864807,
-0.012915648,
0.010406853,
0.0024026025,
0.019990714,
-0.010240927,
-0.0047952496,
0.007665762,
-0.004324021,
0.03387537,
-0.013055025,
-0.016327078,
-0.0033533562,
0.031167462,
0.030317923,
0.009982083,
0.022353495,
-0.0030082308,
0.03092853,
-0.02896397,
0.016181063,
-0.005717796,
0.03509658,
0.027477277,
0.0007404429,
0.020296017,
0.010605963,
0.0049313083,
0.034565616,
0.010605963,
-0.0041813245,
-0.005034182,
-0.015504086,
0.01734918,
-0.020428758,
-0.0040452657,
0.002374395,
0.016380174,
0.00007181467,
0.0010884719,
0.022618975,
-0.007599392,
-0.0054854997,
-0.030025894,
0.00048201383,
-0.02742418,
-0.012298404,
-0.0063980906,
-0.015610279,
-0.005920225,
0.02354816,
0.025101222,
0.009962172,
-0.021795984,
0.010154646,
-0.004602776,
0.012517426,
0.0016874631,
-0.0045098574,
-0.013453246,
0.0154244425,
0.0131346695,
-0.0052697966,
0.023136664,
-0.0123249525,
0.025525993,
-0.0027095648,
0.039609756,
0.004483309,
0.011150199,
0.0028257128,
-0.00070850225,
-0.0055087293,
0.0033218302,
-0.015636828,
0.01649964,
0.04218492,
-0.009105996,
0.017601386,
-0.008442294,
0.025300333,
-0.021756163,
-0.0040950435,
0.0021288253,
-0.0042443764,
0.018477473,
0.0341143,
0.047972403,
0.021941999,
0.022459688,
0.0020641142,
-0.00020118477,
-0.0026415354,
0.00017785149,
0.026840122,
0.014402341,
-0.025725102,
0.009165729,
0.009079448,
-0.010758615,
-0.007406918,
0.014110312,
-0.006029736,
-0.011521872,
0.012291768,
0.0042908355,
-0.0028223942,
0.027171973,
0.010838259,
-0.007838325,
-0.036662918,
0.054635976,
0.019380108,
-0.022711894,
-0.018888969,
-0.034565616,
0.00898653,
-0.008349376,
0.015490812,
0.014309422,
0.019751782,
0.0069887857,
0.0063980906,
-0.020548224,
-0.02372072,
0.028087882,
-0.02965422,
0.0069423267,
-0.012371412,
0.0009955534,
0.0009391388,
-0.020375662,
0.0021006179,
0.018968612,
0.019433204,
-0.010148008,
-0.020216374,
0.0047122864,
-0.007898058,
-0.009159092,
0.0022648843,
0.003398156,
-0.013924475,
-0.004476672,
0.0002938957,
0.0040917248,
0.011123651,
0.015052769,
-0.007420192,
-0.019539397,
-0.028592296,
-0.011010822,
-0.0042974725,
0.0254198,
0.004921353,
-0.017455371,
0.0041614138,
0.004005444,
-0.003676911,
0.006736579,
-0.015981952,
0.0010594348,
-0.03313202,
-0.0014709303,
0.0012278493,
0.0063184462,
-0.00443685,
-0.004433532,
0.012882463,
-0.0160085,
-0.028087882,
-0.0036935036,
-0.0012029605,
-0.008462205,
-0.006623749,
0.024105668,
0.018623488,
0.016313804,
-0.020150002,
0.017734127,
0.005518685,
0.02220748,
0.0005355248,
0.0020657736,
-0.0006317617,
0.0033317858,
-0.0025818022,
-0.007672399,
-0.035282414,
0.030556856,
0.0027643202,
0.0044965832,
-0.016273981,
0.017362453,
0.0123249525,
0.016884588,
0.008475479,
0.008083895,
-0.0017073742,
-0.0075728437,
0.0053793075,
0.0053129373,
-0.038415093,
0.011946642,
-0.015889034,
-0.03076924,
-0.0029352235,
0.011747532,
0.038627476,
-0.008468842,
-0.007752043,
-0.0042974725,
-0.014428888,
0.008342738,
-0.016127966,
-0.00097481284,
-0.00081801316,
-0.014866932,
0.019327013,
-0.009378114,
-0.0177474,
-0.025300333,
0.0038926143,
0.030955076,
-0.021835808,
-0.020601321,
0.020986268,
0.0074666515,
0.011754168,
0.007327274,
-0.020388937,
0.018079251,
0.027317988,
-0.0139908455,
0.012802818,
0.0023926469,
-0.03870712,
0.006530831,
-0.013300595,
-0.012132479,
-0.004493265,
-0.014322696,
0.02325613,
-0.003282008,
-0.014787288,
0.010698882,
-0.003444615,
-0.0065341494,
0.0029070163,
0.00033226598,
0.027610017,
0.011933368,
0.0071746223,
0.004008762,
-0.0376452,
-0.00079022057,
-0.030689595,
-0.003846155,
-0.013008566,
0.0016227522,
0.01228513,
-0.0019877886,
-0.0034280226,
-0.0111568365,
-0.012338227,
-0.00045588054,
-0.004320702,
0.01495985,
0.0010328868,
-0.011681161,
0.009617046,
-0.0032786895,
0.0040187174,
0.009086085,
-0.019393383,
0.036185052,
-0.001319938,
-0.0028904236,
0.024782645,
-0.015212057,
-0.030609952,
-0.011734257,
-0.005883721,
-0.0015132413,
0.051742233,
0.0055352775,
-0.025804747,
0.010858171,
-0.0065938826,
0.0027195204,
-0.00049985084,
-0.002671402,
-0.0074998364,
-0.027875498,
0.003371608,
0.018557118,
-0.010081639,
-0.0012402937,
-0.026760478,
-0.0076060286,
0.01741555,
0.006358268,
-0.015570457,
-0.005512048,
0.019579219,
-0.021756163,
-0.0016891224,
-0.01571647,
-0.032521416,
0.013141306,
0.014389067,
0.016818218,
0.04146812,
0.027025959,
-0.007831688,
0.0313533,
0.02227385,
0.012457693,
0.0069091413,
-0.00405854,
0.028326815,
-0.023787092,
-0.0039457106,
0.0150660435,
-0.011740894,
0.0025137726,
0.000010927755,
0.022008369,
-0.0029501568,
-0.008913523,
-0.010440038,
0.0130882105,
-0.041016806,
-0.03703459,
0.01879605,
-0.02145086,
-0.0014543377,
-0.034724906,
-0.013924475,
0.032574512,
-0.0035043485,
0.012159027,
-0.01761466,
0.02604368,
-0.00918564,
0.01853057,
-0.01420323,
0.005007634,
0.0019645588,
-0.0138050085,
0.0029999346,
-0.02575165,
-0.0072409925,
-0.008840515,
0.004934627,
-0.009577225,
-0.013685542,
0.012411234,
0.0028223942,
-0.024849016,
-0.021172104,
0.00079146505,
-0.0075131105,
-0.0078715095,
-0.005601648,
-0.01134931,
-0.029309096,
-0.0049445825,
0.007685673,
-0.008614857,
0.002425832,
-0.00936484,
-0.023707448,
0.020972993,
-0.01239796,
0.030105539,
-0.0047687013,
0.020229647,
0.018092526,
-0.011282939,
-0.015504086,
-0.003235549,
0.025711829,
-0.011316125,
0.031034721,
0.03772484,
0.0064976458,
-0.007931243,
0.013247498,
0.002568528,
-0.015915582,
-0.02952148,
0.02811443,
-0.0069356896,
-0.018849146,
-0.015105865,
-0.013512979,
-0.024981756,
0.014070489,
-0.016804943,
0.014070489,
0.0015406191,
-0.00198447,
-0.01525188,
0.02004381,
0.016194336,
0.007904694,
0.013539528,
-0.041972537,
-0.023242855,
-0.019327013,
-0.0060728765,
-0.000070985036,
-0.0138050085,
0.023003923,
0.004708968,
-0.026879944,
0.01961904,
-0.019194271,
0.009145819,
-0.021158831,
-0.004967812,
0.03886641,
0.0024955207,
-0.012902373,
0.023800366,
-0.008953344,
0.024158765,
0.011614791,
-0.006142565,
-0.024809193,
-0.032946184,
-0.008209998,
0.016871313,
0.0070352447,
-0.008541849,
0.0045762276,
-0.025725102,
0.009072811,
-0.015809389,
-0.014521807,
0.016088145,
-0.061060615,
-0.031008173,
-0.0015671671,
0.015397894,
0.028618844,
-0.014216504,
0.0029584533,
-0.018769503,
0.036583275,
-0.019366834,
0.023959653,
0.018358007,
-0.010287386,
0.0021105735,
0.012504152,
-0.011813901,
-0.034592167,
0.014495259,
-0.038069967,
-0.010393579,
-0.033105474,
-0.033477146,
-0.004662509,
0.0082299085,
-0.011793991,
-0.007075067,
0.0150660435,
0.014070489,
-0.009975446,
-0.015623553,
0.02040221,
-0.040273458,
0.010858171,
0.026481723,
-0.011601517,
-0.014402341,
-0.035680637,
-0.013964297,
0.0010627534,
-0.0039025696,
-0.01340015,
-0.009252011,
0.0101148235,
-0.012212123,
0.0089931665,
0.023641078,
-0.01859694,
-0.019167723,
0.019512849,
0.025167592,
0.00083045755,
-0.0075529325,
-0.007977702,
-0.01047986,
0.010652423,
-0.023933107,
-0.00867459,
-0.023415418,
-0.014561629,
-0.039477017,
-0.0003264586,
-0.022738442,
0.028220624,
0.015477538,
-0.014468711,
-0.03732662,
-0.011243118,
-0.023800366,
-0.032202836,
0.00341143,
0.026720656,
0.0025320244,
0.025525993,
-0.01166125,
0.019685412,
0.00586381,
0.013619172,
-0.01476074,
0.010984274,
0.027742758,
-0.009570587,
0.019592494,
0.011999738,
-0.02827372,
-0.0075728437,
0.018291637,
0.011893546,
-0.0148005625,
0.034884196,
-0.01277627,
0.013340417,
-0.0032571193,
0.005226656,
-0.0017040557,
0.015703198,
0.016207611,
-0.028751586,
0.004217828,
0.01357935,
0.00437048,
0.014521807,
0.016313804,
0.037273522,
0.01886242,
0.0056514256,
-0.004397028,
-0.021225201,
0.008694501,
-0.00586381,
0.0030895344,
0.01734918,
0.011448866,
-0.006189024,
0.00867459,
-0.005966684,
0.0046791015,
-0.00071679853,
-0.00083170197,
-0.009066174,
-0.0037001406,
0.001899848,
-0.00800425,
-0.019234093,
0.009086085,
-0.0064312755,
-0.014561629,
0.014880206,
-0.008701137,
-0.03092853,
0.007393644,
-0.0019960848,
0.0021537142,
-0.025499444,
0.010645785,
-0.016990779,
-0.0009150796,
-0.015145687,
0.02354816,
-0.016990779,
0.010001995,
-0.024092395,
0.0059965504,
0.015968679,
-0.019526122,
-0.036158502,
-0.015225331,
0.007440103,
0.1934825,
-0.010506408,
0.0019894477,
0.0045430423,
0.027145425,
-0.019380108,
0.025579087,
0.0094113,
-0.008170175,
0.011886909,
0.015769567,
0.015079317,
-0.023229582,
-0.012762996,
0.011316125,
0.0053096185,
-0.048901588,
-0.008050709,
-0.021888902,
0.0035707185,
0.006829497,
-0.0050540934,
0.0018069296,
0.0006205617,
0.023282679,
-0.0077852285,
-0.008382561,
0.009471033,
0.0038992513,
-0.018026156,
-0.044468056,
0.004022036,
-0.015145687,
-0.005402537,
0.011501961,
0.003520941,
0.01433597,
-0.026707383,
-0.006155839,
0.0002943105,
-0.006504283,
-0.0046094125,
-0.028034788,
-0.014641274,
-0.0035640816,
-0.0003714659,
-0.004012081,
-0.01718989,
0.014389067,
-0.021756163,
-0.03745936,
0.0023860098,
0.025300333,
0.014986399,
-0.016181063,
0.00474879,
0.010897992,
-0.007957791,
-0.0033035784,
0.028804682,
-0.004967812,
-0.005790803,
-0.03408775,
0.040193815,
-0.016804943,
0.03623815,
-0.02936219,
0.010313935,
0.021331392,
-0.021437585,
-0.009424573,
0.000813865,
0.015477538,
0.008913523,
-0.00034222152,
-0.0035640816,
0.006504283,
-0.0028555794,
0.026879944,
0.025326882,
0.019632315,
-0.0047886125,
-0.021145556,
-0.013964297,
-0.021995096,
-0.020150002,
0.012105931,
0.0059633655,
-0.0094909435,
0.0035143038,
0.0215836,
-0.0035441704,
-0.015530635,
-0.007997613,
-0.007314,
0.019380108,
0.00026859203,
0.01172762,
0.004440169,
-0.013951023,
-0.03355679,
0.07226391,
-0.013001929,
0.009152455,
-0.01371209,
-0.008063983,
-0.0089467075,
0.0053295298,
0.0016310485,
-0.0048881676,
0.010552867,
-0.04189289,
0.011369221,
-0.015743019,
-0.0040319916,
0.028645393,
0.009928987,
-0.014853658,
0.019101353,
-0.014123586,
-0.0017588112,
-0.029256,
0.0035972667,
0.017627934,
-0.015689922,
0.002049181,
-0.0036404072,
-0.0151589615,
0.017946512,
-0.016220884,
-0.005362715,
-0.034857646,
0.0055352775,
0.008382561,
0.007838325,
-0.007167985,
0.02253933,
-0.017588113,
-0.0130417505,
0.023694173,
0.011800627,
0.0075330217,
-0.00068693195,
0.015371346,
0.0155173605,
-0.03594612,
0.027530372,
0.006189024,
-0.02512777,
-0.022340221,
-0.023441967,
-0.020455306,
-0.017760675,
0.006557379,
0.026216242,
-0.027583469,
-0.027742758,
-0.0073007257,
0.023402145,
0.020083632,
-0.025154319,
0.008940071,
0.010221016,
-0.0093051065,
-0.008010888,
0.006680164,
-0.16778395,
0.018092526,
0.022326946,
-0.03690185,
0.011959916,
0.025048126,
0.005565144,
-0.012424508,
0.0009781313,
0.014017394,
0.02519414,
0.00020979215,
-0.045875106,
-0.018902242,
0.0138050085,
0.0082763685,
-0.02519414,
0.021211926,
0.038786765,
0.011130288,
0.02952148,
-0.00437048,
0.021490682,
-0.012378048,
-0.004158095,
0.01741555,
-0.004762064,
0.0060728765,
-0.012172301,
-0.019180998,
-0.008283005,
0.017389001,
0.03706114,
-0.0046658274,
0.018450925,
0.010426763,
-0.0060065063,
-0.00056829513,
0.0028058016,
-0.0036337704,
0.024105668,
0.03860093,
0.019260641,
0.00949758,
-0.021344667,
0.01741555,
0.007705584,
-0.004380435,
0.015490812,
0.00014663674,
0.020919899,
-0.0014385749,
0.044813182,
0.0069755116,
0.03690185,
0.007858235,
-0.0039125253,
0.007373733,
-0.010001995,
-0.0075794808,
0.013698816,
-0.023561433,
0.035574444,
-0.016977506,
-0.0034910743,
-0.045052115,
-0.023601254,
-0.030716144,
-0.03315857,
0.01420323,
-0.035468254,
-0.0019960848,
0.018703131,
-0.0053527593,
0.011482051,
-0.0062487577,
-0.019141175,
0.006185706,
0.0031359936,
0.0035375336,
-0.0068693194,
0.019247368,
-0.026003858,
-0.006232165,
-0.004974449,
-0.00452645,
0.022964101,
0.025844568,
-0.0030463936,
0.0009980424,
0.017800497,
-0.026123324,
0.0072011705,
-0.019818151,
0.02909671,
0.013313869,
0.0008976574,
-0.0074666515,
0.027636565,
-0.026402079,
0.017720852,
-0.021955274,
-0.007148074,
-0.0037300072,
0.04361852,
-0.0067730825,
-0.009252011,
-0.013287321,
0.05208736,
-0.0027527055,
-0.019857975,
0.0035076668,
0.020521676,
0.026295887,
0.00050897675,
0.026919767,
-0.01837128,
-0.022526057,
-0.0014352563,
-0.0063848165,
0.049034327,
-0.005409174,
0.011196658,
0.016884588,
0.028778134,
-0.01955267,
-0.12063453,
-0.017933236,
0.004579546,
0.00867459,
-0.020933172,
0.036158502,
-0.011953279,
0.010181194,
-0.009079448,
0.041282285,
-0.02263225,
-0.006218891,
0.00013626639,
-0.002931905,
0.025433073,
0.020229647,
0.034937292,
-0.011787353,
-0.012484241,
0.03214974,
0.00039635474,
-0.0019662182,
0.0042012357,
-0.0027145427,
0.020163277,
-0.005442359,
-0.02394638,
-0.0055153663,
0.015597005,
0.022180932,
0.008163539,
0.014057215,
0.023959653,
-0.017468646,
-0.023760544,
-0.0008777463,
-0.019565945,
-0.034618713,
0.03881331,
-0.019207546,
0.009371477,
0.018052703,
-0.0018500703,
0.012869189,
0.02046858,
-0.011389132,
-0.0177474,
0.0037631923,
-0.01364572,
-0.020030536,
-0.02191545,
-0.0052001076,
-0.010805074,
0.005604966,
0.010586052,
-0.016114693,
0.019008435,
0.032574512,
-0.011336036,
-0.021490682,
-0.0037465997,
-0.02423841,
-0.016672203,
0.015769567,
0.000842902,
0.00066743564,
-0.016380174,
-0.02207474,
0.0023428693,
-0.0030596678,
-0.003067964,
-0.011588243,
-0.026176421,
-0.018052703,
-0.0326807,
-0.0033865413,
-0.016459817,
-0.007645851,
0.018026156,
-0.015557183,
0.0021288253,
-0.027822401,
0.022154383,
-0.039583206,
0.03076924,
0.013287321,
0.012198849,
0.0014103674,
0.005608285,
-0.0058969953,
-0.013897927,
0.04744144,
-0.009145819,
-0.017030602,
-0.0055352775,
0.031114366,
0.00459282,
-0.000027844388,
-0.00010588126,
0.012616982,
-0.013187765,
-0.007373733,
-0.06573308,
0.005883721,
-0.0072210813,
-0.020614594,
0.02827372,
-0.008070621,
0.00490476,
-0.006401409,
0.024424246,
-0.0039589843,
-0.025406525,
0.01103737,
-0.008488753,
-0.0018948702,
-0.025114497,
-0.005877084,
0.016658928,
0.00844893,
0.01123648,
0.03607886,
-0.020442031,
-0.008727686,
-0.0069556003,
0.009816158,
-0.017216438,
-0.014123586,
-0.005804077,
0.032733798,
-0.022127835,
-0.023349049,
-0.0016186041,
-0.029309096,
-0.0036039036,
-0.01899516,
-0.016247433,
0.0037565553,
0.01712352,
0.015636828,
0.020707512,
0.042025633,
-0.00880733,
-0.021211926,
0.00017308112,
0.0018633443,
-0.0010561163,
-0.010977637,
-0.026362257,
0.0146147255,
-0.008375923,
0.013101484,
0.019539397,
0.011057281,
0.0020641142,
-0.02682685,
-0.012099294,
-0.020481855,
-0.008017524,
-0.03676911,
-0.034645263,
-0.023654351,
0.013147944,
0.01656601,
-0.0024722912,
-0.014641274,
0.002303047,
0.0107918,
-0.027875498,
-0.020428758,
-0.007061793,
-0.030158633,
-0.020760609,
-0.018119074,
0.004287517,
0.0063217646,
-0.009603773,
-0.01190682,
0.0024341284,
0.013366965,
0.01413686,
0.004871575,
0.011130288,
0.0031409713,
-0.01944648,
0.0030563492,
0.0013680564,
0.0050574117,
0.015145687,
0.026096776,
0.014243052,
0.011561695,
0.012762996,
0.008176813,
0.0014194933,
0.0048217974,
-0.011044007,
0.015371346,
-0.019074805,
0.005289708,
0.014229778,
0.038415093,
-0.0017820408,
-0.0053527593,
0.0012485901,
-0.01482711,
-0.011342673,
0.01781377,
-0.02745073,
-0.016380174,
-0.008475479,
0.00936484,
0.0032239342,
-0.0070817037,
0.015557183,
-0.005502092,
-0.023840187,
-0.013220951,
0.005512048,
-0.0013315529,
-0.0048549827,
0.040777873,
0.020282743,
0.006550742,
0.0074533774,
0.011004184,
0.022459688,
0.006673527,
0.022897732,
-0.02011018,
0.038521282,
-0.017455371,
0.015981952,
-0.009683417,
-0.028247172,
-0.023574706,
-0.023667626,
-0.0048417086,
0.008840515,
0.0037764662,
-0.02867194,
0.1030597,
0.02151723,
-0.018490747,
0.0072609037,
-0.012212123,
0.03562754,
0.01072543,
0.00929847,
0.0032023638,
-0.02512777,
0.013751913,
-0.023110116,
0.01630053,
-0.026229516,
-0.0142563265,
0.006252076,
0.016114693,
0.014866932,
0.008196724,
-0.015198784,
0.0015646783,
-0.016619107,
0.012105931,
0.018450925,
-0.01623416,
-0.007473288,
0.04149467,
0.0028157572,
0.0025071355,
-0.02840646,
0.0114223175,
-0.011256391,
-0.050175898,
-0.004914716,
0.0118736345,
-0.007864873,
-0.017442098,
-0.009252011,
0.023601254,
0.00085036864,
0.010811711,
0.0029219496,
-0.027875498,
-0.03623815,
0.0024158766,
-0.010373668,
-0.030132087,
-0.024689727,
-0.0039390735
] |
Telomeres protect chromosome ends from being detected as lesions and from triggering DNA damage checkpoints. Paradoxically, telomere function depends on checkpoint proteins such as ATM and ATR, but a molecular model explaining this seemingly contradictory relationship has been missing so far. Here we show that the DNA damage machinery acts on telomeres in at least two independent steps. First, the ATR-dependent machinery is recruited to telomeres before telomere replication is completed, likely in response to single-stranded DNA resulting from replication fork stalling. Second, after replication, telomeres attract ATM and the homologous recombination (HR) | [
-0.035405215,
-0.0072419755,
-0.008851304,
-0.041686784,
-0.04015533,
0.0327057,
-0.017897284,
0.014302253,
-0.007618351,
0.004471076,
0.017365167,
0.020882327,
0.002710874,
0.0073003788,
0.0026281364,
-0.0039227367,
0.036339663,
-0.012971962,
-0.008176425,
-0.0037313048,
-0.035509042,
0.013328869,
-0.0052076033,
-0.0033387064,
0.017481973,
0.012803242,
0.024451401,
-0.05053809,
-0.0076378183,
-0.006505449,
-0.0080661075,
0.010408718,
-0.01893556,
-0.017884305,
-0.020415103,
-0.00082048145,
0.01717049,
-0.0025924456,
0.010272444,
-0.041245516,
0.003139163,
-0.0010828895,
-0.0029899108,
-0.008721519,
-0.0033176166,
0.0073977173,
0.037481766,
-0.012173787,
-0.009578097,
0.0014730542,
0.0019938145,
-0.0029136622,
-0.04994108,
0.0029379968,
-0.029123643,
-0.004383472,
0.00888375,
0.0074171848,
-0.0061290734,
-0.0102075515,
-0.012556652,
-0.007131659,
-0.021219768,
0.020376168,
-0.0045197457,
0.019584483,
0.014925219,
0.0010212419,
0.008182913,
0.016794115,
0.03267974,
0.027799843,
-0.0018299617,
0.010966791,
0.006047958,
-0.0541461,
-0.010609884,
-0.0146007575,
-0.0017861594,
0.024607142,
0.023997156,
0.0054606833,
0.0007154371,
0.012913559,
0.011654649,
-0.01273835,
-0.0019078323,
-0.0054606833,
0.04347781,
0.0019565015,
0.009837666,
0.015223723,
0.023490997,
0.017871328,
-0.008040151,
0.012550162,
0.016132215,
0.02715092,
-0.026281364,
-0.017326232,
-0.029980222,
-0.015158831,
0.0036404554,
-0.005496374,
-0.015989453,
0.012666969,
0.032160603,
-0.0060317353,
-0.0035820524,
-0.034989905,
-0.025372872,
0.017481973,
-0.014107577,
-0.028267067,
0.002107376,
-0.014457994,
-0.005259517,
-0.006434067,
-0.020713609,
0.002308542,
0.030707015,
0.03410737,
0.0099739395,
-0.01700177,
0.013095257,
0.0006586564,
0.0055774893,
0.011622203,
0.0002496324,
0.003293282,
-0.00024517105,
0.030810842,
0.014211404,
0.009831177,
-0.034912035,
-0.004471076,
-0.014977133,
-0.0063334843,
-0.011557311,
-0.02899386,
0.020051707,
0.017092621,
-0.012219212,
-0.013380783,
0.00930555,
0.013873965,
-0.011031684,
0.013757158,
-0.0015468692,
0.020051707,
-0.010843496,
-0.0058727493,
0.0081894025,
-0.0138869425,
-0.0017910262,
0.010947323,
-0.017637715,
0.0036404554,
-0.022322936,
-0.016781136,
0.020661695,
-0.0002494296,
0.024152897,
0.0068656006,
0.010291912,
0.034574594,
-0.014795435,
0.023101643,
0.0155481845,
-0.008695562,
0.005898706,
0.008280252,
-0.015197766,
0.0043867165,
-0.03761155,
0.016015409,
0.0014316854,
0.01273186,
-0.032783568,
-0.02362078,
-0.020739565,
-0.0031180729,
0.017326232,
0.008182913,
-0.027618144,
0.0019613684,
0.002970443,
-0.017650694,
-0.0089161955,
-0.013964813,
0.003569074,
0.007365271,
-0.010304891,
0.0017439794,
-0.640824,
-0.008968109,
-0.008766944,
-0.021751884,
0.005665094,
0.020337233,
0.010901899,
0.009993407,
-0.024256725,
0.013328869,
-0.017300276,
-0.0026086688,
0.0154184,
-0.025684355,
-0.03688476,
-0.04350377,
0.009318528,
0.0000014892265,
0.030966584,
0.019130237,
-0.02337419,
0.0045262347,
-0.022569526,
-0.0036826355,
-0.019389806,
0.0066579455,
0.040674467,
-0.008364611,
-0.01717049,
0.032523997,
-0.019844051,
-0.015340529,
-0.025385851,
0.010188084,
0.04147913,
-0.00846195,
0.005025905,
0.00661901,
0.006359441,
0.029357256,
-0.0005499619,
0.0066319886,
0.03470438,
0.00929906,
0.007683243,
-0.005489885,
0.020350212,
-0.007501545,
0.0015371353,
0.01432821,
0.0061225845,
0.0061031166,
-0.0019419007,
0.029772567,
0.013497589,
0.036573276,
0.022232087,
-0.024178855,
0.025333937,
0.0041336366,
-0.019169172,
0.028500678,
-0.013796094,
-0.008520354,
-0.013588439,
0.0154184,
-0.00094418233,
0.0014957665,
0.010752647,
0.00930555,
0.03319888,
0.032939307,
-0.00787143,
-0.0053925463,
-0.0116351815,
0.020479996,
0.0069110254,
0.012666969,
-0.0014357412,
0.015846688,
0.010175106,
-0.010129681,
-0.00013607094,
-0.008150468,
0.023711631,
0.0017050441,
-0.015950516,
0.014354167,
-0.0058046123,
0.0025275534,
0.0086696055,
0.0143801235,
-0.024788842,
-0.020194469,
-0.015275637,
-0.0056358925,
-0.0017228894,
-0.0029785545,
-0.015690947,
-0.016080301,
-0.019389806,
-0.009337995,
-0.0056683384,
0.007949301,
0.011966132,
-0.0115118865,
-0.009175765,
0.0022744737,
0.039013226,
-0.0060025337,
-0.008611202,
0.0029201515,
-0.0143671455,
0.001249987,
0.004497033,
-0.011836347,
0.039999586,
0.019350871,
-0.00082088704,
-0.0048571853,
-0.0009668946,
-0.008027172,
0.0024869957,
-0.02421779,
0.02607371,
0.00031493022,
0.015652012,
-0.010194574,
0.015042025,
-0.01038925,
-0.005927908,
0.022309957,
0.015029047,
-0.030447446,
0.013783115,
0.00088172354,
0.0025713556,
-0.012069959,
0.02271229,
-0.040414896,
-0.030161921,
0.0024285926,
-0.0045132563,
0.0030564251,
-0.018416421,
-0.045113098,
-0.021920605,
-0.01944172,
0.0042471983,
0.0067682625,
0.0025324202,
0.015016068,
-0.017884305,
0.004834473,
-0.009454802,
-0.011446994,
0.012251657,
-0.04186848,
-0.016300935,
-0.021648057,
0.010395739,
0.0037507724,
-0.018299617,
0.019701289,
-0.010739668,
-0.006485981,
0.0108110495,
-0.0026930287,
-0.017572822,
-0.01650859,
0.0017456017,
-0.017910263,
-0.0443863,
-0.004876653,
-0.0007831684,
0.051809978,
0.0025794671,
0.007618351,
0.0019029654,
-0.016300935,
-0.0019548791,
-0.007533991,
0.007274422,
-0.026579868,
0.022777181,
0.023270363,
0.051394667,
0.005285474,
0.006343218,
0.033069093,
0.005859771,
0.008481418,
-0.013951835,
0.015275637,
0.020233406,
-0.019831073,
0.014769478,
-0.0005353611,
-0.010694244,
0.03049936,
0.0029104177,
-0.0201166,
0.0046462854,
-0.020895306,
-0.0034003542,
-0.013458653,
0.012206233,
-0.02271229,
-0.0016823317,
-0.006320506,
-0.018883646,
-0.01867599,
-0.015457335,
-0.0021008868,
0.0042179967,
0.026995178,
0.0031229397,
0.008877261,
-0.0061550303,
-0.0005528009,
-0.015509249,
-0.007923344,
0.016638374,
-0.025528613,
0.014276296,
0.012056981,
0.0042926227,
0.026865393,
-0.010434675,
-0.008650138,
0.005139467,
0.005330899,
-0.008656627,
0.022881009,
0.022777181,
0.019662354,
0.00007062103,
-0.0022485165,
0.036261793,
0.0059538647,
-0.0017731809,
0.0014592645,
-0.0019256776,
-0.027540274,
-0.0057754107,
0.00057794666,
0.05004491,
0.020557867,
0.004166083,
0.0026281364,
-0.01089541,
0.014055663,
-0.021128919,
0.003288415,
0.011297742,
-0.022219108,
0.0069824066,
0.012971962,
0.033484403,
0.0060609365,
0.028734291,
-0.0050129266,
0.0047825594,
-0.025282023,
0.0076962216,
-0.005882483,
0.0153275505,
0.0053503667,
-0.019428741,
0.0014649427,
0.012744839,
0.017494952,
0.0052984525,
-0.032446127,
0.02982448,
0.019078324,
-0.0007693788,
0.02504841,
0.002107376,
0.013835029,
-0.02186869,
-0.032160603,
0.04397099,
0.018299617,
-0.026086686,
-0.0065898085,
-0.027851757,
0.002589201,
0.015807753,
-0.00045424578,
0.0021609121,
0.024152897,
0.00972086,
0.009169276,
-0.020622758,
-0.017702607,
0.028941946,
-0.031667423,
0.028344937,
-0.01147944,
0.011356145,
0.017806435,
-0.023179514,
-0.014042684,
0.020492975,
0.010590416,
0.015794775,
0.00043234465,
-0.007916856,
-0.0327057,
0.011680606,
-0.014535865,
0.0092147,
-0.026255406,
0.0014470973,
-0.006482736,
0.007683243,
-0.0027936115,
0.0071835727,
0.016223064,
-0.025606483,
-0.01700177,
-0.006479492,
0.0017683139,
0.04472374,
0.033069093,
-0.00544446,
0.010214041,
-0.027851757,
0.025801161,
0.0052270712,
-0.03434098,
0.012056981,
-0.033354618,
-0.0039843847,
-0.016430719,
0.026839437,
0.010447653,
0.01232304,
0.014470973,
0.008585245,
-0.011245828,
-0.0016052722,
-0.0029558423,
-0.0021381998,
-0.0046689976,
0.042128053,
0.0327057,
0.021933582,
-0.017144535,
-0.0008387324,
0.018909603,
0.0029233962,
-0.008643649,
-0.018169831,
0.0012459313,
-0.008942152,
0.030810842,
-0.008987578,
-0.018961517,
0.009292571,
0.015132874,
0.012264636,
-0.005947375,
0.006073915,
-0.0066060317,
0.019545548,
0.0040395427,
-0.010499567,
0.002860126,
0.03839026,
0.008520354,
-0.010752647,
-0.010934345,
0.004104435,
-0.00922119,
-0.02572329,
-0.009370442,
0.007975258,
-0.011940175,
-0.012933026,
-0.0053828126,
-0.012069959,
-0.00064567797,
-0.003007756,
-0.025152238,
0.014795435,
0.00018980984,
0.017637715,
-0.027228791,
0.00569754,
-0.0148343695,
-0.009097895,
-0.029954266,
0.0066839023,
-0.032913353,
-0.04480161,
-0.010337336,
0.040388938,
0.010343825,
0.00922119,
-0.014198425,
-0.025827117,
0.01097328,
-0.016638374,
-0.025450742,
-0.0023847905,
-0.024568208,
-0.011966132,
-0.0007466665,
0.0087929005,
-0.0013935611,
-0.0018948539,
0.03000618,
-0.001683954,
-0.0053601004,
0.029694697,
-0.00837759,
-0.005976577,
0.018091962,
0.019247044,
0.035327345,
0.011453483,
-0.000775868,
-0.020622758,
-0.04373738,
-0.0186111,
-0.030603187,
-0.0076053725,
-0.026657738,
-0.014470973,
0.0057332306,
0.017027728,
-0.020012772,
-0.007131659,
0.005837058,
-0.018403444,
-0.015768819,
0.011206892,
-0.00028735102,
0.016975814,
0.0155481845,
-0.026865393,
-0.0024529272,
-0.013354826,
-0.032446127,
0.015223723,
0.022945901,
-0.00871503,
0.018520249,
0.0207785,
-0.02380248,
-0.016028387,
-0.014522887,
-0.0052173375,
0.015236702,
-0.011427526,
-0.03636562,
-0.012394421,
-0.009707881,
-0.01046712,
-0.0048539406,
0.01172603,
0.014224382,
-0.0059019504,
0.014990111,
-0.003958428,
-0.0035463618,
0.0069824066,
-0.024788842,
0.0040427875,
0.021051047,
0.025567548,
0.015937539,
-0.01131072,
0.009565119,
-0.033795886,
-0.006670924,
-0.006930493,
-0.028734291,
0.020311275,
-0.008059618,
0.024477359,
0.034133326,
0.024425445,
-0.023932263,
0.015989453,
0.007410696,
0.0071511264,
-0.020077664,
-0.017481973,
0.0048961206,
-0.0040103416,
0.02345206,
-0.0004903421,
-0.011174446,
0.008260784,
-0.024451401,
0.022608463,
0.027124964,
0.016820073,
-0.011434016,
0.012809731,
-0.03846813,
-0.004308846,
0.006898047,
-0.012180276,
0.0021268437,
-0.019662354,
0.013289934,
0.0169239,
0.009896069,
0.022413785,
0.009065448,
0.012744839,
0.0049675023,
0.027799843,
-0.016625395,
0.026411148,
-0.021933582,
-0.02044106,
-0.017144535,
-0.0008695562,
0.024594165,
0.008533332,
0.004500278,
0.0033614188,
-0.015106917,
-0.021401467,
0.018247703,
-0.011881772,
-0.031952947,
-0.0055710003,
-0.024931604,
-0.004166083,
-0.009513205,
0.0038189092,
-0.022595484,
0.01876684,
0.0076053725,
-0.011907729,
0.00745612,
-0.00036400498,
-0.010291912,
0.03140785,
-0.0046300623,
0.011972621,
-0.0016936879,
0.009857134,
-0.0032478573,
0.00464953,
-0.014432037,
-0.011038173,
-0.0033906205,
0.028448764,
0.026281364,
0.0018737639,
0.009286081,
-0.017507931,
-0.004510012,
-0.014341189,
-0.02051893,
-0.05110914,
-0.016949857,
-0.0130693,
0.015716905,
0.004305601,
0.009811709,
-0.009642989,
0.02086935,
0.006781241,
0.016625395,
0.019376827,
-0.018701948,
-0.01148593,
-0.0021300884,
-0.004406184,
0.028215153,
-0.0059635984,
-0.017040707,
-0.008740987,
-0.012005067,
0.011862304,
-0.0040330538,
0.00871503,
0.02831898,
-0.017793456,
-0.0011356145,
0.016145194,
-0.0051751575,
-0.0055255755,
-0.013614396,
0.012413888,
0.041998267,
-0.014432037,
-0.019831073,
-0.016690288,
-0.00018818754,
-0.0070732557,
0.0025210641,
-0.00033439792,
-0.012082938,
-0.02824111,
-0.010194574,
0.005168668,
0.014808413,
-0.011739009,
-0.02480182,
-0.018338552,
-0.003679391,
0.0019743468,
-0.0040006074,
0.017157512,
-0.054665238,
-0.029435128,
0.008637159,
0.010934345,
0.02857855,
0.012193255,
0.015405421,
-0.017728563,
0.037403896,
-0.012530695,
0.0053503667,
-0.0021966028,
-0.0080790855,
-0.014341189,
-0.0033484404,
-0.004279644,
-0.026099665,
0.0040265643,
-0.0017585801,
-0.025814138,
-0.014432037,
-0.0034490235,
0.017118577,
0.0068591116,
-0.04114169,
0.015626054,
-0.01072669,
0.0062166783,
0.0038546,
-0.02388035,
0.018831732,
-0.033354618,
0.010532013,
0.030577231,
-0.02403609,
-0.00018778196,
-0.008033661,
-0.020973178,
0.008351633,
-0.0019208108,
-0.015716905,
-0.013328869,
-0.022271022,
-0.010882432,
-0.004766336,
-0.015574141,
-0.00045789598,
-0.01735219,
0.0007470721,
-0.021505294,
0.0026800502,
-0.0048085162,
0.026657738,
-0.0012913559,
0.009149808,
-0.023672694,
0.0035852971,
0.0044386303,
0.00063269946,
-0.031563595,
-0.006846133,
-0.01105764,
0.02245272,
0.008260784,
-0.0021722682,
-0.0032657029,
-0.0069434713,
-0.03317292,
-0.032082733,
-0.0018186055,
0.008429504,
0.016716246,
0.01683305,
-0.00544446,
0.020583823,
0.0136533305,
0.014146511,
0.012835688,
-0.022686332,
0.014302253,
-0.00043964502,
0.03008405,
0.013432696,
-0.026034772,
0.0045132563,
0.015846688,
-0.012576119,
-0.018585142,
0.018299617,
0.0034782249,
0.019636396,
0.0013846385,
0.009227679,
-0.001313257,
0.015132874,
0.011609225,
-0.020622758,
-0.01005181,
-0.0023637004,
0.007761114,
-0.013510568,
0.018650034,
-0.005363345,
0.008734497,
0.0032640805,
-0.026631782,
-0.044568002,
-0.002339366,
-0.03813069,
0.03527543,
0.026294341,
0.0069759176,
0.011920707,
0.00029688206,
-0.02303675,
-0.0029720652,
-0.01884471,
-0.025295,
0.002944486,
0.012361974,
-0.0015712037,
-0.012887602,
-0.0020295053,
0.014198425,
-0.0073003788,
0.015535206,
-0.0033387064,
-0.026683696,
-0.026761565,
0.020570844,
-0.00026585546,
0.015379464,
0.0027887446,
0.013147171,
-0.02816324,
-0.016677309,
0.013023876,
-0.01658646,
-0.003494448,
0.008663116,
-0.0040654996,
-0.0020197714,
0.006554118,
-0.010181595,
-0.005437971,
-0.021466358,
-0.013718223,
0.19758394,
-0.027021136,
-0.021232747,
0.006073915,
-0.009071938,
0.0022112036,
0.004071989,
0.006651456,
-0.033743974,
-0.00098474,
0.010733179,
0.0046722423,
-0.0049415454,
-0.0032040551,
0.017196449,
-0.019805117,
-0.0008614447,
0.017715586,
-0.015833711,
0.010525524,
0.023023773,
-0.026268385,
-0.0038967798,
-0.0071770833,
0.02555457,
0.006651456,
-0.008306209,
-0.008338654,
0.002478884,
0.004561926,
-0.041531045,
-0.009870112,
0.011421037,
-0.00038083643,
-0.0067487946,
-0.0029233962,
-0.029357256,
-0.010486589,
0.0014657538,
-0.009084916,
0.011550821,
-0.0012994674,
-0.011291252,
-0.013263977,
-0.0044386303,
0.009831177,
-0.0049642576,
-0.030732973,
-0.007527502,
0.0075145233,
-0.046047546,
0.0019954368,
0.005645626,
0.01675518,
-0.0010301645,
0.0058111013,
0.008760454,
-0.0112782745,
-0.019831073,
0.009539162,
-0.008948642,
0.011836347,
-0.02446438,
0.0041790614,
-0.037326027,
0.021219768,
-0.017468994,
0.025749248,
0.03483416,
-0.034237154,
0.008637159,
0.0022063367,
-0.004308846,
-0.012173787,
0.004467832,
-0.027254747,
0.039765973,
0.008351633,
0.011498908,
0.007047299,
0.012796753,
-0.009513205,
-0.009169276,
0.007086234,
0.018312594,
-0.014016727,
0.03763751,
0.013049833,
0.0022582505,
-0.0034295558,
-0.0010407096,
-0.0169239,
-0.009655967,
0.0027352085,
-0.0017245117,
-0.0063075274,
0.0010707222,
0.011336677,
-0.004123903,
-0.02002575,
-0.02959087,
0.05144658,
-0.011369123,
-0.004977236,
-0.007079745,
0.015016068,
-0.005145956,
0.03561287,
-0.00507133,
-0.033795886,
0.020194469,
-0.023841415,
0.02195954,
-0.00025166027,
-0.011472951,
0.01348461,
0.015496271,
-0.027462402,
0.032653783,
-0.008001215,
0.0041174134,
-0.013731201,
-0.0060090227,
0.023439083,
-0.009662457,
-0.0067228377,
-0.03361419,
0.005470417,
0.0056002014,
-0.010765625,
-0.010752647,
0.01089541,
0.0007677565,
0.0119920885,
0.006301038,
-0.019597461,
0.019363848,
-0.024685014,
-0.016612418,
0.004331558,
-0.0028033454,
-0.0035074265,
-0.0016158172,
0.008319187,
-0.0028293023,
-0.01741708,
0.012420378,
0.015872646,
-0.02748836,
-0.029902352,
-0.014717564,
-0.0017066663,
-0.00787143,
0.012264636,
-0.0201166,
-0.04332207,
-0.002345855,
-0.035015862,
-0.00064365007,
0.0034295558,
-0.002916907,
0.01223219,
0.012861645,
0.000035310513,
-0.0055028633,
0.016716246,
-0.16114044,
0.005691051,
0.008552799,
-0.024957562,
0.02798154,
0.026761565,
0.020622758,
0.015820732,
-0.005162179,
0.038675785,
0.021570185,
0.0109083885,
-0.027047092,
-0.024607142,
-0.0034652464,
0.0044451193,
0.0098506445,
0.020999134,
0.034574594,
-0.0061777425,
-0.002392902,
-0.031200197,
0.032731652,
0.0047144224,
0.0042244857,
0.01801409,
-0.004584638,
-0.004617084,
-0.0005661849,
-0.0078324955,
-0.003935715,
0.0039778952,
0.023179514,
-0.019117258,
0.012511227,
0.008864282,
-0.008676095,
-0.0069369823,
0.0024496827,
-0.0025648663,
0.028033454,
0.015470314,
0.0050583514,
-0.009422355,
0.011914218,
0.03730007,
0.0024367042,
-0.03903918,
0.026579868,
-0.024165876,
0.039688103,
-0.026177537,
0.0061874767,
0.020428082,
0.001059366,
-0.023088664,
-0.023049729,
0.00678773,
0.006846133,
-0.004464587,
-0.008260784,
0.0044808104,
0.027254747,
-0.007131659,
0.012660479,
-0.0150809605,
-0.0058500366,
0.011972621,
-0.036729015,
0.017326232,
-0.010960302,
-0.010538503,
0.016067322,
-0.021596143,
-0.011109554,
0.019402785,
-0.0155481845,
0.018130897,
-0.020090641,
-0.026281364,
-0.009947983,
0.028500678,
-0.015639033,
-0.020428082,
-0.013848008,
-0.011751987,
-0.015600098,
0.022167195,
-0.02271229,
0.004633307,
0.017313253,
0.0041174134,
0.002212826,
-0.01700177,
0.0340295,
0.034133326,
-0.0015184787,
-0.016326891,
0.005019416,
0.0019483899,
-0.0024626611,
-0.0072354865,
-0.0126475,
0.0075210123,
0.020324254,
0.025074368,
0.0046430407,
0.000741394,
0.028474722,
0.012563141,
-0.025619462,
-0.023114622,
-0.0029720652,
0.019273,
0.028474722,
0.027254747,
-0.0022517613,
-0.005210848,
-0.013315891,
-0.0024383266,
0.06411355,
-0.0034003542,
-0.0201166,
0.018027069,
0.005720252,
-0.004464587,
-0.13445675,
-0.0058208355,
0.004500278,
0.026125623,
0.016456677,
0.017040707,
0.0012288971,
0.04809814,
-0.015703926,
0.030161921,
-0.03727411,
-0.008345144,
-0.007864941,
-0.011038173,
-0.030862756,
-0.02446438,
0.0014616981,
0.00002740177,
-0.010194574,
0.027358575,
-0.001789404,
-0.014483951,
0.0045716595,
-0.023724608,
-0.00013840302,
-0.005742965,
-0.02497054,
0.019065345,
0.010622862,
0.013088768,
-0.018208766,
-0.012615055,
-0.0045684148,
0.00096770574,
-0.017404104,
-0.02506139,
-0.0153275505,
-0.04020724,
0.043451853,
0.0042958674,
-0.01633987,
0.003462002,
0.013367805,
-0.0046657533,
0.023400147,
-0.031978905,
-0.0068850685,
0.023776522,
-0.0012808109,
0.0032105444,
-0.032913353,
-0.011622203,
-0.046592638,
-0.011888261,
0.011751987,
-0.01575584,
0.009818198,
0.021622099,
0.0030142453,
-0.00829972,
-0.00704081,
-0.0076572862,
0.009402888,
-0.0012029402,
0.032368258,
-0.014769478,
-0.003335462,
-0.018533228,
0.04373738,
0.008202381,
0.0057072737,
-0.009993407,
-0.018520249,
-0.0046397964,
-0.0042017736,
-0.0030856268,
-0.017326232,
-0.02027234,
0.014977133,
-0.014068641,
0.014457994,
-0.019415762,
0.017157512,
-0.018286638,
0.025113303,
-0.022478677,
-0.011881772,
0.00084684393,
0.0061517856,
-0.016560504,
0.0011380479,
0.070187464,
-0.016884964,
0.004169327,
-0.006440556,
0.02028532,
-0.0046365517,
0.0029006838,
0.02689135,
0.016690288,
-0.014120555,
-0.004441875,
-0.049058545,
0.015379464,
0.016015409,
0.0048539406,
-0.011459973,
0.009811709,
0.02790367,
0.00036197712,
0.0143801235,
0.02002575,
-0.015807753,
0.020246383,
-0.0072160186,
-0.013140682,
-0.03325079,
-0.019636396,
0.022906967,
-0.006644967,
0.024165876,
0.028526636,
-0.014626714,
0.0065184273,
0.0037702401,
0.01987001,
0.028293023,
-0.016197108,
-0.006761773,
0.009350974,
-0.010882432,
0.00586626,
0.0261386,
-0.011083597,
-0.017832391,
-0.01718347,
-0.0066839023,
0.010480099,
-0.043867163,
0.0004907477,
0.024516294,
0.011596246,
-0.03140785,
-0.032653783,
0.01902641,
0.0020213937,
-0.018637056,
0.0014097843,
-0.02504841,
0.006593053,
0.004685221,
-0.025801161,
0.029642783,
0.012881112,
0.0017504686,
-0.020479996,
-0.011161468,
-0.0067228377,
0.018818755,
-0.015911581,
-0.00022103924,
-0.03644349,
0.008929174,
0.029279387,
-0.0005292775,
0.006317261,
0.00072030403,
-0.0010139415,
-0.023400147,
-0.007365271,
-0.009558629,
-0.019221086,
-0.009357464,
0.041349344,
0.008611202,
-0.0006566285,
0.007903877,
-0.0097273495,
-0.03981789,
-0.005214093,
-0.007248465,
-0.008442482,
0.00011528515,
0.009084916,
-0.02070063,
0.015353507,
0.038338345,
-0.018104939,
-0.00026423315,
0.019428741,
-0.007014853,
0.008072597,
-0.00073206576,
0.013289934,
0.008474928,
0.006417844,
0.0053601004,
0.025035432,
-0.0100842565,
-0.007838984,
-0.003997363,
0.015067982,
0.023478018,
-0.023815459,
-0.012355485,
0.009493737,
-0.0033322172,
0.035405215,
-0.008526842,
-0.03979193,
0.008702052,
0.014886283,
0.017391125,
0.010668287,
0.04057064,
-0.0027124963,
0.006485981,
0.029668739,
-0.006116095,
0.0065638516,
0.00026403036,
-0.00829323,
0.021920605,
0.021686992,
-0.006781241,
0.0045489473,
0.03148572,
0.025502656,
0.020129578,
-0.023919286,
0.018040048,
-0.0007353104,
0.050226606,
0.0045878827,
-0.03896131,
-0.009422355,
0.00027416978,
0.0040654996,
0.009857134,
0.027462402,
-0.016949857,
0.07906473,
0.026099665,
-0.0042763995,
0.013212063,
-0.032316342,
0.028370894,
0.012465802,
0.012050492,
-0.028682377,
-0.03753368,
0.022309957,
-0.0058727493,
0.015106917,
-0.01089541,
0.0016742202,
0.026450083,
-0.0037442832,
-0.006586564,
-0.0034879588,
-0.04726752,
0.0019483899,
-0.027799843,
-0.0085463105,
0.02177784,
-0.0008492774,
0.0010617996,
0.016391784,
0.0029347523,
0.022868032,
-0.022673354,
0.02171295,
-0.022426764,
-0.023867372,
0.008624181,
0.015729882,
0.004007097,
-0.016236043,
-0.024451401,
0.045554362,
0.018117918,
-0.0067747515,
0.008974599,
-0.0037929523,
-0.029019816,
0.0086696055,
0.017572822,
0.027332619,
-0.011687095,
0.014172468
] |
Satellite cells are skeletal muscle stem cells capable of self-renewal and differentiation after transplantation, but whether they contribute to endogenous muscle fiber repair has been unclear. The transcription factor Pax7 marks satellite cells and is critical for establishing the adult satellite cell pool. By using a lineage tracing approach, we show that after injury, quiescent adult Pax7(+) cells enter the cell cycle; a subpopulation returns to quiescence to replenish the satellite cell compartment, while others contribute to muscle fiber formation. We demonstrate that Sprouty1 (Spry1), a receptor tyrosine kinase signaling inhibitor, is expressed in qu | [
-0.0030004394,
-0.004536018,
-0.014453296,
-0.017618742,
-0.042565156,
0.0036571012,
-0.012055637,
0.007954027,
-0.0106143495,
0.009294291,
0.031061789,
0.0064251833,
-0.0036941438,
0.010728844,
-0.013402636,
-0.014022256,
0.030469108,
-0.010499855,
-0.00095636904,
0.009179796,
0.0039635436,
0.0027377747,
-0.014035726,
-0.0015246341,
0.008816106,
0.017578332,
0.0056809667,
-0.014614935,
-0.021161348,
-0.014049196,
0.008971011,
-0.004209371,
-0.008499562,
-0.018278772,
-0.0052229874,
-0.012365447,
0.000019402569,
-0.027330602,
-0.0024868962,
-0.0025104687,
0.035830162,
0.016029283,
-0.0062770136,
-0.022912446,
0.0034297954,
-0.013375697,
-0.0149516845,
-0.017430162,
0.009772475,
0.0131197665,
0.018575111,
-0.0011457907,
-0.035695463,
0.023990046,
-0.031438947,
-0.0066474383,
0.013267936,
0.023101026,
0.0074017574,
-0.011907468,
0.0040174234,
0.00040704614,
-0.006354466,
-0.008142606,
-0.0011247438,
0.015059445,
0.0017477308,
0.0002103633,
-0.00028707908,
-0.013126502,
0.03003807,
0.014264716,
0.01002167,
-0.02812533,
0.0043844804,
-0.02074378,
-0.004522548,
-0.009462666,
-0.021511568,
-0.0124260625,
0.011025184,
-0.012479942,
-0.024084335,
0.041056518,
0.015638655,
-0.011638069,
-0.0097859455,
0.01955842,
-0.0018234994,
0.01970659,
0.01943719,
0.035156664,
0.014049196,
0.00996779,
-0.014830455,
0.014116546,
-0.008667937,
0.016298683,
-0.025242755,
-0.014601465,
-0.015369254,
0.014318596,
-0.016392974,
-0.0194776,
-0.035102785,
0.034563985,
0.0114629585,
0.001986823,
0.034052126,
-0.0037008787,
-0.022414057,
0.011873793,
-0.017093413,
-0.035964865,
0.02058214,
-0.0120017575,
0.035237484,
0.021794438,
-0.027034262,
-0.0059436313,
0.034510106,
0.015301905,
0.021174818,
-0.027990632,
0.02112094,
0.022562226,
0.0026316985,
0.030819329,
-0.020676428,
0.011934408,
-0.025310105,
0.017255053,
0.009402051,
0.0139683755,
-0.00983309,
-0.022036897,
-0.00950981,
0.0064319186,
-0.025808495,
-0.04040996,
-0.012917717,
0.012904247,
-0.014587996,
0.004536018,
-0.0008241948,
-0.027748171,
0.021605859,
0.0018201319,
0.03203163,
0.0021164715,
0.01965271,
0.006226501,
0.014924745,
-0.0121364575,
-0.018575111,
0.010701904,
-0.0057887267,
0.015975405,
-0.012722402,
-0.021134408,
-0.006509371,
-0.014426355,
0.016850952,
-0.015463544,
0.0062231338,
0.01922167,
0.0076711574,
0.007091948,
0.0017233164,
-0.009381846,
0.0011053807,
0.03141201,
-0.03195081,
0.017686091,
-0.025161935,
0.009543485,
-0.024326796,
0.012527088,
-0.044127677,
-0.016069693,
-0.02077072,
0.022912446,
0.025875844,
0.006014349,
-0.0005101757,
-0.008573647,
0.017147293,
-0.02971479,
-0.015934994,
-0.022373646,
0.01924861,
-0.0050647147,
-0.011880528,
-0.008465886,
-0.62371427,
-0.024165155,
0.017389752,
0.0012518668,
0.02077072,
0.036449783,
0.008614056,
-0.015261495,
-0.032920647,
0.006654173,
-0.008587116,
0.02912211,
0.00085786975,
-0.0052196197,
-0.023101026,
-0.025525624,
-0.009159591,
-0.0129850665,
0.034213766,
0.0054755495,
0.0074421675,
0.007071743,
-0.0076307473,
0.045959592,
0.024488436,
0.030549929,
0.011321523,
-0.008075257,
-0.014210836,
0.025040705,
-0.010863544,
0.033459447,
0.003451684,
0.00093616406,
0.03968258,
0.01889839,
-0.023855345,
0.0045259153,
0.0003190703,
0.045959592,
-0.005859444,
0.0023404101,
0.011577453,
-0.0071256226,
-0.02104012,
0.0013899342,
-0.00972533,
-0.00034243232,
-0.018009372,
-0.01829224,
0.030657688,
0.0028051247,
-0.024932945,
0.013214056,
0.025431335,
0.013665301,
0.015786825,
0.005526062,
-0.017618742,
0.012358712,
0.00959063,
0.03725798,
-0.00971186,
-0.003785066,
0.005893119,
0.01916779,
-0.02906823,
-0.0046134703,
0.016756663,
-0.024353735,
0.01904656,
0.021767497,
-0.022737337,
0.0092067355,
-0.00019941894,
0.032274086,
-0.013995316,
-0.003960176,
0.0036234264,
0.014911274,
-0.0082234265,
-0.034375407,
-0.009907175,
0.010964569,
0.032193266,
-0.0010540264,
-0.034833387,
0.022171598,
0.0063308934,
0.013449782,
-0.0024582725,
0.005010835,
0.007873207,
-0.04754905,
-0.026428113,
0.024757834,
-0.008142606,
0.00018868504,
0.0052532945,
-0.021134408,
-0.016150514,
0.01949107,
0.02785593,
0.0026148611,
0.032301027,
0.024515375,
-0.037608203,
-0.0012678625,
0.017901612,
-0.046175115,
0.027168963,
0.0023656664,
-0.005209517,
-0.006657541,
0.0032277454,
-0.023087557,
0.026455054,
0.005189312,
-0.016002344,
-0.008748756,
-0.0005004942,
-0.016689314,
0.018036311,
0.01844041,
0.0128503665,
0.006889898,
-0.009361641,
-0.0048997076,
0.022764277,
-0.010136165,
-0.026751393,
0.0098735,
0.030900149,
-0.016770134,
0.023437776,
-0.02054173,
0.0026721086,
0.0036200588,
0.03232797,
-0.025754614,
-0.03954788,
-0.018696342,
-0.00073748175,
-0.016635433,
-0.010755784,
-0.0064386535,
-0.013597951,
-0.006260176,
0.001410981,
0.017039532,
-0.032489605,
-0.011422548,
-0.024919474,
0.027397953,
0.008418742,
-0.011624598,
0.0012165081,
-0.035048906,
0.011186823,
-0.023087557,
-0.02869107,
0.017632212,
-0.008977746,
0.025916254,
-0.009368376,
-0.032516547,
-0.024865596,
0.012944656,
-0.013887556,
-0.016999124,
0.007826062,
-0.022023428,
-0.015584774,
0.00991391,
-0.011799708,
0.007085213,
0.0085130315,
0.0196123,
-0.00901142,
-0.008950806,
-0.01891186,
-0.015692534,
0.0007480052,
-0.004495608,
0.014614935,
0.020959299,
0.026441583,
0.014992095,
0.00015206351,
-0.00018163434,
-0.013086092,
0.014668815,
-0.026724452,
0.013422841,
0.010573939,
-0.04008668,
0.016999124,
0.0038120062,
0.0027613472,
0.010850074,
0.005478917,
-0.027276723,
0.016702782,
-0.0071188877,
0.02785593,
-0.027263252,
-0.004344071,
-0.0150863845,
0.0051152273,
0.0027495609,
0.007886677,
0.00061288435,
-0.026401173,
-0.007832797,
0.0013865667,
0.005492387,
-0.011159884,
-0.009072036,
-0.010930894,
-0.0072535877,
-0.012331773,
0.002848902,
0.011011714,
0.0006381406,
-0.0055092243,
0.033755787,
0.007873207,
0.020528259,
0.0014951684,
0.0030492682,
-0.0001802663,
0.00085450226,
0.023680236,
0.015126795,
0.01864246,
0.016850952,
0.026616693,
0.0072199125,
0.02960703,
-0.008728551,
0.016204394,
0.009678185,
-0.015423134,
-0.01015637,
0.0021720354,
-0.017753443,
0.04116428,
-0.0146822855,
0.009072036,
0.02051479,
-0.01927555,
0.0019363106,
-0.005620352,
0.009193266,
-0.015490484,
-0.0092067355,
-0.0052196197,
0.00490981,
0.017942023,
0.010493119,
0.026684042,
0.00081325043,
0.0012569181,
0.013214056,
0.012028698,
0.008257101,
0.002047438,
-0.009354905,
-0.0002489843,
0.005946999,
-0.026239533,
0.0155308945,
0.012311568,
-0.024394145,
0.015099855,
-0.0012383969,
0.025512153,
0.023774525,
0.011193559,
0.007657687,
-0.01989517,
-0.035210546,
0.03970952,
0.016972182,
-0.012129723,
0.0054755495,
-0.036773063,
-0.013604687,
-0.010163105,
0.00007424277,
-0.011483164,
0.008284042,
-0.00992738,
-0.010971304,
-0.0206899,
-0.008775696,
0.023990046,
0.0052869697,
0.02993031,
-0.012897512,
-0.00995432,
-0.0134295765,
-0.006586823,
-0.00023467242,
0.0407063,
-0.007637482,
0.004232943,
-0.0005712116,
-0.020447439,
-0.027748171,
-0.015706005,
-0.027155492,
-0.018467352,
0.007159298,
-0.0043777456,
-0.015140264,
0.0097388,
-0.0009555272,
0.034590926,
0.011112738,
-0.016473792,
-0.026886092,
-0.002976867,
-0.022669988,
0.043050077,
0.02984949,
-0.0018521231,
0.0009807834,
-0.008149342,
-0.0021282579,
-0.0062096636,
-0.008236896,
0.029903369,
-0.01949107,
0.0057483166,
0.0057887267,
-0.021201758,
-0.0015835653,
0.004956955,
0.028448611,
-0.00910571,
-0.0004554539,
-0.022306297,
-0.026158713,
0.0008991216,
0.02112094,
0.008876721,
0.045205273,
0.04873441,
-0.013752856,
0.009880235,
0.006748463,
0.017551392,
-0.014224306,
-0.023774525,
0.012513617,
-0.0042363107,
0.006950513,
0.0082032215,
-0.025835434,
-0.0101429,
0.0062568085,
0.011052124,
0.003431479,
0.027586533,
0.010540265,
0.021713618,
0.0074623725,
0.023154907,
0.0107490495,
-0.003190703,
-0.009119181,
-0.009503075,
-0.016999124,
0.022925917,
-0.02054173,
-0.002855637,
-0.006058126,
0.01965271,
-0.0019060031,
-0.003865886,
-0.0155308945,
-0.010439239,
-0.003337189,
-0.0114427535,
-0.0097388,
0.012783017,
0.0027849197,
-0.017187703,
-0.006896633,
0.011604393,
-0.006829283,
-0.021807907,
0.0020895316,
0.014695755,
-0.031977747,
-0.02831391,
-0.0089171305,
0.031358127,
0.04224188,
0.032301027,
-0.0023606152,
-0.022575697,
0.019073501,
0.016675843,
-0.029095171,
-0.014749635,
-0.033782724,
-0.003919766,
0.009812885,
0.02104012,
0.000675604,
-0.0062702787,
-0.0036099562,
0.037769843,
-0.016339093,
-0.005169107,
-0.017214643,
-0.010028405,
0.016541144,
0.03795842,
0.0016551246,
0.012419327,
0.0060985363,
-0.025646854,
-0.038685802,
-0.003003807,
-0.007704832,
0.00030454798,
-0.0065666186,
-0.0004240941,
0.012877307,
-0.00959063,
-0.044181556,
0.007987702,
0.003397804,
0.014439825,
-0.003818741,
0.008028111,
0.012473207,
0.013416107,
0.0062366035,
-0.004660615,
-0.0056136167,
-0.009260615,
-0.020918889,
0.026024014,
-0.016473792,
-0.033351686,
-0.0047986824,
0.009361641,
0.000039226074,
-0.016797073,
-0.0068797953,
-0.0060244515,
0.0413798,
-0.013981846,
-0.024165155,
-0.019989459,
-0.00945593,
-0.009408785,
0.027438363,
0.015423134,
0.007758712,
-0.014385945,
0.02036662,
0.0062130312,
-0.0018857981,
0.027371012,
-0.032920647,
-0.0060648615,
0.037311863,
0.021578917,
0.008304247,
-0.003478624,
0.021498099,
0.02013763,
-0.0014135067,
-0.0014825404,
-0.040436897,
0.008977746,
-0.012122988,
0.0389552,
0.024421085,
0.035560764,
0.0417839,
0.002220864,
0.03033441,
0.0008477673,
-0.0012122988,
-0.021336459,
0.021565448,
-0.007805857,
0.012823427,
-0.009422256,
0.0062568085,
0.011799708,
-0.03954788,
0.0021198392,
0.035479944,
-0.033082288,
0.0037446562,
0.021673208,
-0.03930542,
-0.028367791,
0.015328844,
-0.0067114206,
0.004209371,
-0.02931069,
0.021983018,
0.026320353,
-0.0011205345,
-0.010506589,
0.010870279,
0.021161348,
-0.0036975113,
0.051940266,
0.002562665,
0.0003706351,
-0.0023185215,
-0.013342021,
0.008183016,
-0.00019699855,
0.0028623722,
0.006775403,
0.0013251099,
-0.013860616,
0.011254174,
-0.009078771,
0.0194776,
-0.012560762,
-0.02955315,
-0.014749635,
-0.035884045,
-0.02126911,
-0.012884042,
-0.026347293,
-0.022212008,
-0.0041959006,
-0.0012847,
-0.021107469,
-0.0022461202,
-0.00928082,
-0.021322988,
0.03114261,
-0.01946413,
0.014170426,
0.0029953881,
0.011287848,
0.043723576,
0.007805857,
-0.004970425,
-0.022036897,
-0.016015815,
-0.0058897515,
0.027936751,
0.007832797,
-0.007139093,
-0.03696164,
0.004845828,
0.011422548,
-0.012836897,
-0.016716253,
0.007455637,
0.0048188874,
0.011786238,
-0.003579649,
0.0015945096,
-0.02968785,
-0.008162811,
-0.014614935,
-0.0005101757,
0.009651246,
0.009812885,
-0.01946413,
0.024528844,
-0.006381406,
0.0065969257,
-0.004589898,
-0.0056877015,
-0.016635433,
-0.01924861,
-0.02062255,
-0.0021164715,
0.0058560767,
0.02893353,
-0.036907762,
0.015328844,
0.017995901,
0.022225477,
-0.0013865667,
-0.0028000735,
-0.0072603226,
0.03873968,
-0.013995316,
0.0036840413,
0.0034028552,
0.004209371,
0.014426355,
-0.015894584,
-0.006152416,
0.004007321,
-0.021067059,
-0.017241582,
0.044235434,
0.0027798684,
-0.004522548,
0.000044435168,
-0.031196488,
-0.02812533,
-0.025377454,
-0.024380675,
0.0032159593,
-0.042942315,
-0.016069693,
0.017524453,
0.024973355,
0.011543779,
-0.0007618961,
0.0072872625,
-0.0064790635,
0.024205565,
0.0011592607,
0.023949636,
0.008452416,
0.0071727675,
-0.043508057,
0.024582725,
-0.0015557834,
-0.023464717,
0.0014682285,
-0.016298683,
-0.020568669,
0.0044046855,
0.011914203,
0.021161348,
-0.00914612,
-0.0035426065,
0.016190924,
0.022656517,
0.018224891,
0.003785066,
-0.0022831627,
0.005741582,
-0.028017571,
-0.013887556,
-0.011355199,
-0.01007555,
-0.008775696,
-0.028206151,
-0.008910396,
0.0153961945,
-0.0046067354,
-0.018588582,
-0.016904833,
-0.0023185215,
-0.023559006,
-0.0103247445,
0.00086207915,
-0.023154907,
-0.005839239,
0.010688434,
-0.0038288436,
-0.0045259153,
-0.008964276,
0.022212008,
0.009839825,
0.015503954,
-0.021834848,
0.014709225,
0.011469693,
-0.034590926,
-0.015706005,
-0.004495608,
-0.026333824,
0.032112446,
0.008129137,
-0.006701318,
-0.03025359,
-0.007617277,
-0.046686973,
-0.014345535,
0.013456516,
-0.008701611,
0.0032546856,
0.022845097,
-0.026724452,
-0.010533529,
-0.017942023,
0.0073680826,
0.008580381,
-0.015867643,
0.027168963,
0.007920352,
-0.0034920939,
-0.011893998,
-0.03887438,
-0.028286971,
0.005714642,
0.0065497807,
0.009503075,
-0.0035089315,
-0.024906004,
0.032354906,
-0.008836311,
0.033190046,
0.03995198,
0.015005565,
0.007731772,
-0.023559006,
0.015732944,
0.013901026,
-0.0025222548,
-0.0141030755,
-0.0002481424,
0.012951392,
0.001959883,
0.0048694,
-0.0010523427,
-0.025269695,
-0.00075095176,
0.012197073,
0.033540267,
-0.0045461203,
-0.0022663253,
0.022090778,
0.008075257,
-0.019113911,
-0.020676428,
-0.0073815524,
-0.0018218156,
0.0060244515,
-0.005573207,
-0.009024891,
-0.0002750824,
0.0036200588,
-0.011590923,
-0.015881114,
-0.01821142,
-0.0068595908,
-0.011355199,
-0.014938215,
0.01973353,
-0.016258273,
-0.017066473,
-0.017524453,
0.0066609085,
-0.0008039898,
-0.012769547,
0.0041117133,
-0.00991391,
-0.016042754,
-0.00026098097,
-0.017510982,
-0.00042388364,
-0.026697513,
0.011436018,
0.0016610177,
0.003613324,
0.032812886,
0.20733003,
-0.0012779649,
-0.006347731,
0.006937043,
0.019073501,
0.01972006,
0.022090778,
0.0026148611,
-0.02904129,
-0.009866765,
0.0055294293,
0.013133237,
0.012823427,
-0.0109982435,
0.041433677,
-0.010082285,
-0.0039298683,
-0.010533529,
-0.014156955,
-0.031762227,
0.0055833096,
-0.015611714,
0.016339093,
0.0074084923,
0.023990046,
-0.010304539,
-0.014614935,
-0.019989459,
0.024340264,
0.027990632,
-0.02912211,
0.016258273,
-0.006970718,
0.012668522,
0.01802284,
0.010580674,
-0.012028698,
0.003076208,
0.019571891,
0.017928552,
0.025700733,
-0.010789459,
-0.0014387629,
0.007038068,
-0.02134993,
-0.001571779,
-0.011968083,
0.0106143495,
-0.00519268,
0.015248025,
-0.043669697,
0.0060951686,
0.02023192,
0.00030875736,
-0.0008721816,
0.004071303,
0.0141030755,
0.021915669,
-0.0042565158,
0.02869107,
-0.02023192,
0.013752856,
-0.043077018,
0.024636606,
-0.018400002,
0.011968083,
0.007974232,
0.0024262813,
0.024474965,
-0.026993852,
-0.01015637,
-0.012190337,
-0.009624305,
-0.006226501,
-0.002101318,
-0.007940557,
0.0010472914,
-0.012668522,
0.0032193267,
0.0021349927,
0.0152210845,
-0.004182431,
-0.024784775,
0.0020390193,
0.021498099,
-0.02896047,
0.020407028,
0.013901026,
-0.024986824,
-0.022373646,
0.011920938,
-0.024111275,
0.013375697,
-0.007617277,
0.0052229874,
-0.01993558,
-0.0063713035,
0.018184481,
-0.021578917,
-0.0080685215,
-0.024138216,
0.06357834,
0.005893119,
0.020986238,
-0.001364678,
0.012863837,
0.0039837486,
-0.014965155,
-0.035075843,
-0.020784188,
0.010903954,
-0.02070337,
0.016217863,
0.0008039898,
-0.022440998,
0.0018302344,
0.03162753,
-0.01885798,
0.06815813,
-0.007954027,
-0.007725037,
-0.0011154832,
-0.0004127288,
0.01928902,
-0.017093413,
-0.015652124,
-0.030711569,
-0.015571305,
-0.0030223283,
-0.037554324,
-0.017039532,
-0.012789752,
0.011974818,
-0.008634261,
0.013207322,
-0.0023858713,
0.00026939972,
-0.0066171307,
-0.013820206,
0.02093236,
0.0030475843,
-0.023868816,
0.023222256,
0.00996779,
0.02093236,
-0.012372183,
0.012978332,
0.03154671,
-0.013954906,
-0.017807322,
-0.009287556,
-0.006724891,
-0.012035433,
0.013779796,
0.018426942,
0.0014741216,
-0.016756663,
-0.023545535,
-0.005519327,
0.024124745,
-0.011941143,
0.03141201,
-0.009408785,
-0.014641875,
-0.017915081,
-0.011119474,
-0.17036839,
-0.00038494696,
0.011792973,
-0.01862899,
0.032570425,
-0.01065476,
0.032543488,
-0.0028084922,
-0.01922167,
0.013503661,
0.011739093,
0.002227599,
-0.033917427,
-0.012190337,
-0.008129137,
0.026872622,
0.0063005863,
0.032759007,
0.02036662,
0.036368962,
0.03879356,
-0.0015532578,
0.010863544,
-0.007058273,
0.014520645,
-0.021821378,
-0.00041651723,
-0.011611128,
-0.015342315,
-0.02906823,
-0.005805564,
-0.0041049784,
0.045501612,
-0.018736752,
0.011233969,
-0.008822841,
-0.014749635,
-0.013739386,
0.008667937,
0.02005681,
0.022845097,
0.017591802,
-0.0065531484,
0.011947878,
-0.0064117135,
0.020178039,
-0.01916779,
-0.0144128855,
0.034752566,
-0.023787996,
0.001351208,
-0.013214056,
0.015759883,
0.020258859,
0.015059445,
0.01906003,
0.014183896,
0.0012838581,
0.00024098647,
0.0026771598,
0.00029865486,
0.010573939,
0.024192095,
-0.00124429,
0.0020962667,
-0.030738508,
0.0008923866,
-0.0033456078,
-0.035156664,
0.020878479,
-0.027195903,
-0.018103661,
0.006795608,
-0.016339093,
0.016675843,
0.0017713032,
-0.0024532212,
0.007085213,
-0.008640996,
-0.0060985363,
-0.01806325,
0.025943194,
-0.013725916,
-0.017861202,
-0.0022781114,
0.011429284,
0.013456516,
0.004983895,
0.0065329433,
-0.007873207,
0.008162811,
-0.010493119,
0.00067728775,
-0.00074674236,
0.024906004,
0.024838654,
-0.02066296,
0.00008113562,
0.00065708277,
0.004876135,
0.023249196,
-0.011860323,
-0.026158713,
0.011530308,
0.025094584,
-0.010513324,
-0.026657103,
0.020447439,
0.030442169,
-0.00005872072,
0.0118670575,
-0.008681406,
0.026670573,
0.020070279,
-0.0030879944,
0.001364678,
-0.0057483166,
-0.010782724,
0.008095462,
-0.02070337,
0.084591515,
-0.0020777455,
-0.005256662,
0.0417839,
0.015867643,
-0.029633969,
-0.11045389,
-0.023195317,
0.021457689,
0.01918126,
0.0036705714,
0.013436311,
0.007947292,
0.037392683,
-0.0007471633,
0.026387703,
-0.023464717,
-0.034510106,
0.013537336,
-0.015961934,
-0.0066272332,
-0.004374378,
-0.0016652271,
-0.013321817,
-0.021322988,
0.01965271,
0.012857102,
0.014763105,
-0.02869107,
-0.008001172,
-0.013901026,
0.036018744,
-0.03838946,
0.036746122,
0.015665594,
0.012089313,
0.021053588,
-0.018413471,
0.045259155,
0.0023505127,
-0.025566034,
-0.0050344076,
0.00076989393,
-0.018467352,
0.010445975,
-0.013200587,
0.026616693,
0.02011069,
0.004660615,
-0.0006166728,
0.015315374,
-0.00069749274,
-0.015274964,
0.016743192,
0.012897512,
-0.0076913624,
-0.045043636,
-0.024650075,
-0.016244803,
-0.000049091785,
0.0016997439,
-0.008088727,
0.012439532,
0.005492387,
-0.0012476575,
-0.023060616,
0.014022256,
0.0012476575,
-0.0048592975,
-0.019073501,
0.018036311,
-0.020407028,
-0.035210546,
-0.03232797,
0.023909226,
-0.026428113,
-0.02047438,
0.0067821383,
-0.00991391,
0.012796487,
-0.000138804,
-0.014035726,
0.007799122,
-0.022387117,
0.012540557,
-0.007832797,
-0.020595608,
-0.017861202,
0.007085213,
-0.023814935,
0.031681407,
0.0023942902,
0.020986238,
-0.025121525,
0.008378332,
0.0027647146,
-0.003197438,
0.015894584,
0.010870279,
-0.013436311,
0.0009706809,
0.014803515,
0.0137191815,
0.005536164,
-0.00036937228,
0.0058224015,
-0.036826942,
-0.022144657,
-0.056035142,
-0.0011735726,
0.031007908,
0.0044518304,
-0.0056102495,
-0.015477015,
0.020757249,
-0.011698683,
0.0068393857,
-0.0059571015,
0.003131772,
-0.008243632,
-0.0027731333,
-0.005845974,
-0.016473792,
-0.017834261,
0.024879064,
-0.018049782,
0.008041582,
0.02952621,
-0.0016079796,
0.0039702784,
0.01065476,
-0.0063207913,
-0.007011128,
0.0014463398,
-0.018426942,
0.001211457,
-0.0058762818,
-0.023060616,
-0.007751977,
-0.05002753,
-0.027397953,
0.021969547,
-0.009139386,
-0.018197952,
-0.0044316254,
0.01954495,
0.014601465,
0.031681407,
-0.022750806,
-0.03019971,
0.01939678,
0.01891186,
-0.021969547,
0.0125809675,
-0.027371012,
-0.0051792096,
0.011786238,
-0.012574232,
0.033540267,
0.01936984,
0.017066473,
-0.016783603,
-0.014493706,
-0.024367206,
0.0037042461,
0.022831626,
0.0046067354,
-0.015921524,
0.010223719,
0.015490484,
0.016473792,
0.0030879944,
-0.013321817,
-0.014291655,
-0.015019035,
-0.006088434,
0.0027394586,
-0.04633675,
-0.016945243,
0.01993558,
0.027249783,
-0.014197365,
0.00020383878,
0.004596633,
-0.012453002,
-0.017766912,
-0.012560762,
0.007132358,
0.007199708,
0.0017047952,
-0.018507762,
0.018049782,
0.02850249,
0.006058126,
-0.024973355,
0.026886092,
-0.015584774,
0.0050478773,
-0.014520645,
0.0073478776,
0.005670864,
0.016379504,
-0.0054284045,
0.013362226,
-0.0031536606,
0.016487263,
0.005643924,
0.013577746,
0.008277306,
0.00052743417,
0.011974818,
-0.01992211,
-0.005185945,
0.0059907762,
-0.034321524,
-0.03014583,
-0.033028405,
-0.018090192,
0.010378624,
0.018925332,
0.010594144,
0.0025778187,
-0.0007366399,
-0.0030357982,
0.010648024,
-0.016231334,
-0.0028455346,
0.010472914,
0.012473207,
0.016756663,
0.0010388728,
-0.017888142,
0.012432798,
-0.0044855056,
0.013584482,
-0.021376869,
0.00975227,
-0.017766912,
0.055146124,
-0.00910571,
-0.01897921,
-0.009994729,
-0.011840118,
-0.026239533,
0.024946414,
0.032139387,
-0.01889839,
0.09784598,
0.0036975113,
-0.015288435,
-0.025498684,
-0.010028405,
0.010951099,
0.015423134,
0.0055496343,
-0.033567205,
-0.031061789,
0.017861202,
-0.023478186,
0.042187996,
-0.023559006,
-0.013766326,
0.013153441,
-0.0030139093,
0.008614056,
0.002810176,
0.006287116,
0.010796194,
-0.010270865,
0.0069168378,
0.007199708,
-0.032274086,
0.001986823,
0.02047438,
-0.024097806,
0.0097859455,
-0.023222256,
0.022077307,
-0.012614642,
-0.044774234,
-0.0032816255,
-0.0008246157,
-0.008944071,
-0.025040705,
-0.03019971,
0.007132358,
0.016096633,
-0.00013059573,
0.015288435,
-0.014587996,
0.0012080894,
0.0025222548,
-0.010055345,
0.0025205712,
-0.0062500737,
-0.023666766
] |
The enteric nervous system (ENS) autonomously controls gut muscle activity. Mechanosensitive enteric neurons (MEN) initiate reflex activity by responding to mechanical deformation of the gastrointestinal wall. MEN throughout the gut primarily respond to compression or stretch rather than to shear force. Some MEN are multimodal as they respond to compression and stretch. Depending on the region up to 60% of the entire ENS population responds to mechanical stress. MEN fire action potentials after mechanical stimulation of processes or soma although they are more sensitive to process deformation. There are at least two populations of MEN based on their sensitivity to different modalities of mechanical stress and on | [
-0.018613972,
-0.0063741403,
0.013206222,
-0.025806345,
-0.019718418,
0.012775219,
-0.005852222,
-0.020472676,
0.00065113546,
-0.0118862735,
0.0052090837,
0.024217019,
-0.011381191,
0.0046837977,
-0.0063303667,
-0.005599681,
0.029281313,
0.030547386,
-0.011482208,
0.024903933,
-0.009805334,
0.02017636,
0.012135448,
-0.02004167,
0.007192374,
0.010377761,
0.011408129,
-0.032917906,
-0.015691228,
-0.013899869,
0.0028991732,
-0.0067378,
-0.012202792,
-0.020068608,
-0.0030860538,
-0.003690469,
0.018708253,
-0.013845993,
0.0061249663,
-0.0025422482,
0.005986911,
0.008357431,
-0.0038824005,
0.0074213445,
-0.025267592,
-0.007966834,
-0.00044657706,
-0.007441548,
-0.017401773,
0.027314859,
0.024971277,
0.01447903,
-0.030924514,
0.03949071,
-0.013980682,
-0.011973822,
0.012539513,
-0.010458574,
0.025563907,
-0.03687775,
-0.00843151,
0.0023216957,
-0.016714862,
-0.0012601807,
-0.007798473,
-0.0037308757,
-0.0025254122,
-0.0028301454,
0.014896565,
0.00012574448,
0.038601767,
0.02860787,
-0.021334682,
0.009212703,
0.03976009,
-0.017307492,
-0.010876109,
-0.01282236,
0.0011094977,
0.0009512386,
0.006771472,
-0.043612186,
-0.0066064782,
0.021617528,
-0.012431762,
-0.02885031,
0.00563672,
-0.0025321466,
-0.007704191,
-0.015139004,
-0.000029463143,
0.014802283,
0.016943833,
0.0052057165,
0.007892755,
0.0181695,
-0.014061496,
-0.0061721075,
-0.008788435,
0.0023806219,
-0.013637226,
-0.0060475203,
0.00042132294,
-0.015448788,
-0.016930364,
0.0025287794,
0.007434814,
-0.012566451,
0.0054346872,
-0.012552982,
-0.0110242665,
0.004454827,
-0.015314099,
-0.02398805,
0.0062057795,
0.011899742,
0.04318118,
0.004946441,
-0.0070576854,
-0.008956796,
0.0005513817,
0.008579667,
0.020014733,
-0.004175348,
0.04261549,
0.017873185,
-0.013718039,
0.0041787154,
-0.021886906,
-0.0106269345,
-0.02515984,
-0.010788561,
0.018048279,
0.02801524,
-0.012357684,
0.017846247,
-0.007643581,
0.009010671,
-0.021563653,
-0.021819562,
0.017900122,
0.020755522,
-0.028311554,
-0.0013351013,
-0.020513082,
0.01627039,
0.01779237,
0.028096052,
0.012714609,
-0.0034648655,
0.010256541,
-0.020311048,
0.0012256667,
-0.019678012,
-0.018129092,
0.017509526,
0.01329377,
0.017361367,
0.010424902,
-0.03835933,
-0.0039497446,
-0.030709013,
0.012344215,
-0.017738495,
-0.0034008885,
0.03014332,
0.006040786,
-0.011280174,
0.011327316,
-0.0065795407,
-0.016526297,
0.032028962,
-0.00706442,
-0.0007458384,
-0.020849803,
0.025079027,
-0.007145233,
0.005027254,
-0.02113265,
-0.010202666,
-0.017455649,
0.00504409,
0.023018291,
-0.00013532,
0.023476232,
0.009993898,
0.025456155,
0.00465686,
0.0009546058,
-0.03585412,
-0.005980176,
-0.0023099105,
-0.024432521,
-0.004235958,
-0.63443744,
-0.0068085114,
0.02278932,
-0.015354507,
0.006212514,
0.024661493,
-0.006256288,
-0.010404699,
0.004767978,
0.0129031725,
-0.013590085,
0.019260477,
0.009791865,
-0.013516006,
0.0013005873,
-0.018358063,
0.0013468865,
-0.004400952,
0.025617782,
-0.0016718229,
-0.025375342,
-0.009623504,
-0.0019917085,
0.0175634,
0.008088053,
-0.008020709,
-0.0014899932,
-0.0018233476,
-0.020984491,
0.019435573,
-0.027745862,
0.034965172,
0.0061114975,
0.015556539,
0.045632515,
-0.005562641,
-0.02315298,
0.029981693,
-0.0060980287,
0.050885372,
-0.021563653,
-0.0048319553,
0.014842689,
-0.012095041,
-0.010175727,
0.021119181,
0.020876741,
-0.011421598,
0.0023132777,
-0.020095548,
0.02359745,
-0.0016330999,
-0.00907128,
0.023126042,
0.02373214,
0.012438497,
0.032917906,
0.009219438,
-0.021334682,
0.006852285,
0.01697077,
0.019664543,
-0.017280554,
-0.021550184,
0.0016920262,
0.0034918033,
-0.023651328,
-0.014802283,
0.0020742053,
-0.0022105775,
0.015408382,
0.015112067,
-0.005933035,
-0.0006178842,
0.018250313,
0.042992618,
-0.0061418023,
0.029146625,
-0.010249807,
0.013044596,
-0.018088685,
0.010822233,
-0.03038576,
-0.01472147,
0.03178652,
-0.017590338,
-0.0074954233,
0.0045726798,
-0.009623504,
-0.009259845,
-0.00492287,
0.0036163903,
-0.009535956,
-0.030816764,
-0.0013755079,
0.014546375,
-0.01912579,
0.02528106,
0.043369748,
-0.031247767,
-0.0057983464,
-0.019651074,
0.019327821,
-0.00103121,
0.016189575,
-0.00433024,
-0.03976009,
0.022870133,
0.031247767,
-0.015718166,
0.0047578765,
-0.005444789,
-0.016472422,
0.008545995,
-0.011630365,
-0.030278008,
0.021792624,
0.025900628,
-0.009535956,
-0.019731887,
0.012492373,
-0.011145486,
0.00670076,
-0.01683608,
0.01864091,
0.0067310655,
0.0023301137,
-0.004060863,
0.0009689165,
-0.017940529,
-0.0042595286,
0.006212514,
0.032675467,
-0.009657176,
0.0012694405,
0.02680304,
0.025240654,
-0.007912958,
0.007582971,
-0.03407623,
-0.034372546,
-0.017388305,
-0.0024648022,
-0.029577628,
0.0064246487,
-0.017132396,
-0.014425155,
-0.006215881,
0.0072731874,
-0.0038689314,
0.009475347,
-0.0024008253,
-0.022264034,
-0.0005122378,
0.036500625,
-0.005522235,
-0.022062002,
-0.010997328,
-0.011913211,
-0.021698343,
0.0013948693,
0.011994025,
-0.015381444,
0.015947137,
-0.040029466,
-0.022290971,
0.0032813523,
0.005656923,
0.0020977757,
-0.042911805,
0.014209652,
0.0052090837,
-0.003505272,
0.017900122,
-0.0009360861,
0.002444599,
-0.017751964,
-0.017159333,
-0.0121623855,
0.015947137,
-0.008950061,
-0.038709518,
-0.006222616,
-0.018290719,
0.056784734,
0.0037544463,
0.018479284,
-0.0010716165,
-0.01779237,
0.011502411,
-0.005838753,
0.000100174686,
-0.025806345,
0.009354127,
-0.024365177,
-0.01839847,
0.018775597,
0.008323759,
-0.0038352595,
0.014788814,
0.0025893894,
-0.031382456,
0.004407686,
-0.015125535,
0.031301644,
-0.013805587,
-0.0011010797,
-0.017240148,
0.02645285,
0.0024462827,
-0.0062057795,
-0.015798979,
-0.0028065748,
-0.016297327,
-0.006741167,
0.0012938528,
-0.015125535,
0.0035221083,
-0.010357558,
0.0031938048,
-0.0058959955,
-0.020324517,
0.0058017136,
0.028203804,
-0.011953617,
0.054656655,
0.00029105376,
0.027611174,
-0.025981441,
-0.033079535,
0.011549552,
0.038628705,
0.0017543196,
0.01186607,
-0.00083043973,
0.017603807,
0.0027695354,
0.019206602,
0.0062360847,
0.012182589,
0.016418546,
0.0065189307,
-0.0050104177,
-0.0034817017,
0.0336991,
-0.012795422,
0.00831029,
-0.019044975,
-0.00741461,
0.009562895,
0.0068118786,
0.005259592,
-0.029577628,
-0.019610668,
-0.005151841,
-0.0048959325,
0.00794663,
-0.0056468216,
0.03418398,
0.023193385,
0.020216767,
-0.0032678833,
0.01294358,
-0.011603427,
0.02137509,
-0.004949808,
-0.005848855,
0.017428711,
-0.012337481,
-0.0049262373,
-0.00843151,
0.016108762,
0.0026718862,
-0.016566705,
0.035692494,
0.005633353,
0.037928324,
-0.001946251,
0.018762128,
0.023516638,
-0.0032628325,
-0.038709518,
0.01139466,
0.015273693,
0.0031382455,
0.017199742,
-0.024176612,
0.012963783,
-0.006976872,
-0.007993772,
-0.011448535,
0.0212404,
-0.0025287794,
0.0050373557,
-0.013771915,
0.02458068,
-0.0036635313,
-0.019556792,
0.035827182,
-0.012957049,
0.014021088,
-0.009906351,
-0.026089191,
-0.025658188,
0.014492499,
0.03765895,
-0.0204188,
-0.03367216,
0.0014588465,
-0.018331125,
0.022654632,
0.0011423281,
0.00048319553,
-0.008276618,
-0.0014310669,
0.008411306,
0.0015741736,
-0.019731887,
0.053740773,
-0.0061721075,
-0.022870133,
-0.05947851,
-0.0035120065,
0.0027038746,
0.028149929,
0.0036803675,
-0.009306986,
0.017361367,
-0.010081446,
-0.0079601,
-0.011441801,
-0.021119181,
0.019960858,
-0.008788435,
-0.008135195,
-0.00255235,
0.00086958363,
0.006626682,
0.040298846,
-0.006428016,
0.00818907,
-0.042238362,
-0.01400762,
-0.011031001,
0.018950693,
0.025361873,
0.042211425,
0.04547089,
-0.00053580827,
-0.0071384986,
-0.018075217,
0.027745862,
0.012263401,
-0.032890968,
0.020216767,
0.005579477,
-0.011650569,
-0.0052057165,
-0.01803481,
-0.01721321,
0.007259718,
0.017644214,
0.0017391673,
-0.014465561,
0.01662058,
0.018236844,
-0.0019917085,
-0.0016608795,
0.011239768,
-0.026789572,
0.015017785,
0.024190081,
-0.012600123,
-0.018587034,
-0.005562641,
-0.01864091,
0.006303429,
-0.019556792,
0.010067977,
0.0051653096,
-0.0008388578,
-0.0051047,
-0.0016920262,
-0.03596187,
-0.0051922477,
-0.001052255,
0.006273124,
-0.02028411,
-0.01139466,
-0.022573818,
0.0028385634,
0.007912958,
-0.030197196,
0.014330872,
-0.012930111,
-0.02658754,
-0.018209906,
0.005838753,
0.017482586,
0.0068085114,
0.028904185,
-0.021577122,
-0.009246376,
0.03143633,
0.017940529,
-0.020028202,
-0.005933035,
-0.020109016,
0.020984491,
0.030412698,
0.018452344,
0.0094214715,
-0.0025809712,
-0.023610922,
0.012674202,
-0.033914603,
0.023301138,
-0.0023149613,
-0.0011313846,
0.011657303,
0.00841804,
0.024621086,
0.018209906,
-0.010364292,
-0.0005332829,
-0.032082837,
-0.012297074,
-0.0069364654,
0.008512323,
-0.014802283,
0.005559274,
0.023583982,
0.0060778256,
-0.012128714,
0.012620327,
0.0073135938,
0.0082833525,
-0.0023267465,
-0.011266706,
0.035180677,
0.00024391273,
0.01627039,
0.003862197,
-0.006542501,
-0.0025658188,
-0.012977252,
0.03927521,
0.0091925,
-0.029173562,
0.02005514,
-0.001757687,
0.020944085,
-0.03000863,
-0.0025489826,
-0.008505588,
0.043746874,
0.0013426775,
-0.048649542,
-0.007569502,
-0.00070753635,
-0.038170762,
0.031193892,
-0.024419053,
-0.009886147,
-0.0028133092,
0.0069027934,
-0.012963783,
-0.015394913,
0.0426963,
-0.027516892,
0.0037039379,
0.021159587,
-0.016458953,
0.021199994,
0.0028301454,
0.0074617513,
0.004310037,
0.008849044,
-0.016634049,
-0.042022858,
-0.020728584,
-0.022641163,
0.026547134,
0.022950945,
0.03644675,
-0.0023469497,
0.017361367,
0.027880551,
-0.0050474573,
0.006431383,
-0.0117313815,
-0.0038049545,
-0.02563125,
0.033914603,
0.015960606,
0.012896438,
0.017428711,
-0.009899616,
0.00048698366,
0.02099796,
0.008330493,
-0.019570261,
-0.018694784,
-0.048218537,
0.027005075,
0.017280554,
0.0015152473,
0.036015745,
-0.045443952,
-0.021886906,
0.019866576,
0.01216912,
-0.012485638,
-0.009589832,
0.0048992997,
-0.011105079,
0.016903426,
-0.012741546,
0.028634807,
0.0019715051,
-0.009940023,
-0.016418546,
-0.015206349,
-0.0014319087,
-0.012014228,
0.010492246,
0.013017658,
-0.006027317,
-0.019610668,
-0.0014024456,
-0.016472422,
-0.017105458,
-0.034722734,
-0.000082602026,
-0.017307492,
-0.0055693756,
-0.006353937,
-0.028149929,
0.003922807,
0.012802157,
-0.017953997,
0.03345666,
-0.03194815,
-0.008943327,
0.006508829,
0.0061519044,
0.028338492,
-0.0151794115,
0.021765687,
0.008519057,
-0.011569755,
0.0016272073,
-0.0027274452,
0.002269504,
-0.009152094,
0.048110787,
-0.02588716,
0.009488815,
-0.037066318,
0.013529475,
0.003488436,
-0.016256921,
-0.028392367,
0.026183475,
0.01744218,
-0.0054414216,
-0.020566957,
-0.0039093383,
0.0014588465,
0.013819056,
-0.008168867,
-0.009381064,
-0.021523247,
0.022654632,
-0.024742305,
0.0410531,
-0.016822612,
0.006057622,
0.003660164,
-0.007966834,
-0.0057276348,
-0.0045524766,
-0.010222869,
0.007239515,
0.0038790333,
0.013967213,
-0.0032493637,
0.020944085,
0.014532906,
0.025267592,
0.009327189,
-0.007582971,
-0.019422103,
0.033914603,
-0.012761749,
-0.019664543,
0.01733443,
-0.025941035,
0.04199592,
-0.009064546,
0.0038419939,
-0.009542691,
-0.012068103,
-0.009940023,
0.020391861,
0.028338492,
-0.017738495,
0.001482417,
-0.024486396,
-0.013980682,
-0.02588716,
-0.005353874,
0.00065281906,
-0.021213463,
-0.012108509,
-0.0033318605,
0.0008258098,
0.012081572,
0.021119181,
0.00712503,
-0.018129092,
0.040918414,
0.004313404,
0.018492753,
-0.011845867,
0.003579351,
-0.019300884,
0.019018037,
-0.0037106723,
-0.034722734,
0.0077715353,
-0.00824968,
-0.015570008,
0.00025233076,
-0.0023014923,
0.015044723,
-0.007300125,
-0.0034985377,
-0.001250079,
0.014667594,
0.009468612,
-0.016472422,
0.0052225525,
-0.0028436142,
-0.008047647,
-0.021402027,
0.003562515,
-0.016176106,
-0.0120074935,
-0.014559844,
-0.018209906,
0.003458131,
0.002281289,
-0.016539767,
-0.019449042,
-0.0053740772,
0.011603427,
-0.011179158,
-0.009226172,
0.0061148647,
-0.012034431,
0.02825768,
0.03356441,
-0.016903426,
-0.008795169,
0.017361367,
0.02278932,
0.0050306213,
-0.0120411655,
0.006522298,
0.0031820193,
-0.017361367,
-0.04011028,
-0.01352274,
-0.012653999,
0.046144333,
0.01425006,
0.016997708,
-0.003717407,
0.022519942,
-0.047679782,
-0.026425913,
-0.006067724,
0.009152094,
0.019624136,
0.022600755,
-0.010222869,
-0.011253237,
-0.02089021,
0.002405876,
-0.0074482826,
0.009697583,
0.02660101,
-0.010492246,
-0.0010977125,
0.0072327806,
-0.026870387,
-0.022533411,
0.020351455,
-0.020028202,
-0.003488436,
0.012552982,
-0.003269567,
0.01994739,
0.021307744,
0.003613023,
0.0020691545,
0.004151778,
0.04436644,
-0.028419305,
-0.0022610857,
-0.0049531753,
-0.0063269995,
-0.013260098,
-0.005384179,
0.01803481,
0.0005631669,
0.0071384986,
-0.010929984,
-0.012593389,
0.009825537,
-0.023274198,
0.032325275,
0.020311048,
-0.01359682,
0.013441928,
0.000094492505,
-0.01080203,
-0.045228448,
-0.010855906,
-0.024257427,
0.009744724,
0.0009318771,
-0.022479536,
-0.014708001,
-0.00140918,
0.013664164,
-0.022317909,
0.008774966,
-0.012377887,
0.006566072,
-0.011381191,
0.005889261,
0.0027190272,
0.0016533032,
-0.022156283,
0.008519057,
-0.02005514,
-0.010418167,
-0.02682998,
-0.00057032227,
-0.01566429,
0.01897763,
0.019368228,
-0.008155398,
0.0019563527,
0.0049700113,
-0.00035713537,
-0.017253617,
0.014384748,
0.18393083,
-0.008135195,
-0.008889451,
-0.0027813206,
-0.012229729,
-0.006475157,
0.011179158,
0.01039123,
-0.010007367,
0.00700381,
-0.0038285248,
0.00048193283,
-0.0068421834,
0.0038184233,
0.02645285,
-0.01839847,
-0.029119687,
0.00055306527,
0.008909654,
-0.0054111164,
0.012997455,
-0.011401394,
-0.019058444,
-0.008505588,
0.031732645,
0.00046846396,
-0.037578136,
-0.0023772547,
0.021388559,
0.030520448,
-0.017038114,
0.012795422,
0.008626808,
-0.0018536525,
0.007609909,
-0.0010514132,
0.0011010797,
0.01744218,
-0.0026920894,
0.003996886,
0.020445738,
-0.0031466635,
-0.009596567,
0.014317404,
-0.010424902,
0.0027914224,
-0.005741104,
-0.005522235,
-0.019839639,
0.013899869,
-0.036258183,
0.012229729,
0.014573312,
0.03025107,
0.012175854,
-0.0071991086,
0.0057512056,
0.008680684,
0.024257427,
0.031247767,
-0.018358063,
0.008485385,
-0.030304946,
0.033429723,
-0.014021088,
0.025496561,
-0.0047747125,
-0.0010674075,
0.004037292,
-0.008081319,
-0.036042683,
-0.016687924,
-0.013603554,
-0.01282236,
-0.019139258,
0.003815056,
0.025739001,
0.006697393,
0.0095763635,
0.0075088926,
0.0031870701,
0.0043773814,
-0.009717787,
-0.0013915021,
-0.006118232,
-0.019772295,
0.021213463,
0.011556286,
-0.016903426,
-0.014074964,
0.007926427,
0.0047814474,
-0.0017324327,
-0.025348404,
0.0019748723,
-0.0123172775,
-0.0013670898,
-0.0030254438,
-0.020257173,
-0.00040364504,
-0.038170762,
0.07892755,
-0.00896353,
0.013980682,
0.000012791476,
-0.00034787552,
-0.011118548,
0.004889198,
-0.004235958,
0.0009546058,
-0.00943494,
0.0066704554,
0.005794979,
-0.021509778,
-0.01412884,
0.010155524,
0.01744218,
-0.014573312,
0.020459207,
-0.023947643,
-0.005495297,
0.0028200436,
-0.002973252,
0.0073876726,
-0.008155398,
-0.0089029195,
-0.010478777,
-0.0022644529,
0.02493087,
-0.01721321,
-0.011300378,
-0.034722734,
0.008586401,
0.0031045733,
0.011953617,
-0.00039164934,
0.0064010783,
-0.0018974264,
0.00069701375,
0.03515374,
0.0017896754,
-0.0020203297,
0.025981441,
0.0121623855,
0.016607111,
-0.016674455,
0.03356441,
0.040164158,
-0.031544082,
-0.021523247,
-0.0012829094,
-0.010808764,
0.006990341,
0.010404699,
0.033806853,
-0.018007873,
-0.038413204,
-0.036123496,
0.0028823372,
0.008027444,
-0.030278008,
-0.005754573,
0.021294275,
-0.023314606,
-0.006835449,
0.011475473,
-0.1701387,
0.020863272,
0.024499865,
-0.029469877,
0.023718672,
0.013125409,
-0.0064785243,
0.031247767,
-0.010229603,
0.015260224,
0.024526803,
-0.007441548,
-0.019085381,
-0.043935437,
-0.002134815,
0.032082837,
-0.0033066063,
-0.0052663265,
-0.010977125,
0.016068356,
0.003717407,
-0.028984997,
-0.004791549,
-0.022021595,
-0.012856032,
0.024701899,
0.0071384986,
0.030870639,
-0.0107144825,
-0.028149929,
0.008404572,
0.00041458852,
0.022600755,
-0.0018368165,
0.025321467,
-0.0008396996,
-0.010000632,
-0.025025152,
-0.011832398,
0.021792624,
0.013913338,
0.011051204,
-0.012202792,
0.022210158,
-0.0029160094,
-0.010236338,
0.01086264,
-0.016553236,
0.010775092,
-0.032890968,
-0.013266833,
-0.010889578,
0.022964416,
0.018896818,
0.040756784,
0.013967213,
-0.002134815,
0.005498664,
0.012155651,
-0.010229603,
0.0105595905,
-0.0047982833,
0.04215755,
0.015650822,
-0.012411559,
-0.021280807,
-0.011825664,
0.00018214536,
-0.035450052,
0.030358823,
-0.012081572,
-0.014223122,
0.006771472,
-0.0539024,
0.032459967,
-0.0045053354,
0.004013722,
-0.017455649,
-0.023759078,
0.003347013,
-0.01400762,
0.014425155,
-0.02646632,
-0.038116887,
-0.010256541,
0.005623251,
0.01370457,
0.008323759,
0.029847005,
0.01472147,
0.00806785,
-0.022412192,
0.00391944,
-0.023328075,
0.012014228,
-0.009482081,
0.007010544,
-0.0029580996,
-0.005714166,
-0.0010884526,
0.010303682,
-0.011690975,
-0.029146625,
0.039356023,
-0.00050003163,
-0.0063842423,
-0.029065812,
-0.014681063,
0.0033251261,
-0.019516386,
-0.0117650535,
-0.0020944085,
0.010458574,
0.052043695,
-0.017038114,
0.0479761,
0.007643581,
-0.009805334,
0.0068051443,
0.0018620706,
0.029254375,
0.009185766,
-0.0029833536,
-0.00004088011,
0.010182462,
-0.055814978,
-0.13447315,
-0.013623757,
0.00064776826,
0.030331884,
0.016203044,
0.028769497,
0.0036029215,
0.028122991,
-0.0123172775,
0.02398805,
-0.015556539,
-0.013307239,
0.015866322,
-0.015502664,
0.012451966,
-0.019502917,
0.011293643,
-0.012795422,
-0.012936845,
0.03844014,
-0.024944339,
-0.006394344,
-0.016916895,
-0.0068455506,
-0.010236338,
0.036473688,
-0.019287415,
0.01733443,
0.0028335126,
-0.020391861,
0.025792876,
-0.008997202,
0.026883855,
-0.012411559,
-0.013724773,
-0.0048622605,
-0.0136439605,
-0.019920452,
0.029119687,
0.008094788,
0.0078186765,
0.023004822,
0.030951452,
-0.00055643247,
0.0121960575,
-0.021550184,
-0.018304188,
0.021509778,
-0.0027442812,
-0.025011683,
-0.0072462494,
-0.012963783,
-0.023893766,
0.00747522,
0.017832778,
0.023651328,
0.0037039379,
0.0041450434,
-0.0076503153,
0.00907128,
0.009623504,
0.00046004594,
-0.01014879,
0.0028217272,
0.021078775,
-0.000064292784,
-0.036231246,
-0.015408382,
0.016997708,
-0.011643834,
0.009906351,
0.0050642933,
-0.004054128,
0.0052629593,
-0.036231246,
0.0002247617,
-0.008559464,
-0.0065627047,
-0.0039497446,
0.0065761735,
-0.0057040644,
-0.021779155,
0.0022476169,
-0.0029277946,
-0.003244313,
-0.0036029215,
-0.004464929,
-0.0059060976,
0.010263275,
-0.020755522,
-0.010552856,
0.01425006,
0.0263451,
0.008734559,
-0.0036332265,
0.009441675,
-0.0057276348,
-0.016122231,
-0.00059641816,
-0.009212703,
-0.023786016,
-0.01803481,
-0.029712318,
0.0057074316,
0.003291454,
-0.0071384986,
0.008343962,
0.003956479,
0.026722228,
-0.008512323,
0.022977885,
0.016903426,
-0.01649936,
0.027422609,
0.015300631,
-0.016189575,
-0.047787532,
-0.013994151,
0.025604313,
-0.004468296,
0.012781953,
0.014074964,
-0.023328075,
0.0018283984,
-0.004576047,
0.029469877,
-0.017065052,
0.015085129,
-0.03846708,
-0.0039665806,
-0.021065306,
-0.0101959305,
-0.010512449,
-0.035099864,
-0.02930825,
0.008835576,
-0.014869628,
-0.008135195,
0.0047410405,
0.02398805,
0.007785004,
0.02064777,
-0.029281313,
-0.04046047,
-0.012552982,
-0.010546122,
0.009111688,
0.0017155966,
-0.0277728,
0.014708001,
-0.010418167,
-0.0011877855,
0.035207614,
0.009630239,
0.0026483156,
-0.008397837,
-0.0141961835,
-0.004623188,
0.0006031526,
-0.0067647374,
-0.009697583,
-0.01264053,
0.029011935,
0.016701393,
0.010761623,
-0.006367406,
-0.023341544,
-0.0074954233,
-0.019193133,
0.0007870868,
0.017725026,
-0.027826676,
-0.0010951872,
-0.012950314,
0.024755774,
0.001782941,
0.009596567,
0.003582718,
-0.017482586,
-0.014155777,
-0.0212404,
0.028419305,
-0.0044312566,
-0.007320328,
-0.015098598,
0.025739001,
0.024728836,
0.025523499,
-0.02076899,
0.0018334492,
0.012175854,
-0.0027425976,
-0.0069229966,
0.009340658,
0.0017560032,
-0.0026870386,
0.019610668,
0.024674961,
-0.003936276,
0.008916389,
0.025429217,
0.018358063,
0.01909885,
0.015502664,
-0.0060340515,
-0.039329085,
0.03264853,
0.006646885,
-0.053821586,
-0.026506728,
-0.025739001,
-0.0024765877,
-0.000103121,
0.010276744,
-0.015637353,
-0.001013532,
0.00759644,
0.022452598,
-0.015731635,
-0.017590338,
-0.008269884,
0.015448788,
0.028473182,
0.011354254,
0.00070879905,
-0.005808448,
0.003158449,
0.0116101615,
0.032136712,
-0.005821917,
0.01648589,
0.011199362,
0.018856412,
0.010283479,
-0.04000253,
-0.019179665,
-0.017267086,
-0.017644214,
-0.0065795407,
0.0013679316,
-0.015852854,
0.08975652,
0.008276618,
0.0133341765,
0.014815751,
0.012034431,
0.012027697,
-0.017657682,
0.0082833525,
-0.010061243,
0.00896353,
0.014182715,
-0.0037914854,
0.010404699,
-0.029281313,
-0.003613023,
0.037012443,
-0.010781826,
0.026250819,
0.009946757,
-0.018209906,
0.022223627,
-0.03157102,
0.0053774444,
-0.0015127219,
-0.020109016,
0.017603807,
0.043854624,
0.010041039,
0.0020203297,
-0.013845993,
-0.0022644529,
0.014263528,
-0.044716634,
0.011690975,
-0.015772041,
-0.009859209,
-0.013967213,
-0.0322714,
0.0010253174,
0.031894274,
-0.0062663895,
0.031597957,
0.0075897058,
-0.0061889435,
0.00477808,
-0.0051653096,
-0.017778901,
0.013664164,
-0.024782712
] |
The centromeric histone H3 variant (CenH3) is essential for chromosome segregation in eukaryotes. We identify posttranslational modifications of Saccharomyces cerevisiae CenH3, Cse4. Functional characterization of cse4 phosphorylation mutants shows growth and chromosome segregation defects when combined with kinetochore mutants okp1 and ame1. Using a phosphoserine-specific antibody, we show that the association of phosphorylated Cse4 with centromeres increases in response to defective microtubule attachment or reduced cohesion. We determine that evolutionarily conserved Ipl1 | [
-0.0039768782,
-0.0015536787,
-0.0020204564,
-0.021623433,
-0.03405286,
0.029280607,
-0.0002677231,
-0.008991789,
-0.0031562257,
-0.01244291,
0.021138119,
0.005163201,
0.005075575,
0.009652355,
-0.017835287,
-0.0006508768,
0.019439518,
-0.026786633,
-0.007535847,
-0.00073302625,
-0.03186895,
-0.0072999303,
0.004236386,
-0.03017035,
0.0024484762,
0.01787573,
0.0065685892,
-0.0271641,
0.0054833735,
-0.011141999,
0.0031023019,
0.00915356,
0.005328343,
-0.003245537,
-0.030062502,
-0.020356223,
0.0029540116,
0.00017672674,
0.026193472,
-0.0119036725,
-0.0044284896,
0.014909922,
-0.0133798355,
-0.0032404815,
-0.0014256097,
0.0037780341,
0.007252747,
-0.02460272,
-0.015125617,
0.02018097,
0.02617999,
0.040550675,
-0.0016143429,
0.013966257,
-0.032947425,
-0.02216267,
0.008910903,
0.007407778,
-0.0032017238,
-0.011566649,
0.002362535,
-0.0077380612,
-0.026355242,
0.027716817,
0.006551738,
-0.0009495639,
0.007347114,
-0.015678337,
-0.0078324275,
-0.006696658,
0.05265656,
0.01817231,
-0.01617713,
-0.014842518,
0.018630663,
-0.028013399,
-0.026665304,
-0.013150659,
-0.0033870868,
0.011526206,
0.030359082,
-0.02129989,
0.013777523,
0.018374525,
0.016258016,
0.019951794,
0.011067854,
0.016648965,
0.0060731648,
-0.0015225039,
0.03575146,
0.015610931,
0.020855019,
0.018536296,
-0.02101679,
0.004273459,
0.014208914,
0.021987418,
0.009160301,
-0.0039094733,
-0.023079373,
0.010973487,
-0.00074903487,
-0.026624862,
-0.029199721,
-0.009396217,
0.022283997,
-0.009207483,
0.014896441,
0.003447751,
-0.0045666695,
0.02987377,
-0.014923403,
-0.03580538,
0.021245966,
-0.019250786,
0.010751052,
0.003922954,
-0.013271988,
-0.0026978736,
0.027501123,
0.043165978,
0.009423179,
-0.02572164,
0.028067322,
0.017889211,
-0.0130091095,
-0.017633073,
-0.008048123,
-0.030817434,
0.021380775,
0.015219985,
0.024993667,
-0.009921974,
-0.03186895,
0.008412108,
-0.02189305,
-0.018684587,
-0.028633522,
-0.0543282,
0.007778504,
0.022513174,
-0.009921974,
0.01143858,
0.021502104,
0.010852159,
0.00026898694,
0.014680747,
-0.020531476,
0.0094299195,
0.005931615,
0.02216267,
0.018954206,
0.015813146,
0.008405368,
0.016231054,
-0.005908023,
0.01501777,
-0.0023372585,
-0.037423097,
-0.018428449,
-0.0065719597,
-0.0049643572,
-0.004873361,
0.023996077,
0.036506392,
0.0028293128,
-0.0075425874,
-0.0007650435,
-0.0042296457,
0.001673322,
0.003432585,
-0.029631112,
0.011270068,
-0.025667714,
0.008061604,
0.011115037,
0.014505494,
-0.02817517,
-0.022944564,
-0.005688958,
0.02844479,
0.01845541,
0.0091940025,
-0.02045059,
0.009416439,
0.018266678,
-0.009099636,
-0.00011679973,
-0.018145349,
-0.011479023,
-0.01028596,
-0.0059855385,
-0.027433718,
-0.61731935,
-0.019318191,
-0.0025040852,
-0.010245516,
-0.00929511,
0.04216839,
0.028471751,
0.012490094,
-0.02960415,
0.0045262263,
-0.0047385516,
0.029388456,
-0.008021161,
-0.004448711,
-0.039094735,
-0.036856897,
-0.0031713918,
-0.015988398,
0.026557457,
-0.0029860288,
-0.03246211,
-0.005776584,
0.0114048775,
0.010373585,
0.01101393,
0.011998039,
0.050122146,
-0.026854038,
-0.0122743985,
0.029792883,
-0.022823235,
0.015368274,
-0.023402916,
0.019722618,
0.049421135,
0.01244965,
0.00048278627,
0.014667266,
0.01902161,
0.050149105,
0.004206054,
-0.010023081,
0.015570489,
0.013292209,
-0.011512725,
0.02159647,
-0.008095306,
-0.014748151,
-0.00053586747,
-0.024076963,
-0.014411128,
-0.032111604,
0.00015071273,
0.024360063,
-0.012773193,
-0.002601822,
0.016824216,
-0.016824216,
0.016123207,
0.017821806,
-0.015988398,
0.028121246,
-0.003302831,
-0.023780383,
-0.010056783,
0.0043273824,
-0.020828057,
-0.014087585,
0.025505943,
0.0067573227,
0.0070437924,
0.022904122,
-0.005591221,
0.00041264322,
-0.008641284,
0.019358633,
0.0014694227,
-0.002286705,
-0.007252747,
0.005934985,
-0.0046947384,
-0.010380326,
-0.022378365,
-0.0038926222,
0.013211324,
-0.0013480943,
-0.03033212,
0.025627272,
-0.009113117,
-0.01644675,
0.002689448,
-0.00207438,
0.0026372094,
-0.0125170555,
-0.035427917,
0.018698068,
0.010966747,
0.0012351914,
-0.012287879,
-0.021542545,
-0.014613342,
-0.011088075,
-0.011081335,
-0.0055137053,
0.014060623,
0.021933494,
-0.01415499,
0.012719269,
0.04402876,
-0.012092406,
0.00037999408,
-0.011505985,
-0.01774092,
-0.024683606,
0.0043004206,
-0.023955636,
0.015557008,
0.036398545,
-0.0032371113,
-0.020666284,
0.0075897705,
0.011930634,
0.015826626,
-0.00643378,
0.028256055,
0.008621063,
-0.0019378855,
-0.006325932,
-0.012139589,
-0.008762613,
0.018118387,
-0.0032927203,
0.035427917,
-0.01872503,
0.022405326,
0.018185792,
0.0033971975,
0.00012490936,
0.007711099,
-0.02388823,
-0.01890028,
-0.0034983046,
-0.01358879,
0.0008880571,
-0.007987458,
-0.01646023,
-0.031194901,
-0.001407916,
0.008964827,
0.0005164886,
0.021272928,
0.018698068,
-0.017713958,
-0.0017997058,
-0.005503595,
-0.0050216513,
-0.019331671,
-0.024656644,
-0.01585359,
-0.02573512,
0.01617713,
0.005874321,
-0.012786674,
-0.0038049961,
-0.0058911717,
-0.020517996,
0.0073538544,
-0.0034679724,
-0.024508353,
-0.014613342,
-0.0012115997,
0.0041622412,
-0.0497986,
0.0044419705,
0.0017508374,
0.028202131,
0.015152579,
-0.0040004696,
-0.019857429,
0.0021620062,
0.0010414028,
-0.02704277,
-0.024575759,
-0.0091940025,
0.03130275,
0.01817231,
0.029711997,
0.00010963798,
0.026624862,
0.02746068,
0.0036364843,
0.004664406,
-0.00500143,
0.013514645,
0.018050982,
-0.010326402,
0.022391846,
0.005931615,
-0.0013379835,
0.025546387,
0.021906532,
-0.0047183298,
-0.008122268,
-0.036155887,
0.019250786,
-0.023402916,
-0.0038083664,
-0.016891621,
-0.0050250213,
0.010016341,
-0.007751542,
-0.0018182421,
-0.013393316,
0.00009757886,
0.00036187907,
0.0049643572,
-0.002158636,
-0.017660035,
-0.00019389387,
-0.00024097184,
-0.0021283037,
-0.007973977,
0.029010989,
0.010939785,
0.0016354069,
0.0135079045,
0.010272479,
0.026301319,
-0.0022715388,
0.030952245,
-0.03691082,
0.033217043,
-0.014896441,
0.021124637,
0.010710609,
0.028498713,
0.044648882,
0.001801391,
0.05721312,
-0.01702643,
-0.0056249234,
0.030979207,
-0.012496834,
-0.030116426,
-0.008041382,
-0.000865308,
0.019048572,
0.01873851,
0.0009554618,
0.018630663,
-0.0006496129,
0.0067135096,
-0.027298909,
0.005877691,
0.009706278,
0.009814126,
0.004175722,
0.0024518464,
0.028013399,
0.014707709,
-0.011249847,
-0.025694676,
-0.0044824136,
-0.0029068282,
-0.0105420975,
0.021245966,
0.010825197,
-0.006079905,
-0.022715388,
-0.0048598796,
-0.01672985,
0.012193512,
0.00033260015,
-0.0077717635,
-0.009679317,
-0.000034808214,
0.000268355,
0.0055271867,
0.028229093,
0.002760223,
-0.018091425,
-0.037692714,
0.016568078,
0.018388005,
-0.007711099,
0.000082886734,
-0.028013399,
0.0075965114,
-0.001558734,
0.020679766,
0.0019665326,
0.009834347,
-0.016190613,
0.002918624,
-0.011553168,
-0.0082031535,
0.024953226,
-0.015786184,
0.024184812,
0.008162711,
-0.010993709,
0.010562318,
-0.024467912,
-0.011634054,
0.020935904,
0.0076099923,
0.0054530413,
-0.02373994,
-0.015098656,
-0.019035092,
0.020261858,
-0.024238735,
0.009092896,
-0.014977328,
-0.015799664,
-0.00815597,
0.008378406,
0.01072409,
0.039930552,
-0.01172842,
-0.018414967,
-0.0017407268,
0.0037712937,
-0.011681236,
0.022203112,
0.04402876,
-0.0073201517,
0.008924384,
0.014411128,
0.014653784,
-0.010616242,
-0.010353364,
0.016473712,
-0.015557008,
-0.0101713715,
-0.011923893,
0.023106337,
0.008621063,
-0.00443523,
0.024211774,
0.008755872,
-0.020046161,
0.0053822664,
0.017970096,
0.018617181,
-0.012827117,
0.012779933,
0.048935823,
0.02560031,
0.0007831585,
0.009874791,
0.038258914,
0.010629723,
0.0019412558,
-0.013642714,
-0.006130459,
-0.0091872625,
0.0059147635,
-0.005894542,
-0.032219455,
0.001058254,
0.008385146,
-0.003831958,
0.008641284,
0.008674987,
-0.0044756727,
0.010279219,
0.019843947,
-0.010036562,
-0.009335552,
0.026112586,
0.014963847,
-0.029954655,
0.0013068089,
0.010326402,
-0.02604518,
-0.02173128,
-0.022998488,
0.017538706,
-0.016190613,
-0.014424609,
-0.01774092,
-0.017943135,
-0.019655215,
-0.0029085134,
-0.02616651,
-0.004873361,
0.017606111,
-0.023362473,
0.00858062,
-0.0066562155,
-0.03917562,
-0.049960375,
-0.002274909,
0.008708689,
-0.03960701,
-0.037962336,
-0.025236325,
0.05144328,
0.016689407,
0.0006475065,
-0.019641733,
-0.01415499,
0.021920012,
-0.020679766,
-0.0037139996,
-0.022553617,
-0.016204093,
-0.019102495,
-0.0023574799,
0.019331671,
-0.0131304385,
-0.020032682,
-0.009517546,
0.026921442,
-0.016878141,
0.027932514,
-0.005806916,
-0.011020671,
0.009901753,
0.030143388,
0.029361494,
0.00801442,
-0.0071853423,
-0.010130929,
-0.019102495,
-0.00024981872,
-0.03205768,
-0.0031781322,
-0.008492994,
-0.010481433,
0.0077852444,
-0.011923893,
0.0014205544,
0.006989869,
-0.011843008,
0.009167041,
0.012786674,
0.032974385,
0.026409166,
0.009369255,
0.01830712,
-0.0052710488,
-0.011061113,
-0.006524776,
-0.008978308,
0.02876833,
-0.006942685,
-0.024764491,
0.034403365,
0.009908493,
-0.009389477,
-0.01501777,
-0.0043004206,
-0.025182402,
0.04618571,
-0.01616365,
-0.016527636,
-0.002044048,
-0.018563258,
0.007947016,
-0.012901262,
0.020598881,
-0.0009268148,
-0.011681236,
-0.020342743,
-0.0026624862,
-0.01918338,
-0.011876711,
-0.03877119,
-0.014990808,
0.02944238,
-0.007650435,
-0.0002624571,
0.012847338,
0.013467462,
0.009355774,
-0.0062180846,
-0.0065146657,
-0.029685035,
0.0055844807,
-0.008263818,
0.019142939,
0.013993219,
0.02531721,
-0.0060327216,
0.032489073,
0.022823235,
0.013184362,
-0.0021198783,
-0.0077852444,
0.017498264,
-0.018927243,
0.03230034,
0.015530046,
0.0002651954,
0.015813146,
-0.003589301,
0.019803505,
0.028229093,
-0.00020274073,
-0.04394787,
0.0005105907,
-0.04963683,
-0.029738959,
0.017188203,
-0.02231096,
-0.015920993,
-0.02045059,
-0.0027214652,
-0.0028411087,
-0.0026254135,
0.031275786,
-0.012631644,
0.03634462,
-0.0115329465,
0.027959475,
-0.017323012,
0.017228644,
-0.0068415785,
-0.009119858,
-0.0064135585,
0.013979738,
0.03103313,
0.02345684,
0.018118387,
-0.012597941,
0.00032354263,
-0.0064270394,
0.026085624,
-0.016433269,
-0.0031090423,
-0.01772744,
-0.034484252,
-0.0028411087,
-0.015152579,
0.009652355,
-0.044244453,
0.013238286,
-0.018657625,
-0.0058136564,
0.006551738,
-0.0017946505,
0.0011922208,
0.024481392,
0.013831447,
0.026490053,
-0.018751992,
0.01786225,
-0.00032986182,
0.006103497,
-0.03691082,
-0.01989787,
-0.026099104,
0.021192042,
0.03149148,
0.015193023,
-0.034699947,
0.0006652003,
0.0053451937,
-0.004923914,
-0.027689856,
-0.054004658,
-0.006211344,
-0.01701295,
0.02272887,
0.0035960414,
0.004388047,
-0.021259446,
0.024926264,
-0.0041251685,
0.01644675,
0.0036769272,
-0.002472068,
-0.005779954,
0.037018668,
0.00914682,
0.03230034,
0.011553168,
-0.018630663,
0.0018131868,
-0.023928674,
0.006548368,
-0.0036567056,
-0.012651864,
0.024858858,
-0.015718779,
-0.016284978,
0.0088165365,
0.013858409,
-0.008182933,
-0.007360595,
-0.0011096501,
0.041009028,
-0.017808326,
-0.0012469871,
0.01616365,
0.007980718,
-0.0047554024,
0.015772702,
0.005463152,
-0.015610931,
-0.022647984,
0.0031225234,
0.026543977,
0.012624903,
-0.00008451919,
-0.040146247,
-0.010339883,
0.021839127,
-0.049582906,
-0.0200192,
0.0009942196,
-0.049663793,
-0.00858736,
0.0051497202,
0.017794844,
0.036695126,
0.0063293027,
-0.0018502594,
-0.018644143,
0.026206952,
0.0026388946,
0.0072257854,
0.011917153,
-0.016096245,
-0.0323273,
0.000042654545,
-0.0064607416,
-0.027137138,
0.022540135,
-0.02057192,
-0.025937334,
0.007893092,
0.0023810714,
0.03734221,
0.019372115,
-0.004273459,
0.0037578128,
-0.0028866068,
0.03461906,
0.0027197802,
-0.020127047,
0.015287389,
-0.044810653,
-0.011600351,
0.021488622,
-0.018037502,
-0.01744434,
-0.011499244,
-0.014963847,
-0.00958495,
-0.009766943,
-0.0004210688,
-0.010474692,
-0.008054864,
0.0007486136,
-0.0033854018,
0.011816046,
-0.0492324,
-0.007994199,
-0.006480963,
-0.00073176244,
-0.0014121288,
-0.022068303,
-0.014357204,
0.020194452,
0.030628702,
-0.0037982557,
0.0061978633,
0.007023571,
-0.027959475,
-0.037692714,
0.013979738,
-0.01101393,
0.031949833,
0.0042094244,
-0.018819395,
-0.014181952,
-0.01658156,
-0.04319294,
-0.0038926222,
-0.0128877815,
-0.001694386,
0.013224805,
0.00858736,
-0.005304751,
0.0079537565,
-0.0026068774,
0.0052878996,
0.0074684424,
-0.007913313,
0.004506005,
-0.009908493,
0.0101713715,
0.020383185,
-0.01757915,
0.005233976,
0.037396137,
0.01929123,
0.00032354263,
0.035427917,
0.004762143,
0.0064877034,
0.0014550992,
0.027905552,
-0.0005851572,
0.015395236,
0.024076963,
-0.036101963,
-0.023834307,
-0.0045801504,
-0.00078231597,
-0.011000449,
0.02074717,
-0.02189305,
-0.01631194,
0.014101066,
-0.0059282444,
-0.032704767,
0.014775113,
-0.022661464,
0.009672577,
0.017713958,
0.007407778,
0.008621063,
0.015193023,
0.0060664243,
-0.01472119,
-0.0031023019,
-0.027635932,
0.0026978736,
-0.012611422,
-0.01058928,
0.017673517,
-0.016258016,
-0.0049980595,
0.0021063972,
-0.010333142,
0.015125617,
-0.008964827,
-0.03275869,
0.02316026,
0.00514298,
-0.006245047,
-0.012496834,
-0.0018098166,
0.0011138628,
-0.016851177,
0.008088565,
-0.010353364,
-0.008600841,
0.0021063972,
-0.0071314187,
-0.028094284,
-0.014343723,
-0.017767882,
-0.015503084,
-0.00075788173,
0.024400506,
0.19337064,
0.0014449885,
0.0039532864,
0.0100500425,
0.009908493,
-0.009045713,
-0.000014376162,
0.0012891152,
-0.01330569,
0.00015819044,
0.009827607,
0.0032674435,
-0.014707709,
0.005918134,
0.01631194,
-0.016204093,
-0.0046542953,
-0.0060866456,
-0.03917562,
0.0030450078,
0.03602108,
-0.013561828,
0.0037712937,
0.008830017,
0.015759222,
-0.02644961,
-0.012914743,
-0.0030719698,
-0.014815556,
0.010117447,
-0.050957963,
0.007306671,
-0.00801442,
-0.024818415,
-0.019210344,
0.0000641398,
0.0049272845,
-0.0030989316,
-0.013170881,
0.0121530695,
-0.011694718,
-0.012173291,
0.036722086,
0.009908493,
0.00048868416,
-0.000017693737,
0.0056956983,
0.0025293618,
0.0020491034,
-0.0048261774,
-0.053438455,
0.0067269905,
0.023686016,
0.03116794,
0.0027972956,
-0.008209894,
0.00815597,
0.0051867925,
-0.011081335,
0.021663874,
-0.009382736,
-0.006352894,
-0.014788594,
-0.0097265,
-0.0027484272,
0.024629682,
-0.026975365,
0.0009352404,
0.03149148,
-0.024872338,
0.018185792,
-0.010683647,
-0.013635973,
-0.019776544,
-0.012051962,
-0.007818947,
0.03491564,
0.018320601,
0.035940193,
0.018994648,
0.0062416764,
0.0009975898,
-0.025492463,
0.00017672674,
0.015759222,
-0.021245966,
0.0411708,
0.0030905062,
-0.017767882,
-0.0056384043,
0.006908983,
-0.011526206,
-0.0019294599,
-0.012436169,
0.010373585,
0.00039642397,
0.0205854,
0.0100096,
-0.016972506,
-0.016985988,
-0.0134405,
0.05877691,
-0.0052541974,
-0.019978756,
-0.0041420194,
-0.004563299,
0.00095124904,
-0.00047309682,
-0.007219045,
-0.013251767,
0.0066427346,
-0.036668163,
-0.002947271,
-0.0032826096,
-0.0026725968,
0.009989378,
-0.0045936313,
-0.0454847,
0.045673434,
-0.013029331,
0.0039128438,
-0.028417828,
-0.00005429239,
0.038555495,
0.0022378364,
-0.01530087,
-0.010906083,
-0.001365788,
-0.029550226,
-0.024481392,
0.009948935,
0.0039027329,
0.016999468,
0.00571929,
-0.016675927,
-0.023079373,
-0.0052676783,
-0.006807876,
-0.015004289,
0.01601536,
-0.0078324275,
-0.018091425,
-0.0026574307,
0.0021266188,
-0.02245925,
-0.013521385,
0.005351934,
0.025344172,
-0.036155887,
-0.02774378,
0.0014584694,
-0.018751992,
-0.0009883216,
0.0033584398,
0.009470362,
-0.026233915,
-0.018711548,
-0.045134194,
-0.018698068,
0.03507741,
-0.016527636,
0.016096245,
0.006022611,
0.0143706845,
-0.010656686,
0.0028866068,
-0.16953634,
-0.0036600758,
0.00643041,
-0.023901712,
-0.001402018,
0.024050001,
0.0061944933,
-0.005362045,
-0.0029641222,
-0.0032859799,
0.034646023,
0.011020671,
-0.054705665,
-0.030224273,
0.0028764962,
0.009308591,
-0.014235876,
0.020315781,
0.008182933,
-0.007947016,
0.012483353,
-0.026382204,
0.024589239,
0.014842518,
-0.004027432,
0.026557457,
-0.017511744,
-0.010757792,
-0.012328322,
-0.014343723,
-0.010016341,
0.0022563727,
0.036802974,
-0.012624903,
0.013993219,
-0.010184852,
-0.0060091303,
-0.0028259426,
0.0068179867,
-0.0054597817,
0.035832345,
0.00872891,
0.021475142,
-0.012510315,
0.012388987,
0.045269005,
-0.005688958,
0.0053418237,
0.029981617,
-0.015273908,
0.011896932,
-0.012847338,
0.017889211,
0.016379345,
0.013514645,
0.023766901,
-0.004745292,
0.030979207,
-0.009369255,
0.00915356,
-0.0040678745,
-0.016123207,
0.030682625,
-0.025829487,
-0.0054429304,
-0.02644961,
0.00032986182,
0.0061102374,
-0.031976797,
0.014802075,
0.004192573,
0.01144532,
0.0030905062,
-0.023281587,
0.023268107,
0.015570489,
-0.009349034,
0.022337923,
-0.0002963701,
-0.015624412,
-0.017120797,
0.033945013,
-0.026624862,
-0.0334597,
-0.026341762,
0.005537297,
-0.00066899176,
0.014613342,
0.0011020671,
0.0047318107,
-0.001157676,
-0.017552188,
0.00543282,
-0.009416439,
0.030008579,
0.011243106,
-0.033432737,
-0.010346623,
0.0072864494,
-0.0057159197,
0.010622983,
-0.01629846,
-0.018091425,
0.004745292,
0.03505045,
0.001744097,
-0.0019395706,
0.0016362494,
0.045026347,
-0.0037106294,
-0.0109195635,
-0.0069561666,
0.022499694,
0.033540584,
0.0024046632,
0.009699538,
-0.004307161,
0.013737081,
0.005675477,
-0.012368765,
0.078782625,
-0.023483802,
-0.025519425,
-0.00011532525,
0.013602271,
-0.017633073,
-0.12628947,
-0.006423669,
-0.015651375,
0.031410597,
-0.016379345,
0.004492524,
0.009861309,
0.026072143,
-0.006083275,
0.021906532,
-0.039121695,
-0.0016227685,
0.0016758497,
0.009618653,
-0.01244291,
0.003633114,
0.010117447,
-0.016648965,
-0.011667755,
0.03491564,
0.011377916,
0.0049744677,
-0.0067438413,
-0.015920993,
0.037126515,
0.012685567,
-0.03731525,
0.021488622,
0.016500674,
0.011822787,
-0.01044099,
-0.01829364,
0.008594101,
0.017417379,
-0.035239182,
-0.009214224,
-0.0044689323,
-0.020598881,
0.034565136,
-0.006022611,
0.010764533,
0.0016497304,
0.025182402,
0.0014028606,
0.012314841,
-0.0002746742,
-0.0065146657,
0.023766901,
0.01613669,
-0.004644185,
-0.040308017,
-0.003233741,
-0.032003757,
-0.021839127,
0.018967686,
-0.036371585,
0.00829752,
0.018253196,
-0.014694228,
-0.0028680705,
-0.0037780341,
-0.0009992749,
0.0046138526,
-0.0019816987,
0.008985048,
-0.009679317,
-0.010312921,
-0.031383634,
0.026490053,
-0.026220433,
-0.011613832,
0.013602271,
-0.025559867,
0.0064843334,
-0.032704767,
-0.012982148,
-0.020639323,
-0.0040813554,
0.006935945,
-0.01857674,
-0.007967237,
-0.029064912,
0.014842518,
-0.035508804,
0.019870909,
0.01658156,
0.012604682,
-0.0075291065,
0.01744434,
0.0031831877,
-0.0016387771,
0.032408185,
0.010515136,
-0.012233956,
-0.012294619,
0.017430859,
-0.004664406,
-0.00715164,
0.017215164,
0.02402304,
-0.028229093,
0.0019378855,
-0.0703166,
0.01602884,
0.0082031535,
-0.008708689,
0.009766943,
-0.019614771,
-0.00043728808,
0.016716368,
-0.009416439,
0.023982598,
-0.015786184,
0.004074615,
-0.013359614,
-0.019601291,
-0.03642551,
-0.010535357,
0.04518812,
-0.012415948,
0.015691817,
0.0068887617,
-0.009483843,
-0.009888272,
0.0076302136,
0.040955104,
-0.0071583805,
-0.005688958,
-0.011701458,
0.007326892,
-0.0101713715,
0.018603701,
0.033109196,
-0.046536215,
-0.018967686,
0.010124188,
0.0055002244,
-0.0051834225,
-0.028525675,
0.022567097,
0.013710119,
0.03445729,
-0.027110176,
-0.028094284,
-0.0039094733,
0.0121463295,
-0.0009352404,
0.017336491,
-0.024252215,
0.004155501,
0.0056417743,
-0.003161281,
0.039984476,
0.020855019,
0.0027484272,
-0.018050982,
-0.017403897,
-0.007778504,
-0.003791515,
0.00500143,
0.012058703,
-0.03488868,
0.0064573716,
0.034079824,
0.028229093,
0.011620573,
-0.010899342,
-0.002129989,
-0.0151121365,
-0.015624412,
-0.010023081,
-0.034807794,
-0.01172168,
0.009052453,
0.018226234,
0.0061473097,
-0.010232035,
0.0026220432,
-0.005604702,
-0.015044732,
-0.0074617015,
0.009504065,
0.016824216,
0.0065685892,
-0.012078925,
0.015570489,
0.034726907,
-0.023362473,
0.0017744291,
0.023106337,
-0.0131371785,
0.010157891,
0.003602782,
0.025856448,
0.02216267,
0.014707709,
-0.005490114,
0.020989828,
-0.013939295,
0.0022378364,
0.01272601,
0.005837248,
-0.0143706845,
0.0033651802,
0.005072205,
-0.0035151558,
-0.009335552,
0.038717266,
-0.036263734,
-0.025546387,
0.0012629958,
0.004364455,
0.03674905,
0.00006987973,
0.020976346,
0.0003616684,
-0.011317251,
-0.005604702,
0.013386576,
-0.0026220432,
-0.0075628087,
0.014141508,
0.0026153028,
0.018212754,
-0.00328935,
0.011634054,
0.031599328,
0.000489948,
0.027689856,
-0.018536296,
0.017255606,
-0.0054867435,
0.03763879,
-0.02201438,
-0.017080354,
-0.019196862,
-0.015395236,
0.009349034,
0.00300288,
0.026692266,
0.010643205,
0.09770987,
0.017794844,
-0.010811716,
0.008850239,
-0.006302341,
0.0094434,
-0.0020271968,
0.00543282,
-0.011081335,
-0.025411576,
0.01586707,
-0.025088035,
0.008344703,
-0.009328812,
-0.013063033,
-0.007906573,
-0.006393337,
0.017511744,
-0.0037139996,
-0.0036432247,
0.008223375,
-0.015907513,
0.019965276,
0.024710568,
-0.014451571,
-0.0028411087,
0.019992238,
0.0024670125,
-0.0004554031,
-0.022688426,
0.017066874,
-0.007326892,
-0.04934025,
-0.006804506,
-0.0009428234,
0.000010374007,
-0.005955206,
0.0011947486,
0.02746068,
0.016352383,
0.007913313,
-0.029064912,
0.0041116877,
-0.013386576,
0.006733731,
-0.005820397,
0.021866089,
0.0010211813,
-0.009322071
] |
The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. Combining this unique resource with gene expression data demonstrates distinct temporal mechanisms of estrogen-mediated gene regulation, particularly in the case of estrogen-suppressed genes. Furthermore, this resource has allowed the identification of cis-regulatory sites in previously unexplored regions of the genome and the cooperating transcription factors underlying estrogen signaling in breast cancer. | [
-0.044015877,
-0.023263292,
-0.027382426,
-0.019837221,
-0.009696308,
0.007473284,
-0.010703207,
0.01825495,
-0.034417644,
-0.025290169,
-0.006240813,
-0.013730443,
-0.007264058,
0.013991975,
-0.018882629,
0.0051162243,
0.047677327,
-0.013429681,
-0.0046879654,
0.0035960684,
-0.014998875,
0.014044281,
0.0027820494,
-0.003566646,
-0.017823422,
0.018359564,
0.020334132,
-0.038994458,
-0.0129981525,
-0.018738786,
0.009428238,
0.017300358,
-0.01679037,
-0.0006452491,
-0.004756618,
0.014881184,
0.0066167656,
-0.021746406,
0.0024910946,
-0.008061731,
0.008061731,
0.0022491773,
0.0077413544,
0.014920414,
-0.0048383465,
-0.020464897,
0.029866982,
-0.015835777,
-0.013351221,
0.021262571,
-0.014946568,
0.012357399,
-0.018804168,
-0.016842676,
-0.039072916,
0.0056719803,
0.011690491,
0.01910493,
0.010716284,
0.0031514636,
-0.015508862,
-0.01617577,
-0.033554588,
0.009637463,
0.0038968304,
0.028533168,
0.0009120937,
0.021681024,
-0.0006881567,
0.00918632,
0.03188078,
0.016214998,
-0.020674124,
0.025355551,
0.010467828,
-0.043335892,
-0.021288725,
-0.009774768,
0.016633451,
-0.007434054,
0.015299636,
-0.0006117403,
-0.010480905,
0.005452947,
0.008519413,
0.0011074255,
0.015914237,
0.0004241726,
0.004177978,
-0.0067409934,
0.024557877,
0.025564777,
0.009055554,
0.026035534,
-0.006721379,
0.0045016236,
0.010605132,
0.011383191,
0.017574966,
-0.022831764,
0.018804168,
0.018594943,
0.00094478525,
-0.0070548323,
-0.036222216,
-0.004933152,
-0.003720296,
-0.007584435,
0.02709474,
-0.006172161,
-0.018594943,
0.023014838,
-0.008382108,
-0.02701628,
0.05821708,
0.0049364213,
0.016698834,
0.0053842952,
-0.0003575636,
0.0062113907,
0.01578347,
0.023550978,
0.007917888,
-0.02651937,
0.0052731438,
-0.0066363807,
-0.019039547,
-0.00094560254,
-0.011422421,
0.0012128558,
0.01235086,
-0.011821258,
0.00459316,
0.004573545,
-0.024557877,
-0.0015740972,
-0.014933491,
-0.017653426,
-0.014488886,
-0.040459037,
-0.0015144352,
0.025107095,
-0.033031523,
0.004482009,
-0.012475088,
0.0015389537,
0.0210795,
0.0031776167,
0.029422378,
0.01667268,
-0.006727917,
-0.015325789,
0.00887902,
-0.007839429,
0.00687176,
-0.003671259,
0.0060315873,
0.03331921,
-0.0017261128,
-0.024910945,
0.03878523,
-0.0010191585,
0.0026496486,
0.032246925,
0.027748572,
0.024074042,
0.018843397,
-0.012128558,
-0.0056523657,
-0.007309826,
-0.007329441,
0.012370476,
-0.026990127,
0.0115728015,
-0.008604411,
0.02551247,
-0.030677732,
0.02381251,
-0.014671959,
-0.002940603,
-0.011069352,
-0.0016672681,
0.013187763,
-0.01242932,
-0.005747171,
-0.00051162246,
0.013096227,
-0.021131806,
0.0010820896,
-0.02462326,
0.00024416487,
0.0320377,
0.026545523,
-0.007930965,
-0.6335357,
0.0010158893,
-0.0080944225,
-0.0105920555,
0.0031596364,
0.012337783,
0.009219011,
-0.018895704,
-0.010212834,
0.017771116,
-0.014057358,
-0.0060315873,
0.018477254,
-0.009107861,
-0.037660643,
-0.043283585,
-0.01370429,
0.0064990763,
0.029030079,
0.0026414758,
-0.021707177,
0.0016468358,
-0.0061427387,
0.027513193,
0.0125077795,
0.0067606084,
0.009140552,
-0.017038826,
0.022112552,
0.032586917,
-0.02315868,
0.032560766,
-0.018241875,
0.009670155,
0.045375843,
-0.0052894894,
-0.0050737257,
0.022975607,
0.041452862,
0.038026787,
0.003524147,
0.012501242,
0.04179285,
0.0025025366,
-0.0044885473,
0.016881905,
0.005681788,
0.0140704345,
0.014031205,
-0.008120576,
-0.008408261,
0.007623665,
-0.011017046,
-0.007754431,
0.0213018,
0.007434054,
0.027539345,
-0.022361007,
-0.0039000995,
-0.015064257,
0.012023945,
0.015705012,
-0.014645806,
-0.027722418,
-0.0002498859,
0.023681745,
-0.015757319,
0.011147812,
-0.0076563563,
0.012135096,
0.021563334,
0.030625425,
0.0054823696,
-0.006427155,
0.017078055,
0.045375843,
-0.0025483049,
0.006185238,
0.014122741,
0.020674124,
0.004465663,
-0.003632029,
-0.028768547,
0.007976733,
0.024414035,
-0.027722418,
-0.019327233,
0.0115728015,
0.0063879252,
0.0047075804,
0.0059073595,
-0.0076171267,
-0.015744241,
-0.022478696,
-0.033266902,
0.011664338,
0.026963973,
0.01184741,
0.00540391,
-0.034103803,
-0.015378096,
-0.005704672,
-0.0017310166,
0.00058395247,
0.0062440825,
-0.0010477635,
-0.011494342,
0.007538667,
0.009290933,
-0.017574966,
-0.0077478928,
-0.0028556052,
-0.016881905,
0.0038183709,
-0.014018129,
-0.014135818,
0.0041518244,
0.03229923,
-0.0033018445,
-0.0054169865,
0.031776167,
0.015025027,
-0.0055379453,
-0.009663616,
0.023838663,
-0.0031661747,
-0.003916445,
-0.0053842952,
0.0008360859,
-0.015796548,
0.017326511,
-0.025420934,
0.00063380704,
-0.028428555,
0.0014743881,
0.008257881,
0.020661047,
0.00004349506,
0.014920414,
-0.012913154,
-0.014449656,
-0.0070221405,
0.009467468,
0.019484153,
-0.013403527,
-0.01084705,
-0.016489608,
0.0049593053,
-0.0033672277,
-0.008061731,
-0.011474728,
-0.010454752,
-0.005410448,
0.017339587,
0.011219733,
-0.009264779,
-0.008015963,
-0.010114759,
-0.0066363807,
-0.0010641093,
0.0041747084,
0.009362854,
-0.0027836838,
-0.0287947,
-0.009552465,
-0.015443479,
-0.008709024,
0.020046446,
-0.034679174,
-0.028271636,
0.004266245,
-0.0040504807,
-0.0142927375,
0.006515422,
0.0042923978,
0.015548092,
-0.017496508,
-0.023459442,
-0.0060740863,
-0.010833973,
-0.014083511,
-0.023014838,
-0.021471797,
0.011938947,
0.04600352,
0.016803447,
0.01926185,
-0.013678136,
0.011402806,
-0.003033774,
-0.036692973,
0.016450379,
-0.014475809,
0.036849894,
0.019627996,
-0.035228394,
0.024348652,
0.022831764,
0.0039131762,
0.012292015,
0.015678858,
-0.011507419,
0.030259281,
-0.006430424,
-0.009794382,
-0.02740858,
0.0075975116,
0.008689409,
0.007394824,
-0.010016685,
0.008506336,
0.019967986,
0.0037268344,
-0.008205574,
0.007362133,
0.0060479334,
0.0061786994,
-0.00034959507,
0.007277135,
0.0038314473,
-0.0055444837,
0.02226947,
0.006982911,
-0.005511792,
0.004187785,
0.024230963,
0.022635616,
-0.02910854,
0.015221177,
0.0056981337,
0.0014637633,
0.0065481137,
-0.00798981,
0.020164136,
0.0073163644,
-0.013037383,
0.018098032,
-0.0016337592,
0.01756189,
-0.00078296213,
-0.004737003,
0.0028392593,
0.016960366,
0.010637824,
-0.011683953,
-0.018150337,
0.023995584,
0.022818688,
-0.0012594413,
-0.007159445,
0.0050083427,
0.006727917,
-0.012717006,
0.024335576,
0.012102405,
0.010742437,
0.02088335,
0.019458,
0.05021419,
0.020137982,
0.032560766,
0.006642919,
-0.008983633,
-0.0040439423,
-0.013109304,
0.013390451,
0.0174442,
-0.004249899,
-0.019274926,
0.003654913,
-0.018464176,
0.011272039,
0.009310548,
-0.015129641,
0.0018536098,
0.0026153224,
-0.00047770498,
0.030546967,
0.012985076,
0.0013771307,
-0.00297166,
-0.026963973,
0.039962128,
0.030259281,
-0.006597151,
0.0062211985,
-0.015744241,
-0.0058975522,
0.006338888,
0.0004166127,
0.045401998,
0.0010984354,
-0.0033100175,
0.005936782,
-0.026192455,
0.0142927375,
0.018895704,
-0.029971596,
-0.0057569784,
-0.00005935556,
0.022844842,
-0.03407765,
0.008159806,
0.0005659721,
0.032743838,
0.0038118325,
-0.020713354,
-0.009029401,
-0.01864725,
-0.031828474,
0.0012888636,
-0.0041812467,
0.004495085,
-0.04079903,
-0.00093661237,
-0.004691235,
0.017234975,
0.0030582927,
0.018202644,
-0.018778015,
-0.0015332327,
-0.0033508819,
0.019026471,
0.008042117,
0.026728595,
0.0059531275,
-0.006620035,
0.0048808455,
-0.0128216185,
-0.004550661,
-0.02910854,
-0.010127836,
0.00040987006,
-0.0021723523,
0.0026643598,
0.00922555,
0.011670876,
-0.009977455,
0.0053744875,
0.012684314,
0.0054921773,
-0.052306447,
-0.0137565965,
-0.009624386,
0.0117493365,
-0.00008806281,
0.026310144,
0.038811386,
0.03569915,
-0.021746406,
0.018974165,
0.021641793,
0.01914416,
-0.015508862,
-0.0046618124,
0.031122336,
0.009016324,
0.017522661,
0.0065611904,
-0.013403527,
0.012730082,
-0.0055019846,
-0.0058615915,
0.00036532784,
0.01289354,
0.015574245,
0.02648014,
0.022230241,
0.0021069692,
-0.014528116,
0.013416604,
0.006897913,
-0.000061092294,
-0.032796144,
0.0012349226,
-0.022818688,
-0.02910854,
-0.03392073,
0.00482527,
-0.016358841,
0.013887363,
-0.024924023,
-0.028245483,
-0.0029978133,
-0.008238265,
-0.006688687,
0.015953466,
-0.0059498586,
-0.0020154328,
-0.00066895044,
-0.018111108,
-0.016999597,
0.0028196445,
-0.0059858193,
0.00046830619,
-0.031357717,
-0.032194618,
0.009140552,
0.04210669,
0.01154011,
0.013560447,
0.004334897,
0.008447492,
0.017718809,
-0.0049429596,
-0.026807055,
0.00953285,
-0.037843715,
0.006208122,
-0.011213195,
0.01876494,
-0.02258331,
-0.03373766,
0.016921137,
0.014305814,
-0.0110366605,
0.052463368,
-0.009545927,
-0.017274205,
0.042368222,
0.0060315873,
0.024296345,
0.016515762,
-0.012056637,
-0.012409705,
-0.017548814,
-0.02396943,
-0.022674846,
-0.0101016825,
-0.01069013,
0.006381387,
0.00540391,
-0.027879337,
0.00010747341,
0.016803447,
-0.02400866,
0.0016051541,
0.0085847955,
0.0011858853,
0.010938586,
-0.008120576,
0.020124907,
-0.005855053,
0.0013174687,
0.0107685905,
-0.015548092,
0.025329398,
-0.003207039,
-0.025002483,
-0.0030321395,
-0.01748343,
0.002030144,
-0.015822701,
-0.0007878659,
0.0014408792,
0.03551608,
-0.009807459,
-0.014240431,
-0.0067148404,
-0.010552826,
-0.0095655415,
-0.009219011,
0.015731165,
-0.016463455,
-0.031122336,
0.019588765,
-0.011906255,
-0.030311586,
0.004419895,
-0.02620553,
-0.005279682,
0.017117286,
-0.0031171374,
0.015731165,
0.013050459,
0.0063356184,
0.00023885249,
-0.019732608,
-0.016149616,
-0.038628314,
-0.0040275967,
-0.005554291,
0.029082386,
0.03169771,
0.034234572,
0.014933491,
-0.0069436813,
0.018058801,
0.0042139385,
0.013717366,
-0.010153989,
0.029919289,
-0.005279682,
0.030886957,
0.0021020654,
-0.00079481286,
0.015351943,
-0.013599677,
0.008656717,
0.011906255,
-0.014528116,
-0.011363576,
-0.0030157936,
-0.034208417,
-0.047572713,
0.023014838,
-0.0076825097,
0.02015106,
-0.03616991,
0.008656717,
0.021707177,
0.0013902073,
0.032246925,
-0.01764035,
0.014462733,
-0.019654147,
0.0060773557,
-0.01088628,
0.013495063,
-0.0320377,
-0.020464897,
0.003419534,
-0.0112589635,
0.017156515,
0.0031400216,
0.028245483,
-0.002894835,
-0.015835777,
0.017718809,
0.0017457277,
-0.030233128,
-0.01728728,
-0.0010085338,
-0.025277091,
0.008604411,
-0.0010869934,
-0.01053975,
-0.024924023,
-0.01817649,
0.009820536,
-0.011409344,
0.01876494,
-0.008950941,
-0.007911351,
0.019941833,
-0.0006146008,
0.012023945,
-0.006819453,
0.0300239,
0.020321056,
0.0047304644,
-0.009134013,
-0.015155793,
-0.0117493365,
0.005877937,
0.030128514,
0.0056490963,
-0.0033574202,
0.00042580717,
0.019209543,
0.01235086,
-0.01324007,
-0.004191054,
-0.0101016825,
-0.012089328,
-0.008257881,
-0.0014564077,
-0.009912072,
-0.0065448442,
-0.008185959,
-0.030886957,
0.019039547,
-0.007434054,
-0.0077086627,
-0.01849033,
0.025996305,
-0.019366462,
0.010428598,
0.0044885473,
-0.019392615,
-0.0008990171,
-0.01655499,
0.0022475426,
-0.0062571587,
-0.008525951,
0.024636338,
-0.02196871,
0.0005005891,
0.016489608,
-0.006240813,
-0.010461289,
-0.002111873,
-0.014057358,
0.043466657,
0.004377396,
-0.007224828,
0.0072575198,
0.0016934213,
0.0021363916,
0.015822701,
-0.0084148,
-0.0013591504,
-0.022060245,
-0.01655499,
0.007388286,
0.015835777,
-0.013599677,
-0.005126032,
-0.020321056,
-0.006884836,
-0.033816118,
-0.01184741,
0.015338866,
-0.038314473,
-0.0039458675,
0.006404271,
0.030050054,
0.060884707,
0.011808181,
0.00085243164,
-0.0011270405,
0.0271732,
-0.015103487,
0.022766382,
0.010049377,
0.001721209,
-0.018961087,
0.008944402,
-0.008578258,
-0.035019167,
-0.0077086627,
-0.018974165,
-0.017888805,
-0.023145603,
-0.009487082,
-0.0025760925,
0.03878523,
-0.021589486,
0.011095505,
0.011513957,
0.02242639,
-0.00521103,
-0.01072936,
-0.0041747084,
-0.01586193,
0.00957208,
0.020294903,
-0.001984376,
-0.0061819684,
-0.025878616,
-0.016345765,
0.0213018,
0.019575689,
0.009428238,
-0.017248051,
0.0071267537,
-0.008369031,
0.0034031884,
0.016293459,
-0.015992697,
-0.023433289,
0.018320333,
0.008002887,
-0.012867386,
-0.018621096,
0.009800921,
-0.0058746682,
0.014122741,
-0.018895704,
-0.01914416,
-0.015221177,
-0.030546967,
-0.037582185,
-0.0025809964,
-0.013913515,
0.021354107,
0.02300176,
-0.035228394,
-0.04372819,
-0.005900821,
-0.036849894,
-0.02790549,
0.00045768142,
0.01930108,
-0.0011867025,
0.027696265,
-0.0016337592,
0.0036581822,
-0.01157934,
0.008087885,
-0.0006370762,
-0.021824867,
0.0029781985,
-0.013848132,
0.0020759122,
0.019719532,
-0.04323128,
-0.020451821,
0.05207107,
-0.014685036,
-0.037817564,
0.017117286,
-0.028820854,
0.027853183,
-0.014907338,
-0.0015986159,
-0.003481648,
0.02485864,
0.030939264,
-0.030520814,
0.003184155,
0.026833208,
0.006489269,
-0.012579701,
0.00044787396,
-0.01370429,
0.0064010015,
0.0067802235,
-0.018189568,
-0.01764035,
0.0055837133,
-0.003916445,
0.0050050733,
0.01987645,
-0.0001884871,
0.028402401,
0.010317447,
-0.003377035,
-0.019824143,
-0.02547324,
-0.005358142,
0.012573163,
0.0013902073,
-0.015691934,
-0.011605494,
-0.01069013,
-0.018594943,
-0.006384656,
0.009885919,
0.0034783788,
-0.034051497,
-0.026506294,
0.004142017,
0.00014527299,
-0.026375527,
-0.020739507,
-0.010088607,
-0.012174326,
-0.029265458,
-0.013155072,
-0.0062277364,
-0.009951302,
-0.012873924,
-0.007002526,
-0.007800199,
0.007924427,
-0.003883754,
-0.0011499246,
-0.023995584,
0.021131806,
0.19363847,
-0.016398072,
-0.030102361,
0.009402084,
0.010873203,
-0.0088528665,
0.011160889,
0.009905534,
-0.0054267943,
0.007349056,
0.014096588,
-0.0006848876,
-0.009559004,
-0.0025466701,
0.005041034,
-0.004230284,
-0.022256395,
-0.0025352282,
-0.019405693,
0.0008622391,
0.033266902,
-0.0021592756,
0.0018307257,
-0.023603285,
0.0426036,
0.0075452053,
-0.025996305,
0.012632008,
0.019444922,
-0.00640754,
-0.028847007,
0.025146326,
0.01686883,
-0.0010436771,
0.0011049737,
-0.002764069,
-0.0018863013,
-0.0101016825,
-0.005194684,
-0.021367185,
-0.00802904,
0.037111424,
-0.010252064,
0.0011817989,
0.013155072,
0.0033198248,
-0.018621096,
-0.008061731,
-0.0057635168,
-0.009526312,
-0.03373766,
0.024400959,
-0.004573545,
0.029370071,
0.0040668263,
0.0062440825,
0.02311945,
0.013730443,
0.008519413,
0.012193941,
-0.011056276,
-0.001063292,
-0.03169771,
0.008087885,
-0.015705012,
0.03269153,
-0.026061688,
0.0012733351,
0.024597108,
-0.0075452053,
0.00999707,
0.0050769947,
-0.010474366,
0.023616362,
-0.0013705924,
0.0006456577,
0.018673401,
0.009624386,
0.031985395,
0.023734052,
0.006319273,
0.004312013,
-0.039229836,
-0.013638906,
0.014933491,
-0.036431443,
0.02138026,
0.00143761,
-0.0078067374,
-0.011677415,
0.008774407,
-0.00918632,
-0.008251342,
0.0032707877,
0.01586193,
-0.0028457977,
-0.023184834,
0.023067145,
-0.03114849,
0.004802386,
-0.030206975,
0.06878298,
-0.0032282886,
0.009931687,
0.008454029,
0.019941833,
-0.011226271,
0.014122741,
-0.012442397,
-0.0033345362,
0.019889528,
-0.012207017,
0.0014073704,
-0.013416604,
-0.030520814,
0.027225507,
0.029265458,
-0.015351943,
0.014175047,
-0.015639627,
-0.029971596,
-0.027722418,
0.0014596769,
0.032456152,
-0.007244443,
0.010755514,
-0.017274205,
-0.019248772,
-0.025264015,
-0.023956353,
0.0009782941,
0.0076432796,
0.0039654826,
0.011324346,
0.011003969,
-0.042655908,
0.03172386,
0.0038412549,
-0.024348652,
0.043048207,
-0.008709024,
-0.009755152,
0.0025499393,
0.029265458,
0.0026463794,
-0.035463773,
-0.0023962893,
0.00436105,
-0.006721379,
0.017404972,
-0.01714344,
-0.009068631,
-0.013024306,
0.013024306,
0.032665376,
-0.010696669,
-0.032429997,
-0.041975927,
-0.011049737,
0.013403527,
-0.014658882,
0.0024191733,
0.03779141,
-0.0040962487,
-0.0022132166,
0.016097309,
-0.16298689,
0.0150511805,
0.022112552,
-0.041557472,
0.009552465,
0.026244761,
0.0049462286,
-0.009395546,
-0.010866664,
-0.0006501528,
0.022831764,
0.004177978,
-0.043597426,
-0.013272761,
0.007152907,
-0.010330523,
-0.0012945846,
0.020726431,
0.026859362,
0.011906255,
0.006515422,
-0.01208279,
-0.005956397,
-0.000072636496,
-0.0047696945,
0.014671959,
0.017339587,
-0.0077871224,
0.00047566177,
-0.0050966097,
-0.024924023,
0.013678136,
0.03211616,
-0.0077413544,
0.015744241,
0.0064206165,
-0.0024028274,
-0.028167022,
-0.019693378,
0.0033672277,
0.024453266,
0.021837942,
-0.006469654,
0.022831764,
-0.004465663,
0.033031523,
0.017548814,
-0.0030370431,
0.009101322,
0.0016966905,
0.0076825097,
0.006436962,
-0.0049919966,
0.008022501,
0.02563016,
0.005573906,
0.018098032,
0.018438023,
-0.008630564,
-0.012769312,
-0.01184741,
-0.02960545,
0.039857514,
0.0045800833,
-0.0053744875,
-0.010068991,
-0.026127072,
0.018320333,
-0.030886957,
0.0014171778,
-0.01798034,
-0.005214299,
0.019536458,
-0.024060966,
0.023564056,
0.001462946,
-0.008898634,
0.0069306046,
0.02416558,
-0.0034097265,
-0.004524508,
-0.00023231418,
-0.01540425,
-0.021341031,
0.00320377,
0.0025875347,
0.0061786994,
0.02015106,
-0.0036418366,
0.008578258,
0.040694416,
-0.007623665,
-0.0030157936,
-0.015901161,
-0.0014335236,
-0.001516887,
0.022766382,
-0.019667225,
-0.01775804,
-0.005600059,
0.048618846,
-0.025525548,
-0.005063918,
-0.005508523,
0.046474278,
-0.0015642897,
-0.031514637,
0.00031424733,
0.051626466,
0.018398793,
-0.010866664,
0.004995266,
0.00021004309,
0.028742393,
0.0045179697,
0.037032966,
0.012442397,
0.007891735,
0.0046454663,
-0.015744241,
0.06344772,
0.015574245,
0.028010104,
0.012834695,
0.005694865,
-0.01849033,
-0.1225017,
-0.02798395,
0.010265141,
0.015038104,
-0.022334853,
0.03130541,
-0.01435812,
0.03156694,
-0.015129641,
0.024636338,
-0.038837537,
-0.00602178,
-0.0033083828,
-0.009892457,
-0.00017837316,
0.015626552,
0.015626552,
-0.0035045322,
-0.045846604,
0.034443796,
0.007002526,
-0.00837557,
-0.0053058355,
0.0021739868,
0.025551701,
0.00011370523,
-0.026100919,
-0.0061590844,
0.011337423,
-0.00046544566,
-0.010899357,
-0.01501195,
0.012847772,
0.0018650518,
-0.031514637,
-0.03590838,
-0.0019467806,
-0.014175047,
0.026493216,
-0.011625108,
0.006358503,
-0.0075452053,
0.023367906,
0.010762052,
-0.009245165,
-0.011213195,
-0.024688644,
-0.008460568,
0.012488165,
-0.0030615618,
-0.030520814,
-0.018751862,
-0.005956397,
0.016437301,
0.008525951,
0.0017359203,
0.0069894493,
0.007649818,
-0.014227354,
0.0036679897,
0.005616405,
-0.0067344555,
-0.017431123,
-0.0052175685,
0.0043283585,
-0.020307979,
-0.008565181,
-0.020791814,
0.012089328,
-0.017888805,
-0.0014694843,
-0.0040864414,
-0.007283673,
-0.011801642,
-0.026506294,
0.021785636,
-0.027957797,
-0.01586193,
0.030076208,
-0.03648375,
0.008604411,
-0.022295624,
0.009545927,
-0.010748975,
0.0020579319,
0.0011106947,
0.011729721,
-0.018817244,
-0.008127115,
-0.020543357,
-0.015338866,
0.03389458,
-0.0012030483,
-0.022740228,
-0.013691213,
0.0105920555,
-0.019889528,
-0.018346487,
0.010225911,
0.028820854,
-0.024322499,
-0.00493969,
-0.049194217,
0.000039944964,
0.00016008633,
-0.014645806,
0.0006517874,
-0.017522661,
0.016803447,
0.0035862608,
-0.001698325,
-0.009035939,
0.0014073704,
0.011291655,
0.0055837133,
-0.0012618931,
-0.017221898,
-0.011853949,
0.021903325,
-0.017091133,
0.025146326,
0.017901883,
-0.0050050733,
-0.0061263926,
0.008709024,
-0.0069436813,
-0.022975607,
-0.0040864414,
-0.0095655415,
0.0049364213,
-0.032194618,
0.0015160698,
-0.012475088,
-0.021837942,
-0.026493216,
-0.00032895853,
0.00038698598,
-0.014475809,
-0.0007629386,
0.04631736,
0.011906255,
0.022609463,
-0.0136258295,
-0.026990127,
0.005717749,
0.014462733,
-0.0038968304,
0.01864725,
-0.05183569,
-0.006185238,
-0.0014596769,
0.00864364,
0.0061656227,
0.009657078,
0.01374352,
-0.01455427,
0.002733012,
0.00011196849,
-0.019588765,
-0.0065873433,
-0.02369482,
-0.016528837,
0.012200479,
0.03894215,
-0.011703568,
-0.0056262123,
0.008676332,
-0.002361963,
-0.024492495,
-0.004998535,
0.017731886,
-0.025813233,
-0.03590838,
0.0018421677,
-0.0021200457,
0.0020088945,
0.0032805952,
-0.014345043,
-0.020111829,
0.006414078,
0.006557921,
0.037660643,
0.0035143394,
0.013357759,
0.0014490521,
0.010873203,
-0.0020039908,
0.00760405,
-0.0032707877,
-0.006342157,
0.008277495,
0.014789648,
-0.0002545853,
0.015875008,
0.026780901,
0.011049737,
-0.0013697752,
0.0125077795,
0.004527777,
0.017548814,
-0.006149277,
0.027356273,
0.00047607042,
0.009389007,
-0.0019941833,
-0.016908059,
-0.02400866,
0.020242596,
-0.03229923,
-0.011017046,
-0.029814675,
0.008218651,
-0.00093661237,
0.0051162243,
0.027879337,
-0.00660042,
-0.017169591,
-0.010415521,
0.0037987558,
-0.019431846,
-0.025943998,
0.0287947,
0.00022761479,
-0.0018536098,
-0.011932408,
0.010677054,
0.009526312,
0.0022491773,
0.024400959,
-0.018608019,
0.015286559,
-0.014135818,
0.019981064,
0.0025352282,
-0.008663256,
-0.0028654127,
-0.009049016,
0.0044133565,
0.0048710383,
0.025041712,
-0.022478696,
0.076105885,
0.01934031,
-0.044329714,
0.003981828,
-0.030154668,
0.048305005,
-0.001565107,
0.01157934,
-0.037032966,
-0.028611628,
0.02740858,
-0.035986837,
0.012808542,
-0.030991571,
-0.021131806,
0.04937729,
-0.010977816,
0.033946887,
-0.0117493365,
-0.01829418,
0.00011401171,
-0.021092575,
-0.011827796,
0.0011270405,
-0.056909416,
0.009748614,
0.022648692,
0.03308383,
0.0010175239,
-0.0145150395,
-0.010474366,
-0.04451279,
-0.03250846,
0.010160528,
0.016241152,
0.0010167066,
0.004397011,
-0.015090411,
0.04631736,
0.03133156,
0.024688644,
-0.009853227,
-0.010193219,
-0.05685711,
0.0034881863,
0.011631646,
-0.0074667456,
-0.024427112,
-0.0082251895
] |
Progress in aging research is now rapid, and surprisingly, studies in a single-celled eukaryote are a driving force. The genetic modulators of replicative life span in yeast are being identified, the molecular events that accompany aging are being discovered, and the extent to which longevity pathways are conserved between yeast and multicellular eukaryotes is being tested. In this review, we provide a brief retrospective view on the development of yeast as a model for aging and then turn to recent discoveries that have pushed aging research into novel directions and also linked aging in yeast to well-developed hypotheses in mammals. Although the question of what causes | [
-0.0053421245,
-0.02651449,
0.016594825,
-0.041407283,
-0.023097126,
0.0067981607,
-0.0084436815,
0.017033631,
-0.011242729,
-0.014666741,
-0.0007188764,
0.015078953,
0.0126854675,
0.0089955125,
-0.023748685,
-0.0056579313,
0.038428724,
-0.008284116,
-0.010458197,
0.01490609,
-0.011222783,
0.012386282,
0.008902432,
-0.02733891,
0.014613553,
0.037630893,
-0.0058873068,
-0.03361516,
0.006861322,
-0.0054152585,
-0.0021458254,
-0.021607846,
-0.013217353,
-0.012279905,
0.0022871073,
-0.013868913,
0.010165661,
-0.006096737,
0.0054119346,
-0.017578814,
0.0037730623,
0.01982603,
-0.015783701,
0.003031747,
-0.0077056903,
0.004670619,
0.0012466065,
-0.029705802,
0.019347332,
0.004039005,
0.010311929,
0.012625631,
-0.010032689,
0.011681534,
-0.01991911,
-0.030397253,
0.014387501,
0.015916672,
-0.017632002,
0.0017951133,
-0.013436756,
0.011023326,
-0.03542357,
0.032471605,
-0.012153583,
0.016980443,
0.0008809353,
0.002059394,
0.0071006706,
-0.010970137,
0.019560087,
0.008257521,
0.01958668,
0.011561859,
0.009693612,
-0.020783424,
-0.019294145,
0.0013039504,
0.0036101725,
0.019759543,
0.007340019,
-0.0062696,
-0.009999447,
0.0152252205,
-0.0013870575,
-0.0034705526,
-0.009514101,
-0.007506233,
0.00016860352,
0.0063128155,
0.0061964653,
0.024599701,
0.032897115,
0.034492772,
-0.01081722,
-0.008337304,
0.01444069,
0.031434428,
0.005049587,
-0.023974737,
-0.023602417,
-0.004717159,
0.015863484,
-0.024480028,
-0.030184498,
0.011109757,
0.013390216,
-0.010192255,
0.008556707,
-0.010990083,
-0.020730235,
0.03709901,
0.0011285944,
-0.023442851,
0.009161727,
-0.014746523,
0.012924816,
0.0027325614,
-0.015504461,
-0.014520473,
0.042444456,
0.0040988424,
0.025543798,
-0.021434983,
0.018722368,
-0.00021296194,
-0.007233642,
0.01100338,
0.007838662,
-0.0075461245,
0.0006469888,
-0.005907253,
0.010657654,
0.030104715,
-0.019506898,
0.004511053,
-0.022578537,
-0.011987369,
0.016461855,
-0.028987756,
0.010830517,
0.022831183,
-0.049465347,
0.0013829021,
-0.010936894,
0.025690068,
0.027219238,
0.021155743,
0.020650452,
0.013616268,
0.016554935,
0.0011543576,
0.046087872,
-0.009321292,
0.021767411,
0.03680647,
-0.0018948419,
0.0038761152,
-0.032338634,
-0.014241233,
-0.0050030476,
0.013802427,
0.014693336,
-0.001743587,
-0.02269821,
0.04861433,
0.01100338,
-0.0073001278,
0.003276082,
-0.0040888693,
-0.034466177,
0.016568232,
-0.013396865,
0.030530224,
-0.018961716,
0.020357916,
-0.009587235,
0.0022987423,
-0.020490887,
-0.01783146,
0.0052889357,
-0.0026694,
0.025596987,
0.015703918,
0.0032428391,
0.0052158018,
0.02079672,
-0.015690621,
0.009254807,
-0.0034705526,
-0.025849633,
0.012778548,
-0.018868636,
-0.0051592886,
-0.6437941,
-0.02882819,
-0.011787911,
-0.0071937507,
0.0037896838,
0.013549781,
0.003640091,
0.01378913,
-0.020344619,
0.0094742095,
-0.0031597319,
0.020078676,
0.013543133,
0.0024317137,
-0.024546513,
-0.02530445,
0.0051426673,
-0.030822761,
0.015956564,
0.012100394,
-0.043614607,
0.006216411,
0.0078054187,
0.017578814,
0.0025430773,
0.020158459,
0.020690344,
-0.020836612,
-0.0006332761,
0.042125326,
-0.022139732,
0.013243947,
-0.020145161,
-0.014015181,
0.047710124,
0.015318301,
0.008111253,
0.004015735,
0.011482077,
0.028934568,
-0.023735387,
-0.0055781486,
0.014307719,
-0.012213419,
-0.03882764,
0.0040589506,
0.017100116,
0.017592112,
0.0034439582,
-0.01100338,
0.012313148,
0.017073523,
-0.013037842,
-0.009347887,
0.01861599,
0.03784365,
0.024745971,
-0.024027925,
-0.00033222063,
0.0030799492,
-0.008244224,
0.020264836,
-0.015677324,
0.003547011,
-0.04481135,
0.024892239,
-0.026501192,
0.016102832,
0.02567677,
-0.015570946,
0.008616544,
0.008463627,
-0.028562248,
-0.0022322568,
0.009234861,
0.026408112,
-0.006505624,
0.008689678,
-0.030290876,
0.012007314,
0.004095518,
-0.014427393,
-0.027764421,
0.013842318,
0.016794283,
-0.020304726,
-0.004760375,
0.0061864927,
-0.013110976,
0.017698487,
0.009487507,
-0.0004836833,
-0.021740817,
-0.03162059,
-0.020318024,
0.013137571,
-0.010803923,
-0.011043271,
0.0008227603,
-0.013922102,
-0.000573439,
-0.009015459,
0.010006095,
0.0021707574,
-0.0021242176,
0.019985596,
-0.019560087,
0.0038328995,
0.05483739,
-0.019812733,
0.022777993,
0.015198627,
-0.013855616,
0.0035436868,
-0.012645576,
-0.026594272,
0.025370935,
0.0070075905,
0.016355477,
-0.027870797,
0.015145438,
-0.0008510167,
-0.0036334423,
-0.0035902266,
-0.0029054242,
0.0017103441,
0.0045708907,
-0.027285723,
-0.022299297,
-0.00090088096,
0.014134856,
-0.025796443,
0.00854341,
-0.0213552,
0.015504461,
0.009627126,
0.012924816,
-0.028562248,
0.01815059,
-0.010358469,
-0.02571666,
0.000555571,
-0.005837443,
0.003935952,
-0.0054385285,
-0.0056812013,
-0.011023326,
-0.021062663,
0.004474486,
0.0033525403,
0.0046539977,
0.017392654,
-0.020783424,
0.010079229,
0.00585074,
-0.0042284895,
-0.007293479,
-0.041061558,
-0.007679096,
-0.001180952,
0.0008190205,
0.017951133,
-0.02580974,
0.013297136,
-0.012818439,
0.00048617655,
-0.009261455,
0.0036367667,
-0.016049644,
-0.002563023,
-0.0049166162,
-0.020956287,
-0.01926755,
0.01675439,
0.008935675,
0.01295141,
0.012240014,
0.007433099,
-0.009467561,
-0.010704194,
0.0039459253,
-0.012579091,
-0.0015948253,
-0.0120738,
0.008177739,
0.010225497,
0.02962602,
0.0061000613,
0.0055449056,
0.03922655,
0.01922766,
0.031700373,
0.007951687,
0.00891573,
0.0026694,
-0.030929139,
-0.010857112,
-0.002187379,
0.019599978,
0.02850906,
0.001099507,
-0.03611502,
0.0037198737,
-0.03515763,
0.008337304,
-0.010045987,
0.003699928,
-0.004723808,
0.013317082,
0.022538645,
0.012718711,
0.0032112584,
-0.027764421,
0.009633775,
0.022325892,
0.014360907,
-0.009866475,
-0.0006598704,
-0.025650175,
0.010345172,
-0.010019392,
-0.008895784,
0.019054797,
-0.018469721,
-0.011681534,
0.050023824,
-0.0126854675,
0.04699208,
-0.008197685,
-0.0066452436,
-0.018895231,
0.012240014,
-0.0016995402,
0.023429554,
0.013682753,
0.021474876,
0.012067151,
0.0019496926,
0.013396865,
0.0190415,
-0.01281179,
-0.0089955125,
0.008244224,
0.017379357,
0.0053388,
0.022950856,
0.038375534,
0.007433099,
-0.02390825,
-0.011874342,
-0.009175024,
0.015185329,
-0.017445842,
-0.03068979,
-0.015251815,
-0.0124926595,
0.0003155992,
-0.008051416,
0.022086542,
0.024732674,
0.014586958,
-0.013097679,
-0.022871073,
-0.018921824,
-0.0039625466,
0.008556707,
0.015158735,
-0.010930246,
-0.0008090476,
-0.004085545,
-0.016834173,
0.008576653,
0.014055072,
-0.018443128,
0.008330655,
0.0083971415,
0.020411104,
0.01898831,
0.009553992,
-0.014932684,
-0.030237688,
-0.012426173,
0.018190483,
0.026953295,
0.005126046,
-0.03834894,
-0.008942324,
-0.014507175,
-0.0117746135,
-0.014467284,
0.0077056903,
0.011395645,
-0.008789407,
-0.013722644,
-0.0029652612,
0.00046498422,
0.016554935,
-0.040662643,
0.007466342,
0.0012856668,
0.013563079,
0.013829022,
0.011315863,
-0.011089811,
0.032391824,
-0.0072070477,
-0.0028422629,
0.0010837166,
-0.0010139067,
-0.023535931,
-0.02757826,
-0.0048866975,
0.009321292,
-0.012652225,
0.0022555266,
0.021022772,
-0.0093545355,
-0.015145438,
0.021302013,
0.0030982327,
0.020823315,
-0.0320461,
-0.023668902,
0.007984931,
0.042045545,
0.040928584,
-0.0036500639,
0.016874066,
0.004810239,
0.0014460635,
0.0073200734,
-0.019001607,
0.029306889,
-0.009081944,
-0.020078676,
-0.016142722,
0.04438584,
-0.017578814,
0.02084991,
0.023788577,
0.0046373764,
-0.021647738,
-0.01332373,
-0.012652225,
0.02094299,
-0.040077567,
0.024626296,
0.053374704,
0.041726414,
0.00071222783,
0.011515319,
0.026501192,
-0.01258574,
0.0058241454,
-0.01188764,
0.016780986,
-0.0036267939,
0.024878941,
-0.015211924,
0.0037963323,
0.01773838,
0.018230373,
-0.006146601,
0.016608123,
0.011807857,
0.007094022,
0.013071084,
-0.0041387337,
-0.0015532717,
-0.0071538594,
0.013110976,
0.010172309,
-0.023017343,
-0.030157905,
0.028216522,
-0.022910966,
-0.018163888,
-0.011295917,
0.016967146,
0.0062430054,
-0.0046539977,
-0.009440967,
-0.0068048094,
-0.013709348,
-0.0020211646,
-0.022166327,
0.030423848,
0.0035802538,
0.012871628,
0.0181107,
-0.0114621315,
-0.0027990472,
-0.031859938,
-0.006429165,
-0.00022044158,
-0.012732008,
-0.021940274,
0.00033575267,
0.004168652,
0.020185053,
0.01852291,
-0.04201895,
-0.018323453,
0.004740429,
0.0044977563,
0.007466342,
-0.02595601,
-0.03497147,
-0.02094299,
-0.008490222,
0.011043271,
-0.021607846,
-0.013483296,
-0.0038328995,
0.00496648,
-0.0046174303,
0.0014203003,
-0.019839328,
-0.021514766,
0.002950302,
0.034014072,
0.022525348,
-0.018350048,
-0.024799159,
-0.0030383957,
-0.012519253,
-0.01063106,
-0.020118566,
-0.020770127,
-0.02994515,
-0.0049531832,
0.0026178737,
-0.008510167,
-0.001077068,
0.0070607793,
-0.00807801,
0.01913458,
0.00594382,
0.006565461,
0.018855339,
0.0030034906,
0.009514101,
-0.0066053523,
-0.008649787,
-0.008550058,
-0.008177739,
0.03180675,
0.0063394094,
-0.011861045,
0.007459693,
-0.0152252205,
-0.017711785,
-0.013855616,
0.0095938835,
-0.0026876836,
0.040662643,
-0.006435814,
-0.037870243,
-0.020583967,
0.0027192642,
0.000041449664,
0.023097126,
0.00979334,
-0.0106975455,
-0.009341238,
-0.014826307,
-0.012193474,
-0.008483573,
0.021780709,
-0.043401852,
-0.0048634275,
0.01917447,
0.02112915,
0.011395645,
-0.0023585795,
0.003699928,
-0.0031115299,
-0.0132372985,
-0.010757383,
-0.01932074,
0.015398083,
-0.0190415,
0.04169982,
0.01193418,
0.011036623,
-0.020251539,
-0.00037543633,
0.023469444,
0.015717214,
-0.0064324895,
-0.023695497,
0.016674608,
0.0020095296,
0.026527787,
0.0039259796,
0.029360076,
-0.0013995236,
-0.013363622,
0.01555765,
0.029572831,
-0.00886919,
-0.02340296,
-0.027033078,
-0.052763037,
-0.024081113,
0.013569728,
-0.023163611,
-0.010877057,
-0.006708405,
0.003932628,
0.006791512,
0.030397253,
-0.010976786,
0.0045974846,
0.015358192,
-0.02001219,
0.040503077,
-0.011548563,
0.016102832,
-0.020650452,
0.004132085,
-0.017206494,
-0.024307165,
0.0054485016,
-0.0048501305,
-0.003252812,
0.006143277,
0.0017369384,
0.008363899,
0.00826417,
-0.027445288,
-0.030184498,
-0.015863484,
-0.02265832,
0.020145161,
-0.0067482963,
-0.031221675,
-0.030344065,
-0.009248158,
-0.0050296416,
-0.012525902,
0.028110145,
-0.0032727576,
-0.027126158,
0.021621143,
0.008576653,
0.011708128,
-0.009394427,
0.042231705,
0.018762259,
0.0047504017,
-0.020065378,
-0.016169317,
-0.011588454,
0.010557926,
0.014387501,
0.0008460303,
-0.004730456,
-0.006332761,
-0.0005318854,
-0.007665799,
-0.01555765,
-0.037444737,
0.023389662,
0.0070474823,
0.008782758,
0.008071361,
-0.014959278,
0.008410439,
0.0025829687,
-0.00075004157,
-0.009161727,
0.015570946,
-0.015597541,
0.009294698,
0.026275141,
-0.000098533856,
0.007074076,
0.0063593555,
-0.022618428,
0.012732008,
-0.021182338,
-0.0067615937,
-0.012060503,
-0.014826307,
0.01639537,
-0.022259405,
0.00877611,
0.0011360741,
0.013722644,
0.007679096,
-0.0069942935,
-0.004494432,
0.043720983,
-0.011488725,
0.00040493935,
-0.0070607793,
0.011555212,
-0.0021026097,
-0.020690344,
-0.0036068482,
0.009321292,
-0.0020161783,
-0.009713558,
0.026328329,
0.0053321514,
0.012093745,
-0.018256968,
-0.009234861,
-0.007559422,
-0.017698487,
-0.0146002555,
0.0057643084,
-0.024692781,
0.014693336,
0.0030799492,
0.020610562,
0.03329603,
-0.016049644,
-0.006961051,
-0.00280902,
0.022259405,
-0.0152252205,
0.017538922,
-0.00005303272,
-0.03050363,
-0.029971745,
0.01815059,
-0.019839328,
-0.019334035,
-0.007492936,
-0.020052081,
-0.03765749,
0.0075461245,
-0.012240014,
0.03640756,
0.019852623,
-0.008722921,
-0.0014950967,
0.015983157,
0.0020062055,
-0.010032689,
-0.031434428,
0.0095938835,
-0.0028755057,
0.020238241,
0.022086542,
-0.028562248,
-0.0016180952,
0.03571611,
-0.019480305,
0.0020494212,
-0.018030917,
-0.0027608178,
-0.02265832,
0.001440246,
0.015344895,
-0.0037597653,
0.014134856,
-0.030955732,
-0.014028478,
0.031301457,
0.004015735,
-0.01193418,
-0.03935952,
-0.009254807,
0.016780986,
0.015890077,
0.011688182,
0.016594825,
0.0016546623,
0.008589949,
-0.035822485,
-0.015717214,
-0.006309491,
0.035370383,
0.0138822105,
0.006262951,
-0.016461855,
-0.016408665,
-0.051380135,
-0.008882487,
0.025344342,
0.011608399,
0.005328827,
0.016461855,
-0.003427337,
0.020623857,
-0.0020111918,
0.017698487,
-0.020065378,
-0.02850906,
0.023243394,
-0.014214639,
0.01963987,
-0.0025198073,
-0.024067815,
0.0013621254,
0.025650175,
-0.012898222,
-0.021341903,
-0.0040090866,
0.020291429,
0.01815059,
-0.009214915,
0.0067482963,
0.01555765,
0.016448557,
0.031753562,
-0.013077733,
-0.022618428,
0.0075993133,
-0.030104715,
-0.010391712,
-0.0121336365,
-0.015012466,
0.008536762,
0.027232535,
-0.009427669,
-0.04382736,
0.013110976,
-0.021514766,
0.019214362,
0.01425453,
0.038003214,
0.030556818,
-0.007094022,
-0.022871073,
-0.0048634275,
-0.0031979613,
-0.024533216,
-0.0011551887,
-0.00032120894,
-0.0051659374,
-0.0035802538,
-0.015637431,
-0.02057067,
-0.01179456,
-0.0035769297,
0.004740429,
-0.021235526,
-0.02642141,
0.0208898,
0.009061998,
-0.0026128872,
-0.013908804,
0.015198627,
-0.010910301,
-0.02795058,
-0.0115352655,
-0.013842318,
0.00087013136,
0.02455981,
-0.012060503,
-0.012758602,
-0.009421021,
-0.004457865,
0.007512882,
-0.027764421,
-0.0066219736,
0.18637265,
-0.02279129,
0.008044767,
0.018004322,
0.015198627,
-0.01630229,
0.015437975,
-0.008556707,
-0.022126434,
0.008151145,
0.007572719,
0.009766746,
0.0047271317,
-0.0012698765,
0.018549506,
-0.03566292,
-0.009507452,
0.01434761,
-0.005957117,
-0.010637709,
-0.0026594272,
-0.01926755,
-0.013376919,
0.004427946,
0.035902265,
-0.0025480636,
-0.022897668,
-0.003919331,
-0.00022729792,
-0.0060601695,
-0.011169595,
-0.028083552,
-0.0042118677,
0.0011269323,
-0.008051416,
-0.019506898,
0.011069866,
-0.033907697,
0.030530224,
-0.0018117347,
0.01652834,
0.017272979,
0.02381517,
0.0071538594,
0.0162491,
0.008909081,
-0.005418583,
-0.006784864,
0.005395313,
-0.018177185,
-0.05377362,
-0.000099261044,
-0.0022172974,
0.013337027,
0.020211646,
-0.008889136,
0.021022772,
-0.007825364,
0.0043348665,
0.022645023,
-0.01954679,
-0.012785196,
-0.034705523,
-0.011023326,
-0.016648015,
0.024759267,
-0.028535655,
-0.0039492496,
0.0072535877,
-0.012486011,
-0.008317359,
-0.018363345,
-0.031966314,
0.008151145,
0.001333869,
0.010411657,
0.034226827,
0.02075683,
0.019533493,
-0.0056978227,
-0.024852347,
0.014374204,
-0.021567954,
-0.0039027093,
-0.003256136,
-0.044651784,
0.02349604,
0.0034007425,
-0.0324982,
-0.011767966,
-0.000731758,
0.0028056956,
0.0049099675,
-0.013071084,
0.020371212,
-0.011575157,
-0.00020818328,
0.012525902,
0.010318577,
-0.0045243506,
-0.024945427,
0.051140785,
0.003394094,
0.0065155965,
-0.0036434152,
0.017911242,
-0.022591835,
0.022259405,
-0.009387778,
-0.034359798,
-0.0039459253,
-0.021315308,
0.020504184,
-0.014972575,
-0.021474876,
0.015823592,
0.025477313,
-0.023668902,
0.0636135,
-0.0135231875,
-0.021700926,
-0.034678932,
-0.015690621,
0.027498478,
-0.010890354,
-0.021674331,
-0.018030917,
0.0071006706,
-0.024852347,
-0.031647183,
-0.0043348665,
-0.0026511166,
-0.029705802,
0.009022106,
0.012140285,
-0.004836833,
-0.01039836,
-0.006146601,
-0.0039758435,
0.0138822105,
-0.03965206,
0.01662142,
0.026195358,
0.0125657935,
-0.020876504,
-0.014773118,
0.0109834345,
0.031195082,
-0.00886919,
-0.0061266553,
0.0066219736,
-0.0324982,
0.0057177683,
0.007393208,
0.0110565685,
-0.016794283,
-0.016102832,
-0.019693058,
-0.022113137,
0.017339466,
-0.04513048,
0.02888138,
0.01922766,
0.0035503353,
0.014188044,
0.0038362239,
-0.16722478,
0.0018167212,
0.011668237,
-0.019786138,
0.023349771,
0.011502023,
0.020038784,
0.00042675497,
-0.011521968,
0.024586404,
0.006625298,
0.0061266553,
-0.04786969,
-0.023163611,
-0.0025829687,
0.016794283,
0.0046639703,
0.0320461,
0.02409441,
-0.010730789,
0.022964153,
-0.022711508,
0.0123729855,
-0.0121336365,
-0.0013829021,
0.019959,
0.02163444,
-0.008164441,
-0.0014817996,
-0.03398748,
-0.018084105,
0.009048701,
0.024639593,
-0.035636324,
-0.032710955,
0.0035170924,
-0.01634218,
-0.0030284228,
-0.006861322,
0.01053798,
0.027126158,
0.031833343,
0.026567677,
0.007140562,
-0.007499585,
0.04015735,
-0.013543133,
-0.012146934,
0.003138124,
-0.014746523,
0.024573108,
0.012665522,
-0.005923874,
0.012878276,
0.00564131,
-0.009487507,
0.015823592,
0.000684387,
0.004906643,
-0.013563079,
-0.009766746,
-0.0007587678,
0.052098177,
-0.002774115,
0.015451272,
-0.026634164,
-0.029067539,
0.011089811,
-0.021022772,
-0.000555571,
-0.004002438,
0.0008240069,
0.019427115,
-0.0015358193,
0.026541084,
0.02079672,
-0.0029685856,
0.0006050197,
-0.012778548,
0.006422517,
-0.019972298,
0.01630229,
-0.02057067,
-0.015012466,
-0.011109757,
0.017618705,
0.0056679044,
0.02390825,
-0.010411657,
0.0052822875,
0.018217076,
-0.014387501,
-0.035131034,
-0.01490609,
0.0067383237,
0.002350269,
-0.010099174,
0.005777606,
0.0011069865,
0.016262397,
0.012446119,
-0.0054019615,
-0.006156574,
0.005368719,
0.045103885,
-0.016648015,
-0.024347056,
0.00068646466,
0.047763314,
-0.0067017567,
-0.009959555,
0.015531055,
0.007758879,
0.029227106,
-0.01276525,
0.02901435,
0.0036001995,
-0.0032212313,
0.014626849,
-0.004890022,
0.07191091,
-0.00046165995,
-0.014759821,
0.025424125,
0.003779711,
-0.024799159,
-0.1211635,
-0.009361184,
-0.025158182,
0.01337027,
-0.005481744,
0.009534047,
0.0015698931,
0.041221123,
-0.00821763,
0.025783148,
-0.0076923934,
-0.010285335,
-0.0013172475,
-0.013722644,
-0.0061864927,
-0.024546513,
0.0118942885,
-0.01471993,
-0.028854785,
0.026620867,
-0.008536762,
0.0055548786,
-0.0012856668,
0.00022979113,
0.008576653,
0.023269989,
-0.015929969,
0.026594272,
0.0020909747,
0.0117746135,
-0.0035736053,
-0.0044312705,
-0.0031032192,
-0.019068094,
-0.00036899553,
-0.019945703,
0.0060801157,
-0.017033631,
0.03236523,
-0.042231705,
-0.0048734006,
0.0013579701,
0.0273921,
0.0084436815,
0.013190759,
-0.021089258,
0.011249377,
0.034333207,
0.005860713,
0.0110565685,
-0.024240678,
0.013130922,
-0.044970915,
-0.018748961,
0.00821763,
-0.032338634,
0.008816001,
-0.0181107,
0.0034173639,
0.007359965,
-0.007679096,
0.0026959942,
-0.004860103,
-0.015437975,
0.012040556,
-0.03542357,
-0.012020611,
-0.025357638,
0.005352097,
-0.038375534,
0.011322511,
0.0034738767,
-0.008164441,
0.0068214308,
-0.028402682,
0.0004645687,
-0.004248435,
-0.021621143,
0.008064713,
0.006867971,
-0.0031480968,
-0.01258574,
0.010198903,
-0.015211924,
0.028243117,
-0.0055149873,
0.0027209264,
-0.008536762,
0.013157516,
-0.018655881,
-0.010438252,
0.024745971,
-0.006169871,
-0.015185329,
-0.016634718,
-0.0017386005,
0.0015474542,
-0.011455483,
0.022113137,
0.0049930746,
-0.018536208,
0.0043847305,
-0.042604025,
0.0038927365,
0.0017352763,
-0.018935122,
-0.003979168,
0.001205884,
0.01926755,
-0.009746801,
-0.013549781,
0.043056127,
-0.016009752,
0.019599978,
-0.0024400244,
-0.015757106,
-0.027764421,
-0.020264836,
0.027737826,
-0.015624135,
0.02098288,
0.016408665,
0.027737826,
0.017113414,
0.01355643,
0.024772564,
-0.016382072,
-0.003335919,
-0.0063128155,
-0.0104449,
-0.010338523,
-0.009627126,
0.017286276,
-0.03473212,
0.0047337804,
0.0042417864,
-0.014028478,
-0.011787911,
0.00055515545,
0.019879218,
0.022990748,
0.03241842,
-0.01611613,
-0.022910966,
0.010258741,
-0.019786138,
-0.01922766,
0.0021840546,
-0.031514212,
0.025144884,
0.0027940606,
0.007074076,
0.043534823,
0.00058216526,
-0.013948696,
-0.02571666,
0.009367832,
0.0020394481,
-0.009773395,
-0.0019696383,
-0.012732008,
-0.0023934846,
0.01369605,
0.008716273,
0.014055072,
0.0023984709,
-0.015850186,
-0.022392377,
-0.019054797,
0.0036334423,
0.009766746,
-0.039519086,
0.0045908364,
0.007512882,
0.009853178,
0.014653444,
0.0060103056,
-0.0050296416,
-0.028854785,
0.0099795,
0.00042052192,
0.02098288,
0.023256691,
0.007492936,
-0.016634718,
0.022365782,
0.0320461,
0.014028478,
0.026341626,
0.034545958,
0.0047736717,
-0.01350989,
0.0031680427,
0.014493878,
0.016980443,
0.006415868,
0.020238241,
0.018230373,
-0.016355477,
0.0077056903,
-0.0016222507,
-0.011688182,
-0.0043016234,
0.01898831,
0.015850186,
-0.025636878,
-0.0045143776,
0.018256968,
-0.027365506,
-0.01281179,
-0.011089811,
0.0044412436,
0.027471883,
-0.0051892074,
-0.009647072,
0.009261455,
-0.015384787,
0.016927253,
-0.019493602,
-0.001697878,
0.0016754392,
0.021248823,
0.007506233,
0.0021690952,
0.001298964,
-0.0015856834,
0.024785861,
0.0043714335,
0.023482742,
0.0051459917,
0.0037198737,
-0.015610837,
0.031966314,
-0.010245443,
-0.022418972,
-0.023269989,
-0.0027092914,
-0.020956287,
0.004108815,
0.00561804,
-0.03709901,
0.068932354,
0.032099288,
-0.027365506,
0.023057234,
-0.0024034574,
0.008523464,
0.018935122,
0.009467561,
-0.017379357,
-0.033349216,
0.023376364,
-0.015770404,
0.009042053,
-0.006472381,
0.009487507,
0.0028522357,
0.017432546,
0.0069012134,
-0.0026278466,
-0.025557095,
0.012645576,
-0.009407723,
0.019759543,
0.009035404,
0.0055781486,
-0.0028140065,
0.040130757,
-0.008709624,
0.010212201,
-0.01796443,
0.012459417,
0.008024822,
-0.022432268,
0.0021109204,
-0.0031447727,
-0.0021142447,
0.005973738,
-0.028854785,
0.014866198,
-0.0030733005,
-0.0010795612,
-0.005418583,
-0.009367832,
0.0049465345,
-0.013815724,
0.0023602417,
0.008789407,
-0.020703642,
-0.012412877
] |
BACKGROUND The prevalence of metabolic syndrome (obesity, glucose intolerance, low serum high-density lipoprotein cholesterol [HDL-C], high serum triglycerides, hypertension) is high and increasing in parallel with an increasing breast cancer incidence worldwide. HDL-C represents an important aspect of the syndrome, yet its role in breast cancer is still undefined. METHODS In two population-based screening surveys during 1977-1983 and 1985-1987, serum HDL-C was assayed enzymatically among 38,823 Norwegian women aged 17-54 years at entry. Height, weight, blood pressure, serum lipids, fat | [
-0.027407158,
-0.008372965,
0.004228737,
-0.04303496,
-0.0022151303,
-0.0024784107,
-0.012370925,
0.011649342,
-0.019710273,
-0.014938721,
-0.0007223958,
0.008574489,
-0.001839712,
0.0033608873,
-0.024403812,
0.021543482,
0.04753348,
-0.009003538,
0.020607375,
0.0074823624,
-0.0364562,
-0.017409006,
0.011064275,
-0.0033348843,
0.0050380807,
-0.0040499666,
0.02543093,
-0.03791237,
-0.0017210734,
-0.014808707,
0.017565025,
0.007774896,
-0.030423507,
0.018631147,
-0.0054931333,
0.0015764317,
0.011421816,
-0.010089163,
0.014548677,
-0.021855518,
0.00858749,
0.0011368186,
0.0030130972,
0.0026799338,
-0.014808707,
-0.002965967,
0.013261529,
-0.019320227,
-0.013859597,
0.022973647,
0.00633498,
0.00911405,
-0.0061627105,
-0.020022308,
-0.01874816,
0.008138938,
-0.01847513,
0.025976993,
0.021920526,
-0.023883753,
-0.004495268,
-0.015783818,
-0.018124089,
-0.000022257449,
0.0032438738,
-0.0026506805,
0.0031853672,
0.03141162,
-0.010492209,
0.038380425,
0.016316881,
0.0390305,
-0.021751506,
0.0009791753,
0.019255219,
-0.008704503,
-0.028421275,
-0.019333228,
-0.0061854627,
-0.003121985,
0.028421275,
-0.0036729234,
0.00806743,
0.016290877,
0.01813709,
0.0069362996,
-0.0016016221,
0.016810937,
0.0074173547,
-0.018696155,
0.013456551,
-0.00079999847,
0.0023353943,
-0.0030260987,
-0.009224563,
0.0056328992,
0.010719735,
0.026653072,
0.0002492631,
-0.008756509,
-0.00063301047,
0.0070338105,
-0.010641727,
-0.009640611,
-0.012357924,
-0.011675346,
-0.012416431,
0.010667729,
0.009042542,
-0.011116281,
0.0005761289,
0.037106276,
-0.0022411332,
-0.020347346,
0.0442571,
-0.019801281,
0.0007991859,
0.00971212,
0.004755298,
-0.0045927796,
0.009322074,
0.024910871,
0.028005227,
-0.0033608873,
0.0056328992,
-0.011233294,
-0.031879675,
-0.022141552,
0.000021952725,
0.00442376,
0.023350691,
-0.016303878,
-0.0008215322,
-0.0047682994,
-0.0225576,
-0.0003697301,
-0.017773049,
-0.004449763,
-0.021283453,
-0.027641186,
-0.009952647,
0.027901215,
-0.0052428544,
-0.0033381348,
-0.011746854,
0.031177593,
0.027095122,
0.02205054,
-0.01813709,
-0.021946529,
-0.0040759696,
0.0007959355,
0.028057234,
-0.0026360538,
0.0019941048,
0.009296072,
-0.007235334,
0.012845481,
-0.029721426,
-0.013703579,
-0.004875562,
-0.0084899785,
0.019216215,
0.0048625604,
0.018059082,
0.016394889,
0.01838412,
-0.0067802817,
-0.008210447,
-0.0033933911,
0.00023565216,
0.04363303,
-0.031723656,
0.021361463,
-0.0042709922,
0.028395273,
-0.0146786915,
0.006152959,
-0.0074173547,
-0.04501119,
-0.040746696,
0.048625603,
0.030709539,
0.004189733,
-0.018930182,
0.014847712,
0.020802397,
-0.009471592,
0.018566139,
-0.05403423,
-0.011863868,
0.032789778,
-0.0031691152,
-0.031983685,
-0.6469546,
-0.014756701,
-0.0069883056,
0.0030293493,
0.011896371,
0.0154717835,
0.024429815,
0.0039232024,
-0.008600491,
0.0066080117,
-0.0011888245,
0.012981996,
-0.011200791,
-0.01640789,
-0.0005854737,
-0.028005227,
-0.018163094,
-0.0062277177,
0.0065105003,
-0.019099202,
-0.038380425,
0.010115166,
-0.015107742,
0.019554254,
0.011571334,
0.01500373,
0.017122973,
-0.019229217,
0.00373143,
0.0373143,
0.005311112,
0.028005227,
-0.002454033,
0.01969727,
0.04397107,
-0.019008191,
0.005850674,
0.026354037,
0.023636725,
0.035520095,
-0.011148785,
-0.0069623026,
0.012396929,
0.01778605,
-0.012188905,
0.043503013,
0.011688347,
0.01170785,
0.011324305,
0.010225679,
0.0044302605,
-0.0011522578,
-0.020516364,
-0.016849943,
0.010531214,
-0.017161978,
0.0147437,
-0.04579128,
-0.0014683567,
0.025690962,
-0.0016999459,
0.020867405,
-0.009153055,
0.000297003,
-0.020880407,
0.033257835,
-0.018072084,
0.0053923717,
-0.010661229,
-0.0015821198,
0.004745547,
0.02803123,
-0.000053935903,
0.00858749,
0.039082505,
0.0055451393,
0.025794974,
0.015341768,
0.0004351439,
0.0025921739,
0.03494803,
0.005431376,
-0.016342884,
-0.0032666265,
-0.0064097387,
-0.016927952,
0.0065722577,
0.018566139,
-0.0093350755,
0.013469553,
0.031073581,
-0.0019843536,
0.00030492578,
-0.030397503,
-0.011460821,
0.020425355,
-0.02933138,
0.014977726,
0.007781397,
-0.015146745,
-0.037860364,
-0.000020289448,
-0.018072084,
0.005590644,
0.029591411,
-0.014093624,
-0.027355153,
0.004963322,
0.0320877,
-0.02758918,
0.010791244,
-0.0029464646,
-0.014873714,
-0.0021143686,
-0.00798292,
-0.013287531,
0.00251579,
-0.00093935826,
-0.0036924256,
-0.015666805,
0.011493324,
0.011200791,
0.016719928,
-0.0025547945,
0.0058701765,
0.018878175,
0.000500964,
-0.013664575,
0.0052948603,
-0.016290877,
-0.0061334567,
0.009868138,
0.012338422,
-0.0146266855,
0.021998536,
-0.009887639,
0.011467322,
0.008964533,
-0.002671808,
-0.044465125,
0.0013229025,
-0.013690578,
-0.0035266564,
0.007397853,
-0.010992767,
-0.009081547,
-0.005850674,
0.002376024,
0.0032910043,
0.011649342,
-0.022960646,
-0.028447278,
0.0049308185,
0.010615723,
0.0033348843,
-0.008106435,
0.02628903,
-0.005665403,
0.01587483,
0.003089481,
0.003763934,
-0.0064422423,
-0.020165324,
-0.012435934,
0.011785858,
-0.012325421,
0.012565948,
0.022024538,
-0.015601798,
-0.031125588,
-0.016290877,
-0.028135242,
-0.010193175,
0.004989325,
0.0017210734,
0.015393774,
-0.019775279,
-0.01180536,
-0.019060196,
-0.012890986,
0.0303715,
-0.020737391,
-0.023155669,
-0.0056621525,
0.056374498,
0.00076140027,
0.028759316,
-0.0012075142,
0.0025434182,
0.0041669803,
-0.026562061,
0.014158632,
0.0057271603,
-0.017396005,
0.008301456,
-0.015484785,
-0.0012660209,
-0.0017584526,
0.020100316,
0.009913643,
0.027979225,
-0.015510788,
0.024195788,
0.00006978148,
0.014652689,
-0.018540137,
0.014717696,
0.01067423,
0.004436761,
0.007826902,
0.014821708,
0.008268953,
0.004973073,
-0.002325643,
-0.015978841,
-0.003591664,
0.026653072,
-0.022076545,
-0.001483796,
-0.017981073,
-0.012416431,
-0.010089163,
0.023961762,
-0.016342884,
0.00031609894,
0.016693924,
0.032633763,
0.010056659,
-0.016069852,
0.0005732848,
-0.0011871994,
-0.008619994,
-0.0103166895,
0.018111087,
0.004007712,
0.0012229534,
0.014119627,
-0.015770817,
0.008463976,
0.00468379,
0.0028700808,
0.0029870942,
0.025560945,
-0.014977726,
0.0012627705,
-0.01605685,
0.017435009,
0.021244448,
-0.008743508,
-0.012936491,
0.006191964,
0.0007585562,
-0.0130145,
0.019333228,
0.0034681498,
-0.002619802,
0.0018332113,
0.00937408,
0.030215483,
0.016888946,
0.04467315,
-0.0047748005,
0.0070923176,
-0.0037346804,
-0.0041084737,
0.0058604255,
0.025456933,
0.002429655,
0.0083859665,
-0.005259106,
-0.022466589,
-0.0015496161,
0.010141169,
-0.057830665,
0.013651573,
0.00555164,
0.021192443,
0.0021062428,
0.02541793,
0.0242998,
-0.0073003415,
-0.011220293,
0.008893025,
0.025365924,
-0.009666614,
-0.03403792,
-0.008379466,
-0.006273223,
0.010992767,
0.013125013,
0.031255603,
-0.0029220867,
0.013261529,
-0.0074953637,
-0.02368873,
-0.014067621,
0.00399146,
-0.0066827703,
0.007527868,
0.01457468,
0.00299197,
-0.0047487975,
0.0077943983,
-0.0199573,
0.029383387,
-0.0009385457,
-0.01153883,
0.00045220836,
-0.0041149743,
-0.008528983,
0.00022833882,
-0.018787166,
-0.0011693223,
0.0011416941,
0.021569487,
0.028343266,
-0.0014740449,
0.0047195437,
0.002881457,
-0.006819286,
-0.0074693607,
-0.02836927,
-0.020178325,
-0.0049828244,
0.031281605,
0.012598452,
0.0030683537,
0.0030065966,
0.009465091,
0.014847712,
0.0028131993,
-0.017734043,
-0.0002827826,
0.024585834,
0.0044562635,
-0.008515982,
0.0022443838,
0.009276569,
-0.008977535,
0.0056198975,
0.0067802817,
-0.025274914,
0.012429433,
-0.00806743,
-0.010531214,
-0.0055678915,
0.032607757,
0.04537523,
0.024676844,
-0.016680922,
-0.001270084,
0.038146395,
0.0034226445,
-0.009250566,
-0.022011537,
0.014886715,
-0.017903063,
0.020529367,
-0.0039719576,
-0.0046285335,
0.015016731,
-0.0074433577,
0.012175904,
-0.004622033,
0.022232562,
0.008450974,
0.018605145,
0.029253371,
0.015237756,
0.0020981168,
0.01180536,
0.026523057,
0.026835093,
-0.012013385,
0.033439856,
0.008054429,
-0.020490361,
-0.019021193,
0.0011116281,
-0.030683536,
0.007183328,
-0.02289564,
0.0036761737,
0.0038906985,
-0.0051518437,
-0.0042449892,
0.018358115,
-0.001162009,
-0.0033218828,
0.01275447,
-0.027381156,
-0.016862944,
-0.01405462,
0.011181288,
0.0104207015,
-0.03193168,
-0.01622587,
0.0051323418,
0.0023939009,
-0.0036241678,
0.0004867436,
-0.019190213,
0.025274914,
0.017552024,
-0.020802397,
0.0154197775,
-0.0017860809,
-0.02888933,
0.006517001,
-0.014223639,
0.005431376,
-0.025313918,
-0.0077943983,
0.010355693,
-0.005941685,
-0.017565025,
0.010784743,
-0.002177751,
-0.0068062847,
0.005668653,
0.020984419,
-0.0063707344,
0.007157325,
-0.012019886,
0.0028960838,
-0.005057583,
-0.013755585,
-0.0056198975,
0.008567988,
0.0023906506,
-0.011837864,
-0.010511711,
0.0014813582,
-0.012806476,
0.025209906,
-0.012884485,
-0.011376311,
-0.0009564227,
0.011857366,
0.03237373,
-0.010193175,
0.012962494,
0.019151207,
-0.007475862,
0.011142285,
0.0003225997,
0.018787166,
-0.011038273,
-0.018592143,
0.015588797,
0.0042124856,
-0.020451358,
-0.02558695,
-0.011785858,
0.0050608334,
0.033829898,
-0.030111471,
-0.025547944,
-0.046649378,
0.0039459546,
0.0033738888,
-0.033283837,
-0.019892292,
-0.011298303,
-0.03793837,
0.007839903,
0.0022248814,
-0.034922026,
0.027459165,
-0.029799435,
0.0022671362,
-0.012039388,
-0.02203754,
0.008808515,
0.014301648,
0.013482554,
-0.042540904,
-0.00221188,
-0.0016966956,
-0.010895256,
-0.021322457,
0.0069102966,
0.026835093,
0.036300182,
0.017591028,
0.015653804,
0.009049043,
-0.0037411812,
0.010908257,
0.010199675,
-0.0182151,
0.007345847,
-0.016446896,
0.021920526,
0.02394876,
-0.011382812,
-0.0051388424,
-0.0046902904,
0.018696155,
-0.007898411,
0.005840923,
-0.025079891,
-0.015809823,
-0.032243717,
-0.0061334567,
-0.015328767,
-0.020425355,
0.023025654,
-0.038224407,
-0.031359613,
0.014132629,
0.008964533,
0.0054898825,
-0.01569281,
0.024793858,
-0.027901215,
0.028005227,
0.0044822665,
-0.0190862,
0.0038256908,
-0.031853672,
0.009855136,
0.0060554477,
0.024572833,
-0.017838055,
0.012052389,
0.014379658,
-0.011831364,
0.006490998,
0.015302763,
-0.029201366,
-0.00073824136,
-0.0026068005,
-0.012279916,
-0.004505019,
-0.0063577327,
-0.01379459,
-0.028759316,
-0.013144515,
0.021101432,
-0.025560945,
0.019372232,
-0.008828018,
0.0030472262,
0.011993882,
-0.0016706926,
0.00841197,
-0.02159549,
0.048547596,
0.009101049,
-0.0014350404,
-0.024481822,
0.0182281,
0.001795832,
0.012734968,
0.037678342,
0.029825438,
-0.0018478379,
0.016771933,
-0.012955993,
0.032685768,
-0.02394876,
-0.021309456,
0.023194673,
-0.004615532,
-0.005301361,
-0.01379459,
-0.012162901,
-0.03780836,
-0.0013415922,
-0.01102527,
-0.013242026,
-0.0040564677,
-0.013859597,
0.0031544885,
0.033205826,
-0.0303715,
0.009614608,
-0.007072815,
-0.002499538,
0.0039329533,
-0.027563177,
-0.003497403,
0.0096796155,
0.015861828,
0.029617414,
-0.0033511363,
-0.00945209,
0.012546446,
0.0033673882,
0.013209523,
0.00485606,
-0.0039979606,
0.03408993,
0.010752239,
-0.007839903,
0.03791237,
-0.034167938,
0.02610701,
0.02402677,
-0.0017974572,
-0.017278992,
-0.029175363,
-0.0026425545,
0.021413468,
0.0019583507,
-0.03177566,
-0.0067477776,
-0.031307608,
0.0055678915,
-0.04953571,
-0.024416814,
0.010992767,
-0.038068388,
-0.02090641,
-0.018878175,
-0.014548677,
0.034219943,
0.015835825,
0.009777127,
-0.010128167,
0.04573927,
-0.033439856,
0.035000034,
-0.0033023807,
0.020867405,
-0.013508557,
0.021634493,
-0.022453588,
-0.0062082154,
0.00702731,
-0.0018202098,
-0.02445582,
-0.044621143,
-0.0009255442,
-0.0018543387,
0.023909755,
-0.00858749,
0.010440203,
0.0031301107,
0.0049568214,
-0.034896024,
-0.0073263445,
0.026263027,
-0.026185019,
-0.0048983144,
0.018800167,
-0.008483478,
-0.011460821,
-0.017825054,
0.003331634,
-0.012331922,
0.0025141647,
-0.0068582906,
-0.002933463,
0.031957682,
-0.013820593,
0.007872407,
-0.025846979,
-0.0022866386,
-0.02064638,
0.019021193,
0.0067087733,
-0.0060684495,
-0.014691694,
-0.000060944523,
0.00676728,
0.005668653,
-0.028447278,
-0.0021403716,
-0.015757816,
-0.010329691,
-0.014392659,
-0.0011254422,
-0.007696887,
0.019827286,
0.016108857,
-0.008606992,
-0.011428317,
0.0054671303,
-0.04170881,
-0.014132629,
-0.0016950704,
0.015848827,
-0.008711004,
0.023844749,
-0.0008081244,
0.012474938,
0.0035526594,
0.016160863,
-0.026055003,
-0.02108843,
0.017317995,
-0.027355153,
0.04139677,
0.0060294447,
-0.016342884,
-0.01665492,
0.034766007,
0.00036322937,
-0.028161246,
0.028915333,
-0.01084325,
0.018592143,
-0.01804608,
0.014522674,
0.012507441,
-0.01604385,
0.0047878018,
-0.010791244,
0.018683154,
-0.0064682453,
-0.004384755,
0.012195406,
-0.032139704,
0.006100953,
0.009120551,
-0.014041618,
-0.02881132,
-0.03494803,
0.0115583325,
-0.0014488545,
-0.0088345185,
0.009504096,
0.0019258469,
0.022180557,
0.024312802,
0.0012652084,
0.0054508783,
-0.004401007,
-0.0077683954,
-0.010349193,
-0.008450974,
-0.016589912,
-0.03780836,
0.0021484976,
0.01075874,
-0.029513402,
0.0063382303,
-0.022310572,
-0.029019345,
-0.044985186,
0.043607026,
-0.0020964916,
-0.025183903,
-0.0035104046,
0.019489245,
-0.027173132,
0.008672,
-0.0012465187,
0.008899526,
-0.005161595,
-0.003565661,
0.00850298,
0.0030667284,
-0.0040369653,
-0.02055537,
-0.01960626,
-0.0051420927,
0.0050348304,
0.18794966,
-0.030787548,
-0.004807304,
0.023051657,
-0.01787706,
0.012721966,
0.025898986,
0.02933138,
0.017278992,
0.024663843,
0.022024538,
-0.013495555,
-0.018462127,
0.004631784,
0.006845289,
0.0031642397,
-0.035026036,
-0.016121859,
0.03115159,
-0.010193175,
0.0019453493,
-0.0154717835,
-0.0038549444,
-0.01838412,
0.020867405,
0.00624722,
0.00963411,
-0.0031122337,
0.030111471,
-0.012533445,
-0.0076903864,
0.0050088274,
-0.0028863326,
0.014106626,
-0.020451358,
0.010544215,
-0.009400084,
-0.010056659,
-0.0025125395,
0.0010945636,
0.002246009,
0.002993595,
-0.017968072,
-0.015497786,
0.009088048,
-0.011376311,
-0.0014594182,
-0.002161499,
0.005538638,
0.0043685036,
-0.038042385,
-0.00051274657,
0.015029732,
0.023961762,
-0.0027368155,
0.006689271,
0.02595099,
0.0039004495,
-0.007833403,
0.0006813598,
0.0102126775,
-0.010609223,
-0.0016934451,
0.020230332,
-0.022986649,
0.027745198,
-0.021660497,
-0.020789396,
-0.0009905517,
-0.002499538,
0.007254836,
-0.0127479695,
-0.021621492,
-0.003981709,
0.012884485,
-0.008054429,
0.015458782,
0.0034941528,
-0.006575508,
0.01405462,
-0.0069623026,
-0.015289762,
-0.022791628,
0.016329883,
-0.025638955,
-0.033205826,
0.0032731274,
0.016706925,
-0.014704695,
0.0063382303,
0.0073263445,
0.0004891814,
-0.01569281,
0.020750392,
0.013729583,
-0.0064259907,
-0.009016539,
0.0037769354,
-0.010095663,
-0.025469936,
-0.01657691,
0.071196206,
-0.005883178,
0.008366465,
-0.01700596,
-0.023727736,
-0.041448776,
0.0061497088,
0.018319111,
-0.00036201047,
-0.0055808933,
-0.05580243,
-0.0032129954,
-0.026731081,
-0.012130398,
0.04243689,
0.035208058,
-0.00581492,
-0.002835952,
-0.020282337,
-0.013229025,
-0.012169403,
0.03200969,
0.033803895,
-0.0032211212,
0.008223448,
-0.025794974,
-0.023103664,
-0.011174788,
-0.04407508,
0.0046382844,
-0.0066957716,
-0.036690228,
0.008418471,
0.007137823,
-0.0077878977,
-0.013482554,
0.0040987222,
-0.0138335945,
0.02099742,
-0.019242218,
-0.0050640837,
-0.009471592,
0.0014894842,
0.03364788,
-0.039420545,
-0.0031869924,
0.013281031,
-0.020074314,
0.014912719,
-0.01353456,
0.009510596,
-0.022752622,
-0.010914758,
0.029721426,
-0.027797204,
-0.014223639,
-0.03661222,
-0.01379459,
0.02159549,
-0.012390428,
0.013989612,
0.022492593,
-0.022141552,
0.009211562,
0.013703579,
-0.1630908,
0.012968995,
0.01847513,
-0.033777893,
0.0027335652,
0.007729391,
0.014509672,
0.009790128,
-0.015978841,
-0.0076123774,
0.03835442,
-0.01006316,
-0.03403792,
-0.023194673,
-0.000893853,
-0.0055678915,
0.012390428,
0.040226635,
0.018280108,
-0.00090035377,
0.020932412,
-0.036976263,
0.009816132,
-0.010141169,
0.008997037,
0.0032487495,
-0.0034714001,
0.027121127,
0.0027871963,
0.012188905,
-0.0062667225,
0.014028617,
0.017083969,
-0.0014326026,
0.007176827,
0.016303878,
-0.01440566,
-0.0073393458,
-0.007891909,
0.0006886731,
0.034557983,
0.02385775,
0.0026490553,
0.009562602,
0.0068322876,
0.02472885,
0.017916065,
-0.0010571843,
0.021569487,
0.0066697686,
0.022310572,
-0.007833403,
0.029253371,
0.010680731,
-0.01162984,
0.003633919,
-0.014067621,
0.012338422,
0.017604029,
-0.0005391559,
-0.012832479,
-0.039342534,
0.027563177,
-0.012682962,
0.01917721,
-0.030163476,
-0.018553138,
-0.004257991,
-0.010602722,
0.003981709,
-0.01865715,
-0.007397853,
-0.012871483,
-0.044023074,
0.029175363,
0.01753902,
-0.023571717,
-0.00040223385,
-0.009699118,
-0.014132629,
-0.001439916,
-0.013021001,
-0.032633763,
-0.030319495,
0.014652689,
-0.005051082,
0.02039935,
-0.008860521,
-0.009608108,
-0.0067282757,
0.033699885,
-0.028265258,
0.0019599758,
-0.026315033,
-0.012526944,
0.011584335,
-0.012786974,
-0.008021925,
-0.0032178708,
0.00971862,
0.012435934,
-0.019762278,
-0.014756701,
0.023753738,
0.029643416,
0.016589912,
-0.021855518,
-0.011096779,
0.023389695,
-0.021647494,
-0.008776012,
-0.0049048155,
0.01154533,
0.007963418,
0.0030992322,
0.024858866,
0.013573565,
-0.021946529,
0.027225139,
-0.025781972,
0.054866325,
-0.007605877,
-0.010700233,
0.017304994,
0.0046447855,
-0.005772665,
-0.11722151,
-0.011493324,
-0.00056719035,
0.027121127,
0.03286779,
0.03679424,
-0.010342692,
0.00017125411,
-0.007449859,
0.027121127,
-0.017916065,
0.0022183806,
-0.016927952,
0.00066429534,
0.03359587,
0.0017487016,
-0.0004623658,
-0.025976993,
-0.025027884,
0.033205826,
0.017031964,
-0.03193168,
-0.0017161978,
-0.01656391,
-0.005213601,
0.0030244736,
-0.028187249,
0.009393583,
0.010778243,
0.023285683,
0.014418662,
0.009055544,
0.00018151311,
-0.015094739,
-0.013625571,
-0.01414563,
0.015523789,
-0.013443549,
0.04233288,
0.0070923176,
0.0046187826,
0.015432779,
0.01604385,
-0.017838055,
0.006195214,
0.0015821198,
-0.0242868,
-0.021179441,
0.0069688032,
-0.015640803,
-0.0038029384,
-0.021153439,
-0.023012653,
0.01700596,
0.003523406,
-0.018722158,
0.005421625,
0.010329691,
-0.023493707,
-0.0095756035,
-0.009926644,
0.021998536,
-0.026939105,
0.021556485,
0.017721042,
-0.021972533,
-0.009530098,
-0.010173673,
0.0018413372,
-0.013599567,
0.014080623,
0.010089163,
-0.012728467,
-0.012331922,
-0.022245564,
0.014912719,
-0.008372965,
-0.0017844557,
0.014262644,
-0.035546098,
0.00038496623,
-0.0051680957,
0.024117779,
0.0049698227,
0.00095317233,
0.007053313,
0.0146266855,
-0.010381697,
-0.005951436,
-0.014769702,
0.023961762,
0.055490397,
0.01795507,
-0.02289564,
-0.00062325934,
-0.0021029925,
0.007839903,
-0.004501769,
0.040876713,
0.019463243,
-0.012500941,
-0.008275454,
-0.053410158,
0.016719928,
0.0074693607,
-0.0074303565,
0.0024361557,
-0.024429815,
-0.02977343,
-0.013105511,
0.016680922,
0.019528251,
-0.0065202513,
0.024143783,
-0.006269973,
-0.00017775486,
-0.0038386923,
-0.013417547,
0.03721029,
0.015380773,
0.025547944,
0.03957656,
-0.009361079,
0.020854404,
0.0058604255,
0.015822824,
0.0013180269,
0.008028425,
0.018670151,
0.03869246,
-0.009770626,
-0.02134846,
0.017370002,
-0.017916065,
-0.015900834,
0.010284185,
-0.0024605335,
-0.017747045,
-0.0087825125,
0.0045082695,
0.008262453,
0.014548677,
-0.002749817,
-0.012819477,
-0.00937408,
0.004332749,
-0.019372232,
0.0010271184,
-0.032919794,
0.008047927,
0.021335458,
-0.009588605,
-0.00035652547,
0.01414563,
0.017994074,
-0.031541634,
-0.028759316,
0.017916065,
-0.0069883056,
-0.0071183206,
-0.010407699,
-0.03973258,
0.015627801,
0.015224755,
0.012851981,
-0.014600683,
0.023493707,
0.00014342277,
-0.010966764,
0.013807591,
0.018020077,
-0.020867405,
-0.018176096,
-0.0045245215,
-0.014002614,
0.0017519519,
0.001839712,
-0.022687616,
-0.026002998,
0.0077358917,
0.014132629,
0.022076545,
-0.010485709,
0.00858749,
-0.011467322,
0.02541793,
0.024156785,
0.009244066,
-0.005421625,
0.019970302,
0.0005143718,
0.010940761,
-0.0012603328,
0.018059082,
0.0154197775,
0.0120068835,
0.01622587,
0.016082853,
-0.0034388963,
-0.014444665,
0.0046382844,
0.005457379,
-0.018319111,
0.006191964,
-0.023805743,
-0.007930914,
-0.0039069504,
0.0028765816,
0.0027969473,
-0.027485168,
-0.0092830695,
-0.007293841,
0.015718812,
0.01414563,
0.01492572,
0.00459928,
-0.002835952,
0.009016539,
-0.009016539,
0.019892292,
-0.017565025,
0.01640789,
-0.0024832862,
0.010056659,
-0.009777127,
0.024143783,
0.007020809,
0.0102126775,
0.024247795,
-0.008873522,
0.018254103,
-0.0017357001,
0.0037476819,
-0.0042904946,
-0.032139704,
-0.0076318798,
0.0034388963,
-0.028265258,
0.001839712,
-0.0034486474,
0.0034161438,
0.06729576,
-0.0071183206,
-0.009959148,
0.026653072,
-0.012988497,
0.05067984,
0.018540137,
0.010914758,
-0.025729965,
0.0016325007,
-0.0031918678,
-0.032607757,
-0.0037184285,
-0.061315067,
-0.02732915,
0.013599567,
-0.013638572,
-0.0024410314,
-0.00945859,
-0.02933138,
-0.003617667,
-0.021478476,
0.024767855,
-0.0052038496,
-0.030137474,
0.00011914654,
0.036690228,
0.004739046,
0.005135592,
-0.023402696,
-0.008951532,
0.018033078,
-0.022700617,
-0.011005769,
0.023467705,
-0.007228833,
-0.0063967374,
-0.012396929,
0.0046935407,
-0.005733661,
0.0069818045,
0.005057583,
-0.023116665,
-0.019099202,
-0.019359231,
-0.009120551,
-0.014509672,
-0.0208284,
-0.024429815
] |
Chemical-protein interaction (CPI) is the central topic of target identification and drug discovery. However, large scale determination of CPI is a big challenge for in vitro or in vivo experiments, while in silico prediction shows great advantages due to low cost and high accuracy. On the basis of our previous drug-target interaction prediction via network-based inference (NBI) method, we further developed node- and edge-weighted NBI methods for CPI prediction here. Two comprehensive CPI bipartite networks extracted from ChEMBL database were used to evaluate the methods, one containing 17,111 CPI pairs between 4,741 compounds and | [
-0.009377771,
0.019565035,
0.01180625,
-0.025711693,
0.0068635405,
0.028428297,
0.0052548447,
-0.01054399,
-0.04096858,
-0.037511084,
0.002680588,
0.029388713,
-0.003800501,
0.026438866,
-0.0015109393,
0.017973488,
0.031035138,
0.0037593404,
-0.00096641807,
0.0046442947,
-0.043959588,
0.009617874,
-0.019125987,
-0.01794605,
-0.019647356,
0.019386671,
0.0236811,
-0.03622138,
-0.0055018086,
-0.030376568,
-0.003673589,
-0.0015409522,
-0.023173453,
0.005783073,
0.007230556,
-0.002557106,
0.0033031432,
-0.0070110327,
0.021664228,
-0.003546677,
0.02798925,
0.014680636,
0.0007245992,
0.015476409,
-0.00280064,
0.00035886953,
0.013185132,
-0.00048492404,
-0.029498475,
0.010742933,
0.004201818,
0.024682676,
-0.018755542,
-0.0058894046,
-0.0020340227,
-0.012807826,
0.01672495,
0.02058033,
0.011058498,
-0.020868456,
-0.012197277,
0.009837398,
-0.024504313,
0.017520722,
-0.012073794,
-0.021252621,
0.006647447,
0.013823123,
0.016519146,
-0.022857888,
0.027262079,
0.030705854,
-0.00045105224,
-0.0043939007,
0.025986098,
-0.001460346,
-0.034931682,
-0.005398907,
-0.01114768,
0.018549738,
0.01616242,
-0.009171967,
0.016340783,
0.018151851,
0.0033202935,
-0.00557041,
0.023132293,
0.011888571,
0.020251045,
-0.0092885895,
0.0311449,
0.022007234,
-0.0011842266,
-0.00086094387,
-0.024463154,
0.010331326,
-0.014063226,
0.023763422,
-0.0055909897,
-0.023818303,
0.009665895,
0.01181997,
-0.0348768,
-0.01809697,
-0.0049392795,
0.025821455,
0.005275425,
-0.023749702,
0.028208774,
0.02798925,
0.00930231,
0.023886904,
0.007395199,
-0.018234173,
-0.00043626013,
-0.019235749,
0.014049506,
-0.022638364,
-0.006537685,
-0.01677983,
0.020964498,
0.015997777,
0.027207198,
-0.018837864,
0.018975066,
0.021019379,
0.00014845708,
-0.024284791,
0.0011988042,
-0.0038999727,
-0.010790953,
0.0033871795,
0.0022398261,
0.024325952,
-0.028812464,
0.0049255593,
0.015929176,
-0.03677019,
-0.029553356,
-0.021444704,
0.009988321,
0.035151206,
-0.026425146,
-0.0034283402,
-0.005522389,
0.03432799,
0.0062598507,
0.018536018,
-0.007388339,
0.0029961532,
-0.00015167275,
0.004109206,
-0.0066062864,
0.019016227,
-0.0044419216,
0.024957081,
0.014996201,
0.036934834,
0.011723928,
-0.020786135,
0.0051896735,
-0.013157692,
0.004496802,
0.0025433858,
0.022528602,
0.011771949,
0.005361176,
-0.007786225,
0.016820991,
-0.022158157,
0.020429408,
0.03484936,
-0.01617614,
0.027687406,
-0.0048878286,
-0.018728102,
0.039047748,
0.013171412,
-0.01868694,
-0.015243165,
0.008918144,
0.0139191635,
0.012924448,
-0.0032191067,
-0.0008227845,
-0.01491388,
0.02108798,
-0.0057350523,
-0.0077656447,
-0.044645596,
0.0064313533,
0.014598315,
-0.011024198,
-0.004050895,
-0.643643,
-0.023763422,
0.010935016,
-0.036550667,
0.02488848,
0.032709006,
0.013576158,
0.0109075755,
0.012210997,
0.041352745,
0.0020357377,
-0.005110782,
0.011024198,
-0.013569298,
-0.026013538,
-0.020209884,
-0.008794662,
-0.033669423,
0.018700661,
-0.0063696126,
-0.022267919,
-0.001807639,
-0.016656348,
0.023763422,
-0.009219988,
-0.020264765,
0.013342914,
-0.026493747,
-0.0013951749,
0.01550385,
0.0065479754,
0.015023641,
-0.0068738307,
0.0044247713,
0.04162715,
0.0028709562,
0.015462689,
0.013548718,
0.019949201,
0.01745212,
-0.043904707,
-0.022336518,
0.018412536,
0.0069527216,
-0.02052545,
0.004054325,
-0.003615278,
0.003040744,
-0.01307537,
-0.013013629,
-0.010468529,
0.0017750536,
-0.030925378,
-0.01181311,
0.002119774,
-0.0025965518,
0.020470569,
-0.024751278,
0.013857423,
0.02486104,
0.0058448142,
-0.029333832,
-0.007793085,
-0.044508398,
-0.01811069,
0.013246873,
-0.022514882,
-0.011037918,
-0.009782517,
0.0011507835,
0.005920275,
0.015270606,
-0.00013602313,
-0.014515993,
0.012766666,
0.018728102,
0.024024107,
0.013555578,
-0.009453232,
0.0022672664,
0.0006872973,
0.005783073,
-0.030349128,
-0.01809697,
0.022075836,
0.005724762,
-0.002733754,
0.00809493,
0.009034765,
-0.016958192,
0.01861834,
-0.015202004,
-0.012828406,
-0.038718462,
-0.026576068,
0.013713361,
0.002678873,
0.0016335638,
0.02797553,
-0.027659966,
-0.017109115,
-0.03476704,
0.0005878257,
-0.009720776,
0.009720776,
0.0162173,
0.006791509,
0.0012348199,
0.043273576,
-0.0066988976,
0.011559286,
-0.031638827,
-0.020868456,
-0.01672495,
0.015380368,
-0.029525915,
0.021266341,
0.00869176,
-0.012945028,
-0.009213128,
-0.0043836106,
0.0004375464,
0.0031882364,
0.0034729308,
-0.005477798,
-0.0035638274,
0.0013943175,
-0.015517569,
-0.0069149914,
-0.016038937,
0.014708077,
-0.0053028655,
0.005055901,
-0.00057839305,
0.019222029,
0.009192548,
0.0008197832,
-0.003047604,
-0.008581998,
-0.0335871,
-0.013610459,
-0.021307502,
0.009542413,
-0.0019568466,
-0.018481137,
-0.021911193,
-0.023982946,
0.024792438,
0.01364476,
0.0023804584,
0.011010477,
0.0029481323,
-0.0019379812,
0.0103519065,
0.010777233,
-0.0003822368,
-0.010784093,
-0.0009844259,
-0.010935016,
-0.035535373,
-0.025519611,
0.016450545,
-0.01491388,
-0.010653751,
-0.0141455475,
-0.008314454,
0.024655236,
0.00929545,
-0.013452676,
-0.044727918,
0.015215725,
-0.0115798665,
-0.013836843,
0.028318536,
-0.011984613,
0.011346622,
-0.0061432286,
-0.0047780667,
0.0032276819,
-0.0122452965,
-0.003289423,
-0.0010624595,
-0.018906465,
-0.0111339595,
0.044645596,
0.0045173825,
0.03967888,
0.0114083635,
0.0014629185,
0.022803007,
0.0069527216,
0.019153427,
-0.0071756756,
0.017246317,
-0.014858999,
-0.0051965336,
0.016519146,
0.020251045,
-0.009686476,
0.02052545,
0.04223084,
0.010214704,
0.014461112,
-0.013884863,
-0.012588303,
-0.01673867,
-0.007827386,
-0.030211926,
0.0069527216,
-0.000050995273,
0.00992658,
-0.013288034,
-0.016642628,
-0.03421823,
0.008547697,
0.007745065,
-0.026699549,
-0.010804674,
-0.0038896825,
-0.0007417494,
0.0051347925,
-0.019249469,
0.028071571,
-0.000901247,
0.0017836287,
0.0055909897,
0.0028709562,
0.021636788,
0.01120256,
-0.009014185,
-0.014666916,
0.00808121,
0.02174655,
-0.014762958,
0.005916845,
0.003848522,
0.020813575,
-0.0038210815,
0.05784445,
0.014090667,
-0.010297026,
0.035535373,
0.0045311027,
-0.019770838,
0.021211462,
-0.00806749,
0.015531289,
0.038444057,
-0.0099403,
0.028730143,
-0.005031891,
0.010722352,
-0.034959123,
0.0035569672,
0.021609347,
-0.0273444,
0.024353392,
0.036879953,
0.05328934,
0.034410313,
0.015929176,
-0.008328174,
-0.0009681331,
-0.00066971825,
0.019715957,
-0.0099608805,
0.004297859,
0.0038142214,
-0.01809697,
-0.0022929918,
-0.011778809,
-0.019002507,
-0.006342172,
-0.017273758,
0.027522763,
0.017685365,
-0.002296422,
0.015599891,
0.018316494,
0.013006769,
-0.04041977,
-0.011566146,
0.028922224,
0.009741357,
-0.005820804,
0.0035706875,
-0.02859294,
0.0067640687,
-0.009549273,
0.012183556,
-0.007745065,
0.015435249,
0.0150922425,
0.018988786,
-0.031199781,
-0.03350478,
0.02560193,
-0.006424493,
0.0001262689,
0.008485956,
0.009185688,
0.0056390106,
-0.0017373229,
-0.022816727,
0.04415167,
-0.0033700292,
-0.013390935,
-0.015956616,
-0.0004268275,
0.0043321596,
0.01688959,
0.0053714663,
0.0051759533,
-0.0138094025,
0.006071198,
0.0064587938,
0.0034609258,
0.01863206,
-0.00019079683,
-0.0029944382,
0.006386763,
-0.036523227,
0.011127099,
0.017136555,
0.021266341,
0.01303421,
0.010324466,
0.022487441,
-0.0062461304,
-0.023324376,
-0.01738352,
-0.015833134,
0.0106263105,
-0.0055566896,
0.0053748963,
-0.005409197,
0.0034952261,
0.010715492,
0.0028829614,
0.012190416,
0.007216836,
-0.045194406,
0.00052008213,
0.010859555,
0.0092885895,
0.0012159545,
0.021019379,
0.01123686,
0.0013720221,
-0.002858951,
0.02674071,
0.024092708,
0.0040783356,
-0.011909151,
-0.012142396,
0.007532401,
-0.0018539449,
0.009857979,
-0.031419307,
-0.011751369,
0.015366647,
0.02491592,
0.010873275,
-0.007141375,
0.013775102,
-0.0027680546,
0.008520257,
0.01676611,
-0.010681191,
-0.017465841,
0.025560772,
0.007525541,
-0.02055289,
-0.019222029,
0.014694356,
0.009713916,
-0.000821927,
-0.02114286,
0.008883843,
0.0028709562,
-0.0129724685,
-0.023900624,
0.0073608984,
-0.027001394,
-0.018247893,
-0.035233527,
0.005306295,
-0.019098546,
0.00064613664,
-0.014762958,
-0.014955041,
-0.027797166,
-0.0050010206,
-0.0100157615,
-0.0023856033,
-0.030952819,
-0.008389915,
-0.016601468,
-0.00017686222,
0.012286457,
0.02798925,
-0.009219988,
-0.01930435,
0.016313342,
-0.023996666,
-0.020744974,
0.0028383706,
-0.031391867,
-0.0008682327,
0.007909707,
-0.019029947,
-0.018810423,
-0.015352927,
0.0010221564,
-0.020264765,
-0.018810423,
0.013980905,
0.003423195,
0.015407808,
0.010475389,
0.014680636,
0.03290109,
0.012217857,
-0.03174859,
0.009556133,
-0.020635212,
0.0034609258,
-0.032763887,
0.0006954437,
0.0049392795,
-0.0018728101,
0.0012365349,
-0.0058962647,
-0.0039239833,
0.003845092,
-0.01679355,
0.0051210723,
0.0142004285,
0.014488553,
0.013006769,
-0.014612035,
0.021458425,
0.014790398,
-0.011566146,
-0.012951888,
0.007882267,
0.012053214,
0.01244424,
-0.026973953,
0.0002347444,
-0.017781407,
-0.015462689,
-0.012169836,
-0.012156116,
-0.010427368,
0.021609347,
0.0038382318,
-0.03048633,
-0.014515993,
0.012746085,
0.0019534165,
0.0028486608,
-0.018947626,
-0.025972378,
-0.007710764,
-0.01118884,
0.025327528,
0.0012356774,
0.008808382,
-0.03435543,
-0.0017630483,
0.017013073,
-0.016038937,
0.014598315,
0.015105963,
-0.00930917,
-0.029059427,
-0.013089091,
-0.0248336,
-0.02107426,
-0.029306391,
0.0052376944,
0.044288874,
0.035782337,
0.034547515,
0.008129231,
0.0010204414,
0.008424216,
0.011305462,
-0.00058439566,
-0.0012065219,
0.009967741,
-0.0223914,
0.021376103,
0.021307502,
-0.029388713,
0.00027483318,
-0.0054297773,
0.0046991757,
0.019194588,
-0.0056355805,
-0.026274223,
-0.011511265,
-0.014474832,
-0.022199318,
0.011161399,
0.0000467613,
0.015284326,
-0.04549625,
-0.0024696398,
0.017822567,
0.0042704185,
0.033614542,
-0.0023290075,
0.02676815,
-0.00020655364,
0.012540282,
-0.004541393,
0.009439512,
-0.018494857,
-0.019098546,
-0.01364476,
0.00811551,
0.02176027,
-0.02484732,
0.027906928,
0.01623102,
-0.0013265738,
-0.005213684,
0.010324466,
-0.016532866,
0.007635303,
0.0096247345,
-0.0066577373,
-0.0071139345,
-0.027577644,
-0.031062579,
-0.030211926,
-0.00094240764,
0.02491592,
-0.010763513,
0.017863728,
-0.020017803,
0.0044213412,
0.041956436,
-0.0046271444,
0.02108798,
-0.01673867,
0.0535363,
0.025300087,
0.019757118,
-0.0066543072,
-0.00041310728,
-0.007937147,
0.00078248134,
0.008218412,
0.023818303,
-0.013843703,
-0.017314918,
0.0011353482,
-0.006403913,
-0.02421619,
-0.050764818,
-0.00055867026,
-0.03177603,
0.012334478,
-0.033861503,
-0.01555873,
-0.0285655,
0.023296935,
-0.022706965,
0.0017939189,
-0.0031779462,
-0.016807271,
0.011374063,
0.027234638,
-0.0062358403,
0.024408273,
-0.014680636,
-0.014131827,
-0.0060574776,
0.0020803285,
0.010502829,
0.0030270237,
0.023516458,
0.028263655,
0.00248679,
0.006897841,
0.007786225,
0.014131827,
0.009672755,
-0.0019174009,
-0.0063044415,
0.043712623,
0.015051082,
0.00057153293,
0.012307038,
-0.020731254,
0.024476875,
-0.010447948,
-0.0010933301,
-0.035562813,
-0.025519611,
0.0041709472,
0.024504313,
0.014845279,
-0.0015392372,
0.0039685736,
-0.014227869,
0.023475297,
-0.03155651,
0.002054603,
0.029717999,
-0.02980032,
-0.0054949485,
0.008794662,
0.0032739877,
0.017328639,
0.016025217,
-0.00014470545,
0.0011928016,
0.020415688,
-0.029690558,
0.025368689,
0.013349774,
0.016477985,
-0.030129604,
0.00872606,
-0.03432799,
-0.020196164,
0.012890147,
-0.012046354,
-0.023214614,
0.004411051,
0.010091222,
0.014104387,
0.03347734,
-0.008623159,
0.029635677,
0.02549217,
-0.0012871282,
-0.016930752,
0.0054915184,
0.005261705,
-0.01490016,
0.016848432,
0.025766574,
-0.02609586,
0.017465841,
-0.03679763,
0.0049324194,
0.0058825444,
-0.02731696,
-0.029580796,
-0.035233527,
0.016505426,
-0.0028452307,
-0.0019602766,
0.004915269,
0.0028898215,
-0.01983944,
0.0033871795,
-0.003236257,
-0.012650044,
0.0018865303,
-0.007964588,
-0.0049358495,
-0.005714472,
-0.023296935,
-0.025313808,
-0.015366647,
-0.026713269,
-0.048240297,
0.014049506,
-0.009480673,
0.022226758,
0.025574492,
-0.04168203,
-0.034410313,
-0.033175495,
-0.015078522,
-0.012560862,
-0.009192548,
0.007923427,
-0.030129604,
0.002613702,
0.0077244844,
0.031446747,
-0.0125814425,
0.009165107,
0.0030561793,
-0.004651155,
0.0033185785,
-0.015256885,
0.02056661,
0.018234173,
-0.018330215,
-0.00745008,
0.03542561,
0.0053851865,
-0.00080606295,
0.012650044,
-0.006071198,
-0.0020168724,
0.005309725,
-0.006674887,
0.0033048582,
0.028071571,
0.016381944,
-0.018837864,
0.0065548355,
0.008485956,
-0.0076696035,
-0.0052376944,
-0.00991972,
-0.007388339,
0.004788357,
-0.020841016,
-0.032242518,
-0.032489482,
-0.004092056,
-0.016011497,
-0.0013891724,
-0.010331326,
0.01243738,
0.011435804,
-0.0020014371,
0.0060471874,
-0.03490424,
0.00869862,
0.002555391,
-0.01735608,
0.020333366,
0.005663021,
0.01122314,
-0.00870548,
0.01742468,
-0.016381944,
0.006637157,
-0.011902291,
0.0000835004,
-0.010928156,
0.009398351,
0.01735608,
-0.0069321417,
0.005913415,
-0.0078411065,
-0.017218877,
-0.03583722,
-0.0065033846,
-0.0037799207,
-0.053207017,
-0.00049950177,
-0.016601468,
-0.0012391075,
-0.0027903498,
-0.002611987,
0.006417633,
-0.02417503,
0.030239366,
0.20635211,
-0.0013968899,
0.01793233,
0.014172988,
0.009473813,
0.0011919441,
0.0096247345,
0.009000464,
0.018810423,
0.013939744,
0.017273758,
0.01676611,
-0.006342172,
-0.0043767504,
0.01115454,
0.008307594,
-0.032132756,
-0.023598779,
-0.019661076,
-0.0108526945,
-0.014502273,
0.010790953,
0.014365071,
-0.0099608805,
0.001243395,
-0.000821927,
0.004702606,
-0.00073231675,
0.011545566,
0.005052471,
-0.02299509,
0.02491592,
-0.0013488692,
0.0080606295,
0.00038609558,
0.0050627613,
-0.00043840392,
-0.029745439,
0.003171086,
-0.003483221,
-0.0022689814,
0.0020254476,
0.0004416196,
-0.029608237,
-0.017273758,
0.0013797397,
-0.007882267,
-0.030404009,
0.009542413,
0.019235749,
-0.03287365,
0.019619916,
0.019811999,
0.025986098,
0.0010916151,
0.012039494,
-0.004489942,
0.006578846,
0.010502829,
0.008945584,
-0.00869176,
0.0069561517,
-0.01053027,
0.018206732,
-0.0064930944,
0.013596739,
-0.0087878015,
0.006668027,
0.025752854,
-0.010756653,
0.01114768,
-0.00932289,
-0.0037627704,
0.0030596093,
-0.019688517,
-0.011360343,
0.027509043,
0.026383985,
0.037428763,
0.018933905,
-0.0045654033,
-0.00039638576,
-0.03174859,
0.003608418,
-0.04730732,
0.004791787,
0.02112914,
-0.023969226,
-0.021389823,
0.0058962647,
0.0040783356,
0.008904424,
-0.025121724,
0.0007211691,
0.028757583,
0.0038965426,
-0.0020837586,
-0.004476222,
-0.012999909,
0.001365162,
-0.04099602,
0.07650395,
0.016038937,
0.004040605,
-0.020415688,
-0.00034922248,
-0.010729212,
-0.003231112,
0.00870548,
0.009268009,
-0.012156116,
-0.015709653,
0.009885419,
-0.013130251,
-0.0053303055,
0.030376568,
0.004229258,
-0.025560772,
0.0048363777,
-0.008136091,
0.004856958,
-0.02230908,
-0.018220453,
0.03098026,
-0.0010950451,
-0.006963012,
-0.0017047374,
-0.015311766,
-0.004544823,
-0.007868547,
0.013795682,
-0.012787246,
0.007916567,
0.0033237236,
-0.0060643377,
0.00341462,
0.018261613,
-0.0007271717,
-0.013281174,
0.009453232,
-0.0024199039,
-0.0136996405,
-0.02369482,
-0.006880691,
0.014529713,
0.028483178,
0.010502829,
0.027906928,
0.014584594,
-0.016340783,
0.0041812374,
-0.016656348,
0.013802542,
-0.008142951,
0.03232484,
-0.023324376,
0.0071070744,
-0.01794605,
0.006585706,
-0.008856403,
-0.03287365,
-0.014159268,
0.02247372,
0.020333366,
-0.021005658,
0.012986189,
-0.17550907,
0.019523874,
0.03051377,
-0.014008345,
0.0005955433,
0.025643092,
-0.007271717,
-0.004404191,
0.013219433,
-0.029855201,
0.01429647,
-0.000899532,
0.0029772879,
-0.053207017,
0.010701772,
0.020676373,
-0.016656348,
0.022501161,
0.009782517,
0.0014389082,
0.018879024,
-0.003845092,
0.0028332255,
-0.006078058,
0.012176696,
0.017644204,
-0.012060074,
-0.022899048,
0.0019362662,
-0.013459536,
-0.014955041,
0.0024644947,
0.010502829,
0.019633636,
0.0361665,
0.0007430357,
0.005309725,
0.004054325,
-0.005663021,
0.02804413,
0.033861503,
0.033641983,
0.009590434,
0.0040200246,
-0.024586635,
0.0011893717,
0.02107426,
-0.0026462877,
0.03237972,
-0.009370911,
0.00082535704,
-0.0070727738,
0.027124876,
-0.005368036,
0.013205713,
0.008623159,
0.007285437,
0.02922407,
0.0010324466,
-0.0112986015,
-0.0063970527,
-0.009707056,
0.028675262,
-0.002104339,
-0.007326598,
-0.01616242,
-0.0017064525,
-0.00036958844,
-0.014625755,
-0.007134515,
-0.00869862,
0.0044453517,
0.001432048,
0.000994716,
0.013624179,
-0.0013171412,
-0.01982572,
-0.0104616685,
0.009590434,
-0.002248401,
0.008581998,
0.005422917,
0.010098082,
-0.0053714663,
-0.018439976,
-0.010434228,
0.013281174,
0.00013945319,
-0.0048912587,
-0.014392512,
0.002046028,
-0.02608214,
0.007923427,
-0.018508578,
-0.004599704,
0.013260594,
0.0038313717,
0.012759806,
0.021321222,
-0.009453232,
0.00433902,
0.0061020683,
-0.010098082,
0.02177399,
0.0013325764,
0.008142951,
-0.00930231,
-0.023928065,
0.011490685,
0.0037662005,
-0.0060643377,
-0.0071207946,
0.001458631,
0.027550204,
-0.02675443,
0.034465194,
-0.026713269,
-0.0063078715,
-0.011655328,
-0.033614542,
0.062399562,
0.0030493191,
-0.0074981004,
0.023982946,
-0.027124876,
0.007209976,
-0.12128675,
-0.020882176,
-0.009638455,
0.019496433,
-0.004290999,
0.02674071,
-0.0063661826,
0.016368223,
-0.030211926,
0.03421823,
0.0023838882,
-0.015215725,
-0.004452212,
-0.00933661,
-0.00683267,
0.008828962,
-0.0041915276,
-0.003851952,
0.013397795,
0.025094284,
0.0116347475,
-0.017987208,
0.005028461,
-0.0018951055,
0.0034249101,
0.015174564,
-0.011470105,
0.025739133,
0.011881711,
-0.0028263654,
0.018892745,
-0.022748126,
0.017987208,
0.011332902,
-0.018975066,
-0.00083221716,
-0.0027526193,
-0.030349128,
0.030760735,
-0.021197742,
0.0061500887,
0.007957728,
-0.004603134,
0.027495323,
0.012492261,
-0.0033751742,
-0.0021900903,
0.0061020683,
-0.008925004,
-0.0038073612,
0.0008575138,
-0.033120614,
-0.02177399,
0.009494393,
0.01243738,
0.0041743773,
0.008369335,
0.008890703,
-0.017246317,
-0.0007610435,
-0.017136555,
-0.001800779,
-0.03117234,
0.016683789,
0.015188284,
0.0017038799,
-0.035809778,
-0.01491388,
0.007333458,
-0.016093818,
-0.012224717,
-0.008911284,
-0.0091788275,
0.0028520909,
-0.04162715,
-0.022158157,
0.0006422778,
-0.02487476,
0.02927895,
-0.013404655,
-0.008581998,
-0.03339502,
0.002979003,
-0.013480117,
0.032791328,
0.00745008,
0.016505426,
-0.013733941,
0.007237416,
-0.022734405,
0.0015478124,
0.015860574,
0.00869176,
-0.020799855,
0.00004933384,
0.016066378,
-0.01366534,
-0.036962274,
-0.005865394,
0.015709653,
-0.022624644,
0.008966165,
-0.05526505,
0.020182444,
0.010413648,
-0.014186708,
0.006266711,
-0.007203116,
0.0065548355,
0.0072648567,
0.007957728,
0.026356544,
-0.029882642,
0.00034493493,
-0.002124919,
0.0020614632,
-0.015407808,
-0.026411425,
0.037950132,
-0.003604988,
0.01804209,
0.0042258278,
-0.0020957638,
-0.022199318,
0.03622138,
0.0045311027,
-0.017959768,
-0.01687587,
-0.013994625,
0.021979794,
-0.012828406,
-0.004544823,
0.007861687,
-0.02424363,
-0.0027954949,
-0.004146937,
0.0058756843,
-0.018453697,
-0.015915455,
0.0422034,
0.01671123,
0.01672495,
-0.033943824,
-0.03789525,
-0.037044596,
0.0018556599,
-0.008458516,
-0.010132383,
-0.019647356,
-0.009652175,
0.008437935,
-0.00070873514,
0.024051547,
-0.0014123252,
-0.0036324284,
-0.029498475,
-0.02488848,
0.0016129834,
0.008595718,
-0.0046408647,
-0.0021540746,
-0.014543434,
0.02488848,
0.0074775205,
0.0007769075,
0.008581998,
0.02180143,
-0.0065136747,
-0.03109002,
-0.00867804,
0.010969317,
-0.031035138,
-0.0043321596,
0.014666916,
-0.008760361,
-0.0011756514,
0.0071825357,
-0.01672495,
0.0100157615,
-0.0022878468,
0.0009672756,
-0.0025742564,
0.013349774,
0.00044419215,
-0.012615743,
0.010420508,
0.008410496,
0.004146937,
-0.015009921,
0.021005658,
-0.017603043,
-0.016299622,
0.0142004285,
0.007388339,
-0.00023088559,
0.026274223,
0.024065267,
0.010585151,
-0.0060437573,
-0.010736072,
0.005354316,
0.019702237,
0.002732039,
0.0035672574,
0.00216951,
-0.026877912,
-0.010790953,
0.006774359,
-0.02247372,
-0.026548628,
-0.019016227,
0.018439976,
0.024037827,
0.014941321,
-0.026507467,
0.00039016877,
0.00094755273,
0.024271071,
-0.005669881,
-0.0061809593,
-0.021924913,
0.015188284,
0.01304793,
0.002912117,
0.0052994355,
0.00037944986,
0.033614542,
0.0212389,
0.010283305,
-0.03858126,
0.04788357,
-0.0025725414,
0.0026600077,
-0.0074226395,
-0.015078522,
-0.010276445,
-0.004088626,
-0.0064930944,
0.008911284,
-0.01120256,
0.005114212,
0.105261534,
0.0087329205,
0.0065651257,
0.01061945,
-0.02546473,
0.0018127841,
-0.007779365,
0.008431076,
-0.020813575,
-0.03811477,
0.009830538,
-0.005093632,
0.0057590627,
-0.031227222,
-0.01496876,
-0.0008343609,
-0.019029947,
0.028949665,
-0.0039274134,
-0.033285256,
0.00496672,
-0.005347456,
0.012073794,
-0.002735469,
-0.019551314,
0.006287291,
0.021979794,
-0.0025159456,
0.014323911,
-0.05282285,
-0.01118884,
0.020237325,
-0.02922407,
-0.003604988,
0.0065136747,
0.009158247,
0.002680588,
0.00034450617,
0.0075735617,
0.0008103505,
0.01616242,
0.028922224,
-0.026891632,
-0.014172988,
-0.011929732,
0.008533977,
-0.030047283,
-0.03111746,
-0.020470569
] |
Healthy cells utilize intricate systems to monitor their environment and mount robust responses in the event of cellular stress. Whether stress arises from external insults or defects due to mutation and disease, cells must be able to respond precisely to mount the appropriate defenses. Multi-faceted stress responses are generally coupled with arrest of growth and cell-cycle progression, which both limits the transmission of damaged materials and serves to reallocate limited cellular resources toward defense. Therefore, stress defense versus rapid growth represent competing interests in the cell. How eukaryotic cells set the balance between defense versus proliferation, and in particular knowledge of the regulatory networks that control this decision, are poorly understood | [
-0.022505771,
-0.0134585565,
0.0046259663,
-0.022664262,
-0.018952923,
0.015188754,
0.0063561634,
0.0077726794,
-0.0070330533,
-0.013617048,
0.011959492,
-0.00039003728,
0.00026332677,
-0.0020686423,
-0.016298193,
0.0032144026,
0.053332336,
-0.0039920006,
-0.013630255,
0.012983083,
-0.016839705,
0.014554788,
-0.00022845042,
-0.015254792,
-0.0025589748,
0.022862377,
0.009813256,
-0.019652927,
0.0019547266,
-0.02903033,
-0.0019349152,
-0.016958574,
-0.0051707802,
-0.014224598,
-0.01792273,
-0.023086905,
0.006342956,
-0.019217076,
0.02588692,
-0.011332131,
0.010242503,
0.00890193,
-0.0059170104,
-0.0043717194,
0.0120387385,
0.008175512,
0.0078056986,
-0.0017962352,
-0.017658576,
0.0154396985,
0.03600395,
0.01775103,
-0.025702013,
0.0083604185,
-0.030060524,
-0.016245363,
-0.006161351,
-0.003879736,
-0.0031747797,
-0.010467033,
-0.027181266,
-0.009813256,
-0.014871771,
0.025847297,
-0.00176982,
0.0043717194,
0.011801002,
0.0117745865,
0.0012811384,
-0.002314634,
0.020722743,
0.011041564,
-0.00360898,
0.020920858,
-0.012309494,
-0.03058883,
-0.006425503,
-0.008525513,
0.009529292,
0.016549138,
0.0071717333,
-0.023351058,
-0.002487984,
0.016734045,
-0.0036353953,
-0.007838718,
-0.015835926,
-0.007112299,
0.0057254997,
-0.0025094463,
-0.00917929,
0.025741635,
0.00033122214,
0.0049165334,
-0.010136842,
0.003952378,
0.00435521,
0.02278313,
0.009634953,
-0.03529074,
-0.006699561,
0.0017301972,
-0.0092057055,
-0.018068014,
-0.01775103,
-0.0073632435,
0.02140954,
0.006267012,
-0.00048414152,
-0.025173709,
-0.03927944,
-0.0052830447,
-0.032834124,
-0.03135487,
0.03064166,
0.012263267,
0.024209553,
-0.0034603945,
-0.03153978,
-0.0097868405,
0.007832114,
0.0011317272,
0.014396297,
-0.033547334,
0.027947307,
-0.009555708,
-0.007620792,
0.0027438814,
-0.024037855,
0.0020818498,
-0.001806141,
0.005623141,
0.0050089867,
0.0126264775,
-0.015532152,
-0.013319877,
-0.0052863467,
-0.007528339,
-0.0048967223,
-0.013399122,
0.02871335,
0.022796338,
-0.020762365,
-0.00091710355,
-0.0032886954,
0.022307657,
0.029796373,
0.033098277,
-0.012837799,
0.017275557,
-0.0012159258,
-0.010169861,
0.024328422,
-0.012870817,
0.00070536905,
0.02356238,
-0.02715485,
0.0040382273,
-0.02937373,
-0.020062363,
0.03917378,
-0.0052929507,
0.0134519525,
0.013841578,
0.0015601491,
0.02781523,
0.0065905983,
0.02621711,
0.010737789,
0.0028099194,
-0.008413249,
0.015030262,
-0.0072047524,
0.024803896,
-0.013068932,
0.009852879,
0.00042140536,
0.024354836,
-0.02632277,
-0.011741567,
-0.009694387,
0.013121762,
0.025398238,
0.006967015,
-0.00037909974,
0.019573681,
0.033230353,
0.008723628,
0.01247459,
0.0044443617,
-0.0134651605,
0.009707595,
-0.026454847,
-0.016073665,
-0.63650125,
-0.023575587,
0.0134585565,
0.009185894,
-0.010242503,
0.040547367,
0.017103858,
-0.010381183,
-0.033917148,
0.006290125,
-0.01061892,
0.0015799606,
-0.00049280905,
-0.02146237,
-0.026692584,
-0.03640018,
-0.018384997,
-0.023139736,
0.010830242,
-0.010130239,
-0.016284985,
0.0053292713,
-0.021634068,
0.0067127687,
-0.017407633,
0.030219017,
0.024354836,
0.0040019066,
0.009846275,
0.053279508,
-0.006669844,
0.01247459,
0.009258536,
0.013379311,
0.052011576,
0.024909556,
-0.011596283,
0.036849238,
0.03008694,
0.0289775,
-0.0027735985,
0.0036453009,
0.015690643,
-0.014409505,
-0.013161385,
0.019771796,
0.008611363,
-0.012190626,
0.013630255,
-0.0018903394,
0.011424584,
0.021832183,
-0.007693434,
0.020524628,
0.037456788,
0.017790653,
0.025847297,
-0.017354801,
0.002043878,
0.003925963,
0.00688777,
0.029717127,
-0.013445349,
-0.0068943733,
-0.02947939,
0.019362358,
-0.026058618,
-0.0016757158,
0.0077000377,
0.00032111007,
0.019441605,
0.014567996,
-0.020154815,
0.00060135906,
0.0045070974,
0.028185043,
0.01709065,
-0.009034007,
0.006531164,
0.051034212,
0.005068421,
-0.02123784,
-0.022439733,
0.017988767,
0.008974573,
-0.014647242,
-0.017737823,
0.023509549,
-0.013359499,
0.004226436,
0.0018655752,
-0.00088243355,
-0.006399088,
-0.04625306,
-0.0036915275,
0.017235933,
-0.018213296,
-0.015941588,
0.009370801,
-0.013590633,
-0.013973653,
-0.011100998,
-0.009535896,
0.016258571,
0.0071585258,
0.013432141,
-0.04506437,
-0.009747217,
0.040283218,
-0.009093441,
0.02892467,
0.0073038093,
-0.017737823,
0.0074028666,
0.008050039,
-0.016007626,
0.031407703,
0.025094463,
0.0025639278,
-0.020471798,
0.016020833,
-0.016496308,
0.01280478,
-0.038645472,
0.019058583,
0.012084965,
0.0041703037,
-0.019296322,
-0.010817034,
-0.002524305,
0.00735664,
-0.006706165,
0.03352092,
-0.015901964,
0.0032771388,
0.011807605,
0.0036717162,
-0.004143888,
0.0036320933,
-0.037430372,
-0.020049155,
-0.020617083,
-0.0053160638,
-0.00688777,
-0.014832148,
0.0048868163,
-0.022254827,
-0.0164831,
0.004777854,
-0.0053193658,
0.00070578174,
0.005616537,
-0.020775573,
-0.0030724208,
0.010017973,
0.003433979,
-0.009476461,
-0.03064166,
-0.007898152,
-0.011233074,
0.014779318,
0.008201927,
-0.017513294,
0.01537366,
-0.013669878,
0.0021346803,
-0.010282126,
0.0021214727,
0.003883038,
-0.03949076,
-0.008228342,
-0.017169897,
-0.012679308,
0.027894476,
0.020379346,
0.0051245536,
-0.013207612,
0.012983083,
-0.024896348,
-0.01308214,
0.0058080475,
-0.023509549,
-0.005411819,
-0.0050221942,
0.020524628,
0.024539743,
0.04955496,
-0.0047052116,
0.0120387385,
0.037245467,
0.028396366,
0.018345373,
-0.01443592,
0.011008545,
-0.0022997754,
-0.04221153,
-0.0010227645,
0.003978793,
0.016509514,
0.043479457,
0.012375533,
-0.031619024,
-0.00055760884,
-0.021171803,
0.019652927,
-0.011213263,
-0.0069273924,
-0.009192498,
0.013517991,
-0.0077462643,
-0.007191545,
0.009582123,
-0.0047514383,
0.0056627635,
0.010599108,
0.016747251,
-0.0069604116,
0.014937809,
-0.015756682,
-0.0038995475,
0.010777411,
-0.018952923,
0.034868095,
-0.0062075774,
-0.0069339965,
0.03671716,
-0.015994418,
0.032120913,
-0.009258536,
0.00504861,
0.0067887125,
0.0000073776896,
-0.0058047455,
-0.01009722,
0.0030030808,
0.03214733,
0.010724581,
-0.0045401165,
0.036743578,
0.012494401,
0.0017747729,
-0.0046226643,
0.0021198217,
0.020088777,
0.0061151246,
0.00058484956,
0.04065303,
0.0012860912,
-0.030536,
-0.014462335,
-0.013854785,
0.00008848068,
-0.02278313,
-0.004120775,
-0.0031516664,
-0.0033200635,
0.010717977,
0.006171257,
0.038539812,
0.0051509687,
0.012751949,
-0.010229295,
-0.0031566194,
0.0061151246,
0.01103496,
0.012012323,
-0.007211356,
-0.01443592,
-0.01308214,
0.0046226643,
-0.009344386,
0.0047085136,
0.0037146409,
-0.006782109,
0.0024648707,
0.014356675,
0.03156619,
-0.009159479,
0.021700107,
-0.0012217041,
-0.012685912,
0.0014363278,
0.026811453,
0.032702047,
-0.0022634545,
-0.018952923,
-0.026639754,
0.007105695,
0.008842496,
0.014554788,
-0.017235933,
0.010387787,
-0.0009996512,
-0.01332648,
-0.016007626,
-0.0013513038,
0.0007986478,
-0.021554822,
0.027630324,
0.007997209,
0.02942656,
0.001514748,
-0.008842496,
0.01443592,
0.016218947,
0.009694387,
-0.0030014298,
-0.013841578,
-0.004503796,
-0.038302075,
-0.007838718,
-0.0018160467,
-0.0013380962,
-0.01736801,
0.0064948434,
0.018134052,
-0.00092205644,
-0.002382323,
0.025543522,
0.0057486133,
-0.005659462,
-0.03241148,
-0.020471798,
-0.030403923,
0.04728325,
0.012131192,
0.002965109,
0.014911394,
-0.006068898,
0.012032134,
0.010017973,
-0.03286054,
0.028845424,
-0.037641693,
-0.019428397,
-0.0038500188,
0.005438234,
0.00034504887,
0.009833067,
0.015505737,
0.009357593,
0.0017896314,
-0.025371823,
0.021039726,
0.035132248,
-0.01598121,
0.03412847,
0.045275696,
0.021885013,
0.022135958,
-0.018451033,
0.010354768,
-0.014792525,
0.015888758,
-0.0128906295,
0.023549173,
0.021277463,
0.012877421,
-0.020128401,
0.016522722,
0.002346002,
0.0026894,
0.01377554,
0.008875515,
0.018503865,
-0.014422712,
0.013042517,
0.005850972,
0.01415856,
0.0028412875,
0.011893455,
0.022241618,
-0.010850053,
-0.0076141884,
0.018464241,
-0.029083163,
-0.0024714745,
-0.01941519,
0.013154781,
-0.0032177044,
-0.004292474,
-0.014462335,
-0.0150963,
-0.013260443,
-0.014911394,
-0.005075025,
0.014118937,
-0.0028677029,
-0.009707595,
0.01903217,
0.008472683,
-0.002854495,
-0.020049155,
-0.0072906017,
-0.010262314,
-0.044324744,
-0.018437827,
0.012032134,
0.018279335,
0.01020288,
0.0074821124,
-0.017817069,
-0.0092189135,
0.0080830585,
0.0044806823,
-0.024856726,
-0.017790653,
-0.04625306,
-0.011530246,
0.013392518,
0.006980223,
-0.009291555,
-0.00066863536,
0.0021198217,
-0.006947204,
-0.02323219,
-0.008598155,
-0.024803896,
-0.022703884,
0.0072972057,
0.026560508,
0.008829288,
0.009621745,
-0.0023971815,
0.002651428,
-0.025345407,
-0.03214733,
-0.01582272,
0.0044113426,
-0.024698235,
-0.0097802365,
0.019864248,
0.008426457,
-0.016443476,
0.022875585,
-0.022690678,
0.0042165304,
-0.006920789,
-0.00087335333,
0.02106614,
0.009694387,
0.012342514,
0.0071651293,
0.003062515,
-0.0069868267,
-0.03256997,
0.015518944,
-0.011629302,
-0.028898256,
0.015730266,
-0.0024434081,
-0.02560956,
-0.009436838,
-0.0032853936,
-0.03164544,
0.012732138,
0.008492495,
-0.047917217,
-0.011536849,
0.0058344626,
-0.016628383,
0.018226504,
-0.005408517,
-0.023271812,
-0.024288798,
0.006666542,
-0.014647242,
-0.025820881,
0.032543555,
-0.034973755,
-0.011939681,
0.005108044,
0.0016542535,
0.02500201,
-0.010381183,
-0.012633081,
-0.016786875,
0.029347314,
-0.023113322,
-0.05658141,
-0.0010153352,
-0.0036486029,
0.05520782,
0.017909521,
0.009331178,
-0.009146271,
0.0059170104,
0.013346292,
0.0038929437,
-0.022928415,
-0.01164251,
0.005979746,
-0.008261361,
0.021581238,
0.01802839,
0.014858563,
-0.017737823,
0.005137761,
0.001054958,
0.027471833,
-0.004933043,
-0.015479322,
-0.02538503,
-0.02958505,
-0.024275592,
0.033309598,
-0.012771761,
0.0038665284,
-0.02024727,
-0.012930253,
-0.007931171,
0.021198217,
0.0026844472,
-0.0014396297,
0.015188754,
-0.029743543,
0.010962318,
-0.014462335,
0.010850053,
-0.018107636,
-0.018992547,
-0.0013496529,
-0.0060061617,
0.019613303,
0.016364232,
0.020696327,
0.0020174626,
0.0012472939,
-0.018781224,
-0.0014850309,
-0.022743508,
-0.03706056,
-0.006643429,
-0.020683121,
-0.013372707,
0.02217558,
-0.008168908,
-0.009040611,
-0.015849134,
-0.0044443617,
-0.025517106,
0.0083538145,
-0.016839705,
-0.0060028597,
0.01731518,
-0.0025408145,
0.019269906,
-0.02958505,
0.031909592,
0.02080199,
-0.0035363382,
0.0022832658,
-0.035924703,
-0.002347653,
-0.0004552499,
0.04324172,
-0.014132145,
-0.0106255235,
0.007970794,
-0.021171803,
0.009641557,
-0.018490657,
-0.013696293,
0.01230289,
0.036083195,
0.0035660553,
-0.012567042,
-0.009714198,
-0.018041598,
-0.0065245605,
0.016839705,
0.012316098,
0.009654764,
-0.022268035,
-0.014000068,
0.026071826,
-0.0097802365,
0.012586854,
0.0055901217,
-0.0062472005,
0.002859448,
-0.021158595,
0.0061646528,
-0.0037575655,
0.0012018927,
0.016218947,
0.010500051,
-0.0035924704,
0.028026553,
-0.004196719,
0.014422712,
0.005576914,
0.0060821055,
0.043875687,
-0.018107636,
0.0065245605,
0.0036254895,
-0.0023922287,
0.024526535,
-0.0012571996,
0.0035759609,
0.011067979,
-0.02958505,
0.0095425,
0.016866121,
0.018503865,
-0.0150963,
-0.027788816,
-0.019296322,
-0.0015543709,
-0.026507678,
-0.02815863,
0.0148849785,
-0.0075415466,
-0.030615244,
-0.0021313783,
0.008525513,
0.03336243,
-0.0025969467,
0.0070330533,
-0.008875515,
0.032939784,
-0.015915172,
0.041049257,
-0.005712292,
-0.0031467136,
-0.025952958,
0.04392852,
-0.012210437,
-0.034022808,
0.0052236104,
-0.020815197,
-0.032886952,
-0.010229295,
-0.008459476,
-0.000552656,
0.014937809,
-0.0009451697,
0.0022403412,
0.0033299692,
0.017658576,
-0.018186882,
-0.01736801,
0.0038962455,
0.0027835043,
0.007000034,
0.0393851,
-0.03550206,
-0.000645522,
0.012771761,
-0.019283114,
0.006782109,
-0.0010533071,
-0.031619024,
-0.044932295,
0.01764537,
-0.012454778,
0.002484682,
-0.0012514213,
-0.019151038,
-0.0038962455,
0.004332097,
0.002859448,
-0.0052500255,
-0.01341233,
-0.0061052185,
0.034973755,
0.016575553,
-0.014515165,
0.015743474,
-0.008195323,
-0.01797556,
-0.023417097,
-0.003308507,
-0.00014094998,
0.04506437,
0.017500086,
0.015862342,
-0.026520886,
0.011649114,
-0.024143515,
-0.03605678,
0.00073384796,
0.02333785,
0.01658876,
0.021594446,
0.0050948365,
0.0151623385,
0.0028825614,
0.010566089,
-0.004995779,
-0.004639174,
-0.009007592,
-0.025754843,
0.01681329,
0.0025061443,
-0.022149166,
-0.021581238,
0.028449196,
-0.008736836,
-0.00782551,
0.011662321,
0.0022205298,
0.020154815,
0.0012217041,
0.013920823,
0.0025573238,
0.0138812,
0.026983151,
-0.013306669,
-0.004731627,
0.029717127,
0.0057981415,
-0.0097868405,
0.016271777,
0.00912646,
-0.0020224156,
0.0061778603,
-0.00023897523,
-0.033705827,
-0.00037621058,
-0.013115158,
0.010592504,
0.009879294,
0.0053127618,
-0.0025408145,
0.012051946,
-0.012732138,
-0.017777447,
-0.031698268,
-0.023773702,
-0.010592504,
-0.0026728904,
-0.004292474,
-0.017064234,
0.0030658168,
-0.003133506,
-0.0070726764,
-0.020920858,
-0.025900127,
-0.00019780462,
-0.033547334,
0.016707629,
0.012652893,
-0.0021941145,
-0.016417062,
0.016284985,
-0.012190626,
-0.026679376,
-0.0006277743,
0.005236818,
-0.0031236003,
0.010803826,
-0.008703817,
0.00449389,
-0.0014033088,
-0.015413283,
-0.011708548,
-0.008743439,
0.009905709,
0.19991042,
-0.018213296,
0.0114840185,
0.028185043,
0.011906662,
-0.0044608708,
-0.00093361305,
-0.011173639,
-0.0071585258,
0.028079383,
0.0048108725,
0.00092040544,
0.008862307,
0.0077462643,
0.026349185,
-0.0038896417,
-0.028132213,
0.012177418,
-0.0055967257,
0.009892501,
0.0092189135,
-0.02162086,
0.0038368113,
-0.0059995577,
0.0482342,
0.009469857,
-0.023245398,
-0.005761821,
0.022083128,
-0.022386903,
-0.01466045,
0.006227389,
0.007046261,
0.015069885,
0.016311402,
0.0019349152,
-0.020049155,
0.0049594585,
0.006329748,
-0.030826567,
0.0031467136,
0.010645336,
0.002623362,
0.016509514,
0.015149131,
0.000902245,
-0.017275557,
-0.01238874,
0.0032226574,
-0.00992552,
-0.05253988,
0.0032820916,
-0.0067358823,
0.03135487,
0.005659462,
-0.00006412915,
0.0024037855,
-0.013986861,
-0.010750996,
0.011913266,
-0.019705757,
-0.006290125,
-0.043558706,
0.0126132695,
-0.019996325,
0.02781523,
-0.025873711,
0.008340607,
-0.003098836,
-0.0049165334,
-0.024288798,
-0.019837834,
-0.014858563,
0.0046028527,
-0.0041769072,
0.01280478,
0.021105764,
0.0019877455,
0.007046261,
0.0069934307,
0.0091991015,
-0.0057684244,
-0.03484168,
0.002114869,
0.016007626,
-0.038539812,
0.027973723,
0.011153828,
-0.027234096,
-0.008373626,
0.002002604,
0.0076736226,
-0.020432176,
-0.0029766655,
0.022215204,
-0.010084012,
0.010605712,
0.015056678,
-0.01587555,
-0.019322736,
-0.04353229,
0.08785704,
0.010387787,
0.012685912,
0.0026894,
0.0047118156,
-0.020234061,
0.019098207,
-0.016271777,
-0.012296286,
-0.0051179496,
-0.024843518,
0.015003847,
-0.0037938866,
-0.01979821,
0.014700072,
0.014066107,
-0.025517106,
0.047151174,
-0.0293209,
0.00456323,
-0.017671784,
0.0107576,
0.0038599246,
0.009648161,
0.007924567,
-0.029690713,
-0.0027438814,
0.01327365,
-0.03634735,
-0.004995779,
-0.005108044,
-0.0039589815,
0.0114774145,
-0.0004131506,
-0.008802873,
0.031169964,
-0.01863594,
-0.009172686,
0.00829438,
-0.012712327,
-0.0043221912,
0.006092011,
0.027445417,
0.0023113322,
-0.00428587,
0.019507643,
0.021369915,
-0.010420806,
-0.014079315,
0.0005613235,
-0.007832114,
-0.014924602,
-0.0241171,
0.0032193554,
-0.027366173,
-0.0062438985,
-0.0009996512,
0.013735916,
0.00050642935,
-0.030720906,
0.016681215,
0.011094394,
-0.017117064,
-0.0024962386,
0.0008931648,
-0.16504233,
0.03650584,
0.027577493,
-0.01327365,
0.014369882,
0.024209553,
-0.013002894,
0.016575553,
-0.021885013,
0.016218947,
0.025754843,
-0.012573646,
-0.026349185,
-0.0189133,
-0.007739661,
-0.015083093,
0.018147258,
0.023932192,
0.012593458,
0.009707595,
0.0065212585,
-0.0253322,
0.002823127,
-0.01565102,
0.020101985,
0.02140954,
0.006290125,
0.003978793,
-0.011662321,
-0.018741602,
-0.0086443825,
0.0042627566,
-0.0029419956,
0.007211356,
-0.008109474,
0.0021033122,
-0.008300984,
-0.011398169,
-0.007713245,
0.01098213,
0.032279402,
0.01565102,
0.009304763,
0.012368929,
-0.008400042,
0.05021534,
-0.008578344,
-0.0059071044,
0.008664194,
-0.019771796,
0.023403889,
-0.008426457,
-0.0073962626,
0.019718966,
0.015122715,
-0.0027042585,
0.005405215,
0.009529292,
0.008954761,
-0.0074821124,
-0.015334037,
-0.017275557,
0.0418153,
0.0060028597,
-0.0013331433,
-0.026190694,
-0.009575519,
0.020551044,
-0.024843518,
0.014198183,
-0.011015149,
-0.020683121,
0.017790653,
-0.024751065,
0.010493448,
0.0017153386,
-0.0046556834,
-0.0069273924,
-0.028528443,
0.0074292817,
-0.008373626,
-0.0052929507,
-0.011708548,
-0.040468123,
-0.015215169,
0.012117984,
0.0050122887,
0.02760391,
0.0005233516,
0.011160432,
0.018160466,
-0.012428363,
-0.01974538,
-0.015968002,
0.027841646,
0.013854785,
0.015703851,
-0.002281615,
-0.014224598,
0.016060457,
0.007653811,
-0.01471328,
-0.018147258,
0.010414202,
0.01158968,
-0.0032573272,
0.0021313783,
-0.023826532,
0.04065303,
0.0036948295,
-0.016496308,
0.010764204,
0.011411377,
0.019018961,
-0.004335399,
0.025424654,
0.025490692,
-0.0017566124,
-0.0007449919,
-0.049528547,
0.076075844,
0.006366069,
-0.03449828,
0.0126132695,
0.0027389284,
-0.031117134,
-0.14221957,
-0.022954829,
0.0059764446,
0.016007626,
0.01537366,
0.029769957,
-0.011847228,
0.026534092,
-0.006039181,
0.029109577,
-0.024685027,
-0.003975491,
-0.008485891,
-0.014475543,
-0.0066566365,
-0.0059071044,
0.007984001,
-0.009991558,
-0.02101331,
0.02240011,
0.002415342,
-0.017473672,
-0.008888723,
-0.00796419,
0.013035913,
0.02167369,
-0.03893604,
0.018292543,
0.01643027,
0.016403854,
-0.0036486029,
0.014858563,
0.020986896,
-0.01963972,
0.00018717663,
-0.0024731252,
-0.018384997,
-0.020762365,
0.015915172,
-0.023720872,
-0.006058992,
0.00496276,
0.04070586,
-0.013815162,
0.00442455,
-0.012203833,
-0.011801002,
-0.0005642127,
0.011708548,
-0.009753821,
-0.033415258,
-0.016126495,
-0.0281058,
-0.019256698,
0.0154396985,
-0.01542649,
0.018754808,
0.026534092,
-0.011437792,
0.01896613,
0.013788747,
0.0060788034,
-0.010136842,
-0.006739184,
0.026758622,
-0.026507678,
-0.034366205,
-0.010348164,
0.02710202,
-0.020115193,
0.011114205,
-0.005438234,
-0.005550499,
0.009113252,
-0.018279335,
0.023549173,
-0.019164246,
-0.009727406,
0.0011284254,
0.0024929368,
0.008201927,
-0.014409505,
0.008664194,
-0.03275488,
0.02344351,
-0.015862342,
-0.0151755465,
-0.005487763,
0.0023080301,
-0.0083604185,
-0.018517071,
0.021092556,
0.005814651,
0.001771471,
-0.0046028527,
0.0073764515,
0.00524012,
0.0048207785,
0.007389659,
0.020656705,
-0.008406645,
0.0013694642,
-0.02599258,
0.0074755084,
0.0083472105,
0.0164831,
-0.00017747728,
0.00068101747,
-0.0005918661,
-0.015941588,
0.02399823,
0.029215237,
-0.0072972057,
-0.008717024,
0.03407564,
-0.027683156,
-0.031777516,
-0.016694421,
0.006428805,
-0.017328387,
0.00037724242,
0.027920892,
-0.013260443,
-0.013762332,
0.02998128,
0.0010937554,
0.004688702,
-0.01676046,
-0.006293427,
0.010407599,
-0.017434048,
-0.03196242,
0.02566239,
-0.024579367,
-0.024671819,
0.008195323,
-0.01719631,
-0.025252955,
-0.012745346,
0.04273983,
0.00857174,
0.019269906,
-0.020168023,
-0.04015114,
0.00006706991,
-0.022254827,
-0.028052967,
0.0018011881,
-0.06366069,
0.00011474113,
0.0028049666,
-0.016549138,
0.047336083,
0.0058278586,
-0.011384961,
-0.033996392,
-0.006088709,
0.004665589,
-0.018015184,
-0.0040217177,
0.005477857,
-0.015479322,
-0.009905709,
0.029109577,
0.013227424,
0.012236852,
-0.002856146,
-0.015360453,
-0.01847745,
-0.010975526,
-0.014554788,
-0.027419003,
0.005322668,
-0.002246945,
0.008756647,
-0.00829438,
0.004731627,
-0.00598635,
-0.014528373,
0.007211356,
-0.01681329,
0.031328455,
0.013722708,
-0.0007945204,
-0.012461382,
0.012355721,
0.040441707,
-0.012131192,
-0.013128366,
0.03518508,
0.020049155,
-0.0002783917,
-0.0043387003,
0.013009498,
0.0065443716,
0.009238725,
0.034022808,
0.0329662,
-0.02217558,
0.025213331,
0.0072906017,
0.032015253,
0.0070594684,
0.004143888,
0.0053887055,
-0.016166117,
0.0007441664,
0.010784015,
-0.008670798,
-0.013537803,
-0.02626994,
0.015783096,
-0.0047547403,
0.007818907,
-0.003572659,
-0.0068745622,
-0.020617083,
0.009106648,
0.0041835112,
0.014369882,
0.002346002,
0.024275592,
0.014475543,
0.012784968,
-0.017169897,
-0.0056429524,
0.022347279,
0.013313273,
0.015558567,
-0.016298193,
0.007898152,
0.0022007183,
0.03518508,
0.0039094533,
-0.04081152,
-0.022928415,
0.021488784,
-0.024764273,
0.0126198735,
0.029056747,
-0.035264324,
0.06720033,
0.0176982,
-0.018041598,
0.00912646,
-0.00013548121,
0.027234096,
0.0009831416,
-0.000293663,
0.004975968,
-0.02576805,
0.033943564,
0.0046028527,
0.0023410493,
-0.020775573,
0.00033039667,
0.057004053,
-0.02339068,
0.0032276101,
-0.005765123,
-0.0062505025,
0.029505806,
-0.01724914,
0.003843415,
0.014013276,
-0.023258604,
-0.013359499,
0.021501992,
-0.0008510655,
0.00890193,
-0.024381252,
0.0062207854,
0.002251898,
-0.03196242,
-0.0073698475,
0.005992954,
0.009073629,
-0.013379311,
-0.011213263,
-0.0034835075,
0.011173639,
-0.009271744,
0.018979339,
-0.024856726,
-0.0253322,
-0.021105764,
0.000842398,
-0.0065972023,
-0.008617966,
-0.01537366
] |
The forkhead O (FoxO) family of transcription factors participates in diverse physiologic processes, including induction of cell-cycle arrest, stress resistance, differentiation, apoptosis, and metabolism. Several recent studies indicate that FoxO-dependent signaling is required for long-term regenerative potential of the hematopoietic stem cell (HSC) compartment through regulation of HSC response to physiologic oxidative stress, quiescence, and survival. These observations link FoxO function in mammalian systems with the evolutionarily conserved role of FoxO in promotion of stress resistance and longevity in lower phylogenetic systems. Furthermore, these findings have implications for | [
-0.012689956,
-0.013050808,
0.002525963,
-0.019312255,
-0.031086717,
0.0056700516,
-0.022666842,
0.027224267,
-0.009943473,
-0.019272162,
0.028119713,
-0.0063550016,
0.02280049,
0.00046651793,
-0.023147978,
-0.011721002,
0.033679504,
-0.017882213,
0.0036085183,
0.0046509793,
-0.016291792,
0.028146444,
-0.023027694,
-0.01543644,
-0.00082319323,
0.019713202,
0.001333147,
-0.028921606,
0.004176526,
-0.038277023,
0.011921476,
0.009930108,
-0.00941556,
0.010417926,
-0.0057903356,
-0.023214802,
0.0002986216,
-0.023281626,
0.00009209239,
-0.014353884,
0.024845317,
0.017427808,
-0.008312957,
0.0008896,
0.0032175956,
0.007985517,
0.00026917708,
-0.018670741,
-0.0023355132,
0.03271723,
0.011360151,
0.01663928,
-0.007631348,
0.0029335918,
0.006344978,
-0.003892522,
0.024925506,
0.011320055,
0.013966302,
-0.013625498,
-0.0005462896,
-0.0038190153,
-0.022466367,
0.012603085,
-0.008393146,
0.024511196,
0.004313516,
0.021357082,
-0.0046977564,
0.012121948,
0.04370317,
0.01201503,
-0.027504928,
0.014728101,
0.015302791,
-0.016933307,
-0.047151305,
0.008099119,
0.013197822,
0.00031950424,
0.014768195,
-0.02953639,
-0.0031290532,
0.031354014,
0.017213969,
0.00095642445,
-0.024831953,
0.012603085,
-0.000017032395,
0.011694272,
0.0032025601,
0.013979668,
0.023909776,
0.00656884,
-0.010023662,
0.010070439,
0.003511623,
0.02849393,
-0.011353468,
-0.025660574,
-0.012977301,
0.009669493,
-0.010143946,
-0.012516213,
-0.026328819,
-0.0024758445,
0.0109057445,
0.015543358,
-0.00077391026,
-0.0046543204,
-0.036753427,
0.03849086,
-0.017467901,
-0.038170107,
0.022038693,
-0.012943889,
0.020996232,
0.010417926,
-0.029563121,
0.00583043,
0.039773893,
0.03536348,
0.010952521,
-0.028387012,
-0.0055497675,
0.010491433,
0.0028734498,
0.01201503,
-0.017147144,
-0.010711954,
0.015636913,
-0.021811489,
0.019365715,
0.0044738944,
-0.0367267,
0.0082862275,
-0.024484465,
-0.012730051,
-0.012108584,
-0.026021427,
0.017160509,
0.014220235,
-0.005526379,
-0.0019278843,
-0.0065387688,
0.0034314336,
0.023415275,
-0.0026128346,
0.009575939,
0.0056266156,
0.014781561,
-0.009408877,
0.04552079,
-0.0024357499,
0.0056900987,
0.023722667,
0.021330353,
0.032770693,
-0.011039393,
-0.027825685,
0.009295276,
-0.02107642,
0.0046910737,
0.010932474,
-0.011847968,
0.003035499,
0.014353884,
0.018443538,
0.017254064,
-0.0030421815,
0.0056132507,
0.014768195,
-0.029108714,
0.019526094,
0.0011710979,
0.012108584,
-0.007912011,
0.013491849,
-0.025192805,
-0.004256715,
-0.00856689,
0.010598352,
0.012803557,
0.0008637055,
-0.022934139,
0.009836554,
0.024778493,
-0.015877482,
0.00067242066,
-0.00941556,
0.008353052,
0.008139214,
0.0037521909,
-0.0006820267,
-0.6269734,
-0.0039192517,
-0.013244599,
-0.013171092,
0.015810657,
0.032663774,
-0.001278017,
-0.0046142256,
-0.0319688,
0.021009596,
-0.014246965,
0.023388544,
0.01480829,
-0.040789623,
-0.01428706,
-0.05126769,
-0.023883045,
-0.020354716,
0.02170457,
-0.007036611,
-0.0055130143,
-0.0012128631,
-0.030391743,
0.0048815235,
0.00864708,
0.029990798,
0.044959467,
-0.01642544,
-0.00060225505,
0.026101615,
-0.006314907,
0.02630209,
-0.009342053,
0.025820954,
0.054127775,
0.008259498,
-0.019713202,
0.036192104,
0.013645546,
0.049583714,
-0.008172626,
0.016933307,
0.025406642,
-0.0034180689,
-0.024537925,
0.0019312255,
0.019713202,
0.005085338,
0.0063717077,
-0.011126265,
0.0052290102,
0.018844485,
-0.0078050913,
0.004497283,
0.0026913532,
0.0098632835,
0.028681038,
-0.018978134,
0.006722536,
0.0030455226,
0.0016689397,
0.03183515,
-0.0109057445,
-0.019098418,
0.0025242923,
0.028707769,
-0.011981618,
-0.012983983,
0.035710968,
-0.017641645,
0.017561456,
0.03188861,
-0.015449804,
0.005302517,
0.003541694,
0.037341483,
-0.0011426975,
0.008600302,
0.011046075,
0.039132375,
0.0095358435,
-0.0014066539,
-0.012115266,
0.004330222,
0.019499363,
-0.009442289,
-0.014941939,
0.014220235,
0.0020464978,
-0.012188773,
0.015529994,
-0.008379782,
-0.010478068,
-0.050893474,
-0.012910477,
0.018336618,
-0.0006511204,
0.01992704,
-0.0047178036,
-0.03752859,
-0.011841286,
0.0055196965,
0.003815674,
0.008473336,
0.000999025,
0.011340103,
-0.024658209,
-0.011126265,
0.03533675,
-0.021864949,
-0.01283697,
-0.0029987455,
-0.00021780582,
-0.003424751,
0.006976469,
-0.01940581,
0.029964067,
0.0009706246,
-0.009221769,
-0.019846851,
0.034107182,
-0.011032711,
0.010437974,
-0.015129047,
0.027986065,
0.0133582,
0.019633014,
-0.016024495,
-0.007477652,
-0.006572181,
0.0071368474,
-0.004176526,
0.010665176,
-0.03188861,
0.009168309,
-0.00023680902,
0.01363218,
0.0058671837,
0.03894527,
-0.038170107,
-0.04324876,
-0.0058972547,
0.0023288308,
-0.032556854,
-0.009315323,
-0.0027832368,
-0.008312957,
-0.0046676854,
0.028360281,
-0.0004573296,
-0.004263398,
-0.0047445334,
-0.02162438,
0.006936374,
0.018456902,
-0.013117633,
-0.00610441,
-0.019338986,
-0.0036519542,
-0.019472634,
-0.019526094,
0.0332251,
-0.012395929,
0.00052540697,
-0.030231364,
-0.020501731,
0.0045507425,
0.021584285,
0.0035550587,
-0.030578852,
-0.0039593466,
-0.033893343,
-0.012970619,
0.00010796319,
-0.007865233,
0.011667543,
-0.0010165664,
0.019739931,
-0.009174992,
-0.018096052,
-0.0063215895,
-0.02852066,
-0.028119713,
-0.018390078,
0.0090613905,
0.019392446,
0.016184874,
0.01891131,
0.008987884,
0.027852416,
-0.019071687,
0.016545724,
-0.019633014,
0.010257548,
0.0027748838,
-0.048407607,
-0.014474168,
0.0009806483,
0.01223555,
0.028253362,
0.01830989,
-0.048434336,
0.009348735,
-0.01371237,
0.02948293,
-0.009722952,
-0.004273421,
-0.020742299,
-0.012636497,
0.0062781535,
-0.010010297,
0.006191282,
-0.0032977848,
-0.008185991,
0.006615617,
-0.0036953902,
0.00002477202,
-0.003078935,
-0.002671306,
-0.037876077,
-0.0012613108,
-0.006735901,
0.009763047,
0.0029469565,
0.008419876,
0.008493383,
0.014353884,
0.0072237193,
0.021864949,
0.013157727,
-0.0046877326,
0.01026423,
-0.014661277,
0.0022402885,
0.011473752,
0.013050808,
0.01223555,
-0.021116516,
0.03076596,
-0.016625915,
0.009275229,
-0.0076380307,
0.020702204,
0.0045908373,
-0.011373515,
-0.015008763,
0.04573463,
-0.025714034,
-0.019606283,
-0.005182233,
-0.016692739,
0.0064786267,
-0.009148262,
0.011781144,
0.020862581,
0.00020454536,
-0.007831821,
-0.0011326738,
0.039159108,
0.017507996,
0.028787958,
-0.008500066,
0.0016881517,
-0.0111129,
0.000603508,
0.0050953617,
-0.0046342732,
-0.0008202697,
-0.016813023,
-0.016211603,
-0.04250033,
-0.00024077672,
0.010885697,
-0.022546558,
0.021196704,
0.016813023,
0.006081022,
0.01896477,
0.011600718,
-0.00044688827,
0.011540576,
-0.018563822,
0.022185706,
0.0169734,
-0.002551022,
0.0090613905,
-0.018122781,
-0.0065220627,
0.0053960714,
0.012101902,
0.014567723,
-0.0036419306,
-0.009890013,
-0.0037956268,
-0.012803557,
-0.011573989,
0.023508828,
-0.021611016,
0.012783511,
-0.009121533,
0.008413194,
0.0072036716,
-0.010284278,
0.005205622,
0.041110378,
0.000026573145,
0.01426033,
-0.011313373,
-0.011901428,
-0.027157443,
-0.0054562134,
-0.0075043817,
-0.0021250164,
-0.019232066,
0.015997766,
0.0027865781,
0.0065922285,
-0.0048080166,
0.023883045,
-0.0120350765,
-0.020956136,
-0.009322005,
-0.019392446,
-0.022399543,
0.03188861,
0.02277376,
-0.011246549,
0.015703738,
-0.010665176,
0.008947789,
-0.014113316,
-0.014166776,
0.017868849,
-0.015810657,
-0.013237917,
-0.0016605867,
-0.0041531376,
-0.0020615333,
-0.0062280353,
0.01937908,
0.0029035208,
-0.017855484,
-0.01650563,
-0.02008742,
-0.013004031,
-0.016706103,
0.028119713,
0.0479532,
0.031754963,
-0.0026011404,
-0.006719195,
0.060248893,
0.00042475268,
-0.013872748,
-0.0065521337,
0.0067292186,
0.002014756,
0.014340519,
0.00041264074,
-0.011039393,
0.0042767627,
0.014033127,
0.0027565071,
0.0062414003,
0.0054428484,
0.00845997,
0.021357082,
0.0044438234,
0.014073222,
-0.014955304,
-0.0029686745,
0.010665176,
-0.008700538,
-0.018523728,
0.020608649,
-0.032610316,
-0.028039524,
-0.0025159393,
0.0038056504,
-0.0022436297,
0.0062447414,
-0.003352915,
-0.009188357,
-0.001037449,
-0.021664474,
-0.024283992,
0.02548683,
0.001554503,
0.013144362,
-0.002151746,
0.0030070986,
-0.026462467,
-0.015596818,
-0.005192257,
0.026074886,
-0.016345251,
-0.028814686,
0.021864949,
0.039773893,
0.037234563,
0.011794509,
-0.036192104,
-0.0040328535,
-0.013351518,
-0.00086119963,
-0.012603085,
-0.010524845,
-0.027745496,
0.00876068,
0.0013999714,
0.0015653619,
0.0012278986,
0.005810383,
0.005071973,
0.014701371,
-0.004463871,
-0.00996352,
-0.0027748838,
-0.015877482,
0.00457079,
0.027050523,
0.024658209,
0.0015653619,
-0.0009271887,
0.0006974798,
-0.014460803,
-0.018978134,
-0.01836335,
-0.016345251,
-0.019058323,
0.004333563,
0.013144362,
-0.02342864,
-0.023963235,
0.0424736,
-0.007604618,
0.018189605,
-0.017347617,
0.0082862275,
0.0069564213,
0.012021712,
0.038303755,
0.0070299283,
-0.0052924934,
-0.015944306,
-0.019686472,
0.020675473,
0.027451469,
-0.015583454,
0.0013941244,
0.0011986629,
-0.007711537,
-0.031033257,
0.01174105,
-0.028173173,
0.026435738,
-0.013117633,
-0.013859384,
-0.009883331,
0.0033345383,
-0.017588185,
0.007831821,
0.0076513956,
-0.006027562,
-0.00003479568,
-0.006943057,
0.018991498,
-0.029108714,
0.023802856,
-0.040388677,
-0.014848385,
0.010658494,
0.019753296,
-0.002936933,
-0.0128703825,
-0.01056494,
-0.004213279,
-0.009281911,
-0.01817624,
-0.038303755,
0.005355977,
-0.03212918,
0.035523858,
0.021450637,
0.029162174,
0.026609482,
0.0047545573,
0.014313789,
-0.0031307237,
0.0035951536,
-0.0032443253,
0.002739801,
-0.0103978785,
0.006909644,
-0.0012529577,
0.0026211876,
0.020234432,
-0.0011426975,
0.00026541823,
0.041484598,
-0.018390078,
-0.02624863,
0.007009881,
-0.030231364,
-0.016118048,
0.0034915756,
-0.022760395,
-0.0046743676,
-0.027170807,
0.015570088,
0.03212918,
0.028092984,
0.0027230948,
-0.002126687,
0.010437974,
-0.016518995,
0.016813023,
-0.0067024888,
0.011366833,
-0.014353884,
0.0028584143,
0.013304741,
-0.011400245,
0.025580386,
-0.015209236,
0.018349985,
-0.012963937,
-0.017000131,
0.0058538187,
0.021905042,
-0.03517637,
-0.009395513,
-0.00036356656,
-0.027986065,
-0.004136431,
-0.010912427,
-0.00007914517,
-0.034454666,
-0.013966302,
0.025607115,
-0.025620481,
0.016666008,
-0.0049750777,
-0.0062581063,
0.042339947,
-0.0130173955,
0.027718768,
-0.0115606235,
0.03311818,
0.011654178,
0.008112484,
-0.020247797,
-0.013952938,
0.0026429056,
0.00026103287,
0.02003396,
0.024016695,
-0.0005429484,
-0.024805222,
0.0015678678,
0.0021083103,
-0.02345537,
-0.02682332,
0.0029686745,
0.0063850726,
0.015810657,
-0.010758731,
0.0019412492,
-0.019485999,
-0.0074709696,
0.013551991,
-0.0017959061,
0.0009622716,
-0.010077122,
-0.029162174,
0.028814686,
-0.0030622287,
-0.01428706,
0.016599184,
-0.017868849,
-0.0031440887,
-0.02110315,
-0.0013523591,
0.0024591384,
-0.008252815,
0.04217957,
-0.009495749,
0.02003396,
0.025446737,
0.0060175383,
-0.00415982,
-0.015797291,
0.009495749,
0.0422063,
-0.008827505,
-0.008914377,
0.008353052,
0.011794509,
-0.0027565071,
-0.010204088,
0.003454822,
-0.0016739516,
-0.03891854,
-0.00075971003,
0.025794223,
-0.0064518973,
0.005847136,
-0.009442289,
-0.023682572,
-0.018496998,
-0.03429429,
-0.038998727,
0.012877065,
-0.0367267,
-0.0037120963,
0.007818457,
0.031033257,
0.011346785,
0.019472634,
-0.017748564,
-0.00106752,
0.037448402,
-0.01825643,
0.02980369,
0.016960036,
0.0045073065,
-0.015677007,
0.02118334,
-0.006147846,
-0.0489422,
0.013572038,
-0.007584571,
-0.028092984,
0.00023305014,
0.0011034381,
0.0309798,
0.018376714,
0.00007491643,
0.0029519685,
0.019633014,
0.017588185,
-0.002778225,
-0.009729635,
0.012489483,
-0.029776959,
0.0019562847,
0.012275645,
-0.018563822,
0.001080885,
0.00006327437,
-0.002602811,
0.025607115,
0.007791727,
-0.014500898,
-0.013418342,
-0.00024725034,
-0.027077252,
0.0066423467,
-0.012342469,
-0.013157727,
-0.018122781,
0.014848385,
-0.014273695,
0.008586938,
-0.03416064,
0.0035851297,
0.008326322,
0.0023522193,
-0.008152579,
0.0049249595,
0.02559375,
-0.038250294,
-0.044157572,
-0.0058037005,
-0.009241817,
0.022974234,
0.0130775375,
-0.014126681,
-0.022573287,
-0.0070499755,
-0.030204635,
-0.017200604,
0.0011861334,
0.021544192,
-0.0032159248,
0.0052757873,
-0.007798409,
-0.0054228012,
0.0011426975,
0.01729416,
-0.010999299,
-0.0137925595,
0.00010357784,
0.012663227,
0.011139629,
-0.016732832,
-0.020782392,
-0.0037521909,
0.017000131,
-0.021771394,
0.0032393134,
0.0057736295,
-0.01650563,
0.040281758,
-0.018430173,
0.0018510362,
0.008446606,
0.025767494,
0.0063382955,
-0.01945927,
-0.00914158,
0.0133448355,
0.008780728,
-0.0032459958,
0.0009029649,
-0.017534725,
0.004423776,
0.008145896,
-0.00023618253,
-0.024872048,
0.04017484,
-0.00999025,
0.016224967,
0.02214561,
0.013752464,
0.018096052,
0.0071234824,
-0.00429681,
-0.016438806,
-0.018510362,
-0.019860215,
-0.0033813154,
-0.006802725,
-0.012816923,
-0.020929407,
-0.0027682013,
-0.0030455226,
-0.022372814,
0.008526796,
0.0016029506,
-0.011553941,
-0.03883835,
0.024805222,
-0.019058323,
-0.004480577,
-0.02058192,
0.00851343,
-0.0032459958,
-0.019205337,
0.0035617412,
-0.021784758,
-0.0028868148,
-0.008693856,
-0.0025159393,
0.003032158,
0.0010282607,
-0.025954602,
-0.021397177,
0.010952521,
0.04124403,
0.1800517,
-0.014714736,
-0.007871916,
0.0012521225,
0.023695936,
0.0017290817,
0.014273695,
-0.012997349,
0.0004128496,
0.010551575,
0.023107883,
0.0023037717,
0.02036808,
-0.00018000827,
0.02167784,
-0.021530826,
-0.0055965446,
0.022372814,
-0.019699838,
-0.00048990647,
0.019659743,
-0.011159677,
0.017213969,
-0.009876648,
0.044772357,
0.0001723861,
-0.017882213,
-0.001207016,
0.02110315,
0.018978134,
-0.02953639,
0.012081854,
-0.010357784,
0.012877065,
0.011874698,
0.00046651793,
-0.01193484,
-0.008299592,
0.009930108,
-0.0050485847,
0.017120415,
0.0065287454,
-0.012643179,
0.003872475,
0.010090486,
0.015503264,
0.00498176,
0.012643179,
-0.008907694,
-0.005817065,
-0.06655712,
0.020728933,
-0.0057903356,
0.02441764,
0.00038256976,
0.01990031,
0.010979251,
0.010163994,
-0.008961154,
0.0037154374,
-0.008693856,
-0.000613114,
-0.031354014,
0.01201503,
-0.010792143,
0.018844485,
-0.025620481,
-0.003541694,
0.009582621,
-0.0074976995,
-0.024457736,
0.011132947,
-0.012155361,
-0.0070299283,
0.002559375,
-0.018096052,
0.007464287,
0.00086955266,
0.009215087,
0.018951403,
0.0075444765,
-0.01896477,
-0.03862451,
0.017935673,
0.0039793937,
-0.022158975,
0.03974716,
0.01757482,
-0.02515271,
-0.015596818,
0.0115606235,
0.0042466917,
-0.007704855,
-0.017374348,
-0.010498116,
-0.018189605,
-0.011841286,
0.026008062,
-0.0055865212,
-0.004283445,
-0.044745628,
0.07810438,
-0.006826114,
0.020515095,
-0.010177358,
0.0060175383,
-0.023909776,
0.023107883,
-0.005315882,
-0.011473752,
0.020221068,
-0.010792143,
-0.017227333,
-0.0032894318,
-0.0044906004,
0.012977301,
0.0119482055,
-0.006344978,
0.033732966,
-0.019806756,
0.007043293,
-0.0329578,
0.0103110075,
0.02501906,
0.004193232,
-0.0074375574,
-0.015503264,
-0.008246133,
-0.012202138,
-0.034935802,
0.013846018,
-0.02058192,
0.006675759,
0.007678125,
0.0019479317,
-0.024243897,
0.003785603,
-0.012121948,
-0.01757482,
0.020916041,
-0.03525656,
-0.011159677,
0.007751632,
0.009829871,
0.000076743665,
-0.035844617,
0.022626746,
0.004099678,
-0.018938038,
-0.0050652907,
-0.017748564,
-0.00889433,
-0.01830989,
0.014353884,
0.018924674,
-0.0119883,
-0.0031925363,
-0.039773893,
0.009101485,
0.005045243,
-0.0329578,
0.019338986,
-0.0142336,
-0.019419175,
-0.014300425,
0.000484477,
-0.16807677,
-0.00881414,
0.02340191,
-0.027638577,
0.039453134,
-0.004557425,
0.00626813,
-0.0047178036,
-0.015636913,
0.017962402,
0.030471932,
0.014995399,
-0.032583583,
-0.019445904,
0.006204647,
-0.00509202,
0.012349152,
0.032182638,
-0.002181817,
0.0084065115,
0.009582621,
-0.003845745,
0.022613382,
-0.007190307,
0.0054461895,
0.021250164,
0.025420006,
-0.005920643,
-0.001877766,
-0.009569256,
-0.024898777,
-0.008426558,
0.0020414859,
-0.0009806483,
-0.023896411,
0.0035517176,
-0.0063483194,
-0.023936504,
-0.0025159393,
0.031487662,
0.023281626,
0.022533193,
-0.016118048,
0.0070499755,
-0.0056366394,
0.03191534,
-0.0045641074,
0.008493383,
0.01420687,
-0.0027364597,
0.020862581,
0.0026813296,
0.0152493315,
0.02570067,
0.010524845,
-0.018443538,
-0.0025660575,
0.009622715,
-0.00191619,
-0.0066055935,
-0.006989834,
-0.018897945,
0.028253362,
-0.0035049405,
0.010544892,
-0.034882344,
-0.013531944,
0.02614171,
-0.041778624,
-0.0002890156,
-0.0052457163,
-0.0012571343,
0.01480829,
-0.0071635772,
0.015997766,
0.011821239,
-0.01757482,
0.012796875,
0.014554357,
0.018029226,
0.014033127,
0.0029870514,
-0.025259629,
-0.028039524,
0.0046843914,
-0.0012821935,
0.004253374,
0.02225253,
-0.00014367249,
-0.001283864,
0.01937908,
-0.011326739,
-0.007932058,
-0.0054929666,
0.025139345,
0.019218702,
-0.006809408,
-0.018871214,
-0.002036474,
-0.002277042,
0.012148678,
-0.01891131,
-0.012903795,
-0.0011326738,
0.045306955,
-0.0009230122,
-0.009161627,
0.016385347,
0.054314885,
-0.005252399,
0.0022202411,
0.012683274,
0.015115682,
0.017695105,
-0.00086955266,
0.016318522,
0.01204176,
-0.0015653619,
-0.010999299,
-0.037127644,
0.08045659,
0.012963937,
-0.023214802,
0.020408176,
-0.010645129,
-0.033973534,
-0.13535953,
-0.018403444,
-0.003481552,
0.015877482,
0.0010174017,
0.024684938,
-0.0055297203,
0.02332172,
-0.026034791,
0.026970334,
-0.0055698147,
-0.02948293,
-0.002731448,
-0.0018510362,
0.008961154,
0.017989133,
0.013451754,
-0.01757482,
-0.008426558,
0.04239341,
-0.014033127,
-0.013979668,
-0.018951403,
-0.0033328678,
-0.009696223,
0.0016555749,
-0.02967004,
0.0045774723,
-0.0021768054,
0.026409008,
0.020100784,
0.0007354862,
0.03418737,
-0.002203535,
-0.012141996,
-0.0062881773,
0.017641645,
-0.03972043,
0.047659174,
-0.015650278,
0.013030761,
0.016118048,
0.015623548,
-0.020394811,
0.011086171,
-0.007083388,
-0.013805924,
-0.0033094792,
0.026622847,
-0.001699846,
-0.039239295,
-0.024377545,
-0.03405372,
-0.015677007,
0.033599317,
-0.015543358,
0.0199805,
0.03314491,
-0.011834604,
-0.002564387,
0.038464133,
0.001264652,
-0.020702204,
0.011139629,
0.029081985,
-0.026435738,
-0.015690373,
-0.03774243,
0.019205337,
-0.023802856,
-0.0017691763,
0.0035249877,
-0.0064719445,
-0.0035684237,
-0.014367249,
0.0011009322,
-0.012121948,
-0.013057491,
-0.00031511887,
-0.024564655,
-0.00037045786,
-0.02282722,
-0.004316857,
-0.024537925,
0.030151175,
0.013030761,
0.028119713,
-0.010658494,
-0.008947789,
-0.004574131,
-0.010778778,
0.028333552,
-0.009956838,
-0.01940581,
-0.017173875,
-0.015717102,
0.022533193,
0.008025612,
0.008446606,
0.015997766,
0.00021947644,
-0.012081854,
-0.04653652,
0.005011831,
0.009529161,
-0.015195872,
-0.011166359,
-0.011507164,
-0.003618542,
-0.014540993,
-0.0038390625,
-0.0019830144,
-0.013378248,
0.0014851727,
-0.010631764,
-0.0051254327,
-0.02334845,
-0.018897945,
0.019178607,
-0.032984532,
0.021370448,
0.034508128,
0.00013907831,
-0.00042851156,
0.036833618,
-0.007551159,
0.0010048721,
-0.00884087,
-0.006769313,
0.0031273826,
-0.006010856,
-0.004240009,
-0.006779337,
-0.04776609,
-0.026836684,
0.011460387,
-0.019392446,
-0.029081985,
-0.00854016,
0.008439924,
0.017200604,
0.0272109,
-0.0104580205,
-0.024230532,
0.002469162,
-0.013819288,
-0.0067459247,
0.0040328535,
-0.025887778,
-0.0027832368,
-0.0015252673,
-0.015971035,
0.040121377,
0.013779194,
-0.00067617954,
-0.016666008,
0.000503689,
-0.019472634,
-0.005907278,
-0.0084867,
-0.01606459,
-0.031380747,
0.0120350765,
0.021504097,
0.011553941,
0.007978835,
-0.00070165633,
-0.019579554,
-0.008961154,
-0.03905219,
0.017427808,
-0.022239165,
-0.048140306,
0.0070767053,
0.023989964,
0.010204088,
0.017494632,
0.008921059,
-0.012322422,
-0.019592918,
-0.03849086,
0.035096183,
0.01026423,
-0.0032693844,
-0.009489067,
0.037368212,
0.0377157,
0.0073640505,
-0.04207265,
0.03079269,
0.027117347,
0.009495749,
-0.023936504,
0.013551991,
0.015717102,
0.00831964,
0.016358616,
0.011426975,
-0.017000131,
0.02000723,
-0.0014985375,
0.028092984,
0.002961992,
-0.00090212957,
-0.00845997,
-0.014915209,
-0.0039159106,
0.017307524,
-0.014741465,
-0.032530125,
-0.0284672,
0.008439924,
0.0012362517,
0.01538298,
0.01428706,
-0.0045039654,
-0.02619517,
0.00470778,
-0.013084221,
-0.0045306953,
-0.00019901145,
0.029081985,
0.026462467,
0.011781144,
-0.00075595116,
0.004387023,
0.010444656,
-0.014273695,
0.023281626,
-0.029001797,
0.012268962,
-0.013371565,
0.041404407,
0.002200194,
-0.03982735,
-0.013699004,
-0.0040662657,
-0.0075778887,
0.013471802,
0.004918277,
-0.012803557,
0.08275536,
0.015449804,
-0.03549713,
-0.014420709,
-0.011874698,
0.026368914,
-0.014180141,
0.013498532,
-0.022720302,
-0.021717934,
0.035229832,
-0.048674904,
0.0039526643,
-0.030605583,
-0.020982865,
0.021196704,
-0.0033245145,
0.016345251,
0.011019346,
-0.003374633,
-0.005312541,
-0.01653236,
0.0016564102,
0.011066123,
-0.027798956,
-0.009248499,
0.040655974,
-0.008326322,
0.0012679932,
-0.024310721,
0.013926208,
-0.0040027825,
-0.04324876,
0.019165242,
0.015062223,
0.0025710694,
-0.0049750777,
-0.012696639,
0.0217313,
0.031567853,
-0.0071101175,
-0.011854651,
-0.0040027825,
-0.019673107,
0.0006172905,
0.00996352,
0.0023472076,
0.004356952,
-0.016866483
] |
The first Swiss human embryonic stem cell (hESC) line, CH-ES1, has shown features of a malignant cell line. It originated from the only single blastomere that survived cryopreservation of an embryo, and it more closely resembles teratocarcinoma lines than other hESC lines with respect to its abnormal karyotype and its formation of invasive tumors when injected into SCID mice. The aim of this study was to characterize the molecular basis of the oncogenicity of CH-ES1 cells, we looked for abnormal chromosomal copy number (by array Comparative Genomic Hybridization, aCGH) | [
-0.005962559,
-0.00066143466,
-0.009676995,
-0.03341986,
-0.013945073,
-0.0025064894,
-0.0122002615,
0.0077979667,
-0.025138712,
-0.0039962903,
-0.008448916,
0.008576421,
-0.0010930239,
0.008965649,
-0.0095562,
0.009542778,
0.030252352,
-0.004865341,
-0.00088750524,
0.0072275475,
-0.030010764,
0.0013950106,
0.017609177,
-0.0045532878,
0.005023045,
0.011649975,
-0.0005536422,
-0.02142092,
-0.01178419,
-0.0166294,
-0.0041137296,
0.013663218,
-0.0084958915,
-0.008999202,
-0.03476202,
0.0054659587,
0.007670461,
-0.014428251,
0.018213151,
0.0011634876,
0.03022551,
0.0067645013,
-0.0106299305,
0.006120263,
0.0034309041,
0.009334743,
-0.021018272,
-0.016535448,
-0.008469048,
0.026064804,
0.019098978,
0.02052167,
-0.013374654,
0.015408031,
-0.02775593,
0.013005559,
-0.008026134,
0.0061504617,
0.00580821,
-0.0078919185,
0.0075832205,
-0.004828431,
-0.027809616,
0.017515227,
-0.0019444586,
0.016267015,
-0.020266661,
0.009180395,
-0.0021071958,
-0.0009302867,
0.010301101,
-0.00490225,
0.00284203,
-0.006754435,
0.01120035,
-0.00626119,
-0.03113818,
0.007475848,
0.0129652945,
-0.002055187,
0.017662864,
-0.046680428,
-0.009234081,
0.0031943477,
-0.0028235754,
0.025246086,
-0.00039258267,
0.0015426485,
-0.0056203073,
0.0116969505,
0.031997163,
0.014790636,
0.00047772613,
0.0002894039,
-0.029205466,
-0.007878496,
-0.011113109,
0.019823747,
-0.0024259596,
-0.040479634,
-0.0059692697,
-0.0009864898,
-0.00938843,
-0.024279729,
-0.037043698,
0.00081788056,
0.02974233,
-0.010247414,
0.013864543,
-0.019864012,
0.0018974829,
0.023809971,
-0.014226927,
-0.0072543905,
0.03814427,
-0.0017867545,
0.035272043,
0.01581068,
0.0106299305,
-0.013784014,
0.018884232,
0.0085965535,
0.010509136,
-0.039056942,
0.036479987,
0.024346836,
-0.036936324,
0.0035097562,
-0.004976069,
-0.014777214,
0.004137217,
-0.010489004,
0.032802463,
0.005180749,
-0.017609177,
-0.011012447,
-0.016267015,
-0.0045063123,
-0.00043578353,
-0.01829368,
0.014522203,
0.03350039,
0.0068852957,
0.0070799096,
-0.0019377477,
-0.0020065336,
0.0021759816,
0.015260393,
0.0042848554,
0.01885739,
0.01893792,
-0.009650151,
0.035433102,
0.010582955,
-0.0029812795,
0.01219355,
0.01688441,
0.017984983,
-0.024776328,
-0.002763178,
-0.02775593,
0.0034460034,
0.008549578,
0.006335009,
0.014669841,
0.034144625,
0.0017548781,
0.0077308584,
0.0039325375,
-0.0070060906,
-0.01160971,
0.035379414,
-0.016763614,
0.011468782,
-0.019206353,
0.0057142586,
-0.01095876,
0.023192575,
-0.04834471,
-0.012643175,
-0.022843614,
0.018226573,
0.037822153,
-0.0044425596,
-0.02939337,
0.009401851,
0.0072007044,
-0.007569799,
0.0106299305,
-0.015636198,
-0.009073022,
-0.008737481,
0.02116591,
0.0007860042,
-0.6450972,
-0.048398394,
-0.00061403954,
-0.0038889172,
0.017126,
0.04442559,
0.026212443,
-0.013710194,
-0.01648176,
-0.0058014994,
-0.033097737,
0.0077241478,
0.0055968193,
-0.019716375,
-0.026977476,
-0.040076986,
-0.007918761,
-0.019501628,
0.027339859,
0.0071268855,
-0.0012356287,
0.01622675,
-0.009683706,
0.010945339,
0.0022900656,
0.009133419,
0.012623043,
-0.006992669,
-0.015085911,
0.024360258,
-0.0033839284,
0.026454031,
-0.01507249,
-0.011166796,
0.04297606,
-0.0032581005,
0.0023521406,
0.003566798,
0.018146044,
0.039244846,
-0.0010225604,
0.0041137296,
0.0051773936,
0.003573509,
-0.014777214,
0.021380655,
-0.0071067526,
-0.0020568648,
-0.012341188,
0.0057109036,
0.010401763,
-0.00013767656,
-0.008932094,
-0.00012498892,
0.00043410584,
-0.011649975,
0.034815706,
-0.013985338,
0.01449536,
0.013555846,
-0.0028772617,
0.028507542,
-0.017971562,
-0.0149382735,
0.00015571187,
0.030279197,
-0.0018823835,
-0.007073199,
0.0018756727,
-0.014656419,
0.023595225,
0.03688264,
-0.030762374,
0.008462338,
-0.008556289,
0.042412348,
-0.011549313,
-0.021541715,
0.0024595135,
0.00059516536,
0.0054827356,
-0.0071671503,
-0.016401231,
0.024252884,
0.0075563774,
-0.014642998,
-0.023246262,
0.01829368,
-0.028937032,
0.007757702,
0.006831609,
0.0058988063,
0.008878408,
-0.034708332,
-0.003347019,
0.00490225,
-0.016387809,
0.016119378,
-0.0028202198,
-0.037768465,
-0.013945073,
-0.0032413236,
0.0014679907,
0.000090229005,
0.007918761,
0.009992403,
-0.016253592,
-0.0062477686,
0.047083076,
-0.04447928,
-0.012703572,
-0.0040667537,
-0.005576687,
-0.008791167,
0.013522292,
-0.021769883,
-0.007710726,
0.03132608,
0.009099864,
-0.034359373,
0.016857566,
-0.014965117,
-0.012186839,
-0.010086355,
0.0119989365,
-0.0012398231,
0.0020769972,
-0.016495183,
-0.003878851,
-0.027863303,
0.02356838,
-0.015743572,
0.015931474,
-0.043190803,
0.032909837,
-0.0054827356,
0.00096467964,
0.00081200857,
0.009623309,
0.0031926702,
-0.029554429,
-0.006160528,
0.013052534,
-0.006925561,
-0.016548868,
0.0004336864,
0.0014629576,
-0.0152469715,
0.008079821,
-0.009616598,
0.009757524,
0.0031222065,
-0.00621757,
0.02134039,
0.030386569,
-0.017179687,
0.0017968207,
-0.03237297,
0.010656774,
-0.021326968,
-0.018186308,
0.017582335,
-0.011737215,
0.02142092,
0.006965826,
0.0034862682,
-0.001771655,
0.0012549224,
-0.020132445,
-0.024521317,
-0.012891475,
-0.003714436,
-0.013200172,
0.031003963,
-0.008388518,
0.0021709485,
-0.016199907,
-0.01927346,
-0.008254302,
-0.013555846,
-0.008999202,
-0.023273105,
0.0037848996,
-0.0059994683,
0.031809263,
0.027863303,
0.0117976125,
0.0063115214,
0.014669841,
0.02661509,
-0.006351786,
0.0042211027,
-0.015689885,
0.029554429,
0.00675779,
-0.0149382735,
-0.00094370835,
0.02759487,
0.016347544,
0.041741267,
0.03205085,
0.006828254,
0.015032225,
0.00025626924,
0.020226395,
-0.03978171,
-0.011408385,
-0.009542778,
-0.0015275492,
0.009583044,
0.0016466662,
-0.007871786,
-0.007388607,
0.0022967763,
0.0070128012,
-0.026480874,
-0.011361409,
-0.026668778,
0.0011701983,
-0.0095562,
-0.015327501,
0.0007365119,
0.011354699,
0.0022615446,
-0.006868519,
0.017649442,
0.024454208,
0.020467985,
0.015421452,
0.007026223,
0.014240349,
0.022333592,
0.013810857,
-0.0017246794,
0.023420744,
0.022803348,
0.025313193,
-0.0008057172,
0.024575004,
-0.0073483423,
-0.013428341,
0.019407677,
0.010267546,
0.012005648,
-0.001194525,
-0.019649265,
0.022857035,
0.019286882,
-0.021300126,
0.02725933,
-0.01309951,
0.0038520077,
-0.0037748334,
0.016454918,
-0.00071763777,
-0.015434874,
-0.0048116543,
0.008563,
0.018226573,
0.0031188512,
0.006439027,
-0.027326437,
0.0076301964,
0.0025165556,
0.002100485,
0.001143355,
0.0052042366,
0.0046002637,
-0.030816061,
-0.017434698,
-0.015515404,
0.0073282095,
0.00391576,
-0.022534916,
0.0031020741,
0.013240437,
0.024736064,
-0.0003011478,
0.022964409,
0.009609886,
-0.020749839,
-0.013233727,
0.016347544,
0.023205997,
-0.00062200864,
-0.008301278,
-0.021729618,
0.004835142,
-0.00009379412,
0.007844943,
0.00031016546,
0.004241235,
-0.0017171297,
-0.011670107,
-0.02356838,
-0.0074221613,
-0.01177748,
-0.029044406,
0.029259153,
0.0033168201,
0.0098045,
-0.018065514,
-0.009354875,
-0.00049492257,
0.02634666,
0.01589121,
0.001137483,
-0.017112577,
-0.0051404843,
-0.025930589,
-0.010589666,
-0.032721933,
-0.00938843,
0.010804412,
-0.005395495,
-0.003147372,
0.01350887,
0.014052446,
0.03360776,
-0.0066504176,
-0.009596465,
-0.038359016,
-0.01664282,
-0.021850413,
0.033393014,
0.049713716,
-0.0140256025,
0.00022732886,
0.042439193,
0.0038016764,
-0.003986224,
-0.035298884,
0.009495803,
-0.011723793,
-0.0012498893,
-0.0119989365,
0.0014168208,
0.005804855,
0.0014226927,
0.022615446,
-0.0045901975,
-0.0012750548,
0.0062410575,
-0.0047076363,
-0.0064591593,
0.0043217647,
0.018991606,
0.04923054,
0.014978538,
-0.0002537527,
-0.004784811,
-0.000020958189,
-0.008583132,
-0.0006094259,
-0.031487145,
0.012321056,
0.0014059157,
-0.0014252092,
-0.0012809268,
-0.015716728,
0.0030550985,
0.0057041924,
0.0010267546,
-0.014092711,
0.031997163,
0.000033580287,
-0.0009562911,
-0.009039467,
-0.007858364,
0.004949226,
0.006720881,
0.0023504628,
-0.007502691,
-0.031889793,
0.037848994,
-0.031997163,
-0.013455183,
-0.0019612357,
0.00029192044,
0.016334124,
-0.02586348,
-0.005221014,
-0.0067141703,
0.010059511,
-0.009871609,
-0.0352452,
0.00889854,
0.01927346,
-0.014629576,
-0.009354875,
-0.0023202642,
-0.0029242376,
-0.01622675,
-0.011670107,
0.027380124,
-0.0228973,
-0.044157162,
0.0003766445,
0.009509224,
0.012730416,
0.0012834433,
-0.016790459,
-0.0027598226,
0.034305684,
0.01606569,
-0.015005382,
0.0013748782,
-0.02281677,
-0.0069591147,
0.0016064013,
0.019595578,
-0.018870812,
-0.035969965,
0.01012662,
0.015233549,
-0.016924676,
-0.0049290936,
-0.015703306,
-0.024521317,
0.0085965535,
0.010012535,
0.0065329783,
-0.0149382735,
0.006415539,
-0.008945516,
-0.03870798,
-0.014763792,
0.0016055624,
0.0012792491,
-0.003061809,
-0.0065765986,
0.005221014,
-0.004036555,
-0.0012834433,
-0.0006610153,
-0.02544741,
0.00568406,
-0.0052377908,
0.006063221,
-0.00469757,
-0.0015602644,
0.014790636,
0.001415143,
-0.0090596,
0.009455538,
-0.0102205705,
0.031970322,
-0.0061001307,
-0.021474607,
0.0015862689,
0.012831078,
-0.0048116543,
-0.030869748,
-0.0061806603,
-0.016374389,
0.023729442,
-0.016911253,
-0.011193639,
-0.014817479,
-0.019716375,
-0.0031322727,
0.020387456,
0.015287236,
-0.015636198,
0.0013975272,
0.0112339035,
-0.014092711,
-0.006563177,
0.0058216318,
-0.03696317,
-0.01350887,
0.025621891,
0.011623131,
-0.009281057,
-0.00621757,
0.01614622,
-0.016911253,
-0.021461185,
0.01449536,
-0.030171823,
0.0019864012,
0.0010905074,
0.04705623,
0.027890146,
0.027044583,
-0.017448118,
0.015944896,
0.037902683,
0.015743572,
0.0119989365,
-0.01614622,
0.022145689,
-0.010764147,
0.030574473,
-0.0021424277,
-0.010811122,
0.013488738,
-0.008965649,
0.009589754,
0.03559416,
0.0119989365,
-0.015756993,
0.021528294,
-0.040533323,
-0.05245173,
-0.0025735975,
0.0010158495,
0.009723971,
-0.0352452,
-0.004596908,
0.027232487,
-0.0042143916,
-0.0073013664,
-0.010589666,
0.016320702,
-0.004761323,
0.016280437,
-0.018468162,
0.010737304,
0.004499601,
-0.014267192,
-0.0017347456,
-0.0028168645,
0.013455183,
0.0011601321,
0.009730682,
0.026896946,
-0.031487145,
0.020776682,
0.02100485,
-0.019998228,
0.017649442,
-0.01688441,
-0.023662332,
-0.014589312,
-0.026467454,
0.0035131115,
-0.03360776,
0.015837522,
0.0036506832,
-0.016428074,
0.011113109,
-0.014012181,
-0.0012943484,
-0.006220925,
-0.0034359372,
0.031943478,
-0.011757348,
0.024440788,
0.018320525,
-0.015944896,
-0.028185422,
-0.0076167746,
0.010032668,
0.0112339035,
0.022615446,
0.010515846,
-0.009133419,
-0.014508781,
0.0011399996,
0.020145865,
-0.02355496,
-0.034976766,
0.0039996454,
-0.0017020304,
-0.0004626268,
-0.01680388,
-0.022494651,
-0.0047781,
0.010341366,
-0.014092711,
0.009723971,
0.012327767,
-0.021071957,
-0.0054458263,
0.027192222,
-0.018401055,
0.016387809,
0.009415273,
0.00029401758,
-0.016508603,
-0.0324535,
-0.021971207,
0.026292972,
0.0033436634,
0.046411995,
-0.022051737,
0.0014772181,
0.019206353,
-0.0074087395,
-0.016454918,
-0.007455715,
0.007965737,
0.036936324,
-0.007945605,
0.006475936,
0.0068852957,
-0.00064172165,
0.012589488,
0.0008426267,
-0.01111982,
-0.000027472397,
-0.028158579,
-0.021367233,
0.03468149,
0.012992137,
0.0023336858,
-0.019098978,
-0.019582158,
-0.014575889,
-0.0243871,
-0.0400233,
-0.0055062235,
-0.03336617,
0.004479469,
0.00076629117,
0.032507185,
0.03403725,
0.015756993,
0.0069591147,
0.0010393375,
0.03929853,
0.0039459593,
0.016387809,
0.011025868,
0.014213505,
-0.03387619,
0.007965737,
0.004801588,
-0.005865252,
-0.027474076,
-0.018642643,
-0.02421262,
-0.031889793,
-0.001890772,
0.022279905,
0.010502425,
-0.006878585,
0.00897907,
0.015783837,
0.03014498,
0.005905517,
-0.030681845,
0.003805032,
-0.029285995,
-0.015166441,
-0.0021239729,
-0.014844323,
-0.01399876,
-0.006687327,
-0.004341897,
-0.016186485,
-0.018226573,
-0.00058803515,
0.0010921851,
-0.0029410145,
0.009354875,
0.0071872827,
-0.013126354,
-0.013059245,
-0.007791256,
0.008274434,
0.011502337,
-0.012844499,
-0.032346126,
-0.0065094903,
0.009515936,
0.01836079,
-0.011314434,
0.0079925805,
-0.0047512567,
-0.0053854287,
-0.04045279,
0.0075563774,
-0.001710419,
0.032480344,
0.03368829,
-0.0020652532,
-0.031755574,
0.0024108603,
-0.061471064,
-0.020561937,
-0.010603087,
0.02709827,
0.011092977,
0.035433102,
-0.00097894,
0.0003657394,
0.0010041057,
-0.006563177,
-0.002152494,
-0.017260216,
0.021031693,
-0.017407853,
0.011629842,
0.023702597,
-0.03261456,
-0.0078046774,
0.022212796,
0.012206972,
0.003788255,
0.00588874,
-0.012696861,
0.04646568,
0.026896946,
0.010851388,
0.011160085,
0.029957077,
0.02661509,
-0.018843967,
-0.0028386747,
0.011160085,
0.0034225155,
0.0020937743,
-0.0052042366,
-0.012468694,
-0.008214037,
-0.00036322285,
-0.014777214,
-0.0044224267,
0.0079925805,
0.010099776,
0.00032903964,
0.0043284753,
0.0061974376,
0.017729973,
0.020159287,
0.002994701,
-0.009945427,
-0.0014361143,
-0.0137236165,
0.0007117658,
-0.008771035,
-0.002982957,
0.003061809,
-0.008180483,
-0.011676817,
-0.015703306,
-0.005791433,
0.00024305732,
0.008858276,
-0.013186751,
0.029608116,
-0.0191124,
-0.028319638,
-0.01670993,
0.008012713,
-0.018521849,
-0.005952493,
-0.0024041494,
-0.001347196,
-0.046653584,
0.02660167,
-0.014052446,
-0.004093597,
-0.021608824,
0.009415273,
-0.0042479457,
-0.007844943,
0.011958672,
0.19702952,
-0.0011005736,
-0.0051203514,
0.01919293,
0.00095545227,
-0.024038138,
0.004224458,
0.008106664,
-0.0071872827,
0.011710372,
-0.00061907264,
0.007395318,
-0.0058350535,
-0.0040298444,
0.038332175,
-0.015032225,
-0.015515404,
-0.0048384974,
-0.010643352,
-0.031084495,
0.0026071516,
-0.021971207,
0.043351863,
-0.012649885,
-0.006831609,
-0.017072313,
-0.040909126,
-0.004892184,
0.035459947,
-0.0011290946,
-0.031675044,
0.0012574389,
0.018199729,
-0.0143343005,
-0.0059088725,
-0.017676286,
0.00568406,
0.009898452,
-0.0052143033,
-0.017743394,
-0.018964762,
0.003187637,
0.021877255,
0.011267458,
-0.002031699,
0.019783482,
-0.0054558925,
-0.0073349206,
0.018803703,
-0.012649885,
-0.045177206,
0.010905074,
0.0070799096,
0.032265596,
0.019233195,
-0.0050700204,
0.038010053,
-0.002451125,
-0.0040331995,
0.016186485,
-0.017823923,
0.011522469,
-0.011884853,
0.015743572,
-0.0125559345,
0.036399458,
-0.013193462,
-0.0020702863,
-0.0007281234,
0.0044761132,
0.0050700204,
-0.012374742,
-0.032990366,
-0.00037035308,
-0.00095545227,
-0.027004318,
0.046492524,
-0.00032757164,
0.006365208,
0.029473899,
0.0044022943,
0.0025266218,
-0.028937032,
-0.003142339,
-0.004570065,
-0.049123164,
0.047566254,
0.02725933,
-0.017971562,
-0.008274434,
0.0093079,
0.005818276,
0.005083442,
0.0036674603,
0.04050648,
-0.005499513,
0.018065514,
0.016656242,
0.006549755,
-0.0111869285,
-0.029608116,
0.04348608,
0.0111869285,
0.0010007502,
-0.018065514,
0.0067980555,
0.0005955848,
-0.0036003522,
-0.0032698445,
0.0043754512,
-0.0002946467,
-0.022857035,
-0.0036204846,
-0.018065514,
-0.016334124,
0.021783305,
-0.0061504617,
-0.03296352,
0.04713676,
-0.02017271,
0.0059021614,
-0.015931474,
-0.0018488294,
0.042304978,
-0.008999202,
-0.0074490043,
-0.019890854,
-0.0017548781,
-0.015783837,
-0.014616154,
-0.012535802,
-0.0029577916,
0.019219773,
0.019058714,
0.010368208,
-0.0066906824,
-0.006747724,
0.010146752,
-0.028400168,
0.0051606167,
-0.01869633,
-0.010777568,
-0.0024813237,
0.0033268863,
-0.0027027805,
-0.024279729,
0.019313725,
0.008046267,
-0.023044938,
-0.035110984,
-0.0140256025,
-0.024575004,
-0.0026054739,
-0.018602379,
0.025433987,
-0.031084495,
-0.0127572585,
-0.04356661,
-0.008415362,
0.013408208,
-0.023595225,
0.035298884,
0.0016349222,
-0.007932183,
0.002927593,
-0.020790104,
-0.17018627,
0.0047881664,
0.010435317,
-0.018884232,
0.009274346,
0.0063215876,
-0.004070109,
-0.018387632,
0.0004315893,
0.0052042366,
0.047458883,
0.0073684747,
-0.043539766,
-0.029098094,
0.020978007,
0.02446763,
-0.014253771,
0.026400344,
0.025662156,
0.0017196463,
0.039942767,
-0.02619902,
0.023098625,
0.008509313,
-0.0022716108,
-0.000113140144,
-0.003103752,
-0.0063282982,
-0.007650329,
-0.0243871,
-0.016669665,
0.007240969,
0.025541361,
0.0103749195,
0.0040432657,
-0.0034493587,
-0.0031003964,
-0.011019158,
-0.002439381,
0.015743572,
0.038949568,
0.012488826,
-0.0068584527,
-0.011059423,
0.0061638835,
0.032990366,
-0.002524944,
-0.03336617,
0.044855084,
-0.016736772,
0.026990896,
-0.0065933755,
0.013018981,
0.0064457376,
0.017488383,
0.01787761,
0.026064804,
0.006828254,
0.011240615,
0.003533244,
-0.0017146132,
-0.021810148,
0.02116591,
-0.017716551,
0.0012012358,
-0.035728376,
0.0058216318,
-0.01111982,
-0.028963877,
0.017273637,
-0.018897654,
0.004308343,
0.007462426,
-0.016656242,
0.041392304,
-0.008710638,
0.013810857,
0.017367588,
-0.0005679027,
-0.016495183,
-0.023393901,
0.015542247,
-0.020870633,
-0.011529179,
0.00807311,
0.0044459146,
-0.0023034872,
0.013743749,
0.00078348763,
-0.001143355,
-0.0077979667,
-0.016454918,
0.002848741,
-0.013455183,
0.0034493587,
0.014106133,
-0.014213505,
-0.017300481,
-0.008965649,
0.0067510796,
0.024360258,
-0.0030215443,
-0.024011295,
0.015824102,
0.020655887,
-0.0050364663,
-0.0238905,
0.022212796,
0.04568723,
-0.020347191,
-0.011381541,
0.015824102,
0.020333769,
0.03137977,
0.015112755,
0.033903036,
-0.010643352,
-0.001783399,
-0.010831255,
-0.04455981,
0.050250582,
-0.027205642,
-0.0008245914,
0.032319285,
-0.0071268855,
-0.015300658,
-0.121868394,
-0.0020082113,
-0.0017079023,
0.007073199,
-0.020575358,
0.025178976,
0.0063048103,
0.024843436,
-0.019380832,
0.03468149,
-0.005100219,
-0.036399458,
0.014012181,
-0.004217747,
0.029339682,
0.010395052,
0.015515404,
0.0027715664,
-0.023031516,
0.04085544,
0.013918229,
-0.00465395,
-0.014602733,
-0.035808906,
0.020494828,
0.029447054,
-0.029715488,
0.014763792,
0.024239464,
0.02974233,
0.01350887,
-0.011676817,
0.00294437,
0.01696494,
-0.022373857,
-0.01491143,
-0.028373325,
-0.027863303,
0.018172886,
-0.026225865,
-0.008354965,
0.02092432,
-0.013280703,
-0.011347988,
0.0020887412,
-0.0067410134,
-0.017676286,
-0.0008480792,
0.014428251,
-0.020347191,
-0.017488383,
-0.016320702,
0.010032668,
0.014320878,
0.016213328,
-0.0140256025,
0.0137705915,
0.01656229,
-0.016790459,
-0.016844144,
0.0007360925,
-0.021380655,
-0.00782481,
-0.0072275475,
-0.00023718536,
0.0024058272,
-0.030171823,
-0.016575713,
0.011790901,
-0.014602733,
-0.014119554,
0.016575713,
-0.024937388,
-0.0027229132,
-0.02725933,
-0.0092072375,
-0.0016030459,
-0.006029667,
0.011683528,
0.006318232,
-0.017703129,
-0.018052092,
0.018830545,
-0.014522203,
0.021058537,
0.0017884321,
0.01688441,
-0.023004673,
0.008167062,
-0.016374389,
0.010911785,
0.02570242,
-0.0332588,
-0.023125468,
-0.0038587186,
0.01672335,
0.011656685,
0.0005599336,
0.020897478,
0.02150145,
-0.008623397,
-0.025541361,
-0.062007926,
0.028561227,
-0.012737126,
-0.011381541,
-0.0043720957,
-0.00022061804,
0.012663308,
-0.005395495,
0.015622777,
0.020051915,
0.022508072,
0.0062410575,
-0.011710372,
0.009985692,
-0.025474252,
-0.014428251,
0.0077308584,
0.015824102,
0.0031675044,
0.020776682,
-0.017998405,
-0.02899072,
-0.00095377455,
0.011354699,
0.005278056,
-0.003878851,
-0.0052176584,
0.03403725,
0.0033201757,
-0.027487498,
0.014562468,
-0.031594515,
-0.008710638,
-0.0016793814,
-0.007985869,
-0.0025954077,
0.0048485636,
0.020481406,
0.019877434,
0.021326968,
-0.021729618,
-0.019058714,
0.016280437,
0.018629221,
-0.009676995,
0.002712847,
-0.020830369,
0.027970675,
0.004865341,
-0.0013111255,
0.026856681,
0.0071805716,
0.00938843,
-0.028641757,
-0.0038520077,
-0.022937564,
0.00076629117,
0.00354331,
-0.011737215,
-0.008214037,
0.01837421,
0.019179508,
0.028856503,
0.0032916546,
-0.027380124,
-0.0025668866,
-0.021367233,
-0.013408208,
-0.00072896224,
-0.032721933,
-0.019568736,
0.0047143474,
0.01573015,
0.02058878,
0.002378984,
-0.0036204846,
-0.014374565,
0.019998228,
-0.009314611,
-0.013018981,
0.013643086,
0.019877434,
-0.026749307,
-0.0101735955,
0.017528648,
0.004704281,
-0.010737304,
0.020320347,
0.010314522,
0.005865252,
-0.016522026,
0.016079113,
0.006187371,
-0.003154083,
-0.00774428,
0.021944365,
-0.00757651,
0.014347722,
0.01705889,
0.021233018,
-0.0015049002,
0.018078934,
0.014213505,
-0.018186308,
-0.021353813,
0.021380655,
-0.015958317,
-0.021259861,
-0.0149382735,
-0.014320878,
0.015783837,
0.01226737,
0.00741545,
0.015112755,
-0.022051737,
0.007677172,
0.014750371,
0.0010888297,
-0.0018706396,
0.030520786,
0.0062309913,
0.013535714,
0.022092002,
0.007650329,
-0.0044257822,
0.015850944,
0.027272752,
-0.021890678,
0.018642643,
-0.0062041483,
0.02676273,
-0.0067980555,
-0.006965826,
-0.022575181,
-0.01622675,
-0.017555492,
0.000515055,
-0.0069322716,
-0.030252352,
0.07704015,
0.011139953,
-0.019085556,
0.012508959,
-0.012327767,
0.020467985,
0.028292796,
0.0070128012,
-0.007563088,
-0.03476202,
0.02191752,
-0.024830015,
0.0091602625,
-0.030386569,
-0.017219951,
0.015770415,
-0.0045432216,
-0.0020920965,
-0.019729795,
-0.024252884,
0.0040667537,
0.00078055164,
0.022105424,
0.016911253,
0.00028059594,
0.011804323,
0.02619902,
-0.01845474,
0.00038859813,
0.008247592,
0.0039224713,
-0.0022498006,
-0.048129965,
-0.00848918,
-0.0075429557,
-0.002446092,
0.003707725,
-0.03376882,
0.016414654,
0.020333769,
-0.012133153,
0.024695799,
-0.0037110806,
-0.009455538,
-0.0064356714,
-0.01350887,
-0.0065296227,
-0.013018981,
-0.007173861
] |
BACKGROUND Breast cancer is the most common malignancy in women. There is increasing evidence suggesting that ORAI1, components of store-operated calcium channel, play a pivotal role in breast cancer progression and metastasis. METHODS A total of 384 female patients with breast cancer were included in this study. We selected five representative tagging ORAI1 SNPs from HapMap database with minimum allele frequency (MAF) >10%. Genotyping was performed using TaqMan allelic discrimination assay. Chi-square (χ²) test was used to analyze statistical differences among control and patient groups in genotype and allelic frequencies. RESULTS Two of the OR | [
-0.020331733,
-0.011658662,
-0.009740319,
-0.05330832,
-0.019548185,
0.003745497,
-0.028667068,
-0.015833084,
-0.02315521,
-0.020129092,
0.0006117251,
-0.0045661964,
0.016738217,
0.00056275335,
-0.011429001,
0.0036306665,
0.036691684,
0.0038907237,
-0.0062447465,
-0.002225683,
-0.041717205,
0.018832183,
-0.00063156715,
-0.004366932,
0.011672171,
0.010658962,
0.014833384,
-0.0462834,
0.0027069575,
-0.02688382,
0.014914441,
0.020061543,
-0.02016962,
0.013955269,
0.0064879167,
0.0164275,
0.011523567,
0.0010039215,
0.014738818,
-0.02265536,
0.003379053,
0.0046641403,
0.005042405,
-0.0017325879,
-0.02015611,
-0.0124557195,
0.00091357704,
-0.018183729,
-0.016832784,
0.0051133297,
-0.004626989,
0.01618433,
-0.008673072,
-0.009571451,
-0.009497148,
-0.010321225,
0.01691384,
0.011098019,
0.0073558996,
-0.024762835,
-0.00081056746,
0.0102266595,
-0.046958875,
0.018980788,
-0.0013534788,
0.015752027,
-0.009429601,
0.016765237,
0.016738217,
0.017197538,
0.023628041,
0.027248574,
-0.036016215,
-0.00035757845,
0.013408137,
-0.026721707,
-0.013495948,
-0.009530922,
-0.0048262537,
0.009260733,
0.023952268,
-0.016765237,
0.004525668,
0.014482138,
0.012948815,
0.014320024,
-0.024924949,
0.015414291,
0.0010984878,
-0.0013940071,
0.02212849,
-0.013293306,
0.0037421198,
-0.0020196638,
-0.016603123,
-0.0015012384,
-0.012658361,
0.029018315,
0.0025938158,
-0.019115882,
0.0076801265,
0.008119184,
-0.006832408,
-0.0053565,
-0.020264186,
0.008531222,
-0.030693486,
0.0032676,
0.024492646,
0.0020990318,
-0.011618134,
0.032071453,
-0.0071802763,
-0.0019436731,
0.020791056,
-0.005626689,
0.015481838,
-0.009929451,
-0.024519665,
-0.0010799122,
0.033260282,
0.009152657,
0.00037214332,
0.012226059,
0.015738517,
-0.005731387,
-0.01318523,
-0.012563795,
-0.0024131269,
-0.02088562,
0.027221557,
-0.0057921796,
0.030693486,
0.014900931,
-0.0111182835,
-0.0037927802,
-0.025546383,
-0.0039076107,
-0.013137947,
-0.03061243,
0.00032781542,
0.017616332,
-0.012482738,
-0.015414291,
-0.029099371,
0.02661363,
0.020277696,
0.008382618,
0.0072208047,
0.0014775969,
-0.0015552762,
-0.023236267,
-0.0042858752,
-0.01394176,
0.009666016,
0.0039548934,
-0.0046134796,
0.020791056,
-0.036961876,
-0.03858301,
0.013583759,
0.0124557195,
0.0020230412,
0.021317923,
0.017737918,
0.021547584,
0.023898229,
-0.013414891,
-0.011928851,
-0.02465476,
-0.011969379,
0.02065596,
-0.028856201,
0.014779346,
-0.0032642225,
0.004012309,
-0.005525368,
-0.0057482743,
-0.027775444,
-0.0012969079,
-0.00025119146,
0.0010022329,
0.03558391,
-0.027748425,
-0.012286851,
0.01145602,
-0.00052391365,
-0.011895077,
-0.0069100875,
-0.041690186,
0.002284787,
0.022223057,
-0.000561909,
0.0012217616,
-0.6354849,
-0.014265987,
-0.009490394,
-0.008274542,
0.019858902,
0.027045934,
0.023519965,
-0.0068459176,
0.008234014,
0.013779647,
-0.010746773,
0.021453017,
-0.0064237467,
-0.012692135,
-0.014792856,
-0.034773342,
0.014009307,
-0.009024317,
0.013131193,
0.0017748049,
-0.028477935,
0.008092165,
-0.0026157687,
0.019156411,
0.004988367,
0.023087662,
0.0008038127,
-0.016792255,
0.0012665116,
0.03431402,
-0.018548485,
0.02836986,
0.015468328,
0.018561995,
0.044635247,
-0.015373763,
-0.0033267038,
0.04058241,
0.027721407,
0.034178928,
-0.015049536,
0.009517413,
0.021831283,
-0.02289853,
-0.03412489,
0.02018313,
0.0044918945,
0.01717052,
0.004968103,
-0.018494448,
0.00870009,
0.0045121587,
-0.049174424,
-0.02116932,
-0.00012369597,
-0.0109899435,
0.03182828,
-0.020237166,
-0.002374287,
0.017967578,
-0.006116407,
0.008152957,
-0.002272966,
-0.01669769,
-0.005630066,
-0.0007979023,
0.0014733751,
0.022574304,
0.0037151007,
0.0018339088,
0.029396579,
0.033719607,
-0.020021016,
-0.009031072,
0.040150106,
0.043500453,
0.006153558,
0.024087362,
-0.008483939,
0.013820175,
0.021723207,
0.011354699,
-0.027181027,
0.010051036,
0.02591114,
0.014036326,
-0.010111828,
0.012124738,
0.014279496,
0.012084209,
0.013664816,
-0.0071059745,
0.012003153,
-0.030963676,
0.0061299163,
0.003054826,
-0.009416091,
0.013171721,
-0.006879691,
-0.03112579,
-0.028667068,
-0.0037826481,
-0.010733264,
0.00018934348,
0.023479437,
0.008531222,
-0.018318824,
0.0001168357,
0.012550286,
-0.036286402,
-0.005653708,
-0.000292142,
0.0020585035,
-0.012381418,
-0.0014303138,
-0.013381117,
0.0135432305,
0.022749927,
0.0065216906,
-0.015400781,
0.02562744,
0.022101471,
-0.00014775968,
-0.021223357,
0.019386072,
0.015779046,
-0.0006851828,
-0.0035361005,
0.0064845397,
-0.0036644402,
0.0061603123,
-0.02688382,
-0.0011668793,
-0.02660012,
0.013820175,
0.0054004057,
0.009733564,
-0.0049714805,
0.017589314,
-0.016495047,
-0.019048335,
-0.012779946,
0.02238517,
-0.0049377065,
-0.033260282,
-0.011361454,
-0.034773342,
0.0072815972,
-0.011732964,
-0.0049005556,
0.005589538,
-0.007950315,
0.00045974372,
0.018035125,
0.0040933657,
-0.013306815,
0.006221105,
0.009787601,
0.002544844,
0.0027069575,
0.00119812,
0.014995498,
-0.014846894,
-0.018764636,
0.005616557,
-0.023722608,
-0.0007518857,
0.014482138,
-0.009287752,
-0.039636746,
0.0076531074,
-0.004201441,
-0.015454819,
-0.0017308992,
-0.011780247,
0.0077274097,
-0.015981687,
-0.02168268,
-0.006859427,
-0.015535876,
0.009253978,
-0.023276795,
-0.0130704,
-0.0077949567,
0.031423,
0.02836986,
0.035935156,
0.0106116785,
0.0004411682,
0.024127891,
-0.024317022,
0.03309817,
-0.00012422368,
0.021277396,
0.015887123,
-0.027748425,
0.0136040235,
0.009618734,
-0.0065520867,
0.013745872,
0.018278295,
0.023722608,
0.014954969,
0.007767938,
0.034665268,
0.0007763716,
0.0029568824,
0.0031054865,
0.04531072,
-0.007409937,
0.014157911,
0.016522067,
0.010908887,
0.0001247514,
-0.014509157,
0.015860103,
-0.0041980636,
0.0106116785,
0.018156711,
0.0024570324,
-0.02216902,
0.012489493,
0.014265987,
0.0036644402,
-0.015481838,
-0.00509982,
0.0042521018,
0.014603723,
0.018534975,
0.003580006,
-0.015225158,
0.019129392,
-0.0026968254,
0.0011432378,
0.011847794,
-0.013644552,
0.024033325,
0.005950916,
0.010591415,
0.0033283925,
0.00069827004,
0.02065596,
0.01594116,
0.01668418,
0.0068661817,
-0.013664816,
0.019723808,
0.0025364007,
-0.00002047527,
0.018116182,
0.0038501953,
0.004012309,
-0.022506757,
0.012381418,
0.011591114,
-0.0054274243,
0.01567097,
0.030099072,
0.017143501,
0.005498349,
0.03434104,
0.009672771,
-0.004282498,
-0.012367908,
-0.025303213,
0.011955869,
0.038447917,
0.011212849,
-0.0011043982,
-0.012003153,
-0.008092165,
0.004488517,
0.019480638,
-0.030207146,
0.0024502778,
0.012043681,
-0.00047283102,
0.02591114,
0.0033385246,
0.021088263,
-0.033206247,
-0.053443413,
0.024843892,
0.01768388,
-0.020615432,
-0.0043162717,
-0.0099699795,
0.023479437,
-0.034665268,
0.007740919,
0.01592765,
0.017359653,
-0.006433879,
0.0005196919,
-0.022587813,
0.013293306,
0.021223357,
0.00048211875,
0.0011516812,
0.011368209,
0.008801412,
-0.015643952,
0.014846894,
-0.012388173,
0.047202043,
-0.008727109,
-0.021101773,
-0.017900031,
-0.00572801,
-0.029666768,
0.007896278,
-0.03277394,
0.0061940863,
-0.0070114085,
0.01044281,
-0.004309517,
0.013468929,
-0.007950315,
0.029720806,
0.0008282986,
0.004235215,
-0.02641099,
0.012293606,
-0.0007894589,
0.02161513,
0.011982889,
-0.009355299,
0.026735216,
-0.015063045,
0.0037286102,
-0.010645452,
0.0033773642,
-0.004819499,
0.00603535,
-0.02143951,
0.01095617,
0.026964877,
0.014279496,
0.022006907,
0.028450917,
0.010537377,
-0.016711198,
0.0023725985,
-0.0010360065,
-0.0060860105,
-0.007416692,
0.026046233,
0.024911439,
0.04155509,
-0.0103549985,
0.018291805,
0.02936956,
0.01572501,
-0.016994897,
0.0005015386,
0.01045632,
-0.006126539,
0.011854549,
0.001527413,
-0.0050187632,
0.0025803063,
0.0115640955,
-0.024100872,
-0.0014168044,
0.010861604,
0.008801412,
0.0048059896,
0.013320325,
0.01592765,
-0.015549385,
0.030315222,
-0.0034955721,
0.017332634,
-0.015238668,
0.008409637,
0.0024435231,
-0.010024018,
-0.022601321,
0.01792705,
0.036853798,
-0.009875413,
-0.00834209,
0.010294206,
-0.02612729,
-0.018305315,
-0.006498049,
0.012394927,
-0.014549686,
-0.0018322201,
-0.025694987,
-0.01744071,
-0.013252778,
-0.009855149,
-0.010186131,
0.009875413,
-0.030990696,
-0.03063945,
0.00027187783,
0.017710898,
0.01621135,
0.008389373,
-0.004502027,
0.0065689734,
0.054875415,
-0.012192286,
0.0009042893,
-0.018710598,
-0.03336836,
-0.02115581,
0.012509758,
-0.006210973,
-0.014171421,
-0.014819874,
0.012246323,
0.0019014562,
-0.008625789,
0.031531073,
0.002990656,
0.0007670839,
0.0472831,
0.028937258,
0.01169919,
-0.014536176,
0.0057888026,
0.0054949718,
-0.009112129,
-0.032584812,
-0.023776645,
-0.029018315,
-0.0014294694,
0.01368508,
-0.0002809545,
-0.0032253829,
-0.004978235,
-0.013347344,
-0.008544732,
-0.0008384307,
-0.012833985,
0.009551186,
0.01740018,
0.0043770643,
0.019156411,
-0.0056233117,
0.00051082636,
0.019966979,
0.00029467503,
0.03134194,
-0.025762536,
-0.018480938,
0.016022217,
-0.0201426,
-0.0077882023,
-0.0105441315,
-0.017900031,
0.033260282,
0.029531674,
-0.011172321,
-0.048309818,
-0.006369709,
-0.006937106,
-0.028721105,
-0.0063460674,
-0.006369709,
-0.011618134,
-0.032855,
0.022439208,
0.012340889,
-0.029990995,
0.0060218405,
-0.031477034,
-0.00422846,
-0.005653708,
0.009855149,
0.007274843,
0.0033233266,
0.009186431,
-0.01019964,
-0.028748125,
-0.009267488,
-0.008477184,
-0.011476284,
-0.010875113,
0.032530773,
0.023844192,
0.039690785,
-0.002560042,
0.01568448,
0.007950315,
0.0057550287,
-0.0072208047,
-0.020453319,
-0.007646353,
-0.010915642,
0.010273942,
0.023060644,
0.020872112,
0.007876013,
0.0032000528,
0.023330832,
0.0052315374,
-0.027991595,
-0.031477034,
-0.014401081,
-0.032990094,
-0.029909939,
-0.010300961,
-0.018413391,
-0.005451066,
-0.04158211,
0.0151305925,
0.027667368,
-0.0016582859,
0.006541955,
-0.02165566,
0.020291205,
-0.011429001,
-0.002401306,
-0.013219004,
-0.00832858,
-0.0056976136,
-0.023857702,
0.000012592555,
0.004346668,
0.01144251,
-0.0031156186,
0.014698289,
0.0532813,
-0.02291204,
-0.0009845017,
0.0032372037,
-0.027505254,
0.006646653,
-0.02660012,
-0.03239568,
-0.013164966,
-0.01219904,
-0.011591114,
-0.032855,
0.008038127,
0.019210448,
-0.01644101,
0.02936956,
-0.007909787,
-0.0059137647,
0.026329933,
-0.012239568,
0.024033325,
-0.020777546,
0.036880817,
-0.015144101,
-0.003698214,
-0.016994897,
-0.013914741,
-0.0086325435,
-0.00068011676,
0.03409787,
0.029072352,
-0.023857702,
0.0130704,
0.01108451,
-0.006146803,
-0.036421496,
-0.032179527,
0.028396878,
0.019440109,
0.0023810419,
-0.00024992495,
-0.015117083,
-0.018224258,
0.015414291,
-0.008510958,
-0.016616633,
-0.012354399,
-0.024154909,
-0.009152657,
0.003193298,
-0.0010039215,
0.003416204,
0.005653708,
-0.027937558,
-0.011098019,
0.00062818977,
0.0069033327,
0.014265987,
-0.006872936,
0.038366858,
-0.012192286,
0.008922997,
0.012854248,
0.003070024,
-0.0068121436,
-0.030558392,
-0.015752027,
0.047796458,
0.009422846,
0.0017148567,
0.015549385,
0.003458421,
0.00054671086,
0.01269889,
-0.014414591,
-0.0053362357,
-0.030585412,
0.0018457297,
0.031260885,
-0.014536176,
-0.023628041,
-0.008612279,
-0.028775144,
-0.009199941,
-0.038664065,
-0.024735816,
0.014536176,
-0.039960973,
-0.018778145,
0.0042048185,
-0.0003413249,
0.03858301,
0.038691085,
-0.012111229,
-0.0070249178,
0.036232363,
-0.026073253,
0.002262834,
0.03145002,
0.008288052,
-0.026073253,
0.022020414,
-0.026438007,
-0.022939058,
0.01572501,
-0.01144251,
-0.0032490245,
-0.032936055,
-0.001163502,
0.013752627,
0.011773492,
-0.004208196,
0.0069843894,
0.006937106,
0.015333234,
0.012462474,
-0.020588413,
0.011739719,
-0.01068598,
-0.0017866257,
-0.001453111,
0.003171345,
-0.004809367,
-0.02143951,
0.0004757862,
0.0011128415,
-0.011712699,
0.0029450618,
0.0051808767,
0.007903033,
0.000859117,
-0.0041777994,
-0.016116783,
0.0086325435,
-0.03661063,
0.024154909,
0.0024350798,
-0.030558392,
0.00026406767,
0.010334735,
0.010591415,
-0.00002507957,
-0.026924348,
0.011483039,
-0.007268088,
-0.006322426,
-0.023087662,
-0.0067885024,
-0.023074154,
0.009058091,
0.012415191,
-0.018318824,
-0.023303814,
-0.0048802914,
-0.024992496,
-0.029018315,
-0.0074369563,
0.012577305,
0.0010562707,
0.034178928,
0.00034069162,
0.026316423,
0.006879691,
0.0034026946,
-0.040258184,
0.009199941,
0.008038127,
-0.037340138,
0.016981388,
0.009895678,
-0.061170824,
-0.013333835,
0.0063359356,
0.0007265555,
0.000767506,
0.031720206,
-0.043662567,
-0.0022966077,
0.0027491746,
0.009429601,
0.008943261,
0.007876013,
0.015157611,
-0.013340589,
-0.01057115,
-0.012692135,
0.017737918,
0.0029535051,
0.0043568,
-0.022939058,
0.04104173,
0.014198439,
-0.013705344,
-0.022601321,
0.011064245,
0.01319874,
-0.00008902521,
0.041014712,
-0.006183954,
0.018616032,
-0.010246923,
0.005319349,
0.0021007205,
-0.027005404,
-0.0031426374,
-0.0072140503,
-0.004005554,
-0.01081432,
-0.014022817,
-0.0072072954,
-0.018440409,
-0.023114681,
-0.003134194,
-0.00041436037,
-0.03652957,
-0.03561093,
0.018953769,
-0.00795707,
-0.0034820626,
-0.006153558,
0.0067445966,
-0.034287002,
-0.004144026,
-0.02761333,
0.0020534375,
-0.0308556,
-0.019250976,
-0.0042960076,
-0.016711198,
-0.007612579,
0.018345842,
-0.031774245,
-0.019980486,
0.013495948,
0.2011288,
-0.017697388,
-0.02691084,
0.02069649,
0.0045999703,
-0.017211048,
0.025249176,
0.0072072954,
-0.00808541,
0.015022516,
0.014819874,
0.0044412343,
-0.015860103,
-0.0018744372,
0.0025313345,
-0.010172621,
-0.021507056,
-0.00092202047,
-0.021979887,
0.0017629842,
0.00509982,
-0.02541129,
0.0013999175,
0.00059272745,
0.016049236,
0.0035529872,
-0.016292406,
-0.02164215,
0.014320024,
-0.0019622487,
-0.028288804,
0.032179527,
-0.0061805765,
-0.0022679002,
-0.029207446,
-0.005657085,
-0.008564996,
-0.0039008558,
-0.01132768,
-0.0052720658,
-0.019588713,
0.028558992,
-0.013151457,
0.0040089316,
-0.025235666,
0.010125338,
0.006592615,
-0.0149414595,
0.0023388248,
-0.0020314846,
-0.03863705,
0.018453918,
0.023276795,
0.014981988,
-0.013718854,
-0.0028859577,
0.035232663,
0.0042993845,
-0.00429263,
0.009679526,
0.0008282986,
0.0015417668,
-0.016792255,
0.02115581,
-0.023844192,
0.017535275,
-0.042635847,
0.0060117086,
-0.019507656,
-0.0075652963,
0.0063359356,
-0.011125038,
-0.013590514,
-0.005802312,
0.00021572915,
-0.0084434105,
0.032963075,
0.015265686,
0.014617233,
0.007538277,
-0.006204218,
-0.009503903,
-0.0007611735,
0.008301562,
-0.023884721,
-0.035746023,
0.009503903,
0.025100572,
0.000026530779,
-0.027572801,
0.0074639753,
-0.016765237,
0.0045661964,
0.00013762759,
-0.00080507924,
-0.009861904,
-0.015630443,
0.013468929,
-0.021520566,
-0.00603535,
-0.007538277,
0.059711803,
0.0077544283,
0.030666469,
-0.010530622,
-0.009375563,
-0.014360553,
0.018399881,
0.0018203993,
0.002933241,
0.00063958834,
-0.029207446,
-0.012786701,
-0.02515461,
-0.016994897,
-0.006285275,
-0.0046303663,
-0.014630742,
0.0065014265,
-0.021263886,
-0.022304114,
-0.024911439,
0.0015172809,
0.04952567,
-0.026721707,
0.00097099226,
-0.012469229,
-0.0028099671,
-0.011219604,
-0.046823777,
0.018305315,
-0.0018305314,
-0.01321225,
0.028477935,
0.009395828,
-0.00320343,
0.011469529,
-0.0023388248,
-0.008997299,
0.0056604627,
-0.0017663615,
0.008774392,
0.017967578,
0.00995647,
0.008139448,
-0.03431402,
0.0059103877,
0.004637121,
-0.005954293,
-0.0033334587,
-0.01392825,
-0.018534975,
-0.020723507,
0.008531222,
0.034719307,
-0.007848995,
-0.013394627,
-0.03955569,
-0.0018659938,
0.015468328,
-0.0038501953,
-0.003188232,
0.04660763,
-0.0023810419,
0.007497749,
0.009321526,
-0.17194837,
0.019372562,
0.026964877,
-0.04325728,
0.023587512,
0.007896278,
0.022763435,
-0.017535275,
0.0029957222,
-0.011381717,
0.034935456,
-0.0007223338,
-0.009942961,
-0.015738517,
0.028396878,
-0.0032220054,
-0.01344191,
0.029342541,
0.025532873,
-0.0058732363,
0.014711799,
-0.0073221256,
0.014981988,
-0.0112466235,
-0.0049951216,
-0.006089388,
-0.00798409,
0.019223958,
-0.0037894028,
0.009544431,
0.00036982138,
-0.0019200316,
0.021493547,
-0.0009735253,
0.027329631,
-0.00010617589,
-0.011719454,
-0.012820475,
-0.0010984878,
0.013360853,
0.025816573,
0.040906638,
0.0040291958,
-0.0013078843,
0.0056705945,
0.0076733716,
0.020750526,
-0.0332873,
0.017197538,
0.00039282968,
0.0032051187,
-0.013847194,
0.024978986,
0.007538277,
-0.009139148,
0.01219904,
0.0029180427,
0.020250676,
-0.012178776,
-0.022006907,
-0.0021530697,
-0.017873012,
0.030585412,
0.004596593,
0.013664816,
-0.011233114,
-0.030315222,
0.010848094,
-0.022709398,
0.01594116,
-0.035286702,
-0.00053066836,
0.04231162,
-0.012678626,
0.027829481,
0.024154909,
0.0068121436,
0.0105441315,
0.013131193,
0.008355599,
-0.0024739194,
-0.0006530978,
-0.028180728,
0.0020922772,
0.010375263,
0.011955869,
0.0036948365,
-0.007821976,
0.0144956475,
-0.018251278,
0.023182228,
-0.03261183,
-0.029045332,
-0.026573103,
0.014387572,
0.014671271,
0.0044716303,
-0.029936958,
0.0037860253,
-0.0010072989,
0.0050863107,
-0.016035726,
-0.0076868813,
0.008855449,
0.03112579,
0.00031008426,
0.0043838187,
0.004903933,
0.033044133,
-0.031044733,
0.009598469,
0.0031865432,
-0.00027040023,
0.023736116,
-0.017791955,
0.023357851,
-0.001527413,
-0.00036201123,
0.013421645,
-0.01518463,
0.039447617,
0.008733864,
0.024452118,
0.019359052,
-0.01244221,
-0.021696188,
-0.11164215,
-0.021223357,
0.0021851547,
0.019291505,
-0.035502855,
0.021223357,
-0.012205794,
0.02662714,
-0.02639748,
0.054929454,
-0.019034825,
-0.031585112,
-0.011422246,
0.014144402,
-0.00041372713,
-0.009233714,
0.00785575,
-0.0067074457,
-0.0077274097,
0.026762234,
0.0043196487,
0.003076779,
0.00060665904,
-0.02018313,
0.013833684,
-0.0241414,
-0.033449415,
0.010044281,
0.00820024,
0.008909487,
0.0055321227,
-0.0067040683,
0.009693036,
0.00479248,
-0.030072052,
-0.020223657,
0.00062818977,
-0.016873311,
0.022925548,
-0.0023151832,
0.014792856,
0.012381418,
0.004545932,
0.023074154,
0.009666016,
-0.011158812,
-0.026978387,
0.014252477,
0.00098028,
-0.01595467,
0.0022966077,
-0.014306515,
-0.012232814,
0.005312594,
0.0063359356,
-0.033962775,
0.018494448,
0.014657761,
-0.0048228763,
-0.020480337,
-0.009625488,
0.0050018765,
0.0053801415,
0.030288203,
0.008929751,
-0.0069776345,
0.0035563647,
-0.016994897,
0.0079975985,
-0.0030058543,
-0.007193786,
0.011496549,
-0.0135364765,
-0.025762536,
-0.02266887,
-0.012036926,
-0.026735216,
0.0025414666,
0.017832484,
-0.03234164,
-0.007930052,
-0.012577305,
0.020372262,
-0.009625488,
0.024924949,
0.0065014265,
-0.004522291,
0.008767637,
-0.0037319877,
-0.034476135,
-0.0068763136,
0.051930353,
-0.018102672,
-0.032665867,
-0.030720506,
0.01044281,
0.009517413,
0.009429601,
-0.0027390425,
-0.004610102,
-0.03409787,
-0.011043982,
-0.06922246,
0.025938159,
0.034395076,
-0.012692135,
0.008146203,
-0.010138848,
0.006572351,
0.00010411781,
0.016049236,
0.029747825,
0.0044412343,
0.033935755,
-0.014036326,
-0.0049377065,
-0.0065655964,
0.0010165867,
0.019480638,
0.013968779,
0.024290005,
0.033773642,
0.0014218704,
0.013806665,
0.011361454,
0.0008553175,
-0.0014472007,
-0.009132393,
-0.0030075428,
0.03661063,
-0.027748425,
-0.00046354326,
0.0073491447,
-0.032260586,
-0.020075053,
-0.00062945625,
-0.019156411,
-0.040609427,
-0.0060015763,
0.01644101,
0.018575504,
0.010902132,
-0.004829631,
-0.02759982,
0.01118583,
0.012104474,
-0.009774093,
-0.018494448,
-0.03234164,
0.021493547,
0.013664816,
0.0026748725,
0.0054544434,
-0.014320024,
-0.0052720658,
-0.0338547,
-0.029207446,
-0.001790003,
-0.0064845397,
0.0018659938,
-0.0049917446,
0.0023861078,
0.02788352,
0.01765686,
0.009341789,
-0.014306515,
0.0069978987,
-0.01518463,
-0.014022817,
0.008396127,
0.014306515,
-0.021561094,
-0.009720054,
-0.008970279,
-0.00048254093,
0.0024671645,
-0.003634044,
0.007720655,
-0.014387572,
-0.006322426,
0.0088892225,
0.019196939,
0.0026529196,
0.01644101,
-0.020304713,
0.022290604,
0.0145631945,
0.022223057,
-0.009963225,
0.010746773,
0.0014683091,
0.018791655,
-0.0048938007,
0.014630742,
0.032719906,
0.0072343145,
0.014157911,
0.029180428,
-0.0007523079,
-0.001562031,
0.017494747,
0.026086763,
0.019696789,
-0.007409937,
-0.006089388,
-0.015373763,
-0.02093966,
0.008659562,
-0.025532873,
-0.03704293,
-0.0258571,
0.003341902,
0.01292855,
0.029963976,
0.015333234,
0.0050728014,
-0.01069949,
-0.0055355,
0.019223958,
-0.01691384,
-0.012590814,
0.02637046,
-0.017900031,
0.018129691,
-0.012435456,
-0.0020044658,
0.008274542,
0.014441609,
0.026451517,
-0.010915642,
0.03507055,
-0.024735816,
0.023709098,
-0.0027761934,
-0.033449415,
-0.00068391627,
0.0011246623,
0.011982889,
-0.012232814,
0.025735516,
-0.039663766,
0.09278295,
0.008139448,
-0.009348544,
0.0047350647,
-0.0030514486,
0.012057191,
-0.00015356453,
0.0012344266,
-0.011854549,
-0.023979286,
-0.008254278,
-0.045121588,
-0.0031730337,
-0.025532873,
-0.009733564,
0.019831883,
-0.006943861,
-0.00047451968,
-0.003161213,
-0.046175323,
0.0011677237,
0.008335335,
0.010496848,
0.02187181,
-0.039636746,
-0.012415191,
0.02141249,
-0.0008941572,
0.00069404836,
-0.021736717,
-0.0032811095,
-0.014333534,
-0.031477034,
-0.010719755,
0.009112129,
-0.017778445,
0.00832858,
-0.022871511,
-0.0097808475,
0.023033625,
-0.0013585448,
0.0061771995,
-0.012624588,
-0.034287002,
0.014711799,
0.0081867315,
0.011206095,
-0.010382018,
-0.0062447465
] |
Optical imaging of the dynamics of living specimens involves tradeoffs between spatial resolution, temporal resolution, and phototoxicity, made more difficult in three dimensions. Here, however, we report that rapid three-dimensional (3D) dynamics can be studied beyond the diffraction limit in thick or densely fluorescent living specimens over many time points by combining ultrathin planar illumination produced by scanned Bessel beams with super-resolution structured illumination microscopy. We demonstrate in vivo karyotyping of chromosomes during mitosis and identify different dynamics for the actin cytoskeleton at the dorsal and ventral surfaces of fibroblasts. Compared to spinning disk confocal | [
-0.0132684,
0.014691933,
0.00023942378,
-0.0023686376,
-0.012308187,
0.024562655,
-0.019472854,
-0.0064596157,
-0.011838152,
-0.026402505,
0.034809407,
0.023461431,
0.022575082,
-0.0007747174,
-0.0060567292,
0.01298638,
0.021285845,
0.0021151549,
-0.0025130054,
-0.013751864,
-0.023918036,
0.01838506,
-0.005919076,
-0.0050025093,
-0.004871571,
0.013442984,
0.00014310869,
-0.030243358,
-0.01720326,
-0.004320959,
0.0030233285,
-0.0043679625,
-0.011717287,
-0.028094629,
-0.019351989,
0.0070035127,
0.0065603373,
0.010045307,
0.0072116707,
0.002257844,
-0.0020328988,
0.0111062415,
-0.018505927,
0.00034098478,
0.0021218697,
0.015269403,
0.003871069,
0.005365107,
-0.010824221,
0.0009971444,
0.024938684,
0.023004828,
-0.020184621,
-0.0027497013,
0.010058736,
-0.02683225,
0.01040119,
0.00034476185,
-0.015511136,
-0.033600748,
-0.014289047,
-0.017579287,
-0.020157762,
0.029974766,
-0.010689925,
-0.009044806,
0.008272606,
0.013516847,
0.014544208,
-0.033385873,
0.029598739,
0.018223906,
0.0005938381,
-0.0137921525,
0.024858106,
-0.017565858,
-0.018103039,
-0.0048514265,
0.008218887,
0.008453905,
0.0030569024,
-0.019096827,
-0.013463128,
0.016531782,
0.0066912756,
0.01041462,
-0.005569908,
0.016518353,
0.0114419805,
-0.012603637,
0.016773514,
0.022212483,
0.016545212,
0.015175397,
-0.01447706,
0.0036226225,
-0.013698146,
0.021299275,
-0.013691431,
-0.0154305585,
-0.009199245,
-0.0024408216,
-0.010320613,
-0.027302284,
-0.0051502343,
-0.024240347,
0.026496511,
0.01193216,
0.019177403,
-0.021688731,
-0.008245747,
0.016679507,
0.0072183856,
-0.030995412,
0.011724001,
-0.0028151704,
0.015833445,
-0.009561843,
-0.009817004,
-0.0073459665,
-0.0018314555,
0.0062816744,
0.004112801,
-0.0084606195,
0.0380325,
0.019137116,
-0.016182613,
-0.0037132718,
-0.0075541246,
-0.0023199555,
0.013181108,
0.012966235,
0.001839849,
0.008333039,
-0.019083397,
-0.0030283646,
-0.0099311555,
-0.0041698767,
-0.016786944,
-0.037038714,
0.0012749684,
0.025072979,
-0.021084402,
0.0073795402,
-0.0035353303,
0.023474861,
0.0007008549,
0.011965733,
-0.006805427,
0.0037602752,
0.006798712,
-0.010018447,
0.023018256,
0.02385089,
-0.0067047053,
0.016008029,
-0.004008722,
0.016088607,
-0.033359013,
0.0010558987,
-0.0018062751,
0.013980166,
0.0053080316,
-0.0004175752,
0.010501912,
0.009911011,
-0.0076212725,
0.0049051447,
-0.01071007,
0.0027664884,
-0.010824221,
0.0380325,
-0.007480262,
0.023743453,
-0.009548414,
0.0038811413,
0.004915217,
0.010125884,
-0.018143328,
-0.021447,
-0.00063790387,
0.0058687152,
0.0076212725,
0.008977657,
-0.007359396,
0.021823026,
0.0271277,
0.0048581413,
0.019526573,
-0.022682518,
-0.0014268901,
0.011925445,
0.014571067,
-0.0056370557,
-0.65063506,
-0.029357007,
0.012919231,
-0.041067578,
0.0007432419,
0.04818524,
0.0013505096,
-0.0038240657,
-0.0042000934,
0.01176429,
0.004045653,
0.016773514,
-0.011576276,
-0.030082202,
-0.03164003,
-0.03491684,
-0.0025297923,
-0.019163974,
-0.01778073,
-0.007453403,
-0.019835452,
-0.013436269,
-0.01569915,
0.012066455,
0.013442984,
0.023179412,
0.0398052,
-0.0119455885,
0.0058888597,
0.0374416,
-0.036232937,
0.010522056,
-0.011012235,
-0.013510132,
0.042491112,
-0.015269403,
-0.009709568,
0.0177673,
0.0343528,
0.035077997,
-0.02413291,
0.0008003175,
0.012254469,
0.010918228,
-0.02895412,
0.015860304,
-0.0008582325,
-0.012402194,
-0.0027127701,
-0.006204454,
-0.0024861463,
0.014154751,
-0.01176429,
0.0014931986,
0.027288856,
-0.014745651,
0.015349981,
0.0055598356,
-0.0017223404,
0.0058620004,
-0.000067724824,
-0.0136242835,
-0.017968744,
-0.015537995,
-0.025717597,
0.03378876,
-0.014906806,
0.012308187,
0.022534793,
0.014275617,
0.029813612,
0.024240347,
-0.001922105,
-0.021205267,
-0.0018213834,
0.036259796,
0.043860927,
0.0004977329,
-0.010065451,
0.016169183,
0.00006421006,
-0.0054255403,
-0.04305515,
-0.013704861,
0.016572071,
0.011260682,
-0.019378847,
0.02019805,
0.00005164608,
-0.010616063,
-0.006167523,
0.01506796,
-0.001999325,
-0.03709243,
-0.026362216,
0.02289739,
-0.007453403,
0.0140876025,
0.015443988,
-0.0037502032,
-0.019190833,
0.0028621738,
0.0119455885,
0.01477251,
0.013664572,
0.020345775,
-0.026496511,
0.008118166,
0.037280444,
-0.012697644,
-0.0038039214,
-0.003948289,
-0.018895384,
-0.011912015,
0.010844366,
-0.030914836,
0.015591713,
0.018814806,
-0.011878441,
-0.02711427,
0.010844366,
-0.014302475,
0.02562359,
-0.0046667703,
0.012556634,
0.0021269058,
0.0068390006,
-0.0004163162,
-0.008514337,
0.0046164095,
0.005173736,
0.0031995913,
0.029652458,
-0.029357007,
0.01779416,
0.007943582,
0.013134104,
0.003360746,
-0.0060869455,
-0.03446024,
-0.02295111,
-0.019728016,
0.0013160964,
-0.011126386,
0.0005124214,
0.0014663395,
-0.02350172,
0.0023401,
0.015940882,
-0.013617569,
-0.017122682,
0.004092657,
-0.0059895813,
0.017243547,
0.026308497,
-0.0049790074,
-0.01748528,
-0.025435576,
-0.014262187,
-0.012039596,
0.009085094,
0.0078294305,
-0.02143357,
0.012603637,
0.005281172,
-0.015739437,
0.007332537,
-0.0039751483,
-0.016773514,
-0.02046664,
-0.009696138,
-0.021863315,
-0.020359205,
0.029518161,
-0.001216214,
0.014436771,
0.0035386877,
-0.022655658,
-0.0042806705,
-0.010421335,
0.0013866015,
-0.01477251,
-0.009017946,
-0.01933856,
0.008749355,
0.01631691,
0.0061641657,
0.009353685,
-0.009924441,
0.039885778,
0.021326132,
0.024294065,
0.003800564,
0.024952112,
0.00798387,
-0.010092311,
0.005751207,
-0.008648633,
0.00060726766,
0.024737239,
0.027584305,
-0.001037433,
0.0008712424,
-0.0035319729,
0.019083397,
-0.031022271,
0.006536836,
-0.020950105,
0.0038374953,
0.02137985,
0.00042764738,
0.0049622203,
0.0029444299,
-0.018465638,
0.022575082,
0.019432565,
0.01572601,
-0.016612358,
0.0043142443,
0.011374833,
0.0117777195,
-0.0068893614,
0.033278435,
0.022682518,
-0.0095954165,
-0.011448695,
-0.008991087,
0.012207465,
0.018170187,
-0.025355,
-0.028819824,
-0.0016661041,
0.0019456068,
0.0035655468,
0.013939878,
0.0199026,
0.00813831,
-0.022454215,
0.052912444,
0.02258851,
0.029706175,
0.01568572,
0.002316598,
-0.0068524303,
0.00947455,
0.012019452,
0.023662874,
0.011952303,
0.0031341224,
-0.022803383,
0.0047977082,
-0.0002742567,
-0.014074174,
0.0010458266,
0.013476558,
-0.004522403,
0.015739437,
0.008353183,
0.021823026,
0.023703163,
-0.0035118286,
0.019445995,
0.021594724,
-0.010253465,
-0.014839658,
-0.0010206462,
0.004888358,
-0.013140819,
-0.025180414,
0.0075809835,
-0.01281851,
0.0032650605,
0.009534984,
-0.015511136,
0.003498399,
-0.019647438,
0.024508938,
0.007124379,
0.0054994025,
0.011166675,
-0.023380855,
-0.036420953,
-0.010038592,
0.03776391,
-0.008406901,
-0.039885778,
-0.014047314,
-0.01374515,
0.0017458422,
0.0026154057,
0.0024357855,
-0.0187208,
0.00008949539,
-0.004206808,
-0.018197047,
-0.023165982,
0.025207274,
-0.012489486,
0.0063790386,
0.013362407,
0.0147993695,
0.009615561,
-0.00041484734,
-0.00064881536,
0.0355346,
-0.0020631154,
-0.019634008,
-0.024804387,
-0.0049622203,
-0.035749476,
-0.014517348,
-0.019378847,
-0.025771316,
-0.0010844365,
-0.0048312824,
0.010924943,
-0.0138324415,
0.011139816,
0.0470303,
-0.011549417,
-0.01631691,
-0.0096759945,
-0.010394475,
-0.0077152792,
0.01783445,
0.020735232,
-0.0056370557,
0.007607843,
-0.010978661,
-0.021285845,
0.010757074,
-0.023327136,
0.018747658,
-0.017847879,
-0.0053147464,
0.0036427667,
0.023770312,
0.013590709,
-0.030270217,
0.004508973,
-0.013570565,
-0.012066455,
0.010575774,
0.019351989,
0.009998304,
0.0038744265,
0.027852897,
0.022252772,
0.017874738,
-0.012026167,
0.013604139,
0.00084899965,
-0.004465327,
-0.010193032,
0.0066342,
0.02045321,
0.01630348,
0.019580292,
-0.01598117,
-0.041551042,
0.0049957945,
-0.0076481313,
0.006835643,
0.007889863,
0.0038509248,
0.010763788,
0.023112264,
0.003087119,
-0.01222761,
-0.013053527,
-0.00029335183,
0.020090614,
-0.020775521,
-0.0075742686,
0.0440758,
-0.0094678365,
0.004881643,
-0.036044925,
-0.012335046,
-0.010736929,
-0.023756882,
-0.03169375,
0.0032549882,
-0.0189491,
0.013725005,
-0.013241541,
0.005808282,
-0.013127389,
-0.0144636305,
0.001740806,
-0.013664572,
-0.0019254624,
-0.05124718,
-0.0043545333,
0.010616063,
-0.02503269,
-0.048292678,
-0.016639218,
0.01901625,
0.0065704095,
0.011650139,
-0.00074114354,
-0.000789406,
0.01873423,
-0.02046664,
-0.0020849383,
-0.0132684,
-0.029625598,
-0.02078895,
0.010387761,
0.020104043,
-0.022373639,
-0.010199747,
0.009528269,
0.0016216188,
-0.018331341,
0.004267241,
0.0026187631,
-0.0019489641,
0.004300815,
0.008406901,
0.017001817,
-0.0032482736,
-0.016075177,
0.006375681,
-0.03470197,
-0.004186664,
-0.010374331,
-0.010783932,
-0.0074332585,
-0.0226288,
0.0033070277,
0.006909506,
0.011556132,
-0.00009238065,
-0.0063118907,
0.022118477,
0.00739297,
0.025140127,
0.024508938,
-0.0046365536,
0.027960332,
-0.0055061174,
0.012482771,
0.0063085333,
-0.009998304,
0.019432565,
-0.03193548,
-0.014906806,
0.013160964,
0.0108107915,
-0.02109783,
0.00001323939,
0.0030854403,
0.017552428,
0.03282183,
-0.0009518197,
-0.046305105,
-0.020157762,
-0.014020455,
-0.015269403,
0.019486284,
-0.013093816,
-0.0057209902,
-0.002581832,
0.0028756035,
0.0006643433,
-0.01024675,
0.027691742,
-0.03975148,
-0.014262187,
0.008762784,
0.0036494816,
0.027382862,
0.0039852206,
-0.014047314,
-0.009904296,
-0.006805427,
-0.017633006,
-0.05213353,
-0.015900593,
-0.02078895,
0.033117283,
0.01896253,
0.04498901,
0.016840661,
0.005838499,
0.026093625,
-0.0043679625,
0.0069162208,
-0.008319609,
0.0047574197,
-0.04192707,
0.028121488,
0.009259678,
-0.004569406,
-0.0010760431,
-0.0121134585,
0.012536489,
0.036125503,
-0.015255974,
0.0025381858,
0.003911358,
-0.0325801,
-0.021621583,
0.0006307694,
-0.007473547,
-0.0049957945,
-0.010005019,
-0.0000463477,
0.026402505,
0.025798175,
0.0013169358,
-0.0010500234,
0.019808592,
-0.009998304,
0.029679315,
0.0025029331,
0.022279631,
-0.023944896,
0.0016686221,
-0.012899088,
-0.00097196404,
0.025475865,
0.023233129,
0.008171884,
0.016639218,
0.017162971,
-0.0069497945,
-0.0003877784,
0.011045809,
0.0009266393,
0.0008271766,
-0.011556132,
-0.011408406,
-0.020923246,
-0.031559452,
-0.030082202,
-0.006650987,
0.0106429225,
-0.013805582,
0.029007839,
0.0010785611,
0.0011373154,
0.0056773443,
0.014396483,
0.0047406326,
-0.013664572,
0.019459425,
0.005435612,
-0.013127389,
-0.035051137,
-0.037334163,
-0.0073728254,
-0.019150546,
0.010334042,
0.020936675,
-0.03161317,
-0.019942889,
0.013476558,
0.013966737,
-0.015323122,
-0.05369136,
-0.012153747,
0.009568558,
0.008695637,
-0.017941885,
0.0056437706,
-0.035991207,
0.013953308,
-0.014074174,
0.0038307805,
-0.00022578439,
-0.0028353147,
-0.02836322,
-0.0032382014,
-0.011475555,
0.017122682,
-0.005613554,
0.0023115622,
0.010078881,
-0.009414118,
-0.0059627225,
0.0068121417,
0.004982365,
0.00860163,
0.0147590805,
0.00030657154,
0.021326132,
0.019795164,
-0.009729712,
-0.023958325,
-0.010018447,
0.037549034,
-0.00048094592,
-0.00557998,
0.0111062415,
0.0009182458,
0.017068963,
-0.016518353,
-0.0029242856,
-0.008306179,
-0.018103039,
0.02084267,
0.04077213,
-0.013194538,
0.025771316,
-0.026080195,
-0.006590554,
-0.016169183,
-0.01596774,
0.009367115,
-0.008574771,
-0.045042727,
-0.012267898,
0.021258986,
0.022655658,
0.012288042,
-0.0009845542,
-0.0017475208,
0.012147033,
0.025543014,
-0.016075177,
0.01783445,
0.028443797,
0.008198743,
-0.032338366,
0.005569908,
-0.0072116707,
-0.03107599,
-0.007883148,
-0.024938684,
-0.04219566,
-0.008252461,
-0.0015880448,
0.013859301,
0.0055665504,
-0.012167176,
0.01932513,
0.012395479,
0.014879947,
-0.02714113,
-0.032150354,
0.01325497,
-0.020600937,
-0.0009291573,
0.0129528055,
-0.017042104,
-0.000121285666,
0.004290743,
-0.031747468,
0.01086451,
-0.0053214612,
-0.026644237,
-0.020372635,
0.012012737,
-0.0025784746,
0.0122813275,
0.014383053,
-0.009326826,
-0.0018113112,
0.0006874253,
-0.004508973,
0.005761279,
-0.018667081,
-0.011992592,
0.015121679,
0.009118668,
-0.007480262,
-0.007513836,
-0.0077085644,
-0.033278435,
-0.03290241,
-0.010421335,
-0.0037367735,
0.021796167,
0.023998614,
-0.009326826,
-0.016827231,
-0.00241732,
-0.030995412,
-0.018881954,
0.0033187787,
-0.007117664,
0.008198743,
0.00934697,
0.0007709404,
0.026066765,
-0.019701157,
0.027557446,
0.004717131,
-0.015900593,
0.039348595,
-0.008010729,
0.02348829,
0.012462627,
-0.029733034,
0.0017374486,
0.022225913,
-0.005600124,
0.011515843,
0.00860163,
-0.008406901,
0.004233667,
0.006271602,
-0.0068893614,
-0.0171764,
0.009226104,
0.01571258,
-0.020050324,
0.006144021,
0.01631691,
-0.013805582,
-0.006201097,
0.011287541,
-0.006144021,
-0.004008722,
0.028792966,
-0.019540003,
-0.006996798,
0.015524565,
-0.014383053,
-0.00090985233,
0.017606147,
0.0356689,
0.018062752,
0.024347782,
-0.006761781,
-0.0007977995,
0.015497706,
-0.024764098,
-0.014597926,
0.00086788496,
0.0009711247,
0.03771019,
-0.0070169424,
-0.012328331,
-0.007681705,
0.0033641034,
-0.007869719,
-0.0030887977,
-0.038113076,
0.015497706,
0.0031055845,
0.006392468,
-0.02986733,
0.0044351104,
-0.03462139,
-0.018559644,
0.012382049,
0.012576778,
-0.024025474,
0.011509128,
-0.006875932,
-0.020627797,
0.00534832,
-0.005831784,
-0.013503417,
-0.01536341,
0.0075742686,
0.1845758,
-0.0023652804,
-0.0027144488,
0.023098834,
0.011629994,
0.020560648,
0.021648442,
-0.011972448,
-0.0066241277,
0.02109783,
0.015752867,
-0.007419829,
-0.012133603,
-0.006083588,
0.00019840068,
0.012865514,
0.005821712,
0.0049890797,
-0.019795164,
0.000950141,
-0.006842358,
-0.022252772,
0.009011231,
0.0012489486,
0.034836266,
0.0106429225,
-0.0028974265,
0.012100029,
0.002180624,
-0.009407403,
0.0007214189,
-0.029115275,
0.0081248805,
0.0022376995,
0.0050461553,
-0.008259176,
-0.012758077,
0.005905647,
0.016048318,
0.0063689663,
-0.0123216165,
0.009817004,
0.022534793,
-0.018519357,
0.027664883,
0.02924957,
-0.005640413,
0.009528269,
0.0045022583,
-0.0081651695,
-0.030431371,
0.016048318,
0.0068960763,
0.028443797,
-0.012925946,
0.010528771,
0.003515186,
0.02142014,
-0.0007042123,
0.017512139,
-0.042088225,
0.011435266,
-0.005640413,
-0.00037455867,
-0.025166985,
0.027261997,
-0.01252306,
0.016625788,
0.00723853,
-0.013308689,
0.005717633,
0.003602478,
-0.028416937,
0.0033808905,
0.0035554746,
-0.007896578,
0.026953116,
-0.009145527,
0.03771019,
0.017082393,
0.019029679,
-0.0199026,
-0.010146028,
-0.002048007,
0.0037199866,
-0.0226288,
0.04590222,
0.008635203,
0.011730716,
0.00844719,
-0.0126170665,
0.005103231,
0.01099209,
-0.006684561,
0.025314711,
0.0038744265,
0.0074668326,
0.0018364916,
-0.025301281,
0.00647976,
-0.009326826,
0.051515773,
0.02536843,
-0.018868525,
0.0036461242,
-0.007923437,
-0.03252638,
0.009111953,
0.016679507,
-0.03867712,
0.010193032,
-0.023877747,
0.010501912,
0.0030988697,
0.0014772511,
0.014060744,
0.0029360363,
-0.04603651,
0.044210095,
0.012838654,
0.012872228,
-0.0063286778,
0.00671142,
0.0034849695,
-0.0070102275,
-0.03588377,
-0.018573074,
0.0056101964,
-0.0023854247,
-0.017592717,
0.012610352,
0.016504923,
-0.0063353926,
0.009326826,
0.005355035,
-0.0064831176,
-0.011878441,
0.0059761517,
-0.011240537,
-0.0012648961,
-0.02045321,
-0.006687918,
-0.0071915267,
-0.006909506,
0.011039094,
0.004948791,
0.0000066262523,
0.013275115,
-0.0022091616,
-0.025784746,
0.0067785676,
-0.012831939,
-0.0028991052,
-0.020950105,
0.020278627,
-0.017686723,
-0.015484276,
0.0068121417,
-0.006731564,
0.020278627,
-0.017055534,
0.009024661,
0.01932513,
0.016424345,
-0.0015838481,
-0.011811294,
-0.17028676,
0.013476558,
0.016988387,
-0.01988917,
0.023770312,
-0.0026103696,
0.026039906,
0.010830936,
-0.014597926,
0.009998304,
-0.004173234,
0.031156566,
-0.051623207,
-0.018653652,
0.008876936,
0.009226104,
-0.009890867,
0.049313325,
0.022413926,
-0.012079884,
0.017256977,
-0.029813612,
0.0452576,
-0.024012044,
0.0010349151,
0.010730214,
0.0027815965,
-0.0126170665,
0.00057579216,
-0.042705983,
-0.014597926,
-0.011878441,
0.013134104,
0.0005619429,
0.007869719,
-0.0030837615,
-0.0068020695,
0.0073728254,
-0.015578283,
0.036098644,
-0.002466002,
0.02742315,
0.0037871343,
-0.025220703,
0.004895073,
0.033385873,
-0.006909506,
-0.0021604795,
0.016061747,
-0.025489295,
0.027611164,
-0.048158385,
-0.018908814,
0.01176429,
0.02708741,
-0.0014973953,
-0.012308187,
0.025704168,
0.008944083,
-0.009038091,
-0.0007961208,
-0.0101393135,
0.0183582,
0.0086284885,
-0.039402314,
-0.012858799,
-0.016115466,
0.0022007683,
-0.012590207,
-0.00042177195,
0.006144021,
0.008594915,
-0.0132684,
-0.023609158,
0.027382862,
0.017579287,
0.0011322793,
-0.015940882,
0.011791149,
0.0039449316,
-0.0047809216,
0.016974958,
-0.012355191,
-0.012066455,
-0.016048318,
0.006009726,
0.0012237682,
0.023286847,
-0.0093402555,
0.00051997555,
0.0040557254,
-0.05522233,
0.019741446,
-0.0043914644,
0.021514148,
0.023474861,
-0.0147993695,
0.011535987,
-0.0065435506,
0.002432428,
0.011495699,
-0.0013740113,
-0.00784286,
0.02801405,
0.004394822,
0.001191873,
0.016397486,
0.012711073,
0.05549092,
-0.0004305851,
-0.008514337,
0.0053281756,
0.0024576085,
0.024012044,
-0.0124962,
0.015390269,
0.010166173,
0.020318916,
0.005882145,
-0.028148348,
0.052052952,
-0.0022293061,
-0.03655525,
0.023367425,
-0.0027715242,
-0.010595919,
-0.13719633,
-0.039456032,
-0.015940882,
0.031156566,
0.018586503,
0.01745842,
-0.01325497,
-0.00647976,
-0.0030233285,
0.033305295,
-0.0035521172,
0.005761279,
-0.019714586,
-0.005190523,
0.007204956,
-0.013886159,
-0.005704203,
-0.00027572556,
-0.006553623,
0.025140127,
-0.011582991,
0.0014957166,
0.019795164,
0.0029561808,
-0.009904296,
0.0017256978,
-0.015309692,
0.028792966,
0.007816001,
0.013046812,
0.0065636947,
-0.012086599,
-0.0016963206,
-0.012207465,
-0.0064898324,
0.0012674142,
-0.012167176,
-0.031559452,
0.013275115,
-0.026926257,
-0.015121679,
0.0144636305,
0.041067578,
0.031532593,
-0.011200248,
0.0020312201,
-0.013019953,
0.026953116,
-0.009481265,
-0.009541699,
-0.03889199,
-0.013013238,
-0.023098834,
-0.008950798,
0.023676304,
-0.015457418,
-0.0026221205,
-0.039375454,
-0.021661872,
0.008816503,
-0.014195039,
0.003800564,
-0.0027799178,
0.029088415,
0.019096827,
-0.010367616,
-0.04673485,
-0.029168993,
0.005432255,
-0.017297266,
0.0019271411,
0.015591713,
-0.01418161,
-0.0031274075,
-0.016934669,
-0.006409255,
-0.024723811,
-0.009817004,
0.016786944,
0.010763788,
-0.015645431,
-0.023300277,
0.02957188,
-0.013503417,
0.020278627,
0.017055534,
-0.003971791,
-0.00993787,
0.017633006,
-0.011381548,
-0.0016467992,
0.04184649,
0.0032365227,
-0.011092812,
-0.017874738,
0.011294255,
-0.0071512377,
-0.00739297,
0.023004828,
0.008306179,
-0.045015868,
-0.012019452,
-0.051166605,
0.012147033,
0.029786753,
0.003860997,
-0.00059467746,
-0.012120173,
0.0031374798,
0.0029964694,
0.007876433,
0.004596265,
-0.009111953,
0.011717287,
-0.010340757,
-0.014235328,
-0.03110285,
-0.043162588,
0.03959033,
-0.011307685,
0.038193654,
0.028739247,
0.012489486,
-0.006063444,
0.009837149,
0.027879756,
-0.019781735,
-0.001416818,
-0.025475865,
0.010387761,
-0.012684215,
-0.0067785676,
0.012435768,
-0.011267397,
-0.0035319729,
0.013087101,
-0.004032224,
-0.024038903,
-0.0066342,
0.0144233415,
0.0204935,
0.026335357,
0.0036259799,
-0.04160476,
-0.00096524926,
-0.00066937937,
-0.01688095,
-0.0033154213,
-0.03107599,
-0.000027068947,
0.008984372,
-0.005613554,
0.014665074,
-0.007023657,
-0.0019053181,
-0.020654656,
-0.0065771244,
-0.007661561,
-0.017122682,
-0.0076347017,
0.014906806,
0.00071554346,
0.018277625,
0.0070035127,
-0.0091320975,
0.0045996225,
-0.0060500144,
-0.019083397,
-0.033869337,
-0.005673987,
-0.026308497,
-0.041148156,
-0.028094629,
0.015296263,
0.026671095,
0.021003824,
-0.016706366,
-0.0025885466,
-0.020668084,
0.0063555366,
-0.004552619,
0.022131907,
0.0071646674,
0.006677846,
-0.0075608394,
0.015484276,
0.043887787,
-0.0010399511,
-0.00049521483,
0.051408336,
-0.0010005018,
-0.0039382167,
-0.0042571686,
0.03558832,
0.0014713756,
0.011193533,
0.0066476297,
0.004364605,
-0.006238028,
0.022561653,
0.0132482555,
0.010125884,
0.00062405464,
-0.011092812,
0.017928455,
-0.02350172,
-0.021554435,
0.03137144,
-0.01988917,
-0.024146339,
-0.0040892996,
0.026711384,
-0.00007533141,
-0.0106026335,
-0.008829933,
-0.0009795182,
-0.026791962,
0.030297074,
-0.005234169,
-0.020010037,
-0.00785629,
0.037146147,
0.0073459665,
0.0057142754,
-0.0018515999,
-0.0067181345,
0.024589514,
0.0027043766,
0.026603948,
-0.026039906,
0.01569915,
0.0048447116,
0.032042917,
-0.0032600244,
-0.0132885445,
-0.015833445,
-0.012563349,
-0.022722807,
-0.013980166,
-0.010958517,
-0.005801568,
0.09341598,
-0.008205458,
-0.004085942,
0.0108107915,
-0.046681132,
0.0020664728,
0.010535486,
0.0145039195,
0.010837651,
-0.050575703,
0.033305295,
-0.015336552,
-0.004596265,
-0.005794853,
-0.018331341,
0.020641226,
-0.03225779,
0.0049185744,
-0.027194848,
-0.019150546,
0.021164978,
-0.018613363,
0.013993596,
0.028390078,
-0.014665074,
-0.005744492,
0.008077878,
0.009199245,
0.0015628644,
-0.003004863,
-0.0044451826,
0.006244743,
-0.041443605,
-0.019620579,
-0.017552428,
-0.014409912,
0.0018045964,
-0.006469688,
-0.03045823,
0.021742448,
-0.0065334784,
0.006738279,
-0.00038693903,
-0.007298963,
-0.022789955,
0.0020916532,
-0.000543897,
-0.015927453,
-0.025099838
] |
Kinetochores couple chromosomes to the assembling and disassembling tips of microtubules, a dynamic behavior that is fundamental to mitosis in all eukaryotes but poorly understood. Genetic, biochemical, and structural studies implicate the Ndc80 complex as a direct point of contact between kinetochores and microtubules, but these approaches provide only a static view. Here, using techniques for manipulating and tracking individual molecules in vitro, we demonstrate that the Ndc80 complex is capable of forming the dynamic, load-bearing attachments to assembling and disassembling tips required for coupling in vivo. We also establish that N | [
-0.030212617,
0.005188128,
0.0045468225,
-0.017210063,
-0.02391493,
0.027280934,
-0.027769549,
0.009595831,
0.009663695,
-0.005574947,
0.026154408,
0.01985672,
0.020861093,
0.017440796,
-0.010471264,
0.0024939661,
0.013565818,
-0.0072681294,
-0.02215049,
-0.029561132,
-0.029778294,
0.018173717,
0.006711653,
-0.0501372,
0.003248942,
0.0078517515,
0.018024419,
-0.019585269,
-0.0009933449,
-0.035343062,
-0.006670935,
-0.018078709,
0.0057412116,
-0.03955057,
-0.02297842,
-0.01222213,
-0.0025397735,
-0.028339598,
0.011339911,
-0.00030432324,
-0.009032568,
0.0023463638,
-0.012710744,
0.0064571663,
-0.005931228,
0.018567322,
-0.006287509,
-0.013830484,
-0.0010858084,
0.005768357,
-0.0046995142,
0.03352433,
-0.022136917,
0.0011197398,
-0.0073292064,
-0.026181554,
0.0047673774,
0.0017423831,
0.011842097,
-0.008292861,
-0.032031346,
-0.020833947,
-0.012866829,
0.014766993,
-0.015119881,
-0.0100233685,
0.013749048,
0.0022479626,
0.000112186055,
-0.0026941618,
0.02923539,
0.032085635,
0.005615665,
0.0028485502,
0.03914339,
-0.03537021,
-0.02424067,
0.0012376518,
-0.009093645,
0.025231471,
-0.003213314,
-0.005015077,
-0.0047979155,
0.016707877,
-0.007722812,
-0.005619058,
0.016354987,
0.0016422851,
0.0069491733,
0.008672894,
0.015717076,
0.033795785,
0.012575018,
0.017739393,
-0.020250326,
0.015242035,
-0.0013453844,
0.030456923,
-0.024281388,
-0.002086788,
-0.018730193,
0.014726276,
-0.00093905453,
-0.022449087,
-0.0058226474,
-0.0029842763,
0.03575024,
-0.01844517,
0.012317139,
-0.011000596,
-0.008238571,
0.018906638,
0.003130182,
-0.017182916,
0.013504741,
-0.013348656,
-0.00019287944,
-0.0033422539,
-0.0013835573,
-0.014101936,
0.0059787324,
0.04153217,
0.0018594468,
-0.0092429435,
0.0005174555,
0.000013095442,
0.00031874413,
0.009331166,
-0.011631722,
-0.0006561506,
0.028203871,
0.0074649323,
0.0022208174,
0.01761724,
-0.024227098,
0.021648305,
-0.0050354362,
0.0006892338,
-0.008849338,
-0.035723094,
0.011265261,
0.018933782,
-0.018635185,
-0.0031692032,
0.0029588277,
0.022001192,
0.018133,
0.016110681,
0.013844056,
0.011400987,
0.005171162,
0.0034118134,
0.012310352,
0.012676813,
-0.024851438,
0.03773184,
0.015174172,
-0.008761116,
-0.0015430355,
-0.029778294,
-0.0060092704,
-0.00235824,
0.021702595,
-0.027335225,
0.038600486,
0.026561586,
-0.013796552,
-0.0049743596,
0.013769407,
-0.010844511,
0.008503237,
-0.0010662978,
-0.0069763185,
0.022204781,
-0.009337951,
0.010247316,
0.014929865,
0.02324987,
-0.036347434,
-0.0028587298,
0.01391192,
0.014590549,
0.02272054,
0.005140624,
-0.029181099,
-0.023738485,
0.0059210486,
0.0160021,
0.009989437,
0.007546368,
0.0059855185,
-0.01594781,
-0.0030249942,
-0.013613322,
-0.62195104,
-0.001450572,
0.027755976,
-0.018906638,
0.00316581,
0.009215798,
0.010288034,
0.023412742,
-0.019558122,
0.012412147,
-0.007919614,
0.018580895,
0.014862002,
-0.006226432,
-0.03048407,
-0.02424067,
0.004950607,
-0.016870746,
0.028611049,
-0.0090868585,
-0.02512289,
-0.00204607,
-0.019829575,
0.01347081,
-0.013728689,
-0.011984609,
0.04424669,
0.008740757,
-0.0032438524,
0.019571695,
-0.01756295,
0.008971492,
-0.019042363,
0.0016897892,
0.036266,
0.006219646,
-0.016069964,
0.016857175,
0.0153370425,
0.018879492,
-0.031407006,
-0.0155406315,
0.008435373,
-0.003953021,
0.0005569009,
0.0053985035,
-0.0013487776,
-0.019897439,
-0.005639417,
-0.013681185,
-0.006603072,
-0.007159549,
-0.015445624,
0.018730193,
-0.028421033,
-0.00048394816,
0.02324987,
-0.022421943,
0.0025838846,
0.037650403,
0.0031946518,
0.00020708825,
-0.010437333,
-0.034637287,
-0.03257425,
0.0023548468,
-0.016612867,
-0.007878897,
0.0012054169,
0.025611505,
0.015825657,
0.011550286,
-0.012724317,
-0.0056326305,
0.015703503,
0.026846612,
0.019055936,
-0.0076888804,
-0.0017525625,
0.021051109,
-0.009331166,
-0.009568686,
-0.024037082,
-0.012656453,
0.024824293,
0.0013742262,
-0.012500368,
0.0019374893,
0.013178999,
-0.018513031,
-0.00028163154,
-0.003337164,
-0.003837654,
-0.038329035,
0.0063282265,
0.032438524,
-0.00651485,
0.0052729566,
0.024946447,
-0.031244135,
-0.011475637,
-0.010036941,
-0.023168435,
-0.010511982,
0.0069966773,
0.014794138,
-0.03501732,
0.026656594,
0.05160304,
0.0018221221,
-0.023779202,
-0.013389374,
-0.0050625815,
-0.009779061,
-0.005859972,
-0.024525696,
0.033225734,
0.029208245,
0.024023509,
-0.0025957606,
0.0020308008,
0.010118376,
0.0045468225,
-0.012147481,
0.010797007,
0.01079022,
0.0059414073,
-0.0048216674,
-0.015988527,
-0.028936792,
-0.006070347,
0.021078255,
0.02246266,
-0.00071171345,
0.022055482,
0.038980518,
0.001438696,
-0.02022318,
0.0014878968,
-0.05122301,
-0.021824747,
-0.00018344223,
0.0066811144,
-0.005344213,
0.022693394,
-0.022761257,
-0.043540914,
-0.00042817325,
0.0052831364,
-0.01117704,
-0.0031505406,
0.0046520103,
-0.00079908705,
0.0003128061,
0.0039394484,
-0.0037901497,
-0.016124254,
-0.011333125,
0.007397069,
-0.016585723,
0.0028536401,
-0.0067489776,
-0.037026063,
0.015676359,
-0.017590094,
-0.014862002,
0.011285621,
-0.0145091135,
-0.0005085485,
-0.027294507,
-0.0022309967,
-0.014563404,
-0.035967402,
0.002809529,
-0.0017279622,
0.004085354,
0.018092282,
0.007369924,
0.015594922,
-0.02027747,
0.009677267,
-0.019883865,
-0.028122436,
-0.010416973,
0.036727466,
0.00880862,
0.04204793,
-0.0030266908,
0.0112584755,
0.029941164,
-0.01881163,
-0.004180362,
-0.0033965441,
0.006022843,
0.022340506,
-0.023114145,
-0.0056428104,
0.016816456,
0.004085354,
0.042346526,
0.04033778,
-0.02444426,
-0.006039809,
-0.019218808,
0.00527635,
-0.015187744,
0.0015133454,
-0.01902879,
0.008014623,
0.0056733484,
-0.01433267,
-0.0012664936,
0.012208558,
0.0065996787,
0.01761724,
0.017834403,
-0.016042817,
0.006850772,
-0.018010845,
-0.003337164,
0.0030300838,
-0.030972682,
0.033415753,
0.004787736,
0.00027399693,
0.007973905,
-0.0062332186,
0.025163608,
-0.020671077,
0.0037324661,
-0.03053836,
-0.005710673,
-0.017318644,
0.016517859,
-0.006199287,
0.012921119,
-0.0093990285,
-0.00094584085,
0.052308816,
-0.0116181495,
-0.00013689244,
0.02215049,
0.0014107026,
-0.011400987,
0.0053408197,
0.023114145,
0.023467032,
-0.0045128907,
0.008618603,
-0.0090665,
-0.00577175,
0.0090665,
-0.04033778,
-0.0058294334,
-0.0013657433,
-0.031244135,
0.0078042476,
0.02657516,
0.03865478,
0.015377761,
-0.023087,
-0.037324663,
-0.002706038,
0.013335084,
-0.00155067,
-0.020006018,
0.027715258,
-0.0038342606,
-0.02266625,
-0.0078042476,
-0.0060533816,
0.018323015,
0.0019069508,
-0.0046689757,
0.018363733,
-0.00818428,
0.010050514,
0.016789312,
0.012982196,
0.009466891,
-0.0068643447,
-0.021349706,
0.013565818,
0.029724004,
-0.009256516,
-0.025977964,
-0.04096212,
0.024824293,
-0.014481968,
0.011000596,
0.0035763811,
0.0062569706,
-0.008964705,
-0.005503691,
-0.022625532,
-0.012249275,
0.019368106,
-0.023887783,
0.013823697,
-0.009114004,
0.007946759,
0.0074445736,
-0.0090665,
-0.0037901497,
0.035967402,
-0.008876483,
0.010810579,
-0.0072613433,
0.012344284,
-0.031434152,
0.010613777,
-0.003776577,
-0.020263897,
-0.0041260715,
-0.009344738,
-0.007186694,
-0.0068609514,
0.011156681,
0.02814958,
0.0013411429,
-0.010030154,
-0.0088832695,
-0.003549236,
-0.01240536,
0.03591311,
0.024430688,
-0.0057174596,
0.021200407,
-0.02668374,
0.0022649283,
-0.0052017006,
-0.02809529,
0.026670167,
0.0033066256,
-0.0053645717,
-0.0311627,
0.00004005509,
-0.011007382,
-0.01011159,
0.023127718,
-0.007437787,
-0.0038512265,
-0.0022276037,
0.008822192,
0.015771367,
-0.008218212,
0.025421487,
0.041993637,
0.00073631376,
0.012283207,
0.009772275,
0.034067236,
0.0030674085,
-0.030782666,
0.02339917,
0.014264807,
0.0209561,
0.026900902,
-0.028963936,
-0.03189562,
0.00041141958,
0.023317734,
0.009941933,
0.01855375,
-0.0016914858,
-0.011156681,
0.020861093,
-0.009446532,
0.021661876,
-0.016612867,
0.015418478,
0.00048776547,
-0.010220171,
0.00044619935,
0.04362235,
-0.031678457,
0.003861406,
-0.011475637,
0.0032319764,
-0.006487705,
-0.00071595487,
-0.008245357,
0.00030389908,
-0.014563404,
0.0014658412,
-0.020236753,
0.0032319764,
-0.0065894993,
-0.009276875,
-0.0031166093,
-0.031298425,
-0.015513486,
-0.03414867,
-0.016246406,
0.008157135,
-0.0199653,
-0.039333407,
-0.018051563,
0.017047191,
0.012866829,
0.017915837,
-0.02361633,
0.0072206254,
0.036700323,
-0.012459651,
0.013009341,
-0.010525554,
-0.04207507,
-0.029751148,
0.028801067,
0.020141745,
0.016015673,
-0.0047911294,
0.018675903,
0.004173576,
-0.0015421872,
0.0067218323,
-0.0026805894,
-0.01024053,
-0.0015243731,
0.013443665,
0.020942528,
-0.0005085485,
-0.009575472,
-0.008985064,
-0.034827303,
0.00041460065,
-0.0037155005,
0.0064537735,
-0.011082032,
-0.00046740656,
0.020141745,
-0.0034219928,
0.002573705,
0.008638962,
-0.027063772,
-0.011109176,
0.0013988265,
0.011624935,
0.04316088,
-0.00046443756,
0.014889147,
-0.008896842,
0.01024053,
-0.008326793,
-0.019191662,
0.01881163,
-0.00093820627,
-0.0098672835,
0.041776475,
-0.02027747,
-0.021051109,
-0.00006680266,
0.005232239,
-0.017549377,
0.014373388,
-0.01376262,
-0.025272189,
-0.0055376226,
-0.0070645404,
0.0011960857,
0.006005877,
0.01347081,
-0.0004171455,
-0.011088817,
0.010464478,
0.00935831,
-0.007118831,
0.004624865,
-0.038546197,
-0.03184133,
0.0026924654,
0.0014726275,
0.02481072,
-0.0016219262,
-0.012412147,
-0.00048564473,
-0.017590094,
-0.0016702786,
-0.029533986,
0.0033897578,
-0.008143563,
0.041477878,
0.017047191,
0.04611971,
-0.007397069,
0.016449997,
-0.011808165,
0.019734567,
-0.02626299,
-0.0021207193,
0.015825657,
-0.025367197,
0.025964392,
0.0027077345,
0.0070238225,
-0.0085710995,
-0.004943821,
0.011109176,
0.019530978,
-0.0055579813,
-0.029778294,
-0.0056733484,
-0.045251064,
0.0010459388,
0.0029995455,
-0.015567777,
-0.005432435,
-0.035614513,
0.0066845077,
0.01917809,
0.018037992,
0.007397069,
-0.00981978,
0.043486625,
0.012758248,
0.03298143,
-0.017847974,
-0.004607899,
-0.013484382,
-0.008326793,
-0.0019086475,
-0.014224089,
0.02387421,
-0.00034419275,
0.017277924,
0.016137827,
-0.015961383,
-0.007960333,
0.0120864045,
-0.01855375,
-0.012873615,
-0.0059380145,
-0.04039207,
-0.023087,
-0.02381992,
-0.0028247982,
-0.027145209,
0.00347289,
0.010396615,
-0.005367965,
0.000943296,
0.0041226787,
-0.012961837,
0.038220454,
0.016640013,
0.00017485331,
-0.016911466,
0.013294366,
0.0018170323,
-0.0067896955,
-0.0032472454,
-0.01625998,
-0.024674995,
0.00037218624,
0.032438524,
0.024661422,
-0.014712703,
-0.01073593,
-0.012113549,
-0.014129081,
-0.013606535,
-0.02928968,
-0.004068388,
0.0047096936,
0.012860042,
0.0032201004,
0.0092429435,
-0.0033303779,
0.022856265,
-0.0013165426,
-0.013219717,
0.0077431705,
-0.01688432,
-0.01625998,
0.015676359,
-0.015106308,
0.02631728,
-0.013056845,
-0.018540177,
0.007790675,
-0.014590549,
0.010681639,
0.0031725962,
-0.007166335,
0.008998636,
-0.0041362513,
-0.0077838884,
0.025679367,
0.004984539,
-0.032275654,
-0.020467486,
-0.021892611,
0.044518143,
-0.008075699,
0.0053476063,
0.0067082597,
-0.011842097,
0.018798057,
0.0054290416,
0.006810054,
-0.017847974,
-0.03903481,
-0.01079022,
0.025502924,
-0.018065136,
0.017495086,
-0.028068146,
-0.015662786,
0.012079618,
-0.025923675,
-0.02923539,
0.018798057,
-0.040717814,
-0.022530522,
-0.010389828,
0.01407479,
0.0002267049,
0.002594064,
0.004451814,
-0.029832585,
0.03653745,
0.0020172284,
0.016354987,
0.014427679,
-0.0053645717,
-0.032682832,
-0.011394201,
-0.014712703,
-0.019829575,
0.010457692,
-0.0012334104,
-0.031868476,
0.008326793,
-0.010532341,
-0.00015629701,
0.020358907,
-0.029724004,
-0.0031759895,
0.013708331,
0.011713157,
-0.012968623,
-0.015622067,
0.006219646,
-0.04017491,
-0.004730053,
0.030456923,
-0.031569876,
-0.015879948,
0.0015600012,
-0.032791413,
-0.0030708017,
-0.02048106,
-0.0013369016,
-0.00981978,
-0.008306433,
-0.013321511,
0.006487705,
0.0037019278,
-0.015214889,
-0.012323924,
0.014685558,
0.0035526291,
-0.0046621896,
0.011400987,
-0.020114599,
0.01172673,
0.027660968,
-0.011631722,
-0.02361633,
-0.00601945,
-0.031569876,
-0.05252598,
0.005663169,
-0.013579391,
0.030456923,
-0.016830029,
-0.006647183,
-0.022856265,
-0.011869242,
-0.034528706,
-0.005971946,
-0.001017097,
-0.009996223,
0.00732242,
0.0008576189,
0.0011748786,
-0.009093645,
0.009704412,
0.035994545,
-0.0027874736,
-0.01662644,
0.04649974,
-0.007431001,
0.01917809,
-0.001229169,
-0.02569294,
0.0045434292,
0.03488159,
0.0059142625,
-0.015404906,
0.0052017006,
0.026032254,
-0.0029791866,
-0.010634135,
-0.0031352716,
-0.0080553405,
0.021078255,
0.02699591,
-0.026222272,
0.0009721378,
0.013939065,
0.02016889,
-0.021295415,
-0.000014818527,
0.00014739,
-0.023806348,
0.010905587,
-0.008957919,
-0.025462205,
0.018092282,
-0.032845702,
0.008143563,
0.028448178,
0.022937702,
0.030782666,
0.02391493,
-0.008666107,
-0.006653969,
-0.014862002,
-0.022503378,
-0.011747089,
-0.0016575543,
0.0069254213,
0.020128172,
-0.0035119113,
0.021376852,
-0.013667612,
-0.0009424477,
-0.009046141,
-0.004723266,
-0.00943296,
0.024145663,
0.019802429,
-0.0007880593,
-0.013233289,
0.025923675,
-0.027063772,
-0.013735475,
0.008191067,
0.015092736,
-0.036347434,
0.005744605,
0.0032862667,
-0.028991083,
0.0012435899,
-0.019164518,
-0.004255011,
-0.0029248963,
0.02413209,
0.1869762,
0.0076074447,
-0.0018831989,
0.01148921,
-0.0019052543,
-0.025340052,
0.008265716,
-0.00601945,
-0.011679226,
-0.0037663977,
0.01939525,
0.0072477707,
-0.0063926964,
-0.0037256798,
0.028556759,
-0.0027467557,
-0.005456187,
-0.020752512,
-0.010206599,
0.0051372307,
0.016857175,
-0.014373388,
0.030049745,
0.008978277,
0.018838774,
-0.01568993,
-0.020196036,
0.00071341003,
-0.026846612,
0.004540036,
-0.040690668,
-0.0063485857,
0.001810246,
-0.008462518,
0.011251689,
0.009337951,
-0.00943296,
-0.00094838574,
0.015771367,
0.010260888,
0.019938156,
-0.024607131,
0.029941164,
-0.00060101185,
0.0051270514,
0.0088832695,
0.003189562,
-0.02532648,
-0.011299193,
0.0042923363,
-0.05852507,
0.007159549,
0.01047805,
0.011183826,
-0.012778607,
-0.0012003272,
-0.012656453,
0.013464023,
0.0004724963,
0.017237207,
-0.033470042,
0.01433267,
-0.020657504,
0.034691576,
-0.012866829,
0.009527968,
-0.005547802,
0.0023158255,
0.03919768,
-0.022381224,
0.0034711936,
-0.0035560222,
-0.016775738,
-0.022571241,
0.014183371,
-0.017739393,
0.049322844,
-0.0035628085,
0.03518019,
0.026656594,
0.00006844622,
0.0022971632,
-0.0084150145,
-0.021431142,
0.0029690072,
-0.021444716,
0.02793242,
-0.0024770002,
-0.019843148,
-0.019883865,
0.02079323,
0.0038953375,
-0.0015413389,
-0.013694758,
0.0030148148,
0.009080072,
0.008360724,
-0.02569294,
-0.010233743,
-0.012887187,
-0.019938156,
0.061511043,
0.021933328,
-0.003620492,
-0.013036487,
0.005188128,
-0.0011918443,
-0.005367965,
0.011740303,
-0.039061956,
0.014346243,
-0.00969084,
0.020453915,
-0.00034567725,
-0.019055936,
0.01965313,
0.015092736,
-0.0331443,
0.016721448,
-0.0069288146,
-0.0009645032,
-0.047775567,
-0.0008389566,
0.017128626,
0.0026992518,
0.00613821,
0.000114094706,
-0.011475637,
0.017739393,
-0.014454824,
0.017657958,
0.009161508,
-0.004180362,
0.0025770983,
-0.006765943,
0.0020087454,
0.032139927,
-0.02299199,
-0.0030232975,
0.0035322702,
0.0031233956,
0.003445745,
0.02115969,
0.0061653554,
0.005778536,
-0.016965754,
0.023059854,
0.019055936,
-0.02418638,
-0.03767755,
0.00948725,
-0.010647708,
0.009697625,
0.0067727296,
-0.006114458,
-0.025190754,
-0.0271995,
-0.0250686,
-0.0015023176,
0.01636856,
-0.01824158,
0.002122416,
0.04283514,
0.010532341,
-0.0077431705,
-0.004584147,
-0.17134055,
0.023942074,
-0.0015048624,
-0.0067896955,
0.008265716,
0.01526918,
0.000074649324,
0.012649667,
0.00047037555,
-0.000020637252,
0.00006765095,
0.017359361,
-0.03501732,
-0.025421487,
0.008462518,
0.03387722,
-0.0085235955,
-0.007756743,
0.01334187,
0.019585269,
0.005320461,
-0.021702595,
0.020942528,
0.000014792018,
0.010674853,
0.039170537,
0.0050931196,
0.0000048445186,
-0.013708331,
-0.018988073,
-0.018540177,
-0.010545913,
0.01495701,
0.005982125,
0.014481968,
0.016789312,
-0.013267221,
0.01391192,
-0.005598699,
0.022557668,
0.023697767,
0.04408382,
0.014766993,
-0.022164064,
0.01991101,
0.043785222,
-0.021295415,
0.0055104773,
0.0015879947,
-0.0032201004,
0.035614513,
0.0034338688,
0.022394797,
0.019938156,
0.016979327,
0.023195582,
-0.012826111,
0.02626299,
-0.004244832,
-0.00070323056,
0.013199357,
-0.022082627,
0.009548327,
-0.018078709,
-0.017264353,
-0.022639103,
-0.012262848,
0.005768357,
-0.024199953,
0.0026721065,
-0.0075802994,
-0.0074988636,
0.016097108,
-0.017956555,
0.013979782,
-0.006104279,
-0.0066370033,
-0.011977823,
0.006497884,
-0.0048182746,
-0.024987165,
0.018689476,
-0.020073881,
-0.03162417,
-0.010749502,
0.0020257111,
0.00068753725,
-0.0023327915,
-0.0017092999,
0.009181866,
-0.0028197085,
-0.044382416,
0.022435514,
-0.005612272,
0.03575024,
0.02778312,
-0.006647183,
-0.018852348,
-0.021539724,
-0.013402946,
0.0015905396,
-0.012887187,
-0.024661422,
0.046146855,
0.033062864,
0.025000736,
0.009283661,
-0.0014607515,
0.02668374,
0.0012427416,
-0.023684194,
-0.022639103,
0.024729285,
0.044518143,
-0.012656453,
0.057819296,
0.010131949,
0.022503378,
-0.0009721378,
-0.00060101185,
0.06759157,
0.0012690385,
-0.016382134,
-0.005235632,
0.008381083,
-0.024783576,
-0.12812538,
0.0018611434,
-0.0021868858,
0.033442896,
0.0066573624,
0.01725078,
-0.017454369,
0.024362825,
0.008672894,
0.029588277,
-0.034827303,
0.012819325,
0.016707877,
-0.00732242,
-0.01563564,
-0.020155318,
0.022381224,
-0.032384235,
-0.013009341,
0.012059259,
-0.00453325,
0.0015761186,
-0.010769862,
-0.023168435,
0.02470214,
0.0014454824,
-0.027905274,
0.022639103,
0.011658867,
0.013769407,
-0.008177494,
-0.022896983,
0.032031346,
-0.019938156,
-0.03132557,
-0.0070916857,
-0.0038478333,
-0.02543506,
0.027959565,
-0.02064393,
-0.01818729,
-0.0056292377,
0.009622976,
0.01782083,
0.0037460388,
-0.0024413723,
-0.013979782,
0.0075667268,
-0.01469913,
0.013674399,
-0.010973451,
0.011842097,
-0.037867565,
0.00020995122,
0.016341416,
-0.018010845,
-0.004064995,
-0.0124460785,
-0.01954455,
-0.014807711,
-0.017549377,
-0.009609404,
0.013701544,
0.011882815,
0.022516951,
-0.021811174,
-0.0140205,
-0.00583622,
0.033062864,
-0.014875574,
0.0019476687,
0.020426769,
-0.026439434,
0.006090706,
-0.02996831,
0.017101482,
-0.031434152,
-0.023589186,
0.029452551,
-0.00022288761,
-0.019110227,
-0.024960019,
0.01180138,
-0.029588277,
0.06221682,
-0.0014336064,
-0.0095076095,
0.0045196773,
0.03173275,
-0.010057299,
-0.013117922,
0.024674995,
-0.0011782717,
-0.013131495,
-0.0021682235,
0.02183832,
-0.005171162,
-0.007302061,
0.009073286,
0.0038105086,
-0.04101641,
0.00008477576,
-0.057493553,
0.013606535,
0.006355372,
-0.004132858,
-0.0074988636,
-0.0069288146,
-0.0013861022,
0.012751462,
0.0029113237,
0.040744957,
-0.029099664,
-0.0021648305,
-0.007709239,
-0.0024990558,
-0.039170537,
-0.023534896,
0.015974956,
-0.0103830425,
0.017657958,
0.022598386,
-0.013925492,
-0.009568686,
0.026290134,
0.04128786,
-0.020358907,
0.005432435,
-0.0045536086,
0.017657958,
-0.010613777,
0.013925492,
0.032818556,
-0.032818556,
0.00050982094,
0.015404906,
0.0017542591,
-0.0096026175,
-0.037568968,
0.044762447,
0.015079163,
0.030456923,
-0.017766539,
-0.029696858,
-0.017318644,
0.0041124993,
-0.018404452,
0.0012096583,
-0.030918393,
-0.0049132826,
0.0066403965,
-0.018662332,
0.039007664,
0.00060652575,
0.016925037,
-0.014889147,
-0.013165426,
-0.0050354362,
0.0047945227,
-0.0045705745,
-0.002945255,
-0.034963027,
0.008876483,
0.018295871,
0.024037082,
0.01079022,
-0.0000049737496,
-0.015242035,
-0.030429779,
0.006871131,
-0.004329661,
-0.03835618,
-0.018594468,
0.032655686,
0.02121398,
-0.006131424,
-0.025190754,
-0.0112109715,
-0.018363733,
0.00095262716,
0.00001854304,
0.01227642,
0.002709431,
0.01321293,
-0.015879948,
0.00967048,
0.009704412,
-0.010763075,
-0.00010147642,
0.042129364,
0.004421276,
0.011156681,
-0.0052084867,
0.02381992,
0.008557527,
-0.0015956293,
0.007003464,
0.015282752,
-0.017006474,
-0.01902879,
0.00036539996,
0.005595306,
0.0034067237,
0.0092429435,
0.0026754995,
-0.017657958,
0.0028146189,
0.044382416,
-0.033388607,
-0.01855375,
0.000111337766,
-0.0044552074,
0.0061585694,
0.0072952746,
0.0037222868,
0.003776577,
-0.009494036,
0.00044492693,
-0.00087712955,
-0.021974046,
0.0005429042,
0.028583905,
0.023711339,
0.02721307,
0.0076888804,
0.002222514,
0.049757168,
0.0050048977,
0.034800157,
-0.018852348,
0.020141745,
-0.009460106,
0.028421033,
0.008815407,
-0.033850074,
-0.0074988636,
-0.016151398,
-0.0076278034,
-0.011407774,
0.0012300173,
-0.025896529,
0.09158793,
0.026480151,
-0.020861093,
0.021308988,
-0.022055482,
0.028882502,
0.022109773,
-0.022489805,
-0.0038715852,
-0.025597932,
0.00508294,
-0.0009280268,
0.024471406,
-0.007946759,
0.0007982388,
0.019612413,
-0.0022309967,
0.029561132,
0.004088747,
-0.017115055,
0.0068032676,
-0.01985672,
0.005924442,
0.044273835,
0.00490989,
0.008903628,
0.0050184703,
0.0078042476,
-0.0028163153,
-0.016870746,
0.017277924,
-0.014441251,
-0.028366743,
0.0033558265,
-0.0045434292,
0.017888693,
-0.006131424,
-0.032139927,
0.01315864,
0.027077345,
0.0067693363,
0.011584218,
-0.010973451,
-0.0096026175,
-0.008801834,
0.0015608495,
0.0032506387,
-0.01605639,
-0.024267817
] |
OBJECTIVE To determine whether myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) were predictive of a demyelination phenotype in children presenting with acquired demyelinating syndrome (ADS). METHOD Sixty-five children with a first episode of ADS (12 acute disseminated encephalomyelitis, 24 optic neuritis, 18 transverse myelitis, 11 other clinically isolated syndrome) were identified from 2 national demyelination programs in the United Kingdom and France. Acute serum samples were tested for MOG-Abs by cell-based assay. Antibodies were used to | [
-0.024886798,
0.01002657,
-0.009210075,
-0.042901967,
-0.021490175,
0.023475893,
-0.0077338503,
-0.0070414613,
-0.016290728,
-0.0014043731,
0.015088846,
0.0084197065,
-0.0115354555,
0.009203543,
-0.038120564,
0.010274786,
0.029054193,
0.021764517,
-0.0146316085,
0.015389317,
-0.016970053,
0.023162358,
-0.027408138,
-0.021660006,
0.013900028,
-0.016081706,
0.01663039,
-0.042875838,
-0.0134297265,
0.005770994,
0.016617326,
-0.029864157,
-0.008674453,
-0.0029393856,
0.003040631,
-0.017910656,
0.018929644,
-0.0021049266,
0.024507944,
-0.0070937173,
0.02100681,
0.015258677,
-0.008811625,
-0.0021718794,
0.008321728,
0.013560366,
-0.02416828,
-0.017087629,
-0.013965348,
0.014827567,
0.022012733,
-0.001321907,
-0.0070283976,
0.002622585,
-0.015650595,
-0.018968835,
0.012404207,
0.019739607,
-0.0076619983,
-0.051262885,
0.010046166,
0.010353169,
-0.014762248,
-0.01337747,
-0.0019465265,
0.01221478,
-0.0018828397,
0.006943482,
-0.0016852478,
-0.010875727,
0.043163244,
0.0368403,
-0.009301523,
-0.019439137,
0.042196512,
-0.013416662,
-0.012136396,
-0.013717133,
-0.005679546,
-0.0014362164,
0.029132577,
-0.01902109,
-0.0019416275,
0.018981898,
-0.005352948,
0.010764684,
0.007688126,
0.021189705,
-0.008831221,
-0.0015031691,
0.00610739,
0.029655134,
0.013403598,
-0.015807362,
-0.011653031,
0.017479546,
0.01078428,
0.033835594,
-0.02064102,
0.0155068915,
-0.012293164,
0.00942563,
-0.006950014,
-0.026336895,
-0.019817991,
-0.008341323,
-0.0037526155,
0.0035827844,
0.015376252,
-0.013586493,
-0.009922059,
0.029890286,
0.004219651,
-0.034201384,
-0.015154165,
0.008080045,
0.012025353,
0.013521174,
0.004294769,
0.010281318,
-0.01218212,
0.032215666,
0.01400454,
-0.036134847,
0.023110103,
0.018563854,
-0.03767639,
-0.013900028,
-0.011653031,
0.0021588155,
0.0023368115,
0.007204761,
0.011679159,
-0.0075966786,
0.011777138,
0.022757376,
-0.021450983,
0.0029393856,
-0.019282369,
-0.02947224,
-0.003038998,
0.026140936,
0.0067736506,
0.010006975,
-0.0009838777,
0.023044784,
0.03302563,
0.0044352063,
0.01018987,
0.0027744535,
-0.020784723,
-0.018916579,
0.00826294,
0.015389317,
0.01516723,
0.015859619,
0.013677941,
0.028087461,
-0.047213063,
-0.011254581,
-0.020431995,
-0.010118019,
-0.015859619,
-0.010536064,
-0.01400454,
0.01652588,
-0.022130307,
-0.0017979242,
0.015284805,
-0.008008192,
-0.03143183,
0.039322447,
-0.0123911435,
0.004095544,
-0.0021816774,
0.014696928,
0.014984335,
0.0138739,
-0.027068475,
-0.021777581,
-0.016147025,
0.028688403,
0.016983116,
-0.022012733,
0.0053660115,
0.022051923,
0.018550789,
0.0051439246,
-0.018576916,
-0.02369798,
0.0008687517,
0.01473612,
0.015938003,
-0.024050705,
-0.6387742,
-0.02658511,
0.017675506,
-0.0015774702,
0.01184899,
0.020484252,
0.0018926377,
-0.010392361,
-0.008276003,
0.03550778,
-0.018981898,
0.012025353,
-0.016369112,
-0.015454636,
0.0025050098,
-0.01775389,
-0.00039763356,
-0.002632383,
0.030151565,
-0.010091891,
-0.018263383,
-0.0027221977,
0.00483039,
0.013847772,
-0.0023351784,
0.0020787988,
0.009027179,
-0.017035373,
-0.010268253,
0.035533905,
-0.029237088,
0.027643288,
0.009680376,
0.011724883,
0.04985198,
-0.013704069,
-0.00074382784,
0.025200332,
-0.005911431,
0.042823583,
-0.017897593,
-0.012469526,
0.012443399,
-0.006956546,
-0.006721395,
0.043633547,
0.0035795185,
0.01878594,
0.0048728483,
-0.0043470245,
0.018067423,
0.022195628,
-0.021424854,
-0.022483034,
0.01105209,
-0.007786106,
0.005548907,
-0.015310933,
0.0143050095,
-0.0006638112,
0.0071133133,
0.017492611,
-0.009628121,
-0.024311984,
-0.011528923,
-0.0033606975,
-0.017688569,
0.0030618599,
0.006721395,
-0.003455411,
0.012769997,
0.029028066,
-0.005503183,
0.03401849,
0.020027013,
0.017205203,
0.006159646,
0.0064829784,
-0.0006013493,
-0.012306227,
0.0146316085,
0.0031941324,
-0.018942706,
-0.007348464,
0.031248935,
-0.018825132,
-0.015859619,
0.03229405,
0.0058232495,
-0.016800221,
0.00046744396,
0.012828785,
0.0027597565,
-0.055338833,
-0.0014419319,
0.012482591,
-0.03772865,
0.019974759,
0.008478494,
-0.00975876,
-0.026741877,
-0.00043233464,
0.008850817,
-0.002847938,
0.021163575,
0.008844284,
-0.036030333,
0.016512815,
0.032398563,
-0.022744313,
-0.0045429836,
-0.00091447553,
0.013233767,
-0.012175588,
0.013050872,
-0.028714532,
-0.0106601715,
0.012600166,
-0.011300305,
-0.01460548,
0.0010973706,
-0.011470135,
-0.009451757,
0.012430335,
-0.007877554,
-0.009941655,
0.007844893,
-0.02037974,
0.0059996126,
-0.007681594,
-0.007348464,
-0.01400454,
0.0041347356,
-0.01510191,
0.035168115,
0.0011545253,
0.02516114,
-0.008112704,
0.0017930252,
-0.042144258,
-0.021882093,
0.0060649323,
-0.0070283976,
-0.0092753945,
0.0015382784,
0.000335784,
-0.0034848049,
0.0074595073,
-0.0056501525,
0.012378079,
0.008811625,
0.014422585,
0.012038417,
0.015193357,
-0.0074791033,
-0.023475893,
-0.02386781,
-0.004761805,
0.016356047,
0.006950014,
-0.017688569,
0.010927983,
0.017179076,
0.0058265156,
-0.023789428,
-0.035742927,
-0.0058199833,
0.03341755,
-0.030256076,
-0.023292998,
-0.020523444,
-0.02419441,
-0.018015167,
0.003919181,
0.011254581,
0.0015627734,
-0.00052092446,
-0.0074529755,
-0.01811968,
0.0042719073,
0.012410739,
0.00922967,
0.0049838917,
-0.0047879326,
0.04580216,
0.0034880708,
0.012286631,
0.018733684,
-0.00736806,
0.028035207,
0.010627512,
0.043267757,
-0.009497481,
0.0068455026,
-0.015206422,
-0.020693274,
0.008609134,
-0.011489731,
0.008367451,
0.02738201,
0.032346305,
-0.03216341,
0.018929644,
0.013481982,
0.022626737,
-0.020902298,
0.014762248,
-0.033313036,
0.0039355108,
0.008569942,
0.0063654026,
-0.02602336,
0.0070349295,
-0.003664434,
-0.021281151,
-0.011319901,
0.0051733186,
0.011639967,
-0.01181633,
-0.0143050095,
-0.004954498,
0.027852312,
0.025696762,
-0.0034292832,
-0.002890396,
0.0325292,
0.010764684,
0.022483034,
-0.0014443814,
-0.0006740175,
-0.009399502,
0.0062249657,
0.016238471,
0.014827567,
-0.0038114034,
0.0078122336,
-0.0005050028,
-0.004317631,
0.03232018,
-0.015310933,
-0.010170274,
0.014945143,
0.016016385,
-0.0005527678,
-0.004918572,
-0.022156436,
0.008622197,
0.00889654,
-0.014331138,
0.027172986,
-0.03375721,
-0.0008295599,
-0.0024886797,
0.005023083,
0.004507058,
-0.0027499585,
0.005490119,
0.008354387,
0.008387047,
0.04224877,
0.039505344,
0.009288458,
0.0044646002,
-0.0016640188,
0.0122801,
0.001313742,
0.0078710215,
0.003243122,
-0.005431331,
-0.014709991,
-0.029419983,
0.0089096045,
0.00896186,
-0.031118296,
-0.01473612,
0.01095411,
0.005506449,
0.012338888,
0.033704955,
0.02585353,
-0.021189705,
-0.021869028,
0.0029638805,
0.000515209,
-0.023345254,
-0.004043288,
-0.02001395,
-0.015154165,
0.0032757819,
-0.026140936,
0.006662607,
0.005075339,
-0.017975977,
0.011692222,
-0.010751619,
-0.004036756,
0.027225243,
0.0026258512,
-0.013070468,
-0.007570551,
-0.004477664,
-0.007949405,
-0.016552007,
-0.013318683,
0.004092278,
0.024155218,
-0.020418933,
-0.01138522,
-0.014762248,
-0.011587711,
0.02154243,
-0.011509327,
-0.010470744,
0.015010462,
-0.0063686687,
0.015075782,
-0.0089292005,
0.00033415097,
0.027172986,
0.012776529,
-0.014879823,
-0.029001938,
-0.0072243568,
-0.0025588984,
0.023972323,
0.031771492,
-0.012658954,
0.007283144,
0.008439302,
0.014892887,
-0.0012271935,
-0.039479215,
0.041073013,
0.0046507614,
-0.021202767,
0.016983116,
0.0023204817,
-0.00024964366,
0.005078605,
0.020954553,
-0.0015864517,
-0.023645723,
-0.002691171,
-0.0007450526,
-0.005506449,
0.0061335177,
0.0054737893,
0.026480598,
0.007818766,
-0.028897427,
-0.006306615,
0.029446112,
-0.010797343,
-0.032241795,
-0.024651647,
0.001840382,
-0.0013472184,
0.017179076,
-0.0008030238,
-0.014866759,
0.021411791,
0.007283144,
0.011437476,
0.011822862,
0.031614725,
-0.008034321,
-0.009608525,
0.007531359,
0.006479712,
0.010705896,
0.0047911983,
0.026807196,
0.011097814,
-0.015232549,
0.019373817,
-0.020536507,
-0.009595461,
-0.00021167658,
0.017649377,
-0.021019872,
-0.02675494,
-0.010771215,
0.0146708,
-0.0073549957,
-0.02193435,
-0.013188044,
0.005722004,
-0.009105563,
-0.025618378,
-0.033678826,
-0.008432771,
-0.0049479655,
-0.028244229,
-0.008106172,
0.004307833,
-0.009138223,
-0.03080476,
-0.008413175,
0.013272959,
0.028610019,
0.032607585,
-0.01792372,
0.022535289,
0.026637366,
-0.010020039,
0.004654027,
0.0012043316,
-0.0034456132,
0.020131525,
0.038225077,
0.02688558,
0.0048075286,
-0.015519956,
0.005352948,
-0.0032937448,
-0.0066364794,
-0.007779574,
0.015781235,
0.012515251,
-0.0103139775,
0.0144879045,
0.03153634,
-0.024690839,
-0.01258057,
-0.0089096045,
-0.020562636,
-0.0031827013,
-0.027643288,
-0.012110269,
-0.006943482,
-0.013135788,
-0.008426239,
-0.012175588,
-0.02425973,
-0.008269471,
0.0120449485,
0.006688735,
-0.009673844,
0.0039681704,
0.011430944,
0.0018044561,
0.02462552,
0.02277044,
-0.005529311,
-0.011999225,
-0.010640576,
0.023815555,
0.00089977856,
-0.024756158,
0.027408138,
0.010634044,
-0.017270524,
0.0042229174,
-0.04776175,
0.0009936757,
0.030857017,
-0.016120898,
-0.0066299476,
-0.016565071,
0.00063605036,
0.0019873513,
-0.0014729588,
0.005480321,
-0.004892444,
0.018890452,
0.011914309,
-0.0048205922,
-0.009040244,
0.052517023,
-0.033208527,
-0.025422418,
0.01682635,
-0.03190213,
0.02147711,
-0.009177415,
0.015428509,
-0.0113525605,
-0.0030275672,
-0.015572212,
-0.020601828,
0.004046554,
0.012926765,
0.037362855,
0.01809355,
0.051498037,
-0.012155992,
0.019556712,
0.017806144,
0.012351952,
0.0049904236,
0.00033068086,
0.01380858,
-0.014840631,
-0.013508109,
0.006584224,
-0.013142319,
0.017139884,
-0.032503072,
0.017270524,
0.025971105,
-0.014788375,
-0.017231332,
0.015938003,
-0.031275064,
-0.0052255746,
0.007942873,
0.004229449,
0.01798904,
-0.051785443,
-0.026859453,
0.036056463,
0.010973706,
0.015376252,
-0.016865542,
0.03289499,
0.00023106836,
0.019399945,
0.013717133,
-0.0012835317,
0.004046554,
-0.010170274,
0.006097592,
-0.021294216,
0.01566366,
0.009797952,
0.00044294907,
0.01616009,
0.0026307502,
-0.007165569,
-0.000071086186,
-0.014866759,
-0.0120645445,
-0.010268253,
-0.035429396,
-0.012358483,
-0.020536507,
-0.030726377,
-0.03030833,
0.01719214,
0.02313623,
-0.024024578,
-0.0000339101,
-0.02725137,
-0.03657902,
0.018746749,
-0.015807362,
0.023972323,
-0.018080488,
0.012051481,
0.012776529,
-0.013612621,
-0.020706339,
0.007361528,
0.007185165,
0.009151287,
0.037101578,
0.00939297,
-0.017283587,
0.003481539,
-0.010607916,
-0.0021359536,
-0.008393579,
-0.036474507,
0.030830888,
-0.00019289718,
-0.012234376,
-0.007570551,
0.0005735884,
-0.037415113,
0.038904402,
-0.004925104,
-0.020340549,
0.0009373374,
0.0071721007,
-0.018080488,
0.034645557,
-0.007283144,
0.011783671,
-0.0023515085,
-0.016552007,
-0.0025539994,
-0.031771492,
0.0040400224,
0.008243344,
-0.0020085801,
0.034593303,
-0.003893053,
-0.004683421,
0.008334791,
0.016042514,
0.013416662,
0.0069761416,
-0.011463604,
0.025344037,
0.013900028,
-0.0053300858,
0.0028708,
0.0043372265,
0.014527096,
0.00065278856,
-0.013677941,
-0.02167307,
-0.021895157,
0.0026977027,
0.026480598,
0.00092672295,
-0.009811016,
0.033966232,
-0.019987822,
0.0023139496,
-0.0122082485,
-0.02957675,
0.0033247718,
-0.035403267,
0.005101467,
0.011241517,
-0.0009944921,
0.00028618184,
0.0061857738,
-0.0046409634,
0.019648159,
0.0075901467,
-0.017675506,
0.010072295,
0.02098068,
0.0047977306,
-0.013351343,
-0.000024418334,
-0.014161306,
-0.031222807,
0.012502187,
0.012822253,
-0.027956823,
-0.015454636,
-0.0016852478,
0.0013872267,
-0.011457072,
-0.03315627,
0.0037428176,
0.0068259067,
0.004673623,
0.0020951286,
-0.014474841,
0.01902109,
-0.010947579,
-0.003084722,
0.003065126,
-0.0010941046,
0.0024217272,
0.014644672,
-0.008276003,
-0.005130861,
-0.03399236,
-0.019661224,
-0.016956989,
0.025801273,
-0.020209908,
0.008040853,
-0.016473623,
-0.00936031,
0.0005250069,
-0.010901854,
0.02220869,
0.0041543315,
-0.018145807,
-0.014683864,
-0.009490949,
0.0052419044,
-0.019282369,
-0.006535234,
-0.013638749,
-0.0162646,
-0.029419983,
-0.0151802935,
-0.033678826,
0.021398727,
0.014879823,
-0.006290285,
-0.012175588,
0.013240299,
-0.04371193,
0.018616108,
-0.01895577,
0.002054304,
0.013481982,
0.04164783,
-0.0037428176,
0.0078906175,
0.00069932884,
0.020196846,
-0.029367728,
-0.01473612,
0.016212344,
-0.008537282,
0.007361528,
-0.002042873,
-0.02246997,
-0.019203985,
0.016943924,
-0.0042065876,
-0.007897149,
0.024782287,
0.0030079712,
0.012730805,
-0.027355881,
0.0113525605,
-0.0043992805,
-0.011189261,
0.005072073,
-0.017936785,
0.006567894,
-0.011757542,
0.002875699,
0.006531968,
-0.0130835315,
0.02960288,
-0.02220869,
-0.0039616385,
-0.021764517,
0.002642181,
-0.009850208,
0.0068912264,
0.014161306,
0.023946194,
-0.009190479,
-0.0039518406,
0.0073549957,
0.0054933853,
0.008903072,
-0.0028087462,
-0.008733241,
-0.0068389704,
0.0055521727,
-0.034201384,
-0.007720786,
-0.007897149,
0.011679159,
-0.03670966,
0.007387656,
-0.014095987,
0.015572212,
-0.023057846,
0.031092167,
0.0058722394,
-0.020392803,
-0.00899452,
0.011999225,
0.004333961,
0.0024952118,
0.009837144,
0.007185165,
-0.018838195,
-0.013952283,
-0.0044058124,
0.009935123,
0.012567506,
-0.0012916967,
-0.0037134239,
-0.016382176,
-0.017701633,
0.1864485,
-0.0064503183,
0.0059996126,
-0.020706339,
-0.023410574,
-0.0030324662,
0.027721671,
0.005738334,
0.007936341,
0.015114974,
0.028270358,
-0.009464822,
-0.011293773,
0.0072962083,
-0.0072243568,
-0.011411348,
-0.015323997,
-0.019269306,
0.0042621093,
-0.034697812,
0.01915173,
0.00740072,
0.007139441,
0.0021931082,
0.0024854138,
0.013730196,
-0.0070545254,
0.020497315,
-0.00029148906,
0.035351012,
-0.01689167,
0.012887573,
-0.0024935787,
0.02190822,
0.00330191,
0.0035795185,
-0.042065874,
-0.012665486,
0.0002543385,
0.03020382,
0.015062718,
-0.013325214,
-0.028244229,
0.019099474,
-0.015284805,
0.026062552,
0.0005307224,
-0.026637366,
-0.023854747,
0.017414227,
-0.03007318,
0.006982674,
-0.017570993,
-0.00859607,
0.019661224,
-0.029681262,
0.007309272,
0.015023527,
-0.0087854965,
0.018211126,
-0.011378688,
-0.00532682,
-0.021215832,
0.06317719,
0.010059231,
0.02725137,
0.0047454746,
-0.03992339,
-0.00023025187,
-0.0034358152,
0.00650584,
-0.0049936897,
-0.0029214227,
0.008210684,
0.019896375,
-0.0067736506,
0.025108885,
0.023097038,
0.0014868393,
-0.0023449764,
0.0025115416,
0.019347688,
-0.031222807,
0.013096596,
-0.033861723,
-0.03232018,
0.0059865485,
0.024651647,
-0.013148852,
0.015310933,
-0.012665486,
-0.005555439,
-0.008589538,
0.026467534,
-0.02081085,
-0.0025360365,
-0.007341932,
0.0076424023,
-0.00569261,
-0.028766787,
-0.031039912,
0.08251182,
-0.0016664683,
0.017766953,
-0.015689787,
0.014514033,
-0.009980847,
0.000035007266,
0.008341323,
-0.004102076,
0.012724274,
-0.039270192,
-0.0068520345,
-0.013116192,
-0.010118019,
0.035533905,
0.0029442846,
-0.009099032,
0.002843039,
0.006930418,
-0.0009936757,
-0.037258346,
-0.006963078,
0.007851426,
-0.008524219,
-0.002658511,
-0.017675506,
0.014866759,
-0.005297426,
-0.025513867,
-0.01218212,
-0.027852312,
0.020706339,
0.018080488,
-0.016591199,
0.011195793,
-0.016382176,
0.017858401,
-0.027695544,
0.020340549,
-0.0035958483,
-0.011744479,
0.024246665,
-0.0037264877,
0.015141102,
-0.011620371,
0.021816773,
0.024285857,
-0.026545918,
-0.0036187102,
-0.03192826,
-0.010261722,
-0.0037232218,
-0.016878605,
0.007786106,
-0.02399845,
-0.018576916,
-0.019099474,
-0.010411957,
0.004036756,
-0.020131525,
0.02160775,
0.00700227,
0.0041184057,
-0.0063882647,
0.00006685061,
-0.16356048,
0.0033084417,
0.0017587324,
-0.01337747,
0.012998616,
-0.020092333,
0.021581622,
-0.0073941876,
-0.025735954,
-0.00036558608,
0.03772865,
0.009177415,
-0.015075782,
-0.00009262127,
-0.0014958207,
0.0043633548,
-0.019595904,
0.037415113,
-0.0040073623,
0.014252754,
0.009928592,
-0.038225077,
-0.0029916414,
-0.013717133,
-0.010856131,
0.0015399115,
0.000615638,
0.0384341,
-0.011986162,
-0.027120732,
-0.009575865,
-0.016199281,
0.026807196,
0.018184999,
0.017544866,
0.010006975,
-0.0052288403,
0.016447496,
0.008805092,
0.008635262,
0.013913092,
0.0016019652,
-0.0044188765,
0.0069696098,
0.0021604483,
0.004706283,
0.035351012,
-0.01015721,
0.011189261,
-0.011228453,
0.03339142,
-0.026101744,
0.010268253,
0.010118019,
0.015337061,
0.0053856075,
0.03485458,
0.023815555,
0.022130307,
-0.016983116,
-0.005382342,
-0.024651647,
0.01895577,
-0.014905951,
-0.00022943538,
-0.033678826,
-0.0041282037,
-0.0013659978,
-0.041360423,
0.0043764184,
-0.025148077,
-0.0026928037,
0.014866759,
-0.033077884,
0.0336527,
0.021046001,
-0.010353169,
0.0050394135,
-0.0062706894,
-0.015245614,
-0.005908165,
0.017048437,
-0.03435815,
0.024155218,
-0.0058134515,
-0.0035370607,
0.012038417,
0.021268088,
-0.0070545254,
0.0008981456,
-0.015141102,
-0.017766953,
0.025644505,
-0.008093108,
0.016904732,
0.028531635,
-0.02240465,
0.0068389704,
0.0065972875,
0.0030896207,
0.015467701,
-0.018524662,
-0.024416497,
0.008445835,
0.0064829784,
-0.024756158,
0.009484418,
0.0071133133,
0.017714698,
-0.023083976,
-0.007779574,
0.018041296,
0.014618544,
0.022535289,
0.002642181,
0.014095987,
0.010444617,
-0.00062135345,
0.01175101,
-0.0025360365,
0.05857869,
-0.010464213,
-0.0008687517,
-0.0005282729,
-0.0039681704,
-0.01184899,
-0.11120022,
-0.017414227,
0.007681594,
0.011914309,
-0.009895931,
0.011568115,
0.007583615,
0.032189537,
-0.025905784,
0.02546161,
-0.016251536,
-0.015519956,
0.00007414804,
-0.019491393,
0.023279933,
-0.018315637,
0.013886964,
-0.017910656,
-0.034175258,
0.039479215,
-0.006077996,
-0.025618378,
-0.012776529,
-0.0017848603,
0.007844893,
-0.0049838917,
-0.015323997,
0.034462664,
0.008491558,
0.019765735,
0.0075966786,
-0.020418933,
0.024743095,
-0.00539214,
-0.020170717,
0.010914918,
-0.0027123997,
-0.025879657,
0.03694481,
0.010699363,
0.0023907002,
0.016538942,
0.00043682536,
-0.0021865764,
0.0029050927,
0.011541988,
-0.018498532,
-0.002459286,
0.019308498,
-0.032712094,
0.012077609,
-0.0018730419,
-0.0062151677,
-0.00046213673,
0.013638749,
0.0062216995,
-0.0018795738,
0.020889234,
-0.01775389,
0.009504014,
0.012103736,
0.013351343,
-0.0070283976,
-0.009719568,
0.016473623,
-0.001445198,
-0.042301025,
-0.029054193,
0.0027336285,
-0.021686133,
0.018746749,
-0.0020592029,
-0.0000525109,
-0.021137448,
-0.0053758095,
0.022025796,
0.013743261,
0.00018411985,
-0.0047781346,
-0.017466482,
-0.017244395,
-0.005868973,
0.015872682,
-0.004219651,
0.03974049,
0.0104968725,
0.020105397,
-0.012221312,
0.0015766538,
-0.025030501,
0.01663039,
0.05045292,
0.012959424,
-0.025840465,
-0.005486853,
0.013860836,
0.005927761,
-0.01616009,
0.023959259,
0.029315472,
-0.0114832,
-0.025317907,
-0.05157642,
0.017388098,
0.023828618,
-0.0049512316,
0.018145807,
-0.011528923,
0.012169057,
-0.027852312,
0.013370939,
0.011979629,
-0.010078827,
-0.02227401,
-0.012802657,
0.015846554,
-0.019060282,
-0.046194077,
0.044025466,
0.010914918,
0.027669417,
0.036265485,
0.00057971216,
0.018772876,
0.005114531,
0.05144578,
-0.0229664,
0.027434265,
-0.04102076,
0.026154,
0.0054150014,
-0.0023008857,
-0.008635262,
-0.047082424,
0.007165569,
0.01682635,
-0.007884085,
-0.013233767,
0.0040073623,
0.007178633,
0.0050459453,
0.043032605,
-0.014984335,
-0.021699198,
0.026114808,
-0.00655483,
0.004892444,
0.0068193744,
-0.023645723,
0.022143371,
-0.00014676516,
-0.034227513,
0.021464046,
0.008713645,
0.0035533905,
-0.030517355,
-0.03265984,
0.026833324,
0.014226627,
0.002643814,
-0.0047814003,
-0.008040853,
0.022783505,
-0.019870246,
0.01032051,
-0.0030014394,
0.006545032,
0.0039322446,
-0.0361871,
0.017662441,
-0.004614835,
-0.016186217,
-0.035403267,
-0.0012876142,
0.010444617,
0.008987988,
0.010229062,
-0.003058594,
-0.005284362,
-0.008106172,
-0.0009920426,
0.0074072517,
-0.00043192637,
-0.009530141,
-0.013704069,
0.036892556,
0.0123911435,
0.0038571272,
-0.008798561,
0.016591199,
-0.028819043,
-0.005352948,
-0.00074872683,
0.018054359,
-0.015428509,
0.013240299,
-0.0037820095,
-0.008191088,
0.0016076806,
0.005127595,
0.022561418,
0.031849876,
-0.0077338503,
0.0053888736,
0.005506449,
-0.012227844,
-0.003055328,
0.025801273,
-0.041151397,
-0.034279767,
-0.019308498,
0.0021277885,
0.00370036,
0.025513867,
-0.016617326,
0.007740382,
-0.016813286,
0.013886964,
0.013991475,
-0.010287849,
-0.020366676,
0.011842458,
0.008086576,
0.006479712,
-0.012763466,
-0.017714698,
0.007341932,
0.00783183,
0.019269306,
-0.022091115,
0.02462552,
0.0072766123,
-0.0002062673,
-0.029890286,
-0.0146316085,
0.00021882093,
0.01267855,
-0.053326987,
0.010372765,
0.020183781,
-0.01111741,
0.086483255,
0.016408304,
-0.010627512,
-0.004412344,
-0.023070911,
0.029028066,
-0.008308663,
0.01596413,
0.020575698,
-0.014919015,
0.015088846,
0.0010067396,
0.019935567,
-0.027878439,
-0.044391256,
-0.011039026,
-0.007322336,
0.021202767,
-0.016316855,
-0.020366676,
0.018028231,
-0.036474507,
0.01811968,
0.0034880708,
0.010758151,
0.0013096596,
0.007884085,
-0.026441406,
-0.008524219,
-0.024521008,
0.009386438,
0.0146316085,
-0.04812754,
-0.022548353,
0.0013537504,
-0.036160976,
-0.0029671465,
-0.037780903,
0.0027679214,
0.006518904,
-0.0155068915,
0.031353448,
-0.002861002,
0.016721837,
-0.0044058124,
-0.034175258,
-0.03976662,
-0.009125159,
-0.0019465265
] |
CONTEXT Blood type and crossmatch incompatibility will exclude at least one third of patients in need from receiving a live donor kidney transplant. Kidney paired donation (KPD) offers incompatible donor/recipient pairs the opportunity to match for compatible transplants. Despite its increasing popularity, very few transplants have resulted from KPD. OBJECTIVE To determine the potential impact of improved matching schemes on the number and quality of transplants achievable with KPD. DESIGN, SETTING, AND POPULATION We developed a model that simulates pools of incompatible donor/recipient pairs. We designed a mathematically verifiable optimized matching algorithm and compared it with the | [
0.0016925689,
-0.0013394861,
0.042507045,
-0.01884022,
-0.019841192,
0.038640276,
-0.011476902,
0.008727657,
-0.046291545,
0.00079443614,
-0.019100746,
0.016824562,
0.017894095,
0.0088922,
-0.01947097,
-0.0034691235,
0.014507243,
-0.013458279,
0.00329601,
-0.021267235,
-0.011188951,
-0.003047481,
-0.009187006,
0.0066605797,
-0.022556158,
0.034773506,
0.042589318,
-0.012471018,
-0.0069656707,
-0.01885393,
0.002783526,
-0.0080352025,
-0.02643664,
-0.010126275,
0.007726684,
-0.010523922,
-0.009358406,
0.006314353,
0.037296504,
-0.0135953985,
0.028068362,
0.0015323104,
0.007418165,
-0.01413702,
0.0038084942,
0.011579742,
-0.0006907395,
-0.009673781,
-0.028493432,
0.016934259,
0.0017448456,
-0.0070822225,
-0.008693377,
0.0060229744,
0.00434326,
-0.020567926,
-0.001957381,
0.014233004,
-0.020814741,
-0.019032188,
-0.0054299324,
0.009097879,
-0.010222259,
0.00272525,
-0.03628182,
-0.0017739836,
-0.010208547,
0.004130725,
0.021815713,
-0.0043226923,
0.028932216,
0.026971405,
-0.0075072926,
0.0070753666,
0.012155644,
-0.010290818,
0.006578308,
0.009646357,
-0.006907395,
0.008000923,
0.0009829755,
-0.04343946,
-0.004329548,
0.027684428,
0.0046517793,
-0.003846202,
0.023118349,
0.019662937,
0.034608964,
0.007856947,
0.016166389,
0.043987937,
-0.0015168845,
0.014006757,
-0.01219678,
0.021486627,
0.017935231,
0.023282891,
0.004432388,
-0.02538082,
-0.017318193,
0.016097829,
-0.018716812,
-0.019566953,
-0.03318292,
-0.0068011275,
-0.0029275015,
-0.021993969,
0.021555185,
0.016399493,
-0.02396849,
0.049829226,
0.005186545,
0.00723991,
0.003308008,
-0.014932314,
-0.010078283,
-0.017962655,
-0.034087908,
-0.020293687,
0.031098703,
0.0038941938,
-0.0007095934,
-0.042507045,
0.018113486,
0.021472914,
-0.023502283,
-0.007445589,
-0.013663959,
0.006118958,
0.0030114872,
0.025065444,
0.0023550275,
0.019141883,
-0.021678593,
0.014068461,
-0.052928127,
-0.01051021,
-0.021322083,
-0.041245546,
-0.0045043756,
0.021623746,
0.012320187,
-0.009468102,
-0.009598365,
0.024270153,
0.026189825,
-0.0020122286,
-0.002233334,
0.006653724,
-0.0033457158,
0.020705044,
0.0071027903,
-0.009618933,
0.010914712,
-0.015014585,
0.0044803796,
0.010880432,
0.010976416,
-0.0037159384,
-0.02461295,
-0.014191869,
-0.0026806863,
0.0019916608,
0.015727608,
0.014534667,
-0.0134034315,
0.02967266,
0.0039661815,
-0.03093416,
-0.00660916,
0.0324699,
-0.035157442,
0.015206553,
0.016481765,
-0.010962704,
0.012992073,
-0.0022281918,
-0.04236993,
-0.015124281,
0.003026913,
0.012916657,
0.009797188,
0.03746105,
-0.018922491,
-0.015933286,
0.010270251,
-0.0011638018,
0.004086161,
0.0070822225,
0.006125814,
0.00924871,
-0.0066365837,
-0.02059535,
-0.6388672,
-0.017235922,
-0.0039593256,
-0.021952832,
0.012539579,
0.008851063,
0.013053777,
0.0029206455,
-0.009694349,
0.035047743,
-0.0037605024,
0.01912817,
-0.0064720404,
-0.015014585,
-0.014712922,
-0.025901875,
0.029837204,
-0.016070405,
0.021459201,
0.0048540304,
0.010955849,
-0.019114459,
0.006358917,
0.026889134,
-0.018826507,
-0.0048643146,
0.02461295,
0.024571816,
-0.011387775,
0.009852036,
-0.018127197,
0.021280946,
-0.003613099,
-0.011017552,
0.05912593,
-0.014520955,
-0.004641495,
0.018895067,
-0.0023138917,
0.022185935,
-0.009193863,
-0.02369425,
0.015659047,
-0.0021733441,
0.0070273746,
0.02221336,
-0.0056561795,
-0.010352522,
-0.0020070868,
0.000342156,
0.006406909,
0.021047844,
-0.017400464,
0.019992024,
0.00074730127,
-0.012854953,
0.006338349,
-0.015453368,
0.00070702244,
0.005316809,
0.005488208,
-0.0034485555,
-0.008761936,
-0.04365885,
-0.00165229,
-0.0021236383,
-0.013136049,
0.024407271,
-0.0020979284,
-0.003311436,
0.003325148,
0.015329961,
-0.0033611418,
-0.0067976993,
0.018977338,
0.010654185,
0.019210443,
-0.0057110274,
-0.022377903,
0.00850141,
-0.007109646,
0.00076187024,
-0.0028349457,
0.0073427493,
0.04618185,
0.014534667,
-0.028383737,
0.026820574,
0.018346589,
0.0030851888,
0.0039764657,
-0.009961732,
-0.011230087,
-0.031948846,
-0.014013614,
0.031674605,
-0.016413204,
-0.0056527513,
0.035376832,
-0.032305356,
-0.014178157,
-0.016824562,
0.010297675,
-0.012539579,
-0.0005064852,
0.016084118,
-0.050021194,
-0.0061463816,
0.046483513,
-0.03268929,
0.0030783329,
-0.018552268,
0.0045420835,
-0.00025538506,
0.044454142,
-0.024037048,
0.009927452,
0.009653213,
0.010565057,
-0.032305356,
0.029590389,
-0.0044255317,
0.00048034676,
-0.017578721,
0.007637556,
0.0123133315,
0.004151293,
-0.013897061,
0.01700282,
-0.005752163,
-0.012429883,
-0.0056013316,
0.017551295,
0.002754388,
0.020581637,
-0.01700282,
-0.010318243,
0.00072459085,
-0.019745208,
-0.01674229,
-0.008542545,
-0.018291742,
-0.011778565,
0.021404354,
0.0032514462,
0.0037125105,
-0.012416171,
-0.0246678,
0.008947047,
-0.014863754,
-0.0029275015,
-0.019045899,
-0.019745208,
0.010667898,
-0.02347486,
-0.009673781,
-0.006067538,
0.0013026353,
-0.007822667,
-0.011497471,
-0.003558251,
0.015247689,
-0.02459924,
-0.0026549764,
-0.008672808,
-0.027190797,
0.0069176788,
-0.0012237915,
0.0012674984,
-0.024133032,
-0.0014354698,
-0.018922491,
-0.0137393745,
0.010482786,
-0.021843137,
-0.018099774,
-0.006290357,
-0.015233977,
0.015453368,
0.01848371,
0.0028589417,
-0.020691333,
-0.017907808,
-0.009008751,
0.019676648,
0.0026601183,
0.015302536,
0.0119773885,
-0.0145895155,
0.03277156,
-0.00014643934,
0.01729077,
-0.015343673,
0.007164494,
-0.008569969,
-0.0089813275,
-0.016001847,
0.013753086,
0.004665491,
0.022336766,
0.046483513,
-0.03159233,
0.029480694,
-0.0122653395,
0.016001847,
-0.02538082,
-0.0004987722,
-0.007966643,
0.01884022,
0.020307397,
-0.0066777198,
-0.009756053,
-0.0055464837,
-0.024338711,
0.005241393,
0.034060486,
-0.026669743,
0.011497471,
-0.0088922,
0.005831007,
-0.035157442,
-0.0035308271,
0.032744136,
0.0017585576,
0.00028409448,
-0.021472914,
0.016989106,
-0.0014860326,
0.018332878,
-0.014301565,
-0.021500338,
0.004422104,
-0.0005771874,
0.010661041,
0.009618933,
-0.0026344084,
0.030193714,
-0.0043466883,
0.029151605,
0.015165417,
0.0075415727,
0.0148774665,
0.008467129,
-0.0029480692,
-0.0014620367,
-0.023036076,
0.025764754,
0.017702127,
-0.025970433,
0.013773654,
0.0099823,
0.012971505,
-0.02503802,
-0.0021236383,
0.009474957,
-0.027574733,
0.015453368,
0.013142904,
0.018250605,
0.014987161,
0.012697266,
0.010640473,
-0.004672347,
-0.024503255,
0.012292763,
-0.018812796,
0.011497471,
-0.02531226,
-0.009365262,
0.0196218,
-0.0012992073,
-0.030467954,
0.003059479,
-0.04311037,
-0.010311387,
0.017606145,
0.006307497,
0.00977662,
0.017743263,
-0.009406398,
-0.014452396,
0.0019436689,
0.027245644,
0.040697068,
-0.016001847,
-0.022460174,
-0.023639401,
0.005800155,
-0.0035445392,
0.01596071,
0.01849742,
-0.003280584,
0.020622773,
0.0015648763,
0.0037365064,
-0.04585276,
0.029590389,
-0.016330933,
0.0068216952,
-0.011655157,
-0.0038050662,
0.011394631,
-0.029261302,
-0.029864628,
0.040532526,
-0.0027698139,
0.0029394994,
-0.033621702,
-0.004178717,
0.0002915932,
0.014356412,
0.0064994646,
-0.008206602,
-0.0110724,
-0.008645385,
-0.004305552,
-0.005217397,
0.033265192,
0.020019447,
0.008796216,
-0.010798161,
-0.014260428,
-0.0050391415,
0.010222259,
0.053257216,
0.023324028,
0.004764903,
0.024297576,
-0.002229906,
-0.013663959,
0.0097012045,
-0.04182145,
0.034691233,
0.015823592,
-0.006297213,
-0.0060846778,
0.013519983,
0.010030292,
0.0072536217,
0.008144898,
-0.0053236648,
-0.018593404,
-0.017469024,
0.0045660795,
-0.000099358076,
-0.03225051,
0.030659921,
0.032661866,
-0.009008751,
0.0012546434,
0.024037048,
0.024297576,
0.016495476,
-0.0026824002,
-0.022131087,
0.02860313,
0.015055722,
0.014767771,
-0.010078283,
0.01848371,
0.02313206,
-0.016756004,
0.024023337,
0.014205581,
0.009653213,
0.0053648003,
0.023324028,
0.008138043,
0.02609384,
-0.023090925,
0.0010583912,
-0.0018408293,
-0.013705094,
-0.015700184,
0.032195657,
-0.016056694,
-0.015727608,
-0.021952832,
-0.011298647,
0.019045899,
-0.0062869294,
-0.0062560774,
0.008494553,
-0.011099824,
-0.0007108789,
-0.0368303,
0.021774577,
0.012176212,
-0.021459201,
0.0060126903,
-0.02713595,
-0.015357384,
-0.023749098,
-0.020417094,
-0.0044975197,
0.0044495277,
0.0012109366,
-0.0070890784,
-0.0013377721,
-0.019992024,
0.025901875,
-0.024297576,
0.0027303922,
0.0022658997,
-0.022528734,
-0.0024253011,
0.0013077772,
-0.026642319,
0.002428729,
0.008480841,
-0.0031417506,
-0.015439656,
-0.01666002,
0.03543168,
-0.008535689,
0.005508776,
-0.02461295,
0.016125254,
0.007856947,
-0.008378002,
0.014424971,
0.010256539,
-0.016262373,
-0.011058688,
0.0011809417,
-0.004404964,
-0.02285782,
-0.016070405,
-0.0007241624,
-0.021006707,
-0.023090925,
-0.0029223594,
0.005776159,
-0.015851015,
0.026998831,
-0.024942037,
0.014863754,
-0.0074387332,
0.039984047,
0.016934259,
-0.020458229,
0.012141932,
0.021555185,
-0.0058721425,
-0.031180974,
-0.0016334361,
0.01504201,
-0.004857458,
0.007904939,
-0.009063599,
-0.0016745719,
-0.036802873,
-0.0042164247,
-0.00050991314,
-0.02468151,
0.03493805,
0.015988134,
-0.0031897423,
-0.0023053216,
-0.0053750845,
0.022281919,
0.021568898,
0.015110569,
-0.0051659774,
-0.009289847,
0.012971505,
0.027876396,
-0.010640473,
0.01659146,
-0.033265192,
-0.037241656,
-0.0040827333,
-0.028411161,
0.0020105147,
0.0052825287,
-0.012107652,
-0.009166439,
-0.001957381,
-0.01989604,
-0.040532526,
-0.012608138,
-0.010551346,
0.025819601,
0.04206826,
0.017578721,
-0.012683554,
0.0056424676,
0.020375958,
0.0039490415,
-0.00053348055,
-0.016495476,
0.01054449,
0.0032120245,
0.0007691547,
0.0053065247,
-0.02103413,
-0.006259505,
0.003558251,
0.0048334626,
0.016042981,
-0.015878439,
-0.008885344,
-0.016138965,
-0.01630351,
0.0036645187,
-0.015425944,
0.0069553866,
-0.008480841,
-0.0343073,
0.015521928,
-0.011120392,
0.006002406,
-0.00035393971,
-0.007521005,
0.012793249,
-0.012011669,
0.006879971,
0.0039661815,
0.02468151,
0.00386677,
-0.0156042,
-0.02321433,
0.0036405227,
0.012608138,
0.019813769,
0.017811824,
0.020842165,
-0.015343673,
-0.0076718363,
0.0031537486,
-0.042507045,
-0.012704122,
0.0026824002,
-0.028246617,
0.005824151,
-0.004689487,
-0.03929845,
-0.024407271,
-0.027533596,
0.003623383,
-0.00388391,
0.016001847,
-0.003044053,
-0.017469024,
0.0015717323,
-0.007404453,
0.0196218,
-0.027012542,
0.014767771,
0.003592531,
-0.023584554,
-0.011572886,
0.00015875867,
0.0061703776,
-0.009132159,
0.008905912,
0.03008402,
-0.03129067,
-0.014754059,
0.018182047,
0.008912767,
-0.023954777,
-0.03115355,
0.0006093248,
-0.0066674356,
0.006897111,
-0.0017842675,
-0.0093172705,
-0.025586499,
0.002728678,
-0.019141883,
-0.007006807,
0.0177844,
-0.001969379,
-0.01820947,
0.0136433905,
-0.024283864,
-0.008528833,
-0.00025174284,
-0.0199646,
0.009872604,
-0.036446363,
-0.02608013,
0.0073084696,
0.02292638,
0.01630351,
0.006718856,
0.005292813,
0.017222209,
0.015796166,
0.007822667,
-0.0073153256,
-0.029892052,
0.042315077,
0.022364192,
0.0124573065,
0.017811824,
-0.008172322,
-0.0073221815,
-0.010064571,
-0.010955849,
0.0009375546,
-0.018936204,
-0.000014381479,
0.025984146,
0.01589215,
-0.0025692766,
-0.0010558201,
-0.027670715,
-0.027588444,
-0.034828354,
-0.021623746,
0.023447435,
-0.04217796,
-0.005831007,
0.014932314,
0.0001658289,
0.01360911,
0.0023001796,
0.008809928,
0.017249633,
0.031811725,
0.009166439,
0.010489642,
0.01708509,
0.0261624,
-0.025394533,
0.006365773,
-0.024366135,
-0.007637556,
0.047991827,
-0.0036576628,
-0.024832342,
0.015946997,
0.010304531,
0.012806961,
0.003332004,
0.00011065973,
0.011901973,
0.016180102,
0.021678593,
0.0020945005,
-0.0034571255,
0.035897885,
-0.020430805,
0.0050494256,
0.013478847,
-0.0009881174,
-0.011984245,
-0.006300641,
-0.0021493481,
-0.02459924,
-0.036226973,
-0.031619757,
-0.006945103,
0.030714769,
-0.025586499,
0.014397548,
0.0028846515,
0.0050631375,
-0.018428862,
0.024420984,
0.031372942,
0.005769303,
0.018099774,
-0.004898594,
-0.012189924,
0.035047743,
-0.013766798,
-0.0036370947,
-0.008206602,
-0.022158511,
-0.023186907,
0.020156566,
-0.013965622,
0.038119223,
0.018469997,
-0.02032111,
-0.02573733,
0.011284935,
-0.0405051,
-0.0051042736,
-0.003047481,
0.036309246,
0.014219292,
0.034965474,
0.017935231,
0.02931615,
-0.0024030192,
0.028657977,
-0.0011423768,
-0.026546335,
0.030687345,
-0.0103593785,
0.037927255,
0.009399542,
-0.05043255,
-0.018620828,
0.025792178,
0.0053956523,
0.03260702,
0.0317843,
0.01666002,
0.010928424,
0.018182047,
0.0053750845,
-0.005525916,
0.003938758,
-0.010277106,
-0.04275386,
-0.005045998,
0.020074295,
-0.00017375613,
0.015014585,
0.009893172,
0.006345205,
0.018977338,
-0.01933385,
-0.005947558,
-0.019662937,
0.0017876956,
-0.020554213,
-0.010983272,
-0.0020430805,
-0.03255217,
0.02354342,
0.012141932,
0.0042369924,
0.009570941,
0.0059372745,
0.00090413174,
-0.0121693555,
0.006804555,
0.013492559,
0.008343722,
0.0008351435,
-0.0092212865,
-0.012532722,
-0.003870198,
0.004926018,
-0.032387625,
0.011168383,
0.011188951,
0.031866573,
0.009680637,
0.01885393,
0.019635513,
-0.014630651,
-0.018867644,
-0.0077883876,
-0.00017525586,
-0.01955324,
-0.014740347,
-0.02178829,
-0.020705044,
-0.018264318,
0.0055841915,
-0.027698139,
-0.015275112,
-0.0058892826,
0.20183991,
-0.012354467,
0.014987161,
0.0075758523,
-0.022172224,
-0.008604249,
0.004422104,
0.009070455,
0.008967616,
0.024366135,
0.013945053,
-0.012937225,
-0.01918302,
0.0002358884,
0.0119911,
-0.021980256,
-0.014808906,
-0.027081102,
-0.012738402,
0.0028880795,
-0.024064472,
0.0019025331,
-0.0031794584,
-0.009570941,
0.02313206,
0.0068696872,
0.030495377,
-0.0013197752,
0.01251901,
0.00776782,
-0.01447982,
-0.006348633,
0.013170328,
0.004672347,
0.0003764359,
-0.0055396277,
-0.012052804,
-0.03732393,
0.016783427,
0.003863342,
-0.021486627,
-0.0029720652,
0.01110668,
-0.0037467903,
0.022460174,
0.022240784,
0.0165229,
-0.006804555,
-0.003595959,
-0.020088008,
-0.027547307,
-0.0145895155,
0.018031215,
0.003582247,
-0.021212388,
-0.0040998734,
0.021856848,
0.0054196483,
-0.009358406,
0.0072741895,
0.014301565,
-0.0034914054,
-0.008974471,
0.040340558,
-0.00032565882,
0.033210345,
-0.020088008,
0.009762908,
0.0051042736,
0.003565107,
-0.0070136627,
-0.021226099,
0.01286181,
0.00059132784,
-0.010009724,
-0.02459924,
0.029617812,
0.014068461,
-0.0042438484,
0.021555185,
-0.010270251,
-0.018099774,
0.0009975444,
-0.017126227,
-0.018826507,
-0.0150694335,
0.020718757,
-0.0022487598,
-0.012649274,
0.026889134,
0.009022463,
-0.0020327966,
-0.012107652,
-0.0073084696,
-0.005279101,
-0.011278079,
0.007459301,
0.0060366862,
-0.022185935,
-0.021774577,
-0.022460174,
0.075744815,
-0.003595959,
0.0015340245,
-0.020622773,
0.0059509864,
0.0007190204,
0.026889134,
0.015727608,
-0.0029514972,
0.02136322,
-0.007514149,
0.016138965,
0.0004317122,
0.020759894,
0.04549625,
0.010318243,
-0.028082075,
-0.019320138,
0.00082571653,
0.012251628,
-0.031016432,
0.0013480561,
0.030769616,
0.0039833216,
0.0023310315,
-0.0010078284,
-0.0035753911,
-0.02686171,
-0.013574831,
0.0017517017,
-0.022748126,
-0.0022796118,
-0.015137993,
0.0017585576,
-0.0035479672,
-0.000685169,
-0.014328988,
-0.009296702,
0.014178157,
0.022377903,
-0.01120952,
-0.018812796,
0.009522949,
0.006547456,
-0.030605072,
0.023104636,
-0.008172322,
-0.0048094667,
-0.0045283716,
-0.017386753,
0.001109811,
0.0076238443,
-0.016015558,
0.00441182,
-0.008206602,
-0.0130812,
-0.014260428,
0.030248562,
0.010805016,
-0.005810439,
0.014946026,
0.006016118,
-0.012868665,
0.002183628,
-0.010818729,
-0.1747451,
0.0007035945,
0.010489642,
-0.008480841,
0.03995662,
-0.0033508579,
0.006125814,
0.013094912,
0.010517065,
-0.025984146,
0.03192142,
0.010859865,
-0.006026402,
-0.021171251,
0.004401536,
0.00885792,
-0.014493532,
0.019704072,
0.0045557953,
-0.0014328988,
0.0075689964,
0.002428729,
0.019813769,
-0.0051042736,
-0.012155644,
-0.012018524,
-0.0074935807,
-0.0027063962,
-0.0055362,
-0.027382765,
-0.013177184,
0.012347612,
0.016468052,
0.02038967,
-0.022089953,
-0.00776782,
0.009721773,
0.0022658997,
-0.005011718,
0.017674703,
0.014466108,
0.00885792,
-0.025984146,
-0.0020910725,
-0.004178717,
0.052077986,
-0.008391714,
-0.019114459,
0.013307448,
0.01086672,
0.008940192,
0.004151293,
0.004055309,
0.022528734,
0.014233004,
-0.0066742916,
-0.0021819142,
-0.015014585,
-0.0057487353,
0.03241505,
-0.017181074,
-0.009550373,
-0.011195808,
-0.013506271,
-0.020129142,
-0.007143926,
0.0057110274,
0.010386802,
-0.021610033,
-0.012388747,
-0.03115355,
0.005004862,
0.015316249,
-0.0037844982,
0.02389993,
0.014987161,
-0.0068696872,
-0.00040707353,
0.013670814,
-0.017414177,
-0.016577749,
-0.008563113,
-0.008042059,
0.007932363,
-0.01885393,
0.02241904,
0.012944081,
-0.0094612455,
0.017249633,
-0.025517939,
0.0104553625,
-0.029727507,
0.02277555,
-0.016989106,
-0.015563063,
0.021993969,
-0.0104553625,
-0.018236894,
0.0050254297,
-0.0040038894,
0.02468151,
-0.01885393,
0.0004413534,
0.0042061405,
0.02059535,
-0.0073084696,
0.005426504,
-0.0059921225,
0.024325,
0.014534667,
-0.0019179591,
-0.0060058343,
0.017277058,
0.033731397,
-0.006585164,
0.021939121,
0.007719828,
0.0045557953,
-0.0061223856,
-0.02762958,
0.08435592,
-0.015425944,
-0.005807011,
0.008000923,
0.019676648,
-0.0003556537,
-0.12516268,
-0.012848098,
0.017935231,
-0.004593503,
0.0058344346,
0.005333949,
0.0025641348,
0.0042747003,
-0.025970433,
0.033758823,
-0.02939842,
-0.0138833495,
-0.011511182,
-0.010146843,
0.035486527,
-0.015110569,
-0.0040998734,
-0.033703975,
0.010722745,
0.02819177,
0.0042369924,
-0.008638529,
-0.0005977553,
-0.0057110274,
-0.015425944,
-0.021993969,
-0.032524746,
0.0064514726,
0.011168383,
0.016180102,
0.001095242,
-0.0075347167,
-0.0021459202,
-0.030330835,
-0.023049789,
0.0007575853,
-0.03628182,
-0.035843037,
0.018236894,
-0.0064549004,
-0.0143427,
0.026066417,
0.029700084,
-0.003035483,
0.016783427,
-0.011881405,
-0.032716714,
0.02144549,
0.02178829,
-0.0104553625,
-0.039764658,
-0.014301565,
-0.030879311,
0.011353495,
0.032223083,
-0.02369425,
-0.004435816,
-0.0054607843,
-0.026738303,
0.008460273,
-0.020019447,
-0.0001388335,
-0.0047683306,
0.008748224,
0.0050254297,
-0.023515996,
-0.027382765,
-0.00609839,
0.017880384,
-0.013519983,
-0.013478847,
0.0030886168,
-0.0048197503,
-0.018099774,
-0.0031451785,
0.005498492,
-0.0135953985,
-0.011476902,
0.014054749,
0.0024270152,
-0.014424971,
-0.0145895155,
0.015755031,
-0.018991051,
0.017839247,
-0.0012820674,
0.002461295,
0.0003995748,
0.015782455,
-0.008090051,
-0.02347486,
0.015631624,
-0.02502431,
0.006125814,
-0.0005968983,
0.005800155,
-0.0056698914,
-0.03241505,
0.009111591,
0.032003693,
-0.025504228,
-0.008453418,
-0.055560824,
0.0011655157,
0.010133131,
-0.007164494,
-0.005985266,
-0.016550325,
0.026683455,
0.0014363268,
0.01374623,
-0.008837352,
-0.015768742,
0.007692404,
-0.046209272,
-0.014178157,
-0.014795194,
-0.0075347167,
0.024091898,
-0.0014440397,
0.009145871,
0.037159387,
0.011614022,
-0.019210443,
0.017907808,
0.022131087,
0.014534667,
0.00012565717,
-0.023858793,
0.020622773,
0.0087893605,
0.0066982876,
0.019237867,
-0.012066516,
-0.01567276,
-0.0073838853,
-0.0064788964,
-0.0047751865,
-0.0029240735,
0.033621702,
0.0051214136,
0.02609384,
-0.014534667,
-0.040532526,
0.0005313381,
-0.005841291,
-0.026244672,
0.0110792555,
-0.031729452,
0.017825535,
-0.007404453,
-0.024859766,
0.050597098,
0.017249633,
0.0034399854,
-0.029288726,
-0.019635513,
0.014109597,
0.016961683,
-0.0018905351,
-0.008611104,
-0.0050802776,
0.035815615,
-0.011764853,
0.012834385,
-0.013924485,
0.014658075,
-0.016975394,
-0.020979283,
0.007143926,
0.0057418793,
-0.01751016,
-0.016701156,
0.021802,
-0.02503802,
0.024777494,
0.0048231785,
-0.0069245347,
0.011182096,
0.027355341,
-0.0030646208,
0.0031726025,
0.021102691,
0.00030316264,
-0.027931243,
0.009488669,
0.00812433,
-0.00041907147,
-0.00550192,
0.04239735,
-0.0052996688,
0.03030341,
-0.009570941,
0.014575803,
-0.015508216,
0.018716812,
0.012992073,
0.01856598,
-0.010071428,
-0.016851988,
-0.0032685862,
0.020279974,
-0.006043542,
-0.011332927,
-0.0005998978,
-0.012285908,
-0.025476804,
0.010078283,
-0.030358259,
-0.03277156,
-0.015137993,
0.032195657,
0.020444518,
-0.00390105,
-0.018195758,
0.0065817363,
-0.0030971868,
0.0022624717,
0.00048848824,
-0.014630651,
-0.008007779,
0.035897885,
0.0075072926,
0.009166439,
-0.0050905617,
0.0110792555,
0.038996786,
0.015974423,
0.016440628,
-0.034499265,
0.023749098,
-0.0036885147,
0.017880384,
0.0012914944,
-0.008679665,
0.0045043756,
0.0017217067,
-0.019758921,
0.03192142,
0.02284411,
0.0122173475,
0.062745884,
0.010770737,
-0.0030183431,
-0.007987211,
-0.0099823,
-0.007870659,
-0.00034536974,
0.008350578,
0.0004962012,
-0.026354369,
0.009783477,
-0.0070410864,
0.02059535,
-0.020005735,
0.00773354,
0.016001847,
-0.0010583912,
0.009207575,
-0.004401536,
-0.017043954,
0.014726634,
-0.019992024,
0.018661965,
0.02502431,
0.0011817988,
-0.030111443,
0.008768792,
-0.002480149,
0.00928299,
-0.010921569,
0.00384963,
0.01146319,
-0.04673033,
-0.006664008,
0.0011860837,
0.0019436689,
-0.011682582,
-0.018524844,
0.017894095,
-0.00885792,
0.016865699,
0.018689388,
-0.024695223,
-0.009879461,
-0.019937176,
-0.050459977,
-0.0054299324,
-0.01700282,
-0.008604249
] |
Adult blood cell production or definitive hematopoiesis requires the transcription factor c-Myb. The closely related KAT3 histone acetyltransferases CBP (CREBBP) and p300 (EP300) bind c-Myb through their KIX domains and mice homozygous for a p300 KIX domain mutation exhibit multiple blood defects. Perplexingly, mice homozygous for the same KIX domain mutation in CBP have normal blood. Here we test the hypothesis that the CBP KIX domain contributes subordinately to hematopoiesis via a genetic interaction with c-Myb. | [
-0.025571082,
-0.022737242,
0.012745627,
-0.033952862,
-0.038636014,
0.015552859,
-0.026289519,
-0.00091966754,
-0.00046814902,
-0.0019474335,
0.000010368088,
-0.0066887937,
0.019677227,
-0.0045534354,
-0.021752715,
-0.015725816,
0.018533047,
-0.0015374912,
-0.004576718,
0.0011874188,
-0.027486917,
0.01733565,
-0.003904845,
-0.025078818,
-0.011381925,
0.0058838767,
0.0063062916,
-0.027433699,
-0.009246567,
-0.01857296,
0.02360203,
0.018839048,
-0.010929575,
-0.0012830443,
-0.016045121,
0.009525959,
-0.008508172,
-0.023628637,
0.019145051,
0.004180912,
0.022710633,
0.035283305,
-0.007956039,
0.0021253799,
-0.01154823,
-0.011295446,
0.00600029,
-0.009752135,
-0.02086132,
0.020036446,
-0.00021536519,
-0.0066887937,
-0.0010177876,
-0.0029835147,
-0.012931889,
-0.009984962,
0.026103258,
0.01673695,
-0.0041177156,
-0.0055678966,
0.006063486,
-0.018346785,
0.0065524234,
-0.008874044,
-0.004836154,
0.007803038,
0.015925381,
0.0021453365,
-0.005458135,
0.009499351,
0.027247438,
0.01404946,
-0.01631121,
-0.004247434,
0.017974261,
0.010290964,
-0.03515026,
-0.00619653,
-0.021273756,
0.015153727,
0.015473032,
0.004091107,
-0.024626467,
0.029269708,
0.01275228,
-0.0133509785,
-0.003638757,
0.006412727,
0.015233553,
0.013304413,
0.01721591,
0.015326683,
0.03312799,
0.02040897,
-0.013304413,
-0.003801736,
0.010769922,
0.04185568,
-0.0010335866,
-0.026222998,
-0.014568332,
-0.00086146075,
-0.012526105,
-0.02052871,
-0.032037027,
-0.00036711866,
0.0005055677,
0.00028188725,
0.03576226,
-0.0035023866,
-0.02360203,
0.016204774,
0.0025078817,
-0.044702828,
0.029429361,
-0.018892266,
-0.004094433,
0.00651251,
-0.025943605,
-0.0004382141,
0.02233811,
0.0500512,
-0.00035443789,
-0.017947653,
0.01139523,
0.031079108,
-0.020196099,
-0.019158354,
0.0029885038,
-0.023123069,
0.020568622,
-0.0053217653,
0.0053517,
0.015127118,
-0.02004975,
-0.0077099074,
-0.021273756,
0.015393206,
-0.004739697,
-0.038369928,
-0.0020522056,
0.031664502,
-0.009812005,
0.0014410343,
0.005714245,
0.035230085,
0.011654666,
-0.016577298,
-0.0058905287,
0.004180912,
0.005391613,
0.003997976,
0.04922633,
-0.0075968197,
0.009998267,
0.016204774,
-0.0056211143,
0.024386989,
0.0075502545,
-0.008860739,
-0.0030367323,
0.006991469,
0.008894,
0.0052984823,
0.004254086,
0.025278384,
0.0022368045,
-0.0033593643,
0.014115982,
-0.02357542,
0.016484167,
0.0066854674,
-0.0328619,
0.013969634,
-0.025664212,
0.017615043,
-0.0014601593,
0.023136374,
-0.045048743,
-0.016776865,
-0.00940622,
0.016178166,
0.026156476,
0.004410413,
-0.009825309,
-0.010091397,
0.017827913,
-0.05053016,
0.0036354307,
-0.009898483,
0.011368621,
0.0016314536,
0.010730009,
-0.024200726,
-0.64286923,
-0.0069515556,
0.013863198,
-0.02288359,
0.0061466387,
0.03693305,
0.024493424,
-0.009452785,
-0.01103601,
0.026395956,
0.0049060024,
0.022684025,
0.016816778,
-0.030413888,
-0.020981058,
-0.032356333,
-0.0063728136,
-0.027939267,
0.024998993,
0.006831816,
-0.0006440167,
-0.025238471,
-0.016284602,
0.02595691,
-0.010902966,
0.012113668,
0.034777734,
-0.0021386843,
0.0030467105,
0.029988147,
-0.0076433853,
0.04076472,
0.00042303876,
0.020981058,
0.05053016,
0.009878526,
0.009186697,
0.012991759,
-0.0009895157,
0.035442956,
0.007543602,
0.0066887937,
0.017029649,
0.005288504,
-0.009153436,
0.012951846,
-0.011601448,
0.022205066,
0.007443819,
0.006156617,
-0.023468984,
-0.008401737,
-0.017109474,
-0.009552568,
-0.010424008,
0.018173829,
0.017069561,
-0.020369057,
-0.00022347255,
-0.0070646433,
-0.023016633,
0.009259871,
-0.025531169,
-0.013849894,
0.0034757778,
0.000020970041,
-0.01571251,
-0.00574418,
0.011268837,
-0.003572235,
-0.0006702098,
0.006958208,
-0.025358211,
0.014328852,
0.01983688,
0.021154016,
0.0073972535,
-0.002607665,
-0.008827478,
0.0038582797,
-0.006662185,
-0.0010685107,
0.0064592925,
0.009379611,
0.036640354,
0.0031198848,
-0.013889807,
0.025371516,
-0.005504701,
-0.007975996,
-0.013410849,
-0.0066023148,
-0.0075569064,
-0.016896604,
-0.03270225,
0.00714447,
0.018280264,
0.007516993,
0.009758787,
-0.017468695,
-0.0067187287,
-0.0055279834,
-0.0047563277,
-0.012546062,
0.0070180777,
0.00826204,
-0.019437747,
-0.011495013,
0.048907023,
-0.030999282,
0.011228925,
-0.007570211,
-0.009639047,
-0.021034276,
0.0028521335,
-0.016803473,
0.016391037,
0.0018409982,
-0.00009474197,
-0.0145816365,
0.009625743,
0.012991759,
0.012532757,
-0.028604487,
0.019584095,
0.008641216,
-0.0062065087,
0.0066222716,
-0.011435143,
-0.00022970901,
0.002549458,
0.0018709331,
0.008647868,
-0.031824157,
0.03536313,
-0.008887348,
0.030520324,
-0.0010103039,
0.01754852,
-0.028125528,
-0.032116853,
-0.012040494,
-0.021167321,
0.023216201,
0.008667825,
-0.006113378,
-0.009712221,
-0.0016489157,
0.00973883,
0.0032412875,
0.0018809114,
-0.010783226,
-0.00078205,
0.006569054,
0.010543747,
-0.023681855,
-0.0055213314,
0.0023332613,
0.0038083883,
-0.02514534,
-0.0017545194,
0.018000871,
0.009898483,
0.01239306,
0.0023814898,
-0.007822995,
-0.0084882155,
0.012532757,
-0.0028404922,
-0.020581927,
0.012073754,
-0.017029649,
-0.028897185,
-0.024959078,
-0.004254086,
0.003861606,
-0.0010577008,
-0.0042673904,
-0.019610705,
-0.008089083,
-0.0079161255,
-0.0011425165,
-0.010284311,
-0.015140422,
0.038210273,
0.011195663,
0.020728275,
0.0052452646,
0.0015291759,
0.038582798,
-0.015140422,
0.01082314,
-0.026262911,
0.0062331175,
0.014448592,
-0.032356333,
0.009466089,
0.029189881,
-0.009106871,
0.03538974,
0.0135705015,
-0.0033560381,
0.005374983,
-0.018639483,
0.01154823,
-0.026342737,
-0.02309646,
-0.02676848,
0.0025411427,
-0.015260162,
-0.0019424442,
0.009752135,
-0.0071112085,
0.0063994224,
0.016510777,
-0.001194071,
-0.017681565,
-0.008548086,
-0.014089373,
-0.008894,
0.000099107485,
0.002190239,
0.020422274,
0.002446349,
0.0061799,
0.0011433479,
0.02152654,
0.014395375,
0.014781203,
0.0054082437,
-0.015260162,
0.0094394805,
-0.0061699213,
-0.011268837,
-0.0005467282,
-0.00810904,
0.019158354,
-0.0029535796,
0.020794798,
0.00934635,
0.014262331,
-0.006635576,
-0.0015058932,
-0.012373104,
0.009479394,
-0.020901233,
0.021260452,
-0.000011966176,
-0.020542014,
0.013969634,
-0.0037917576,
0.023868117,
-0.014368766,
-0.013743458,
0.000492679,
-0.0028488075,
-0.0021736084,
0.017295737,
0.022630807,
0.02378829,
0.023162983,
-0.016204774,
-0.00541157,
-0.026276216,
0.008295301,
0.022444544,
-0.001935792,
-0.010470573,
-0.008275345,
-0.0026242954,
-0.041562986,
0.00012410522,
0.012938541,
-0.026329434,
0.016005209,
0.0039381064,
0.018280264,
0.0028105571,
0.007669994,
0.0055113533,
-0.010630226,
-0.035203476,
0.027407091,
0.032329723,
-0.017748088,
-0.006149965,
0.0026375998,
-0.033447295,
-0.0024629794,
0.027619962,
0.010324225,
0.0037651488,
0.007344036,
0.000040458926,
-0.008687781,
-0.007184383,
0.025278384,
-0.008907304,
0.014328852,
0.012938541,
-0.01257267,
-0.0043073036,
-0.011840927,
-0.0014019525,
0.023202896,
-0.006662185,
-0.017734783,
-0.023535507,
-0.014980769,
-0.005571223,
-0.0028853945,
-0.025943605,
-0.01275228,
-0.009845265,
-0.003608822,
-0.0064925533,
-0.011009402,
0.016324515,
0.016377732,
0.015818946,
-0.028019093,
-0.018293567,
-0.014036155,
-0.004709762,
0.025118731,
0.019983228,
-0.03472452,
0.012978455,
-0.021752715,
-0.007497037,
-0.026781783,
-0.016577298,
0.034298778,
0.0014086047,
0.003031743,
0.017814608,
-0.001227332,
-0.000008516643,
-0.009605786,
0.015805643,
-0.015047291,
-0.029562406,
-0.01019118,
-0.000031026306,
-0.008102387,
0.011588143,
0.01667043,
0.046086486,
0.037305575,
0.0016314536,
-0.0031099066,
0.02348229,
0.005514679,
-0.002802242,
0.0007005605,
0.011867536,
0.0030467105,
0.01585886,
0.016244689,
-0.021287061,
0.01766826,
0.022777155,
-0.010557052,
0.0029702103,
0.015552859,
0.0154597275,
0.01133536,
0.0037119312,
0.0028554597,
-0.013690241,
0.009971658,
-0.019783663,
-0.009845265,
-0.021060886,
0.025916995,
-0.015366597,
-0.03169111,
-0.011342012,
0.0076566897,
-0.0084150415,
0.005674332,
-0.015233553,
0.005128851,
-0.013311065,
-0.0031531458,
-0.03967376,
0.011375273,
0.003638757,
-0.013543893,
-0.012745627,
-0.01652408,
-0.024307162,
-0.03326103,
-0.0047862628,
0.011268837,
-0.011801015,
-0.01950427,
0.008521477,
0.025371516,
0.024466814,
0.020635145,
-0.017841218,
-0.014648158,
0.006865077,
-0.03150485,
-0.005165438,
-0.0007832973,
-0.017269127,
0.0056876363,
-0.0027041219,
0.018000871,
-0.026568912,
0.0047596535,
0.010577008,
0.004636588,
0.009984962,
0.0010543747,
-0.03448504,
-0.011721187,
0.006735359,
0.005990312,
0.017734783,
-0.000105863626,
-0.00047895886,
-0.0077830814,
-0.016723648,
-0.022271587,
-0.023628637,
0.0037518444,
0.0017279106,
-0.01172784,
0.016976431,
-0.029136663,
-0.008002604,
0.013676937,
-0.016617212,
0.019743748,
-0.0051388294,
0.02686161,
0.02602343,
0.0031381785,
0.025211863,
0.010224441,
-0.006472597,
-0.011874189,
-0.024559947,
0.015286771,
0.008880695,
-0.0259303,
0.025344906,
-0.0067619677,
-0.017521912,
-0.0123598,
0.010217789,
-0.026675347,
0.043212734,
-0.0024064358,
-0.026529,
-0.02345568,
-0.00038582797,
0.012333191,
0.00753695,
0.026249606,
-0.00011838849,
-0.019770358,
0.011781057,
0.013823285,
-0.014914247,
0.010543747,
-0.03711931,
-0.0009712221,
0.032090243,
0.000887238,
-0.022524372,
0.005518005,
-0.009273176,
-0.012306582,
-0.022271587,
-0.02550456,
-0.04688475,
0.011807666,
-0.00023282722,
0.036161393,
0.032941725,
0.0328619,
0.028365009,
0.0026691977,
0.009765439,
0.01212032,
0.018147219,
-0.0034391908,
0.031558067,
-0.027726397,
0.0044004344,
-0.016923213,
-0.00822878,
0.014927551,
-0.015951991,
0.03142502,
0.035709046,
-0.018719308,
-0.027992485,
0.020448882,
-0.026529,
-0.02243124,
0.009925092,
-0.013291108,
0.005518005,
-0.051567905,
-0.008355171,
0.006898338,
-0.0012738975,
0.008428345,
-0.0024363706,
0.044010997,
-0.023162983,
0.025424734,
-0.012659149,
0.008568042,
-0.0070114257,
0.0020488796,
0.0061433124,
0.0020455534,
0.025012296,
0.005221982,
0.003768475,
-0.0027174263,
-0.0073107746,
0.0008069958,
0.0045833704,
-0.014568332,
-0.0111091845,
-0.009027044,
0.0032296462,
-0.010390746,
-0.021499932,
-0.015353292,
-0.029615624,
-0.002767318,
0.004160955,
-0.034139123,
0.006662185,
0.01347737,
-0.018320177,
0.03307477,
-0.020848015,
0.0310525,
-0.023282722,
0.027460309,
0.028152138,
0.0061466387,
-0.0027523504,
-0.020063054,
-0.013031673,
0.01631121,
0.032782074,
0.03536313,
-0.021287061,
-0.013756763,
-0.0008506509,
0.0140095465,
-0.026489086,
-0.013730154,
0.0022916852,
-0.035895307,
0.011368621,
-0.00574418,
0.0014368766,
-0.009831961,
-0.01859957,
-0.007031382,
0.0049825027,
0.0030550258,
-0.008647868,
-0.02809892,
0.017415477,
-0.0067120763,
-0.0042707166,
0.013809981,
-0.009399568,
-0.00413102,
-0.004869415,
-0.024613164,
0.0069715125,
-0.0061100516,
0.037092704,
0.00631627,
0.01091627,
0.013464066,
0.0014418657,
0.0038882147,
-0.0030849606,
0.00167303,
0.04127029,
0.013237891,
-0.000533008,
0.0018243676,
0.0052918303,
0.007962691,
0.004084455,
-0.0084150415,
-0.018799135,
-0.024546642,
0.001337925,
0.024174118,
-0.0008797543,
-0.007703255,
0.013982938,
-0.025344906,
-0.010929575,
-0.04193551,
-0.012938541,
0.0030849606,
-0.04712423,
-0.013124803,
0.02071497,
0.012546062,
0.0048494586,
-0.004613305,
0.004965872,
0.0009703906,
0.010769922,
-0.015366597,
0.02921649,
0.012326539,
0.0051720906,
-0.026449174,
0.007936082,
-0.013956329,
-0.007975996,
-0.0036287785,
-0.015805643,
-0.0006677152,
0.0061399867,
-0.002416414,
0.025571082,
0.021819238,
-0.012186842,
0.010949532,
0.00040432942,
0.019783663,
-0.0019424442,
0.004520174,
0.0029169924,
-0.021034276,
-0.013650328,
-0.003608822,
0.0054082437,
-0.022178456,
-0.008095736,
-0.0018160524,
0.020781493,
-0.013284456,
-0.012858715,
0.010324225,
0.010410703,
-0.0015009041,
0.0019191615,
-0.012492844,
-0.018825743,
-0.0145949405,
0.01148836,
0.0061699213,
0.0010859726,
-0.029110055,
0.020967755,
-0.027619962,
0.013603762,
-0.017415477,
0.018160524,
-0.016603908,
-0.048907023,
-0.032090243,
0.03126537,
-0.021779323,
0.03759827,
0.012592627,
-0.0081955185,
-0.043771517,
-0.0070446865,
-0.038024012,
-0.02436038,
0.01769487,
0.021792628,
0.0033726688,
-0.0015557847,
0.0053284173,
0.0132778045,
0.0034325386,
0.011954015,
-0.00009448212,
-0.0057574846,
0.021912368,
0.010404051,
0.027806222,
-0.00027523504,
-0.017987566,
-0.012552714,
0.020089664,
0.0073041227,
0.006046856,
0.03986002,
-0.009359654,
0.015246857,
0.0052984823,
0.027380481,
0.008035866,
0.019437747,
0.012020537,
-0.023282722,
-0.014688072,
0.0018276937,
-0.000018774293,
-0.010437312,
-0.009506003,
0.004985829,
0.007031382,
-0.010277659,
-0.0030966022,
-0.038236883,
0.012685758,
-0.012705714,
0.017402172,
0.021114103,
0.0000562839,
0.015140422,
0.022564285,
-0.01428894,
-0.017255824,
0.0021303692,
-0.017202606,
-0.028258573,
-0.009945049,
-0.0105969645,
-0.0026459151,
-0.0031032544,
-0.016244689,
-0.027619962,
-0.016191471,
-0.013637023,
-0.024041073,
-0.0134241525,
0.012007233,
-0.010397399,
-0.0145816365,
0.004679827,
-0.0010909619,
-0.013224587,
-0.018346785,
0.0061167036,
-0.016803473,
-0.004570066,
-0.0026359367,
-0.005508027,
-0.018865658,
-0.013078238,
-0.0002546548,
0.009525959,
0.008787565,
0.030919455,
0.18658109,
-0.011687927,
0.0044603045,
0.006159943,
-0.009792048,
-0.0373854,
0.012772236,
0.008800869,
0.019238181,
0.0023981205,
0.016697038,
0.018972093,
-0.0130582815,
-0.006186552,
0.01206045,
-0.022417936,
-0.018732613,
0.005996964,
-0.026968045,
-0.027300656,
0.0048461324,
-0.002418077,
0.000587473,
0.005195373,
0.03719914,
0.011887493,
-0.011887493,
0.007516993,
0.0079028215,
0.0057208976,
-0.026914828,
0.0150206825,
0.0010053146,
-0.005391613,
-0.0062031825,
0.003701953,
-0.0028238615,
-0.019730445,
0.007230948,
-0.0061665955,
-0.016031817,
0.007822995,
-0.013577153,
0.015233553,
0.004746349,
0.020488795,
0.008481563,
-0.014568332,
0.0061665955,
0.01736226,
-0.03443182,
-0.014714681,
0.018612873,
0.022617502,
-0.0055013746,
-0.019344617,
0.015433119,
0.00006792526,
-0.012639192,
0.010497182,
-0.0036653657,
0.0072376006,
-0.044702828,
0.01981027,
-0.0052751997,
0.026183084,
-0.02173941,
0.014555028,
0.036587134,
-0.030254235,
-0.017282432,
-0.009486047,
-0.0020821407,
-0.0021802606,
0.01037079,
-0.026848305,
0.0145949405,
0.03711931,
0.023362549,
0.008361824,
0.018213741,
-0.0016223069,
-0.020555317,
-0.0061399867,
-0.0022085325,
-0.019424442,
0.0028221987,
0.0033560381,
-0.02183254,
-0.033846427,
0.019251486,
-0.010284311,
0.0030184386,
-0.0033294293,
0.0034425168,
-0.003904845,
-0.0058206804,
0.008980479,
-0.006389444,
0.009020392,
-0.041536376,
0.064446576,
0.0008290312,
0.023761682,
-0.0124728875,
-0.008754304,
-0.014767898,
0.0021802606,
-0.014235722,
-0.0035323217,
0.013577153,
-0.0036587135,
0.011914101,
-0.00670875,
0.0002544469,
0.014342157,
-0.004663197,
-0.027593352,
0.021380192,
0.007723212,
-0.009792048,
-0.024799425,
0.009013739,
0.031212153,
-0.01609834,
0.012333191,
-0.021579757,
-0.025344906,
-0.011781057,
-0.042707164,
-0.008474911,
-0.0027540135,
0.013623719,
-0.0029552428,
0.0032296462,
0.002416414,
-0.000241974,
-0.019823575,
-0.025198558,
0.029881712,
-0.009652352,
-0.020542014,
0.008135648,
0.008175562,
0.002767318,
-0.030440496,
0.019198269,
0.019703835,
-0.02767318,
-0.0012364789,
-0.037704706,
-0.014914247,
-0.002903688,
-0.0066289236,
0.013982938,
-0.025371516,
0.0041077374,
-0.027407091,
0.012246712,
0.009333045,
-0.029775277,
0.00928648,
0.006479249,
-0.014022851,
-0.0010626899,
-0.01857296,
-0.1676356,
0.00020455534,
0.004323934,
-0.010131311,
0.005953725,
0.024466814,
-0.01097614,
-0.009120175,
0.008295301,
-0.012186842,
0.026901523,
0.006931599,
-0.045394655,
-0.014674768,
0.011302099,
-0.013271152,
-0.02333594,
0.054760963,
0.0143022435,
0.013437457,
0.01826696,
-0.012140277,
0.026582217,
0.0006947398,
0.007091252,
0.019331312,
0.014674768,
-0.028231964,
-0.0016855028,
-0.021792628,
-0.009512655,
-0.0023981205,
0.018426612,
0.012373104,
0.023588724,
-0.0028870576,
-0.008940565,
0.0031714395,
-0.0040046284,
0.0066522066,
0.028019093,
0.006871729,
-0.019065224,
0.009565873,
-0.00038520433,
0.05981664,
-0.0046498924,
0.013849894,
0.037039485,
-0.005308461,
0.008128996,
0.0025511212,
0.013577153,
0.019983228,
0.016031817,
0.005724224,
0.012033842,
0.017960958,
-0.0060501816,
0.022511067,
-0.012379756,
-0.0068584247,
0.040684894,
-0.01947766,
-0.013244543,
-0.022218369,
0.012792193,
0.045048743,
-0.021992195,
-0.0057574846,
-0.01450181,
-0.002326609,
0.01281215,
-0.015805643,
0.016803473,
0.017136084,
-0.0035522783,
-0.001450181,
0.004826176,
0.015499641,
-0.037465226,
0.017721478,
-0.037092704,
-0.025065513,
-0.0259303,
0.010457269,
0.010989445,
-0.0030716562,
0.0079892995,
-0.0199034,
-0.0045002177,
-0.018107306,
-0.0061266823,
-0.013217934,
0.032941725,
0.021353582,
-0.0398068,
-0.03083963,
-0.0020305861,
0.012758932,
0.039141584,
-0.025092123,
-0.010756617,
-0.007570211,
0.052233126,
0.020023141,
0.0035057128,
0.018972093,
0.048587717,
-0.0053882874,
0.004360521,
0.005564571,
0.019969923,
0.018878961,
0.011129142,
0.011914101,
-0.009339698,
0.009279828,
-0.00024467646,
-0.016191471,
0.07775099,
0.003638757,
-0.014914247,
0.021593062,
-0.017082866,
0.0036287785,
-0.1419847,
-0.01290528,
-0.013996243,
0.0030201017,
0.001418583,
0.0011973971,
0.009180045,
0.036108177,
0.012446278,
0.014994074,
-0.029269708,
-0.014249026,
-0.009459438,
-0.012279973,
0.0018276937,
0.027912658,
0.02155315,
-0.008528128,
-0.009153436,
0.031957198,
0.0013088216,
0.0071112085,
-0.0024613163,
-0.011495013,
0.016138254,
0.005764137,
-0.049093284,
0.00919335,
0.02297672,
0.0148743335,
0.003991324,
-0.03352712,
0.021672888,
0.00072675355,
-0.013943025,
-0.0060235728,
0.011295446,
-0.026795087,
0.04345221,
-0.016776865,
-0.015765728,
0.008987131,
0.0003943511,
-0.028524661,
0.02366855,
0.0018094002,
-0.011767753,
0.012080407,
0.021899063,
-0.009452785,
-0.03142502,
-0.013756763,
-0.02900362,
-0.012220103,
0.019703835,
-0.027593352,
0.0088540865,
0.022923503,
-0.027992485,
-0.012492844,
0.019823575,
-0.0107433135,
-0.011075924,
-0.005604484,
0.03373999,
-0.025344906,
-0.01757513,
-0.028657705,
0.02107419,
-0.03397947,
-0.013590458,
0.026489086,
-0.008800869,
0.0013395881,
-0.025890388,
0.0020771516,
-0.027832832,
-0.012080407,
-0.003065004,
-0.015180335,
-0.014115982,
-0.009359654,
0.025411429,
-0.017947653,
0.010091397,
0.007882864,
0.0054913964,
0.0008198844,
0.0050822855,
-0.0025694147,
-0.012326539,
0.0410042,
-0.00010705895,
-0.014209113,
-0.00747708,
0.004027911,
0.018745918,
-0.017588433,
0.01383659,
0.03650731,
-0.015765728,
-0.02285698,
-0.051301815,
-0.00470311,
0.017654955,
0.0014684746,
0.026342737,
-0.017282432,
0.022777155,
-0.0016954811,
-0.021473322,
0.013357631,
0.0023133047,
0.0033244402,
-0.03083963,
-0.019211572,
-0.0064260312,
0.004150977,
0.03169111,
-0.008820826,
0.031850763,
0.022045413,
0.012446278,
-0.009466089,
0.015193639,
-0.0026841653,
-0.025185253,
-0.01287202,
-0.017282432,
0.016843386,
-0.0035921915,
-0.0016472526,
0.0027024588,
-0.045900226,
0.007157774,
-0.0002107918,
0.009186697,
-0.011461752,
-0.027127698,
0.013996243,
0.018559655,
0.02402777,
-0.0061699213,
-0.026103258,
0.002449675,
-0.011029358,
-0.011501665,
0.007057991,
-0.0428136,
0.01037079,
0.002318294,
-0.011967319,
0.046059877,
0.0001814805,
0.026529,
-0.029402753,
-0.009140132,
-0.004064498,
-0.0034192342,
-0.0018459873,
0.007836299,
-0.023894725,
0.010863053,
0.013876502,
0.01769487,
-0.009466089,
-0.010670139,
-0.006386118,
-0.022896895,
-0.009033697,
0.0032279831,
-0.029775277,
-0.025451342,
0.0074903844,
-0.0007666668,
0.006292987,
0.015206944,
0.0008672814,
-0.008468259,
0.00895387,
-0.0048494586,
0.025970213,
0.0036520613,
-0.013437457,
-0.0186927,
0.001993999,
0.026382651,
-0.016510777,
-0.018519742,
0.019584095,
-0.010497182,
0.011634709,
0.0065158363,
0.008754304,
0.015938686,
0.016869996,
0.02764657,
0.022364719,
-0.018413307,
0.0059104855,
0.007230948,
0.038662624,
-0.0091467835,
-0.0151670305,
-0.005185395,
-0.03123876,
-0.00747708,
0.03711931,
-0.0054947226,
-0.031584676,
-0.016936518,
0.0067919027,
0.012439626,
0.002868764,
-0.0044203913,
0.005504701,
-0.0032496029,
0.0054348526,
-0.0052352864,
0.014036155,
-0.003159798,
0.050343897,
0.007191035,
0.0026908175,
-0.018533047,
0.0010710052,
0.03693305,
-0.0042407815,
0.034990605,
-0.016750256,
0.017561825,
-0.019357922,
0.023162983,
0.010483878,
-0.017162692,
0.01652408,
-0.009113523,
-0.004407087,
0.02436038,
0.0238149,
-0.0007146964,
0.09068288,
0.0128387585,
-0.017521912,
-0.007669994,
-0.0059503987,
0.022298196,
0.026835,
0.010437312,
-0.0022667393,
-0.015579468,
0.016284602,
-0.033926252,
0.030387279,
-0.029509189,
-0.027726397,
0.025251776,
-0.010237746,
0.008614607,
0.010131311,
-0.017481998,
-0.0016539048,
-0.031105718,
0.007936082,
0.02664874,
-0.028471444,
-0.008913957,
0.017681565,
0.0073706447,
0.0021353583,
-0.018719308,
-0.001224006,
-0.010264355,
-0.031132326,
0.000114854505,
0.005092264,
-0.0053783087,
-0.004350543,
-0.0039447583,
0.01631121,
0.032143462,
-0.0029918298,
-0.017960958,
-0.0027041219,
-0.012665801,
0.0032096896,
-0.017601738,
-0.006958208,
-0.0014135939,
-0.005218656
] |
CONTEXT Clinicians and trialists have difficulty with identifying which patients are highest risk for cardiovascular events. Prior ischemic events, polyvascular disease, and diabetes mellitus have all been identified as predictors of ischemic events, but their comparative contributions to future risk remain unclear. OBJECTIVE To categorize the risk of cardiovascular events in stable outpatients with various initial manifestations of atherothrombosis using simple clinical descriptors. DESIGN, SETTING, AND PATIENTS Outpatients with coronary artery disease, cerebrovascular disease, or peripheral arterial disease or with multiple risk factors for atherothrombosis were enrolled in the global Reduction of A | [
-0.025208337,
-0.012859613,
0.01626778,
-0.033584226,
-0.017343335,
0.03522445,
0.0015377086,
0.019104557,
-0.024294114,
-0.00084279873,
-0.00042476048,
0.009438002,
-0.0070314454,
0.011979002,
-0.0004390452,
0.025329337,
0.04272645,
0.0018670975,
0.02074478,
-0.023232004,
-0.046706006,
0.01696689,
-0.019615447,
-0.00096295844,
-0.008382612,
0.00028800525,
0.011474835,
-0.03664956,
-0.0046282504,
-0.019521335,
0.008369167,
0.0019343197,
-0.01732989,
-0.024307558,
-0.00009783985,
0.0054584453,
0.0071255565,
0.0034451394,
0.0114681125,
-0.010090057,
0.0041980282,
-0.0011545419,
0.0041677784,
-0.009632946,
-0.015447669,
0.0023779864,
0.020516224,
-0.011905057,
-0.011172335,
0.023595003,
0.03148689,
0.0065306397,
0.0149098905,
0.0026535976,
0.012294946,
-0.010742112,
0.020543113,
0.017101336,
-0.008752334,
-0.035116892,
0.000065961816,
0.0026922503,
-0.00904139,
-0.013141946,
-0.022600114,
0.00025880558,
-0.0024216808,
0.035116892,
0.022573225,
0.010829501,
0.011058057,
0.039392225,
0.0006852466,
0.0001545061,
0.014762002,
-0.0035661394,
-0.007871723,
-0.036676448,
0.005112251,
0.019588558,
-0.0029409726,
-0.008241446,
-0.022062335,
0.033342227,
0.0068432232,
-0.009357334,
0.0054584453,
0.0076095564,
-0.014923335,
0.016482892,
0.021269113,
0.010332057,
-0.004433306,
0.00674239,
-0.0035056393,
-0.0045744726,
-0.011683224,
0.007078501,
0.02739978,
-0.011031168,
0.0060197506,
0.009142224,
-0.023097558,
-0.012819279,
-0.016079558,
0.015030891,
-0.020260781,
-0.0048366394,
0.01663078,
0.004608084,
-0.01880878,
0.06679201,
-0.014896446,
-0.018338224,
0.009955612,
-0.02488567,
-0.009928724,
0.0068264175,
-0.0059458064,
-0.013746946,
0.018634003,
0.015084668,
0.0054584453,
-0.0024653752,
-0.0077843345,
-0.012133612,
-0.026270447,
0.006624751,
0.012234446,
-0.011414335,
-0.0028149309,
-0.012819279,
-0.00041992887,
-0.020785114,
-0.021484224,
0.002791403,
-0.034552228,
0.001342764,
-0.02573267,
-0.041785337,
-0.026606558,
0.016550113,
-0.022479113,
-0.009901835,
-0.0015234238,
0.033691783,
0.043102894,
0.028367782,
-0.00063819106,
-0.010500113,
-0.003855195,
0.005582806,
0.0069709453,
-0.008483445,
-0.0028989587,
0.0097136125,
0.0014125071,
0.005068556,
-0.005488695,
-0.0038417506,
-0.008712001,
0.0019578475,
-0.020691002,
0.001717528,
0.005673556,
-0.001339403,
-0.0017662641,
-0.0060163895,
-0.00096127787,
0.00094279175,
-0.02633767,
0.025047002,
-0.015380446,
0.016079558,
0.016792113,
0.010742112,
0.001297389,
0.016765224,
-0.049206674,
-0.034256447,
-0.033611115,
-0.00016374915,
0.029524004,
-0.0048063896,
-0.033422895,
0.010574057,
0.03275067,
-0.023057224,
0.0013234377,
-0.030034892,
-0.005297112,
0.01735678,
-0.027050225,
0.000054775614,
-0.6466241,
-0.0072129453,
0.006513834,
-0.0086515015,
0.026243558,
0.03205156,
0.02488567,
0.022748003,
-0.015703114,
0.032481782,
-0.015810668,
0.0073339455,
0.01919867,
-0.017639114,
-0.008752334,
-0.034390893,
0.0017007224,
-0.01505778,
0.011710113,
-0.002334292,
0.00007746312,
0.03646134,
-0.009444723,
-0.0031443199,
0.012187391,
0.019158335,
0.0071322788,
-0.03764445,
-0.009411112,
0.010634556,
-0.0015351877,
0.019239003,
0.0085573895,
0.014291446,
0.047969785,
-0.013585613,
-0.010963946,
0.020153224,
0.012160501,
0.027211558,
-0.02539656,
-0.005784473,
0.020059114,
0.018593669,
0.0019763336,
0.03344978,
0.005155945,
-0.0008957362,
0.006513834,
0.0025594863,
-0.0035627782,
-0.0061306674,
-0.019978447,
0.003438417,
0.025517559,
-0.020005336,
0.020838892,
-0.018849114,
-0.012543668,
0.030518893,
-0.021793447,
0.00010141104,
-0.018136557,
-0.028582891,
-0.0031644865,
0.032293558,
-0.018123113,
0.0030922226,
0.024347892,
-0.011219391,
0.013578891,
0.029040003,
0.010957223,
-0.020126335,
0.046706006,
0.023568114,
0.02488567,
0.010043001,
-0.040682893,
-0.0008251529,
0.0101303905,
0.014654446,
-0.0058113616,
-0.0043291114,
0.013236057,
0.028744226,
-0.003389681,
0.0074280566,
-0.007172612,
0.0007928022,
0.0048366394,
0.012294946,
-0.013794002,
-0.023487447,
-0.0057071676,
0.022519447,
-0.001615014,
-0.00044954868,
0.008906946,
0.006870112,
-0.019615447,
-0.0077238344,
-0.013007501,
0.01832478,
0.012012613,
0.008752334,
-0.025275558,
-0.01590478,
0.034928672,
-0.034767337,
0.018432336,
-0.014627557,
0.0019796947,
-0.010842945,
0.006238223,
-0.025342781,
0.0050147786,
-0.0036468059,
0.0019914585,
-0.04339867,
0.0059626116,
0.008644779,
-0.006755834,
-0.0006474341,
0.015125002,
0.010997557,
-0.0077977786,
-0.0011058057,
0.016012335,
-0.031029781,
0.0013007502,
-0.010990835,
0.03127178,
0.006123945,
0.020583447,
-0.020785114,
0.00958589,
0.010574057,
-0.012940279,
-0.026620002,
-0.0027863614,
-0.013531835,
-0.002678806,
-0.014775447,
0.0016595488,
-0.006624751,
-0.001324278,
0.006029834,
-0.00070835423,
-0.002909042,
0.008806112,
-0.04267267,
-0.0013948613,
0.011333668,
-0.0022300975,
-0.010842945,
0.025275558,
-0.03253556,
-0.00040858513,
-0.0129470015,
0.01672489,
-0.010560612,
0.00064911466,
0.009196001,
-0.004513973,
-0.019521335,
-0.026404893,
-0.010056445,
-0.01786767,
-0.014977113,
0.010116946,
-0.018660892,
0.0067390287,
0.015555224,
-0.0138477795,
0.039446004,
-0.025773004,
-0.008295223,
-0.0109841125,
0.0031695282,
0.008248168,
-0.013464613,
-0.01430489,
0.004682028,
0.021901002,
-0.002818292,
0.012933557,
-0.003283806,
-0.0026166253,
0.009975779,
0.0009150626,
0.026794782,
-0.020717891,
0.00031111288,
-0.023258891,
0.0066986955,
-0.0074078897,
0.0129940575,
-0.008059946,
0.01650978,
0.04907223,
-0.011891613,
0.02582678,
0.009290112,
0.026149448,
-0.012805835,
0.0087657785,
0.002482181,
0.018634003,
0.0056433063,
0.00771039,
-0.005999584,
-0.008053224,
-0.0012335279,
-0.012436112,
0.017289558,
0.007340668,
0.004520695,
0.005273584,
-0.010332057,
0.007932223,
-0.0036535282,
0.023837002,
0.006423084,
0.0035930283,
0.013404112,
0.007502001,
0.011817669,
0.008241446,
-0.020099446,
-0.012496613,
0.007354112,
0.02500667,
0.009256501,
0.018526446,
0.023716003,
-0.0018654169,
-0.005912195,
0.031755783,
0.022048892,
0.012960446,
0.02198167,
0.01348478,
-0.0020704446,
0.008638057,
-0.0055660005,
0.023124447,
0.031110449,
-0.002882153,
0.01663078,
0.024670558,
0.013168835,
-0.0077910563,
0.008113723,
-0.007112112,
-0.007838112,
-0.00037371358,
-0.00317457,
0.03377245,
0.015622446,
0.039661117,
0.014439335,
-0.01303439,
0.011797502,
0.027157782,
-0.0074011674,
-0.0067155007,
0.0015956877,
0.015461113,
-0.011528612,
0.0061541954,
-0.0011108473,
-0.009935446,
-0.01929278,
-0.012973891,
0.0011175696,
0.0060735284,
0.0062819174,
0.025073892,
0.01747778,
-0.0077977786,
-0.038424227,
0.0052903895,
0.03135245,
-0.007992723,
0.0028435003,
0.013195724,
-0.0068600285,
-0.019938113,
0.02108089,
0.01291339,
-0.015824113,
0.0009999307,
-0.025289003,
0.021551447,
-0.008355724,
0.02219678,
-0.012086557,
-0.0027645142,
-0.016456002,
0.0062449453,
-0.00837589,
-0.0013461252,
-0.02207578,
0.021457337,
0.019682668,
0.009868223,
0.016106447,
-0.010278279,
0.008839724,
0.016550113,
-0.0098749455,
-0.0033695144,
-0.011616002,
0.023702558,
0.01823067,
-0.021054003,
0.002134306,
0.020946447,
0.0031392782,
0.010063168,
-0.014049446,
-0.012288224,
-0.026203226,
0.025638558,
-0.0063222507,
-0.016832447,
0.036568895,
-0.0027208198,
0.00055836467,
-0.018002113,
-0.015461113,
0.042645782,
0.03258934,
0.021040559,
0.0036468059,
0.017128224,
-0.0050820005,
0.03132556,
0.034740448,
-0.0050080563,
-0.014372113,
0.021645559,
-0.008927112,
-0.0029628198,
-0.010802613,
0.031110449,
0.022748003,
0.014358669,
-0.025302447,
0.011333668,
0.015743446,
-0.012664668,
0.0025846947,
-0.047512673,
0.019319668,
-0.01287978,
0.024630224,
-0.008550668,
-0.0033997642,
-0.0045744726,
0.013861224,
0.009196001,
-0.008954001,
0.024321003,
0.0058281673,
0.010412724,
0.008759056,
-0.015474558,
-0.024347892,
0.020354891,
0.019884335,
0.02428067,
-0.024079002,
0.020825448,
0.0075759455,
-0.019158335,
-0.028314004,
0.027346004,
-0.014358669,
0.013726779,
-0.01786767,
-0.02522178,
-0.007885167,
-0.023420226,
0.00032938892,
0.005542473,
-0.012846168,
-0.019400336,
-0.010096779,
-0.021027114,
-0.013041113,
-0.003498917,
-0.01079589,
-0.004880334,
0.012335279,
-0.011286613,
0.030492004,
-0.00072684034,
0.0042350003,
0.01880878,
-0.028287115,
0.0072532785,
0.028582891,
-0.024966337,
0.00704489,
0.0075759455,
-0.024079002,
-0.018378558,
0.011649612,
-0.037940226,
-0.010049723,
0.011212668,
0.03347667,
0.00007657032,
-0.015622446,
0.015313224,
-0.008228001,
0.010318613,
-0.0016444238,
0.008476723,
0.014600668,
-0.014412446,
-0.03839734,
0.00634914,
-0.044743117,
0.00861789,
-0.02960467,
-0.0070112785,
-0.006897001,
-0.025275558,
-0.027130893,
0.022532891,
-0.0011629446,
0.011071501,
-0.010217779,
-0.0055290284,
-0.0038652783,
0.007938946,
0.013027668,
-0.0031695282,
0.025894003,
0.020879224,
0.0028653475,
-0.0035728614,
0.020153224,
0.03180956,
0.0017444169,
-0.011972279,
0.039661117,
-0.0030922226,
-0.03463289,
-0.043291118,
-0.0067356676,
0.013995668,
0.045603562,
-0.018123113,
-0.014667891,
-0.034928672,
0.004981167,
0.015703114,
-0.010184168,
-0.014856113,
0.0004251806,
0.004194667,
0.0030888615,
-0.012436112,
0.010043001,
0.051169563,
-0.037752006,
-0.00634914,
0.0015679585,
-0.027346004,
-0.00044618757,
-0.004046778,
-0.0029712226,
-0.023595003,
-0.02546378,
-0.030545782,
-0.023151336,
-0.0045946394,
-0.019037336,
0.023003448,
0.031594448,
0.028959338,
0.0020670835,
-0.0043896115,
0.012543668,
-0.007475112,
0.010708502,
-0.003238431,
-0.0030703754,
-0.007602834,
0.028556004,
0.006991112,
-0.0047425283,
0.0053441674,
-0.032186005,
0.026862003,
-0.0069709453,
-0.0079591125,
-0.01031189,
-0.011024446,
-0.05458445,
0.0065844175,
-0.0058348896,
0.00005860938,
-0.0066785286,
-0.04662534,
0.0091825565,
0.0015192224,
0.0044064173,
0.016684558,
-0.012234446,
0.020341447,
-0.0038383894,
0.022600114,
0.0031426393,
0.011205946,
-0.009068279,
-0.012637779,
-0.016469447,
-0.0029863475,
0.015851002,
0.021175003,
0.019548224,
0.0012326876,
0.0023174863,
-0.038558673,
0.022129558,
-0.041731562,
0.008140612,
0.012463002,
-0.018418891,
0.007535612,
0.003771167,
-0.027614892,
-0.007925501,
0.016496336,
-0.0014477988,
-0.025840225,
0.013457891,
-0.03127178,
-0.002379667,
-0.008335557,
-0.038720004,
0.012503335,
-0.016671114,
0.03519756,
0.005330723,
-0.0086515015,
-0.008819557,
0.016173668,
0.008779223,
0.0019410419,
0.019844003,
-0.013262946,
-0.008537224,
-0.0005852535,
-0.003855195,
0.012866335,
-0.042887785,
-0.035547115,
0.036757115,
0.021968225,
-0.005189556,
0.01115889,
-0.021269113,
-0.026996449,
0.027964449,
0.006991112,
-0.0045408616,
0.013538557,
-0.043291118,
-0.009518668,
0.015918225,
-0.041919783,
0.019911224,
-0.0017049238,
-0.028959338,
-0.003211542,
-0.008691834,
-0.00079154177,
0.0153266685,
0.018150002,
-0.010957223,
-0.017760113,
-0.02473778,
0.023447113,
0.008160778,
0.017114779,
-0.0011663057,
-0.02319167,
0.038693115,
-0.0022821948,
-0.004641695,
0.02633767,
-0.020664115,
-0.00892039,
-0.002697292,
-0.01820378,
-0.03320778,
-0.026633447,
-0.0013872988,
0.020570002,
0.020570002,
-0.011454668,
0.008369167,
-0.017854225,
-0.014842669,
-0.0018452503,
-0.0076633343,
-0.0070986673,
-0.03301956,
-0.020005336,
-0.027722448,
-0.006295362,
0.0049173064,
0.0028619864,
0.0038148616,
0.0062651117,
0.0072936118,
-0.009377501,
0.02125567,
0.016066113,
-0.0002092292,
-0.028448448,
-0.0021023753,
-0.030223114,
-0.003952667,
0.021914447,
0.023729447,
-0.015246002,
-0.015071224,
0.00046551393,
-0.011239557,
-0.017666003,
-0.0075490563,
0.016792113,
0.0047122785,
-0.0012629377,
-0.0069575007,
-0.024952892,
0.017733224,
-0.047270674,
0.019333113,
0.023487447,
-0.028798003,
0.020287668,
0.0023242086,
0.021269113,
0.016052669,
-0.0075759455,
-0.010957223,
-0.020570002,
0.041408893,
-0.020086002,
-0.0142645575,
-0.022183336,
-0.0044433894,
-0.0138477795,
-0.00976739,
0.013074724,
-0.008039779,
-0.015044335,
-0.014103224,
-0.00058735424,
0.00048568062,
-0.023353003,
-0.016482892,
-0.0022872363,
-0.0049710837,
-0.023016892,
0.0014301529,
-0.022008559,
0.04444734,
0.020086002,
-0.016321557,
-0.015286335,
-0.014479669,
-0.04584556,
-0.00076549314,
-0.009048113,
0.01445278,
-0.0016561877,
0.006147473,
0.014466224,
0.026902337,
-0.009935446,
0.0017208891,
-0.026566226,
-0.019158335,
0.0035930283,
-0.015676225,
0.020059114,
0.00038001567,
-0.038451117,
-0.0005146702,
0.021605225,
-0.0041106394,
0.0063121673,
0.01793489,
-0.002977945,
0.0035930283,
-0.0013595696,
0.01883567,
-0.00278132,
-0.00034220316,
-0.02391767,
-0.03931156,
0.0012083196,
-0.0031644865,
-0.0072532785,
-0.011064779,
-0.011488279,
-0.014856113,
0.00091086124,
-0.007300334,
-0.026741004,
-0.007918779,
-0.0046887505,
-0.014681336,
-0.006382751,
-0.0077036675,
0.010782446,
0.02161867,
-0.0018301252,
0.04447423,
-0.012678113,
0.005246695,
0.015125002,
-0.017182002,
0.014170446,
-0.008422946,
-0.0081876675,
0.0027897225,
0.018150002,
-0.006752473,
-0.003154403,
-0.010701779,
-0.025141114,
-0.019131446,
0.014143557,
-0.010224502,
-0.0154880015,
0.0047492506,
0.004493806,
-0.012980613,
0.0026048615,
-0.027856892,
0.006930612,
-0.0034232922,
-0.0116294455,
0.0038182228,
-0.00825489,
0.00066381955,
0.004127445,
-0.021242226,
-0.009942167,
0.013632668,
0.17660624,
-0.006574334,
0.0059256395,
0.017182002,
0.015340113,
0.025289003,
0.026915781,
-0.003287167,
-0.01944067,
0.02764178,
0.049986452,
-0.01542078,
0.0005932362,
-0.0016074516,
-0.0020418752,
0.008759056,
-0.012980613,
-0.030061781,
0.0016461044,
-0.020233892,
-0.0017746668,
-0.0021040558,
0.037967116,
-0.010634556,
0.042457562,
0.0142645575,
0.024616782,
0.00081801054,
0.035036225,
0.01457378,
-0.012725168,
0.002482181,
0.013162113,
0.023850447,
-0.007777612,
-0.013760391,
-0.0014360349,
-0.014869558,
0.009128779,
0.0028115697,
-0.009417835,
-0.019615447,
-0.032454893,
-0.016859336,
0.000059187074,
0.011595835,
0.0044097784,
-0.026767893,
-0.0062281396,
-0.010036279,
-0.03127178,
-0.017760113,
0.00036573096,
0.0028787921,
0.0052332506,
-0.0012923473,
0.016146779,
0.006749112,
-0.012866335,
-0.012294946,
0.0011385765,
-0.013236057,
-0.019723002,
0.014708224,
-0.011696668,
0.018365113,
-0.0097136125,
-0.005246695,
-0.01944067,
-0.0050080563,
0.017195446,
-0.019118002,
-0.02863667,
0.007078501,
0.00050542713,
-0.010668168,
0.021766558,
0.01539389,
0.014883002,
0.014708224,
-0.011367279,
0.0016982016,
-0.028475337,
0.00057012856,
-0.024307558,
-0.037725117,
0.0129470015,
0.011051334,
-0.01182439,
-0.00048820145,
-0.005935723,
-0.0045375004,
-0.016550113,
0.0014679654,
0.026082225,
0.0076162787,
-0.011696668,
0.0018065975,
0.013074724,
-0.0014125071,
-0.020341447,
0.0883569,
0.004604723,
0.009733779,
-0.005965973,
-0.0042921393,
-0.02500667,
-0.0035829449,
0.011918501,
-0.00025796532,
-0.010789168,
-0.027265336,
-0.010600946,
-0.020825448,
-0.009727057,
0.03643445,
0.02391767,
-0.01817689,
0.0055861673,
-0.02001878,
0.007737279,
-0.0015998891,
0.0045677507,
0.034901783,
0.020462448,
-0.006292001,
0.002349417,
-0.00056802784,
-0.01517878,
-0.013646113,
0.011985724,
-0.01829789,
-0.0075490563,
0.0017864307,
0.00051635073,
0.020314557,
-0.0047089173,
-0.0017444169,
-0.004379528,
0.012980613,
-0.002352778,
-0.014183891,
0.0016612294,
0.0052366117,
0.031433117,
0.0018939864,
0.00795239,
0.005112251,
-0.026499003,
0.007152445,
0.0026956114,
-0.012086557,
-0.0077977786,
-0.004218195,
0.024240335,
-0.01079589,
0.020220447,
-0.03901578,
-0.014291446,
0.006755834,
-0.004819834,
0.013390669,
0.03277756,
-0.009814446,
0.021914447,
0.006876834,
-0.17004536,
0.024374781,
0.0149098905,
-0.02050278,
0.026888892,
-0.00994889,
0.031890225,
-0.00088397233,
-0.018150002,
-0.01112528,
0.047700893,
-0.0066818898,
0.0019326392,
-0.006325612,
0.0074078897,
0.00892039,
-0.005485334,
0.051277116,
0.008779223,
0.03132556,
0.025087336,
0.0020788475,
0.016940001,
-0.017773557,
0.009753945,
-0.010426168,
-0.013088169,
0.021632114,
-0.020395225,
-0.01396878,
-0.01554178,
0.0029762643,
0.045738004,
0.012315112,
-0.025275558,
0.0024452086,
-0.028798003,
-0.02379667,
-0.004675306,
0.0029073614,
0.023702558,
0.018956669,
0.0076364456,
-0.02766867,
-0.012194113,
0.009249778,
0.020086002,
-0.013478057,
0.006991112,
0.008893501,
-0.005337445,
-0.0062617506,
0.008523779,
0.00028989586,
0.0019091114,
0.027856892,
-0.017020669,
0.011636168,
0.02001878,
-0.023500891,
-0.013289835,
-0.02098678,
0.0021914446,
0.010816057,
-0.0013116738,
-0.012194113,
0.015676225,
-0.018647447,
0.018123113,
0.019924669,
-0.018418891,
-0.0084431125,
0.011528612,
-0.0094581675,
0.05092756,
0.018405447,
-0.022304336,
0.0071658897,
-0.0069373343,
-0.006594501,
-0.002557806,
-0.002882153,
-0.020032225,
-0.0097136125,
0.023393337,
0.025047002,
0.014130113,
-0.0039291396,
0.009787557,
-0.023944559,
0.0028871947,
-0.05727334,
0.0010327015,
-0.0051660286,
-0.011851279,
0.033853114,
-0.012832724,
-0.0009932085,
0.00086212513,
0.0036871394,
-0.008201112,
0.009310279,
-0.017881114,
-0.0018015557,
0.009982501,
0.012839446,
-0.011716835,
0.009552279,
0.04654467,
-0.0030098753,
-0.002682167,
0.0006007987,
0.009068279,
0.0038686395,
0.0049878894,
0.018620558,
-0.008960723,
-0.019185225,
0.0028266949,
-0.02912067,
0.044366673,
0.013014223,
-0.0029645003,
0.024536114,
0.00018706686,
-0.00952539,
-0.12627023,
-0.021511113,
0.0080733895,
-0.0131553905,
0.005767667,
0.01638878,
-0.013915001,
-0.014466224,
-0.0030182782,
0.034202673,
-0.028959338,
-0.0069507784,
0.006839862,
-0.012657946,
0.027856892,
0.0033762364,
0.0063793897,
-0.024065558,
-0.013726779,
0.022788337,
-0.013007501,
-0.018499557,
0.0070986673,
-0.021968225,
0.012469724,
-0.007058334,
-0.005186195,
0.0109841125,
0.0029006393,
0.043667562,
0.0071793343,
0.03148689,
-0.006745751,
0.003241792,
-0.003302292,
-0.008033057,
0.009216168,
-0.043775115,
0.042108007,
-0.01269828,
0.01941378,
0.022264002,
0.023353003,
-0.005760945,
0.0073742787,
0.0051794727,
-0.025786448,
0.013565446,
0.0020670835,
-0.004342556,
-0.020126335,
-0.023810115,
-0.02636456,
0.0034098476,
0.005334084,
-0.007118834,
0.0048769726,
0.00079490285,
-0.011152168,
0.0010839584,
-0.012832724,
-0.018580224,
-0.0039425837,
0.02957778,
0.017276114,
-0.03713356,
-0.002951056,
-0.0084431125,
0.008107001,
-0.019010447,
-0.0055895285,
0.0005827327,
-0.012133612,
0.009720335,
-0.028959338,
0.0048736115,
-0.024186559,
-0.0049509173,
0.001899028,
-0.02479156,
-0.012859613,
-0.02476467,
0.03465978,
-0.009686723,
0.014627557,
0.02292278,
0.013047835,
-0.007979278,
-0.005999584,
-0.008355724,
0.021564892,
0.034122005,
0.01505778,
-0.012436112,
0.011347112,
0.008691834,
0.012234446,
-0.017612224,
0.0059256395,
0.023353003,
-0.00020061634,
-0.0022821948,
-0.05071245,
0.017518112,
0.008913668,
-0.015259447,
-0.0019158336,
-0.0013192362,
0.026162893,
0.0030250004,
0.0076162787,
0.018849114,
-0.025450336,
0.026230114,
-0.0050147786,
0.026378004,
-0.0040501393,
-0.007918779,
0.012570557,
0.017007224,
0.023702558,
0.0032182643,
-0.012389057,
-0.004312306,
-0.003072056,
0.028717337,
0.012752057,
-0.0034400977,
-0.003362792,
0.035816003,
-0.026539337,
0.00892039,
0.013209168,
-0.0082347235,
0.0014301529,
0.008853167,
0.00017897919,
-0.014614113,
-0.004419862,
0.018983558,
0.023205115,
0.029308893,
-0.013713335,
-0.025450336,
0.0086044455,
-0.01689967,
-0.024993226,
-0.0047458895,
-0.046060674,
0.020933002,
-0.0071995007,
-0.031137338,
-0.0050483895,
0.0007507883,
-0.0007512084,
-0.043344893,
-0.027561115,
0.02766867,
0.02343367,
0.011622723,
-0.01735678,
-0.033073336,
0.030465115,
0.010829501,
-0.003771167,
0.009491779,
0.0036669727,
-0.023675669,
0.0027493893,
0.0058315285,
0.009801001,
-0.013511668,
-0.026283892,
0.0010049724,
-0.021766558,
0.01929278,
0.0075759455,
-0.011958835,
-0.0070717786,
0.015219113,
-0.012241168,
0.016792113,
0.03377245,
-0.006386112,
-0.026082225,
0.023944559,
0.02222367,
-0.0025981392,
-0.012261335,
0.03084156,
-0.023514336,
0.01206639,
-0.013558724,
0.0041677784,
-0.002836778,
-0.0024805004,
0.020543113,
0.011414335,
-0.00704489,
-0.000105559906,
0.0053811395,
0.013928446,
-0.01097739,
0.01699378,
0.004698834,
-0.02682167,
-0.015380446,
0.0044803615,
-0.01856678,
-0.022774892,
-0.026727559,
-0.004080389,
0.017114779,
0.017679447,
-0.005969334,
-0.0001720469,
-0.00072347926,
0.002969542,
-0.0016452641,
0.0076162787,
-0.009276668,
0.013531835,
-0.006009667,
0.013195724,
0.005330723,
0.005068556,
-0.0047492506,
0.013807446,
0.0053811395,
-0.022156447,
0.022600114,
0.008772501,
0.021524558,
0.011548779,
-0.007885167,
0.0005772709,
-0.00028254345,
-0.058348894,
0.0024754587,
0.012469724,
0.011575668,
0.0777089,
-0.003767806,
-0.021753114,
-0.009881668,
-0.010264834,
0.0072734454,
0.009760668,
0.007871723,
0.00040690455,
-0.0062483065,
0.0067726397,
-0.012725168,
-0.015703114,
-0.05635912,
-0.01823067,
0.026902337,
0.001914153,
0.0047694175,
0.0085573895,
-0.032186005,
-0.0020704446,
-0.021242226,
0.034848005,
-0.007434779,
-0.019696113,
-0.029819781,
0.017531557,
-0.011226112,
-0.01793489,
-0.0074078897,
-0.015877891,
0.0009184237,
-0.023931114,
-0.011071501,
-0.004826556,
-0.0032938893,
0.0046215286,
-0.038746893,
0.010648001,
-0.00970689,
-0.023931114,
0.006308806,
-0.014143557,
-0.046275783,
-0.033342227,
-0.025047002,
-0.005465167,
-0.014762002,
-0.024119336
] |
Finding new treatment-shortening antibiotics to improve cure rates and curb the alarming emergence of drug resistance is the major objective of tuberculosis (TB) drug development. Using a matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging suite in a biosafety containment facility, we show that the key sterilizing drugs rifampicin and pyrazinamide efficiently penetrate the sites of TB infection in lung lesions. Rifampicin even accumulates in necrotic caseum, a critical lesion site where persisting tubercle bacilli reside. In contrast, moxifloxacin, which is active in vitro against | [
-0.021048348,
-0.00006378416,
-0.0066962773,
-0.043507155,
-0.0019071676,
0.025971385,
-0.022702923,
-0.022540178,
-0.03127416,
0.009574829,
0.021794263,
0.027137723,
0.021170408,
0.021238217,
-0.0035600462,
0.013392555,
0.0388418,
0.016993286,
-0.013080627,
-0.020261748,
-0.021889199,
0.016288059,
-0.005926629,
-0.010063063,
-0.01721028,
0.016328745,
0.005363803,
-0.027910762,
-0.0477114,
0.009622296,
0.0081304675,
-0.00730318,
-0.01453855,
-0.015162406,
-0.024696548,
-0.008625483,
0.026066318,
-0.00033841628,
0.005943582,
-0.011534549,
0.0006581847,
0.0064182547,
0.011249745,
0.012721231,
0.008639045,
-0.00997491,
0.02032956,
-0.005991049,
-0.034908794,
-0.012104156,
0.013026378,
0.00057638844,
-0.014755543,
-0.0116498275,
-0.005468909,
-0.03330847,
-0.0053502405,
0.021929884,
0.0065809996,
-0.019705703,
-0.028778736,
-0.007866006,
-0.03507154,
0.021740016,
-0.0064691124,
0.021482335,
-0.012477114,
0.027151285,
0.0053536315,
0.01825456,
0.034312062,
0.035614025,
0.010090188,
0.0125313625,
0.036726113,
-0.0058316947,
-0.00031468263,
0.007825321,
0.014389368,
0.010998847,
0.010781854,
0.016125314,
-0.029483963,
0.014755543,
0.019665016,
0.0023191157,
-0.002614091,
0.024560928,
0.0012790738,
-0.0047670715,
-0.016206685,
0.02489998,
0.011921069,
0.025401777,
-0.025401777,
0.01760358,
-0.0037770395,
0.031219909,
-0.0034227301,
-0.02580864,
-0.005957144,
-0.008137248,
-0.0047568996,
-0.019529397,
-0.0016011731,
0.023164034,
-0.010144436,
-0.013507832,
0.028561741,
-0.006675934,
-0.004275446,
0.047548655,
0.010293619,
-0.039140165,
0.03338984,
0.0037702583,
0.026744423,
-0.037078727,
0.0057265884,
-0.024601614,
0.0021750187,
0.018525802,
0.01238896,
-0.01512172,
0.044402253,
0.002724283,
-0.00893063,
-0.019583644,
0.0018444429,
-0.0029565336,
0.013277276,
0.015894758,
0.011019191,
0.0035057978,
0.014172374,
0.015216654,
-0.024818607,
-0.025252594,
-0.03512579,
-0.03330847,
0.018824168,
0.03753984,
-0.004282227,
-0.021658642,
0.002302163,
0.028914355,
0.01871567,
0.007404896,
0.010937818,
0.015596393,
-0.0037397437,
-0.032576118,
-0.013779074,
-0.011120906,
-0.008706856,
-0.007425239,
-0.0073438664,
0.017033974,
-0.021889199,
-0.0057808366,
-0.018403742,
-0.017874822,
0.014565675,
0.002098732,
0.034013696,
0.025130535,
0.026323998,
0.000110191904,
0.0005674883,
0.014823354,
0.008266088,
0.015745575,
0.0016384688,
0.021468773,
-0.007974504,
0.0104767075,
0.0029734862,
0.0035803893,
0.0019732828,
-0.008055876,
-0.004878958,
0.012361837,
0.011242964,
0.021143284,
-0.024140503,
0.013209466,
0.00018912744,
-0.0032091273,
0.010259714,
-0.043398656,
0.009222215,
0.01733234,
-0.016450804,
-0.019380214,
-0.6288465,
-0.023367465,
0.002295382,
-0.0081304675,
-0.0113514615,
0.0042856173,
0.004607717,
-0.007940598,
-0.0002737845,
0.030433308,
-0.0027785313,
0.029022852,
0.010727606,
-0.012945006,
-0.011270089,
-0.018498678,
-0.011676951,
-0.015650641,
0.002176714,
-0.019190343,
-0.004017766,
0.027653081,
-0.0058181323,
-0.00027060587,
-0.007960942,
0.0069336137,
0.019027598,
-0.014741981,
0.006184309,
0.014321557,
-0.028832983,
0.0063470537,
-0.009364616,
0.011493864,
0.05346172,
-0.013324744,
0.00072980946,
0.02313691,
0.016735608,
0.010483488,
-0.0107750725,
0.007248932,
0.0246423,
-0.01681698,
-0.000531464,
0.02522547,
0.03466468,
0.010632671,
-0.0076761376,
-0.026635926,
0.003597342,
-0.007927036,
-0.025835764,
0.017617142,
0.039004542,
0.03273886,
0.013582423,
-0.033416968,
0.033199973,
0.007960942,
-0.016477928,
0.006506408,
0.0112158405,
-0.020424493,
-0.043452907,
-0.0026903776,
-0.009961348,
0.0046246694,
0.015094596,
-0.004634841,
0.025415339,
0.032223504,
-0.011826134,
0.01798332,
0.015487896,
0.04179833,
-0.011527768,
-0.008795009,
-0.017630704,
0.0023886214,
-0.003539703,
0.001251102,
-0.038028073,
-0.0031803078,
0.029348342,
-0.0016316877,
-0.008591578,
-0.014104564,
0.015392961,
0.025673019,
0.009981691,
0.017834136,
-0.013243372,
-0.042150944,
-0.024710111,
0.011080219,
0.008652607,
-0.00593341,
0.0050010174,
-0.0066250763,
-0.045080356,
-0.019759951,
0.015677765,
0.004939988,
0.015894758,
-0.013860446,
-0.017413711,
-0.008652607,
0.028371872,
-0.036346376,
-0.0071879025,
-0.0019919307,
-0.009629077,
-0.0041228724,
0.044375125,
-0.026161253,
0.015243778,
-0.006401302,
-0.0061876993,
-0.043669898,
0.019800637,
0.0059944396,
0.009181528,
-0.01609819,
-0.00423815,
0.0012324541,
0.017495085,
-0.011582017,
-0.0026242626,
-0.014511426,
-0.023828575,
-0.018335933,
0.030596053,
-0.02106191,
0.0144300535,
0.01669492,
0.009242558,
0.006957347,
-0.011819353,
-0.04394114,
-0.024303248,
-0.02953821,
0.012931444,
0.022513054,
-0.009174747,
-0.018756358,
-0.01336543,
0.008144029,
-0.005885943,
-0.0020190547,
0.005638435,
0.0017350987,
-0.008747542,
0.011778667,
0.020614361,
-0.02607988,
-0.00802197,
-0.026391808,
-0.008767885,
-0.011236183,
0.004465315,
-0.011120906,
0.0000015148075,
-0.008808571,
-0.01518953,
-0.039709773,
0.025984947,
0.021631518,
0.010842883,
-0.024655862,
0.0070115956,
-0.018864853,
-0.0068488508,
0.009364616,
-0.00080355327,
0.025862888,
-0.01075473,
-0.0021987522,
-0.008523768,
-0.0005670645,
-0.00815081,
0.007974504,
0.024940666,
0.026974978,
0.0027819218,
0.017196719,
0.011724419,
-0.026039194,
0.0051637623,
0.039140165,
-0.018213874,
-0.009825727,
-0.021631518,
0.008923849,
0.0054282225,
-0.009039126,
0.03357971,
0.022648674,
0.0032413371,
0.015243778,
-0.016762732,
-0.02888723,
0.032793112,
-0.021224655,
0.0026259578,
-0.024954228,
-0.0014053705,
-0.039302908,
0.033715334,
0.011609141,
-0.0021038176,
-0.010815759,
-0.02041093,
-0.004685699,
0.0067030583,
0.031165661,
0.009764698,
-0.0023648879,
-0.020166814,
-0.003980471,
-0.016355868,
-0.00022546959,
0.03298298,
-0.007113311,
-0.028182004,
0.002385231,
0.016179562,
0.01532515,
-0.0073845526,
-0.007899912,
-0.006530142,
0.00172747,
0.037594087,
0.010320744,
0.012985692,
-0.003905879,
-0.008354242,
-0.014484302,
0.046463687,
-0.005614701,
-0.0076693567,
-0.0025140706,
0.0029853529,
0.018322371,
0.018634299,
0.031626772,
0.020126127,
0.027436089,
-0.0067132297,
0.0017334034,
-0.02353021,
-0.000971384,
-0.018566487,
-0.028670238,
0.003376958,
-0.009439208,
0.02744965,
0.021278905,
0.046707805,
0.022933478,
-0.0063843494,
0.0016172781,
0.007662575,
-0.018349495,
0.03219638,
0.0057537127,
-0.0045873737,
-0.01512172,
-0.018349495,
0.0112090595,
-0.01584051,
0.0013138265,
0.024669424,
-0.017101783,
0.010571642,
0.00036490473,
-0.020749982,
0.0007454906,
0.018051129,
-0.00638774,
-0.031084288,
-0.03103004,
0.031382654,
-0.00008089569,
-0.012782261,
-0.02229606,
-0.026907168,
-0.0046178885,
-0.011724419,
0.015786262,
0.021333152,
0.007425239,
0.03037906,
0.0134128975,
-0.008998441,
-0.024710111,
0.009818946,
-0.002341154,
0.0021394182,
0.023801452,
-0.023245405,
-0.007594765,
-0.0011807486,
-0.023598019,
0.021007663,
-0.011724419,
-0.006764088,
-0.017427273,
-0.008218621,
-0.013860446,
0.007581203,
0.016803417,
0.00018457144,
-0.0015206482,
-0.021563709,
0.026798671,
-0.016206685,
0.0063707875,
0.008510206,
-0.0206008,
-0.0044042855,
-0.031925138,
0.015243778,
0.0009010307,
0.02555096,
0.00952058,
-0.01356208,
0.009269682,
0.0254289,
0.012117719,
0.009391741,
-0.02529328,
0.007208246,
-0.020193938,
0.0006857327,
0.0012672069,
0.024506679,
0.02926697,
0.0034447685,
0.015270903,
0.015569269,
-0.02522547,
-0.013006035,
-0.00014229589,
0.017006848,
-0.009364616,
0.016220247,
0.0077371667,
0.03612938,
-0.010714044,
0.009608734,
-0.0017376415,
0.02327253,
-0.020709297,
-0.0052519157,
0.02327253,
-0.011466739,
0.026418932,
-0.010029159,
-0.021306029,
0.010632671,
-0.008625483,
0.010388553,
0.008123687,
0.010374991,
0.028209127,
0.0054146606,
0.02659524,
-0.0028700752,
0.008835696,
-0.0194209,
0.011961755,
-0.010958161,
-0.03070455,
0.035152912,
0.004021157,
-0.015135282,
-0.029700955,
0.012653421,
-0.0040720147,
-0.0100359395,
0.0070726248,
-0.02320472,
-0.002458127,
-0.009629077,
-0.03463755,
0.015921883,
-0.013914694,
-0.015881196,
0.0061029363,
-0.014687733,
0.012470333,
-0.029890826,
0.01563708,
0.0012053299,
-0.015854072,
-0.0064962367,
0.00365159,
0.01192785,
0.0048653963,
0.019366652,
-0.005312945,
0.0029294093,
0.018661423,
-0.014443615,
0.004719604,
0.005435004,
-0.05389571,
0.016328745,
-0.0008840781,
0.011181936,
-0.026093442,
-0.05156303,
0.01630162,
0.011907507,
0.0121245,
0.0131213125,
0.0075066113,
-0.002424222,
0.01748152,
0.011100563,
0.010714044,
-0.008049095,
-0.024371058,
-0.012782261,
-0.023353903,
-0.0016486404,
-0.016708484,
0.003017563,
-0.0073777717,
-0.020627925,
0.009988472,
0.0051400284,
-0.010673357,
0.00040516714,
-0.010829321,
-0.007452363,
0.002275039,
0.012477114,
0.0044314098,
-0.009276463,
0.01232115,
-0.0011443006,
0.013765512,
-0.0007391334,
-0.013955381,
0.02066861,
0.022011256,
-0.010056282,
0.005058656,
0.012477114,
-0.026717298,
-0.02880586,
-0.014199498,
-0.0067979926,
0.05004408,
0.0032447278,
-0.026934292,
-0.0477114,
-0.010449583,
0.0036821049,
0.0030870684,
-0.0057808366,
-0.018566487,
0.0066657625,
0.012951787,
-0.0049840645,
-0.0057401503,
0.011127687,
-0.026418932,
0.0017800231,
0.030460432,
-0.004004204,
0.029239845,
-0.018132502,
-0.008123687,
-0.031925138,
0.016342307,
-0.047168914,
-0.016247373,
-0.009690107,
-0.009798603,
0.021943446,
0.03612938,
0.026703736,
-0.016193124,
-0.00039605514,
-0.00017397606,
0.016762732,
0.007296399,
0.012287245,
0.012680545,
-0.0026327388,
0.027937885,
0.04779277,
-0.012999254,
-0.0017376415,
-0.02536109,
0.008266088,
0.022526616,
-0.009215434,
-0.009561267,
-0.013067065,
-0.0157727,
-0.043181665,
-0.0033854344,
-0.014647047,
-0.0056180917,
-0.042720553,
-0.018430868,
0.04179833,
-0.008984879,
0.024940666,
0.0029870481,
0.0032548993,
-0.012592392,
0.011982098,
0.001079033,
0.007832102,
-0.009106937,
-0.0060961554,
-0.0004920492,
-0.015691327,
-0.0024564317,
-0.0028090458,
-0.0009578219,
0.029402591,
-0.02164508,
0.01016478,
0.02197057,
-0.012585611,
-0.015894758,
-0.017467959,
-0.028073506,
-0.029619584,
-0.0061334507,
-0.024927104,
-0.036075134,
0.017156031,
0.007065844,
-0.00060902216,
0.019068286,
-0.010517393,
0.0051671527,
0.031111412,
-0.0031786126,
0.029999321,
-0.0010858141,
0.0075405166,
0.005984268,
0.0029633145,
-0.01649149,
-0.01798332,
-0.0076557943,
-0.010666576,
0.035559773,
0.035749644,
-0.012856852,
-0.007113311,
0.016993286,
0.004021157,
-0.00014621617,
-0.03325422,
0.019393776,
-0.03219638,
-0.017223842,
-0.03176239,
-0.011270089,
-0.05091205,
0.0043432564,
-0.031219909,
0.013955381,
-0.015352275,
-0.0059808777,
-0.008354242,
-0.0053231167,
-0.016030379,
0.01167017,
-0.004068624,
-0.013928257,
-0.0058622095,
-0.014864041,
-0.008584796,
0.0013231505,
-0.00991388,
0.02991795,
0.0071472162,
0.012639859,
0.012938225,
0.014647047,
-0.012110937,
-0.01636943,
0.008591578,
0.038353562,
0.002517461,
-0.0017884993,
-0.0010281752,
-0.006950566,
-0.0018851291,
-0.0169526,
-0.00012544924,
-0.012395741,
0.006604733,
-0.0007200617,
0.012083814,
0.0097511355,
-0.026649488,
-0.011846477,
-0.016979724,
0.004373771,
0.013317963,
-0.011290432,
0.024764359,
-0.040116634,
-0.012477114,
0.009005222,
0.014199498,
0.009941005,
-0.018240998,
0.0030582491,
-0.03037906,
0.0145792365,
-0.033850953,
0.014063877,
0.015582831,
-0.015582831,
-0.008876381,
-0.002490337,
-0.0050620465,
-0.04082186,
-0.0016808504,
-0.028507493,
-0.0138468845,
-0.019990506,
-0.0138401035,
0.0025649285,
0.0074320203,
-0.046626434,
0.009283244,
0.001147691,
0.0018936055,
-0.004556859,
-0.019027598,
0.027097037,
-0.009079813,
0.03349834,
0.010076626,
-0.031328406,
-0.016071064,
-0.0014765715,
0.00089001155,
0.000817963,
-0.02744965,
-0.013968943,
-0.018566487,
0.012680545,
-0.010971723,
-0.00024941514,
0.018932665,
0.0076490133,
-0.015528582,
0.0005331593,
0.017576456,
-0.0071404353,
-0.00952058,
-0.0023360683,
-0.0015893063,
-0.011371804,
-0.035695396,
-0.007743948,
0.02150946,
-0.021590833,
-0.04556859,
-0.014714858,
-0.038624804,
0.026256187,
-0.004204245,
-0.01669492,
-0.0062928055,
0.005906286,
-0.024560928,
-0.0057198075,
-0.021129722,
0.010280057,
0.0070726248,
0.01277548,
-0.0048213196,
0.027829388,
0.002224181,
0.015867634,
0.0063402727,
-0.007438801,
0.023231843,
-0.017237404,
0.04451075,
-0.017440835,
-0.05286499,
0.009968129,
0.021346714,
-0.0061809183,
-0.0026412152,
0.020804232,
0.004133044,
-0.017522208,
0.004838272,
-0.012151624,
-0.0073845526,
0.00437038,
0.026229063,
-0.0035871703,
-0.005651997,
0.02340815,
0.030460432,
-0.0016469451,
0.0007484573,
0.020058317,
0.010517393,
0.012192311,
0.010381772,
-0.00874076,
0.01277548,
-0.028398996,
0.034339186,
0.017766325,
0.017820574,
-0.002634434,
0.0013121313,
-0.017820574,
0.002698854,
0.011710856,
-0.013046721,
-0.023598019,
0.017644268,
-0.00091628806,
0.016057502,
0.010415678,
-0.002286906,
0.013792636,
-0.0007645623,
-0.00065606565,
-0.0023970976,
-0.021726454,
0.024384622,
0.006682715,
0.008774666,
-0.029755205,
-0.000412372,
-0.019054724,
-0.00093578355,
-0.016735608,
0.011982098,
-0.0074930494,
0.015732013,
-0.022811418,
-0.008096562,
0.011887164,
-0.0034532447,
-0.029728081,
0.008910287,
0.010714044,
0.19355801,
0.0014257136,
0.002047874,
0.020248186,
0.0061707464,
0.026771547,
0.021007663,
-0.022472367,
0.0027022446,
0.01753577,
0.031111412,
-0.010076626,
-0.004387333,
0.004346647,
-0.010049501,
0.024086256,
-0.015284465,
-0.002756493,
-0.011270089,
0.00033439003,
0.002732759,
0.004960331,
0.0011087001,
0.008455957,
0.018322371,
0.002959924,
-0.018322371,
0.0029819624,
0.0109242555,
-0.013107751,
-0.00678104,
0.000632332,
-0.008103343,
0.0051942766,
-0.013928257,
-0.020085441,
-0.019488709,
-0.015854072,
-0.0011392147,
0.016030379,
0.00919509,
0.016260935,
-0.025740828,
-0.01551502,
-0.014769105,
0.0011036143,
-0.010910694,
-0.0061910897,
-0.01368414,
-0.0037838204,
-0.01662711,
-0.00076159555,
0.016871229,
0.009961348,
0.006943785,
-0.017467959,
0.020343121,
0.017888384,
-0.014036753,
0.016030379,
-0.020031193,
0.0042415406,
-0.030324811,
0.031409778,
-0.024343934,
0.035505526,
-0.019732827,
0.01563708,
0.0134061165,
0.00082050584,
0.008205059,
-0.003905879,
-0.019380214,
-0.009174747,
-0.0060656406,
-0.022987727,
0.009527362,
0.012456771,
0.014552113,
0.026771547,
0.0027615787,
-0.024533803,
-0.027680207,
0.011466739,
-0.036481995,
-0.0110598765,
-0.000918831,
0.006638638,
-0.004950159,
0.01674917,
-0.017061098,
-0.011053096,
-0.0045534684,
-0.010836102,
0.02032956,
0.007940598,
-0.0002231386,
-0.004739947,
0.0030531634,
-0.013799417,
-0.029239845,
0.06829864,
-0.01994982,
0.008693294,
-0.012334712,
0.005184105,
-0.025903573,
0.006811555,
0.0029853529,
-0.0019495491,
0.02953821,
-0.027205532,
-0.004166949,
-0.018864853,
0.009500237,
0.027883638,
0.025469586,
-0.020180376,
0.023570895,
-0.005170543,
0.01904116,
-0.0120905945,
0.0019970164,
0.014091002,
-0.026690174,
-0.011805791,
-0.027436089,
0.012077033,
0.002236048,
-0.017996881,
-0.013223029,
-0.0049060825,
-0.017793449,
-0.0024530413,
-0.014199498,
0.014348681,
0.0027395403,
-0.013487489,
-0.013724825,
0.008632264,
-0.0024360886,
0.02777514,
0.008564454,
0.026500305,
0.007398115,
-0.025116973,
0.014335119,
0.0005674883,
0.011893945,
-0.01329762,
-0.026093442,
-0.02926697,
-0.016016817,
-0.029728081,
0.01563708,
-0.0194209,
-0.024954228,
-0.007974504,
0.0021411134,
0.018729232,
-0.021021225,
-0.008333898,
0.04000814,
-0.012226216,
0.0017884993,
0.0012451685,
-0.17175019,
0.022024818,
0.02815488,
-0.014674171,
0.036481995,
0.003127755,
0.0016452499,
0.012477114,
-0.009561267,
0.022323184,
-0.0029972198,
0.008686513,
-0.024669424,
-0.0012638164,
-0.005496033,
0.0071675596,
0.0055095954,
0.021997694,
0.044727743,
-0.0035871703,
0.035288535,
-0.030758798,
0.0113379,
-0.024696548,
0.008096562,
-0.0042720553,
-0.01036821,
0.013033159,
-0.005685902,
0.00351936,
-0.030867295,
-0.0030633349,
0.025401777,
-0.014769105,
0.020587238,
0.0206008,
0.021590833,
-0.0119414115,
-0.013779074,
0.0035057978,
0.0022190954,
0.025076287,
0.016328745,
-0.017373025,
-0.019000474,
0.030216316,
0.024303248,
-0.019353088,
0.015854072,
-0.010341086,
0.017712077,
-0.021400962,
-0.002627653,
0.01563708,
0.013595985,
-0.010544517,
-0.011073438,
0.017956195,
-0.00018308808,
-0.015203092,
-0.018783482,
-0.008232183,
0.023353903,
-0.012558486,
-0.0033481386,
-0.043371532,
-0.023489524,
-0.016776294,
-0.0032057369,
0.0058181323,
-0.016288059,
-0.0047094324,
0.0020648267,
0.002556452,
0.006174137,
0.020872042,
0.012402522,
-0.012999254,
0.007811758,
0.006140232,
-0.006472503,
0.015623516,
-0.0044280193,
0.009032345,
0.017779887,
0.00710653,
0.004088967,
0.0024682987,
-0.0034617211,
0.0056553874,
0.0022309623,
-0.015623516,
0.008822134,
-0.015962569,
0.019393776,
0.032359123,
-0.009662982,
0.015487896,
0.0027259781,
0.0045602494,
0.008944192,
-0.004763681,
-0.030460432,
0.0348003,
0.014972537,
0.011710856,
-0.020953415,
0.006787821,
0.033742458,
-0.0019665016,
-0.019529397,
0.011222621,
0.013304401,
0.01916322,
-0.017766325,
0.036590494,
0.010096969,
-0.020872042,
-0.008238964,
-0.016803417,
0.049176104,
-0.009798603,
-0.010008816,
0.034854546,
-0.030107819,
-0.04065912,
-0.1327999,
-0.026215501,
0.001541839,
0.0103004,
-0.01584051,
0.03683461,
0.014307994,
0.0023682783,
0.0079880655,
0.011724419,
-0.010381772,
-0.014443615,
-0.008923849,
-0.011134468,
-0.005418051,
-0.0057435413,
0.02262155,
0.0088696005,
-0.033986572,
0.026690174,
-0.011229402,
0.010307181,
0.002373364,
-0.0011171764,
0.009561267,
-0.01192785,
-0.0025937478,
0.020980539,
0.00041131247,
0.00057638844,
0.019190343,
-0.0088696005,
-0.0007340476,
-0.0062351665,
-0.017427273,
0.0036109039,
0.006224995,
-0.016057502,
0.037485592,
-0.019122534,
-0.0068285074,
0.021604395,
0.010578423,
0.018525802,
0.042286567,
-0.0047297757,
-0.008591578,
0.011256527,
0.010408897,
-0.0072896183,
-0.017766325,
-0.025130535,
-0.038679052,
-0.017454397,
0.023381026,
-0.009357835,
0.014809792,
0.0046450123,
-0.009466332,
-0.015135282,
0.020614361,
0.0062589003,
-0.00045814403,
0.009527362,
-0.0013138265,
-0.011975317,
0.0025428901,
-0.035695396,
0.0014282566,
-0.03933003,
0.010354648,
-0.013345087,
-0.028290499,
-0.010090188,
-0.042069573,
0.006570828,
-0.024927104,
-0.024276124,
0.015067471,
-0.01864786,
-0.013806198,
-0.004746728,
0.018566487,
-0.013690921,
0.054004204,
0.013094189,
-0.002359802,
-0.0055841864,
0.0019376823,
-0.011175155,
0.0011849868,
0.030840172,
-0.032033633,
-0.01721028,
0.002634434,
0.038217943,
-0.023598019,
-0.02366583,
0.0004827253,
0.02548315,
-0.0076557943,
-0.019054724,
-0.051210415,
0.011188717,
0.017807012,
-0.013629891,
0.008157591,
0.0030480777,
0.0037261816,
0.0085780155,
0.024886418,
0.022974165,
-0.035288535,
0.0041635586,
0.0019614159,
-0.01421306,
-0.03127416,
-0.02235031,
0.032684613,
0.0029633145,
0.019814199,
0.002502204,
-0.008096562,
0.011846477,
-0.018634299,
0.03103004,
-0.03376958,
0.009934224,
-0.023421712,
0.0306503,
-0.019787075,
-0.014457177,
-0.00638774,
-0.0075269546,
0.003858412,
0.0037499152,
-0.022526616,
-0.0011120905,
-0.0035837798,
0.022635112,
0.003448159,
0.04315454,
0.004556859,
-0.03187089,
0.011595579,
-0.0067200107,
-0.0028751611,
-0.001395199,
-0.020248186,
0.019732827,
-0.012361837,
-0.0047433376,
0.01818675,
-0.0024428698,
-0.022011256,
-0.030324811,
-0.025469586,
0.0065470943,
0.012958568,
-0.020397369,
-0.019773513,
-0.00958161,
0.04185258,
0.026907168,
-0.0011154811,
0.013440021,
0.0043263035,
-0.015175968,
-0.0029124569,
-0.0015079338,
-0.0019173392,
-0.027408965,
-0.030406184,
-0.013507832,
0.0091611855,
0.019475147,
0.018363057,
0.00003753412,
-0.012009222,
0.02066861,
0.015175968,
0.010239371,
0.004804367,
-0.01883773,
-0.012687326,
0.009798603,
0.003331186,
-0.0029328,
0.0057265884,
0.025727266,
-0.006699668,
-0.002959924,
0.0032362514,
0.027463213,
0.005835085,
0.013826541,
0.0028599037,
0.011168373,
0.01642368,
-0.0169526,
0.009642639,
0.025347529,
-0.0010680138,
-0.0054858616,
-0.014836916,
-0.0019648063,
-0.0024004881,
0.022689361,
-0.026120568,
-0.014511426,
-0.005045094,
0.02197057,
0.01974639,
0.012687326,
0.012517801,
-0.012165186,
-0.021170408,
0.021197531,
-0.014348681,
-0.01765783,
0.00038779073,
0.0348003,
0.023028413,
0.024954228,
-0.003702448,
0.0054383944,
0.0025140706,
0.015270903,
0.022336746,
-0.033010103,
0.019366652,
-0.003787211,
0.0002561962,
0.022187563,
-0.03669899,
-0.016437242,
0.009696888,
-0.012633078,
0.024832169,
-0.0044619245,
-0.0017783277,
0.089726724,
0.010022378,
-0.009798603,
0.012856852,
-0.0032430324,
0.027856514,
0.0044754865,
-0.0027429308,
0.008320336,
-0.04556859,
0.014240185,
-0.002424222,
0.0135485185,
-0.022906354,
-0.036997356,
0.021875637,
-0.004204245,
0.018457992,
-0.005489252,
-0.018607175,
0.039547026,
0.01114803,
0.010673357,
-0.009167966,
-0.022174,
-0.005685902,
0.02502204,
0.0067437445,
0.0202075,
-0.02991795,
-0.0024411746,
-0.00651997,
-0.009005222,
-0.037919577,
0.029728081,
-0.021834949,
-0.019136095,
0.0018885197,
-0.009005222,
0.0022258766,
-0.003597342,
0.018091815,
-0.023245405,
-0.03070455,
-0.010585204,
0.008489862,
0.004770462,
-0.021238217,
-0.0141452495
] |
Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a fundamental role in metazoan development. Signals exchanged between neighboring cells through the Notch receptor can amplify and consolidate molecular differences, which eventually dictate cell fates. Thus, Notch signals control how cells respond to intrinsic or extrinsic developmental cues that are necessary to unfold specific developmental programs. Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis. | [
-0.042515535,
-0.010204259,
0.016082656,
0.008618552,
-0.0053807897,
0.020979108,
-0.02095257,
0.007437565,
-0.033200335,
-0.01141842,
0.019466383,
-0.007298235,
0.004319228,
0.009952138,
-0.00660822,
0.003020474,
0.027175972,
0.0021579554,
-0.002731862,
0.017144218,
-0.032059155,
0.019081566,
0.010834562,
-0.021417001,
-0.014251462,
0.025543822,
0.003513105,
-0.034819216,
0.011995644,
-0.016348045,
0.01377376,
0.024867076,
0.008379701,
-0.0075569907,
-0.02230606,
0.00855884,
0.0009039859,
-0.016719593,
0.012280939,
0.01459647,
0.02339416,
0.003967586,
-0.013787029,
-0.007484008,
-0.01541918,
0.007742764,
-0.005831953,
-0.0014488655,
-0.0078688245,
0.013123553,
0.019784851,
0.009434627,
-0.026857505,
-0.0037353693,
-0.009388184,
-0.005729114,
0.009388184,
0.027441364,
0.011332168,
-0.026061334,
-0.006711059,
0.008339892,
-0.0014015929,
0.011458228,
-0.015352832,
0.045089822,
-0.007948441,
0.014848591,
0.010867735,
0.019731773,
0.03054643,
0.028715236,
0.002570969,
0.018033275,
0.004345767,
-0.0093019325,
-0.024084175,
0.010648788,
-0.02176201,
0.014941477,
-0.00082229543,
-0.019439844,
-0.0050357822,
0.04485097,
0.018139431,
-0.004893135,
0.016374586,
0.025198815,
-0.006661298,
-0.0064290813,
-0.011172934,
0.016918635,
0.0044585583,
0.015127251,
-0.02393821,
0.009938869,
0.021377193,
0.018948872,
0.0098924255,
-0.018112892,
-0.01598977,
0.018935602,
-0.012473347,
-0.0050225127,
-0.01540591,
0.014808782,
-0.009109524,
-0.011517942,
0.020315632,
-0.017874042,
-0.03362496,
0.036278863,
-0.015286485,
-0.04540829,
0.025079388,
-0.003400314,
0.0028363594,
0.022611259,
-0.022597989,
0.008658361,
0.023367621,
0.021363923,
0.011226012,
-0.038720455,
0.016825749,
0.033704575,
0.009381549,
0.022398947,
-0.016586898,
-0.0025112564,
0.018033275,
-0.0048135174,
0.0012257717,
0.020328902,
-0.011630733,
0.014092228,
-0.0055698804,
-0.002818114,
-0.0054305503,
-0.016878827,
0.0071721743,
0.022120286,
-0.019691965,
0.002313872,
0.008366431,
0.013422118,
0.016918635,
0.012725468,
0.018112892,
0.007105827,
0.020514674,
0.01226767,
0.013587986,
-0.03744658,
0.012712198,
0.035349995,
-0.009481071,
0.017794423,
0.024813998,
-0.007464104,
0.00065559713,
0.0060641696,
0.010642153,
0.014530122,
0.03609309,
0.017767884,
0.009209045,
0.0055035325,
-0.0053310287,
0.0120420875,
-0.012353921,
0.0055300714,
0.006641394,
0.012081896,
-0.023672821,
-0.02725559,
0.004475145,
0.030042188,
-0.021655854,
-0.01030378,
-0.016427664,
0.009010003,
0.013641064,
0.013641064,
-0.036225785,
-0.010283876,
0.020435058,
-0.009341741,
0.00989906,
-0.008147484,
-0.0020567754,
0.011916027,
-0.0057556536,
-0.01088764,
-0.62249964,
0.0070593837,
-0.0006605732,
-0.009972042,
0.00029462477,
0.031581454,
-0.0032908404,
0.0008272715,
-0.016626706,
0.015618223,
-0.03988817,
0.01087437,
0.013309327,
-0.026937122,
-0.023049153,
-0.03219185,
-0.029644104,
-0.035668466,
0.03144876,
0.004213072,
-0.022398947,
-0.0075238165,
-0.020660639,
0.017940389,
-0.014516853,
0.018484438,
0.025450936,
-0.0012639216,
-0.0062034996,
0.020899491,
-0.013057206,
-0.025092658,
-0.00482347,
0.0022906505,
0.05642199,
0.01046965,
0.021523159,
0.026937122,
-0.010648788,
0.04217053,
-0.017953658,
-0.00069789373,
0.031740688,
0.0002913074,
-0.018683482,
-0.015857074,
0.008180657,
-0.010038391,
0.00033339663,
-0.028688697,
0.0026505862,
0.005350933,
-0.052388057,
0.010953987,
0.0018195827,
-0.021071995,
0.032032616,
-0.023022614,
0.00688688,
-0.005078908,
-0.0040272987,
0.016679784,
-0.028874472,
-0.020793336,
-0.0024084174,
0.023858594,
-0.021111803,
-0.0031382411,
0.0022491834,
0.0084858565,
0.012679025,
0.029033706,
0.0077493987,
0.0024930106,
-0.0058186837,
0.02752098,
-0.005526754,
0.011033604,
0.00784892,
0.034288436,
-0.0038846515,
-0.009726557,
-0.032006077,
0.018962141,
0.01702479,
-0.0051120818,
-0.0071124616,
0.012612677,
0.031024134,
-0.0051850644,
0.0012357238,
-0.012460077,
-0.0069996705,
-0.049415685,
-0.018391551,
0.01873656,
-0.007218618,
-0.0031697561,
-0.006389273,
-0.053847704,
-0.0058618095,
-0.032988023,
-0.009991947,
0.000815246,
0.012871432,
-0.008034693,
-0.023526855,
-0.013070475,
0.04880529,
-0.03611963,
-0.0014405721,
-0.0073579475,
-0.0085853785,
0.0033455773,
0.009826078,
-0.018670212,
0.008737978,
0.030758742,
0.016082656,
-0.0140126115,
0.009573957,
-0.01819251,
-0.004581301,
-0.011929297,
0.025835752,
0.0206341,
-0.009832713,
-0.0029806655,
-0.019439844,
-0.006170326,
-0.006906784,
-0.029617565,
0.012247765,
-0.021244498,
0.009520879,
0.00015197745,
0.0038249386,
0.002255818,
0.01405242,
-0.025849022,
-0.025849022,
0.0021612728,
0.019930815,
-0.025941908,
-0.0076366076,
-0.012897971,
-0.027096355,
0.00007417453,
0.015193598,
-0.018537516,
0.026034795,
-0.009607131,
-0.03144876,
-0.0031349235,
0.009049811,
0.007052749,
-0.0093284715,
-0.0067541846,
-0.0045746663,
-0.020700447,
-0.0063129733,
0.03171415,
-0.029007167,
-0.01017772,
-0.028157918,
-0.012805085,
0.0048732306,
0.012592773,
0.032643013,
-0.028237535,
0.012858163,
-0.0067442325,
-0.027202511,
0.0043955278,
-0.00064937706,
0.010423207,
-0.014729165,
-0.01197574,
-0.011378611,
-0.0016462496,
0.023168579,
-0.031501837,
0.0065252855,
-0.020474866,
0.028210996,
0.0096867485,
0.043948643,
0.021085264,
0.0066911546,
0.035986934,
0.00032427386,
0.0058153663,
-0.019625617,
0.024004558,
-0.0102241635,
-0.034553826,
0.03911854,
-0.0017416242,
-0.0067243283,
0.04599215,
-0.0012075262,
-0.008877307,
0.015910152,
-0.0033588468,
0.009063081,
0.012685659,
-0.0040704245,
-0.029829876,
-0.009938869,
0.01459647,
0.010688596,
0.024986502,
0.011909393,
-0.0122544,
0.01019099,
0.0015069196,
-0.011471499,
0.011498038,
-0.016892096,
-0.010681962,
0.013541543,
-0.009049811,
0.00784892,
-0.005115399,
0.002106536,
0.018457899,
0.008339892,
0.022757223,
0.002469789,
-0.018816177,
-0.017011521,
0.0005896642,
-0.012294209,
-0.004362354,
0.007702955,
0.01140515,
0.010310415,
-0.013813568,
0.032536857,
-0.0023354352,
-0.00041011104,
0.017887311,
0.013919724,
0.018643674,
0.0024399327,
-0.013070475,
0.04190514,
0.022664336,
-0.008472587,
-0.02860908,
0.010569171,
0.034606904,
-0.015193598,
-0.012944415,
0.0037652256,
-0.007079288,
0.003672339,
-0.008167388,
0.04726602,
0.007948441,
0.0058551747,
-0.007384487,
0.0035197397,
-0.012035453,
0.015538606,
0.022518372,
-0.0071390006,
-0.01403915,
-0.020421788,
0.0013460268,
-0.013574717,
-0.024309756,
0.001577414,
-0.01431781,
0.0001872246,
0.015339563,
0.016202081,
0.0017499176,
0.010449746,
0.01710441,
0.024628226,
-0.0082536405,
0.038428523,
0.02696366,
-0.028768316,
0.0055300714,
-0.04301978,
-0.008200563,
-0.008731343,
-0.011703715,
-0.0038415254,
0.015060903,
-0.023924941,
-0.015220137,
0.008565474,
-0.010934083,
-0.008054597,
-0.004040568,
0.012698929,
-0.003352212,
0.009587226,
0.0048433742,
-0.018577326,
-0.0038183038,
0.014530122,
0.009381549,
0.0023072374,
-0.020023704,
-0.021018917,
-0.028662158,
-0.00090232724,
-0.0072916,
0.010794753,
-0.045965612,
0.026592115,
0.004508319,
0.016732862,
0.0075636255,
0.0255969,
-0.009335106,
-0.014941477,
-0.024880346,
-0.0053973766,
-0.029564487,
0.031846844,
0.043046318,
0.0096204,
0.024548609,
-0.022040669,
-0.017529033,
-0.021562967,
0.0041666287,
0.013302692,
-0.04264823,
-0.00584854,
0.01792712,
0.010569171,
0.00087164144,
-0.007384487,
0.023739168,
0.01251979,
-0.0055134846,
-0.0076963203,
-0.012765276,
0.012625947,
-0.0006634759,
0.022518372,
0.023924941,
0.006060852,
-0.0027202512,
-0.000908962,
0.018763099,
0.002400124,
-0.008359796,
0.0043291803,
0.010648788,
0.012632581,
0.014078959,
-0.0047538048,
-0.020846413,
-0.013309327,
0.023341082,
-0.01459647,
0.006740915,
0.0022359139,
0.0039277775,
0.0044884146,
-0.010881005,
-0.03248378,
0.0024946693,
0.017237104,
0.008180657,
-0.022969536,
-0.010509458,
0.02368609,
-0.027600598,
0.002320507,
-0.014185115,
-0.00881096,
0.0005320247,
0.018524246,
0.0030752108,
0.009859252,
-0.028131379,
-0.0113255335,
-0.016467473,
0.017953658,
-0.027919065,
0.012533059,
-0.022372408,
-0.016666515,
-0.018617135,
-0.02012986,
0.00015062976,
0.025543822,
-0.014981286,
-0.036199246,
-0.017409608,
0.043869026,
0.041055888,
-0.005543341,
0.0077825724,
-0.0006970644,
0.03609309,
0.022438755,
-0.02863562,
-0.0084327785,
-0.016003039,
-0.00013818959,
0.009547418,
0.0116572715,
-0.021231228,
-0.008883942,
0.0049329433,
0.014211654,
-0.019758312,
0.016918635,
-0.016719593,
-0.017542303,
0.0078953635,
0.0078091114,
0.0231155,
0.0028131378,
-0.0040903287,
-0.0088441335,
-0.0007070165,
-0.02863562,
-0.02948487,
-0.017077869,
-0.03081182,
0.013395579,
0.02860908,
-0.02010332,
0.0010358518,
0.015671302,
-0.018471168,
0.0038183038,
0.002207716,
-0.0022657702,
0.023818785,
0.0102241635,
0.016958443,
-0.0022276202,
-0.007882094,
-0.0010615614,
-0.023619741,
0.010821292,
0.005619641,
-0.04766411,
0.0021679075,
-0.012413634,
-0.016852288,
-0.033916887,
0.0006141299,
-0.022239713,
0.019625617,
0.004790296,
-0.022690875,
-0.009839348,
-0.004986021,
0.0009512586,
0.0010740017,
-0.010881005,
-0.020421788,
-0.0039178254,
0.0066049024,
0.015671302,
-0.03744658,
0.019599078,
-0.042303223,
-0.013103649,
0.012174782,
0.005934792,
-0.0019025172,
-0.020819874,
0.011935932,
-0.008638456,
-0.014198384,
-0.011252551,
-0.04816835,
-0.015379371,
-0.0001771688,
0.043975182,
0.028794855,
0.015910152,
0.0075238165,
0.03333303,
-0.0011138101,
0.0068138973,
-0.0064622555,
-0.006143787,
0.019187722,
-0.014556661,
0.03988817,
-0.007318139,
-0.00007096082,
0.030626047,
0.0122544,
0.015273215,
0.0192408,
0.011159665,
-0.016494012,
-0.0012912899,
-0.030864898,
-0.015113981,
0.027441364,
0.0006108125,
0.0033024512,
-0.023606472,
0.0051552076,
0.017422877,
0.035535768,
-0.01653382,
-0.019585809,
-0.0044220667,
-0.029670643,
0.01320317,
-0.026459418,
0.008094406,
-0.021907974,
-0.0060077743,
-0.004929626,
-0.019333689,
-0.009341741,
0.00017696146,
0.026910583,
0.024906885,
-0.020342171,
-0.010363493,
0.01486186,
-0.028821394,
-0.0074773734,
0.008651726,
-0.013906455,
-0.018285396,
-0.020236015,
-0.004800248,
-0.015565145,
0.01703806,
0.011949201,
-0.016361315,
-0.009003368,
0.002154638,
-0.0012539695,
0.04076396,
-0.01267239,
0.02752098,
-0.027202511,
0.02282357,
0.005191699,
0.009613765,
-0.028662158,
-0.014530122,
-0.021788549,
0.012081896,
0.053131152,
-0.006180278,
0.0104298415,
0.00042089252,
0.018816177,
0.018378282,
-0.031953,
-0.025092658,
0.0075636255,
0.003357188,
-0.015472258,
-0.014171845,
0.0106089795,
-0.016414395,
0.004441971,
0.0015881954,
0.0007999031,
0.0049793865,
-0.02395148,
-0.01762192,
0.019041758,
0.005400694,
0.030917976,
0.014224923,
-0.006243308,
-0.013395579,
-0.02174874,
-0.0012929486,
0.0051187165,
-0.0062200865,
0.013548178,
-0.016679784,
-0.00015477648,
0.01569784,
0.027680214,
0.0062134517,
-0.018219048,
-0.014065689,
0.048592974,
0.005576515,
-0.013581351,
0.00420312,
0.0010516093,
0.004876548,
-0.024243409,
0.00038606004,
-0.017502494,
-0.031077212,
-0.0069266884,
0.030891437,
0.008930386,
0.023579933,
0.0036822911,
-0.005994505,
0.006389273,
-0.03030758,
-0.016042847,
0.0043225456,
-0.019028489,
-0.002529502,
0.000022508939,
0.007815746,
0.015910152,
0.014132037,
-0.0020916078,
-0.010330319,
0.026207298,
-0.016905366,
0.018842716,
0.010383398,
0.022053938,
-0.019957354,
0.016308237,
0.0029358808,
-0.016759401,
0.0074176607,
-0.0072517917,
-0.019718504,
0.012300843,
0.0111663,
0.02558363,
-0.012791815,
-0.014224923,
-0.00055109966,
0.015180329,
0.019612348,
0.00024403473,
-0.018590596,
0.015273215,
-0.005131986,
-0.011577655,
0.022916457,
-0.0018577325,
-0.0004424555,
-0.0039012383,
-0.013402213,
0.016494012,
-0.023487046,
-0.015565145,
-0.008061232,
-0.0020700449,
-0.01979812,
-0.011040239,
-0.033969965,
-0.015910152,
-0.023022614,
0.015658032,
-0.004939578,
-0.0044552404,
-0.0073314086,
0.00061620324,
0.009268758,
-0.0044718278,
-0.00010066173,
-0.006057535,
0.021629315,
-0.022730684,
-0.037021954,
-0.0080745015,
-0.020567752,
0.025384588,
0.023460507,
0.010516093,
-0.020514674,
0.0024183698,
-0.044585582,
-0.039675858,
-0.00921568,
-0.0017349895,
0.00991233,
0.00398749,
0.0046012052,
0.010237433,
0.0014098863,
0.010449746,
-0.0002919294,
-0.02340743,
0.0064987466,
-0.01540591,
0.011524577,
-0.0035628655,
-0.018590596,
-0.0028794855,
0.042488996,
-0.026645193,
-0.0107615795,
0.011172934,
-0.023009345,
0.022518372,
-0.01679921,
0.016056117,
0.007815746,
0.019983893,
0.015631491,
-0.015286485,
-0.0021413686,
-0.0003033329,
0.012340652,
-0.021536428,
0.018006736,
-0.018099623,
0.02696366,
0.017529033,
-0.0020186254,
-0.04511636,
0.008638456,
0.002267429,
0.01405242,
0.011491403,
-0.0052016512,
0.016653245,
0.0118629495,
0.0004333327,
-0.009209045,
-0.0038514775,
-0.006269847,
0.012884702,
-0.00080239115,
-0.007178809,
-0.017966928,
-0.0021430273,
0.001055756,
-0.040551648,
0.016467473,
0.0004897282,
0.006442351,
-0.030148344,
0.001817924,
0.0036756564,
0.0050988123,
0.009142698,
0.018006736,
-0.010005216,
-0.031820305,
-0.011624098,
0.0051883818,
-0.0024183698,
0.007981615,
-0.014065689,
0.0073911217,
0.0074972776,
0.00010947353,
-0.02339416,
-0.007623338,
0.017303452,
0.19649503,
-0.0102241635,
-0.0017515764,
-0.0020086733,
0.01459647,
-0.008645091,
-0.010091469,
0.0004756293,
-0.006435716,
-0.0016943516,
0.0044121146,
0.016984982,
-0.014092228,
0.006087391,
0.044426348,
-0.008293449,
-0.004850009,
-0.0050291475,
-0.002864557,
0.0017714807,
0.0072053485,
-0.018537516,
0.0020003798,
-0.007192079,
0.04925645,
0.002672149,
-0.038906228,
0.0027252273,
0.009985312,
0.010323685,
-0.02453534,
0.014185115,
-0.0013451974,
0.005105447,
0.0065982677,
0.010927448,
0.0017864088,
0.000887399,
0.009527514,
0.008711439,
0.019771582,
-0.014384158,
0.006356099,
-0.0062101344,
0.026923852,
-0.0028264073,
0.008698169,
-0.0011262504,
0.00591157,
-0.0034600268,
-0.030679125,
0.01953273,
0.004040568,
0.03197954,
0.0072517917,
-0.004176581,
-0.014344349,
-0.0011809871,
-0.0080745015,
0.012088531,
-0.02503958,
-0.0028728507,
-0.0096204,
-0.0032858644,
-0.021231228,
0.026884044,
-0.02340743,
0.0018676847,
0.0075304513,
-0.01843136,
-0.011949201,
-0.0064224466,
-0.012181417,
-0.019161183,
-0.009016638,
-0.024057636,
0.036995415,
0.0011503013,
0.027919065,
0.030891437,
0.029299095,
0.009978677,
-0.03001565,
0.0011420079,
0.00022765517,
-0.03410266,
0.040392414,
-0.009116159,
-0.020992378,
-0.0022375726,
0.012015549,
-0.015671302,
-0.013879916,
-0.022438755,
-0.0019987212,
-0.008572109,
-0.00148121,
0.012287574,
-0.0220274,
0.009726557,
-0.025941908,
0.060986705,
0.006986401,
0.010774849,
-0.0206341,
0.016281698,
0.0051817466,
0.015220137,
0.025729595,
-0.000032810956,
-0.00056353986,
-0.01115303,
0.0043855757,
-0.017436147,
-0.0025212085,
0.021961052,
0.013866646,
-0.023765707,
0.043152474,
-0.022359138,
-0.01653382,
-0.032059155,
-0.006040948,
0.045010205,
-0.0088441335,
0.004896452,
0.0017996784,
0.009467801,
0.010270607,
-0.020209476,
0.0006916736,
-0.023540124,
-0.0022060573,
-0.0023453874,
0.015167059,
-0.027282128,
0.009248854,
-0.027361747,
-0.02615422,
0.029007167,
-0.02039525,
0.018457899,
0.016507281,
0.02722905,
0.010502824,
-0.008386335,
0.020594291,
0.022067208,
-0.011843045,
-0.023805516,
-0.0035595482,
-0.0033406012,
-0.006933323,
-0.007736129,
0.020209476,
-0.01953273,
-0.016188812,
-0.01819251,
0.014968016,
-0.018763099,
-0.030732203,
-0.0067807236,
-0.0032759123,
-0.027414825,
0.000289234,
0.010336954,
-0.16475433,
0.028980628,
0.00784892,
-0.009341741,
0.026485957,
0.016759401,
-0.018909063,
0.008625187,
0.009275393,
0.01540591,
0.03192646,
0.0060177264,
-0.021589506,
-0.027839448,
0.012844893,
0.025769403,
0.009023272,
0.030440275,
-0.00839297,
0.024813998,
0.023619741,
-0.017170757,
0.030652586,
0.0015964889,
0.005944744,
-0.010914179,
0.010091469,
-0.014649548,
0.008837499,
-0.009228949,
-0.0076432424,
-0.012765276,
0.00879769,
0.009235584,
0.029060245,
0.0066745677,
0.00072733546,
-0.012732103,
-0.005593102,
0.016905366,
0.007875459,
0.040073946,
-0.01762192,
0.0065717287,
-0.015764188,
0.03545615,
-0.00036325306,
-0.0105824405,
0.010814657,
-0.022438755,
0.025994986,
0.0013252931,
-0.018922333,
0.023765707,
0.040127024,
0.0089436555,
-0.009474436,
0.021390462,
-0.0053476156,
-0.020965839,
0.01006493,
-0.0070394794,
0.008160753,
0.015286485,
0.00063983956,
-0.0081010405,
-0.014994555,
0.021549698,
-0.04742526,
0.009069716,
0.003181367,
-0.0007364582,
0.018882524,
-0.027069816,
0.02449553,
0.02338089,
0.010668692,
0.010204259,
-0.012824989,
0.004816835,
-0.0046907747,
0.009262123,
0.0031199954,
-0.030095266,
-0.01703806,
-0.012513155,
0.007921902,
0.035137683,
0.009520879,
-0.0022591355,
0.01182314,
-0.014822052,
0.009023272,
-0.027414825,
0.02502631,
0.023367621,
-0.0005867615,
-0.01250652,
-0.015167059,
-0.0068470715,
0.028980628,
-0.012486616,
0.015750919,
-0.0055632456,
0.014516853,
0.0026638557,
-0.012990858,
0.0071655395,
0.057112005,
-0.00082810083,
-0.0008907164,
-0.020474866,
0.013183266,
-0.018205779,
-0.013840107,
0.051114183,
0.00196223,
0.003020474,
0.0050722733,
-0.015100712,
0.07871478,
0.011644002,
-0.00978627,
0.017237104,
-0.01431781,
-0.041533593,
-0.1539264,
-0.016348045,
0.0055798325,
0.031050673,
0.0019904277,
0.0067608193,
-0.002075021,
0.011206108,
-0.003977538,
0.037021954,
-0.038163133,
-0.009182506,
-0.021377193,
-0.019745043,
-0.015167059,
-0.0053277113,
0.024893615,
-0.018112892,
-0.026910583,
0.03988817,
-0.011829776,
-0.03604001,
-0.015631491,
0.0054139635,
0.0027849402,
0.0017233787,
-0.027175972,
-0.002929246,
0.0031830256,
-0.007099192,
0.01431781,
-0.0033074273,
0.040578187,
-0.013269518,
-0.03081182,
-0.0159765,
0.00770959,
-0.025543822,
0.03054643,
-0.008804325,
0.010151181,
0.01377376,
0.0063494644,
-0.017568842,
-0.0037917648,
-0.011909393,
-0.009573957,
0.0159765,
0.005281268,
-0.004372306,
-0.0324307,
-0.028874472,
-0.036146168,
-0.021217959,
0.0095606875,
-0.00881096,
-0.0067243283,
0.02150989,
-0.014370888,
0.0026754665,
-0.010741675,
0.016958443,
-0.018351743,
-0.012752007,
0.032377623,
-0.014729165,
-0.028025223,
-0.027282128,
0.03550923,
-0.0120420875,
0.0006742574,
0.01762192,
-0.0038415254,
0.026830966,
-0.013574717,
0.014662817,
-0.018869255,
-0.009627035,
-0.013747221,
-0.014530122,
-0.0078091114,
-0.01265912,
0.02064737,
-0.010330319,
0.0220274,
0.01926734,
-0.0054604067,
0.003609309,
0.0011801578,
-0.011955836,
-0.0073712175,
0.030758742,
0.018378282,
0.0043291803,
-0.015180329,
0.0054504545,
0.0037386867,
-0.0056760362,
-0.0037619083,
0.007052749,
-0.009739826,
-0.0002347046,
-0.038348906,
0.017157488,
-0.03001565,
0.00468414,
0.022080477,
-0.0386143,
-0.005656132,
-0.034394592,
0.0019738409,
0.017582111,
-0.015936691,
0.019081566,
0.004986021,
-0.015379371,
-0.040684342,
-0.0118364105,
0.025928639,
-0.0084593175,
-0.002864557,
0.024362834,
0.022677606,
-0.039675858,
0.034288436,
-0.0046376963,
0.0047538048,
-0.019665426,
-0.014623009,
-0.0091758715,
-0.0008923751,
0.002705323,
0.004518271,
-0.031369142,
0.016878827,
0.010681962,
-0.025424397,
-0.007623338,
-0.027680214,
0.03221839,
0.024694573,
0.035349995,
-0.0036225785,
-0.03144876,
0.005141938,
-0.012625947,
-0.012990858,
0.008193928,
-0.033253413,
-0.0049594822,
-0.0012473346,
-0.019944085,
0.03911854,
0.010356858,
-0.014981286,
-0.019970624,
-0.0111663,
-0.0098658865,
-0.009374915,
-0.018696751,
-0.019108105,
-0.038375445,
0.018006736,
0.02615422,
0.014384158,
-0.0096602095,
0.0053210766,
-0.020036973,
-0.024840537,
0.009600496,
0.012513155,
-0.0100450255,
-0.026485957,
-0.022717414,
0.00935501,
-0.0051618423,
-0.0020766796,
-0.010662057,
-0.021788549,
-0.019957354,
-0.028741775,
0.014742435,
0.025955178,
0.011172934,
-0.024614956,
0.011730254,
0.045832913,
-0.0053973766,
-0.027653676,
0.01711768,
-0.0020567754,
-0.01238046,
-0.0091758715,
0.028025223,
0.014808782,
0.012493251,
0.0050490517,
0.021098534,
-0.011219378,
0.03768543,
-0.008917117,
0.007464104,
-0.008903846,
0.0076631466,
0.01100043,
-0.016082656,
0.0056859883,
0.021151612,
-0.027653676,
-0.047451798,
-0.0025792625,
-0.0025825799,
0.016945174,
0.0018909064,
0.005344298,
-0.002950809,
-0.028264074,
0.01816597,
0.005997822,
-0.0053011724,
-0.013468561,
0.022465294,
0.009905695,
0.0026223885,
-0.00034604414,
-0.0064025423,
-0.0016296627,
-0.012446808,
0.012327382,
0.00045945705,
0.015113981,
-0.006336195,
0.0072517917,
0.009122794,
-0.006133835,
-0.016003039,
0.00047438528,
-0.009374915,
0.007484008,
0.009580592,
-0.031342603,
0.07924556,
-0.0056262757,
-0.0068072625,
0.0001898163,
-0.012327382,
0.045010205,
0.0019987212,
0.022080477,
-0.02837023,
-0.03144876,
0.03330649,
-0.0107350405,
0.04325863,
-0.018776368,
-0.00086003065,
0.017688267,
-0.014835321,
0.003742004,
0.017396338,
0.0041732634,
0.0037552735,
-0.017223835,
-0.022199905,
0.006860341,
-0.035084605,
-0.0016296627,
0.012181417,
0.0024150524,
-0.018457899,
-0.006170326,
-0.004850009,
0.013893185,
-0.033704575,
0.0007227741,
-0.0136543345,
-0.00084302906,
-0.022478564,
-0.022876648,
-0.008990099,
0.031554915,
-0.017940389,
0.0038050343,
-0.015790727,
-0.021907974,
0.007158905,
0.0091758715,
0.0063793208,
-0.0032593254,
-0.031209907
] |
Increasing evidence suggests long non-coding RNAs (lncRNAs) are frequently aberrantly expressed in cancers, however, few related lncRNA signatures have been established for prediction of cancer prognosis. We aimed to develop a lncRNA signature to improve prognosis prediction of colorectal cancer (CRC). Using a lncRNA-mining approach, we performed lncRNA expression profiling in large CRC cohorts from Gene Expression Ominus (GEO), including GSE39582 test series(N=436), internal validation series (N=117); and two independent validation series GSE14333 (N=197) and GSE17536(N | [
-0.009596755,
-0.0008644136,
0.016491903,
-0.029059082,
-0.006801062,
-0.011579278,
-0.021008022,
0.021155871,
-0.0357795,
0.015040292,
0.011344063,
0.012540298,
-0.0064919223,
-0.0025201563,
-0.012600781,
0.016263409,
0.024583284,
-0.010040303,
0.020618238,
-0.0005191522,
-0.025497261,
0.018763404,
-0.011760729,
-0.027688118,
0.007708318,
0.0007022835,
0.012217717,
-0.034973048,
0.02143813,
-0.026034893,
0.020698883,
-0.0006468401,
-0.014274165,
-0.029731123,
-0.027056398,
0.0015314149,
0.010167991,
-0.0055510644,
0.012943523,
-0.01852147,
0.013434113,
0.0080645,
-0.008595413,
-0.02176071,
-0.0015456958,
-0.014448896,
0.023037588,
-0.027634354,
-0.006737218,
0.03180101,
0.0012558779,
-0.00086609373,
-0.025188122,
-0.019327918,
-0.0005821561,
0.0020547675,
0.014973088,
0.036155842,
-0.011061806,
-0.0071975663,
0.006807782,
-0.0008030898,
-0.021384366,
0.010504011,
-0.016585989,
0.005947569,
-0.012936803,
0.0025755996,
0.00306619,
0.0002143183,
0.026801022,
0.020241896,
-0.009240573,
0.02579296,
0.022620922,
-0.020766087,
-0.02935478,
0.00005273952,
0.00886423,
-0.007688157,
0.007876328,
0.017822545,
-0.001790991,
0.0074462215,
0.020188132,
0.013098092,
-0.010094066,
-0.0015129338,
-0.018333297,
-0.00077662815,
0.028467685,
0.039139707,
0.02224458,
0.0125739,
-0.009946217,
-0.019475767,
-0.00983197,
0.03499993,
-0.0054233763,
-0.052795593,
-0.020094046,
0.016653193,
-0.0068951477,
-0.0013130014,
-0.032204237,
0.0015566165,
0.014206961,
-0.011518794,
0.03486552,
-0.0026864866,
-0.01837362,
0.03352144,
0.0047815763,
-0.008494607,
0.03384402,
-0.013595403,
0.014556423,
-0.005756037,
-0.013494597,
-0.015537604,
0.006112219,
0.01772846,
0.0018245932,
-0.03209671,
0.005853483,
0.012352126,
-0.010504011,
0.008192188,
0.0016742238,
0.0039885673,
0.008965036,
0.0009467387,
0.01289648,
0.021518774,
-0.019274155,
0.0048353397,
0.0006304591,
-0.013723091,
-0.023682749,
-0.015376314,
-0.013595403,
0.04303755,
-0.014556423,
-0.0026377635,
-0.013817177,
-0.012311803,
0.02224458,
0.0024092693,
0.022526836,
-0.004126336,
0.0064213583,
-0.007721759,
0.01210347,
-0.00209677,
-0.0058602034,
0.0046370877,
0.013239221,
0.022526836,
-0.025497261,
-0.027056398,
0.0029805049,
0.0027066479,
0.012762072,
0.03338703,
0.0017389078,
0.025268767,
0.014301047,
0.005178081,
-0.0047849366,
-0.008192188,
0.009314498,
0.025752638,
-0.038924653,
0.020672001,
0.00082199095,
0.008434123,
-0.012479814,
0.016693516,
-0.01692201,
-0.013669328,
-0.008030898,
0.028897792,
0.009327939,
-0.01645158,
-0.023239201,
-0.0116196005,
0.03223112,
-0.004613566,
-0.002337025,
-0.020887055,
-0.010470409,
0.002839376,
0.02208329,
0.0076007913,
-0.6262353,
-0.04225798,
0.007950253,
-0.015577926,
0.018104803,
0.01548384,
0.001709506,
-0.016572548,
-0.030940799,
0.030214993,
-0.029166609,
-0.0009879012,
0.019596735,
-0.008185468,
-0.0066028093,
-0.042930022,
-0.0056686713,
0.0030057065,
0.040188093,
0.008185468,
-0.028655857,
0.014731154,
0.033091333,
0.0039314437,
-0.014986529,
0.011216375,
0.001967402,
-0.015134378,
0.0022378988,
0.016330613,
-0.026411237,
0.005678752,
-0.020712323,
-0.019878993,
0.049784847,
-0.026747258,
-0.0008467725,
0.0011592719,
0.014973088,
0.030752627,
-0.007641114,
-0.007936812,
0.018010717,
0.0115725575,
-0.043467656,
0.004469077,
-0.013360188,
0.009946217,
-0.00032993045,
-0.021061786,
-0.016720397,
0.016034914,
-0.020013401,
-0.018844048,
-0.01548384,
-0.010026862,
0.0357795,
-0.03948917,
0.008696219,
0.0022328584,
-0.0054905806,
0.011417988,
-0.020698883,
-0.031881656,
-0.00087869447,
0.028897792,
-0.011868256,
-0.017661255,
0.007547028,
0.027123602,
0.0084677255,
0.036344014,
0.012298362,
0.003595423,
0.009260735,
0.04645152,
-0.0005015111,
0.018104803,
0.011411267,
0.001226476,
0.016048355,
0.005977811,
-0.028924674,
0.013091371,
0.01596771,
0.001692705,
-0.017553728,
-0.0052352045,
0.0058434024,
0.017486524,
0.011471751,
-0.0020026842,
0.003306445,
-0.025497261,
0.010188152,
0.009455626,
-0.015900506,
0.014314488,
0.028091341,
-0.027513387,
-0.020403186,
-0.014650509,
0.013749973,
-0.020483831,
0.0017069859,
-0.018400501,
-0.0040893736,
-0.0008341717,
0.0267607,
-0.01838706,
-0.009583314,
-0.004321228,
-0.0013928064,
-0.010181432,
-0.0027301693,
-0.017137062,
-0.0016103799,
0.014919325,
-0.005903886,
-0.025430057,
0.008413962,
0.0054300968,
-0.005500661,
-0.0030409885,
0.01821233,
-0.019637058,
0.005678752,
-0.004092734,
0.015685452,
-0.02145157,
0.0044556363,
-0.031344023,
0.0063306326,
-0.012728469,
-0.011639762,
-0.020725764,
0.007614232,
0.0094018625,
-0.0014280885,
-0.028790265,
-0.031021444,
-0.0001402887,
0.015416636,
0.0010105827,
-0.0021135712,
-0.004727813,
-0.03190854,
0.0033148455,
0.00018617655,
0.021209635,
-0.0080241775,
-0.021169312,
-0.0021874956,
0.008172027,
-0.008602133,
-0.00057291554,
-0.011633041,
-0.0117472885,
0.008891111,
-0.020483831,
-0.003837358,
0.013474436,
-0.012782233,
-0.01210347,
0.003854159,
-0.009663959,
0.00886423,
0.037338637,
0.0055040214,
-0.023131674,
0.0030023463,
-0.016102118,
0.01565857,
0.009872292,
0.006696895,
0.000101751306,
-0.027352097,
0.008857509,
0.0018296335,
-0.010692183,
0.016075237,
0.0021286919,
-0.018494587,
-0.01225804,
0.017284911,
0.04583324,
0.043817118,
-0.0038944816,
0.000871134,
0.0026730457,
-0.034784876,
0.002513436,
-0.022271462,
0.030564455,
0.000028509268,
-0.010456968,
-0.014220402,
-0.008346758,
0.018454265,
0.01388438,
0.0045833243,
-0.010376323,
-0.0047345334,
-0.00041834594,
-0.002288302,
0.00548386,
0.02401877,
-0.008172027,
0.0042002606,
-0.009966378,
0.014381692,
0.0012113551,
-0.0067607393,
-0.010006701,
-0.0037029495,
0.020430068,
-0.005635069,
0.004932786,
0.0028679378,
-0.017069858,
-0.007036276,
0.013266102,
0.0018094722,
-0.0035752617,
-0.008165306,
0.0045833243,
-0.0018951575,
0.00063717953,
0.0059542893,
-0.009966378,
-0.008662617,
0.02499995,
0.0044791577,
0.0031384346,
0.024274144,
0.01063842,
0.010739226,
-0.020766087,
0.017016094,
0.0041700187,
-0.03177413,
0.0048924633,
-0.0012541978,
0.0007913291,
0.017715018,
-0.026585968,
0.026276829,
0.031693485,
-0.010624979,
0.0094489055,
-0.006989233,
0.023965007,
-0.029973058,
0.010866914,
0.004206981,
-0.040403146,
0.009408583,
0.012701588,
0.066666536,
0.024973068,
0.008508047,
0.014247283,
-0.0020816491,
-0.02645156,
-0.0042271423,
-0.009388423,
0.026384356,
0.00054141355,
-0.005272167,
0.012486534,
-0.013192178,
-0.031021444,
0.013817177,
-0.0373924,
0.00338541,
0.026088657,
0.01887093,
0.03290316,
0.019811789,
0.0044892384,
-0.0064045573,
-0.012983845,
0.03967734,
0.024408553,
-0.024717692,
-0.03948917,
-0.031854775,
0.011498633,
-0.013763414,
0.0011743928,
0.01838706,
0.02693543,
0.0076343934,
0.0035584606,
-0.00024655528,
0.008682778,
0.021236517,
-0.017916631,
0.01049057,
-0.0010147829,
0.014045671,
-0.0042103413,
0.0073790173,
-0.0071706846,
0.048091304,
0.009865572,
-0.018333297,
0.015349432,
-0.010786269,
-0.010033582,
-0.019542972,
-0.0030947519,
0.015792979,
-0.016129,
0.0069489107,
0.0011743928,
0.013077931,
-0.011727127,
0.0072311684,
0.022163935,
-0.0050873556,
-0.03470423,
-0.013427393,
0.028602093,
0.024663929,
0.01611556,
-0.007970414,
0.01548384,
0.019220391,
-0.0110819675,
-0.026276829,
-0.031182734,
0.014139757,
-0.009529551,
-0.024059093,
0.014905884,
-0.013924703,
0.02176071,
-0.007802404,
0.016827924,
0.0066498523,
-0.036881648,
-0.02176071,
0.0029805049,
-0.008178747,
0.012029546,
0.0251478,
0.037311755,
0.021841355,
-0.025873605,
0.012667986,
0.012614222,
0.02081985,
-0.02645156,
-0.0030695503,
0.017163943,
-0.002998986,
-0.0015011731,
0.006145821,
0.013575242,
0.026868226,
0.011229816,
0.009267455,
-0.013844059,
0.037795622,
0.011599439,
0.03080639,
0.003884401,
0.0100201415,
-0.0049563074,
-0.018306416,
0.029220372,
0.0027184086,
-0.0057190745,
0.004075933,
-0.0097983675,
0.0074462215,
-0.01307121,
0.026169302,
-0.0047714957,
-0.0135685215,
0.0051713604,
0.014610186,
-0.014892443,
0.0039952877,
-0.022204258,
0.007755361,
0.008534929,
-0.013830618,
-0.017809104,
-0.02208329,
-0.009106165,
-0.006095418,
-0.011075247,
-0.0007547868,
-0.0102889575,
-0.010698903,
0.021666624,
0.017056417,
0.026720377,
0.014744595,
-0.012184115,
0.014771475,
0.017567169,
0.009267455,
-0.022983825,
-0.0020917298,
-0.018279534,
0.0106854625,
-0.021585979,
-0.0029469028,
-0.007237889,
-0.037688095,
0.013978466,
-0.0051747207,
0.004640448,
0.020833291,
-0.0010366243,
-0.005339371,
0.004902544,
0.01160616,
0.00021106309,
0.007237889,
0.003051069,
0.012916641,
-0.017553728,
-0.032365527,
-0.016155882,
-0.012231158,
-0.025591347,
0.001644822,
0.016384376,
-0.0128091145,
-0.015053733,
0.023628986,
-0.026814463,
-0.0014188479,
0.03793003,
-0.0062936703,
0.013817177,
-0.02887091,
0.010443527,
0.0052385647,
-0.010887075,
-0.017029535,
0.0070900396,
0.0041061747,
-0.005792999,
-0.0053763334,
0.012560459,
-0.012715029,
-0.013622285,
-0.032365527,
-0.032311764,
-0.021827914,
0.04446228,
-0.0043514697,
-0.012923362,
-0.008427403,
-0.002839376,
0.014542982,
-0.0054233763,
-0.009247294,
-0.0290322,
-0.025551025,
0.008857509,
0.021639742,
-0.024596725,
0.02708328,
-0.025846723,
-0.010692183,
0.021532215,
0.015887065,
-0.0041028145,
0.0026260028,
0.002451272,
-0.0325537,
-0.019878993,
0.013158576,
-0.0044892384,
0.0064381594,
0.01160616,
0.043790236,
0.018091362,
0.033897784,
0.008212349,
0.014973088,
0.019852111,
0.017809104,
-0.01338707,
-0.021357484,
0.008931434,
-0.010013421,
-0.007157244,
0.017029535,
-0.022217698,
-0.008077941,
-0.015685452,
-0.0072042868,
-0.008608853,
-0.02579296,
-0.009052401,
0.0053931344,
-0.033467676,
-0.074838564,
0.007889769,
0.00790321,
0.018911252,
-0.028924674,
0.0021169314,
0.028978437,
0.0065860082,
0.023131674,
-0.024395112,
0.015672011,
0.011364224,
0.017029535,
-0.005577946,
0.007956973,
-0.011585998,
-0.007392458,
-0.019637058,
-0.0052654464,
-0.009106165,
-0.013004006,
0.025846723,
0.019166628,
-0.015255346,
0.007641114,
0.0023773473,
-0.046881627,
0.00033833098,
0.0012709989,
-0.028037578,
0.0005926567,
-0.008319876,
-0.009952937,
-0.0325537,
0.0074462215,
0.0052990485,
0.006256708,
0.02337361,
0.0011357504,
-0.028010696,
0.01983867,
0.005934128,
0.007338695,
-0.015201583,
0.010409925,
-0.0047647753,
-0.0024899144,
-0.032661226,
0.004388432,
0.00032342004,
-0.019731143,
0.017943513,
0.013749973,
-0.013084651,
-0.00661625,
0.020430068,
0.010208313,
-0.013729812,
-0.035214983,
0.025174681,
-0.01645158,
0.025241885,
-0.023723071,
-0.00085391296,
-0.036236487,
0.012358846,
-0.014005348,
0.0016498623,
-0.0022345386,
0.0023975086,
0.010779548,
0.015268787,
-0.026868226,
0.022056408,
-0.02014781,
-0.020201573,
-0.019126305,
-0.008306435,
0.0029099404,
-0.0019724423,
-0.006145821,
0.0274193,
-0.003951605,
0.0023084632,
0.018494587,
0.0035114177,
-0.010436807,
-0.0039784866,
-0.010611538,
0.045214962,
-0.029811768,
-0.016209645,
0.010430086,
0.021370925,
-0.0051209577,
0.015335991,
-0.001886757,
-0.018803725,
-0.03932788,
-0.0060618157,
0.038118202,
0.009563153,
-0.0046841307,
-0.01210347,
-0.00145077,
0.014650509,
-0.03180101,
-0.020483831,
0.0012340365,
-0.038440783,
-0.010987882,
-0.006801062,
0.034623586,
0.041236475,
0.025094036,
-0.006737218,
-0.020362863,
0.034973048,
-0.0144085735,
0.010658581,
-0.003595423,
-0.026088657,
-0.009563153,
0.039381642,
-0.00225806,
-0.028145105,
0.020927377,
-0.033467676,
-0.025739197,
0.0017137063,
0.0021673343,
0.0131720165,
0.018319856,
-0.01548384,
0.0044724373,
0.027378978,
-0.005137759,
0.0074327807,
-0.016249968,
0.011874977,
-0.03408595,
0.009563153,
0.0044623567,
0.01659943,
0.012022826,
-0.023776835,
-0.004559803,
0.017352115,
-0.0069220294,
-0.022835976,
-0.00083627185,
0.017177384,
-0.0042708246,
-0.0011466711,
-0.0026696855,
-0.0015381353,
-0.006901868,
0.011310461,
0.0022311783,
-0.011733848,
-0.006579288,
-0.0023185438,
0.010947559,
0.022634363,
-0.012661265,
-0.015403195,
-0.0022647805,
-0.005420016,
-0.034973048,
0.014368251,
-0.0319623,
0.024905864,
0.007594071,
-0.021733828,
-0.04110207,
-0.017674696,
-0.036720358,
-0.03209671,
0.020483831,
0.016653193,
0.0017758701,
0.017567169,
0.008084661,
0.02951607,
-0.013434113,
0.00677418,
0.009166649,
-0.01967738,
0.012063148,
0.0042338627,
0.007936812,
0.0070295557,
-0.01936824,
-0.0066196104,
0.026344033,
0.03422036,
-0.041532174,
0.024421994,
-0.011028204,
0.015725775,
-0.02290318,
-0.009321218,
-0.0035551004,
0.0152956685,
0.021801032,
-0.029946176,
-0.012956964,
0.0058770045,
0.0047815763,
-0.004640448,
0.022042967,
-0.019408563,
0.032768752,
-0.0022042966,
-0.0075268666,
-0.040214974,
0.021626301,
0.00418682,
-0.008917993,
0.03723111,
0.021868236,
0.03967734,
-0.0048151785,
0.004092734,
-0.03486552,
-0.032473054,
-0.010987882,
-0.0012373967,
0.009233853,
-0.010712344,
-0.02598113,
0.002530237,
-0.0093077775,
0.0033568481,
-0.013776855,
-0.012063148,
-0.020335982,
-0.0041800993,
0.0044455556,
-0.0062466273,
-0.01982523,
0.005850123,
0.024596725,
-0.040510673,
-0.014892443,
-0.013494597,
-0.023575222,
-0.035268746,
0.009879013,
-0.017378997,
0.010739226,
-0.011404547,
-0.007163964,
-0.020040283,
-0.006011413,
0.010544334,
0.19376305,
-0.026989194,
0.0050974363,
0.0063138315,
0.01419352,
-0.0038642397,
0.02337361,
0.015134378,
-0.013924703,
0.010940839,
0.035376273,
-0.00903224,
-0.008991918,
-0.0021152513,
0.031075208,
-0.017217707,
-0.026411237,
-0.020416627,
-0.015215023,
0.009637077,
-0.002710008,
-0.008044339,
-0.0010357843,
-0.022970384,
-0.0023807075,
-0.011874977,
-0.009737884,
0.0003482016,
0.011982503,
0.010974441,
-0.042822495,
0.0025856802,
-0.0051915217,
0.00419018,
-0.004469077,
0.020779528,
0.02822575,
0.0030863513,
-0.012345405,
-0.0062029446,
0.010611538,
-0.002032926,
-0.006102138,
-0.020134369,
0.022123612,
-0.0040893736,
-0.0051915217,
0.0012634384,
0.006502003,
0.00095261907,
-0.040107448,
0.019717703,
0.018185448,
0.019583294,
-0.0036995893,
0.004327948,
-0.005776198,
-0.016720397,
-0.0033652487,
0.03349456,
0.0026428038,
-0.0009685801,
-0.0011794331,
-0.0015314149,
-0.03338703,
0.046075176,
-0.0047378936,
0.004374991,
0.0014339689,
0.0022479794,
-0.014287606,
-0.013649167,
-0.008776864,
0.0043951524,
-0.029919295,
-0.018185448,
0.03499993,
0.012479814,
0.0119220195,
0.03736552,
0.02564511,
-0.0015582966,
-0.034731112,
-0.0058165207,
-0.008252672,
-0.021384366,
0.0049865493,
0.014274165,
-0.015752656,
-0.016639752,
0.019112865,
-0.018198889,
-0.013629005,
-0.010060464,
0.024435434,
0.019637058,
-0.017405879,
0.0038642397,
-0.01176745,
-0.022983825,
-0.04693539,
0.079892315,
-0.00034442137,
0.029381663,
-0.022889739,
0.0043615503,
-0.008487887,
0.005920687,
0.023763394,
0.0007774682,
0.0037768742,
-0.021908559,
0.016948892,
-0.019327918,
0.012325244,
0.023158556,
0.044220343,
-0.021505333,
0.02338705,
-0.005866924,
-0.011370945,
-0.032311764,
-0.000093875824,
0.031263378,
-0.0068279435,
0.0027469704,
0.0040860134,
-0.009489228,
-0.0004985709,
-0.025430057,
0.011881697,
-0.005463699,
0.003918003,
-0.009388423,
-0.0040255296,
-0.018978456,
0.006381036,
-0.017768782,
-0.008649176,
-0.026411237,
-0.010719065,
0.004203621,
-0.007708318,
-0.0012592381,
-0.019596735,
0.02145157,
0.016048355,
0.0054132957,
0.0044757975,
-0.007486544,
-0.00661289,
-0.016155882,
-0.009045681,
0.026706936,
0.02967736,
-0.017231148,
-0.031693485,
-0.01775534,
0.0027133683,
0.016465021,
-0.034650467,
-0.0019337999,
0.018145125,
-0.016155882,
-0.00532593,
0.004062492,
-0.16967708,
0.026209624,
0.005241925,
-0.04075261,
0.006048375,
0.0193548,
-0.016263409,
-0.0069489107,
0.0060584554,
0.009361541,
0.019247273,
-0.018010717,
-0.05435473,
-0.018413942,
0.001436489,
0.008252672,
-0.009899174,
0.017916631,
0.032499935,
0.025860164,
0.020403186,
-0.021115549,
0.002179095,
0.0031350744,
-0.016827924,
-0.014206961,
-0.0057963594,
-0.018817166,
-0.016948892,
-0.012533577,
-0.008749982,
0.0094018625,
0.009166649,
-0.014368251,
0.0055040214,
0.015349432,
-0.029811768,
-0.0029469028,
-0.011431429,
-0.0101948725,
0.018440824,
0.046048295,
0.009966378,
0.010557774,
-0.013608844,
0.022782212,
0.028494567,
-0.014986529,
0.023508018,
0.006434799,
0.006384396,
-0.032177355,
0.028279513,
0.0030712304,
-0.00018449644,
0.030725745,
0.005063834,
0.007977135,
-0.010235195,
-0.021061786,
-0.01564513,
-0.03438165,
0.016411258,
0.016075237,
0.013037608,
-0.0132997045,
-0.015335991,
0.015040292,
-0.011055086,
0.006260068,
-0.019811789,
-0.011256698,
0.0036357455,
-0.013010726,
0.042795613,
0.0051747207,
-0.020860173,
0.02612898,
-0.004731173,
-0.017983835,
-0.007163964,
-0.00091481674,
-0.024784897,
-0.008037618,
0.028467685,
-0.010745946,
0.020792969,
0.010900516,
-0.010920677,
-0.01676072,
0.042311743,
-0.004290986,
0.0117472885,
-0.0128561575,
0.007271491,
0.020107487,
0.00094421854,
-0.0021270118,
-0.001985883,
-0.026465,
0.029274136,
-0.012291642,
-0.017795663,
0.014529541,
0.024717692,
0.016827924,
-0.005356172,
-0.014112875,
0.04432787,
-0.014865561,
-0.005561145,
0.0003918843,
0.01483868,
0.017553728,
0.00019027179,
0.032634344,
-0.023427373,
-0.010120948,
0.0019707622,
-0.027204247,
0.038306374,
-0.017298352,
0.006085337,
-0.0033014046,
0.0054435376,
-0.019072542,
-0.11483848,
-0.017056417,
0.012553738,
0.007990575,
-0.026585968,
0.046021413,
-0.0042137015,
0.015349432,
-0.050188072,
0.051075168,
-0.00005423586,
0.003371969,
-0.008924713,
0.0065927287,
0.0017523486,
-0.004979829,
-0.014690831,
-0.023292964,
0.0007661275,
0.028306395,
0.01209675,
-0.0020900497,
0.024462316,
-0.018857488,
0.010033582,
-0.011740568,
-0.020631678,
0.010026862,
0.024663929,
0.010295678,
-0.0028931394,
-0.008292994,
0.010403205,
-0.0032644423,
-0.046075176,
0.0015658571,
-0.016585989,
-0.026908549,
0.029569833,
0.010524172,
0.015551045,
0.016975773,
-0.004821899,
0.014811798,
-0.008897832,
-0.004983189,
-0.009583314,
0.026989194,
0.021653183,
-0.014905884,
-0.007842726,
-0.028951555,
-0.027432742,
-0.0048118182,
0.022056408,
-0.023454254,
0.021236517,
0.036881648,
-0.0045564426,
-0.009482508,
-0.0058098002,
0.002659605,
-0.030053703,
0.01838706,
0.011915299,
0.00038306374,
0.013037608,
-0.0044623567,
0.009012079,
-0.029274136,
-0.011169333,
0.004657249,
-0.008588692,
-0.011391106,
-0.011599439,
0.01338707,
-0.014206961,
-0.029784886,
0.017956953,
-0.00999998,
-0.0076814364,
-0.024878982,
0.014139757,
-0.03997304,
0.023279523,
0.009301057,
-0.0007917491,
-0.023171997,
0.005994612,
-0.012137072,
0.010073905,
0.05481172,
-0.008279554,
-0.010705624,
-0.0064717615,
-0.0025251966,
-0.0029754646,
-0.0046942113,
0.006350794,
0.00084887265,
0.003321566,
-0.00078166847,
-0.06499987,
0.006807782,
-0.004260744,
-0.018198889,
0.01516126,
-0.033602085,
0.015094056,
-0.00934138,
0.0011088687,
0.022835976,
-0.005077275,
0.0054267365,
-0.012063148,
-0.0033921304,
-0.0055678654,
0.00015708974,
0.01581986,
-0.000118762364,
0.03806444,
0.04661281,
0.0067674597,
0.0020278858,
-0.0035685413,
-0.0027923333,
-0.015268787,
-0.017392438,
0.0030393084,
0.021720387,
-0.022983825,
-0.03596767,
0.0076814364,
-0.012130352,
-0.022715008,
0.014139757,
-0.027607473,
-0.034784876,
0.023561781,
0.02547038,
0.02776876,
0.031827893,
-0.002856177,
-0.017137062,
0.002305103,
0.034166597,
-0.0026730457,
0.0054233763,
-0.010934118,
0.0050974363,
0.004321228,
0.0023605463,
0.02467737,
0.02435479,
0.011142451,
-0.024865542,
0.0022076569,
-0.011706966,
0.0036995893,
-0.004885743,
-0.007883049,
-0.0113978265,
0.032822516,
0.016895128,
0.0052184034,
0.01837362,
0.0058904453,
0.0022395789,
-0.028494567,
-0.02064512,
0.0048286193,
-0.02599457,
-0.014690831,
0.004559803,
0.0008921353,
-0.008897832,
0.012090029,
-0.011639762,
-0.009180089,
0.00951611,
-0.016249968,
0.034596704,
0.011733848,
0.0069085886,
0.008084661,
0.026532205,
0.02145157,
0.024059093,
-0.017016094,
0.01677416,
0.0074798237,
0.010813151,
-0.0024227102,
0.012392448,
0.011001322,
-0.0020598078,
-0.007889769,
0.0002515956,
-0.035107456,
0.028145105,
0.009858851,
-0.0035080574,
0.011068527,
-0.0030443487,
0.01079971,
-0.019247273,
-0.0018749962,
0.008400521,
-0.00886423,
-0.028037578,
0.007405899,
0.0015339351,
0.015739216,
-0.014220402,
-0.02159942,
-0.001370125,
-0.023118233,
-0.000057806083,
0.00709676,
0.0000822201,
-0.009751325,
0.02337361,
0.003854159,
0.009556432,
0.003837358,
0.0073252544,
0.0070093945,
0.0055409838,
0.008857509,
-0.02274189,
0.017284911,
-0.001918679,
0.025403176,
-0.024946187,
-0.03793003,
-0.011666643,
0.00056703517,
0.010994602,
0.015779538,
-0.005497301,
-0.023413932,
0.082257904,
0.014556423,
-0.043279484,
0.0267607,
-0.033790257,
0.044946145,
0.01759405,
0.009825249,
0.00064516,
-0.030887036,
-0.0018531549,
-0.02032254,
0.016639752,
-0.059139665,
-0.02305103,
0.017795663,
0.024287585,
0.029892413,
-0.0064717615,
-0.018118244,
0.018198889,
0.003531579,
0.021693505,
0.013776855,
-0.023413932,
-0.000050088107,
0.026801022,
0.007224448,
0.0043145074,
-0.018494587,
0.014206961,
-0.010127668,
-0.021384366,
0.012587341,
0.009986539,
0.010134389,
0.011357504,
-0.05543,
0.019059101,
0.006881707,
0.012473093,
-0.0061357403,
-0.012157233,
-0.004143137,
-0.00451276,
-0.015564485,
-0.004240583,
0.004889103,
-0.0057862788
] |
CONTEXT Osteoporosis causes substantial morbidity and costs $13.8 billion annually in the United States. Measurement of bone mass by densitometry is a primary part of diagnosing osteoporosis and deciding a preventive treatment course. Bone mineral densitometry has become more widely available and commonly used in practice. OBJECTIVE To review evidence about the value of various clinical applications of bone densitometry. DATA SOURCES A MEDLINE search was performed to update previous meta-analyses of the relationship between various measurements of bone density and risk of vertebral and hip fracture. We used data from the prospective Study of Osteoporotic Fr | [
-0.009255268,
-0.018850898,
0.023550533,
-0.050714154,
0.004876361,
0.0063490877,
-0.021678533,
-0.0064603603,
-0.011650903,
0.0020356353,
0.004139998,
0.013706175,
0.009078541,
-0.009929449,
-0.016429082,
0.01624581,
0.045608703,
0.007893814,
0.01830108,
-0.009235632,
-0.043487977,
0.0075665414,
-0.020919262,
0.0027981803,
-0.007389814,
0.011526539,
0.03120871,
-0.024008714,
-0.011101085,
-0.008836359,
0.013064721,
0.0016339083,
-0.007573087,
-0.00081122684,
-0.010498904,
0.01566981,
0.000491727,
0.00489927,
0.018929444,
-0.02177017,
-0.0063490877,
-0.011670539,
0.0064178146,
-0.010904721,
0.019570898,
0.003292362,
0.02321017,
-0.0019325444,
-0.025775986,
-0.020395625,
-0.011061812,
0.04351416,
-0.030554166,
0.03689016,
0.0100341765,
-0.036209434,
0.0033545436,
0.018981809,
0.015290174,
-0.032989074,
-0.034926526,
-0.017018173,
-0.03901089,
0.0041629067,
-0.023327988,
-0.016337445,
-0.007141087,
0.011186176,
-0.0042349068,
-0.006257451,
0.025880713,
0.034481436,
-0.0042839977,
-0.002896362,
0.019099627,
-0.017973809,
0.0032874527,
-0.0001287613,
-0.00602836,
0.00330218,
0.025854532,
-0.016363628,
-0.02643053,
0.039089434,
0.016913446,
0.015172356,
-0.01710981,
0.01929599,
-0.009621813,
-0.0005759997,
-0.007062542,
-0.0011519993,
-0.0010709994,
0.0175549,
-0.018536717,
0.0103745395,
0.012488721,
0.03945598,
-0.02366835,
0.00021231807,
0.0069119963,
0.012495266,
-0.02597235,
-0.009935995,
-0.018104717,
0.009687267,
0.004879634,
-0.00076377235,
-0.005066179,
-0.024021806,
-0.020735988,
0.06126542,
-0.0020847262,
-0.0023694532,
0.03089453,
-0.0031090893,
0.014570174,
0.00468327,
0.016573083,
0.011742539,
0.0033676345,
-0.01240363,
0.03843489,
0.0047749067,
0.01464872,
-0.0058941785,
-0.021364352,
-0.0019030899,
0.019623263,
0.015211628,
-0.012475629,
0.002128908,
0.032020345,
0.010858904,
-0.047650885,
0.0029290894,
0.004339634,
-0.0067287236,
-0.008653087,
-0.046367977,
-0.00042340887,
0.017711991,
-0.018392717,
-0.026168713,
-0.0068269055,
0.041131616,
0.0005391815,
0.008155632,
-0.008967268,
-0.013247993,
-0.020015988,
-0.020984717,
0.00083781773,
0.03408871,
-0.004938543,
-0.013084357,
0.03291053,
0.028223986,
-0.0045130886,
-0.02756944,
-0.029192712,
-0.0065519963,
0.005075997,
-0.0057698153,
-0.011807994,
0.011146903,
-0.010826176,
-0.019780353,
0.0011528175,
-0.013018902,
-0.004532725,
0.048959974,
-0.013051629,
0.01538181,
-0.008613814,
0.00008989768,
-0.018458173,
0.0050236336,
-0.031575255,
-0.020814534,
-0.037335254,
0.0060414514,
0.011722903,
0.008783995,
-0.0067876326,
0.03332944,
0.02974253,
0.007618905,
0.013071266,
-0.031391982,
0.022267625,
0.00398618,
0.008666177,
-0.01830108,
-0.65014654,
-0.020709807,
0.0047749067,
-0.014282174,
0.0010906358,
0.011801449,
0.021220353,
-0.0032874527,
-0.008247268,
0.008365086,
-0.001718181,
0.0023890897,
-0.00674836,
-0.038722888,
-0.01843199,
-0.011199267,
-0.015473446,
-0.034062527,
0.0018032718,
-0.009569449,
-0.034507617,
0.020029081,
-0.0034265437,
0.0181309,
0.0053836335,
0.011735993,
0.014020356,
0.0046439976,
0.021141807,
0.02060508,
-0.007736723,
0.02106326,
-0.004634179,
0.03644507,
0.03830398,
-0.010924358,
-0.017895263,
0.017698899,
-0.011009448,
0.00020331808,
-0.012102539,
0.0009793631,
0.032282166,
0.0025969078,
-0.027045803,
0.0037145435,
0.0065421783,
0.009451631,
0.022123624,
-0.0029356347,
0.01053163,
0.0094123585,
-0.009719995,
-0.0005698633,
0.01123854,
-0.0037112706,
0.025304714,
-0.041733798,
0.013627629,
-0.013306902,
0.0011102721,
0.009294541,
0.012442903,
-0.018104717,
-0.019688716,
0.005298543,
-0.0045229066,
0.011441449,
0.011303994,
-0.006191997,
0.018497445,
0.022254534,
-0.016638536,
-0.017947627,
0.0490647,
0.012698175,
0.039063253,
-0.0028652712,
-0.025069078,
-0.00540327,
0.0010881813,
0.011768721,
-0.02436217,
-0.0059596333,
0.020421807,
-0.010780358,
-0.009863995,
0.008692359,
0.028669076,
0.000028099417,
0.014910538,
0.02221526,
0.0016821809,
-0.04063416,
0.0011945448,
0.007998541,
0.012750539,
0.014701083,
0.021861807,
0.005183997,
-0.044221066,
0.027071986,
-0.004247998,
0.0039501796,
0.0019750898,
0.021665443,
-0.031287257,
0.025789076,
0.041917067,
-0.016036356,
0.0172669,
-0.023786169,
-0.025213078,
0.0033610892,
-0.0014277265,
-0.023013806,
0.028747622,
0.008528722,
-0.02221526,
0.004198907,
0.0125999935,
0.01466181,
0.024493078,
-0.0071738143,
0.02017308,
-0.00020219307,
0.0032465437,
-0.009968722,
0.001019454,
-0.02467635,
-0.0109767215,
-0.000004992185,
0.014007266,
-0.012959993,
0.031103984,
0.016141083,
0.0010701813,
0.00696436,
0.008103268,
-0.031679984,
-0.01204363,
-0.038382526,
0.02437526,
-0.029087985,
-0.0139418105,
-0.00892145,
-0.004886179,
0.00047127248,
0.020369444,
0.020971626,
-0.021979624,
-0.032020345,
-0.017895263,
-0.016638536,
-0.013745448,
-0.016520718,
0.013162902,
0.013202175,
-0.0053574517,
-0.02365526,
-0.011919267,
-0.022869807,
-0.025409441,
0.0046472703,
-0.0055014514,
-0.03291053,
-0.0041039977,
-0.0084698135,
-0.014871265,
-0.019570898,
-0.00008498859,
-0.0024119988,
-0.007618905,
-0.012887993,
0.0033676345,
0.015709082,
0.0063098148,
-0.017960718,
0.0040221796,
-0.020932352,
0.010184722,
0.0016821809,
-0.010970176,
0.006404724,
0.027071986,
0.0040810886,
0.018392717,
0.0053279973,
0.013981083,
0.014229811,
0.003120544,
0.016088719,
-0.0078283595,
0.014792719,
0.011441449,
-0.023537442,
-0.0045719976,
-0.0038781797,
0.01102254,
0.013097447,
0.036837798,
-0.0017132718,
0.030397074,
0.024964351,
0.017594172,
-0.01349672,
0.02932362,
0.00489927,
0.025658168,
-0.0064439964,
-0.008941086,
-0.018484354,
0.013522902,
-0.017371627,
-0.00041563614,
0.01320872,
-0.0031221802,
-0.0071869055,
-0.005010543,
-0.012181085,
-0.010898176,
-0.004509816,
0.03859198,
0.015813809,
-0.016023263,
-0.0014195447,
0.016520718,
-0.00041624976,
0.03686398,
-0.00060259056,
-0.016363628,
0.01594472,
0.0037767251,
0.013588357,
-0.0073767235,
0.016769446,
0.0034298163,
-0.000049193157,
0.0036425435,
0.006951269,
0.008567995,
0.0027130896,
0.02974253,
0.0024643624,
-0.015041446,
-0.017332355,
0.012095993,
-0.008986904,
-0.010544722,
0.004041816,
0.019243626,
-0.02044799,
0.00007215337,
-0.0094123585,
0.016586173,
-0.014753447,
0.027909804,
0.027831258,
0.048829064,
0.024977442,
0.041000705,
0.01785599,
0.013405084,
0.005125088,
0.02525235,
-0.0041694525,
0.0047061793,
0.018261809,
-0.010688721,
-0.016573083,
-0.03804216,
-0.016285082,
0.012495266,
-0.028014531,
0.016612355,
0.007383269,
0.0052854517,
0.018890172,
0.033015255,
0.011644358,
-0.022136716,
-0.02859053,
-0.009287995,
0.024911987,
-0.0145832645,
-0.010943994,
0.012148357,
-0.020094534,
-0.0031958164,
0.018759262,
0.013398538,
-0.019924354,
-0.0075272685,
-0.03133962,
-0.0116574485,
0.013110538,
0.013365811,
0.00025056806,
0.012141812,
0.017607264,
0.008869086,
-0.012711266,
-0.012292357,
-0.026731621,
0.053567972,
-0.00044959068,
-0.015774537,
-0.010996358,
-0.013431266,
-0.01494981,
-0.0009269995,
-0.020186171,
-0.020801444,
-0.0016232718,
-0.002436544,
0.017070536,
0.011114175,
0.016730173,
0.004617816,
-0.0132414475,
-0.0010300904,
-0.02830253,
-0.0053378153,
-0.014321447,
0.031313438,
0.012017448,
0.003707998,
0.0041694525,
-0.011179631,
0.0074421777,
-0.001344272,
0.00341018,
0.009739631,
0.0142036285,
0.0046439976,
0.020042172,
0.004045089,
0.027124349,
-0.02118108,
0.013254538,
0.008410905,
-0.015250901,
0.018157082,
-0.008351996,
-0.01168363,
0.009458177,
0.049562156,
0.039377432,
0.027124349,
-0.024414532,
0.006666542,
0.036759254,
0.007880723,
0.0009040904,
-0.030056711,
0.014897446,
0.0013180902,
0.008109814,
-0.01915199,
-0.008378177,
-0.0145439925,
-0.00540327,
0.0024512715,
0.0021125444,
0.0030059984,
0.0072719962,
0.00833236,
0.019256717,
0.005255997,
-0.01008654,
0.007010178,
0.030868348,
0.031967983,
0.005010543,
0.022529442,
0.008725086,
-0.02581526,
-0.033617437,
0.00007153973,
-0.012757084,
-0.010623267,
-0.005363997,
-0.027647985,
-0.007586178,
-0.014622537,
0.0016633627,
0.012717811,
-0.014373811,
-0.029978165,
-0.020225443,
-0.043723613,
0.0073963595,
-0.00620836,
0.0178429,
-0.007455269,
-0.009215995,
-0.0031974528,
-0.0050007245,
0.005134906,
0.000947454,
0.0107149035,
-0.014766538,
0.0048370883,
0.00024913624,
-0.01612799,
0.01801308,
-0.0046799975,
-0.04555634,
-0.008810177,
0.0025739986,
0.0028685438,
-0.01945308,
-0.024623986,
0.0054196334,
0.0065323603,
0.0007379996,
0.0142036285,
0.0075272685,
-0.0019030899,
-0.022712715,
0.01312363,
0.009464722,
-0.001997999,
-0.019073443,
-0.0010759085,
0.010525085,
-0.0051316335,
-0.032413073,
0.034874164,
0.007285087,
-0.027674166,
0.0040614526,
0.027229076,
-0.010119268,
0.0003035453,
-0.0049581793,
-0.0020078172,
-0.023026897,
0.023406534,
-0.0065650875,
-0.011513448,
0.019858899,
0.019413808,
0.00097281765,
0.030004347,
-0.009405813,
0.031994164,
0.000035284073,
-0.020513443,
-0.013876356,
-0.019688716,
-0.0056945425,
-0.04744143,
-0.010642904,
0.0044050887,
0.015316355,
0.0050236336,
-0.013549084,
-0.015277083,
0.008986904,
-0.029716348,
-0.0036032707,
-0.020264717,
-0.0039174524,
-0.0008779086,
0.02526544,
-0.0106559945,
-0.014125084,
0.04338325,
-0.035869073,
-0.023131624,
-0.011533084,
-0.009667631,
0.023131624,
-0.016559992,
0.003946907,
-0.026129441,
-0.011402176,
0.0068530873,
-0.012901084,
-0.0006369542,
-0.0010587267,
0.02105017,
-0.011002903,
0.032543983,
0.017790535,
-0.0076123597,
0.02366835,
-0.015892355,
0.0020421806,
-0.017751263,
-0.0017836355,
0.00024852259,
0.021010898,
0.04063416,
-0.00024749988,
0.024074169,
-0.008194905,
0.013994174,
0.008967268,
-0.004624361,
-0.031679984,
-0.03437671,
-0.011886539,
-0.009877086,
-0.006224724,
0.003779998,
0.00031193165,
-0.037518524,
-0.013758538,
0.03089453,
0.007893814,
0.016730173,
-0.025343986,
0.0054065427,
-0.02015999,
0.00065659056,
0.0045621796,
-0.034612346,
-0.017751263,
-0.0040156343,
-0.018052354,
-0.015041446,
0.020644352,
-0.031418163,
0.009628358,
0.013117084,
0.0005661815,
-0.015303264,
0.00985745,
-0.010021086,
-0.016075628,
-0.026063986,
-0.033905435,
-0.025003623,
-0.0041923616,
-0.028381076,
-0.025042895,
0.007226178,
0.044639975,
-0.0068989056,
0.025330896,
-0.0005129997,
-0.0001220113,
0.014674901,
-0.0020094535,
-0.002318726,
-0.001889999,
0.037937433,
-0.00085418136,
-0.02351126,
-0.03267489,
0.010341813,
0.02090617,
-0.0040876344,
0.032962892,
0.028799985,
-0.024689442,
-0.008430541,
0.011539631,
0.001308272,
-0.009320722,
-0.025069078,
0.0029438166,
0.002403817,
-0.026509076,
-0.0014489993,
-0.0055832695,
0.0048338156,
0.011159994,
-0.0031287256,
0.0017132718,
-0.010289449,
-0.020225443,
0.00055718154,
0.027019622,
-0.03521453,
0.012233448,
-0.008803632,
-0.022909079,
0.008260359,
-0.011879994,
0.005462179,
0.020945443,
-0.0023350897,
0.020657444,
-0.019086536,
0.0012706356,
0.0040712706,
0.015551992,
0.0017885445,
-0.0032710892,
-0.032989074,
0.030580347,
0.003671998,
0.0059989057,
0.01102254,
-0.004948361,
0.0029225438,
0.0010849085,
-0.018117808,
-0.012069812,
-0.017882172,
0.025893804,
0.002156726,
0.014085811,
-0.033015255,
0.0026099987,
-0.025501078,
-0.01844508,
-0.01066254,
-0.009877086,
0.01328072,
-0.0016134537,
-0.03144435,
0.02205817,
0.023825442,
0.023615988,
0.0048436336,
-0.016730173,
-0.0040810886,
0.013771629,
-0.021704717,
0.030239984,
0.031391982,
-0.007298178,
-0.041917067,
0.012449448,
-0.027124349,
-0.02118108,
-0.0036850888,
-0.0057207244,
-0.024283623,
-0.020866899,
0.0030010892,
0.012010903,
0.011788357,
-0.014491629,
0.0055996333,
0.010623267,
0.024859624,
-0.012927266,
-0.037806526,
0.01987199,
0.015735265,
-0.0041465433,
-0.001894908,
-0.005651997,
0.012855266,
-0.023354169,
-0.013679992,
0.003531271,
0.01756799,
-0.006211633,
-0.028093075,
0.046525065,
-0.0020912716,
-0.014491629,
-0.019531626,
0.0097919945,
-0.006997087,
0.018091626,
-0.007939632,
-0.0024119988,
0.0027850894,
-0.023458896,
-0.0030239983,
-0.003256362,
-0.009157086,
-0.031287257,
0.00083781773,
-0.0039894525,
-0.02814544,
-0.0043494524,
-0.0057272697,
0.044168703,
0.016520718,
-0.0049516335,
-0.006067633,
-0.006509451,
-0.041864704,
-0.02451926,
0.008509086,
-0.0017427263,
0.014936719,
0.046970155,
0.034638528,
0.03479562,
0.009556359,
0.0025412713,
-0.034586165,
-0.0159709,
0.005354179,
-0.010786903,
0.014727265,
0.012370902,
-0.036680706,
-0.021495262,
0.018942535,
-0.015565082,
0.016703991,
0.023236351,
0.01175563,
-0.007383269,
-0.010079995,
-0.003120544,
-0.005174179,
0.014229811,
0.024597805,
-0.035607252,
0.0032776345,
-0.0066632694,
0.0065159965,
-0.0053476337,
-0.0038061799,
-0.008371632,
-0.026365077,
0.017463263,
-0.027359985,
0.019570898,
0.022005806,
-0.022306897,
-0.0073767235,
0.021809442,
0.013758538,
0.030266166,
0.009968722,
0.009399268,
-0.011205812,
0.026351986,
-0.016926536,
0.004041816,
-0.011847266,
-0.003436362,
-0.0021763626,
-0.010832721,
-0.003953452,
-0.02770035,
0.014766538,
-0.009988358,
-0.012089448,
-0.037335254,
0.023039987,
0.003505089,
-0.01509381,
-0.0035869072,
-0.02929744,
-0.0037538162,
-0.015774537,
-0.019125808,
-0.012004357,
-0.03526689,
-0.02581526,
0.025134532,
-0.015460355,
-0.0068007237,
0.0060479967,
-0.03935125,
-0.0047356337,
0.019322172,
0.18002608,
-0.0064603603,
-0.010957085,
0.03644507,
0.019963626,
0.010453085,
0.002714726,
-0.0010513631,
-0.010786903,
0.022463989,
0.025775986,
-0.015826901,
-0.0026918168,
0.0052167247,
0.030606529,
-0.014190538,
-0.0168349,
-0.008567995,
0.01102254,
0.006198542,
0.005946542,
0.0029470893,
-0.008175269,
0.0074094506,
0.03238689,
0.009608722,
0.007062542,
0.010184722,
0.029794892,
0.018209444,
-0.0011127266,
-0.008253814,
-0.0018490899,
0.011186176,
-0.018091626,
-0.005766542,
-0.0021485444,
-0.023602897,
-0.0069119963,
0.020408716,
-0.0032645436,
-0.006594542,
-0.014046538,
-0.0064210873,
0.024767987,
0.0077432687,
0.0116574485,
0.005494906,
-0.005435997,
0.020984717,
-0.029821075,
0.013319992,
0.014727265,
0.0116574485,
-0.005429452,
0.008973814,
0.0072327233,
-0.00021927261,
0.006578178,
-0.016271992,
0.009183268,
-0.0058745425,
-0.002783453,
0.018811626,
-0.032465436,
0.00461127,
0.0006635451,
0.010263267,
0.006833451,
-0.0073701777,
0.008574541,
0.02483344,
-0.013601447,
0.013876356,
-0.0076385415,
-0.013522902,
0.018589081,
0.014386902,
-0.0154865375,
-0.0076254504,
0.0004606361,
-0.012311993,
0.008024723,
-0.0039730887,
-0.0021027261,
-0.020801444,
-0.0006467724,
0.007573087,
0.020042172,
-0.010943994,
-0.01335272,
-0.011205812,
-0.005429452,
0.0037374524,
0.018536717,
0.0014923628,
-0.01277672,
0.011271266,
-0.031549074,
-0.016651627,
-0.018157082,
0.08226323,
0.011461085,
0.008999995,
0.013300356,
-0.01451781,
-0.053594153,
0.026365077,
0.006319633,
0.015342537,
0.014190538,
-0.04356652,
0.01059054,
-0.028328713,
-0.008122905,
0.007605814,
0.020421807,
-0.028826166,
0.010701813,
-0.025893804,
0.017306173,
-0.0148058105,
0.014399992,
0.014962901,
-0.011349812,
-0.00301418,
0.041733798,
0.0018752717,
-0.0007633632,
-0.019243626,
-0.00008836359,
0.0076581775,
0.0004229998,
0.008096723,
-0.0026558167,
0.016625445,
-0.007258905,
-0.0007109996,
-0.026155623,
0.026286531,
-0.009117813,
-0.010636358,
0.0035934527,
0.010793448,
0.022319987,
-0.0037636342,
0.0037865434,
-0.00021661352,
-0.0122989025,
-0.015106901,
-0.044273432,
0.009523631,
0.0008251359,
-0.020696716,
0.01364072,
-0.0069839964,
-0.018811626,
-0.02175708,
-0.0071869055,
0.007782541,
-0.019348353,
0.0026558167,
0.033303253,
-0.0055472697,
-0.0028849076,
0.010799995,
-0.16442174,
0.010132358,
0.014570174,
-0.045032702,
0.0069905417,
-0.013103993,
-0.0012861812,
-0.018942535,
0.010459631,
-0.018942535,
-0.00092372677,
0.020683626,
-0.0077890866,
-0.024898896,
-0.009746176,
-0.0076385415,
-0.014033447,
0.026456714,
0.013090902,
0.00332018,
0.0059694513,
-0.0045065433,
0.035319254,
-0.037230525,
0.014687992,
0.013994174,
0.016703991,
0.048069794,
0.0076581775,
-0.005308361,
-0.024479987,
-0.0051054517,
-0.0020176354,
0.0037178162,
-0.019073443,
-0.0040614526,
0.0061625424,
-0.00091145403,
0.00005650565,
0.008378177,
0.016808718,
0.03191562,
0.008378177,
-0.005033452,
0.008685813,
0.025802167,
0.026299622,
-0.031130165,
0.025749804,
-0.0032498164,
0.016023263,
-0.020081444,
0.020212352,
0.0071607237,
-0.008613814,
0.0019472716,
-0.006057815,
0.037727978,
0.005449088,
-0.034481436,
-0.010819631,
-0.019505445,
0.008934541,
-0.002899635,
-0.014177447,
-0.015146174,
-0.004270907,
-0.001984908,
-0.011205812,
-0.004568725,
-0.007815269,
-0.0060381787,
-0.0046047247,
0.016036356,
0.010754176,
0.019793443,
0.026155623,
-0.012442903,
0.0154865375,
0.0003798407,
0.003505089,
-0.0025658167,
-0.0016838172,
-0.03191562,
-0.011258176,
0.004306907,
0.016952718,
0.019492352,
0.001835999,
-0.0029961802,
0.02508217,
-0.038146887,
0.021351261,
-0.0036654526,
-0.00036654525,
0.008279996,
-0.011938903,
0.007003633,
0.013876356,
0.0018441809,
-0.008437087,
0.0032727255,
-0.009680722,
0.027726531,
0.023458896,
0.0014571811,
0.003040362,
0.00024913624,
-0.01059054,
-0.0028767257,
-0.012442903,
0.014491629,
0.020356353,
0.017581081,
-0.016154174,
0.023275623,
0.021796351,
0.0077694505,
-0.013156356,
-0.009883631,
0.041053068,
0.0021665443,
-0.04827925,
0.021717807,
-0.010564358,
-0.016743263,
-0.11509521,
0.011506903,
-0.0013745447,
0.022686534,
0.024597805,
0.015316355,
-0.0071149054,
0.007357087,
-0.006872724,
0.02319708,
-0.028223986,
-0.021076353,
-0.02205817,
-0.005255997,
-0.0008517268,
-0.027988348,
-0.00935345,
-0.027255258,
-0.0097330855,
0.0330938,
0.020029081,
-0.006391633,
0.0067810873,
-0.0052854517,
0.0011086358,
-0.026351986,
-0.018314172,
0.027543258,
-0.0026018168,
0.0045359978,
0.0026050895,
-0.0034559981,
0.0045589064,
-0.01451781,
-0.013103993,
-0.009706904,
-0.008980359,
0.00398618,
0.02159999,
-0.003920725,
0.016861081,
0.031837072,
0.008077087,
0.010970176,
0.005377088,
-0.017384717,
-0.028093075,
-0.015695991,
-0.005059634,
0.0024152715,
-0.009968722,
-0.038722888,
-0.015394901,
-0.020002898,
0.0023399987,
-0.03207271,
-0.003658907,
-0.0010210903,
0.0070429053,
-0.0043494524,
-0.006866178,
0.01987199,
-0.0032907254,
0.03613089,
0.008116359,
-0.02885235,
-0.024178896,
-0.021992715,
-0.017816719,
0.0016682718,
-0.012050175,
0.006463633,
-0.009307631,
-0.016285082,
-0.034324344,
0.005750179,
-0.025658168,
-0.011343267,
0.0116770845,
-0.010007994,
-0.018680718,
-0.012167994,
0.015224719,
-0.014792719,
0.0029241804,
0.014098901,
0.004067998,
0.01328072,
0.017423991,
-0.029873438,
-8.133874e-7,
0.020487262,
-0.005759997,
-0.008783995,
-0.0042872704,
0.024951259,
0.0009081813,
-0.020120716,
-0.0030256347,
0.014491629,
-0.03325089,
-0.0044639977,
-0.048383974,
0.017083628,
0.04367125,
-0.009359995,
-0.0061494512,
-0.028407257,
0.026142532,
-0.013876356,
0.020775262,
-0.0060021784,
-0.028747622,
0.026456714,
0.01161163,
-0.0009957268,
-0.016285082,
-0.024859624,
0.051473428,
0.018785445,
0.022869807,
0.027621804,
0.000098284036,
0.008378177,
0.015918536,
0.04267634,
0.002264726,
-0.0035345436,
-0.0106559945,
0.016298173,
-0.011212357,
-0.015722174,
-0.0018032718,
-0.035031255,
-0.013470538,
-0.011539631,
-0.01421672,
-0.017031264,
-0.011932357,
-0.0030649074,
0.030606529,
0.013679992,
-0.0000034005664,
-0.018759262,
0.0030747256,
-0.01349672,
-0.0106952675,
-0.0004209543,
0.00012323857,
0.0005543179,
-0.005422906,
-0.021429807,
0.024754897,
0.01102254,
0.011552721,
-0.018942535,
-0.03471707,
-0.005579997,
-0.0055865427,
0.0004655452,
-0.001452272,
-0.004879634,
0.032622527,
0.016717082,
-0.005773088,
-0.008698905,
0.002976544,
-0.015211628,
-0.014975992,
-0.001407272,
-0.007546905,
-0.02408726,
-0.023589805,
0.016991992,
0.01159854,
0.0050498154,
-0.000050855087,
0.020382535,
-0.014897446,
0.011788357,
0.0063949055,
0.023733806,
0.017018173,
0.014269084,
-0.01407272,
0.030868348,
0.023236351,
-0.008613814,
-0.03264871,
0.033512708,
0.017895263,
0.008941086,
-0.006110179,
0.014347629,
-0.0069119963,
0.012364357,
0.018078536,
-0.0053738155,
0.008463268,
0.0013000902,
0.00067540875,
0.012829084,
0.0069709052,
0.007854541,
-0.005164361,
-0.024466896,
-0.029768711,
0.005426179,
-0.035738163,
-0.036733072,
-0.016429082,
0.018772354,
-0.0006602724,
0.023681441,
0.008908359,
0.009104722,
-0.003333271,
0.013333084,
0.015800718,
-0.021351261,
-0.0006942269,
0.025435623,
0.010125813,
0.025370168,
-0.018693808,
0.0008566359,
0.029716348,
0.00805745,
0.00468327,
-0.027962167,
0.010708358,
-0.015656719,
0.006188724,
-0.030239984,
-0.030213801,
-0.0053018155,
0.012161448,
-0.019466171,
-0.008639995,
0.009536722,
-0.0028472713,
0.07430396,
0.002765453,
-0.0018523626,
0.013300356,
-0.0132218115,
-0.0066305418,
0.0021452715,
0.029192712,
-0.018327262,
-0.014177447,
0.018078536,
-0.0030796346,
-0.014308356,
0.00052486337,
-0.01008654,
0.025841441,
0.004303634,
0.019806534,
-0.011709812,
0.008685813,
-0.0033905436,
-0.007906904,
0.008797086,
0.011847266,
0.0042938157,
-0.018104717,
0.011074903,
0.02785744,
-0.013333084,
-0.025906894,
-0.0023710895,
0.0072523598,
-0.01159854,
0.0064570876,
0.01494981,
-0.006486542,
-0.0058614514,
-0.020343263,
-0.030213801,
-0.0051709064,
0.0012608175,
0.021259625,
-0.0077563594,
-0.015434174,
-0.035397798,
-0.002701635,
-0.005566906,
-0.01666472,
-0.026024714
] |
Vascular calcification is an advanced feature of atherosclerosis for which no effective therapy is available. To investigate the modulation or reversal of calcification, we identified calcifying progenitor cells and investigated their calcifying/decalcifying potentials. Cells from the aortas of mice were sorted into four groups using Sca-1 and PDGFRα markers. Sca-1(+) (Sca-1(+)/PDGFRα(+) and Sca-1(+)/PDGFRα(-)) progenitor cells exhibited greater osteoblastic differentiation potentials than Sca-1(-) (Sca-1(-)/ | [
-0.004426216,
-0.009323664,
0.0076137646,
-0.029485667,
-0.01961672,
0.027439173,
-0.03392871,
0.002211425,
-0.03034735,
-0.008017678,
0.0220402,
0.008159048,
-0.00018680988,
0.012265499,
-0.021609358,
-0.0026742422,
0.03449419,
-0.012312622,
0.019684039,
0.008105192,
-0.017556762,
0.03672918,
-0.008764917,
-0.0022450844,
-0.020559184,
0.021555504,
0.0039819116,
-0.032474626,
-0.008791845,
-0.018054921,
0.017179776,
0.0117269475,
-0.008192707,
-0.029000971,
-0.005961086,
-0.004372361,
-0.017045138,
-0.018485762,
0.0133224055,
0.008071533,
0.0028913456,
-0.022026736,
-0.00027537628,
-0.031478304,
-0.004665198,
-0.017651008,
-0.016520051,
-0.004308408,
-0.011639433,
0.026106259,
0.02264607,
-0.002445358,
0.013396456,
0.006301047,
-0.009727578,
-0.0014481973,
0.0069069164,
0.013726318,
0.0015466511,
-0.015267921,
-0.007236779,
0.0034315796,
-0.026160115,
0.0040963534,
-0.012931956,
0.0106094545,
-0.019414764,
0.029458739,
0.0004905863,
-0.002938469,
0.021151591,
0.018431908,
-0.002034713,
-0.014352384,
0.006637641,
-0.01384076,
-0.027223753,
-0.006169775,
-0.009269809,
0.013288746,
0.0042814803,
-0.030912828,
-0.008838968,
0.039071873,
0.019401299,
0.00117219,
-0.023588534,
0.013564753,
-0.01929359,
-0.0047055893,
0.019912923,
0.032824684,
0.006630909,
0.017031675,
-0.010717165,
-0.0203303,
-0.0015382363,
0.021959417,
0.0073108296,
-0.019993706,
0.00080782647,
0.000433786,
0.0024941643,
-0.025648491,
-0.041629992,
0.0027398781,
-0.008603352,
0.009552549,
0.034144133,
0.006341438,
-0.026267825,
0.05617087,
-0.005122966,
-0.02582352,
0.040499035,
-0.031235958,
0.023507752,
-0.0025480194,
0.0018664158,
0.0029233221,
0.016600834,
0.0150525,
0.030724334,
-0.021703605,
0.007876309,
0.018068386,
0.0024672367,
0.019576328,
-0.028489348,
0.0020128344,
0.005213847,
0.0021491551,
-0.01483708,
0.004055962,
-0.017233633,
-0.020545721,
-0.019266661,
0.007842649,
-0.012191448,
-0.046315387,
-0.022215229,
0.016748937,
-0.027075652,
-0.016883574,
-0.03139752,
-0.00029452008,
0.030078074,
-0.0009668673,
0.0027011698,
-0.006587152,
-0.01326855,
-0.012965615,
0.0063246083,
-0.021811316,
-0.009821824,
-0.012265499,
0.0007989909,
0.037994772,
-0.019037778,
-0.00406606,
-0.000671085,
-0.009936266,
0.029512595,
-0.007304098,
0.017341342,
0.0024369434,
0.007714743,
-0.010420961,
0.007835917,
-0.015617979,
-0.016614297,
0.01637195,
-0.019266661,
0.019576328,
-0.008536033,
-0.0038943968,
-0.01255497,
-0.00087093795,
-0.029970363,
-0.023440432,
-0.0069876993,
-0.0031269616,
-0.0041670385,
0.0104007665,
-0.0004079103,
0.006879989,
0.035598222,
-0.027708448,
-0.007936895,
-0.018176096,
0.017597154,
0.013881152,
-0.012151057,
-0.015012109,
-0.6372135,
-0.047742546,
0.014285065,
-0.015294848,
0.038264047,
0.04012205,
0.00065425533,
-0.022417186,
-0.016829718,
0.0026557297,
-0.0069809672,
0.0169105,
-0.004237723,
0.0042511867,
-0.0029064924,
-0.02760074,
-0.004974865,
-0.02193249,
0.010387302,
0.0054730247,
-0.01390808,
0.00032775878,
0.002633851,
0.007600301,
0.010043976,
0.026348608,
0.026469782,
-0.014675515,
-0.0026086064,
0.039610427,
-0.02757381,
0.022699924,
-0.0045103645,
0.007425272,
0.049977534,
-0.00013190293,
-0.010656578,
0.027923869,
0.0117740715,
0.048065677,
-0.013813833,
0.012009687,
0.023534678,
0.0035510706,
-0.04518443,
0.011262448,
0.018526154,
0.004055962,
-0.016775863,
-0.0021053979,
0.011107614,
0.005536977,
-0.03242077,
0.01569876,
0.013813833,
-0.028920189,
0.033470944,
-0.0079907505,
-0.008179244,
-0.0036217554,
-0.0027870014,
0.026038941,
-0.0049950606,
-0.018889677,
0.007479127,
0.04111837,
-0.017098995,
0.0026153382,
0.008058069,
-0.0038943968,
0.01708553,
0.013611876,
0.0019589793,
-0.008960142,
0.009155367,
0.030374276,
0.024086693,
0.0068025724,
-0.004890716,
0.006280851,
0.012009687,
0.011928905,
-0.007553178,
0.024167476,
0.020141806,
0.011168201,
-0.038937237,
0.025258042,
0.0045675854,
0.0038304438,
0.01041423,
-0.0026102893,
-0.03142445,
-0.06333359,
0.008084997,
0.027183361,
0.022457577,
0.010239201,
-0.008010946,
-0.026012013,
-0.016210385,
-0.007889772,
0.009350591,
0.006284217,
0.021299692,
0.00029599268,
-0.036809962,
-0.041333787,
0.019885996,
-0.05735568,
0.0057254704,
-0.0020195663,
-0.013746514,
-0.01316084,
-0.0026220703,
-0.01544295,
0.012346282,
-0.0021643017,
-0.02011488,
-0.021165054,
0.011376889,
-0.013154108,
0.0060284054,
-0.00952562,
0.027116043,
0.0024234795,
-0.0051633576,
-0.012884833,
-0.008919751,
-0.012366477,
-0.0064457823,
-0.008367736,
0.023238475,
-0.020464938,
0.02582352,
-0.0035813642,
-0.006344804,
0.000060166243,
0.012925223,
-0.01233955,
-0.018378053,
-0.018041458,
0.00059156463,
-0.015321775,
-0.0018613669,
0.006516467,
-0.002386454,
0.0033945541,
-0.001584518,
0.024988767,
-0.011632701,
-0.0022635972,
-0.015133283,
-0.0013388041,
0.008320613,
0.0011772388,
-0.00017955207,
-0.011868318,
-0.0029098582,
-0.005775959,
-0.018391516,
-0.0014784908,
-0.011989491,
0.0075599095,
0.012238571,
-0.011282643,
-0.01277039,
-0.00093068345,
-0.020370692,
-0.010508476,
-0.012581898,
-0.01269634,
-0.0028879796,
0.01929359,
-0.0016930697,
0.0073108296,
-0.0086774025,
-0.004412752,
-0.01516021,
-0.007977286,
-0.006045235,
-0.050354518,
-0.009135171,
0.0004272645,
0.023359649,
0.027843086,
0.027398782,
0.017179776,
-0.0005082575,
0.030912828,
-0.009215954,
0.02768152,
-0.031289812,
0.0068934527,
-0.008663939,
-0.035328947,
-0.0056514195,
0.004857057,
0.012999275,
0.027156433,
0.027708448,
-0.012258767,
0.034467265,
-0.011619237,
0.01868772,
-0.0115182595,
0.001073736,
-0.005860108,
0.027735377,
0.017866429,
0.006644373,
0.0047661765,
-0.008179244,
-0.021905562,
0.004735883,
-0.00050699525,
0.008569692,
-0.019522473,
0.013207963,
-0.00027769036,
-0.010959513,
-0.004947937,
0.023507752,
-0.013935007,
-0.023090374,
0.017745255,
-0.01433892,
0.016735472,
0.006678032,
-0.0167624,
-0.025311897,
0.0007177875,
0.00991607,
-0.0044733393,
0.013382992,
0.024598317,
0.012629021,
-0.001496162,
0.016183458,
-0.00018607358,
0.020236054,
0.015389095,
0.02065343,
0.019091632,
-0.02956645,
-0.0052172127,
0.023561606,
0.018027995,
-0.023911664,
0.031235958,
0.0075060544,
0.011888513,
-0.00069086,
-0.0020700553,
0.0029956899,
-0.006264021,
0.03637912,
0.02300959,
0.035463583,
0.011397085,
0.011397085,
0.014298529,
-0.0040761577,
-0.010676773,
0.0013068276,
0.016358487,
0.0009635014,
-0.007923432,
-0.017166313,
-0.006109188,
-0.021878634,
-0.009047656,
0.004789738,
-0.03298625,
0.009518889,
0.0055773687,
0.023750098,
-0.01775872,
0.017274024,
-0.0006513101,
-0.009646795,
-0.04970826,
0.021999808,
0.011794267,
-0.00006363737,
-0.009444838,
-0.0134503115,
-0.020841923,
-0.010333447,
-0.006045235,
0.005452829,
0.0049445713,
-0.00526097,
-0.018983923,
-0.020141806,
0.010144955,
-0.0003837176,
0.0058197165,
0.01544295,
-0.0045103645,
0.004604611,
-0.007674352,
0.011524991,
-0.010811411,
0.03834483,
0.0077618663,
0.0139619345,
0.004557488,
0.0027651228,
-0.016291168,
-0.008657207,
-0.018660791,
-0.0010358691,
0.0028257098,
-0.015994964,
0.013988862,
0.01340992,
0.009572744,
0.02642939,
0.004480071,
0.0015542245,
-0.018660791,
-0.00015683194,
-0.015617979,
0.00848891,
0.008084997,
0.013584949,
-0.010010317,
-0.020128343,
0.013389724,
-0.006321242,
-0.0085023735,
0.03516738,
-0.018243415,
0.029997291,
0.007903236,
0.00877165,
-0.0056446875,
-0.00059577206,
0.03376715,
-0.004130013,
-0.0032094272,
-0.0036183896,
-0.010151686,
0.005018622,
-0.01316084,
0.0425186,
0.035652075,
0.033470944,
0.006940576,
0.0051835533,
0.0043891906,
0.0011831293,
0.0030411303,
-0.019374372,
0.01587379,
-0.004119915,
-0.009478497,
-0.0038674693,
-0.027466102,
-0.0030192516,
0.016991284,
-0.011282643,
0.018701183,
0.01444663,
0.023669316,
0.01384076,
-0.0029552986,
0.008704331,
-0.01569876,
0.005691811,
-0.0004358897,
0.028947117,
-0.017651008,
0.021663213,
-0.010690237,
-0.005907231,
-0.014729369,
0.015496805,
0.0006702435,
0.0026624615,
-0.008219634,
0.017502908,
-0.02368278,
-0.020061025,
-0.028004652,
-0.004857057,
-0.011397085,
-0.0032767463,
-0.004183868,
-0.012036615,
-0.015900718,
-0.008064801,
0.022726852,
0.015119819,
0.0028071972,
-0.03648683,
0.0016577273,
0.007398344,
0.020559184,
0.01929359,
-0.017354805,
0.002334282,
0.030966682,
-0.0032228911,
-0.028435493,
-0.012292426,
-0.028166218,
-0.0036823424,
0.0033625779,
-0.009121708,
-0.026833303,
0.009128439,
-0.0011284326,
0.020990025,
-0.00085032155,
-0.00063405966,
-0.015348704,
-0.010602723,
-0.0042612846,
0.03716002,
-0.0056985426,
-0.015119819,
-0.010017049,
0.006274119,
-0.009195758,
0.006041869,
-0.015469877,
-0.027385319,
0.002034713,
-0.0066578365,
0.0026153382,
-0.006210166,
-0.029970363,
-0.011652897,
0.0034282138,
0.005489854,
-0.018943531,
0.015429486,
0.011901977,
0.0076204967,
0.015227529,
0.009337128,
0.0061967024,
0.036513757,
0.017812574,
0.049196634,
-0.022834562,
-0.008973606,
0.011208593,
0.010871998,
-0.016075747,
-0.018876212,
-0.005924061,
-0.0012605459,
0.007573373,
-0.013699391,
-0.036675323,
-0.020101415,
-0.006974235,
0.0012883149,
0.00083265034,
-0.013248354,
0.00848891,
-0.0131945,
0.02681984,
0.005681713,
-0.014675515,
0.017933749,
-0.038317904,
-0.010434425,
-0.0008625231,
0.002866101,
-0.0007804782,
-0.029054826,
0.00006200699,
-0.0009929534,
-0.02264607,
-0.0030764726,
-0.019684039,
0.0031572552,
-0.025163796,
0.029431812,
0.028839406,
0.023238475,
0.0031589381,
0.008704331,
0.024140548,
0.010427694,
-0.006630909,
-0.0047493465,
0.01280405,
-0.015954573,
0.041683845,
0.009269809,
-0.010690237,
0.017529834,
-0.030670479,
0.04397269,
0.023992447,
-0.012743463,
-0.0148236165,
-0.0056547853,
-0.039206512,
-0.041899268,
-0.0019404666,
0.0186204,
-0.0066006156,
-0.026281288,
-0.00013537405,
0.048658084,
-0.0022265718,
-0.00004433579,
-0.001340487,
0.028731696,
0.006237094,
0.02835471,
-0.00010534352,
0.008576425,
0.023480823,
-0.018862749,
0.008690867,
-0.0056446875,
0.006459246,
0.0013657317,
-0.00023961312,
0.022242157,
-0.011464404,
-0.008697598,
0.0014380994,
-0.022592215,
-0.0028021482,
-0.0011856537,
-0.029835725,
-0.01797414,
-0.017112458,
-0.014958254,
-0.019428227,
0.00023182937,
0.014406239,
-0.03441341,
0.021003488,
-0.012676144,
-0.021636287,
0.028597059,
-0.0011705069,
0.013558022,
-0.020922706,
0.027950797,
0.016735472,
0.0014145379,
-0.032097638,
-0.0037059041,
0.0073310253,
0.0027331463,
0.023036519,
0.004493535,
-0.019549401,
-0.021488184,
-0.017799111,
0.014850544,
-0.032716975,
-0.027129507,
0.01983214,
0.010387302,
-0.00082129025,
0.0076945475,
-0.0104815485,
-0.02050533,
0.0021912293,
-0.014500486,
0.004180502,
0.0029603476,
-0.0055437093,
-0.033336308,
0.032232277,
-0.020155272,
0.015012109,
0.023588534,
-0.021770924,
-0.011188397,
-0.014204282,
0.0042141615,
0.027654594,
0.013537826,
0.023521215,
-0.014931327,
0.0014010741,
0.00727717,
0.0071358006,
-0.001130957,
0.006277485,
-0.01384076,
0.04294944,
0.014204282,
0.005143162,
0.006691496,
0.02660442,
-0.010548867,
-0.0078628445,
-0.022134446,
-0.025648491,
-0.04715014,
0.008105192,
0.04539985,
0.012292426,
-0.009619867,
0.012830977,
-0.014258138,
-0.00031745055,
-0.014244674,
-0.017826037,
-0.006136115,
-0.03231306,
-0.019185878,
0.011922172,
0.026564028,
0.014608196,
-0.006092358,
-0.0034500924,
-0.0014524047,
0.012393405,
-0.01494479,
0.04057982,
0.012575165,
0.017125921,
-0.029189464,
0.010239201,
-0.007243511,
-0.04814646,
-0.003298625,
-0.005096039,
-0.026833303,
-0.008973606,
-0.0133224055,
0.008939946,
-0.013436847,
0.0026792912,
0.011935636,
-0.00023351234,
0.010043976,
0.010690237,
0.0042680167,
0.006698228,
-0.004961401,
-0.013234891,
-0.004594513,
-0.018270342,
0.017570226,
0.021892099,
-0.010993172,
0.006560224,
-0.004799836,
-0.009390983,
-0.013827297,
0.020101415,
-0.01730095,
-0.018485762,
-0.030481987,
-0.008731258,
-0.0076204967,
0.015106356,
0.010299788,
-0.027923869,
-0.00952562,
0.015685298,
-0.019791748,
0.01844537,
-0.027923869,
-0.016748937,
-0.002815612,
-0.030131929,
-0.029620305,
0.010676773,
-0.045345996,
0.024921447,
0.024194403,
-0.0035813642,
-0.019562865,
0.010468085,
-0.040822167,
-0.02236333,
-0.023049982,
0.023198085,
0.003113498,
0.0035544366,
-0.0046382705,
0.024867592,
-0.0089803375,
0.010905658,
0.015739152,
-0.011827926,
0.0057120067,
-0.0049142777,
0.020559184,
0.0030596429,
-0.027708448,
-0.029162535,
0.02011488,
-0.008307149,
0.0038068823,
0.008993802,
-0.009653526,
0.03142445,
0.0015432852,
0.02422133,
0.026496708,
0.013006006,
0.04052596,
-0.041495353,
0.006338072,
0.009727578,
-0.014298529,
-0.0030394471,
-0.0040828898,
-0.026038941,
-0.015793009,
-0.0067318873,
0.0060216733,
-0.011080687,
0.02478681,
0.006088992,
0.012204912,
0.0030646918,
-0.006863159,
0.03374022,
0.03255541,
0.007250243,
0.009357324,
0.0013539508,
-0.00019154324,
-0.004836861,
-0.0018428542,
-0.002983909,
0.01587379,
-0.018014532,
0.014419703,
-0.02521765,
-0.0020145173,
0.0066713006,
-0.005149894,
-0.004846959,
0.04130686,
0.00068118284,
-0.010010317,
-0.008145584,
-0.007425272,
-0.02364239,
-0.028246999,
-0.010777752,
-0.017785646,
-0.0071963877,
-0.012763659,
0.022484504,
-0.0053114593,
-0.0089332145,
0.02621397,
-0.043649558,
0.0038674693,
0.0062068,
0.18213795,
-0.008044605,
-0.014150428,
0.009330396,
0.018660791,
0.0073242937,
0.0035342409,
-0.0056413217,
-0.0042343573,
0.013106985,
0.020666894,
0.0020515427,
-0.008024409,
-0.0052205785,
0.012925223,
-0.009290005,
0.0072839023,
-0.010017049,
-0.020464938,
-0.026792912,
0.008509106,
-0.0054730247,
0.020774605,
-0.009316932,
0.01697782,
-0.0064727096,
-0.010313252,
0.016775863,
0.028435493,
0.013504166,
-0.01227223,
0.02422133,
-0.010804679,
0.016291168,
0.0012605459,
-0.013261818,
-0.024706027,
-0.011848122,
0.015416022,
-0.00036373228,
-0.0048032016,
-0.019158952,
-0.018418444,
0.0075127864,
-0.012676144,
0.031451378,
0.001438941,
-0.0009508791,
-0.018566545,
0.012191448,
-0.022147909,
0.027008332,
0.014042717,
0.004119915,
-0.01647966,
0.003409701,
0.004964767,
0.031801436,
-0.00017387203,
0.025459997,
-0.012326086,
-0.0022972566,
-0.011262448,
0.013349333,
-0.02147472,
-0.008340809,
-0.018431908,
-0.034817323,
-0.0031437913,
-0.0100507075,
0.014002326,
-0.018930068,
0.006506369,
0.009781432,
-0.00062017515,
-0.017435588,
0.012979079,
0.028489348,
0.0009205856,
0.00909478,
0.009707382,
-0.0038203462,
-0.037725497,
-0.00048553737,
-0.022444112,
-0.0414415,
0.0042781145,
0.023117302,
-0.009081316,
-0.029324101,
-0.003404652,
-0.011457672,
-0.015200602,
-0.0036554148,
0.03810248,
0.0007581788,
-0.007896504,
0.01637195,
0.0021945953,
-0.0030562768,
-0.017893357,
0.08013639,
0.006566956,
0.0070819454,
0.011599042,
0.016829718,
-0.027762303,
0.017408662,
-0.019872531,
0.0049883286,
-0.011437477,
-0.012420332,
0.0075599095,
-0.02835471,
-0.02257875,
0.015133283,
0.004607977,
-0.028327782,
0.01390808,
-0.011195129,
-0.002273695,
-0.016802792,
-0.00443968,
0.033040103,
-0.0011477869,
-0.00322794,
-0.020007169,
0.015469877,
-0.0167624,
-0.023521215,
-0.008051338,
-0.008812041,
0.00021563077,
0.0041030855,
0.010468085,
0.027560348,
-0.008212903,
0.015860327,
-0.012918492,
0.019737894,
-0.011302839,
0.0069809672,
0.033309378,
0.004311774,
0.016587371,
-0.01326855,
0.017247096,
-0.0012984128,
-0.0116461655,
-0.024638709,
-0.016331559,
-0.015496805,
0.0128915645,
-0.0028206608,
0.023763563,
-0.0069069164,
-0.005186919,
-0.026187042,
0.008199438,
-0.013625341,
-0.005856742,
0.0124607235,
0.023548143,
-0.022484504,
0.0040492304,
-0.02346736,
-0.1699667,
-0.0048166653,
0.01905124,
-0.03363251,
0.009491961,
0.014163891,
0.016560443,
-0.0030663747,
-0.0065736882,
0.007351221,
0.03702538,
0.005146528,
-0.005328289,
-0.0009971608,
0.009895874,
-0.010542136,
0.0048200316,
0.05398974,
0.003652049,
0.03131674,
0.043030225,
0.002988958,
0.017166313,
-0.0327439,
0.013066594,
-0.013638804,
0.029539522,
-0.0039381543,
-0.025594637,
-0.024113622,
-0.030131929,
-0.0033036738,
0.0015045769,
0.0065097352,
-0.011558651,
-0.01380037,
-0.018229952,
-0.025096476,
0.006755449,
0.023426969,
0.030966682,
0.025163796,
0.00895341,
-0.032393843,
-0.0011402135,
0.031478304,
-0.008105192,
-0.02240372,
0.036325265,
-0.019172415,
0.015793009,
-0.010111295,
0.0019371007,
0.028327782,
0.03309396,
0.03099361,
0.024154013,
0.018404981,
-0.0012841076,
-0.007835917,
0.0009399398,
0.016425805,
0.01159231,
0.018566545,
0.0012588629,
-0.0186204,
0.010468085,
-0.0031555723,
-0.02500223,
0.00406606,
-0.044915155,
-0.024692563,
0.008105192,
-0.004947937,
0.022376794,
0.010979708,
-0.024207868,
0.0007081104,
-0.010043976,
0.030939754,
-0.0026523636,
0.022444112,
-0.0017856332,
-0.024490606,
-0.0025631662,
0.018135704,
0.0012748512,
-0.0020229323,
0.012568434,
-0.008791845,
0.014150428,
-0.032043785,
-0.012050078,
-0.0077349385,
0.014527413,
0.026348608,
-0.018162632,
-0.023898201,
-0.0061327494,
-0.0018933433,
0.028758623,
-0.026981404,
-0.029835725,
-0.0117740715,
0.024019374,
0.005621126,
-0.008919751,
0.00741854,
0.05681713,
-0.012817514,
0.004540658,
-0.02240372,
0.0066578365,
0.0029620305,
-0.027977724,
0.014352384,
0.011504795,
-0.008711062,
0.007357953,
-0.034790393,
0.045642197,
0.020801533,
0.01455434,
0.045561414,
0.0061327494,
-0.013113717,
-0.12860598,
-0.008091729,
-0.018876212,
0.021676678,
-0.024557926,
0.01858001,
-0.0076339603,
0.015577587,
-0.030105,
0.014298529,
-0.0022013271,
-0.020788068,
0.004560854,
-0.0055336114,
0.012373209,
-0.004958035,
0.005462927,
0.008125388,
-0.026523637,
0.019239735,
-0.016143067,
-0.005267702,
0.0019842237,
0.001407806,
-0.014527413,
0.03592135,
-0.027102578,
0.022686461,
0.019993706,
0.036621466,
0.00668813,
0.01747598,
0.00788304,
-0.009963193,
-0.011679824,
-0.016614297,
0.020478401,
-0.03220535,
0.036809962,
-0.02086885,
0.014150428,
0.012898296,
0.013921543,
-0.0047964696,
-0.013490702,
-0.003934788,
-0.037052307,
0.009397714,
-0.0048671546,
-0.018741574,
-0.027843086,
-0.029539522,
-0.008711062,
-0.011982759,
0.02485413,
-0.02422133,
0.0029149072,
0.015281385,
0.0016594103,
-0.004840227,
-0.007593569,
-0.0020532256,
-0.013988862,
-0.005701909,
0.02813929,
-0.024302114,
-0.0062572896,
-0.03769857,
0.011242252,
-0.008569692,
-0.0026086064,
-0.00549322,
-0.0068530613,
0.0028038311,
-0.014365848,
-0.0017654374,
-0.00887936,
0.01098644,
-0.0014136963,
-0.021905562,
-0.01594111,
-0.0186204,
0.028327782,
-0.02803158,
0.0070954096,
-0.0053484845,
0.011659629,
-0.0016047136,
0.018916603,
-0.025379216,
-0.012292426,
0.03263619,
-0.008529302,
-0.01384076,
-0.014110036,
0.024813738,
0.01073736,
0.0034534582,
0.018054921,
0.0167624,
-0.016129602,
-0.023090374,
-0.048631154,
0.014042717,
0.02361546,
0.005547075,
-0.0097948965,
-0.016560443,
0.001977492,
-0.014487022,
0.011780803,
0.0053754123,
-0.015819935,
0.007822453,
-0.013423383,
-0.00232755,
-0.013234891,
-0.009619867,
0.032232277,
0.0033911883,
0.015739152,
0.016883574,
0.0019539304,
-0.004136745,
0.005567271,
0.0037227338,
0.0022602312,
0.0012075324,
-0.0070684818,
0.02632168,
-0.012972347,
-0.006933844,
-0.011794267,
-0.05253565,
-0.0014683929,
0.008327344,
0.0054124375,
0.0060082097,
0.0089803375,
0.023332722,
0.009680454,
0.033363234,
0.009956461,
-0.03376715,
0.026523637,
-0.018351125,
0.007721475,
-0.00037782718,
-0.0350866,
-0.0028627352,
0.004974865,
-0.013685927,
0.023830881,
0.0037530272,
0.0021188615,
-0.033228595,
-0.023117302,
-0.012682876,
0.0052003833,
-0.0043790927,
0.005324923,
-0.022484504,
0.019697502,
0.03139752,
0.00093657384,
-0.0016215434,
-0.0056076623,
-0.040175904,
-0.0042343573,
0.019912923,
0.0031942807,
-0.02179785,
-0.045319065,
0.0033356503,
0.023049982,
0.011612506,
-0.006523199,
-0.007129069,
-0.02593123,
-0.005930793,
-0.018647328,
0.018216487,
0.010010317,
-0.003298625,
-0.021743996,
0.04012205,
0.028193144,
-0.0067958403,
-0.0036722445,
0.03689074,
0.0010636383,
0.016560443,
-0.0038203462,
0.013679195,
0.016385414,
-0.0028273927,
0.030293493,
0.037860136,
-0.0030142027,
0.016169993,
0.013046398,
0.028193144,
-0.01814917,
0.026671737,
0.011996224,
-0.0015205651,
-0.020814996,
0.019320518,
-0.029162535,
-0.02703526,
-0.025177259,
-0.0027954162,
0.01844537,
0.0078628445,
-0.0021777656,
0.008993802,
0.010158418,
0.008004215,
-0.00073587947,
0.0041468428,
-0.0030646918,
0.012103934,
0.0013783539,
0.0067891083,
0.0076878155,
0.006641007,
-0.003229623,
0.015065964,
0.043245643,
-0.031586017,
0.03032042,
-0.03032042,
-0.0062539233,
0.0060082097,
-0.011888513,
-0.009942998,
0.00014147483,
-0.019549401,
0.0064861737,
0.026941013,
-0.03470961,
0.08681442,
0.018526154,
-0.008408127,
-0.019885996,
-0.0008553704,
0.019199343,
0.021097735,
0.006200068,
-0.013046398,
-0.03406335,
0.013975399,
-0.020922706,
0.0007472395,
-0.027075652,
-0.0221883,
0.04440353,
0.014527413,
0.019791748,
-0.004426216,
-0.016708545,
0.005940891,
-0.0062976805,
0.0026776083,
0.02789694,
-0.026739057,
-0.0211112,
0.019980242,
-0.00043883492,
-0.013470506,
-0.016829718,
-0.01376671,
-0.010508476,
-0.030293493,
0.0021878635,
0.004365629,
-0.00442285,
-0.012043347,
-0.029916508,
-0.009788164,
0.026160115,
0.0026540465,
0.022834562,
-0.015968038,
-0.026079332,
-0.007472395,
-0.0060822605,
-0.010871998,
-0.014675515,
-0.008650475
] |
The basic biology of the cell division cycle and its control by protein kinases was originally studied through genetic and biochemical studies in yeast and other model organisms. The major regulatory mechanisms identified in this pioneer work are conserved in mammals. However, recent studies in different cell types or genetic models are now providing a new perspective on the function of these major cell cycle regulators in different tissues. Here, we review the physiological relevance of mammalian cell cycle kinases such as cyclin-dependent kinases (Cdks), Aurora and Polo-like kinases, and mitotic checkpoint regulators (Bub1, BubR1, and Mps1) as | [
-0.010915331,
-0.024580775,
0.0060829883,
-0.024711732,
-0.02459387,
0.01752215,
-0.013049942,
0.024764115,
-0.012355866,
-0.03370853,
0.030644119,
-0.008689049,
0.012074307,
0.008505708,
-0.011517736,
0.013449363,
0.034965724,
-0.012480276,
-0.0057916073,
0.014942282,
-0.021843756,
0.025261754,
-0.0030234875,
-0.044866133,
-0.0034474633,
0.026479661,
0.0011123226,
-0.029098818,
0.0005467487,
-0.034939535,
-0.0076217423,
-0.011249273,
0.0054543912,
0.0004354346,
0.006921118,
-0.011858227,
0.030198863,
-0.011340943,
0.010456978,
-0.001116415,
0.006371096,
0.020822287,
-0.0077527002,
-0.0245022,
-0.0042004706,
0.020193689,
0.025170084,
-0.004269223,
-0.014091057,
0.026898727,
-0.007111007,
0.0056082667,
-0.0032297461,
-0.0043576197,
-0.026152268,
-0.02255093,
-0.010522457,
0.009042635,
-0.0101950625,
-0.017574534,
-0.017836448,
0.0040269517,
-0.0014765488,
0.005274324,
0.014562504,
0.008990251,
0.008937868,
0.009284906,
0.01423511,
-0.01280767,
0.034677617,
0.0052121193,
-0.0091474,
0.010352212,
0.019263888,
-0.02865356,
-0.03740154,
-0.012945176,
-0.016291147,
0.024292666,
0.004400181,
0.007307444,
0.011674886,
0.022289013,
0.0023064937,
-0.005156462,
0.018988878,
-0.004688288,
0.014444643,
0.012375509,
-0.0034278198,
0.020311551,
0.023375962,
0.014418451,
-0.019172218,
0.0026846344,
-0.0012138148,
0.01618638,
-0.01246718,
-0.010123036,
-0.0011638872,
0.02595583,
0.011498093,
-0.01636972,
-0.043006532,
0.00087168766,
0.016317338,
-0.02316643,
0.011949897,
-0.0008594104,
-0.028234497,
0.035122875,
0.00483889,
-0.04198506,
0.044211343,
-0.013311857,
-0.0040269517,
0.0027910376,
-0.011026644,
-0.00566065,
0.02375574,
0.0143005885,
0.036511026,
-0.03179655,
0.034441896,
-0.007765796,
0.00059176545,
0.021503266,
-0.0074318536,
-0.0020314825,
-0.002774668,
0.0006682939,
-0.017495958,
0.03300136,
-0.013920811,
-0.010070653,
-0.008885485,
-0.006777065,
0.0032690335,
-0.027055876,
0.004825794,
0.027082067,
-0.02316643,
0.018438855,
-0.004301963,
0.015701838,
0.020940147,
0.0102867335,
-0.0027321065,
0.004252854,
0.005742498,
-0.009500986,
0.031429864,
0.014222014,
0.012925533,
0.013069586,
0.0010550285,
0.009775998,
-0.012545754,
-0.0121594295,
0.014929187,
-0.0064889574,
0.013226735,
-0.0052317632,
0.03483477,
0.025916543,
0.02518318,
0.0143922595,
-0.00094371446,
-0.010077201,
0.0022148234,
0.011602859,
-0.02105801,
0.013462459,
-0.041958872,
0.005077888,
-0.018648386,
0.019185314,
-0.04078025,
0.00044648416,
-0.006456218,
0.012440989,
0.02341525,
0.0057163066,
-0.011648694,
0.0014315322,
0.017456671,
-0.01836028,
0.016906649,
-0.011792747,
-0.011524284,
0.0028074072,
0.006119002,
-0.024292666,
-0.6323689,
-0.010011721,
0.0010214706,
-0.013292214,
0.011124862,
0.031089375,
0.02561534,
-0.0033754366,
-0.016631637,
0.012663617,
-0.005228489,
0.011229629,
0.022210438,
-0.039051607,
-0.036065772,
-0.043085106,
-0.018517429,
-0.023022376,
0.030460779,
-0.013580321,
-0.017260235,
0.005755594,
-0.016579254,
0.02831307,
0.007111007,
0.015793508,
0.033210892,
0.0011049563,
0.01035876,
0.06841234,
-0.019172218,
0.009075373,
-0.028732136,
0.0136327045,
0.03237276,
0.0056180884,
-0.00024411347,
-0.0007513702,
-0.0021051462,
0.042142212,
-0.012349318,
-0.002416171,
0.03116795,
0.00800152,
-0.008950964,
0.0076217423,
0.01636972,
-0.005077888,
0.0048487117,
0.020154402,
-0.0016287873,
0.006842544,
-0.0036799135,
0.015020857,
0.007759248,
0.018582908,
0.030853651,
-0.015099431,
0.008427133,
0.016212571,
0.002110057,
0.011471901,
-0.02862737,
-0.023389058,
-0.016998319,
0.017823353,
-0.012545754,
0.0029285431,
-0.0056213625,
0.0025062044,
0.011786199,
0.0015043775,
-0.010587936,
-0.02198781,
-0.007052076,
0.022524737,
0.026034405,
0.0017433753,
0.005546062,
0.010568292,
0.0013717826,
-0.016710212,
-0.023375962,
-0.0073205396,
0.018334089,
-0.015125623,
-0.009998626,
0.01246718,
0.01153738,
0.008381298,
0.01128856,
-0.022158055,
-0.010489718,
-0.023808124,
-0.035699088,
0.03768965,
-0.0005058244,
0.0053234333,
-0.0031462605,
-0.054164134,
-0.007523524,
0.0056835674,
-0.022459257,
-0.005094257,
0.015047048,
0.005221941,
-0.024751019,
0.0013063038,
0.057149973,
-0.018779345,
0.0032755814,
0.0033296014,
0.009370029,
-0.0021804469,
0.01516491,
-0.02570701,
0.020285359,
0.031613205,
-0.00024288574,
0.003653722,
0.005817799,
-0.005886552,
0.011727269,
-0.02425338,
0.01752215,
0.012015375,
-0.008289627,
-0.013180899,
-0.00089051283,
0.0074318536,
0.010928426,
0.0064365747,
0.034258552,
-0.023742644,
0.010948069,
0.00038264223,
0.020822287,
0.0027222848,
0.022616407,
-0.016854266,
-0.027867815,
-0.020141305,
-0.008950964,
-0.0024603691,
-0.005415104,
-0.014418451,
-0.03585624,
0.014156535,
0.013724375,
0.0041808267,
0.002231193,
-0.004753767,
-0.004901095,
0.0135410335,
0.0186091,
0.00483889,
-0.031220334,
-0.012368961,
0.0049141906,
-0.0064431224,
0.0097956415,
-0.00837475,
-0.04586141,
0.009618849,
-0.006046975,
-0.0075759073,
0.0080997385,
-0.006338356,
0.0052481326,
-0.03273944,
-0.0024210818,
-0.009717067,
-0.03913018,
0.02105801,
0.023729548,
-0.0002615063,
0.004400181,
-0.011661789,
-0.019159121,
-0.0030447682,
0.0027992225,
-0.035777662,
-0.020246072,
-0.011694529,
0.032634676,
0.026715385,
0.042875573,
0.0020985983,
-0.0068687354,
0.037296772,
0.00042806822,
0.0135410335,
0.0077396045,
0.00566065,
0.016762596,
-0.028941669,
-0.009605752,
0.002756661,
0.0029023516,
0.025196275,
0.029072626,
-0.02645347,
0.011406422,
-0.026846344,
0.0017482863,
-0.03823967,
-0.011976088,
-0.004933834,
0.012879697,
0.010751633,
-0.0022164604,
0.0052153934,
-0.00964504,
-0.005948757,
0.008368202,
0.001645157,
-0.0012743828,
-0.01069925,
-0.025759393,
0.0020855025,
-0.006128824,
-0.014287493,
0.01808527,
-0.0071895816,
-0.00043707158,
0.02124135,
-0.0005201479,
0.037192006,
0.006112454,
0.009225975,
-0.02155565,
0.01870077,
-0.016723307,
0.01919841,
0.007458045,
0.011943349,
0.003169178,
-0.0077330563,
0.040885016,
-0.008335462,
0.005225215,
0.008427133,
-0.010673058,
-0.0018694223,
0.006524971,
-0.0036995572,
0.0223283,
0.002295035,
-0.014169631,
0.0058963737,
0.0010149227,
0.0010173782,
-0.022839036,
0.0068229,
0.011930253,
-0.021621129,
0.011079027,
0.0036439,
0.027343983,
0.008571186,
-0.011655242,
-0.013580321,
-0.003111884,
-0.021372309,
-0.008021164,
0.00830927,
0.024672445,
-0.014667271,
-0.03996831,
-0.0029236323,
-0.015269676,
0.022786653,
0.018740058,
-0.006809804,
0.036982477,
-0.00034928892,
0.009324193,
-0.0007824727,
0.010561745,
0.008918224,
-0.011347491,
-0.023061663,
-0.0018956137,
0.03281802,
-0.010378404,
-0.012100498,
-0.024515295,
-0.013174352,
-0.015335156,
0.0048749032,
-0.013842236,
0.0057392246,
-0.012165977,
-0.014981569,
-0.024868881,
-0.039994504,
0.017076893,
-0.0013881524,
0.019827006,
0.0076872213,
0.00030775077,
0.007700317,
-0.008669404,
-0.009579561,
0.03889446,
0.0024832867,
0.0048454376,
-0.020416318,
-0.0061550154,
-0.037008666,
-0.00096745056,
-0.009324193,
-0.00054142857,
-0.023493825,
0.0014176179,
0.005942209,
0.033263274,
-0.00070307957,
0.021765182,
0.006063345,
-0.01981391,
0.0041971966,
0.008453324,
-0.0072223214,
0.045180432,
0.023860507,
0.007962232,
0.03355138,
-0.0042561274,
-0.011465353,
-0.0176793,
-0.018740058,
0.0431113,
-0.022590216,
-0.024855785,
-0.017653108,
-0.0029252693,
-0.0121594295,
0.0056737456,
0.012323126,
-0.0019741885,
0.0040302253,
-0.004992765,
0.014785132,
0.021228256,
-0.00017454216,
0.05694044,
0.033210892,
0.019931773,
0.0068818307,
0.014667271,
0.049763955,
-0.01187787,
-0.0060207834,
-0.011209985,
0.021503266,
0.0008896944,
0.011962992,
-0.009311098,
-0.013658896,
0.014968473,
0.018098364,
0.0062532336,
0.00612555,
0.014654174,
0.010129584,
0.0040989784,
-0.0032690335,
0.0036340782,
-0.009756354,
0.029544074,
0.009625397,
-0.011570119,
-0.020769903,
0.019303177,
-0.019001972,
0.0012408249,
-0.028705943,
0.018910302,
-0.010659963,
0.008440228,
-0.008459873,
-0.01060758,
0.003823967,
-0.00883965,
-0.012493372,
0.0050844355,
-0.01082366,
0.002064222,
0.009153948,
-0.0034474633,
-0.026780864,
-0.034468085,
-0.02425338,
0.0059291134,
-0.04109455,
-0.01919841,
-0.019316271,
0.03617054,
0.028679753,
0.0145756,
-0.024043847,
-0.024633158,
0.035149068,
-0.0046162615,
-0.0039058155,
-0.011052836,
-0.033918064,
-0.03740154,
0.009730162,
0.012598137,
-0.00013198088,
0.0038763501,
0.002353966,
0.003007118,
0.006567532,
0.013671991,
-0.020835381,
-0.01795431,
0.022747366,
0.0120677585,
0.044708982,
-0.0016279689,
-0.01032602,
-0.0038861718,
-0.003526038,
-0.026374895,
-0.008394393,
-0.008472968,
-0.006940762,
-0.013711279,
0.017967407,
-0.0053430772,
0.002828688,
-0.0058145253,
-0.0126046855,
0.0071961298,
-0.005012409,
0.007405662,
0.019080548,
0.015125623,
0.016788786,
-0.004174279,
-0.021935428,
0.004056417,
-0.0044427426,
0.032765634,
0.0075759073,
-0.033499,
0.017325714,
-0.0167495,
-0.015583975,
-0.022996185,
-0.003532586,
-0.004337976,
0.047563862,
-0.0010190152,
-0.03585624,
-0.0020756808,
-0.004901095,
-0.007602099,
0.0056082667,
0.0033787105,
-0.004707932,
-0.0044885776,
0.0022361039,
0.038475394,
-0.027579706,
0.0135410335,
-0.042377934,
-0.008289627,
0.02074371,
-0.005726129,
0.015112527,
-0.006227042,
0.005647554,
-0.020259168,
-0.00989386,
-0.0009813649,
-0.06060726,
-0.0012408249,
0.0029743784,
0.024528392,
0.03920876,
0.030356012,
-0.00040433212,
0.004609714,
0.020075826,
0.021568745,
-0.0050255046,
-0.015335156,
0.0135410335,
-0.02744875,
0.02099253,
-0.015204198,
-0.006371096,
0.011517736,
-0.0076413862,
0.0045573306,
0.025143892,
-0.0019005247,
-0.03826586,
-0.0035194901,
-0.017338809,
-0.028051155,
0.009376576,
-0.03179655,
-0.02099253,
-0.017941214,
-0.013894619,
0.02592964,
0.0076151947,
0.012722548,
-0.014457738,
0.011687981,
-0.034939535,
0.010758181,
-0.009867668,
0.0269773,
-0.025287947,
-0.014955378,
-0.020521084,
-0.003873076,
0.025143892,
0.015439921,
0.026898727,
0.0058505386,
-0.0012400064,
-0.007569359,
0.012585042,
-0.022197343,
-0.018884111,
-0.0068687354,
-0.03996831,
-0.025851065,
0.0008725062,
-0.017365001,
-0.02797258,
0.0010943159,
0.008924772,
-0.023637878,
0.017168565,
0.0012481912,
-0.0026748125,
0.050130635,
-0.0027452023,
0.020272262,
-0.0019185314,
0.016107807,
0.0071961298,
0.006921118,
-0.013802949,
-0.032477528,
-0.018530525,
0.00039185022,
0.028705943,
0.028339261,
-0.0051008053,
-0.011583215,
0.003296862,
0.004979669,
-0.025824873,
-0.033106126,
-0.006888379,
0.0059061954,
0.0008700507,
0.016985223,
-0.0038567064,
0.0015223841,
0.0056213625,
0.0010542101,
0.010090296,
0.0056180884,
-0.020350838,
-0.010365307,
0.030932225,
-0.0017122729,
0.006757421,
0.005889826,
-0.02595583,
0.023205718,
-0.0025176632,
-0.011079027,
-0.009219428,
-0.015570879,
0.010188514,
-0.010345664,
-0.0027304695,
0.016304243,
-0.016068518,
0.007058624,
-0.015439921,
-0.0010795832,
0.045416154,
-0.0022361039,
0.009690875,
0.0005884915,
0.002183721,
0.0006871191,
-0.008361653,
-0.009343837,
-0.0106861545,
-0.022747366,
0.008970607,
0.019250793,
0.035672896,
-0.002877797,
-0.00952063,
-0.036825325,
0.0013455912,
-0.012624329,
-0.01650068,
0.0014323506,
-0.048637718,
-0.00908847,
0.001586226,
0.021097297,
0.008603926,
-0.0035653254,
-0.008106286,
-0.006344904,
0.039287332,
-0.0035162163,
0.018687675,
0.0036177086,
-0.029753607,
-0.035568133,
0.0036177086,
-0.013370789,
-0.02298309,
0.0057326765,
-0.011295108,
-0.021162776,
0.00353586,
-0.00037077419,
0.024580775,
0.006361274,
0.0001112118,
0.019106738,
0.016854266,
0.02248545,
0.0057948814,
-0.012945176,
-0.0062532336,
-0.02964884,
-0.017050702,
0.023310484,
-0.01969605,
-0.01507324,
-0.015466113,
-0.03559432,
-0.0015968663,
-0.004694836,
-0.015361346,
-0.034965724,
-0.0092587145,
0.0056246365,
0.013410076,
-0.010601032,
-0.013947003,
-0.02155565,
0.019185314,
0.021097297,
-0.002522574,
-0.012434441,
-0.0011794384,
0.005713033,
0.0151911015,
-0.018425759,
-0.0040957043,
0.009265263,
-0.02393908,
-0.03001552,
-0.0042037447,
-0.037584882,
0.04282319,
0.00010466391,
0.0067312294,
-0.030879842,
0.0048552593,
-0.029544074,
-0.02595583,
0.00905573,
0.010123036,
-0.002538944,
0.006246686,
0.005192476,
-0.0016582528,
-0.0011237814,
0.021254446,
-0.0026584428,
-0.014601791,
0.023245005,
0.004865081,
0.011511188,
-0.018543622,
-0.014929187,
-0.013829141,
0.019512707,
-0.028260687,
0.0030791447,
0.02298309,
-0.02427957,
0.024659349,
0.0011606133,
-0.0027157369,
0.011367135,
0.03590862,
0.023375962,
-0.022040194,
-0.021162776,
0.017666204,
-0.002525848,
-0.020481795,
0.004576974,
-0.0061026323,
-0.016317338,
0.03640626,
-0.023336675,
-0.01938175,
0.017011415,
-0.009939695,
0.024921264,
0.021071106,
0.005703211,
0.020625848,
0.0058145253,
-0.02744875,
-0.009370029,
0.0021984535,
-0.021503266,
0.0008062088,
-0.0060371533,
0.0049567516,
0.016147094,
-0.0018988877,
-0.005451117,
-0.02797258,
-0.01956509,
0.007111007,
0.0025405807,
-0.037532497,
0.025104605,
0.002887619,
-0.010064105,
-0.029229775,
0.010411143,
-0.0038665282,
-0.014601791,
-0.0043281545,
0.0022655695,
-0.026492758,
0.014654174,
-0.00014098422,
-0.012454084,
0.030801268,
-0.0032101024,
-0.007058624,
-0.034965724,
0.012198716,
0.18135032,
-0.0066133677,
0.0032461158,
0.019735336,
-0.0038698022,
-0.02074371,
0.0033590668,
-0.0025667723,
-0.010705798,
-0.009121208,
0.010679606,
0.0061910287,
-0.021843756,
-0.0031937326,
0.015439921,
-0.0028090442,
-0.011884418,
-0.0011687981,
-0.007294348,
0.017640011,
0.006711586,
-0.01904126,
0.012643973,
0.009933147,
0.04064929,
-0.0013169441,
-0.027736856,
0.0026257033,
-0.0018284979,
0.0009993715,
-0.028365454,
0.016382817,
-0.00564428,
0.005591897,
0.0075497157,
0.00576869,
-0.008459873,
-0.015426826,
0.020259168,
-0.012768383,
0.011589763,
-0.005703211,
0.011838582,
-0.004586796,
0.0026404362,
0.025562957,
0.0000014019771,
-0.011635598,
0.013711279,
-0.00517938,
-0.06537412,
0.016605446,
0.0091474,
0.023965273,
0.013711279,
-0.00505497,
0.00896406,
0.0047308495,
0.0020151127,
0.027684473,
-0.02459387,
-0.018831728,
-0.020927053,
0.0039581987,
-0.013049942,
0.0059585785,
-0.018059077,
0.0053627207,
0.028260687,
-0.039654013,
-0.026257034,
0.019827006,
-0.017050702,
-0.01175346,
0.007949137,
-0.0066690245,
0.03234657,
0.02518318,
0.020979436,
0.0136327045,
-0.017404288,
0.0192246,
-0.02554986,
-0.008924772,
0.0068490915,
-0.019303177,
0.043713704,
0.008682501,
-0.0035129422,
-0.011786199,
0.0076872213,
-0.00889858,
-0.013580321,
-0.0029481868,
0.0076413862,
-0.0016173285,
-0.012585042,
0.0024423625,
-0.007228869,
-0.025353424,
-0.029020242,
0.07134579,
0.024043847,
0.006524971,
0.00020472384,
0.0040695127,
-0.0040367735,
0.0154137295,
-0.017194755,
-0.03913018,
0.0019201683,
-0.014025577,
0.007916397,
-0.0060404274,
-0.022694983,
0.0061910287,
0.024790306,
-0.028155921,
0.030382203,
-0.013776758,
-0.010666511,
-0.034991916,
0.0050320523,
0.027579706,
0.0022066385,
0.014444643,
-0.022681886,
-0.00025925547,
-0.00716339,
-0.017784066,
-0.016133998,
-0.010371855,
0.0020904134,
0.023899794,
0.00090197165,
-0.023061663,
0.02307476,
-0.01141297,
0.0076610297,
0.005870182,
-0.00058398984,
0.029203583,
-0.013881524,
0.003470381,
0.010260542,
-0.0167495,
0.013933907,
0.037506305,
-0.03452047,
-0.024620062,
-0.007883658,
-0.014902995,
-0.007896754,
-0.025824873,
0.010031366,
-0.015374443,
-0.008427133,
-0.00880691,
0.010666511,
0.0032117395,
-0.0073991143,
0.011766556,
0.019159121,
-0.00017750917,
-0.0037257487,
0.0031069731,
-0.16291147,
-0.00750388,
0.017692395,
-0.011805844,
0.025078414,
0.017338809,
0.01057484,
0.0080080675,
0.004184101,
-0.0009772724,
0.027422559,
0.008649761,
-0.04381847,
-0.047563862,
0.0029874742,
0.002458732,
-0.012742192,
0.031246524,
0.013501747,
0.0034278198,
0.0272916,
-0.017692395,
0.015335156,
-0.012296935,
-0.0051040794,
0.020206785,
0.0022639325,
-0.009553369,
-0.006986597,
-0.029596457,
-0.012454084,
0.016330434,
0.0116225025,
-0.0008139844,
0.00083894824,
0.0066264635,
-0.008152122,
-0.01960438,
0.0000050324106,
0.0055722534,
0.016998319,
0.030565545,
0.015636358,
-0.0021493444,
0.030277437,
0.049449656,
-0.013737471,
0.004933834,
0.027736856,
-0.017653108,
0.040570717,
0.0016877183,
0.00038571155,
0.01820313,
0.028994052,
0.0145756,
0.0034867506,
0.00006834359,
-0.002825414,
-0.0019299901,
-0.004364168,
-0.011805844,
0.010096844,
-0.0070913634,
-0.0022279192,
-0.015872082,
-0.017325714,
0.018006694,
-0.028705943,
0.005094257,
-0.007111007,
0.008820006,
0.04261366,
-0.02468554,
0.02695111,
0.0011941711,
-0.0031544454,
-0.0019152574,
0.013514842,
0.0030873294,
-0.026414182,
0.026649907,
-0.03336804,
-0.02393908,
-0.015531592,
0.0029318172,
0.0015232026,
0.031429864,
-0.004593344,
0.0045049475,
0.023677165,
-0.018622195,
-0.022773556,
-0.015623262,
0.025968926,
0.014104152,
-0.022799749,
-0.027763048,
0.009160496,
0.0022000906,
0.021463979,
0.0068949265,
-0.020232975,
0.005595171,
0.03622292,
0.009042635,
-0.012991011,
0.00423321,
0.02568082,
0.003242842,
-0.0012138148,
-0.009291454,
0.0045213173,
0.018753152,
0.0030202137,
0.031063184,
0.0014961925,
0.011760008,
0.005880004,
-0.027789239,
0.08009377,
0.01817694,
-0.00043461611,
0.006177933,
0.00010517546,
-0.016945936,
-0.12687188,
-0.015112527,
-0.0017368274,
0.019617474,
-0.013711279,
0.004884725,
-0.020625848,
0.027946388,
0.0014094331,
0.038318243,
-0.030801268,
-0.0016860813,
-0.003873076,
0.014523217,
0.0009273447,
-0.009003347,
0.0025143893,
-0.019853199,
-0.0028090442,
0.008905129,
0.01048317,
-0.00019848287,
-0.011216533,
-0.0037192008,
0.01677569,
0.0063121645,
-0.027894005,
0.03048697,
0.01414344,
0.0069276663,
-0.0033885324,
0.000004706295,
0.0050909836,
-0.0055689793,
-0.014222014,
-0.019080548,
-0.0077527002,
-0.036851518,
0.03994212,
-0.004190649,
0.002813955,
0.013311857,
0.043870855,
-0.011858227,
0.024305763,
-0.009081922,
-0.015675645,
-0.007058624,
-0.0019823732,
-0.010391499,
-0.024620062,
-0.013802949,
-0.026518948,
-0.0068490915,
0.01752215,
-0.033394232,
0.012473728,
0.0107319895,
0.004943656,
-0.012768383,
-0.0010501177,
0.0050746137,
0.0029629197,
-0.0042495797,
0.01804598,
-0.01600304,
-0.029465498,
-0.03355138,
0.032110848,
-0.035096683,
-0.00056066294,
0.0003861208,
-0.018543622,
-0.001650068,
-0.013475555,
-0.0030955144,
-0.02577249,
-0.0057883337,
0.01507324,
-0.011419518,
-0.004167731,
-0.030879842,
0.00071658456,
-0.008472968,
0.0452852,
-0.003945103,
-0.003709379,
-0.011065932,
0.015819699,
0.0015199287,
-0.0044427426,
0.02536652,
0.0024472733,
-0.010614128,
0.005172832,
0.004832342,
0.0047275755,
-0.0031331647,
0.005546062,
0.040832635,
-0.024462912,
-0.008414037,
-0.052461684,
0.0210842,
0.007667578,
0.001172072,
0.010548648,
0.0023703356,
0.0017597451,
-0.0022688434,
0.017980503,
0.026898727,
-0.016893553,
0.017273331,
-0.006053523,
-0.009062278,
-0.036668178,
-0.020036539,
0.025890352,
-0.016173285,
0.00082953565,
0.01246718,
-0.004642453,
-0.001200719,
0.04921393,
0.0034867506,
-0.0010059194,
-0.0013439541,
-0.0036373523,
0.011229629,
0.00031839107,
0.004367442,
0.005300516,
-0.03407521,
-0.009134305,
0.0015665824,
-0.0062139463,
-0.03268706,
-0.0059782225,
0.035175256,
0.02350692,
0.045442346,
0.002702641,
-0.026872534,
-0.00030181673,
-0.008669404,
-0.0010894049,
0.0036831873,
-0.029020242,
0.011727269,
-0.013462459,
-0.02105801,
0.026676098,
0.013082681,
0.0008238062,
-0.04313749,
0.0034834768,
0.0055657052,
-0.010581388,
-0.01761382,
-0.015112527,
-0.033394232,
0.0014945556,
0.028051155,
0.022433067,
-0.02611298,
-0.006420205,
-0.0056541017,
-0.036982477,
-0.012794575,
-0.00494693,
-0.03693009,
-0.020154402,
0.023637878,
0.02384741,
0.0019070726,
-0.01448393,
-0.022249725,
-0.019263888,
-0.0051008053,
0.0013275844,
0.01792812,
0.02536652,
0.0128731495,
-0.007949137,
0.019997252,
0.029386925,
-0.01919841,
0.013606513,
0.014051769,
0.014457738,
0.009939695,
-0.017430479,
0.010149227,
0.017875737,
-0.00046735557,
0.014287493,
0.014745845,
-0.019591283,
-0.012349318,
-0.0052121193,
0.028548794,
0.0058145253,
0.0008577734,
0.0015297505,
-0.02400456,
-0.017469767,
0.021280639,
-0.030408395,
-0.0449709,
-0.02198781,
-0.013023751,
0.005117175,
-0.0053136116,
0.01659235,
-0.0074645933,
0.0007824727,
0.006223768,
-0.0006777065,
-0.0029105365,
-0.0017319166,
0.03622292,
0.009848025,
0.013351145,
-0.0011843494,
0.009671232,
0.0012571947,
0.0028385096,
0.012323126,
-0.012709452,
0.032765634,
-0.013881524,
0.014536313,
-0.0026060597,
-0.031508442,
-0.013148161,
-0.004583522,
-0.030434586,
0.013357692,
0.014614888,
-0.013567225,
0.078574665,
-0.00038714393,
-0.009461699,
0.015348251,
-0.013207091,
0.020062732,
0.0019234422,
0.0071437466,
-0.043189872,
-0.02341525,
0.0059684003,
-0.0123820575,
0.010601032,
-0.023140239,
-0.007949137,
0.039025415,
-0.017469767,
0.00058439904,
0.018465046,
-0.025968926,
-0.010555197,
-0.04143504,
0.0038305148,
0.028234497,
-0.005408556,
-0.005938935,
0.02865356,
0.009546822,
0.005221941,
-0.026846344,
0.019316271,
-0.028024964,
-0.033106126,
-0.0037715838,
0.003008755,
-0.004940382,
0.000039824463,
-0.010836756,
0.02763209,
0.009376576,
-0.021699702,
-0.029439308,
-0.014470834,
-0.012329674,
-0.007647934,
-0.0042102924,
0.0026944561,
-0.012336222,
0.006128824
] |
Human mesenchymal stem cells (MSCs) have increasingly been used as cellular vectors for the delivery of therapeutic genes to tumors. However, the precise mechanism of mobilization remains poorly defined. In this study, MSCs that expressed similar cell surface markers and exhibited multilineage differentiation potentials were isolated from various donors. Interestingly, different MSC isolates displayed differential migration ability toward human glioma cells. We hypothesized that distinct molecular signals may be involved in the varied tumor tropisms exhibited by different MSC isolates. To test this hypothesis, gene expression profiles of tumor-trophic MSCs were compared with those of non-tumor-trophic MSCs | [
-0.02835231,
-0.010870124,
0.0019578612,
-0.028978305,
-0.021388127,
0.0028756598,
-0.021022964,
-0.00023230245,
-0.035551243,
-0.020018766,
0.013145873,
0.005422021,
-0.011098351,
0.0034788311,
-0.014958648,
0.015180354,
0.037455305,
-0.004271105,
-0.02378777,
0.0016644266,
-0.02267924,
0.008490044,
-0.0001588419,
-0.010967936,
-0.0069837454,
0.024700679,
0.0068663713,
-0.036281567,
-0.0139544485,
-0.00795534,
0.0056567686,
0.0069185374,
-0.014189197,
0.0005840165,
-0.023200901,
-0.00786405,
0.016914878,
-0.011326578,
0.021779373,
0.00091616827,
0.0015209697,
0.0014671733,
-0.009539887,
-0.007981423,
-0.011359182,
0.0000048109787,
-0.005532874,
-0.023122652,
-0.005748059,
0.019836184,
0.03445575,
-0.013204561,
-0.02013614,
0.017879954,
-0.030073794,
-0.0062632,
0.009546408,
-0.003358197,
0.0036614127,
-0.016497549,
0.0056828517,
0.009435555,
-0.023983395,
0.017801704,
0.0036972768,
0.0024615908,
-0.0051937937,
0.0020198086,
0.019901391,
-0.008203129,
0.02360519,
0.005738278,
-0.0022610773,
-0.0015796566,
0.01227209,
-0.021088172,
-0.024674596,
-0.0041928557,
-0.010381066,
0.009246453,
0.009135599,
-0.029891212,
0.0057024136,
0.028221894,
0.0034560084,
0.034221005,
-0.005102503,
0.011222246,
0.0045580184,
-0.015754182,
0.022627074,
0.027569817,
-0.00080164726,
0.004975348,
0.008698707,
-0.003664673,
-0.0035570804,
0.023409566,
0.0055817794,
-0.029160885,
-0.009546408,
0.0233574,
-0.017919077,
-0.01759304,
-0.045880143,
0.0036744543,
0.01700617,
0.004359135,
0.029682547,
-0.011130955,
-0.017358292,
0.017645204,
-0.014463069,
-0.046219222,
0.02031872,
0.02098384,
0.016641006,
0.013367579,
-0.0014011506,
0.00059461273,
0.011450473,
0.0154672675,
0.0075966977,
-0.017945161,
0.024713721,
0.022353202,
-0.011470036,
0.012852439,
-0.021688083,
0.003909202,
0.0032359324,
-0.015519434,
0.0004804993,
0.009787677,
-0.013087186,
-0.007883611,
-0.00253821,
-0.0053307298,
-0.01945798,
-0.028404476,
-0.016275844,
0.024857176,
-0.00600563,
0.01684967,
-0.010694063,
-0.009448596,
0.035133913,
0.008085756,
0.013048062,
0.0075706146,
0.005653508,
-0.02513105,
0.015323811,
-0.002166526,
-0.008131401,
0.0029327166,
0.007140244,
0.000855036,
-0.024739804,
-0.012069946,
-0.0014859206,
-0.008561771,
0.01608022,
0.0002571629,
0.012311215,
0.026643869,
-0.005092722,
0.0019252575,
-0.0013074145,
-0.025496213,
-0.019679686,
0.022379285,
-0.028378394,
0.012650295,
-0.014789107,
-0.0041406895,
0.0027631766,
0.01759304,
-0.01904065,
-0.022314077,
-0.0042091575,
0.027856732,
0.01854507,
-0.005050337,
-0.007753196,
-0.011776512,
0.024518097,
-0.02072301,
0.009076913,
-0.031690944,
-0.015089063,
0.0017214834,
-0.002021439,
0.0036451106,
-0.6355925,
-0.038733378,
0.0064686043,
0.0057415385,
0.017032253,
0.034534,
0.010980978,
-0.020879507,
-0.03325593,
0.017332207,
-0.027048156,
0.016262801,
-0.008972581,
-0.020514345,
-0.020514345,
-0.015532475,
-0.005790444,
-0.026630826,
0.04848845,
0.01040715,
-0.02089255,
-0.0052916054,
-0.008398753,
0.025339715,
0.00069976016,
0.017319167,
0.02353998,
-0.0011818897,
-0.011196163,
0.05138367,
-0.02064476,
0.025665753,
-0.023735605,
-0.014228322,
0.046610467,
0.012082987,
-0.014515235,
0.020931674,
-0.0035472992,
0.0294478,
-0.013132832,
-0.0144891525,
0.006651186,
0.029265217,
-0.02386602,
0.027934982,
0.011189642,
-0.01854507,
-0.0012112331,
0.007818404,
0.015076022,
0.02047522,
-0.013837075,
0.0020540426,
0.0020328502,
-0.01184824,
0.024322474,
-0.014906482,
0.02226191,
-0.0017508268,
0.003782047,
0.02377473,
-0.010257172,
-0.018049493,
0.018675487,
0.032395188,
-0.017658247,
-0.012285132,
0.010824479,
0.00026633273,
0.021440294,
0.043376166,
-0.016001971,
0.015323811,
-0.00073317916,
0.047366876,
-0.00380813,
-0.0065859784,
0.020188306,
-0.006788122,
0.0077792793,
-0.0060643167,
-0.017110502,
-0.0058263084,
0.013758826,
0.008072714,
-0.023148736,
0.016993128,
0.002402904,
0.026356954,
0.016288884,
0.019757934,
-0.010478878,
-0.055869963,
0.00010239647,
0.009742031,
-0.0036711937,
0.011613492,
0.012924167,
-0.01581939,
-0.022157578,
-0.010061549,
0.03763789,
0.0063773138,
0.004535196,
0.001972533,
-0.046506137,
-0.00022354016,
0.024596347,
-0.047445126,
0.025248423,
-0.012559004,
0.003945066,
-0.009409472,
0.006184951,
-0.016367134,
-0.0024501795,
0.0052687824,
-0.01971881,
-0.04679305,
0.0038896396,
-0.010459316,
-0.0116852205,
0.02412685,
0.02411381,
0.003932025,
0.008770436,
-0.0075836563,
0.006116483,
-0.0022072808,
0.0019138461,
-0.026239581,
0.0021681562,
-0.03450792,
0.0152455615,
-0.0038276922,
0.0020295898,
-0.004179814,
-0.0025186476,
-0.02284878,
-0.032551687,
-0.0072902213,
0.012682899,
-0.01506298,
-0.016654048,
0.0021192504,
-0.009194287,
-0.026696034,
0.011267891,
-0.012122112,
-0.0041146064,
0.008939977,
-0.0012805163,
-0.008196608,
0.019679686,
-0.007590177,
-0.011359182,
-0.02107513,
0.023500858,
-0.028300144,
-0.033229847,
0.023344358,
-0.006103441,
0.0051383674,
-0.0031674644,
-0.028326226,
-0.032708187,
0.005288345,
0.01100706,
-0.025013676,
-0.0045938827,
-0.020162223,
0.008072714,
0.025496213,
-0.0024355077,
-0.0103941085,
-0.013132832,
-0.0018845027,
-0.010218048,
-0.012630733,
0.0016611663,
-0.02014918,
0.01015284,
-0.007909695,
0.032186523,
0.01760608,
0.03328201,
0.009357306,
0.014058781,
0.029395634,
-0.019340605,
0.012539442,
-0.0059175994,
0.021362044,
0.014528276,
-0.0113722235,
0.008424835,
0.0010139798,
0.0039907116,
0.005007952,
0.019614479,
-0.012252528,
-0.006334929,
-0.011378745,
0.03362109,
-0.017866911,
-0.023839938,
-0.022900946,
0.006592499,
0.011483077,
0.01370666,
0.008014027,
-0.0061784303,
0.004848193,
-0.0045254147,
-0.0032603852,
-0.005382896,
-0.01828424,
0.0060382336,
-0.012069946,
0.00061050715,
0.007218493,
-0.0015160792,
-0.016028054,
0.004003753,
0.01997964,
0.00028874786,
0.014032698,
-0.013497995,
0.007753196,
-0.00061988074,
0.029865129,
0.007851007,
0.013002416,
0.031873528,
0.012037342,
0.0013742524,
-0.021101214,
0.031038867,
-0.0016383436,
0.004959046,
0.019171065,
0.006566416,
-0.003250604,
-0.004068961,
-0.0067555183,
0.022183662,
-0.013576244,
-0.005898037,
0.02648737,
-0.024557222,
-0.001320456,
-0.006677269,
-0.012891564,
0.018727653,
-0.017619122,
0.002572444,
0.012369902,
0.030830203,
0.0021257713,
0.006801164,
0.0034820915,
-0.001006644,
-0.030908452,
0.0037266205,
-0.002860988,
0.008750874,
0.0010082742,
-0.026057,
0.0050633783,
-0.014932564,
-0.0106614595,
0.02801323,
-0.03182136,
-0.0078053623,
0.016406259,
0.025339715,
0.006413178,
0.0067816013,
0.009689865,
-0.0055622174,
-0.025861375,
0.008398753,
0.021857623,
-0.0051742312,
-0.017162668,
-0.038811628,
-0.0021877184,
-0.0053013866,
-0.0127089815,
0.024909344,
0.008868248,
-0.007225014,
-0.0068924543,
-0.0052524805,
0.0035309973,
0.0067816013,
0.006801164,
0.027856732,
-0.007133723,
0.01278071,
-0.018727653,
-0.014515235,
-0.013993573,
0.041602515,
0.026291747,
-0.012878522,
-0.0071793683,
0.006735956,
-0.02749157,
0.00006164166,
-0.015258603,
-0.014293529,
0.0100354655,
0.011515681,
-0.0044308635,
0.03325593,
0.007890132,
0.036125068,
0.0022072808,
-0.0076619056,
-0.037272725,
-0.0044471654,
-0.01209603,
0.029134803,
0.02437464,
0.0031495322,
0.0015185245,
0.014150072,
-0.0012813314,
0.004476509,
-0.027439402,
0.016732298,
-0.0075836563,
-0.018166866,
-0.012937209,
-0.0051546693,
-0.013348017,
0.0014965169,
0.03842038,
-0.007159806,
-0.0009984929,
-0.01658884,
-0.004434124,
0.016914878,
0.0021877184,
0.023148736,
0.037011895,
0.03088237,
-0.004466728,
0.015584641,
0.014997772,
-0.013654494,
-0.008959538,
-0.014463069,
0.019236272,
-0.00030158565,
0.0020833863,
-0.010674502,
-0.030178126,
-0.0035538198,
0.026865575,
0.00018991744,
0.013380622,
0.012617691,
0.0144891525,
0.007896653,
-0.010133278,
-0.0017214834,
-0.0015992189,
-0.02047522,
-0.0067489976,
0.0013253466,
-0.01904065,
0.02861314,
-0.043558747,
-0.0066153216,
-0.01668013,
0.0052753035,
0.016197594,
-0.01404574,
0.0042417613,
-0.008535689,
0.0030354187,
0.000029063278,
-0.031038867,
0.009357306,
-0.02115338,
-0.01006807,
-0.0225097,
-0.016197594,
-0.013497995,
-0.026539536,
-0.008366149,
0.02073605,
-0.0084378775,
-0.032890767,
-0.007440199,
0.022405367,
0.01954927,
0.006618582,
-0.012024301,
0.012330777,
0.036411982,
-0.010055028,
-0.022222785,
-0.009044309,
-0.023579106,
0.004587362,
-0.0040624402,
-0.014293529,
-0.005516572,
-0.027022073,
0.004098304,
0.013889241,
0.002919675,
-0.017162668,
0.0006382204,
-0.0062077735,
0.023122652,
0.0066837897,
-0.0034560084,
-0.010048508,
0.003733141,
-0.010426712,
-0.04188943,
-0.026669951,
-0.014684775,
-0.0032880986,
-0.0164193,
0.004411301,
0.007251097,
-0.0043884786,
-0.0077988417,
0.019301482,
-0.01692792,
0.007674947,
-0.00820965,
0.0011949312,
0.010850562,
0.007837966,
0.007075036,
0.0056502474,
-0.013758826,
0.0052916054,
-0.006491427,
0.035499074,
-0.024570264,
-0.030830203,
-0.0068924543,
-0.011789553,
-0.0034397065,
-0.033125516,
-0.008640021,
-0.009539887,
0.027882814,
-0.0066316235,
-0.0010938592,
-0.0008411794,
-0.024935426,
0.006801164,
0.021857623,
0.015962847,
-0.023839938,
0.0070815566,
0.031612694,
0.0033207024,
-0.024609389,
0.01954927,
-0.03883771,
-0.026513454,
0.009350785,
0.015519434,
0.0067229145,
-0.0042287195,
0.015141229,
-0.017762579,
-0.022496657,
-0.004600404,
-0.025652712,
-0.003037049,
-0.014593485,
0.049610022,
0.032395188,
0.029969461,
-0.011346141,
0.025952667,
0.021257712,
-0.0004450426,
0.0048775366,
-0.014697817,
0.023592148,
-0.010081111,
0.02749157,
0.024139892,
-0.00014875508,
0.007922736,
-0.0029799922,
0.004095044,
0.021179462,
-0.015389019,
-0.015362935,
0.013380622,
-0.045384564,
-0.03216044,
0.016288884,
0.0012617691,
-0.0027533954,
-0.049010113,
0.009200808,
0.020540427,
0.0013440938,
-0.016367134,
0.025770085,
0.040741775,
-0.0025267985,
0.0045123734,
-0.023709523,
-0.018766778,
-0.0065207705,
0.00169214,
-0.0067750807,
-0.031430114,
-0.0018633102,
-0.006951141,
0.006214294,
0.030986702,
-0.025704877,
0.00070546585,
0.0014557621,
-0.026565619,
-0.019327564,
-0.015284686,
-0.0314562,
-0.014410903,
-0.015754182,
-0.014645651,
-0.0008326209,
-0.019744894,
0.0059632445,
-0.025665753,
0.0065338123,
-0.016458426,
-0.005340511,
0.02952605,
-0.003707058,
0.008698707,
-0.016067179,
0.018597238,
0.028587058,
-0.007498886,
-0.021714166,
0.0032440834,
-0.0028723995,
0.0008428096,
0.04011578,
0.02895222,
0.0036842353,
-0.029839046,
0.0044993316,
0.0035864238,
-0.014006615,
-0.024531139,
0.01759304,
0.010120236,
-0.006912017,
-0.009878967,
-0.023513898,
-0.036255483,
0.01523252,
-0.0046916944,
0.0014606526,
0.010863604,
-0.002445289,
-0.010426712,
0.030099876,
0.008235733,
0.007837966,
0.0023246547,
0.0025691837,
-0.029395634,
-0.018310323,
-0.011919969,
0.0053698546,
-0.00685333,
0.019301482,
-0.02098384,
0.006034973,
0.020253513,
0.00592412,
-0.0014019656,
-0.0008191718,
0.0056143836,
0.037116226,
-0.022927029,
0.0044145617,
0.022131495,
-0.0077075507,
0.004179814,
-0.009468159,
-0.008470481,
-0.0035538198,
-0.020788217,
-0.017579997,
0.035264328,
0.014528276,
0.0015299357,
0.0022398846,
-0.020762132,
-0.013432788,
-0.026422162,
-0.030647622,
-0.00947468,
-0.03046504,
-0.004196116,
0.0045743207,
0.028326226,
0.013615369,
-0.011046185,
0.0047862455,
0.003961368,
0.03479483,
-0.013680576,
0.021909788,
0.02064476,
0.016262801,
-0.03072587,
0.011998218,
-0.00049639365,
-0.04230676,
-0.008776957,
-0.015949804,
-0.024883261,
-0.012135154,
-0.011528722,
0.020031808,
-0.00931166,
-0.010974457,
0.005777403,
0.007440199,
0.026200457,
0.008685666,
-0.0034462272,
0.016706213,
-0.023905145,
-0.0012642144,
0.007994465,
-0.006269721,
-0.0014459809,
-0.012480754,
-0.009702907,
-0.010557127,
-0.020996882,
-0.007890132,
-0.009402951,
-0.0017410457,
-0.0018551592,
-0.004068961,
-0.025274506,
-0.023683438,
-0.009885488,
0.002107839,
0.021648958,
-0.016954003,
-0.011228767,
0.009944175,
0.01261117,
0.0181147,
-0.01227209,
-0.009963738,
-0.00032522343,
-0.026265664,
-0.015036897,
0.007016349,
-0.015623766,
0.024987593,
0.006735956,
0.0012748106,
-0.025118008,
0.01988835,
-0.058165275,
-0.044888984,
0.030412873,
0.013928366,
-0.0039026812,
0.0144891525,
-0.028717473,
-0.018088618,
-0.0058263084,
0.0062827626,
-0.0021632656,
-0.0138762,
0.010811438,
-0.017397415,
0.0048710154,
0.02412685,
-0.013889241,
-0.03030854,
0.03223869,
0.006413178,
-0.016041096,
0.015389019,
-0.00082039443,
0.044054326,
-0.015545517,
0.023918187,
-0.0047862455,
0.006240377,
0.024218142,
-0.033047266,
-0.0130285,
-0.0031707247,
-0.0073945536,
0.00956597,
0.016158469,
-0.0029816222,
0.020097015,
0.012161237,
0.012604649,
-0.027987147,
-0.00024493644,
0.011646097,
0.01278071,
0.008490044,
0.002023069,
0.010381066,
0.005516572,
-0.0019236273,
-0.0053209485,
0.001193301,
0.012793751,
-0.0023539981,
-0.00047560871,
0.004215678,
-0.009957217,
0.00005731146,
-0.0052590016,
-0.023487816,
0.009089954,
0.0056828517,
-0.018271198,
-0.013889241,
0.014123989,
-0.015258603,
-0.0242051,
-0.02403556,
-0.006184951,
-0.017945161,
-0.030438958,
-0.004916661,
-0.010426712,
-0.016093262,
-0.017958201,
0.007238055,
0.021505501,
0.002715901,
0.009755073,
-0.0075445315,
-0.005796965,
-0.0014272337,
0.18299891,
-0.017306125,
0.008411794,
0.019523187,
0.02530059,
0.00027142707,
0.025444048,
-0.004763423,
0.012982854,
0.012239486,
0.030934535,
-0.015454226,
0.002725682,
-0.0106614595,
0.033568926,
-0.004411301,
-0.014867357,
-0.015493351,
-0.013367579,
-0.022405367,
-0.00270775,
-0.016693173,
0.015780265,
-0.013863158,
0.0065598954,
0.012089509,
-0.011437432,
0.0046493094,
0.009676823,
-0.0025284288,
-0.02733507,
0.003097366,
-0.014841273,
0.0021730468,
0.029265217,
0.005744799,
-0.0037624845,
-0.013667535,
-0.004248282,
-0.008274858,
-0.0038472547,
0.002326285,
-0.00922689,
0.01447611,
0.0017491967,
0.034977414,
-0.002411055,
0.021088172,
0.013550161,
-0.006788122,
-0.046349637,
0.013380622,
-0.005422021,
0.017579997,
-0.007153285,
0.01701921,
0.022522742,
0.017110502,
0.005363334,
0.03789872,
0.00006031713,
-0.0075445315,
-0.022979196,
0.012872001,
-0.011561326,
0.009194287,
0.005350292,
-0.00998982,
0.011574368,
-0.008783478,
-0.0011305386,
-0.006334929,
-0.014006615,
0.005735018,
0.0073815123,
-0.023631273,
0.026513454,
-0.003775526,
0.007016349,
0.012167757,
0.019144982,
0.0013799581,
-0.035420824,
0.00077311887,
0.0069707036,
-0.026096124,
0.012428588,
0.028117562,
-0.010374546,
-0.0078575285,
0.008392232,
-0.013745785,
-0.0017997327,
-0.00947468,
-0.008411794,
0.0036842353,
0.013745785,
0.00795534,
-0.0038016092,
-0.01548031,
-0.040846106,
0.06865067,
0.021727208,
0.008744353,
-0.003971149,
0.021414211,
0.014176155,
-0.0056143836,
-0.014019657,
-0.0022887904,
0.015806347,
-0.028900055,
0.008027068,
-0.0054122396,
-0.00078004715,
0.035525158,
0.010361505,
-0.022822697,
0.06176474,
-0.013406704,
0.007851007,
-0.018049493,
-0.0062240753,
0.03562949,
-0.00013530599,
0.016627965,
-0.028378394,
0.012056905,
0.012839397,
-0.01598893,
-0.02031872,
-0.02098384,
0.008144442,
0.012239486,
0.012656815,
-0.015493351,
-0.0085682925,
-0.0035179558,
-0.033490676,
-0.0017508268,
-0.00804011,
-0.015349894,
0.009181245,
0.012337298,
0.0021306619,
-0.020879507,
0.007916216,
0.021453336,
-0.0037364014,
-0.036777146,
0.003147902,
-0.027230738,
-0.0008419945,
-0.0006691941,
0.023135694,
-0.0127546275,
-0.034403585,
-0.0174235,
0.015167313,
0.013263247,
-0.018036451,
0.023592148,
0.007890132,
-0.008679146,
-0.0069967867,
-0.006762039,
-0.16192378,
0.017188752,
0.049401358,
-0.022770531,
0.03706406,
-0.013087186,
0.015415101,
-0.022953112,
-0.010002862,
0.004215678,
0.0431675,
-0.006827247,
-0.041080855,
-0.01591068,
0.0045319353,
0.0043786974,
-0.013654494,
0.03216044,
0.013100228,
0.01921019,
0.028326226,
-0.02031872,
0.0017866911,
-0.017932119,
0.013302372,
-0.010309339,
0.009911572,
0.0011101612,
-0.0051122843,
-0.022835739,
0.0041569914,
0.0012854069,
0.02531363,
0.008424835,
0.018845027,
0.011287454,
-0.004137429,
0.0015617246,
-0.00837919,
-0.002887071,
0.018740695,
0.018492905,
0.0064686043,
0.00029669507,
-0.009318181,
0.0073228255,
-0.0035081746,
-0.01701921,
0.01589764,
-0.019588394,
0.02445289,
-0.021140339,
0.0083009405,
0.030438958,
0.036438067,
0.01506298,
0.04173293,
-0.009546408,
0.001700291,
-0.0132893305,
0.0016334531,
-0.010798396,
0.00804011,
-0.017188752,
-0.0036907562,
-0.037429225,
-0.0062762415,
0.010420191,
-0.029056553,
-0.0030826943,
-0.033542845,
0.0010139798,
0.0060806186,
-0.02530059,
0.034847,
0.03367326,
0.004381958,
0.0055459156,
-0.007101119,
-0.005457885,
-0.038133465,
0.017840829,
-0.028169729,
-0.007753196,
-0.0035603407,
0.02031872,
0.013497995,
-0.0016905097,
-0.0033875403,
0.0015185245,
-0.00023882322,
-0.017540872,
-0.0031250792,
-0.006413178,
0.03891596,
0.020618677,
0.0008240624,
-0.020840382,
-0.014658692,
-0.007564094,
0.025248423,
-0.013941407,
-0.015806347,
0.013602328,
0.023266109,
0.0046590907,
-0.016367134,
0.01692792,
0.033960175,
-0.0038668169,
-0.027126405,
0.0027615463,
0.015519434,
0.025861375,
0.0073489086,
0.03012596,
0.0083009405,
-0.0025528816,
0.012676378,
-0.023487816,
0.065155536,
-0.0062240753,
-0.013321934,
0.022574907,
0.017371332,
-0.0054807076,
-0.14721292,
-0.003190287,
-0.0039124624,
-0.0032978796,
-0.03137795,
0.019027608,
0.0056306855,
0.008033589,
-0.030699788,
0.02403556,
-0.016875755,
-0.015845472,
0.009520325,
-0.019562311,
0.02869139,
-0.011398307,
0.014189197,
0.009298619,
-0.028326226,
0.033881925,
0.013087186,
0.0007698585,
-0.028821805,
-0.008053152,
0.016041096,
0.03518608,
-0.056130793,
0.033073347,
0.014867357,
0.024648512,
0.01345887,
-0.009096475,
0.040767856,
0.0013106748,
-0.011659138,
-0.007153285,
-0.015428144,
-0.037533555,
0.021544626,
-0.0048677553,
0.008085756,
0.02783065,
0.0017410457,
-0.009852884,
-0.010191964,
-0.013784909,
-0.024909344,
-0.01734525,
0.02090559,
-0.03419492,
-0.026422162,
-0.015780265,
-0.03510783,
-0.006501208,
0.013061103,
0.00019460425,
0.0021339222,
0.021009922,
-0.0070098285,
-0.0059762863,
-0.0001972533,
-0.011267891,
-0.0130285,
0.009181245,
0.016001971,
-0.015806347,
-0.011189642,
-0.019484062,
0.02835231,
-0.014371778,
-0.01032238,
0.011535243,
-0.019901391,
-0.028378394,
-0.0075966977,
0.0053046467,
-0.0021290316,
-0.0181147,
-0.0004205897,
-0.028743556,
-0.0015649849,
-0.018675487,
0.036333732,
-0.026969908,
0.020449137,
-0.0024941948,
0.00854221,
0.0006777526,
0.013615369,
-0.009213849,
0.006321887,
0.04037661,
-0.008920414,
-0.02377473,
-0.004857974,
0.0037168392,
0.0052492204,
0.016445383,
0.02767415,
0.020944715,
0.0012454672,
-0.003250604,
-0.05112284,
0.01218732,
-0.00014600412,
0.005627425,
0.008861727,
-0.025104966,
0.009435555,
-0.01666709,
0.01700617,
0.0006516695,
0.0048873173,
0.0016774682,
-0.0106614595,
0.030595455,
-0.016693173,
-0.022822697,
0.037611805,
0.0010327271,
0.011352661,
0.03343851,
-0.010361505,
-0.0312997,
0.0056861117,
0.004763423,
-0.019471021,
0.012304694,
-0.014032698,
0.04204593,
-0.011020103,
0.0061914716,
-0.0040917834,
-0.019953558,
-0.0152455615,
-0.005408979,
-0.020175263,
-0.008574814,
0.026096124,
0.021805456,
0.013967491,
0.033151597,
-0.01285896,
-0.022835739,
0.03529041,
0.011900406,
-0.0035831635,
0.022366242,
-0.01717571,
0.004258063,
-0.0051970542,
-0.0013310523,
0.04027228,
0.011893885,
-0.002608308,
-0.027726317,
0.007075036,
0.0014924414,
-0.00084770017,
-0.007427158,
-0.008242254,
-0.007505407,
0.03409059,
0.011691742,
0.005858912,
0.016015012,
-0.007974902,
-0.014541319,
-0.029056553,
0.009292098,
0.0021681562,
-0.019679686,
-0.026083082,
0.005069899,
0.01564985,
-0.010602773,
0.018766778,
-0.002606678,
-0.0039287643,
0.009494242,
-0.003987451,
0.011143997,
0.020605635,
0.008470481,
-0.019158024,
0.018818945,
0.033125516,
0.015636807,
-0.0065892385,
0.03800305,
-0.0067489976,
-0.017032253,
-0.0048710154,
0.027361153,
0.022953112,
-0.0116787,
0.0053959377,
0.03197786,
-0.017449582,
0.020762132,
0.016067179,
0.035316493,
-0.005314428,
0.010720147,
0.026696034,
-0.013380622,
-0.018088618,
0.011835199,
-0.03461225,
-0.024805011,
-0.016367134,
-0.011548284,
-0.00090231164,
0.009755073,
-0.0052622617,
-0.008105318,
-0.04022011,
0.0026963386,
0.04113302,
-0.0174235,
-0.003081064,
0.058686934,
0.007564094,
0.018401615,
0.0015755811,
-0.001125648,
0.0019024349,
0.0022985716,
0.026513454,
-0.028326226,
0.027022073,
0.0010865234,
0.026409121,
0.015049938,
-0.008640021,
-0.01692792,
-0.006820726,
-0.0397767,
0.008424835,
0.022470575,
-0.019927476,
0.0837267,
0.017840829,
-0.01024413,
0.012982854,
-0.026552578,
0.021779373,
0.029421717,
0.03755964,
-0.009448596,
-0.024909344,
0.02395731,
-0.028847888,
0.034377504,
-0.030621538,
-0.012735065,
0.026604744,
-0.021792416,
0.010368025,
-0.007538011,
0.004082002,
0.0077466755,
-0.012917646,
0.0014174525,
0.023174819,
-0.021662,
-0.0060871392,
0.010544086,
-0.017997326,
-0.0017671288,
-0.014371778,
0.027569817,
0.0070815566,
-0.054878805,
-0.010700584,
-0.0029881431,
-0.0055100513,
-0.00160737,
-0.044732485,
0.012363381,
0.010472357,
-0.0025251685,
0.014176155,
-0.008405273,
-0.012800273,
0.0033190723,
-0.019249314,
-0.022183662,
-0.0033239627,
0.007453241
] |
Bullying is still prevalent in schools and is clearly stressful for victims. 1 2 It may also have undesirable consequences for bullies, with antisocial behaviour persisting into adulthood. Victims are generally reported to be weaker than the bullies. 2 3 This would suggest that very short pupils are more likely to be victims and less likely to be the aggressors. The Wessex growth study allowed us to examine the prevalence of bullying, as experienced or perpetrated by pupils of different heights. Ninety two short normal adolescents who had been below the third centile for height at school entry4 and 117 controls matched for age and | [
-0.01507379,
0.0019746535,
0.026832925,
-0.04140689,
-0.032146897,
0.03251519,
-0.014666035,
-0.011239576,
-0.0045576515,
-0.036408596,
0.008076184,
0.011055429,
0.012739063,
-0.0027770104,
0.009713782,
0.014587115,
0.036855813,
-0.022242391,
-0.0042090863,
-0.011607871,
0.0025468261,
0.017520322,
-0.012752216,
0.020795517,
-0.044537395,
0.004886486,
0.03114724,
-0.01700734,
0.0023182859,
-0.020098388,
0.0060209665,
-0.0025501144,
-0.010766054,
0.0023429485,
-0.04661563,
0.0034823613,
0.019401258,
-0.01137111,
0.0073395944,
0.0020831688,
0.023886565,
-0.009075843,
-0.012364191,
-0.008727278,
-0.012594376,
0.008904848,
-0.0012183333,
-0.017388787,
-0.017178334,
-0.008904848,
0.03572462,
0.015547313,
-0.015323705,
-0.012719333,
0.004070976,
-0.027253835,
0.020282535,
0.024517927,
0.011765712,
-0.024189094,
-0.021860942,
-0.0037355642,
-0.023044748,
0.017757082,
-0.027595822,
-0.0017641991,
-0.019440718,
0.017651856,
0.0018414753,
-0.008733855,
0.024031252,
0.03703996,
0.01135138,
-0.0047089155,
0.007063373,
-0.0006593139,
0.01059506,
0.0022179913,
0.0017050088,
-0.009509904,
0.01352169,
-0.037802856,
-0.014652882,
0.022242391,
0.0024629731,
0.003554705,
-0.0032587536,
-0.0033524716,
-0.011364534,
-0.011075159,
-0.024899377,
0.0030318575,
0.009483598,
0.015862994,
-0.0011821614,
0.017836003,
-0.006395838,
0.027253835,
0.0015035975,
-0.019190803,
0.011160656,
-0.024004946,
-0.0052120327,
-0.011995896,
-0.010641096,
0.010003157,
-0.021689948,
-0.00098075,
0.009661169,
-0.015363165,
-0.021900402,
0.015849842,
-0.0034527662,
-0.019427564,
0.018954042,
0.0059453347,
0.01627075,
-0.021098046,
-0.005613211,
-0.02011154,
0.028911162,
-0.009779549,
0.022031937,
-0.005442217,
0.018020151,
0.0012594375,
-0.02293952,
-0.0016713033,
-0.012522032,
-0.0069449926,
-0.0066424645,
0.036671665,
0.009135033,
-0.014837029,
-0.00213085,
-0.018651513,
0.00019575951,
-0.027569516,
-0.016941573,
-0.02770105,
-0.0014912662,
0.014271433,
-0.036724277,
-0.032015365,
0.0018496962,
0.024386395,
0.025938494,
0.028490253,
-0.03219951,
-0.0030959803,
-0.011713098,
-0.005100229,
0.0017461132,
0.00092155975,
0.00026265686,
0.023281509,
-0.0113316495,
0.014166206,
-0.023071054,
-0.015047484,
0.0011468116,
0.018677821,
0.022413384,
0.002640544,
-0.010904164,
0.00043858352,
0.021098046,
-0.011443454,
0.026135795,
-0.013942598,
0.0028312684,
0.035382632,
-0.03122616,
0.006507642,
0.017928077,
0.009555941,
0.008128798,
0.014521348,
0.0020963224,
-0.018533133,
-0.039302345,
0.0024120037,
0.0055967695,
0.036724277,
-0.004130166,
0.009470444,
0.026898693,
0.008720701,
0.0034659195,
-0.0060209665,
0.016257595,
0.03638229,
-0.014074133,
-0.01933549,
-0.65114564,
-0.023044748,
0.013837371,
0.0033705574,
-0.017678162,
0.021058585,
0.01844106,
0.007957804,
0.0056263646,
0.005146266,
0.007898614,
0.007984111,
0.016033988,
-0.013850525,
-0.00505748,
-0.016297055,
-0.014666035,
-0.008036724,
0.03072633,
-0.023886565,
0.01200905,
0.020703444,
-0.012568069,
0.008576013,
0.019611713,
0.011443454,
0.0070370664,
-0.032962408,
0.014245126,
0.027674742,
-0.009233683,
0.027411675,
-0.015941914,
0.034698654,
0.04653671,
-0.0075303186,
-0.012850867,
0.03777655,
0.016073449,
0.005409334,
-0.017033646,
0.004544498,
0.01770447,
-0.013416463,
0.02626733,
0.014639729,
0.024780996,
-0.01356115,
0.033304397,
0.0066983663,
0.020387761,
0.009779549,
0.008773315,
-0.014074133,
0.018690974,
-0.017691316,
0.022110857,
-0.0028312684,
-0.004948965,
-0.004623418,
-0.008168258,
0.024965143,
0.0075500486,
0.02646463,
0.012160313,
0.014823876,
-0.03427775,
0.031778604,
-0.010976508,
-0.018467367,
0.01987478,
0.038065925,
-0.026135795,
-0.00030376122,
0.02084813,
0.046273645,
0.019927394,
-0.02363665,
-0.037145186,
0.010937048,
-0.017796542,
-0.006478047,
-0.02405756,
0.015310552,
0.018296372,
0.008082761,
0.0018266777,
0.022216083,
0.008589167,
-0.0076618525,
-0.0075303186,
0.0042682765,
-0.012482571,
-0.03909189,
-0.031252466,
0.04206456,
-0.007372478,
-0.003761871,
0.028963776,
0.0019927393,
-0.02336043,
0.017809696,
0.008372135,
-0.017217794,
-0.006609581,
0.034698654,
-0.0010867992,
-0.0005458659,
0.018625207,
-0.022439692,
0.025267672,
0.019230263,
-0.0050969403,
0.023084208,
0.012120853,
-0.0356457,
0.02925315,
-0.025780654,
-0.01061479,
-0.008161682,
0.01071344,
0.0065503907,
0.019361798,
-0.014455581,
0.012745639,
0.004646437,
0.0035316865,
-0.000063300715,
0.0019384816,
-0.012403651,
-0.014481888,
-0.021926709,
0.019427564,
0.0004665345,
0.051403467,
0.014350354,
0.020335149,
-0.0050772103,
0.020506142,
-0.014442428,
0.00033911096,
-0.008589167,
0.007372478,
0.012377345,
-0.023307815,
-0.032988716,
-0.009707205,
-0.005705285,
0.0023166416,
0.010989661,
0.017441401,
-0.020953357,
-0.0036928155,
0.010029464,
-0.0092797205,
-0.0052547813,
-0.022124011,
-0.006185384,
0.021098046,
-0.00003789308,
-0.009529634,
0.023912871,
-0.02638571,
0.0034856496,
0.001556211,
0.0064089918,
-0.016283903,
-0.0052482043,
0.0026898691,
-0.029279457,
0.011200116,
-0.0086812405,
0.011838055,
0.015179018,
-0.0044063875,
0.013837371,
-0.013304659,
0.009805856,
-0.022373924,
0.010022887,
0.0010572041,
-0.011936706,
-0.008937731,
0.0021834637,
0.0019779417,
0.019506484,
-0.00018198956,
-0.012574646,
-0.015507853,
0.0061919605,
0.018151686,
0.015100097,
-0.04580012,
0.012258964,
-0.012752216,
-0.006385973,
0.007819694,
0.024504775,
0.009595402,
0.04138058,
0.0113316495,
-0.007260674,
0.008280062,
0.012035356,
0.021597875,
-0.03251519,
-0.005139689,
-0.032567807,
0.008194565,
0.0121077,
0.01063452,
0.0018727146,
-0.007964381,
-0.013015284,
-0.0063202064,
0.026780313,
0.008227449,
0.012962671,
-0.007306711,
-0.032331046,
-0.008654933,
-0.023952331,
0.007477705,
0.0014378305,
0.015126404,
0.02634625,
0.013876831,
-0.007984111,
-0.005761187,
-0.016717965,
-0.009674322,
-0.007563202,
0.024162786,
0.012633836,
-0.015021177,
0.017836003,
0.026793465,
-0.0030219925,
0.0063037644,
0.020887591,
0.0029907532,
0.015047484,
-0.022018783,
0.0017280272,
0.031199852,
0.0069186855,
0.02670139,
0.024110172,
-0.0046891854,
0.012410228,
0.014455581,
0.014495041,
0.0004299516,
-0.010147844,
0.0048601795,
-0.0026471207,
0.017349327,
0.03325178,
0.01216689,
0.011752558,
0.008076184,
-0.013863678,
0.010818668,
-0.0006806882,
0.018454213,
-0.00035843,
-0.016165523,
0.003112422,
-0.00016750026,
-0.023689264,
-0.03130508,
0.012357615,
0.028016731,
-0.025622813,
0.025372898,
0.0010210322,
-0.031252466,
-0.00051421556,
0.030621104,
0.037355643,
-0.013797911,
-0.011693368,
0.0074382448,
0.026490938,
-0.0042945836,
-0.013784758,
0.0025057218,
-0.006826612,
-0.012535186,
-0.0019121747,
0.002877305,
0.014534501,
0.007799963,
-0.00601439,
-0.0019187515,
0.008766738,
0.009029806,
0.01196959,
0.000367884,
-0.0050607687,
0.03114724,
-0.012160313,
-0.027569516,
0.012745639,
0.006820035,
0.0039723255,
-0.02026938,
-0.021795176,
-0.02843764,
0.014784416,
-0.010937048,
-0.0024563966,
-0.0045971116,
0.051903296,
-0.011463184,
0.013232315,
0.03056849,
-0.0020782363,
0.043090522,
-0.031410307,
-0.018559441,
-0.018467367,
-0.027885197,
-0.031199852,
0.09444138,
0.032067977,
0.002517231,
0.039354958,
0.022465998,
-0.0016869229,
0.007938074,
0.0015340147,
0.006175519,
-0.011134349,
0.01194986,
-0.026872385,
0.03451451,
-0.003347539,
0.019203957,
0.021689948,
0.0037026806,
-0.008352405,
0.0029200537,
-0.0012849222,
0.01206824,
-0.01352169,
0.01511325,
0.035856154,
0.010891011,
0.0011155723,
-0.004725357,
0.0072277905,
-0.0011648976,
0.0022936233,
-0.01732302,
0.019677479,
0.0113448035,
0.01557362,
-0.024202246,
-0.007254097,
-0.017757082,
0.028227186,
-0.0026175256,
0.0020206904,
0.031673376,
-0.008865388,
0.018954042,
0.0038144845,
-0.0026553415,
-0.004564228,
0.016323363,
0.0038111962,
-0.0016934996,
-0.02084813,
0.00501802,
-0.019467024,
-0.006658906,
-0.0038670981,
-0.013837371,
-0.010022887,
-0.013383579,
0.014810722,
-0.007997264,
-0.00038720306,
-0.003919712,
-0.003847368,
0.010187305,
-0.01565254,
-0.018243758,
-0.015955068,
-0.01063452,
0.016099755,
-0.005531003,
-0.012923211,
-0.010128114,
-0.008700971,
-0.002846066,
0.011318496,
0.014547654,
0.0039723255,
0.02684608,
0.00424197,
-0.0125154555,
0.018348986,
-0.015757767,
0.0028838818,
-0.011482914,
-0.018348986,
0.023242049,
0.035750926,
0.0029069004,
-0.0043866574,
-0.029963434,
-0.005175861,
-0.022873754,
-0.010285955,
-0.013232315,
-0.027385369,
-0.019230263,
-0.019059269,
0.014639729,
0.010121537,
-0.0006239642,
-0.002744127,
-0.0030532319,
-0.023531424,
-0.0027868755,
0.00047845475,
0.009542788,
-0.0002677949,
-0.014429274,
0.0052350513,
0.005481677,
-0.03267303,
0.012587799,
-0.036434904,
0.00038679203,
0.018112225,
0.016599584,
-0.00068644277,
0.008556283,
0.028016731,
0.037934393,
0.009424407,
0.0043241787,
-0.040617682,
0.0067871516,
-0.009404677,
-0.03080525,
-0.0037585825,
0.009746666,
-0.021624181,
-0.032883488,
-0.0036632204,
0.0014830453,
0.0013317813,
-0.001376996,
-0.00605385,
-0.03425144,
0.016020834,
0.018270066,
0.01674427,
-0.009509904,
-0.025846422,
-0.015586773,
0.0058236658,
-0.02107174,
-0.03901297,
0.028306106,
-0.030016048,
-0.030016048,
0.014126746,
-0.0008557928,
0.011502644,
-0.022926368,
0.014205666,
-0.0023199301,
0.014837029,
0.00093389105,
-0.03277826,
-0.005340278,
0.008733855,
0.017388787,
0.007543472,
0.02007208,
0.0211112,
0.007675006,
0.0136926845,
0.004988425,
0.0014838674,
-0.014113593,
-0.0035382633,
-0.02134796,
0.013469077,
-0.0005244916,
0.018848814,
0.010818668,
-0.017441401,
0.007352748,
0.04664194,
0.00780654,
0.018309526,
-0.0044754427,
-0.036803197,
0.017559782,
-0.008418173,
-0.009904507,
0.02483361,
-0.04900955,
-0.007083103,
-0.0007287803,
-0.007326441,
0.0011624313,
-0.02076921,
-0.0072277905,
-0.022281852,
-0.0016902112,
-0.025846422,
-0.010877858,
-0.010831821,
-0.01851998,
-0.015784074,
0.01204851,
0.017033646,
0.009154763,
0.021966169,
0.0015323705,
-0.015100097,
-0.016283903,
-0.009779549,
-0.018085917,
-0.017599242,
-0.017928077,
-0.009628285,
0.013252045,
0.008003841,
-0.029595139,
-0.012541762,
0.0032686186,
-0.017770236,
-0.038223766,
0.017928077,
-0.020795517,
0.0064714705,
-0.009430984,
-0.0038703864,
0.019230263,
-0.007977534,
0.041433193,
0.007004183,
0.006155789,
-0.013219162,
0.009930813,
0.020782365,
0.0046793204,
0.01638913,
-0.0057184384,
-0.008871965,
0.0064155683,
0.002846066,
-0.0066720597,
-0.021966169,
-0.036040302,
0.020677136,
0.00062930776,
-0.015915608,
-0.016731119,
-0.0039756135,
-0.06382027,
0.005165996,
-0.0045313444,
-0.0047385106,
0.00786573,
-0.022794833,
-0.010299108,
0.012640413,
-0.01642859,
0.030384343,
0.013054744,
0.008878541,
-0.026990766,
-0.0002575188,
-0.014126746,
0.0095822485,
0.009799279,
0.0050837873,
-0.014810722,
0.008733855,
-0.0024662616,
-0.0009018296,
0.00041885342,
0.020282535,
-0.020624524,
0.036697973,
-0.016783731,
-0.027595822,
0.0064024148,
-0.007260674,
0.0034527662,
0.004912793,
0.0047878358,
-0.04816773,
-0.0061886725,
-0.0010333636,
0.021611027,
0.029437298,
-0.003620472,
-0.0022936233,
-0.022623839,
-0.014652882,
-0.016336516,
-0.019138189,
-0.015244785,
-0.011851209,
-0.027253835,
0.0033623367,
-0.010562176,
0.024031252,
-0.014863336,
0.0017115856,
0.005149554,
0.04490569,
-0.028832242,
-0.0077013127,
0.009970273,
0.014034673,
-0.03517218,
0.0340936,
-0.0005581972,
-0.017401941,
0.01999316,
-0.011226422,
-0.012706179,
-0.02933207,
-0.0066621946,
0.024123326,
-0.031568147,
-0.00597493,
0.012923211,
0.020821825,
-0.005922316,
-0.01991424,
-0.017638702,
0.0017165181,
0.01561308,
-0.0029726673,
0.007859154,
-0.010009734,
0.020585064,
-0.015994528,
0.03851314,
-0.0049423883,
-0.027595822,
0.0038539446,
-0.029937128,
0.009161339,
-0.00025813538,
0.0015011312,
-0.014337201,
-0.003893405,
-0.009246836,
0.022176623,
-0.00025710778,
0.0004965407,
0.015323705,
0.007221214,
-0.014679189,
0.009161339,
-0.019388104,
-0.0044458476,
0.03425144,
-0.015784074,
-0.028016731,
-0.003732276,
-0.010687133,
0.028200878,
0.03988109,
-0.007063373,
-0.018651513,
-0.0018431195,
-0.050824717,
0.0029660906,
0.003817773,
0.020545604,
0.0073001343,
0.017757082,
0.0067871516,
0.016678505,
-0.0038243495,
0.025517587,
-0.044642624,
-0.022334464,
-0.012988977,
0.018638361,
0.009181069,
-0.0021078314,
-0.0001324588,
0.0058697024,
0.005560598,
-0.017336175,
-0.00086236943,
0.03048957,
0.002045353,
0.012890327,
-0.015757767,
0.012344461,
0.038302686,
-0.03401468,
-0.0017576223,
-0.02126904,
-0.0037750243,
-0.00033315082,
-0.010489833,
-0.022834294,
-0.014784416,
0.006852919,
-0.017257255,
0.017401941,
-0.001999316,
-0.013837371,
0.005438929,
0.004774682,
0.044195406,
0.010792361,
0.006422145,
0.023044748,
-0.0104372185,
0.0033376738,
-0.008839081,
0.014587115,
0.0067049433,
-0.0074448213,
0.022913214,
-0.014850182,
-0.006478047,
0.0016639044,
-0.004080841,
-0.026280483,
0.005810512,
-0.02704338,
-0.0042288164,
-0.010983084,
0.02634625,
0.009772972,
-0.007280404,
-0.02274222,
0.009167916,
-0.014942257,
-0.0073198644,
-0.026030568,
-0.008885118,
-0.0023347277,
0.002648765,
-0.020874437,
-0.010292532,
0.0095690945,
0.012975824,
0.0030581644,
-0.012679873,
-0.017138874,
0.19109252,
-0.007405361,
0.01204851,
0.028621787,
-0.0026125931,
-0.012522032,
0.03940757,
-0.0095756715,
-0.0022295003,
0.021479493,
0.015744613,
0.0098650465,
-0.010213611,
0.015586773,
0.02851656,
-0.027964117,
-0.0244127,
-0.0027950965,
0.0056263646,
-0.007984111,
0.0034823613,
-0.014139899,
-0.006346513,
-0.0013457567,
0.029937128,
0.018848814,
-0.023123669,
-0.000273344,
0.028385026,
0.007760503,
0.0036566437,
-0.010568753,
0.014324047,
0.0032258702,
-0.029226843,
-0.014639729,
0.011397417,
-0.050009206,
0.0086812405,
0.020295689,
0.010871281,
-0.003781601,
0.0042551234,
-0.01360061,
-0.010463526,
0.017178334,
-0.004488596,
-0.013929445,
-0.019506484,
0.0047385106,
-0.021637335,
0.0010917318,
0.020834977,
0.018612053,
-0.018625207,
0.0101675745,
0.013416463,
0.0119235525,
-0.0037651593,
-0.009207376,
0.020256229,
0.013495383,
-0.0032768394,
0.01844106,
-0.00052778,
0.009838739,
-0.029858207,
-0.0029118329,
-0.037908085,
-0.015336858,
-0.0075105885,
-0.0036336253,
-0.014744956,
0.021084892,
-0.038328994,
-0.016981034,
0.022794833,
0.02037461,
-0.018914582,
0.0068594953,
-0.0065438137,
-0.012180043,
-0.026819773,
0.018546287,
-0.01581038,
-0.010391182,
-0.00042131968,
0.01491595,
-0.02363665,
-0.018809354,
0.002461329,
0.002140715,
-0.007543472,
-0.0042978716,
0.012094547,
-0.007589509,
0.01700734,
0.045273986,
-0.009759819,
0.012331308,
-0.03406729,
0.05645437,
0.01623129,
0.0012577934,
0.008266909,
-0.01196959,
-0.007596086,
0.0017609107,
-0.016375978,
0.0043767923,
-0.005531003,
-0.036592744,
0.013258622,
-0.004781259,
0.012245811,
-0.0031288639,
0.010292532,
-0.015941914,
0.007425091,
0.0011591429,
0.004876621,
-0.00083894,
0.035777234,
0.01720464,
0.011134349,
0.009970273,
-0.034382973,
-0.0014855115,
-0.023215743,
-0.006639176,
0.019743245,
-0.02343935,
-0.0034100176,
-0.009891353,
-0.028463947,
-0.0000667432,
0.0055671744,
-0.0011270816,
0.036171835,
-0.0058598374,
-0.008181412,
-0.03277826,
0.008240602,
0.016560124,
0.007392208,
-0.016178675,
0.005780917,
0.0086812405,
0.00782627,
-0.018138532,
-0.036855813,
-0.018506827,
-0.016297055,
-0.007122563,
0.0033738457,
-0.011903822,
-0.0062840343,
-0.020677136,
-0.015902454,
0.016599584,
-0.030121274,
0.028306106,
-0.0059453347,
0.010891011,
-0.0076618525,
-0.0071488703,
-0.16510141,
0.02119012,
0.013245469,
-0.011403994,
0.015376318,
-0.006346513,
0.014929104,
-0.0050509037,
-0.0172441,
-0.011759135,
0.015902454,
-0.0038605214,
-0.009490174,
-0.004534633,
-0.008648357,
-0.028753322,
0.0007752282,
0.028279798,
0.028700707,
-0.007688159,
0.008937731,
0.0007008293,
0.024162786,
0.012929787,
-0.01650751,
0.02065083,
-0.020782365,
0.022110857,
-0.008536553,
-0.024965143,
-0.0038901165,
-0.008635203,
0.01766501,
-0.013390156,
-0.018572593,
0.0040479572,
-0.009042959,
-0.005300818,
0.012041933,
0.015205325,
0.04877279,
0.029884513,
-0.0024909242,
0.021847788,
0.0083984425,
0.012962671,
0.0197564,
0.0014641372,
0.015231632,
-0.014389814,
0.0039854785,
-0.021611027,
0.03304133,
-0.005458659,
-0.0025961513,
0.0011591429,
0.0130942045,
-0.0008574369,
-0.008109068,
-0.009319181,
0.0008459277,
-0.009187646,
0.019809013,
0.007813117,
-0.033567462,
-0.029516218,
0.003771736,
-0.022926368,
-0.023307815,
-0.0062840343,
-0.021782022,
-0.026872385,
0.01057533,
-0.0026849366,
0.008365559,
0.007957804,
-0.014863336,
0.0070107593,
-0.03859206,
0.029621445,
0.011325073,
0.0072277905,
-0.0040676873,
0.0010950201,
-0.020953357,
0.040933363,
-0.0019812302,
0.022834294,
0.022071397,
-0.010397758,
0.010483256,
-0.016796885,
-0.015507853,
-0.005632941,
-0.0029266304,
0.01421882,
-0.00064328325,
0.009069266,
0.009036383,
0.0036171835,
0.004159761,
-0.013311235,
-0.0077736564,
-0.0031913423,
-0.001150922,
-0.027253835,
0.026214715,
-0.0017921501,
0.014034673,
-0.0014937324,
-0.006619446,
-0.0021374268,
0.0025221636,
-0.0015241497,
-0.002895391,
0.019427564,
-0.003696104,
-0.0032110724,
0.013429617,
-0.0077210427,
0.0678189,
0.0010103452,
-0.006287323,
0.002574777,
0.019098729,
-0.009450714,
-0.125536,
-0.007004183,
0.009437561,
0.020295689,
0.03285718,
0.012193197,
-0.0023445927,
0.012771946,
-0.018914582,
0.038407914,
-0.007990687,
-0.015231632,
-0.011219846,
-0.005836819,
0.015744613,
-0.027674742,
0.009384947,
-0.007392208,
-0.006336648,
0.0399074,
0.0012701247,
-0.011811748,
-0.012883751,
-0.0043570623,
-0.021532107,
0.01642859,
-0.015402625,
0.010187305,
0.0012051798,
0.01987478,
0.019138189,
0.003952595,
0.023136823,
0.012245811,
-0.01417936,
0.008891695,
-0.03959172,
-0.013745298,
0.012482571,
-0.009792702,
0.008707548,
0.010187305,
0.025609659,
-0.015928762,
-0.029410992,
-0.018940888,
-0.014192513,
0.007102833,
0.017349327,
-0.010904164,
-0.03451451,
-0.033620078,
-0.011976166,
-0.009608555,
0.02134796,
0.0211112,
0.0030663852,
-0.0012947873,
0.0046891854,
0.005771052,
-0.0012454621,
0.028569173,
-0.009654592,
0.00782627,
0.020400915,
-0.019361798,
-0.028674401,
-0.015389472,
0.018191146,
-0.028227186,
-0.018454213,
0.008299792,
-0.012094547,
0.0057874937,
-0.010397758,
-0.0012487504,
-0.037460867,
0.00074481097,
0.005241628,
-0.027069686,
-0.01137111,
-0.01708626,
0.01071344,
-0.0042978716,
0.013271775,
-0.009529634,
0.010805514,
-0.010851551,
0.009088996,
0.0032225817,
-0.0021785311,
0.020151,
0.02487307,
-0.0046497253,
-0.009457291,
0.008490517,
-0.004603688,
-0.012061663,
0.030331729,
0.010463526,
-0.015836688,
-0.023833951,
-0.026359404,
0.019098729,
0.00033294532,
0.003929577,
-0.030936785,
0.026201563,
0.016415438,
-0.02785889,
-0.007431668,
-0.0036467786,
0.006458317,
0.028832242,
-0.012318154,
-0.027359061,
-0.026333097,
-0.0043800804,
0.014508194,
-0.007707889,
0.01507379,
0.026925,
0.003761871,
0.01646805,
0.008871965,
0.026911845,
-0.0028033173,
0.0056789783,
-0.005721727,
0.018072765,
-0.0081024915,
-0.012535186,
0.006214979,
-0.05392892,
0.012449688,
-0.0076223924,
0.007589509,
-0.010364875,
0.012094547,
0.026175255,
0.021650488,
0.034961723,
-0.02991082,
-0.0016417081,
-0.009299451,
-0.0348565,
0.00088127743,
0.005179149,
-0.027359061,
0.01001631,
0.008207719,
-0.005741457,
0.037408255,
0.02003262,
0.007004183,
-0.038644675,
-0.0074513983,
0.0023182859,
-0.02049299,
0.008247179,
-0.02843764,
-0.009825586,
-0.007102833,
-0.022110857,
0.00265863,
0.007938074,
0.0032488885,
-0.024531081,
-0.02433378,
-0.008286639,
0.0041466076,
-0.0048338724,
-0.011838055,
0.0043241787,
-0.007477705,
-0.00005523398,
0.0017214506,
0.037566096,
-0.00045995778,
0.030121274,
-0.01937495,
0.015021177,
0.020598216,
0.0014583827,
0.009509904,
0.0110356985,
0.033725303,
-0.003988767,
-0.011200116,
-0.000034990087,
-0.0045872466,
-0.0038539446,
-0.015323705,
0.019743245,
-0.0151658645,
-0.009509904,
0.01670481,
0.038723595,
-0.016836345,
-0.008010417,
0.029384684,
0.008069607,
0.0048601795,
0.0017000763,
-0.020440375,
-0.022084551,
-0.014455581,
0.0061064637,
0.0054257754,
-0.0197564,
-0.0059617762,
0.018954042,
0.014455581,
-0.01979586,
-0.020440375,
-0.0014912662,
-0.034540813,
0.024859916,
-0.014731802,
-0.0062840343,
-0.010424065,
0.024110172,
0.002753992,
-0.00027848204,
-0.010476679,
-0.0047582407,
0.006438587,
-0.012416805,
-0.018112225,
-0.018427907,
-0.0027885197,
-0.014666035,
0.0125154555,
-0.020913897,
-0.036750585,
-0.011673638,
0.04032831,
-0.030173888,
0.0032160052,
0.019559098,
-0.011298766,
0.02917423,
0.007694736,
0.003413306,
0.0069055324,
-0.028095651,
0.022505458,
0.008411596,
0.007589509,
-0.01631021,
-0.028700707,
0.0017609107,
-0.021413727,
-0.012785099,
-0.022255544,
-0.0080893375,
0.0062412857,
-0.029095309,
-0.0010226765,
0.006912109,
-0.002846066,
0.026806619,
-0.022584379,
0.04693131,
0.014113593,
-0.015626233,
-0.013666377,
-0.002282114,
-0.0041992213,
0.0042781415,
-0.006395838,
-0.012679873,
0.014679189,
-0.06071607,
-0.027332755,
0.0010678913,
-0.02429432,
0.006385973,
-0.009891353,
-0.009680899,
-0.0021374268,
0.0066424645,
0.023491964,
-0.01344277,
-0.009542788,
-0.0139952125,
-0.016915265,
-0.0053534317,
-0.014074133,
-0.021124352
] |
Inflammasomes are multiprotein complexes that link pathogen recognition and cellular stress to the processing of the proinflammatory cytokine interleukin-1β (IL-1β). Whereas inflammasome-mediated activation is heavily studied in hematopoietic macrophages and dendritic cells, much less is known about microglia, resident tissue macrophages of the brain that originate from a distinct progenitor. To directly compare inflammasome-mediated activation in different types of macrophages, we isolated primary microglia and hematopoietic macrophages from adult, healthy rhesus macaques | [
-0.023035571,
-0.0013164592,
-0.021010755,
-0.025520572,
-0.017184641,
0.022194088,
-0.00054482673,
0.007888894,
-0.0067647267,
-0.015120381,
0.021891681,
-0.010742044,
0.007796857,
0.0035039838,
0.00529542,
0.015777787,
0.04386225,
0.022969829,
-0.00077533035,
0.00394116,
-0.04057521,
0.009821673,
-0.0047662067,
-0.012260656,
-0.00579505,
0.026690759,
0.00973621,
-0.038313728,
-0.02503409,
-0.03268632,
-0.0050784755,
-0.017500196,
-0.031844836,
-0.0032377336,
0.004785929,
-0.015133528,
0.022312421,
-0.016816493,
0.0033790763,
0.0014701283,
0.026046498,
0.012273804,
0.0077048196,
-0.017066307,
-0.0072577824,
-0.0019475707,
-0.011629544,
0.003065164,
-0.04178484,
-0.00077985006,
0.03465854,
-0.007790283,
-0.010991859,
0.016711308,
-0.027637426,
-0.018565197,
-0.0028613675,
0.008118987,
-0.001029665,
-0.03552632,
-0.020379642,
-0.008329357,
-0.020169273,
0.0242452,
0.017999826,
0.023232793,
0.013246768,
0.022772606,
0.0067713005,
-0.01797353,
0.04722818,
0.020734644,
-0.00994658,
-0.010137228,
0.0153307505,
-0.025467979,
-0.020866124,
-0.010603989,
0.007159171,
0.00157367,
0.020760939,
-0.01932779,
-0.0023929644,
0.033343725,
0.0103278775,
-0.0105711175,
-0.0029435435,
0.01903853,
0.022812052,
-0.018552048,
0.001512038,
0.024350386,
0.009525839,
0.029583352,
-0.007139449,
0.008335931,
0.0035960209,
0.01753964,
-0.012273804,
-0.005867365,
-0.020366495,
0.0016862511,
-0.024863165,
-0.016711308,
-0.026217423,
0.008145283,
0.015265009,
0.012418434,
0.011478341,
0.00855945,
-0.013292787,
0.013154731,
0.0013978134,
-0.05806226,
-0.0006828824,
0.004703753,
0.01397649,
-0.025560016,
0.0044046324,
-0.012346119,
0.014134268,
0.030898169,
0.0046577347,
-0.014134268,
0.020340199,
0.009269451,
-0.012865472,
-0.012983805,
-0.021523532,
-0.0117676,
-0.0041712527,
0.0154227875,
0.021865385,
-0.015449084,
-0.014068527,
0.019722234,
-0.01976168,
0.0024061126,
-0.021812791,
-0.01690853,
-0.0036025948,
0.0335278,
-0.0041646785,
-0.0050061606,
0.007474727,
0.02039279,
0.045466326,
0.0045229658,
-0.005144216,
0.018736124,
0.004920698,
-0.043125954,
0.0034185208,
-0.018670382,
0.015659455,
0.017907789,
-0.0068173194,
0.047044106,
-0.024771128,
-0.01547538,
0.0034941225,
-0.021562977,
0.009466672,
0.0171189,
0.00029028664,
0.013082416,
0.006557643,
0.015554269,
0.0041581043,
-0.0160539,
0.0034678264,
0.010354173,
-0.014449825,
0.023706127,
-0.01618538,
-0.001320568,
0.02097131,
0.027006313,
-0.017000567,
-0.027453352,
-0.009256302,
-0.010242414,
0.022167793,
-0.010078062,
-0.007139449,
-0.018709827,
0.03928669,
-0.0050949105,
0.0018818299,
-0.020405939,
0.013608342,
0.023009274,
-0.023929644,
-0.029004833,
-0.6357397,
-0.034790024,
0.026099091,
-0.011504637,
-0.010202969,
0.04023336,
0.004621577,
-0.0335278,
-0.0076653752,
0.024613349,
-0.023061866,
0.021615569,
0.0040003266,
-0.00323609,
-0.015317602,
-0.020721495,
-0.02147094,
-0.010262136,
0.0029040992,
-0.00984797,
-0.011346859,
-0.01476538,
-0.001067466,
0.010538247,
-0.038892247,
0.015054639,
0.031108538,
-0.020931866,
-0.016658714,
0.03694632,
-0.023285385,
0.014160565,
0.011629544,
0.0034185208,
0.0449404,
-0.014870565,
-0.026861684,
0.048832253,
0.009394358,
0.015988158,
-0.027216684,
-0.013687231,
-0.010689451,
-0.0006372747,
-0.00023358522,
0.017815752,
-0.006988245,
0.012293526,
0.012464453,
-0.0016369455,
0.005111346,
0.015527973,
-0.00026193593,
0.009585006,
0.004845096,
0.012096304,
0.023127608,
0.0011397809,
0.00447366,
0.012635378,
-0.016198529,
0.017776309,
-0.0072775045,
-0.023850756,
-0.001611471,
0.008697506,
-0.029662242,
-0.00855945,
0.014975751,
0.010137228,
0.012931212,
0.013095564,
-0.028715573,
-0.0010148734,
-0.009262877,
0.009492969,
-0.008243894,
0.016816493,
-0.004684031,
0.026782796,
-0.011708434,
-0.0052461145,
-0.026020203,
-0.009315469,
0.026020203,
-0.004509818,
0.005443337,
0.017302973,
-0.010840655,
-0.0015268297,
-0.00024406266,
-0.0045919935,
-0.020668902,
-0.05627411,
-0.017460752,
0.036472987,
0.015777787,
0.01726353,
0.026980018,
-0.01583038,
-0.0065905135,
-0.0018538901,
0.019577606,
0.00028576696,
0.028768167,
0.00038910325,
-0.042337064,
-0.008046672,
0.057536334,
-0.007803431,
0.0025951173,
0.015383343,
0.0029040992,
-0.016842788,
0.0030569464,
-0.018828161,
0.011051025,
0.014489269,
-0.0018341679,
-0.007067134,
0.026901128,
-0.0111825075,
0.003444817,
0.00157367,
0.028347425,
0.009893988,
0.005607689,
-0.019617049,
-0.016487788,
-0.0067515783,
0.00039793717,
0.009604729,
0.007836301,
-0.01583038,
0.011175933,
0.01834168,
0.0016714594,
0.008993339,
0.014318342,
-0.052908182,
-0.015199269,
-0.028294833,
0.0027841222,
-0.018275937,
-0.021576125,
0.004306021,
-0.015212418,
-0.003068451,
0.021010755,
0.013338805,
0.01362149,
0.009828247,
-0.011872785,
-0.017842049,
0.03294928,
0.0058607906,
-0.011386303,
-0.020366495,
-0.0031999326,
-0.022049459,
-0.024232052,
0.019709086,
0.0021152096,
0.02453446,
-0.022430755,
0.00050538225,
-0.0012309962,
-0.018578345,
-0.0019722234,
-0.038629286,
-0.007455005,
-0.0035894467,
-0.02811076,
0.040128175,
0.007954635,
0.0025803258,
-0.00223683,
0.0108472295,
0.0109063955,
-0.004200836,
-0.006320976,
-0.012352693,
0.014502416,
-0.009368062,
0.035131875,
0.015265009,
0.01789464,
-0.007461579,
0.014239454,
0.0356578,
-0.0058969483,
0.029083723,
-0.012773434,
0.023982238,
-0.009466672,
-0.018985938,
0.0031424095,
0.017026862,
-0.0012605796,
0.010893248,
0.0010115863,
-0.023193348,
0.015094084,
-0.021352606,
0.004269864,
-0.03237076,
0.007980931,
-0.007895468,
0.019866865,
0.0025195156,
-0.005371022,
0.00057605363,
-0.002268057,
-0.019511864,
0.011478341,
0.024928905,
0.009400932,
0.004611716,
0.005555096,
-0.020537421,
0.015896121,
-0.0045722714,
0.01412112,
-0.016303714,
-0.028925944,
0.023009274,
0.0034020855,
0.01868353,
-0.012043712,
-0.031266317,
0.000735475,
0.016448343,
0.011695285,
0.02532335,
0.016237974,
0.0032722475,
-0.009072228,
0.00034904247,
0.025047239,
0.0063472725,
0.009032784,
-0.0032065066,
-0.0029303953,
0.014673343,
0.0033001874,
-0.0063144024,
0.013818713,
0.0029583352,
0.009111673,
0.02680909,
-0.019248901,
-0.0075404677,
-0.0069290786,
-0.0017700706,
-0.019248901,
-0.0062388005,
0.011116766,
-0.004194262,
0.044467065,
0.02396909,
0.0011677206,
-0.022522792,
-0.010696026,
-0.01726353,
0.0010173386,
0.004102225,
0.010163525,
-0.017053159,
-0.007967783,
-0.01847316,
-0.047885586,
0.007310375,
0.008552876,
-0.03931299,
0.0062519484,
0.0077705607,
0.030267056,
0.009243154,
0.010584266,
-0.0030224326,
-0.020379642,
-0.03124002,
0.0067713005,
0.006935653,
-0.014436676,
-0.013818713,
-0.03507928,
0.013674083,
-0.0039904653,
0.006432736,
0.009387784,
0.017250381,
-0.011504637,
0.007967783,
-0.00820445,
-0.003776808,
0.0428104,
-0.0055090776,
0.019577606,
0.00023584506,
0.0099925995,
-0.0012129175,
-0.022220384,
-0.0070079677,
0.027979277,
0.0028301408,
0.0042238454,
-0.015409639,
-0.010465933,
-0.016671862,
0.005558383,
-0.012780008,
-0.0029616223,
-0.0051179198,
0.009433802,
-0.019301495,
-0.0034809744,
0.016198529,
0.03166076,
-0.005348013,
-0.0056701424,
-0.037892986,
0.03337002,
-0.00090886635,
0.0146601945,
0.0349741,
-0.0152387135,
0.009131394,
0.0007153419,
-0.012181767,
-0.012970656,
-0.014081676,
0.021523532,
-0.03195002,
-0.025757238,
0.0023206496,
0.0026970156,
0.0055287997,
0.01918316,
0.020655755,
0.00959158,
-0.019551309,
-0.009611302,
0.0022779182,
0.022049459,
0.011715008,
0.024902608,
0.017092604,
0.024613349,
0.0059758374,
-0.0023337977,
0.020103531,
-0.006136902,
-0.011215378,
-0.012773434,
0.017434455,
-0.00048114036,
-0.01126797,
-0.0008287447,
-0.011971396,
-0.004289586,
0.0059955595,
0.007461579,
0.010117507,
-0.011037878,
0.0115177855,
0.007731116,
-0.0024077562,
-0.0086186165,
-0.016987419,
0.006537921,
-0.005742457,
-0.010426488,
-0.003691345,
0.05406522,
-0.012129175,
-0.013555749,
-0.043047063,
0.010827507,
-0.023377422,
-0.004470373,
0.0008238142,
0.0031489835,
0.0007379403,
-0.0077508385,
-0.022115199,
-0.011662415,
-0.008677783,
-0.006110606,
-0.022785755,
-0.008612042,
0.0069488008,
-0.02903113,
0.0055846795,
0.01982742,
-0.015606862,
-0.025205016,
-0.0015202556,
0.013154731,
0.022088904,
0.01618538,
0.003937873,
0.011366582,
0.029372983,
-0.01255649,
-0.016422048,
-0.0030931039,
-0.05185633,
0.01576464,
0.0004556658,
0.006718708,
-0.018893901,
-0.016737603,
0.0010781488,
0.02118168,
-0.00702769,
-0.010209544,
0.019958902,
-0.013555749,
0.025717795,
0.020313902,
-0.001608184,
-0.020379642,
-0.035263356,
-0.0060317167,
-0.05235596,
-0.031397797,
-0.009499543,
-0.018091863,
-0.027768906,
-0.0022450478,
0.008086116,
0.008303061,
-0.0116098225,
0.010932692,
-0.00909195,
0.0021875245,
-0.010117507,
0.0068173194,
0.012023989,
-0.0060119946,
0.014673343,
0.002151367,
-0.0127997305,
-0.008500284,
-0.011307415,
0.023377422,
0.020668902,
-0.018065568,
0.0010584266,
0.0021546541,
0.002973127,
-0.006988245,
-0.014015935,
-0.022562237,
0.024429275,
0.011807045,
-0.022667423,
-0.0133782495,
-0.0105119515,
-0.0012186698,
0.010965562,
0.004253429,
-0.0078560235,
-0.005778615,
0.016356306,
-0.041337803,
0.0013969917,
0.012010841,
-0.03486891,
-0.009256302,
0.019091124,
0.002644423,
0.01947242,
-0.020524273,
-0.013516305,
-0.017184641,
-0.013029823,
-0.025928166,
-0.009565284,
0.017750012,
-0.017276678,
0.043835953,
0.009552136,
0.02724298,
0.004043058,
0.031161131,
0.017237233,
0.011668989,
-0.0036650486,
-0.0006968523,
0.011287692,
-0.0072972267,
0.024784274,
0.008105839,
0.002685511,
0.010899822,
-0.02018242,
0.0085265795,
0.015659455,
-0.005364448,
-0.035841875,
-0.008598895,
-0.02332483,
-0.030214464,
0.026506683,
-0.005288846,
-0.017644826,
-0.035631504,
0.0053414386,
0.020695198,
-0.0020165986,
0.005186948,
0.013476861,
0.030898169,
-0.034553356,
0.018709827,
-0.014042231,
0.024836868,
-0.012418434,
0.007645653,
0.010676303,
-0.010268711,
0.011938526,
0.0074155605,
-0.007934912,
-0.0048944014,
-0.015922418,
0.0034513911,
0.008533154,
-0.014318342,
-0.0038228265,
-0.025704646,
-0.024442423,
-0.021339457,
-0.02275946,
-0.021102792,
-0.03189743,
0.007606209,
0.0038228265,
-0.0019344225,
0.018696679,
-0.00834908,
-0.025191868,
0.030845575,
0.0053381515,
0.022365015,
-0.0167639,
0.00688306,
0.026717054,
0.003951021,
-0.01668501,
0.0009392714,
0.0007017829,
-0.00888158,
0.03189743,
0.026848536,
-0.037708912,
-0.017960383,
0.0037077803,
0.0031867845,
0.0058279205,
-0.021523532,
0.029162612,
0.02509983,
0.016132789,
-0.017079456,
-0.0074352827,
-0.0090459315,
0.015488529,
-0.031765945,
0.018815013,
0.014673343,
-0.00876982,
-0.017355567,
0.019498717,
0.007954635,
0.005910096,
0.012569638,
-0.027164092,
0.0006878129,
-0.026309462,
0.015488529,
-0.014949454,
0.020169273,
0.029504463,
-0.011313989,
0.01320075,
0.016527234,
0.03166076,
-0.015633158,
0.0019935893,
0.0002849452,
0.036762245,
0.007389264,
0.013325657,
0.011221952,
0.008552876,
0.0027956269,
-0.019880014,
-0.0008669566,
-0.019077975,
0.0071525974,
-0.0012474314,
0.0224702,
0.0011841558,
-0.0061960686,
0.0037307895,
-0.031792242,
-0.004956855,
-0.010341025,
-0.019630197,
0.0003928012,
-0.016645566,
-0.0056602815,
0.026125386,
0.0009836465,
0.019617049,
0.011774174,
0.011156211,
-0.016316863,
0.0066266707,
-0.022706866,
0.01840742,
0.0030618769,
0.006284819,
-0.010288432,
0.00070383726,
-0.018538902,
-0.024560757,
0.013950194,
-0.018525753,
-0.028952241,
0.015028343,
0.006051439,
0.009821673,
0.011175933,
-0.014528713,
0.0167639,
0.008362228,
0.011452044,
0.0060284296,
-0.013095564,
0.009453525,
-0.0385241,
-0.0027874091,
0.018144457,
-0.0009639242,
-0.020169273,
0.03523706,
-0.0068699117,
0.016211677,
0.004365188,
-0.019866865,
-0.011754452,
0.0053513,
-0.015567417,
0.016040752,
-0.021089643,
-0.016422048,
-0.010827507,
-0.002945187,
0.008303061,
-0.028925944,
-0.012438156,
0.015172972,
-0.0018604641,
0.015251862,
-0.009525839,
0.007974357,
-0.0038951414,
-0.03323854,
-0.029925205,
0.0026592147,
-0.051330402,
0.049489662,
-0.0005481138,
0.017644826,
-0.02345631,
-0.004588707,
-0.033343725,
-0.021549828,
0.0024307654,
0.01073547,
0.0019130568,
0.013213897,
-0.0013632994,
0.008447691,
-0.008907876,
0.00051811954,
-0.013792416,
-0.005387457,
-0.007211764,
-0.017592233,
0.015265009,
-0.009052506,
-0.001327142,
-0.024771128,
0.053539295,
-0.0008538084,
-0.002890951,
0.033501502,
-0.016869085,
0.010281858,
0.0024718535,
0.0031309049,
-0.00791519,
0.00018869659,
0.04099595,
-0.015501677,
0.008079542,
0.006988245,
-0.005203383,
-0.00026008696,
0.0044900957,
0.023311682,
0.0026493536,
0.0076719495,
0.008592321,
-0.020471679,
0.00738269,
-0.035184465,
0.03060891,
0.00197058,
-0.0054959296,
0.02153668,
0.012332971,
-0.034001134,
-0.009670469,
-0.0026789368,
-0.003947734,
-0.01834168,
-0.00226477,
0.007159171,
-0.015882973,
0.0050587533,
0.017066307,
-0.021628717,
0.008040098,
-0.028557796,
0.008612042,
-0.024126867,
0.0060185688,
-0.0021201402,
-0.017631678,
-0.0059265317,
-0.0054170405,
-0.013937046,
-0.021602422,
0.007849449,
0.00420741,
0.0054729204,
0.0014610889,
0.01294436,
0.0009770724,
-0.018893901,
-0.027900388,
-0.019170012,
-0.007119727,
0.015659455,
0.17650086,
-0.019156864,
-0.0010781488,
0.01584353,
-0.00056742516,
-0.0058081984,
0.004789216,
-0.011899082,
-0.0057325964,
-0.0052625495,
0.013319083,
0.0030733815,
0.008020376,
-0.0021365755,
0.027216684,
-0.008217598,
0.003697919,
-0.002138219,
-0.024705386,
-0.026664462,
-0.00060810224,
-0.0014898505,
-0.0007420491,
-0.000022457154,
0.04601855,
0.011642693,
-0.01376612,
0.01291149,
0.007823153,
0.01362149,
-0.03031965,
0.029872611,
-0.0120371375,
0.02332483,
0.00028412344,
0.006876486,
-0.023982238,
-0.0038096784,
0.009223432,
0.00955871,
0.0032919697,
-0.013430842,
0.021931125,
0.01547538,
0.0034974096,
0.008802691,
0.001347686,
-0.01584353,
-0.011715008,
0.011208803,
-0.0449404,
0.010216118,
-0.019459272,
0.012313249,
-0.0014462973,
-0.011287692,
0.0033133354,
0.023811312,
-0.004545975,
0.0063998653,
-0.013595194,
0.014686491,
-0.041548174,
0.031555574,
-0.003625604,
0.016790196,
-0.018249642,
-0.011175933,
0.007310375,
-0.023272237,
-0.0012227786,
0.0036453265,
-0.018578345,
-0.023153903,
-0.0103870435,
-0.0007030155,
0.027742611,
0.024508163,
0.009190561,
0.02724298,
-0.009578432,
0.027795203,
-0.021365754,
0.020497976,
0.01002547,
-0.021523532,
0.015370195,
-0.00039999158,
-0.030819278,
-0.0065970877,
0.0024241915,
0.0011479984,
0.0015917487,
-0.029977797,
0.022641126,
-0.026756499,
0.016882233,
-0.0075075976,
-0.014173713,
-0.018762419,
-0.047832992,
0.07310375,
0.027926685,
-0.01861779,
-0.0062683835,
0.011261396,
0.0007777956,
0.008697506,
-0.012858897,
0.006524773,
0.01761853,
-0.02553372,
-0.0022762746,
-0.008408247,
-0.007310375,
0.0067778747,
-0.019143716,
-0.023837607,
0.025717795,
-0.0145681575,
-0.003681484,
-0.018105011,
0.011721581,
0.011892508,
-0.012885193,
0.010669729,
-0.034342986,
0.02118168,
0.011346859,
-0.026901128,
0.0025293767,
0.009604729,
0.009144543,
0.01362149,
0.0108472295,
0.00050497137,
0.008112413,
-0.010452785,
-0.0049174107,
0.0057490314,
-0.013187601,
-0.02253594,
0.034053724,
0.0023633812,
0.001337825,
0.003773521,
0.014936306,
0.030530019,
-0.022982977,
-0.011478341,
-0.004621577,
-0.0070211156,
-0.000047893187,
-0.009815099,
0.04031225,
-0.052960776,
-0.015159825,
-0.012720842,
-0.008500284,
-0.0045196787,
-0.016237974,
0.014936306,
-0.012208063,
-0.01326649,
-0.024481868,
-0.0017519919,
-0.16387862,
0.006265097,
0.0048549566,
-0.008263617,
0.033922244,
0.0061829207,
-0.017053159,
-0.0005739992,
0.021733902,
-0.0017602094,
0.03252854,
-0.011103618,
-0.03045113,
-0.0138055645,
0.008342505,
-0.008552876,
0.022693718,
0.052724108,
0.026651314,
0.005985698,
0.026795942,
-0.03557891,
0.027637426,
-0.007310375,
0.005873939,
-0.008835562,
0.020866124,
0.004868105,
0.007573338,
-0.023561496,
-0.006192782,
-0.0047431975,
0.027164092,
0.013568898,
0.02475798,
-0.010452785,
0.006613523,
-0.019945754,
-0.016277418,
0.003075025,
0.042310767,
0.013871306,
-0.0029123167,
0.0058081984,
-0.0070079677,
0.019340938,
-0.0020543996,
-0.01055797,
0.02538909,
-0.007146023,
0.0048220865,
-0.027926685,
-0.00042813685,
0.03615743,
0.030687798,
0.02509983,
0.01005834,
0.016842788,
0.00035458934,
-0.008907876,
-0.008552876,
-0.007310375,
0.026638165,
-0.002935326,
0.018920198,
-0.00014832764,
0.015738344,
0.018933345,
-0.013365101,
0.003160488,
-0.026309462,
-0.019393532,
0.009164265,
-0.005643846,
0.0020330336,
0.008743525,
-0.0049272715,
0.012510471,
0.002268057,
0.016172232,
-0.009979451,
0.015133528,
-0.017842049,
-0.017842049,
-0.01690853,
0.00827019,
0.022207236,
0.014699639,
-0.0012162045,
-0.009966303,
0.012937786,
-0.029294092,
0.00841482,
-0.027479647,
0.03031965,
0.02795298,
-0.010347599,
0.00011268381,
-0.0012630448,
0.008072969,
0.0019147003,
0.0008801047,
-0.025730943,
0.015435936,
0.005532087,
-0.008796116,
-0.020103531,
-0.01062371,
0.01776316,
-0.02289094,
0.010005747,
0.0017026863,
0.03045113,
0.026572425,
-0.000008782557,
0.020445384,
0.0019722234,
-0.006863338,
0.005880513,
-0.03095076,
0.06484671,
0.006708847,
-0.0010666442,
0.021076495,
-0.0167639,
-0.02488946,
-0.1426312,
0.0044670864,
-0.0040890765,
-0.006600375,
-0.010617136,
0.008723802,
-0.012359267,
0.021339457,
-0.016579825,
0.01897279,
-0.04102225,
0.0035500024,
0.008178153,
-0.025980758,
-0.0067384304,
-0.0003944447,
0.018026123,
-0.0010978711,
-0.022483347,
0.025441684,
-0.006975097,
-0.010998433,
0.007198616,
-0.0045032436,
0.025849275,
0.010341025,
-0.025375942,
0.009151117,
0.013010101,
0.02482372,
0.019630197,
-0.010222692,
0.010807784,
0.011616397,
0.005551809,
-0.0117676,
-0.00060234993,
-0.024652794,
0.028847056,
0.0011019799,
-0.00620593,
0.004785929,
0.016435197,
0.0196039,
0.0026657889,
0.012543341,
-0.012569638,
0.000047122787,
0.007553616,
-0.038129654,
-0.018709827,
-0.027453352,
-0.04086447,
-0.028847056,
0.017368715,
0.009966303,
0.00027015354,
0.02703261,
-0.010492229,
0.014555009,
0.00013898012,
0.0144761205,
-0.014581306,
0.0035927338,
0.041890025,
-0.037761506,
-0.002979701,
-0.02861039,
0.016159084,
-0.020800384,
0.010866951,
-0.004023336,
-0.0042961603,
-0.028058166,
-0.0115769515,
-0.012687971,
0.0018275938,
-0.008776395,
-0.02260168,
-0.0056537073,
-0.020103531,
-0.015896121,
0.012747138,
-0.012385564,
0.019485569,
0.00019475707,
0.0009384497,
-0.00036034166,
0.013312508,
-0.012398711,
-0.0033577105,
0.025441684,
-0.0022631264,
-0.0052099572,
-0.0171189,
0.0039904653,
0.0030339372,
-0.007231486,
0.01690853,
0.036867432,
-0.02032705,
-0.00047662068,
-0.05385485,
0.02232557,
-0.020839829,
0.020366495,
0.0026131961,
-0.023850756,
-0.010492229,
-0.018381122,
0.013029823,
0.040680397,
-0.026980018,
0.001450406,
0.0017750012,
0.02680909,
-0.022785755,
-0.0038294005,
0.026901128,
0.0014980681,
0.0068436153,
0.006110606,
-0.013792416,
-0.008697506,
0.014436676,
-0.0023929644,
-0.016632417,
-0.0069488008,
-0.00891445,
0.024508163,
-0.015107232,
-0.014778528,
-0.011175933,
-0.024087423,
-0.015186121,
0.008046672,
-0.018696679,
-0.03973373,
-0.0044112066,
0.014370935,
0.026191128,
0.038261134,
-0.010544822,
-0.042547435,
-0.0008275121,
-0.019709086,
0.006304541,
-0.014042231,
-0.0062388005,
0.010380469,
0.00089078763,
-0.026493536,
0.05406522,
0.012517045,
-0.0074484306,
-0.039023727,
-0.023337979,
0.023219645,
0.0070737083,
-0.0069027822,
0.005147503,
-0.022509644,
0.017408159,
0.034342986,
-0.009335191,
0.040811878,
0.013279638,
-0.019669643,
-0.025849275,
0.014344639,
-0.0060119946,
-0.015370195,
-0.03166076,
0.0052691237,
0.010472506,
0.007126301,
0.02089242,
-0.0078560235,
0.005722735,
-0.0049831513,
-0.007803431,
0.019853717,
0.015804084,
0.012148897,
-0.0054696333,
0.010827507,
0.032870393,
0.0064984765,
-0.027085202,
0.045676697,
-0.022982977,
-0.0000974299,
-0.007566764,
0.0062913927,
0.02304872,
-0.0049174107,
0.022194088,
0.016724456,
0.004375049,
0.014949454,
0.009065654,
0.026953721,
0.028478907,
-0.0041876878,
0.0030405112,
-0.027611129,
0.0036387523,
0.029951502,
-0.038971137,
-0.018959641,
-0.004098938,
0.008408247,
0.028925944,
0.010308155,
-0.020629458,
-0.0051770867,
-0.034369282,
0.021602422,
0.00049346674,
-0.005387457,
0.005124494,
0.026440943,
0.026625017,
-0.0010740401,
0.010216118,
-0.0037998173,
-0.007698246,
0.02517872,
0.024665942,
-0.022312421,
0.0111825075,
0.0072840787,
0.005479494,
-0.0009803594,
-0.04236336,
0.00019023739,
-0.016132789,
-0.023232793,
0.011721581,
0.04522966,
-0.0017043299,
0.090985246,
0.0026805804,
-0.0038951414,
-0.0033692152,
-0.027637426,
0.014029083,
0.003270604,
0.026848536,
-0.011195655,
-0.033264834,
0.019958902,
-0.00039978613,
0.021839088,
-0.03510558,
-0.017224085,
0.0007794392,
-0.025901869,
0.013338805,
-0.0058344947,
-0.022417607,
0.027584832,
-0.0029517612,
0.0073169493,
0.024744831,
-0.026874833,
0.015869824,
0.03323854,
0.0031144696,
0.011787322,
-0.025783535,
0.017158344,
0.0067713005,
-0.0506467,
-0.0167639,
-0.0015136815,
0.0015933922,
-0.01874927,
-0.025441684,
0.0054729204,
0.010097784,
-0.024955202,
-0.00094255846,
-0.027479647,
-0.017276678,
0.00044539382,
-0.005048892,
-0.029609649,
-0.002973127,
-0.017381864
] |
In the present study, we constructed a lentivirus vector encoding the miR-29a precursor and established two stably infected cell lines, PLC-29a and 97L-29a. The overexpression of miR-29a was confirmed by TaqMan RT-PCR and significantly suppressed the growth of the hepatocellular carcinoma cell lines MHCC-97L and PLC. Dual-luciferase reporter assays indicated that the SPARC mRNA 3'UTR was directly targeted by miR-29a since the mutated 3'UTR was not affected. Silencing SPARC expression | [
-0.029693842,
-0.0076153325,
-0.0019435307,
-0.029984957,
-0.02694147,
0.0046743983,
-0.013682457,
-0.0023223124,
-0.018909313,
-0.0050746826,
0.025803471,
0.00060580263,
0.0030252917,
-0.002120516,
0.00591495,
0.021489661,
0.00944804,
-0.01603785,
0.014330851,
-0.010083203,
-0.008865808,
0.0063483156,
-0.023937682,
-0.036415976,
0.0021089376,
-0.0010404092,
0.0016970745,
-0.041100297,
-0.027788354,
0.005302944,
-0.008243878,
-0.013027445,
0.015071874,
0.0048530377,
-0.026584191,
0.008773181,
0.004353509,
-0.020470753,
0.012372434,
-0.001157021,
0.032208025,
0.022098357,
-0.003609178,
0.000147729,
0.005465043,
0.008455599,
0.033663604,
-0.012352585,
-0.0030186754,
0.031943373,
0.00573631,
0.00399623,
-0.018552035,
-0.004313811,
-0.009785471,
0.013265631,
0.006189525,
0.026663586,
-0.006692362,
-0.015468851,
-0.0012422056,
0.016593616,
-0.032657932,
0.0120747015,
-0.007972611,
0.019663569,
0.013735387,
-0.003466928,
0.012696631,
-0.008753331,
0.049939644,
0.011578481,
0.002552228,
-0.0015465543,
-0.024466984,
-0.034536954,
-0.015667338,
-0.010658818,
-0.0088922735,
0.002123824,
0.02704733,
0.004327044,
0.0007753447,
0.010162598,
0.030805375,
-0.013682457,
-0.0051441537,
0.022667358,
-0.0042211832,
0.0036786487,
0.026412169,
0.04655211,
0.0028979282,
0.009646528,
-0.020483987,
0.013563363,
0.0017301559,
0.051024713,
-0.00020923969,
-0.022852613,
-0.014621967,
-0.01266355,
-0.03170519,
-0.0092098545,
-0.014899851,
0.01609078,
0.0042244913,
-0.01209455,
0.027259052,
-0.013404572,
-0.02818533,
0.02403031,
0.005246706,
-0.033663604,
0.031122956,
-0.0053790314,
0.014913083,
-0.007304367,
-0.0076021,
-0.0011652914,
0.017744849,
0.01706999,
0.008224029,
-0.024877192,
0.032260954,
0.0087599475,
-0.01541592,
-0.0051838513,
-0.018975476,
0.010572807,
0.007277902,
0.025882866,
0.008885657,
0.013047294,
-0.0112476675,
0.0014861807,
-0.016408361,
-0.02076187,
-0.024202334,
-0.030964166,
-0.026041657,
0.03445756,
-0.0119489925,
-0.00020882617,
-0.005130921,
-0.025763774,
0.00461816,
-0.01681857,
0.0068743094,
0.011479237,
0.002021272,
-0.02776189,
0.02029873,
-0.006040659,
0.015852595,
0.0016921123,
-0.007509472,
0.025075682,
-0.016924432,
-0.009282634,
0.010162598,
0.0009742465,
0.026557727,
0.015508548,
-0.009315715,
0.025737308,
0.021039754,
-0.0027010941,
-0.0068015303,
-0.021582289,
0.00011102936,
0.028370587,
-0.029058678,
0.008799645,
-0.00804539,
0.0024728328,
-0.0078866,
0.01209455,
-0.008839343,
-0.017546361,
-0.03072598,
0.023501009,
0.021674916,
0.00433366,
-0.0043998226,
0.0076153325,
0.011724039,
-0.014502875,
0.001299271,
-0.027259052,
-0.013020828,
0.0037150383,
0.020325197,
-0.013828014,
-0.6258467,
-0.047187272,
0.0017913564,
0.009103994,
-0.0059546474,
0.032525606,
0.005613909,
-0.012180562,
-0.02626661,
0.0168715,
-0.021820474,
0.010122901,
-0.000025470074,
-0.0005656915,
-0.0015209161,
-0.027179657,
-0.018141825,
-0.00036803028,
0.024056775,
0.0016888041,
-0.026915006,
0.008257111,
0.008548227,
0.008806262,
-0.021939566,
0.024162635,
0.024983054,
-0.01557471,
0.004260881,
0.0366277,
-0.010341237,
0.03175812,
-0.010711749,
-0.020179639,
0.04067686,
-0.011035946,
-0.0116909575,
0.00573631,
0.0033627218,
0.015812896,
-0.029217469,
-0.013530282,
0.022032196,
-0.017506663,
-0.02694147,
0.008415901,
0.009051064,
-0.013503817,
-0.0054021883,
-0.020285498,
0.022389473,
0.011174888,
-0.04358802,
-0.023223124,
-0.00071083603,
0.011869597,
0.03877137,
-0.019994382,
0.015151269,
0.018419709,
0.0072646695,
0.038374394,
-0.005991037,
-0.011274132,
-0.0044428287,
-0.016831802,
-0.008627622,
0.01085069,
0.020219335,
0.004631392,
0.020219335,
0.030646585,
-0.0016780527,
-0.0035297826,
0.017943338,
0.03522505,
-0.009534052,
0.00009877892,
-0.0054286537,
0.015151269,
-0.0018575191,
-0.027100261,
-0.042317692,
0.003007097,
0.006232531,
0.0125179915,
-0.051236432,
0.032049235,
0.00021585597,
0.015495315,
0.026570959,
0.011499085,
-0.009646528,
-0.031996306,
-0.021767544,
-0.00085432647,
-0.021621985,
-0.010513261,
0.007674879,
-0.017996266,
-0.0063681644,
0.00087500236,
0.022508567,
-0.023209892,
0.029349795,
-0.013020828,
-0.03083184,
0.0044891424,
0.015998153,
-0.042688206,
0.019345988,
0.006401246,
0.006186217,
-0.02403031,
0.010056738,
-0.030911235,
0.017903639,
0.005197084,
-0.014820456,
-0.03519858,
0.019994382,
-0.00861439,
0.023077566,
0.017215546,
-0.018697593,
0.00884596,
0.0083762035,
0.0010056738,
0.004720712,
0.002552228,
0.025988728,
-0.003681957,
0.048589922,
-0.024678705,
0.019584173,
-0.012279806,
0.0038407475,
0.019544475,
0.00804539,
-0.020576615,
-0.036707092,
-0.015270363,
-0.0013158116,
-0.0013464119,
-0.004829881,
-0.016130477,
-0.0015680571,
-0.0034173059,
0.010281691,
-0.00008420243,
-0.0034967011,
-0.03186398,
0.008448983,
0.007304367,
0.018697593,
-0.004426288,
-0.0011843132,
-0.028449982,
-0.00641117,
-0.028794028,
0.0030898002,
0.022442404,
-0.00944804,
0.008138018,
0.0059744962,
-0.022085125,
0.01468813,
-0.00067113835,
-0.0153894555,
-0.028952818,
0.0128421895,
-0.006715519,
-0.002868155,
0.007608716,
-0.0075028557,
-0.017321408,
-0.010777911,
0.00072324154,
0.0005313696,
-0.021608753,
0.013364875,
0.004211259,
0.0056238337,
-0.010672051,
0.0050978395,
0.027629564,
0.03535737,
0.018671127,
0.042291228,
0.018075664,
-0.024400821,
0.016183408,
-0.0049192,
0.04168253,
0.0080586225,
-0.019147499,
0.013225934,
0.016156944,
0.032869652,
0.004641317,
0.011049178,
-0.012934817,
-0.00022826147,
-0.02900575,
0.0071455766,
-0.019637104,
-0.007787355,
-0.009441424,
0.0025952337,
-0.0045718458,
0.014595502,
-0.00079271244,
-0.024466984,
-0.018512337,
0.0061696763,
0.007496239,
0.0033759542,
-0.016765641,
-0.021939566,
-0.023421613,
0.005908333,
0.008998133,
-0.0036455675,
-0.0042972704,
-0.0026068122,
-0.0015002403,
-0.006814763,
0.030752445,
-0.001157021,
-0.0054617347,
-0.010063354,
-0.00077575824,
0.00905768,
0.01795657,
0.022138055,
0.024070008,
0.0035992535,
-0.014807223,
0.03062012,
0.011843132,
-0.028397052,
0.012372434,
-0.017400803,
-0.0011743888,
0.011022714,
-0.01619664,
0.0072580534,
0.016368663,
-0.020179639,
0.015548246,
-0.005713153,
0.0043898984,
-0.020986823,
-0.010678668,
-0.0015771545,
-0.021410266,
-0.00413848,
0.005130921,
0.05552378,
0.018882848,
0.027444309,
-0.000011649554,
0.007860134,
-0.017678685,
0.01124105,
0.024215566,
0.009295866,
-0.010903621,
-0.009725924,
0.010261842,
-0.023501009,
-0.0048927353,
0.012570922,
-0.047425456,
0.0068412283,
0.0006004269,
-0.013133305,
0.023553938,
0.011664492,
0.022879079,
-0.030752445,
-0.028502911,
0.027259052,
-0.0025968878,
-0.005898409,
-0.017903639,
-0.037236396,
-0.0120747015,
-0.011432922,
-0.000099605946,
-0.010241994,
0.009666378,
0.0070198677,
0.004035928,
-0.016011385,
-0.015111571,
0.027338447,
-0.03850672,
0.021780776,
-0.007079414,
-0.013708921,
-0.005802473,
-0.010122901,
-0.015071874,
0.04245002,
-0.00799246,
0.018459406,
0.0000042579345,
-0.0030815299,
-0.007483007,
-0.005828938,
-0.0029822858,
0.00020965321,
-0.0048067234,
-0.00080346386,
0.010195679,
0.013192852,
0.008018925,
0.026412169,
0.016897965,
-0.009362029,
-0.029058678,
-0.001902179,
-0.002310734,
0.010440482,
0.038427323,
0.0027126726,
-0.003151001,
0.008283576,
0.010546342,
-0.0061465194,
-0.028714633,
0.023527473,
-0.00861439,
-0.016633315,
-0.007985843,
-0.025512356,
-0.017083222,
0.021211777,
0.01863143,
0.005590752,
-0.02403031,
-0.0009246244,
-0.008296808,
0.02294524,
0.0041814856,
0.014833688,
0.03498686,
0.028476447,
-0.020748638,
0.011227818,
0.020470753,
0.022852613,
0.009825168,
0.005924874,
0.010480179,
0.009428192,
0.015111571,
0.016408361,
-0.020245802,
0.01884315,
0.015323292,
-0.0024248648,
0.031811047,
0.019226894,
0.030249609,
0.014569037,
0.006434327,
0.00037506007,
0.0060505834,
-0.009322331,
0.00015692976,
-0.004016079,
-0.019928219,
0.03331956,
-0.005326101,
-0.009368645,
0.0012604004,
0.0033213699,
0.010023656,
-0.022561496,
0.0065567284,
0.0006496355,
-0.007833669,
-0.027947145,
-0.02356717,
0.016924432,
-0.0006665897,
0.0045817704,
-0.023673031,
0.009368645,
-0.008799645,
-0.0048034154,
-0.018287383,
0.0018194756,
-0.007363914,
-0.03062012,
-0.0010031926,
0.005319485,
0.027285516,
0.016117245,
-0.0037381952,
0.007840286,
0.03503979,
-0.005537822,
-0.028476447,
0.0030765678,
-0.031122956,
-0.008005693,
-0.021145614,
-0.0011164964,
-0.0056899963,
-0.036812954,
-0.008918738,
0.002626661,
0.0032667858,
0.021939566,
-0.0032436287,
-0.012637085,
0.0026547802,
0.03056719,
0.0054782755,
-0.011982074,
0.009044448,
0.0031642334,
-0.028211795,
-0.022865845,
-0.032102164,
-0.019742964,
-0.025260936,
0.021476427,
0.021846939,
-0.026835611,
-0.030514259,
0.011128575,
0.015442385,
-0.003370992,
0.014238223,
0.017969802,
0.008680552,
0.010162598,
-0.0123922825,
0.0006049756,
-0.005819014,
-0.01920043,
-0.010731597,
0.026041657,
-0.01587906,
-0.016236339,
0.013517049,
0.017268477,
-0.02205866,
-0.026716517,
0.007152193,
0.0029210853,
0.058434937,
0.0020047312,
-0.01479399,
-0.023421613,
-0.009381877,
-0.004958898,
-0.0054319617,
-0.00013708095,
-0.027232587,
-0.03331956,
0.0120747015,
-0.013867712,
-0.00076831493,
-0.00038022903,
-0.02776189,
0.0016292577,
0.032287423,
0.019187197,
-0.013933875,
-0.007588867,
0.0064839493,
-0.04083565,
-0.0069404724,
-0.027523704,
-0.025657913,
-0.0024017077,
0.000012831954,
0.05091885,
0.0014787375,
0.02564468,
-0.029826166,
0.00083861285,
-0.0045950026,
0.021397032,
-0.002792068,
-0.01141969,
0.011611562,
0.0089518195,
0.02241594,
0.035436768,
0.008925355,
0.014105897,
-0.011624794,
-0.0011148422,
0.017519895,
-0.014860153,
0.00074433093,
0.0011917565,
-0.023315752,
-0.036363047,
0.005723078,
-0.01863143,
0.009646528,
-0.03294905,
-0.021476427,
0.013788316,
-0.0064839493,
0.016448058,
-0.0045122993,
0.013404572,
-0.0085680755,
0.013265631,
-0.015376222,
-0.00015920411,
-0.0012496489,
0.012557689,
-0.010189063,
-0.0028449981,
0.0016176791,
-0.005924874,
0.0021519433,
0.015442385,
-0.014158828,
-0.007965995,
0.028582307,
-0.013100224,
-0.00905768,
-0.016792106,
-0.028502911,
-0.02600196,
-0.025499122,
-0.010334621,
-0.027894214,
0.002671321,
0.02584317,
-0.015230665,
0.008144634,
-0.0070198677,
0.005322793,
0.023527473,
0.011307213,
0.023845054,
-0.0073176,
0.033187233,
0.018234454,
-0.0056006764,
-0.017930105,
0.0020841265,
0.0100368885,
-0.009051064,
0.025075682,
0.044567227,
-0.019054871,
-0.007277902,
0.023646565,
0.009553901,
-0.0047537936,
-0.036654163,
0.03239328,
0.002262766,
-0.0062259147,
-0.018604964,
-0.021992497,
-0.016937664,
0.017612524,
-0.00991118,
-0.0022908852,
-0.010486796,
0.00046396628,
-0.0076219486,
0.027232587,
0.0021304404,
0.01598492,
-0.0014167099,
-0.027153192,
-0.010083203,
-0.02942919,
0.021674916,
-0.009322331,
-0.011327063,
0.04395853,
-0.0016871501,
-0.00905768,
0.004525532,
-0.008905506,
-0.0012868654,
-0.012213644,
0.0017003826,
0.038374394,
-0.0006525301,
0.0011983728,
0.010202296,
-0.012451829,
0.026306309,
0.003055065,
0.006887542,
-0.024718402,
-0.01237905,
0.012630468,
0.0320757,
0.020219335,
-0.012987748,
-0.0073572975,
-0.00832989,
-0.0028499605,
-0.01775808,
-0.03803035,
0.022349777,
-0.039935835,
-0.009699459,
-0.010440482,
0.007979227,
0.024361124,
0.015402688,
-0.007681495,
-0.0021023212,
0.032869652,
-0.021304404,
-0.0035099338,
0.0092694005,
-0.018102128,
-0.030381933,
0.0054617347,
-0.0057495427,
-0.018247686,
0.01261062,
-0.038427323,
-0.015852595,
-0.046022806,
-0.011062412,
0.021992497,
0.021026522,
0.006285461,
0.04747839,
-0.0027738733,
0.0061332867,
0.00037547358,
0.013067143,
0.024890427,
-0.03130821,
0.016302502,
-0.0040987823,
-0.007965995,
0.0110557955,
-0.021145614,
-0.028952818,
0.001637528,
-0.0320757,
-0.009917796,
-0.008865808,
-0.00022412631,
-0.026319541,
-0.008409285,
-0.014569037,
-0.002213144,
-0.005726386,
0.0032899426,
0.009878098,
-0.015799664,
-0.01474106,
0.0013389686,
0.011783585,
0.009242936,
-0.011909295,
0.0011917565,
0.022455636,
-0.017665453,
-0.028449982,
-0.013364875,
-0.033875328,
0.0041980264,
0.0029012365,
0.0010949934,
-0.025075682,
-0.007820437,
-0.062034193,
0.009355413,
0.013814782,
0.014807223,
0.006861077,
0.011320446,
0.0014621967,
0.0013108494,
-0.013550131,
0.008415901,
0.012068085,
-0.02564468,
-0.009778854,
-0.025141845,
0.027232587,
0.008647471,
-0.02818533,
-0.0068412283,
0.022468869,
0.024665473,
-0.01795657,
0.014873385,
-0.025790239,
-0.0012198756,
-0.019372452,
-0.0047637178,
-0.0082504945,
0.006474025,
0.015045409,
-0.019557709,
-0.020722173,
0.008455599,
0.009931029,
-0.0168715,
-0.00084233447,
-0.0018277459,
0.0185785,
0.02179401,
0.010605888,
-0.027841285,
0.014529339,
-0.010943319,
0.00019507673,
0.0071654255,
0.040412206,
0.022548264,
0.021635218,
0.0018161674,
-0.013060526,
0.008786413,
0.00591495,
0.0046843225,
0.009176773,
0.01806243,
0.0024447136,
-0.0009122189,
-0.016805338,
-0.010658818,
-0.019888522,
0.019240128,
-0.011803434,
-0.030223142,
0.0098384,
-0.005819014,
-0.01380155,
-0.00804539,
0.0065831933,
-0.01474106,
-0.0063582403,
-0.005948031,
-0.00698017,
-0.008654088,
0.00081462885,
-0.010063354,
-0.012623852,
0.010202296,
0.005994345,
0.004843113,
0.010447098,
0.008806262,
0.19869997,
-0.0005346777,
0.009454656,
0.013510433,
0.000057840716,
-0.0048563457,
0.025313867,
0.014397014,
-0.0039664567,
-0.0024215565,
0.0072514373,
-0.0019534552,
-0.007780739,
-0.0046082353,
0.0080586225,
-0.009295866,
-0.032260954,
-0.0057660835,
-0.043005787,
-0.015680572,
-0.0032303962,
-0.011360144,
0.02117208,
-0.0015349757,
0.020325197,
0.01769192,
-0.040915042,
0.013272247,
0.02013994,
0.012167329,
-0.016527455,
0.018909313,
-0.016342198,
0.010506644,
0.0019799203,
0.01587906,
-0.012855422,
0.00641117,
0.0034040734,
0.005101148,
-0.014542572,
0.0057859323,
-0.009752389,
-0.015257129,
-0.0071455766,
0.0052103163,
-0.0063383915,
-0.0022908852,
0.0130340615,
-0.005819014,
-0.040332813,
0.033028442,
0.033875328,
0.024122939,
-0.014224991,
0.0021999113,
0.01884315,
0.015283595,
0.006526955,
0.030964166,
-0.00433366,
0.004740561,
-0.011406458,
0.0046743983,
-0.021066219,
0.022363009,
0.004932433,
-0.0067320596,
0.0168715,
-0.014807223,
0.017109687,
-0.014992478,
-0.009401727,
0.01165126,
-0.011538783,
-0.011512318,
0.039221276,
0.015257129,
0.008151251,
0.011578481,
0.02122501,
-0.007959379,
-0.034801606,
0.00047347715,
-0.0030666434,
-0.035569094,
0.015257129,
-0.0039829975,
-0.014211758,
-0.0029442422,
0.0146352,
-0.021145614,
-0.009183389,
-0.021767544,
0.012862038,
0.011181504,
0.0053360257,
-0.0005284749,
0.0075227045,
-0.028502911,
-0.014939548,
0.060710937,
0.00062482443,
0.014357316,
0.012412132,
0.0062920772,
-0.006209374,
-0.013007596,
0.012742945,
-0.011499085,
0.012187178,
-0.03975058,
0.0078866,
-0.011942376,
-0.0077608903,
0.021092683,
0.029455656,
-0.031572863,
0.043455694,
-0.0044196714,
0.004039236,
0.015826128,
-0.0034206142,
0.024665473,
0.00011071922,
0.0064872573,
-0.038427323,
-0.0070198677,
-0.014317619,
-0.030487794,
0.001948493,
0.0005330236,
0.008448983,
0.014661665,
0.011571865,
-0.0014167099,
0.019041639,
0.0041914103,
0.0035099338,
-0.00069016014,
-0.006493874,
-0.017361104,
0.016884733,
0.015018944,
-0.018710826,
-0.000566932,
0.023805358,
0.02076187,
0.0034702362,
-0.018207988,
-0.033451885,
-0.01827415,
-0.020259034,
-0.004925817,
0.021767544,
0.00088244566,
-0.02948212,
-0.01639513,
-0.031440537,
0.02444052,
-0.04464662,
0.007489623,
0.011168272,
-0.007588867,
-0.016778873,
-0.007344065,
-0.16620082,
-0.0034967011,
0.016077548,
-0.025049217,
0.023315752,
0.028899888,
0.004839805,
-0.019134266,
-0.007396995,
0.0069934023,
0.023117265,
0.0037415035,
-0.027364913,
-0.01749343,
0.0032816723,
-0.0032122014,
-0.004525532,
0.029111609,
0.040147554,
0.0014836997,
0.036839418,
-0.016130477,
-0.017586058,
-0.017837476,
-0.0125246085,
0.022389473,
-0.014754293,
-0.01660685,
-0.008118169,
-0.011823283,
-0.002017964,
0.02170138,
0.0025886176,
-0.028767563,
0.017321408,
-0.004535456,
-0.00014638508,
0.01722878,
-0.004889427,
0.020748638,
0.030249609,
0.011545399,
-0.0022743444,
-0.0002900823,
-0.026319541,
0.060869727,
0.015071874,
-0.010672051,
0.018644663,
-0.0024893733,
0.010109668,
-0.037924487,
0.0422383,
0.014449944,
0.018869616,
0.016752407,
0.0043468927,
0.005729694,
0.01863143,
-0.01209455,
-0.021357335,
-0.018763755,
0.036019,
-0.0088922735,
0.014105897,
-0.03795095,
-0.008707018,
0.01541592,
-0.039697647,
0.013894177,
-0.029349795,
0.0013646067,
-0.0069272397,
-0.0001248822,
0.007483007,
0.021211777,
-0.0072448207,
0.035330907,
-0.0071852743,
-0.004307195,
-0.014304386,
0.014926316,
-0.011922527,
-0.0051441537,
0.0055775195,
0.002911161,
0.014767526,
0.02008701,
-0.0024678705,
-0.008660704,
0.005223549,
-0.022971706,
-0.016845036,
-0.012233492,
0.025049217,
0.014966014,
0.004313811,
0.009262784,
-0.010533109,
0.0058587114,
0.01733464,
-0.02834412,
-0.006788298,
0.0113733765,
0.014463177,
-0.013490585,
-0.03752751,
0.019438615,
0.065686375,
-0.02502275,
0.00046024463,
0.0025869634,
0.014397014,
0.0098384,
-0.009190005,
0.010394168,
-0.002358702,
-0.01087054,
-0.010281691,
-0.029879097,
0.053009592,
0.007224972,
0.004621468,
0.023421613,
0.008475448,
-0.024321426,
-0.1170816,
-0.04266174,
0.035463233,
0.029852632,
-0.022018962,
0.042423554,
-0.010493412,
0.04043867,
-0.011671109,
0.01909457,
0.0051838513,
-0.015230665,
0.006189525,
-0.0068279956,
0.0011752158,
-0.02003408,
0.010824226,
0.004532148,
-0.01401327,
0.040729787,
0.0062689204,
0.007172042,
-0.02294524,
-0.01775808,
0.0029442422,
0.00698017,
-0.004340276,
0.015323292,
0.028582307,
0.018234454,
0.0005512184,
-0.00037175193,
0.019041639,
0.010136133,
-0.035939604,
-0.023831822,
-0.030964166,
-0.0030848382,
0.016686246,
-0.026756216,
0.021516126,
0.0035496315,
-0.004161637,
-0.005587444,
0.019703267,
-0.0140662,
-0.016514221,
0.017930105,
0.018949011,
-0.016593616,
-0.025962261,
-0.011042562,
-0.016130477,
-0.019769428,
0.011346911,
-0.026822379,
0.03411351,
0.03554263,
-0.024903659,
-0.018432941,
0.005230165,
0.0028995825,
0.008786413,
-0.010486796,
0.014158828,
-0.0071124956,
0.00002651679,
-0.03466928,
0.03959179,
-0.013014212,
-0.010308156,
-0.0010304848,
-0.0071124956,
0.007363914,
-0.0040789335,
-0.008819494,
-0.012147481,
-0.037236396,
0.007800588,
-0.0051739267,
-0.023395147,
-0.022018962,
0.007191891,
-0.028608773,
0.014886619,
-0.007860134,
0.0035099338,
-0.013775084,
0.0043733576,
0.0071191117,
0.0005599022,
0.04178839,
-0.009137075,
-0.0320757,
-0.028873423,
0.013629526,
0.0037216546,
0.005848787,
0.008978285,
0.03445756,
-0.011975457,
-0.022720288,
-0.06452191,
0.016540688,
0.0050846073,
-0.0044924505,
0.0075690183,
-0.032446213,
0.0017533128,
-0.008766565,
-0.014330851,
-0.0015333217,
-0.040041696,
0.00073647406,
-0.0020890888,
0.0025439577,
-0.020629546,
0.014621967,
0.031070026,
-0.008085088,
0.007496239,
0.03855965,
0.0027060565,
-0.006219298,
-0.01889608,
0.014000038,
-0.023792123,
-0.012921585,
0.017731616,
0.02356717,
-0.0123327365,
-0.019967917,
-0.0069404724,
-0.027391378,
-0.016077548,
0.020113476,
-0.0061663683,
-0.039433,
0.0121408645,
0.021039754,
0.022746753,
0.016752407,
-0.029561516,
-0.035727885,
0.002266074,
0.019293057,
0.016011385,
0.020073777,
-0.014264689,
-0.00031716767,
0.009256168,
-0.02834412,
0.03083184,
0.010678668,
-0.013523665,
-0.017400803,
-0.010791144,
-0.006672513,
-0.017347872,
-0.014397014,
-0.014555804,
-0.013907409,
0.027232587,
0.004697555,
0.0016987285,
0.017308176,
0.018776989,
0.002600196,
-0.026451867,
-0.0023802049,
0.017930105,
-0.015839363,
-0.011803434,
-0.00048464214,
0.007780739,
-0.010116284,
0.0066526644,
-0.00591495,
-0.0031179194,
0.022363009,
-0.005971188,
0.007588867,
0.009606831,
-0.009739157,
-0.00041062254,
0.016249571,
0.03975058,
0.024215566,
0.013841247,
0.019398918,
-0.00030083375,
0.0018641354,
0.01603785,
0.00884596,
0.0022478793,
-0.0015647489,
0.004310503,
0.028635237,
0.008746715,
-0.0010643932,
0.0005814051,
0.008548227,
0.0027622946,
0.0077410415,
0.0048761945,
-0.035119187,
-0.0009800358,
0.01831385,
-0.0253271,
-0.03413998,
0.027153192,
0.00260185,
0.008025541,
0.0025588442,
-0.0022544956,
0.021013288,
-0.005508049,
0.007535937,
-0.005733002,
-0.016328966,
0.0068743094,
0.03596607,
0.023276055,
0.012961282,
0.014423479,
0.0032899426,
0.0018459407,
0.015098339,
0.035489697,
-0.024122939,
0.020126708,
-0.02127794,
0.018168291,
0.0025472657,
-0.012478294,
-0.031334676,
-0.013735387,
-0.000686025,
-0.019597406,
-0.00568338,
-0.0017863942,
0.083523855,
0.016328966,
-0.02958798,
-0.013841247,
-0.022508567,
0.028423516,
0.011267516,
0.007483007,
-0.023964148,
-0.027338447,
0.0056536067,
-0.011552015,
0.013655991,
-0.062828146,
-0.019531243,
0.0018409785,
0.0060737403,
0.016831802,
-0.020285498,
0.003850672,
0.0006144865,
0.020894196,
-0.0012678436,
0.010652202,
-0.038374394,
0.0060737403,
0.038268533,
-0.012068085,
0.003969765,
-0.039406534,
-0.0002565874,
0.013166387,
-0.03170519,
-0.02019287,
0.025710844,
-0.003830823,
-0.015283595,
-0.017784547,
0.04271467,
0.013146538,
-0.00076004455,
0.008455599,
-0.015627641,
-0.0056767636,
0.020563383,
-0.010969783,
-0.008263728,
-0.02065601,
-0.005197084
] |
Injured axons of the adult CNS undergo lengthy retraction from the initial site of axotomy after spinal cord injury. Macrophage infiltration correlates spatiotemporally with this deleterious phenomenon, but the direct involvement of these inflammatory cells has not been demonstrated. In the present study, we examined the role of macrophages in axonal retraction within the dorsal columns after spinal cord injury in vivo and found that retraction occurred between days 2 and 28 after lesion and that the ends of injured axons were associated with ED-1+ cells. Clodronate liposome-mediated depletion of infiltrating macrophages | [
-0.01665894,
0.0065846927,
-0.0023129988,
-0.038505413,
-0.017260587,
0.0086369775,
-0.0022896014,
0.0013119249,
0.00070818875,
0.0028377688,
0.023731634,
0.027034009,
-0.002480123,
0.029092979,
-0.013115906,
-0.0008857582,
0.04112592,
0.034173552,
-0.013135961,
-0.0006262979,
-0.02060307,
0.02671313,
-0.017126886,
0.0010804578,
0.02054959,
0.0021926693,
-0.005374714,
-0.016993187,
-0.0023681498,
-0.01853073,
-0.0054549333,
-0.01632469,
-0.002369821,
-0.005244357,
-0.018891718,
-0.00615017,
0.019653805,
-0.029173197,
0.00044956408,
0.017608205,
0.033799194,
-0.0019653805,
-0.0059529636,
0.013851252,
0.021726144,
0.005274439,
-0.021057647,
-0.017808754,
-0.0015918579,
0.02080362,
0.029306898,
-0.00036077935,
-0.008730567,
-0.0018483935,
-0.0052276445,
-0.03687428,
-0.0022478204,
0.0225016,
0.0072665596,
-0.017126886,
0.0059462786,
0.0011356089,
-0.009820217,
0.02246149,
-0.02050948,
0.012567739,
-0.0049769585,
-0.0011322664,
-0.0032589217,
-0.009452544,
0.033451576,
0.030590411,
-0.0008715526,
-0.021177977,
0.01669905,
-0.014934218,
-0.01435931,
-0.002653932,
0.022167353,
0.0055786055,
0.015763152,
-0.03746256,
-0.010929922,
0.03518967,
0.022782369,
-0.02079025,
0.010087616,
0.006822009,
-0.024894819,
-0.0077478774,
0.0015776523,
0.022073762,
0.021699404,
0.01341673,
0.0105555635,
0.013142646,
-0.014586599,
0.023357276,
-0.015816633,
-0.0098603275,
-0.02682009,
-0.008509964,
-0.028130343,
-0.02267541,
-0.027889684,
0.018851608,
0.015562604,
0.0011097046,
0.032542422,
0.011832393,
-0.012413984,
0.037917137,
0.0021709432,
-0.048559602,
0.009980656,
-0.0055719204,
0.027314777,
0.009198516,
-0.0013085824,
-0.013222866,
-0.0062972396,
0.037302118,
-0.0063808016,
-0.035483807,
0.025870824,
0.015923593,
-0.013684128,
0.0137041835,
-0.017795384,
0.0037001295,
0.0013369935,
0.0071128053,
0.032622643,
0.0028010013,
0.0012818425,
0.029039498,
-0.030536931,
-0.012253545,
-0.04168746,
-0.031258907,
-0.0014556517,
0.017755274,
-0.008550073,
-0.010936607,
-0.005658825,
0.009893752,
0.039548267,
-0.007574068,
0.01857084,
0.018102892,
0.00025340205,
-0.046527375,
0.0030383177,
-0.019854354,
0.0006262979,
0.008616923,
-0.0014940902,
0.02874536,
-0.02036241,
-0.018677799,
-0.0068086395,
-0.01223349,
0.012627903,
-0.013450154,
0.004773067,
0.019439885,
-0.0026656308,
0.026231812,
0.022153983,
-0.01640491,
0.0010044164,
0.036713842,
0.007206395,
0.014827258,
0.0015667892,
0.014198871,
0.001357884,
0.015669564,
-0.020429261,
-0.0062237047,
-0.035724465,
-0.0040042954,
0.03147283,
-0.010809592,
-0.01030822,
0.011177266,
0.036259264,
-0.021004168,
-0.01145135,
-0.030429972,
-0.004539093,
0.026191702,
-0.021739515,
-0.0079417415,
-0.63277227,
-0.015589344,
0.017594835,
0.0010386768,
0.0039641857,
0.017367546,
-0.00810218,
-0.020041533,
-0.021940064,
0.0287721,
-0.011966092,
0.029467337,
0.015776522,
-0.0073200394,
-0.01660546,
-0.004415421,
-0.016752528,
0.009385695,
0.027461845,
0.00022248407,
0.005872744,
-0.007808042,
-0.003004893,
0.016297951,
0.015642824,
0.011712063,
0.02243475,
-0.025122108,
-0.010395125,
0.012895302,
-0.022809109,
0.006220362,
0.0022611902,
-0.0035965126,
0.04770393,
-0.00006355942,
-0.015669564,
0.018209852,
0.008362894,
0.024172843,
-0.016886229,
-0.005708962,
-0.0043786536,
-0.029226677,
-0.012460779,
0.0049502184,
-0.008429744,
0.010482029,
0.0012417327,
-0.009612983,
0.023691524,
0.018610949,
-0.024827968,
-0.010047507,
0.024908189,
0.009198516,
0.021137867,
-0.0016060635,
0.0033408124,
0.0112574855,
0.00036119716,
0.009392379,
-0.009051446,
-0.013864622,
-0.0065312134,
0.0033341276,
-0.032141324,
0.001212486,
0.027034009,
0.0058794287,
0.016271211,
0.025763864,
0.015067916,
0.0018651059,
0.0049569034,
0.031633265,
-0.015348685,
0.021645924,
-0.015642824,
0.01664557,
-0.02656606,
-0.005996416,
-0.01632469,
0.015228356,
0.019854354,
-0.012868563,
-0.019988053,
0.01024137,
-0.0053011794,
-0.0029748105,
-0.009038076,
0.003421032,
-0.028504701,
-0.052624065,
-0.012721493,
0.031098468,
-0.012153271,
0.012694753,
0.003289004,
0.003807089,
-0.009833587,
0.013664073,
0.025028517,
-0.000006110478,
0.023584565,
0.009940547,
-0.036098823,
0.011003456,
0.054014537,
-0.036339484,
0.021806363,
0.0063741165,
0.0006016471,
-0.022849219,
0.003967528,
-0.016070662,
-0.0015926935,
0.0019319556,
-0.027328147,
-0.022809109,
0.011504829,
-0.018183112,
-0.009572874,
0.015308576,
0.019947942,
0.005358001,
0.007861522,
-0.008630293,
-0.0057457294,
-0.016084032,
-0.010615728,
-0.0017297353,
0.023758374,
-0.017594835,
0.013129276,
0.034039855,
0.011491459,
-0.009846957,
0.0046961894,
-0.044120785,
-0.05307864,
0.007654288,
0.0014355967,
-0.021432005,
0.003793719,
-0.01669905,
-0.023036398,
0.017247217,
0.0060365256,
0.009238625,
0.0012785001,
0.0077010826,
0.0070593255,
0.0065412405,
0.018209852,
-0.005591975,
-0.012360505,
-0.02472101,
-0.0023230263,
-0.01826333,
-0.04069808,
0.019078897,
0.011297595,
0.033558536,
-0.016057292,
-0.041847896,
0.010943292,
0.020242082,
0.0019653805,
-0.03885303,
0.0043853386,
-0.02243475,
-0.011063621,
-0.004422106,
-0.0137041835,
-0.0089912815,
0.012159956,
0.0013169385,
-0.011819023,
0.008730567,
0.017501244,
-0.006424254,
0.018062782,
-0.0035296627,
0.024079252,
0.028451221,
0.017113516,
0.003947473,
0.0102146305,
0.021378526,
-0.02885232,
0.004609285,
-0.017902343,
-0.0017665026,
-0.003233853,
-0.031766966,
-0.007420314,
0.025015147,
0.006009786,
0.015629454,
0.005404796,
-0.011812338,
-0.001728064,
0.016912967,
0.028210564,
-0.006811982,
-0.008951171,
-0.037783436,
0.024373392,
-0.004532408,
0.0005347974,
-0.008971226,
-0.0029046184,
-0.016872859,
0.0022745603,
0.011337705,
0.0065412405,
-0.013563799,
-0.008028646,
0.010348329,
-0.006668255,
-0.009806847,
0.02260856,
0.002480123,
-0.019814244,
0.019239336,
0.0066849673,
0.023343906,
-0.0055786055,
-0.020977428,
0.012213436,
0.026405621,
0.0062404172,
0.015228356,
0.020148491,
0.022795739,
-0.0040945425,
-0.003827144,
0.029975394,
0.020669919,
0.0033642098,
0.045939095,
-0.00019469968,
-0.00026134044,
-0.023704894,
-0.014626709,
0.027488586,
0.012139901,
0.00619028,
0.02065655,
-0.007600808,
-0.0015208301,
0.012373875,
-0.022260942,
-0.009746683,
-0.025269177,
0.0022745603,
0.014947588,
0.021204717,
0.03486879,
0.008162345,
-0.031873927,
0.012447409,
-0.031071728,
0.024253061,
-0.0100408215,
0.010742743,
0.0032990314,
-0.0037836917,
-0.012962152,
-0.03700798,
-0.00009578305,
0.0128284525,
-0.032462202,
0.017434396,
0.027034009,
0.02060307,
-0.005431536,
0.025549946,
0.0117789125,
-0.023544455,
-0.040056325,
0.009131665,
0.015736414,
-0.006591378,
0.0009208543,
-0.010548878,
0.004000953,
0.0071328604,
0.01230034,
0.0027441792,
-0.008042016,
-0.008489909,
-0.011491459,
-0.01433257,
-0.0065111583,
0.038104314,
-0.01651187,
0.020776879,
-0.024052514,
0.013102536,
-0.0048198616,
-0.030429972,
-0.00015135184,
0.034146816,
0.000014440574,
0.007045956,
-0.0268602,
-0.01660546,
-0.031044988,
0.006999161,
-0.02262193,
-0.0006639008,
0.008830842,
-0.013156016,
0.006086663,
-0.005030438,
-0.0057824966,
0.028157083,
0.0048967386,
-0.000630476,
-0.021151237,
0.010749428,
-0.031873927,
0.027221188,
0.03323766,
-0.0072531896,
0.013717554,
-0.004351914,
0.01223349,
0.014640079,
-0.013343195,
0.029280158,
-0.0059730182,
-0.008483224,
0.008336155,
-0.00003867358,
0.008931116,
0.028290782,
0.041954856,
0.009211885,
-0.01851736,
-0.015990442,
-0.0289058,
0.003130236,
0.011892557,
0.035991866,
0.035617508,
0.015522494,
-0.015281836,
-0.00043828317,
0.011076991,
-0.0050906027,
-0.019212596,
-0.01845051,
0.017233847,
0.006370774,
-0.005160795,
-0.018102892,
-0.029814955,
0.004946876,
0.006106718,
0.0050237533,
0.020108381,
0.004124625,
0.034013115,
0.009485968,
-0.00308177,
0.017100146,
-0.0015484056,
0.0037836917,
0.009713258,
-0.012467464,
-0.017648313,
0.031178689,
-0.023651415,
0.0023263686,
0.006527871,
0.004455531,
0.007594123,
-0.007420314,
-0.0021475458,
0.0032589217,
0.03329114,
-0.00234141,
-0.025910934,
0.005956306,
-0.015348685,
-0.018798128,
-0.052517105,
0.010100986,
0.01441279,
-0.0024400132,
-0.00616354,
0.0017330778,
-0.021993542,
-0.02478786,
0.0021926693,
0.014706928,
0.019921202,
0.017474504,
-0.0050839176,
0.0065846927,
0.035617508,
-0.001893517,
0.0004788108,
-0.008550073,
-0.025483096,
0.021191347,
0.00019877333,
-0.003233853,
0.017006557,
-0.014907477,
-0.016792638,
0.030429972,
-0.02474775,
0.0013369935,
0.009606298,
0.013757663,
-0.01660546,
0.028317522,
0.023277057,
-0.006858777,
-0.0030416602,
-0.0038338287,
-0.033852674,
-0.030028874,
-0.018878348,
-0.023972293,
-0.009298789,
0.0043084617,
0.0038639111,
0.0029213307,
-0.017046668,
0.0034427582,
-0.019573584,
-0.0021960118,
-0.015749784,
0.0248146,
0.025148848,
0.019760763,
0.015134767,
0.015803263,
0.014519749,
-0.00717297,
-0.005528468,
0.02465416,
0.00039295075,
-0.019533474,
-0.0019737366,
-0.0128284525,
-0.008670403,
-0.035724465,
-0.012888617,
-0.0008865938,
0.019680545,
0.0091584055,
-0.029387116,
-0.0096865175,
0.004732957,
0.01135776,
0.023357276,
-0.01664557,
-0.009626353,
-0.008376264,
0.016899597,
-0.020696659,
-0.007928371,
0.03831823,
-0.031766966,
-0.00615017,
0.038532153,
0.0057590995,
0.006400856,
-0.025937675,
-0.014238981,
-0.00028745361,
0.008189085,
-0.029654516,
-0.015134767,
0.016070662,
-0.019840984,
0.0333981,
0.029868435,
0.029119719,
-0.012881932,
0.015335315,
0.025188958,
-0.013410045,
0.002881221,
-0.009312159,
0.02842448,
-0.026325403,
0.029948654,
0.0047362996,
0.0063373493,
0.016297951,
-0.027328147,
0.011718748,
0.033665497,
-0.00820914,
-0.019881094,
0.016565349,
-0.019439885,
-0.029520817,
0.014987697,
0.004345229,
-0.001042855,
-0.036419705,
-0.001212486,
0.017741904,
0.0032572504,
0.0005147425,
0.008690458,
0.029761475,
-0.011578363,
0.019881094,
-0.01435931,
-0.012093106,
0.0066214604,
-0.008703828,
0.0064710486,
0.0064443084,
0.0037736641,
-0.010080931,
-0.009746683,
0.007981851,
0.006918941,
-0.0066983374,
-0.0036265948,
-0.0074804784,
-0.02474775,
-0.019292817,
-0.033638757,
-0.020121751,
-0.01435931,
-0.002817714,
-0.0369545,
0.0184104,
0.008804102,
-0.015602714,
0.017608205,
-0.00415805,
-0.025148848,
0.027354887,
-0.017367546,
0.02057633,
-0.0333981,
0.019533474,
0.038585633,
-0.017527984,
0.0037302119,
-0.02246149,
-0.009445859,
-0.025991153,
0.016244471,
0.033692237,
-0.039976105,
-0.01338999,
-0.0071462304,
-0.00067309267,
0.007660973,
-0.020736769,
0.0406446,
0.01639154,
0.0064108837,
-0.01824996,
-0.02266204,
-0.044281226,
-0.0006881338,
-0.007045956,
-0.008810787,
0.032061104,
-0.009191831,
-0.009058131,
0.0229027,
-0.010194575,
0.017394286,
0.011010141,
-0.011524884,
-0.004214872,
-0.012895302,
0.010448604,
0.00819577,
-0.02264867,
0.04331859,
-0.013490264,
0.022113873,
-0.0042583244,
0.032221545,
-0.0052109323,
-0.01830344,
-0.00081556605,
0.039628487,
-0.015763152,
0.00085651147,
-0.014800518,
0.00070150377,
-0.0070259008,
-0.024212953,
-0.0060699503,
-0.015803263,
-0.030857809,
-0.00830273,
0.035670985,
0.015642824,
0.004268352,
-0.0034110046,
-0.030002134,
-0.0068922015,
-0.0060565807,
-0.01118395,
-0.010655838,
-0.02673987,
0.0059596486,
0.018062782,
0.031232169,
0.013918103,
-0.000057501165,
0.013135961,
-0.017822124,
0.0006346541,
-0.0052644117,
0.022194091,
0.00020733844,
0.028558182,
-0.022274312,
0.014760409,
-0.022234201,
-0.027314777,
-0.006992476,
-0.0070192157,
-0.033906154,
0.017300695,
0.0007466273,
0.0012408971,
-0.014760409,
0.015669564,
0.025229067,
0.009786792,
0.0010111013,
0.014760409,
-0.024934929,
0.006220362,
-0.014185501,
-0.006303924,
-0.012206751,
-0.024293171,
-0.019105637,
-0.0068788314,
-0.009084871,
0.012901987,
-0.013029002,
-0.0031954146,
-0.019025417,
0.006932311,
-0.024921559,
-0.01616425,
-0.012788342,
-0.02050948,
-0.0066381725,
0.019613694,
0.00028828921,
-0.007045956,
0.0050170682,
0.0037970615,
-0.0022979577,
-0.003924076,
-0.01118395,
0.011103731,
0.010956662,
-0.020415891,
-0.02879884,
-0.0010787867,
-0.052490365,
0.01442616,
0.015789893,
0.0020923947,
-0.010234686,
0.005989731,
-0.035831425,
-0.01336325,
-0.0037235268,
0.0070927506,
0.021525595,
0.025737125,
-0.0052811243,
-0.009031391,
0.0073334095,
0.01822322,
0.0009709915,
-0.011925982,
0.018824868,
0.01643165,
0.016030552,
0.005892799,
-0.023678156,
-0.0053713713,
0.014680188,
0.011097046,
-0.002383191,
0.004188132,
-0.008376264,
-0.0203223,
-0.0041012275,
0.009893752,
0.018356921,
0.0035965126,
0.008717198,
-0.053961057,
0.007206395,
0.030135833,
0.0059329085,
-0.01337662,
-0.008603553,
0.019573584,
-0.0074336836,
-0.03334462,
-0.01441279,
-0.0012133216,
0.004248297,
-0.022327792,
0.019907834,
0.021405267,
0.0009342242,
0.023704894,
0.025897564,
-0.018196482,
-0.026900308,
-0.02061644,
-0.01442616,
-0.01434594,
-0.0060833204,
-0.00937901,
0.003793719,
-0.000804703,
0.011692008,
-0.032248285,
-0.0072531896,
-0.011658583,
0.008616923,
-0.024293171,
0.011825708,
-0.00016513959,
-0.027247928,
-0.032007623,
0.00928542,
-0.010502084,
-0.015161506,
0.013008947,
-0.01842377,
-0.03912043,
-0.018610949,
-0.007821412,
0.012012887,
0.019707285,
-0.0042315843,
-0.0066448576,
-0.015201616,
0.032622643,
0.17359523,
-0.02260856,
-0.008737252,
0.016886229,
-0.009191831,
-0.000033816534,
0.020870468,
0.0037068145,
-0.020429261,
0.012627903,
0.017180366,
0.0060833204,
0.00415805,
-0.0060164705,
0.016765898,
0.004712902,
0.006842064,
-0.004652737,
-0.0037502667,
-0.02244812,
0.0013662402,
-0.0025570001,
0.02034904,
0.011905927,
0.036018606,
-0.0107226875,
-0.03879955,
0.0070259008,
-0.010368384,
0.02053622,
-0.007353464,
0.03072411,
-0.0036533347,
0.0023397387,
-0.0071128053,
0.0062237047,
-0.007767932,
0.0011214033,
-0.0071395454,
0.0014406105,
0.023731634,
-0.02879884,
-0.0050137257,
0.014599969,
-0.0149208475,
0.011424609,
-0.0010244712,
-0.002535274,
-0.02866514,
0.020161862,
-0.045056682,
0.00359317,
0.0091650905,
0.0031670034,
0.025135478,
-0.033585276,
0.030563671,
0.025964413,
0.013249606,
0.0030633863,
-0.030082354,
0.011825708,
-0.021244826,
0.023745004,
-0.025549946,
0.015936963,
0.017113516,
-0.017634945,
0.005568578,
-0.015228356,
0.016832748,
0.010702633,
-0.016017182,
0.0015108027,
0.0006346541,
-0.0016988174,
-0.00055652356,
-0.0028127,
0.0048466013,
-0.001205801,
0.0142256105,
-0.00089662126,
-0.012520944,
0.031258907,
-0.02267541,
-0.027542066,
0.005431536,
0.024868079,
-0.021432005,
-0.00234141,
0.0076342328,
-0.021819733,
0.0150946565,
-0.009011337,
0.009238625,
-0.0016612144,
0.022047022,
0.010221316,
-0.015054546,
-0.0017715164,
-0.049655937,
0.08449799,
0.021859843,
-0.023918813,
-0.026058003,
-0.0006835379,
-0.005822607,
0.0038939936,
-0.004779752,
-0.009178461,
0.009552819,
0.0032522366,
-0.0035597451,
-0.0050003557,
0.0052710967,
0.0048265466,
0.015803263,
-0.030563671,
0.02030893,
-0.011397869,
0.0034661556,
-0.018076152,
0.014132021,
0.0042182147,
-0.0003194161,
-0.022100503,
-0.040403944,
-0.007346779,
0.00507389,
-0.027261298,
-0.010314905,
-0.013730923,
-0.010649153,
0.005284467,
-0.008670403,
0.016231101,
0.000864032,
-0.0020004765,
-0.012908672,
0.016752528,
-0.0061802524,
-0.015469015,
0.04061786,
-0.0062571294,
0.01847725,
0.018918458,
0.00051265344,
0.022969548,
-0.036286004,
-0.01633806,
-0.008082125,
-0.007801357,
-0.0023347249,
0.0026171647,
0.01870454,
-0.035751205,
-0.024079252,
-0.037676476,
-0.0056020026,
0.009178461,
-0.015709674,
0.003200428,
0.017434396,
0.0050337804,
-0.007961797,
-0.015281836,
-0.16771246,
0.0014531448,
0.012527629,
-0.022795739,
0.031980883,
0.022287682,
0.0025603424,
-0.011638529,
-0.0063373493,
0.019573584,
0.027288036,
0.014974327,
-0.037569515,
0.0057824966,
0.0015977073,
0.015388795,
0.003212127,
0.023357276,
0.027622286,
0.009038076,
0.027100857,
-0.030216053,
0.013162701,
-0.004900081,
0.0015467344,
0.004027693,
0.0019536817,
-0.00029413856,
0.017100146,
-0.024172843,
0.002398232,
-0.006822009,
0.025442986,
-0.029280158,
0.017474504,
0.01632469,
-0.012139901,
-0.012674699,
-0.0032472229,
0.025389506,
0.021432005,
0.024146102,
0.0034527858,
-0.007360149,
-0.023624675,
0.018677799,
-0.0022361216,
-0.017675053,
0.0053847414,
-0.033772457,
0.01250089,
-0.018664429,
0.026218442,
0.025041888,
0.023504345,
0.039735448,
0.02470764,
0.011972777,
-0.0065813507,
0.0029113034,
0.018677799,
0.02248823,
0.018062782,
-0.0018584209,
0.017822124,
-0.04545778,
0.012788342,
0.0042516394,
-0.02893254,
0.02478786,
-0.020001423,
0.021565706,
-0.013149331,
-0.033077218,
0.021672664,
0.01615088,
-0.0030734139,
-0.0010645811,
0.0054081385,
0.015067916,
-0.020268822,
0.023277057,
-0.019319557,
-0.017300695,
-0.017006557,
0.03270286,
0.01620436,
0.012627903,
0.027996644,
0.0005389755,
-0.009546134,
-0.045671698,
0.0020088328,
-0.0015141452,
0.025269177,
0.033050478,
0.0023648073,
-0.012962152,
-0.0037068145,
-0.02061644,
-0.0020021477,
-0.002052285,
-0.03470835,
0.0055418382,
-0.0110836765,
-0.021980174,
-0.0287721,
0.008723883,
0.0103884395,
-0.0185441,
0.024012404,
-0.0009091556,
0.016217731,
-0.005535153,
-0.0035196354,
0.004973616,
0.008657033,
-0.008964541,
-0.0020689974,
-0.0081155505,
0.05775812,
0.0048265466,
-0.01223349,
-0.008743937,
-0.0045223804,
-0.020001423,
-0.13166712,
-0.02478786,
-0.0045056683,
0.02080362,
-0.008697143,
-0.0045491206,
0.007152915,
0.026124854,
-0.02260856,
0.021151237,
-0.017073408,
-0.0034160183,
-0.012119846,
-0.013918103,
0.015335315,
-0.009980656,
-0.005769127,
-0.0063874866,
-0.012855193,
0.04313141,
-0.010843017,
-0.013543744,
-0.0055251257,
-0.011812338,
0.00228793,
0.012942097,
-0.025897564,
0.04716913,
0.01870454,
-0.0066515426,
0.018651059,
0.0045825453,
0.044201005,
0.004689505,
-0.009038076,
-0.024119362,
-0.0017848863,
-0.01660546,
0.023477606,
-0.035617508,
0.017608205,
0.015281836,
0.017314065,
-0.0054215086,
0.001900202,
-0.009399064,
-0.017019928,
0.005418166,
0.004067803,
-0.016565349,
-0.001761489,
-0.007540643,
-0.0011890886,
-0.0032672777,
0.023571195,
0.016806008,
0.008403004,
0.023972293,
-0.014252351,
-0.0019436543,
0.0027859602,
0.0138779925,
-0.001644502,
0.0116051035,
0.02871862,
-0.023678156,
0.0035697727,
-0.01639154,
0.0065880353,
-0.026953788,
-0.0040243506,
-0.010568934,
-0.009098241,
-0.021378526,
-0.043826647,
-0.013971582,
0.0066448576,
-0.0001316103,
-0.00086821016,
-0.013757663,
-0.013517004,
-0.0203223,
0.01640491,
-0.025603425,
0.030109093,
0.035911646,
0.014158761,
-0.010288165,
-0.0032990314,
-0.0059161964,
-0.0028578236,
0.029173197,
-0.003143606,
-0.012547684,
0.002694042,
0.018022673,
0.0033391411,
0.0025001778,
0.005688907,
-0.006130115,
-0.019065527,
0.0076877126,
-0.041847896,
0.018143002,
0.0031185374,
0.010455289,
0.00565214,
-0.009619668,
0.009599613,
-0.0124808345,
-0.016819378,
0.016712418,
-0.009539449,
-0.0018584209,
-0.0051307124,
0.022220831,
-0.01858421,
-0.029012758,
0.03329114,
-0.031098468,
0.023143357,
0.013102536,
0.012721493,
0.00514074,
0.0166322,
0.013075796,
-0.005037123,
0.011377814,
-0.008489909,
0.016538609,
0.000035540004,
-0.019506736,
-0.010355014,
-0.058346394,
0.014252351,
0.011745488,
0.015950331,
-0.027488586,
0.016565349,
0.018851608,
0.008650348,
0.038291495,
-0.019974682,
-0.03278308,
0.009519394,
-0.0035597451,
0.0030734139,
0.0062571294,
-0.015562604,
0.01041518,
-0.0082893595,
-0.032087844,
0.031071728,
-0.0068788314,
0.019894464,
-0.043238368,
-0.013811143,
-0.008530019,
0.017835492,
-0.0076208627,
-0.014947588,
-0.016538609,
0.019025417,
0.003101825,
0.009358955,
0.0026505897,
0.013396675,
-0.013837882,
-0.019867724,
0.011571678,
-0.003827144,
-0.019600324,
-0.019586954,
0.0077345073,
0.0152684655,
-0.0047229296,
-0.010876442,
0.022862589,
-0.007841467,
-0.011123786,
-0.009780107,
-0.0037536093,
-0.0095060235,
-0.013510319,
-0.006514501,
0.007828097,
0.029921914,
0.015816633,
-0.010528823,
0.025362767,
-0.008035331,
0.0008924432,
-0.014198871,
0.01829007,
0.0035263204,
0.022822479,
0.0032037706,
0.0052543846,
-0.005832634,
-0.008964541,
-0.0062972396,
0.006066608,
-0.0014322543,
0.009298789,
-0.016806008,
-0.03468161,
-0.009064816,
0.018811498,
-0.028531441,
-0.03508271,
-0.02453383,
0.014813888,
0.014840628,
0.031232169,
-0.009058131,
0.010328275,
-0.005906169,
0.023170097,
-0.0008932788,
-0.038104314,
0.014078542,
0.026352141,
0.00015929024,
0.021458745,
-0.012006202,
-0.013677443,
0.013657388,
-0.0014305831,
0.027996644,
-0.036794063,
0.029814955,
0.0037569518,
0.02656606,
-0.007600808,
-0.041473538,
-0.010956662,
0.009358955,
-0.02707412,
-0.012634588,
0.015402165,
0.0016244471,
0.07171633,
0.0031385922,
-0.025697015,
-0.019279446,
-0.022274312,
0.024186213,
-0.015856743,
0.0081824,
0.01028148,
-0.036179043,
0.015081286,
-0.023116618,
0.018610949,
-0.01238056,
-0.03524315,
0.0068086395,
0.0006016471,
0.010461974,
0.019974682,
-0.0075473282,
0.020268822,
-0.006811982,
0.012875248,
0.03302374,
-0.029119719,
0.01442616,
0.008509964,
0.0013219523,
0.011585048,
-0.033665497,
0.014065172,
-0.003967528,
-0.05080575,
0.0004712902,
0.0056487974,
-0.0068253516,
-0.03331788,
-0.027100857,
-0.02255508,
0.012226805,
-0.0225016,
0.005846004,
-0.017073408,
0.0033007027,
-0.01030822,
-0.0184104,
-0.012186696,
-0.013958212,
-0.02466753
] |
In bacterial translational initiation, three initiation factors (IFs 1-3) enable the selection of initiator tRNA and the start codon in the P site of the 30S ribosomal subunit. Here, we report 11 single-particle cryo-electron microscopy (cryoEM) reconstructions of the complex of bacterial 30S subunit with initiator tRNA, mRNA, and IFs 1-3, representing different steps along the initiation pathway. IF1 provides key anchoring points for IF2 and IF3, thereby enhancing their activities. IF2 positions a domain in an extended conformation appropriate for | [
-0.0114008505,
-0.03430935,
-0.033588454,
-0.027447479,
-0.016340328,
0.015018684,
-0.019344065,
0.011153876,
0.0010446329,
-0.019317366,
0.018783368,
0.014431287,
0.0037379835,
-0.00512304,
0.017635273,
-0.010873527,
0.009979081,
-0.012602345,
-0.0097654825,
0.02501779,
-0.027767878,
-0.001822267,
0.002496439,
-0.02969027,
0.0008585681,
0.028675674,
0.018342819,
-0.023883045,
-0.021092908,
-0.011587749,
-0.013817189,
-0.0153257325,
-0.02703363,
0.011734598,
-0.040156625,
-0.017328223,
0.00812344,
-0.010559804,
0.007803041,
-0.009979081,
0.048647188,
0.037166238,
-0.0012090041,
0.02985047,
-0.0055368883,
-0.0021443344,
0.0052832393,
0.008083389,
-0.019090416,
0.012261922,
-0.0074826423,
0.010619879,
-0.016820926,
0.00006982645,
-0.017501773,
-0.002489764,
-0.0067684203,
0.023068698,
-0.0027984814,
-0.0027968127,
-0.015312383,
-0.011300726,
-0.013910639,
0.016981125,
-0.0033024417,
0.022427902,
0.023602696,
0.010292805,
-0.013476766,
-0.00036795775,
0.024216793,
0.008243589,
-0.014831785,
0.0008810961,
0.035030246,
-0.02736738,
-0.010506404,
-0.005967424,
0.008417138,
-0.0036945962,
0.016967775,
-0.021079557,
0.005006228,
0.0136302905,
-0.0068952446,
-0.015352433,
0.029076172,
0.025711987,
-0.015592732,
0.005660375,
0.04130472,
0.04373441,
0.029156271,
0.027767878,
-0.007455942,
-0.0034209224,
-0.0030788302,
0.023162149,
0.0062978347,
-0.019210566,
-0.010633228,
-0.0052498644,
0.0061242855,
-0.008951136,
-0.030010669,
0.009017886,
-0.00014684936,
-0.028275177,
0.011601099,
-0.02961017,
-0.01019268,
0.030277668,
0.00516309,
-0.012041647,
0.0038481206,
0.0011581074,
0.026326085,
0.011247326,
-0.011928173,
-0.0082502635,
0.02509789,
0.02070576,
-0.010533104,
-0.028114976,
0.01618013,
-0.009271534,
-0.010593179,
0.00092364906,
0.001271582,
-0.012855994,
0.032306857,
0.02971697,
0.019477565,
0.015512632,
-0.02742078,
0.0061276234,
-0.038154133,
-0.0027334006,
0.008470538,
-0.03177286,
0.01814257,
0.025525087,
-0.015058734,
-0.011233976,
0.007522692,
0.011233976,
0.03190636,
0.0069619943,
-0.0062677977,
0.0035844592,
-0.011274026,
-0.008670787,
0.0012323664,
0.011307401,
0.014511387,
0.023923095,
-0.026366135,
0.04109112,
0.007722941,
-0.023869695,
-0.00510969,
-0.0018506356,
-0.0007359155,
-0.0057604997,
0.022347802,
0.014257737,
0.00914471,
-0.0013700378,
0.0032824168,
0.0032290171,
0.006881895,
-0.0066549457,
-0.014257737,
0.0037112837,
0.0020592285,
0.006107598,
-0.009732108,
0.006177685,
-0.019611064,
-0.010366229,
-0.00013110059,
-0.009985756,
0.032653958,
-0.004255294,
-0.030891765,
0.00572045,
-0.0064713843,
-0.029449971,
0.016580628,
-0.01258232,
-0.002294521,
0.006778433,
0.03649874,
0.007749641,
-0.63139886,
-0.026673183,
0.017835522,
-0.037406538,
-0.0039081955,
0.017488424,
-0.009712082,
-0.00448558,
-0.008430488,
0.028221777,
-0.011127177,
0.011527674,
-0.01585973,
-0.021079557,
-0.017515123,
-0.026886782,
0.0057304623,
-0.014097538,
0.022307752,
0.0019273978,
-0.012275271,
-0.021613555,
0.009725433,
0.020785859,
0.0033758665,
-0.016460478,
0.0041852067,
-0.029076172,
-0.017381623,
0.006147648,
0.0046424423,
0.02504449,
0.005783862,
-0.014618186,
0.036845837,
-0.016634027,
-0.005370014,
0.017194726,
0.031132063,
0.021493405,
-0.017808821,
-0.016527228,
0.004131807,
-0.0034342725,
-0.002139328,
0.03185296,
0.007949891,
0.013109643,
-0.009745457,
-0.009057935,
-0.009525184,
0.012348696,
-0.030357767,
0.0054334262,
0.0226415,
0.01603328,
0.018823417,
-0.004165182,
-0.004118457,
0.0017338237,
-0.01794232,
-0.0045489925,
-0.037566736,
-0.007062119,
-0.010753378,
-0.0027117068,
-0.016620677,
-0.0060608736,
0.026379485,
-0.013056243,
0.037807032,
0.02703363,
-0.020278562,
0.0046658046,
-0.020238511,
0.048700586,
0.0066649583,
0.0071755936,
0.017515123,
0.0024797516,
-0.014978634,
0.00047225418,
-0.012308646,
-0.009758807,
0.009705408,
0.002761769,
-0.023228899,
0.026793333,
-0.012789244,
-0.012248571,
-0.01838287,
-0.015699532,
-0.014871835,
-0.0114409,
-0.046804894,
0.012155122,
0.008790936,
-0.0121751465,
0.033748653,
-0.020171762,
-0.008423813,
-0.0046524545,
0.006982019,
-0.01028613,
0.026606433,
0.0050329277,
-0.028915973,
0.0113875,
0.04138482,
-0.017795471,
0.010252755,
0.0068952446,
-0.017408324,
-0.007803041,
0.0027584317,
-0.029049473,
-0.0016453803,
0.03946243,
-0.009451758,
-0.016527228,
0.00631786,
-0.0074826423,
-0.0013800502,
-0.012849319,
0.009258185,
0.03623174,
-0.0022177591,
-0.011974897,
-0.015312383,
0.015098784,
-0.00081267767,
0.01806247,
0.028889274,
-0.021613555,
0.032734055,
0.03908863,
0.019664465,
0.006074223,
-0.0083971135,
-0.035217147,
-0.03625844,
-0.03425595,
0.024483792,
-0.016487177,
-0.01132075,
-0.02471074,
-0.02963687,
0.004715867,
0.01604663,
0.006050861,
0.015539332,
0.02033196,
-0.027313981,
0.007509342,
0.009238159,
-0.016994476,
-0.033027757,
-0.048433587,
-0.014498036,
-0.0051597524,
-0.022094153,
0.009331609,
-0.01799572,
0.014658236,
-0.009057935,
-0.019410815,
0.013149693,
-0.009204784,
0.007088819,
-0.017528472,
0.017888922,
-0.0030905115,
-0.00918476,
0.028328575,
-0.03249376,
0.01580633,
0.0016420428,
0.012368721,
-0.011701223,
0.001316638,
-0.019450866,
-0.01811587,
0.0018673231,
0.000635791,
0.017808821,
0.0042185816,
0.012021623,
-0.007916516,
0.030144168,
0.027247231,
0.008817636,
-0.0049995533,
0.017915621,
0.02527144,
0.01369704,
-0.007809716,
0.0031105364,
-0.0008477213,
-0.024870941,
0.019370764,
0.020078313,
0.00112807,
0.02969027,
-0.040290125,
0.011627799,
-0.021132957,
-0.0071889437,
-0.02961017,
0.019037016,
0.004785954,
-0.0028318563,
-0.010559804,
-0.023268947,
0.0042619687,
0.012034972,
0.011334101,
0.018796718,
0.017394973,
-0.026392834,
-0.010933602,
-0.032707356,
0.0032123297,
0.032974355,
-0.00807004,
-0.018956916,
0.0033024417,
0.013189742,
-0.0007259031,
0.009425059,
0.0004305356,
-0.007375843,
0.007836415,
0.012508895,
0.02734068,
-0.0035510845,
0.005890662,
-0.0066783084,
0.007756316,
0.031025264,
-0.013062918,
-0.007489317,
0.018796718,
-0.011420875,
-0.017795471,
0.009331609,
-0.0056436877,
0.028675674,
0.015245633,
-0.015138834,
0.03676574,
-0.011093802,
0.009071285,
-0.019557664,
-0.009284885,
-0.023228899,
0.013990738,
0.008216889,
0.0078631155,
0.026806682,
0.028408676,
0.013476766,
-0.0024547204,
0.012008272,
-0.0017955671,
0.0113407755,
0.00056904124,
-0.021787105,
-0.006995369,
-0.016153429,
-0.0038948455,
-0.039168727,
0.0068752198,
0.0056637125,
0.00914471,
0.0059240367,
-0.015258983,
0.011814699,
0.029770369,
-0.019344065,
-0.017314874,
-0.017274825,
-0.014618186,
0.032413658,
0.008704162,
-0.012588995,
-0.0048927534,
-0.021119608,
-0.0018372857,
-0.0076828916,
0.006684983,
-0.018089171,
-0.0012891038,
-0.0032590544,
0.010432979,
0.0017421674,
-0.007569417,
0.024216793,
-0.02070576,
0.027794579,
0.016740827,
0.015005334,
-0.010366229,
-0.010206031,
-0.0037947209,
0.06589531,
-0.010039156,
0.004508943,
0.011274026,
0.010920252,
0.009558558,
-0.008090065,
0.0071755936,
-0.010613203,
0.0015928149,
0.0055602505,
-0.004161844,
-0.0025381576,
-0.011420875,
0.022027403,
0.003035443,
0.0021476718,
-0.01256897,
0.008470538,
0.012388745,
0.012462171,
0.04282661,
0.025685288,
0.030731566,
0.011067102,
0.006588196,
0.012014947,
-0.040850822,
0.010553129,
-0.013236467,
-0.006881895,
-0.0044588805,
0.038394433,
-0.004876066,
0.011314075,
0.018596468,
-0.0057671745,
-0.030464567,
0.014257737,
0.0019474227,
0.02529814,
0.003948245,
-0.00062410976,
0.027634379,
0.0062644603,
-0.009752132,
0.017648622,
0.016367028,
0.0096186325,
-0.021306507,
0.0029369872,
0.022387851,
0.0006641596,
0.00081059174,
0.009892306,
-0.025711987,
0.003934895,
0.017728722,
0.0023596021,
0.017141325,
0.0009119679,
0.01593983,
0.0058072247,
0.0046858294,
0.007849766,
-0.0005373352,
-0.015846381,
-0.002146003,
-0.004145157,
-0.026059086,
0.03163936,
-0.00011337021,
-0.009858931,
-0.028809173,
-0.000097308555,
-0.002329565,
-0.024750791,
0.0029803745,
0.008430488,
-0.041571718,
-0.017114624,
-0.029877169,
0.025391588,
0.00789649,
-0.016874326,
-0.005460126,
0.0010863515,
-0.0052965893,
-0.01368369,
-0.0085773375,
-0.009999107,
-0.01587308,
-0.035724442,
-0.014724986,
0.0046157422,
0.033187956,
-0.0022845087,
0.0052832393,
0.01611338,
0.021640256,
-0.018956916,
0.00014653646,
0.011921498,
-0.022935199,
-0.017394973,
0.027981477,
0.012014947,
-0.02529814,
-0.020799208,
-0.015712881,
0.016553927,
0.01838287,
-0.00075343734,
-0.020679059,
-0.006881895,
0.031292263,
0.01369704,
0.010693303,
-0.0053099394,
-0.026699884,
0.007742966,
-0.032653958,
-0.012722494,
-0.035537545,
-0.0043620933,
-0.014484687,
-0.0069753444,
-0.0003733812,
-0.00201751,
0.00058447715,
-0.0054234136,
-0.016286928,
0.021666955,
0.011274026,
0.023402447,
0.023669446,
0.013122993,
0.0058472743,
0.0018906854,
-0.014417937,
-0.0094984835,
-0.018836768,
0.042906713,
0.0024196769,
-0.008430488,
0.032787457,
-0.0074692923,
-0.02517799,
-0.020278562,
-0.0010955295,
-0.024109995,
0.043894608,
0.018956916,
-0.030010669,
-0.01830277,
-0.01573958,
-0.034763247,
0.019344065,
-0.025978986,
-0.026806682,
-0.010473029,
-0.010092556,
-0.004241944,
-0.017581873,
-0.0002651215,
-0.023669446,
-0.0039849575,
0.011033727,
-0.008710837,
0.02046546,
-0.016447129,
0.0019240603,
-0.030758265,
-0.02033196,
-0.008337039,
-0.03409575,
0.009945706,
-0.03238696,
0.046377696,
0.019063717,
0.03209326,
0.0031839611,
0.003404235,
0.033374853,
0.0073958677,
0.008537288,
0.00807004,
0.015352433,
-0.03195976,
0.022107502,
0.016326979,
-0.00114142,
0.009011211,
-0.031292263,
0.014498036,
0.022267703,
-0.03396225,
-0.0108067775,
-0.0027417443,
-0.024870941,
-0.02723388,
-0.0011355794,
-0.00902456,
-0.004695842,
-0.03441615,
-0.00903791,
-0.0137504395,
-0.018743318,
0.019277316,
-0.00512304,
0.031185463,
-0.012822619,
0.037219636,
-0.006201048,
0.009298234,
-0.0034075726,
-0.007823066,
-0.014271087,
0.01614008,
0.017848872,
0.01787557,
-0.0014217688,
0.00089194294,
-0.0074025425,
0.00342426,
0.014471336,
-0.013343266,
0.0005657038,
-0.015085434,
-0.002075916,
-0.000651644,
-0.046003897,
-0.030891765,
-0.036819138,
0.013817189,
0.011327425,
0.0046658046,
0.013937339,
-0.008664112,
-0.016660728,
0.060501933,
-0.01031283,
0.035484146,
0.008090065,
0.011160551,
0.020024912,
0.008810962,
-0.014751686,
-0.023682795,
-0.010239406,
0.017982371,
0.019597715,
0.04296011,
0.0025832136,
-0.0038381082,
-0.0026115824,
0.0012390414,
-0.008737537,
-0.037620135,
0.03193306,
0.0026099135,
0.014484687,
-0.005830587,
0.004408818,
0.011914823,
0.010713328,
-0.0058405995,
0.021186357,
0.0058405995,
-0.0012006604,
-0.018089171,
0.0036144967,
-0.010946952,
0.0034743224,
-0.011220626,
-0.0018506356,
0.013496791,
-0.04098432,
-0.011641149,
0.011761298,
-0.007289068,
0.015432532,
0.001339166,
0.008410463,
-0.020612309,
0.02942327,
-0.011781324,
-0.014711635,
-0.0064246594,
0.035003547,
-0.009772157,
-0.012956118,
0.008670787,
0.02082591,
0.0025648575,
-0.011020376,
0.0046424423,
0.0044021434,
-0.023575997,
-0.0016845957,
0.016901026,
-0.0015719556,
-0.008497238,
-0.011921498,
-0.019624414,
0.01596653,
-0.0013057912,
0.011774648,
0.026980232,
-0.039142027,
0.0019173854,
0.009698733,
0.05198467,
0.025778737,
0.023522597,
0.014684936,
0.007582767,
0.033641852,
-0.019117117,
0.0036044843,
0.021426655,
-0.005947399,
-0.008357063,
-0.000017978095,
-0.022040753,
-0.02082591,
0.0026149198,
-0.008757561,
-0.0069686696,
0.011914823,
-0.0039015205,
0.032520458,
0.008150139,
-0.015726231,
0.0144045865,
0.013122993,
-0.006097586,
-0.013062918,
-0.0060341735,
0.011641149,
-0.007362493,
0.012308646,
0.032413658,
-0.00042135752,
0.015232284,
0.00690192,
-0.0029536746,
0.0049428158,
-0.013843889,
-0.0065748463,
-0.0014876841,
0.00257487,
-0.0137504395,
-0.005837262,
0.019757913,
-0.019918112,
-0.009551883,
0.0078631155,
0.0066516083,
0.0016095024,
-0.025057841,
0.004345406,
0.010012456,
0.0062744725,
-0.0028802499,
-0.012315321,
0.025605189,
-0.010860178,
-0.023001948,
0.012061672,
-0.019010317,
0.033535052,
-0.012942769,
-0.021560155,
-0.00911801,
-0.015352433,
-0.046671394,
0.0006295332,
0.0027217192,
-0.008210214,
0.016887676,
-0.026245985,
-0.009972407,
0.013910639,
-0.008957811,
0.009191435,
-0.0012106728,
-0.01021938,
0.028408676,
0.010179331,
0.012936093,
0.013296542,
-0.039008528,
-0.007769666,
0.035430744,
-0.0020225162,
-0.015566031,
0.039862927,
-0.015272333,
-0.0120549975,
0.00014121734,
-0.010886877,
0.01032618,
0.01839622,
0.02043876,
-0.014124238,
-0.027073681,
0.01593983,
0.006591534,
-0.01588643,
-0.0060007987,
-0.0065982086,
0.015579382,
-0.019557664,
0.0024013207,
-0.0031989797,
0.013036218,
-0.0015761275,
0.022134203,
0.02961017,
0.016473828,
-0.0004543152,
0.02509789,
-0.0037313087,
-0.017221425,
0.0069352947,
-0.021026159,
-0.017461723,
0.01607333,
0.008183514,
-0.009451758,
-0.0046925046,
-0.02511124,
0.004221919,
-0.012068347,
-0.00203086,
-0.0036779088,
-0.013236467,
0.0029319809,
0.003190636,
-0.01383054,
-0.0062077227,
0.0071689184,
-0.026272684,
-0.03396225,
-0.0065648337,
-0.005336639,
-0.016473828,
0.01624688,
-0.0044021434,
-0.01145425,
0.011274026,
0.0061376356,
0.021813804,
-0.022414552,
0.028088277,
0.2030259,
-0.021546805,
-0.004662467,
0.027874678,
-0.0069886944,
-0.0074225673,
0.017915621,
-0.0050763153,
-0.0045556678,
0.0014634873,
0.024230143,
0.02716713,
-0.03414915,
0.001997485,
0.01607333,
-0.008050014,
-0.022775,
-0.008957811,
-0.033855453,
0.018462969,
-0.002172703,
-0.015499282,
-0.00010075034,
0.007762991,
0.010900227,
0.0016503865,
-0.016220178,
0.0075961165,
0.01260902,
0.005326627,
-0.016500527,
-0.011420875,
0.0012640726,
0.0111939255,
0.0018122545,
-0.005920699,
-0.010266105,
-0.00035877968,
-0.0023979833,
-0.0002586551,
-0.02039871,
0.014524736,
-0.0078631155,
-0.02508454,
0.007716266,
-0.007455942,
-0.021813804,
-0.005259877,
0.0029937243,
0.017007826,
-0.029022774,
-0.01607333,
0.00512304,
0.016727477,
-0.0072423434,
-0.02270825,
0.013910639,
0.020305261,
0.0071488936,
-0.016941076,
-0.0121150715,
0.017127976,
-0.042933412,
-0.019344065,
-0.026432885,
0.03185296,
-0.027006932,
0.018529719,
0.00041802003,
-0.049448185,
0.00028618937,
0.008363739,
-0.032734055,
0.012902718,
-0.033187956,
-0.011087126,
0.03182626,
0.012014947,
0.047285493,
0.037486635,
-0.009872282,
-0.014845135,
-0.019477565,
0.006511434,
0.0046290923,
-0.025311489,
0.031105364,
-0.005570263,
-0.019103765,
-0.0063078473,
0.0051731025,
-0.024643991,
-0.00039090298,
-0.003624509,
0.008570663,
-0.010332854,
-0.026779983,
-0.0022077465,
-0.006244435,
-0.015085434,
-0.017154675,
0.062851526,
-0.0031872985,
-0.005763837,
-0.028675674,
0.02055891,
-0.00906461,
-0.010032481,
-0.0012256915,
-0.0011981572,
0.017288174,
-0.004979528,
0.014351187,
0.0065781837,
-0.0010946952,
0.008690812,
0.018409569,
-0.03481665,
0.038047332,
-0.01260902,
-0.013590241,
-0.010653254,
0.0049528284,
0.012335346,
0.0013349941,
-0.008470538,
-0.016353678,
0.00006362081,
0.0041718567,
-0.030357767,
0.011674524,
0.012835968,
-0.00008369787,
0.0003055885,
-0.0066449335,
0.00899786,
0.006341222,
0.005777187,
-0.008457188,
0.017408324,
-0.020145062,
0.00913136,
-0.013323242,
-0.0039782827,
-0.010085881,
-0.019330716,
0.007929865,
0.003721296,
-0.027767878,
0.008337039,
0.0016946082,
-0.0058839866,
0.0021693655,
-0.007549392,
0.025685288,
-0.0066916584,
-0.008390438,
-0.02928977,
-0.008824311,
0.023188848,
-0.019384116,
-0.0036378591,
0.024096644,
-0.026165886,
0.012982818,
0.00042010596,
-0.16852966,
0.01016598,
-0.010266105,
-0.015472583,
0.068244904,
0.014084188,
0.008851011,
0.0115744,
-0.0010930265,
-0.020732459,
0.020105012,
-0.003125555,
-0.036685638,
-0.02046546,
-0.012575645,
0.015592732,
-0.021787105,
0.022935199,
0.028996073,
-0.0061176107,
0.033401553,
-0.042052317,
0.0024397017,
-0.00019159252,
-0.004165182,
0.020278562,
-0.0052365144,
-0.02495104,
0.00071755936,
-0.010893553,
-0.031078665,
0.0055669257,
0.037593435,
-0.038367733,
0.03158596,
-0.008710837,
-0.005994124,
0.0061276234,
0.006130961,
0.019130467,
0.015192233,
0.011767973,
-0.0008068371,
-0.003514372,
-0.011641149,
0.0018790043,
0.012101722,
0.00025510904,
0.022734951,
-0.010199355,
-0.006621571,
-0.017007826,
0.015138834,
0.0051597524,
0.017194726,
-0.0025448326,
-0.002858556,
0.0065414715,
-0.0018105858,
-0.01800907,
0.001997485,
0.015485932,
0.049875382,
-0.015018684,
-0.0058839866,
-0.023696147,
-0.012048322,
0.021600205,
-0.024991091,
0.0055302135,
-0.0029286435,
-0.02942327,
-0.013623616,
-0.02045211,
0.012135097,
0.014391237,
-0.014351187,
0.022427902,
-0.0012373728,
0.005329964,
-0.010306154,
0.028675674,
-0.0001107628,
-0.006017486,
-0.008083389,
-0.00798994,
-0.004395468,
0.013857239,
-0.015339083,
-0.019477565,
0.017688673,
-0.023829646,
-0.0066783084,
0.0017555173,
0.017087925,
0.02509789,
-0.007823066,
-0.016273579,
-0.0055268756,
-0.0047225417,
0.0059040114,
-0.0026716571,
-0.0146715855,
0.025845487,
0.01599323,
0.0037880458,
-0.003269067,
-0.00082269014,
0.053239565,
-0.0066649583,
-0.013089618,
-0.0006349566,
0.009945706,
0.03393555,
-0.011160551,
0.012195172,
-0.020879308,
0.0034643097,
-0.021266457,
-0.020478811,
0.058098946,
-0.003921545,
-0.00621106,
-0.005974099,
-0.018770019,
-0.0230153,
-0.12591664,
0.006247773,
0.004001645,
0.01368369,
0.0013441723,
0.008543963,
0.00056862406,
0.012508895,
-0.014858485,
0.016660728,
-0.01827607,
-0.012208521,
0.0061977105,
-0.013176392,
0.0047892914,
0.015485932,
0.035537545,
-0.024617292,
-0.02278835,
0.032920957,
-0.01132075,
0.012655744,
0.0017471736,
-0.008944461,
0.0019924787,
-0.016941076,
-0.02527144,
0.01814257,
0.0038748204,
0.013296542,
0.0022795026,
-0.019090416,
0.024083294,
-0.008063365,
-0.0069686696,
0.00809674,
-0.008503913,
-0.028942673,
0.02491099,
0.0005185618,
0.00691527,
-0.006174348,
-0.00055151945,
-0.0062611224,
0.01032618,
-0.0071288687,
-0.0011355794,
0.006788445,
-0.0060608736,
-0.0012640726,
-0.02958347,
-0.035270546,
-0.041625116,
-0.017261473,
0.0030905115,
0.009211459,
0.010172656,
0.018903516,
0.0033241354,
-0.008931111,
-0.0011155545,
-0.011334101,
-0.027060332,
0.016273579,
0.007876465,
-0.019010317,
0.005967424,
-0.02503114,
0.015112134,
-0.031132063,
-0.0016011586,
0.0046391045,
-0.004695842,
0.019050367,
-0.023842996,
-0.013236467,
-0.03922213,
-0.032974355,
0.014030788,
-0.009758807,
-0.012068347,
-0.037379835,
0.021720355,
-0.02508454,
0.018649869,
0.012335346,
0.013430041,
-0.019611064,
0.023629397,
-0.019984862,
0.009625308,
0.033721954,
0.01611338,
-0.015472583,
-0.011053751,
0.026900131,
-0.018462969,
-0.0013892283,
0.0049061035,
0.0037913835,
-0.015539332,
-0.0031555924,
-0.06632251,
0.024069944,
-0.009732108,
-0.024150044,
0.00396827,
-0.0040049823,
0.0025581825,
-0.0051030153,
0.022387851,
0.037246335,
-0.005583613,
0.0023462523,
-0.008817636,
-0.008724187,
-0.018823417,
0.009044586,
0.035030246,
-0.0023395773,
0.021079557,
0.0113407755,
-0.02928977,
-0.00019983193,
0.010519754,
0.05030258,
-0.011233976,
-0.0007692904,
-0.017194726,
0.017728722,
-0.016674077,
-0.0011848073,
-0.011334101,
-0.019597715,
-0.0059373863,
0.023135448,
-0.01029948,
-0.01580633,
-0.011500974,
0.035671044,
0.029102873,
0.037566736,
-0.0022778339,
-0.044482004,
0.03906193,
-0.0056570377,
0.0011430888,
-0.0011848073,
-0.027741179,
-0.0008810961,
0.0050896653,
-0.024991091,
0.014644885,
-0.011334101,
-0.0047125295,
-0.0057004252,
-0.015192233,
0.02722053,
-0.0074826423,
0.0026699882,
-0.0021943967,
-0.016820926,
0.017047875,
0.021506757,
0.0029353183,
0.014498036,
0.02075916,
0.00100208,
-0.037887134,
-0.016153429,
0.0035043596,
-0.039836224,
-0.037433237,
-0.006037511,
-0.005576938,
0.012835968,
0.004091757,
0.0124421455,
-0.02278835,
0.011828048,
-0.0005410898,
0.023175498,
0.015646132,
-0.0010955295,
-0.016887676,
0.006531459,
0.019477565,
0.003015418,
0.01631363,
0.034522947,
-0.01863652,
-0.012321996,
-0.013149693,
0.012735845,
0.005927374,
0.00406172,
0.035030246,
0.03211996,
-0.007856441,
-0.0021259782,
0.023549296,
-0.008757561,
-0.009291559,
-0.014511387,
0.008690812,
-0.012188497,
-0.0066249087,
0.015352433,
-0.039996427,
-0.046965092,
-0.02504449,
-0.006775095,
-0.030331068,
-0.003878158,
0.008617387,
0.01373709,
-0.014511387,
0.0050429404,
-0.009591933,
-0.009905657,
0.00342426,
0.0050095655,
0.013883939,
0.051343873,
-0.021947304,
-0.00025406608,
0.0049061035,
0.025444988,
0.022614801,
-0.014484687,
0.012642395,
0.0032874232,
0.024163393,
0.011093802,
-0.002761769,
-0.021560155,
0.00101543,
-0.003067149,
0.008570663,
-0.00691527,
0.011367476,
0.08704162,
0.024590593,
0.0025982324,
0.007516017,
-0.008857686,
0.015339083,
0.009778832,
-0.00688857,
0.010699978,
-0.030411167,
0.02523139,
-0.006855195,
-0.009812207,
-0.01814257,
-0.011527674,
0.0070020445,
-0.009585258,
0.024176745,
-0.026699884,
-0.028915973,
0.02062566,
-0.014524736,
0.01614008,
0.008984511,
-0.030945165,
-0.0026816695,
0.019397466,
-0.0052965893,
0.009324934,
-0.046003897,
0.00037984757,
-0.013383317,
-0.028248476,
-0.008624062,
0.026179235,
-0.009585258,
-0.004145157,
0.00062452693,
0.015365783,
0.026072435,
0.003721296,
-0.021493405,
-0.0002240287,
-0.023562647,
0.010606528,
0.028835874,
-0.003404235,
0.0114609245,
-0.025685288
] |
In higher eukaryotes, introns are spliced out of protein-coding mRNAs by the spliceosome, a massive complex comprising five non-coding RNAs (ncRNAs) and about 200 proteins. By comparing the differences between spliceosomal proteins from many basal eukaryotic lineages, it is possible to infer properties of the splicing system in the last common ancestor of extant eukaryotes, the eukaryotic ancestor. We begin with the hypothesis that, similar to intron length (that appears to have increased in multicellular eukaryotes), the spliceosome has increased in complexity | [
-0.017947348,
-0.009286322,
-0.007151,
-0.009592318,
-0.014980514,
0.007157652,
0.0010044661,
-0.008567896,
-0.024160402,
0.008940413,
0.011933855,
-0.0000192417,
-0.0010227594,
-0.009306278,
0.0168431,
0.02485222,
0.029189384,
0.016324237,
0.0032428955,
-0.0031397878,
-0.01290506,
0.021113744,
-0.017055966,
-0.022497378,
0.020395318,
0.025796818,
-0.01560581,
-0.029535294,
-0.006229685,
-0.039806124,
-0.004866006,
-0.00398793,
-0.028391134,
-0.032116305,
-0.029136168,
0.00041430068,
0.013823049,
-0.008561243,
-0.013796441,
0.00743704,
0.0340055,
0.022111557,
-0.017268833,
0.0119870715,
0.0066653974,
-0.006442552,
-0.0141157415,
-0.0047495943,
-0.010350657,
0.009984791,
0.018173518,
0.0040910374,
-0.012100157,
-0.0073372587,
-0.018359777,
-0.010277484,
-0.016350845,
0.0021752345,
0.008621112,
-0.010430482,
0.0105635235,
-0.0054247817,
-0.01585859,
0.026049597,
-0.017122487,
0.031770397,
0.01242611,
-0.013650095,
0.0012422784,
-0.008680982,
0.029322427,
0.017228922,
-0.022537291,
0.015047034,
0.016151281,
-0.036586512,
-0.009924923,
-0.00008538585,
-0.0047296383,
0.0064059654,
0.0016164586,
-0.018013868,
-0.0018875314,
-0.0008897174,
0.026608372,
-0.006013492,
0.017029358,
0.014661213,
-0.0029086277,
0.013337446,
0.025583949,
0.03820962,
0.013783136,
0.034697317,
-0.015432856,
-0.026368897,
-0.016297627,
0.029003127,
-0.0030167243,
-0.03153092,
-0.016071457,
0.008268552,
-0.019650282,
-0.009805185,
-0.015592506,
0.009472581,
0.008541288,
-0.022670332,
0.012226547,
-0.0006040932,
0.008873892,
0.033020988,
-0.017375266,
-0.02450631,
0.034298193,
-0.0133108385,
0.03256865,
-0.017348658,
-0.0030599628,
0.00842155,
0.010610089,
0.0011125626,
0.0024213619,
-0.047708813,
0.038369272,
0.02240425,
0.009612274,
0.012878452,
0.0034657405,
-0.0052817618,
0.030918928,
-0.0069181765,
-0.0036054344,
0.027326798,
-0.011554685,
-0.012885104,
-0.010191007,
-0.012026984,
0.008035729,
-0.041296195,
0.02730019,
0.013370707,
-0.01732205,
-0.006628811,
0.00784947,
0.0028437697,
0.028045224,
0.012944973,
0.01013779,
0.021619303,
0.009485885,
0.01049035,
0.011102343,
-0.02908295,
0.014900688,
0.02663498,
-0.0033958936,
0.012412806,
-0.016577017,
-0.0026658264,
-0.013038103,
-0.01261902,
0.015379639,
0.0025893273,
0.008960369,
0.01881212,
-0.0024546224,
0.008175422,
0.0034557623,
-0.008448158,
-0.027007498,
0.0030616259,
-0.039992385,
0.024679266,
-0.019942975,
-0.0073039983,
-0.0022999612,
0.029295817,
-0.03139788,
-0.026834544,
-0.0034790447,
0.002135322,
0.02730019,
-0.0012298058,
-0.0009487548,
-0.009273018,
0.02517152,
-0.011807465,
0.02974816,
-0.0011740944,
-0.013676703,
-0.0072640856,
-0.01045709,
-0.0055445195,
-0.6351951,
-0.028231483,
0.02443979,
-0.026435418,
0.018053781,
0.02368145,
0.0016871371,
-0.0018675751,
-0.007836166,
0.01910481,
-0.042892694,
0.039140914,
0.026422113,
-0.031025361,
-0.03613417,
-0.034936793,
-0.0063860095,
-0.01830656,
0.028178265,
-0.011341819,
-0.016098065,
-0.013556966,
-0.00069223344,
0.0070312624,
0.0024562853,
0.002346526,
0.018106997,
-0.021313306,
-0.013809745,
0.022164773,
-0.021180265,
0.006924829,
-0.02688776,
-0.0000042160236,
0.043211997,
-0.0070312624,
-0.0051919585,
0.0126921935,
0.016164586,
0.024147097,
-0.0068316995,
-0.007842817,
0.022430858,
0.008068989,
-0.016976142,
0.005301718,
0.021499565,
-0.0061132736,
0.010403873,
-0.03762424,
-0.004722986,
0.011780857,
-0.022510683,
-0.0069115246,
-0.042307314,
0.011880638,
0.021153657,
-0.003565522,
0.01487408,
0.0021020614,
-0.016643537,
0.015047034,
-0.023269022,
-0.0098584015,
-0.015871894,
-0.018479515,
-0.02322911,
-0.0047495943,
0.006938133,
0.005082199,
0.028337916,
0.019969583,
-0.010151094,
-0.02233773,
-0.020262275,
0.032967772,
0.011115648,
-0.0053349785,
-0.005028982,
0.030972145,
-0.007077827,
-0.023974143,
-0.029508684,
-0.013616835,
0.016377453,
-0.0013287556,
-0.017694568,
0.020288885,
0.022896504,
-0.0016713383,
0.0012306372,
-0.004227405,
-0.009066802,
-0.030014243,
-0.038422488,
-0.0033326987,
0.0057839947,
-0.008188726,
0.015140164,
-0.0174817,
-0.007809557,
-0.008175422,
0.009000282,
-0.017495004,
0.010882825,
-0.0090534985,
-0.023069458,
0.0041043414,
0.01627102,
-0.015086947,
0.016098065,
-0.022563899,
0.010723174,
0.0007658222,
-0.021672519,
-0.01601824,
0.009233105,
0.012705497,
0.015326423,
-0.03922074,
-0.009359495,
0.0038183015,
-0.0030233762,
-0.006891568,
0.0081621185,
0.01929107,
0.0006386009,
-0.055345412,
-0.0046232045,
-0.013423923,
0.0006489948,
-0.023149284,
0.029561901,
-0.01665684,
0.011188821,
0.028391134,
0.028604,
0.0015083621,
0.010470394,
-0.030306935,
-0.004150906,
-0.0059835576,
-0.0174817,
-0.020475142,
-0.0068383515,
-0.027246973,
-0.04430294,
-0.0023648192,
0.01789413,
0.016058153,
0.015459464,
0.0070711747,
-0.0026758043,
0.002437992,
-0.010669957,
-0.0058571678,
-0.015818678,
-0.037890323,
-0.032488823,
-0.02110044,
-0.0013013157,
0.03038676,
-0.012007028,
0.022284511,
0.00091133674,
-0.011448252,
0.009765273,
0.00050181727,
0.01344388,
-0.018705687,
0.018838728,
0.00816877,
0.00090385316,
0.0019923018,
0.005019004,
0.015619114,
0.001214007,
0.013862962,
0.0263822,
-0.011069083,
0.001503373,
-0.011328515,
-0.01061674,
-0.028870083,
0.01299819,
0.021619303,
0.046484828,
-0.006073361,
0.015339727,
0.010244223,
-0.0018293256,
0.008847284,
-0.004709682,
0.024493007,
0.0033842523,
-0.014847471,
0.010290788,
0.0046065743,
-0.003645347,
0.018240038,
0.022018429,
-0.0096721435,
-0.014754342,
-0.011335166,
0.010077921,
-0.02091418,
0.004224079,
-0.0102043105,
0.015379639,
0.011308558,
-0.01640406,
0.00042032913,
-0.0045467056,
-0.010889476,
0.016962837,
0.021845473,
-0.015632419,
0.0026275767,
0.0014701126,
0.002644207,
-0.004204123,
-0.014847471,
0.013483793,
0.006379357,
-0.02180556,
0.006425922,
-0.020448534,
0.041269585,
-0.004117646,
-0.030626236,
0.014315304,
0.027060714,
-0.0007425399,
0.004563336,
0.03038676,
0.025264649,
0.013277578,
-0.011188821,
0.038502313,
0.0070977835,
-0.014993818,
0.0030200502,
-0.0054148035,
-0.012645629,
0.02523804,
-0.007217521,
0.033420116,
0.027180452,
-0.0013270925,
0.0098584015,
0.009559058,
-0.005724126,
-0.012346284,
-0.014395129,
0.012213243,
-0.028098442,
-0.0015524322,
0.0200228,
0.05316353,
0.0254243,
-0.008927109,
-0.021659214,
0.001321272,
-0.001357027,
-0.00085313094,
0.0018326517,
0.0075434735,
-0.009100064,
0.0027456514,
-0.0060401005,
-0.035096444,
-0.0120735485,
-0.015060338,
-0.005820581,
0.01773448,
0.013769832,
0.00927967,
0.02730019,
-0.0014410097,
-0.0033726112,
-0.04297252,
-0.01808039,
0.0352827,
0.017122487,
-0.020368708,
-0.012439414,
-0.05377552,
0.011774205,
-0.01643067,
0.03530931,
-0.01773448,
0.010836259,
-0.0026691523,
0.013942787,
0.002993442,
-0.0033393507,
0.028284699,
-0.02942886,
0.026768023,
-0.009971487,
0.003502327,
-0.01242611,
-0.008368333,
0.014395129,
0.07365198,
-0.01455478,
0.005268458,
-0.0043271864,
0.003153092,
-0.021539478,
-0.021446347,
-0.035229485,
0.011301906,
0.0060234703,
-0.009339538,
-0.015565897,
-0.0021669194,
0.0059436453,
0.009093411,
0.0151667725,
-0.008049033,
-0.027167149,
-0.010889476,
0.00041783458,
0.022617117,
0.035389137,
-0.01360353,
0.033020988,
0.0034191757,
-0.0022849939,
-0.019823236,
-0.010676609,
0.020288885,
-0.02581012,
-0.013277578,
0.0023049503,
-0.0011657793,
0.00079575664,
0.015512681,
0.02148626,
0.021313306,
-0.02656846,
-0.012991537,
-0.014900688,
0.022284511,
0.0028604,
0.0053150225,
0.026807934,
0.008082293,
-0.009266365,
-0.016789883,
0.023601627,
0.014368521,
-0.006223033,
0.0070711747,
0.01931768,
0.01090278,
0.0006485791,
-0.014155654,
-0.006076687,
0.014155654,
0.008554592,
0.010603436,
0.0024712526,
0.027672706,
0.032595254,
0.016723363,
-0.0017079249,
-0.009459277,
-0.0045267493,
-0.018492818,
0.031318054,
0.0027839008,
-0.0061066216,
0.0134970965,
-0.0031048644,
0.0073039983,
-0.010942693,
0.0030000939,
-0.0206614,
-0.016457278,
0.0056143664,
-0.011720988,
-0.015206684,
-0.01306471,
-0.02714054,
0.0076765153,
-0.0067552007,
0.011561338,
-0.0115413815,
0.014980514,
0.012319677,
-0.020581575,
-0.012033637,
0.00686496,
-0.042892694,
-0.03283473,
-0.0075833863,
0.01706927,
0.029349035,
0.014275392,
-0.031584136,
0.016510494,
0.017135791,
-0.0063993135,
-0.0057474086,
0.02459944,
-0.029482076,
0.0102176145,
-0.0043039043,
-0.023242414,
-0.025796818,
0.0038482358,
-0.0343248,
0.007995816,
-0.013703312,
0.0025810122,
0.0033160683,
0.0097719245,
0.01789413,
0.017109184,
0.047176644,
0.013796441,
-0.0018093693,
0.00343248,
-0.013543662,
-0.0090534985,
-0.03166396,
-0.012060245,
-0.011880638,
-0.00018636255,
0.007377171,
0.014222175,
-0.007483605,
0.026555156,
-0.008175422,
0.011521425,
0.022590509,
0.013171144,
0.024745787,
-0.009352843,
0.02412049,
-0.012825236,
-0.0077031236,
-0.005774017,
-0.0013013157,
0.022710245,
0.0071776086,
-0.0070246104,
0.023947535,
-0.011301906,
0.0020355405,
-0.0038382576,
0.012346284,
-0.0070246104,
0.03757102,
0.030173894,
-0.035974517,
0.017747784,
-0.016457278,
-0.014421738,
0.0030233762,
-0.0069181765,
-0.00066978263,
0.0032661776,
0.012532543,
-0.030865712,
0.010516959,
-0.009326234,
-0.033127423,
-0.0027805748,
0.02173904,
0.014435042,
0.010862868,
-0.01229972,
-0.015672332,
-0.031504314,
-0.009652187,
0.0059037325,
-0.028737042,
-0.009120019,
-0.014860776,
0.06167821,
0.031131795,
0.02310937,
-0.023388758,
0.0096721435,
0.026169334,
0.025504125,
-0.01058348,
0.0037451284,
0.0041143196,
-0.0012688867,
0.01935759,
0.021313306,
-0.0004768719,
0.0045600096,
-0.02247077,
0.002650859,
0.024226923,
-0.021499565,
-0.003931387,
0.013676703,
-0.034856968,
-0.037038855,
-0.00398793,
-0.007377171,
-0.0071177394,
-0.010982606,
-0.003781715,
-0.009193192,
0.0141157415,
0.016497191,
-0.0200228,
0.028045224,
-0.008408246,
0.0074104317,
-0.013364055,
0.01077639,
-0.017175704,
0.018093692,
-0.02205834,
0.0074170837,
0.01115556,
-0.010882825,
0.010038008,
0.0031963307,
-0.009146628,
0.0037052159,
-0.006099969,
-0.03530931,
0.008780763,
0.016204499,
-0.0020305514,
0.00016879686,
-0.03121162,
-0.012831887,
-0.034777142,
0.002351515,
0.016031545,
-0.00070345885,
0.010370613,
-0.012452718,
-0.032329172,
0.040897068,
0.0017295441,
0.023335543,
-0.0039712996,
0.019783325,
0.018891944,
-0.016204499,
-0.02425353,
-0.03581487,
-0.0034790447,
-0.0025244693,
0.026209246,
0.023016242,
-0.00997814,
-0.0048793103,
0.0024812308,
-0.015419552,
-0.009026891,
-0.040258467,
0.015392943,
-0.011401688,
0.017361963,
-0.0047695506,
0.015725547,
0.018359777,
0.016776579,
0.002082105,
0.006013492,
-0.0031663962,
-0.009452624,
-0.006565616,
0.01315784,
0.003801671,
0.020315493,
-0.0153530305,
-0.034564275,
-0.004732964,
-0.022843288,
0.017973956,
0.001249762,
-0.0034058716,
0.043078955,
-0.0035189572,
-0.012525891,
0.013849658,
0.01258576,
-0.011122299,
-0.015645722,
-0.00264587,
0.03927396,
-0.020262275,
0.0020554967,
0.0036919117,
0.025371082,
-0.0023814493,
0.0070379144,
0.006725266,
-0.022683637,
-0.013071363,
0.013550313,
0.022989634,
0.013537009,
0.018226735,
-0.03334029,
-0.005517911,
0.008062337,
-0.026595067,
-0.027406624,
0.008973674,
-0.045074582,
-0.01919794,
-0.0093129305,
0.035096444,
0.025956467,
0.0021153656,
-0.0011183831,
-0.01659032,
0.03206309,
-0.0049458314,
0.005158698,
0.0076166466,
-0.019836541,
-0.021778952,
0.005793973,
-0.017109184,
-0.026861152,
0.002941888,
-0.031637356,
-0.013457185,
0.02310937,
-0.006359401,
0.0074104317,
0.003081582,
-0.031344663,
0.010929389,
-0.00069763826,
-0.0058338856,
-0.0060001877,
-0.04201462,
0.015259901,
-0.017588135,
-0.002294972,
-0.0041209715,
0.012399501,
-0.019370895,
-0.0027523036,
-0.030200502,
-0.0018210105,
-0.017202312,
-0.0027506405,
-0.004693052,
-0.0076232986,
0.010796347,
-0.007802905,
0.012479327,
-0.024825612,
-0.018679077,
0.007603342,
-0.0031065275,
-0.011953811,
-0.019344287,
0.013849658,
0.014075829,
0.001110068,
-0.012306372,
-0.006179794,
0.0051154597,
-0.005504607,
-0.04299913,
0.0041874927,
-0.0036220646,
0.046405002,
0.025158215,
0.005002374,
0.0126921935,
-0.0061232517,
-0.050103564,
-0.019743413,
-0.006412618,
0.028204875,
0.024493007,
0.030706061,
0.020076016,
-0.0026092834,
-0.007636603,
0.004915897,
-0.013836353,
-0.017681263,
0.009372799,
0.039992385,
0.0146479085,
-0.0047429423,
-0.030812494,
-0.010097877,
0.025650471,
-0.014248784,
-0.0060168183,
0.02100731,
-0.021406434,
0.018120302,
-0.013364055,
-0.013357403,
0.00845481,
0.015818678,
0.0086942855,
-0.04315878,
-0.012007028,
0.014195567,
-0.01855934,
-0.02940225,
-0.005996862,
-0.016044848,
0.024865523,
0.0067685046,
-0.0063926615,
-0.033739414,
0.0049292007,
-0.020767834,
0.0036120864,
0.03461749,
0.00085396244,
0.022896504,
0.008281856,
-0.033260465,
-0.03286134,
-0.02329563,
-0.012878452,
0.011328515,
0.009618927,
0.016284324,
-0.0254243,
0.0030316913,
-0.0118008135,
-0.014661213,
-0.011022518,
-0.012632324,
0.0041309497,
-0.009951531,
-0.019889759,
0.0037584326,
-0.011434948,
-0.0012971582,
0.0137565285,
0.0016214477,
-0.006173142,
0.0056243446,
-0.01931768,
0.0040311683,
0.032329172,
-0.0029734855,
-0.015991632,
-0.022377642,
-0.021685824,
-0.0038382576,
-0.031238228,
0.015845286,
0.17593455,
-0.020395318,
-0.00012618188,
0.032595254,
0.005371565,
-0.013250969,
0.00641927,
-0.012818583,
-0.021792257,
0.010177703,
-0.0017644677,
0.028870083,
-0.006642115,
-0.0011682739,
0.0387684,
-0.037145287,
-0.025264649,
0.0062496415,
-0.01029744,
0.01595172,
-0.025597254,
-0.012665585,
-0.0071177394,
-0.015619114,
0.017907435,
0.01690962,
-0.039486825,
0.0012996526,
-0.011341819,
0.009093411,
-0.022563899,
-0.0069115246,
-0.0016455615,
0.024679266,
0.019756716,
0.016044848,
0.009366147,
0.0040245163,
-0.008501375,
-0.020475142,
0.0023165913,
-0.000555034,
0.01732205,
-0.014421738,
0.006362727,
-0.014674517,
-0.008122206,
-0.019730108,
-0.011827421,
0.0069846977,
-0.02942886,
0.032941166,
0.010363961,
0.026940977,
0.0053915214,
0.00813551,
-0.010057964,
0.00069846975,
0.021459652,
0.02523804,
-0.015047034,
0.0146479085,
-0.030306935,
-0.010317396,
-0.0031630702,
0.048453845,
-0.006366053,
-0.0055378675,
0.033127423,
-0.012306372,
0.008973674,
-0.0076232986,
-0.018133605,
0.008760806,
-0.010197659,
-0.011740944,
0.044329546,
0.033154033,
0.02876365,
-0.008315116,
-0.011867334,
0.0033110792,
-0.025597254,
-0.0020222364,
0.01455478,
-0.033260465,
0.014860776,
-0.0025344475,
-0.004210775,
-0.013217709,
0.017614743,
-0.029641727,
0.012851844,
-0.011694379,
0.013104623,
0.018918553,
-0.0029551922,
0.010417177,
-0.010763086,
-0.025557341,
-0.03706546,
0.06162499,
0.016124673,
0.0056110406,
-0.014980514,
0.0019507263,
-0.004061103,
0.013576922,
0.017707871,
-0.019583762,
0.0122332,
-0.016164586,
0.00386154,
-0.005444738,
0.020688009,
-0.0032695038,
0.02961512,
-0.06322149,
0.0562501,
-0.019849846,
-0.02428014,
-0.0034158498,
-0.0013986026,
0.03397889,
-0.008734198,
0.012399501,
0.00502233,
0.015219989,
-0.005145394,
-0.022018429,
-0.0019756716,
-0.0076698633,
-0.00078328396,
-0.00013813487,
0.005028982,
-0.0141024375,
-0.0033011013,
-0.01372992,
0.005348283,
0.0033842523,
-0.0033127423,
-0.0010252538,
0.0066986578,
0.0040444727,
-0.013543662,
0.0079026865,
0.03413854,
0.018426297,
-0.0031015384,
0.0057706907,
-0.012519239,
-0.0016721699,
-0.0049724397,
-0.011900594,
0.020315493,
-0.035548784,
-0.011528078,
-0.03139788,
-0.023854407,
-0.009552405,
-0.05869807,
0.011494817,
0.020102626,
-0.023774581,
-0.011701032,
0.0009371136,
-0.16688772,
-0.016151281,
-0.011414992,
-0.043371648,
0.024107184,
0.023388758,
0.0028919973,
-0.006675375,
0.016217804,
-0.0048393975,
0.010144442,
0.014661213,
-0.037171897,
-0.03661312,
0.00047853493,
0.02329563,
0.0043537947,
0.02354841,
0.03283473,
-0.0015524322,
0.018266648,
-0.023441976,
0.0066088545,
-0.019876454,
0.0011316873,
0.013018146,
0.0029202688,
-0.031291444,
0.004071081,
-0.015659027,
-0.005371565,
0.010237571,
0.005341631,
-0.019716803,
0.00788273,
-0.0013512064,
0.011448252,
-0.00082361227,
-0.0055910842,
0.0041209715,
0.034856968,
0.018918553,
0.021699127,
0.00004968282,
-0.0038049973,
-0.0077496883,
0.007443692,
-0.012725454,
-0.0009437657,
0.008933761,
0.00791599,
-0.0037551066,
0.009299626,
0.015938414,
0.02695428,
-0.008534635,
-0.0048859622,
0.045713183,
0.020288885,
-0.000011563208,
-0.00927967,
-0.020102626,
0.029215993,
-0.0011350134,
0.03038676,
-0.007170956,
0.010357309,
0.009366147,
-0.022510683,
-0.003354318,
-0.0093129305,
-0.005803951,
0.012086853,
0.0047495943,
-0.0058172555,
0.018173518,
-0.017707871,
0.02183217,
-0.025344474,
-0.009944879,
-0.015805373,
0.012379545,
0.012732106,
-0.022630421,
-0.011321862,
-0.00874085,
0.010516959,
0.015925111,
-0.020834355,
-0.007876079,
0.010397221,
-0.020994006,
-0.020129234,
0.0017677937,
0.021938603,
0.02386771,
0.008827328,
-0.019583762,
0.00085479394,
-0.010383917,
-0.0055212374,
-0.007523517,
0.000038145598,
0.010057964,
0.0327283,
0.0058804504,
-0.010230919,
-0.0043271864,
0.03578826,
-0.0056576054,
0.0121600265,
-0.012831887,
0.01732205,
0.031770397,
0.0007126055,
0.029801376,
-0.021818865,
-0.013024799,
-0.006509073,
-0.022630421,
0.0702461,
0.006076687,
-0.017774392,
0.0010959323,
0.0044968147,
-0.022630421,
-0.12697515,
-0.0055212374,
0.01706927,
0.024572833,
0.0066886796,
0.018945161,
-0.0003274077,
0.06566946,
-0.021858778,
0.04108333,
-0.013004842,
-0.014368521,
-0.007942599,
-0.00030932232,
-0.017694568,
-0.003645347,
-0.0053383047,
-0.01627102,
-0.012146722,
0.022936417,
-0.000063194886,
-0.013823049,
0.004220753,
-0.011548034,
0.019237854,
0.010610089,
-0.02691437,
0.012885104,
0.028417742,
-0.0018393038,
-0.0064159436,
-0.015792068,
0.0074636484,
-0.0014742701,
-0.0034058716,
-0.008381637,
-0.017934043,
-0.0060301223,
0.047203254,
0.004363773,
0.003212961,
0.0069913496,
0.0023897644,
-0.017588135,
0.014089133,
-0.004812789,
-0.016869707,
0.021499565,
-0.013916179,
-0.005873798,
-0.02475909,
-0.026901064,
-0.033446725,
-0.018040476,
0.01455478,
0.000079877085,
0.0066254847,
0.02304285,
0.010363961,
0.0012406154,
-0.0032695038,
-0.0011657793,
0.0107364785,
-0.000376259,
0.005853842,
-0.024386574,
-0.020328796,
-0.025623862,
0.0333669,
-0.02459944,
-0.0013171145,
0.016483886,
-0.02208495,
-0.001173263,
-0.024546223,
-0.0035389136,
-0.028178265,
-0.024958653,
0.011634511,
-0.0069447854,
-0.011634511,
-0.02599638,
0.010949345,
0.0010443786,
-0.01560581,
0.018106997,
0.0061930986,
-0.006931481,
0.011973768,
-0.009712056,
0.0011757575,
0.024932045,
0.0001646393,
0.004772877,
0.0047296383,
0.004476859,
-0.028337916,
-0.006362727,
0.011381731,
-0.0077829487,
-0.016443973,
-0.000111630434,
-0.04531406,
0.018173518,
-0.0025244693,
-0.028737042,
0.018200127,
-0.022843288,
0.012093505,
-0.017428484,
-0.008641069,
0.05050269,
-0.019424113,
-0.0008252753,
-0.001147486,
-0.003585478,
-0.03467071,
0.017840914,
0.0148208635,
-0.015738852,
0.018160215,
0.02761949,
-0.004586618,
-0.010111181,
0.018346472,
0.02761949,
-0.009652187,
-0.016962837,
-0.004982418,
-0.0010585143,
-0.011567989,
-0.029801376,
0.0015499376,
-0.02157939,
0.00062238646,
0.013956091,
-0.012519239,
-0.018665774,
0.0012289742,
0.02615603,
0.018585948,
0.032967772,
-0.0055478457,
-0.061092824,
0.004277296,
-0.004503467,
-0.015499377,
0.00940606,
-0.010310744,
0.014395129,
-0.015885198,
-0.004197471,
0.035389137,
-0.00686496,
-0.010131137,
-0.012339633,
-0.0019141397,
0.0061831204,
-0.0052817618,
-0.020821052,
0.008567896,
-0.011128952,
0.02780575,
0.017854217,
0.0014035916,
0.012372893,
-0.013430576,
-0.0100114,
-0.009798533,
-0.011035822,
0.00804238,
-0.01796065,
0.0017411853,
0.012273111,
0.016776579,
0.028870083,
-0.01560581,
0.008667678,
-0.0028371178,
0.014794255,
-0.014328608,
0.019264461,
0.010111181,
0.011508121,
0.00772308,
0.022603812,
0.01544616,
0.008308465,
0.022710245,
0.033287074,
-0.01503373,
0.014488258,
0.002499524,
0.015047034,
0.012206591,
0.0058106035,
0.0033177314,
0.02231112,
-0.018293256,
0.022164773,
0.0058106035,
-0.007084479,
-0.00829516,
-0.0065123993,
0.00087641325,
-0.025650471,
-0.012239851,
0.01585859,
-0.013902875,
-0.042573396,
0.008614461,
-0.012253155,
0.013636791,
0.0059669274,
-0.0027240322,
0.00264587,
-0.025304561,
0.0074769524,
-0.0009495863,
-0.01757483,
-0.012638977,
0.009392755,
0.028284699,
0.031504314,
0.008481419,
-0.0061365557,
0.008727546,
0.0008664351,
0.013862962,
-0.034723926,
0.023402063,
-0.0061864466,
0.0016164586,
-0.0126921935,
-0.023082763,
-0.014927297,
-0.006229685,
0.015206684,
0.012685541,
0.016483886,
0.0046963776,
0.06417939,
0.006179794,
-0.0062729237,
0.017428484,
-0.022803375,
0.0267015,
0.011720988,
0.014355217,
-0.0031264836,
-0.01725553,
0.014754342,
-0.017614743,
0.020288885,
-0.026209246,
0.005142068,
0.026821239,
0.0039679734,
0.03820962,
-0.03954004,
-0.020009495,
0.018865336,
-0.007716428,
0.018412994,
-0.0014260424,
-0.03757102,
0.010796347,
0.042227488,
-0.014089133,
0.015712244,
-0.026302377,
0.013996004,
0.008208683,
-0.033925675,
-0.0027672707,
0.0029535294,
0.0103772655,
0.009652187,
-0.016603624,
0.016922925,
-0.0006880759,
0.0019839867,
-0.023308935,
-0.0036786075,
-0.006429248,
0.00091798883,
-0.007709776,
-0.011401688,
0.008474766,
-0.0018775533
] |
Variation in cerebral cortex size and complexity is thought to contribute to differences in cognitive ability between humans and other animals. Here we compare cortical progenitor cell output in humans and three nonhuman primates using directed differentiation of pluripotent stem cells (PSCs) in adherent two-dimensional (2D) and organoid three-dimensional (3D) culture systems. Clonal lineage analysis showed that primate cortical progenitors proliferate for a protracted period of time, during which they generate early-born neurons, in contrast to rodents, where this expansion phase largely ceases before neurogenesis begins. The extent of this additional cortical progenitor | [
0.0068311235,
0.007419322,
0.0115768155,
-0.028287001,
0.0028741518,
0.023728462,
0.0018815668,
0.018929297,
-0.045719065,
-0.02633525,
0.015346633,
0.020439899,
-0.0023177026,
-0.0026385381,
-0.0073859016,
0.02229807,
0.02713734,
-0.0034690343,
-0.005818486,
0.015480315,
-0.01919666,
0.014477704,
-0.009852325,
-0.019397182,
0.01378256,
0.018314362,
0.010153108,
-0.014210341,
-0.005908721,
-0.009384439,
0.00959833,
0.004428199,
0.006506946,
-0.020065589,
-0.016402718,
-0.0018063709,
0.012933683,
0.00654705,
0.009885745,
0.015306529,
0.008883134,
0.010467259,
-0.0041173897,
-0.010313526,
-0.0031632378,
0.010179845,
-0.020159166,
-0.005801776,
-0.02019927,
0.020226007,
0.030479377,
0.027271021,
-0.00010757181,
0.016696816,
-0.023848776,
-0.034088776,
-0.0032233945,
0.0092708105,
0.019878436,
-0.013495145,
0.0072054313,
0.004508408,
-0.007880523,
0.021897025,
-0.0036127418,
0.0076800007,
0.008308304,
0.0057549877,
0.024864754,
-0.020814206,
0.046146847,
0.004067259,
-0.0131141525,
-0.027966164,
0.012592795,
0.0044048047,
-0.045585383,
0.0007924805,
-0.0036428203,
0.007907259,
-0.0016827156,
-0.04055896,
-0.005220262,
0.021897025,
0.008462038,
0.019544233,
-0.008716032,
0.012552691,
0.012512586,
0.010086267,
0.0016192169,
0.02193713,
0.018274257,
0.008936606,
0.013916242,
-0.01068115,
-0.00743269,
0.016857235,
-0.026107993,
-0.024744442,
-0.018795615,
0.00992585,
-0.016228931,
-0.024076033,
-0.026161466,
0.0036394782,
0.013408252,
-0.00090819853,
0.017258279,
-0.018875824,
0.004164178,
0.017365225,
-0.009130444,
-0.053151757,
0.0118976515,
0.009377755,
-0.0008889818,
0.0003358747,
-0.01675029,
0.0081813065,
0.023046687,
0.005270392,
0.016482927,
-0.012298696,
0.02265901,
0.025346007,
0.004060575,
0.0014245432,
-0.0032183814,
0.006062455,
0.0021088254,
-0.0153600015,
0.0007131071,
0.017953422,
-0.010373683,
-0.0040906533,
-0.0019684597,
0.0047924807,
-0.0011688774,
-0.023327418,
-0.004886058,
0.00040543085,
-0.0062028207,
0.008281567,
-0.010968565,
0.042457238,
0.012779949,
0.018047,
0.017191438,
0.011509975,
0.0108282,
-0.008722716,
0.01689734,
0.0054976507,
0.021709872,
0.00941786,
-0.002538277,
0.030773476,
-0.018528253,
-0.0075797397,
0.007586424,
-0.0010519061,
0.0015055876,
0.009364387,
0.033660997,
0.020373058,
0.014745067,
0.012138278,
0.03058632,
-0.015988305,
-0.016362613,
0.007947364,
-0.016215563,
0.02807311,
-0.004815875,
-0.008622455,
0.008488773,
0.021308828,
-0.023153631,
-0.035425592,
0.0022074154,
0.014477704,
0.0037865278,
0.0070316456,
0.0029159272,
-0.0029643867,
0.030078333,
-0.0076733166,
-0.0056647523,
-0.010634362,
-0.015988305,
0.0020319584,
-0.0053338907,
-0.02049337,
-0.65193784,
-0.028821725,
0.0028524285,
-0.032030083,
0.0062295566,
0.023287313,
-0.00023644911,
-0.011890967,
-0.023795303,
0.018180681,
0.0015991647,
0.0062796874,
0.0014412535,
-0.016683448,
-0.01602841,
-0.012231855,
-0.007158643,
-0.0011571803,
0.012947051,
-0.0006984857,
-0.024811283,
0.0020486687,
-0.014450967,
0.019744754,
-0.0077535254,
0.017151333,
0.020252744,
-0.0013493474,
0.007359165,
0.03678914,
-0.020038852,
0.0062897136,
-0.0026970238,
-0.025372744,
0.0457458,
0.0016969192,
-0.013668931,
0.03384815,
-0.014638121,
0.048686795,
-0.004174204,
-0.0022943083,
-0.0015983292,
0.01616209,
-0.029329715,
0.007098486,
0.0036093998,
-0.021335563,
-0.008074361,
-0.007853786,
-0.0027705487,
0.01652303,
0.0012532638,
0.00073232385,
0.009337652,
-0.021629663,
0.03205682,
0.0014746737,
0.016041778,
0.0035692954,
-0.010306842,
-0.004969609,
-0.026308514,
-0.011416398,
-0.0066840737,
0.028233528,
-0.031227993,
-0.010079583,
-0.0012708096,
-0.036548514,
-0.002090444,
0.028126583,
-0.012064753,
-0.02359478,
-0.025065277,
0.019664545,
0.016509661,
-0.018782247,
-0.001988512,
0.007098486,
-0.011302769,
-0.006059113,
-0.011670393,
0.01471833,
-0.006166058,
-0.01161692,
-0.008475405,
0.009798852,
-0.012185067,
0.00543081,
0.013488461,
0.0021940472,
-0.0009165536,
-0.055878855,
-0.008929922,
0.024650864,
-0.0046989038,
-0.010614309,
0.0010377024,
-0.024904858,
-0.009838956,
-0.0036762406,
-0.0012181725,
0.021536086,
0.0388211,
0.011877599,
-0.029409925,
0.006971489,
0.05571844,
-0.03686935,
-0.0022692431,
0.017592482,
0.002163969,
0.0041340995,
0.01537337,
-0.015867991,
0.013809296,
-0.002254204,
-0.03168251,
-0.018889192,
0.018862456,
-0.011276033,
-0.008208043,
-0.016763657,
0.0349176,
0.0020436556,
0.0030546216,
-0.0057516457,
-0.013876137,
0.008101097,
-0.020413162,
-0.0002844909,
0.014370759,
-0.023327418,
0.023755198,
0.02807311,
0.009224022,
-0.015841255,
-0.012051385,
-0.011416398,
-0.02221786,
-0.015319897,
0.0013668931,
-0.00045994783,
-0.016656712,
-0.021977235,
-0.01717807,
-0.00086475204,
-0.005624648,
-0.015640732,
0.001809713,
-0.015761046,
-0.0063832905,
0.0036528464,
0.012499218,
-0.0045618806,
-0.0076532643,
-0.03074674,
0.004525118,
-0.027003659,
-0.013067365,
0.029810969,
-0.0023143606,
0.024664233,
-0.015961569,
-0.008201359,
-0.015025798,
0.015720941,
-0.000011285902,
-0.036521778,
-0.011068827,
-0.002179008,
0.02366162,
0.012245223,
-0.013729088,
-0.00060407317,
-0.01064773,
-0.009130444,
-0.022538697,
0.00017399479,
0.0031314886,
-0.0042009405,
-0.0056413584,
-0.023180367,
0.027177444,
0.014491072,
0.04090653,
0.009932534,
-0.0032116976,
0.03751102,
0.022739219,
0.04432878,
-0.0054943087,
-0.0018381203,
0.002082089,
-0.012525954,
0.002352794,
0.0056781205,
-0.0013468409,
0.031735983,
0.019664545,
0.0035759795,
0.00097503926,
-0.017084492,
0.04259092,
-0.024142874,
-0.013140889,
-0.010133056,
-0.012793317,
0.00561128,
-0.0045518545,
0.011596868,
-0.0053873635,
-0.019637808,
-0.01919666,
0.012225171,
-0.000015900785,
-0.016683448,
-0.018648567,
-0.011550079,
0.012325432,
0.0015966581,
-0.00050172326,
0.0020520107,
-0.012893578,
0.034329403,
-0.013408252,
0.027752275,
0.010594257,
-0.017579114,
-0.017859844,
0.01890256,
0.014745067,
0.0025031855,
0.005460888,
0.021188514,
0.017552378,
-0.0115768155,
0.0071185385,
0.008716032,
0.009444596,
0.0133748315,
0.0049228203,
-0.015507051,
-0.0027755618,
-0.018929297,
0.03991729,
0.00007201045,
-0.011463187,
0.02433003,
-0.0153600015,
-0.0067408886,
-0.025733683,
-0.0038466845,
0.019383814,
0.023140263,
-0.010908408,
0.0015465276,
0.027404703,
0.03812596,
0.009691907,
-0.011102247,
0.0042844913,
-0.0049228203,
-0.008167938,
-0.00018412534,
0.022284701,
-0.026936818,
0.0073792175,
-0.0028407313,
-0.02252533,
0.004164178,
-0.0011546738,
-0.032725226,
-0.020172535,
0.0063799485,
0.004361358,
-0.0027588515,
0.019129818,
0.027070498,
-0.0097186435,
-0.013916242,
-0.003452324,
0.031067574,
-0.013087416,
-0.013287939,
-0.029623816,
-0.024383502,
-0.015159479,
-0.0081813065,
-0.016322508,
0.0042911754,
-0.012191751,
-0.006707468,
-0.013769192,
-0.019744754,
0.0063030818,
0.008789557,
0.01486538,
-0.008983395,
0.013261203,
0.015547155,
-0.02489149,
-0.0025516453,
0.037270397,
0.021990603,
-0.017418696,
-0.0007782768,
0.0032083555,
-0.016870603,
-0.0080476245,
-0.0101664765,
-0.004722298,
0.028340474,
0.0031665799,
0.0003231332,
0.010781411,
0.0076599484,
0.027672065,
0.015025798,
-0.006400001,
-0.022899637,
-0.022565434,
-0.024263188,
0.021308828,
0.023554675,
-0.0064902357,
0.010721254,
0.0154268425,
-0.006904648,
-0.025706949,
-0.006259635,
0.036922824,
-0.008622455,
-0.021923762,
-0.03074674,
0.027511647,
-0.018795615,
0.03890131,
0.024731074,
-0.01781974,
-0.008595719,
-0.01378256,
0.007045014,
0.018341098,
0.01645619,
0.018915929,
0.036708932,
0.020774102,
0.01616209,
0.012318748,
0.028634572,
-0.005815144,
0.000026227157,
-0.025733683,
0.024142874,
-0.013047312,
0.010400419,
0.01342162,
-0.004819217,
-0.0031415147,
0.0090101315,
0.0116436565,
0.02410277,
-0.004060575,
0.030613057,
0.0045752483,
-0.021402404,
0.021749977,
0.002262559,
0.0022709141,
0.0022441777,
-0.0040973374,
-0.023781935,
0.016295772,
-0.012766581,
-0.015386738,
0.0028357182,
0.010788095,
0.0033169717,
-0.008802925,
-0.007913943,
0.0033988515,
-0.019236764,
-0.006998225,
-0.015613996,
0.003973682,
-0.015573892,
-0.008027572,
-0.013047312,
0.00260846,
0.0046721674,
-0.029062353,
-0.004892742,
0.010514048,
-0.015239689,
-0.029062353,
0.007599792,
0.009183917,
0.029864442,
0.02662935,
-0.010079583,
-0.0013693996,
0.021910394,
0.0104271555,
-0.028554363,
0.0010159792,
-0.0027454833,
0.0017027678,
0.0066439696,
0.0012048043,
-0.0316023,
0.010099635,
-0.008000837,
0.009424544,
-0.031254727,
-0.0228729,
0.00739927,
-0.0059254314,
-0.013227782,
0.01934371,
0.026308514,
0.00090318546,
-0.018768879,
-0.0007005745,
-0.029169299,
-0.0041073635,
-0.01086162,
0.011630288,
-0.008809609,
0.00433128,
-0.013274571,
-0.02280606,
-0.028607836,
0.035024546,
-0.033687733,
0.030425904,
0.008341724,
0.01479854,
0.00068135775,
0.01573431,
0.012779949,
0.006503604,
-0.029757496,
-0.009645118,
-0.013047312,
0.039596453,
0.007058382,
-0.027297758,
0.0005568669,
0.0058318544,
-0.0069313846,
-0.025773788,
0.0038801047,
0.0052336296,
0.018996138,
-0.012793317,
-0.016255667,
-0.003448982,
-0.005815144,
-0.014771803,
0.013488461,
-0.008268199,
0.008355092,
-0.010153108,
0.00026819846,
0.0021506008,
-0.0031849612,
0.022231229,
-0.036922824,
-0.009264126,
0.008963343,
0.0174588,
0.0060223504,
-0.022899637,
0.0071118544,
-0.021669768,
-0.0060825073,
-0.024076033,
-0.017926686,
-0.003716345,
-0.037350606,
0.03622768,
0.024009192,
0.03023875,
0.005313839,
0.021121673,
0.039649926,
-0.0022742562,
-0.009244074,
0.013742455,
0.011483239,
-0.019677913,
0.016937442,
-0.021990603,
-0.0010427155,
0.009899113,
0.0005246998,
0.020733997,
0.03304606,
-0.0198517,
-0.02100136,
0.012532638,
-0.03513149,
-0.023167,
0.017739533,
-0.0016058488,
-0.013942978,
-0.015440211,
-0.0016534728,
0.014156869,
0.0061259535,
-0.008201359,
-0.0069113323,
0.013742455,
-0.006146006,
0.0024229768,
-0.0028139951,
0.017418696,
-0.0024747783,
0.0008697651,
-0.0075797397,
-0.0138226645,
0.008983395,
-0.0063231336,
0.024584023,
0.023300681,
0.012044701,
0.0048426115,
0.021602927,
-0.015253057,
-0.0036027157,
-0.0010719583,
-0.03406204,
0.002539948,
-0.017766269,
-0.0104873115,
-0.0077201054,
-0.014624753,
0.014838644,
-0.020105693,
0.031415146,
-0.023126895,
-0.01667008,
0.03860721,
-0.0020002092,
0.038072485,
-0.014410863,
0.019570967,
0.023875512,
0.0076398966,
-0.016696816,
-0.0024664232,
0.00041900788,
-0.0069180164,
0.028393945,
0.028821725,
-0.010514048,
-0.017873213,
-0.0036361362,
0.025747051,
-0.018260889,
-0.0433128,
0.004418173,
0.00344564,
0.0019266843,
-0.010113004,
-0.00685786,
-0.014370759,
-0.0063231336,
-0.02019927,
-0.00089315936,
-0.0030930552,
-0.016696816,
-0.022097548,
0.017164702,
-0.0017996869,
0.0063766064,
0.0069247005,
0.025452953,
-0.01709786,
-0.00046161885,
-0.00804094,
-0.000024490864,
0.002996136,
-0.002997807,
-0.008716032,
0.00036240212,
0.012031333,
-0.0019049611,
-0.003448982,
-0.003619426,
-0.0067509147,
0.037564494,
-0.006794361,
-0.01811384,
0.0032300786,
0.005898695,
0.01522632,
-0.018354466,
0.0032083555,
-0.01883572,
-0.0228729,
0.0029593736,
0.033607524,
0.0036962929,
0.007238852,
-0.0154936835,
-0.011349557,
-0.0074661104,
-0.043179117,
-0.010159792,
0.0009984336,
-0.030880421,
-0.0012749871,
0.03890131,
0.015199584,
0.0011855876,
-0.011416398,
-0.016362613,
0.010133056,
0.019597704,
-0.015159479,
0.017766269,
0.019022875,
0.004862664,
-0.06336502,
-0.0019316974,
-0.009190601,
-0.005898695,
-0.0014663187,
-0.048686795,
-0.038740892,
0.012693056,
-0.0011630289,
0.014932221,
-0.0174588,
0.0048325853,
-0.0026468933,
0.01977149,
0.004605327,
-0.010119688,
-0.0261882,
0.0062228725,
-0.008782873,
-0.016843867,
0.008956659,
-0.026375355,
0.009016816,
-0.026736295,
-0.0056814626,
0.024731074,
-0.039436035,
0.012312064,
-0.008963343,
0.013394884,
-0.023420995,
0.0080476245,
-0.028875198,
-0.017833108,
-0.021776712,
-0.004351332,
-0.0033219848,
-0.0071853795,
-0.015386738,
0.020934518,
-0.002436345,
-0.0030930552,
-0.0072655883,
-0.010881673,
0.00923739,
-0.035692953,
-0.036094,
0.0051801573,
-0.011509975,
0.036628723,
0.021629663,
0.0009315928,
-0.025426216,
-0.0017052743,
-0.04323259,
-0.024784546,
0.009772116,
0.027190812,
0.008776189,
0.024477078,
0.006306424,
-0.0069247005,
0.0111289825,
0.0045585386,
-0.013234466,
-0.025947575,
-0.0026953528,
-0.012038017,
0.0014855354,
-0.0018815668,
-0.007245536,
0.0007168669,
0.024985068,
-0.010266737,
-0.013521881,
0.012626216,
-0.0030897132,
0.03737734,
-0.008970027,
0.036896087,
0.007151959,
0.014303918,
0.00546423,
-0.035265174,
0.0025783814,
0.00580846,
-0.020680524,
-0.0040371804,
-0.0016192169,
-0.015266425,
-0.012205118,
0.0031866322,
-0.014049923,
-0.018528253,
0.020439899,
0.0044014626,
0.012285328,
-0.002092115,
0.018421307,
0.017298384,
0.02295311,
-0.008161254,
-0.006991541,
-0.0033386948,
0.0015222979,
-0.0011103918,
0.004909452,
-0.00782705,
0.01695081,
-0.0028424023,
0.013361463,
-0.04884721,
-0.006864544,
-0.017619219,
-0.0008363447,
-0.00452846,
0.033153005,
0.0042911754,
-0.026976923,
0.0141435005,
0.018207418,
-0.015052535,
-0.017953422,
-0.000020326373,
-0.008167938,
-0.014691594,
0.002282611,
-0.0073658493,
-0.013174309,
-0.0144643355,
-0.0067809927,
0.001038538,
-0.0062796874,
-0.0025800525,
0.17549704,
-0.00779363,
0.010821516,
0.015159479,
0.013187678,
-0.0040973374,
0.012178383,
-0.0026669453,
0.0029125852,
0.007546319,
0.007165327,
0.010848252,
-0.029329715,
0.007359165,
0.041013476,
-0.01522632,
-0.008582351,
-0.01875551,
-0.0019784858,
-0.005962194,
0.01092846,
-0.023969088,
0.013942978,
-0.008107781,
0.03045264,
0.003522507,
-0.02531927,
-0.016777026,
0.01999875,
0.015961569,
-0.017712796,
0.015453579,
-0.0042410446,
0.014170237,
-0.005521045,
-0.013956347,
-0.012746529,
0.002636867,
-0.003261828,
-0.016175458,
0.017793005,
0.004160836,
0.034516558,
0.019744754,
-0.0033320107,
0.03593358,
0.024690969,
-0.005875301,
0.0044883555,
0.0017478853,
-0.026455564,
0.024062665,
0.008736084,
0.025773788,
-0.0026619325,
0.005521045,
0.014103396,
0.0132478345,
0.004471645,
0.033233214,
-0.020533474,
0.0174588,
-0.017164702,
0.026121361,
0.0031949873,
0.00844867,
0.00043822458,
-0.0034757184,
0.005875301,
-0.022485225,
-0.010086267,
-0.014130132,
0.002727102,
0.0024179637,
0.0017813056,
-0.025519794,
0.04042528,
0.0040071025,
0.021322196,
0.001637598,
0.024637496,
-0.009130444,
-0.018608462,
-0.014557913,
-0.019972013,
-0.031254727,
0.030720003,
0.01753901,
-0.023608148,
-0.02656251,
-0.0026619325,
-0.016255667,
-0.017632587,
-0.028821725,
-0.0006542037,
-0.01486538,
0.022632275,
0.009544858,
-0.0038667368,
-0.02323384,
-0.030800212,
0.060744863,
0.031709246,
0.022231229,
-0.009050236,
0.011483239,
0.01608188,
0.04120063,
0.0023310708,
-0.0023009924,
-0.011991228,
-0.017552378,
-0.0015740994,
0.008060993,
-0.0001324282,
0.027618593,
0.00022203657,
-0.03291238,
0.036414836,
-0.010219949,
0.01241901,
-0.033447105,
-0.014598018,
0.03334016,
-0.0060256924,
-0.023407627,
-0.0042410446,
0.015988305,
-0.0008430288,
-0.023220472,
-0.009003447,
-0.022070812,
0.004438225,
0.009658487,
0.01709786,
0.008014205,
0.020453265,
-0.0070383297,
0.0009558225,
0.008462038,
-0.004912794,
-0.018287625,
0.010313526,
-0.010968565,
0.0138226645,
-0.0122184865,
0.017204806,
0.027003659,
0.0034389559,
-0.024998436,
-0.010901724,
-0.014531177,
0.010280105,
0.005524387,
0.013635511,
-0.014223709,
-0.007258904,
-0.018595094,
-0.001401149,
-0.0038667368,
-0.026869977,
0.022712482,
-0.007519583,
0.000011906007,
-0.010955197,
-0.0062195305,
-0.16865255,
-0.0005752481,
0.045237813,
-0.01638935,
0.025613371,
0.006343186,
0.004795823,
-0.025198959,
0.004718956,
0.0066439696,
0.027698802,
0.0012123239,
-0.027404703,
-0.012706424,
0.01371572,
-0.016937442,
0.0042811492,
0.02756512,
0.0060457448,
0.009097025,
0.03074674,
-0.02172324,
0.023768567,
-0.0011162403,
0.013314675,
-0.017084492,
-0.0042143087,
-0.008816293,
0.00959833,
-0.055397604,
0.0019266843,
-0.022886269,
0.029650552,
0.0038299742,
-0.0027738907,
-0.01035363,
-0.0077401577,
-0.023126895,
-0.01392961,
-0.0035759795,
0.020546842,
0.02850089,
0.0154936835,
-0.008836346,
-0.0077468418,
0.033928357,
-0.010400419,
-0.026575878,
0.017485537,
-0.014918853,
0.017552378,
0.005855249,
-0.005417442,
0.01977149,
0.022819428,
-0.005507677,
0.027164076,
0.016964179,
0.0022775983,
-0.003154883,
-0.014999062,
-0.014985694,
0.023875512,
-0.001901619,
-0.017311752,
-0.017926686,
0.0070784343,
0.018875824,
-0.03759123,
0.018915929,
-0.014130132,
-0.00905692,
0.011015354,
-0.046093374,
0.026201569,
0.01949076,
-0.016228931,
-0.0009884074,
-0.0023076765,
0.02461076,
0.00012271541,
0.008261515,
-0.026442196,
-0.003425588,
-0.04489024,
-0.010113004,
0.004705588,
0.017712796,
0.00689128,
-0.002636867,
0.000042402095,
-0.031361673,
-0.01819405,
-0.0070249615,
0.033393633,
0.020693893,
-0.004625379,
-0.021482613,
0.000109660585,
-0.016843867,
0.014571281,
-0.008348408,
-0.030693267,
-0.0044081467,
0.036628723,
0.007907259,
-0.022284701,
0.0007816189,
0.055932328,
0.006516972,
0.0009132116,
0.014477704,
0.0071920636,
0.023006583,
-0.018033631,
0.035880107,
-0.0032651701,
-0.008187991,
0.028901935,
-0.011763969,
0.06266987,
0.010661098,
-0.01760585,
0.020747365,
-0.0069781733,
0.0027471543,
-0.14341348,
-0.022538697,
-0.0154936835,
0.06234904,
-0.011122298,
0.0039402614,
-0.008067677,
0.03325995,
-0.024236452,
0.042109665,
-0.002610131,
-0.017993527,
0.017432064,
0.0005230288,
0.0029460054,
-0.013521881,
-0.00833504,
0.006801045,
-0.0048392694,
0.02424982,
0.01486538,
-0.008709348,
0.001130444,
-0.008134518,
0.0044014626,
0.02959708,
-0.03342037,
0.010313526,
0.0174588,
0.010547468,
0.01399645,
-0.03529191,
0.017258279,
0.0027939428,
-0.007519583,
-0.006811071,
0.0050431336,
-0.03176272,
0.044783294,
-0.0002788512,
-0.004257755,
-0.008655876,
0.008248147,
-0.0006508617,
-0.019597704,
-0.010072899,
-0.0066306014,
-0.0071319067,
0.000497128,
-0.031201256,
-0.029837705,
-0.021950498,
-0.010707886,
-0.0066707055,
0.017833108,
-0.027591856,
0.024450341,
0.0068411496,
-0.002431332,
-0.00009357704,
-0.0015774415,
-0.00006631854,
-0.033366896,
0.006055771,
0.03096063,
-0.011209192,
-0.03962319,
-0.05165452,
0.012258591,
-0.013341411,
0.013321359,
0.029196035,
-0.010019426,
-0.006697442,
-0.014958957,
0.0054943087,
-0.0138226645,
0.00118141,
-0.010012742,
-0.001584961,
-0.0033888253,
-0.019637808,
0.023728462,
-0.018047,
-0.0067408886,
0.016108617,
0.0042042825,
-0.0038199483,
0.0076532643,
-0.027164076,
-0.007693369,
0.008395197,
0.0130539965,
-0.028688045,
0.0032935773,
-0.005350601,
0.005420784,
-0.0023928983,
0.026455564,
0.02280606,
-0.015052535,
-0.01638935,
-0.043098908,
0.014638121,
0.0022040734,
-0.007806998,
0.017833108,
-0.0046554576,
-0.0046454314,
-0.009992691,
-0.011175771,
0.017191438,
-0.008669244,
0.007686685,
-0.027217548,
0.009090341,
-0.027244285,
-0.025198959,
0.021161778,
-0.012960419,
-0.00044950398,
0.003258486,
0.017445432,
-0.007238852,
0.015961569,
0.0025483032,
-0.039302353,
-0.00062287215,
-0.023180367,
0.0056747785,
0.0047490345,
0.0005109139,
0.0005063186,
-0.043366272,
-0.0020052223,
0.0071118544,
0.0003202089,
-0.005407416,
0.023755198,
0.0285811,
0.010126372,
0.04804512,
-0.019530864,
-0.032591544,
0.012499218,
-0.01179739,
-0.0044916975,
0.006059113,
-0.03443635,
0.004899426,
-0.0071252226,
0.009170549,
0.022819428,
0.0003580157,
0.0072722724,
-0.036521778,
-0.009825588,
-0.005511019,
-0.0028507574,
-0.00009749348,
0.0056680944,
-0.009210654,
0.020693893,
0.011276033,
0.019103084,
-0.005263708,
-0.009043552,
-0.009304231,
-0.017739533,
0.015466947,
-0.023033319,
0.0023310708,
-0.011463187,
-0.0010652742,
0.019397182,
0.0053004706,
0.010480627,
-0.013488461,
0.012800002,
0.0012983814,
-0.017859844,
0.02193713,
0.0009616711,
-0.00041399483,
-0.006256293,
0.029222772,
0.03197661,
-0.003619426,
0.0050230813,
0.03473045,
-0.022418384,
0.0066439696,
0.023354154,
0.016135354,
0.01089504,
0.005888669,
0.006958121,
0.023621516,
-0.019370446,
0.004083969,
0.016188826,
0.018020263,
-0.002357807,
0.0031465278,
0.00869598,
-0.016990915,
-0.01608188,
-0.004982977,
-0.021402404,
-0.023581412,
-0.010420471,
0.017231543,
0.0195576,
-0.0013602091,
0.01811384,
-0.0034924285,
-0.024182979,
0.023902249,
0.0021723239,
-0.0030679898,
-0.02049337,
0.0055745174,
0.0040973374,
0.015613996,
-0.010901724,
0.0019634466,
0.011677077,
0.017218174,
0.029864442,
-0.029650552,
0.022177758,
0.007546319,
0.0113829775,
-0.013007208,
-0.013508514,
-0.011423082,
-0.016188826,
-0.03312627,
-0.018581726,
0.03347384,
-0.028367208,
0.08058319,
-0.003081358,
-0.019009506,
-0.009210654,
-0.019677913,
0.0162423,
-0.0022458488,
0.02489149,
-0.018648567,
-0.02114841,
0.02641546,
-0.025720317,
0.031923138,
-0.012492534,
-0.004521776,
0.0056313323,
-0.016041778,
0.012980471,
0.011135667,
-0.018595094,
0.033580787,
-0.014838644,
0.013836033,
0.01608188,
-0.029356452,
-0.016549766,
0.018942665,
-0.0073792175,
-0.0063231336,
-0.019584335,
0.0110019855,
0.0052135778,
-0.050905906,
0.0064902357,
-0.02416961,
0.014811908,
-0.000497128,
-0.0126061635,
-0.017672691,
0.012726476,
-0.00030203658,
-0.008101097,
-0.01558726,
-0.009544858,
-0.012452429,
-0.02531927,
-0.009972638,
-0.021923762,
-0.011376293
] |
We describe a technique for rapid labeling of a large number of cells in the nervous system with many different colors. By delivering lipophilic dye-coated particles to neuronal preparations with a "gene gun," individual neurons and glia whose membranes are contacted by the particles are quickly labeled. Using particles that are each coated with different combinations of various lipophilic dyes, many cells within a complex neuronal network can be simultaneously labeled with a wide variety of colors. This approach is most effective in living material but also labels previously fixed material. In living material, labeled neurons continue to show normal synaptic responses and undergo dendritic remodeling. This technique is thus | [
-0.037939392,
0.044103213,
0.0065258145,
-0.01127156,
-0.024376325,
-0.002973978,
-0.012978566,
0.019926151,
-0.024429461,
-0.027165985,
0.0015044244,
0.025505474,
-0.019514343,
0.011557167,
-0.011417684,
-0.01454609,
0.037939392,
0.014240555,
-0.008727654,
0.0032379995,
-0.018889992,
0.034937184,
0.0005583473,
-0.016538706,
-0.009723961,
0.0121483095,
0.0047855973,
-0.032306932,
-0.01529,
0.010168979,
-0.013529857,
-0.0024293298,
0.001027027,
-0.012885577,
-0.008913632,
0.001023706,
0.020949027,
-0.011185213,
0.009963076,
-0.0020025782,
0.015821364,
0.0021503638,
0.0019627258,
-0.010394809,
-0.002585418,
-0.0032081103,
-0.03012834,
-0.0060143764,
-0.015210295,
0.017853832,
0.04625524,
0.010706985,
-0.02245013,
-0.028773362,
-0.020696629,
-0.015449408,
0.015462693,
0.0040217615,
-0.016711399,
-0.035495117,
-0.003450545,
-0.007664926,
-0.011902554,
0.012374139,
-0.020510651,
0.0014720444,
-0.005008106,
0.023898097,
0.01873058,
-0.008216216,
0.010255326,
0.007844261,
0.0011291485,
0.0022998098,
0.023991086,
-0.004254233,
-0.030340886,
-0.0042841225,
0.018943127,
0.02371212,
0.018491467,
-0.021493675,
-0.00845533,
0.009916581,
0.019301798,
0.0041479603,
0.008368983,
0.0071999826,
-0.007140204,
-0.01477192,
0.0008510127,
0.04237628,
0.024402892,
0.0007036422,
0.0088140005,
0.017428739,
0.011670082,
0.02834827,
0.00060442655,
-0.026422076,
-0.027205838,
0.018929843,
-0.007744631,
-0.022104744,
0.010049422,
0.0030951954,
0.025359347,
-0.008116585,
0.01920881,
-0.0010021194,
0.010859752,
0.03265232,
-0.0037693635,
-0.050745264,
0.03706264,
0.0022184448,
0.014599226,
-0.007253119,
-0.00089999783,
-0.0140147265,
0.008362342,
0.02504053,
0.01950106,
-0.0030819112,
0.03156302,
0.025784438,
0.0045863357,
-0.011145361,
-0.00579851,
0.0067682494,
0.004881907,
0.0100892745,
-0.0021038693,
0.021281129,
-0.017016932,
-0.008043523,
0.02559846,
0.023738688,
-0.023645699,
-0.019979287,
0.022835368,
0.025292927,
0.00041388275,
0.0099896435,
0.0024708428,
0.048646376,
0.017906968,
0.03706264,
-0.0022665996,
-0.00068869756,
0.011171929,
-0.004742424,
0.021892197,
0.005652385,
-0.009385217,
0.028720226,
0.010501081,
0.022808801,
-0.01853132,
0.005682274,
0.0028743471,
0.005519544,
0.0053335666,
0.014054579,
0.015688522,
0.030261181,
-0.008840569,
0.0050712056,
0.003379143,
-0.018863423,
0.005303677,
0.036398437,
-0.0051176995,
0.029171884,
-0.015436125,
0.022915073,
0.021108435,
-0.0047125346,
-0.012267867,
-0.019514343,
0.009345365,
0.011796282,
-0.0060376236,
-0.007033931,
0.0023761934,
0.0147055,
0.0064095785,
-0.025784438,
0.01250698,
-0.0052903933,
-0.01778741,
0.0035136447,
-0.023459721,
-0.029729817,
-0.64656377,
-0.015130591,
0.02569145,
-0.015821364,
0.012546833,
0.04636151,
0.0035335708,
-0.020430947,
0.0024210273,
0.018611025,
-0.0048586596,
-0.0064427885,
0.0017867115,
-0.0127394525,
-0.008395552,
-0.013842032,
0.011470821,
-0.0061671436,
0.018132797,
-0.005004785,
-0.033715047,
-0.014054579,
-0.019235378,
0.027099565,
0.012746095,
0.028241998,
0.03825821,
-0.004064935,
-0.010408093,
0.0060309814,
-0.041632373,
0.0011125434,
-0.008123227,
-0.0063763685,
0.04917774,
0.007724704,
-0.014200703,
0.032306932,
0.009890012,
0.02983609,
-0.02290179,
-0.024044221,
-0.01571509,
0.012015469,
-0.026515065,
0.006190391,
-0.0027979636,
-0.004064935,
0.0045066313,
-0.023393301,
0.02510695,
0.0074390965,
-0.018611025,
0.0036597697,
0.006452752,
0.023366733,
-0.009763814,
0.019912867,
0.0025439053,
-0.002643536,
-0.015197011,
-0.028667089,
-0.0033260067,
-0.007877472,
-0.021161573,
0.008760864,
-0.01972689,
-0.019022832,
0.007312897,
-0.0093055125,
0.014200703,
0.006060871,
-0.005170836,
-0.000071038805,
-0.0046926085,
0.015343136,
0.029251589,
-0.004363827,
-0.013788897,
0.01088632,
-0.013828749,
-0.010447945,
-0.030022068,
0.016459001,
0.014984465,
0.0101889055,
-0.0148649085,
0.022994777,
0.0072331927,
0.00018359043,
-0.0062966635,
0.017747559,
-0.021958617,
-0.048194718,
-0.034671504,
-0.0005380061,
-0.008594813,
-0.013191111,
0.012035395,
-0.010441303,
0.0002010258,
-0.028082589,
0.001545107,
0.005828399,
0.019421356,
0.017614717,
-0.024376325,
0.039985143,
0.02533278,
-0.01959405,
-0.008993336,
-0.016073762,
-0.021267844,
-0.006791496,
-0.001496952,
-0.01920881,
0.008010313,
0.009983001,
0.008568245,
-0.03645157,
0.002296489,
-0.017149774,
-0.005267146,
0.015037602,
0.0065158512,
-0.010806615,
-0.00563578,
-0.016419148,
-0.0014986126,
-0.0064427885,
0.0033774825,
-0.009644257,
0.016631695,
-0.011776355,
0.0031832026,
0.019421356,
0.010315104,
-0.0065623457,
-0.005818436,
-0.04208403,
-0.020351242,
0.008661234,
0.018225785,
0.0028843104,
-0.01163023,
-0.0023180756,
-0.032705456,
0.0030105093,
-0.013264175,
-0.008833927,
-0.01036824,
-0.011278201,
-0.003988551,
0.019408071,
0.02458887,
-0.005041316,
-0.020696629,
-0.008774148,
-0.00082818064,
-0.02170622,
0.0009954773,
0.01477192,
-0.00007321822,
0.012360856,
-0.032253794,
-0.022011755,
0.015754944,
0.021825777,
0.010793332,
-0.025292927,
0.020577071,
-0.022396993,
-0.014785204,
0.015210295,
-0.009963076,
-0.008687802,
0.002555529,
-0.005675632,
-0.0028129083,
-0.017056786,
-0.004719177,
-0.004197776,
0.0048320917,
-0.0006023509,
0.038736437,
-0.009199239,
0.031642728,
0.04046337,
-0.015901068,
0.03042059,
0.015263432,
0.014492954,
-0.024323188,
-0.0053335666,
-0.0076117897,
-0.00690109,
0.02215788,
-0.020072276,
0.005446481,
0.029039044,
0.019354934,
-0.007651642,
-0.0040782187,
-0.0045564463,
0.031191068,
-0.026833883,
0.01625974,
-0.023977801,
-0.015914353,
0.016724683,
0.00042965764,
-0.012267867,
-0.003379143,
-0.026103258,
0.015104022,
0.015303284,
-0.0001519369,
-0.009670825,
-0.004998143,
-0.004513273,
-0.0013416942,
-0.021015447,
0.037912823,
-0.009730604,
-0.01898298,
0.020949027,
0.013669339,
0.020763049,
-0.010341672,
-0.024323188,
-0.003362538,
0.010746838,
-0.0052106883,
0.018132797,
-0.0019926152,
0.0059247087,
0.001687911,
-0.01101252,
0.016990365,
0.03347593,
0.023698835,
0.024349757,
0.0074656643,
-0.003042059,
0.004250912,
0.00052430684,
0.0034804344,
-0.00026070047,
-0.017867114,
-0.001730254,
-0.0039022046,
0.012613254,
-0.015197011,
0.004237628,
-0.004888549,
-0.023207324,
0.03158959,
0.0062435274,
0.024642006,
0.023818392,
0.016578557,
0.0044368897,
-0.0068081017,
-0.029304726,
-0.004921759,
-0.0046793246,
0.011523957,
-0.009411785,
-0.016897377,
-0.008794075,
-0.006210317,
-0.0017053464,
0.013775612,
-0.037992526,
0.010421377,
-0.0063498,
0.015329852,
0.021135004,
0.035920206,
-0.0062402063,
-0.026541634,
-0.002973978,
0.015555682,
0.025651598,
-0.012154952,
-0.03249291,
-0.02805602,
-0.011211781,
-0.0132841,
-0.027391816,
0.035654526,
0.0033940878,
0.0070272894,
0.0027780375,
-0.019102536,
-0.01830549,
0.0299955,
-0.0026020233,
0.013403658,
-0.030181477,
-0.0067649283,
0.014984465,
-0.009909939,
-0.018876707,
0.035760798,
0.008900347,
-0.008016955,
0.0033459328,
0.015555682,
-0.020763049,
-0.0057653,
-0.006592235,
0.0022350498,
-0.00812987,
0.023380017,
0.014758635,
-0.022423562,
0.016087046,
0.030659704,
0.01373576,
-0.010932814,
-0.036903232,
0.0062468485,
-0.019315083,
0.02983609,
0.015542397,
-0.0018946448,
0.012573401,
-0.016578557,
-0.02445603,
-0.013549782,
-0.003038738,
0.030925386,
-0.01972689,
-0.020616924,
0.008807358,
0.0017053464,
0.0009788722,
0.009584478,
0.014825056,
-0.005396666,
-0.019859731,
-0.004722498,
0.0044335686,
-0.00032255455,
0.004224344,
0.021347549,
0.011716576,
0.016804388,
-0.007923966,
0.04399694,
0.021081867,
0.0042841225,
-0.009385217,
-0.0009572855,
-0.003553497,
0.022197733,
0.004775634,
-0.03411357,
-0.022038322,
-0.0060542286,
0.015701806,
0.01499775,
-0.0018249033,
0.015834648,
0.00735275,
-0.0033558959,
-0.0066719395,
0.0011175249,
-0.012845725,
0.003583386,
-0.014054579,
-0.026103258,
-0.023645699,
0.05552754,
-0.02650178,
0.00034185802,
-0.00981695,
-0.002221766,
-0.001052765,
-0.008634665,
-0.01675125,
0.0069409427,
0.003556818,
-0.0005708012,
-0.004141318,
-0.00093320804,
-0.014519522,
-0.039480347,
-0.017056786,
0.014519522,
0.011344622,
-0.003971946,
-0.022835368,
0.0023595884,
-0.04110101,
-0.026900304,
-0.012971925,
0.02760436,
0.02510695,
0.014838341,
-0.012141668,
-0.0014404947,
0.03251948,
-0.017229479,
-0.017096637,
-0.0012345911,
-0.018797003,
0.010281893,
0.010275252,
0.009657541,
-0.01934165,
-0.018504752,
0.012015469,
0.021958617,
-0.019354934,
-0.0006799799,
0.017056786,
-0.027498089,
0.01807966,
0.02310105,
0.017455308,
-0.006881164,
-0.026236098,
-0.0017219515,
-0.028985908,
-0.0259837,
-0.020656776,
-0.021281129,
-0.01707007,
0.005821757,
-0.003583386,
-0.009949791,
0.02112172,
0.005157552,
-0.028667089,
0.017508445,
0.011490747,
0.026329087,
0.019873014,
-0.00038378595,
0.01914239,
0.008382267,
-0.002176932,
0.028135724,
-0.04030396,
0.021985186,
0.0014122659,
-0.03573423,
0.019780025,
0.008329131,
-0.019859731,
-0.0034970394,
-0.009909939,
0.005582643,
0.036239028,
0.010873036,
-0.03251948,
-0.011955691,
-0.010866394,
-0.0062800585,
0.0072066244,
-0.014904761,
-0.016140182,
-0.001049444,
0.011690008,
0.0070870677,
-0.016206603,
0.015940921,
-0.036265593,
0.0062933424,
0.01218152,
0.0070870677,
0.02209146,
-0.0010037798,
-0.01156381,
-0.02254312,
-0.010354957,
-0.0028361555,
-0.018385194,
0.015608818,
0.0020158621,
0.03148332,
0.020683344,
0.022051606,
0.010401451,
-0.01869073,
0.026847167,
-0.0033193645,
0.01321768,
-0.006921016,
0.0072265505,
-0.016897377,
0.00783762,
0.008395552,
-0.021533526,
0.012912146,
-0.01914239,
0.020935742,
0.011152002,
-0.0018913238,
-0.019354934,
0.005971203,
-0.034963753,
-0.008701086,
0.025797723,
-0.0033575564,
-0.0011249973,
-0.0051243417,
0.0050712056,
0.017056786,
0.024628723,
0.0033824642,
-0.008435404,
0.032705456,
-0.00421106,
0.021560095,
0.0070870677,
0.0060143764,
-0.00985016,
-0.01056086,
-0.013051629,
0.012340929,
0.010135769,
0.0068147434,
0.0016854203,
0.0019610652,
0.012985208,
-0.017601432,
0.0032546045,
-0.014971182,
-0.014692215,
-0.01956748,
-0.022104744,
-0.020816186,
-0.028613953,
-0.0184649,
-0.03265232,
-0.0045398413,
-0.00016740042,
-0.019607332,
0.012580044,
-0.003942057,
-0.018451616,
0.0011640193,
-0.007777841,
-0.00900662,
-0.044554874,
0.01882357,
0.019474491,
-0.00074598525,
-0.024097359,
-0.027391816,
-0.01354314,
0.007691494,
0.00842212,
0.02098888,
-0.012852367,
-0.011570452,
0.013244248,
0.013363805,
-0.0019328366,
-0.0507984,
0.003294457,
0.009803666,
0.008362342,
-0.028879635,
-0.01772099,
-0.039985143,
-0.0015434464,
0.0031848631,
-0.0053468505,
0.013656056,
-0.0083556995,
-0.013842032,
0.028667089,
-0.017349035,
0.022370426,
-0.013071555,
0.006994079,
0.006645371,
0.007983744,
-0.024389608,
-0.008926916,
0.005243899,
0.023406586,
0.028321702,
-0.0038391051,
0.022436846,
0.01567524,
0.025611745,
0.006080797,
0.021440538,
0.0369298,
-0.029889226,
-0.0022101423,
0.0139483055,
-0.0011781337,
0.014360113,
-0.005287072,
-0.0073461076,
-0.013171186,
-0.014001442,
0.0052272934,
0.029251589,
-0.010354957,
-0.00023060368,
-0.0059977714,
-0.0158745,
-0.0019511023,
-0.036132753,
-0.0045664096,
0.01266639,
-0.032838296,
-0.007850903,
0.0048420546,
0.008554961,
-0.003191505,
0.00579851,
-0.0062667746,
-0.011344622,
0.026289236,
-0.016937228,
0.027630929,
0.017096637,
0.021878913,
-0.022118028,
0.029145317,
-0.00476235,
-0.016578557,
-0.0015832988,
-0.018132797,
-0.025545325,
-0.003829142,
-0.017481877,
0.0110058775,
0.026156394,
-0.018518036,
0.022343857,
0.0035103236,
0.025027245,
-0.005293714,
-0.023844961,
-0.00738596,
-0.05106408,
0.004094824,
0.02400437,
-0.02569145,
-0.02067006,
-0.0063896524,
-0.016631695,
0.008063449,
-0.023008062,
-0.030314317,
-0.016977081,
-0.0041678865,
0.004064935,
0.0077512725,
0.008800716,
-0.0016364352,
-0.02501396,
-0.005187441,
0.0007978763,
-0.007266403,
-0.005695558,
0.018119514,
0.015250147,
0.01918224,
-0.024562301,
-0.0066719395,
0.005028032,
-0.028135724,
-0.03621246,
-0.010354957,
-0.011490747,
0.019873014,
0.027033145,
-0.021626515,
-0.026422076,
-0.0036896588,
-0.039480347,
-0.004333938,
0.029145317,
-0.015515829,
0.01078669,
0.026063405,
-0.011145361,
-0.015515829,
-0.002231729,
0.016950512,
0.00845533,
-0.0140147265,
0.030765977,
-0.003991872,
0.010441303,
0.016286308,
-0.019261945,
-0.022848653,
0.01668483,
-0.00029308046,
-0.014333544,
-0.0038191788,
-0.01875715,
0.03661098,
-0.0048387335,
0.024602154,
-0.010966025,
0.009690751,
0.0011083921,
-0.03942721,
-0.0038391051,
-0.004742424,
-0.011690008,
-0.043040484,
0.00050230505,
0.0030470407,
-0.00040059866,
-0.0020142018,
-0.027099565,
-0.0077379886,
0.0105143655,
-0.000049996994,
0.0092723025,
0.0041745286,
-0.0033127225,
0.00041263737,
0.0037261902,
0.00082361425,
0.0006957548,
-0.024814699,
-0.024734994,
-0.00686788,
-0.003566781,
-0.0025621708,
0.022689244,
0.009398501,
0.023605846,
-0.035388842,
0.012480413,
-0.006067513,
-0.0009547947,
-0.010633922,
0.009278944,
-0.0031151215,
-0.013470078,
-0.0056125326,
-0.017681139,
-0.007990386,
-0.004456816,
-0.009790382,
0.012653106,
-0.04532535,
0.017694421,
0.008634665,
0.009571195,
-0.013224322,
-0.026408792,
-0.0038922415,
-0.011603662,
0.0050479583,
0.18672131,
-0.026926871,
0.00949149,
0.02864052,
-0.011211781,
0.015409556,
0.01814608,
0.00068371603,
0.027896611,
0.013071555,
0.023991086,
-0.00563578,
-0.001989294,
-0.0006691866,
0.03663755,
-0.013363805,
-0.030154908,
-0.017973388,
-0.005552754,
-0.008149795,
-0.016246455,
-0.003712906,
0.0058483253,
0.010261968,
0.017030217,
-0.0001276519,
-0.0010344994,
-0.010288536,
0.013018418,
0.02089589,
-0.02666119,
0.0045464835,
-0.0020806221,
0.012301077,
0.016352728,
0.005576001,
0.00056166836,
0.00476235,
0.0062966635,
0.009484848,
0.028188862,
-0.012394066,
0.007538727,
-0.0071933405,
-0.0035999913,
0.0335025,
0.018265639,
0.0006758286,
-0.01578151,
-0.0038723154,
-0.03823164,
0.009132819,
-0.008926916,
0.036903232,
0.014094431,
-0.005419913,
-0.0029357863,
0.025346063,
-0.0001987426,
0.047291398,
-0.031669296,
0.007166772,
-0.019687036,
0.059247088,
-0.004722498,
0.010388167,
0.00078251655,
0.0032645678,
0.02938443,
-0.000273777,
0.020789618,
0.010607354,
-0.014811772,
0.011849417,
0.004274159,
0.0005018899,
0.03334309,
0.015422841,
0.022529835,
0.004895191,
0.008953484,
0.0056623477,
-0.021746073,
0.009644257,
-0.023539426,
-0.031111363,
0.016498853,
-0.0047092135,
-0.008548318,
-0.0062402063,
0.009551268,
-0.0158745,
-0.012407349,
0.0007277196,
-0.012673032,
0.0009863444,
0.009757171,
-0.001969368,
-0.01655199,
0.00089916756,
-0.047052283,
0.057227906,
0.031775568,
0.008229501,
0.002166969,
0.0058815354,
-0.010195547,
0.020962311,
-0.015529114,
-0.0001906476,
0.0012138347,
-0.024907688,
0.007764557,
-0.022144595,
0.0033276672,
0.019607332,
0.0038557102,
-0.03456523,
0.03841762,
0.008481898,
-0.008136512,
-0.020444231,
-0.005858288,
0.016366012,
0.006047587,
-0.0018797002,
-0.02546562,
0.01088632,
-0.0071999826,
-0.018783718,
-0.009916581,
-0.0017020254,
0.015622103,
-0.0027647535,
-0.02053722,
0.007950534,
-0.026554916,
0.0069276583,
-0.029251589,
-0.0000030323813,
-0.009836877,
-0.018637594,
0.0010029495,
-0.010919531,
0.016724683,
0.005170836,
0.0014712141,
0.035973344,
0.0057486943,
-0.011643514,
-0.00311014,
-0.012945356,
0.0057486943,
0.0029241627,
0.015250147,
-0.04027739,
-0.01402801,
-0.021799209,
0.010673774,
-0.00809666,
-0.015847933,
-0.00184649,
0.027870042,
0.0077911247,
-0.0067117917,
-0.007000721,
-0.16716713,
0.012653106,
0.020484082,
-0.003294457,
0.0050512794,
0.010833184,
0.029437566,
0.015847933,
-0.008402194,
0.014625794,
0.010607354,
-0.0010909567,
-0.021042015,
-0.027444951,
-0.0026086653,
0.013503288,
0.003862352,
0.041552667,
0.013503288,
0.011032445,
0.020125411,
-0.013390373,
0.018611025,
-0.01970032,
0.0074723065,
-0.0077114203,
-0.01432026,
0.005951277,
0.0071933405,
-0.048858922,
-0.008242784,
0.005712163,
0.010288536,
0.008687802,
0.0073195393,
0.008694444,
-0.000110942994,
0.0075121587,
-0.003978588,
0.016445717,
0.007253119,
0.01726933,
-0.018544605,
-0.0073461076,
-0.018212501,
0.0025090345,
0.0049350434,
-0.0060010925,
-0.0009215845,
-0.0037095852,
0.015701806,
-0.03440582,
-0.017973388,
0.018797003,
0.039480347,
0.0096309725,
0.021971902,
0.032439772,
0.015901068,
0.0050844895,
-0.0036332016,
-0.00981695,
0.010992593,
0.010248683,
-0.0032595862,
-0.033157114,
-0.01616675,
-0.009146104,
-0.01603391,
-0.007239835,
-0.022489982,
-0.00036136905,
-0.018478183,
-0.029756386,
0.02148039,
0.012812515,
0.0054630865,
-0.01801324,
0.0058483253,
0.015861217,
-0.017256046,
0.008933557,
-0.001989294,
-0.025638314,
-0.008342415,
0.003236339,
0.020244969,
0.013988158,
-0.008727654,
0.021785924,
0.010873036,
-0.02436304,
0.017428739,
-0.020563787,
0.033635344,
0.00052555226,
0.0064859623,
0.00083108654,
0.0113977585,
-0.0033127225,
0.004101466,
0.01380218,
-0.033927593,
-0.00065839326,
0.028109157,
-0.018132797,
-0.013881885,
0.019102536,
0.03661098,
0.008933557,
-0.009896655,
-0.0060309814,
-0.0035601389,
0.027444951,
-0.019447923,
0.0028361555,
0.02258297,
-0.0015201992,
0.017601432,
0.004111429,
0.062382136,
-0.018544605,
0.018039808,
0.025372632,
0.017402172,
0.0065291356,
-0.14399965,
-0.024177063,
0.016020626,
0.02296821,
-0.0035501758,
0.007797767,
0.018318774,
0.028135724,
-0.013596277,
0.03334309,
-0.005529507,
0.012500338,
0.0015832988,
-0.02154681,
-0.005708842,
0.010521008,
0.020497367,
-0.003696301,
-0.026767462,
0.02909218,
-0.0064261835,
-0.0029889226,
0.010168979,
-0.0043372586,
-0.0046892874,
0.003042059,
-0.013682623,
0.022941642,
0.0127394525,
0.0122479405,
-0.008402194,
-0.015236863,
-0.00018182612,
-0.00793725,
0.006250169,
-0.014904761,
-0.0051176995,
-0.037408028,
0.014506238,
-0.029331295,
-0.016671546,
0.014293692,
0.01632616,
0.019248663,
-0.013895169,
0.011842775,
-0.0052538617,
0.0031998076,
-0.013576351,
-0.020364527,
-0.02601027,
-0.0046693613,
-0.0014396644,
0.001914571,
0.020869322,
-0.005519544,
0.009438354,
-0.00515091,
-0.025864143,
-0.015661955,
0.013709192,
0.018876707,
-0.005818436,
0.013656056,
0.0071933405,
-0.0054896544,
-0.049682535,
-0.031031659,
0.024920972,
-0.0202184,
-0.00812987,
0.0036132752,
0.0026252703,
-0.008003671,
-0.025864143,
0.0046760035,
-0.015555682,
0.0018182612,
0.02098888,
0.012168236,
-0.018571172,
-0.015090738,
0.017003648,
-0.016060477,
0.007990386,
0.018278923,
0.007405886,
-0.021095151,
-0.009318797,
-0.0073660337,
-0.018212501,
0.015542397,
-0.000374238,
-0.01882357,
-0.018929843,
0.02688702,
0.010261968,
0.00086097576,
0.019421356,
0.0007837619,
-0.025864143,
-0.029703248,
-0.032572616,
-0.011504031,
0.008468614,
0.00095645525,
0.017216194,
-0.024642006,
-0.007777841,
-0.004237628,
0.010315104,
0.00064967555,
-0.009199239,
0.008893705,
-0.010966025,
-0.012042037,
-0.018039808,
-0.025199939,
0.047291398,
-0.016126897,
0.021161573,
0.02245013,
0.018929843,
-0.008329131,
0.016379297,
0.0068944483,
-0.017601432,
0.002510695,
-0.018225785,
0.026116543,
-0.011351264,
-0.01655199,
-0.004619546,
-0.02001914,
-0.0010120824,
-0.001843169,
-0.0007264743,
-0.023898097,
0.0079638185,
0.021533526,
0.013815464,
0.013828749,
-0.035973344,
-0.043332737,
0.003706264,
-0.014466385,
-0.024309903,
-0.022383709,
-0.0040284037,
0.016737966,
-0.002186895,
-0.017681139,
0.032120954,
0.019647185,
-0.0053103194,
-0.0421106,
-0.030898817,
0.002445935,
-0.003379143,
0.0024990714,
0.0012428936,
-0.003712906,
0.056643404,
0.003321025,
0.0018880027,
0.0074656643,
0.00009044605,
-0.019859731,
-0.0074324543,
0.003321025,
0.0065756296,
-0.033954162,
-0.022848653,
0.019102536,
0.033608776,
-0.015768228,
0.005320282,
-0.027630929,
0.0049948217,
-0.021520242,
-0.018066376,
0.028746793,
0.020258253,
0.011802923,
-0.023393301,
0.03424641,
0.035867073,
0.01295864,
-0.013118049,
0.022768948,
-0.0045697307,
0.025571894,
-0.019979287,
0.012971925,
0.013974873,
0.023805108,
-0.0035335708,
0.018836854,
-0.023831677,
0.015927637,
-0.0039852303,
0.016698115,
0.001665494,
0.016153466,
0.026023554,
-0.03560139,
-0.0047125346,
0.013224322,
-0.026249383,
-0.009690751,
-0.014572659,
0.008475256,
-0.0020839432,
-0.03398073,
-0.020457515,
0.009717319,
-0.027630929,
0.020776333,
0.0052140094,
-0.010912889,
-0.0151571585,
0.031988114,
0.02445603,
0.0054962966,
0.003168258,
-0.003553497,
0.016180035,
0.00816308,
0.024761563,
-0.020949027,
0.028985908,
0.0031665976,
0.02193205,
-0.008634665,
-0.013828749,
-0.0019544233,
0.0010162337,
-0.012088532,
0.015382988,
0.02193205,
-0.013450152,
0.0801297,
-0.0013707532,
-0.03828478,
0.0009921562,
-0.016777819,
0.0077313464,
0.0055029388,
0.004682645,
-0.015396273,
-0.023340164,
0.021892197,
-0.010056064,
0.037540868,
-0.021201424,
-0.02199847,
0.009159387,
-0.017083352,
0.029039044,
-0.027232407,
-0.02879993,
0.017149774,
-0.027949747,
0.013895169,
0.004064935,
-0.005549433,
-0.0059844875,
0.013224322,
-0.010667133,
0.011670082,
-0.00955791,
0.017030217,
-0.009883371,
-0.045139372,
-0.013589635,
-0.023273744,
-0.005034674,
-0.00046992506,
-0.019195525,
-0.03148332,
0.008256068,
0.018425047,
0.010102559,
-0.005688916,
-0.029065613,
-0.01623317,
0.0034472242,
-0.03738146,
-0.01801324,
-0.015210295
] |
Birds are difficult to sex. Nestlings rarely show sex-linked morphology and we estimate that adult females appear identical to males in over 50% of the world's bird species. This problem can hinder both evolutionary studies and human-assisted breeding of birds. DNA-based sex identification provides a solution. We describe a test based on two conserved CHD (chromo-helicase-DNA-binding) genes that are located on the avian sex chromosomes of all birds, with the possible exception of the ratites (ostriches, etc.; Struthioniformes). The CHD-W gene is located on the W chromosome; | [
-0.03106038,
-0.0007360182,
-0.012475612,
-0.022180332,
0.005225111,
-0.003118903,
-0.009605759,
0.003191474,
-0.03541464,
-0.012640546,
-0.028949225,
0.011439825,
-0.005594563,
0.024647744,
-0.0151343485,
0.018221915,
0.028447825,
0.0027164638,
0.0155038005,
-0.026745705,
-0.04744823,
0.01888165,
0.0033481612,
-0.03206318,
-0.023644947,
0.014619755,
0.009671733,
-0.020913638,
-0.0325118,
0.0055384855,
0.012495404,
0.012132549,
-0.012251302,
-0.0535178,
-0.027920036,
0.000054067445,
0.012785688,
-0.017008,
0.022470616,
-0.017839268,
0.032775696,
0.0076001612,
-0.014817676,
-0.025848465,
-0.013214516,
0.017311478,
-0.0050931633,
-0.009414435,
-0.01015334,
0.006815075,
-0.0017598463,
0.0108724525,
-0.031746507,
-0.0035493807,
-0.017271893,
0.010113756,
0.014250302,
0.02058377,
0.021810878,
-0.019343466,
-0.021969216,
-0.009638746,
-0.026772095,
0.016862858,
-0.017483009,
-0.0074616163,
0.006267494,
-0.0014646144,
0.018010799,
0.030427033,
0.028395046,
0.0032310581,
0.005172332,
0.018723313,
0.021045584,
-0.018921234,
-0.02243103,
-0.019844865,
-0.012686728,
-0.010839466,
0.029477013,
-0.034095168,
0.006646842,
0.023790088,
0.012541586,
0.0027230612,
-0.0010555779,
0.016308678,
0.014751702,
0.003433927,
0.0027725415,
0.007943224,
-0.002658737,
-0.0009005399,
-0.014962818,
-0.011241905,
0.014237108,
0.01966014,
-0.003704419,
-0.029160341,
-0.018815676,
-0.006887646,
-0.004839165,
-0.0043575577,
-0.014144745,
-0.012007199,
0.0058452627,
-0.025597764,
0.025215117,
-0.018327473,
-0.0055351867,
0.013986408,
0.00812795,
-0.031113159,
0.046709325,
-0.03631188,
-0.010245703,
-0.004974411,
-0.015926031,
0.023592167,
0.04166894,
-0.004736906,
0.0038033791,
-0.02033307,
0.012244704,
0.016361458,
-0.023275493,
-0.008299481,
-0.0024047385,
-0.0035328874,
0.022351863,
-0.0109780105,
0.012620754,
0.021481011,
-0.044255104,
-0.012996803,
-0.015569774,
0.006320273,
0.0052284095,
-0.021388648,
-0.0087546995,
0.025848465,
-0.014738507,
-0.021124754,
0.016651742,
0.010410638,
0.007540785,
-0.0051789293,
0.0052185133,
0.008959218,
0.006597362,
0.021744905,
0.049216323,
0.0075803692,
0.014791286,
0.043014802,
-0.00066014857,
0.0054857065,
0.007804679,
-0.012337067,
-0.02681168,
0.020491406,
0.0036219517,
-0.0074220323,
0.021573374,
0.014685728,
-0.018604562,
-0.014540586,
-0.0033267199,
-0.00004386215,
-0.008319274,
0.010298482,
-0.022272695,
0.019396244,
0.017944824,
0.019198325,
-0.00024080371,
0.010344664,
-0.024449823,
-0.024726912,
-0.016625352,
0.012647143,
0.025254702,
-0.005347162,
-0.021335868,
0.013194724,
0.0021227011,
-0.024581771,
-0.0008642544,
-0.0070987614,
0.01192803,
-0.0152399065,
0.017694125,
-0.0071515404,
-0.63630235,
0.010470013,
0.0087151155,
-0.008094964,
0.02580888,
0.021507401,
0.014091966,
0.014962818,
0.0036549387,
0.027920036,
0.0068216724,
-0.006834867,
-0.0041827275,
0.0040738713,
-0.03449101,
-0.03868693,
0.011215515,
-0.026323475,
0.02731308,
0.018762898,
-0.011525592,
0.011334268,
0.0074946033,
0.010311677,
-0.0076397453,
0.0030314878,
0.018525392,
-0.01787885,
0.017245505,
0.017456621,
-0.011723513,
0.024014398,
-0.009447423,
0.0065313885,
0.0377633,
0.002096312,
-0.0071647353,
0.019369856,
0.018129552,
0.026244307,
-0.002658737,
0.011670734,
0.004387246,
0.00302654,
-0.0033118757,
0.0043641552,
0.0048160744,
0.0072175143,
0.015688527,
-0.0152794905,
-0.008490805,
-0.0066732317,
-0.0027741909,
-0.015662137,
-0.01888165,
-0.001618003,
0.022826873,
-0.038581375,
0.014659339,
0.005406538,
-0.019897643,
0.011776291,
0.014659339,
-0.007481409,
-0.0028451125,
0.031667337,
-0.009064776,
-0.0024195826,
-0.0017697423,
-0.01765454,
0.005871652,
0.031984013,
-0.008286287,
0.0023915437,
0.027049184,
0.037235513,
0.012719714,
0.0026537888,
-0.019224713,
0.011136347,
-0.0038396646,
-0.0065346872,
-0.004252,
0.012475612,
0.018749703,
-0.020953221,
-0.009506798,
0.022351863,
0.008490805,
-0.0052712923,
0.026560979,
0.0064093373,
0.0014398743,
-0.0019214817,
-0.0045950627,
0.0151607385,
0.008240106,
-0.01192803,
0.011525592,
-0.037842467,
-0.019792086,
0.0046676337,
-0.0020732211,
-0.00036203023,
0.008998802,
0.017245505,
-0.02123031,
0.0014910038,
0.03581048,
0.01580728,
-0.0151079595,
-0.0267589,
-0.008616155,
0.0035559782,
-0.024713717,
-0.018472614,
0.0131617375,
0.017852461,
0.011222113,
-0.02123031,
0.009302281,
-0.003066124,
-0.014923233,
-0.022444226,
0.022747705,
-0.0059409244,
-0.026112359,
-0.014091966,
0.01052939,
-0.019580971,
0.0056407447,
0.0024393746,
0.007897043,
-0.0154246325,
0.010456819,
0.030110361,
0.012917635,
0.008820673,
0.0002148266,
-0.0058815484,
-0.009843264,
0.021045584,
0.0058056787,
-0.009955419,
-0.014184329,
-0.004611556,
-0.012020393,
-0.022945626,
-0.011010997,
-0.005957418,
-0.0109780105,
-0.024819275,
-0.025267897,
0.0069272304,
0.0021012598,
-0.0072043194,
0.0012625701,
-0.018512199,
0.011763097,
-0.02488525,
0.0077519002,
0.0072570983,
-0.025742907,
-0.0330132,
-0.009196723,
-0.008444623,
0.0055879657,
0.02828949,
-0.022694925,
-0.03317154,
0.0086491415,
-0.0087019205,
-0.021045584,
0.008286287,
0.027920036,
-0.008616155,
0.0011726811,
-0.0043641552,
-0.016849663,
-0.025531791,
-0.0022018696,
-0.022061579,
-0.043225918,
-0.02580888,
0.027920036,
0.020504601,
0.03435906,
0.012693325,
0.0008667284,
0.02055738,
-0.011241905,
-0.01195442,
-0.01052939,
0.009737707,
0.031297885,
-0.0151079595,
0.033699326,
0.025201922,
-0.0051261503,
0.03208957,
0.02821032,
-0.007283488,
-0.0053966423,
-0.01185546,
0.011189126,
-0.022628952,
0.0027510999,
-0.010206119,
-0.007943224,
0.0075869663,
0.00023276318,
-0.002465764,
0.006000301,
-0.0032722915,
-0.0023074273,
0.005634147,
-0.01578089,
0.0037967819,
0.014619755,
0.018367056,
-0.00882727,
-0.0010984608,
0.025069976,
0.010733908,
0.0024162838,
0.0061586373,
0.0015495555,
0.0065511805,
0.011367255,
-0.016137147,
-0.004644543,
0.010245703,
-0.010549182,
0.002290934,
0.014289887,
0.004538985,
0.000613967,
0.0018621054,
0.01918513,
-0.0011867005,
0.02128309,
-0.010371054,
0.012442625,
-0.017614957,
0.029133951,
-0.008635947,
0.020662937,
0.016493404,
-0.009559577,
0.0087283105,
0.006382948,
-0.014764897,
-0.0051030596,
0.0038000806,
0.015622553,
-0.01765454,
0.021151142,
-0.0033250705,
0.018287888,
0.00827969,
0.027075574,
-0.009368254,
0.009665135,
-0.0052515003,
-0.00026080196,
0.0042585973,
0.010219314,
-0.0077387057,
-0.0034042387,
-0.013762097,
-0.0020748703,
0.02016154,
-0.0036219517,
-0.014316276,
0.013762097,
0.004654439,
-0.0047599967,
0.0014860558,
0.014435029,
0.011010997,
-0.009275891,
-0.026719317,
0.02683807,
0.041431434,
-0.018947624,
-0.021520594,
-0.0013334918,
-0.0022991807,
-0.008536986,
0.031192327,
-0.0019676632,
0.010951621,
0.017390646,
0.005258098,
-0.004750101,
-0.014118355,
0.016612157,
-0.0154642165,
0.022008799,
-0.005258098,
0.010958218,
0.019053182,
-0.02108517,
0.009368254,
0.016796883,
0.0172587,
-0.014989207,
0.0073296693,
0.006689725,
-0.013550982,
-0.0107537005,
-0.030057581,
-0.012462417,
0.00020946625,
-0.014896844,
0.011486007,
-0.021692127,
0.0010992854,
-0.00039233686,
0.011789486,
-0.036654945,
-0.025888048,
-0.01658577,
0.008893244,
0.046075977,
0.013465216,
-0.020293485,
0.01578089,
-0.008075171,
0.010219314,
0.00008999214,
-0.0028170736,
0.016321873,
0.009407838,
0.010456819,
0.006475311,
0.010760297,
0.01217873,
-0.0038198726,
0.019171935,
-0.005521992,
-0.036021598,
-0.010562377,
0.022035189,
-0.025347065,
0.010588766,
0.0034108362,
0.034702126,
0.02466094,
-0.012007199,
0.01182907,
0.019871255,
0.0039848066,
-0.024819275,
-0.026666537,
0.009526591,
-0.0021771295,
0.01935666,
0.0032821877,
0.0024261798,
0.0023915437,
0.005429629,
0.0036780294,
-0.00862935,
0.022180332,
0.007230709,
0.0019297284,
0.011716915,
-0.003433927,
0.013814876,
0.035150744,
0.009421033,
-0.012409638,
-0.029503403,
0.0037769899,
-0.013465216,
-0.016335068,
-0.017324673,
0.009585967,
-0.004047482,
-0.0070987614,
0.006755699,
0.017126752,
-0.00014297721,
-0.025241507,
-0.01985806,
0.009143944,
0.002411336,
-0.007804679,
-0.01078009,
-0.012231509,
-0.0033877455,
-0.04845103,
-0.0129242325,
0.0054494212,
-0.027603364,
-0.011274892,
-0.019950423,
0.007857459,
0.011631149,
0.016123952,
0.0071845273,
0.007065775,
0.0217581,
0.001157837,
-0.017298283,
0.015622553,
-0.014144745,
-0.01793163,
0.02518873,
0.0021655841,
-0.012172133,
-0.009440825,
0.011815876,
0.009546383,
-0.0077255107,
-0.0070063984,
-0.021520594,
0.007989406,
0.043938432,
0.020293485,
0.04868853,
0.0077057187,
-0.01717953,
-0.0031832273,
-0.018261498,
-0.010318275,
-0.022391446,
-0.021019196,
0.00037357563,
-0.015622553,
0.026006801,
-0.02030668,
-0.0007854984,
-0.00019864245,
-0.02921312,
0.015886448,
0.015978811,
0.0077321082,
0.0152003225,
-0.0023849464,
0.021969216,
-0.011947823,
-0.012673533,
0.024001203,
-0.019778892,
0.026204722,
0.026297085,
-0.044043988,
0.014448223,
-0.014844065,
-0.021217117,
-0.025043586,
0.00730328,
0.02035946,
0.026349865,
-0.00019987945,
-0.028500604,
-0.0026224514,
0.002368453,
-0.004047482,
0.0061718323,
-0.02683807,
-0.015121154,
0.011222113,
0.016876053,
0.022892846,
-0.035150744,
0.0064489213,
-0.027445026,
-0.027392248,
0.020530991,
-0.0011256749,
0.020662937,
-0.01653299,
0.005225111,
0.015926031,
-0.017575372,
0.0036120557,
-0.0151475435,
0.009071372,
0.00033151745,
0.027550584,
0.01365654,
0.029529793,
-0.021019196,
0.025756102,
0.0287645,
0.020530991,
-0.013722513,
-0.016968416,
0.0005752075,
-0.020240707,
0.039768897,
0.013775292,
0.017614957,
-0.016071174,
-0.0012403041,
0.014580171,
0.015978811,
-0.017535789,
-0.023974814,
-0.003268993,
-0.058531795,
-0.022853263,
-0.021626152,
-0.0064489213,
-0.0042256103,
-0.03966334,
0.009638746,
0.03768413,
-0.011327671,
0.0053075776,
-0.020069176,
0.03823831,
0.0022150644,
0.018723313,
-0.010285287,
0.003559277,
-0.02055738,
-0.0047303084,
-0.01460656,
0.017469814,
0.0345174,
-0.01508157,
0.015899643,
0.0068942434,
-0.0110571785,
0.0002834804,
0.00682827,
-0.016849663,
0.00382647,
-0.0067062187,
-0.006537986,
-0.016467016,
-0.034834072,
-0.034966018,
-0.036971617,
0.012746103,
0.010133548,
-0.015965616,
0.01122871,
0.018050382,
-0.0076199532,
-0.004314675,
-0.0031073575,
0.029793687,
-0.029793687,
0.054784495,
0.006237806,
-0.0058683534,
-0.033884052,
0.0075275903,
0.0060134954,
0.033567376,
0.020029591,
0.0133728525,
0.001758197,
-0.020095564,
-0.004746802,
0.018644145,
-0.021890048,
-0.023473414,
0.003414135,
-0.014369055,
-0.00765294,
0.003704419,
-0.0011240256,
-0.0029605662,
-0.0022002202,
-0.0077716927,
0.0047632954,
-0.0020897144,
-0.0037967819,
0.003938625,
0.013320074,
-0.015569774,
0.009302281,
0.005907938,
0.0050106966,
0.014883649,
-0.020596964,
-0.016189927,
0.0087151155,
0.03153539,
0.031297885,
-0.012594365,
-0.017271893,
0.018604562,
0.010588766,
-0.0152794905,
-0.0045752707,
0.0010209418,
0.03206318,
-0.029107561,
0.0015173933,
-0.03736746,
-0.0047237114,
-0.0066534397,
0.025056781,
-0.01966014,
-0.0227609,
-0.02530748,
-0.014896844,
0.021969216,
-0.011340865,
0.004964515,
-0.0153586585,
-0.03216874,
0.012812077,
-0.055365063,
-0.039795287,
0.020715717,
-0.026468616,
0.0011974212,
0.00860296,
-0.007012996,
0.019013597,
0.029899245,
-0.00023132001,
0.009447423,
0.03823831,
-0.0032327075,
0.026046386,
0.0034108362,
0.0155038005,
-0.034939628,
0.004011196,
0.005832068,
-0.027445026,
-0.013775292,
-0.022365058,
0.0063037793,
0.0039848066,
0.0153322695,
0.012752701,
0.022299083,
-0.011697123,
0.00945402,
0.00085518305,
0.037050784,
-0.010773492,
-0.02631028,
0.03016314,
-0.012508598,
-0.007930029,
0.0013483359,
0.015041986,
0.0040606763,
-0.007956418,
0.0064885058,
0.015846863,
-0.0015322374,
-0.023156742,
-0.031271495,
0.002906138,
0.005832068,
-0.015635747,
-0.026917238,
-0.012112757,
-0.028315878,
0.0068216724,
-0.021032391,
-0.0109648155,
0.013023193,
0.013537787,
-0.012191925,
0.017377451,
-0.009308878,
0.00064365513,
-0.013907239,
-0.009374851,
-0.05404559,
-0.006524791,
0.0032953823,
0.036047988,
0.030268697,
-0.0022167137,
-0.027049184,
-0.009256099,
-0.031271495,
-0.006980009,
-0.005749601,
0.0076991217,
0.0006820023,
0.031667337,
-0.01340584,
0.012086367,
0.009823472,
0.020214317,
-0.0212567,
-0.013696124,
0.032749306,
0.009612356,
0.028368657,
0.029608961,
-0.02295882,
-0.016572574,
0.026574174,
-0.018512199,
-0.012119354,
0.019119155,
-0.018037189,
0.028051984,
-0.007672732,
0.012891245,
0.0036483412,
0.00835226,
0.0027857362,
-0.020900443,
-0.03837026,
0.0028451125,
-0.004878749,
-0.024199124,
0.0002142081,
-0.02008237,
0.0005455194,
0.014171134,
-0.057159547,
-0.0157545,
0.013174932,
-0.006646842,
0.0010159938,
0.018327473,
-0.004644543,
0.0165066,
0.011914836,
0.011545383,
-0.0130429845,
-0.017839268,
-0.027840868,
-0.009236307,
-0.026798485,
-0.019422634,
-0.016374653,
-0.024093566,
0.009876251,
-0.015477411,
0.011683928,
-0.015701722,
-0.022945626,
-0.008081769,
0.031245107,
-0.012851661,
-0.0011743305,
-0.0021804282,
0.02923951,
0.0025845165,
0.003333317,
-0.007943224,
-0.025465818,
-0.022365058,
0.011241905,
0.0034273297,
-0.015345464,
-0.032854863,
0.022668537,
0.0050733713,
-0.022114357,
0.0021738308,
0.18989848,
-0.010008198,
0.0070063984,
0.011083568,
-0.00230083,
-0.01135406,
0.0152794905,
0.014012797,
0.008946023,
-0.011697123,
-0.00049356517,
0.03248541,
-0.032247905,
0.013049582,
0.028579773,
-0.031931233,
0.0016303731,
-0.026085969,
0.002340414,
0.0019511698,
-0.0039881053,
-0.011624552,
-0.011895044,
-0.03253819,
0.026521396,
0.00036120557,
-0.029081171,
-0.016625352,
-0.026099164,
-0.00417613,
-0.034279894,
-0.012587767,
0.0049975016,
-0.0130297905,
-0.008061976,
-0.0130034005,
0.011334268,
0.023539389,
-0.004314675,
0.012818675,
0.023922035,
0.0152531015,
0.040956423,
0.005096462,
0.01062835,
0.013788487,
0.009962017,
-0.006000301,
-0.0050535793,
-0.011749902,
-0.019475413,
0.018287888,
0.016796883,
0.0075473823,
-0.016836468,
-0.014118355,
0.015978811,
-0.018169135,
-0.011934628,
0.02413315,
-0.011591565,
0.0027890347,
-0.020095564,
0.019277493,
-0.019646944,
0.049612164,
-0.02566374,
0.00010638246,
0.012026991,
-0.0039353264,
0.026072774,
-0.0335146,
-0.010819674,
-0.0016881,
0.0006997327,
-0.013722513,
0.021481011,
0.009308878,
0.021810878,
0.019739307,
-0.0001766856,
0.007949822,
-0.030321477,
-0.0076661347,
-0.026732512,
-0.0152926855,
0.034227114,
0.0018010798,
-0.0073164743,
-0.01608437,
-0.0076793293,
-0.0031551884,
-0.00091950735,
0.0001614292,
0.026640149,
0.029450625,
0.010173133,
0.018169135,
-0.010285287,
-0.01673091,
-0.016889246,
0.035968818,
0.0075671743,
0.026165137,
0.0087151155,
0.014725313,
-0.0153190745,
0.011782888,
0.005472512,
-0.020662937,
-0.005739705,
-0.031878453,
0.012798882,
-0.0015998603,
0.006775491,
0.011255099,
0.030902043,
-0.04217034,
0.013748903,
0.0028137749,
0.019449024,
-0.036127154,
0.005746302,
0.037842467,
0.008411637,
-0.016744105,
-0.005690225,
-0.0071713324,
0.005297682,
-0.030295087,
-0.008345663,
-0.008002601,
-0.0039122356,
0.0042783893,
0.0025416338,
-0.010707519,
0.005337266,
-0.022127552,
-0.01930388,
0.003836366,
-0.0010951621,
-0.004588465,
0.020095564,
0.019897643,
0.034174334,
-0.03581048,
-0.0021870255,
-0.0086227525,
-0.0070723724,
-0.0027692427,
-0.036047988,
-0.0063565583,
0.013973213,
-0.0010423833,
0.008180729,
-0.018934429,
0.008860257,
-0.014329471,
-0.00039749107,
-0.005241604,
0.007930029,
0.007158138,
0.042328674,
-0.011083568,
-0.0036120557,
-0.0152794905,
-0.16540906,
0.018103162,
0.020148344,
-0.034834072,
0.018103162,
0.03346182,
0.027022796,
0.012277691,
0.011598162,
0.006524791,
0.00942763,
0.009909238,
-0.028104762,
-0.035150744,
0.0004506823,
0.017166337,
-0.018499004,
0.02516234,
0.0130297905,
0.0017186129,
0.004862256,
-0.035229914,
0.02013515,
-0.0019198323,
0.0025267897,
0.0007718914,
-0.010417235,
-0.0153718535,
-0.027049184,
-0.028447825,
-0.010733908,
0.018987209,
0.0154114375,
-0.02513595,
-0.0036087572,
0.003171682,
0.006349961,
-0.015041986,
-0.010357859,
0.012633949,
0.011030789,
0.02013515,
0.017997604,
-0.015833668,
0.020227512,
0.004750101,
-0.012600961,
-0.00920332,
0.013194724,
-0.029582571,
0.019343466,
0.0029176835,
0.026006801,
-0.0023915437,
0.019053182,
-0.0043311683,
-0.02918673,
0.036575776,
0.007356059,
-0.026191527,
0.0061190533,
-0.013491605,
0.025888048,
-0.0010283638,
0.0050865663,
-0.017826073,
-0.024146345,
0.006382948,
-0.02873811,
0.007883848,
0.013036387,
0.0021771295,
0.0036252504,
-0.018248303,
0.019594165,
0.0207553,
-0.028632551,
0.01363015,
-0.004631348,
-0.015385048,
-0.0068018804,
0.012139146,
-0.026006801,
-0.007857459,
0.00320137,
0.00032821877,
-0.0016386198,
-0.0025119456,
0.005149241,
0.021177532,
0.035599366,
-0.031218717,
0.009744304,
-0.002403089,
0.023618557,
0.0056473417,
0.011598162,
-0.022101162,
0.017100362,
0.013933629,
0.0066534397,
-0.012792285,
-0.010997803,
0.03016314,
0.04019113,
0.0074946033,
-0.010568974,
0.0053735515,
0.035256304,
0.020768495,
0.008398442,
-0.0003247139,
0.006000301,
0.018842066,
-0.003056228,
0.0357577,
-0.0059706126,
-0.009777291,
0.013801682,
-0.03958417,
0.07341544,
0.025492206,
-0.013577371,
0.00907797,
-0.003443823,
-0.0038099766,
-0.13511397,
-0.022378253,
-0.002485556,
0.016902441,
-0.020240707,
0.019567776,
0.0011677331,
0.04016474,
-0.014342665,
0.028315878,
-0.010186327,
-0.00071292743,
-0.0022777393,
-0.0018884949,
0.018987209,
0.009981809,
-0.029608961,
-0.010714116,
0.002881398,
0.027999206,
0.008424832,
-0.009249502,
-0.020121954,
-0.020874053,
-0.015939226,
0.012495404,
-0.049084373,
0.029054783,
0.023447026,
0.008550181,
-0.026706122,
-0.011499202,
-0.0071317484,
0.004862256,
-0.04441344,
-0.01553019,
-0.013036387,
-0.039557785,
0.033356264,
-0.005040385,
-0.0018967416,
0.016071174,
-0.00067416794,
-0.016876053,
0.033752106,
0.005746302,
0.016467016,
-0.006465415,
0.0007417909,
-0.019317076,
-0.025690127,
-0.0130957635,
-0.023275493,
0.0066039595,
0.012561377,
-0.013524592,
-0.004139845,
-0.010865855,
-0.02287965,
-0.00965194,
0.000907962,
0.03346182,
-0.004139845,
0.001690574,
0.012436028,
-0.02518873,
-0.027946426,
-0.0024542187,
0.02393523,
-0.0497705,
-0.008081769,
0.012818675,
-0.012957219,
-0.006920633,
-0.03061176,
0.021692127,
-0.020148344,
0.0087019205,
0.0130165955,
-0.005261396,
0.0038132754,
-0.03544103,
0.039953623,
-0.02240464,
0.011037387,
0.002330518,
-0.000686538,
0.0007846737,
0.013577371,
-0.024674134,
-0.019937228,
0.036021598,
-0.016189927,
-0.03404239,
-0.023341468,
0.028395046,
-0.017628152,
-0.030347865,
0.031904843,
0.02028029,
-0.019580971,
-0.010588766,
-0.052805286,
0.025703322,
-0.0017994305,
-0.0035427834,
-0.0010184678,
-0.013346463,
0.0026999705,
0.0075341873,
0.014580171,
0.02178449,
-0.00019915786,
-0.0022810379,
-0.027339468,
-0.0025201924,
-0.0077519002,
-0.0010102211,
0.008180729,
0.012746103,
0.028579773,
0.012297483,
0.007930029,
-0.00717793,
0.036047988,
0.026204722,
-0.010747103,
-0.020214317,
-0.006287286,
0.004242104,
0.0018917936,
0.004756698,
0.021850463,
-0.034016,
-0.018076772,
-0.0019082869,
0.020478211,
-0.0011875252,
-0.008787686,
0.0038990409,
0.005871652,
0.018076772,
0.009018594,
-0.04457178,
-0.0054692132,
-0.013616955,
-0.008240106,
0.014844065,
-0.01340584,
0.020794885,
0.031245107,
-0.009308878,
0.015569774,
-0.0020303382,
0.0052679935,
-0.016796883,
-0.019435829,
-0.013537787,
-0.012436028,
-0.016651742,
0.023578972,
0.0029523196,
0.026772095,
0.035942428,
0.028553383,
-0.008576571,
0.006340065,
-0.0031568378,
-0.0049183336,
0.016044784,
-0.0007050931,
-0.025320675,
-0.036945228,
0.011961018,
-0.004799581,
0.007520993,
0.0019594165,
-0.018050382,
-0.005874951,
0.015028791,
-0.0153718535,
0.008721713,
-0.012548183,
0.025465818,
-0.031403445,
0.013234308,
0.023103962,
-0.004664335,
-0.016123952,
0.009295683,
0.003424031,
0.003191474,
-0.01365654,
0.011169334,
0.00932867,
0.009704719,
-0.005967314,
0.0073824483,
-0.017918436,
-0.0051558386,
0.00057933084,
0.018010799,
0.009572772,
0.0016798533,
-0.0131089585,
-0.02028029,
-0.01603159,
0.015068375,
0.026521396,
-0.02245742,
0.00020410589,
0.0022002202,
0.020399043,
-0.0013425632,
-0.016361458,
0.013946824,
-0.0049414244,
-0.014844065,
-0.0016889247,
-0.004519193,
-0.031825673,
0.026917238,
0.0055054985,
0.03773691,
-0.0002777077,
0.021837268,
0.012172133,
0.01658577,
0.02433107,
-0.00965194,
0.010991205,
-0.015794085,
0.01835386,
0.0040606763,
-0.023539389,
0.0157545,
0.009724512,
0.0068546594,
0.017628152,
-0.00017328384,
-0.021810878,
0.06713475,
0.02243103,
-0.022153942,
0.007883848,
-0.036654945,
0.03240624,
0.0086887255,
-0.017153142,
-0.014514197,
-0.020953221,
0.0030826174,
-0.029556181,
0.018551782,
0.0036384452,
-0.02295882,
0.004535686,
-0.048635755,
-0.008325871,
-0.019950423,
-0.03354099,
0.002629049,
-0.02390884,
0.030268697,
0.007375851,
-0.012310677,
0.011241905,
0.010311677,
-0.008160937,
-0.018433029,
0.026706122,
0.012383249,
0.0051954226,
-0.034622956,
-0.0066138553,
-0.0087151155,
0.010463417,
-0.002485556,
-0.010344664,
0.037156343,
0.0033696026,
0.01933027,
-0.006775491,
-0.012092965,
-0.0016674832,
0.011789486,
0.010674532,
-0.00038986286,
-0.024304682,
-0.004252
] |
Precursor cells of the embryonic cortex sequentially generate neurons and then glial cells, but the mechanisms regulating this neurogenic-to-gliogenic transition are unclear. Using cortical precursor cultures, which temporally mimic this in vivo differentiation pattern, we demonstrate that cortical neurons synthesize and secrete the neurotrophic cytokine cardiotrophin-1, which activates the gp130-JAK-STAT pathway and is essential for the timed genesis of astrocytes in vitro. Our data indicate that a similar phenomenon also occurs in vivo. In utero electroporation of neurotrophic cytokines in the environment of embryonic cortical precursors causes | [
-0.016564645,
-0.012939863,
-0.0043234127,
-0.03361529,
-0.005157045,
0.015862638,
-0.013560868,
0.008653576,
-0.028404247,
-0.027175736,
0.028134245,
0.00093235186,
-0.0061560534,
0.0066285576,
-0.010226339,
0.0059366766,
0.029646259,
0.008511824,
-0.005538423,
0.049140427,
-0.022747697,
0.037719328,
-0.004826292,
-0.017023647,
0.0052110455,
0.006459806,
-0.006979561,
-0.022045692,
-0.0064024306,
-0.0150796315,
-0.013533868,
0.011326599,
0.007620816,
-0.012993863,
-0.0029227755,
-0.00006180522,
0.015336134,
-0.010536842,
-0.0017786404,
0.025555722,
0.014782629,
-0.0050085434,
-0.014337124,
-0.006675808,
0.004326788,
0.018886665,
0.00054717663,
-0.004488789,
0.003803658,
0.02412471,
0.040581353,
0.016443143,
-0.0061628036,
-0.0005340984,
-0.02643323,
-0.005025419,
0.0054979227,
0.016672645,
0.019683171,
-0.022437194,
-0.0051469197,
-0.0058860513,
-0.0153901335,
0.031806275,
0.004009535,
0.021181684,
-0.00634843,
0.018103657,
0.0046541654,
-0.014364125,
0.028026244,
0.014404626,
-0.016483644,
-0.030834269,
-0.004620415,
-0.0067466837,
-0.030726267,
-0.031644274,
-0.0085658245,
0.017536653,
0.0057139248,
-0.033075288,
-0.01845466,
0.029349254,
0.0035471558,
-0.0049984185,
-0.019359168,
0.009409582,
0.0046271654,
-0.006527307,
0.02054718,
0.034965303,
0.017010149,
0.0114886,
0.003098277,
0.013864621,
-0.01934567,
0.048951425,
-0.012359357,
-0.023976209,
-0.011259098,
0.0015204507,
-0.011799103,
-0.029295254,
-0.029160254,
0.011724852,
0.016510643,
0.004036535,
0.03553231,
-0.008761576,
0.0027928369,
0.02538022,
-0.008606325,
-0.041526362,
0.016848147,
0.0014183561,
0.026743732,
0.023517204,
-0.0075533157,
-0.0046507902,
0.01853566,
0.016564645,
0.024529714,
-0.027837243,
0.017050648,
0.023773707,
0.0032670284,
0.0051165447,
-0.020398678,
0.006230304,
-0.0050794194,
-0.013216615,
0.0008146477,
0.036261316,
-0.009760585,
0.015835637,
-0.0015491385,
0.008673825,
-0.007911068,
-0.03906934,
-0.0029464005,
0.011873353,
-0.007857068,
0.011758602,
-0.0057173,
0.028458247,
0.007134812,
0.024462212,
0.025758224,
0.0081135705,
0.013506868,
-0.0070335614,
0.02978126,
-0.024934717,
-0.0025397097,
0.020776682,
-0.014256124,
0.04136436,
-0.017482651,
0.0010977283,
0.0142021235,
-0.013513617,
0.016416144,
0.0009914149,
0.0228827,
0.016537644,
0.016483644,
0.0043099127,
0.032238282,
-0.013587868,
-0.0035066556,
0.013527118,
-0.031806275,
0.02870125,
-0.012123105,
0.009645834,
0.0046507902,
0.014526126,
-0.031752277,
-0.013716119,
-0.007560066,
0.020344676,
0.0040736604,
0.005292046,
-0.006068303,
-0.024354212,
0.04125636,
-0.016227141,
-0.006081803,
0.0034475925,
-0.026014727,
0.01601114,
-0.011097097,
-0.009909086,
-0.6281335,
-0.020871181,
0.034776304,
-0.021586688,
0.0019676422,
0.03331829,
-0.015781637,
-0.014445126,
-0.017320652,
0.015322633,
-0.023301203,
0.00924083,
0.018103657,
-0.0091058295,
-0.001780328,
-0.016942648,
-0.012487609,
-0.004023035,
0.017064149,
0.0068378095,
-0.014377625,
-0.006669058,
-0.016443143,
0.01934567,
-0.0015736074,
0.04357838,
0.0229232,
-0.017914657,
-0.014269624,
0.025515221,
-0.01609214,
0.003400342,
0.00017402496,
-0.017010149,
0.045198392,
-0.0011238848,
-0.028809251,
0.032940287,
-0.021546187,
0.04816842,
-0.0343443,
-0.022680197,
0.00011116503,
-0.0031691527,
-0.020209676,
0.0105773425,
0.0028654,
-0.007202313,
-0.0018410785,
-0.005524923,
0.022518195,
0.0071618124,
-0.019399669,
0.00016569285,
0.002242707,
0.0012917925,
0.007020061,
-0.0019997049,
0.004860042,
0.003577531,
-0.007256313,
0.019116167,
-0.012777861,
-0.010813594,
0.008606325,
-0.003147215,
-0.02192419,
-0.017469153,
0.0027067736,
-0.0088493265,
0.00924083,
0.032238282,
-0.007715317,
-0.0014495751,
0.004151286,
0.018643662,
-0.012582109,
0.0022781447,
-0.010752844,
0.020358177,
-0.01609214,
-0.017118149,
-0.037017323,
0.022126693,
-0.00020070878,
-0.021289686,
-0.027013736,
0.022963699,
-0.005376422,
0.016416144,
-0.0049646683,
0.0026628983,
-0.017617654,
-0.05186745,
-0.021951191,
0.0147691285,
-0.0038137832,
0.012521359,
0.008633325,
-0.02870125,
0.004363913,
0.0061526787,
0.0142021235,
0.010941845,
0.019075666,
-0.0036079064,
-0.042876374,
-0.0010158839,
0.049842432,
-0.050220437,
-0.012136606,
0.0041951616,
-0.0037631576,
-0.022369694,
0.019251168,
-0.01728015,
0.0056565492,
0.0011449787,
-0.012372858,
-0.0071483124,
0.010766343,
-0.024907717,
0.0069998107,
0.011009346,
0.01377012,
0.0043976633,
0.00037842517,
-0.0044955392,
-0.005960302,
-0.0003748392,
-0.009429832,
-0.0077288174,
0.027175736,
-0.015700636,
0.035910312,
0.0021330186,
0.022302194,
-0.0027101487,
-0.0060109273,
-0.0230717,
-0.027027234,
-0.0020604555,
-0.00025228344,
-0.010415341,
-0.007006561,
-0.0041782865,
-0.01837366,
-0.008275572,
-0.018751662,
0.0016875147,
0.01035459,
-0.006196554,
0.005551923,
0.010077838,
0.031239271,
-0.01494463,
-0.017739154,
-0.021465186,
0.004279537,
-0.012926362,
0.0013989497,
0.030402264,
-0.016186642,
0.03329129,
-0.039150342,
-0.009774085,
-0.00036808915,
0.0091058295,
0.007573566,
-0.029943261,
-0.025596222,
-0.015808638,
0.0003818002,
0.016753646,
-0.013081614,
-0.012008354,
-0.0088493265,
-0.016686145,
-0.010752844,
0.00230177,
-0.010422091,
-0.013385367,
-0.00014618096,
-0.023746707,
0.022410195,
0.024637714,
0.017442152,
0.014310124,
0.0102668395,
0.0345063,
-0.024448713,
0.03323729,
-0.015336134,
0.018022656,
-0.0026274603,
-0.04131036,
0.0077490676,
0.018846164,
-0.010469341,
0.019386169,
0.015552135,
-0.026122727,
0.009382581,
-0.00807307,
0.032238282,
-0.032346282,
-0.0057746754,
-0.025096718,
-0.024340712,
0.020493178,
0.011994855,
-0.0032096528,
-0.0066454327,
-0.010590842,
0.003553906,
-0.00027696334,
-0.007128062,
-0.007809818,
-0.007620816,
-0.027027234,
0.016726645,
-0.025231719,
0.009861836,
0.0073103136,
-0.0059400517,
0.050922442,
-0.016227141,
0.009936087,
-0.0032113404,
-0.019251168,
0.00045605085,
0.018144159,
0.011718102,
-0.000351214,
-0.009956337,
0.01614614,
-0.002173519,
-0.009483833,
0.025866225,
0.013473117,
0.009882086,
-0.0019372669,
-0.010806844,
0.009821336,
-0.0020874557,
-0.015120132,
0.031617276,
-0.0014529502,
-0.008640075,
0.034263298,
-0.012460608,
0.0052582957,
-0.008410573,
-0.008417323,
0.012291857,
-0.004971418,
0.004812792,
0.0011356974,
0.044253387,
0.04241737,
0.008930327,
-0.012109606,
0.0007036936,
-0.019642672,
-0.009591834,
0.009821336,
0.011353599,
0.007992069,
-0.013959122,
-0.005619424,
-0.02983526,
0.0033682792,
0.014472126,
-0.04228237,
0.012433608,
0.00691206,
0.011049846,
0.0055620484,
0.01941317,
0.022045692,
0.0062876795,
-0.008484824,
0.02544772,
0.028971251,
-0.008592824,
-0.0010563842,
-0.027337737,
-0.02419221,
0.0026696483,
-0.0032113404,
-0.0051266695,
0.007951569,
-0.0009677897,
-0.0228692,
-0.015282133,
-0.039636344,
-0.0026645856,
-0.016281141,
0.002127956,
-0.013270616,
0.008646825,
0.009416332,
-0.028485248,
-0.005055794,
0.016294641,
0.009578333,
-0.008896577,
0.009612083,
-0.0009551333,
-0.02181619,
0.009031579,
-0.005150295,
0.0040804106,
-0.009780835,
-0.011083596,
-0.0038475334,
0.022018692,
-0.0035977813,
0.01827916,
0.022059191,
-0.006561057,
-0.029619258,
-0.025623223,
-0.030699268,
0.008302572,
0.03933934,
-0.0006269117,
0.019804671,
-0.0017853905,
0.008363322,
-0.01260236,
-0.018576162,
0.0077490676,
-0.03207628,
-0.0114548495,
-0.009288081,
-0.0020368302,
-0.01613264,
0.030699268,
0.01966967,
-0.013527118,
-0.0074318144,
0.002333833,
-0.0072090626,
0.023436204,
0.01723965,
0.021100683,
0.03793533,
0.013331366,
0.010415341,
0.020331176,
0.024732215,
-0.017023647,
-0.00260046,
-0.01714515,
0.013095114,
-0.009861836,
-0.006203304,
0.007006561,
-0.021208685,
0.007863819,
0.035937313,
0.011603351,
0.026487231,
0.004593415,
0.010739343,
0.00801232,
-0.024961717,
0.0035235307,
-0.02652773,
0.0097268345,
-0.004485414,
-0.020844182,
-0.008329572,
0.022032192,
-0.015538635,
-0.014107623,
-0.006662308,
0.0045630396,
0.007141562,
0.0008112727,
-0.008937078,
0.0070335614,
0.0054574227,
-0.009956337,
-0.017185649,
-0.017955156,
-0.015255133,
-0.013236865,
-0.010131838,
0.0013289178,
0.012089355,
-0.025056219,
-0.0083970735,
0.016686145,
-0.015741138,
-0.0460084,
0.000368511,
0.017995657,
0.041148357,
0.02184319,
0.0027590864,
0.005082794,
0.033993296,
0.0032906537,
-0.025096718,
-0.0021853314,
-0.014553127,
0.004860042,
-0.0069660605,
0.0042120367,
-0.0079448195,
-0.00047545726,
-0.0028502124,
0.008154071,
-0.019804671,
-0.001408231,
0.0003174637,
-0.01961567,
0.0027573989,
0.027135236,
0.013419117,
0.0014715128,
-0.00797857,
-0.025015717,
-0.028917251,
-0.0022106443,
-0.020088175,
-0.016510643,
-0.009956337,
0.020439178,
0.0006901935,
0.0010437279,
-0.003921784,
0.021519188,
-0.018265659,
0.015795138,
0.012804861,
-0.0087075755,
0.019885672,
0.008167571,
0.0092745805,
0.006567807,
-0.0027354613,
0.009085579,
-0.008862827,
0.027918244,
-0.00027337737,
-0.0345333,
0.0039319093,
0.026973234,
-0.01729365,
-0.0343173,
-0.0022275194,
-0.010611093,
0.02650073,
-0.004009535,
-0.02978126,
-0.0117383525,
0.0077693174,
-0.016362142,
0.006540807,
-0.0030999645,
-0.021411186,
-0.013986122,
0.014391125,
-0.01954817,
0.0020250175,
0.020047674,
-0.042849373,
-0.00076908484,
0.008511824,
0.0147691285,
-0.00049908244,
-0.029619258,
-0.00024764278,
-0.009456832,
-0.02173519,
-0.025731225,
-0.04139136,
0.013142364,
-0.031806275,
0.01606514,
0.0065036817,
0.03774633,
0.009416332,
0.021154685,
0.022680197,
0.0115021,
0.00019954861,
0.00037441732,
0.033021286,
-0.021721689,
0.02997026,
-0.017604154,
-0.015106631,
0.029187255,
-0.013257115,
0.011002596,
0.007850318,
-0.01036134,
-0.01269686,
0.029349254,
-0.033048287,
-0.031590275,
0.044307385,
-0.0130681135,
0.001436075,
-0.03361529,
-0.014904129,
0.036450315,
0.002082393,
0.006456431,
-0.00055772363,
0.022099692,
-0.0104355905,
0.0011086971,
-0.020898182,
0.0032214655,
-0.0046879156,
0.0022764574,
0.014391125,
-0.0074183145,
-0.011414349,
-0.0028620248,
0.020560678,
0.0021785814,
0.009922586,
0.0048195417,
0.03221128,
-0.014377625,
0.003780033,
-0.029106254,
-0.024583714,
-0.02187019,
-0.022599196,
-0.0073373136,
-0.021019682,
-0.009409582,
0.011751852,
-0.027351238,
0.02986226,
-0.016794147,
-0.015781637,
0.025933726,
-0.009693084,
0.039555345,
-0.021276185,
0.0032248406,
0.018076656,
-0.003928534,
-0.014971631,
-0.01721265,
-0.0028805875,
-0.0054844227,
0.029160254,
0.022059191,
-0.0017102961,
-0.015835637,
0.009618834,
0.04023035,
-0.029349254,
-0.032508284,
0.02417871,
0.012042105,
-0.005541798,
-0.021235684,
-0.015903138,
-0.014215624,
0.01259561,
0.00020672055,
0.0051064193,
0.0006484275,
-0.009740335,
-0.012960113,
0.02185669,
-0.015093131,
0.039582346,
0.013587868,
0.007965069,
-0.018441161,
-0.0013238552,
-0.0030780267,
0.0055316733,
-0.00095682085,
0.014040122,
-0.005406797,
-0.00065813074,
0.012298607,
-0.015903138,
0.006979561,
0.0028468373,
0.0073035634,
0.042363368,
0.0035235307,
-0.012136606,
0.016119141,
0.0004182927,
0.01956167,
-0.016537644,
-0.0015938577,
-0.015106631,
-0.01956167,
-0.018495161,
0.024408212,
0.00011348536,
0.0029464005,
0.014175124,
-0.023517204,
-0.004016285,
-0.034965303,
-0.0026578356,
0.0042052865,
-0.042039365,
-0.0044989143,
0.0035741562,
0.021181684,
-0.0017921405,
-0.00923408,
-0.0037496577,
0.004961293,
0.017604154,
0.007128062,
0.011380599,
0.03226528,
0.013736369,
-0.029349254,
-0.008410573,
-0.0025667099,
-0.008484824,
0.008464574,
-0.031698275,
-0.0343983,
0.012136606,
0.0054337974,
0.019845173,
-0.0025143968,
-0.012231106,
0.008221571,
0.024543213,
0.013088364,
0.012008354,
-0.016456643,
0.00632143,
-0.00807982,
-0.013074864,
0.025488222,
-0.015687136,
-0.010658342,
-0.008977578,
0.0022865825,
0.013540618,
-0.045522396,
0.012467358,
-0.01837366,
0.0032737786,
0.00096863345,
-0.0000117664595,
-0.009396082,
-0.0015887951,
-0.040500354,
0.014647627,
-0.006766934,
-0.00807307,
-0.021073684,
0.01266986,
0.009409582,
0.009713335,
-0.019359168,
-0.0136081185,
0.01032759,
-0.035343308,
-0.037314326,
0.01721265,
-0.007735567,
0.028134245,
0.016510643,
-0.010840595,
-0.015511635,
-0.017874155,
-0.03577531,
-0.004954543,
0.008984328,
0.01714515,
0.012494358,
0.014067123,
-0.004745291,
-0.0092745805,
-0.013432617,
0.026203727,
0.005403422,
-0.015066131,
0.0085388245,
-0.009693084,
0.014107623,
-0.0039319093,
-0.009355581,
-0.013155865,
0.041688364,
0.0049849185,
-0.0054540476,
0.012170356,
-0.015471134,
0.010077838,
-0.020209676,
0.012129855,
0.0032383406,
0.032238282,
0.020871181,
-0.054675475,
0.008599575,
0.018832663,
0.0013508555,
-0.009038328,
0.00064716185,
-0.007809818,
-0.0053865467,
0.008390323,
-0.026365729,
-0.019197168,
0.013034363,
0.0037597828,
0.040500354,
0.026878733,
0.021762189,
-0.0029531508,
0.029592257,
0.0018697663,
-0.015754636,
-0.003564031,
-0.009915836,
-0.013945621,
0.009315081,
-0.004330163,
0.007040311,
0.014553127,
0.013506868,
-0.037530325,
-0.0046406654,
0.011954354,
0.01269011,
-0.0028113995,
0.025434222,
0.011090347,
-0.014580127,
0.015160632,
0.011589851,
-0.016240641,
-0.02872825,
-0.0062674293,
0.00629443,
-0.021168184,
-0.020034174,
-0.0018680787,
-0.0047520413,
0.012001605,
-0.011279348,
-0.014742129,
-0.0050794194,
-0.0040770355,
0.17344952,
-0.014850129,
-0.009659334,
-0.00916658,
-0.00046786346,
-0.005268421,
0.007607316,
0.007958319,
-0.00019079463,
-0.009861836,
0.0045630396,
0.0073103136,
0.003658532,
-0.00032210437,
0.02538022,
-0.023854708,
-0.011731602,
-0.004505664,
-0.0006003333,
-0.024745716,
0.00691206,
-0.016780647,
0.029025253,
-0.00043369128,
0.031428274,
0.012028605,
-0.026703233,
0.018549161,
0.033777293,
0.017442152,
-0.023719706,
0.028917251,
0.008464574,
0.006233679,
0.0061256783,
-0.0039656595,
-0.013250365,
0.0033142788,
-0.0013348241,
-0.0012445421,
0.014175124,
-0.0045427894,
0.012352607,
0.0047756666,
-0.00807982,
0.033831295,
0.003229903,
-0.01836016,
-0.0051199193,
-0.0028991501,
-0.04959943,
0.0028839626,
0.0113130985,
0.023193201,
0.0050017936,
0.0028248995,
0.00803257,
0.014323625,
0.0003950894,
0.036882322,
-0.01725315,
0.022653198,
-0.035019305,
0.030402264,
-0.0069593107,
0.012285107,
0.004600165,
-0.0070740613,
0.022491196,
-0.014688128,
0.009787586,
-0.0016748583,
-0.012264857,
0.009774085,
0.0078300685,
-0.015619636,
0.0343443,
-0.0015626386,
0.0007990382,
0.024570214,
0.023679206,
0.018846164,
-0.011333348,
-0.004910668,
-0.017874155,
-0.046305403,
0.017982157,
0.005059169,
-0.03105027,
-0.0107190935,
0.0230582,
-0.016402643,
-0.012190606,
-0.01941317,
0.01829266,
-0.023085201,
0.011630351,
0.012217606,
-0.0013272302,
-0.00013468477,
-0.023719706,
0.058428507,
0.016605144,
0.008613075,
-0.012555109,
0.0066960584,
0.010820344,
0.015187632,
-0.013351616,
0.0052717957,
-0.006567807,
-0.01034109,
0.0028012744,
0.00009782312,
-0.013972621,
0.023854708,
-0.0063821804,
-0.02417871,
0.035397306,
-0.023881707,
0.005865801,
-0.02178919,
-0.014053622,
0.04109436,
-0.010550342,
-0.0069998107,
-0.0071483124,
0.023854708,
-0.0066285576,
-0.037260324,
0.011691102,
-0.024570214,
0.0023962709,
0.016888646,
0.012494358,
-0.0030223387,
0.022477696,
0.00920033,
-0.00917333,
0.021627188,
-0.0025160844,
-0.02168119,
0.026001226,
0.00092307053,
0.015633136,
-0.007249563,
0.002694961,
0.014863629,
-0.0077760676,
-0.02875525,
-0.008484824,
-0.02872825,
0.019953173,
-0.0053055463,
0.016821146,
-0.026662732,
-0.009551333,
-0.034992304,
0.008619825,
-0.011319849,
-0.010982346,
0.013203115,
-0.0063923057,
-0.031536274,
-0.008464574,
-0.010017087,
-0.16966948,
0.005666674,
0.020263676,
-0.026541231,
0.014607127,
0.024219211,
-0.008464574,
-0.01382412,
-0.002777649,
0.008667075,
0.05626849,
0.008464574,
-0.041688364,
-0.017428651,
0.012744111,
-0.010381591,
0.0001359504,
0.025852725,
0.011063347,
0.016780647,
0.02883625,
-0.028971251,
0.030078262,
-0.00079481944,
0.012939863,
0.017874155,
-0.0005235514,
-0.021181684,
0.0039622844,
-0.038097333,
-0.020911682,
0.007823318,
0.012919612,
0.00028392434,
0.03107727,
0.0029177128,
0.0014217311,
-0.012028605,
-0.007701817,
0.02181619,
0.016996648,
0.02181619,
0.006547557,
-0.007472315,
-0.013311116,
0.030942269,
-0.0085388245,
-0.0063518053,
0.022666696,
-0.018198159,
0.027283737,
-0.021316685,
-0.003925159,
0.021154685,
0.015538635,
0.015835637,
0.01380387,
0.011751852,
0.017374652,
-0.0022190819,
0.0055451733,
-0.012224357,
0.022585696,
-0.0005556142,
-0.00045773835,
-0.023247203,
-0.0012993863,
0.010928345,
-0.033561293,
-0.0079448195,
-0.022167193,
-0.009517583,
0.019278167,
-0.037503324,
0.020844182,
0.0025093344,
-0.021141184,
0.024732215,
-0.0061324285,
0.027094735,
-0.024097709,
0.0024080835,
-0.044361386,
-0.021694688,
-0.012771111,
-0.0005201764,
0.024570214,
0.03102327,
0.0060176775,
-0.0027978993,
-0.0008121164,
-0.024219211,
-0.0087075755,
-0.0053831716,
0.027054235,
0.010752844,
-0.006682558,
0.008552324,
0.000116965864,
0.0102668395,
0.044496387,
-0.017482651,
-0.031131271,
0.00402641,
0.03202228,
-0.0028080244,
-0.022140192,
0.027283737,
0.031239271,
-0.004475289,
-0.006436181,
0.0020553928,
-0.009693084,
0.020020675,
-0.0036079064,
0.04171536,
0.0024907717,
-0.008289072,
0.026649231,
-0.0044044135,
0.055566482,
0.0038070332,
0.0041884114,
0.01961567,
-0.01961567,
-0.02411121,
-0.13899721,
-0.034614302,
0.014080622,
0.026919235,
-0.018252159,
0.011711352,
-0.010536842,
0.022140192,
-0.032103278,
0.037260324,
-0.043038376,
-0.014458626,
0.014863629,
-0.017644653,
0.0028316497,
-0.015619636,
0.016227141,
0.004731791,
-0.027067736,
0.02407071,
-0.012177106,
-0.008221571,
-0.008876327,
0.0012656361,
-0.013155865,
0.0127576105,
-0.030726267,
0.010165588,
0.0027320862,
0.01382412,
0.012966863,
-0.012352607,
0.040932357,
0.0004429726,
-0.024367712,
-0.012831862,
0.006621808,
-0.02883625,
0.036504317,
-0.007229313,
-0.0026932734,
0.0046305405,
0.036126316,
0.011333348,
-0.00919358,
0.000015807267,
-0.032238282,
-0.0072090626,
0.008086571,
-0.03191428,
-0.025771724,
-0.037503324,
-0.0060615526,
-0.021438187,
0.029511256,
-0.0009239143,
0.0114278495,
0.018765163,
-0.011144347,
-0.0075195655,
0.0010892907,
-0.005855676,
-0.0017162025,
-0.0038711587,
0.0229772,
-0.0007420846,
-0.04382138,
-0.051921453,
0.02643323,
-0.024772715,
0.014242624,
0.012750861,
-0.015727637,
-0.004482039,
-0.02651423,
0.0017432027,
0.008559074,
-0.0074520647,
0.0055856737,
-0.014715128,
-0.021370687,
-0.015822137,
0.013945621,
-0.012980363,
0.014391125,
0.01491763,
0.02070918,
-0.015849138,
0.01740165,
-0.035154305,
-0.0022494572,
0.023098702,
0.005639674,
-0.01602464,
-0.0075330655,
-0.008181071,
0.012521359,
0.006429431,
0.033021286,
0.012190606,
-0.01953467,
-0.03566731,
-0.0461164,
0.01952117,
-0.010631342,
0.007587066,
0.023179702,
-0.02883625,
-0.0077895676,
-0.0075533157,
0.0014909193,
0.0033868419,
-0.012744111,
-0.010449091,
0.00084333547,
-0.010239839,
-0.020128675,
-0.012069105,
0.03213028,
-0.017752655,
0.006574557,
0.0021954565,
-0.007202313,
0.0012529796,
0.010712343,
0.0014900755,
-0.02864725,
-0.012541609,
-0.011967855,
0.011542601,
0.009747085,
-0.01956167,
0.0033885294,
-0.045414396,
0.011927354,
-0.0067061833,
-0.005960302,
-0.03361529,
0.01595714,
0.026595231,
0.025434222,
0.040851355,
-0.027229737,
-0.028269246,
0.019899173,
0.00045816024,
-0.013155865,
-0.0023658955,
-0.017590653,
0.000803257,
-0.0050051687,
-0.008660326,
0.017779654,
0.015133631,
0.0020975808,
-0.032454282,
-0.015241632,
-0.006675808,
-0.0019372669,
0.002868775,
-0.02512372,
-0.004232287,
0.014310124,
0.011070096,
0.0028282746,
0.010698843,
0.025420722,
-0.00024300211,
-0.03931234,
0.005150295,
0.019750671,
-0.009261081,
-0.027837243,
-0.018036157,
0.021721689,
0.0040669106,
-0.006895185,
-0.014391125,
-0.008167571,
-0.009774085,
-0.020277176,
0.03191428,
0.015579135,
0.0061729285,
-0.016956147,
0.0228692,
0.032643285,
0.014364125,
0.00039825347,
0.033048287,
-0.014026622,
-0.009490582,
0.0043031625,
0.0015449197,
0.005494548,
0.01728015,
0.007020061,
0.020169176,
-0.029673258,
-0.0018410785,
-0.011994855,
0.015700636,
-0.01494463,
0.011124097,
0.028809251,
-0.020911682,
0.000029927018,
0.008822327,
-0.040608354,
-0.035262305,
-0.017901156,
-0.015282133,
0.003400342,
0.009247581,
0.0074858153,
0.0028248995,
-0.02625773,
0.035937313,
-0.00173139,
-0.015511635,
0.0035809062,
0.0007416627,
0.017320652,
-0.007458815,
-0.000070664675,
0.0010217901,
0.01144135,
0.0014521064,
0.04506339,
-0.007654567,
0.022639697,
-0.011859853,
0.022626197,
0.012966863,
-0.023368703,
-0.012784611,
-0.0007382877,
-0.037152324,
-0.01030059,
0.024367712,
-0.012129855,
0.0924488,
-0.009551333,
-0.025501722,
-0.009396082,
-0.021586688,
0.02864725,
-0.0102668395,
0.027189236,
-0.032994285,
-0.029079253,
0.027256737,
-0.014620627,
0.046521403,
-0.031509273,
-0.010644843,
0.008775076,
-0.0070605613,
-0.00051764515,
0.01840066,
0.0037530325,
0.037503324,
0.0026662732,
0.01268336,
0.016699646,
-0.031563275,
-0.0032889661,
0.0076275663,
-0.009814586,
0.0008543043,
-0.019723672,
0.00056911435,
-0.0114548495,
-0.03912334,
0.014499126,
-0.012001605,
0.011832853,
-0.012345857,
-0.028350247,
-0.0027860866,
0.02431371,
0.0048026666,
-0.0091058295,
-0.0056599244,
-0.0142021235,
0.002190394,
-0.027337737,
-0.0027287113,
-0.009396082,
-0.027486239
] |
Genetic mutations in TAR DNA-binding protein 43 (TARDBP, also known as TDP-43) cause amyotrophic lateral sclerosis (ALS), and an increase in the presence of TDP-43 (encoded by TARDBP) in the cytoplasm is a prominent histopathological feature of degenerating neurons in various neurodegenerative diseases. However, the molecular mechanisms by which TDP-43 contributes to ALS pathophysiology remain elusive. Here we have found that TDP-43 accumulates in the mitochondria of neurons in subjects with ALS or frontotemporal dementia (FTD). Disease-associated | [
-0.025672028,
-0.0046377587,
0.018251615,
-0.047594793,
-0.013786348,
0.033066403,
-0.013135434,
0.017092988,
-0.018629143,
0.00055734464,
-0.0016573884,
0.0201653,
0.009399191,
0.012907614,
-0.0009999658,
-0.020113226,
0.023042338,
0.00812991,
0.009366645,
0.017262226,
-0.011618805,
0.011892189,
-0.002616672,
-0.009789739,
0.021831637,
0.005220326,
0.0054741823,
-0.021454109,
-0.012595176,
0.0121981185,
0.019449295,
-0.0023937344,
-0.005575074,
-0.019618532,
0.021584291,
-0.007986709,
0.015973417,
0.00042431423,
0.012699322,
-0.017652774,
0.00065091345,
0.0107465815,
-0.0059981677,
-0.009835303,
-0.014385188,
0.0019804041,
-0.009861339,
-0.023862489,
-0.0108051635,
0.011215239,
0.013024779,
0.008383766,
-0.022534624,
-0.02482584,
-0.00023005724,
-0.0065937536,
-0.0008075395,
0.025034131,
0.007537578,
-0.016845642,
0.0121981185,
-0.008377257,
-0.00458894,
-0.001038207,
-0.0058126575,
-0.0032448038,
0.006886665,
0.005324472,
0.009887376,
0.016376983,
0.014202932,
0.020412646,
0.010525271,
-0.0080518,
0.030332567,
-0.018694235,
-0.017835028,
0.0042472105,
-0.030671043,
0.032623783,
0.019280057,
-0.011098075,
0.021701455,
-0.006024204,
0.011501641,
-0.004533612,
-0.01165786,
0.0052007986,
-0.016376983,
0.0012733495,
0.015387595,
0.0036386063,
0.0079801995,
0.0161036,
-0.017106006,
-0.004406684,
0.002248906,
0.023563068,
-0.024969041,
-0.023263648,
-0.015895307,
0.0010748209,
-0.02046472,
-0.008917514,
-0.01963155,
-0.0023465431,
0.013591073,
-0.0016272836,
0.011312876,
-0.023302702,
-0.0077523794,
0.024226999,
0.016129635,
-0.033795428,
0.010583853,
-0.009985013,
0.030150313,
0.01564796,
-0.009145334,
0.0027273274,
0.04251767,
0.024812821,
0.012875069,
-0.0075440872,
-0.00865064,
-0.011963789,
-0.03181665,
-0.0022440243,
0.013669183,
0.0016199609,
0.0033245406,
0.023966635,
-0.008559512,
-0.0006167405,
-0.027312329,
-0.0043383385,
-0.025541846,
-0.034915,
-0.023406848,
-0.041476205,
-0.010141232,
0.031894762,
-0.032545675,
-0.0051877806,
-0.009184389,
0.041241877,
-0.0032838585,
0.028015316,
0.00872875,
0.0074724867,
0.0024441802,
0.009763702,
-0.00016181302,
-0.023354776,
-0.003332677,
0.0066295536,
-0.011280331,
0.020178318,
-0.027364403,
-0.028041353,
-0.0070233564,
0.010551307,
-0.014033695,
0.011716442,
0.025606936,
0.031946834,
-0.015205339,
-0.015257412,
0.009971995,
-0.010648944,
-0.00835122,
0.029082814,
-0.020712066,
0.016494147,
-0.009985013,
-0.0062032053,
-0.0032659583,
-0.0020487502,
-0.042101085,
-0.00729674,
0.0019625041,
0.00002076058,
0.02580221,
0.0021073325,
-0.014827809,
-0.0151272295,
0.02046472,
-0.014775736,
-0.0072641945,
-0.025906356,
-0.00107238,
-0.0006789841,
0.0010764481,
-0.03530555,
-0.63320863,
-0.02293819,
0.005135707,
-0.0056076194,
-0.0015890425,
0.014189914,
0.0043904115,
0.009809266,
-0.026388032,
0.01819954,
0.0029990838,
0.023901543,
0.025138278,
-0.014905918,
-0.026973855,
-0.02136298,
-0.004497812,
-0.0035702605,
0.0072186305,
0.0136822015,
-0.021857675,
0.01451537,
0.0043513565,
0.0018502215,
0.007778416,
0.021636363,
-0.011573242,
-0.008325184,
-0.014853845,
0.03853408,
-0.014736681,
0.0151402475,
0.017314298,
-0.010525271,
0.045928456,
0.0077979434,
-0.0018746308,
0.027780987,
0.011423532,
0.026687453,
0.00038770033,
0.006030713,
0.0011203848,
-0.0076026693,
-0.025541846,
0.027676841,
-0.010290942,
0.008090855,
-0.020360574,
-0.019826824,
0.0062845694,
0.0011211984,
-0.026114648,
-0.014736681,
0.012315283,
0.003619079,
0.008338202,
-0.033482987,
0.029551473,
-0.0046279947,
0.010343015,
0.011755497,
-0.0018274395,
-0.010141232,
-0.008494421,
-0.022482552,
-0.016155673,
0.0005915176,
-0.001933213,
-0.015778143,
0.016051527,
0.011098075,
0.005581583,
0.0021821875,
0.017952194,
0.02197484,
0.00043814615,
0.019774752,
0.0016525065,
-0.0012538221,
-0.011592769,
0.013174489,
-0.013395799,
-0.015856253,
0.026947819,
0.01640302,
-0.011202221,
0.041033585,
-0.01459348,
0.011827098,
0.014020677,
-0.009464282,
-0.00887846,
-0.03251964,
-0.022912154,
0.0040584453,
-0.0039380267,
-0.012764413,
0.009893885,
0.006815064,
-0.0041365554,
-0.007088448,
0.021649383,
0.0021952058,
0.03738847,
-0.0070103384,
-0.024057763,
0.014424243,
0.032832075,
0.0055425283,
0.0042016464,
-0.019371185,
0.0071795755,
-0.01752259,
-0.015075156,
-0.019501368,
0.012009353,
0.010655453,
0.006522153,
-0.026348978,
0.0010447161,
0.003166694,
0.01421595,
0.0028607647,
0.0003364409,
0.0148929,
0.020126244,
0.0027598732,
-0.011182694,
-0.008181983,
-0.0122111365,
-0.009770211,
0.013174489,
-0.020790176,
0.011677388,
-0.0075310688,
0.0056011104,
0.0031634395,
-0.0039510448,
-0.031712506,
-0.018082377,
-0.015908325,
-0.002501135,
0.020035116,
-0.02181862,
-0.0060437317,
-0.011456077,
-0.004159337,
-0.0036841703,
0.016311891,
0.011924735,
0.01053178,
0.0015231376,
0.030358605,
0.021389017,
-0.015973417,
-0.02128487,
-0.01911082,
0.0071275025,
-0.026010502,
-0.008188492,
-0.0028640192,
-0.011124112,
0.0037102068,
-0.0014181777,
-0.034420304,
0.0070298654,
0.026518214,
-0.009620501,
-0.008624604,
0.0019478586,
-0.018459907,
-0.0009511473,
-0.00041699145,
-0.009653047,
0.020673012,
0.02112865,
0.0049176514,
0.007843507,
-0.010160759,
-0.0036906793,
0.0048102504,
0.012634231,
-0.00047353955,
0.044730775,
0.004377393,
0.026166722,
-0.00035698537,
0.008416311,
0.0136952195,
-0.027312329,
0.046761625,
0.014684608,
0.0021594055,
-0.0038110984,
0.008657149,
0.017952194,
0.008168964,
0.0028981923,
-0.0030479024,
0.0050510885,
-0.030072203,
0.02482584,
-0.00887195,
0.004601958,
-0.038195603,
-0.0057736025,
-0.04514736,
0.009125807,
-0.0078695435,
-0.0066002626,
0.0046800678,
0.0067955367,
0.005243108,
-0.0076482333,
0.030827262,
0.018590089,
-0.010323488,
-0.0043057925,
-0.013252598,
-0.0034498414,
0.024943005,
-0.0020210864,
-0.013539,
0.027390439,
0.0023839707,
0.011748988,
0.03405579,
0.009490319,
-0.011000438,
0.011443059,
0.009229953,
0.0069322283,
0.028353792,
0.004601958,
0.0035702605,
-0.0093601355,
0.012133027,
0.05618685,
-0.009086752,
-0.018629143,
0.0026475906,
0.0042699925,
0.00038953102,
0.0019478586,
0.012015862,
0.024396237,
0.023510994,
0.0016826113,
0.016311891,
-0.019696642,
-0.0046149767,
0.001703766,
0.00003485947,
-0.016533202,
-0.016129635,
0.011527678,
0.026713489,
0.03205098,
0.03405579,
0.037518654,
-0.012959687,
0.005470928,
-0.011944262,
0.003446587,
-0.020842249,
-0.0049925065,
-0.0049827425,
0.012334811,
0.003160185,
-0.02414889,
0.0028021825,
0.01008265,
-0.049625643,
0.0078825625,
0.0121590635,
-0.004777705,
0.039367247,
0.021141669,
0.0010072886,
0.013591073,
-0.05431222,
0.034810852,
0.029082814,
-0.015517777,
-0.018772345,
-0.0016541339,
0.0015564968,
0.0018860218,
0.0046670497,
-0.0072772126,
0.017418444,
0.01421595,
0.0284319,
-0.006069768,
-0.0066913906,
0.026440104,
-0.02271688,
0.0108312005,
-0.011371459,
-0.01377333,
0.008787332,
-0.019878898,
-0.0075505963,
0.038117494,
0.0013628501,
-0.018212559,
0.019800788,
-0.004237447,
-0.01670244,
0.013115906,
-0.03853408,
0.006815064,
0.009568428,
-0.007967181,
0.020881305,
0.0040975004,
0.011098075,
0.023602122,
0.025190352,
-0.02355005,
-0.030384641,
0.0013579682,
0.0031878487,
0.016520184,
0.04793327,
-0.026036538,
-0.016038507,
-0.010219341,
0.022170113,
0.021805601,
-0.04808949,
0.03798731,
-0.004348102,
-0.0013742411,
-0.012692813,
0.013929549,
-0.008448857,
0.010818182,
0.038638223,
0.00083886477,
-0.03475878,
0.020412646,
-0.019280057,
-0.01241292,
-0.014944973,
0.0066523356,
0.025151297,
0.020269446,
-0.012458484,
0.00985483,
0.0033522043,
0.0136171095,
-0.01715808,
-0.0042927745,
0.010401597,
-0.004784214,
0.034290124,
-0.0036841703,
-0.007999727,
0.02347194,
0.034185976,
0.0049469424,
0.016376983,
0.012080954,
-0.01150815,
0.020178318,
0.012380375,
0.017483536,
0.0017867575,
0.014228969,
0.012015862,
0.019293075,
-0.008468384,
0.029551473,
0.001408414,
-0.021909747,
-0.008312165,
0.0025320535,
-0.014801772,
0.007615688,
-0.023068374,
0.0020910595,
-0.019957008,
-0.0012391765,
-0.011052511,
0.0041951374,
0.0018274395,
0.006710918,
-0.007153539,
-0.00978323,
0.005783366,
-0.0151011925,
-0.004296029,
-0.0054904553,
-0.01715808,
-0.041267913,
0.0028135735,
-0.000645218,
0.018603107,
0.0019250766,
-0.02910885,
-0.0007204799,
0.031452138,
-0.020282464,
-0.0019804041,
-0.008338202,
-0.011443059,
-0.0013148452,
0.008806859,
0.0016638975,
-0.007042884,
-0.0070689204,
0.015231376,
0.025476754,
-0.026687453,
0.030280495,
0.0015215103,
-0.001615079,
0.0042862655,
0.037909202,
0.036294937,
-0.0010211205,
0.0033945139,
-0.008709222,
-0.02060792,
-0.014281042,
-0.047594793,
-0.018707253,
-0.03603457,
0.0038989717,
0.011111093,
0.012419429,
-0.022430478,
0.014801772,
0.011918225,
0.011833607,
0.009457773,
0.032623783,
0.039237063,
-0.011781534,
0.009952467,
0.0002061565,
0.007615688,
-0.014320096,
-0.021870693,
0.033665244,
0.004920906,
-0.010525271,
-0.0014255005,
0.024487365,
-0.022065967,
-0.014228969,
-0.03241549,
0.00040519363,
0.021415053,
0.016051527,
-0.02662236,
-0.016897714,
0.0011057393,
-0.008195001,
0.0009788112,
0.0047223773,
-0.014333115,
-0.00827962,
0.006040477,
-0.010258396,
-0.0030527841,
0.017861066,
-0.03405579,
-0.021714473,
0.005545783,
0.032311346,
0.0071275025,
-0.02136298,
-0.0010471571,
-0.029551473,
-0.008422821,
-0.018511979,
-0.005516492,
0.0188114,
0.0016215882,
0.025554864,
0.0073813586,
0.02986391,
-0.007680779,
0.0050575975,
0.031191774,
0.019996062,
0.0054025818,
-0.011540696,
0.0122371735,
-0.008142928,
0.016494147,
0.014788754,
-0.0079346355,
0.018381797,
-0.035982497,
0.007628706,
0.009470791,
-0.0076482333,
-0.026466142,
0.0150100645,
-0.047360465,
-0.033899575,
0.0019218221,
-0.014879882,
0.013877476,
-0.052411553,
0.006730445,
0.028223608,
0.0073618316,
0.00325294,
-0.0059916587,
0.018446889,
-0.0004470962,
0.030801225,
0.014528389,
0.005835439,
0.00084700115,
-0.036763594,
0.004077973,
-0.0036386063,
0.022625752,
0.0010731936,
-0.006440789,
0.009991522,
-0.00036796954,
0.0010666845,
0.020842249,
-0.027260257,
-0.0032496855,
-0.03746658,
-0.011879171,
-0.018746309,
-0.046969917,
-0.02082923,
-0.04077322,
0.010622908,
0.018980637,
-0.0023367794,
0.013317689,
0.005539274,
-0.016884696,
0.0228731,
0.00255809,
0.0042634835,
0.0015011692,
0.009809266,
0.024799803,
-0.0072641945,
-0.02046472,
-0.020321518,
0.015192321,
0.011241276,
0.02235237,
0.0074789957,
-0.03587835,
-0.015713051,
0.008865441,
0.0013783093,
-0.018590089,
-0.009535883,
0.021467127,
-0.0051845256,
0.010941856,
0.0021138415,
-0.007452959,
-0.015999453,
-0.009067224,
-0.03611268,
0.01098742,
0.003814353,
-0.015465704,
-0.02361514,
0.0033196588,
0.0107140355,
0.00023188793,
-0.0059460946,
-0.02994202,
-0.0003244397,
-0.010850728,
-0.008930533,
0.014281042,
-0.024018707,
0.036581337,
-0.01399464,
0.014059731,
-0.0076026693,
0.011983317,
0.011404004,
-0.0075180507,
-0.014632535,
0.042751998,
-0.03421201,
0.0066620996,
0.0027598732,
0.012328302,
-0.0029925746,
0.0077393614,
-0.0038761897,
-0.024044745,
-0.026518214,
-0.013324199,
0.034498416,
0.0070103384,
0.007537578,
0.019241001,
-0.021141669,
-0.009073734,
-0.01994399,
-0.025541846,
0.01249103,
-0.048792474,
-0.01964457,
0.000067583125,
0.040877365,
0.011690406,
0.02662236,
-0.0015231376,
-0.0092624985,
0.03166043,
-0.030254459,
0.008168964,
-0.0068280823,
0.003768789,
-0.025437698,
-0.0021528963,
-0.02528148,
-0.023589104,
-0.0027924187,
0.0020926867,
-0.0078695435,
-0.0075115417,
-0.00073227764,
0.020542828,
0.020425664,
-0.018993655,
0.03678963,
-0.015478723,
0.018863473,
0.00744645,
-0.009789739,
0.008533476,
-0.009945958,
0.019449295,
0.009106279,
0.012067935,
-0.029915983,
0.005988404,
-0.022834044,
-0.0046377587,
-0.019227983,
-0.016207745,
-0.010180287,
-0.01767881,
-0.00432532,
0.009913412,
0.022065967,
0.0018843946,
-0.020178318,
-0.0049697245,
0.012998742,
0.007107975,
-0.025984466,
0.026661417,
-0.013324199,
-0.008266601,
-0.00729674,
0.015231376,
0.017053934,
-0.022821026,
-0.022847064,
-0.0108051635,
-0.029811837,
-0.00048330324,
0.010896292,
-0.0108051635,
0.014879882,
0.013968603,
-0.043194618,
-0.012822996,
0.0013156589,
0.016155673,
0.018407833,
0.021922765,
-0.01542665,
0.017444482,
0.03181665,
0.02746855,
0.006762991,
-0.025645992,
0.016715458,
-0.0050217975,
0.005926567,
0.012484521,
-0.028457938,
-0.026427086,
0.022625752,
0.01128684,
-0.01896762,
0.0022342606,
-0.01805634,
-0.016585276,
-0.020868286,
0.011918225,
-0.026635379,
0.011579751,
0.00932759,
-0.029603545,
-0.007622197,
0.0030169839,
0.01437217,
-0.004839542,
0.0107986545,
0.024031725,
0.019175911,
-0.011625315,
-0.04220523,
-0.026283886,
0.0016638975,
-0.015986435,
0.029889947,
0.025932392,
0.009646538,
-0.00097148836,
0.0061511323,
0.0014230596,
-0.01993097,
-0.014541407,
-0.043871567,
-0.019917952,
0.0008478148,
-0.019657588,
-0.010466688,
0.0021382507,
0.0063529154,
-0.026348978,
0.0011724579,
-0.013499945,
-0.024448311,
-0.036893778,
0.024630565,
-0.0018193031,
-0.016819604,
0.01135844,
-0.0150881745,
-0.020555848,
-0.020751122,
-0.0036841703,
0.0150100645,
-0.026492178,
-0.0053374907,
-0.0006708477,
-0.021011487,
-0.014098786,
-0.017626736,
-0.0150621375,
-0.024630565,
0.02535959,
0.19121234,
-0.024240017,
-0.0030169839,
-0.002110587,
-0.019475332,
0.014554425,
0.015387595,
-0.0026768816,
-0.014489334,
-0.009203916,
0.028327754,
0.008266601,
-0.011332404,
0.0039380267,
0.0050152885,
-0.013760311,
-0.021779565,
-0.0043448475,
-0.016155673,
-0.019019691,
0.012087463,
-0.013760311,
-0.0019088038,
-0.0069647743,
0.038169567,
0.016272837,
-0.024435291,
-0.024161909,
0.0019576224,
0.0011765261,
-0.032832075,
-0.0047158683,
0.0004946942,
-0.022821026,
0.0041333004,
-0.005210562,
-0.021245817,
-0.021857675,
-0.012731868,
-0.0042407014,
0.0031634395,
0.015439668,
-0.020191336,
-0.013018269,
-0.0021349962,
0.006086041,
0.00216266,
-0.006007931,
-0.014710644,
0.005936331,
-0.034107868,
-0.014788754,
0.010661962,
0.006776009,
0.01180757,
-0.011338913,
0.014997046,
0.024435291,
-0.004608467,
0.044626627,
0.013851439,
0.0054676733,
-0.041502245,
0.031243848,
-0.01948835,
0.024500383,
-0.008435839,
0.017366372,
0.03918499,
-0.02090734,
0.006463571,
-0.026218794,
-0.009080243,
0.00034498415,
-0.007257685,
-0.013233071,
0.061342087,
0.007140521,
0.027260257,
0.031634394,
0.010811673,
0.011534187,
-0.014046713,
0.0068085548,
-0.019917952,
-0.048870582,
0.0079281265,
-0.015023083,
-0.005867985,
-0.01993097,
0.007036375,
-0.0136822015,
0.009581447,
0.0013319317,
0.015530796,
0.008663658,
-0.009093261,
-0.022508588,
0.004846051,
-0.02910885,
-0.02806739,
0.07160048,
-0.012048408,
-0.002151269,
-0.023966635,
0.013356744,
0.004354611,
-0.002764755,
0.016988842,
-0.012295756,
0.00812991,
-0.032103054,
-0.0039542993,
-0.004123537,
0.01226321,
0.022808008,
0.015830215,
-0.008318674,
0.030983482,
-0.013864457,
0.010486216,
-0.034107868,
0.00032789767,
0.010434143,
0.0053505087,
0.0029356198,
-0.018290669,
-0.014957991,
-0.011338913,
-0.04236145,
-0.0030706844,
0.0079736905,
-0.016455093,
0.00842933,
-0.019996062,
-0.0067695,
-0.00033176245,
-0.008494421,
-0.024318127,
0.046110712,
-0.018538015,
-0.014424243,
0.0073162676,
-0.00059965404,
-0.017808992,
-0.009926431,
0.0042537195,
0.007954163,
-0.002065023,
-0.0063398974,
-0.02970769,
-0.014528389,
0.00056466745,
-0.0022358878,
0.0022749426,
-0.006281315,
-0.015634941,
-0.029681655,
-0.02655727,
0.012269719,
-0.023524012,
0.020594902,
0.014241987,
-0.012041899,
0.009041188,
0.0026020266,
-0.16236386,
0.021480145,
-0.0049078874,
-0.020113226,
0.015478723,
0.011781534,
0.023146484,
-0.0042537195,
-0.016650368,
0.006053495,
0.02181862,
0.02174051,
-0.02994202,
-0.018902527,
-0.0068280823,
-0.007251176,
0.0040161363,
0.03678963,
0.0051715076,
-0.008845914,
-0.0038468987,
-0.031738542,
0.036581337,
-0.0107465815,
-0.014255005,
0.034133904,
0.009366645,
-0.0026182996,
0.008715731,
-0.008494421,
-0.014228969,
-0.02219615,
0.043819495,
-0.0042992835,
0.03166043,
0.008982606,
-0.0055034733,
-0.029759765,
-0.009679084,
0.007003829,
-0.0019364676,
0.035071217,
0.020868286,
-0.0011089938,
-0.01904573,
0.028900558,
0.0017232934,
-0.020946397,
0.0135650365,
-0.008865441,
0.014059731,
-0.0024100072,
0.018030303,
0.034342196,
0.024096817,
-0.00993294,
0.0037655344,
0.012386884,
-0.009568428,
-0.023901543,
-0.025450718,
0.0030950936,
0.033665244,
0.006053495,
0.02858812,
-0.03166043,
-0.013356744,
-0.010388579,
-0.029889947,
0.00035718878,
-0.021493163,
0.0077588884,
-0.0025076442,
-0.010225851,
-0.003746007,
0.0055197463,
-0.010024068,
0.025190352,
-0.012621213,
-0.025008095,
-0.015947381,
0.024565475,
-0.033509027,
-0.023888525,
0.0077588884,
-0.0075636148,
-0.0014678099,
0.022404442,
-0.0035377147,
-0.02203993,
-0.008357729,
-0.02383645,
0.02490395,
-0.010264905,
0.0047061043,
0.017808992,
-0.017496554,
0.018694235,
-0.011788043,
-0.0015849744,
0.022899136,
-0.01805634,
-0.019904934,
0.02008719,
0.043767422,
0.017275244,
-0.038403895,
0.009522865,
0.011052511,
-0.022000875,
-0.010258396,
0.0036516245,
0.009867848,
0.016390001,
0.0042634835,
0.012868559,
-0.008162455,
-0.006418007,
0.0019234493,
-0.0053960728,
0.06457061,
0.0069322283,
-0.004462012,
-0.0010194932,
0.0016874932,
-0.024838857,
-0.1137276,
-0.026869709,
-0.0075440872,
0.01188568,
-0.011443059,
0.00013597989,
0.009998031,
0.03504518,
-0.020803194,
0.024461329,
-0.020048136,
-0.018472925,
0.007049393,
-0.006632808,
-0.0034400776,
0.001279045,
0.013213543,
0.012146045,
-0.032884147,
0.044860955,
0.008520457,
0.006336643,
0.016741494,
-0.02632294,
-0.0021577782,
-0.013825403,
-0.039523467,
0.013220052,
0.0032545673,
0.0018062849,
0.012920632,
-0.018524997,
0.028249646,
-0.0010390206,
-0.017795974,
-0.00015103226,
0.001069939,
-0.020295482,
0.040955476,
-0.008793841,
-0.010954874,
0.0034726234,
0.02293819,
0.021349963,
0.016311891,
-0.015752107,
-0.021389017,
0.018147469,
0.026335958,
0.00887195,
0.0028021825,
0.0030885844,
-0.01045367,
-0.013115906,
0.012080954,
0.002955147,
0.0054676733,
0.03236342,
-0.020360574,
-0.012373866,
0.0030446479,
-0.0023986162,
-0.0022131058,
0.014241987,
0.04280407,
-0.03564402,
-0.008025764,
-0.05191686,
0.022547644,
-0.016455093,
0.009874358,
-0.0021024505,
-0.02309441,
-0.020516792,
-0.009158352,
0.032467563,
-0.02331572,
-0.01459348,
0.030124275,
-0.0031650667,
-0.0150881745,
-0.00084130565,
0.022964228,
-0.013044306,
0.028874522,
0.015244394,
0.012126518,
-0.0150881745,
0.013291653,
-0.02798928,
-0.0055653104,
0.04092944,
-0.014320096,
0.0079346355,
-0.024643585,
0.030957446,
-0.009627011,
-0.02112865,
0.020074172,
0.04056493,
-0.025489772,
-0.024318127,
-0.04769894,
0.02339383,
0.0046540312,
0.008416311,
-0.0021903238,
-0.018134449,
0.016936768,
-0.005083634,
-0.0011423532,
0.01632491,
0.0020943142,
-0.006557953,
0.022677826,
-0.013525982,
-0.0019722679,
-0.015218357,
0.029759765,
-0.0035344602,
0.03650323,
0.040044196,
0.0056173834,
-0.010284433,
0.007309758,
0.021519199,
-0.013285144,
-0.021922765,
0.002569481,
0.018017285,
0.002977929,
-0.004266738,
0.0044847936,
-0.043897606,
0.011950771,
-0.021428071,
-0.011169675,
-0.012172082,
0.005994913,
0.00895006,
0.02189673,
0.044210043,
-0.00917788,
-0.031478174,
0.019071765,
-0.0073162676,
-0.013578055,
-0.011410513,
-0.032884147,
-0.0024799802,
0.011124112,
0.00073919364,
0.009060715,
0.009757193,
0.005786621,
-0.024851877,
-0.018707253,
0.013812384,
0.02970769,
-0.0012725359,
-0.0069777924,
-0.007387868,
0.012634231,
0.020204354,
0.00054351275,
0.00865064,
-0.00077540067,
0.008546494,
-0.02699989,
0.014710644,
-0.004071464,
-0.0308533,
-0.0060827862,
0.011228258,
0.029681655,
0.0036158243,
0.00031772713,
0.0019364676,
-0.032311346,
-0.018069359,
-0.01782201,
-0.0032919948,
0.009991522,
0.0028200827,
-0.03272793,
0.0067890277,
0.026739525,
-0.0093015535,
-0.0029616563,
0.021649383,
0.0041495734,
0.0004605213,
-0.0068085548,
0.021454109,
0.008331693,
0.02647916,
0.015634941,
0.015218357,
-0.0046149767,
-0.014281042,
-0.0026882726,
0.008422821,
-0.007153539,
-0.012588667,
-0.011872662,
-0.0177439,
-0.008761295,
0.013083361,
-0.03345695,
-0.035227437,
-0.0043904115,
-0.01685866,
0.033430915,
0.009034679,
-0.018902527,
0.008227547,
-0.015726069,
0.03483689,
0.00413981,
-0.008858932,
-0.008585549,
0.018564053,
0.025776174,
0.010290942,
0.0064342795,
0.024656603,
0.018915545,
0.021245817,
0.03619079,
-0.03225927,
0.01113713,
-0.023380812,
0.008162455,
0.012328302,
-0.029317142,
0.0065188985,
0.002937247,
-0.031894762,
-0.0063106064,
0.024174927,
-0.00033033857,
0.08592058,
0.014137841,
-0.0071209935,
-0.015569851,
-0.011410513,
0.0016679658,
0.01700186,
0.020399628,
0.008025764,
-0.033222623,
0.016689422,
-0.024200963,
0.009282026,
-0.014476316,
-0.02565901,
0.019514386,
0.0041040094,
0.019657588,
0.0094252275,
-0.0013620364,
0.026895745,
0.006378952,
0.0020259682,
0.015621924,
-0.022105021,
0.0045921947,
0.024057763,
0.009132316,
0.008260092,
-0.04647522,
-0.00037671617,
-0.0007623824,
-0.02934318,
-0.0026915271,
0.017066952,
-0.021701455,
-0.021375999,
-0.037336398,
0.006610026,
-0.0033017586,
0.009412209,
0.007921617,
-0.0029811838,
-0.0076872883,
0.012601685,
-0.008162455,
0.0017330571,
-0.02610163,
-0.0033977684
] |
CONTEXT Anxiety about bias, lack of accountability, and poor quality of peer review has led to questions about the imbalance in anonymity between reviewers and authors. OBJECTIVE To evaluate the effect on the quality of peer review of blinding reviewers to the authors' identities and requiring reviewers to sign their reports. DESIGN Randomized controlled trial. SETTING A general medical journal. PARTICIPANTS A total of 420 reviewers from the journal's database. INTERVENTION We modified a paper accepted for publication introducing 8 areas of weakness. Reviewers were randomly allocated to 5 groups. Groups 1 and 2 received manuscripts from which the authors' names and | [
-0.020061614,
-0.0067601847,
0.013580999,
-0.032712962,
0.0060999976,
0.016908882,
-0.009188731,
0.019738257,
-0.02033108,
-0.024170944,
-0.005628435,
0.003964493,
0.003252097,
0.021611035,
-0.021678401,
0.013277852,
0.040069338,
0.013540579,
0.001786885,
0.009323464,
-0.03290159,
0.029910533,
-0.03874896,
0.0039038635,
-0.021058632,
-0.000444195,
0.018175365,
-0.04297955,
0.0028159015,
-0.014753168,
0.0031072597,
-0.012799553,
-0.014645383,
-0.012112419,
-0.0373208,
0.020492757,
-0.0152247315,
-0.012354936,
0.022042178,
0.0040487004,
0.027808713,
0.015669348,
-0.018013686,
-0.008259079,
0.009875866,
-0.015440303,
0.009559245,
-0.017528651,
-0.02012898,
0.04319512,
0.024682926,
-0.010293535,
-0.027283257,
-0.0027552722,
-0.003977966,
-0.019401427,
0.0037219753,
0.005951792,
-0.0064671426,
-0.010731415,
0.0051568723,
-0.004641522,
-0.017326552,
-0.0022904463,
-0.012759133,
-0.024413463,
-0.0029422129,
0.015763659,
0.0049177227,
-0.009175259,
0.045755032,
0.013520369,
0.0041025933,
0.011357919,
0.025208382,
-0.0053454973,
-0.019401427,
-0.019441847,
-0.0065816646,
0.0025969618,
0.0008639698,
0.017784642,
-0.0077336244,
0.014793588,
0.0048671984,
-0.0036512408,
0.023012249,
0.011876637,
-0.013210486,
-0.00018009897,
-0.008292763,
0.023901481,
0.027161999,
0.0033093581,
-0.01601965,
0.02163798,
0.0011039614,
0.033817764,
0.0057362206,
-0.0123482,
0.00543981,
-0.0136146825,
-0.027431462,
-0.018256204,
-0.0152516775,
-0.013008388,
-0.009498616,
-0.015561561,
0.00373208,
0.020694856,
0.001409635,
0.00023999161,
-0.024453882,
-0.012422303,
0.0030062108,
-0.0072216424,
0.0035939796,
0.0028613736,
-0.013446267,
-0.018417882,
0.026730856,
0.0015494195,
0.02813207,
-0.018229257,
0.037132178,
0.0179059,
-0.024467355,
-0.0043720575,
0.004850357,
-0.00748437,
-0.0010180697,
0.03484173,
0.022069123,
0.0078212,
-0.011492651,
-0.0047290977,
-0.012381883,
0.002974212,
-0.015871445,
-0.019509213,
-0.025302695,
0.02281015,
-0.02062749,
-0.0109806685,
-0.012051789,
0.016275642,
0.027081158,
0.023537703,
-0.011283816,
-0.022864044,
-0.018808605,
-0.016962776,
-0.0044966848,
0.0145510705,
0.019940356,
0.011061508,
0.010832463,
0.035192035,
-0.020492757,
-0.0021826606,
-0.0056351717,
0.003398618,
0.015696293,
-0.016262168,
0.025302695,
0.025316168,
-0.012516615,
-0.0025498057,
0.0014231082,
-0.020075088,
-0.011351182,
0.032227926,
-0.033521354,
0.008602647,
-0.0029220032,
0.0007157645,
0.022325115,
0.020479284,
-0.02130115,
0.0009448091,
-0.02515449,
0.00083154987,
0.011351182,
0.036997445,
-0.0008917583,
0.008515071,
0.025397006,
-0.018229257,
0.0009877549,
-0.009114629,
0.0134395305,
0.015871445,
0.0013203749,
-0.015534615,
-0.6454208,
-0.020048141,
0.038021408,
-0.005119821,
0.012354936,
0.002886636,
0.015777133,
0.018390937,
0.013392374,
0.058419853,
-0.00502214,
0.008804745,
0.020762222,
-0.025558686,
-0.028697945,
-0.012435776,
0.02209607,
0.0012269045,
0.056533605,
-0.03368303,
-0.004119435,
0.01979215,
0.017218767,
0.0068241823,
0.014241187,
0.0010803833,
0.026946427,
-0.024885025,
0.0032150454,
0.002287078,
-0.021355044,
0.017097509,
-0.00714754,
0.0023830747,
0.045377783,
-0.014308552,
0.009693977,
0.018795133,
-0.0073631112,
0.028051231,
-0.020452337,
-0.02956023,
0.021233784,
0.011755379,
-0.009815236,
0.01945532,
0.013217222,
0.005904636,
0.012954495,
0.012738924,
-0.023699382,
0.010805517,
-0.026488338,
0.00004089331,
0.0074237403,
-0.0030836817,
0.02100474,
0.002143925,
0.018081052,
0.016383428,
-0.022257749,
0.007154276,
-0.02691948,
-0.042144213,
0.007053227,
0.025046704,
0.0011359603,
0.032766856,
0.006366093,
-0.0047223615,
0.031796783,
0.0075113163,
-0.012186522,
0.010448477,
0.030287784,
-0.0058440063,
0.04095857,
0.0044023725,
-0.021516722,
-0.008912531,
0.0056149615,
-0.0054364414,
-0.010179013,
0.0021338202,
0.014106454,
0.003231887,
0.0070330175,
-0.022634998,
-0.016060071,
-0.0016664681,
0.009269571,
0.0138774095,
-0.0059585287,
-0.014079508,
-0.0020226662,
0.0320393,
0.014618437,
-0.006177468,
0.030745873,
-0.026515285,
-0.008393812,
0.007639312,
0.010199223,
-0.02175924,
0.0082995,
0.022325115,
-0.0059585287,
-0.0045000534,
0.04758739,
-0.032632124,
0.009431249,
0.009640085,
-0.009444723,
-0.0021456091,
0.02231164,
-0.033925552,
0.01492832,
0.014483704,
0.008757588,
-0.0327938,
0.018579561,
0.020600542,
0.007376584,
-0.012543562,
0.004018386,
0.022042178,
-0.0117419055,
-0.03885675,
-0.021435883,
-0.003577138,
0.00506256,
0.0032638859,
0.020452337,
0.0068241823,
0.013850464,
0.0028260066,
0.003108944,
-0.012920812,
-0.0022702364,
-0.0045337365,
-0.029533284,
-0.016585525,
0.002731694,
0.009397566,
-0.011957477,
-0.035650123,
0.0025834886,
0.016343009,
0.016666366,
0.006692819,
-0.00081134005,
-0.0056082252,
-0.020910427,
-0.0049716155,
-0.0052040284,
-0.009761343,
-0.018902918,
-0.014995687,
-0.015736714,
-0.0010037544,
-0.0089933695,
0.035245925,
-0.0074102674,
-0.022325115,
0.0046448903,
-0.013823517,
0.00488404,
-0.0071340664,
-0.003430617,
-0.041605283,
0.021193365,
-0.011802535,
-0.009720923,
0.025060177,
-0.03618905,
0.022325115,
-0.009242624,
0.013850464,
-0.005264658,
0.0014812114,
0.013358691,
0.021166418,
-0.013567526,
-0.020452337,
0.029775802,
0.001132592,
0.011708222,
0.026124561,
-0.009990388,
0.014914847,
-0.008353393,
-0.0038263926,
0.0009987019,
0.013688785,
-0.014645383,
0.025962882,
0.016491214,
-0.006817446,
0.0069454415,
0.028994355,
0.024480829,
0.004274377,
0.040096283,
-0.0085757,
0.0043653212,
-0.010448477,
0.013008388,
-0.0051905555,
0.018875971,
0.001965405,
0.003664714,
-0.004085752,
-0.00504235,
-0.024790712,
-0.024292205,
0.0036950288,
-0.011357919,
0.052437745,
-0.00095070363,
0.007349638,
-0.027997337,
-0.0047728857,
0.02813207,
-0.0046583633,
0.0008559701,
0.0064267227,
0.02293141,
0.009262834,
0.03228182,
-0.019064598,
-0.0018273046,
0.0051366626,
-0.009471669,
0.006793868,
0.0044966848,
0.019051123,
-0.0089057945,
-0.017393919,
0.041443605,
0.013250905,
-0.006547982,
0.028563213,
-0.008872111,
-0.011162558,
0.016841516,
0.0005911372,
0.01723224,
0.011364656,
0.016625945,
0.0019317219,
-0.0049581425,
0.026757801,
-0.010994142,
-0.008137821,
0.010131856,
-0.005443178,
0.015601981,
-0.0073092184,
0.011647593,
0.022608053,
0.010549526,
0.019024177,
0.021287678,
-0.0077201515,
0.016666366,
-0.022648472,
-0.0145780165,
0.014079508,
-0.002098453,
-0.02150325,
-0.0069387048,
-0.011647593,
0.00865654,
-0.0031914674,
0.015413356,
0.011789062,
-0.0098421825,
0.010893093,
0.026420971,
-0.002841164,
-0.030233892,
-0.007807727,
0.01459149,
0.014443285,
0.0023173927,
-0.004085752,
0.00978829,
-0.0069319685,
-0.009491879,
0.009923021,
0.00064460904,
-0.0163969,
-0.0097546065,
-0.011405075,
0.014901374,
-0.024009267,
0.02507365,
-0.026690437,
-0.009047262,
-0.024750292,
0.02130115,
-0.009202205,
0.00034777733,
-0.019967303,
0.008784535,
0.022890989,
-0.0041295397,
-0.015750187,
-0.0036175577,
-0.034787837,
0.024655981,
0.015777133,
-0.002696327,
-0.00235276,
0.033817764,
-0.013722468,
-0.008609383,
-0.005951792,
0.009464933,
0.008703696,
-0.018417882,
-0.035057303,
0.0009877549,
0.017703803,
0.06644989,
0.028509319,
-0.013493423,
0.027229365,
0.0109806685,
0.010051018,
-0.030880606,
-0.024925444,
0.017286133,
-0.016572053,
-0.022123016,
0.007450687,
-0.0017237292,
0.010179013,
0.010569735,
0.018269677,
0.005961897,
-0.019886462,
-0.00009257571,
-0.010205959,
-0.010852673,
-0.00095996645,
0.022823624,
0.0135271065,
0.014793588,
0.0021691874,
0.026744328,
0.012839972,
0.011997896,
-0.0038567074,
0.0008740747,
-0.0060157897,
-0.0059248456,
-0.0042777453,
-0.024507776,
0.023160454,
0.008723905,
-0.01953616,
0.007706678,
0.0036916605,
0.028024284,
0.015130418,
0.0065816646,
0.0056688543,
-0.009976914,
-0.027148524,
0.020048141,
0.031096177,
-0.006396408,
-0.018646928,
0.02372633,
-0.024965864,
-0.009101155,
-0.03166205,
0.0030921025,
-0.0014483704,
0.005123189,
0.0138774095,
0.023335606,
-0.015413356,
-0.036674086,
-0.008851902,
0.0034828256,
-0.013055543,
-0.04297955,
-0.019657418,
-0.029102141,
-0.0029253715,
-0.0011789062,
0.0080569815,
0.009734397,
0.00397123,
-0.021152945,
-0.005985475,
0.0015081578,
0.0072014327,
0.025370061,
-0.025275748,
0.0022062387,
0.0015233152,
-0.03136564,
-0.02934466,
0.02171882,
-0.041443605,
0.008191714,
0.04025796,
-0.020977793,
-0.028293747,
-0.015332517,
0.014793588,
-0.012583981,
-0.00041577494,
-0.005254553,
-0.0072755353,
0.0075382628,
-0.0005397706,
0.0029186348,
0.021907445,
0.0022264486,
-0.022688892,
0.004718993,
-0.004062174,
0.015992705,
-0.0011048035,
-0.0007961827,
-0.0003875654,
-0.029533284,
0.009667031,
-0.006197678,
-0.02276973,
0.0023443392,
-0.023483811,
0.0048335153,
0.0037051337,
0.011829481,
0.011472441,
-0.020182874,
0.026434444,
0.022123016,
-0.03400639,
-0.011607173,
-0.01840441,
0.029883588,
0.015009159,
-0.018377462,
0.03492257,
-0.026488338,
-0.032093193,
-0.015440303,
-0.005086138,
-0.014537597,
0.02993748,
0.002797376,
-0.0074574235,
-0.024494302,
-0.003295885,
-0.00012231151,
-0.00859591,
-0.007834674,
-0.0013540579,
-0.017178347,
-0.004944669,
-0.0058473744,
-0.0032453602,
0.034060284,
-0.030018318,
-0.008131084,
0.0037657632,
-0.008400548,
0.034518372,
-0.0017296238,
-0.01163412,
-0.0053589707,
-0.0039476515,
-0.022715839,
-0.050551496,
0.0027485355,
0.0003275675,
0.036269892,
0.0011359603,
0.019738257,
-0.014887901,
-0.009734397,
0.03734775,
-0.0027384306,
0.01957658,
0.011034561,
0.013810044,
-0.01949574,
0.018148419,
-0.0056520132,
0.006743343,
0.0275123,
-0.009653557,
0.023079615,
0.0066153477,
-0.0085757,
-0.00939083,
-0.0046785735,
-0.04591671,
0.0043013236,
-0.00131027,
-0.01806758,
0.0052478164,
-0.042036425,
-0.004516895,
0.002952318,
0.018188838,
-0.0060562096,
-0.021920918,
0.014092981,
-0.0048133056,
0.005254553,
0.0056553814,
0.017286133,
-0.0037724997,
0.0019586685,
-0.023645489,
-0.0022483424,
0.029075194,
0.018646928,
0.013580999,
0.01731308,
-0.011768851,
-0.0070869103,
0.012752396,
0.010354164,
0.022904463,
0.00093133585,
0.0015342622,
0.005806955,
-0.010394584,
-0.021920918,
0.016343009,
-0.012947758,
-0.0007717625,
0.0032891482,
0.017717276,
-0.01915891,
-0.036889657,
-0.0036916605,
-0.0068982854,
0.028374588,
-0.009835445,
-0.0003153574,
0.019051123,
0.002553174,
-0.006517667,
0.017892428,
0.006972388,
0.0017397287,
0.01459149,
0.014254659,
-0.018795133,
-0.016275642,
0.012637874,
0.00014094244,
-0.00968724,
-0.010549526,
0.014712749,
0.026609596,
-0.015857972,
-0.009107892,
-0.0019940357,
-0.021220312,
0.022432901,
-0.021826606,
0.0016841517,
-0.009027053,
-0.019630471,
0.0076797316,
0.0269599,
-0.00066902925,
0.037132178,
0.013971723,
-0.01492832,
0.005153504,
0.0075315265,
-0.030368622,
0.015467249,
-0.0041665914,
0.021368517,
-0.02100474,
0.0019233013,
-0.0133519545,
0.012711977,
0.008306236,
0.00233255,
-0.026124561,
0.026474865,
-0.013904356,
-0.0071879593,
0.023429917,
0.006595138,
-0.0038263926,
0.013244169,
-0.0036276628,
-0.037266906,
0.004567419,
0.017070562,
0.0042339573,
0.010839201,
-0.022284694,
0.01764991,
-0.0075921556,
-0.022688892,
-0.008804745,
-0.02427873,
0.000432827,
-0.014402865,
0.007693205,
0.0014382655,
0.00031851517,
0.017137928,
0.027808713,
0.0036815556,
0.027027266,
-0.003664714,
-0.028374588,
0.009464933,
0.0077740443,
0.006106734,
-0.02062749,
-0.011539808,
-0.02813207,
-0.004894145,
0.036000427,
-0.015871445,
-0.04419214,
-0.013749414,
-0.015089999,
0.027997337,
-0.002376338,
-0.025167963,
-0.009916285,
0.0070464904,
0.00017094139,
-0.015009159,
-0.021072106,
0.005274763,
-0.03462616,
0.024629034,
0.005318551,
-0.0007595524,
-0.008858638,
-0.020075088,
0.016154382,
0.0008517597,
-0.03462616,
-0.0064772475,
-0.010751625,
0.019778676,
-0.018134946,
-0.025572158,
0.016167857,
-0.012570508,
-0.016989723,
0.010576473,
0.027444936,
-0.009114629,
-0.007396794,
-0.030557249,
-0.0064233546,
0.031500373,
-0.006686082,
-0.011458968,
0.003053367,
-0.006039368,
-0.0029641069,
-0.012321253,
-0.013998669,
0.046051443,
0.027094632,
-0.0098421825,
-0.022298168,
-0.045808926,
-0.039853767,
0.0019115121,
-0.010583209,
0.0037489217,
0.01050237,
0.0064705107,
0.007753834,
0.0068949168,
0.009855656,
-0.01383699,
0.0171514,
-0.031689,
0.02444041,
-0.0070801736,
0.031096177,
0.00021851867,
-0.05030898,
0.007470897,
0.011344446,
-0.017528651,
-0.019401427,
0.006238098,
-0.003231887,
-0.0135271065,
-0.00970745,
0.018161891,
-0.009067473,
0.005722747,
-0.002378022,
-0.031877622,
-0.0019165647,
-0.010475423,
0.02293141,
-0.013385638,
-0.002996106,
0.006743343,
0.0006126102,
0.006359357,
-0.025855096,
-0.022648472,
-0.00009473353,
-0.008252343,
0.0046280487,
0.019751731,
0.006329042,
0.04025796,
-0.020411918,
-0.00012789026,
-0.0038364974,
0.027444936,
-0.003529982,
-0.008454441,
0.02616498,
-0.016060071,
-0.015588508,
-0.014066035,
-0.02797039,
-0.03166205,
0.013035334,
-0.0004353532,
-0.004476475,
-0.0025565422,
0.024790712,
0.014119928,
-0.028266802,
0.010630365,
-0.043787945,
-0.014160347,
0.0017801484,
-0.02783566,
0.0010803833,
-0.01764991,
0.022796677,
0.00094228284,
-0.014497178,
0.0068342877,
0.010333954,
-0.009296517,
-0.0254509,
-0.0085824365,
0.19767898,
-0.018970285,
0.0019367745,
0.0145780165,
-0.02100474,
-0.008811481,
0.052222174,
0.007019544,
-0.016046597,
0.019401427,
0.015911864,
0.00064039865,
-0.025666472,
0.0033059898,
0.023834115,
-0.0128534455,
-0.034060284,
-0.022608053,
0.005338761,
-0.010071227,
0.0006197678,
-0.0010820675,
-0.020384971,
0.0021472934,
0.030665034,
0.009296517,
0.0052680266,
0.007908776,
0.023120034,
0.0062785177,
-0.016962776,
-0.018593034,
0.0068982854,
-0.02372633,
-0.020735275,
-0.015467249,
-0.004752676,
-0.006881444,
0.006861234,
0.012361674,
-0.024426935,
0.0050086672,
0.0065210355,
-0.010152066,
0.0059147407,
0.03257823,
-0.001288376,
0.015319044,
-0.034248907,
0.0042811134,
-0.036701035,
-0.0026862219,
0.027188944,
0.002241606,
-0.016706785,
-0.01350016,
0.020667909,
0.011135611,
0.008939477,
-0.0047762543,
-0.007652785,
-0.009902812,
-0.011795798,
0.014402865,
-0.023753274,
0.026528757,
-0.011290553,
0.005342129,
-0.014524124,
-0.020102035,
-0.0032891482,
-0.0051804506,
-0.031177016,
0.016787624,
-0.011748642,
-0.03220098,
0.025976356,
0.039934605,
0.0012252204,
0.02767398,
-0.02221733,
-0.008926004,
-0.012395356,
0.008339919,
-0.03785973,
-0.029694961,
0.02658265,
0.004853725,
0.014712749,
0.0011848008,
-0.009808499,
0.021489775,
-0.0158445,
-0.032605175,
0.0004921933,
-0.008865374,
0.019846043,
0.0025969618,
-0.014429811,
-0.012051789,
-0.030530302,
0.0738871,
-0.005076033,
-0.016154382,
0.023173926,
0.0011410128,
-0.013810044,
0.026879061,
0.003620926,
-0.012637874,
0.0040453323,
-0.03815614,
0.0075382628,
-0.00010531211,
0.011452232,
0.008387076,
0.008158031,
-0.00048587777,
0.016585525,
-0.026232347,
0.0072553256,
-0.019131962,
0.009559245,
0.02306614,
0.006972388,
0.013695521,
-0.00008557596,
-0.011263606,
-0.0009473353,
0.0002543069,
0.0073698475,
-0.02175924,
0.017070562,
0.010199223,
0.008326446,
0.0016504687,
-0.00023178138,
-0.024831133,
0.00393081,
-0.0024335992,
-0.02590899,
-0.014887901,
0.0013793202,
-0.026084142,
0.015265151,
-0.018040633,
0.012819762,
-0.016275642,
0.007396794,
0.017501704,
-0.000622294,
-0.009862392,
-0.009215678,
0.0048267785,
0.017636437,
-0.002698011,
-0.010381111,
-0.037698053,
-0.0103676375,
0.03723996,
-0.016531633,
0.018741239,
0.020142455,
0.0020294026,
-0.010657311,
0.0065884013,
-0.17148706,
0.009491879,
0.029506337,
-0.0056587495,
0.02541048,
-0.006561455,
0.022877516,
0.020735275,
-0.024588615,
-0.011202977,
0.009923021,
0.002233185,
-0.0105427895,
-0.03198541,
-0.0033952498,
0.01264461,
-0.04206337,
0.018673874,
0.016316062,
0.021058632,
0.02113947,
-0.013338481,
0.022877516,
-0.017286133,
0.018471776,
-0.003430617,
-0.0073900577,
0.0045472095,
-0.019199328,
-0.02239248,
0.016248696,
0.011849691,
0.022257749,
0.014820535,
0.024130525,
0.021355044,
-0.0071677496,
0.012233677,
-0.001698467,
0.01832357,
0.011357919,
0.014092981,
-0.047560442,
-0.020789169,
0.0010071227,
0.017744223,
0.02179966,
0.004560683,
0.00042545883,
-0.0053219195,
-0.01568282,
-0.01588492,
0.025343115,
-0.005251185,
0.016167857,
0.029371604,
0.017852008,
-0.0028512687,
-0.0020243502,
-0.014807061,
-0.008036772,
-0.009134838,
0.024251783,
0.010374375,
-0.032470442,
-0.025006283,
0.0048773033,
-0.04403046,
-0.018417882,
0.005076033,
-0.03309021,
-0.009047262,
0.0040284907,
-0.017218767,
0.008986633,
0.032443497,
-0.005396022,
-0.0040722787,
0.0051568723,
0.013850464,
-0.0011746958,
0.0013271115,
-0.023335606,
0.003164521,
-0.009027053,
0.03236266,
-0.015440303,
0.008804745,
-0.0060764193,
-0.019590052,
0.022149963,
-0.029452445,
0.0013692153,
-0.0037152385,
0.00094901945,
0.0025060177,
0.004476475,
-0.0016285747,
-0.0012454302,
-0.029398551,
0.0012294307,
0.009714187,
-0.007908776,
0.009471669,
0.0052276067,
-0.018552614,
-0.0040924884,
-0.005493703,
0.033036318,
-0.016760677,
-0.024103578,
-0.004607839,
0.010118383,
0.0074911066,
0.016585525,
0.021287678,
0.0047324663,
-0.012806289,
-0.0033699875,
-0.0074102674,
0.073186494,
0.014847481,
0.00051661354,
0.024467355,
0.0021068738,
-0.017771168,
-0.10945638,
-0.01806758,
0.006315569,
-0.0072216424,
0.0063930396,
0.03287464,
-0.014012142,
0.018094525,
0.00055450696,
0.034221962,
-0.003396934,
-0.0065311403,
-0.014227713,
-0.040365748,
0.013776361,
-0.0020176137,
0.0076460484,
-0.03996155,
0.004395636,
0.04443466,
-0.011324236,
-0.00054145476,
0.026191927,
-0.020762222,
-0.008070455,
-0.02549132,
-0.014564544,
0.0239419,
0.0029876851,
0.010765097,
0.013042071,
-0.002553174,
-0.018471776,
-0.017057087,
-0.014146874,
0.000777657,
-0.016208276,
-0.016060071,
0.02729673,
-0.021732293,
0.0036916605,
0.007450687,
0.029829694,
-0.016356481,
-0.0070464904,
0.009956704,
-0.0038701806,
0.017286133,
-0.018269677,
0.003708502,
-0.015831025,
-0.010219432,
0.012577245,
-0.007875093,
0.008454441,
-0.0063930396,
0.0027182207,
-0.00577664,
-0.01127708,
-0.0027771662,
-0.017340025,
0.0123482,
-0.0014492125,
0.011714959,
-0.0077268877,
-0.01312291,
-0.01226736,
-0.013028597,
0.006450301,
-0.01983257,
-0.009491879,
0.008414022,
-0.0017228872,
0.0043720575,
-0.033198,
-0.023955373,
-0.027552722,
-0.030368622,
0.0025683313,
-0.00052208704,
-0.012880392,
-0.0147262225,
0.026744328,
-0.012819762,
-0.0077673076,
-0.010792044,
0.017596018,
0.0013136383,
-0.0048267785,
-0.015575035,
0.0010096489,
0.035326764,
0.0029590544,
-0.004463002,
-0.016787624,
0.011869901,
-0.00224329,
-0.03966514,
0.007888567,
-0.022082597,
-0.002076559,
0.0034053547,
-0.049716156,
0.029021302,
-0.005918109,
-0.01492832,
0.018943338,
0.020708328,
0.015548089,
-0.015319044,
-0.01673373,
-0.0124155665,
-0.02247332,
0.025882043,
-0.04653648,
-0.008629593,
-0.0019131963,
-0.012759133,
0.024669454,
0.01429508,
0.016491214,
0.025370061,
0.00009704924,
0.0069387048,
0.0152247315,
0.0066355574,
-0.0061471537,
0.0024133893,
0.0020496126,
0.0033346203,
-0.02528922,
-0.01764991,
0.013473214,
-0.00867675,
-0.0041126986,
0.00279906,
-0.01155328,
-0.0067096604,
0.0080300355,
0.028859623,
0.028778784,
0.009990388,
-0.01903765,
-0.0312848,
0.021166418,
-0.004756044,
-0.0011586964,
0.005409495,
-0.038883694,
0.010637102,
-0.010562999,
-0.01429508,
0.027943445,
0.011054772,
-0.033036318,
-0.023241293,
-0.003977966,
0.00067787105,
-0.0018778291,
0.022944883,
-0.02574731,
-0.043760996,
0.041039407,
-0.007740361,
0.002863058,
0.0031291537,
-0.0025026493,
0.00013631102,
-0.026232347,
0.017852008,
0.022298168,
-0.03090755,
-0.032012355,
0.0173535,
-0.0024959128,
0.020667909,
0.017461285,
0.0072890082,
0.0076864683,
0.03915316,
-0.012226941,
0.009869128,
0.020155927,
0.0077336244,
-0.014564544,
-0.0035636649,
0.0410933,
0.0074978434,
-0.01274566,
0.01199116,
0.00895295,
-0.017973267,
-0.0037118702,
0.010866147,
0.015655873,
0.013277852,
0.0061909417,
0.03198541,
-0.022634998,
0.019185856,
0.021624507,
0.01669331,
0.019886462,
0.006692819,
0.008838428,
-0.017825061,
-0.02276973,
0.0030483145,
-0.04591671,
-0.035946533,
-0.010091437,
0.0076325755,
0.0025262276,
-0.011243396,
-0.033009373,
0.0110412985,
-0.020681383,
-0.0132643785,
-0.015063053,
0.030584194,
-0.011344446,
0.008353393,
0.0030718925,
-0.0030685244,
0.022958355,
-0.009323464,
0.00026272767,
0.018269677,
0.012139365,
-0.03400639,
0.028159017,
0.005406127,
0.03489562,
-0.0077740443,
0.0060461047,
0.015453775,
0.011472441,
-0.01987299,
-0.007747098,
0.011364656,
0.008872111,
0.05739589,
0.0035165087,
-0.012146102,
-0.0009085998,
-0.027808713,
-0.0097546065,
0.028967408,
0.009060736,
0.005443178,
0.005123189,
-0.008467915,
0.020425392,
0.027943445,
-0.017245714,
-0.020411918,
-0.0040049125,
0.010394584,
0.005864216,
-0.006696187,
-0.022298168,
0.009795026,
-0.006504194,
0.012839972,
-0.008225397,
-0.018997231,
-0.020384971,
-0.026286239,
-0.0100173345,
-0.02025024,
0.0044528972,
-0.005628435,
0.021813132,
-0.029775802,
-0.016585525,
0.024426935,
-0.020411918,
0.0031813625,
-0.0068881805,
0.0020159294,
-0.016787624,
0.012914075,
0.010987406,
-0.011869901,
-0.01832357,
0.00052040286,
-0.025087124,
-0.016167857,
0.014106454,
-0.025167963
] |
BACKGROUND More than 2 million U.S. women receive an equivocal cervical cytologic diagnosis (atypical squamous cells of undetermined significance [ASCUS]) each year. Effective colposcopy triage strategies are needed to identify the minority of women who have clinically significant disease while avoiding excessive follow-up evaluation for others. METHODS The ASCUS/LSIL (i.e., low-grade squamous intraepithelial lesion) Triage Study (ALTS) is a multicenter, randomized trial comparing the sensitivity and specificity of the following three management strategies to detect cervical intraepithelial neoplasia grade 3 (CIN3 | [
-0.011764315,
0.01661168,
0.026746456,
-0.04504956,
-0.02086086,
0.002213974,
-0.03440598,
-0.0037197513,
-0.01916944,
-0.01432895,
0.025151296,
0.016927963,
-0.021204645,
0.02491752,
-0.006280948,
0.0029995223,
0.032865826,
0.0069719553,
0.0011301924,
-0.015759094,
-0.044444498,
0.0079483045,
-0.0168042,
0.0057549574,
-0.01846812,
0.016817952,
0.0061881263,
-0.037128758,
-0.006748495,
-0.006961642,
0.015044022,
0.009020912,
-0.0019956706,
-0.0032367338,
-0.010196657,
0.014672735,
0.028272862,
0.00008959891,
0.02015954,
-0.004974566,
0.017491769,
-0.01809683,
-0.0067450576,
-0.027956579,
-0.010547318,
0.009110297,
-0.0064219,
-0.00096689473,
-0.01739551,
0.010726085,
0.0039500874,
-0.0046961,
-0.028547889,
0.0048439275,
-0.0043282504,
0.004592965,
0.014658983,
0.00074687245,
-0.0015195288,
-0.00289123,
-0.0040360335,
-0.005820276,
-0.009949132,
0.026911473,
-0.00664536,
0.0076388977,
-0.013820148,
0.009034664,
0.01562158,
0.0040600984,
0.020297054,
0.03509355,
-0.0011327709,
-0.011592423,
0.030968133,
-0.019691993,
-0.022786055,
-0.017340504,
0.0057308925,
0.010753588,
0.01817934,
-0.010182905,
-0.010980486,
-0.006342829,
0.011207384,
0.03960401,
0.01639166,
0.023652393,
-0.019595733,
-0.002078179,
0.011970586,
0.015222791,
0.03410345,
0.01896317,
-0.02857539,
0.01146866,
-0.0079620555,
0.035313573,
0.007886423,
-0.031793218,
0.0032951771,
0.0016286804,
-0.0038538275,
-0.0077626603,
-0.028932927,
-0.017711792,
0.0011009708,
0.01819309,
0.03014305,
-0.007274486,
-0.019746998,
0.02915295,
0.015470316,
-0.010251663,
0.040951643,
-0.02086086,
0.013978289,
0.035726115,
-0.027599042,
0.003994779,
0.005215215,
0.012417506,
0.03589113,
-0.03193073,
0.02282731,
-0.0017300969,
-0.029950531,
-0.0005410313,
0.0018323729,
-0.019746998,
0.026361417,
-0.0070682154,
-0.0009144675,
0.019251948,
-0.01877065,
-0.023693647,
-0.0110973725,
-0.00010313543,
-0.021878464,
-0.019004423,
0.0014155338,
0.03963151,
0.0007245264,
0.004582651,
-0.002824192,
0.0056655733,
0.021520928,
-0.00415292,
-0.030088045,
0.01033417,
0.0004439121,
-0.027791562,
0.021685945,
-0.007996434,
0.0014052204,
0.009625974,
0.01106987,
0.023693647,
-0.019031925,
-0.02501378,
-0.02786032,
0.005713703,
0.0030012412,
0.0041151037,
0.007817666,
0.021218397,
0.01279567,
0.016089128,
-0.01602037,
-0.024573736,
-0.0021400603,
0.024188697,
-0.019114435,
0.014768994,
-0.0077420333,
-0.008113321,
0.0061881263,
0.014645232,
-0.018798152,
-0.02798408,
-0.016487919,
0.03154569,
0.023267355,
0.002306796,
-0.042849336,
-0.00038267544,
0.024931272,
0.008058315,
-0.011991213,
-0.016171636,
-0.011839948,
0.03193073,
-0.008952156,
-0.0003680646,
-0.6279435,
-0.028547889,
0.016432913,
0.004720165,
0.024958774,
0.027145246,
0.012279993,
0.0017739295,
-0.00600592,
0.0052014636,
-0.007659525,
-0.0029651439,
-0.001039949,
0.029097944,
-0.0041185417,
-0.03506605,
-0.02361114,
-0.010155402,
0.009041539,
-0.015154033,
-0.007913926,
0.02103963,
0.0026471429,
0.002420245,
0.015635332,
0.017257996,
0.0052908477,
-0.037816327,
-0.026650196,
0.003547859,
-0.016529173,
0.010822345,
-0.012713161,
-0.0029995223,
0.04969753,
-0.011826197,
-0.026883971,
-0.003183447,
0.016927963,
0.02392742,
-0.020723347,
-0.0064047105,
0.013820148,
-0.0039707143,
-0.008656501,
0.045984652,
-0.012445009,
0.00785892,
0.015992869,
-0.02084711,
0.0077420333,
0.0028173162,
0.0022947635,
0.009969759,
0.037321277,
0.0035100426,
0.026375169,
-0.014865254,
0.0037163135,
-0.01798682,
-0.014438961,
-0.00078984554,
-0.0049608145,
-0.018399362,
-0.014645232,
0.04031908,
0.00781079,
0.008725258,
0.017257996,
0.004864555,
0.026815213,
0.018798152,
-0.015676586,
-0.001399204,
0.008072067,
0.02282731,
-0.010457933,
0.0006063504,
0.008505235,
-0.012768167,
0.022112237,
0.008312716,
0.0042732446,
0.0076664006,
-0.0077214064,
-0.0026763645,
-0.015497818,
0.011056119,
-0.009907877,
0.016171636,
0.0050673876,
0.00013998487,
-0.0030648413,
-0.035616104,
0.0005242718,
0.007879547,
-0.02282731,
-0.0005036447,
0.028149098,
-0.035313573,
-0.0010820626,
-0.0037335027,
-0.027709054,
0.024367465,
0.025838865,
-0.020118285,
-0.02311609,
-0.0062740725,
0.03707375,
-0.042244274,
0.032370776,
-0.010664204,
-0.009481585,
-0.02362489,
0.019320704,
-0.01688671,
-0.006710679,
0.014074549,
-0.026127644,
-0.015937863,
0.01305007,
0.0014353015,
0.0051842746,
-0.01710673,
-0.011406779,
0.002323985,
0.016556675,
0.011283017,
0.002844819,
-0.017436765,
-0.026416423,
-0.026457677,
0.010870475,
-0.022194745,
0.0067381817,
-0.0375413,
0.027158998,
-0.013297595,
-0.01937571,
-0.031380676,
-0.033333372,
-0.018055577,
0.009901002,
0.006349705,
0.0028345056,
-0.0058615305,
-0.03190323,
0.012355625,
0.009763488,
-0.00076449144,
-0.029427977,
-0.014342701,
-0.0062018777,
0.020338308,
-0.010602322,
-0.0017524429,
0.01196371,
-0.02312984,
0.00600592,
-0.02381741,
-0.009282189,
0.012293744,
-0.0069753933,
-0.009124048,
0.010361673,
0.0064700297,
-0.0025680724,
0.0054180482,
-0.023556134,
-0.007295113,
-0.018440615,
-0.012940059,
-0.0016295399,
0.036826227,
-0.016144134,
-0.007817666,
-0.0052770963,
0.002910138,
0.0047648572,
-0.0058890334,
0.011496163,
0.0123968795,
-0.0014404582,
0.0030992199,
0.0061090556,
0.018825654,
0.017079229,
-0.027131496,
0.0023377365,
0.008223332,
-0.008429603,
-0.0004580932,
-0.0052805343,
0.0147414915,
0.0000024961328,
0.019691993,
-0.007797039,
0.010196657,
0.00083840516,
0.02846538,
0.030720608,
-0.0029273275,
0.034681007,
-0.011296768,
0.010361673,
-0.019691993,
0.007893299,
-0.002867165,
0.018701892,
0.0013820148,
0.018619385,
-0.008168327,
-0.00261964,
0.0015392964,
-0.025481328,
0.018839406,
0.024243703,
-0.004881744,
0.0046273433,
0.0057515195,
-0.010712334,
-0.008670252,
0.037706316,
-0.00055091514,
0.007480757,
0.025948875,
0.032838322,
0.008037688,
0.0067863115,
-0.0035444212,
-0.009852872,
0.020242048,
0.0032298581,
0.013565748,
0.021727199,
0.012314371,
0.033828422,
-0.0059302878,
0.01531905,
-0.017546775,
-0.0050055063,
0.002279293,
0.001436161,
-0.006167499,
0.022222249,
-0.012788794,
0.05803087,
0.02669145,
-0.014095176,
0.005689638,
-0.0035100426,
0.007728282,
-0.013586375,
0.0061606234,
-0.023061084,
-0.013840775,
0.003389718,
0.04785484,
0.039576504,
0.016185388,
0.013208211,
-0.006390959,
0.007542638,
0.008161451,
-0.016364155,
0.01052669,
0.012905681,
-0.011441157,
-0.014713989,
-0.024298709,
-0.020888364,
-0.02816285,
0.008615247,
-0.02461499,
0.007797039,
0.0070819664,
0.0034756642,
0.0017997134,
0.023377365,
0.0007202291,
-0.015882857,
-0.056490716,
0.023226101,
0.036138657,
-0.010066018,
-0.0059715416,
0.007817666,
-0.0013923284,
0.009062167,
0.016350405,
0.02400993,
0.020187043,
-0.01531905,
0.012871303,
-0.0043901317,
0.0103135435,
0.011324271,
-0.010347922,
0.010863599,
0.020187043,
0.00223632,
-0.021108385,
-0.0058924714,
-0.0034653507,
0.026141396,
0.004149482,
-0.017147984,
-0.001739551,
-0.017120482,
-0.009240935,
-0.012685658,
-0.01255502,
-0.026883971,
0.013730764,
0.012114976,
0.026306411,
0.00464797,
-0.0057721464,
0.03745879,
0.0084846085,
-0.00255604,
-0.039301477,
-0.0058099627,
-0.02183721,
0.030693106,
0.030033039,
0.001333885,
0.023391116,
0.0076664006,
0.0038125732,
0.0048473654,
-0.036413684,
0.0061571854,
-0.010017889,
-0.019540727,
0.029372972,
0.021204645,
0.0065731653,
0.035616104,
0.04301435,
0.003706,
-0.010533566,
0.013662008,
-0.0116130505,
0.0026712078,
-0.0030940631,
0.026540186,
0.028245358,
0.013916408,
-0.020434568,
0.018743146,
0.004837052,
-0.020297054,
0.00084657,
-0.0405116,
0.034653507,
-0.004266369,
0.024573736,
-0.02351488,
0.00023377365,
0.017821804,
-0.004286996,
-0.019004423,
-0.00983912,
0.002825911,
0.0116061745,
0.009130924,
0.0074945083,
-0.008010185,
-0.022854812,
0.00392946,
0.03270081,
0.0147414915,
-0.01442521,
0.039466493,
-0.012094349,
0.0076388977,
-0.016625432,
0.012376253,
0.001707751,
-0.0038607032,
-0.013414483,
-0.01690046,
-0.016006619,
-0.0055624377,
-0.01338698,
0.003458475,
-0.012004965,
-0.028121596,
-0.02776406,
-0.025756355,
-0.0071713505,
-0.027048986,
0.011001113,
-0.0036063024,
-0.021974724,
-0.02154843,
0.014989017,
-0.00025354128,
0.0008555944,
0.0053458535,
0.0012470793,
0.00305109,
0.04455451,
-0.01423269,
0.006751933,
-0.0018890974,
-0.03371841,
0.018261848,
-0.00053759344,
-0.005400859,
0.0033020528,
-0.037898835,
0.01729925,
0.023391116,
-0.0051567717,
-0.017808052,
-0.01670794,
0.0009127486,
0.004947063,
0.015374055,
0.0016114912,
-0.0090002855,
-0.034928534,
-0.00019123028,
-0.055693135,
-0.01896317,
-0.017560527,
-0.00519115,
-0.00415292,
-0.009914753,
0.008237083,
-0.006714117,
-0.022978576,
0.00088008906,
-0.011846824,
0.01729925,
-0.012864427,
-0.015649084,
0.030225558,
-0.022992326,
0.019609485,
0.02984052,
0.00958472,
0.00484049,
-0.005521184,
0.027626546,
0.0034928534,
-0.016144134,
0.037211265,
-0.010884226,
-0.0147414915,
-0.031380676,
-0.021479674,
0.0060231094,
0.02798408,
0.0020455194,
-0.024642494,
-0.02341862,
0.0028104407,
0.000915327,
0.01838561,
-0.017092979,
-0.019554479,
0.022786055,
0.023721151,
-0.023679895,
-0.0073363674,
0.024972526,
-0.020792104,
0.0077214064,
0.0306381,
-0.031848222,
0.0040532225,
-0.011014865,
-0.014906508,
-0.00993538,
-0.01007977,
0.0057240166,
-0.020434568,
0.0009875218,
-0.011413655,
0.0405116,
0.031573195,
0.023281105,
0.0031748526,
0.0022724175,
0.020902114,
-0.019802004,
0.016501669,
-0.0306381,
0.009969759,
-0.01701047,
0.02797033,
0.0029754573,
-0.00056681514,
0.011317395,
-0.0082302075,
0.007927678,
0.03330587,
-0.020654589,
-0.03322336,
-0.025316311,
-0.034323473,
-0.02519255,
-0.008512111,
0.0067863115,
0.0197745,
-0.051842745,
-0.0032607988,
0.015566575,
0.008697755,
-0.0049092467,
-0.009302816,
0.050962657,
-0.0036097402,
0.0014877287,
-0.011111124,
0.01896317,
-0.018825654,
-0.022497276,
-0.011276141,
0.026416423,
0.017409261,
0.00083067,
0.024463726,
0.0365512,
-0.015539072,
0.00081476994,
0.035121053,
-0.014273944,
-0.001875346,
0.00560713,
-0.022854812,
-0.0014928854,
-0.0057308925,
-0.016336653,
-0.01571784,
0.007920802,
0.00051095017,
-0.0044451375,
0.01888066,
-0.018124335,
0.0019544165,
0.005249594,
0.006260321,
0.010808594,
-0.029317966,
0.03388343,
0.0033501827,
0.009701607,
-0.02174095,
0.0024443099,
-0.004039471,
0.013524493,
0.013572623,
0.02857539,
-0.011028616,
0.016584178,
-0.0051602097,
0.023074836,
-0.00015405855,
-0.03737628,
0.0029170138,
0.0158141,
0.029207956,
-0.028382871,
-0.02084711,
-0.008072067,
0.024766255,
0.006016234,
-0.0064631538,
0.0032212634,
0.0061778123,
0.009722234,
0.027282761,
-0.017753046,
0.025041284,
-0.015786598,
0.003726627,
0.0024288394,
-0.044306982,
-0.0071232207,
0.010506063,
-0.0004314499,
0.0017206429,
0.00018961879,
0.007700779,
-0.014301447,
0.0049608145,
0.009962883,
0.0019148813,
-0.014645232,
0.03875142,
-0.009337195,
-0.0023635204,
0.0004606716,
0.0046376567,
0.0054180482,
-0.014507717,
-0.0038607032,
-0.010203533,
-0.030968133,
-0.0010794842,
0.05503307,
0.0065869163,
-0.0168042,
-0.011441157,
-0.008092694,
0.01033417,
-0.029868022,
0.00016695049,
0.025247555,
-0.01690046,
-0.013111952,
0.000492042,
-0.00963285,
0.023954924,
0.013744515,
0.00048172844,
-0.006280948,
0.013772018,
-0.015896609,
0.022070983,
0.02798408,
0.012376253,
-0.016872957,
0.016061625,
-0.011791818,
-0.024587488,
-0.0006514722,
-0.0040119686,
-0.013490115,
-0.01897692,
0.0041082283,
-0.01329072,
0.0032350149,
-0.038283873,
0.0073776213,
0.015140282,
0.017560527,
-0.011145502,
-0.028932927,
0.013868278,
-0.024766255,
-0.0012771605,
0.023198597,
-0.016047874,
0.017092979,
-0.0044210725,
0.011056119,
0.008628998,
-0.04004405,
-0.0038916438,
-0.006016234,
-0.0082302075,
-0.008182078,
-0.003547859,
0.0017292375,
0.023363614,
-0.012390004,
0.00048473655,
0.017147984,
-0.0033501827,
-0.01769804,
-0.017656786,
-0.01896317,
0.018619385,
-0.013462612,
-0.011035492,
-0.0042732446,
-0.022676045,
-0.021149639,
-0.0076870276,
-0.014287695,
0.02402368,
0.018014323,
-0.0072194804,
-0.020627087,
-0.010959859,
-0.02135591,
-0.023281105,
-0.0074945083,
0.0016639184,
0.022799807,
0.01571784,
-0.0049161226,
0.0071438476,
-0.01333885,
-0.01789056,
-0.040456593,
0.0010743275,
0.020145789,
0.01047856,
0.038613908,
0.00042973098,
-0.02876791,
-0.012390004,
0.0246975,
0.007728282,
-0.018660638,
0.030088045,
-0.008807766,
0.004317937,
0.0105679445,
-0.0071438476,
-0.0129125565,
0.008250834,
0.004335126,
-0.024491228,
0.029042939,
0.0014181122,
0.016914211,
0.0027915325,
0.005768709,
-0.023198597,
0.0063359537,
-0.00039900522,
-0.01102174,
-0.024271205,
-0.016460415,
-0.021163391,
0.0016888428,
0.020242048,
0.0057790224,
0.01720299,
-0.000095292846,
0.0061812503,
-0.0074670054,
0.012898806,
-0.015209039,
-0.011977462,
0.011558045,
-0.018605633,
-0.021465922,
-0.0047717327,
-0.015016519,
0.00311469,
-0.014053922,
-0.006170937,
-0.0056758868,
-0.05002756,
0.03536858,
-0.008340219,
-0.01688671,
-0.007852045,
0.02590762,
-0.010870475,
0.0008547349,
-0.008628998,
0.01897692,
-0.049257483,
0.020929618,
-0.0045723375,
-0.0074738814,
0.004314499,
-0.015649084,
-0.0014490528,
-0.023473626,
0.0100591425,
0.19306953,
0.021218397,
0.009866623,
0.039273974,
-0.014218939,
0.00958472,
0.03688123,
0.0073982487,
0.013146331,
0.03410345,
0.027502783,
-0.023941172,
0.012108101,
0.001897692,
0.03792634,
-0.013675759,
-0.00785892,
-0.018935665,
-0.009247811,
-0.01463148,
0.023363614,
-0.00016415723,
0.027956579,
-0.0015822694,
0.025165046,
0.0021125574,
-0.0003611889,
-0.005222091,
0.02926296,
0.012479387,
-0.009832245,
0.009103421,
0.0062396936,
0.0031989175,
0.006418462,
0.00015276937,
-0.016859205,
-0.007913926,
-0.0075838924,
0.017271748,
-0.00096345687,
-0.012286868,
-0.008250834,
-0.0038882059,
-0.006686614,
0.0031765713,
0.021067131,
-0.006119369,
-0.0018822217,
0.00228445,
-0.021892214,
0.021314656,
0.01102174,
-0.003006398,
0.0008912621,
0.013407607,
0.030033039,
-0.004094477,
-0.016061625,
-0.0057790224,
0.0050123823,
-0.0049539385,
0.0023532067,
0.004812987,
-0.0059337253,
0.020420816,
-0.00055091514,
-0.004699538,
-0.0069753933,
-0.006126245,
0.013084449,
-0.009550341,
-0.016089128,
-0.008113321,
-0.013792645,
-0.01720299,
0.04119917,
0.015374055,
0.0016802482,
0.006775998,
-0.011509915,
-0.006284386,
-0.008904026,
0.019733246,
-0.010870475,
-0.036166158,
0.01967824,
0.013799521,
-0.0037438164,
-0.010602322,
-0.015869105,
-0.000875362,
0.0056586973,
-0.013043195,
0.027227756,
0.008525862,
-0.015085276,
-0.002710743,
-0.013813273,
-0.014975266,
-0.010650452,
0.07255234,
0.017546775,
0.012053095,
-0.018619385,
-0.00067811547,
-0.010237911,
-0.01453522,
0.010451057,
-0.014163933,
0.019141937,
-0.0316007,
0.0061124936,
-0.006305013,
-0.009350946,
0.025055036,
0.01289193,
-0.038696416,
0.021603435,
-0.009949132,
0.0032951771,
-0.008972783,
0.01359325,
0.0092684375,
-0.0075770165,
-0.021424668,
-0.025825113,
-0.0068722577,
-0.010107272,
-0.016735444,
0.0015083557,
-0.0062259426,
0.011317395,
0.013503866,
-0.0012685659,
-0.020475822,
-0.000570253,
-0.014590226,
-0.041969247,
0.010870475,
-0.0017653349,
0.018000571,
0.01701047,
0.02550883,
0.012788794,
-0.0069513284,
0.009811617,
0.029372972,
-0.0207646,
-0.027750308,
-0.026361417,
-0.014590226,
0.0024907207,
0.018110583,
0.04524208,
-0.040759124,
-0.009804742,
-0.008188954,
-0.006848193,
0.020640839,
-0.005039885,
0.010114148,
0.04183173,
-0.0061606234,
0.008188954,
-0.0065869163,
-0.17502771,
0.02400993,
0.0062981374,
0.004204488,
0.012334998,
-0.013916408,
-0.0064700297,
0.014108928,
-0.013221962,
-0.007274486,
0.0144939665,
0.005521184,
-0.038696416,
-0.008959032,
-0.00731574,
0.0027898136,
-0.014562723,
0.028327866,
0.03113315,
0.009804742,
0.016680438,
-0.022002226,
0.01630915,
0.0076113953,
0.015786598,
0.0027262133,
-0.016776698,
0.011482412,
0.00327455,
-0.014108928,
-0.0027795,
0.00998351,
-0.00039814576,
-0.014246441,
0.008271462,
-0.0034086262,
-0.039466493,
-0.018536875,
-0.005060512,
0.026650196,
0.02202973,
0.016144134,
0.02086086,
-0.002915295,
-0.014246441,
0.02857539,
0.011076746,
-0.0034756642,
0.035148557,
-0.010939232,
0.00020089923,
-0.016130382,
0.00004488003,
0.0058134007,
0.0029067004,
0.023693647,
-0.0017197834,
0.022070983,
0.031270664,
-0.01531905,
0.01017603,
-0.005105204,
0.018426865,
0.013105076,
-0.03352589,
-0.02768155,
0.00012494429,
-0.0042732446,
-0.012761291,
0.013455736,
0.0028534138,
-0.006782874,
0.014315198,
-0.026031384,
0.04400445,
-0.013765143,
-0.022758553,
0.05107267,
-0.02590762,
-0.011386152,
-0.031875726,
0.010004138,
-0.014060798,
-0.017092979,
0.020489573,
0.009124048,
0.0073569943,
0.015044022,
0.0033381502,
-0.0126512805,
0.008298964,
-0.041776728,
0.0029582682,
-0.019691993,
0.009323443,
0.021190895,
-0.026828965,
0.006913512,
-0.029510485,
-0.026416423,
0.017409261,
-0.018646887,
-0.036991242,
0.02164469,
0.024381217,
0.009962883,
-0.028685402,
-0.012479387,
0.017216742,
-0.0016699346,
-0.025151296,
-0.0057996493,
0.026842715,
0.010162278,
-0.0074257515,
0.04356441,
0.004070412,
0.0007326913,
0.012692534,
-0.029097944,
0.04889995,
0.0005973261,
0.001875346,
-0.007817666,
0.012259365,
0.0012900524,
-0.12794295,
-0.013421358,
-0.0064115864,
0.02125965,
-0.011998089,
0.012610026,
-0.010182905,
0.02707649,
-0.016776698,
0.048184875,
-0.011406779,
-0.030473083,
-0.0004576635,
-0.009990386,
0.0064665917,
-0.01295381,
-0.010691707,
-0.01729925,
-0.008285213,
0.0286579,
-0.007116345,
0.00880089,
0.015442813,
-0.02934547,
-0.00022861687,
-0.013923284,
-0.02627891,
0.0237074,
0.022703547,
0.028039087,
-0.0030820307,
-0.007212605,
-0.013008816,
0.0006673722,
-0.015676586,
-0.012830048,
-0.028960431,
-0.030500585,
0.017423013,
-0.022318508,
-0.015057773,
0.02351488,
0.0022655418,
0.0033536206,
-0.007157599,
-0.0013605283,
-0.0286579,
-0.0033175233,
0.02907044,
-0.033443384,
-0.011674931,
-0.027214004,
-0.019733246,
-0.0017043131,
-0.0131875845,
0.0013888906,
0.00044692022,
-0.016075376,
-0.013380104,
0.01097361,
0.002595575,
0.0040876013,
-0.024780007,
0.022222249,
0.035231065,
-0.008573992,
-0.0006286964,
-0.01670794,
0.004022282,
-0.010918605,
-0.019004423,
0.0024322774,
-0.033470888,
0.022882314,
-0.005923412,
0.016735444,
-0.0034911344,
0.0012840362,
0.0038950816,
0.00266777,
-0.012431257,
-0.016817952,
0.01817934,
-0.02736527,
0.021782205,
-0.008237083,
0.0010880788,
-0.022263503,
0.016350405,
-0.022579785,
0.028107844,
0.024188697,
0.03292083,
-0.013998916,
-0.008539614,
0.010966735,
-0.005407735,
-0.017574279,
0.013799521,
0.02984052,
-0.014672735,
0.00035839563,
-0.069967076,
0.02361114,
-0.0051189554,
-0.025811361,
-0.015209039,
0.007212605,
-0.015594078,
0.00819583,
0.0022947635,
0.015002768,
-0.032453284,
0.006415024,
-0.017161736,
0.004135731,
-0.015140282,
-0.0015796911,
0.02194722,
-0.013366353,
0.03941149,
0.0047717327,
-0.00864275,
-0.024477476,
0.0019011298,
-0.0025732291,
-0.016941715,
0.0068550687,
-0.009570968,
0.020530827,
-0.009213433,
-0.027516535,
0.027021484,
-0.0147552425,
-0.004699538,
0.010423555,
-0.008374597,
-0.0051842746,
0.014879005,
0.033745915,
0.03272831,
0.019251948,
-0.014837751,
-0.020228297,
0.017546775,
-0.011750564,
-0.03509355,
0.00880089,
-0.026058886,
0.021273402,
-0.0032006362,
0.003551297,
0.03124316,
-0.0007240967,
0.010375425,
-0.034048446,
-0.014081425,
-0.01541531,
0.007487633,
-0.007597644,
-0.038696416,
-0.022703547,
0.02797033,
0.054758042,
-0.002463218,
0.0271865,
0.0011310519,
-0.015209039,
-0.03833888,
-0.012176857,
-0.011228011,
-0.03231577,
-0.013655132,
-0.0005393124,
-0.013875154,
0.009832245,
0.011482412,
0.0016450102,
-0.0060471743,
0.0023377365,
-0.012568772,
0.020640839,
-0.00785892,
0.0015779722,
0.01225249,
0.021878464,
0.01867439,
-0.022703547,
-0.009570968,
0.032975838,
-0.006263759,
0.0021744387,
0.006641922,
0.021287154,
0.0130982,
0.0044210725,
0.005871844,
-0.005631195,
0.0108292205,
0.0046651596,
0.002377272,
-0.00009894556,
0.008333343,
-0.0004770014,
0.02224975,
-0.015497818,
-0.005689638,
-0.0032384526,
-0.03718376,
-0.037403785,
-0.02153468,
0.004754544,
0.0054317997,
0.008656501,
0.01551157,
0.0041047903,
-0.0227448,
0.007274486,
-0.013675759,
0.004978004,
-0.015484067,
0.015374055,
-0.0023342988,
0.008415852,
0.015937863,
0.01828935,
0.008381473,
-0.0118605755,
0.016652934,
-0.04587464,
0.024133692,
-0.0055314973,
0.0212459,
-0.022304757,
-0.046314687,
-0.015841603,
0.004063536,
-0.013469487,
0.003527232,
-0.0044657644,
0.0017876809,
0.08146324,
0.010107272,
-0.009096545,
0.008436479,
-0.044114463,
0.0147552425,
0.013111952,
-0.0016484481,
0.017313002,
-0.024738753,
-0.00293936,
-0.0049883174,
0.0041701095,
-0.022318508,
-0.031490687,
-0.005132707,
-0.0006811236,
0.012101225,
-0.038393885,
-0.028107844,
0.0256876,
-0.026553936,
0.012933183,
0.014397707,
0.0043282504,
-0.005899347,
0.0036716214,
0.013648256,
0.0024254017,
-0.03074811,
-0.006552538,
-0.005521184,
-0.017739294,
-0.027351517,
-0.0025422885,
-0.006260321,
0.010231035,
-0.031215658,
0.016680438,
0.008677128,
-0.009158427,
0.012355625,
0.0016785292,
-0.02046207,
-0.04359191,
-0.016075376,
-0.01052669,
-0.016075376,
-0.015979117
] |
To characterize the properties of adult neural stem cells (NSCs), we generated and analyzed Sox2-GFP transgenic mice. Sox2-GFP cells in the subgranular zone (SGZ) express markers specific for progenitors, but they represent two morphologically distinct populations that differ in proliferation levels. Lentivirus- and retrovirus-mediated fate-tracing studies showed that Sox2+ cells in the SGZ have potential to give rise to neurons and astrocytes, revealing their multipotency at the population as well as at a single-cell level. A subpopulation of Sox2+ cells gives rise to cells that retain Sox2 | [
-0.0006832308,
0.0024128812,
-0.0074866344,
-0.025911665,
-0.019343264,
0.0042124884,
-0.008217202,
0.01987946,
-0.0309385,
-0.00580432,
0.018659616,
0.007466527,
-0.008518811,
-0.0037466683,
-0.012091216,
0.010274853,
0.0199867,
0.001481241,
-0.0069370335,
0.016648881,
-0.022922372,
0.008666265,
-0.0033344678,
-0.027319178,
0.0012810053,
0.0224532,
-0.005479251,
-0.012969237,
-0.01087137,
-0.003800288,
0.003934337,
0.006313706,
-0.029035004,
-0.0063204085,
0.00075947115,
-0.0008294279,
-0.008719885,
-0.0029993455,
0.005321744,
0.0044068596,
0.00906171,
0.00085414323,
-0.020308418,
-0.004996675,
0.004741982,
-0.0030110748,
-0.03126022,
-0.00014064668,
0.00074941746,
0.019343264,
0.016903574,
0.010140804,
-0.011756094,
0.007030868,
-0.021836575,
-0.025884854,
0.0069504385,
-0.006290247,
-0.0033998168,
-0.02844519,
0.013981306,
0.0114008635,
-0.02004032,
0.029142244,
-0.0072051315,
0.009430344,
-0.018110014,
0.018766854,
0.018404922,
-0.020000104,
0.032976042,
0.0013882446,
-0.01481241,
-0.021085901,
0.011353947,
-0.011782903,
-0.02949077,
-0.009933027,
0.0015465899,
-0.004222542,
0.015522869,
-0.04225223,
-0.015321796,
0.01481241,
0.006477916,
0.020951852,
0.0015063751,
0.01672931,
-0.0026441158,
0.008324441,
0.03096531,
0.030268256,
0.021863386,
0.01864621,
0.0032674433,
-0.000475036,
-0.010361984,
0.027774945,
0.006327111,
-0.0125939,
-0.0138606625,
0.0064209453,
-0.008069747,
-0.0224532,
-0.0251878,
-0.0037332636,
0.035335306,
-0.002034193,
0.021260165,
0.013036261,
-0.00030642754,
0.018967928,
0.0038103417,
-0.036354076,
0.032064512,
0.0070978925,
0.03439696,
0.0136193745,
-0.012372719,
-0.005747349,
0.011353947,
0.011715879,
0.020884829,
-0.035683833,
0.0205363,
0.032761566,
-0.0025234716,
-0.0010439063,
-0.018525567,
0.0031065845,
0.016166305,
-0.00865286,
0.010516141,
0.025201205,
-0.0028267575,
-0.0023676397,
0.015576489,
0.01544244,
-0.023579212,
-0.04265438,
-0.0014753763,
0.029008195,
-0.018445136,
0.013022857,
0.002206781,
0.011032229,
0.02455777,
-0.0025284984,
0.022158293,
0.005341851,
0.0032774971,
-0.014008116,
0.03498678,
-0.015321796,
-0.009886111,
0.019383479,
0.02321728,
0.039410394,
-0.024785653,
0.014410263,
-0.00566692,
-0.007821756,
0.022828538,
-0.01125341,
-0.012714543,
0.02266768,
0.012231967,
0.012138133,
0.0043934546,
-0.029329913,
0.0012474931,
0.01680974,
-0.020241393,
0.017426364,
-0.009410237,
0.010315067,
-0.0023944494,
-0.010529546,
-0.02017437,
-0.024490746,
-0.005428983,
0.023445163,
0.005579788,
-0.014249404,
-0.021059092,
-0.006437701,
0.03946401,
-0.013545647,
0.0013103286,
-0.00804964,
-0.013290955,
0.0029457258,
-0.002072732,
-0.011447781,
-0.63914543,
-0.041608796,
0.013766828,
-0.013237335,
0.019061763,
0.043431863,
-0.008083153,
-0.013994711,
-0.027480036,
0.03107255,
-0.028069852,
0.0051642363,
0.015067103,
-0.0057205395,
-0.010301663,
-0.013344574,
-0.005428983,
-0.003756722,
0.030992119,
-0.005519466,
-0.023619426,
0.0023425056,
-0.002401152,
0.03193046,
0.0135657545,
0.034745492,
0.021380808,
-0.03375353,
-0.021032281,
0.03603236,
-0.030750832,
0.017935751,
-0.0028401623,
0.009852598,
0.041769657,
0.001623668,
-0.02589826,
0.022493415,
0.00018641184,
0.039169107,
-0.016997408,
-0.010469223,
0.0061662523,
-0.0048559234,
-0.023431757,
-0.000025107998,
-0.0003684252,
0.013652886,
0.0021280271,
-0.0028401623,
0.012459851,
0.0037969367,
-0.012794973,
0.0050033773,
0.01541563,
0.009919623,
0.0053485534,
-0.002724545,
0.015348606,
-0.0026189815,
-0.0017677706,
0.005878047,
-0.017654248,
-0.014584526,
0.0112936245,
0.019209215,
-0.008042937,
-0.008565729,
0.01607247,
-0.025925068,
-0.0020878126,
0.02565697,
-0.03361948,
0.023753475,
0.008793612,
0.036488127,
-0.0003956539,
-0.011260113,
-0.012017489,
-0.0033713314,
-0.007526849,
-0.017895536,
-0.0084853,
0.0017040974,
0.0038136928,
-0.015723944,
-0.01410195,
0.016353972,
-0.018110014,
0.018900903,
0.000656421,
0.008217202,
-0.00941694,
-0.053700015,
-0.009242676,
0.010958502,
-0.004339835,
0.030187825,
0.02337814,
-0.027533656,
-0.008371358,
-0.0060087447,
0.038391624,
0.0026273597,
0.011601937,
0.019048357,
-0.019919675,
-0.0038371515,
0.029169053,
-0.038257573,
0.005958476,
0.0034919754,
-0.004788899,
-0.018458541,
-0.015254771,
-0.020080535,
0.014852624,
0.0070241652,
-0.013290955,
-0.024034979,
0.010073779,
-0.00470847,
-0.0042895665,
0.025295038,
0.024008168,
-0.006705799,
-0.0023843958,
0.012466554,
-0.0052346117,
-0.02006713,
-0.005040241,
-0.025362063,
0.01754701,
-0.036917083,
0.012634114,
-0.011682367,
0.013177013,
0.003917581,
0.00063757034,
-0.023525592,
-0.041662417,
0.0048559234,
-0.0037500197,
-0.026032308,
-0.00963812,
0.012828485,
-0.008123367,
-0.017345935,
0.007949104,
-0.00009865165,
-0.009068412,
-0.01601885,
-0.01062338,
0.013096583,
0.01982584,
-0.0045442595,
-0.014249404,
-0.010509439,
0.015951825,
-0.018981332,
-0.015134128,
0.027453227,
0.0036796439,
0.0008382249,
-0.019732006,
-0.016434403,
-0.026072523,
0.021957219,
0.0036964,
-0.029758869,
-0.017453175,
-0.006075769,
-0.01125341,
0.02179636,
0.01317031,
-0.00012514727,
-0.006099228,
0.00015143343,
-0.002488284,
-0.016394189,
-0.00015551774,
-0.01883388,
-0.010060375,
-0.008156879,
0.029973347,
0.015214557,
0.024034979,
0.012828485,
-0.00083277916,
0.0073257755,
-0.0023207227,
0.025335254,
-0.00859924,
0.006712502,
0.00607912,
-0.024624795,
0.006042257,
-0.0023776933,
-0.0022754811,
0.011742689,
0.011005419,
-0.0033478728,
0.00083110353,
-0.021474643,
0.02376688,
-0.033968005,
-0.00056342455,
-0.03182322,
-0.007198429,
0.013177013,
0.020871423,
0.012044299,
-0.016032256,
-0.017024217,
-0.0036964,
0.0029440504,
0.009691739,
-0.008786909,
0.008284226,
-0.01935667,
-0.003904176,
-0.0014829166,
-0.0046012304,
-0.007272156,
0.0017711219,
0.03091169,
-0.007406205,
0.010482629,
0.014544312,
-0.013445111,
0.0020408954,
0.029115435,
0.011762796,
0.02174274,
0.018525567,
0.009933027,
0.019383479,
-0.016434403,
0.023619426,
-0.00049765676,
-0.01128022,
0.0095576905,
-0.004383401,
0.0054189293,
-0.008820421,
-0.020295013,
0.03831119,
-0.00011697866,
-0.016581856,
0.012359314,
-0.022064459,
-0.007955805,
-0.013063071,
0.0026960596,
0.014678361,
0.0060187983,
0.003951093,
0.014691766,
0.01065019,
0.031045739,
0.005579788,
-0.01130703,
-0.021005472,
-0.020053724,
-0.012768163,
0.014906244,
0.0172521,
-0.014437073,
-0.0051977485,
-0.0016102631,
-0.01738615,
0.016957194,
0.006209818,
-0.017573819,
0.0010807697,
-0.0051843436,
0.004142113,
-0.0014745386,
0.017681058,
-0.0015097264,
-0.016514832,
-0.021997435,
0.00963812,
0.024383506,
-0.008538919,
-0.0052547194,
-0.013639482,
-0.028552428,
-0.01226548,
-0.009222568,
0.0014435397,
0.0013279225,
-0.0035858096,
-0.0037165075,
-0.01946391,
-0.010167614,
-0.00018484094,
-0.008364655,
0.012801676,
-0.007171619,
0.0058143735,
-0.011622045,
-0.010770834,
-0.00580432,
0.027439822,
0.0032791726,
-0.00610593,
-0.010174316,
-0.0091019245,
-0.008827124,
0.00028862417,
-0.031608745,
-0.0037768295,
0.018284278,
-0.0023760179,
-0.0090349,
0.0056803245,
-0.0024229349,
0.031689174,
0.011407566,
-0.018860688,
-0.037801806,
-0.009510773,
-0.02581783,
0.01867302,
0.03361948,
0.003356251,
-0.0018381464,
0.011494698,
-0.012520173,
-0.010697107,
0.0061427937,
0.021139521,
-0.028874146,
-0.007573766,
0.004594528,
-0.014343238,
-0.012030894,
0.010160911,
0.02510737,
0.0009509098,
-0.017841917,
0.00043649692,
-0.009370022,
0.0069035213,
0.014973269,
0.01130703,
0.042761616,
0.0047319285,
0.0026977353,
0.009644822,
0.017614033,
-0.019182406,
-0.011997382,
-0.0109518,
0.009537583,
-0.010677,
-0.00051064277,
-0.00005228433,
-0.026139546,
0.0055998955,
0.021059092,
-0.0007975913,
0.015790967,
0.022198508,
0.018431732,
0.01869983,
-0.010361984,
-0.00465485,
0.00034014924,
0.00898128,
0.0073592877,
-0.017681058,
-0.015898207,
0.021233356,
-0.030402305,
0.003592512,
-0.004624689,
0.0064343503,
-0.013089881,
-0.001174604,
-0.012721246,
-0.008230606,
-0.020268202,
-0.013740018,
-0.023418354,
0.016796334,
-0.014959864,
-0.014517502,
-0.031769603,
0.02061673,
-0.0015097264,
-0.025040345,
-0.0089410655,
0.040536404,
0.0019504124,
-0.056032464,
0.0065114284,
0.02174274,
0.03490635,
0.019678388,
-0.015656918,
-0.009162246,
0.013686399,
0.009859301,
-0.03337819,
-0.0037533708,
-0.007942401,
0.01749339,
0.0057808612,
-0.008894148,
-0.015589894,
-0.007546956,
-0.009276188,
0.031394266,
-0.017064432,
-0.00007566436,
0.0027161671,
-0.008605943,
0.01927624,
0.032976042,
0.009524179,
-0.004912894,
0.0014251079,
-0.0076072784,
-0.025120774,
-0.017131457,
-0.02365964,
-0.027748134,
-0.007077785,
-0.00033135226,
-0.00061159837,
-0.030455923,
-0.01864621,
0.012339206,
-0.016434403,
0.03107255,
-0.0014393507,
0.007942401,
0.010723917,
0.009095222,
0.0347723,
0.021608692,
-0.018324492,
0.014262809,
-0.012406231,
0.029061815,
0.0044236155,
-0.012352612,
0.0035087315,
0.014329834,
-0.0089678755,
-0.019852651,
0.0009928001,
0.0036695902,
0.03852567,
-0.021715932,
-0.022332557,
-0.010690404,
-0.009490666,
-0.008666265,
0.015053698,
0.024919702,
-0.012714543,
-0.0051206704,
0.012399529,
-0.009812384,
-0.021313785,
0.019383479,
-0.038203955,
0.0009056683,
0.016367378,
0.02319047,
-0.007835162,
-0.015898207,
0.020375442,
-0.0020107343,
-0.017091243,
-0.0006765283,
-0.022748109,
0.010248043,
-0.02839157,
0.029839298,
0.021836575,
0.03973211,
0.013914282,
0.0064578084,
0.018177038,
0.0008097395,
0.015187747,
-0.015281581,
0.02332452,
-0.017895536,
0.0372388,
-0.011146171,
0.011615342,
0.015348606,
-0.01738615,
0.018740045,
0.03324414,
-0.0043666447,
-0.0052915826,
0.020295013,
-0.05034879,
-0.034075245,
0.00867967,
-0.014624742,
0.011179683,
-0.027091295,
0.0015708862,
0.026568504,
-0.0026424401,
-0.015067103,
0.010127399,
0.025750805,
0.00074564735,
0.0073391804,
0.012258777,
0.0016446132,
-0.00900809,
0.0022855347,
-0.0005173452,
-0.006702448,
0.0052547194,
-0.0062433304,
0.012312397,
0.014731981,
-0.005130724,
0.017238697,
0.020522896,
-0.036488127,
-0.0034919754,
0.0025385523,
-0.03983935,
-0.0063003013,
-0.016903574,
-0.019866055,
-0.019383479,
-0.0051240213,
0.002168242,
-0.020482682,
0.016501427,
-0.009443749,
-0.016662285,
0.03624684,
-0.0138338525,
0.023686452,
-0.009517476,
0.011709177,
0.022439796,
0.0051005627,
-0.028150281,
-0.014530907,
-0.008800314,
0.008820421,
0.026890222,
0.026984055,
-0.018002775,
-0.021313785,
0.012935724,
0.012848592,
-0.015281581,
-0.017037623,
0.018565781,
0.0073592877,
0.0058914516,
-0.0027094646,
-0.007996021,
-0.031581935,
0.01812342,
-0.008344548,
-0.0043632938,
0.0050636996,
-0.004621338,
-0.022332557,
0.030187825,
0.0008005236,
0.007546956,
0.014718575,
0.01591161,
-0.014061736,
-0.015013483,
0.0037198586,
0.008398167,
-0.021729337,
0.0410726,
-0.025335254,
0.007962508,
0.019919675,
0.011286923,
-0.02589826,
0.0013840555,
0.011166278,
0.040724073,
-0.009430344,
-0.015455845,
0.01352554,
-0.0071112975,
0.00996654,
0.0016906925,
-0.0070978925,
-0.013518837,
-0.02828433,
-0.0068465504,
0.046005603,
0.015348606,
0.009329808,
0.0066789896,
-0.025831234,
-0.009550989,
-0.03879377,
-0.03600555,
-0.003709805,
-0.027185129,
-0.0018063097,
0.00966493,
0.029329913,
0.018686425,
-0.0052748267,
-0.004101898,
0.0040214686,
0.02017437,
-0.019745411,
0.023150256,
0.012298992,
0.02461139,
-0.031957272,
0.00807645,
0.00470847,
-0.03718518,
-0.003954444,
-0.039437205,
-0.017707868,
-0.023069825,
-0.0015398874,
0.020295013,
0.0025083912,
-0.005774159,
0.009242676,
0.0071112975,
0.009644822,
-0.0114544835,
-0.00867967,
0.0025318498,
-0.017185077,
-0.01544244,
-0.003455112,
-0.023016207,
-0.0049732164,
-0.003843854,
-0.0072319414,
0.02061673,
-0.020522896,
-0.0062031155,
-0.0064276475,
-0.009798979,
0.0011059039,
0.0016689096,
-0.015026888,
-0.01128022,
-0.01251347,
-0.007808352,
0.004453777,
-0.0065114284,
-0.040375546,
0.013605969,
0.0052547194,
0.01483922,
-0.019021546,
-0.0078016496,
-0.0038706637,
-0.038364813,
-0.045254927,
0.007479932,
-0.038981438,
0.037614137,
0.008344548,
-0.0135925645,
-0.013780233,
-0.0061863596,
-0.047077995,
-0.013304359,
0.009430344,
0.02203765,
-0.0007661736,
0.03238623,
-0.024638198,
-0.035603404,
-0.0024279617,
0.021568477,
-0.016434403,
-0.023632832,
0.028874146,
0.006712502,
0.02447734,
0.0045241523,
-0.013384788,
-0.020710563,
0.04128708,
-0.003967849,
-0.0033880875,
0.018740045,
-0.026354026,
0.045817934,
-0.012004084,
0.03871334,
0.03353905,
0.010006755,
0.017077837,
-0.03096531,
-0.00066479907,
-0.003652834,
-0.0026441158,
-0.001317031,
-0.0010179343,
-0.007178322,
-0.009604608,
-0.0024732032,
-0.012298992,
-0.008337845,
0.014906244,
0.02453096,
0.027560467,
0.01683655,
0.017372746,
0.02571059,
0.018753449,
0.003994659,
0.0008042938,
0.004145464,
0.0015608326,
0.001092499,
-0.004688362,
0.0056200027,
0.0006832308,
-0.005134075,
0.0030697212,
-0.02962482,
0.00862605,
0.0113472445,
-0.016367378,
-0.037882235,
0.026152952,
-0.009088519,
-0.028954575,
-0.008398167,
0.007540254,
0.0062165204,
-0.024933107,
0.0008017803,
-0.011890142,
-0.0027195183,
0.00007388402,
0.0076072784,
0.009979945,
-0.012372719,
-0.025482707,
-0.0016077497,
-0.0034919754,
0.0140483305,
0.1861672,
-0.00089980365,
0.0031819872,
0.007835162,
-0.0061394423,
-0.010911585,
0.017788297,
0.010254745,
0.015938422,
0.011950465,
-0.00164964,
0.023110041,
0.0019185757,
-0.007815055,
0.02823071,
-0.024678413,
0.0008838853,
-0.025549732,
-0.016407592,
-0.024732033,
0.0022302396,
-0.011508103,
0.020362036,
-0.0011251734,
0.01730572,
0.012412934,
-0.028874146,
0.008552324,
0.012446445,
0.014691766,
-0.007647493,
0.014919649,
-0.0034484095,
0.0067393114,
0.022828538,
-0.005864642,
0.010529546,
-0.0011260113,
0.007701113,
-0.010723917,
0.009597906,
-0.0016722608,
-0.004745333,
0.03490635,
0.0059182616,
0.027828565,
-0.0016002095,
0.022091268,
-0.0032289042,
0.0047687916,
-0.036702607,
0.008217202,
-0.0028518916,
0.020000104,
0.008445084,
-0.0024514203,
0.018941117,
0.00022432256,
-0.0072788587,
0.041930515,
-0.02658191,
0.010817751,
-0.026890222,
0.030429114,
0.0055395733,
0.015938422,
-0.000695379,
-0.004926299,
0.02447734,
-0.007781542,
0.014034926,
0.005204451,
-0.027439822,
-0.008257416,
-0.0027731378,
-0.005579788,
0.0295712,
0.0060389056,
0.010817751,
0.010274853,
0.018337898,
0.017037623,
-0.028874146,
0.015992042,
0.0018967928,
-0.03479911,
0.016769525,
0.0022503468,
-0.019866055,
-0.025040345,
0.0113204345,
-0.015308391,
-0.0007146485,
-0.021608692,
-0.009959837,
-0.017654248,
-0.016313758,
0.017949156,
-0.005134075,
-0.010978609,
-0.041957323,
0.057480194,
0.0147856,
0.016769525,
0.0075000394,
-0.0008256578,
0.00062039535,
0.0021397565,
-0.026045714,
0.007305668,
-0.007004058,
-0.013652886,
0.0092895925,
-0.011447781,
-0.002543579,
0.017185077,
-0.0052413144,
-0.03356586,
0.059785835,
-0.019799031,
0.00006110747,
-0.010576463,
0.0017979316,
0.025911665,
-0.018605996,
-0.00993973,
-0.010529546,
0.0017049352,
-0.0076072784,
-0.028847337,
-0.003666239,
-0.021286976,
0.0054122265,
0.0029658333,
0.01410195,
-0.018766854,
0.0077480297,
0.013766828,
-0.027962612,
0.010087185,
-0.0075000394,
-0.011896845,
0.006642126,
-0.003342846,
0.010227935,
-0.012587197,
0.02442372,
0.033887576,
-0.0017677706,
-0.014933054,
0.0062801936,
-0.018900903,
0.017345935,
0.0044236155,
0.005519466,
-0.03758733,
-0.017975966,
-0.0408045,
0.0009835842,
0.01223867,
-0.027225344,
0.034557823,
-0.015831182,
-0.017882131,
-0.013431706,
-0.012439744,
-0.16943789,
0.0006727582,
0.02959801,
-0.009819087,
0.019973295,
0.021340594,
0.011970572,
-0.012808378,
0.0072252387,
0.03737285,
0.036943894,
-0.009115329,
-0.044665113,
-0.007908888,
-0.00008357115,
0.021756146,
0.007949104,
0.04348548,
0.015750753,
0.02636743,
0.035630215,
-0.002159864,
0.017118052,
0.0003631889,
0.016876765,
0.00006990444,
0.008666265,
0.0030093992,
-0.012526875,
-0.036622174,
-0.001900144,
-0.0034819217,
0.02182317,
-0.009168949,
-0.0005965179,
0.0030579919,
-0.0048391675,
-0.009403534,
0.0042325957,
0.021648906,
0.008827124,
0.023552403,
-0.0056468123,
-0.0029440504,
0.0056065978,
0.023069825,
-0.006233277,
-0.009926326,
0.006883414,
0.00076407904,
0.022412986,
-0.0133512765,
0.007868674,
0.023538997,
0.027506847,
0.0032188506,
0.0089678755,
0.010549653,
0.020656945,
0.007292263,
0.0019034952,
-0.016796334,
0.022640869,
0.0009919623,
0.0009676659,
-0.043244194,
0.0061427937,
0.00003458568,
-0.030348685,
-0.010811049,
-0.019571148,
0.0043297815,
0.022935776,
-0.019678388,
0.033190522,
0.018244063,
0.005556329,
0.009671632,
-0.0014988349,
0.010442414,
-0.011729284,
0.031662364,
-0.02064354,
-0.008190392,
-0.013103286,
0.010482629,
0.02184998,
0.008270821,
-0.006923629,
0.0036829952,
0.00933651,
-0.007466527,
0.003515434,
0.001343003,
0.030241445,
0.00845849,
-0.0071179997,
0.000112894355,
-0.0028636209,
-0.0020543004,
0.0271047,
-0.0034685167,
-0.022024244,
-0.008592539,
0.0410726,
-0.00250504,
-0.030536354,
0.027480036,
0.034102056,
-0.0044169133,
0.005492656,
-0.014088546,
0.010442414,
0.0042527034,
-0.006196413,
0.03337819,
-0.0050301873,
-0.000231025,
0.027238749,
-0.034933157,
0.06053651,
-0.009430344,
0.0036260244,
0.031179788,
0.00092493783,
-0.01982584,
-0.12664945,
-0.032815184,
-0.0056300564,
0.029142244,
-0.026756173,
0.006400838,
0.0034986779,
0.023337923,
-0.024262862,
0.025603352,
-0.014611336,
-0.021622097,
0.00009891347,
-0.012010787,
0.015214557,
-0.009168949,
0.017815107,
0.003187014,
-0.027372798,
0.022748109,
-0.0007854431,
0.007124702,
-0.012587197,
-0.0070978925,
-0.0047788452,
0.034933157,
-0.03957125,
0.024115408,
0.028364759,
0.030000158,
0.014142165,
-0.033136904,
0.031501506,
0.003890771,
-0.01541563,
-0.009162246,
-0.00048508967,
-0.055174552,
0.030750832,
-0.013820448,
-0.0006731771,
0.014343238,
0.019705197,
-0.0055730855,
-0.017185077,
0.004969865,
-0.006451106,
-0.0054256315,
0.012781568,
-0.029008195,
-0.03466506,
-0.01251347,
-0.013371384,
-0.008465191,
0.027171724,
-0.0076541957,
0.020362036,
0.009122032,
-0.018311087,
-0.008800314,
0.017225292,
0.0056870272,
-0.00210792,
-0.01538882,
0.008465191,
0.006923629,
-0.044531066,
-0.032707945,
0.015080508,
-0.038874198,
-0.004798953,
0.018150229,
-0.004963163,
-0.0062031155,
-0.017010814,
0.0011846577,
-0.0008964524,
-0.0035120826,
0.00006393507,
-0.022211913,
-0.014142165,
-0.024799058,
0.022841943,
-0.011970572,
0.021715932,
0.009564393,
0.018471947,
-0.018311087,
0.015429035,
-0.015563084,
0.009068412,
0.03973211,
-0.009483964,
-0.033699907,
-0.021474643,
0.0067393114,
-0.008230606,
0.0025083912,
0.028793717,
0.014825815,
-0.014705171,
-0.040375546,
-0.054665167,
0.012037597,
-0.002236942,
-0.009845896,
-0.007922294,
-0.01995989,
-0.012533578,
-0.020335227,
-0.0093164025,
-0.010837859,
-0.008250713,
0.0019487367,
-0.022372771,
0.010985312,
-0.031876843,
-0.02179636,
0.030509543,
-0.003713156,
0.0052714753,
0.015160937,
0.013277549,
-0.0136729935,
-0.008639456,
-0.002228564,
-0.030643592,
0.0033629532,
-0.018163634,
0.024437126,
-0.012272182,
-0.010529546,
0.013465218,
-0.036622174,
-0.008746695,
0.014410263,
-0.01168907,
-0.031394266,
0.025589947,
0.02050949,
0.019571148,
0.03715837,
-0.0232709,
-0.036917083,
0.021380808,
0.007915591,
-0.008525514,
0.0012215212,
-0.02967844,
-0.004068386,
0.007272156,
-0.008813719,
0.030107396,
0.0057674563,
0.0137266135,
-0.029758869,
-0.0137534235,
-0.020429062,
-0.008632753,
0.0069370335,
-0.011555021,
0.0013781908,
0.016193114,
0.023485377,
0.027359392,
0.009671632,
-0.016434403,
-0.026782982,
-0.02379369,
0.02124676,
-0.00813007,
-0.022493415,
-0.026327215,
0.0074732294,
0.034745492,
0.014638146,
0.0043934546,
-0.015254771,
-0.013009451,
-0.024799058,
-0.024195837,
0.01355235,
0.01317031,
-0.0072185365,
0.0042728106,
0.026300406,
0.02954439,
0.002319047,
-0.019209215,
0.035549782,
0.001766095,
0.00028045557,
-0.005881398,
0.009490666,
0.01609928,
-0.010663595,
0.008424977,
0.027292369,
-0.022077864,
0.028471999,
0.0018666318,
0.011126064,
-0.022144888,
0.01853897,
0.02565697,
-0.022278937,
-0.0078016496,
0.01410195,
-0.03731923,
-0.019101977,
-0.00076030893,
-0.014316428,
-0.009088519,
-0.0000758738,
-0.007794947,
-0.00084492733,
-0.022412986,
-0.003847205,
-0.00026788848,
-0.015589894,
-0.00035271634,
0.012084514,
0.017614033,
-0.0004607933,
0.0115885325,
0.0071045947,
-0.00013164026,
-0.009537583,
0.028793717,
-0.032976042,
0.01319712,
-0.02006713,
0.032922424,
0.0049162456,
-0.016541641,
-0.008371358,
-0.015750753,
-0.024021573,
-0.0012114674,
0.039329965,
-0.011601937,
0.09313722,
0.016581856,
-0.017319126,
-0.020415656,
-0.01930305,
0.014584526,
-0.003502029,
0.015522869,
-0.019678388,
-0.040643644,
0.038338,
-0.047212042,
0.02644786,
-0.016823145,
-0.015549679,
0.006642126,
-0.01612609,
0.009859301,
-0.008786909,
-0.008264119,
0.02302961,
-0.02644786,
0.016568452,
0.028069852,
-0.0232709,
-0.009115329,
0.018874094,
-0.024236051,
-0.0066454774,
-0.0066488283,
0.005703783,
-0.010113994,
-0.04898149,
-0.0048090066,
-0.01070381,
0.0049330015,
0.002184998,
-0.045657076,
0.00013425841,
0.03479911,
-0.0038673126,
-0.005492656,
0.007915591,
-0.0014066763,
0.019128786,
-0.016608667,
-0.024705224,
-0.014235999,
-0.009443749
] |
OBJECTIVE To examine whether past high sun exposure is associated with a reduced risk of multiple sclerosis. DESIGN Population based case-control study. SETTING Tasmania, latitudes 41-3 degrees S. PARTICIPANTS 136 cases with multiple sclerosis and 272 controls randomly drawn from the community and matched on sex and year of birth. MAIN OUTCOME MEASURE Multiple sclerosis defined by both clinical and magnetic resonance imaging criteria. RESULTS Higher sun exposure when aged 6-15 years (average 2-3 hours or more a day in summer during weekends and holidays) was associated with a decreased risk of multiple sclerosis (adjusted odds ratio 0 | [
0.0023622517,
0.005067438,
0.016034678,
-0.044454947,
-0.05625455,
0.041365206,
0.0013592519,
-0.004368251,
-0.0011395076,
-0.008123882,
-0.013051482,
0.017486323,
0.007877502,
0.0041118828,
-0.015382104,
0.003439332,
0.043842327,
-0.008157176,
0.009522255,
0.0071649975,
-0.024997583,
0.014409902,
-0.0062227603,
-0.00009202835,
0.0073248115,
-0.009515596,
0.0028999595,
-0.032761883,
-0.00058723346,
-0.015808275,
0.034599744,
-0.024824452,
-0.011020511,
0.00055976544,
-0.024424916,
0.0049509066,
0.005773283,
0.010527751,
0.00023826446,
-0.010501116,
-0.0008436019,
0.0021391779,
-0.0073048347,
-0.008263719,
0.026941989,
0.0032345701,
0.017552912,
-0.017140059,
-0.0100216735,
0.030710936,
0.02569011,
0.027514655,
-0.019590542,
0.006931935,
-0.011999372,
-0.029805323,
0.009835224,
0.002796746,
-0.010967241,
-0.01817885,
0.019737037,
0.012865032,
-0.040832493,
0.0053837365,
-0.0131114125,
-0.008090587,
-0.019430727,
0.011846217,
-0.0023505986,
-0.009928449,
0.041818015,
0.035585266,
0.012498791,
-0.019337501,
0.014876026,
0.0011253573,
-0.00954889,
0.0021641487,
0.015262243,
0.008376921,
0.013564219,
-0.0054936083,
-0.02310645,
0.024664637,
-0.0006966895,
0.0073248115,
-0.0009963408,
0.012838396,
0.0029515661,
0.00030006756,
-0.013417723,
0.0027351512,
0.02674222,
-0.0035025915,
-0.0018078967,
0.009069448,
0.014489809,
0.03310815,
-0.025863243,
0.007098408,
-0.013970413,
-0.014396584,
-0.020909008,
-0.008410215,
-0.037822664,
0.011460001,
-0.005473632,
-0.002680215,
0.0055035967,
-0.019244278,
-0.017020198,
0.04485448,
0.0021241952,
-0.02514408,
-0.013943777,
0.013903824,
0.0076178038,
0.00018977921,
-0.0036757234,
0.0015540253,
0.027408112,
0.011879512,
0.0025187363,
-0.017819269,
0.026768856,
0.00003927722,
-0.03734322,
-0.008030657,
-0.00031213684,
-0.0036657352,
-0.03310815,
0.0038655028,
0.012745172,
0.0038655028,
-0.014037002,
0.0136041725,
-0.02038961,
-0.023306219,
-0.03800911,
-0.026489181,
-0.007338129,
0.012958257,
0.005120709,
-0.0023222982,
0.02038961,
0.032468893,
0.013071459,
0.0024055347,
-0.011100419,
-0.016753841,
0.0134376995,
-0.029485695,
0.0021641487,
0.012931622,
0.023053179,
0.022014387,
-0.002656909,
0.020416247,
-0.04541383,
-0.023905521,
0.012026008,
-0.00486767,
-0.001580661,
0.004534724,
-0.0001827041,
0.022600373,
-0.0061961245,
-0.022453876,
0.014476491,
0.0034360024,
-0.033987124,
0.03611798,
-0.019923488,
0.021241954,
0.023825614,
0.028313726,
-0.02096228,
0.024984267,
-0.00874982,
-0.035052553,
-0.024731226,
0.019896852,
0.04077922,
-0.00020101613,
-0.009975062,
0.015275561,
0.018631656,
0.013810599,
0.019617178,
-0.0068253926,
-0.0065157525,
-0.00032399804,
-0.01121362,
-0.018138897,
-0.64692736,
-0.023838932,
-0.033241324,
0.012638629,
0.003382731,
0.028260455,
0.018898014,
0.022320697,
-0.021867892,
0.025969787,
-0.0038655028,
0.027647834,
0.0012693565,
-0.0072382456,
-0.015448693,
-0.019124417,
-0.0066589196,
-0.001792914,
0.04043296,
-0.009935108,
-0.02951233,
0.012212458,
-0.0007120882,
0.020123255,
0.0085500525,
0.020815782,
0.001229403,
-0.04805076,
0.007990703,
0.020016711,
-0.023199676,
0.0074713076,
0.019523952,
0.024211831,
0.046452623,
-0.03358759,
-0.00249543,
0.026848763,
-0.0000056964973,
0.035585266,
-0.035212368,
-0.004721174,
0.029006254,
-0.011999372,
-0.008922952,
0.024384962,
0.0029066184,
-0.018684927,
0.015848229,
-0.015195654,
0.04349606,
0.012911645,
-0.007264881,
-0.026395956,
0.016340988,
-0.022693597,
0.011606497,
-0.024291739,
-0.0039720456,
0.010427868,
-0.014982569,
0.017832587,
-0.015501965,
0.0028083993,
-0.0131114125,
0.0051972866,
-0.023732388,
0.01811226,
0.017646136,
-0.019257596,
-0.004824387,
0.03574508,
-0.021588217,
0.01725992,
0.033933852,
-0.007005183,
0.018738199,
-0.0005239737,
-0.029725416,
0.010780791,
0.0150757935,
0.002020982,
-0.0159015,
-0.00573333,
0.011513271,
-0.023492668,
-0.019723719,
0.019444045,
-0.014676258,
0.0046812203,
0.026395956,
-0.0014999215,
-0.000017986886,
-0.030391308,
-0.008083928,
0.012805102,
-0.010634295,
-0.0003959976,
-0.007105067,
-0.013590855,
-0.009069448,
-0.008217107,
0.01749964,
-0.0021358484,
0.03241562,
0.00998172,
-0.020922326,
-0.0018511796,
0.021002231,
-0.028580083,
0.01004165,
0.021401767,
-0.011566543,
0.0069852066,
0.018351981,
-0.029059524,
0.004041964,
-0.013044823,
-0.009568867,
-0.014836073,
0.023985427,
0.0059697214,
0.010288031,
-0.011133714,
0.017672772,
0.03310815,
-0.012412226,
-0.012651947,
0.03249553,
-0.022813458,
-0.0021208657,
0.017153377,
0.028420268,
-0.01960386,
0.016966926,
-0.0044148634,
0.009815247,
-0.01121362,
0.020749193,
-0.024784498,
-0.029805323,
-0.004554701,
0.00021266924,
-0.019204324,
0.0007611977,
-0.03265534,
-0.009096084,
-0.004597984,
-0.0037789368,
-0.008829727,
0.00062094425,
-0.013783963,
0.0059630624,
-0.0023838931,
-0.025916515,
0.0031480042,
-0.0025720077,
-0.029432423,
0.0008128043,
-0.0010845715,
0.009555549,
0.03340114,
-0.025956469,
0.002963219,
-0.015328833,
-0.023905521,
-0.010467822,
0.033827312,
-0.01337111,
-0.020256434,
0.012645288,
-0.0061361943,
0.004454817,
0.00893627,
-0.025370482,
0.01016817,
-0.0029449072,
-0.013451017,
0.0031013917,
-0.011593179,
0.00795075,
0.0042483904,
0.0074113775,
-0.0073114936,
0.024944313,
0.00683871,
0.015342151,
-0.011113737,
-0.010714201,
0.020948961,
0.019404091,
0.029805323,
-0.00801068,
0.01996344,
-0.0011128719,
0.0045580305,
0.0022224144,
-0.0031197038,
0.026489181,
-0.0029315893,
0.0032745237,
-0.027541291,
0.025703428,
-0.005973051,
0.0314301,
-0.03148337,
0.012405567,
-0.026822127,
0.007684393,
0.01349763,
0.006026322,
-0.015382104,
-0.0053371238,
-0.0054236897,
-0.007364765,
0.011739675,
-0.010341302,
0.006299338,
-0.01386387,
-0.004571348,
-0.006958571,
0.026755538,
0.00807061,
-0.019803626,
0.0010304678,
0.014929297,
0.022746868,
-0.008596665,
-0.0026053023,
-0.0056434344,
0.0013758992,
-0.02137513,
-0.004917612,
0.016833749,
0.020442883,
0.011340139,
-0.018511796,
-0.025197351,
0.023878885,
0.026182871,
0.015115747,
0.022174202,
-0.0045147473,
-0.012252412,
-0.005506926,
-0.041018944,
0.010248077,
-0.009449007,
0.0055901627,
0.013397746,
-0.0067821094,
0.004055282,
-0.010747496,
-0.0022340675,
0.008942929,
0.006192795,
-0.00973534,
0.009888495,
0.012259071,
0.028260455,
0.037130136,
0.02323963,
0.004874329,
0.00912272,
-0.015635142,
-0.01904451,
-0.012345636,
-0.009322487,
0.0022140907,
-0.018698245,
-0.017726043,
-0.016620662,
0.013610831,
-0.04709188,
-0.00029340864,
0.011053806,
0.000088386754,
0.034919374,
0.011147032,
0.007684393,
-0.04330961,
-0.013397746,
0.015741685,
0.0063892333,
-0.008017339,
-0.004874329,
0.006582342,
-0.003679053,
-0.0016955273,
-0.016607344,
0.0063625975,
0.0064158686,
-0.045227382,
-0.010913969,
-0.00028342026,
-0.0055302326,
0.031989448,
-0.013024846,
0.0050141662,
-0.014689576,
-0.0076244627,
-0.024345009,
0.01170638,
-0.015368786,
0.020988913,
0.018098943,
-0.009835224,
-0.0015165689,
-0.01663398,
0.0010854038,
0.0029798665,
-0.010707542,
-0.011373434,
0.0204562,
0.012678582,
0.008849704,
0.01331118,
-0.022001069,
0.03340114,
-0.0054503256,
-0.020576062,
-0.04306989,
-0.01219914,
-0.013590855,
0.044534855,
0.019191006,
-0.0051906276,
0.026728902,
0.051300317,
-0.006439175,
-0.0036390994,
-0.04677225,
0.02052279,
0.029299246,
0.0045247357,
0.008596665,
-0.0054236897,
0.013291203,
-0.0010154853,
0.012725195,
0.021907846,
-0.0060496284,
-0.0034826149,
0.01688702,
-0.009355782,
0.004331627,
0.008456828,
0.057852693,
0.041498385,
-0.021548264,
-0.003209599,
0.028180547,
0.014103591,
-0.015914818,
0.008596665,
0.009741999,
0.01140007,
0.025370482,
0.014649623,
-0.008590006,
-0.0007695214,
-0.0041618245,
0.009156014,
-0.0030031726,
0.04195119,
-0.0041018943,
0.0063492795,
0.0022623679,
0.0032129285,
-0.025849925,
0.0016380942,
0.033907216,
-0.008942929,
-0.009322487,
0.010427868,
-0.003715677,
0.015515282,
-0.022147566,
-0.01472953,
-0.002328957,
-0.0030664324,
-0.010587682,
-0.024558095,
0.00073914,
-0.014596351,
-0.009901813,
0.017339826,
-0.0015257249,
-0.010148193,
-0.01947068,
-0.007524579,
-0.0064491634,
-0.032735247,
-0.001660568,
0.0074646487,
-0.0035958164,
-0.037742756,
0.0061095585,
0.020043347,
0.009915131,
0.01109376,
-0.011453342,
0.019137735,
0.005646764,
-0.0110071935,
0.0042550494,
0.014609669,
-0.013810599,
0.009662092,
0.03321469,
0.020549426,
-0.020043347,
-0.030311402,
0.020256434,
-0.006648931,
-0.0031080507,
0.006299338,
-0.014982569,
-0.0067621325,
-0.0027418102,
0.0073314705,
0.036570784,
-0.02089569,
-0.014276723,
-0.011473319,
-0.044641394,
-0.008476804,
-0.014156863,
0.0041984487,
-0.008463487,
-0.0077310055,
-0.0077975946,
0.0015956436,
-0.029032888,
-0.0065790126,
-0.015355468,
0.026489181,
-0.011499953,
0.020416247,
0.030045044,
0.00702516,
0.027261617,
0.024504824,
-0.0011852876,
-0.024944313,
-0.017206648,
0.025556933,
-0.009868518,
-0.0031480042,
0.0048643406,
-0.0012310677,
-0.028260455,
-0.032069355,
-0.029991774,
0.0068253926,
0.021095457,
-0.00801068,
-0.022533784,
-0.027994098,
-0.009442348,
0.007997362,
0.017473005,
0.0013026511,
0.012125893,
0.015248925,
0.00967541,
-0.01855175,
-0.008776456,
0.04935591,
-0.032575432,
-0.0033427775,
-0.009449007,
0.0041385186,
0.007338129,
0.029405788,
-0.01472953,
-0.021401767,
0.016500803,
-0.009602162,
-0.017885858,
0.010274713,
0.0029931844,
0.04195119,
0.023426078,
0.03499928,
-0.0064791287,
-0.010960582,
0.017100105,
-0.0075445557,
0.010088263,
0.0022390618,
0.022267427,
0.0026319379,
-0.003549204,
0.0089962,
0.012918304,
0.024345009,
-0.028500175,
0.023266265,
0.018658292,
-0.0054236897,
-0.014116909,
-0.005706694,
-0.044082046,
0.011899489,
0.008177153,
-0.02064265,
0.021628171,
-0.026515817,
0.0051773097,
0.037076864,
0.01355756,
-0.02354594,
0.019950124,
0.015062476,
-0.018405253,
0.01614122,
-0.013144707,
-0.011546566,
-0.005576845,
-0.0045946543,
-0.008243742,
-0.02096228,
0.02293332,
-0.0057166824,
-0.0017346485,
0.029538967,
-0.0019643812,
-0.00013130557,
0.0014999215,
-0.032255806,
-0.013564219,
-0.021867892,
-0.005933097,
0.011553225,
-0.014702894,
-0.0087165255,
0.0036624058,
0.014796119,
0.003149669,
-0.013477653,
0.019976757,
-0.017885858,
0.010427868,
-0.006385904,
-0.023026543,
0.03992688,
-0.0179924,
0.020069983,
0.030417943,
-0.007990703,
-0.008962906,
0.018125579,
0.0095355725,
0.0037523012,
0.04043296,
0.011799606,
-0.02126859,
-0.010261395,
-0.0004511418,
0.004894306,
-0.0124654975,
-0.016154539,
0.024544777,
0.036064707,
-0.001405032,
-0.0040586116,
-0.0058831554,
-0.029219339,
0.008110564,
-0.012618653,
-0.028846439,
0.010940605,
-0.026169553,
-0.0075578736,
0.030924022,
-0.029485695,
0.0027185038,
-0.006951912,
-0.019563906,
-0.000053791584,
-0.02495763,
0.025437072,
-0.0044215224,
0.005819896,
0.023745706,
-0.011286869,
0.0061095585,
-0.012192481,
-0.007677734,
0.004924271,
-0.0023938816,
-0.008436851,
0.031110471,
-0.016261082,
-0.022134248,
0.019057827,
0.029538967,
-0.009036154,
0.0045313947,
-0.01811226,
-0.012964916,
-0.012578699,
-0.0020775828,
0.035185732,
0.0024871065,
-0.025037536,
0.007105067,
-0.007817571,
0.004238402,
0.005686717,
-0.007970726,
-0.029725416,
-0.034120303,
-0.0014258411,
-0.010700883,
-0.000983023,
0.007770959,
0.011133714,
-0.01207928,
-0.0061694887,
0.0017795962,
-0.024691273,
0.028766531,
0.017712725,
0.031376828,
-0.00029070346,
0.01602136,
-0.018138897,
-0.028127275,
0.0051107206,
0.0055568684,
-0.017180013,
-0.01780595,
0.008776456,
0.009542231,
-0.00200267,
-0.04029978,
0.030284766,
0.004071929,
0.0018378617,
-0.0006742156,
-0.0013409399,
0.032575432,
0.009222603,
0.00068295543,
-0.002883312,
0.0021658135,
0.01688702,
-0.025836607,
0.008210448,
-0.014183498,
-0.027328206,
0.016807113,
-0.0067022024,
0.015368786,
-0.0100216735,
0.0008186309,
-0.028233819,
-0.018378617,
-0.006322644,
0.021028867,
0.011373434,
-0.00095971674,
0.005373748,
0.006758803,
0.01435663,
0.014196816,
-0.011579861,
0.012026008,
-0.0037822663,
-0.015275561,
-0.012019349,
-0.0031713103,
-0.008836386,
0.045893274,
0.020602698,
-0.00499086,
0.0048643406,
-0.0058232252,
-0.07713693,
-0.008743161,
0.013890506,
-0.0011728022,
0.026156235,
0.028420268,
0.00603964,
0.009102743,
0.010074945,
0.026782174,
-0.027434748,
-0.02058938,
-0.005846531,
-0.013537583,
0.029432423,
-0.015248925,
-0.03739649,
-0.0012443856,
0.014982569,
-0.010834062,
-0.011926125,
0.010887333,
0.0058764964,
0.009968403,
-0.033907216,
0.018818107,
-0.00006835797,
-0.030124951,
-0.0030348026,
-0.041125488,
-0.000640921,
0.000606794,
-0.014662941,
-0.0001279761,
-0.010241418,
0.0061028996,
0.014076956,
-0.010747496,
0.008789774,
-0.019124417,
-0.0031629868,
-0.0257567,
0.0037822663,
0.016101267,
0.016860384,
0.025916515,
0.015595189,
0.0050174957,
0.0041318596,
-0.0008639948,
-0.0055368915,
0.009668751,
-0.010334643,
-0.0016597357,
-0.0061761476,
0.0014749507,
-0.008416874,
-0.012811761,
-0.0009971731,
-0.012611994,
-0.013237932,
-0.027155073,
0.024251785,
0.002577002,
-0.037929203,
-0.012971575,
-0.0030298084,
-0.009722022,
0.010694224,
-0.00085400644,
0.024131924,
-0.022467194,
-0.0011977731,
0.001713007,
-0.011173666,
0.0066689076,
0.00961548,
0.0003728995,
-0.008803092,
0.0032029403,
0.1898591,
0.0039287624,
-0.014995887,
0.019790309,
0.0025720077,
0.022520466,
0.03752967,
0.013510947,
-0.01602136,
0.047464777,
-0.019137735,
-0.011306846,
0.005573516,
0.013144707,
0.02624946,
0.0051107206,
-0.0118062645,
-0.003204605,
0.0019677107,
-0.021654805,
0.028846439,
-0.024065334,
-0.01731319,
-0.010314666,
0.015248925,
0.011047147,
0.004894306,
-0.001213588,
0.008609983,
0.0075645326,
-0.009582185,
0.01472953,
-0.020323021,
0.012205799,
-0.013018187,
-0.0095355725,
-0.013377769,
-0.037076864,
0.01158652,
-0.0016614004,
-0.018831424,
-0.012192481,
-0.033134785,
-0.029592238,
-0.0075046024,
0.016980244,
-0.0029598896,
-0.014756165,
-0.012292366,
0.005180639,
-0.02865999,
-0.016873702,
0.0036124638,
0.00918265,
-0.0033660838,
0.0011786288,
0.045067567,
0.01115369,
0.00030755883,
-0.00035708456,
0.004431511,
0.015874865,
-0.025610205,
0.021628171,
-0.010234759,
0.011087101,
-0.020096619,
0.016540756,
-0.025903197,
0.011726357,
-0.0066222954,
-0.022387287,
-0.03044458,
-0.0061295354,
0.0050974027,
-0.011593179,
0.031723093,
0.011746334,
0.01361749,
0.008889657,
-0.013917142,
-0.015395422,
-0.011446683,
0.012811761,
-0.014409902,
-0.037156772,
0.007990703,
0.0048277164,
0.0010129882,
0.025863243,
-0.0018145555,
-0.0058099073,
0.013264568,
-0.02106882,
-0.0030897385,
-0.014556398,
0.0013517607,
0.0070717726,
-0.03401376,
0.01651412,
-0.03049785,
0.048903104,
0.0065723537,
0.0035392158,
0.019177688,
-0.010953923,
-0.012671923,
0.012412226,
-0.0040819175,
-0.011653109,
0.027674468,
-0.047464777,
0.0073714238,
-0.00014847309,
-0.01725992,
0.021428403,
0.01472953,
-0.023998745,
0.02439828,
0.003629111,
0.015595189,
-0.02526394,
0.009515596,
0.020229798,
-0.0018728211,
-0.027261617,
-0.041631564,
-0.010620977,
-0.020189844,
-0.033374503,
0.007178315,
-0.0321759,
0.014569716,
0.016034678,
-0.000096814445,
-0.025463708,
-0.008277037,
-0.0111670075,
0.013344474,
0.030924022,
0.009502278,
-0.02643591,
-0.012964916,
0.002360587,
-0.0031679808,
-0.012798443,
0.0061361943,
0.0026236142,
-0.020309703,
-0.011306846,
-0.0053371238,
-0.011952761,
0.005180639,
-0.006562365,
0.013297862,
-0.012398908,
-0.032868426,
-0.04192456,
-0.013178001,
0.016008042,
-0.005586833,
0.022666961,
0.0033744075,
-0.006798757,
-0.023732388,
0.018098943,
-0.16908328,
0.003912115,
0.030151587,
-0.030311402,
0.0140902735,
-0.015701732,
0.035505358,
0.019404091,
-0.008829727,
-0.0066888845,
0.032548796,
0.018019035,
-0.026409274,
-0.01916437,
-0.004308321,
0.01386387,
-0.015968088,
0.044641394,
0.02828709,
0.008916293,
0.020536108,
-0.02582329,
0.0020043347,
-0.018778153,
0.011906148,
0.004880988,
0.004221755,
0.022440558,
0.009908472,
0.0007087587,
0.0031646516,
0.00924258,
0.02477118,
-0.010960582,
0.00015024187,
-0.006539059,
-0.021428403,
-0.014876026,
-0.011393411,
0.010933946,
0.025184033,
-0.010248077,
-0.0055002673,
-0.0059297676,
-0.022001069,
0.019896852,
0.0063193147,
-0.02137513,
0.023199676,
-0.015462011,
0.036331065,
-0.021215318,
0.028739896,
0.0077842767,
-0.014196816,
0.006299338,
0.010008356,
-0.0018511796,
0.019324183,
0.009542231,
-0.002410529,
-0.028739896,
0.0028749884,
-0.0031846282,
0.012778467,
-0.036064707,
0.010620977,
0.018258758,
-0.004518077,
0.012052644,
-0.019763673,
-0.0076444396,
0.0060096746,
-0.02218752,
0.015435375,
0.006569024,
-0.003992022,
0.008869681,
-0.00807061,
-0.019270914,
-0.012305683,
0.028047368,
-0.017299872,
0.007258222,
-0.015462011,
-0.0012893332,
0.0007150015,
0.022786822,
0.0035891575,
-0.013324498,
0.0025753372,
-0.023226311,
0.010594341,
-0.009189309,
0.014609669,
-0.0009780288,
0.012045985,
0.0046545845,
0.008290355,
-0.022294063,
0.007944091,
-0.03156328,
-0.025490344,
-0.015701732,
0.0155685535,
-0.006878664,
0.0046379375,
0.008703208,
0.010967241,
-0.017539594,
-0.016567392,
0.007850866,
0.013071459,
-0.0043982165,
-0.004757798,
0.008902975,
0.014103591,
-0.019071145,
0.0060895816,
-0.009948426,
0.006332632,
0.0013742344,
0.016127903,
-0.009928449,
0.022587055,
-0.015142383,
-0.10297353,
-0.022706915,
0.009322487,
0.0014824419,
-0.0043848986,
0.016061313,
-0.0067821094,
0.016154539,
-0.00375896,
0.0261296,
-0.0022340675,
-0.0020176526,
-0.016687252,
-0.014782801,
0.021974433,
-0.022001069,
0.0026785503,
-0.02334617,
-0.029379152,
0.020296386,
0.005393725,
-0.009895154,
0.0021608192,
-0.008490122,
-0.007924114,
-0.014343312,
-0.019284232,
0.0071583386,
0.014156863,
0.019297548,
-0.00073206495,
-0.0053704185,
-0.002939913,
-0.018325346,
-0.00505412,
-0.0073714238,
-0.008956247,
-0.020136572,
0.028180547,
0.0015814934,
-0.0015332162,
0.018884696,
0.020402929,
-0.014636305,
0.004677891,
-0.0077310055,
-0.017393097,
0.010947264,
0.014489809,
-0.019057827,
-0.015661778,
0.0027035214,
-0.024438234,
0.008623301,
-0.010880674,
-0.0022257438,
-0.012372272,
0.016407577,
-0.006076264,
0.007264881,
0.02323963,
0.008083928,
0.0025037536,
0.01725992,
0.017446369,
-0.016380941,
-0.02144172,
-0.016407577,
-0.014569716,
-0.02680881,
-0.013577537,
0.0043349564,
-0.00001797388,
-0.011293528,
-0.018804789,
0.008523417,
-0.024478188,
-0.024944313,
0.0059830393,
-0.018258758,
-0.0100283325,
0.006019663,
0.015661778,
0.010807427,
0.026875399,
0.0063759154,
0.021348495,
0.0044847825,
-0.0023206335,
0.002175802,
0.00046903765,
0.05399052,
0.028020732,
-0.010933946,
-0.00012849634,
0.013317839,
-0.014489809,
0.000711672,
0.025730064,
0.003845526,
-0.027860919,
-0.031403463,
-0.05441669,
0.030657666,
0.021481674,
-0.012352295,
0.015142383,
-0.010394573,
-0.0008856363,
-0.01109376,
-0.017033515,
-0.0023023214,
-0.000083028404,
-0.0013484312,
-0.041311935,
-0.00597971,
-0.0038488554,
-0.015755003,
0.0019094452,
0.005460314,
0.042936713,
0.029618874,
-0.008530076,
0.0001564846,
0.0058831554,
0.006092911,
-0.00548695,
0.014929297,
0.010501116,
0.00042554658,
-0.020655967,
-0.008396897,
0.027021894,
-0.00677878,
-0.0012418885,
0.034280118,
-0.012918304,
-0.038115654,
0.021494992,
0.02791419,
0.01454308,
0.005586833,
-0.0176195,
-0.019617178,
0.023279583,
0.015129065,
-0.017473005,
-0.007864184,
-0.03433339,
0.008796433,
-0.0059830393,
0.0019427397,
0.00782423,
-0.0075445557,
0.0039520687,
-0.0077376645,
-0.0019094452,
0.020549426,
-0.006748815,
0.019111099,
-0.016008042,
-0.024891041,
0.018458525,
0.030950658,
-0.00064674753,
-0.010068286,
0.0155685535,
-0.017859222,
-0.009435689,
0.011373434,
-0.022773504,
-0.017180013,
-0.021708077,
0.01349763,
0.013331157,
0.022400605,
0.01737978,
-0.022786822,
-0.0009330811,
0.013297862,
-0.0015307191,
0.0056667402,
-0.008416874,
0.008756479,
-0.00795075,
0.019364137,
0.046053085,
0.030604394,
-0.013564219,
0.017979082,
-0.013564219,
-0.0039287624,
0.012472156,
-0.00040910736,
0.0044414992,
-0.011593179,
0.0075845094,
0.01749964,
0.023932157,
-0.006758803,
0.009975062,
0.030684302,
-0.005909791,
-0.007184974,
-0.01405032,
-0.028127275,
-0.0049775424,
0.033347867,
-0.02871326,
-0.030364672,
-0.0029848607,
0.0075578736,
0.006079593,
0.015302197,
-0.013823917,
-0.0006929438,
-0.02551698,
0.006705532,
0.001380061,
0.009708704,
-0.0016738859,
0.036890414,
-0.005446996,
0.020256434,
0.012172504,
-0.019550588,
0.009835224,
-0.0049442477,
0.02014989,
-0.023079814,
0.03332123,
-0.012831737,
0.012438862,
0.004411534,
-0.029725416,
-0.015368786,
-0.01614122,
-0.038062382,
0.01805899,
0.024185196,
-0.0044148634,
0.0799603,
-0.008709867,
-0.026182871,
-0.003209599,
-0.0032212522,
0.009402394,
0.0042750263,
0.0088829985,
0.009482301,
-0.036757234,
0.004288344,
0.00634595,
0.030231494,
-0.034972645,
-0.019310866,
0.0053704185,
0.0005556036,
0.033853948,
-0.022001069,
-0.023319535,
0.027035212,
-0.010008356,
0.028074004,
0.00499086,
-0.021095457,
-0.018391935,
0.021388449,
-0.01960386,
-0.015581871,
-0.028233819,
-0.025090808,
0.017752679,
-0.03931426,
-0.012605335,
0.032681976,
-0.02945906,
-0.0027334865,
-0.029778687,
0.014143545,
0.0018345322,
-0.01897792,
0.00677878,
-0.005020825,
0.0058498606,
-0.0041818013,
-0.032575432,
-0.015888182,
-0.003765619,
-0.022280745
] |
The small GTPases, Rab5 and Rac, are essential for endocytosis and actin remodeling, respectively. Coordination of these processes is critical to achieve spatial restriction of intracellular signaling, which is essential for a variety of polarized functions. Here, we show that clathrin- and Rab5-mediated endocytosis are required for the activation of Rac induced by motogenic stimuli. Rac activation occurs on early endosomes, where the RacGEF Tiam1 is also recruited. Subsequent recycling of Rac to the plasma membrane ensures localized signaling, leading to the formation of actin-based migratory protrusions. | [
-0.029129218,
-0.0019178714,
0.010554065,
-0.021134514,
-0.022638468,
0.03174135,
-0.011569893,
0.002608833,
0.0017546132,
-0.01538255,
0.032084357,
0.009102881,
0.0024175404,
0.01655669,
-0.014788883,
0.0040105446,
0.024168808,
-0.0052077714,
-0.0125923185,
0.021358788,
-0.015158275,
0.018311303,
0.007651697,
-0.038469564,
0.0034498598,
-0.010560661,
0.021992031,
-0.021094937,
-0.0123416595,
-0.034802027,
0.005751965,
-0.014472261,
-0.008021089,
-0.010184673,
0.004874659,
0.010039554,
0.032163512,
-0.0021998629,
0.0076187155,
0.0071899565,
-0.0007482667,
0.012922133,
-0.007994704,
0.0023961025,
0.009162247,
0.0057486673,
0.0024373294,
-0.02704479,
-0.017981488,
0.014485454,
0.01936671,
0.005108827,
-0.024393082,
-0.017862754,
-0.031609423,
-0.018773042,
-0.0022361425,
0.021200478,
0.00881924,
-0.018271724,
0.0069129122,
-0.0073020933,
-0.015725557,
0.023179365,
0.01660946,
0.017348243,
0.01753294,
-0.0032602164,
0.001328328,
0.0095316395,
0.027598878,
0.024498623,
-0.00042339938,
-0.0068073715,
0.0126384925,
-0.039762437,
-0.03261206,
-0.0131068295,
-0.0041622594,
0.026556665,
0.00028384663,
-0.009102881,
-0.0021965648,
0.04815292,
-0.0024373294,
0.006408296,
0.012091001,
0.0060389037,
-0.013667514,
0.022625277,
0.0059465556,
0.03686007,
0.0075791376,
0.02069916,
-0.0019788872,
0.0060751834,
-0.009215018,
0.018891776,
-0.009604199,
-0.025738725,
-0.0057090893,
0.022427388,
-0.012203137,
-0.015554053,
-0.015263816,
-0.005844313,
-0.022678047,
-0.012427411,
0.019023702,
-0.0076253116,
-0.03941943,
0.017308665,
0.0013299771,
-0.024868015,
0.014630572,
0.0072097452,
0.033245303,
-0.005972941,
-0.011556701,
-0.017493362,
0.0094854655,
0.020461693,
0.01769125,
-0.000851746,
0.038522337,
-0.0018238743,
-0.011965671,
0.00138687,
-0.010877283,
-0.0052605416,
-0.013865403,
0.015329779,
-0.019881219,
0.019102857,
-0.016530303,
0.015712364,
0.0019920797,
-0.016081756,
-0.020158263,
-0.027414182,
-0.0030524335,
0.03377301,
0.0032536204,
-0.00912267,
-0.000556562,
-0.0029122622,
0.018561961,
0.006292861,
0.012757226,
0.0005487289,
0.024036882,
-0.0069854716,
0.01186013,
-0.016028985,
0.003726904,
0.02852236,
-0.023232134,
0.023654297,
0.0006320071,
-0.03245375,
0.0048185904,
0.0107651455,
0.0075263674,
0.0035751895,
0.048443157,
0.025791496,
0.029920774,
0.01696566,
-0.003157974,
0.0001863452,
0.014788883,
0.006470961,
-0.023364061,
0.021147707,
-0.000020407273,
0.011682031,
-0.004244713,
0.015474898,
-0.026794132,
-0.005267138,
-0.010019765,
0.0009696547,
0.016213682,
-0.016952466,
-0.0027143734,
-0.005204473,
0.030131854,
-0.022717625,
-0.01116752,
-0.018152991,
-0.012829785,
0.015369357,
-0.006833757,
0.00005248689,
-0.6357769,
-0.00038918114,
0.014393106,
-0.016978852,
0.00037949282,
0.032928683,
0.010646413,
-0.0047559254,
0.01753294,
0.0067183217,
-0.03379939,
0.0293403,
0.006751303,
-0.0300527,
-0.019670138,
-0.022480158,
-0.0024670127,
-0.006658955,
0.036939226,
0.00010914799,
-0.030237395,
-0.008350904,
-0.017902331,
0.022466965,
0.022889128,
-0.0016581425,
0.01303427,
-0.028390434,
-0.008159611,
0.038812574,
-0.03153027,
0.016015792,
-0.015237431,
0.0052968212,
0.043377206,
0.009775703,
-0.008904992,
0.04656981,
0.007011857,
0.04733498,
-0.027651649,
0.008726892,
0.0075065787,
0.011972267,
-0.0068403534,
0.013489414,
-0.014076483,
0.02402369,
-0.011655645,
-0.024116037,
-0.000059830414,
0.0070712236,
-0.03137196,
0.009518447,
0.0084234625,
0.012091001,
0.019696523,
-0.0014058345,
-0.008133226,
0.02192607,
0.0017084392,
0.023522371,
-0.016015792,
-0.023561949,
0.004561335,
0.008034281,
-0.015474898,
0.0063819108,
0.0015872323,
0.032928683,
0.017255895,
0.0049933917,
-0.018430036,
0.020923434,
0.014709728,
0.030554017,
-0.011879919,
0.004838379,
0.00051451067,
0.0043304646,
0.01568598,
-0.0059828353,
-0.014749305,
0.0011485791,
0.0061708298,
0.008674121,
-0.025844267,
0.02213715,
0.00526384,
0.00024674248,
-0.004429409,
0.00631265,
-0.016807348,
-0.040316526,
-0.03643791,
0.009215018,
0.0057189837,
0.008476233,
-0.0064643645,
-0.007249323,
-0.016253259,
-0.003700519,
-0.002318596,
-0.004950516,
0.01916882,
-0.009439291,
-0.017559325,
0.008634544,
0.024617355,
-0.019947182,
-0.011345619,
-0.0041622594,
0.009069899,
-0.019274361,
-0.0026517087,
-0.015778327,
0.0068007754,
0.018482806,
0.011213694,
-0.02852236,
0.005455132,
-0.025910228,
0.012744033,
-0.001452833,
0.0064808554,
0.010244039,
0.008970955,
-0.018944547,
-0.013390469,
0.010230847,
0.0032156915,
-0.0014503594,
0.03298145,
-0.022889128,
0.032084357,
0.024366697,
0.021200478,
0.00695249,
0.0027143734,
-0.048364002,
-0.028786212,
-0.0053265044,
0.0038918112,
-0.015804712,
-0.0024274348,
-0.01538255,
-0.015013157,
-0.020382537,
0.022097573,
-0.0022674748,
-0.011490738,
-0.0038555318,
-0.0023202451,
0.014366721,
0.02841682,
-0.020765122,
-0.03419517,
-0.018997317,
0.0026236745,
-0.008463041,
0.003792867,
0.009571217,
-0.017466977,
0.011028998,
-0.006269774,
-0.008087052,
0.009854858,
0.001543532,
-0.010910264,
-0.027836345,
-0.0012565933,
-0.012077807,
-0.026240043,
0.020105492,
0.0038291465,
0.026160888,
-0.0060619907,
0.0057618595,
-0.023575142,
-0.0004271098,
0.0031761138,
-0.022414194,
-0.006470961,
-0.01086409,
0.026754554,
0.0087137,
0.026517088,
-0.002112462,
-0.014155639,
0.02233504,
-0.020672774,
0.019854834,
-0.0126253,
0.0073680566,
0.027730806,
-0.015606823,
0.04226903,
0.020791508,
-0.0002407646,
0.024261156,
0.0077242563,
-0.0043700426,
-0.0011527018,
0.002247686,
0.01390498,
0.007928741,
0.00858837,
-0.038311254,
0.009412906,
0.018667502,
-0.018496,
-0.0010760198,
-0.0014297459,
-0.0050329696,
0.00062334945,
0.006131252,
-0.009525043,
0.020606812,
-0.027203102,
-0.01290894,
0.0029996631,
-0.0006946718,
0.01936671,
-0.01788914,
-0.017678058,
0.012922133,
0.0038225504,
0.026266428,
-0.010963035,
-0.027123947,
-0.01040235,
0.011253271,
0.0052968212,
0.032928683,
-0.002518134,
-0.012565933,
0.0015954777,
0.00031126247,
0.03343,
0.0048548696,
0.019353516,
0.016662229,
-0.009162247,
0.0051154234,
-0.0123416595,
-0.007981512,
0.019050086,
0.027282257,
-0.0060257115,
0.033509154,
0.006217004,
0.036833685,
-0.017559325,
0.009841666,
-0.002086077,
-0.01098942,
0.018575154,
0.013080444,
0.0396569,
0.03266483,
-0.0022229499,
0.013456432,
0.020131879,
-0.027440568,
0.00051822106,
0.013759862,
0.007249323,
-0.010784935,
0.0058080335,
-0.0029353492,
-0.00981528,
0.004835081,
0.0059003816,
-0.036305983,
0.019274361,
0.010474909,
0.0067480053,
0.002407646,
-0.0018964335,
0.01788914,
0.010019765,
-0.0375197,
0.0034003877,
0.015408934,
-0.008232171,
-0.0077770264,
-0.034010474,
0.009386521,
-0.013614743,
0.018311303,
0.0035751895,
-0.0016919485,
-0.008502618,
-0.0025758515,
-0.023430023,
-0.008509215,
-0.0026533578,
-0.010732165,
0.029023677,
-0.005811332,
0.013773055,
-0.008350904,
-0.021820528,
-0.0022526332,
0.027783575,
0.010092325,
-0.0016061967,
-0.010131902,
-0.003108502,
-0.04722944,
-0.0039181965,
0.0009787246,
0.00029539014,
-0.036253214,
0.010211058,
-0.010481506,
0.006249985,
-0.018139798,
0.06353547,
-0.00058830663,
-0.023166172,
-0.019973567,
0.0053693806,
-0.013509203,
0.022889128,
0.03245375,
-0.007658293,
0.025105482,
0.0020333065,
0.0013011183,
-0.009940609,
-0.01420841,
0.008858818,
-0.016846925,
-0.0016449499,
0.0028809297,
0.0135751655,
-0.002590693,
0.015606823,
0.046754505,
-0.0067348126,
-0.0129815,
0.009663565,
-0.0017199827,
0.0075263674,
-0.0090633035,
0.0170712,
0.029683307,
0.0307651,
-0.0026401652,
0.026741361,
0.020211034,
0.014749305,
-0.025989383,
0.012427411,
0.0025494662,
-0.008172804,
0.0031299398,
0.008344308,
-0.050580356,
0.004495372,
0.0078034117,
-0.0044821794,
0.026385162,
0.0069129122,
0.0091094775,
-0.008904992,
-0.0017777003,
-0.012005249,
-0.0035488042,
-0.000068281915,
0.0021157602,
0.010092325,
-0.005890487,
0.04100254,
-0.0064874515,
-0.00435685,
-0.008113437,
-0.007889164,
0.0003355863,
-0.014129254,
-0.0051154234,
0.009327155,
-0.032849528,
0.008957762,
0.011127942,
-0.015659593,
-0.02325852,
0.0027968271,
-0.027335027,
-0.008496022,
-0.031002564,
-0.032796755,
-0.0052968212,
0.006813968,
-0.048786163,
-0.024221579,
-0.0030145047,
0.02131921,
0.026820516,
0.018522384,
0.01267807,
0.0003533138,
0.028284894,
-0.0028693862,
-0.016160911,
-0.013021077,
-0.03780994,
0.0076846783,
0.00013151355,
0.015765134,
-0.015250623,
-0.0144194905,
-0.0028561938,
0.018311303,
-0.0017496661,
0.01203823,
-0.025448488,
0.009274384,
0.015791519,
0.014709728,
0.0017744021,
0.0009721283,
0.004647087,
-0.020606812,
-0.0208047,
-0.000054831664,
-0.009755913,
-0.02474928,
-0.0105936425,
-0.002498345,
-0.0042348183,
-0.020606812,
-0.0057651578,
-0.0031447816,
-0.017678058,
-0.02131921,
0.0020728842,
0.0074867895,
0.036147673,
0.010362772,
0.022717625,
0.009742721,
-0.019854834,
-0.009241403,
-0.014999964,
0.027150331,
0.007156975,
-0.04105531,
0.017453784,
0.0022971581,
-0.0016070212,
-0.0152770085,
-0.008331114,
0.0011601226,
0.016437955,
0.005095634,
-0.03282314,
-0.021899683,
0.0046965587,
-0.011141134,
-0.0018354178,
-0.016688615,
-0.0105936425,
-0.0052374545,
0.0117018195,
0.0015880569,
-0.014406298,
-0.0051615974,
-0.028786212,
0.007941933,
0.021530291,
0.00026220255,
0.015554053,
0.015065927,
-0.0019112752,
-0.036411524,
-0.02653028,
-0.02519783,
-0.042902272,
-0.007011857,
-0.0077770264,
0.022110766,
0.0327176,
0.04401045,
0.009650373,
0.018746657,
0.027361413,
0.014063291,
0.004541546,
0.009168844,
0.016253259,
-0.026873287,
0.016583074,
-0.0017348244,
0.0048416774,
0.028944522,
-0.011695223,
0.016134527,
0.0010958087,
-0.010534276,
-0.011048786,
0.019313939,
-0.016451148,
-0.025619991,
0.035356116,
0.0018040854,
-0.011510527,
-0.023588335,
0.011761186,
0.00011017866,
0.009881243,
-0.01656988,
-0.023759838,
0.019393094,
-0.021306017,
0.037335005,
-0.025369333,
-0.0038720225,
-0.0028677373,
-0.023746645,
-0.01009892,
-0.0076714857,
0.0021800739,
0.0039874576,
-0.0026038857,
0.013199178,
-0.014920809,
0.006012519,
-0.011101557,
0.001136211,
-0.0109366495,
-0.0019574491,
-0.027387798,
-0.026266428,
-0.022717625,
-0.014366721,
-0.036833685,
-0.005379275,
0.024195192,
-0.021754567,
0.004406322,
0.008245363,
-0.011800763,
0.020738738,
-0.0070316456,
0.011444564,
-0.001977238,
0.018733464,
0.008786259,
0.0041688555,
-0.016477533,
-0.018166184,
-0.015580438,
0.019247975,
0.03424794,
0.031213647,
0.010026362,
-0.016622651,
-0.011391793,
0.014828461,
-0.007645101,
-0.03833764,
0.023482794,
-0.013680707,
0.007922145,
-0.01221633,
0.0049571125,
-0.021833722,
0.025883844,
-0.0062104072,
0.00968995,
-0.009544833,
-0.008047475,
-0.038865343,
0.03889173,
-0.004630596,
0.031556655,
0.0030738714,
-0.0004943095,
0.024195192,
-0.0058509097,
0.0155276675,
0.0028017743,
-0.018284917,
0.012097596,
0.018575154,
-0.0149340015,
0.021437943,
0.022902321,
-0.0056266356,
-0.017308665,
-0.017506555,
0.043166123,
0.0131530035,
-0.033561926,
-0.0017364734,
-0.003588382,
0.0029188585,
-0.011339024,
-0.007895759,
0.006385209,
-0.022889128,
-0.008918185,
0.024683319,
-0.031108106,
-0.016490726,
-0.02923476,
-0.0023103508,
-0.0074406154,
-0.034775645,
-0.010013169,
0.005013181,
-0.0348548,
-0.01502635,
0.011767782,
0.01682054,
0.007203149,
0.0013926418,
0.02386538,
-0.0015303394,
0.029999929,
-0.025857458,
0.015052735,
-0.0035949782,
0.00043576743,
-0.015606823,
-0.0018420141,
-0.013918173,
-0.02627962,
0.018931353,
-0.00713059,
-0.02939307,
0.00057428953,
-0.01081132,
0.0131530035,
0.0031019056,
-0.005333101,
0.014762498,
0.0032107444,
0.023746645,
0.02341683,
0.0010018116,
-0.0053924676,
-0.024247963,
0.013311314,
0.024762474,
-0.033403616,
-0.006470961,
0.024683319,
-0.0132321585,
0.0018519085,
-0.019182013,
-0.012737437,
-0.018561961,
-0.0144194905,
-0.0062301964,
-0.0024884506,
0.012645089,
-0.017678058,
-0.011840342,
0.0025758515,
0.003746693,
-0.016715,
-0.0070712236,
-0.023680683,
-0.00558376,
0.008238766,
-0.0099999765,
0.0024851523,
-0.00055491296,
-0.009300769,
-0.027651649,
-0.009848261,
-0.031081721,
0.024010498,
-0.010072536,
-0.02448543,
0.0032437257,
-0.007928741,
-0.036279596,
-0.0021388473,
-0.005425449,
-0.008258556,
0.004838379,
-0.011372005,
-0.02034296,
-0.0012335064,
0.0028034234,
0.0010826162,
0.01249997,
0.013218966,
0.00976251,
-0.018548768,
0.00001025517,
0.018007873,
-0.029313914,
-0.012631896,
0.03926112,
-0.0101253055,
-0.0046503847,
0.014525032,
-0.01865431,
0.018205762,
-0.010158287,
-0.006474259,
0.019340323,
0.018403651,
0.007513175,
-0.028205737,
-0.0073284786,
0.029656922,
0.017282281,
-0.02494717,
-0.006926105,
-0.0052110692,
0.014366721,
-0.0046272976,
-0.003990756,
-0.019261168,
-0.0058706985,
-0.015224238,
0.014920809,
0.030791484,
0.0033228814,
0.014551417,
0.017744021,
-0.018152991,
0.0018123308,
0.0036609413,
-0.028495975,
0.0010496348,
0.0027902308,
-0.014538224,
-0.008469637,
0.009439291,
-0.0033525645,
-0.017519748,
-0.006246687,
0.013931366,
0.024036882,
-0.015817905,
0.009373329,
-0.0035850839,
-0.0124669885,
-0.001566619,
-0.0009457431,
-0.00046668755,
-0.019656945,
0.005949854,
-0.0027770384,
-0.015316586,
-0.014551417,
-0.005003286,
-0.017928718,
0.02279678,
-0.030211011,
-0.0068007754,
-0.01804745,
0.016622651,
0.19546127,
-0.007011857,
0.000839378,
0.002434031,
-0.006470961,
-0.019089665,
0.0115303155,
-0.025844267,
0.006520433,
-0.013469625,
-0.0077176597,
0.021556677,
-0.017928718,
-0.009313962,
0.0017183337,
0.0034234747,
-0.038627878,
-0.0047097513,
-0.035646353,
0.0152770085,
0.023799416,
-0.018733464,
0.002818265,
0.0019821853,
0.046332344,
-0.0066391663,
-0.020791508,
-0.019511826,
0.012770418,
0.008113437,
-0.035092264,
-0.0019590983,
0.006586396,
-0.008153015,
0.017097585,
0.008403674,
-0.018535577,
-0.008251959,
0.012671474,
0.019300746,
-0.007816604,
0.00032321824,
0.0047493293,
0.002018465,
-0.013014481,
0.0012310327,
-0.014630572,
-0.027598878,
0.00449867,
0.008561985,
-0.064485334,
0.018073836,
0.0010768444,
0.0025395718,
-0.006744707,
-0.018878583,
0.0024966958,
0.006157637,
-0.004683366,
0.041371934,
-0.023443216,
0.00046957342,
-0.01513189,
0.012691263,
-0.02315298,
0.022519736,
-0.021292826,
0.005474921,
0.023324482,
-0.037282232,
-0.0008649386,
0.01890497,
-0.019102857,
0.0026616033,
-0.0036147672,
-0.014788883,
0.006362122,
0.014511839,
0.029683307,
0.036886457,
0.013918173,
0.030897025,
-0.026345585,
-0.025897035,
0.001285452,
-0.019854834,
0.013027674,
0.007156975,
-0.011695223,
0.017915525,
0.007519771,
-0.025448488,
-0.0026764448,
-0.0006827161,
0.012532952,
-0.025211021,
-0.0052968212,
0.0008414393,
-0.0104221385,
-0.011365408,
-0.018073836,
0.09461719,
0.042612035,
0.01237464,
-0.0174274,
0.0015080769,
0.012110789,
0.014564609,
0.004135874,
-0.03010547,
0.011833745,
-0.013185984,
-0.00558376,
0.0010273722,
-0.013331103,
0.003268462,
0.011180712,
-0.002018465,
0.05337718,
-0.004086402,
-0.014749305,
-0.028707055,
0.003977563,
0.018561961,
-0.0051220194,
-0.0063654203,
-0.026846902,
-0.007994704,
0.012282292,
-0.035303347,
-0.015672786,
0.019459058,
-0.010435332,
-0.008040878,
-0.0007482667,
-0.010191268,
0.013865403,
-0.018007873,
-0.0051846844,
-0.0013431696,
-0.012275697,
0.024459045,
0.038284868,
0.025290178,
-0.008185997,
-0.00030981953,
0.011912901,
0.017664867,
-0.039736055,
-0.01660946,
0.00076970464,
-0.0174274,
-0.0037170097,
-0.006652359,
0.01609495,
-0.03393132,
-0.008106841,
-0.03899727,
0.012005249,
0.020158263,
-0.03026378,
-0.0151055055,
0.02050127,
-0.019498635,
-0.004241415,
-0.0074867895,
-0.16538219,
0.013080444,
0.010831109,
-0.02612131,
0.01116752,
0.025791496,
0.0014866389,
0.008496022,
-0.03730862,
-0.004182048,
0.04683366,
0.014393106,
-0.04857508,
-0.005613443,
-0.004224924,
0.005570567,
-0.001408308,
-0.0047394345,
-0.0035949782,
0.014023714,
0.010290213,
-0.046965588,
0.009069899,
-0.0066952347,
-0.00759233,
-0.0141688315,
-0.009755913,
-0.030237395,
0.0012697859,
-0.0016952467,
-0.008931377,
0.018984124,
0.037915476,
-0.0021240055,
0.012453796,
-0.0026203764,
-0.017770406,
0.0097822985,
-0.015461705,
0.016279645,
0.039445817,
0.0068535456,
-0.0059399595,
-0.005362784,
-0.025276985,
0.03010547,
-0.0029848213,
0.005448536,
0.008232171,
-0.0060290094,
0.0077704303,
-0.024445852,
-0.005131914,
0.01845642,
0.029762462,
0.027651649,
0.017414207,
0.03377301,
-0.0068535456,
-0.009861454,
-0.002407646,
0.006104867,
0.050316505,
-0.017097585,
-0.00010476764,
-0.027678035,
-0.0047955033,
-0.009478869,
-0.036622606,
0.023021054,
0.010415543,
0.0051681935,
-0.011906304,
-0.03377301,
0.006972279,
0.018891776,
-0.018087028,
0.0037565874,
0.005897084,
-0.0082981335,
-0.014907616,
0.024142424,
-0.019802064,
-0.019670138,
-0.012790207,
-0.007203149,
-0.008034281,
-0.008489426,
-0.004386533,
0.018430036,
0.019973567,
-0.020488078,
0.01753294,
-0.017928718,
0.020092301,
0.020989396,
0.0049472176,
-0.016899696,
-0.007110801,
-0.023377253,
0.014102869,
-0.0115303155,
-0.006833757,
0.0067249183,
0.040553994,
0.0016729842,
0.016490726,
0.0075263674,
0.049366638,
-0.012302082,
0.016886504,
-0.0033476173,
0.00037248427,
0.022361424,
-0.0014816917,
0.023522371,
0.0002673559,
0.0043601478,
0.00036444503,
-0.019155627,
0.061477426,
-0.019010508,
-0.0078297965,
0.005158299,
0.011279657,
-0.035303347,
-0.13277014,
-0.018403651,
0.02443266,
0.011662241,
-0.013238755,
0.000054419397,
0.0045547388,
0.018746657,
0.0074208267,
0.027651649,
-0.027941886,
0.00088967464,
-0.002181723,
0.00039969396,
0.008799451,
0.006705129,
0.012645089,
-0.025395717,
-0.035303347,
0.025276985,
-0.008212382,
-0.01032979,
0.00038979953,
0.0069392975,
-0.00074249494,
-0.0127638215,
-0.020118685,
0.016622651,
-0.0070316456,
0.001113124,
-0.0010479856,
-0.015778327,
0.02923476,
-0.005676108,
0.0066391663,
-0.006424787,
-0.0050461623,
-0.02647751,
0.040765073,
0.006682042,
-0.004251309,
0.014775691,
0.010930053,
-0.009663565,
0.0025098885,
-0.02386538,
-0.0006184022,
0.017849563,
0.020092301,
-0.01788914,
-0.018324494,
-0.02770442,
-0.038469564,
-0.036015745,
0.016622651,
-0.012381237,
-0.0117348,
0.038627878,
0.005587058,
0.0054683248,
0.00677439,
-0.0061609354,
0.02841682,
0.0024224876,
0.03179412,
-0.03137196,
-0.0024356802,
-0.03490757,
0.036174055,
0.002295509,
-0.008113437,
-0.011794168,
-0.00024365047,
-0.0017430697,
-0.018179376,
0.011266464,
-0.009709739,
0.002452171,
-0.012236118,
-0.001577338,
-0.015791519,
-0.024577778,
0.018878583,
-0.010672798,
0.025013134,
0.0024999941,
0.002816616,
-0.014643765,
0.0013002937,
-0.003021101,
-0.0034927358,
0.036886457,
0.011985459,
-0.025804687,
-0.013707091,
0.027440568,
-0.004624,
0.004844975,
0.0025593606,
0.016688615,
-0.011972267,
-0.010441928,
-0.051952384,
0.03543527,
-0.010290213,
0.0068997196,
0.018192569,
-0.016200488,
0.004241415,
-0.029604152,
-0.0049637086,
0.032585673,
-0.028654285,
0.0018255233,
0.019736102,
-0.010112113,
-0.020936625,
-0.028284894,
0.034485407,
-0.016715,
0.0033459684,
0.027255872,
-0.01344324,
0.003090362,
0.019604174,
0.016451148,
0.017519748,
-0.0065732035,
-0.006141146,
0.023100208,
-0.019604174,
0.01758571,
0.0026929355,
-0.040580377,
0.0028479483,
0.004228222,
-0.0043964274,
0.003294847,
-0.00999338,
0.01040235,
0.014656957,
0.021886492,
-0.010930053,
-0.028469589,
0.0070712236,
-0.016583074,
-0.014393106,
0.014868039,
-0.033456385,
-0.0018222253,
-0.017598903,
-0.012196541,
0.020923434,
0.016385185,
0.0025395718,
-0.02519783,
0.0048779566,
-0.0069392975,
0.0101253055,
0.008984148,
-0.0059993262,
-0.019102857,
0.020817893,
0.021886492,
0.024828438,
0.0068469495,
0.00014408772,
0.0059366613,
-0.031820506,
-0.0008298958,
0.0052143675,
-0.041583017,
-0.028311279,
-0.0009680056,
0.036147673,
0.013370681,
0.02693925,
0.012156963,
-0.013561973,
-0.00912267,
-0.0122691,
0.021873299,
0.004538248,
0.0080013005,
-0.014247987,
0.00015150855,
0.03554081,
-0.00051615975,
0.013179388,
0.00828494,
-0.009129266,
-0.000038933573,
-0.0077176597,
0.018984124,
0.010052746,
0.016068563,
-0.007150379,
0.032638445,
-0.0026517087,
0.017506555,
0.02023742,
0.020949818,
-0.0027143734,
-0.002655007,
0.0015253922,
-0.021794144,
0.016846925,
0.027941886,
-0.031213647,
-0.033614695,
-0.0245382,
-0.008984148,
0.0012887502,
-0.010006572,
0.03221628,
0.0072097452,
-0.012941922,
0.005082442,
0.02203161,
-0.01313981,
0.0034828414,
-0.0031695175,
0.0055276914,
0.019247975,
-0.015791519,
0.0048647644,
0.0061708298,
0.0068073715,
0.032532904,
-0.023495987,
0.026569858,
-0.007908952,
0.017968295,
-0.029551381,
-0.030633172,
-0.004172154,
-0.007546156,
0.011695223,
0.006715024,
0.01063322,
-0.04999988,
0.093772866,
0.0058179284,
-0.0007144607,
0.013733476,
-0.01467015,
0.025844267,
0.017717635,
0.03353554,
-0.010771742,
-0.03031655,
-0.0057849465,
-0.0127638215,
0.01426118,
-0.015804712,
-0.006065289,
0.003677432,
-0.00031352992,
0.008509215,
-0.004591018,
-0.014947194,
0.011002612,
-0.0070844158,
-0.010646413,
0.029050063,
-0.01594983,
-0.014129254,
0.016213682,
0.018522384,
0.0014371668,
-0.02775719,
0.019340323,
-0.00019252923,
-0.04614765,
-0.009379925,
-0.0070844158,
-0.019960376,
-0.012236118,
0.0070910123,
-0.007631908,
0.007559349,
-0.004406322,
-0.01717674,
-0.006193917,
-0.032743987,
-0.0006031483,
0.014063291,
0.010791531,
0.012605511,
-0.012018441
] |
The aim of the present study was to analyze the stem cell marker, Nanog gene, for the diagnosis and prognosis of lung cancer cases, and to study its application in the diagnosis of lung cancer. In total, 100 patients diagnosed with lung cancer between April, 2013 and May, 2015 were included in the present study. The patients were randomly divided into group A (lung cancer) and group B (squamous cell lung carcinoma). RT-PCR was used to detect the cancer and adjacent tissues, and Nanog gene expression was detected in groups A and B in cells. The results showed that, analysis of Nanog | [
-0.031116242,
0.016347205,
0.019635059,
-0.012395206,
-0.012309722,
-0.0049843853,
-0.025382226,
0.00092799653,
-0.059181355,
0.009666288,
0.0013044557,
-0.0020927184,
-0.0018494173,
0.012809476,
-0.011053762,
0.004136119,
0.025171803,
-0.035982262,
-0.019069549,
0.0033470343,
-0.018227857,
0.005168505,
-0.007825091,
-0.022567824,
-0.016189389,
0.018977487,
0.021581467,
-0.039270118,
0.007003127,
-0.006779553,
0.006431041,
0.014650674,
-0.025684709,
-0.0019431212,
-0.008568145,
0.003669244,
0.012178208,
0.005615653,
0.03382543,
-0.023685694,
0.010534281,
0.012125602,
0.007200398,
-0.01405886,
-0.027986206,
-0.0120993,
0.012645083,
-0.014940005,
-0.017912224,
0.0021666952,
0.003335527,
0.008844324,
-0.021581467,
-0.012276843,
-0.012125602,
-0.016689142,
0.0045339493,
0.013808983,
-0.012520145,
-0.03251029,
-0.009810953,
0.00043522957,
-0.020779232,
0.01271084,
-0.000051655254,
0.009048171,
-0.004925204,
0.01992439,
0.0065855696,
0.008324844,
0.04542498,
0.0218708,
-0.0016094041,
-0.0038171974,
0.00402762,
-0.00666119,
-0.029406559,
-0.019529847,
-0.010310708,
0.010087133,
0.017859617,
-0.022804549,
0.0061943154,
0.0049284915,
0.017399319,
0.02096335,
-0.017557135,
0.002054908,
0.009429563,
-0.015150427,
0.022936063,
0.036087476,
0.021712981,
-0.0009937536,
-0.02010851,
0.026473792,
-0.0074700024,
0.010961702,
0.011921755,
-0.045030437,
-0.008798295,
0.0049712337,
0.00082073035,
-0.005369064,
-0.0107841585,
0.009166534,
0.025434831,
-0.004343254,
0.023133334,
-0.0054348214,
-0.012513569,
0.031984236,
-0.0051487777,
-0.010692098,
0.04929149,
-0.017636044,
0.018319918,
-0.0055137295,
-0.013072504,
0.0035048514,
0.030879516,
0.014295585,
0.03229987,
-0.03222096,
0.008173603,
-0.004639161,
-0.04024332,
-0.014098314,
-0.015965814,
-0.0003756372,
0.010073982,
0.013585409,
0.022686185,
0.031510785,
-0.0013398001,
-0.010343586,
0.009705742,
-0.014703279,
-0.028433353,
-0.0428473,
-0.014085162,
0.041689977,
0.014769036,
-0.008245936,
-0.009501895,
0.0001703519,
0.02020057,
0.0011614341,
0.02988001,
-0.0011285556,
-0.0059871804,
-0.019582452,
0.0097517725,
0.00791715,
-0.00066044746,
0.010540857,
0.021989161,
0.014940005,
-0.029906312,
0.007502881,
-0.0044616167,
-0.0074700024,
0.017359864,
0.020279478,
0.0019496969,
0.034325186,
0.022765094,
-0.010600038,
-0.021726133,
-0.014466554,
-0.009008718,
0.018004283,
-0.021805042,
0.014729582,
0.0013389782,
-0.009699167,
-0.013887892,
0.0014959732,
-0.018582946,
-0.025382226,
-0.007450275,
0.035456207,
0.010988005,
-0.011343093,
-0.022962365,
0.003623214,
0.028617473,
-0.0011647219,
0.010225223,
-0.019779725,
0.00012822627,
0.0040243324,
0.020621415,
-0.006089104,
-0.63758045,
-0.037876066,
-0.004852871,
0.015900057,
0.02447478,
0.01964821,
0.0054709874,
-0.0078053633,
-0.030143037,
0.014926853,
-0.014479705,
0.004566828,
0.002617131,
0.0016636536,
-0.008607599,
-0.022252189,
-0.02318594,
0.007200398,
0.026881486,
-0.0049087647,
-0.047897443,
0.00871281,
0.018398825,
0.030011524,
-0.018924883,
0.041795187,
0.023330605,
-0.018293615,
0.013559106,
0.052579347,
-0.042110823,
0.016794354,
-0.0002529592,
0.0063652834,
0.031142544,
-0.008982414,
-0.01609733,
0.012079572,
0.012875233,
0.025369074,
0.003021537,
0.0044155866,
0.0036823954,
-0.016768051,
-0.030590186,
0.016557628,
0.013243472,
0.015110972,
-0.0045503885,
0.00805524,
-0.0034785485,
0.03295744,
-0.017175745,
0.0072595794,
0.004543813,
-0.014361342,
0.006963673,
-0.021397348,
0.026934093,
0.015860604,
-0.0034949877,
0.0047279326,
-0.0024806852,
-0.040190715,
0.021213228,
0.022449462,
-0.012401782,
0.0050402787,
0.015768543,
0.0017507818,
0.016544476,
0.033667617,
-0.013414441,
0.018596098,
0.028512262,
0.043241844,
-0.015505515,
-0.020805534,
-0.0014063792,
-0.0046457364,
0.014216676,
-0.011014308,
-0.02877529,
0.008245936,
0.0050041126,
-0.004948219,
-0.025303317,
0.009429563,
-0.0036823954,
0.016873263,
0.00008137436,
0.007976332,
-0.014308737,
-0.03158969,
-0.008318269,
0.026763124,
-0.0066381753,
-0.0054709874,
0.008120997,
-0.03808649,
-0.036639836,
-0.010238375,
0.015676484,
-0.019358879,
0.03158969,
0.008226208,
-0.010968278,
0.0077264546,
0.00407365,
-0.036534622,
-0.009528198,
-0.00963341,
0.012224237,
-0.022778247,
-0.014400796,
-0.021818193,
-0.001386652,
0.019806027,
0.004099953,
-0.024159145,
0.0027108348,
-0.014413948,
0.0070228544,
0.016320903,
0.024251204,
-0.0026516535,
-0.01480849,
-0.010212071,
0.015623878,
-0.021252682,
-0.0043925717,
-0.030853214,
0.016057875,
-0.029538073,
0.028696382,
-0.013716923,
0.0045306617,
0.005079733,
-0.006467207,
-0.009896438,
-0.031037332,
-0.001274865,
0.018241009,
0.014190374,
-0.00072456064,
0.0011375971,
-0.031984236,
-0.0098898625,
-0.006740099,
0.03650832,
-0.00903502,
0.00205984,
-0.015374001,
0.028985713,
0.0042873602,
-0.00056304486,
0.0075226077,
-0.01974027,
0.012559598,
-0.014729582,
0.0008515539,
0.028144022,
0.010185769,
-0.034772333,
-0.003042908,
-0.015005762,
-0.009396684,
0.033667617,
0.0042018765,
-0.03806019,
-0.000021460948,
-0.018977487,
-0.012697688,
0.0051586414,
0.015702786,
-0.008528691,
-0.0039552874,
-0.008541842,
0.012040118,
-0.017649196,
-0.0034818365,
-0.03485124,
0.008107846,
0.014834793,
0.0015748816,
0.038586244,
0.02663161,
0.001767221,
0.011744211,
0.02076608,
-0.024145992,
0.013282927,
-0.016649688,
0.027460149,
0.028222932,
-0.009021869,
0.015032064,
-0.014427099,
-0.0007434658,
0.023330605,
-0.017017927,
-0.0006690781,
0.0055005783,
-0.008140724,
0.0035443057,
-0.010882794,
0.004948219,
0.0049778097,
-0.0044188746,
-0.012204511,
0.017004777,
0.018477734,
-0.0077527575,
-0.008502388,
-0.0009469017,
0.005319746,
-0.0013496637,
-0.01658393,
-0.0026713805,
0.0015321395,
-0.007851393,
0.022870306,
0.007608092,
-0.01042907,
0.0015592644,
0.014111466,
-0.007943453,
0.024224902,
0.0013850081,
-0.016873263,
-0.015189881,
0.014335039,
0.005711001,
0.011836271,
0.016833808,
0.01006083,
0.01926682,
-0.00689134,
0.0059904684,
0.008226208,
-0.015623878,
-0.0038895302,
0.005618941,
-0.00034440262,
0.0076672733,
-0.008364298,
0.028196627,
0.010376465,
-0.00030022208,
0.0026220628,
-0.008232784,
0.00935723,
-0.020989655,
-0.00072373863,
-0.0071477927,
-0.03564033,
0.0014080231,
0.019016942,
0.038744062,
0.016452417,
0.032168355,
-0.0043465416,
-0.0017721528,
-0.013151412,
-0.008022361,
0.0052408376,
0.018924883,
-0.0053592003,
-0.01462437,
0.011099792,
-0.000076442586,
0.011533788,
0.02840705,
-0.0298011,
0.0024560262,
0.012914686,
0.02337006,
0.004994249,
0.016044723,
0.012454388,
-0.0062469207,
-0.003853364,
0.037876066,
0.02607925,
-0.0103698885,
-0.02664476,
-0.0062567843,
0.000013356903,
-0.02811772,
-0.015807997,
0.014913701,
0.017833315,
0.0029492043,
0.0030577034,
-0.0111984275,
-0.0026532975,
0.0041854368,
-0.017175745,
0.0059641656,
0.0018214706,
0.011553516,
-0.010113436,
-0.002774948,
-0.02681573,
0.01992439,
0.017754406,
-0.008265663,
-0.013414441,
-0.008686508,
0.0027157667,
-0.02047675,
-0.029722191,
-0.00689134,
-0.00011569133,
0.0017162593,
0.01294099,
0.00402762,
0.011231306,
0.014111466,
-0.00425777,
-0.027959902,
-0.03855994,
-0.011007732,
0.0011178701,
0.026315976,
0.018596098,
0.0060595134,
0.00018751038,
0.022554671,
0.0042939363,
0.0131251095,
-0.021081714,
0.021949707,
-0.0223574,
-0.006878189,
0.0039059694,
0.0086470535,
-0.009166534,
0.01289496,
0.028091418,
-0.0060299225,
-0.0006846954,
-0.019687664,
0.0004726289,
-0.012625356,
0.0028801593,
0.023422666,
0.04079568,
0.0279336,
-0.013164564,
0.009271746,
-0.0007759333,
0.015610727,
-0.0014795339,
-0.016452417,
0.024553686,
-0.0027042592,
0.017057382,
0.0026763123,
-0.007187247,
0.017333562,
0.010626341,
-0.0005992112,
-0.0020927184,
-0.001902023,
0.007272731,
0.0140194055,
0.00093210634,
0.01582115,
0.013651166,
0.005388791,
0.003067567,
-0.0020680595,
-0.02617131,
0.022515219,
-0.039349027,
-0.015203033,
-0.008403753,
-0.0015140563,
0.02318594,
-0.003468685,
0.012421509,
0.009968771,
-0.01154694,
0.005753743,
-0.03550881,
0.011001157,
-0.0017540696,
-0.020489901,
-0.015321395,
0.0041558463,
-0.02151571,
-0.029459164,
-0.016176237,
0.023711996,
-0.027486451,
-0.018241009,
0.021449953,
0.015281941,
0.017175745,
0.03053758,
0.0021140894,
-0.0065691303,
0.034588214,
0.01825416,
-0.0136774685,
0.0032040128,
-0.024422172,
0.0028752275,
-0.01704423,
0.015426607,
-0.010008225,
-0.022304796,
0.013940497,
0.0053559127,
-0.0070886114,
0.000051090155,
0.008088118,
-0.015203033,
0.018596098,
0.011520637,
0.012625356,
-0.023856662,
-0.005484139,
-0.0039914534,
-0.031615995,
-0.015913209,
-0.0064639193,
-0.014072011,
-0.021357894,
0.0025875403,
0.00973862,
-0.030484974,
-0.0118165435,
0.019122154,
-0.030695396,
0.020410992,
0.014256131,
0.0038369244,
0.011619273,
-0.012224237,
0.02607925,
0.008929809,
-0.0011573243,
-0.0013447319,
-0.00339964,
0.024987683,
0.0061877393,
-0.015347698,
-0.0008490881,
-0.012197935,
-0.011441729,
-0.004843008,
0.004455041,
-0.019319424,
0.015978966,
-0.008219632,
-0.024172297,
-0.014216676,
-0.01145488,
-0.010744704,
0.0025020563,
0.012046694,
-0.040585257,
-0.019727118,
0.020134812,
0.016163087,
-0.014427099,
0.026934093,
-0.027617967,
-0.01899064,
0.03669244,
0.003958575,
-0.00572744,
-0.0162946,
0.030116735,
-0.012553023,
-0.0316423,
-0.0058030607,
-0.0067664017,
0.0052178227,
-0.006062801,
0.037481524,
0.008068391,
0.03611378,
0.00036865054,
0.011553516,
0.0023146486,
-0.0014869316,
0.0042643454,
-0.014506008,
0.015216184,
0.0077133034,
0.0123426,
0.0014910414,
-0.01536085,
0.005129051,
-0.018280463,
-0.0013406221,
0.012677961,
-0.007608092,
0.001319251,
0.024461627,
-0.05129051,
-0.048107866,
0.0063817226,
-0.032273564,
0.004556964,
-0.029695889,
-0.011461455,
0.028091418,
0.0065494035,
0.019332577,
-0.017833315,
0.015637029,
0.005303307,
-0.007627819,
0.006710508,
0.0018247585,
-0.025211258,
-0.0046161455,
-0.011980937,
-0.011323366,
-0.016846959,
0.018885428,
0.015558121,
0.014558613,
-0.017557135,
-0.0033733372,
0.012816051,
-0.03574554,
-0.0061680125,
-0.008745689,
-0.04805526,
0.003715274,
-0.0018954473,
-0.007272731,
-0.025198106,
0.010863067,
0.00058236095,
0.0030396201,
0.011573243,
-0.0054019424,
-0.015203033,
0.01964821,
-0.005214535,
0.011369396,
-0.019845482,
0.024711505,
0.018017435,
-0.01825416,
-0.04300512,
-0.015610727,
0.0066414634,
-0.009620258,
0.018951185,
0.029353952,
-0.01974027,
-0.014190374,
0.016465569,
0.017833315,
0.0012058201,
-0.0055827745,
0.008226208,
-0.005306595,
-0.006805856,
-0.01658393,
-0.035429906,
-0.02309388,
0.02690779,
0.0022028615,
-0.014295585,
-0.01758344,
-0.010876218,
-0.0040769377,
0.00006082528,
-0.00537564,
0.0037448646,
0.010869643,
-0.0022045055,
-0.0033700494,
-0.007982907,
0.0071017626,
0.006296239,
-0.018030586,
0.024185447,
-0.000693326,
-0.013302653,
0.0031283922,
-0.0032730578,
-0.0056123654,
-0.005862242,
-0.0064113135,
0.04247906,
-0.009521622,
-0.0023014972,
0.010994581,
-0.0020483325,
0.028564867,
0.0077790604,
0.008995566,
-0.020529354,
-0.040743075,
0.0070820353,
0.02208122,
0.010192345,
-0.00621733,
-0.0045766914,
-0.021094866,
-0.01387474,
-0.018951185,
-0.034404095,
0.007877696,
-0.049764942,
-0.000101666585,
0.008673357,
0.019095851,
0.012993596,
0.0068979156,
-0.0069242185,
-0.013151412,
0.0372448,
-0.025737314,
0.0020203858,
0.00196778,
-0.011448304,
-0.0080289375,
0.015610727,
0.011448304,
-0.045582794,
-0.0028094705,
-0.01574224,
-0.02243631,
-0.04952822,
-0.0014836437,
0.014558613,
0.0113365175,
-0.023909267,
0.00060660887,
0.011974361,
0.017557135,
-0.009488744,
-0.026473792,
0.030327156,
-0.030511277,
0.01759659,
0.011106368,
-0.004967946,
0.0038204852,
-0.008686508,
-0.0059247115,
0.017373016,
-0.0052704285,
-0.02756536,
-0.015610727,
0.027460149,
-0.009422987,
0.02494823,
-0.035272088,
-0.0023179364,
-0.0086470535,
-0.008502388,
0.0018806519,
-0.0022258766,
-0.010994581,
-0.003715274,
0.009422987,
0.002640146,
-0.026565854,
-0.011803392,
0.012553023,
-0.023961874,
-0.04487262,
-0.01778071,
-0.013545955,
0.02494823,
0.02764427,
0.0016389948,
-0.030379763,
-0.009732045,
-0.042268638,
-0.027144516,
-0.0005342761,
0.029538073,
-0.012211086,
0.015781695,
-0.022396855,
0.016715445,
-0.0060134833,
0.01778071,
-0.014387645,
-0.035614025,
0.028275536,
-0.016597083,
0.021278985,
0.02131844,
-0.010810461,
0.0027141226,
0.010310708,
0.015913209,
-0.03556142,
0.022673035,
-0.025263863,
0.019358879,
-0.023343757,
0.012973868,
-0.014203525,
0.013545955,
-0.004734508,
0.0010159466,
0.00048249244,
-0.0035706083,
-0.009883286,
-0.003000166,
0.021581467,
0.0089232335,
0.012243965,
0.012947566,
-0.010724977,
-0.03137927,
0.0045142225,
0.010422494,
-0.0020220296,
0.028643776,
0.026749972,
0.038586244,
-0.011224731,
0.0041065286,
0.00326977,
-0.0062502087,
-0.009179686,
-0.019201063,
0.010120012,
-0.018675005,
-0.01630775,
0.013532803,
-0.013901043,
0.0019496969,
0.006490222,
0.0040078927,
-0.031247756,
-0.017991131,
0.021752436,
0.009304624,
-0.012816051,
-0.0034062157,
0.0162946,
-0.023317454,
-0.010185769,
-0.030695396,
0.009113928,
-0.034219977,
0.007555486,
-0.023225395,
0.016281448,
0.008693083,
0.022751944,
-0.0006419533,
0.0028916667,
-0.008384026,
0.20800273,
-0.014966307,
-0.003965151,
0.0066842055,
0.02085814,
0.019332577,
0.02169983,
-0.00031871625,
-0.010271253,
0.0151241245,
0.018596098,
-0.0039289845,
-0.016715445,
0.00029159148,
0.019858632,
-0.009804378,
-0.027670572,
-0.032641806,
-0.009199413,
0.0043925717,
-0.003156339,
0.008088118,
0.0158343,
0.0040604984,
0.01574224,
-0.0100148,
-0.013276351,
0.0070360056,
0.01229657,
0.0090613235,
-0.017346714,
0.014874247,
-0.00086470536,
0.013545955,
-0.0011556804,
0.0093375025,
0.00407365,
-0.00442545,
0.0053920792,
0.014045709,
0.0052671405,
-0.007772485,
-0.0025875403,
-0.004251194,
0.026052948,
0.031168846,
-0.0044714804,
-0.004432026,
0.0028061827,
-0.013223745,
-0.037534133,
0.016978472,
0.0076212436,
0.0158343,
-0.01405886,
-0.01038304,
0.027433846,
-0.017491378,
-0.000021345359,
0.03782346,
-0.013901043,
0.002035181,
-0.003846788,
0.022515219,
-0.013171139,
0.011251033,
-0.022949215,
0.018135797,
0.025132349,
-0.014374494,
0.011106368,
-0.011172125,
-0.0061877393,
0.008666781,
-0.01168503,
-0.025711011,
0.048002657,
0.012224237,
-0.0010093709,
0.0016233774,
0.012723992,
0.009521622,
-0.019674513,
-0.020082207,
-0.009462441,
-0.015203033,
0.0061647245,
0.009837257,
-0.008482661,
-0.023448968,
0.0014967951,
-0.008949536,
-0.008798295,
0.0004816705,
0.011790241,
0.0065329643,
0.0017474939,
0.01611048,
0.0025365786,
-0.0049317796,
-0.028328141,
0.047871143,
-0.003133324,
0.02617131,
0.0077264546,
0.02142365,
-0.015623878,
0.024843019,
-0.007384518,
0.002416572,
0.03266811,
-0.028827896,
0.016689142,
-0.016149934,
-0.0008314158,
0.023278,
0.011112943,
-0.02998522,
0.029932614,
-0.025171803,
-0.009843832,
-0.026052948,
-0.0017080397,
0.026421187,
-0.02298867,
-0.00000646975,
-0.0052013835,
-0.0096794395,
0.0035738964,
-0.009718894,
-0.016005268,
-0.006332405,
-0.0025924721,
0.017754406,
0.005993756,
-0.02355418,
0.00903502,
-0.01704423,
-0.027065607,
-0.007364791,
0.00568141,
-0.001255138,
-0.012447812,
0.016347205,
-0.0025826085,
-0.013690621,
0.016005268,
0.0022456036,
0.009712318,
-0.0113365175,
-0.022041768,
-0.0344567,
-0.011191851,
0.004520798,
0.025382226,
-0.017359864,
-0.016123632,
-0.004369557,
0.0026204188,
0.023488423,
-0.009995073,
-0.0014598068,
0.017202048,
-0.000117848984,
-0.008186754,
0.00488575,
-0.16528694,
0.0022340962,
0.030511277,
-0.03640311,
0.015886907,
0.0021831344,
0.010185769,
-0.025934584,
0.007627819,
0.008818022,
0.018648703,
0.0050041126,
-0.027617967,
-0.009850408,
0.0037974704,
0.0039552874,
-0.0060266345,
0.042189732,
0.03435149,
0.011980937,
0.00987671,
-0.009784651,
0.006865037,
-0.01042907,
-0.007884271,
-0.013243472,
-0.009850408,
-0.015913209,
-0.02047675,
-0.00949532,
-0.011139247,
0.016649688,
0.017570287,
-0.00875884,
0.0034423822,
0.030590186,
-0.0033897765,
-0.018951185,
-0.0103698885,
-0.0010685523,
0.017728103,
0.059917834,
0.021923404,
-0.011862574,
-0.012743719,
0.035535116,
0.023212243,
-0.0059477263,
0.036166385,
-0.0075752134,
0.04776593,
-0.027670572,
0.024382718,
-0.001030742,
0.009067899,
0.013250048,
0.017820165,
0.007476578,
0.004405723,
-0.0063455566,
0.00042618797,
-0.04200561,
-0.0014926853,
-0.0020861428,
-0.015374001,
-0.046713818,
-0.044083536,
0.005780046,
-0.024619443,
-0.0061877393,
-0.029564375,
-0.018411977,
0.03285223,
-0.007963181,
0.024882471,
0.0022669747,
0.002054908,
0.0058819694,
0.009843832,
0.0070097027,
0.0063455566,
0.014532311,
0.0011088285,
-0.0011992444,
-0.0035081392,
0.0015625522,
0.01722835,
0.013822135,
-0.024159145,
-0.01499261,
0.031615995,
0.0014581628,
0.0008860764,
-0.0003197437,
0.015032064,
0.017346714,
0.0029196136,
-0.017451923,
-0.011257609,
-0.028196627,
0.009252018,
-0.029538073,
-0.023606785,
-0.005125763,
0.03500906,
-0.014926853,
0.00027946752,
0.01359856,
0.051237904,
-0.014755884,
-0.017714953,
0.00039022707,
0.0009378601,
0.025171803,
-0.0107841585,
0.029538073,
-0.019766573,
0.008679932,
-0.009120504,
-0.032931138,
0.05058033,
-0.006108831,
0.025395377,
0.024172297,
0.0200296,
-0.0103698885,
-0.1089989,
-0.018701307,
0.015229335,
0.03137927,
-0.013368411,
0.01667599,
-0.0018477734,
0.021765588,
-0.017004777,
0.046240367,
-0.023356909,
-0.011875725,
-0.017096836,
-0.0009962195,
-0.003892818,
-0.007489729,
0.007095187,
-0.02039784,
-0.00889693,
0.01778071,
-0.005033703,
-0.010468524,
-0.00082073035,
-0.011803392,
0.004810129,
-0.0022258766,
-0.03287853,
0.01814895,
0.030327156,
0.021647224,
0.0020713476,
-0.020779232,
0.029353952,
-0.016360357,
-0.028012509,
-0.020726625,
-0.004188725,
-0.043820504,
0.039349027,
-0.01741247,
0.017622892,
0.020358386,
-0.0031826417,
-0.0034785485,
0.017570287,
0.013177715,
-0.024843019,
0.011527213,
0.0005540032,
-0.0146375215,
-0.011698181,
-0.0055367444,
-0.00523755,
-0.012138753,
0.012165057,
-0.026657913,
0.027039304,
0.026421187,
-0.022844004,
-0.01499261,
0.017017927,
0.008081543,
-0.0017310546,
-0.010126588,
0.009107353,
-0.012888384,
-0.00879172,
-0.030143037,
0.02672367,
-0.015071519,
-0.0035936234,
0.0029459163,
0.002977151,
-0.016452417,
0.002436299,
-0.014427099,
-0.005326322,
-0.0140194055,
0.012349176,
-0.030143037,
-0.002354103,
-0.017714953,
0.017741255,
-0.026868336,
0.032536592,
0.0006735989,
0.0020664157,
-0.006431041,
0.0040900894,
-0.00828539,
0.0177018,
0.027696874,
-0.022830851,
-0.0074371235,
-0.020792384,
0.010968278,
-0.015216184,
0.0021354605,
-0.002395201,
0.027249726,
0.0065494035,
-0.033851735,
-0.063547626,
-0.005457836,
0.0043498296,
0.016347205,
-0.0039026816,
-0.02010851,
0.025592647,
-0.0049975365,
0.016057875,
0.0058392272,
-0.0008614175,
0.02430381,
-0.016136782,
0.009284897,
-0.015781695,
-0.004050635,
0.033536103,
0.012382055,
0.01750453,
0.025842525,
0.021818193,
-0.01601842,
-0.018451432,
0.013388137,
-0.0014121329,
0.00102992,
-0.00021186103,
0.022252189,
-0.009554501,
-0.015045215,
0.013861588,
-0.009666288,
-0.0114746075,
-0.016491871,
-0.0059904684,
-0.027880995,
0.01574224,
-0.0014145988,
0.0279336,
0.027433846,
0.0007360681,
-0.033772826,
0.024356415,
0.034877546,
-0.014795339,
0.010139739,
-0.022133827,
0.00092964043,
0.026210764,
-0.005510442,
0.03948054,
-0.011809968,
-0.0013118534,
-0.027170818,
-0.03461452,
-0.007226701,
-0.0027239863,
-0.0041953004,
-0.02531647,
0.0005527703,
0.043978322,
0.021449953,
0.0041492707,
0.018793369,
0.010573735,
-0.015650181,
-0.01603157,
-0.0029903024,
-0.011783665,
-0.009291473,
-0.02104226,
-0.0070623085,
-0.0022653309,
0.0040144688,
0.00509946,
-0.006174588,
-0.013131686,
-0.010922248,
-0.0032401793,
0.018832823,
0.010126588,
0.01778071,
-0.012105875,
0.02169983,
0.022488914,
0.016820656,
-0.017807012,
0.01257275,
0.0307217,
0.002888379,
-0.014584917,
0.02421175,
0.010968278,
-0.009015293,
0.002794675,
0.005480851,
0.005152066,
0.0026434339,
0.009455865,
0.029511768,
0.0073516397,
0.01863555,
-0.007851393,
-0.02448793,
-0.0070162783,
0.015216184,
-0.023014972,
-0.032247264,
0.005796485,
-0.028328141,
0.00712149,
-0.021134319,
-0.007042581,
0.003044552,
-0.03158969,
-0.010593463,
0.00061482855,
-0.021634074,
-0.016636537,
0.029748494,
0.012204511,
0.007746182,
0.010586887,
0.0053920792,
-0.0020762791,
-0.0066414634,
0.02375145,
-0.010955126,
0.014006254,
-0.03611378,
0.010994581,
-0.008995566,
-0.027959902,
-0.013374986,
0.016768051,
-0.01758344,
0.028906804,
0.0120993,
-0.042873602,
0.09284897,
0.0147821875,
-0.04087459,
0.00621733,
-0.02505344,
0.025250712,
0.018385675,
-0.016728597,
-0.019056397,
-0.026960395,
0.0130593525,
-0.027144516,
0.010277829,
-0.034404095,
-0.04629297,
0.010185769,
0.018359372,
0.0209502,
-0.00898899,
-0.014269282,
0.02719712,
-0.028643776,
0.000028203614,
0.022949215,
-0.009107353,
0.01658393,
0.023278,
-0.0033733372,
-0.007049157,
-0.015531818,
0.0048627346,
-0.017070534,
-0.03332568,
-0.014269282,
0.008601024,
0.004057211,
-0.0012181496,
-0.025408529,
0.03606117,
0.02384351,
0.01131679,
0.020976502,
-0.02486932,
0.005155354,
-0.0019480529,
-0.028854199,
-0.020147964,
-0.010027952,
0.017688649
] |
The incidence of sepsis is increasing over time, along with an increased risk of dying from the condition. Sepsis care costs billions annually in the United States. Death from sepsis is understood to be a complex process, driven by a lack of normal immune homeostatic functions and excessive production of proinflammatory cytokines, which leads to multi-organ failure. The Toll-like receptor (TLR) family, one of whose members was initially discovered in Drosophila, performs an important role in the recognition of microbial pathogens. These pattern recognition receptors (PRRs), upon sensing invading microorganisms, activate intracellular signal | [
-0.008513588,
-0.0023804442,
-0.014312318,
-0.02399883,
-0.0041941945,
0.02057231,
-0.0026835597,
0.009963271,
-0.01686903,
-0.007801926,
-0.0024282178,
0.010767186,
0.0063225916,
0.013824698,
0.005591161,
0.0008245068,
0.04283152,
0.01465497,
0.010384996,
0.00824342,
-0.01797606,
-0.014259602,
-0.0016267742,
0.0026522595,
0.001653132,
0.0052616876,
0.000023565059,
-0.036901005,
-0.010497018,
-0.015182127,
-0.016460484,
-0.024908178,
-0.036004838,
0.000046460875,
-0.0030295064,
-0.0015279321,
0.017211683,
-0.006958475,
-0.0019504816,
-0.025303544,
0.024934536,
0.009627208,
0.01661863,
-0.015854253,
-0.0167636,
-0.0140619185,
0.0057361294,
-0.020045152,
-0.019148985,
0.0072747692,
0.021402583,
-0.008612431,
-0.038324326,
-0.009897376,
-0.020045152,
-0.019162163,
0.0081116315,
0.0037098688,
0.02894093,
-0.027438533,
0.0070902645,
-0.0058053187,
-0.02228557,
0.013468866,
0.0022074708,
0.008658557,
-0.008058916,
0.028624635,
-0.004494015,
0.017686123,
0.038640622,
0.04074925,
0.0010452538,
0.005640582,
0.018147387,
-0.022628222,
-0.019412564,
0.005607635,
-0.008994619,
0.018305533,
0.018318713,
-0.016460484,
-0.011070301,
0.020994036,
0.016315514,
-0.030601475,
0.008408157,
0.014154171,
0.013851055,
-0.0051134247,
0.0035484268,
0.011913752,
-0.0015748821,
0.037981674,
0.0003926909,
0.009343862,
0.009429525,
0.036426563,
0.008012789,
-0.05218856,
-0.003584669,
-0.0041184155,
-0.012500215,
-0.012816509,
-0.027754826,
0.006266581,
-0.007439506,
-0.010233439,
0.021112645,
0.008566304,
-0.029995244,
0.042726092,
-0.005900866,
-0.016948104,
0.041065544,
-0.002523765,
0.02141576,
0.024446914,
-0.022707297,
-0.022496434,
0.028861856,
0.0010938512,
0.013205288,
0.0019060028,
0.029020004,
0.0014546243,
-0.00634236,
0.0067410227,
0.0009661803,
-0.008157757,
-0.013356846,
0.02265458,
-0.0026654385,
-0.00073966745,
-0.008645378,
0.011465669,
-0.02266776,
0.0061644446,
-0.0081314,
-0.0049091512,
0.00898144,
0.017791554,
-0.027174953,
-0.0075185793,
0.029336298,
0.019148985,
0.035530396,
0.018397786,
-0.0030805748,
0.029072719,
0.007854642,
-0.0238934,
-0.009633798,
-0.024301946,
0.0042600892,
0.010543144,
-0.006905759,
0.03323726,
-0.0073999693,
-0.012711078,
-0.0056241085,
-0.008098452,
0.0018219871,
0.0027824016,
0.019979257,
0.01921488,
0.015590674,
0.040222093,
0.0042139627,
0.008935315,
-0.010497018,
0.015458885,
0.011043943,
0.024960892,
0.005208972,
0.00609855,
-0.016038757,
0.010088471,
-0.009719461,
-0.023932936,
-0.016776778,
0.03350084,
0.027227668,
0.017422546,
-0.013192109,
-0.006477444,
0.038482476,
0.0019603658,
0.012236636,
0.0010131302,
0.010866027,
-0.00071495696,
-0.00317118,
-0.024104262,
-0.64481866,
-0.024209695,
0.0153666325,
0.021020394,
-0.02154755,
0.010813312,
0.005983234,
-0.0022470076,
-0.020835888,
0.034581512,
-0.004480836,
0.006685012,
-0.010859438,
-0.0167636,
-0.010391586,
-0.020387804,
-0.015472064,
-0.028150193,
0.011406364,
0.0051694354,
0.0015419348,
0.0056438767,
-0.0027181543,
0.004286447,
-0.028624635,
0.014088276,
0.015696105,
-0.008105041,
-0.0076437793,
0.024908178,
-0.01564339,
0.007736032,
0.0096601555,
0.00898803,
0.05883074,
-0.0013211877,
-0.006800328,
0.027596679,
0.019662963,
0.045968108,
-0.011386596,
-0.0019109448,
0.030575117,
-0.010174134,
-0.011142785,
0.0066158227,
0.0045236675,
0.016921746,
-0.005037646,
-0.008282958,
0.010641986,
0.019056732,
-0.0010625512,
0.0021877023,
0.020216478,
-0.00010759361,
0.013132803,
-0.021771591,
0.007920537,
0.0028433541,
-0.012928531,
0.008803525,
0.00055557425,
-0.015182127,
-0.023208095,
0.016249621,
-0.030970486,
-0.014720865,
0.02191656,
-0.025277188,
0.010088471,
0.031708505,
0.0019653079,
-0.005096951,
0.0033540376,
0.029784381,
0.0033705113,
0.021244435,
-0.013561118,
0.0060128868,
0.00027675752,
-0.0021267498,
-0.031181348,
0.009146177,
0.020704098,
0.000042728563,
0.0054626665,
0.006971654,
-0.001858229,
-0.002505644,
-0.0018796448,
-0.011360237,
-0.029995244,
-0.02057231,
-0.0066454755,
0.019254416,
0.0056570554,
-0.020519594,
0.0061018444,
-0.016407767,
-0.008836472,
-0.022997232,
0.018700901,
0.0044643623,
0.033922564,
0.0010419592,
-0.03128678,
0.0002823174,
0.044623856,
-0.0011457432,
0.006526865,
-0.017896987,
0.00923184,
-0.0062105707,
0.015537959,
-0.011307522,
0.0069518853,
0.023577105,
0.009594261,
-0.03729637,
0.020769993,
0.010655165,
0.026015207,
-0.0024578704,
0.016183726,
0.002869712,
-0.011610637,
-0.0022190022,
0.021771591,
-0.02080953,
0.0053407615,
-0.031840295,
0.011103248,
-0.013277772,
0.007986431,
-0.0005341585,
0.0241438,
0.013402971,
0.028255625,
-0.042989668,
-0.005021172,
-0.02994253,
0.019649785,
0.00045508493,
-0.007452685,
0.0039602686,
0.0027247437,
-0.009864429,
0.016065115,
-0.013508403,
0.015946506,
0.00020520005,
0.000024478832,
-0.010121418,
-0.009508598,
0.005739424,
-0.01871408,
-0.0029108962,
-0.02401201,
-0.016341873,
0.0057064765,
0.00026625558,
-0.024038369,
0.005330877,
-0.021494834,
-0.021956097,
0.022246033,
0.0115711,
0.0029520802,
-0.031787578,
0.000665536,
-0.0117819635,
-0.010635396,
0.002411744,
0.01711943,
0.012467268,
-0.0018812922,
-0.0070902645,
0.0050672987,
-0.0076569584,
0.008836472,
-0.02684548,
-0.0051430776,
0.027886616,
0.011959879,
0.0025138808,
0.031576715,
-0.002784049,
0.030759621,
0.039826725,
-0.0032832008,
0.009436114,
-0.02547487,
0.027754826,
0.0024974071,
-0.026015207,
0.0083554415,
-0.00036283242,
-0.024315126,
0.0104772495,
0.004569794,
-0.025567124,
0.008632199,
-0.0310232,
-0.014681328,
-0.008915546,
0.006685012,
-0.019412564,
0.02994253,
0.0055944556,
-0.003693395,
0.004322689,
0.014075097,
-0.020835888,
0.0037592896,
0.02672687,
0.02243054,
-0.0124475,
0.004642278,
-0.011004406,
-0.017396187,
-0.020967677,
0.026687333,
-0.016196905,
-0.0076899054,
0.011630406,
0.02007151,
-0.0045170784,
-0.005317698,
-0.001718203,
-0.024670957,
0.00025904833,
0.01934667,
0.020901782,
0.00837521,
0.02376161,
-0.013508403,
0.0005143901,
0.02954716,
-0.0052155615,
-0.0065795807,
-0.0037494055,
0.005986529,
-0.004085468,
-0.018740438,
-0.0013137746,
0.031102274,
-0.0014768639,
-0.02844013,
0.008836472,
0.0039734473,
-0.0065400437,
-0.030680548,
-0.005390182,
0.0021959392,
-0.013930129,
0.013837877,
-0.0025896598,
0.05050166,
-0.00329638,
0.02695091,
-0.014931727,
0.013930129,
-0.016025579,
0.012585878,
0.011472259,
-0.00985784,
-0.014786759,
0.0008475699,
-0.005607635,
-0.037665382,
0.0065828753,
0.0037724688,
-0.02131033,
-0.0068332753,
0.035266817,
0.01983429,
-0.012137794,
-0.0039734473,
-0.0020707394,
0.00677397,
-0.018397786,
0.018793155,
0.02695091,
-0.017765198,
-0.05245214,
-0.018793155,
-0.0041843103,
0.008678325,
0.022984054,
0.008408157,
0.007314306,
-0.0077030845,
-0.0015839427,
0.0068530436,
0.015076696,
0.01872726,
-0.03168215,
0.009245019,
0.013337077,
0.0067080753,
0.0011951642,
-0.017158967,
-0.022259213,
0.015630212,
-0.0044511836,
-0.009600851,
-0.01958389,
-0.019307133,
-0.013574298,
0.0026802649,
-0.02033509,
-0.0043160995,
-0.020941319,
0.028123837,
0.0030904592,
-0.007044138,
0.011893984,
0.014839475,
-0.0073538427,
-0.0070309592,
-0.02684548,
0.015248022,
-0.009752408,
0.032551955,
0.02229875,
0.0085992515,
0.03473966,
0.0054857293,
-0.009963271,
-0.023880221,
-0.015142591,
0.02042734,
0.001068317,
-0.010332281,
0.0053407615,
0.014760401,
0.0022931339,
0.008586072,
0.013706087,
0.019676141,
-0.015261201,
-0.012829688,
0.00689258,
0.0231422,
-0.015920147,
0.035135027,
0.033316333,
0.025316725,
-0.020295551,
-0.010529965,
0.028545562,
-0.014615433,
-0.008500409,
-0.018450502,
0.014813117,
-0.01675042,
0.00079197134,
-0.009462472,
-0.0010320749,
-0.0040657,
0.008836472,
0.0011926931,
0.007920537,
0.012895583,
0.0010905565,
0.0056834137,
-0.0036802161,
-0.007538348,
-0.013416151,
0.00035418375,
0.0128362775,
0.008579483,
-0.013238235,
0.042936955,
0.004012984,
-0.0060194763,
-0.03777081,
0.02055913,
-0.0065433388,
0.009337272,
-0.009198893,
-0.025408976,
-0.009245019,
0.0032140114,
-0.029389013,
0.012342067,
-0.0027741648,
-0.0076042423,
0.011808321,
-0.00209545,
-0.010852849,
-0.04038024,
-0.0062764655,
0.02105993,
-0.029072719,
-0.012487036,
0.005492319,
0.0042600892,
-0.001255293,
-0.0094163455,
-0.003531953,
0.038377043,
0.016144188,
0.0010444302,
0.0060524237,
0.005258393,
-0.042067144,
0.021494834,
-0.0012412905,
0.012645183,
-0.033685345,
-0.0037131635,
0.009073693,
0.00529793,
0.0017017293,
0.0026868542,
0.023801148,
-0.0013870824,
0.020282373,
0.020269195,
0.026937732,
-0.023498032,
-0.014575897,
-0.0011893985,
-0.012645183,
-0.034528796,
0.0033705113,
0.016724061,
-0.034528796,
0.010075292,
-0.0062171603,
0.005344056,
-0.0070704957,
0.030733265,
-0.007432916,
0.003332622,
0.002474344,
0.013060319,
0.0108001325,
0.008770578,
0.02560666,
0.024222873,
-0.018200101,
-0.024446914,
0.013231645,
0.020625025,
0.024776388,
0.002788991,
-0.0019438921,
0.0008047384,
-0.009310914,
-0.03769174,
-0.033184547,
-0.014365033,
0.02229875,
0.0096601555,
-0.018990837,
-0.027754826,
0.0064708544,
-0.007195696,
-0.00025431215,
0.0076437793,
-0.028993646,
-0.027596679,
-0.0039965105,
-0.007327485,
-0.022694116,
0.034397006,
-0.027807541,
-0.0055219717,
-0.0024974071,
0.0004460244,
0.0125924675,
-0.020176942,
-0.014707685,
-0.036004838,
0.008144579,
-0.0112877535,
-0.053611886,
-0.01318552,
-0.010266386,
0.040907398,
0.026542366,
0.0010081881,
-0.014628612,
0.027438533,
0.021758413,
0.001884587,
0.0015394638,
-0.011926931,
0.008282958,
-0.0012940061,
0.009139588,
0.0136533715,
-0.00012705312,
-0.010292744,
0.0030673959,
0.014641791,
-0.0006778912,
0.0011473906,
-0.021890203,
-0.029758023,
-0.035029594,
-0.02685866,
0.029362656,
-0.013600656,
0.011656763,
-0.025211293,
0.0065696966,
0.02587024,
-0.0018417555,
-0.0027692227,
0.0042798575,
0.02857192,
-0.020598667,
0.0325256,
-0.003657153,
0.016921746,
-0.01280333,
-0.013561118,
-0.0079468945,
0.003423227,
-0.00054239534,
0.008810115,
0.006022771,
0.020453699,
0.012737435,
0.0007223701,
0.023946116,
-0.020111047,
-0.03350084,
0.0066916016,
-0.0121839205,
-0.031102274,
0.00541654,
-0.003337564,
-0.01971568,
-0.010424534,
-0.011610637,
-0.0076899054,
0.016420947,
-0.030311538,
-0.020783173,
0.0052518034,
-0.009521777,
0.0037757633,
-0.015946506,
0.016196905,
0.003953679,
-0.006487328,
-0.018990837,
-0.0035484268,
0.0061018444,
0.0022947812,
0.034027997,
0.02904636,
-0.033896208,
-0.03065419,
0.0071363905,
0.0112086795,
-0.029494446,
-0.025461692,
0.0018203397,
0.00081750547,
-0.0006416491,
-0.022970874,
-0.0052386248,
-0.014734044,
0.0055582137,
-0.02131033,
-0.011755605,
0.012375015,
-0.010813312,
-0.000032020682,
0.011149375,
-0.033079114,
0.011749016,
-0.00046167438,
-0.0104706595,
0.0011902221,
-0.031629432,
0.0124475,
-0.024710493,
0.003782353,
0.022601865,
-0.004701583,
0.042014427,
0.015406169,
0.008539947,
0.016091473,
0.0025468282,
-0.022114243,
0.042304363,
0.0026011912,
0.00020653853,
0.0016811372,
-0.00012056661,
-0.014839475,
-0.01908309,
0.005294635,
-0.0018862344,
-0.025540765,
-0.002050971,
-0.0016951398,
0.015564316,
-0.005320993,
0.015590674,
-0.039510433,
-0.009772177,
-0.012579288,
-0.024723673,
0.014865832,
-0.009139588,
-0.0034561744,
-0.00240186,
-0.0121905105,
0.01613101,
0.019781573,
0.008394978,
-0.016829493,
0.024552347,
-0.026937732,
0.014879012,
-0.006128202,
-0.016104652,
-0.014075097,
0.011973058,
-0.014154171,
-0.034265216,
0.015129412,
-0.013482045,
-0.03605755,
-0.005713066,
0.0019109448,
0.013211877,
0.018173745,
-0.0038251844,
0.02253597,
0.0016844319,
0.004691699,
-0.0043259836,
-0.006072192,
0.04283152,
-0.009548135,
0.00046661648,
0.02672687,
-0.016038757,
0.0053012245,
0.02082271,
0.018740438,
0.0021399288,
0.011096659,
-0.021745235,
-0.0074790427,
0.0063851913,
-0.0118610365,
0.0025748333,
-0.017923344,
-0.00935704,
-0.018015597,
0.007083675,
0.011979647,
-0.022338286,
-0.02401201,
-0.025843881,
-0.004075584,
0.004480836,
0.011867627,
-0.0017890397,
0.0034495848,
-0.0055186767,
-0.018753618,
-0.009805123,
-0.034555156,
0.033896208,
-0.003792237,
-0.007413148,
-0.011933521,
0.008579483,
-0.035662185,
-0.010615628,
0.0028911277,
0.0149580855,
0.018700901,
0.025316725,
-0.0025171756,
0.022483254,
-0.010602449,
0.0115315635,
-0.014668149,
-0.030364254,
0.004029458,
-0.008269778,
0.027860258,
0.0028977173,
-0.03128678,
-0.030522402,
0.055087928,
-0.008559715,
-0.001754445,
0.026674153,
-0.014944906,
0.0031991852,
-0.005759192,
-0.004187605,
-0.03547768,
0.008796936,
0.02944173,
-0.010444302,
0.0051892037,
0.0044643623,
-0.0010666696,
-0.020704098,
0.0075515267,
0.022101065,
0.01648684,
-0.00031773577,
-0.012388194,
-0.026252428,
0.014391392,
-0.009488829,
0.031313136,
0.0121971,
-0.0062731705,
0.0040426366,
-0.0040426366,
-0.0063950755,
-0.017910166,
-0.020361446,
-0.0100687025,
0.007696495,
-0.004793836,
-0.0046587517,
-0.025580302,
-0.00071248587,
0.00015979452,
-0.011623816,
-0.0039668577,
-0.024209695,
-0.0016630162,
-0.036558352,
0.0072945375,
0.0115711,
-0.015432526,
0.002599544,
-0.0028417069,
-0.025540765,
-0.029389013,
0.0012091668,
0.0047510043,
0.006859633,
0.0060952553,
-0.011465669,
0.0032980272,
-0.006401665,
-0.009020978,
0.005271572,
-0.027227668,
0.018345071,
0.19431014,
-0.022101065,
-0.0044281203,
0.0060787816,
0.0005333348,
0.0054494874,
-0.023867043,
-0.024710493,
-0.015762,
-0.004935509,
0.020506416,
-0.003719753,
-0.0010798486,
0.0004447889,
0.0057163606,
-0.016644988,
-0.016051937,
-0.016065115,
-0.014430928,
-0.003584669,
0.016302336,
-0.005446193,
-0.008579483,
-0.011920342,
0.06478762,
0.012625415,
-0.0057558976,
0.0090077985,
0.02337942,
-0.020862246,
-0.019386206,
0.009871018,
-0.0036176161,
0.018608648,
0.0012907115,
-0.0030888116,
0.0070111905,
-0.006885991,
0.01971568,
0.008309315,
0.009277967,
0.018582292,
0.013930129,
-0.0055120876,
0.003657153,
0.022101065,
-0.0009966566,
-0.018292354,
-0.0036044372,
0.0072220536,
-0.029230867,
-0.00074172666,
-0.0043655206,
0.0022667758,
0.012381605,
0.0029965593,
0.014048739,
0.010319102,
-0.00923184,
0.0034429955,
-0.006138087,
-0.00029693777,
-0.031576715,
0.017053535,
-0.01650002,
0.045730885,
-0.024446914,
0.035293173,
0.00094805926,
-0.013837877,
-0.0050837724,
-0.0051892037,
-0.017435724,
-0.0054033613,
-0.014931727,
0.0081116315,
0.024170157,
-0.004474247,
0.01613101,
0.01833189,
-0.001835166,
-0.0072352323,
-0.032920968,
0.008790346,
0.0010567855,
-0.03729637,
0.028888214,
0.0025369439,
-0.044123057,
0.015959684,
0.004813604,
0.013561118,
-0.012038953,
-0.0121048475,
0.019069912,
-0.014220065,
0.024222873,
0.001151509,
0.001723145,
-0.030390613,
-0.022470076,
0.072220534,
0.010582681,
0.009330682,
-0.023590283,
0.013877413,
-0.0007940305,
0.01022026,
0.027675753,
-0.019109448,
-0.0035385427,
-0.0032700219,
0.022865443,
-0.021771591,
-0.0027626331,
0.023814326,
0.006184213,
0.0024710493,
0.0013145983,
-0.01465497,
-0.0057921396,
-0.017989239,
-0.003004796,
0.01391695,
-0.0068991696,
0.00016041228,
-0.016948104,
0.0049058567,
-0.0049025617,
-0.037744455,
-0.0051200143,
-0.009370219,
-0.006625707,
0.01428596,
0.006375307,
-0.022074707,
0.007841463,
-0.017989239,
-0.024381021,
0.031339496,
-0.011465669,
0.0042699734,
-0.008928725,
0.009403166,
-0.0019405974,
-0.010048934,
0.037876245,
0.03186665,
-0.035003237,
0.008105041,
-0.015234843,
-0.01787063,
-0.0054890243,
0.0029520802,
0.025540765,
-0.044123057,
-0.026753228,
-0.0028005226,
0.015854253,
-0.0012206984,
-0.018028775,
0.009956681,
0.014760401,
-0.006612528,
-0.0011778668,
0.004223847,
-0.16552736,
0.007821695,
-0.0010296039,
0.008928725,
0.02685866,
0.009060514,
-0.009047335,
0.02352439,
0.009343862,
0.011195501,
0.042805165,
-0.010240029,
-0.008671735,
-0.018371427,
-0.0023409075,
-0.012625415,
0.0028812436,
0.048366673,
0.024657778,
0.019465279,
0.047444146,
-0.012566109,
-0.00751199,
-0.0123486575,
0.012994424,
0.013600656,
0.015472064,
-0.008684915,
-0.0012388194,
-0.02994253,
-0.037138224,
-0.006194097,
0.042146217,
0.003670332,
-0.01599922,
-0.009271377,
0.0074790427,
-0.019636605,
0.0065565174,
0.022984054,
0.042594302,
0.016341873,
0.0074922214,
0.0073538427,
-0.021389402,
0.016341873,
0.00048803224,
-0.0034759426,
0.024670957,
-0.015524779,
0.0012141089,
0.011004406,
-0.025988849,
0.027333101,
0.010075292,
0.011314111,
-0.011768784,
0.0006428847,
-0.007228643,
0.0021761707,
-0.0018368133,
-0.018318713,
0.02476321,
0.0080062,
0.009165945,
-0.013113035,
0.0012915351,
0.018674543,
-0.012605647,
0.012282763,
-0.020097869,
-0.016513199,
-0.00080432656,
-0.0108792065,
0.016315514,
0.01747526,
-0.0041579525,
-0.0050442354,
0.00075243454,
-0.006082076,
0.005614224,
0.0040821736,
-0.0074460953,
-0.018068314,
-0.021863844,
0.0007050728,
0.01846368,
0.015458885,
0.0032238958,
-0.030680548,
0.021718876,
-0.029389013,
0.013099857,
-0.009053925,
0.009706282,
0.029626234,
-0.017949702,
-0.00011171202,
-0.012546341,
0.008118221,
0.002469402,
-0.0017033766,
-0.014299138,
0.0033309746,
0.0031596485,
-0.005133193,
-0.032947324,
-0.015959684,
0.032578316,
-0.0117753735,
-0.007940305,
0.0007981489,
0.0124475,
0.011966468,
-0.007169338,
0.019254416,
0.014246423,
-0.0020394393,
-0.0024512808,
-0.03481873,
0.07659594,
-0.004200784,
-0.021086289,
0.022562329,
-0.0145495385,
-0.043437753,
-0.13632286,
-0.006082076,
0.019952899,
0.019148985,
-0.029230867,
0.012862636,
-0.0012215221,
-0.0006906583,
-0.0029965593,
0.01305373,
0.0066191177,
-0.032894608,
-0.013007604,
-0.02597567,
0.02511904,
0.015340274,
0.017409366,
-0.035398606,
-0.008170936,
0.028888214,
0.02007151,
-0.030680548,
0.026740048,
-0.00055557425,
-0.003999805,
-0.012111437,
-0.018819511,
-0.00027263912,
-0.015274379,
0.010207081,
0.0081907045,
0.006006297,
0.008322494,
-0.018977659,
-0.0063950755,
0.012249815,
-0.013264593,
-0.013996024,
0.02857192,
0.0018549344,
-0.0023096073,
0.012460678,
0.014707685,
0.009185714,
-0.0053572347,
0.0046225097,
-0.02709588,
0.0094097555,
0.035556752,
-0.026291965,
-0.0056504663,
-0.04812945,
-0.03326362,
-0.012895583,
0.01760705,
-0.029520802,
0.0072352323,
0.02610746,
-0.008487231,
0.026028387,
0.023353064,
0.013343667,
-0.018134207,
0.013508403,
0.008546536,
-0.03605755,
-0.00051521376,
-0.03481873,
0.018410966,
-0.023353064,
0.007920537,
-0.01428596,
0.0063127074,
-0.00947565,
-0.020414162,
0.008019378,
-0.0115315635,
-0.0137324445,
0.0031135222,
-0.027675753,
-0.012506804,
-0.0078678215,
0.011623816,
-0.007452685,
0.0278339,
0.020282373,
0.0071166223,
0.015089875,
-0.009277967,
-0.0041678366,
-0.0022107654,
0.019544354,
-0.015010801,
0.031234063,
0.013864234,
0.015748821,
-0.009192304,
-0.02904636,
0.015340274,
0.014220065,
-0.02154755,
0.0035780794,
-0.043516826,
0.0019949605,
-0.016526379,
-0.00018903527,
0.008203884,
-0.02930994,
-0.0072747692,
-0.0103125125,
0.008836472,
0.042884238,
-0.025540765,
0.029520802,
-0.0025797754,
0.0034594692,
-0.051318754,
-0.028782783,
0.017817913,
0.01477358,
0.021692518,
0.013851055,
-0.008968262,
-0.022694116,
0.011360237,
0.019689322,
0.011004406,
-0.00046702832,
0.0043424573,
0.018160565,
-0.005208972,
0.0033803955,
0.014918549,
-0.018516397,
-0.0060886657,
0.011070301,
-0.03186665,
-0.028308341,
-0.0014463875,
0.027148595,
0.013337077,
0.02315538,
-0.02994253,
-0.030733265,
-0.009521777,
-0.034871448,
-0.007156159,
-0.021745235,
-0.019241238,
0.022483254,
-0.005442898,
0.008487231,
0.020018794,
0.01378516,
-0.029573519,
-0.012480446,
-0.023880221,
0.011116427,
-0.0024759914,
-0.012295942,
-0.015603852,
-0.044439353,
0.025593482,
0.027306743,
0.019478459,
0.009785355,
0.015142591,
-0.022746833,
-0.032077514,
0.018028775,
-0.0017214977,
-0.030706907,
-0.02131033,
0.009304324,
-0.004349047,
0.01736983,
0.023577105,
-0.007960074,
-0.021204898,
0.0037724688,
-0.0367165,
0.025698913,
0.009778766,
0.022944517,
-0.013449098,
0.005528561,
0.021956097,
-0.008513588,
-0.0011449195,
0.022852264,
0.008144579,
0.007525169,
-0.026318323,
0.006675128,
-0.007610832,
0.0024545756,
0.031260423,
0.019887006,
0.010576091,
0.02560666,
-0.0003659212,
0.009047335,
0.0003576844,
-0.0029652591,
-0.0020789762,
-0.03004796,
0.003410048,
-0.012579288,
-0.015801536,
-0.030258823,
-0.014694506,
0.008230242,
-0.0030986958,
0.017752018,
0.007439506,
-0.0019686026,
-0.034133427,
0.0194521,
0.0016103005,
0.0035286585,
-0.016974462,
0.024605062,
0.016605452,
-0.002937254,
-0.01762023,
-0.0056208135,
0.00788759,
0.0044874256,
0.020295551,
-0.015142591,
0.026186533,
0.0033902796,
0.010806723,
-0.00039989816,
-0.04225165,
-0.019649785,
0.0033095588,
-0.008506999,
0.0347133,
0.009956681,
-0.0034331111,
0.07069178,
-0.0011556274,
-0.0042172577,
0.0037296372,
-0.003064101,
-0.0014826296,
-0.01354794,
0.020532772,
-0.009192304,
-0.02413062,
0.035029594,
0.0030937537,
0.027754826,
-0.028387414,
-0.019807931,
-0.004256794,
-0.0023903283,
0.0001967573,
-0.0028367646,
-0.007044138,
0.01083308,
-0.0068266857,
0.0083554415,
0.0016440715,
-0.023221275,
-0.0121971,
0.05134511,
0.020611847,
0.010404765,
-0.043674972,
0.008955083,
0.0022684233,
-0.018213281,
-0.016539557,
0.004510489,
-0.0024282178,
-0.016407767,
-0.02399883,
0.019293953,
0.009060514,
0.0030509222,
0.0060194763,
-0.0320248,
-0.031945724,
-0.018766796,
0.004764183,
-0.009923734,
-0.01748844,
-0.007920537
] |
During development of the vertebrate neuroepithelium, the nucleus in neural progenitor cells (NPCs) moves from the apex toward the base and returns to the apex (called interkinetic nuclear migration) at which point the cell divides. The fate of the resulting daughter cells is thought to depend on the sampling by the moving nucleus of a spatial concentration profile of the cytoplasmic Notch intracellular domain (NICD). However, the nucleus executes complex stochastic motions including random waiting and back and forth motions, which can expose the nucleus to randomly varying levels of cytoplasmic NICD. How nuclear position can determine daughter | [
-0.0026502837,
0.0047035073,
0.0059473827,
-0.007549494,
-0.029269217,
0.0034861679,
-0.016797293,
0.001620355,
-0.0126709435,
-0.0055957804,
0.020857302,
0.012120321,
0.011974373,
0.018203702,
0.0058246534,
0.0025308717,
0.017898537,
-0.001865813,
-0.013480292,
0.008484888,
-0.021547237,
0.016770756,
0.00777505,
-0.039644796,
0.001859179,
0.019636646,
-0.012617871,
-0.014196764,
0.002157709,
-0.010335775,
-0.0027282333,
0.013931404,
0.0059075784,
-0.03030412,
-0.0059208465,
0.028287383,
0.008591033,
-0.020379653,
0.011437019,
-0.009645838,
0.014913236,
0.003542557,
-0.031524777,
0.0011816815,
-0.007489788,
0.0058677746,
-0.024081426,
0.018787494,
-0.014382516,
0.02047253,
0.015457224,
0.011337509,
-0.006872826,
-0.0029886179,
-0.011682477,
-0.023484366,
0.0043419544,
-0.01528474,
-0.0122463675,
-0.021361485,
0.0059374315,
0.012584701,
0.0003615531,
0.020724623,
-0.020432726,
0.020578673,
0.0055526597,
0.009665741,
0.014767288,
0.007682174,
0.042086106,
0.022555606,
-0.022582142,
-0.003588995,
0.009811688,
-0.0067932177,
-0.025846072,
-0.009732081,
-0.025448032,
0.00717799,
0.010899665,
-0.031471703,
0.0015589905,
0.039193682,
0.0054597836,
-0.00073678885,
0.006952434,
0.011828425,
-0.016890168,
0.004481268,
0.024439663,
0.03542557,
0.0146611435,
-0.0023102912,
-0.010349043,
-0.0044912193,
0.003237393,
0.026536006,
-0.0029902763,
-0.026403327,
-0.011967739,
0.018469062,
-0.014647876,
-0.007350474,
-0.013015912,
0.00087071274,
-0.0096060345,
-0.009858127,
0.0373627,
-0.007323938,
-0.009990807,
0.013022546,
0.002250585,
-0.033196546,
0.025434762,
-0.025647052,
0.025381692,
0.015006112,
-0.0134537555,
-0.010826691,
0.016332913,
0.019517234,
0.017089188,
-0.030675624,
0.036938123,
0.027756663,
-0.0018442525,
0.00724433,
-0.0024811167,
-0.004152885,
0.0016095747,
-0.018230237,
-0.0024860923,
0.04213918,
-0.009546328,
-0.03762806,
0.009154922,
-0.016691148,
-0.010017343,
-0.029561112,
0.016332913,
0.02153397,
-0.02146763,
0.0048295534,
-0.010946103,
0.023046521,
0.004968867,
0.012684211,
0.028234312,
-0.003940597,
0.004332003,
-0.011324241,
0.044898923,
-0.020154098,
-0.016585005,
0.047950566,
-0.006494688,
0.012578067,
0.0057583135,
-0.012511727,
0.0019902005,
0.00026059189,
0.00193547,
0.00032568802,
0.026814636,
0.027677055,
0.010395481,
0.002011761,
0.00764237,
-0.018840564,
-0.021560505,
0.006720244,
-0.045456182,
-0.0019686401,
-0.019092657,
-0.0059938207,
0.001845911,
0.007861292,
-0.031683993,
-0.0050915964,
0.0027746712,
0.011025711,
0.021878937,
0.003774747,
-0.013248102,
-0.014409052,
0.027026923,
-0.016186964,
-0.015563368,
-0.0037382601,
0.00081971387,
-0.0048627234,
-0.012140224,
-0.0020863935,
-0.64026076,
-0.02073789,
0.021016518,
-0.029056927,
0.018124092,
0.035584785,
-0.0009130045,
0.00741018,
-0.0060203564,
0.016651345,
-0.007728612,
0.0154439565,
-0.003661969,
0.0012289488,
-0.047127947,
-0.034602955,
0.00034227304,
-0.02100325,
0.02770359,
-0.015921604,
-0.027491303,
-0.001829326,
-0.009970904,
0.021746257,
0.008657373,
0.024174303,
0.022436194,
0.007848024,
-0.01775259,
0.021878937,
-0.013666044,
-0.0011352436,
-0.015563368,
-0.00711165,
0.041157346,
0.014740752,
0.006458201,
0.010329141,
0.0013981159,
0.029163072,
-0.029534576,
-0.014050816,
-0.0020084442,
0.0029687157,
-0.019225337,
-0.010335775,
0.012093785,
-0.0047333604,
0.0004239542,
-0.012053981,
0.0057384116,
0.010209729,
-0.022820966,
0.015881801,
0.001027441,
-0.0021693185,
0.0069723357,
-0.0058644577,
0.016080821,
-0.0009959295,
-0.010959371,
0.010004074,
-0.022993451,
-0.009506525,
-0.003894159,
0.0017447425,
-0.010621037,
-0.008312404,
-0.005682023,
-0.02532862,
0.0025441397,
0.02126861,
-0.02186567,
-0.0007600078,
0.003801283,
0.026323719,
0.00684629,
0.0054664174,
-0.014528464,
0.01768625,
-0.011443653,
-0.017633177,
-0.038795643,
-0.0027133068,
0.010156657,
-0.0019968345,
-0.008425183,
0.023298614,
0.01259797,
-0.0010995858,
-0.0053768586,
0.01279699,
0.014037548,
-0.056574766,
-0.02751784,
0.019968346,
0.001962006,
0.0030466653,
0.007662272,
-0.03282504,
0.01482036,
-0.003807917,
0.006833022,
-0.01681056,
0.033276152,
0.002190879,
-0.024373323,
0.02252907,
0.028685424,
-0.028552745,
-0.008829856,
-0.027968952,
-0.002214098,
-0.013135323,
-0.007237696,
-0.023086326,
0.00724433,
0.023364954,
-0.0053237863,
-0.010441919,
0.009135021,
0.0013259711,
0.00050915964,
-0.005018622,
0.022913842,
0.00770871,
0.008544594,
-0.009433551,
-0.016359448,
-0.017115725,
-0.001938787,
-0.00057342654,
0.031577848,
-0.022449462,
0.031179808,
0.02378953,
0.0068595577,
-0.011596235,
-0.010083683,
-0.0366993,
-0.032878112,
0.01013012,
0.017128993,
-0.016080821,
-0.004225859,
-0.015722584,
-0.031949352,
-0.0029521307,
-0.00360558,
-0.0031926134,
0.004836187,
0.00684629,
-0.010554696,
0.0033783654,
0.028526207,
0.0011675843,
-0.0019437625,
-0.014462124,
-0.001646891,
-0.023630314,
0.006959068,
0.023165934,
-0.019835666,
0.0138783315,
-0.013102153,
-0.0058744084,
-0.023962015,
0.011602869,
0.026310451,
-0.021122662,
0.00203498,
0.0013898234,
-0.01807102,
-0.0006074258,
-0.007881194,
-0.019570306,
-0.004381758,
-0.0030599334,
-0.007595932,
-0.004265663,
-0.004123032,
-0.012750551,
-0.0016883535,
-0.011874863,
0.032931186,
0.021719722,
0.040626626,
0.03056948,
-0.008047044,
0.03423145,
-0.0021311732,
0.01901305,
0.0026884293,
0.004477951,
0.00717799,
-0.019702986,
0.030118369,
0.017381085,
-0.0063188868,
0.029746864,
0.0016377692,
-0.015987944,
-0.013480292,
-0.007051944,
0.015510296,
-0.0065013217,
-0.012418851,
-0.025036722,
-0.0135532655,
0.014103888,
0.008922732,
0.0051214495,
-0.0004044668,
-0.015045916,
-0.000116406,
0.0018210335,
-0.020897105,
0.001643574,
0.012617871,
0.003263929,
-0.010050513,
-0.018893637,
0.02743823,
0.019052854,
0.007516324,
0.012604604,
-0.008153188,
0.007138186,
0.01795161,
-0.019079389,
0.003857672,
0.014196764,
-0.015311277,
-0.008425183,
0.02352417,
0.023709923,
0.0051380345,
0.0027199409,
0.015125524,
0.002054882,
0.020817498,
0.009008975,
-0.020565405,
0.00817309,
0.007668906,
-0.0099311005,
0.038477212,
0.01482036,
-0.023444563,
0.00847162,
-0.011317607,
0.0054564667,
-0.028950784,
0.006932532,
0.006577613,
-0.0059805526,
0.0052209594,
0.0050451583,
0.04078584,
0.019968346,
-0.0023683386,
-0.021786062,
-0.0016692807,
-0.007549494,
0.011762085,
-0.004205957,
0.011171659,
-0.0010158315,
-0.021043053,
-0.009095216,
-0.021573775,
-0.003678554,
0.014249836,
-0.027066728,
0.016027749,
-0.015828729,
0.0015225034,
0.004985452,
0.022794431,
0.013188396,
0.001534113,
-0.018163897,
0.016359448,
0.030649088,
-0.011828425,
-0.014873432,
-0.018654814,
-0.012644407,
-0.008657373,
0.0049290634,
-0.0016543542,
0.025514372,
-0.014899968,
-0.013493559,
-0.025089795,
-0.0047300435,
0.00038871105,
0.010766985,
0.011762085,
-0.012140224,
0.011065515,
0.0015249911,
-0.012690846,
0.0003569922,
0.023378223,
0.012073883,
-0.008597666,
-0.02526228,
-0.003642067,
-0.0122463675,
-0.019092657,
-0.028658887,
-0.004023522,
-0.0014851872,
-0.013666044,
-0.011291071,
-0.008192992,
0.00360558,
0.037044264,
0.014329444,
-0.034178376,
-0.018906904,
-0.017354548,
-0.019994881,
0.031816673,
0.013811992,
-0.007947534,
0.016651345,
-0.021786062,
-0.013413952,
0.015961409,
0.011715647,
0.028154703,
-0.024333518,
-0.0107802525,
-0.0027978902,
0.00034496808,
-0.008989072,
0.00873698,
0.03489485,
0.008219528,
-0.013274638,
-0.008617569,
0.0069723357,
0.003774747,
-0.012332609,
0.020021418,
0.027968952,
0.0165452,
0.016757488,
0.01760664,
0.01482036,
-0.004106447,
-0.0103556765,
0.00853796,
0.0135864355,
0.011861595,
0.027199408,
-0.010123487,
-0.02911,
0.0014926504,
0.021613577,
-0.007947534,
-0.0041827383,
0.004514438,
-0.002161026,
0.007516324,
-0.030489873,
0.009307505,
0.010150023,
0.021547237,
-0.004159519,
-0.0055626105,
-0.026244111,
0.019729521,
-0.021839134,
-0.008975805,
-0.015696049,
-0.0012588018,
0.012578067,
0.0052076913,
-0.016080821,
0.0013997743,
-0.018362917,
-0.015669512,
-0.02871196,
0.008484888,
-0.010753717,
0.024678487,
-0.02770359,
-0.00037067485,
-0.008192992,
-0.021560505,
-0.023696654,
0.007980704,
-0.03322308,
-0.049755014,
-0.02033985,
0.025713392,
0.036248185,
0.01767298,
-0.014117156,
-0.023019986,
0.024068158,
-0.00350607,
-0.020857302,
-0.018336382,
-0.008776784,
-0.024001818,
0.013971208,
0.0066472697,
0.012379047,
0.01548376,
-0.01022963,
0.012604604,
-0.002290389,
0.009692277,
-0.008863026,
-0.013268003,
0.020950178,
0.033276152,
0.01647886,
0.003181004,
0.012458655,
0.007396912,
-0.030065296,
-0.0055526597,
-0.02398855,
-0.008816589,
-0.019371286,
-0.0010042221,
0.014966308,
-0.007091748,
-0.008882929,
0.013526729,
-0.02465195,
0.0108134225,
0.0015531856,
-0.0063918605,
0.020432726,
0.01761991,
0.016027749,
-0.011629405,
0.013918136,
0.010660841,
-0.0017215235,
0.031657457,
-0.003559142,
-0.013493559,
-0.0009627595,
-0.007874561,
-0.008292503,
-0.018097557,
0.008319038,
0.011576333,
0.022781162,
-0.00886966,
-0.050551094,
0.00072600855,
-0.027172871,
0.008445084,
0.008285868,
0.0020001514,
-0.022502534,
0.0068927277,
-0.0009868077,
-0.008929366,
-0.030410264,
0.026761563,
-0.032878112,
0.0017596689,
0.021228805,
0.015669512,
0.016717685,
-0.03436413,
0.0057815327,
-0.013148592,
-0.014700948,
-0.00840528,
-0.03401916,
0.0007608371,
-0.015324544,
0.017261673,
0.02365685,
0.03423145,
0.01780566,
0.014767288,
0.004822919,
0.01395794,
-0.00052823237,
-0.0010680743,
0.011131855,
-0.018190432,
0.03282504,
-0.010481723,
0.000070019814,
0.026045091,
-0.009294236,
0.017155528,
0.04805671,
0.0028459867,
-0.011901399,
0.006819754,
-0.034576416,
-0.013327709,
0.003864306,
-0.013559899,
0.0018906905,
-0.006703659,
-0.003509387,
0.00847162,
0.011165025,
-0.0057450454,
-0.015430688,
0.021786062,
-0.013294539,
0.010335775,
-0.0043784413,
0.0050053545,
-0.01760664,
0.007668906,
0.0014719191,
-0.019888738,
0.015868532,
0.0000037121904,
0.034337595,
0.020114293,
0.013705848,
-0.0051114983,
0.01442232,
-0.025647052,
-0.013327709,
-0.006491371,
-0.007728612,
-0.018376185,
-0.028791567,
-0.010886397,
-0.019132461,
0.0013292881,
-0.0005182814,
-0.010873129,
0.019729521,
-0.0021361485,
-0.014196764,
0.013679312,
-0.022582142,
0.003370073,
-0.025249012,
0.01800468,
0.015881801,
-0.010481723,
-0.028552745,
-0.02511633,
-0.012120321,
0.019092657,
0.05540718,
0.019822398,
0.013533364,
-0.0018110825,
0.0044912193,
0.007821488,
-0.018110825,
-0.042829115,
0.0143029075,
-0.008478254,
-0.004189372,
-0.020047953,
-0.003588995,
-0.016014481,
0.012319341,
0.0014951382,
-0.012153491,
0.010886397,
-0.0060634776,
-0.038371067,
0.004365173,
-0.00013724092,
0.018124092,
0.011868229,
0.012299439,
-0.008743614,
-0.014462124,
-0.011111953,
0.027225943,
0.005861141,
0.013546632,
-0.008564496,
-0.0063089356,
0.022422927,
0.0082991365,
-0.007967436,
-0.004106447,
-0.004388392,
0.04248415,
-0.019212069,
-0.003297099,
0.004905844,
0.0019105925,
0.027079996,
-0.012571434,
-0.016226768,
0.0071514538,
-0.03335576,
-0.0049821353,
0.024240643,
0.007828122,
0.0057284604,
-0.020445993,
-0.022422927,
0.0064548836,
-0.047552526,
-0.003990352,
0.0014254812,
-0.034390666,
-0.01681056,
0.019384554,
0.03083484,
-0.0038609891,
0.0054796855,
-0.0011020736,
-0.011742183,
0.026801368,
-0.0023733142,
0.008212894,
0.02352417,
0.018296577,
-0.03723002,
0.015098988,
-0.017182065,
-0.016041016,
-0.009334041,
-0.03781381,
-0.003807917,
0.0025126282,
-0.003897476,
0.043174084,
0.008159822,
-0.0115298955,
-0.00387094,
0.02884464,
0.0061762556,
-0.0005763289,
-0.024957115,
0.015682781,
-0.0057417285,
-0.0057583135,
0.0083986465,
-0.012372414,
-0.007204526,
-0.017261673,
-0.015682781,
0.031869743,
-0.028366992,
0.0061828895,
-0.009937734,
-0.010435285,
-0.012372414,
0.001153487,
0.0051413514,
0.0023832652,
-0.026522739,
0.003914061,
0.00039721085,
-0.0062459125,
-0.01508572,
0.011695745,
0.0057848496,
0.014581536,
-0.0031760284,
-0.014515196,
0.019132461,
-0.035850145,
-0.03547864,
0.017487228,
-0.012710747,
0.027491303,
0.026469667,
-0.015788924,
-0.01382526,
-0.034576416,
-0.043492515,
-0.024373323,
0.022847502,
-0.0029106683,
0.0059838695,
-0.011881498,
-0.001733133,
-0.014316176,
-0.000964418,
0.0095728645,
-0.01528474,
-0.0066340016,
0.03388648,
-0.0033087083,
0.0025673588,
0.0065477598,
-0.0049091615,
-0.030357193,
0.015470493,
0.014767288,
-0.0023335102,
0.009533061,
-0.012272904,
0.016797293,
-0.0030765184,
0.010959371,
0.006086697,
0.032267787,
0.021016518,
-0.021295145,
-0.013639508,
0.00038415016,
-0.013666044,
-0.01747396,
-0.00076995883,
-0.0057284604,
0.01561644,
0.010494991,
-0.025607247,
-0.029879544,
0.027756663,
-0.00046686787,
0.027040191,
0.031710528,
0.007231062,
0.027889343,
0.019928541,
-0.0012447046,
-0.013049082,
-0.019517234,
-0.041688066,
-0.018362917,
0.0028476452,
-0.0007678857,
0.012306074,
0.01848233,
0.0043121013,
-0.039750937,
-0.0041827383,
-0.0017480595,
-0.0031262734,
-0.043837484,
0.018469062,
0.0022870721,
-0.017049385,
-0.0012878256,
-0.006952434,
-0.02730555,
-0.027544376,
-0.011636039,
-0.003897476,
-0.013904868,
0.019318214,
0.0056654373,
-0.00047681888,
0.009718813,
0.0162135,
-0.009745348,
0.004053375,
-0.0057981177,
0.19519886,
0.006627368,
0.0030864694,
0.008783419,
-0.003625482,
-0.003744894,
0.026164504,
0.009984173,
0.016585005,
-0.0004772335,
0.013506828,
0.00850479,
-0.0064349817,
0.00033667558,
0.03380687,
-0.016531933,
-0.027836272,
-0.013195029,
-0.013719115,
-0.01016329,
0.017235138,
-0.026098164,
-0.0051977406,
0.014992844,
0.031445168,
0.0062094256,
-0.046862587,
0.016598273,
0.011629405,
0.01740762,
-0.0134537555,
0.003801283,
0.0040334733,
0.007536226,
0.020976713,
-0.012027445,
-0.006332155,
-0.0042125913,
-0.0013914818,
-0.0006965702,
0.024426395,
-0.016001211,
0.001034075,
0.013838528,
-0.019185534,
0.036407404,
0.006756731,
0.003247344,
-0.0032224664,
-0.00042374685,
-0.054133456,
0.0010813423,
0.014130424,
0.0029023758,
-0.008664006,
0.013042447,
0.008100117,
0.010428651,
0.0054465155,
0.038264923,
-0.022038154,
0.029428432,
-0.04054702,
0.03335576,
0.008610934,
0.00850479,
0.0014487001,
-0.003821185,
0.020485798,
-0.028101632,
0.013798724,
0.00436849,
-0.02166665,
-0.0063885436,
0.009453452,
-0.027119799,
0.02518267,
0.0050418414,
0.02120227,
0.009075315,
0.026867708,
0.0162135,
-0.019265141,
-0.0023102912,
-0.0041993232,
-0.03762806,
0.025142867,
0.0033750485,
-0.022688286,
-0.021043053,
0.020764425,
-0.010893031,
-0.01773932,
0.007556128,
-0.0019769326,
-0.00780822,
0.014011011,
0.0062956675,
-0.02511633,
0.0043618563,
-0.02458561,
0.060289808,
0.04240454,
0.0080404105,
0.0019736155,
0.012617871,
0.01821697,
0.012505094,
0.0011310973,
-0.01641252,
0.00094202824,
0.00093705277,
0.007987338,
-0.0015299667,
-0.003681871,
0.00833894,
-0.012976107,
-0.04152885,
0.054929536,
-0.02146763,
0.0026403328,
-0.03415184,
0.009513158,
0.04354559,
-0.009513158,
-0.01515206,
-0.01780566,
0.007748514,
0.008518058,
-0.01861501,
-0.0037946492,
-0.022993451,
-0.008909465,
0.01793834,
0.010335775,
-0.018535402,
0.006574296,
-0.01727494,
-0.007118284,
0.021056322,
-0.013559899,
0.009280968,
0.04081238,
0.0063056187,
0.0021527335,
-0.008445084,
0.022807699,
0.026217574,
-0.018137362,
-0.029189607,
-0.024161035,
-0.007549494,
0.0100306105,
0.0022223906,
0.007290768,
-0.027093263,
-0.031020593,
-0.025806267,
-0.003386658,
0.011655942,
-0.025739927,
0.0152184,
-0.0053868094,
-0.02020717,
-0.010720547,
-0.00056264625,
-0.16696456,
0.00886966,
0.045111213,
-0.019225337,
0.02498365,
0.038769107,
0.010103585,
-0.005048475,
0.0008122506,
0.02140129,
0.024678487,
0.012657676,
-0.031790137,
-0.029879544,
0.011191561,
0.017168798,
-0.006985604,
0.04107774,
-0.0003283831,
0.003907427,
0.02045926,
-0.010368945,
0.031312488,
0.0019902005,
-0.0005062573,
0.009864761,
-0.019848933,
-0.008352208,
-0.0017447425,
-0.023019986,
0.011125221,
-0.0022190737,
0.028791567,
-0.0005141351,
0.01881403,
0.0051977406,
-0.008584399,
0.0029687157,
-0.004252395,
0.017062653,
-0.0015614781,
0.02093691,
-0.000977686,
-0.003943914,
-0.006395178,
0.01694324,
-0.032241248,
-0.018641545,
0.020286778,
-0.019623376,
0.016823828,
-0.013772188,
-0.0087900525,
0.011616137,
0.026031824,
0.0012405583,
0.0021079541,
0.016704416,
0.030649088,
-0.01801795,
0.00015579538,
-0.0076224683,
0.030887913,
0.0052209594,
-0.0063586906,
-0.020379653,
-0.000462307,
0.030516408,
-0.05177175,
-0.0056621204,
-0.013221566,
0.0034463638,
0.014833628,
-0.016624808,
0.018243505,
0.011941203,
0.0045840954,
-0.003824502,
-0.016823828,
0.014807092,
-0.031737063,
0.018256772,
-0.015696049,
-0.0251296,
-0.023404758,
-0.012850061,
0.0058744084,
0.016784025,
0.00383777,
-0.001554015,
-0.0048162853,
-0.031365562,
0.01468768,
-0.0058909934,
0.054398816,
0.021626845,
0.0022621946,
-0.004086545,
-0.0013682629,
0.004152885,
0.007788318,
-0.0070718457,
-0.027862808,
0.022741359,
0.030277584,
-0.0011120245,
-0.011735549,
0.020631745,
0.049356975,
-0.016969776,
0.014700948,
-0.011364046,
0.009632571,
0.0050783283,
-0.015921604,
0.04288219,
0.003068226,
0.0059009446,
-0.00360558,
-0.0154439565,
0.06267805,
0.0029521307,
-0.014117156,
0.016200233,
-0.003263929,
-0.026336987,
-0.13384762,
-0.029348824,
-0.011423751,
0.025381692,
-0.014767288,
0.012869963,
0.0004245761,
0.015112256,
-0.002978667,
0.031020593,
-0.0172086,
-0.0031992474,
0.0052010575,
-0.006269132,
0.013904868,
-0.013327709,
0.019464161,
-0.00030018858,
-0.024041623,
0.025938947,
-0.021560505,
0.00008489449,
-0.015138792,
-0.018588472,
0.0058014346,
0.013865064,
-0.026774831,
0.009022242,
0.02871196,
0.00017289867,
0.009652473,
-0.029322287,
0.02233005,
-0.003930646,
-0.026602346,
-0.009287602,
-0.020724623,
-0.02599202,
0.037973028,
-0.03393955,
0.0029289117,
0.0020565405,
0.014064084,
-0.0055725616,
-0.018588472,
-0.020114293,
-0.017858732,
0.008464986,
0.0086043,
0.0022887306,
-0.016704416,
-0.019397821,
-0.023205739,
-0.0069723357,
0.003950548,
-0.015961409,
0.007841391,
-0.0012546555,
-0.01402428,
-0.00061862066,
0.0005166229,
0.012053981,
-0.0011385606,
-0.02087057,
0.045403108,
-0.00867064,
-0.03661969,
-0.024572343,
0.037919953,
-0.02491731,
-0.014435588,
0.014103888,
-0.002290389,
0.020512333,
-0.022913842,
-0.0172086,
-0.011768719,
0.023630314,
0.0018143995,
-0.006235962,
-0.010269435,
-0.025846072,
0.020366386,
-0.004242444,
0.028287383,
0.02451927,
0.013340978,
-0.0030333973,
0.009274335,
-0.00350607,
-0.0029421798,
0.026748296,
-0.0025557491,
-0.03688505,
-0.010508259,
0.010110219,
0.018575205,
-0.0020333217,
0.022542339,
0.0059241634,
-0.016385984,
-0.014873432,
-0.044580493,
0.0065676617,
-0.02499692,
-0.0047532623,
0.01246529,
-0.02791588,
0.006524541,
-0.017580105,
-0.0045840954,
0.022754626,
-0.004030156,
0.021175735,
-0.0043286863,
0.0051745214,
-0.030357193,
-0.021109393,
0.009745348,
-0.0114967255,
0.00717799,
0.0251296,
0.010647573,
-0.011689112,
0.02027351,
-0.016080821,
-0.025434762,
-0.0165452,
-0.01276382,
-0.00029770084,
0.019663181,
-0.0023119496,
0.019158997,
-0.040095907,
0.012266269,
0.0015415761,
-0.011503359,
-0.011662575,
-0.016120624,
0.016651345,
0.048958935,
0.030357193,
-0.02219737,
-0.039246753,
0.0003437242,
-0.0095396945,
-0.016200233,
0.00023177544,
-0.03534596,
0.0022688287,
-0.017195333,
-0.010959371,
0.031604383,
0.0068263877,
0.012505094,
-0.023895675,
-0.016929973,
-0.008478254,
-0.006720244,
0.0026519422,
-0.014011011,
-0.0056422185,
0.031126736,
0.016465593,
0.0122795375,
0.009791787,
0.009844859,
-0.031922817,
-0.036805443,
0.009712178,
-0.013287906,
-0.023577243,
-0.014462124,
0.001882398,
0.02080423,
-0.0020698085,
-0.015841996,
0.0014652852,
-0.0057450454,
0.0011145123,
-0.021573775,
0.009022242,
0.007018774,
0.012034079,
-0.000888127,
0.015735852,
0.047870956,
0.010050513,
-0.01894671,
0.030914448,
-0.00076042244,
-0.0055725616,
-0.0061298176,
0.003443047,
0.01760664,
0.011582967,
0.010116853,
0.0059772357,
-0.01276382,
0.024134498,
0.00624923,
0.025952214,
-0.004431513,
-0.00042706387,
0.0059075784,
-0.020658283,
0.0064681517,
0.01661154,
-0.013599704,
-0.03661969,
-0.009625937,
-0.019437626,
-0.0059473827,
0.00023737288,
-0.004053375,
0.004839504,
-0.031524777,
0.00731067,
0.0024545807,
-0.008843125,
-0.0030615919,
0.0102628,
0.014130424,
-0.00043079548,
-0.0041827383,
-0.010203095,
0.019689718,
0.0059440657,
0.03542557,
-0.021361485,
0.038609892,
-0.009453452,
0.030410264,
0.012816891,
-0.015895069,
-0.0008325672,
-0.011390581,
-0.015045916,
0.016863633,
0.010528161,
-0.03587668,
0.08857719,
0.00077990984,
-0.019756058,
-0.019397821,
-0.023736458,
0.013055716,
0.001895666,
0.0102628,
-0.0115298955,
-0.035000995,
0.007025408,
-0.032453537,
0.025899144,
-0.011815157,
0.0083986465,
0.027544376,
-0.023219006,
0.009327407,
0.01874769,
-0.0033949504,
0.023139399,
-0.038371067,
0.023404758,
0.032533146,
-0.023232274,
0.0138916,
0.008319038,
-0.017527033,
-0.0015664537,
-0.0048925765,
0.0056621204,
-0.007761782,
-0.039114073,
0.013387416,
-0.0020698085,
0.010216363,
-0.00403679,
-0.02160031,
-0.0024894092,
0.04447435,
-0.0079409005,
0.007264232,
-0.0009287603,
-0.022210639,
-0.0043253694,
0.011629405,
0.0011717306,
-0.016240036,
-0.03462949
] |
Following prolonged exposure to an odorant, C. elegans exhibits a diminished response to the odorant for several hours. This olfactory adaptation is odorant selective; animals can adapt independently to different odorants sensed by a single pair of olfactory neurons, the AWC neurons. The mechanism of olfactory adaptation is genetically complex, with different genes required for adaptation to different odorants. Animals mutant for the gene adp-1 fail to adapt to a subset of AWC-sensed odorants; adp-1 affects a calcium-dependent process required for adaptation. Mutations in another gene, osm-9, affect adaptation to a | [
-0.00041550913,
0.015295081,
0.004946836,
-0.005301136,
-0.027408144,
0.02842425,
0.0036265652,
-0.006156805,
-0.022020103,
-0.013383196,
0.004656042,
0.028798604,
-0.0034176619,
0.0035964833,
-0.028290551,
-0.011223969,
0.03986882,
0.019653644,
-0.012046213,
0.019626904,
-0.014987575,
0.020509314,
0.0012283528,
-0.013891249,
0.021030737,
0.013931358,
0.0060899556,
-0.051313393,
-0.0035563738,
-0.011304188,
0.0074269385,
0.014974205,
-0.012835033,
-0.0071060625,
-0.012006104,
-0.01845036,
0.009900356,
-0.02378492,
0.013998208,
-0.007219706,
-0.00032818745,
0.009258605,
-0.010147698,
0.005478286,
-0.01699305,
0.015054424,
-0.03449415,
-0.02222065,
-0.011344298,
0.010655751,
0.006133408,
0.0045490833,
0.0074202535,
0.012159857,
-0.007313295,
-0.009338823,
0.024373192,
0.011264078,
0.0076609105,
0.0063306126,
0.002065638,
0.013289607,
-0.019105481,
0.01766154,
-0.03369196,
-0.00021203708,
0.012574322,
0.0018868167,
0.00654453,
-0.0002310473,
0.047195487,
0.012220021,
-0.008289292,
0.0011665173,
0.039788604,
0.007213021,
-0.03818422,
0.01766154,
-0.017367404,
0.0048298496,
0.01681924,
-0.0475431,
-0.0021608982,
0.03847836,
0.012440623,
0.0073467195,
0.00046418366,
-0.007888197,
-0.008690387,
0.0097198635,
0.01772839,
0.021592269,
0.017928937,
0.014372563,
0.0007545595,
0.0030132246,
0.012801608,
0.03152605,
-0.02231424,
-0.024493521,
-0.024907986,
0.024720808,
-0.0035998255,
-0.021057475,
0.0028544578,
0.0005799162,
0.017447622,
0.006253736,
0.01693957,
-0.019613534,
0.0040310025,
0.030082108,
-0.013149224,
-0.05369322,
0.0039641536,
-0.01688609,
0.01073597,
0.003499552,
-0.015816504,
-0.017741758,
0.0149207255,
0.037809867,
-0.0005372999,
-0.011197229,
0.013630537,
0.024105797,
0.0007645869,
-0.013082375,
-0.025763655,
-0.016257709,
0.010595587,
0.0076475404,
0.030162327,
0.031151695,
-0.023156539,
0.027287815,
-0.023530893,
0.00018686421,
-0.0029981835,
-0.008643593,
0.014051687,
0.02393199,
-0.032916512,
0.01909211,
-0.014800398,
0.017501103,
0.028130114,
0.019680385,
0.007741129,
0.007353404,
-0.00421818,
-0.01839688,
-0.0063072154,
-0.01461322,
0.010956572,
0.041152325,
0.023236757,
0.007092693,
-0.007233076,
-0.0030733887,
0.0016678858,
-0.010655751,
-0.0050337394,
0.0015107903,
0.008376196,
0.018263182,
0.01845036,
0.002678979,
0.0028678277,
-0.0032672512,
-0.0039574686,
-0.0005602793,
-0.0035262916,
0.056474146,
0.0055819023,
0.019840822,
0.0021809528,
0.010929833,
-0.011304188,
-0.010756025,
-0.021003997,
0.0068854606,
0.001749776,
-0.028932303,
-0.004278344,
-0.013917989,
0.0041613583,
0.020602902,
0.015228231,
-0.007928307,
-0.027167486,
0.011010052,
-0.0098669315,
0.009813452,
-0.63918465,
-0.0089176735,
-0.00767428,
-0.0062002568,
0.014506261,
0.030616902,
0.0093923025,
0.0039674956,
-0.0033491415,
0.027341295,
0.000383338,
-0.0015366944,
0.03171323,
-0.026779762,
-0.017875457,
-0.014212125,
0.015174752,
-0.011330928,
0.041981254,
0.01302221,
-0.021806186,
-0.019412987,
-0.009686439,
0.0017180226,
0.008443045,
0.017327294,
0.0010035726,
-0.042810183,
-0.007894882,
0.02530908,
-0.012006104,
0.019292658,
-0.0065345024,
0.00031147516,
0.06075249,
0.005688861,
-0.002841088,
0.016484996,
0.02461385,
0.030563422,
-0.011631749,
-0.015816504,
0.0035028944,
-0.005461574,
-0.03382566,
0.005732313,
-0.012814978,
0.014212125,
0.014198755,
-0.04016296,
0.020616272,
0.01264117,
-0.007848088,
0.0038839343,
0.038638797,
-0.009886987,
0.02155216,
-0.011317558,
0.014078427,
0.018998522,
0.0015717902,
0.021953255,
-0.006601352,
-0.011685228,
-0.010575532,
0.020549422,
-0.03772965,
0.017621431,
-0.0048632743,
-0.025068425,
0.010294766,
0.041847557,
-0.001186572,
0.026672803,
-0.004940151,
0.020388985,
-0.013496839,
0.017086638,
0.0051039313,
0.013262867,
0.015843244,
-0.0035262916,
-0.03700768,
0.0056922035,
0.003009882,
-0.014359193,
-0.015776394,
0.005140698,
-0.016364668,
-0.016525105,
-0.001043682,
0.031980623,
-0.01383777,
-0.027809238,
-0.02149868,
0.019038633,
-0.024720808,
0.021712597,
-0.0025753628,
-0.02922644,
-0.009325454,
-0.00768765,
-0.0052409717,
-0.030296026,
0.01850384,
-0.01152479,
-0.013409936,
0.009679754,
0.044548262,
-0.006601352,
-0.010903093,
-0.00884414,
-0.011257393,
0.0055083684,
-0.018316662,
-0.011798872,
0.016672174,
0.019466467,
-0.004020975,
-0.03224802,
0.01463996,
0.0035831134,
-0.007547267,
-0.014813767,
0.0029881562,
0.006046504,
-0.0155624775,
-0.020990627,
-0.0023748153,
-0.0062771332,
0.016645433,
0.0066882554,
-0.008616853,
-0.0035931407,
-0.019546686,
0.02378492,
0.020897038,
0.004224865,
0.018102745,
-0.019733863,
-0.03454763,
0.008550004,
-0.0089176735,
-0.021873035,
-0.0066748857,
-0.0010578874,
0.0074135684,
0.01684598,
-0.0076542255,
-0.0063573522,
0.018076004,
-0.00036432775,
-0.020282026,
0.03855858,
0.010682491,
0.00020368095,
-0.0013486812,
-0.024480151,
-0.027916197,
-0.0090781115,
0.019519946,
0.005805847,
0.019332768,
0.014466152,
-0.024867876,
-0.02601768,
0.012026158,
0.022835663,
0.0022461307,
-0.022488046,
0.004906726,
-0.02148531,
-0.0018901591,
0.012433938,
0.002635527,
0.011337613,
-0.026632693,
-0.023263497,
-0.01462659,
-0.0036666747,
0.0077277594,
-0.01696631,
-0.016284447,
-0.012427254,
0.040136218,
0.010869669,
0.02223402,
0.02922644,
0.008677017,
0.03679376,
0.005872696,
0.0033909222,
-0.012507472,
-0.0032455253,
-0.01459985,
-0.018557318,
0.024306344,
0.004335166,
0.030937778,
0.051045995,
0.0062771332,
-0.02616475,
-0.00029622522,
-0.0095527405,
0.028130114,
-0.021351611,
0.0033775524,
-0.01032819,
0.012661225,
-0.0015684477,
-0.0070392136,
0.009365563,
0.010789449,
0.0023296922,
-0.003880592,
0.02911948,
0.0029998547,
0.008971153,
0.007313295,
0.003924044,
-0.0028912248,
-0.018864825,
0.023143169,
-0.010147698,
-0.017260445,
0.025162013,
-0.0063139005,
0.018249812,
0.008590113,
-0.006230339,
0.009920411,
0.000885751,
0.0016620365,
0.006611379,
-0.0075071575,
0.007126117,
-0.0029814711,
0.0045056315,
0.016230969,
0.021886405,
0.00481648,
0.028691646,
0.00023940345,
-0.009465837,
-0.009412358,
-0.016765762,
0.021017367,
0.028825345,
-0.02008148,
0.0032237994,
-0.016311187,
-0.010542108,
-0.013483469,
0.004552426,
-0.013109114,
-0.010261341,
0.015816504,
0.022661855,
0.030108849,
0.03698094,
0.0055484776,
-0.012487417,
-0.006013079,
-0.021231284,
0.004930123,
0.004144646,
0.014278974,
0.00090162765,
0.00670831,
-0.0012550924,
-0.016364668,
-0.017140117,
-0.028852085,
-0.02065638,
0.015656067,
0.0015793107,
-0.016752392,
-0.00020399429,
0.0097131785,
0.0056855185,
-0.015535737,
-0.021766076,
0.023651222,
0.026980309,
-0.0055083684,
-0.024266234,
-0.012995471,
0.008242498,
-0.013249498,
-0.0014614891,
-0.010575532,
0.008777291,
0.0071194326,
-0.00005556834,
0.0020121587,
0.016792502,
0.015295081,
-0.027809238,
0.02393199,
-0.026512366,
0.0066280914,
0.005060479,
-0.0077010198,
-0.013677332,
0.027314555,
-0.0063807494,
-0.00729324,
-0.028932303,
-0.008262552,
-0.024934726,
0.0032388403,
-0.004211495,
0.0022812265,
-0.016418146,
-0.0066381185,
-0.002622157,
-0.0042282073,
-0.00692557,
0.022274131,
0.0063239275,
-0.0016904473,
-0.028878825,
-0.004786398,
-0.02008148,
0.032916512,
0.008202388,
-0.011350982,
0.017273815,
-0.012159857,
-0.009338823,
-0.011491366,
-0.0075606364,
0.021886405,
0.011357667,
-0.044013467,
-0.0010879696,
0.028718386,
-0.003018238,
0.02236772,
0.006450941,
-0.0109766275,
-0.037809867,
-0.0072531304,
0.00070108025,
-0.0018065977,
-0.009699808,
0.020415725,
0.040243175,
-0.0023748153,
0.007440308,
0.0047730277,
0.030429725,
-0.002687335,
-0.0064609684,
0.009191755,
-0.019760603,
0.0074937874,
0.028049896,
0.0028110058,
-0.0023096374,
-0.00259876,
0.04291714,
-0.0011698598,
-0.014934096,
0.023571003,
0.0033491415,
-0.0019570084,
-0.014252234,
-0.012066268,
-0.006036476,
-0.005454889,
0.030189067,
-0.016779132,
-0.026940199,
0.03302347,
-0.031124955,
-0.008102114,
-0.0030265944,
0.027007049,
0.0144527815,
0.014385933,
0.0022962675,
0.020282026,
-0.014265604,
-0.020562792,
-0.007313295,
-0.009913726,
-0.018196333,
-0.024466781,
0.009505946,
0.00404103,
0.0010169424,
-0.02619149,
-0.026726281,
-0.010461889,
-0.030135589,
-0.023624482,
0.00071152544,
0.014466152,
0.029707754,
0.023169909,
-0.03315717,
-0.01032819,
0.028985783,
-0.0050705066,
-0.015522368,
-0.017862087,
-0.013423305,
0.015883353,
0.019052003,
0.012253446,
0.001567612,
-0.020228546,
-0.010154383,
0.012012789,
-0.013216073,
0.019773973,
0.016484996,
0.0017664883,
0.00134701,
0.019560056,
0.03593809,
0.0055551627,
-0.03305021,
0.0053479304,
-0.0116050085,
-0.013403251,
-0.01925255,
-0.009111537,
-0.028504469,
0.003529634,
0.017862087,
-0.008957784,
-0.0032906483,
-0.011050161,
-0.014038317,
-0.010161067,
-0.006333955,
0.010468573,
0.030242546,
-0.015214862,
0.022581637,
0.011030107,
0.0007934156,
0.0076609105,
-0.033397824,
0.02767554,
0.023544263,
-0.021244654,
0.014305714,
-0.024226125,
0.010161067,
-0.021057475,
0.006845351,
-0.008376196,
0.037997045,
0.014305714,
-0.040403616,
-0.021939885,
0.004194783,
-0.007353404,
0.015869983,
-0.026512366,
-0.02458711,
-0.011371037,
-0.012199966,
0.0049902876,
-0.006965679,
0.032408457,
-0.036633324,
-0.005812532,
-0.00365999,
0.015295081,
-0.002622157,
0.004224865,
-0.0067517622,
-0.003228813,
-0.01194594,
-0.005277739,
-0.039440986,
-0.0007996827,
-0.009452467,
0.014693439,
0.025817133,
0.010468573,
0.0028160196,
0.00538804,
0.02528234,
-0.013690702,
0.00009839356,
-0.0042883717,
0.017942306,
-0.008001841,
0.028905563,
0.015976941,
0.0076408554,
0.023263497,
-0.009739919,
0.018009156,
0.030509943,
-0.009572796,
-0.021351611,
-0.0136639625,
-0.03617875,
-0.00538804,
0.021939885,
0.0017547896,
0.00063172425,
-0.0051674377,
-0.011999419,
0.024827767,
0.020068109,
0.0044989465,
-0.028905563,
0.03898641,
-0.015829874,
0.017755128,
-0.011297503,
-0.0035129217,
-0.0026923488,
-0.029654274,
-0.0017380774,
-0.0030984571,
0.010274711,
-0.004946836,
-0.002856129,
0.0019820768,
-0.0053145057,
0.0016787488,
0.002035556,
-0.0055484776,
-0.031552788,
-0.016792502,
-0.01268128,
-0.03222128,
-0.027515102,
-0.02464059,
-0.019332768,
-0.01032819,
0.026271708,
-0.013316346,
0.03767617,
-0.0043084263,
-0.037355293,
0.031285394,
0.0038337975,
0.045056313,
-0.039574686,
0.03687398,
0.0032622376,
0.0013060649,
-0.0116050085,
-0.0067851865,
-0.012367089,
0.023651222,
0.030884298,
0.011284133,
-0.009686439,
-0.0074269385,
0.0120863225,
0.0044421246,
-0.027261075,
-0.03002863,
0.013690702,
0.010862984,
0.01853058,
-0.013069005,
-0.027287815,
0.007868143,
0.01853058,
-0.013757551,
-0.009505946,
0.01768828,
-0.0067517622,
-0.0048733014,
0.0051273284,
0.01696631,
-0.0042148377,
0.02236772,
0.007894882,
0.0011447914,
-0.007520527,
-0.021231284,
-0.0092318645,
0.0029747863,
0.0077344445,
-0.0036934144,
0.00462596,
0.0043886453,
0.0131893335,
-0.0029697726,
0.0010670793,
-0.015910093,
0.038050525,
-0.028825345,
-0.035135902,
0.0076475404,
-0.00094507955,
-0.009372248,
0.007213021,
-0.009051372,
-0.020161698,
-0.015763026,
0.0039006467,
0.024734179,
0.0074871024,
0.0062737907,
-0.019158961,
-0.028718386,
0.010842929,
-0.030215807,
-0.0130288955,
-0.012353719,
-0.020175068,
0.016765762,
0.010495313,
0.007199651,
0.025589846,
0.008142224,
-0.021324873,
-0.0029029234,
0.0352696,
-0.029333398,
0.019412987,
-0.0029346768,
0.00046752612,
-0.024105797,
0.022782184,
-0.008362826,
-0.03302347,
0.017260445,
-0.023504155,
-0.04385303,
-0.0013227771,
-0.018757867,
0.0116050085,
0.0037234966,
-0.012353719,
-0.002964759,
0.017327294,
0.035002206,
-0.021351611,
-0.01685935,
-0.02386514,
-0.033531524,
-0.004211495,
0.045163274,
-0.023691332,
0.003016567,
0.0042716595,
-0.006979049,
0.008971153,
-0.0077010198,
-0.026218228,
-0.018289922,
-0.0050136847,
0.013931358,
-0.019546686,
-0.0014138591,
-0.041232545,
-0.016712282,
0.020215176,
0.0056186696,
-0.024680698,
-0.013269552,
-0.006577954,
-0.007553952,
0.018236443,
0.0031753336,
0.010481943,
-0.008890934,
-0.025616586,
-0.03382566,
-0.006247051,
-0.022461308,
0.021832926,
0.032889772,
0.00052518345,
-0.01455974,
0.012373774,
-0.006852036,
-0.01689946,
-0.0024333084,
-0.007139487,
0.0044187275,
0.019439727,
-0.0026605953,
-0.0009634631,
0.01925255,
0.024921356,
-0.001474859,
-0.02460048,
0.017821979,
-0.005672149,
0.01921244,
0.009318769,
-0.01926592,
0.0116050085,
0.027314555,
-0.016364668,
-0.017354034,
0.01854395,
-0.018182963,
0.012427254,
-0.0061935717,
0.02074997,
0.004194783,
0.017113376,
0.0032973334,
-0.017928937,
-0.0071929665,
0.009318769,
-0.02775576,
-0.006247051,
0.017100008,
-0.0047028363,
0.006036476,
0.02390525,
-0.02308969,
-0.030911038,
0.0065244753,
-0.015228231,
0.013242813,
0.017193597,
-0.010461889,
-0.0020606245,
0.0017748444,
-0.024720808,
-0.047088526,
-0.02528234,
-0.021324873,
0.01386451,
-0.0052677114,
-0.0018266524,
0.0053312182,
-0.0023079661,
0.011203914,
-0.04016296,
-0.008984523,
-0.015107904,
0.0034594424,
-0.014827137,
0.031285394,
0.007787924,
-0.013891249,
0.006561242,
-0.016271079,
-0.0029848136,
-0.026498996,
-0.0339861,
-0.0032388403,
-0.029066002,
-0.005090561,
0.005438177,
-0.013904619,
0.007239761,
-0.035242863,
-0.010969942,
-0.015615957,
0.00071194326,
0.17466341,
-0.002570349,
-0.0012860101,
0.019319398,
-0.0032605664,
0.0025937462,
0.008402935,
0.006965679,
-0.0012275171,
0.02922644,
0.007914937,
0.014065057,
-0.0012241747,
0.008717126,
-0.011591639,
-0.02458711,
-0.024292974,
0.0002778417,
-0.025175381,
0.005585245,
0.018958414,
0.0021859666,
-0.0053145057,
-0.012166542,
0.04698157,
-0.000970148,
-0.036419407,
-0.031846926,
-0.008429675,
0.018958414,
-0.01455974,
-0.011076901,
0.015829874,
-0.0025736915,
0.006083271,
-0.00091249065,
-0.011584954,
-0.00653116,
0.0026923488,
-0.00028285538,
0.020268656,
0.006932255,
-0.0007959225,
0.009940466,
-0.020201808,
0.04601894,
0.0323015,
-0.030189067,
-0.02759532,
0.0016068859,
-0.016792502,
0.017033158,
-0.010134328,
0.016645433,
0.02528234,
-0.026485626,
0.034012835,
0.00040631735,
-0.018076004,
0.050430983,
-0.03671354,
0.0034828396,
-0.01680587,
0.017928937,
-0.0059863394,
0.03168649,
-0.032114323,
0.0001301469,
0.019613534,
-0.01461322,
-0.004325139,
-0.024239495,
-0.016618693,
0.005775765,
-0.026712913,
-0.0028210334,
0.00575571,
0.03382566,
0.010461889,
-0.0024550343,
0.00919844,
-0.018289922,
-0.036499623,
0.022889143,
-0.025910722,
-0.03219454,
0.026258338,
0.00805532,
-0.014680069,
0.0064108316,
0.0044922614,
-0.024827767,
-0.00848984,
-0.0008468949,
0.010013999,
-0.022528157,
0.022862403,
-0.000034913002,
0.00042908784,
0.0027909512,
-0.017273815,
0.04773028,
-0.0058325864,
0.006648146,
-0.0020455834,
0.030055368,
-0.0036299077,
0.024172645,
0.021926515,
-0.012306925,
-0.013757551,
-0.0005372999,
-0.011805557,
-0.015816504,
0.0037101267,
0.009826822,
0.009913726,
-0.0122333905,
0.028504469,
-0.013396566,
-0.0014957493,
-0.022274131,
-0.0069589945,
0.013536949,
0.019105481,
-0.008262552,
-0.035002206,
0.00885751,
0.026565844,
-0.034681328,
0.020589532,
-0.00073241576,
-0.02847773,
0.0003611942,
0.0041914405,
0.00027115678,
-0.005866011,
-0.025202122,
-0.018784605,
-0.0057156007,
-0.0033274156,
-0.0100340545,
0.047329184,
0.018610798,
-0.008590113,
-0.004174728,
0.01842362,
0.014706808,
-0.015522368,
0.0077277594,
0.0044120424,
-0.025108533,
0.0076141157,
0.00047379322,
-0.008837455,
-0.026097901,
-0.029520575,
-0.02770228,
0.0060966406,
-0.009332138,
-0.0051440406,
0.0052509992,
0.014987575,
-0.005688861,
0.011364352,
-0.0052476567,
-0.16856676,
0.013396566,
0.0061768596,
-0.035135902,
0.0097198635,
0.022274131,
0.016618693,
0.016190859,
-0.032863032,
0.0154020395,
0.027087267,
-0.0028711702,
-0.023584373,
-0.035724174,
0.0037669486,
0.0007507993,
-0.020469204,
0.015148013,
-0.008168964,
-0.00033696138,
0.030135589,
-0.032408457,
0.019827452,
-0.009004578,
0.00848984,
0.028691646,
0.0053211907,
-0.008656963,
-0.01385114,
-0.034333713,
-0.012494102,
0.00046460144,
0.010916463,
-0.01189246,
0.01463996,
-0.00015855778,
-0.034012835,
-0.0061768596,
0.0016946255,
0.033397824,
0.013583743,
0.0111370655,
0.006260421,
0.006216969,
-0.020215176,
0.014399302,
0.0015768039,
0.011150435,
-0.014720178,
-0.010294766,
0.010154383,
0.013336401,
0.0053412453,
0.015228231,
0.020041369,
-0.0035496887,
0.013958098,
0.010829559,
-0.00072447746,
-0.02307632,
0.005608642,
-0.011431201,
0.034306973,
0.010134328,
-0.007841403,
-0.009666384,
-0.024948096,
0.020375615,
-0.022955991,
-0.00022645143,
-0.014024948,
-0.008550004,
0.009405673,
-0.031953882,
0.014680069,
0.024292974,
-0.013536949,
-0.014960836,
-0.0131893335,
-0.0017748444,
-0.025683437,
0.024038946,
-0.03393262,
-0.0041613583,
-0.020602902,
0.0067317076,
-0.0043284814,
0.0077946084,
0.024252864,
0.021311503,
0.0061200378,
-0.011244023,
-0.003726839,
-0.03922707,
0.024186015,
0.012306925,
0.0037435512,
-0.0016929542,
0.00021391721,
-0.0029447041,
0.0061200378,
-0.00025883148,
-0.0069589945,
0.011003367,
0.01612401,
-0.01302221,
-0.027835978,
-0.012708019,
0.02839751,
0.0032588951,
0.011872405,
0.009646329,
0.008015211,
0.014867246,
-0.010074164,
-0.00027512596,
-0.0039407564,
-0.007848088,
0.00963296,
-0.02155216,
0.05315843,
0.015816504,
-0.010582217,
-0.009519316,
0.010207863,
-0.024774287,
-0.12449982,
-0.031793445,
-0.0124005135,
0.026271708,
-0.020910408,
-0.0044187275,
0.023718072,
0.03623223,
-0.04756984,
0.028156854,
0.013730811,
0.0032822923,
-0.005886066,
0.006574612,
0.005615327,
-0.023637852,
0.038344663,
-0.005301136,
-0.006440914,
0.013891249,
-0.0067551048,
-0.0075405817,
0.0052543418,
0.0033391141,
0.0037502362,
0.006019764,
-0.032969993,
0.0399223,
0.00021182818,
-0.0006104161,
0.020856928,
-0.00653116,
0.013396566,
-0.01228687,
-0.0076475404,
-0.013958098,
0.007440308,
0.0032789498,
0.055671956,
-0.025081793,
0.018931674,
-0.0008949427,
0.01695294,
0.0013486812,
0.01681924,
0.003566401,
0.01922581,
0.033290867,
-0.0052977935,
-0.016739022,
-0.032889772,
0.00296643,
-0.022488046,
0.0049234387,
0.021699227,
-0.019372879,
0.0153753,
0.009151646,
-0.023129798,
0.0041346187,
0.004325139,
0.0066682007,
-0.02613801,
-0.005989682,
0.015629327,
-0.016297817,
-0.02536256,
-0.013917989,
0.010949887,
-0.027167486,
0.018824715,
-0.00013850305,
0.0034761548,
0.00842299,
-0.03000189,
0.025014944,
0.008215758,
0.00075999106,
-0.019145591,
-0.016244339,
-0.010615642,
-0.012186596,
-0.0045557683,
-0.040617533,
-0.016337927,
0.005966285,
0.0130355805,
-0.002812677,
-0.00074077194,
-0.011384407,
-0.035216123,
0.025095163,
0.0088174,
-0.010969942,
-0.03235498,
0.0011640105,
-0.0053713275,
0.0035129217,
0.044120427,
0.02066975,
-0.016779132,
-0.023597743,
-0.04297062,
0.007086008,
0.006093298,
-0.015254972,
0.012968731,
0.0005552656,
0.022274131,
0.012982101,
-0.013329716,
0.006260421,
-0.024359822,
0.008550004,
-0.023450674,
-0.020121587,
-0.00670831,
-0.0060297917,
0.024386562,
-0.022915881,
0.0092318645,
0.022675226,
0.014787028,
-0.015709545,
0.018931674,
0.018878194,
-0.029841451,
-0.019332768,
-0.028531209,
0.0065010777,
-0.0078213485,
0.023303607,
0.0101944925,
-0.023664592,
0.0021809528,
0.011350982,
-0.008242498,
0.0033157167,
0.0044087,
0.00006246215,
0.010769395,
-0.0021809528,
-0.013931358,
-0.02152542,
0.02066975,
-0.040243175,
-0.012500787,
0.00220435,
-0.035777654,
0.01907874,
-0.003324073,
0.0025151984,
0.035135902,
0.0028945673,
0.005929518,
-0.035670694,
-0.009953835,
0.002336377,
-0.0050237123,
-0.03152605,
-0.0036700172,
-0.0014798726,
0.044949356,
-0.00653116,
0.053345606,
-0.005000315,
-0.012360404,
-0.0016879406,
-0.023464045,
0.0010503669,
0.017621431,
-0.014666699,
-0.013744181,
-0.0068420083,
0.04128602,
-0.021605639,
0.012982101,
-0.0049033836,
-0.018330032,
0.002964759,
-0.010842929,
0.01541541,
0.019412987,
0.017086638,
-0.005053794,
0.022902511,
0.01998789,
0.025683437,
-0.016204229,
-0.007045898,
0.03369196,
0.008944414,
0.010020684,
0.019506576,
0.0153753,
-0.008770606,
0.018851455,
0.036045052,
-0.0075405817,
-0.01039504,
-0.013496839,
0.0076475404,
0.001881803,
0.017447622,
0.0041045365,
-0.017982416,
-0.0013060649,
0.027408144,
-0.034413934,
-0.027220966,
-0.01697968,
0.02458711,
0.005090561,
-0.009653014,
0.011691913,
0.0008001005,
0.0053345608,
0.01768828,
0.005632039,
-0.0022862402,
-0.019386247,
0.0119191995,
0.009900356,
0.015803134,
-0.011685228,
-0.00080971007,
0.023677962,
-0.007948361,
0.03305021,
-0.042890403,
0.03933403,
-0.017969046,
0.023423934,
0.0010035726,
-0.034200016,
-0.014880616,
0.009753288,
-0.0048365346,
0.0035530312,
0.009158331,
-0.02683324,
0.07765195,
0.030429725,
-0.008282607,
0.0038471674,
-0.01461322,
0.035536997,
0.0057523674,
0.004188098,
0.03219454,
-0.01835677,
0.008509894,
-0.01534856,
0.027100638,
-0.024292974,
-0.008275922,
0.02074997,
-0.0125542665,
0.006795214,
0.02464059,
-0.028076634,
0.010301451,
-0.02224739,
0.0017748444,
0.009452467,
-0.024212755,
-0.020963887,
0.013269552,
-0.004512316,
-0.012320295,
-0.015963573,
0.03227476,
-0.0058225594,
-0.03227476,
0.005785792,
-0.010374985,
-0.006297188,
-0.0070993775,
-0.04537719,
-0.011457941,
0.015642697,
0.0065980093,
-0.0037168115,
-0.013042266,
-0.02390525,
0.009947151,
0.010074164,
0.008910989,
-0.0015910093,
-0.009325454
] |
FoxO transcription factors, inhibited by insulin/insulin-like growth factor signalling (IIS), are crucial players in numerous organismal processes including lifespan. Using genomic tools, we uncover over 700 direct dFOXO targets in adult female Drosophila. dFOXO is directly required for transcription of several IIS components and interacting pathways, such as TOR, in the wild-type fly. The genomic locations occupied by dFOXO in adults are different from those observed in larvae or cultured cells. These locations remain unchanged upon activation by stresses or reduced IIS, but the binding is increased and additional targets activated upon genetic reduction in IIS | [
-0.029841816,
-0.031383067,
-0.010104497,
-0.03709633,
-0.030160695,
-0.002509516,
-0.039753657,
0.015651673,
-0.009812191,
-0.026028547,
0.02681246,
0.0019215818,
0.017378937,
0.006297872,
-0.0142167155,
0.009340515,
0.018853756,
-0.00827094,
0.02133836,
-0.010157644,
-0.014788042,
0.013313224,
-0.0052847653,
-0.01971739,
-0.0009898554,
0.017870544,
-0.0013311562,
-0.042331267,
-0.010476524,
-0.022799892,
0.015678247,
0.0018717569,
-0.0126356045,
0.009426878,
0.000106500804,
-0.010283867,
-0.007068498,
-0.023411078,
-0.012143998,
-0.0016874046,
0.016874045,
0.014907622,
-0.0024231528,
0.025510369,
0.0077394736,
0.013060777,
0.017392226,
-0.011061137,
0.007208008,
0.02153766,
-0.007925487,
0.01725936,
-0.0212985,
-0.019531375,
-0.006161684,
0.0031705268,
0.035714515,
-0.001664153,
0.00777269,
0.0010014812,
-0.0037866952,
0.0027320674,
-0.029204058,
0.017657958,
-0.015279648,
0.017060058,
0.0036571505,
0.018309005,
0.012376514,
0.008064996,
0.050542418,
0.02471317,
-0.0023766495,
0.017033486,
0.010038064,
-0.021511087,
-0.021590807,
0.004321483,
0.026201274,
0.0022188707,
0.027689379,
-0.0137915425,
-0.0076730405,
0.026599873,
0.025483795,
0.00045465256,
-0.020102702,
0.027397072,
-0.017232785,
0.02261388,
-0.0063045155,
0.015837686,
0.03784038,
0.028566297,
-0.012296795,
-0.012801687,
-0.013074064,
0.011340156,
-0.0135523835,
-0.03260544,
-0.011997845,
0.0022803214,
-0.0025709667,
-0.015266361,
-0.011034563,
-0.00021061416,
0.00091760926,
-0.00043181612,
0.0023367896,
-0.017963551,
-0.011678966,
0.045094892,
-0.00028462496,
-0.05040955,
0.016927192,
-0.02367681,
0.031755093,
0.012449591,
-0.03172852,
0.006321124,
0.03356208,
0.027237633,
0.004607146,
-0.01899991,
-0.016927192,
0.007095071,
0.019584522,
0.008809049,
-0.020634167,
-0.0051286467,
0.010655893,
-0.020514587,
0.026187988,
-0.0054275966,
-0.030346708,
0.010635964,
-0.02978867,
0.0008283396,
0.011632462,
-0.02994811,
0.00085117604,
0.017564952,
-0.034438998,
0.0016450534,
0.001234828,
0.00321703,
0.012496094,
0.0034379207,
0.026706167,
0.0029147589,
0.0051286467,
-0.017564952,
0.041188616,
-0.011878265,
0.03768094,
0.03866415,
0.028885178,
0.042969026,
0.018016698,
-0.008530029,
-0.002707155,
-0.009998204,
-0.0017438729,
0.009068139,
0.009838765,
0.0082510095,
0.013020917,
-0.00023293159,
0.0043546995,
0.008888769,
0.010117784,
0.023052339,
-0.03510333,
0.04445713,
0.0066300384,
0.023118772,
0.010104497,
0.009945057,
-0.007878983,
0.011898195,
-0.014243289,
0.015160068,
0.011745399,
0.0074471673,
-0.025696382,
0.012243648,
-0.00051651854,
-0.015571954,
-0.0017305862,
-0.020554448,
0.0064407038,
0.011818475,
0.01118736,
-0.017006911,
-0.6369089,
-0.00029147588,
0.0074870274,
-0.022534158,
0.008875483,
0.037893526,
-0.01606356,
-0.0071017146,
-0.023849538,
0.02411527,
-0.0036538288,
0.004391238,
0.01725936,
-0.016993625,
-0.025125055,
-0.039992817,
-0.0069754915,
-0.012648891,
0.021112487,
0.0068758414,
0.0020245533,
-0.004753299,
-0.0028283957,
0.011745399,
0.016595026,
0.028220845,
0.030612443,
-0.033641797,
0.01031044,
0.014841188,
-0.004932669,
0.039673936,
-0.0051220036,
0.022481011,
0.05468785,
-0.008403806,
-0.017604811,
0.024088698,
0.020288715,
0.059949365,
-0.04076344,
0.020780321,
0.03287117,
0.0052415836,
-0.027742526,
0.0086761825,
0.0017322471,
0.010044708,
0.023464223,
-0.013818116,
-0.010363587,
-0.0014274844,
-0.021803392,
-0.025231348,
0.0020345184,
0.015186641,
0.012343298,
-0.021152347,
0.017591525,
0.003949457,
-0.010542957,
0.02141808,
-0.020541161,
0.004201903,
0.0022985905,
-0.0041553997,
-0.0055438546,
0.004122183,
0.027503366,
-0.009533172,
0.02193626,
0.030479575,
-0.0121506415,
0.021019481,
0.021165634,
0.026905466,
-0.0051884367,
0.019823682,
-0.010137714,
0.02752994,
0.0052781217,
0.0024630127,
-0.01780411,
0.015226501,
0.026307568,
-0.021670526,
-0.0018933476,
0.010702397,
-0.016913906,
-0.028141124,
0.018694317,
-0.008589819,
-0.01923907,
-0.031170482,
-0.0062081874,
0.012442948,
-0.009061496,
0.016289433,
0.026998473,
-0.023504084,
-0.00013971743,
0.0062447255,
-0.009573031,
-0.0022554088,
0.027742526,
0.0030276955,
-0.02681246,
0.018269144,
0.019265642,
-0.028778885,
-0.00807164,
0.0025759493,
-0.022839751,
-0.009207648,
-0.003819912,
-0.022268426,
0.022680312,
-0.03236628,
0.008443667,
-0.016090134,
0.016369153,
0.0024131879,
0.013160427,
-0.010456594,
0.015319508,
0.007513601,
0.00777269,
-0.0035475355,
0.0034711373,
-0.0076265372,
0.011931412,
0.000065187625,
0.009878624,
-0.032073975,
0.00014459612,
0.012535955,
0.019464942,
0.0045838943,
0.036219407,
-0.028114552,
-0.045918662,
0.0050456054,
0.010582817,
-0.022215279,
0.00073035056,
-0.017936978,
-0.0049492773,
0.005699973,
0.02343765,
-0.013937696,
0.0028516473,
-0.017511806,
-0.016209712,
0.02026214,
0.0067595835,
-0.021949546,
-0.005048927,
-0.019956548,
-0.0052548703,
-0.005995601,
-0.0024148487,
0.019225784,
-0.011911482,
-0.01848173,
-0.026187988,
-0.013871263,
0.0049459557,
0.024048837,
-0.015319508,
-0.03228656,
0.00065187627,
-0.019650955,
-0.009466738,
0.008144717,
0.0140971355,
0.001013107,
0.0033316275,
0.010051351,
-0.0027918573,
-0.014708322,
-0.0052980515,
-0.012462878,
-0.031542506,
-0.018627884,
0.019690815,
0.007839124,
0.009911841,
0.03260544,
-0.00060371216,
0.025536941,
-0.00821115,
0.004759942,
-0.0017073345,
0.018388724,
0.00801185,
-0.032738306,
0.02459359,
-0.0046436843,
-0.0072412244,
0.016794326,
0.032711733,
-0.04631726,
0.01646216,
-0.021922972,
0.006799443,
-0.020567734,
0.019624382,
-0.02435443,
-0.009951701,
0.00535452,
0.012595744,
0.017219499,
-0.0081115,
-0.002863273,
0.025510369,
0.0068625547,
-0.0015645031,
-0.00022545784,
-0.005580393,
-0.022454439,
-0.012104139,
-0.011791902,
0.020634167,
-0.0023085554,
0.0011858335,
0.01919921,
0.012954484,
0.00034690613,
0.024766317,
-0.0041321483,
-0.017511806,
-0.009380375,
-0.002815109,
0.009978274,
0.004793159,
0.0035408922,
0.0067961216,
-0.025802674,
0.04169351,
-0.014894335,
0.016382439,
-0.013977556,
0.045785796,
0.0065270667,
-0.0032967501,
-0.022587305,
0.036936887,
-0.006626717,
-0.035741087,
0.004833019,
-0.004567286,
0.014947481,
-0.0065303887,
0.009167789,
0.009526528,
0.0068957713,
0.0072478675,
0.0025344286,
0.028486578,
0.02693204,
0.025350928,
-0.0016716267,
0.0021441332,
-0.010330371,
0.002569306,
0.024660023,
-0.0031954395,
-0.00015103184,
-0.0051319688,
-0.009818834,
-0.038823593,
0.02343765,
0.015239787,
-0.01310728,
0.028592872,
0.009566388,
0.00431484,
0.013293293,
0.017578239,
0.013020917,
0.007400664,
-0.027397072,
0.02808798,
0.013512523,
-0.0018385402,
-0.014243289,
-0.017432084,
0.0050821435,
0.024925755,
0.012376514,
0.018428585,
-0.00021445483,
0.002076039,
0.0058228746,
-0.0071017146,
0.006457312,
0.022999192,
-0.044483706,
-0.011466379,
-0.014429302,
0.021962833,
0.010051351,
0.0029097763,
-0.00793213,
0.048575994,
-0.011612533,
0.01106778,
-0.004789837,
0.011034563,
-0.008304156,
-0.008549959,
-0.014203429,
0.0033615225,
-0.023331357,
0.0003390172,
0.0024879253,
-0.015385941,
-0.0027038334,
0.015478947,
-0.0054774215,
-0.019451655,
-0.01876075,
-0.0152530745,
-0.015850974,
0.037973247,
0.022574019,
-0.016090134,
0.00823108,
-0.010111141,
-0.006062034,
-0.034173265,
-0.011100996,
0.009400305,
-0.0119646285,
-0.005288087,
0.0011110961,
-0.0030592512,
-0.010157644,
0.0073275873,
0.0025228027,
-0.01112757,
-0.034731302,
-0.023304785,
-0.008716042,
-0.017365651,
0.0060088877,
0.013499237,
0.039328486,
0.052615136,
-0.010210791,
-0.00661343,
0.049027737,
-0.0062081874,
-0.01828243,
-0.0017372295,
0.01322686,
0.015797827,
0.015186641,
0.0004129242,
-0.022414578,
0.0038033037,
0.009945057,
0.008224436,
0.023703383,
0.007380734,
0.010416734,
0.018933477,
0.0074338806,
0.005600323,
-0.034731302,
-0.024062123,
0.026626447,
-0.032658584,
-0.031170482,
0.021710386,
-0.023849538,
-0.026506867,
-0.014681748,
0.003050947,
-0.012084208,
0.009818834,
0.0067197233,
-0.010124427,
-0.021909686,
-0.0024414218,
-0.0126356045,
0.019797109,
-0.008755903,
0.007759404,
0.0042384416,
0.008696113,
-0.012569171,
-0.021670526,
-0.0036106473,
0.02931035,
-0.017618097,
-0.01872089,
-0.0029313671,
0.005680043,
0.023743244,
0.020275429,
-0.018627884,
0.031622227,
0.008696113,
-0.01314714,
-0.011453092,
0.0065503186,
-0.019451655,
0.009705898,
0.0002759056,
0.007068498,
-0.007214651,
-0.011971272,
0.005866056,
0.013419516,
0.002451387,
-0.001190816,
-0.00637427,
-0.007726187,
0.009074782,
0.025722954,
0.036219407,
0.0067728697,
-0.008735972,
-0.0028998114,
-0.016820898,
-0.0375215,
-0.021736959,
-0.019225784,
-0.022122273,
0.010542957,
-0.0008744277,
-0.01828243,
-0.021763533,
0.012203788,
-0.0006020513,
0.0071150013,
0.0007702105,
0.019491516,
0.014535596,
0.0045539993,
0.029363496,
-0.008755903,
-0.0022487654,
-0.004251728,
-0.022268426,
0.015226501,
0.024739742,
-0.012788401,
0.012330011,
0.0027436933,
-0.012821618,
-0.0363257,
0.019345362,
0.0043347697,
0.032472573,
0.0013062438,
-0.032020826,
-0.02002298,
0.0052017234,
-0.027636232,
-0.0025825927,
-0.0051817936,
-0.005690008,
-0.019983122,
0.006101894,
0.02705162,
-0.034199838,
0.038531285,
-0.032313135,
-0.008377233,
0.010934913,
0.028406858,
0.006337732,
0.0025975402,
0.011120927,
-0.0065403534,
-0.0042949095,
-0.015890833,
-0.03914247,
0.006321124,
-0.026560014,
0.03292432,
0.014416016,
0.027423646,
0.019943262,
-0.009373732,
0.022029266,
0.0033648442,
0.010416734,
-0.0024430829,
0.01880061,
-0.012343298,
-0.00022649586,
0.008749259,
0.0005846126,
0.020302001,
-0.017976837,
0.007234581,
0.015053774,
-0.030825028,
-0.011074423,
0.0049559204,
-0.024766317,
-0.019398509,
-0.007586677,
-0.011532812,
-0.0071681477,
-0.031143907,
-0.0013311562,
0.028566297,
0.011639105,
0.022268426,
0.00029002267,
0.026639733,
-0.033057187,
0.02705162,
0.0085101,
0.0038066253,
-0.027981685,
-0.006145076,
0.0015661638,
-0.0045141396,
0.026905466,
-0.022454439,
0.00829087,
0.004328126,
-0.007440524,
-0.0032552292,
0.006723045,
-0.016874045,
-0.0039594215,
-0.017060058,
-0.03260544,
0.0056335395,
-0.023597091,
-0.0154258,
-0.030639015,
0.0010571191,
0.015492234,
-0.021524373,
0.026134841,
0.009174432,
-0.020953048,
0.02403555,
-0.012529311,
0.022241853,
-0.021019481,
0.030692162,
0.020554448,
0.019890115,
-0.011047849,
-0.02641386,
0.0068359813,
-0.004879522,
0.022467725,
0.035050184,
-0.010483167,
-0.02026214,
-0.0011484649,
-0.0070817843,
-0.022534158,
-0.022082413,
-0.00019608189,
-0.0044377414,
0.010988059,
-0.0074338806,
0.002379971,
-0.009938414,
-0.0056069666,
-0.013419516,
-0.008815693,
0.006158362,
-0.009380375,
-0.0038763802,
0.011413232,
-0.003710297,
0.005580393,
0.00509543,
0.0045706076,
-0.0034877458,
-0.034837596,
0.0031190412,
-0.0077394736,
-0.0077992636,
0.035873957,
0.0050522485,
0.02153766,
0.0067363316,
0.016395727,
-0.00089934014,
-0.0060088877,
-0.0086163925,
0.03744178,
-0.00013162088,
-0.009433522,
0.00007245377,
-0.00069754914,
-0.006380914,
0.004686866,
0.010596103,
0.0005459983,
-0.010224077,
-0.013658676,
0.0140971355,
-0.0007689649,
0.0016035326,
0.0013394604,
-0.019092916,
-0.02014256,
-0.015997127,
-0.042278122,
0.027901966,
-0.043261334,
0.011034563,
0.0062812637,
0.034731302,
0.021643953,
0.024606876,
-0.0038232335,
0.0074737407,
0.024101984,
-0.0214978,
0.009400305,
0.008696113,
-0.01064925,
-0.008941916,
0.015532094,
-0.0023783103,
-0.03744178,
0.014455875,
-0.009951701,
-0.0112936525,
0.0049193823,
0.011499596,
0.00050738396,
0.027583085,
-0.009234222,
0.008802406,
0.011931412,
0.0019082951,
-0.011240506,
-0.0051286467,
0.019637669,
-0.014920908,
0.007580034,
0.0055870363,
0.0023882755,
-0.011732112,
-0.004397881,
0.012436304,
0.016475447,
0.007194721,
-0.0055571413,
-0.014854475,
0.0036372205,
-0.0067197233,
0.0032834634,
-0.01852159,
-0.013618817,
-0.032419425,
0.021869825,
-0.022042552,
0.014721609,
-0.038212407,
0.0070020645,
-0.005311338,
0.004401203,
-0.0111142825,
-0.0055538197,
-0.0015769593,
-0.028380284,
-0.051817935,
0.0036206122,
-0.0041886163,
0.021085914,
0.0130009875,
-0.029841816,
-0.0090415655,
-0.010901696,
-0.03709633,
-0.02145794,
0.0039295265,
0.021325074,
-0.012469521,
0.004530748,
-0.00019327924,
0.009533172,
-0.008948559,
0.032897744,
-0.021112487,
-0.036431994,
-0.0023002513,
0.022534158,
0.02327821,
-0.0030658946,
-0.028141124,
-0.009360445,
0.016382439,
-0.013698536,
-0.01594398,
0.0050157104,
-0.030692162,
0.028220845,
-0.025231348,
-0.011074423,
-0.009154502,
0.012795044,
0.014615315,
-0.019225784,
-0.009141215,
0.019252356,
-0.0051319688,
-0.0066997935,
-0.015359367,
-0.020554448,
0.014641888,
0.010057994,
-0.0017754287,
-0.02673274,
0.022029266,
0.004793159,
0.007998563,
0.009433522,
0.02891175,
0.012974414,
0.010536314,
-0.0036471854,
-0.02561666,
0.0021374898,
-0.020567734,
-0.0065901782,
0.0007349178,
-0.0051319688,
-0.009300655,
-0.015877547,
-0.0034877458,
-0.0320474,
0.010051351,
-0.0026390608,
-0.0034213124,
-0.0363257,
0.011506239,
-0.01713978,
-0.0017272645,
-0.014057276,
0.020115988,
0.015718106,
-0.025988687,
0.008895412,
-0.0034047042,
0.0039760303,
-0.013193644,
0.0056933295,
-0.011592602,
-0.007075141,
-0.027397072,
-0.01066918,
-0.0046702577,
0.025218062,
0.19345362,
-0.018694317,
0.00529473,
0.011253793,
0.015518808,
0.011864979,
0.037468355,
-0.021524373,
-0.006576892,
-0.0033880959,
0.0027237632,
-0.0052415836,
0.0017538378,
-0.0022072447,
0.019783823,
-0.024101984,
-0.0020826824,
0.0057531195,
-0.011499596,
-0.007832481,
0.023504084,
-0.012217075,
-0.00027486758,
-0.0064739203,
0.050223537,
0.0032303168,
-0.024022263,
0.0072212946,
-0.0023102162,
0.029363496,
-0.0024829428,
0.009539815,
0.0026457042,
0.032259986,
0.005460813,
-0.010456594,
-0.01058946,
-0.011526169,
0.014628602,
-0.019185923,
0.01598384,
-0.0009101355,
-0.00797199,
-0.011413232,
0.0060055656,
0.0019846933,
0.014588742,
-0.0078856265,
-0.01923907,
0.0047200825,
-0.051631924,
0.011074423,
-0.003130667,
0.036352273,
-0.0020411615,
0.0063410536,
0.011134213,
-0.0016716267,
-0.0015761289,
0.002223853,
-0.0033964,
0.011572672,
-0.019571235,
0.016807612,
-0.017551664,
0.04525433,
-0.015213215,
0.011353442,
0.016927192,
-0.0144027285,
-0.015080348,
0.004331448,
-0.017272646,
0.010237364,
0.006546997,
-0.0152530745,
0.022082413,
0.007639824,
0.027583085,
0.028433431,
0.0023849537,
0.004397881,
-0.014535596,
0.0018136278,
0.0057730493,
-0.027476793,
0.03518305,
-0.0074670976,
-0.031595655,
-0.027689379,
0.01102792,
-0.014336295,
-0.0077926205,
-0.018734178,
-0.0030858244,
-0.01931879,
-0.008224436,
0.032233413,
-0.007839124,
-0.006161684,
-0.031170482,
0.07328916,
-0.008204507,
0.024381002,
0.0035276057,
0.0048263757,
-0.009759044,
0.013054133,
-0.007314301,
-0.01844187,
0.01725936,
-0.029204058,
-0.01274854,
-0.013479306,
-0.005371128,
0.005699973,
0.026825747,
-0.010463237,
0.0115394555,
0.0015022219,
0.0017471944,
-0.016395727,
0.004165365,
0.033376064,
-0.0271712,
-0.0259754,
-0.03308376,
-0.010795403,
-0.026878893,
-0.031276774,
-0.0015528772,
-0.027689379,
-0.0049658855,
0.010961486,
0.0073873773,
-0.025218062,
0.019146062,
-0.006301194,
-0.0218964,
0.024327856,
-0.021444654,
-0.008383877,
0.0047499775,
0.015186641,
0.008344016,
-0.022746745,
0.014123709,
0.0111142825,
0.01031044,
0.012143998,
-0.01923907,
-0.0109482,
-0.0077527603,
0.0152530745,
0.030160695,
-0.00845031,
-0.0016060239,
-0.038611006,
0.0049160607,
0.0055073164,
-0.04004596,
0.0054043448,
-0.017365651,
-0.017870544,
-0.01404399,
-0.0020428225,
-0.16783696,
0.0047964808,
0.008383877,
-0.021046054,
0.03382781,
-0.0035840739,
0.015585241,
-0.03218027,
0.0058893077,
0.016568452,
0.012702038,
0.0069223447,
-0.042278122,
-0.021604093,
0.0020527875,
0.0151334945,
-0.010004847,
0.0387173,
0.0100181345,
0.0036837237,
0.018973336,
-0.0006718062,
0.0158244,
-0.017737677,
-0.012369871,
0.0210992,
0.023450937,
-0.029204058,
0.013319867,
-0.03260544,
-0.027118053,
0.0035109974,
0.0024713168,
-0.019278929,
0.003906275,
-0.017365651,
-0.022786604,
-0.010104497,
-0.015505521,
0.033641797,
0.019797109,
0.022388006,
-0.015160068,
0.009181075,
-0.00845031,
0.015917407,
-0.0018617918,
0.011373373,
0.008503456,
0.0055438546,
0.033136904,
-0.0064905286,
0.0005061383,
0.010988059,
0.0064539905,
-0.011154143,
0.009014992,
0.022866325,
-0.004045785,
-0.01350588,
-0.002401562,
-0.014416016,
0.04177323,
0.004172008,
0.015173354,
-0.017737677,
-0.020527875,
0.034970462,
-0.03287117,
0.0011941377,
-0.005856091,
-0.006822695,
0.013964269,
0.000657274,
0.014920908,
0.00021694608,
-0.009553102,
0.009247509,
0.021790106,
0.010270581,
-0.0065270667,
0.002992818,
-0.034492142,
-0.0102639375,
0.0015910764,
0.0077992636,
0.0151334945,
0.033854384,
-0.0020361792,
0.015053774,
0.01618314,
-0.008749259,
-0.0025344286,
-0.005942454,
0.011446449,
0.01586426,
0.004922704,
0.0023334678,
-0.0013178696,
0.012907981,
0.014256575,
-0.0164223,
0.0030542687,
-0.0033000717,
0.026746027,
0.012848191,
-0.029602656,
0.01654188,
0.052296255,
0.0052415836,
0.009307299,
0.010914983,
-0.00065644353,
0.0077195438,
-0.013100637,
0.011473022,
0.005068857,
-0.0064440253,
0.009546458,
-0.024567015,
0.06563605,
0.0131803565,
-0.0015728072,
0.02443415,
-0.016236287,
-0.027662806,
-0.12372529,
-0.025417361,
0.0216971,
0.022760032,
-0.020594308,
0.007394021,
0.004032498,
0.026400574,
-0.02383625,
0.013964269,
-0.009440165,
-0.013379657,
0.0013967591,
-0.0011791902,
0.0035840739,
-0.00064564816,
0.02141808,
0.0028383606,
-0.0021989406,
0.05120675,
-0.002962923,
-0.010582817,
-0.00048164107,
0.0025244635,
-0.0006684846,
-0.00095996045,
-0.020448154,
0.0014847831,
-0.0022039232,
0.015505521,
0.014602029,
-0.0018833827,
0.034811024,
-0.0035641438,
-0.023942543,
-0.012356585,
0.014323009,
-0.030107548,
0.039009605,
-0.015186641,
-0.000511536,
-0.00094750425,
0.0053810934,
-0.0048363404,
-0.004759942,
-0.012735254,
0.01320693,
-0.005444205,
0.02459359,
-0.008370589,
-0.03608654,
-0.025882395,
-0.04081659,
-0.023504084,
0.024899183,
-0.00020469746,
0.025311068,
0.004969207,
-0.0007274441,
0.001662492,
0.027476793,
0.0051585417,
-0.033004038,
0.019425083,
0.0012447931,
-0.018375438,
-0.022932759,
-0.040391415,
0.014774755,
-0.027104767,
-0.01316707,
0.012077565,
-0.0027785706,
-0.002125864,
-0.031117335,
-0.0011418215,
-0.0013917766,
-0.015797827,
-0.0052914084,
-0.0320474,
0.005925846,
-0.022534158,
0.011526169,
-0.030001257,
0.008058353,
0.007234581,
0.024008976,
-0.015385941,
-0.010057994,
-0.0061683273,
-0.008762546,
0.015000628,
-0.0045805727,
-0.0054342397,
-0.02495233,
0.0015561989,
0.012017775,
-0.020155849,
0.013778256,
0.004746656,
-0.022653738,
-0.01007128,
-0.054953586,
-0.0021109167,
0.0045706076,
0.0023749887,
-0.00657357,
-0.023703383,
-0.010954843,
0.0016301059,
-0.009586318,
0.00075816945,
-0.020554448,
0.0053877365,
-0.018255858,
-0.008961845,
-0.015904121,
-0.019797109,
0.019969836,
-0.0273705,
0.022574019,
0.032100547,
0.015080348,
-0.0007623216,
0.009048209,
-0.017299218,
-0.0015686551,
-0.00805171,
-0.01376497,
0.012024418,
-0.010602747,
-0.014734895,
-0.00521501,
-0.040364843,
-0.0154390875,
0.011692252,
-0.016382439,
-0.023211777,
-0.013831403,
0.022401292,
0.006643325,
0.02954951,
-0.0015769593,
-0.029682375,
0.016090134,
-0.014801328,
0.0067662266,
-0.0080052065,
-0.01959781,
-0.0006722215,
0.0013809812,
-0.0030991111,
0.011785259,
0.006404165,
-0.01935865,
-0.011160786,
-0.00007624253,
-0.012143998,
0.015306221,
-0.012562527,
-0.015890833,
-0.0031705268,
0.012894694,
0.012954484,
-0.006181614,
-0.008523386,
0.018003412,
-0.03704318,
-0.04097603,
-0.020647455,
0.0061849356,
-0.026134841,
-0.034917317,
0.015319508,
0.013658676,
0.0009342176,
0.02153766,
0.0132467905,
-0.018056558,
-0.011898195,
-0.018096417,
0.039248765,
0.023225065,
-0.00862968,
-0.014203429,
0.026227847,
0.026387287,
0.014110423,
-0.021019481,
0.012442948,
-0.0023783103,
0.009406948,
-0.021245353,
0.010064637,
0.0042650145,
0.0025344286,
0.020581022,
0.01610342,
-0.015027202,
0.01594398,
-0.021192206,
0.014655175,
0.0032967501,
-0.0068559116,
0.0070419246,
-0.01931879,
-0.016475447,
0.016874045,
-0.000007824072,
-0.044908877,
-0.005371128,
0.0036073255,
-0.012403088,
0.010802046,
0.0072279377,
0.0036471854,
-0.017737677,
0.004663614,
-0.0074737407,
-0.00637427,
-0.0112936525,
0.029496362,
0.01935865,
-0.0012489451,
0.002183993,
-0.016395727,
-0.004793159,
-0.009606248,
0.03818583,
-0.024620162,
0.014655175,
-0.011386659,
0.019783823,
0.01380483,
-0.021723673,
-0.017883832,
0.007699614,
-0.00787234,
0.0023484153,
-0.0019813718,
-0.006746297,
0.08354646,
0.016196426,
-0.04307532,
-0.02689218,
-0.020966334,
0.013844689,
-0.017843971,
0.017365651,
-0.029071191,
-0.027636232,
0.019903403,
-0.039753657,
0.01292791,
-0.03427956,
-0.020660741,
0.008775832,
-0.014163569,
-0.00023064794,
-0.0016176497,
-0.012848191,
-0.009533172,
-0.015492234,
0.00034316926,
0.017312504,
-0.04169351,
0.003829877,
0.041985814,
0.0074670976,
-0.0026606517,
-0.02784882,
0.0051618638,
-0.0007602455,
-0.021869825,
0.009014992,
0.020926474,
0.01380483,
0.007686327,
-0.009074782,
0.032977466,
0.027064906,
-0.0067562615,
-0.014243289,
-0.00043140093,
-0.00261747,
0.0064838855,
0.018827183,
0.0032037436,
0.0064307386,
-0.028114552
] |
OBJECTIVES To explore the association between a stable partnership and clinical outcome in HIV infected patients receiving highly active antiretroviral therapy (HAART). DESIGN Prospective cohort study of adults with HIV (Swiss HIV cohort study). SETTING Seven outpatient clinics throughout Switzerland. PARTICIPANTS The 3736 patients in the cohort who started HAART before 2002 (median age 36 years, 29% female, median follow up 3.6 years). MAIN OUTCOME MEASURES Time to AIDS or death (primary endpoint), death alone, increases in CD4 cell count of at least 50 and 100 above baseline | [
-0.004784871,
-0.0110849505,
0.020893935,
-0.03862454,
0.0058880495,
0.026197167,
0.024030685,
0.027326928,
-0.019152775,
-0.010679566,
-0.0015326539,
0.01687996,
-0.0041203056,
0.0014545675,
-0.0074032587,
0.018567957,
0.03790681,
-0.019963544,
-0.00057152624,
-0.015098926,
-0.034716897,
-0.015590704,
-0.010752668,
-0.01260016,
0.014926138,
-0.010307409,
0.023033837,
-0.01726541,
-0.013955873,
-0.019498348,
0.0030370639,
-0.003057001,
-0.022834467,
-0.019644553,
-0.0181958,
-0.0197243,
-0.0022694909,
0.009696009,
0.027459841,
-0.0022395854,
-0.0015534216,
-0.011490336,
-0.00023052112,
0.012274523,
0.0011904028,
0.0017511299,
0.015298296,
-0.015471082,
-0.0136368815,
0.02886872,
0.010586527,
0.01178939,
-0.016893253,
-0.0064230245,
0.01493943,
-0.024788288,
-0.009317207,
0.022209775,
-0.025984507,
-0.01402233,
-0.014155243,
-0.009197585,
-0.037640985,
0.018169219,
-0.022900924,
0.0013241465,
-0.01331789,
0.021359133,
0.0181958,
0.042213194,
0.018979987,
0.014181825,
-0.015231838,
0.012374207,
0.023871189,
-0.0033294726,
-0.031154826,
-0.0027230566,
0.008287131,
0.026901606,
0.023219915,
-0.013131812,
0.0029556546,
0.020761022,
0.008081115,
-0.0014728431,
0.005143736,
0.01848821,
0.009782403,
0.009443474,
0.0007360062,
0.002588482,
-0.0076557933,
0.028204156,
-0.0027861905,
0.018275548,
-0.0034989368,
0.023180041,
0.0032364335,
-0.0070377477,
-0.011902366,
-0.018740743,
-0.017424904,
-0.012912505,
-0.008552956,
0.01981734,
-0.00914442,
-0.0050008544,
0.009370372,
-0.004941044,
-0.011869138,
0.034397904,
-0.014234991,
-0.022887632,
0.005781719,
-0.018833783,
-0.0021299322,
0.008526374,
0.0072636995,
-0.021173054,
0.023339536,
0.0033926063,
0.049443666,
-0.0102343075,
0.0066157486,
0.012055216,
-0.0376144,
-0.024323093,
0.0007999706,
-0.015510957,
-0.002483813,
0.0010657967,
0.02651616,
-0.0028028046,
-0.0076358565,
0.017757187,
-0.015191965,
-0.012686553,
-0.03078267,
-0.027699085,
0.008353587,
0.035780203,
-0.006722079,
-0.021797745,
-0.027619338,
0.015803365,
0.03617894,
0.00252701,
-0.022595223,
0.00013343227,
0.0024422777,
-0.0053863027,
-0.0049078153,
-0.00040808468,
0.0044725253,
-0.0007472207,
-0.019431893,
0.024349676,
-0.03253712,
-0.009848859,
-0.003837865,
0.0023409317,
0.0081143435,
0.0068117953,
0.013663464,
0.011463753,
-0.004519045,
-0.0035853302,
0.010892226,
0.001535146,
-0.01010804,
0.029506704,
-0.012374207,
0.011968823,
0.0006778567,
0.011443816,
-0.00925075,
0.022010406,
-0.03383967,
-0.029081382,
-0.012154901,
0.025107281,
0.02662249,
0.009058027,
-0.024309803,
0.0016082482,
-0.001249383,
0.0076890215,
-0.0051005394,
-0.002124948,
0.0048712646,
0.0094036,
-0.0053995936,
-0.009642844,
-0.65457034,
-0.018528083,
-0.014088786,
-0.0038013142,
0.011563438,
0.013357764,
0.027566172,
0.01677363,
-0.040485322,
0.026290206,
0.0084333345,
0.046306916,
0.0166673,
-0.030835833,
-0.0064994497,
-0.018062888,
-0.013324536,
-0.01981734,
0.002804466,
-0.015032469,
-0.023818024,
0.028018078,
-0.0040073292,
0.019790757,
0.0044127144,
0.024429424,
0.034211826,
-0.021199636,
-0.017052747,
-0.009476703,
-0.010878935,
0.02327308,
-0.0054660505,
0.021997115,
0.049682908,
-0.029426957,
0.009310561,
0.012726427,
0.005296586,
0.028443398,
-0.003572039,
-0.016095774,
0.0076690847,
-0.00095946627,
-0.030330764,
-0.0030802607,
-0.0055424753,
0.005396271,
0.022010406,
-0.01614894,
0.02307371,
0.00047101072,
-0.023299662,
-0.015617287,
-0.00009459673,
-0.022900924,
0.019644553,
-0.013590362,
-0.012945734,
0.0065393234,
-0.005263358,
-0.000018600043,
-0.021717997,
-0.011762807,
-0.01921923,
0.011231155,
0.004399423,
0.016348308,
0.0025519312,
0.009330498,
0.008008013,
0.015258421,
-0.016321726,
0.0044027455,
0.03495614,
0.0012585208,
-0.0018906886,
-0.0009636198,
-0.035434626,
0.012507121,
0.0023475774,
-0.0034258347,
0.00023135183,
0.0116166035,
0.018448336,
-0.0071905977,
-0.027991494,
0.010958684,
0.0006267682,
-0.0012443986,
0.008287131,
0.0073833214,
0.0035155509,
-0.012573577,
0.004392777,
0.023831315,
-0.0042598643,
0.010586527,
-0.018541375,
-0.035115637,
-0.017704021,
-0.033042192,
0.01626856,
0.021212928,
0.0011995406,
-0.0009362065,
-0.031872556,
0.00955645,
0.05842859,
-0.02224965,
-0.026183877,
-0.007968139,
-0.010015001,
-0.023113584,
0.0026433088,
-0.037959974,
0.016906543,
-0.01148369,
0.026037673,
-0.04085748,
0.03229788,
0.007562754,
0.024376258,
-0.008499792,
-0.00015077327,
0.014779935,
-0.008552956,
-0.013876125,
-0.004110337,
-0.02073444,
0.03466373,
-0.0023043805,
0.020375576,
0.00551257,
0.036604263,
-0.021053432,
0.012088444,
-0.007642502,
-0.0123609165,
-0.0133046,
-0.024628794,
-0.0061738123,
0.0039608097,
0.004146888,
-0.009928607,
-0.03535488,
0.0011762808,
-0.0031367487,
-0.0064628986,
-0.012713136,
0.008446626,
-0.011882429,
-0.012201421,
0.019259105,
-0.00035512712,
-0.011590021,
-0.008061178,
-0.033387765,
-0.0047981623,
-0.0123609165,
0.008240611,
0.018036304,
0.017810352,
-0.018368587,
-0.01371663,
0.0039309044,
0.00035616552,
0.017544527,
0.0045223674,
-0.03259029,
0.0039907154,
-0.027964912,
-0.011756162,
0.027380094,
0.0012975639,
0.03293586,
-0.014301447,
-0.028337069,
0.000027101807,
0.00010176158,
0.0041136597,
0.010420386,
-0.0017345157,
0.0056122546,
0.03365359,
-0.009177648,
-0.0081808,
-0.006506095,
0.0032231421,
0.018754035,
-0.012301105,
0.02438955,
0.0029224262,
0.027964912,
-0.0122479405,
-0.000053009473,
-0.015790073,
0.010207725,
0.028416816,
0.036524516,
0.023605363,
-0.010746023,
0.025466146,
-0.003648464,
0.013955873,
0.0027114267,
0.010380511,
-0.013244788,
0.04146888,
-0.020388866,
0.011849201,
-0.017252117,
-0.0115102725,
0.00017434458,
0.0025585769,
0.0030470323,
0.0010142929,
-0.005814947,
-0.017890101,
0.024987658,
-0.008260548,
0.007921619,
0.020800896,
-0.012327688,
-0.0048014848,
-0.00376144,
0.01614894,
0.022103446,
-0.006838378,
-0.0009154388,
-0.01117799,
-0.03110166,
0.021159763,
0.004764934,
0.015431209,
-0.006054191,
-0.0018209092,
-0.02012304,
0.0047184145,
0.0068117953,
-0.01646793,
0.01463373,
0.002382467,
0.0074431323,
-0.002801143,
0.0047715795,
0.010885581,
0.0327232,
0.005323169,
0.034982722,
0.02114647,
0.004957658,
-0.006432993,
-0.0036584325,
-0.0007796183,
0.002345916,
-0.011397297,
0.01614894,
0.031154826,
0.04197395,
0.03453082,
0.017637566,
0.0033660238,
-0.0015309926,
0.0015434531,
-0.0050407285,
-0.010015001,
0.004459234,
-0.0085396655,
0.003113489,
-0.0033676852,
-0.026502868,
0.0070975586,
-0.010420386,
-0.00007735957,
0.021797745,
0.021917367,
-0.00487791,
0.005176964,
0.005878081,
-0.021465462,
-0.010819125,
0.020561654,
0.01606919,
-0.014141952,
-0.006163844,
0.011842555,
0.014966013,
-0.021186344,
-0.0021614989,
-0.0024688605,
-0.0020285859,
0.026011089,
0.00004945301,
0.010327347,
-0.012274523,
0.021279383,
-0.031659894,
-0.0024755062,
-0.016893253,
0.0020086488,
-0.010134622,
-0.0008174154,
-0.03136749,
0.025731971,
-0.008353587,
-0.007356739,
-0.03769415,
-0.028469982,
-0.009622907,
0.01738503,
-0.018448336,
-0.021080015,
0.01371663,
0.018847074,
0.009981772,
-0.012713136,
0.006619071,
0.021824328,
-0.025678806,
-0.0031151504,
-0.029745948,
-0.022076862,
-0.021585084,
0.053723466,
0.017664148,
0.01016785,
0.01767744,
-0.0077554784,
0.029613035,
0.003110166,
-0.018049596,
0.004239927,
0.015072343,
0.0024422777,
-0.0036218814,
0.018368587,
0.013876125,
0.0126799075,
0.02651616,
0.018594539,
-0.019870505,
0.008240611,
0.026130712,
0.0028759066,
-0.009895379,
0.025147155,
0.058588084,
0.02307371,
-0.010606464,
0.018966697,
0.020867353,
0.011038431,
-0.007084267,
-0.0026466318,
0.014952721,
-0.0003447433,
0.025253486,
-0.008945051,
-0.03344093,
0.0053464286,
-0.016374892,
0.020601528,
-0.0017893424,
0.03243079,
0.00005695533,
-0.0012601821,
0.0062867887,
0.014141952,
0.0017345157,
0.01565716,
0.023459159,
-0.021252802,
-0.019338854,
0.017850226,
-0.00033788997,
-0.011290966,
-0.002756285,
0.0016024333,
-0.0034258347,
0.0053132004,
-0.016321726,
0.0016057561,
-0.019551514,
-0.021080015,
-0.027964912,
0.016441347,
-0.0041169827,
-0.017185662,
-0.020069875,
-0.042638514,
-0.005093894,
0.0072304714,
-0.0011056707,
0.003419189,
-0.009629552,
-0.0043462575,
0.022223067,
-0.0075029433,
0.0076890215,
0.019471766,
0.0046586036,
-0.015138799,
0.026489576,
-0.021811036,
0.020362284,
0.009489994,
-0.01412866,
-0.0009478364,
0.0008045395,
-0.013809669,
-0.034211826,
0.00706433,
0.03474348,
0.005492633,
-0.0075029433,
-0.008805491,
0.0012252924,
-0.012586868,
0.0006815949,
0.012002051,
0.01900657,
-0.015869822,
-0.007948202,
-0.012115027,
-0.045057535,
-0.0040172976,
-0.01676034,
0.00036114975,
0.003628527,
-0.015417917,
-0.01067292,
-0.013131812,
-0.03609919,
0.00060807733,
-0.014806517,
-0.014460943,
-0.001430477,
0.027991494,
0.02165154,
0.008559602,
0.02134584,
0.04258535,
0.0051304447,
-0.0004988394,
0.015484374,
0.00551257,
0.0042598643,
-0.018793909,
0.01036722,
0.0037082748,
-0.018302131,
-0.033494096,
0.006070805,
-0.01402233,
0.03535488,
0.01148369,
-0.03463715,
-0.025346525,
0.001436292,
-0.02143888,
-0.0018009723,
0.018009722,
-0.02032241,
0.007310219,
0.004914461,
-0.0138495425,
-0.0009868796,
0.01382296,
-0.020481905,
-0.0020435385,
0.0069447085,
-0.013862834,
-0.013337827,
-0.01382296,
-0.007662439,
-0.014660313,
0.019126192,
-0.02234269,
-0.00376144,
0.005436145,
0.000042106447,
0.023392702,
0.0016065869,
0.027885163,
0.009124483,
0.0041070143,
0.017132496,
0.02712756,
0.0060209623,
0.0033759922,
0.0100216465,
-0.00980234,
0.033281434,
0.017929975,
0.0050806026,
-0.0014653667,
-0.018940113,
0.013098584,
0.013430866,
-0.007396613,
-0.026901606,
-0.019857215,
-0.03942202,
-0.007868454,
0.0068450235,
-0.0030270955,
-0.00074597466,
-0.046998065,
-0.000034058976,
0.0051005394,
0.017145786,
-0.005834884,
0.0030686308,
0.019777466,
-0.007436487,
0.005991057,
0.0025070729,
-0.01747807,
-0.012653325,
-0.011875784,
-0.009828922,
-0.0017411613,
0.019857215,
-0.008898531,
0.012766302,
0.01371663,
-0.02214332,
-0.002635002,
0.010925455,
-0.024309803,
-0.030118104,
-0.005725231,
-0.0209471,
0.018036304,
-0.0100216465,
-0.017717313,
-0.011982114,
-0.019059736,
-0.0027795448,
-0.009416891,
0.009503285,
-0.0077887066,
0.0012826112,
0.008526374,
-0.021399006,
0.02642312,
-0.019471766,
0.029533286,
0.02174458,
-0.02753959,
-0.02062811,
-0.00706433,
0.015869822,
0.005389625,
0.02234269,
0.042133447,
-0.023405993,
0.0029323949,
0.01971101,
0.03492956,
-0.017810352,
-0.042106863,
0.029905442,
0.016095774,
-0.00056238845,
-0.027858581,
0.009855505,
-0.043143585,
0.047104396,
0.000064847045,
0.009416891,
0.021133179,
-0.022196485,
-0.0036019445,
0.015125508,
-0.030277599,
0.016720464,
0.0066755596,
-0.017903391,
-0.005027437,
-0.030942164,
0.0052766493,
0.00051213073,
-0.0028210802,
0.03567387,
-0.013331181,
-0.0070776213,
0.003399252,
0.00093205296,
-0.006918126,
0.012746364,
-0.019644553,
0.030756086,
-0.016175522,
-0.0088586565,
0.014527399,
-0.0095963245,
0.0042964155,
0.00076881907,
0.002872584,
-0.0042000534,
-0.0315004,
-0.01971101,
0.025878176,
0.027592756,
-0.0077089584,
-0.00706433,
-0.009237459,
0.0008523051,
0.023525614,
-0.024004102,
0.010314055,
-0.035514373,
0.012686553,
-0.0090713175,
0.009264042,
0.002688167,
0.018262258,
0.0017810352,
-0.0006292604,
0.011284321,
-0.044073977,
0.02246231,
0.011849201,
-0.010121331,
-0.01178939,
0.0013017175,
-0.03740174,
-0.011337485,
-0.00094202143,
0.015803365,
-0.03963468,
-0.026183877,
-0.0035820075,
0.0058249156,
0.019059736,
-0.00551257,
0.023419285,
0.022449018,
-0.004339612,
0.011350777,
-0.00990867,
0.008632705,
-0.011350777,
0.016175522,
0.014447652,
-0.030809252,
0.020774314,
0.004306384,
0.021399006,
-0.013111875,
-0.046652492,
-0.010932101,
-0.019578097,
0.010912164,
-0.016973,
-0.0066091027,
-0.016454639,
-0.0080146585,
-0.006761953,
0.013603654,
0.01971101,
-0.008340295,
0.0009287301,
-0.0014329691,
0.00016437609,
-0.006678882,
0.004186762,
-0.014686896,
0.0055624126,
-0.006858315,
-0.02886872,
-0.010699503,
0.004399423,
0.033175103,
0.014248282,
-0.014500817,
-0.023113584,
-0.02894847,
-0.042239778,
0.02407056,
-0.027047811,
0.005748491,
0.00647619,
0.019458475,
0.00037174128,
0.0074830065,
0.005047374,
0.015417917,
-0.03240421,
-0.03570045,
0.0126732625,
-0.023592072,
0.025692098,
-0.0005902171,
-0.049736075,
0.012573577,
0.036072608,
-0.0041601793,
-0.0017743896,
0.008652641,
-0.0072304714,
-0.02275472,
0.016800214,
0.014686896,
-0.011503627,
0.0029739302,
-0.027459841,
-0.034557402,
-0.0029739302,
0.0056787115,
-0.003359378,
-0.004153534,
0.0048081307,
0.00038794006,
0.010387157,
-0.0077156043,
-0.02093381,
-0.029426957,
0.010885581,
-0.017198952,
0.004123628,
0.0064197015,
0.02377815,
0.011503627,
0.010878935,
0.008067824,
0.0065559377,
0.0041402425,
0.0059179547,
-0.017863518,
0.0078086434,
-0.0029407018,
0.010008355,
-0.0013980794,
0.006416379,
0.004399423,
0.004495785,
-0.00009625815,
-0.006240269,
-0.0075760456,
0.0126732625,
0.013756503,
-0.021664832,
0.01336441,
0.013503969,
-0.012168192,
-0.0068250867,
-0.008765617,
0.0072703455,
-0.009722591,
0.0030603237,
-0.015843239,
-0.008260548,
0.010154559,
0.004844682,
-0.030118104,
-0.009011507,
0.014301447,
0.20192155,
0.0019621293,
0.014141952,
-0.010540008,
-0.021266093,
0.029613035,
0.013032127,
0.0077887066,
0.0022080184,
0.030251017,
0.0030121426,
0.010785896,
0.00024713526,
0.0055757035,
0.014234991,
-0.023950936,
-0.023339536,
-0.016919835,
0.011357423,
-0.01305871,
-0.0056521287,
0.02327308,
0.0073633846,
-0.0087922,
0.02500095,
-0.011815973,
-0.014195117,
-0.0031168116,
0.010573235,
0.016308434,
-0.010679566,
-0.017278701,
-0.003841188,
0.0072371173,
0.006280143,
-0.018222382,
-0.022821175,
0.0012676585,
-0.0025901436,
0.0018292163,
-0.0056421603,
0.021119889,
-0.028576313,
-0.013457449,
0.018129343,
0.023206623,
0.0031932367,
-0.016388183,
-0.02529336,
-0.012181483,
-0.038943533,
-0.022302814,
0.009536513,
-0.009031444,
-0.003837865,
0.013543842,
0.035035886,
0.00059395534,
-0.018421752,
0.013889417,
-0.0024372935,
-0.008087761,
-0.011576729,
0.019378727,
0.003668401,
0.015790073,
-0.011477045,
-0.012028634,
-0.0060010254,
-0.00011276844,
0.02643641,
-0.028496563,
-0.0069779367,
0.0057152626,
-0.013902708,
-0.013484032,
0.021970533,
0.026835151,
0.02894847,
0.013078647,
-0.007895037,
-0.008446626,
-0.027114268,
0.021717997,
-0.034557402,
-0.0067519844,
0.010094748,
0.01041374,
-0.027273763,
0.034716897,
-0.005685357,
-0.005761782,
-0.008400107,
0.0038478337,
0.008898531,
0.015072343,
0.0011056707,
-0.005934569,
0.009230813,
-0.0056355144,
-0.0046486347,
0.06757301,
0.010772605,
0.015072343,
-0.0025801752,
-0.018461626,
-0.0376144,
0.0072371173,
0.003475677,
-0.04468538,
0.022076862,
-0.050214563,
-0.00023716678,
-0.032670036,
-0.0033460867,
0.029692782,
-0.0011463753,
-0.011078306,
0.01828884,
-0.023671819,
0.008672578,
-0.028469982,
-0.008107698,
0.03312194,
-0.019152775,
-0.009350435,
-0.028124407,
-0.022940798,
-0.01209509,
-0.018062888,
0.018049596,
-0.014221699,
-0.0030171268,
-0.0011654815,
-0.002013633,
0.0044392967,
-0.016574262,
-0.014301447,
-0.014779935,
0.014527399,
-0.003934227,
-0.005143736,
-0.0148995565,
-0.0032115122,
-0.0022977348,
-0.030251017,
0.01006152,
0.005333137,
-0.026476284,
-0.0077488325,
0.029347207,
-0.005991057,
-0.010613109,
-0.02948012,
0.003688338,
-0.016600844,
0.00028929362,
-0.013098584,
0.00083859847,
0.017012874,
-0.010706148,
0.009489994,
0.049975317,
-0.0010948714,
-0.012154901,
0.023552198,
-0.16885278,
0.027778834,
0.018023014,
0.003263016,
0.02948012,
0.0016348308,
0.011796036,
0.022369271,
0.0036617552,
0.013052064,
0.019059736,
0.009848859,
-0.0188072,
-0.007921619,
0.012533703,
0.021452172,
-0.008373524,
0.048513275,
0.04423347,
0.012367562,
0.012374207,
-0.022223067,
0.0031334257,
0.0040804315,
0.016946418,
0.0072437627,
-0.0032895987,
-0.0042698327,
-0.013198269,
0.0098089855,
-0.0031483786,
0.010739377,
0.043781567,
-0.0042166673,
-0.032802947,
-0.010141268,
-0.018009722,
0.013151749,
0.007994722,
0.019139484,
0.050480388,
0.016999584,
-0.0057086167,
-0.011556792,
-0.013244788,
0.033680174,
0.04165496,
-0.0081143435,
0.007948202,
0.0052899406,
0.01746478,
-0.023246497,
0.026157293,
0.010254244,
-0.0038644478,
-0.005748491,
0.0025220257,
0.008566248,
0.010732731,
0.009855505,
-0.0035454563,
-0.013085293,
0.035806783,
0.009157711,
0.0077687693,
-0.03445107,
-0.0016223702,
0.0050407285,
0.010307409,
0.03038393,
-0.03017127,
0.0064064106,
-0.00043072144,
-0.002334286,
0.024402842,
0.012965671,
-0.019737592,
0.016973,
0.011922304,
0.0002751716,
-0.0024007424,
0.0030885676,
-0.020455323,
0.0051304447,
-0.0065193865,
-0.013497323,
0.00838017,
0.014394486,
-0.019139484,
-0.0041435654,
-0.013477386,
-0.029719364,
0.0036185586,
-0.012347625,
-0.0087523265,
0.035620704,
-0.013623591,
0.0049510123,
-0.0026848442,
-0.016693883,
0.012394144,
-0.021797745,
-0.025532603,
0.0051370906,
0.0038578021,
-0.015976151,
-0.0031284415,
0.007934911,
0.041734707,
0.0019554836,
-0.025160445,
0.030277599,
-0.000138105,
0.013191623,
-0.010898872,
0.025545893,
-0.019750884,
-0.017624274,
-0.00043612104,
-0.015391335,
0.051331032,
0.0011970485,
-0.02235598,
0.01848821,
-0.025545893,
-0.00807447,
-0.11387993,
-0.013969164,
0.013942582,
0.010486842,
-0.0076557933,
0.033148523,
0.0036816923,
0.0007625888,
-0.017557818,
0.014234991,
-0.023538906,
-0.033494096,
-0.02509399,
-0.012327688,
0.02093381,
-0.00020373083,
0.009244105,
-0.021824328,
-0.0140622035,
0.03668401,
0.013484032,
-0.010726086,
0.01524513,
-0.011098242,
0.018621122,
-0.013457449,
-0.010048228,
0.024083849,
-0.0068184407,
0.04077773,
0.0047416743,
-0.008127634,
0.002105011,
-0.01087229,
-0.024615502,
-0.035833366,
-0.021279383,
-0.016135648,
0.028018078,
-0.048433527,
0.011144762,
0.008366878,
-0.0019455152,
-0.010985266,
0.031580146,
0.0002672799,
-0.0053863027,
-0.0030769377,
-0.011955531,
-0.02348574,
-0.01706604,
-0.029852277,
-0.016241979,
-0.0043163523,
-0.0050407285,
-0.036497932,
0.01981734,
0.010221016,
-0.017438196,
-0.0057052937,
-0.008300422,
0.014474235,
-0.009244105,
0.029187713,
0.016893253,
-0.021877492,
-0.009529868,
-0.002872584,
0.018368587,
-0.0057019712,
-0.008267193,
-0.017119205,
-0.024416132,
-0.0059677972,
-0.025173737,
0.0045024306,
-0.010759314,
-0.033573844,
0.017132496,
-0.004821422,
-0.010606464,
-0.014726769,
0.026343372,
0.0090979,
0.03341435,
-0.0032995671,
0.010858999,
-0.010892226,
-0.006685528,
-0.0053132004,
0.0022196483,
0.019764176,
-0.005479342,
-0.009197585,
0.015444499,
-0.011417233,
-0.014088786,
-0.021452172,
0.006619071,
-0.0017361771,
-0.03726883,
-0.0010383835,
-0.061246347,
0.0102343075,
0.029852277,
-0.0010101394,
0.011709643,
-0.00063050643,
-0.004552273,
-0.0023376087,
0.013344473,
0.004668572,
-0.0068848976,
0.02173129,
-0.011423879,
0.011849201,
-0.023259789,
0.006798504,
0.024416132,
0.0014944414,
0.03769415,
0.02894847,
0.013477386,
-0.006951354,
0.011443816,
0.020309119,
0.024349676,
-0.001070781,
0.014966013,
0.016255269,
-0.00899157,
0.0061771353,
0.01382296,
-0.017451487,
-0.002728041,
0.009795694,
0.012859341,
-0.023020545,
0.0203357,
0.028576313,
0.013377701,
0.019538222,
-0.017850226,
-0.021013558,
0.004459234,
-0.00678189,
0.009137774,
0.015776783,
-0.012321043,
0.019950254,
0.007197243,
-0.01747807,
0.028097825,
0.008626059,
-0.0023857898,
-0.017704021,
-0.028390234,
0.016335018,
-0.002036893,
-0.0074431323,
-0.011397297,
-0.00980234,
0.017531235,
-0.0071773063,
0.011875784,
0.01960468,
0.01133084,
-0.034690313,
0.008373524,
0.006951354,
0.0017179016,
0.010068166,
-0.009171003,
-0.008140926,
-0.01594957,
0.016042609,
0.010759314,
-0.0050108233,
-0.02073444,
0.01504576,
-0.013982456,
0.0069447085,
0.0008523051,
-0.004691832,
-0.00838017,
0.01646793,
0.023950936,
0.008672578,
-0.0062668514,
0.025652224,
-0.011835909,
-0.012832758,
-0.014926138,
0.006625717,
0.0005727723,
-0.002487136,
-0.012812821,
0.039475184,
0.012779593,
-0.0076690847,
0.0029838986,
0.005176964,
-0.014234991,
0.017863518,
-0.022714846,
-0.04317017,
0.00029780838,
0.011011848,
-0.0203357,
-0.035035886,
-0.026768694,
0.016281852,
0.028496563,
0.026875025,
0.0010957022,
-0.0029589774,
-0.0011123164,
-0.008679224,
-0.009523222,
0.0136368815,
-0.019777466,
0.0033195042,
-0.009264042,
0.011782745,
-0.0013241465,
-0.008599476,
0.019897088,
0.011596666,
0.008233965,
-0.009775757,
0.027964912,
-0.009190939,
0.013530551,
-0.012267877,
-0.023392702,
-0.0011065013,
-0.011796036,
-0.024243345,
0.027805416,
-0.009430183,
-0.014540691,
0.07751491,
0.009921961,
-0.02287434,
-0.0041601793,
-0.004279801,
-0.00062053796,
0.008772263,
0.017345157,
-0.007463069,
-0.03769415,
0.01290586,
-0.01767744,
0.017252117,
-0.042133447,
0.002483813,
-0.0063665365,
-0.0011231155,
0.023233207,
-0.0029390405,
-0.011078306,
0.0035786848,
0.0039475183,
-0.012267877,
-0.0060342536,
-0.018235674,
-0.020986974,
0.007137432,
0.00071897666,
-0.0024755062,
-0.021252802,
0.0017112559,
0.00079124817,
-0.03229788,
-0.016321726,
0.016786922,
-0.010513425,
-0.009004861,
-0.016441347,
0.0032414177,
-0.005147059,
-0.0070311017,
-0.00406714,
-0.008160863,
-0.016029317,
-0.027326928,
-0.025838302,
-0.017438196,
-0.016135648,
-0.009416891
] |
Taking advantage of the restricted expression of metabotropic glutamate receptor subtype 6 (mGluR6) in retinal ON bipolar cells, we generated knockout mice lacking mGluR6 expression. The homozygous mutant mice showed a loss of ON responses but unchanged OFF responses to light. The mutant mice displayed no obvious changes in retinal cell organization nor in the projection of optic fibers to the brain. Furthermore, the mGluR6-deficient mice showed visual behavioral responses to light stimulation as examined by shuttle box avoidance behavior experiments using light exposure as a conditioned stimulus. The results demonstrate that mGluR6 is | [
-0.02581809,
-0.0063165636,
-0.002043111,
-0.040835943,
-0.02814369,
0.024215136,
-0.007751997,
-0.008632309,
-0.015267492,
-0.0075417734,
0.013388618,
0.0045033847,
-0.003265036,
-0.007673163,
-0.014702516,
0.012777656,
0.03429273,
0.0022303415,
0.023728995,
0.01645,
-0.008113319,
0.017658787,
-0.00924984,
-0.016410584,
0.018079234,
-0.011299521,
-0.0014723866,
-0.04317468,
-0.027591852,
-0.017330311,
0.0021153754,
0.012252097,
0.004999381,
-0.01375651,
-0.0048384285,
-0.015451438,
0.0068585463,
-0.0031073682,
0.0011168132,
0.0073709665,
0.021416534,
0.0077322884,
-0.020128913,
0.0021203025,
0.00758119,
0.020680752,
-0.0066483226,
-0.0058698384,
-0.0064446684,
0.0075877598,
0.0021055213,
0.008428655,
-0.0022664736,
-0.019511381,
-0.013283506,
-0.006838838,
0.020365415,
-0.011128714,
-0.0038398663,
-0.030088259,
0.011470327,
0.0059191096,
-0.033057667,
0.0053048623,
-0.007758566,
0.016647086,
-0.0044409744,
0.009322105,
0.009354952,
-0.01966905,
0.041598003,
0.025936343,
-0.013769649,
-0.017172644,
0.035580352,
-0.030824041,
-0.027355352,
-0.0027279803,
0.006030791,
-0.00045740066,
0.03224305,
-0.014084985,
-0.015740495,
0.03339928,
-0.0014764926,
0.018184345,
0.01003161,
0.017317172,
0.0049172626,
0.012869629,
-0.019958107,
0.024004912,
0.010222125,
0.01684417,
-0.0000038396865,
0.0026770667,
-0.018617932,
0.027171407,
-0.007239577,
0.012284944,
-0.0069176718,
0.010852796,
-0.015635384,
-0.02171873,
0.01144405,
-0.0009919928,
-0.013066714,
-0.013861622,
0.024504194,
-0.01811865,
-0.012265236,
0.02249393,
-0.02070703,
-0.024228275,
-0.012600279,
0.019458827,
0.014584266,
0.020365415,
-0.020299722,
-0.0004656125,
0.0041059307,
0.0072527155,
-0.0009451852,
-0.0042176116,
0.025988897,
0.03416134,
-0.0055840653,
-0.007949081,
-0.018525958,
-0.0013631689,
0.0070424923,
0.0025982328,
0.00951919,
-0.000094949646,
0.0054231132,
0.024714418,
0.004923832,
0.005436252,
-0.0280123,
-0.020220887,
-0.0023765126,
0.0072789937,
-0.020601917,
0.004276737,
0.002241838,
0.030561263,
0.011765955,
-0.000992814,
0.004641344,
0.00125313,
0.002430711,
-0.021666175,
0.011746246,
0.0016760408,
0.037235864,
0.004362141,
-0.026264817,
0.043673962,
-0.014374042,
0.0076468852,
-0.0012416334,
-0.032453276,
0.0056858924,
0.01941941,
0.025161142,
0.023518771,
0.0057285945,
0.0026852787,
0.00443112,
-0.0051439097,
0.006878255,
0.029930592,
-0.013914177,
0.039863657,
-0.017422285,
0.024201997,
0.0042964458,
0.0137039535,
-0.009571745,
0.0011611572,
-0.041965894,
0.010773961,
-0.003636212,
-0.012652836,
-0.011601717,
0.02250707,
0.023085184,
-0.0018345298,
0.00013118448,
-0.022638459,
-0.0043851337,
0.008494349,
-0.010806809,
-0.009867372,
-0.6403412,
-0.012475459,
0.012429473,
-0.008027916,
-0.01284992,
0.02929992,
0.014242652,
-0.005347564,
-0.0059913737,
0.014544848,
-0.017908426,
0.009611162,
-0.0006384722,
-0.040678274,
-0.02711885,
-0.027696965,
-0.005873123,
0.01375651,
0.03292628,
-0.013414896,
-0.015648523,
0.0037741715,
-0.014636821,
0.019826718,
0.014229513,
0.028091135,
0.027959745,
-0.03395112,
-0.018801877,
0.031691216,
-0.025397643,
0.037367254,
-0.0078571085,
0.0014214731,
0.04858794,
-0.014203235,
-0.0001390884,
0.03547524,
-0.003688768,
0.05310775,
-0.010747684,
0.0048778453,
0.026685264,
-0.018289456,
-0.035790574,
0.0032239766,
-0.0034489816,
0.01618722,
0.029273642,
-0.009269549,
-0.0030416735,
0.0123046525,
-0.025739258,
0.0009698208,
0.02442536,
-0.0012720173,
0.025279393,
0.015096686,
0.007751997,
-0.0045460863,
-0.016923003,
0.015793052,
-0.0015881739,
-0.023347963,
-0.0030860174,
0.003455551,
-0.01646314,
-0.010911921,
0.017474841,
0.023597604,
0.0035245307,
0.019274881,
-0.02378155,
0.033373002,
0.009085603,
0.036710303,
0.009492911,
0.008159305,
0.018026678,
0.012902476,
-0.0062114517,
0.0023666583,
-0.024583027,
-0.0022779703,
0.030193372,
-0.0038595747,
-0.0053409943,
0.009795108,
0.004470537,
0.002877436,
0.012370348,
-0.005258876,
-0.021350838,
-0.01646314,
-0.029010862,
0.026711542,
-0.011601717,
0.026777236,
0.015648523,
-0.01836829,
-0.026829792,
-0.0013073282,
0.01952452,
0.007600899,
0.014374042,
0.006500509,
-0.023479354,
-0.013191533,
0.03920671,
-0.02299321,
-0.013086421,
-0.011976178,
0.0066286144,
0.012022165,
0.0033258037,
-0.026080871,
0.027276518,
0.0042833067,
-0.013211242,
-0.028564138,
0.01079367,
-0.001980701,
0.01874932,
-0.0060439296,
0.0072461464,
0.0036165037,
-0.007568051,
-0.00861917,
-0.0026245108,
0.0077717053,
0.015017851,
-0.010629433,
0.013730232,
-0.022677876,
0.01685731,
-0.0024175718,
0.007482648,
0.0050946386,
0.007351258,
-0.038339537,
-0.037997924,
-0.0040303813,
-0.00026750137,
0.0026245108,
0.009801677,
-0.011404633,
0.013165256,
-0.005242452,
0.00558735,
-0.013730232,
-0.0009804962,
-0.01811865,
0.0015701079,
0.022020927,
0.008316973,
-0.020904114,
-0.024083747,
0.005193181,
0.005088069,
0.0036263578,
0.015832469,
0.0046939,
0.021311423,
0.016489416,
-0.024254553,
-0.021666175,
-0.0035672325,
0.018460264,
0.005807428,
-0.018854434,
-0.014374042,
-0.015858747,
-0.010911921,
0.014071845,
-0.018841295,
0.0087702675,
0.0019347145,
-0.0075877598,
-0.0031122954,
-0.008205292,
0.0004315333,
-0.0015035918,
-0.023177156,
-0.011608287,
0.012495168,
0.018552236,
0.015858747,
0.039627157,
0.0008339145,
0.007758566,
0.005810713,
0.043884184,
-0.013717093,
0.019655911,
-0.008645447,
-0.0091972845,
0.025647284,
0.0020299722,
-0.017934704,
0.039522044,
0.009407508,
-0.028774362,
0.010583446,
-0.004651198,
0.029641533,
-0.03045615,
0.010491474,
-0.036184743,
-0.011187839,
-0.004017242,
0.008500919,
-0.0024110025,
-0.0052128895,
-0.015306909,
0.0031303614,
-0.0045033847,
-0.016765336,
0.005170188,
-0.008257847,
-0.03918043,
-0.012974741,
0.01990555,
0.008520627,
0.010261541,
0.016121525,
0.016476277,
-0.016673362,
0.0044771065,
0.0047333166,
-0.00443112,
-0.0046643373,
0.019274881,
0.0053147166,
0.0144397365,
-0.020339137,
0.0118776355,
0.0049665337,
-0.0073184106,
0.046196647,
0.012035304,
0.01349373,
0.034792013,
-0.008428655,
0.014610543,
-0.008047624,
-0.01798726,
0.0050322283,
-0.0068322686,
-0.0013951953,
0.019104073,
-0.009781969,
0.026908627,
-0.013428035,
0.007502356,
0.0038004494,
-0.003767602,
-0.00070170354,
0.02338738,
0.04548714,
0.013520008,
-0.0104192095,
-0.0035179614,
0.0042734523,
-0.021797564,
-0.021771286,
0.025148004,
0.010852796,
0.027092572,
0.0022976787,
0.0074563697,
-0.019485105,
-0.012797364,
-0.0059585264,
-0.020299722,
0.005692462,
0.010182708,
0.007239577,
0.008908227,
0.041939616,
0.008678295,
-0.013795926,
-0.02816997,
0.024057468,
0.025266254,
-0.011871066,
-0.024990335,
-0.024990335,
0.018276319,
-0.0075286343,
-0.0137039535,
-0.004572364,
0.00048449982,
-0.0023288839,
-0.010780531,
-0.013362341,
-0.016082108,
0.03379345,
-0.0060964855,
0.0197873,
-0.008225,
0.008540335,
0.0061621806,
-0.0058501298,
0.01646314,
0.0068519767,
0.0143214855,
-0.013559425,
-0.010576877,
-0.0086520165,
-0.01503099,
0.0029874751,
-0.00091315893,
0.0055774963,
-0.016620807,
-0.014203235,
0.0067797126,
-0.02365016,
0.009460064,
0.015477716,
-0.016174082,
-0.024898363,
-0.036079634,
0.005925679,
-0.03673658,
0.029983148,
0.017947843,
-0.01362512,
0.026580151,
-0.003971256,
0.006746865,
-0.031034265,
-0.019892413,
-0.0012022165,
-0.019852996,
-0.008369529,
0.015451438,
0.00062286964,
0.001773762,
0.013047005,
-0.00089345046,
0.00526873,
-0.0053048623,
0.01580619,
0.00005006669,
0.015517132,
0.018184345,
0.0026934904,
0.031822603,
0.022204872,
-0.010655711,
-0.0032420428,
0.008218431,
0.0045001,
-0.010951338,
-0.0042668832,
-0.014755072,
0.009650579,
-0.0027115566,
-0.007686302,
-0.03689425,
0.011043311,
0.000580168,
0.007909665,
-0.0036394969,
0.04254401,
0.0071935905,
0.0015389028,
-0.0061227637,
-0.01630547,
-0.0099330675,
-0.011726538,
0.00964401,
-0.013940455,
-0.01027468,
0.030088259,
-0.02853786,
0.00021125012,
0.0073841056,
-0.0014288638,
0.0031303614,
0.0055742115,
0.002767397,
-0.002440565,
0.0042143273,
-0.006585913,
-0.021311423,
0.000842537,
-0.018079234,
-0.009282688,
-0.010222125,
0.011621426,
-0.02121945,
-0.024451638,
-0.013152117,
0.01773762,
0.0010338733,
-0.031007988,
-0.00990022,
0.024832668,
0.009696566,
0.012409764,
-0.007292133,
0.012797364,
0.02081214,
-0.025003474,
-0.032426998,
-0.0057647265,
-0.013027296,
0.019222325,
-0.0026819939,
0.02224429,
-0.022559624,
-0.028853195,
0.001429685,
0.0060077976,
-0.04033666,
0.009026478,
-0.004155202,
0.000390474,
0.00330938,
-0.00044220872,
0.02610715,
-0.00899363,
-0.006950519,
0.00059453875,
-0.017146366,
-0.023755271,
-0.02866925,
-0.02686921,
-0.008671725,
0.0045066695,
0.011930192,
-0.007686302,
-0.015530271,
-0.015714217,
-0.021731868,
0.008658586,
0.012626558,
0.022020927,
0.009348382,
-0.007272424,
0.02391294,
0.020864697,
-0.0112141175,
0.0050782147,
-0.035895687,
0.014084985,
-0.0019363569,
-0.02006322,
0.027171407,
-0.0033865715,
-0.030508706,
-0.017527396,
-0.0046117813,
-0.0025982328,
0.033898562,
0.009926498,
-0.030508706,
-0.016660225,
0.009203854,
-0.025752397,
0.012238958,
-0.015333187,
0.02788091,
-0.026369927,
0.018433986,
-0.008625739,
-0.0076534543,
0.0038497206,
-0.03907532,
-0.0069702277,
0.021902677,
-0.008638877,
0.0044935304,
0.011733107,
-0.010701697,
-0.0375512,
-0.0262254,
-0.018315734,
-0.032584663,
-0.0064545227,
-0.015346326,
0.03749864,
0.046485703,
0.028327636,
0.018144928,
0.0048647067,
0.022099761,
0.01566166,
0.011082727,
-0.015438299,
0.0025423921,
-0.04598642,
0.013546286,
-0.00097228435,
0.006930811,
0.029194808,
0.024701279,
0.011844789,
0.030640095,
-0.008855671,
0.00036481192,
0.008678295,
-0.015017851,
-0.03726214,
0.023834106,
-0.012166694,
-0.0017244908,
-0.025476478,
-0.012968171,
0.045355752,
0.024556749,
-0.0034851138,
-0.0049566794,
0.012409764,
-0.03765631,
0.023308547,
-0.012692252,
0.0037643171,
0.0052391673,
-0.01183165,
-0.005091354,
-0.008586322,
-0.0044179815,
0.010603155,
0.013651398,
-0.004536232,
-0.009098742,
-0.0060472144,
0.0032880292,
-0.0068716854,
0.013152117,
-0.007482648,
-0.016607668,
-0.017185783,
-0.023702716,
-0.03006198,
-0.026790375,
0.007495787,
0.028564138,
-0.026120288,
0.025029752,
-0.0037807408,
-0.032059107,
0.013270368,
-0.018394569,
0.044567414,
-0.008665156,
0.017803315,
0.0014748502,
-0.01040607,
-0.009026478,
-0.01849968,
0.0023420227,
-0.0036329273,
0.03455551,
0.0077060102,
-0.014715655,
-0.0127316695,
-0.005245737,
0.0004023812,
-0.026882349,
-0.030140815,
0.015609105,
0.030561263,
0.0156748,
0.008803115,
0.00022541558,
-0.031927716,
-0.0018723044,
-0.011404633,
-0.0048909844,
-0.0076468852,
-0.019248603,
-0.03379345,
0.028642971,
0.007535204,
-0.0021120906,
0.01079367,
-0.010314098,
-0.0027033447,
-0.0033241613,
-0.0012424546,
0.0070359227,
-0.015359465,
0.034003675,
-0.0064380993,
0.007272424,
0.015070408,
0.0029809056,
0.0070753396,
-0.008008207,
-0.0042176116,
0.037603755,
-0.0029267073,
-0.0053902655,
0.015976997,
0.0077060102,
0.006838838,
-0.0022122753,
-0.0040041036,
-0.01838143,
-0.033083946,
0.0015668231,
0.028590415,
-0.011969609,
-0.010445488,
0.0034752595,
-0.019130351,
-0.007173882,
-0.043779075,
-0.016331749,
0.0033964259,
-0.04448858,
0.013211242,
-0.0031484275,
-0.0009246556,
0.036184743,
0.015622244,
-0.010977616,
0.010379792,
0.019826718,
-0.024333388,
0.025870647,
0.0014658172,
0.005219459,
-0.033215337,
0.0038825679,
-0.0060767774,
-0.046222925,
-0.002854443,
-0.03303139,
-0.025975758,
-0.022533346,
-0.018026678,
0.010110443,
0.0037380392,
0.0019117213,
0.018736182,
0.008021346,
0.030140815,
0.00010003073,
-0.0024734125,
0.002872509,
-0.022270568,
0.0018870857,
-0.014216374,
-0.0022516923,
-0.029247364,
0.0021991364,
-0.018315734,
0.021127475,
-0.0016867162,
-0.019563938,
-0.009046186,
-0.00886224,
0.0047825878,
-0.0052621607,
-0.008225,
-0.002885648,
-0.0223494,
0.033504393,
0.025042892,
-0.005488808,
-0.010057887,
0.00050010235,
-0.0058665536,
-0.0033602936,
-0.023728995,
0.005038798,
-0.0126134185,
-0.004986242,
-0.046249203,
-0.008376098,
-0.023282269,
0.050979234,
0.004036951,
-0.012922185,
-0.011529453,
0.0046971845,
-0.031428434,
-0.022520209,
-0.011036742,
-0.000121022305,
0.0047136084,
0.015241214,
-0.011358647,
-0.014623682,
0.011260104,
0.010649142,
-0.015582828,
-0.012685683,
0.019629633,
-0.0121272765,
0.038103037,
0.014965296,
-0.023518771,
-0.004329293,
0.029746646,
-0.020417972,
-0.01863107,
0.03127077,
-0.012100998,
0.038234424,
0.0023288839,
0.029483866,
0.010898782,
0.010018471,
0.015858747,
-0.012968171,
-0.022060344,
0.012606849,
0.014820767,
-0.0093286745,
0.01234407,
0.016528834,
-0.0018410992,
0.02018147,
-0.046354312,
-0.023820966,
0.016883586,
-0.0013927317,
0.00732498,
0.03752492,
0.02250707,
-0.0028183106,
0.008277556,
-0.0058698384,
-0.001266269,
-0.012028734,
-0.01027468,
0.015004712,
-0.0028971445,
0.007206729,
-0.003120507,
-0.00029316344,
-0.009269549,
-0.04151917,
0.00758119,
-0.010465195,
0.0019297873,
-0.022914378,
0.014991574,
0.004033666,
-0.013993011,
-0.0122455275,
-0.01464996,
0.0057778656,
-0.00924327,
0.007995068,
0.016791614,
-0.024727557,
-0.01503099,
0.016883586,
0.0071607428,
-0.0058205673,
-0.009184145,
-0.008330112,
-0.013914177,
0.019971246,
0.18236901,
0.010136722,
0.011509744,
0.028091135,
-0.019117212,
0.00036460662,
0.00024717703,
-0.010130152,
0.019774161,
0.017382868,
-0.013782788,
-0.0019560654,
-0.008934505,
0.0019839855,
0.020969808,
0.013158686,
-0.024766972,
-0.008711142,
-0.021534784,
-0.009013339,
0.014242652,
0.0053672725,
-0.0057680113,
-0.0052884384,
0.034634344,
0.014098123,
-0.019550798,
-0.0069767972,
0.0076468852,
0.015543411,
-0.028038578,
-0.0022549771,
0.011529453,
-0.00030979246,
0.024504194,
0.015228075,
-0.02005008,
0.011490036,
-0.0025735972,
0.02119317,
-0.0070359227,
0.0074629392,
0.008323543,
0.008888518,
-0.009630871,
0.018709904,
0.026002036,
-0.0037971647,
0.008645447,
-0.00011968787,
-0.045723643,
0.018092372,
0.030534985,
0.02108806,
0.010629433,
-0.029142253,
0.023623882,
-0.010642572,
-0.00170314,
0.020601917,
-0.030508706,
0.017658787,
-0.014741933,
0.029405031,
-0.018184345,
0.047484264,
-0.016082108,
0.016660225,
0.008428655,
-0.01592444,
-0.0053180014,
0.0006388828,
-0.03395112,
-0.0025818092,
-0.0047234623,
-0.014084985,
-0.0014920952,
0.014636821,
0.027670687,
0.009276118,
-0.004486961,
0.0023091754,
-0.026054593,
0.016883586,
-0.032716054,
-0.015530271,
0.0313496,
0.019931829,
0.008763698,
-0.012961602,
0.01826318,
0.0065432107,
-0.013027296,
0.0027509735,
-0.0038201578,
-0.014466015,
-0.010314098,
0.0059421025,
-0.033819728,
-0.0037807408,
-0.04109872,
0.05271358,
0.005797574,
-0.017106948,
-0.013204672,
0.0013180037,
0.0014756714,
0.011384924,
-0.0066384687,
0.008014777,
0.0105506,
-0.02584437,
-0.004046805,
-0.0063921125,
-0.014768211,
0.0061457567,
0.01336891,
-0.029483866,
0.015701078,
0.0015372604,
-0.0012161767,
-0.0041420627,
-0.0024208566,
0.0107279755,
-0.020496806,
0.0047825878,
0.0016760408,
0.0073709665,
0.014886462,
-0.03692053,
-0.005278584,
-0.0053672725,
0.017671926,
0.006983367,
-0.009946207,
0.0010700055,
0.015004712,
-0.007482648,
-0.019879274,
0.011417772,
-0.0008289874,
-0.0002130978,
0.028984586,
0.0053902655,
-0.004565795,
-0.027460463,
0.019169768,
0.017409146,
0.0021317992,
0.0071278955,
-0.011069588,
-0.018052956,
0.004411412,
-0.020904114,
0.009538898,
-0.02273043,
-0.00424389,
-0.042859346,
0.0010888928,
0.017120088,
-0.032190494,
0.016436862,
0.010622864,
-0.018052956,
-0.0020578925,
0.016909864,
-0.16502556,
0.009138159,
0.026685264,
-0.016108386,
0.0065891976,
-0.0013943741,
0.023978634,
-0.004730032,
-0.016936142,
0.009591454,
0.024872085,
-0.0015701079,
-0.030114537,
-0.009755691,
-0.003168136,
0.0020628194,
-0.031770047,
0.029510144,
-0.00732498,
0.012705391,
0.048535384,
-0.02543706,
0.005873123,
-0.01285649,
-0.0156748,
0.009486342,
0.0024586313,
0.0045986422,
-0.007889956,
-0.037866533,
0.0035935105,
-0.004358856,
0.02943131,
-0.005088069,
0.04356885,
-0.0018131789,
-0.014820767,
0.007311841,
0.0013631689,
0.0064380993,
0.030561263,
0.0211012,
0.005193181,
0.0032091953,
-0.020838419,
0.023150878,
0.011549162,
0.016068969,
0.0036723444,
-0.011371785,
0.019629633,
-0.019997524,
0.017632509,
0.019944968,
0.037340976,
0.0024520617,
0.014623682,
0.006635184,
-0.014873323,
-0.00080763653,
-0.018552236,
-0.022901239,
0.029851757,
-0.013966734,
0.0042340355,
-0.022388818,
0.0015627171,
-0.021232588,
-0.025161142,
-0.002440565,
-0.034765735,
-0.01620036,
0.0062377295,
-0.016725918,
0.020904114,
0.035317574,
0.016134664,
0.017882148,
0.02442536,
-0.006773143,
-0.020247165,
-0.004999381,
-0.037367254,
-0.012514876,
-0.016134664,
0.0108462265,
0.004910693,
0.038155593,
0.013861622,
0.018933266,
0.019432548,
-0.01928802,
0.011398063,
-0.017974121,
0.024556749,
0.0049402555,
-0.003128719,
-0.020720167,
0.00026380603,
0.000026534577,
0.019445688,
-0.0027772514,
-0.009965914,
-0.009026478,
0.033373002,
-0.019642772,
-0.00366249,
0.020102635,
0.025555313,
0.0016013129,
-0.0008191331,
-0.034424122,
-0.000082683175,
0.0020792433,
-0.0041420627,
-0.008415516,
-0.0073446888,
0.0023633735,
0.028695527,
-0.025857508,
0.05975607,
-0.0143214855,
0.013730232,
-0.0045920727,
0.0004249638,
-0.023203434,
-0.11541278,
-0.06984681,
0.005475669,
-0.017369729,
-0.031691216,
0.006707448,
0.019997524,
0.037630033,
-0.008323543,
0.02287496,
-0.023558186,
0.006760004,
-0.008205292,
0.011424341,
-0.0053902655,
-0.011227257,
0.027828354,
0.008881949,
-0.015188659,
0.03907532,
-0.010268111,
-0.011627995,
0.007108187,
-0.002043111,
0.0030482428,
0.0017770467,
-0.022638459,
0.02583123,
0.015714217,
0.023137739,
0.024464777,
-0.0138353435,
0.022914378,
0.0032584665,
-0.02132456,
-0.020023802,
0.01451857,
-0.030035703,
0.04125639,
-0.019130351,
-0.003432558,
0.0074235224,
0.018276319,
0.0016743984,
0.0006261544,
0.006066923,
-0.010819948,
0.014636821,
0.015083547,
-0.018026678,
-0.030482428,
-0.0041092155,
-0.02378155,
-0.0075614816,
0.029168531,
-0.0033241613,
0.0050847842,
0.010287819,
-0.022467652,
0.022388818,
0.022099761,
0.0041059307,
-0.010944769,
0.009433786,
0.0032321885,
-0.019931829,
-0.023952356,
-0.05308147,
0.0060932008,
-0.015898162,
0.0023370956,
0.022204872,
0.009598023,
-0.024083747,
-0.02376841,
0.004125639,
-0.0058172825,
-0.007949081,
-0.003869429,
0.010721406,
-0.0154120205,
-0.017960982,
0.04162428,
-0.00028618335,
-0.009749121,
0.011233826,
-0.0022533347,
-0.0039548324,
0.0030038988,
-0.008717712,
-0.01697556,
0.023400519,
-0.0021367262,
-0.010156429,
-0.021285145,
0.01849968,
-0.001111886,
0.007081909,
0.041177556,
-0.005189896,
-0.023873523,
-0.015687939,
-0.047878437,
0.02185012,
-0.00540012,
0.008041054,
0.010005332,
-0.0056826076,
0.0030958715,
-0.008362959,
-0.0043522865,
-0.018815016,
0.0065891976,
-0.007949081,
-0.0036723444,
-0.011286382,
-0.028248802,
-0.017461702,
0.029615255,
-0.010057887,
0.012955032,
0.0344504,
-0.007633746,
-0.007206729,
0.007633746,
0.008435223,
-0.029983148,
-0.018815016,
-0.032847445,
0.015740495,
-0.03263722,
-0.009289257,
-0.001658796,
-0.037078194,
-0.0021252297,
0.019235464,
0.0076468852,
-0.021547923,
0.012009026,
0.01451857,
0.008494349,
0.022007788,
-0.047957268,
-0.027802076,
0.027329074,
0.010248403,
0.0018558806,
-0.002475055,
-0.049560223,
-0.00057688326,
0.002634365,
-0.014912739,
0.015017851,
0.0043227235,
0.014873323,
-0.010649142,
-0.005653045,
-0.033346724,
-0.012107568,
0.010984185,
-0.010438918,
-0.006963658,
0.02430711,
-0.0017589807,
0.0031221495,
-0.007554912,
-0.0060636383,
-0.011384924,
-0.021942092,
0.014058706,
-0.0055840653,
-0.036473803,
-0.019196047,
0.017317172,
0.0377877,
0.01810551,
0.007502356,
0.004398273,
-0.014098123,
0.002846231,
-0.014242652,
0.017816454,
0.033740893,
0.0024159295,
-0.011995886,
-0.0065891976,
0.014663099,
-0.006309994,
-0.009118451,
0.015898162,
0.018723043,
0.011529453,
0.0035672325,
0.024018051,
0.0010346945,
0.012751378,
0.024780111,
0.033083946,
-0.009322105,
-0.0040796525,
0.009906789,
0.027854633,
0.008014777,
0.012495168,
0.009216993,
-0.01848654,
0.004720178,
0.05050623,
-0.040178996,
-0.037446085,
-0.014308346,
0.023072045,
0.0038070187,
-0.0052260286,
-0.011844789,
0.004651198,
-0.002854443,
0.0020710314,
0.013979873,
-0.0118185105,
-0.0031402158,
0.030692652,
0.0027920327,
0.0014477511,
-0.008796546,
-0.002943131,
0.0030548123,
-0.008632309,
0.054027475,
-0.035028514,
0.004378564,
-0.024661861,
0.023058906,
-0.0023765126,
-0.044252075,
-0.0138879,
0.00094846997,
-0.0049008387,
-0.011995886,
0.0020316145,
-0.005564357,
0.07158115,
0.014190096,
0.0011784021,
-0.010714836,
-0.019209186,
0.02969409,
-0.01234407,
0.03132332,
-0.009302396,
-0.018617932,
0.028616693,
-0.03318906,
0.04023155,
-0.031559825,
-0.045592252,
0.0075220647,
-0.024504194,
-0.0016670078,
-0.008849101,
-0.028064856,
0.015228075,
-0.029588979,
0.008579752,
0.013480592,
-0.031165656,
-0.008809685,
0.021692453,
0.0021679313,
-0.0014617112,
0.0024290686,
0.010773961,
-0.014479154,
-0.04743171,
-0.00115623,
0.006480801,
-0.025423922,
0.009985623,
-0.023479354,
-0.0017425569,
0.007949081,
0.008941074,
0.017895287,
-0.01874932,
-0.01221268,
0.02751302,
-0.005997943,
-0.031191934,
-0.00071730604,
-0.033136502
] |
Most multiple case families of young onset breast cancer and ovarian cancer are thought to be due to highly penetrant mutations in the predisposing genes BRCA1 and BRCA2. However, these mutations are uncommon in the population and they probably account for only a few percent of all breast cancer incidence. A much larger fraction of breast cancer might, in principle, be due to common variants which confer more modest individual risks. There are several common polymorphisms in the BRCA1 gene which generate amino acid substitutions. We have examined the frequency of four of these polymorphisms: Gln356Arg, Pro871Leu, Glu103 | [
-0.015029494,
-0.0071609574,
-0.014924667,
-0.04706708,
-0.023232164,
0.021423908,
-0.017859807,
0.009951962,
-0.031998277,
-0.0051495996,
0.006433724,
-0.005752352,
0.009676793,
0.015684659,
-0.022485275,
0.015199836,
0.04064646,
0.0012415384,
0.007966811,
-0.00792095,
-0.031788625,
0.016339824,
0.0011637375,
0.0026010065,
0.0008066724,
0.018986693,
0.017335676,
-0.031788625,
-0.0037737526,
-0.0074033686,
0.02198735,
0.0182267,
-0.01117057,
0.009847135,
-0.0051790825,
0.031081045,
0.0100829955,
-0.012782277,
0.011059191,
-0.030242434,
-0.002556783,
0.016470857,
0.0078816395,
-0.004710639,
-0.024175603,
-0.0031595351,
0.023205958,
0.0069709597,
-0.021672871,
-0.0012980464,
-0.012703656,
0.029298995,
-0.027228672,
0.0062568295,
-0.015632246,
-0.013326064,
0.0071609574,
0.022197003,
0.004422366,
0.0020883395,
0.0010433509,
0.00038163384,
-0.016824646,
0.013293305,
-0.018082565,
0.028748658,
0.0049432227,
0.01628741,
-0.00056344224,
0.0032872923,
0.046071228,
0.03569341,
-0.02547283,
-0.011412981,
0.0061061415,
-0.0186198,
-0.013247444,
0.0022586826,
-0.02563007,
0.006794065,
0.004563227,
0.0056311465,
0.011596427,
0.0036951327,
0.010410578,
0.0080323275,
0.0077702613,
0.0069382014,
0.002985916,
0.0033249643,
0.017754981,
0.006741652,
-0.0039146133,
-0.000983567,
0.00058801094,
0.006682687,
-0.007737503,
0.024974905,
0.013443993,
-0.015160527,
-0.0021030807,
0.009552311,
0.002479801,
-0.012015733,
-0.04227127,
-0.009041282,
0.0023176474,
0.0010245149,
0.010109202,
0.0008689131,
-0.013057446,
0.0305045,
-0.005716318,
-0.0042421957,
0.04172093,
-0.02392664,
0.021096325,
-0.01010265,
-0.018724626,
0.0045533995,
0.02678316,
0.016850853,
-0.0014831306,
-0.00088856806,
0.008490943,
-0.0035346171,
-0.03731822,
0.0057064905,
-0.006125796,
-0.009106799,
0.021240462,
-0.0067875134,
0.021148738,
0.014479155,
-0.014099159,
-0.0013136066,
-0.028014872,
-0.021410804,
-0.018318424,
-0.023599057,
0.01006334,
0.03917889,
-0.015619143,
0.022721136,
-0.012526762,
0.023140442,
0.009323004,
0.0014339932,
-0.0088316295,
-0.003141518,
0.007357507,
0.0088840425,
0.014688808,
-0.017610846,
0.010947813,
-0.0063682073,
-0.006115969,
0.0070233727,
-0.05039532,
-0.030006574,
0.014308812,
0.015815692,
0.0067678583,
0.040908527,
0.013535717,
0.02095219,
0.017951531,
-0.0067678583,
0.0017361882,
-0.011105053,
-0.012480901,
0.016628098,
-0.027464533,
0.008412323,
-0.0025846274,
0.017558431,
-0.0056933872,
-0.00078497,
-0.021554941,
-0.0067875134,
-0.016182585,
0.0028729,
0.027936252,
0.005808041,
-0.022747342,
0.000983567,
0.009991272,
-0.0147412205,
-0.012480901,
-0.03150035,
-0.0031103976,
0.010594024,
0.023035614,
-0.024057673,
-0.63482904,
-0.020965291,
-0.01025989,
-0.002063771,
0.0112360865,
0.034566525,
0.017637052,
-0.0023438542,
-0.031081045,
0.018357733,
-0.016510168,
0.020572193,
0.008222326,
-0.011910906,
-0.012788828,
-0.044105735,
0.013968126,
-0.019943234,
0.027438326,
0.0055525266,
-0.016929474,
0.01366675,
-0.00007585587,
0.014963977,
0.016234998,
0.017846705,
0.0008476202,
-0.026481785,
0.032443788,
0.031421732,
-0.023743194,
0.020231506,
-0.008124051,
0.010096098,
0.038838204,
-0.0035608239,
0.00024056854,
0.03304654,
0.028617624,
0.021934938,
0.014557774,
0.018030152,
0.0364534,
-0.0020588571,
-0.012867448,
0.03792097,
0.0070102694,
-0.0020719606,
0.01244159,
-0.008929904,
0.0037442702,
0.0217908,
-0.026560403,
-0.037187185,
0.0182267,
-0.009224729,
0.031002425,
-0.028014872,
0.0018737729,
-0.008510598,
-0.005015291,
0.030635534,
-0.009768516,
-0.021266667,
0.0064107934,
0.0053297705,
-0.012742966,
0.022956995,
-0.015606039,
-0.013994332,
0.033098955,
0.04132783,
-0.010397474,
-0.011681599,
0.036898915,
0.037763733,
-0.010744712,
0.018488767,
-0.008255084,
0.019340482,
0.014125366,
-0.0060897623,
-0.04785328,
0.0045501236,
0.020375643,
0.004163576,
0.004481331,
0.018121874,
-0.008209222,
-0.0074819885,
0.026167305,
-0.0059357984,
-0.011622634,
-0.015448799,
-0.0111378115,
0.00062936824,
-0.010633334,
0.01838394,
-0.008051982,
-0.027202467,
-0.033465847,
-0.009178867,
-0.0074885404,
0.0011899441,
0.026023168,
-0.019327378,
0.00086973206,
0.0061552785,
0.020781845,
-0.011164018,
-0.00084516336,
-0.0061716577,
0.010056788,
-0.012061595,
0.00003918196,
-0.019445308,
-0.013810886,
0.00025490028,
-0.005300288,
-0.014072952,
0.0036754778,
0.031710003,
-0.011308154,
-0.03616513,
0.036898915,
-0.00481219,
0.00032901586,
-0.014937771,
0.026992813,
-0.013535717,
0.028696243,
-0.024568701,
-0.00303014,
-0.03252241,
0.00272385,
-0.015632246,
0.024621114,
0.0065614814,
0.008510598,
-0.009729206,
-0.024581805,
-0.011281948,
0.021253565,
0.0047761556,
-0.016641201,
0.0089823175,
-0.048508443,
-0.012002629,
-0.0072199223,
0.009709551,
0.019445308,
0.0032774648,
0.009205073,
0.014243295,
0.0101354085,
0.0021227358,
0.014374329,
-0.00058268773,
0.01037782,
0.0012439953,
0.027045228,
-0.010004375,
-0.0091854185,
-0.024280429,
0.0106857475,
-0.021659767,
-0.0019147209,
0.0112360865,
-0.005696663,
-0.03938854,
-0.0020392023,
-0.019353585,
-0.0008083103,
0.015147423,
-0.011222983,
0.021934938,
-0.02523697,
-0.0053428737,
0.0066302735,
-0.010567818,
-0.008418875,
-0.039755434,
-0.018881867,
-0.009676793,
0.035798237,
0.0233763,
0.03600789,
-0.016562581,
0.00423892,
0.024856973,
-0.0269404,
0.023834916,
-0.003215224,
0.014086056,
0.008608873,
-0.017794292,
0.024476979,
0.030242434,
-0.008530254,
0.02809349,
0.026416268,
-0.0023160095,
0.038890615,
-0.014885358,
0.02226252,
-0.04924223,
0.009401623,
0.0032823784,
0.002232476,
0.00097619643,
-0.0065418263,
0.03700374,
0.0018770488,
0.0060013146,
-0.00170343,
0.002286527,
0.005883385,
-0.0032709131,
0.024647322,
-0.0102336835,
-0.0155929355,
0.031185871,
0.040698875,
0.0026059202,
-0.0045173652,
0.016090862,
0.020794949,
-0.0006338725,
0.014846047,
-0.0034559974,
-0.0010744712,
0.019432206,
-0.00012652882,
0.029298995,
0.013653646,
-0.0042127133,
0.0020113578,
-0.00744923,
0.013411235,
-0.01671982,
-0.008222326,
-0.00022500836,
-0.005260978,
0.020794949,
0.026573507,
-0.0081830155,
0.034959625,
0.0083861165,
-0.006898891,
0.00060602796,
-0.01572397,
-0.0050611524,
-0.008694044,
0.021607354,
-0.0017754982,
-0.012474349,
0.037973385,
0.035221692,
0.045337442,
0.02108322,
0.02396595,
-0.013358822,
0.0026337649,
0.008870939,
-0.009047834,
0.014256398,
-0.000018375342,
0.0039473716,
0.0032774648,
0.003557548,
-0.030216226,
-0.025787309,
0.022511482,
-0.030058987,
-0.0027910045,
-0.00344617,
0.0003427334,
0.022786653,
-0.0010842987,
0.014937771,
-0.027962457,
-0.036505815,
0.032784477,
0.047250528,
-0.014688808,
-0.008949559,
-0.0047990866,
-0.0037540975,
0.008805423,
0.0010327044,
0.015946725,
0.018174287,
-0.015776383,
0.012998481,
0.01097402,
0.023520436,
0.018868763,
-0.017165333,
-0.007095441,
-0.0033216884,
-0.00043773238,
-0.018894969,
-0.008019224,
0.007344404,
0.018763937,
0.037501667,
-0.008307497,
-0.020061163,
-0.010626783,
-0.033020336,
-0.0037409943,
-0.022590103,
-0.002836866,
-0.012526762,
-0.00280247,
-0.00024630124,
0.034147218,
0.0052511506,
-0.0017165333,
0.0045337444,
-0.0064632064,
-0.031762417,
-0.015868105,
0.0105350595,
0.018030152,
0.0217908,
-0.018200494,
0.014479155,
0.019707374,
0.02024461,
-0.01382399,
-0.0015633884,
0.020650813,
-0.004084956,
-0.014020539,
-0.00412099,
0.02488318,
0.016248101,
0.010227132,
0.032024484,
0.0062502776,
-0.040960938,
-0.0016690338,
-0.0063845864,
-0.010397474,
-0.0007767804,
0.039834056,
0.03275827,
0.025459727,
-0.00950645,
0.013850196,
0.025276281,
0.024306636,
0.004818741,
-0.01993013,
0.0026992813,
0.0056278706,
0.033308607,
0.024083879,
-0.016208792,
0.0069382014,
0.00556563,
-0.019353585,
-0.006568033,
0.0074623334,
-0.013679853,
0.014125366,
0.02241976,
0.020768743,
0.0031169492,
-0.005133221,
-0.006286312,
0.01993013,
-0.025210764,
-0.017637052,
-0.019419102,
-0.028250732,
-0.033020336,
0.01640534,
0.0016305428,
-0.011760218,
-0.019392895,
-0.006450103,
-0.018121874,
-0.0087137,
-0.014190882,
-0.023323888,
0.00295152,
0.014033643,
-0.011399877,
-0.015920518,
-0.009696447,
-0.019091519,
-0.028434178,
-0.013457097,
-0.026481785,
-0.013797782,
-0.027700393,
0.02880107,
0.021685975,
0.004176679,
-0.0055164923,
0.015278457,
0.036269955,
-0.00043486603,
-0.012697105,
-0.011445739,
-0.030792773,
0.017912222,
0.022760445,
0.004595985,
-0.033308607,
-0.025027318,
0.027228672,
-0.0075671603,
-0.014623291,
0.004959602,
0.00344617,
0.0053985626,
0.026376957,
-0.0016133448,
0.010404026,
-0.00054255885,
-0.011602979,
0.0101354085,
-0.018593593,
-0.03422584,
-0.02880107,
-0.021672871,
-0.009159212,
0.001854118,
0.0010130495,
0.00820267,
-0.014715014,
0.0027877286,
-0.008379566,
0.015579833,
-0.0032070344,
-0.009237831,
0.028172111,
-0.0094867945,
-0.0063485526,
0.0008152714,
-0.00336755,
0.027464533,
0.0011629185,
0.032260343,
-0.013719163,
-0.020860465,
-0.000719044,
-0.013758473,
-0.012860896,
-0.010672644,
-0.0030989323,
0.000005262437,
0.03427825,
0.008045431,
-0.03708236,
0.0025223866,
-0.0025977306,
-0.0022062694,
-0.0047794315,
-0.004861327,
-0.0072723357,
-0.02353354,
0.01525225,
0.006794065,
-0.034356873,
0.009558863,
-0.02840797,
-0.0007653151,
0.0014634756,
-0.011917458,
0.006604067,
-0.002324199,
0.005129945,
-0.01339158,
-0.023939744,
-0.017794292,
-0.005280633,
0.011629186,
-0.00776371,
0.037737526,
0.02725488,
0.025957651,
0.0016723096,
0.012474349,
0.029377615,
0.024739044,
0.0026927297,
-0.017781189,
0.0012538227,
-0.0058014896,
0.023140442,
0.004314264,
0.022878375,
0.034121014,
-0.014662601,
0.029534856,
0.021463217,
-0.019589445,
-0.023782503,
-0.015501212,
-0.053618733,
-0.03383274,
-0.0017345503,
-0.026468681,
0.03189345,
-0.0427954,
0.024594909,
0.016746027,
0.0019753235,
0.008418875,
-0.016981887,
0.02468663,
-0.0008877491,
0.0051725307,
-0.006807168,
-0.0026173857,
-0.02361216,
-0.037580285,
-0.006587688,
0.0057032146,
-0.0036230646,
-0.014112262,
0.029377615,
0.003220138,
-0.021148738,
0.0080847405,
-0.0030170365,
-0.041354038,
-0.0150557,
0.001646922,
-0.0032463444,
-0.0147412205,
-0.007141303,
0.0046909843,
-0.023389405,
-0.012985378,
0.01552742,
-0.022157693,
0.021319082,
0.0042880573,
-0.02404457,
-0.0007059407,
-0.0010802039,
0.024490083,
-0.024319738,
0.030792773,
-0.0011842115,
-0.0068202717,
-0.004261851,
-0.009067489,
-0.00029666707,
0.014544671,
0.032103103,
0.018777039,
0.010253338,
0.01010265,
0.0001922501,
-0.023952845,
-0.04575675,
-0.004032543,
0.022288727,
-0.009296796,
0.016510168,
-0.0090871435,
-0.010705402,
-0.0077964677,
0.006456655,
-0.013417787,
0.01885566,
-0.009781619,
-0.027123846,
-0.0102336835,
0.009545759,
-0.017466709,
0.003950647,
0.0036623743,
-0.021974247,
0.0009630931,
-0.014112262,
0.016890163,
0.011439187,
-0.009676793,
0.027779011,
0.0064107934,
-0.0063321735,
-0.003518238,
-0.0015969656,
-0.0039899573,
-0.0039899573,
-0.006643377,
0.048796717,
-0.0039309924,
0.001721447,
0.0030366916,
-0.003423239,
0.010469543,
0.01521294,
-0.00760647,
-0.007233026,
-0.024870077,
-0.0020654087,
0.020270817,
0.010502301,
-0.015160527,
-0.0011031347,
-0.024201808,
0.0026992813,
-0.027831426,
-0.036872707,
0.014203985,
-0.038445104,
-0.009689895,
-0.010882297,
0.02349423,
0.014806737,
0.03375412,
-0.0059161433,
-0.021358391,
0.039519574,
-0.006509068,
-0.022249416,
0.0035280655,
-0.010725057,
-0.022642516,
0.021266667,
-0.010155063,
0.0004885077,
0.018528076,
-0.014269502,
0.005657353,
-0.03105484,
-0.0007436127,
-0.003293844,
0.015265353,
-0.017925324,
0.0050054635,
0.01525225,
0.020821156,
-0.013692956,
-0.019432206,
0.005955453,
-0.012782277,
0.017977739,
0.0022292002,
0.015081907,
-0.013561923,
-0.02809349,
-0.0088316295,
0.0034199632,
0.0045894333,
0.0057818345,
0.01489846,
-0.00427823,
0.0095326565,
0.007003718,
-0.0018229977,
-0.006224071,
-0.027438326,
0.012887103,
0.021201152,
-0.0013783042,
-0.0126381405,
0.020100474,
-0.003180828,
0.020899776,
-0.031526558,
0.0016190774,
-0.015514316,
-0.021528734,
-0.016457755,
-0.00060439005,
-0.017401192,
0.028434178,
0.040672667,
-0.0015592936,
-0.028565211,
-0.022786653,
-0.031788625,
-0.016470857,
0.0033266023,
0.013758473,
0.0041537485,
0.037658907,
0.0016174396,
0.026861781,
-0.0037180635,
0.013863299,
-0.024725942,
0.020113576,
-0.0017951531,
-0.017073609,
0.017925324,
0.013057446,
-0.02063771,
-0.0087333545,
0.022904582,
0.015396386,
-0.020978395,
0.021895627,
-0.035012037,
0.02539421,
-0.024096983,
0.0013717525,
0.0033364296,
0.034592733,
0.022825962,
-0.021319082,
-0.022590103,
-0.003025226,
0.009657138,
0.007665435,
-0.00012376484,
-0.026494889,
0.021974247,
0.017401192,
-0.008621977,
-0.01715223,
0.02012668,
-0.01548811,
-0.002992468,
0.027857631,
0.017872911,
0.01830532,
0.010266442,
0.0051561515,
-0.00009172315,
-0.032548618,
-0.007043028,
-0.0007501643,
-0.0063911383,
-0.008589218,
-0.027385913,
-0.010312303,
-0.02511904,
-0.011871597,
-0.013168824,
0.0061651063,
-0.027700393,
-0.024214912,
0.035667203,
-0.00915266,
-0.002630489,
0.008753009,
0.007599918,
-0.026481785,
-0.005883385,
-0.038340278,
0.010633334,
-0.0112360865,
0.010672644,
0.0023405782,
-0.017322572,
0.0022586826,
-0.000011810891,
-0.008746458,
-0.020192197,
0.005791662,
0.1838656,
0.00051021005,
-0.012349867,
0.026992813,
0.01105264,
-0.011524359,
0.017335676,
0.0067678583,
0.0069513046,
0.0022701481,
0.015409489,
0.0040816804,
-0.014256398,
0.0018262735,
0.023559747,
-0.0073902654,
-0.045337442,
-0.005333046,
-0.028905896,
0.014701911,
0.011976423,
-0.013181928,
-0.019078415,
-0.010371268,
0.0202053,
0.020598399,
-0.009650586,
-0.016038448,
0.012323661,
-0.023507334,
-0.01362744,
-0.011406429,
-0.0036296162,
0.0017181712,
-0.027045228,
-0.0034854799,
0.008012673,
-0.020899776,
0.0053658043,
-0.0021817007,
-0.014269502,
0.054404933,
-0.02071633,
-0.018777039,
-0.021581147,
0.008425427,
0.011288499,
-0.0124874525,
-0.0066368254,
-0.013732267,
-0.0336755,
0.022590103,
0.0044420213,
0.0050414978,
-0.007940604,
-0.005598388,
0.024214912,
0.0016690338,
-0.015448799,
0.01358813,
0.0043208157,
-0.005713042,
-0.041773345,
0.02051978,
-0.018777039,
0.025590759,
-0.024516288,
0.01723085,
0.017584639,
-0.029456235,
-0.014872254,
-0.017414296,
-0.007626125,
0.024254221,
0.00061339856,
-0.014243295,
0.017925324,
0.013247444,
0.0041471967,
-0.005434597,
0.01885566,
0.0065713087,
-0.021043912,
-0.029613474,
-0.024149396,
-0.02435905,
0.00911335,
0.0044158148,
0.013561923,
0.001701792,
-0.009342658,
-0.0076195733,
0.0054018386,
-0.0010081357,
-0.006833375,
0.013063998,
-0.016261205,
0.018803246,
-0.02369078,
-0.022996305,
-0.02435905,
0.04698846,
0.0039244406,
0.009729206,
-0.012513659,
0.0051495996,
0.010155063,
0.023035614,
0.005739249,
0.0018623075,
-0.0023438542,
-0.022301828,
-0.009060937,
-0.015619143,
-0.003976854,
0.001343908,
0.015343973,
-0.020886673,
0.007960259,
-0.0062470017,
-0.014937771,
-0.03894303,
0.005899764,
0.045153998,
0.011340912,
0.0076523316,
-0.013306409,
-0.0070233727,
0.001532268,
-0.038995445,
0.00776371,
-0.0056901113,
-0.014099159,
0.0028876413,
-0.013758473,
-0.015304663,
0.0089364555,
-0.035012037,
-0.01014196,
0.003557548,
-0.016234998,
-0.007075786,
0.0061716577,
0.010751264,
-0.024673527,
-0.024817664,
-0.0074688853,
0.0058506266,
-0.0043240916,
0.019510824,
-0.035169277,
-0.01366675,
-0.015999138,
0.015108113,
0.013692956,
-0.014217089,
-0.02880107,
-0.03490721,
-0.007750606,
0.03364929,
-0.016182585,
0.014361225,
0.034094807,
-0.011557117,
0.003521514,
-0.0022046315,
-0.1636341,
0.0113867745,
0.010174719,
-0.022930788,
0.014479155,
0.0035935822,
0.014033643,
-0.019170139,
0.014282606,
-0.017270159,
0.028250732,
-0.01252021,
-0.020598399,
-0.013601233,
0.005732697,
-0.013430891,
-0.023507334,
0.056396637,
0.016431548,
-0.0008443444,
0.018410146,
-0.035195485,
0.027700393,
-0.0052544265,
-0.013378477,
0.004045646,
-0.00536908,
0.0061585545,
-0.014649497,
-0.012769173,
0.0017574811,
0.008327152,
0.026127996,
-0.033334814,
0.01271676,
-0.0013455459,
-0.012644691,
0.0073378524,
-0.0033806534,
-0.018056357,
0.040698875,
0.04662157,
0.017492916,
0.017414296,
-0.0077178483,
0.015566729,
0.031762417,
-0.019235656,
0.013293305,
0.027045228,
0.011570221,
0.023035614,
0.027700393,
-0.0030448812,
0.004183231,
-0.008215774,
0.012978826,
-0.0009901187,
0.0041701277,
-0.01366675,
-0.0060013146,
-0.03933613,
0.049976014,
0.0017558432,
-0.015278457,
-0.008097844,
-0.032338962,
0.019707374,
-0.03430446,
0.013614336,
-0.015553626,
-0.0033528088,
0.015029494,
-0.017964635,
0.010679196,
0.0016534736,
-0.0063092425,
0.0023602333,
0.0000010796792,
-0.006260105,
-0.021856317,
0.00681372,
-0.03105484,
-0.009172316,
-0.009519553,
0.0008623614,
0.005660629,
0.02024461,
0.002140753,
-0.022328036,
0.018030152,
-0.022000453,
-0.0074033686,
-0.02504042,
0.010109202,
0.009408175,
0.002157132,
-0.019602548,
0.004258575,
-0.007396817,
-0.0025879033,
-0.031841036,
-0.028224524,
0.01683775,
0.04654295,
-0.018763937,
0.004864603,
0.008628528,
0.058178686,
-0.029298995,
0.004507538,
0.01525225,
-0.0020883395,
0.00518891,
-0.019523928,
0.02226252,
-0.0068399264,
0.015108113,
0.008766113,
0.00016307476,
0.049897395,
0.008006121,
0.01885566,
-0.021777697,
0.018213598,
0.003537893,
-0.10985813,
-0.014924667,
0.01025989,
0.014662601,
-0.014793634,
-0.00088283536,
-0.016221894,
0.03700374,
-0.02701902,
0.04869189,
-0.004409263,
-0.012526762,
-0.0046909843,
0.0074819885,
-0.004261851,
-0.012900206,
0.005880109,
-0.01160953,
-0.02701902,
0.019497722,
-0.0027795392,
0.008196119,
0.012801931,
-0.010613679,
-0.005811317,
-0.025105936,
-0.05343529,
-0.0025207489,
-0.0007939785,
0.0026779885,
0.006070107,
-0.013142617,
0.004658226,
-0.011570221,
-0.028303144,
-0.002293079,
-0.009571966,
-0.029534856,
0.016444651,
-0.0015224406,
-0.0036689262,
0.0053428737,
0.016248101,
0.004314264,
0.00582442,
-0.011406429,
-0.030216226,
0.014911564,
0.013928816,
-0.016169481,
-0.012290902,
-0.0038163383,
-0.035667203,
-0.015383283,
-0.0018459285,
-0.036479607,
-0.00089757657,
0.028119698,
0.010462991,
-0.008707148,
0.002915486,
0.00481219,
-0.020192197,
0.015409489,
0.041144386,
-0.024608012,
-0.01022058,
-0.03034726,
0.011891251,
-0.014256398,
-0.0012497279,
0.00627976,
-0.0075606084,
0.005185634,
-0.024070775,
0.003727891,
-0.01754533,
-0.00094671396,
0.018606696,
-0.038995445,
-0.00028724907,
-0.0010679195,
0.02032323,
-0.01865911,
0.01184539,
0.024254221,
0.012985378,
-0.0045337444,
-0.008897146,
-0.020729432,
-0.020899776,
0.053723563,
-0.018868763,
-0.023074925,
-0.024621114,
0.01101333,
-0.008766113,
-0.008576115,
0.015855001,
0.039257508,
-0.029875541,
-0.013679853,
-0.045782957,
0.027045228,
0.004261851,
-0.017021196,
0.013286754,
0.0040194397,
0.0046287435,
-0.004746673,
-0.006564757,
0.033177573,
0.009290245,
0.0336755,
-0.01521294,
-0.023363197,
-0.0048154653,
-0.009539207,
0.0060864864,
0.011707805,
0.026992813,
0.029639682,
0.0017247228,
0.0007272336,
0.02380871,
0.0007591729,
-0.026835574,
-0.017283263,
-0.014151572,
0.033518262,
-0.024909388,
0.00010431461,
0.0029449684,
-0.030137608,
-0.021803904,
-0.0015429144,
-0.0030366916,
-0.028250732,
0.006528723,
0.0042454717,
0.036977533,
0.024830768,
-0.011485049,
-0.027779011,
0.013902609,
0.005595112,
-0.003370826,
0.0042454717,
-0.044603657,
0.007508195,
-0.00096391205,
0.010639885,
0.017361883,
-0.0031693624,
0.008078189,
-0.04465607,
-0.013522614,
-0.0019982543,
-0.009447484,
-0.010790573,
-0.014335019,
-0.029534856,
0.0305045,
0.0045402963,
0.010390922,
-0.014479155,
-0.0057654553,
-0.01818739,
-0.015226044,
0.012552968,
0.0036754778,
-0.035326518,
-0.002632127,
0.0011211517,
0.015475006,
0.023703882,
0.0051692547,
-0.0102860965,
-0.013601233,
0.0032774648,
0.018397044,
0.017820498,
-0.0056180432,
0.025970755,
-0.007226474,
0.026796265,
0.023834916,
0.002910572,
-0.004274954,
-0.011511256,
0.017008092,
0.025158351,
0.013306409,
0.018829454,
0.017781189,
-0.0008197757,
0.0057032146,
-0.0024748873,
0.00027394103,
0.0022439414,
0.009178867,
0.033492055,
0.01640534,
-0.007383714,
-0.01354882,
-0.013011584,
-0.025158351,
0.0021473046,
-0.035562377,
-0.028591417,
-0.020978395,
0.0026075582,
0.016313618,
0.019301172,
0.0037475459,
-0.011727461,
0.00070266484,
0.0004332281,
0.0025240246,
-0.013404683,
-0.006984063,
0.02384802,
0.005221668,
0.017859807,
0.005804765,
0.017492916,
0.007305094,
0.005696663,
0.030137608,
-0.019497722,
0.014715014,
-0.011504704,
0.029770715,
-0.019510824,
-0.02341561,
-0.0038851306,
-0.0013316236,
-0.018908072,
0.009755412,
0.010947813,
-0.025053523,
0.08228877,
0.0046451227,
0.005808041,
0.014400535,
-0.020794949,
0.028434178,
0.01810877,
-0.006794065,
-0.0062371744,
-0.023454921,
-0.0057687312,
-0.026887987,
-0.0013340805,
-0.02555145,
-0.018488767,
0.015855001,
-0.002573162,
-0.000091671965,
-0.012887103,
-0.027490739,
0.01869842,
0.0014053297,
0.011164018,
0.023677677,
-0.024542496,
-0.0027877286,
0.016746027,
0.018894969,
0.0064107934,
-0.01648396,
-0.005270805,
-0.014583982,
-0.027045228,
-0.0144398445,
0.017938428,
-0.02384802,
0.013876403,
-0.02606248,
0.002707471,
0.013063998,
0.0011522721,
-0.017217746,
-0.016326722,
-0.02717626,
0.014177779,
-0.005788386,
-0.0034134116,
-0.028381765,
-0.005729421
] |
Nitric oxide (NO) is produced in the vascular endothelium and is a potent vasodilator substance that participates in the regulation of local vascular tone. Exercise causes peculiar changes in systemic and regional blood flow, i.e., an increase of systemic blood flow and a redistribution of local tissue blood flow, by which the blood flow is greatly increased in the working muscles, whereas it is decreased in some organs such as the kidney and intestine. Thus we hypothesized that exercise causes a tissue-specific change of NO production in some internal organs. We studied whether exercise affects expression of NO synthase (NOS) mRNA and protein, NOS | [
-0.029410195,
-0.032635335,
0.0016877586,
-0.01279817,
-0.016548034,
0.015844135,
-0.028770287,
-0.014986657,
-0.02623625,
0.003020368,
-0.0076405075,
-0.0037978569,
-0.0046073413,
0.0188901,
-0.013022138,
-0.0033883154,
0.03209781,
-0.01405239,
0.013284501,
-0.027311295,
-0.0057879724,
0.028002396,
0.0013318096,
-0.0009854591,
-0.012190257,
0.013386886,
0.019593999,
-0.035194967,
0.0110832155,
-0.035118178,
0.009707412,
0.013732436,
-0.03440148,
-0.017840648,
0.0067702318,
0.016842391,
-0.026517808,
-0.0038842445,
0.0028907866,
-0.00067790307,
0.025493955,
-0.0020029135,
-0.00068350224,
-0.0051352656,
-0.018710924,
0.006027938,
0.014628308,
0.0016909582,
-0.0078004845,
0.031201938,
0.027464872,
-0.008101242,
0.021347348,
0.01734152,
-0.012228651,
-0.015818538,
-0.012177459,
0.004021825,
-0.0111344075,
-0.018659731,
-0.01776386,
0.0071285805,
-0.03176506,
0.007282159,
-0.030024506,
-0.00293718,
0.0026780171,
0.031483497,
-0.0014437935,
0.0050872727,
0.018160604,
0.034734234,
-0.010763261,
0.018198997,
0.017149547,
-0.016138492,
-0.04049341,
-0.01630487,
-0.009201884,
-0.0008430794,
0.03222579,
-0.027311295,
-0.025289183,
0.03711469,
0.022857532,
-0.017815052,
0.006866218,
0.0096946135,
-0.015549776,
0.0064374795,
0.030050103,
0.02153932,
0.017994227,
0.00041314092,
-0.011851105,
0.026185056,
-0.01923565,
0.028539918,
-0.005784773,
-0.015153033,
-0.015127437,
-0.014986657,
-0.013156518,
-0.009995371,
-0.024482898,
0.009502641,
-0.007461333,
-0.016637621,
0.01727753,
-0.014973858,
-0.030920379,
0.02685056,
-0.011339178,
-0.030459644,
0.015920924,
-0.00054472213,
0.025980284,
-0.0033947146,
-0.0042489925,
-0.01782785,
-0.011985486,
0.01650964,
0.026466615,
-0.013950005,
0.011716724,
0.016381657,
-0.0043929718,
0.019683585,
-0.015396198,
-0.010737664,
-0.007083787,
-0.00036474783,
-0.0034043132,
0.004581745,
-0.026069872,
0.01936363,
-0.008830737,
0.013489271,
-0.0061975135,
-0.03818974,
-0.0015821737,
0.01622808,
-0.039341573,
0.011665531,
-0.019568402,
0.040186252,
0.033428818,
0.018864503,
0.043744143,
0.006795828,
0.0038714465,
-0.0049464926,
0.007845278,
-0.02091221,
0.004610541,
0.016240878,
-0.012017482,
0.034299094,
0.004559348,
-0.021347348,
0.021628907,
-0.009400256,
0.026313037,
-0.014410739,
-0.0006591058,
0.0033723176,
0.008529981,
0.00041993996,
-0.010552091,
-0.005784773,
-0.004421768,
0.027541662,
-0.024226936,
0.018301383,
0.009182687,
0.041389283,
0.010526495,
0.030817993,
0.016893584,
-0.0021500925,
-0.0029851731,
0.016931979,
0.040467814,
0.000052142543,
-0.0052824444,
-0.0016069702,
0.04228515,
-0.029819736,
0.021296155,
-0.008696357,
-0.021552118,
0.011780716,
-0.036679555,
-0.030587627,
-0.6433896,
-0.0053816303,
0.002497243,
-0.012145463,
0.02335666,
0.021500925,
-0.00005279245,
0.0018349376,
-0.017955832,
0.01993955,
-0.022895927,
0.03063882,
0.011255991,
-0.026645789,
-0.009099498,
-0.03650038,
-0.010078559,
-0.0019357232,
0.018992484,
-0.017328722,
-0.0042969855,
-0.023049504,
0.022422394,
0.023471843,
0.020246705,
0.04300185,
-0.000678303,
-0.0121518625,
-0.008958719,
0.015485786,
0.018211795,
0.009093099,
0.012529409,
0.024700468,
0.043539375,
-0.012407825,
-0.005202456,
0.0066806446,
-0.013681243,
0.016740005,
-0.02244799,
0.008338008,
0.02257597,
-0.0076661035,
-0.0020029135,
0.005048878,
0.027362486,
-0.018378172,
0.0033467214,
-0.002615626,
0.005468018,
-0.010468903,
-0.007870874,
0.034273498,
-0.0033659188,
0.012478216,
0.019286841,
0.008382801,
-0.013527665,
0.0181734,
-0.004322582,
0.020925008,
-0.02188487,
-0.013745234,
0.024879642,
0.014564318,
-0.043948915,
0.009093099,
0.008997113,
0.014794684,
0.015959319,
0.031201938,
0.0056727887,
-0.026824964,
0.033249646,
0.027541662,
0.0068406216,
0.012593399,
-0.02434212,
0.008651563,
-0.0195812,
0.021833679,
-0.015306612,
0.0050104833,
0.03795937,
0.002300471,
-0.021372944,
0.025122808,
0.009285072,
-0.008869132,
0.024380514,
0.014551519,
-0.045791853,
-0.030050103,
-0.028155973,
0.03447827,
0.007934866,
0.016676016,
0.0051992564,
-0.009137893,
-0.029947717,
0.0046073413,
-0.022665558,
-0.017187942,
-0.0064790733,
0.016906383,
-0.039955888,
-0.005509612,
0.04461442,
-0.031483497,
0.023881385,
0.0135404635,
-0.0026380226,
-0.0031931433,
-0.03867607,
-0.023318265,
0.011998285,
0.003236337,
0.009560233,
-0.029819736,
-0.0042649903,
-0.01790464,
0.0017501498,
-0.017802253,
0.030229278,
0.020246705,
-0.023126293,
-0.028770287,
-0.03524616,
-0.023087898,
0.0068854154,
0.026594598,
0.04420488,
0.0031131548,
0.017034365,
-0.020937806,
0.032353774,
0.024393313,
0.004370575,
-0.0314579,
-0.012913354,
-0.01993955,
-0.011921495,
0.0035898867,
0.00083908,
-0.0051928572,
-0.022320008,
0.015959319,
-0.0035994854,
-0.0021868872,
-0.010212939,
-0.02188487,
-0.023049504,
0.00923388,
0.014692299,
-0.0020397084,
-0.015639363,
-0.007371746,
-0.03307047,
0.013194913,
0.0076917,
0.0015341806,
-0.006139922,
0.021616109,
-0.03475983,
-0.020592256,
-0.022780742,
0.0016005711,
-0.0023868587,
-0.032123405,
0.022153633,
0.00074349367,
-0.0036250816,
0.0075061265,
-0.002034909,
-0.003538694,
-0.01923565,
-0.0074293376,
-0.0073333513,
0.0024044563,
0.00055952,
-0.0314579,
-0.027362486,
-0.0013822024,
0.02063065,
0.02894946,
0.017213538,
0.04141488,
-0.007685301,
0.03181625,
-0.010763261,
-0.0050520776,
-0.036525976,
-0.009944178,
0.011870302,
-0.023267074,
0.024930835,
-0.014154776,
0.020118723,
0.028130377,
0.023945376,
-0.008619567,
0.01139677,
0.002909984,
0.0037466642,
-0.003698671,
0.0019549204,
0.0015605768,
0.01923565,
0.011204798,
0.008331609,
-0.0004643336,
-0.016048905,
-0.010436907,
-0.0031387513,
-0.00860037,
-0.01238223,
-0.012395027,
0.011275188,
-0.02404776,
0.00035394938,
-0.018071016,
0.01238223,
-0.010827252,
-0.028079184,
0.020733036,
0.022268815,
0.011716724,
-0.024111751,
-0.031355515,
-0.017034365,
0.011985486,
0.009841792,
-0.0036250816,
0.00048273097,
0.0018125408,
0.006866218,
-0.0075829155,
0.017367117,
0.034299094,
0.01630487,
-0.007774888,
0.010238536,
-0.030920379,
0.015856933,
-0.004200999,
0.028488725,
-0.0010390515,
-0.023177486,
-0.00063030986,
0.013258904,
0.0033179256,
0.0025868302,
-0.022166431,
-0.017507896,
0.0013510068,
0.010846449,
0.009137893,
0.0181734,
0.009867389,
0.035348546,
0.013527665,
0.02175689,
0.0005959148,
-0.021705696,
0.005224853,
0.017136749,
-0.008888329,
-0.0025644333,
0.008401998,
-0.03266093,
0.00964982,
-0.012062275,
-0.019593999,
0.041389283,
0.014295556,
0.02041308,
0.0023932578,
0.021436935,
0.005285644,
-0.00019047277,
-0.0074933283,
0.027157716,
0.0071797734,
0.0064598764,
-0.013617253,
-0.0110832155,
-0.0039386367,
-0.015575373,
0.024713267,
-0.0017581485,
0.015293813,
-0.0028283955,
-0.010232137,
-0.008773145,
0.0018637335,
0.004344979,
-0.013886014,
0.038087353,
-0.007851677,
0.0045017563,
0.014973858,
-0.009585829,
-0.012919753,
0.039392766,
0.02790001,
0.01859574,
0.0018013424,
0.011774316,
-0.01356606,
0.028027993,
0.0022268815,
0.0013670045,
-0.024329321,
-0.0060823304,
0.015268217,
-0.011128008,
0.0039962283,
0.00797326,
-0.0059191533,
-0.0040666186,
-0.044153687,
-0.004517754,
-0.01588253,
0.037677813,
-0.00032275385,
-0.003951435,
0.023139091,
-0.025481157,
-0.0015405797,
-0.0071349796,
-0.01552418,
0.031585883,
-0.011671931,
0.008261219,
-0.008689958,
-0.0011534351,
-0.00587436,
0.00314675,
0.013578858,
0.0075573195,
-0.009796999,
-0.01881331,
-0.0006567061,
0.0067446353,
0.0021356945,
0.025301982,
0.03138111,
0.0335568,
0.0028363944,
-0.0005503213,
0.013246106,
0.024994826,
-0.013169317,
0.008990714,
0.03539974,
-0.0030811594,
0.011633537,
-0.016420051,
-0.0110832155,
-0.02196166,
0.006693443,
0.02202565,
-0.009777802,
0.0031579484,
0.019043677,
0.0013206111,
0.003685873,
-0.019069273,
-0.032200195,
0.0039834306,
-0.012177459,
-0.0033019278,
-0.008805141,
0.009924981,
-0.009976174,
-0.012497413,
-0.04202919,
0.009886586,
0.009003513,
0.0026876156,
0.004223396,
-0.007768489,
-0.0052568484,
-0.021449734,
0.0074293376,
0.03944396,
-0.02133455,
-0.003887444,
-0.0073397504,
-0.0016925579,
0.0058231675,
-0.018506154,
0.0022476786,
0.00580397,
-0.010040164,
-0.0321746,
0.00020597054,
0.04028864,
0.0111344075,
0.02230721,
-0.027106524,
-0.0033787168,
0.016637621,
-0.036474783,
-0.020643448,
-0.023881385,
-0.01853175,
-0.004664933,
0.009400256,
-0.012497413,
-0.011844706,
0.0045625474,
-0.036116436,
0.020643448,
-0.023254275,
0.02244799,
-0.015421795,
0.019901155,
0.0064982707,
0.031150745,
0.028847074,
-0.009745806,
-0.0014773888,
-0.029077442,
-0.029742947,
0.015767345,
-0.010436907,
-0.011550348,
-0.012695785,
0.024790054,
-0.005253649,
0.013438079,
-0.003887444,
0.020246705,
-0.00986099,
0.015204226,
0.010084958,
0.014692299,
0.015741749,
-0.0044377656,
0.03153469,
-0.0040154257,
-0.0007734894,
-0.012273445,
0.0028923864,
0.032737717,
-0.011787115,
-0.01238223,
0.0073461495,
0.0014301955,
-0.02370221,
-0.012746978,
0.030408451,
-0.0014357946,
0.010827252,
-0.008901127,
-0.045868643,
-0.03419671,
-0.004866504,
0.0017869445,
-0.011627138,
-0.008274017,
-0.012836564,
-0.029333405,
0.005890358,
0.0040762173,
0.003721068,
0.05769415,
-0.024649275,
-0.009483444,
-0.02391978,
-0.02805359,
-0.020041933,
0.00293718,
0.006827824,
-0.034222305,
0.008734751,
0.009246678,
-0.03406873,
-0.018608538,
-0.01531941,
-0.01076966,
0.01091044,
0.037293866,
0.0051576626,
0.006267904,
0.017392714,
-0.011300784,
0.020784227,
-0.017943034,
0.0076725027,
-0.02805359,
0.03545093,
0.015434593,
-0.00867076,
0.010961632,
-0.033531204,
-0.015972115,
0.010456105,
-0.0028155975,
-0.006565461,
-0.015076244,
-0.024239734,
0.010481701,
0.033735976,
-0.020093126,
0.007237365,
-0.03609084,
-0.014577116,
0.03337763,
-0.0073845442,
0.010577687,
-0.030613223,
-0.006936608,
0.001133438,
0.019913953,
0.01796863,
0.010961632,
-0.0031515493,
-0.006629452,
0.010360119,
0.006517468,
-0.0037466642,
-0.0048697037,
0.0009974574,
-0.0070517915,
0.022831935,
-0.023561431,
0.010577687,
-0.024111751,
0.00086947565,
0.008427595,
-0.014103583,
-0.012523009,
0.008472389,
-0.022767944,
-0.018083815,
-0.013169317,
0.031022763,
-0.011595142,
0.010667275,
-0.044256072,
-0.014436335,
0.0030395654,
-0.016253676,
0.008427595,
-0.008773145,
0.011697527,
-0.0019901155,
-0.0018733321,
-0.005851963,
-0.007608512,
0.0012198256,
-0.0045625474,
0.014653904,
-0.02083542,
-0.008062847,
-0.017891841,
0.005343236,
0.022409596,
-0.0118895,
-0.015229822,
0.027362486,
-0.023779,
0.006405484,
-0.021590512,
-0.010404912,
0.0009950578,
0.00496569,
-0.0012358233,
-0.010801655,
-0.0020493069,
0.0018733321,
0.0071349796,
0.01685519,
-0.01006576,
0.013284501,
0.0034171115,
0.0004119411,
-0.011684729,
0.015281015,
-0.03586047,
-0.003973832,
0.0016005711,
0.017687071,
-0.010584086,
0.007960462,
0.016752804,
0.024841247,
0.012817367,
-0.00391624,
-0.000363748,
0.032763314,
0.0064854724,
-0.012849363,
0.032149002,
0.0043865726,
0.015204226,
-0.026824964,
-0.0044793594,
-0.035834875,
-0.0024348518,
0.009137893,
0.027362486,
0.010360119,
-0.013924409,
0.0017725466,
-0.035220563,
-0.01649684,
-0.021283356,
-0.0056183967,
0.00929787,
-0.02041308,
-0.014807482,
0.0046905293,
0.0043417793,
0.004904899,
0.00009078702,
-0.012849363,
0.00053272385,
0.032481756,
-0.021296155,
0.015869731,
-0.019120466,
0.017610282,
-0.003929038,
0.0041914005,
-0.030382855,
0.0021324952,
0.024636477,
-0.0034235104,
-0.031227535,
-0.008593971,
0.012407825,
-0.00026096267,
-0.004482559,
-0.0030299667,
0.019005282,
-0.0001712755,
0.0096946135,
-0.005909555,
-0.008651563,
0.030152488,
-0.02615946,
-0.0023388655,
0.019184457,
-0.020579457,
-0.015268217,
0.002607627,
-0.0048505063,
-0.0002825596,
0.013361289,
-0.03662836,
-0.044512033,
-0.01769987,
-0.0151402345,
-0.014359547,
-0.0068982136,
-0.0028091983,
-0.021001797,
0.0066102548,
0.0071989708,
0.0092146825,
-0.012241449,
0.025762716,
-0.0075445212,
-0.00033035275,
-0.025161201,
0.008901127,
0.005420025,
-0.027746432,
-0.020937806,
0.00065070693,
0.011230394,
0.008069246,
0.02902625,
-0.010430508,
-0.016765602,
0.016970374,
-0.06245507,
-0.020118723,
-0.00011448363,
0.012350234,
0.008152435,
0.012395027,
0.0021868872,
-0.017303126,
-0.007947664,
0.0031563486,
-0.020336293,
-0.023830192,
0.034350287,
0.005922353,
0.010936036,
-0.0002811598,
-0.029435791,
-0.018915694,
0.015485786,
-0.012535808,
0.004277788,
0.017264731,
0.0055704033,
0.0014557919,
-0.013092528,
0.02600588,
0.0050008846,
0.013655648,
0.018211795,
-0.04952892,
0.0017453504,
0.008350805,
-0.0029355802,
-0.008792343,
0.019197255,
-0.008766746,
0.02404776,
-0.010257733,
-0.015281015,
-0.019197255,
0.018928492,
-0.0071157822,
0.0018445363,
0.01635606,
-0.018275786,
0.035886068,
0.0021548918,
-0.0064662755,
-0.014167574,
-0.0023228677,
-0.007006998,
0.014359547,
-0.0036826734,
0.018378172,
-0.029333405,
0.01762308,
0.008274017,
-0.033326436,
0.01873652,
0.0029243818,
-0.003125953,
0.0005475217,
-0.0024396512,
0.017111152,
0.005845564,
0.01069927,
0.011844706,
-0.011364775,
-0.0042329947,
-0.03153469,
0.003679474,
-0.0004991286,
-0.015101841,
0.010129752,
0.0011654333,
-0.017994227,
-0.01098083,
-0.01915886,
-0.0056183967,
0.015447391,
0.17661475,
0.0007734894,
-0.010257733,
0.029461388,
-0.0068150256,
0.00923388,
0.010366518,
-0.006699842,
-0.013732436,
-0.012555005,
0.004930495,
0.0071093836,
-0.01630487,
-0.0070133973,
0.015652161,
-0.027285699,
-0.010097756,
0.003028367,
0.011108811,
0.0043129832,
-0.0002733609,
-0.0068982136,
-0.005420025,
-0.002468447,
0.032046616,
-0.006987801,
-0.0031515493,
0.009432252,
0.034580655,
-0.0067254384,
-0.0006411083,
0.010667275,
-0.011633537,
0.0076277093,
0.023484642,
0.01055849,
0.0056887865,
-0.008753948,
0.013335693,
-0.006776631,
0.011985486,
-0.0068918145,
-0.038906436,
-0.006091929,
-0.00964982,
0.029691754,
-0.007083787,
-0.00072869577,
-0.024098953,
-0.009566632,
-0.054980937,
-0.015421795,
0.0084659895,
0.027746432,
0.005551206,
-0.0015677758,
0.012887757,
0.0054104263,
0.010078559,
0.0012646192,
-0.017879043,
-0.0015957718,
-0.0042905863,
0.006699842,
-0.02769524,
-0.0018061417,
-0.026773771,
-0.018877301,
-0.0040666186,
-0.010795256,
0.009707412,
-0.014858675,
0.013438079,
-0.0029051846,
-0.010308926,
0.00029535775,
0.0167784,
0.013322894,
-0.015498584,
0.011032023,
0.005160862,
-0.019389227,
-0.015562574,
0.015984913,
-0.012107069,
-0.03194423,
-0.004140208,
0.005448821,
-0.014346749,
-0.014103583,
-0.006578259,
-0.035297353,
-0.023510238,
-0.015767345,
-0.0043257815,
-0.011838307,
-0.008485187,
-0.005260048,
-0.03189304,
0.006789429,
-0.02874469,
0.08380242,
-0.005404027,
0.015178629,
0.0030875586,
0.013719638,
-0.009278673,
0.027388083,
-0.009144292,
0.0039034418,
0.006834223,
-0.0064374795,
0.005490415,
-0.005432823,
-0.016215282,
0.0072629615,
0.015025051,
-0.018570144,
0.019504411,
-0.030945975,
-0.0010518496,
0.009425852,
0.007883673,
0.025135607,
-0.0059159542,
0.019926751,
-0.02894946,
0.028155973,
-0.004428167,
-0.03711469,
0.0028715893,
-0.004904899,
-0.008529981,
-0.00024276528,
0.03132992,
0.017085556,
-0.0039386367,
-0.013361289,
0.022537578,
0.009592229,
0.0017117552,
-0.008523582,
0.013335693,
0.009265875,
0.019901155,
-0.0037466642,
0.015460189,
-0.004063419,
-0.017072758,
0.00412421,
-0.008715554,
-0.016906383,
0.02048987,
0.00000811134,
0.02399657,
-0.022550376,
-0.012753376,
-0.03266093,
-0.01244622,
0.007838879,
-0.004648935,
0.008101242,
0.02118097,
-0.035143774,
-0.015562574,
-0.0012430223,
-0.15839015,
0.022460788,
0.031099552,
-0.004623339,
0.03795937,
-0.005109669,
0.0100145675,
0.015716152,
-0.0062711034,
0.017943034,
0.02217923,
-0.0060375365,
-0.016445648,
-0.01650964,
-0.0024668472,
0.025020422,
0.008504384,
-0.0041722036,
0.021731293,
0.01846776,
0.019453218,
0.008216425,
0.02636423,
-0.03322405,
-0.0018957289,
0.004876103,
-0.0003923439,
0.0051224674,
0.005048878,
-0.0015053847,
-0.014461932,
0.015831336,
0.016970374,
-0.0060055414,
0.01461551,
0.006693443,
0.015217024,
-0.033735976,
-0.01084005,
0.009329866,
0.009189086,
0.007659705,
-0.020643448,
-0.010392114,
-0.021859273,
0.007538122,
-0.0016285671,
0.003308327,
0.0074101402,
-0.010756861,
0.025839506,
-0.0015277815,
-0.010507298,
0.03266093,
0.013514867,
0.0065270667,
-0.018237391,
0.0039322376,
0.002362862,
0.016061703,
-0.009617825,
-0.007538122,
0.023612624,
0.03271212,
-0.0035290953,
0.00034775026,
0.015959319,
-0.007742893,
-0.027285699,
0.019542806,
-0.042925064,
-0.020899411,
0.008050049,
-0.006987801,
0.015690556,
0.01496106,
0.008958719,
-0.01475629,
-0.0015997712,
0.028437534,
0.007314154,
0.023395054,
-0.01139677,
-0.028309552,
-0.021308953,
0.014781886,
0.0052216533,
0.010449706,
-0.0071989708,
-0.017405512,
0.005691986,
-0.032404967,
-0.0075701172,
-0.015741749,
0.00056271954,
0.0074101402,
0.027592855,
-0.0053176396,
-0.002943579,
-0.023779,
0.04159405,
-0.0073845442,
0.004005827,
0.026261844,
0.01734152,
0.007845278,
0.008210026,
0.012548606,
0.036449187,
-0.002812398,
-0.011550348,
0.00073749456,
0.0053944285,
0.045612678,
0.0006063133,
0.023203082,
0.026057074,
-0.025788313,
0.0053880294,
-0.022076843,
0.048812218,
0.01223505,
0.010078559,
0.008318811,
0.025788313,
-0.037370656,
-0.12470537,
-0.047174055,
-0.006699842,
0.011863903,
0.018416567,
0.017789457,
0.007390943,
0.040007077,
0.005298442,
0.029435791,
0.003580288,
0.022332806,
0.0020573058,
0.0027164116,
0.0061783167,
0.00034295095,
-0.014602711,
-0.006411883,
-0.023535835,
0.02979414,
-0.013553262,
-0.013156518,
0.0010502498,
-0.009483444,
-0.0015077844,
0.011102412,
-0.017943034,
0.01839097,
0.0032155402,
-0.004789715,
0.02006753,
-0.0017661474,
0.008913925,
-0.02055386,
-0.007442136,
-0.0037882582,
0.027951203,
-0.022000054,
0.032891296,
-0.015844135,
0.0067382366,
-0.0026668187,
0.031278726,
-0.010155348,
0.018762117,
-0.024111751,
-0.025609137,
0.017021567,
-0.019146062,
-0.018710924,
-0.030280469,
-0.0035898867,
-0.027311295,
-0.006018339,
0.022064045,
0.010673674,
0.021475328,
0.024982028,
-0.0342479,
0.0056535914,
0.009643421,
-0.007320553,
-0.0059831445,
0.006181516,
0.014743492,
-0.021769688,
-0.013086129,
-0.027592855,
0.016112896,
-0.037805792,
-0.0121518625,
0.004594543,
-0.0016829594,
-0.006616654,
-0.015025051,
0.010251334,
-0.005013683,
-0.022396797,
0.000042893866,
0.0071157822,
-0.028360745,
-0.016266475,
0.012164661,
-0.0057175825,
-0.0003755463,
0.012695785,
0.012580601,
0.011147206,
0.001922925,
-0.002754806,
-0.020400282,
0.016164089,
0.0044505633,
-0.008677159,
0.0072053694,
-0.0043929718,
0.006866218,
-0.002153292,
0.019120466,
-0.020605054,
0.011460762,
-0.047865156,
-0.037729006,
0.007531723,
0.0034107124,
0.0011414367,
0.00650467,
-0.014692299,
0.03048524,
0.017955832,
0.013873216,
-0.016637621,
-0.037498638,
-0.00075989135,
-0.00936826,
-0.00881154,
-0.035297353,
-0.012842963,
0.021193769,
-0.005986344,
0.0112943845,
0.013578858,
0.0054360228,
0.02713212,
-0.015498584,
0.018992484,
0.018800512,
-0.0017037564,
-0.009745806,
-0.008318811,
-0.03237937,
-0.013758033,
0.0006263104,
-0.041363686,
-0.00019817166,
0.007371746,
-0.023791797,
0.01132638,
-0.0321746,
0.028795883,
-0.0010518496,
0.010404912,
-0.02818157,
-0.021283356,
-0.00027496068,
-0.013105326,
0.01524262,
-0.008606769,
-0.023177486,
0.0011222395,
-0.02692735,
-0.0174823,
0.03278891,
0.010827252,
-0.012682986,
-0.01929964,
-0.0145003265,
0.00009533636,
-0.001713355,
-0.0043193824,
0.005320839,
-0.019261247,
0.025084414,
-0.004428167,
-0.0018077415,
-0.0031291526,
0.015076244,
0.009099498,
-0.009496242,
0.011499155,
0.027490469,
0.015293813,
-0.021475328,
-0.018518953,
-0.010942435,
-0.0050168824,
0.016522437,
0.006629452,
-0.0062327087,
0.0077044982,
-0.009758605,
0.003967433,
0.0055704033,
0.0049560913,
-0.022614365,
0.04599662,
0.02951258,
0.0002713612,
0.0028267957,
0.01782785,
0.003397914,
0.005208855,
-0.009560233,
0.0024012567,
-0.0073461495,
0.013604455,
0.018378172,
0.031304322,
-0.0012190257,
0.00026316236,
0.0058487635,
0.043820933,
0.020400282,
0.023011109,
-0.016023308,
-0.017712668,
-0.0016701611,
0.019798769,
-0.032635335,
-0.02426533,
-0.03181625,
-0.003308327,
0.0011966289,
-0.0012366232,
0.016829593,
0.007960462,
-0.002327667,
0.016599227,
-0.015920924,
0.0028059988,
-0.0037562628,
0.024316523,
0.008779544,
0.0015869731,
0.002418854,
0.008024452,
0.019542806,
0.00034035134,
0.017264731,
-0.021142576,
-0.00092306803,
-0.011198399,
0.012804569,
0.0027516065,
-0.035604507,
-0.004421768,
0.0035706894,
-0.039315976,
0.035783682,
0.02887267,
-0.0042553917,
0.07663544,
-0.006280702,
0.0074165394,
0.005160862,
0.010398513,
0.027157716,
-0.011742321,
0.010475302,
-0.021321751,
-0.0356557,
-0.014141978,
-0.008274017,
0.04320662,
-0.033761572,
-0.026415423,
0.021129778,
0.0036698752,
0.011966289,
0.019606797,
-0.0016325666,
0.012734179,
-0.017776659,
0.0009190686,
0.01657363,
-0.020041933,
0.0070581906,
0.0580525,
-0.017507896,
-0.011025623,
-0.033505607,
-0.015217024,
0.019043677,
-0.029947717,
-0.010033765,
0.0017789456,
-0.02111698,
0.0021852874,
-0.012087871,
-0.0038938432,
0.004428167,
-0.0067190393,
0.017098354,
-0.025724322,
-0.016586429,
-0.016036106,
-0.019107668,
-0.044512033,
0.025340376,
-0.030024506
] |
Protoplasmic astrocytes in mammalian CNS tissues in vivo have a highly complex 3D morphology, but in dissociated cell cultures they often assume a flattened, fibroblast-like morphology bearing only a few, simple processes. By fluorescent labeling and confocal reconstruction we show that many astrocytes in organotypic hippocampal slice cultures exhibit a more native complex cytoarchitecture. Although astrocytes at the surface of slice cultures show a reactive form with several thick glial fibrillary acidic protein (GFAP)-positive processes, astrocytes situated in deeper portions of tissue slices retain a highly complex 3D morphology | [
-0.020324046,
0.020154243,
0.00900606,
-0.028187204,
-0.0065569864,
0.006638622,
-0.0025682617,
0.035162166,
-0.0135972565,
-0.01801212,
0.025091575,
-0.0038009621,
0.0073341588,
-0.00018868071,
-0.01278743,
-0.003911987,
0.027664734,
-0.005139789,
-0.022910267,
0.02315844,
-0.024765031,
0.019030934,
-0.012349862,
-0.0070076156,
-0.0045160917,
0.023889896,
0.003245839,
-0.023145378,
-0.00029592973,
-0.027063895,
0.006638622,
-0.024595229,
-0.013832367,
-0.0047283447,
-0.000044899683,
-0.0242295,
0.015647948,
-0.0073406897,
0.0017698638,
0.026907155,
0.004267919,
-0.0073668133,
-0.016105108,
0.0057471595,
-0.00078941806,
0.0026564284,
-0.021826144,
-0.0032082864,
-0.010769392,
0.019435847,
0.031818364,
0.017829256,
0.013087849,
-0.0060116593,
-0.013231528,
-0.027952094,
-0.0056132767,
0.0006057375,
-0.004254857,
-0.034091104,
-0.003578913,
-0.010965318,
-0.02375928,
0.037748385,
-0.00984201,
0.03239308,
0.006759443,
0.02050691,
0.02195676,
-0.01831254,
0.022113502,
0.012591504,
-0.016483897,
-0.013466639,
0.017319849,
-0.008490122,
-0.019187676,
-0.008228887,
-0.012193121,
0.013897676,
-0.00681169,
-0.042215496,
-0.018599898,
0.025300562,
-0.0059985975,
0.023863772,
-0.015478145,
0.001343725,
0.0025600982,
0.0012759673,
0.0038695363,
0.035658512,
0.0065504555,
0.025535673,
0.004245061,
-0.0019739533,
-0.017241478,
0.041039944,
-0.005916962,
-0.018482342,
-0.013675626,
0.011722899,
-0.013832367,
-0.024190316,
-0.0030678727,
-0.0040883203,
0.03142651,
0.026515303,
0.014877305,
-0.016483897,
0.013767059,
0.023824587,
-0.0006804343,
-0.030224834,
0.011984133,
0.028892538,
0.04093545,
-0.017920688,
-0.003853209,
-0.009437096,
-0.007915406,
0.01143554,
0.0392113,
-0.011455134,
0.03027708,
0.038114116,
0.019096242,
0.005570826,
-0.013793183,
0.004290777,
0.020519972,
0.011487788,
0.0002005179,
0.0027168388,
-0.00802643,
-0.015804688,
-0.010893479,
0.0058875727,
0.004956925,
-0.036050364,
0.008973406,
0.01733291,
-0.02059834,
0.009430566,
-0.016327158,
0.020258736,
0.028709672,
0.01854765,
0.017345972,
0.0044475175,
0.022022069,
-0.011474726,
0.009038714,
-0.00847706,
-0.0044475175,
0.014041355,
-0.008209295,
0.02468666,
-0.039916635,
-0.01256538,
0.0075823315,
-0.0038009621,
0.008914628,
0.009894257,
0.0043397583,
0.019017873,
-0.0062337085,
0.0083529735,
0.013100911,
-0.015987553,
0.0020310984,
0.010449381,
-0.02277965,
0.0111938985,
-0.0068704677,
0.0023217218,
0.016105108,
0.00961343,
-0.022818835,
-0.019305231,
-0.0010024875,
0.00726885,
0.005822264,
-0.005283468,
0.012741714,
0.012728652,
0.04456661,
-0.017685577,
0.018665206,
-0.014041355,
0.0021682465,
0.0068835295,
-0.033960488,
-0.024360118,
-0.64869756,
-0.035475645,
0.015804688,
-0.04049135,
0.0068965913,
0.05209016,
-0.012127812,
-0.01513854,
-0.0046303817,
0.008052554,
-0.025836093,
0.038323104,
-0.01438096,
-0.011585751,
-0.021329798,
-0.01551733,
0.009058307,
-0.002733166,
0.01105022,
-0.007510492,
-0.024307871,
-0.009848542,
-0.0052802027,
0.004117709,
0.015909182,
0.047126707,
0.029780734,
-0.041457918,
-0.02164328,
0.05274325,
-0.046525866,
0.017515775,
-0.01718923,
0.0012686201,
0.047858164,
-0.012258429,
-0.020297922,
0.032340832,
0.010684491,
0.02308007,
-0.0012482111,
-0.0043495544,
0.008797072,
0.013309899,
-0.026619798,
0.014720565,
0.0022907,
-0.01944891,
0.003921783,
-0.0056132767,
0.0016637373,
0.00359524,
-0.024947897,
0.012212713,
0.015034046,
-0.0009853439,
0.013832367,
0.004604258,
0.028631303,
0.0044018016,
0.0036246288,
-0.0030744036,
-0.01641859,
-0.028552933,
-0.005841857,
0.007425591,
-0.0055544986,
-0.008130924,
0.014459331,
0.011749023,
0.006037783,
0.012624158,
-0.014446269,
-0.0135972565,
-0.017881501,
0.027978217,
0.003146243,
-0.0026107123,
-0.005058153,
0.014145849,
-0.00855543,
-0.0007420693,
-0.027429624,
0.0069880234,
0.005472863,
0.009358726,
-0.010638775,
0.024569105,
0.0017731292,
0.0007588046,
0.0011420846,
-0.0014025028,
0.0033470672,
-0.05465026,
-0.015700195,
0.025914464,
-0.016131232,
0.013793183,
0.017594144,
-0.0337515,
-0.010390603,
-0.0106257135,
0.010377541,
0.017359033,
-0.0012180059,
0.022126563,
-0.03625935,
0.00015316914,
0.043129817,
-0.036363844,
-0.019331355,
-0.0056263385,
-0.0017225151,
-0.020951008,
0.01234333,
-0.016353281,
0.020206489,
0.010037936,
-0.0034482956,
-0.016823502,
0.005818999,
-0.001544549,
0.011997195,
0.01317275,
0.023589477,
-0.009535059,
0.01324459,
-0.014198096,
-0.024595229,
0.008797072,
-0.014655256,
0.0028850087,
0.018678268,
-0.020454662,
0.011866578,
0.016405527,
0.014720565,
0.0041895485,
0.011415948,
-0.03239308,
-0.01573938,
0.0031903265,
-0.00027286762,
-0.029650116,
-0.004858962,
-0.0064328997,
-0.03035545,
0.0036148326,
-0.0020392619,
-0.0014865877,
-0.017829256,
-0.0067463815,
-0.0013796447,
0.0005208363,
0.028814167,
-0.010802047,
-0.007151295,
-0.026476119,
0.018286416,
-0.003405845,
-0.012075566,
0.010540812,
0.01415891,
0.022792712,
-0.0142634045,
-0.016340218,
-0.00022429432,
-0.002073549,
-0.0008832992,
-0.028474562,
-0.009626492,
-0.0015984287,
-0.000047552843,
0.017999059,
-0.012389047,
0.0063022827,
0.0059528816,
0.006387184,
0.0008110515,
-0.013238059,
0.0055512334,
0.0009796295,
0.0050222334,
-0.0018694595,
0.03346414,
0.011853516,
0.027638612,
0.014942614,
-0.010233862,
0.023145378,
0.012761306,
0.056008678,
-0.009326072,
0.008143986,
-0.02831782,
-0.023289056,
0.0010318763,
-0.006034517,
0.007752134,
0.02066365,
0.03239308,
-0.010037936,
-0.0011918824,
-0.0049765175,
0.039995003,
-0.014106664,
0.0055447025,
-0.022361673,
-0.022949452,
0.011220022,
0.0017127187,
0.0019004811,
0.0025633636,
-0.019853823,
-0.010201207,
0.0014580152,
0.012062504,
-0.0037258572,
0.003882598,
-0.012604565,
0.012643751,
-0.0006559435,
0.010135899,
0.002584589,
-0.0064426963,
0.021081625,
-0.0075366157,
0.036781818,
-0.0009428933,
-0.033411894,
0.008150517,
0.025744662,
0.019017873,
0.03913293,
0.026214883,
0.0113571705,
-0.0011412683,
-0.01430259,
0.03730429,
0.010168553,
0.017032491,
0.007954591,
0.00015480186,
0.016144292,
-0.0001257191,
-0.0060116593,
0.027507994,
0.017202294,
0.0035625857,
-0.009450158,
-0.0009747313,
-0.0019347682,
-0.010573467,
0.0026776537,
0.0058614495,
0.02036323,
0.0062271776,
0.01256538,
0.015700195,
0.02429481,
0.008235418,
-0.0044997646,
-0.010945726,
-0.0129964175,
-0.0089864675,
0.002331518,
0.020337107,
-0.025914464,
-0.0123955775,
-0.005587153,
-0.028187204,
-0.013871552,
0.0019804842,
-0.031896733,
0.0026613267,
-0.0023233544,
0.0012653547,
0.015647948,
0.019030934,
-0.002349478,
-0.030224834,
-0.021238366,
0.006586375,
0.023563353,
0.0030629747,
-0.019814638,
-0.024778094,
-0.0049765175,
-0.012663343,
-0.008738294,
0.010442849,
-0.0071643563,
-0.0036050363,
0.0061063566,
-0.028866414,
-0.024464613,
0.011788207,
-0.0018759903,
0.018821947,
-0.018560711,
-0.0073341588,
-0.008013369,
-0.012741714,
0.0021029378,
0.041797522,
0.011180837,
-0.011043689,
0.011455134,
-0.009600368,
-0.018351724,
-0.008176641,
-0.01037101,
0.010802047,
0.017515775,
-0.011814331,
-0.01717617,
-0.003951172,
-0.0059692087,
0.04482784,
0.011233084,
-0.009698331,
-0.02066365,
-0.012695997,
-0.022440044,
0.017607206,
0.018181922,
-0.010397133,
0.007621517,
0.021212243,
-0.011566158,
-0.007856628,
-0.013068257,
0.015935306,
-0.019266045,
-0.006599437,
-0.019697083,
0.011304923,
-0.0016670027,
0.03299392,
0.027037771,
-0.010214269,
-0.007660702,
-0.0013788284,
0.0063414676,
0.025065452,
-0.0187697,
0.012225775,
0.038636584,
0.026371624,
-0.008006838,
0.008268072,
0.01097838,
0.008895035,
-0.029832982,
0.012624158,
0.022387797,
0.0198277,
-0.010730208,
-0.030172586,
-0.030172586,
0.007530085,
-0.005289999,
0.02028486,
0.021786958,
0.0025078512,
0.018586835,
0.015073231,
-0.018795824,
-0.009730985,
-0.014550762,
0.002520913,
-0.0073145665,
-0.0147989355,
-0.028448438,
0.017372096,
-0.019122366,
0.023380488,
-0.014903429,
-0.0022106972,
-0.031139154,
-0.0010620815,
-0.023145378,
0.016692886,
-0.017345972,
-0.012519664,
-0.0016947589,
-0.0048393696,
-0.0135319475,
-0.00016072045,
-0.022544539,
0.00946322,
0.0006269628,
-0.033934362,
-0.0075431466,
0.023367427,
-0.028526809,
-0.04360004,
0.012552318,
0.014394022,
0.031531006,
0.012571911,
-0.014616071,
0.0062239124,
0.022740465,
-0.00055104156,
-0.01142901,
-0.019592589,
-0.026423872,
-0.01007059,
-0.0010073856,
-0.008757887,
-0.016170416,
0.009208516,
-0.012389047,
0.019161552,
-0.026881032,
-0.015282219,
0.018874193,
0.0012139241,
0.0135319475,
0.042737965,
0.0036899375,
0.0076868255,
-0.0080199,
0.0011600445,
-0.020154243,
-0.008359505,
-0.008712171,
-0.008581554,
-0.0032654314,
-0.014707503,
-0.011317985,
-0.0142634045,
-0.009064837,
0.0014392389,
-0.019135429,
0.019161552,
-0.0011412683,
0.0106910225,
0.001263722,
-0.0066614803,
0.0019608915,
0.01309438,
-0.019083181,
0.0015053638,
-0.009580776,
0.031008536,
0.008268072,
-0.027090019,
0.01854765,
0.014642195,
-0.027664734,
-0.017894564,
-0.020324046,
-0.004117709,
0.02262291,
0.0061259493,
-0.015190787,
0.004705487,
-0.00066737254,
-0.021368982,
-0.0013788284,
0.009561183,
0.0034025796,
-0.011063281,
0.020689774,
0.0030695056,
0.0075823315,
-0.010181615,
-0.045611545,
-0.0111612445,
0.025457304,
0.025326686,
0.008718702,
-0.016065922,
-0.01597449,
-0.005058153,
-0.012153936,
-0.013793183,
-0.024320934,
0.006857406,
-0.00079676526,
0.022204934,
0.03150488,
0.018064367,
0.024817279,
0.025143823,
0.016157355,
-0.011396356,
-0.003549524,
0.014459331,
0.0053487765,
-0.023654785,
0.026018957,
-0.0063088136,
-0.019187676,
0.01643165,
-0.018351724,
0.014629133,
0.024464613,
-0.013153158,
-0.017920688,
0.007484369,
-0.009861602,
-0.021382045,
0.017607206,
-0.009783233,
-0.0059626778,
-0.022087378,
0.0059300233,
0.026881032,
0.011951479,
-0.0073994678,
-0.022087378,
0.045898903,
-0.0026547958,
-0.0016816972,
0.0016588392,
0.003830351,
0.0010506526,
-0.021447353,
-0.0021568174,
-0.02028486,
0.015804688,
0.009783233,
0.00541082,
0.0018417033,
0.0011257575,
-0.0037781042,
0.01960565,
-0.0039642337,
-0.005192036,
-0.005482659,
-0.012140874,
-0.027612489,
-0.02323681,
-0.023406612,
-0.035554018,
-0.009730985,
0.009515467,
-0.021094687,
0.027690858,
-0.006955369,
-0.014811997,
0.045663793,
-0.010860825,
0.03662508,
-0.015856935,
-0.00016521043,
0.0076802946,
-0.009744047,
-0.021551847,
-0.008261542,
0.01218659,
-0.007099048,
0.014171972,
0.008359505,
-0.02066365,
-0.024634415,
0.002181308,
0.037722263,
0.00786969,
-0.032680437,
0.01695412,
0.03275881,
-0.0023168237,
-0.010331825,
-0.0022727402,
-0.029127648,
0.021081625,
-0.008085208,
-0.0129637625,
0.0019951786,
-0.007288443,
-0.017907625,
0.038035747,
0.012650281,
0.023824587,
0.0059985975,
0.017541898,
0.0019608915,
-0.0023576415,
0.0011175938,
0.0062304433,
0.0062565664,
0.034796435,
-0.004705487,
0.011265738,
-0.0042124065,
0.019357478,
-0.014145849,
-0.009254233,
-0.00092085166,
0.032366958,
0.01695412,
-0.005979005,
0.019488094,
0.036886312,
0.023824587,
-0.00012337208,
-0.010984912,
-0.0039250487,
-0.00435282,
-0.0047283447,
0.037513275,
-0.009920381,
0.016758194,
-0.009267295,
-0.0114224795,
0.0043854746,
-0.017136984,
-0.01370175,
-0.011252677,
-0.04148404,
-0.015713256,
0.020872638,
0.021303674,
-0.0046467087,
-0.012088627,
0.0017584348,
-0.008744826,
0.018194985,
-0.026593674,
0.01990607,
0.03354251,
0.019553402,
-0.031583253,
0.00219437,
-0.013048664,
-0.031557128,
-0.001200046,
-0.019200737,
-0.038714956,
-0.02748187,
-0.0006281874,
0.02513076,
-0.002527444,
-0.024307871,
-0.005721036,
0.004718548,
0.005358573,
0.005071215,
-0.008392159,
0.0010384072,
-0.0023445797,
-0.009319541,
-0.017319849,
-0.03686019,
-0.00794806,
0.0017078206,
-0.025313625,
0.0038564745,
-0.0012180059,
0.016327158,
-0.014576886,
-0.005466332,
-0.027899846,
0.0036278942,
0.0069945543,
-0.0050287643,
-0.017372096,
0.0025698945,
-0.0031560394,
-0.0129311085,
-0.014616071,
0.028918661,
-0.0044475175,
-0.007099048,
-0.017881501,
-0.008124393,
-0.009848542,
-0.044253126,
-0.033202905,
0.007144764,
-0.016927997,
0.037670016,
-0.0004204243,
-0.01763333,
-0.005387962,
-0.0070206774,
-0.058412038,
-0.01165106,
-0.0046271165,
0.0064753504,
-0.0070337392,
0.024242563,
-0.008895035,
-0.025875278,
-0.012571911,
0.029336635,
0.0020033421,
-0.008228887,
0.036363844,
-0.019435847,
0.014250343,
-0.018181922,
-0.032288585,
-0.024660539,
0.02437318,
-0.005691647,
-0.0009918748,
0.0045226226,
-0.009032183,
0.0337515,
-0.0075627393,
0.018808885,
-0.015190787,
0.019644836,
0.0027380642,
-0.021055501,
0.013871552,
0.0015469982,
-0.0037683079,
-0.0061128875,
-0.00794806,
-0.002320089,
-0.007810912,
0.0123368,
-0.002297231,
-0.016470836,
0.012199651,
-0.007863159,
0.011677182,
0.010455911,
-0.0033731908,
0.02967624,
0.02012812,
-0.0064394306,
-0.0015567944,
-0.014563824,
-0.022348613,
0.008457467,
0.010860825,
0.008699109,
0.018208046,
0.018678268,
0.0019004811,
-0.018364787,
0.0050450917,
-0.02058528,
0.007183949,
-0.025104636,
0.016105108,
0.0046826284,
0.00095024053,
-0.003285024,
0.00115433,
0.0011102466,
-0.003319311,
0.01786844,
0.0019119101,
0.012878861,
0.0018629286,
0.015425898,
0.004783857,
-0.023811527,
-0.013238059,
-0.013368676,
-0.015478145,
0.0022221261,
0.1704294,
-0.018730514,
0.007987245,
-0.0066516837,
-0.026881032,
0.0011812698,
0.010279578,
-0.0027772493,
0.0026515303,
0.0031968574,
0.0062794248,
0.0064361654,
-0.012291084,
-0.009299949,
0.017685577,
-0.0067920974,
-0.019030934,
-0.012676405,
-0.020846514,
-0.008085208,
0.003784635,
-0.014054417,
0.04117056,
0.022074316,
0.033359647,
-0.0062794248,
-0.011461664,
-0.012180059,
0.017920688,
0.031661622,
-0.0019559935,
-0.00021449802,
-0.0050810114,
0.005822264,
0.012767836,
0.0045324187,
-0.025901401,
0.007183949,
0.014498515,
-0.012774368,
-0.008992998,
-0.0014825058,
0.01596143,
0.0066353567,
-0.02383765,
0.02323681,
0.01317275,
-0.012839676,
-0.006289221,
0.0038401473,
-0.04093545,
0.011252677,
0.005116931,
0.023053946,
0.016457774,
-0.0055904184,
0.0140021695,
0.008875443,
-0.014250343,
0.03837535,
-0.037591647,
0.035397276,
-0.01785538,
0.028500685,
-0.0070076156,
0.0041438323,
0.010834701,
-0.008313788,
0.013002948,
-0.0028980703,
0.017698638,
-0.0064622886,
-0.020559156,
-0.017894564,
-0.005058153,
-0.013198874,
0.050888482,
0.014289528,
0.008679517,
0.0154650835,
-0.016666763,
0.011252677,
-0.013375207,
0.026907155,
0.006161869,
-0.039550904,
0.027716981,
0.019422786,
-0.0015298546,
-0.018652145,
0.0089864675,
-0.0057700174,
0.0073080356,
-0.0028915396,
0.017293725,
-0.02558792,
0.011846985,
0.00050124375,
-0.031609375,
-0.0021551847,
-0.022126563,
0.06546537,
0.022518415,
0.012134343,
-0.014224219,
-0.004927536,
-0.017737823,
0.013107441,
-0.0010228964,
-0.0070141465,
-0.0068835295,
-0.041771397,
-0.0060214554,
-0.015909182,
-0.0076019242,
0.01325112,
-0.014433207,
-0.04148404,
0.04858962,
0.011866578,
-0.018861132,
-0.016967181,
0.02375928,
-0.003342169,
-0.022270242,
-0.015347527,
-0.026985526,
0.008281134,
0.005828795,
-0.04033461,
-0.0014261772,
-0.0129637625,
-0.0031609377,
0.018221106,
-0.0014229118,
0.01922686,
0.0016531247,
0.011566158,
0.006295752,
0.0046826284,
-0.013753997,
-0.020337107,
0.0067333197,
0.0041830176,
-0.005035295,
0.012937639,
0.007902344,
0.022440044,
-0.016183479,
-0.006615764,
-0.009979159,
-0.018652145,
-0.0046205856,
0.0069814925,
0.013479701,
-0.037879005,
0.006632091,
-0.029493377,
-0.009574245,
-0.013884614,
-0.031739995,
0.0055479677,
0.017398218,
-0.008183171,
-0.021695526,
-0.014015231,
-0.16321932,
0.016510021,
-0.0004420578,
-0.025705475,
0.010677961,
0.009815887,
0.018116614,
-0.01785538,
-0.007895813,
0.027116142,
0.020624464,
-0.007856628,
-0.03638997,
-0.012173528,
0.013571133,
-0.004013215,
0.008059084,
0.027638612,
0.014589948,
0.013453578,
0.014524639,
-0.032445326,
0.0035919745,
-0.0012359658,
0.013858491,
0.01415891,
0.0048916163,
0.0012041278,
-0.008032961,
-0.012545788,
0.0054402086,
0.0058875727,
0.02216575,
-0.0031037927,
0.026528364,
-0.018861132,
-0.016941058,
-0.0071643563,
-0.0072557884,
0.019187676,
0.012251899,
0.012898454,
-0.008757887,
-0.010305702,
-0.019252984,
0.015608762,
0.0011069813,
-0.014864244,
0.026449995,
-0.007895813,
0.014028293,
-0.014929553,
-0.007059863,
0.046290755,
0.013087849,
0.021173058,
0.024556044,
0.019697083,
0.019239921,
-0.014485454,
-0.002623774,
-0.019945255,
0.03377762,
-0.0026172432,
-0.010939195,
-0.012872331,
-0.008529306,
-0.009580776,
-0.03414335,
0.0015323036,
0.0022776383,
-0.016026737,
0.026319377,
-0.01619654,
0.008686048,
0.020075873,
-0.02172165,
0.005178974,
0.0044246595,
0.00081390876,
-0.024765031,
0.00526061,
-0.024059698,
-0.030459944,
-0.016444713,
-0.010083652,
0.018939503,
0.009848542,
-0.022035131,
0.008836257,
0.029232142,
-0.02535281,
-0.01627491,
0.010318764,
0.026854908,
0.03443071,
-0.0035593202,
-0.0067659738,
-0.006184727,
0.00055838877,
0.033725377,
-0.00079513254,
-0.04161466,
0.01786844,
0.033594757,
0.021577971,
-0.022387797,
0.019697083,
0.026907155,
-0.005283468,
-0.022231057,
-0.0062500355,
0.018181922,
0.020075873,
-0.005371635,
0.0274035,
0.020924885,
-0.0028801104,
0.020911822,
-0.019396663,
0.053082854,
0.004156894,
-0.0107889855,
0.022348613,
-0.00051471364,
-0.013558071,
-0.12727346,
-0.016248787,
-0.024856463,
0.038610462,
0.008261542,
0.009332603,
-0.00016531246,
0.022387797,
-0.02680266,
0.034300093,
-0.032706562,
-0.017136984,
-0.0039870916,
-0.03299392,
0.011481257,
0.007614986,
0.01105022,
0.027507994,
-0.009051776,
0.021473477,
0.010325294,
0.01029264,
-0.011344109,
-0.004137302,
0.0183256,
-0.0007612537,
-0.021186119,
0.023863772,
0.032889426,
0.015125479,
-0.010214269,
-0.016862689,
0.020402415,
0.0009151372,
0.013662565,
-0.0068965913,
0.006236974,
-0.029989721,
0.024817279,
-0.022544539,
-0.019893007,
0.0035168696,
0.016314095,
-0.0064328997,
-0.024307871,
0.00047348754,
-0.018508466,
0.0025290765,
0.005156116,
-0.028814167,
-0.03194898,
-0.028735796,
-0.01301601,
-0.012891923,
0.03443071,
-0.005139789,
-0.0066810725,
0.01279396,
-0.01846928,
0.010194677,
-0.00002363611,
-0.00013704608,
0.00601819,
0.014328713,
0.043025326,
0.015674071,
-0.03662508,
-0.033620883,
0.008738294,
-0.014420145,
0.017816193,
0.02287108,
-0.018351724,
-0.0290754,
-0.008307258,
0.0060965605,
0.0058549186,
-0.012095158,
-0.013662565,
-0.0011829025,
-0.019788515,
-0.018286416,
0.014825058,
-0.017672515,
0.013146627,
0.015700195,
0.016810441,
-0.0129637625,
0.021656342,
-0.03503155,
-0.00035511566,
0.030538315,
-0.0043005734,
-0.031896733,
-0.010488566,
-0.0069684307,
0.003905456,
0.019958317,
0.0073080356,
0.0048752893,
-0.04686547,
-0.00870564,
-0.045089077,
0.019083181,
0.009097492,
0.0014612805,
0.017685577,
-0.009482813,
-0.0044997646,
-0.0060214554,
-0.010632245,
-0.0122976145,
-0.015687132,
-0.020768143,
0.016301034,
0.016261848,
-0.02550955,
-0.027795352,
0.0493472,
-0.018142737,
0.007712949,
0.023981329,
-0.008672986,
0.021969823,
-0.009273825,
0.0063284063,
-0.02831782,
-0.021656342,
-0.025692414,
-0.0011502482,
-0.018495403,
-0.009077899,
-0.0043005734,
-0.030747302,
0.0039315796,
0.02315844,
-0.0075496775,
-0.025679352,
0.0063218754,
0.0047936533,
0.016993305,
0.029623995,
-0.03414335,
-0.026136514,
0.028448438,
0.0037323881,
-0.008346443,
-0.025744662,
-0.025013205,
-0.00060410483,
-0.0005436943,
-0.029623995,
0.027142266,
0.011135121,
0.000042221007,
-0.0075627393,
-0.025640167,
-0.007151295,
-0.0048785545,
0.005818999,
-0.0066190297,
-0.0007624782,
0.03194898,
0.0140674785,
0.0031021598,
0.00038389227,
-0.0073210974,
0.010854294,
-0.019945255,
0.0012098424,
-0.0056491964,
0.0072557884,
-0.024412366,
0.02014118,
0.025927525,
0.017319849,
0.006364326,
0.0030401167,
-0.005949616,
-0.00938485,
-0.0058941036,
0.01605286,
0.0337515,
-0.015935306,
-0.0072623193,
0.023432735,
0.029702364,
-0.009175862,
-0.00014245445,
0.033333525,
-0.004718548,
0.005845122,
-0.0095873065,
0.021969823,
0.010802047,
0.012258429,
0.019775452,
0.018403972,
-0.027638612,
0.027795352,
0.024738908,
0.024778094,
-0.01142901,
0.0062239124,
0.007477838,
-0.019422786,
-0.026423872,
0.0080199,
-0.035658512,
-0.025378933,
-0.019866886,
0.010455911,
-0.0061194184,
0.004705487,
0.015047108,
-0.017215354,
-0.011984133,
0.023824587,
-0.006684338,
-0.017463528,
0.0050157025,
0.011011034,
0.021786958,
0.014655256,
0.012375985,
-0.0007302321,
0.0073341588,
-0.005358573,
0.024960957,
-0.025091575,
-0.002320089,
-0.011703306,
0.0219437,
-0.01641859,
-0.02443849,
0.010377541,
-0.017999059,
-0.015843874,
-0.010037936,
0.029258266,
-0.017045552,
0.074295096,
-0.014642195,
-0.004463845,
0.0017078206,
-0.002135592,
0.009424035,
-0.0072557884,
0.015412836,
-0.00035001343,
-0.038636584,
0.023223748,
-0.01801212,
0.028056586,
-0.027377376,
-0.01619654,
0.007908875,
-0.02884029,
0.017019428,
-0.01165106,
-0.0027168388,
0.02082039,
-0.025405057,
0.017241478,
0.020167304,
-0.01597449,
0.0246736,
0.02831782,
-0.0072623193,
0.0152038485,
-0.0047120177,
0.007863159,
-0.020036686,
-0.06807771,
-0.014093602,
-0.013780121,
-0.007477838,
-0.0003255227,
-0.025326686,
-0.009548121,
0.028291699,
-0.003079302,
0.0064688195,
-0.008509714,
-0.001151881,
-0.0014147481,
-0.01007059,
-0.021068564,
-0.02831782,
-0.015700195
] |
The pancreas emerges independently from dorsal and ventral domains of embryonic gut endoderm. Gene inactivation experiments in mice have identified factors required for dorsal pancreas development, but factors that initiate the ventral pancreas have remained elusive. In this study, we investigated the hypothesis that the emergence of the ventral pancreas is related to the emergence of the liver. We find that the liver and ventral pancreas are specified at the same time and in the same general domain of cells. Using embryo tissue explantation experiments, we find that the default fate of the ventral foregut endoderm is to activate the pancre | [
0.005614565,
-0.021665463,
0.014673251,
-0.024407763,
-0.014296346,
-0.0029957343,
-0.033479445,
-0.0075380737,
-0.025148574,
-0.0064398544,
0.0112941135,
0.010468825,
0.0124313235,
0.015349078,
-0.01240533,
0.0014686247,
0.028696667,
-0.0102478815,
-0.0028933857,
0.0047145453,
-0.011326605,
-0.01632383,
0.0043343925,
-0.0065438277,
0.0061344323,
-0.00739511,
0.009754008,
-0.018715218,
-0.02438177,
-0.014075403,
-0.000032161704,
0.021275563,
-0.0180004,
-0.0069077346,
0.0031793125,
0.018832188,
-0.0069207316,
-0.0038210235,
0.012145396,
-0.0042564124,
0.012996679,
0.0029080068,
0.0007586811,
0.023095097,
-0.016791709,
0.014036413,
-0.0074600936,
-0.008272386,
-0.020248825,
0.014881197,
-0.005273402,
0.015011164,
-0.020612732,
-0.014413317,
-0.029398488,
0.0018244088,
-0.011904958,
0.027085079,
0.0006092193,
-0.015284094,
-0.002547349,
-0.0066867913,
-0.0019901164,
0.013094154,
-0.013620519,
0.035402954,
-0.023420015,
-0.011891961,
0.0066932896,
0.019001145,
0.045488376,
0.0010551679,
-0.006374871,
-0.0057802727,
0.011872466,
-0.007856492,
-0.035558913,
-0.0064658476,
-0.015401064,
0.027189052,
-0.0048185186,
-0.02809882,
-0.017428545,
0.048477612,
0.031321995,
-0.020586738,
0.012788732,
0.020560745,
-0.018520268,
-0.0035480934,
-0.0055625783,
0.034545172,
0.021795431,
0.012853716,
-0.0092081465,
-0.014933184,
0.0017009403,
0.03176388,
-0.011859469,
-0.054794,
-0.016609756,
0.012437821,
-0.021379536,
-0.016531775,
-0.01482921,
0.016934672,
0.0076095555,
-0.009786499,
0.027630938,
-0.0048575085,
-0.009773502,
0.040237717,
0.002261422,
-0.01784444,
0.015297091,
-0.017012652,
0.011222632,
0.03675461,
-0.017870434,
0.0054813493,
0.02085967,
-0.0041069505,
0.01060529,
-0.031399976,
0.03389534,
0.017441543,
-0.0042824056,
0.002672442,
-0.0043181465,
-0.014153383,
0.007375615,
-0.010325861,
0.013308599,
0.011586539,
-0.019066127,
0.0086103,
-0.028696667,
-0.00034786423,
-0.025889384,
-0.047905758,
-0.0049517346,
0.027267031,
-0.019949902,
0.0029859869,
-0.021860413,
0.010949702,
0.017129622,
0.008863735,
0.0059654755,
0.01811737,
0.007642047,
-0.019248081,
-0.017233595,
-0.019689968,
0.030204281,
0.010273875,
-0.016297836,
0.03545494,
0.010111416,
0.011573543,
0.006394366,
-0.012281861,
0.0008902725,
0.0057120402,
0.03792431,
0.03306355,
0.03267365,
0.0040322198,
0.008525821,
-0.015829954,
-0.009442087,
0.022276307,
-0.025265543,
0.0022289304,
-0.00023515866,
0.027578952,
-0.0044936016,
-0.0031841863,
-0.03615676,
-0.004129695,
-0.009097675,
-0.0029258772,
-0.003486359,
0.012450818,
-0.01768848,
-0.0075900606,
0.0068882396,
-0.018364307,
0.0037008042,
-0.030438222,
-0.0029469968,
0.010501317,
0.013165636,
0.012047921,
-0.6375651,
-0.011333104,
0.040289704,
-0.01753252,
-0.00085128244,
0.034935072,
-0.018208347,
-0.016882686,
-0.003388884,
-0.00027922553,
-0.023316042,
0.014777224,
0.039587885,
-0.01455628,
-0.015427058,
-0.022952134,
-0.0034928573,
-0.017129622,
0.020794686,
-0.007050698,
-0.016791709,
0.010813237,
-0.005188924,
0.016349822,
-0.0050134687,
0.018871177,
0.04018573,
-0.006426858,
-0.011300612,
0.002899884,
-0.010943203,
-0.0011924453,
-0.01033236,
-0.007024705,
0.0344412,
-0.00039842943,
-0.015868945,
0.02265321,
0.0021574486,
0.056925453,
0.004483854,
0.020326806,
0.019936904,
0.02202937,
-0.03103607,
-0.0059622265,
0.03714451,
0.0037560402,
0.008265887,
0.004558585,
0.0012200632,
-0.005055708,
-0.01862424,
-0.0031744388,
-0.0078045055,
-0.014569277,
0.030464215,
-0.023900893,
0.014777224,
-0.0013589652,
0.0037787843,
0.025993358,
-0.010000944,
-0.015738977,
0.0023459005,
0.011580041,
0.00055398344,
0.0055495817,
0.0053513823,
-0.0010421711,
-0.00622216,
0.01479022,
-0.0023897644,
0.025408506,
0.03792431,
0.02438177,
0.007811004,
0.01068327,
-0.014621263,
0.022159338,
-0.003847017,
0.015466047,
-0.0032118042,
0.011852971,
0.021665463,
-0.025460493,
-0.021977384,
0.007375615,
0.0029989837,
0.019417038,
0.017168613,
0.02210735,
-0.010397343,
-0.0138024725,
-0.017285584,
0.043045,
-0.008688279,
0.013516546,
0.0021850667,
-0.01807838,
0.0022792926,
-0.016973663,
0.02488864,
-0.013386579,
0.029684415,
0.007914977,
-0.03646868,
0.004867256,
0.024316786,
-0.02958044,
-0.0062514027,
-0.007927974,
-0.0031013326,
-0.008090433,
0.019949902,
-0.028514713,
0.0101504065,
-0.011664519,
-0.0069792164,
-0.009052187,
0.0014905566,
-0.030854115,
0.025915377,
-0.01107317,
0.002050226,
0.012691257,
-0.0072326516,
-0.025330527,
0.002230555,
0.0050069704,
0.005731535,
0.000035410874,
0.004675555,
-0.022406274,
0.02121058,
0.011755496,
0.008252891,
0.008239894,
-0.02093765,
-0.02598036,
-0.024563722,
-0.018299324,
-0.01279523,
-0.013003177,
-0.022562234,
-0.016102886,
-0.01803939,
0.006576319,
0.00095606816,
0.017974406,
0.017155616,
-0.0058127646,
-0.015102141,
0.0037008042,
0.044006754,
-0.00014428345,
0.013659509,
-0.0203528,
0.0071286783,
-0.0079344725,
0.010416838,
0.014270353,
-0.0040874556,
0.003213429,
-0.02473268,
-0.022705197,
-0.015985915,
0.0032150534,
0.000070212525,
-0.035740867,
-0.0043733823,
0.0049874755,
0.017792454,
0.024667697,
0.010930207,
0.0007895482,
0.0064398544,
-0.020560745,
-0.003924997,
-0.004977728,
0.0029616181,
-0.017389556,
0.0140624065,
0.0044708573,
0.027630938,
-0.011151151,
0.015894938,
0.032543685,
-0.012151894,
0.019715961,
-0.008187908,
0.011079669,
-0.0025132326,
0.022510247,
-0.0019738707,
-0.020248825,
0.010059429,
0.025486488,
-0.011216134,
0.025928374,
0.008434844,
-0.009968452,
-0.0067387777,
-0.021587484,
0.011645024,
-0.030230274,
0.0044351164,
-0.011060174,
-0.018806195,
-0.004844512,
-0.0009918091,
-0.005208419,
0.0012273738,
-0.031218022,
0.0053156414,
-0.0076550436,
0.00032146473,
-0.03485709,
-0.013022672,
-0.0012558041,
0.0067127845,
-0.007895483,
0.00731713,
0.0050817016,
-0.020209836,
0.026877131,
-0.013386579,
0.0033239005,
-0.004844512,
-0.057497308,
0.0114240805,
0.016258845,
-0.006127934,
-0.00048818774,
0.022835165,
0.017584506,
-0.0018617742,
-0.0053708777,
0.005591821,
0.0048315153,
0.022952134,
0.014972174,
-0.0075770635,
0.026331272,
-0.010475323,
-0.0183903,
0.0034798607,
-0.017571509,
-0.02273119,
0.0066867913,
0.007271642,
0.015583018,
0.010819735,
0.0029794886,
0.020092865,
-0.017272586,
-0.000344412,
-0.019988893,
0.024433756,
0.027890872,
0.001305354,
-0.01940404,
-0.0009593174,
-0.008311376,
0.019780945,
-0.005403369,
-0.0037462926,
-0.0010641031,
0.0009991197,
-0.0006880117,
-0.015583018,
-0.013451562,
0.027319018,
-0.015557025,
0.004964731,
0.010546804,
0.008077436,
-0.010767749,
0.022705197,
0.005975223,
-0.00009574897,
-0.03670262,
0.0344412,
0.02136654,
-0.0180004,
-0.012255868,
-0.0043766317,
-0.013243616,
0.00692723,
0.024225809,
0.030178288,
0.010754752,
0.034363218,
-0.01663575,
-0.016843695,
-0.026929118,
0.013386579,
-0.026006354,
0.02234129,
-0.007271642,
-0.010319363,
0.0072066584,
-0.019832931,
-0.020599736,
0.043980762,
0.023497995,
-0.0016603257,
-0.026981104,
0.0057185385,
-0.008831243,
-0.013919443,
-0.02222432,
0.005689296,
-0.020833677,
0.0010023689,
-0.006433356,
0.008980705,
0.019910911,
0.042551126,
0.011287616,
-0.031919844,
-0.025889384,
-0.0031451962,
-0.006816758,
0.01455628,
0.025902381,
-0.0038567644,
0.010124412,
-0.011014685,
-0.011437077,
0.0016619503,
-0.030932095,
0.02183442,
-0.00053854985,
0.0024563724,
-0.011092666,
0.0035188508,
0.0032930335,
0.02578541,
0.007141675,
-0.02445975,
-0.036104772,
-0.0071871635,
-0.017896427,
-0.0031045817,
-0.005175927,
0.029008588,
0.02234129,
0.0006697351,
0.01146307,
-0.00326704,
0.017194606,
-0.0057510305,
-0.0016895683,
-0.00438313,
0.016544772,
0.0061181863,
0.0012907326,
0.0073431237,
-0.03537696,
0.021899404,
0.013906446,
-0.0019511264,
0.027994847,
0.0047145453,
0.014608267,
0.0063163857,
-0.010572799,
0.0022630468,
-0.016804706,
-0.011982937,
0.011495562,
-0.0030525948,
-0.01690868,
0.014582274,
-0.025018606,
0.011086167,
-0.02481066,
0.016661743,
0.016427802,
0.008168412,
0.00058525667,
-0.008031948,
0.0004341703,
0.008051443,
-0.012424825,
-0.022003377,
0.0028982593,
0.008311376,
-0.012931695,
-0.0058290106,
-0.013003177,
-0.02566844,
-0.014218367,
-0.0023816414,
-0.019287072,
-0.012580785,
0.0013086031,
0.0031728141,
0.018637238,
0.022991125,
-0.015453051,
0.032309745,
0.022510247,
0.03337547,
-0.030256268,
0.010754752,
-0.019131111,
-0.006946725,
0.0054683527,
0.017636493,
-0.020014886,
0.006875243,
-0.008369861,
0.010904213,
0.015089144,
0.0031159536,
0.007349622,
-0.005803017,
-0.003996479,
0.02367995,
0.016128879,
0.00536113,
-0.018884175,
-0.01854626,
-0.022679204,
-0.014452307,
-0.017753463,
-0.013373583,
-0.013685503,
0.0012476812,
-0.0025424752,
-0.015154127,
-0.017870434,
0.009916466,
0.01091721,
0.021353543,
0.013880453,
0.025525477,
0.020599736,
-0.013516546,
0.005705542,
0.0040127244,
-0.003044472,
-0.01424436,
-0.0068297544,
0.02105462,
0.010819735,
-0.020261822,
0.024030859,
0.013646512,
-0.008174911,
-0.042681094,
-0.0013232244,
0.007849994,
0.033245504,
0.008187908,
-0.022380281,
-0.011242127,
0.0014734984,
0.011177144,
0.0071871635,
-0.013464559,
-0.027319018,
-0.017571509,
0.009656533,
-0.0072586453,
-0.023965875,
0.03919798,
-0.037976295,
0.0013419071,
0.008070937,
0.0003096865,
0.010780745,
-0.009370605,
0.006092193,
-0.0057380334,
-0.0011672642,
-0.023861902,
-0.034363218,
-0.01416638,
-0.033505436,
0.019689968,
0.023796918,
0.013152638,
0.005838758,
0.008369861,
0.029398488,
0.007616054,
0.03431123,
-0.012756241,
0.035117026,
-0.011021184,
0.03485709,
0.006914233,
0.0028040335,
0.018975152,
0.004038718,
0.035402954,
0.022289304,
0.01107317,
-0.006397615,
0.0056568044,
-0.035662886,
-0.028670674,
-0.008902725,
0.0028868872,
-0.015596014,
-0.028852627,
-0.016193861,
0.009084678,
-0.01126812,
0.003635821,
-0.024797663,
0.023095097,
-0.027864879,
0.03841818,
0.016505782,
0.010429835,
-0.014569277,
-0.020690713,
0.004750286,
-0.033609413,
0.00363907,
-0.002269545,
0.010046433,
0.020326806,
-0.020027881,
-0.0024953624,
0.016765716,
-0.0098254895,
0.017740466,
-0.0021152094,
-0.012925197,
-0.01037135,
-0.015751975,
0.0054521067,
-0.042369172,
-0.0033628906,
0.003944492,
0.0015116762,
0.018208347,
-0.013009676,
-0.029450474,
-0.005231163,
-0.0025343522,
0.030334247,
-0.0068037612,
0.029372495,
0.0504791,
-0.010624785,
-0.022393277,
-0.026877131,
0.008369861,
0.0037885318,
0.027397,
0.011313609,
0.007369117,
-0.007583562,
0.007862991,
0.0281768,
-0.00360008,
-0.03337547,
0.009624041,
-0.010780745,
-0.030958088,
-0.0139324395,
-0.0027439238,
0.001025113,
0.013880453,
-0.01741555,
0.007947469,
-0.01710363,
-0.0053708777,
-0.0098904725,
0.010754752,
-0.010514313,
0.0172206,
-0.007694034,
0.002805658,
0.013724493,
-0.003028226,
-0.020300813,
-0.0006502401,
0.020768693,
-0.0009211396,
-0.023822913,
0.003674811,
-0.0054456084,
0.0034148772,
-0.010832732,
-0.002935625,
-0.014803217,
0.039301958,
0.012034925,
-0.015842952,
0.014530287,
-0.007245648,
0.016141875,
-0.0044513624,
0.0020242326,
-0.017974406,
-0.010546804,
-0.0026172062,
0.028202793,
0.020963643,
0.017077636,
0.0034733624,
-0.020911656,
-0.01815636,
-0.036494672,
-0.03306355,
-0.03587083,
-0.019949902,
0.017350566,
0.007245648,
0.0070636948,
-0.0024596215,
0.00059662876,
-0.0003547687,
-0.008051443,
0.016102886,
-0.008122924,
0.009942459,
-0.009370605,
0.0010048057,
-0.0367806,
-0.0028202792,
0.0000041629987,
-0.029996334,
0.008675283,
-0.05149284,
-0.0026838141,
0.012827722,
-0.013685503,
-0.0045650834,
0.000622216,
0.00084072264,
-0.010384346,
0.018845184,
0.018975152,
-0.0017919171,
-0.0118139805,
0.028592693,
-0.02265321,
-0.017285584,
-0.0055073425,
0.0015506663,
-0.02253624,
-0.010163403,
-0.0031906846,
-0.012944692,
-0.017259588,
-0.027397,
-0.027812893,
0.016869688,
-0.011333104,
0.0023459005,
-0.028540706,
-0.013659509,
-0.023549981,
0.0011242128,
0.011040678,
-0.044084735,
-0.017051643,
0.015076147,
0.00094550836,
-0.011242127,
0.0007842683,
-0.013529543,
0.012983682,
-0.025421504,
-0.021496506,
0.007271642,
-0.025408506,
0.057809226,
0.023225065,
-0.0045455885,
-0.008174911,
0.014673251,
-0.023809915,
-0.013646512,
0.021626474,
0.033973318,
0.005403369,
-0.0029827377,
-0.011411084,
-0.00090408145,
-0.022848161,
0.012164892,
-0.0164408,
-0.023770925,
0.0030022329,
-0.005546333,
0.036442686,
-0.00739511,
-0.0073041334,
-0.027656931,
0.017272586,
0.0072586453,
-0.0066867913,
0.0052181664,
-0.023485,
0.03467514,
-0.048113704,
0.028280772,
0.025915377,
0.005630811,
0.030594181,
-0.030906102,
-0.023199072,
0.0012817974,
-0.019222088,
0.011216134,
0.00071847264,
0.013581529,
0.0035675883,
0.008207402,
-0.0024807411,
0.00003932003,
0.043876786,
0.0014686247,
0.005318891,
0.00064942776,
0.023342036,
0.0053546317,
0.031399976,
-0.000047772948,
-0.026981104,
-0.013828466,
-0.008837742,
0.014231363,
-0.0019901164,
-0.011365595,
0.0017870433,
-0.019637981,
-0.000677858,
-0.02887862,
0.0023312792,
-0.015998911,
0.017987404,
-0.015349078,
0.027267031,
-0.0029908607,
0.012587284,
-0.011710008,
0.011359097,
-0.018780202,
-0.022991125,
-0.008655788,
0.0062189107,
0.015154127,
-0.0048575085,
-0.01420537,
-0.014816213,
0.00079726503,
0.009234141,
-0.019780945,
-0.027994847,
0.0010787243,
0.19224687,
-0.018143363,
0.0079669645,
-0.013113649,
0.006075947,
-0.017428545,
0.000830569,
0.0024173823,
-0.005416366,
0.006072698,
-0.016193861,
0.005052459,
-0.014075403,
0.0017707975,
0.038106263,
-0.008317875,
-0.028358754,
-0.0016700733,
-0.003252419,
-0.0062643993,
0.005055708,
-0.038132254,
-0.008746765,
0.022640215,
0.04125146,
-0.0021736945,
-0.026721172,
0.017168613,
0.023134088,
0.024615709,
-0.0047827777,
-0.0054878476,
-0.010949702,
0.026747165,
-0.012879709,
-0.016193861,
-0.0023134088,
-0.007466592,
0.015531031,
0.0049062464,
-0.0076355487,
-0.00731713,
0.031062063,
0.0019836181,
-0.010078925,
0.021899404,
0.010364851,
-0.013880453,
0.030230274,
-0.0012314353,
-0.02997034,
0.01651878,
0.046866022,
0.01263927,
-0.029320506,
-0.012847217,
0.022588227,
-0.0032036812,
0.011443576,
0.035013054,
-0.017740466,
0.020378793,
-0.027422993,
0.02105462,
-0.01048832,
0.028228786,
0.012210379,
-0.008889728,
0.017506527,
-0.03220577,
0.010728759,
-0.0056827976,
-0.019183097,
0.0141923735,
-0.0019933656,
-0.011625529,
0.031997822,
0.009780001,
0.016414804,
0.0073626186,
0.006992213,
0.01091721,
-0.035558913,
-0.0027682926,
-0.012756241,
-0.016843695,
0.008486832,
0.0070896884,
-0.0035318474,
-0.019845929,
-0.01803939,
-0.021106606,
-0.00074933976,
-0.031425968,
0.016024904,
-0.013919443,
0.013763483,
0.025707431,
-0.004366884,
-0.0057120402,
-0.0058939937,
0.03753441,
0.019456029,
-0.0091106715,
-0.0005783522,
0.00040980152,
-0.019624986,
0.020378793,
-0.003808027,
0.0014767476,
0.009500572,
0.0068037612,
-0.000269478,
-0.006946725,
-0.016258845,
0.038730104,
0.017389556,
-0.011703509,
0.0053513823,
0.0046625584,
-0.010026937,
-0.011235629,
0.017558513,
0.007180665,
0.011144652,
0.0069662197,
-0.011008187,
0.010715761,
0.017766459,
-0.024212813,
-0.014972174,
-0.03111405,
-0.0003691869,
0.022575231,
-0.007811004,
-0.006751775,
0.000566574,
-0.0062351567,
-0.02406985,
0.025577463,
-0.010891217,
-0.0037008042,
0.041303445,
0.008967708,
0.009559058,
-0.024134832,
0.03384335,
0.0029941099,
-0.026929118,
-0.0037560402,
-0.017077636,
-0.019053131,
-0.017207602,
-0.0141273895,
0.021782434,
-0.027526965,
-0.0056990436,
-0.041173477,
0.011697011,
-0.0075770635,
-0.011346101,
0.01432234,
-0.0023182826,
0.0003466458,
0.00845434,
-0.020924652,
-0.1615747,
-0.0015327958,
0.011248626,
-0.010462326,
0.031425968,
0.026240295,
-0.0049452363,
0.014309343,
0.008096931,
0.018858181,
0.047047976,
0.0048152693,
-0.058693003,
-0.017155616,
0.009929462,
0.026305277,
-0.0137374895,
0.033765372,
0.02625329,
-0.005247409,
0.03392133,
-0.0137374895,
0.035013054,
0.011450074,
-0.0052604056,
0.0136075225,
0.0004772218,
-0.020196838,
-0.014114393,
-0.018091377,
0.008512825,
0.01607689,
0.04073159,
-0.0051044454,
0.013594526,
-0.016024904,
-0.0033401465,
-0.014647257,
-0.002922628,
0.005153183,
0.019754952,
0.027500972,
-0.0017724221,
-0.00047153575,
-0.002038854,
0.02833276,
-0.03329749,
0.014218367,
0.02418682,
-0.00356109,
0.009896971,
-0.008213901,
0.0016993157,
0.024563722,
0.021977384,
0.008967708,
0.012606778,
0.014894194,
0.0039834823,
0.004175183,
0.029320506,
-0.010436333,
0.028150806,
0.026903125,
0.0076810373,
-0.027552959,
-0.006706286,
0.02997034,
-0.03592282,
-0.011333104,
-0.029424481,
-0.021743443,
0.0044676084,
-0.016232852,
0.005864751,
0.009591549,
-0.015401064,
-0.01788343,
0.00536113,
0.011852971,
-0.001780545,
-0.020131856,
-0.026747165,
-0.017597502,
-0.028462727,
0.0203528,
-0.00442212,
0.016388811,
0.005484598,
0.0011363971,
0.015440054,
-0.040627617,
-0.0079669645,
-0.02175644,
0.008200904,
0.02919054,
-0.014504294,
-0.0025912127,
-0.0024904886,
0.0077850106,
0.028072827,
0.0044513624,
-0.037742354,
0.019482022,
0.014673251,
0.0012606778,
-0.04676205,
-0.0058874954,
0.061292335,
-0.01240533,
-0.008831243,
0.004324645,
0.018520268,
0.0024969869,
-0.017311577,
0.025447497,
-0.011723004,
-0.0039477414,
0.026955111,
-0.034025304,
0.04335692,
-0.00040817694,
0.027085079,
0.039665863,
0.011950446,
-0.023446009,
-0.12144097,
-0.055313863,
0.021925397,
0.024875643,
-0.012242871,
0.01076125,
-0.011255124,
0.0120739145,
-0.0036488175,
0.015284094,
-0.026721172,
-0.018403297,
-0.008109927,
-0.033219513,
0.029320506,
0.002535977,
0.012840719,
-0.0028154056,
-0.02989236,
0.023653956,
-0.003924997,
-0.01881919,
-0.00062790205,
-0.017402552,
-0.008174911,
0.0100204395,
-0.021496506,
0.009227642,
0.013984426,
0.006010964,
0.014816213,
-0.011333104,
0.030022329,
-0.0007339062,
-0.007427602,
-0.02496662,
-0.004272658,
-0.018806195,
0.032699645,
0.0068882396,
0.0064463527,
-0.019702965,
0.0036065783,
-0.0336614,
-0.013776479,
-0.0036650633,
-0.022302302,
-0.008636293,
0.0041329437,
-0.026825145,
-0.015492041,
-0.029398488,
-0.008629794,
-0.0138674565,
0.009091177,
-0.019547004,
0.013841463,
-0.00041183227,
0.0062514027,
-0.009214645,
0.0046885516,
-0.008330871,
-0.007603057,
-0.0049354886,
0.0180004,
0.004730791,
-0.019430034,
-0.03956189,
0.023510993,
-0.037274476,
0.005728286,
-0.0024709934,
0.004363635,
-0.0056178146,
-0.03384335,
0.00074487214,
-0.013165636,
0.023809915,
-0.010306366,
-0.016232852,
0.013113649,
-0.01796141,
0.0069662197,
0.00087727583,
0.026149318,
0.026006354,
0.039223976,
-0.0094355885,
0.003388884,
-0.01796141,
-0.020092865,
0.03176388,
0.018598247,
-0.022172334,
-0.015712984,
0.008506326,
0.032777622,
-0.009942459,
0.008694778,
0.0046788044,
-0.004324645,
0.0049712295,
-0.050037213,
-0.01350355,
-0.018481277,
-0.0036715618,
0.017987404,
0.009500572,
0.009149662,
-0.008337369,
0.0037592894,
0.025265543,
0.005689296,
0.00622216,
-0.0000893014,
-0.013776479,
-0.020989636,
-0.013568533,
0.022939138,
0.0015880316,
0.0118789645,
0.022523245,
-0.0017837941,
0.0050687045,
0.008447841,
0.00014245578,
-0.017207602,
0.011664519,
-0.024420759,
0.012359842,
0.012346845,
-0.028618686,
-0.003486359,
-0.034753118,
-0.0118789645,
0.021314554,
-0.008759761,
-0.005416366,
-0.009754008,
-0.0060207113,
0.035428945,
0.03841818,
-0.0031874354,
-0.03919798,
0.001410952,
-0.0164408,
0.0039152494,
-0.00034928575,
-0.023446009,
0.0066185584,
-0.010234885,
-0.0028543957,
0.027734913,
0.013107151,
-0.0062546516,
0.0009552559,
-0.0011908207,
0.0031760633,
0.0026155815,
-0.009221144,
-0.012866712,
-0.02445975,
0.027397,
0.012951191,
0.012658766,
-0.0031354488,
-0.0024937377,
-0.011151151,
-0.028306765,
-0.010260878,
0.017207602,
0.0014239486,
-0.016505782,
-0.007986459,
0.010397343,
0.029086567,
0.023588972,
-0.010384346,
-0.02872266,
0.023420015,
-0.018780202,
0.046502117,
0.013159137,
0.012489809,
-0.01780545,
0.014114393,
0.048295658,
0.01920909,
-0.004558585,
0.0034311232,
-0.012034925,
0.016453795,
-0.009955456,
0.008051443,
-0.023562979,
0.007421104,
-0.0119764395,
-0.0018487775,
-0.0033271497,
0.0018926413,
-0.006469097,
0.01807838,
-0.02399187,
0.007180665,
-0.0008325997,
-0.025057597,
-0.015531031,
0.0082204,
-0.011092666,
-0.03407729,
-0.007375615,
-0.014868201,
0.013841463,
-0.00114452,
-0.0011242128,
0.0027033093,
-0.015985915,
0.0049452363,
-0.022042368,
-0.034649145,
-0.0041784323,
0.019560002,
0.020573743,
0.005097947,
-0.0066153095,
-0.03165991,
-0.0121324,
0.012099908,
0.034025304,
-0.023757929,
0.030542195,
-0.0009918091,
0.01764949,
0.011723004,
-0.0121324,
-0.017246593,
-0.023952879,
-0.019430034,
0.0049614822,
0.0076355487,
-0.0058062663,
0.088689335,
-0.0055495817,
-0.02121058,
-0.0011900084,
-0.008558313,
0.023030115,
0.020235829,
0.011125157,
-0.014933184,
0.008142419,
0.030412229,
-0.009149662,
0.02555147,
-0.030308254,
-0.021665463,
0.014712241,
-0.009396599,
0.0009552559,
0.011151151,
-0.015271097,
0.023459004,
-0.017558513,
0.011177144,
0.027371006,
-0.05016718,
0.00045569605,
0.017402552,
0.016141875,
0.017740466,
-0.015089144,
0.013568533,
-0.009162659,
-0.060980417,
0.015816959,
0.012099908,
0.016505782,
-0.017792454,
-0.014504294,
0.010039934,
0.02535652,
0.006374871,
0.0051726783,
-0.00563406,
-0.00037243607,
-0.015933929,
-0.019248081,
-0.009773502,
0.0060954425,
-0.02617531
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.