text
stringlengths 174
850
| embeddings_A
sequence |
|---|---|
Background: Vascular calcification (VC), in which vascular smooth muscle cells (VSMCs) undergo a phenotypic transformation into osteoblast-like cells, is one of the emergent risk factors for the accelerated atherosclerosis process characteristic of chronic kidney disease (CKD). Phosphate is an important regulator of VC. Methods: The expression of different smooth muscle cell or osteogenesis markers in response to high concentrations of phosphate or exogenous bone morphogenetic protein 2 (BMP-2) was examined by qRT-PCR and western blotting in rat VSMCs. Osteocalcin secretion was measured by radio | [
-0.015530705,
-0.017493594,
0.011684502,
-0.019933945,
-0.019536061,
0.027772242,
-0.029735133,
-0.0065982286,
-0.025716513,
0.0010560482,
0.021273484,
-0.00028887973,
0.0033919537,
0.00034089468,
-0.020000258,
-0.000949946,
0.028780214,
-0.012937834,
0.012427216,
0.006057771,
-0.017453806,
0.022268193,
0.008408597,
-0.02350163,
-0.001197794,
0.009297202,
0.00837544,
-0.035729907,
-0.009502776,
-0.025517572,
0.014801253,
0.0019347067,
-0.004953645,
-0.013488239,
-0.0075067286,
0.014681888,
-0.013242877,
-0.01651215,
0.0164591,
-0.008017345,
0.008382072,
-0.009502776,
0.007142002,
-0.008289232,
-0.0021353061,
-0.02163158,
0.009071736,
-0.010026655,
-0.017108975,
0.02106128,
0.02986776,
0.013673917,
0.02106128,
0.014628837,
-0.00904521,
0.002470191,
0.021074543,
0.006528599,
0.012546581,
-0.016352996,
0.006001404,
0.014098326,
-0.012738892,
-0.008527962,
-0.015477654,
0.0069032726,
-0.013700442,
0.024045404,
0.021074543,
0.0048641213,
0.020849077,
0.013481607,
-0.0060610864,
-0.0030239117,
0.023819936,
-0.01669783,
-0.031406242,
-0.0030703316,
-0.018368939,
0.009681823,
-0.0043733986,
-0.021525478,
-0.012453742,
0.03660525,
0.014376844,
0.0079178745,
-0.016618252,
0.013700442,
-0.0066214385,
-0.005679782,
0.024376974,
0.03249379,
0.0013594341,
-0.0016818852,
-0.026379652,
-0.014018749,
-0.00461876,
0.024615703,
0.013581078,
-0.020318566,
-0.0076924074,
0.014535997,
-0.013037304,
-0.025305368,
-0.07029269,
0.008939108,
-0.010020023,
0.007294524,
0.03445668,
-0.00028369896,
-0.011505454,
0.04302443,
0.0070359004,
-0.039310854,
0.031512346,
-0.017002873,
0.0059284586,
0.008342283,
0.0079178745,
-0.005116114,
0.009303834,
0.012281327,
0.025902193,
-0.01852809,
0.011989545,
-0.003106804,
-0.014734939,
0.0022032778,
-0.03029217,
-0.0076260935,
0.0053780535,
0.0024022195,
-0.0074138893,
0.008362177,
-0.034271,
-0.017321179,
-0.022215141,
-0.01986763,
-0.029071994,
-0.04010662,
-0.009986867,
0.015729647,
-0.015146085,
0.0040418296,
-0.008395334,
0.007533254,
0.024443287,
0.027188681,
0.010557166,
-0.02651228,
-0.0032858516,
-0.018342413,
0.011790603,
-0.0039158333,
-0.015782697,
-0.000053517353,
0.0014423263,
0.04244087,
-0.007871455,
-0.024191294,
-0.0062865536,
0.0008778297,
0.019151442,
0.0063727614,
0.022719128,
-0.0026508963,
0.02005331,
-0.023236375,
0.010703056,
-0.018673982,
-0.0171355,
0.019615639,
-0.0343771,
0.03498719,
0.008289232,
0.0074404147,
-0.011644714,
-0.009821082,
-0.036127787,
-0.02297112,
-0.021379588,
0.020066572,
0.026353126,
-0.0052189003,
0.0022082515,
0.014920617,
0.04742767,
-0.023674047,
-0.013110249,
-0.008733535,
0.012082385,
0.0058720917,
-0.027560038,
-0.02909852,
-0.6378862,
-0.035119817,
0.0069430606,
0.005341581,
0.04612792,
0.030822681,
0.011008101,
-0.021101069,
-0.018541355,
0.005285214,
-0.022201879,
0.028780214,
-0.0063628145,
-0.011790603,
-0.0012723971,
-0.030743103,
0.007062426,
-0.022719128,
0.018872924,
0.003670472,
-0.02407193,
-0.0014531023,
0.013992224,
0.030875731,
0.013322454,
0.027984448,
0.005344897,
-0.00665128,
-0.0015277055,
0.041804254,
-0.010205703,
0.015994903,
-0.007427152,
0.02489422,
0.05148608,
0.0023010909,
-0.020981705,
0.015093034,
0.0053017926,
0.022440609,
-0.014191166,
0.006090928,
0.017639486,
0.0031598553,
-0.035623804,
0.023342477,
0.015345027,
-0.006505389,
-0.014376844,
0.00014713386,
0.010033286,
-0.014589048,
-0.0065451777,
0.013886121,
0.009356885,
-0.022520186,
0.011094308,
-0.018541355,
0.0033720597,
0.010941787,
-0.001835236,
0.027029527,
0.004685074,
-0.024270872,
0.01431053,
0.015066508,
-0.017878216,
0.0030239117,
-0.0012052543,
-0.0040318826,
0.012931202,
0.020981705,
0.010809159,
-0.0014000513,
0.023912776,
0.029469877,
0.014297267,
0.010868841,
0.0016644777,
0.010033286,
-0.005116114,
0.019217756,
-0.0052719517,
0.001640439,
0.010835684,
0.011890074,
-0.04297138,
0.0011604925,
0.01354129,
-0.0037931525,
0.011909968,
-0.01565007,
-0.014814516,
-0.056021947,
-0.013276034,
0.01675088,
0.00986087,
0.023223113,
0.0061605573,
-0.030955307,
-0.045332152,
0.017414019,
-0.024774857,
0.028488433,
0.021658106,
-0.0023491683,
-0.03827636,
-0.016445836,
0.028355805,
-0.056870762,
0.016764143,
-0.00876006,
0.0042871907,
-0.031247089,
-0.012844994,
-0.019695215,
0.029018944,
-0.0063827084,
-0.0028448645,
-0.013859596,
-0.007095583,
-0.001952943,
0.0070756883,
-0.0021038072,
0.01636626,
0.0022281455,
-0.003096857,
-0.003280878,
-0.008673852,
-0.017387493,
0.0038395722,
-0.014535997,
0.032042854,
-0.025517572,
0.028196651,
-0.014416632,
0.0016271763,
0.014469683,
0.011903337,
-0.0250799,
0.00254811,
-0.015795961,
0.015199136,
-0.026220499,
0.001424919,
0.0032709308,
-0.0155439675,
0.007997451,
0.004244087,
0.01574291,
-0.009575721,
-0.027692666,
0.0021286749,
0.0052586887,
0.010809159,
0.0010112863,
-0.008872794,
-0.016246894,
-0.0022364347,
-0.013561184,
0.0013660655,
-0.011996177,
-0.016963085,
0.00423414,
0.01478799,
-0.019668689,
-0.028064024,
0.001856788,
-0.020875601,
-0.01244711,
0.0024585861,
-0.011797235,
-0.0002683639,
0.009635404,
-0.009157944,
0.021525478,
-0.005129377,
-0.018634195,
-0.025119688,
-0.01019244,
0.02038488,
-0.046578854,
-0.02053077,
-0.00096984016,
0.05575669,
0.004134669,
0.028541483,
0.009622141,
0.017546646,
0.03273252,
-0.013156669,
0.012573107,
-0.036313467,
0.0015036667,
0.0117043955,
-0.031220563,
0.0058953017,
0.010218965,
0.023077222,
0.027533513,
0.034774985,
0.009303834,
0.022228405,
-0.0062434496,
0.0020457825,
-0.021034755,
-0.010344962,
0.012321115,
0.044032402,
0.028541483,
0.001079258,
0.019416697,
-0.0012309509,
-0.014217691,
0.008382072,
-0.010311805,
0.0038362567,
-0.024628967,
0.00751336,
-0.0048939628,
0.005785884,
-0.016896771,
0.03636652,
-0.014960406,
-0.02397909,
0.033183455,
-0.0004952816,
0.041035015,
0.00079037825,
-0.008116816,
-0.011850286,
0.026857112,
0.0029310724,
-0.030318694,
0.015636807,
0.012791943,
0.019735003,
-0.003312377,
0.017772114,
0.014960406,
0.013780019,
0.021366324,
0.014191166,
0.010829053,
0.0034184793,
-0.024735069,
0.027056053,
0.0051094824,
0.0024967168,
0.010344962,
0.012533319,
-0.0064888108,
-0.020265514,
0.01177734,
-0.00005812824,
-0.0010195755,
0.017931268,
0.028143601,
0.030133016,
0.00524211,
0.013740231,
0.011797235,
-0.00126245,
0.0006735001,
0.00092010474,
0.031644974,
-0.000020205003,
-0.013030672,
-0.01618058,
0.0025298735,
-0.026485754,
-0.0028349173,
-0.009754769,
-0.029761659,
0.003766627,
-0.0036207365,
0.031512346,
0.0038992548,
0.009615509,
0.019297332,
-0.0063860244,
-0.042149086,
-0.0011596635,
0.018130207,
-0.024761595,
-0.0035610541,
-0.023262901,
-0.002430403,
-0.008753429,
0.013276034,
-0.0065982286,
-0.00062293577,
-0.007069057,
-0.019032076,
-0.041220695,
0.0056698346,
0.010703056,
0.0015020089,
0.021034755,
-0.0043435576,
-0.005878723,
0.0013420266,
-0.012884783,
-0.018408727,
0.03217548,
0.012699104,
0.014058538,
0.00187834,
-0.0066081756,
-0.013899384,
0.0034615833,
-0.023024172,
0.009250783,
-0.00085959333,
-0.012427216,
0.00052097824,
0.01919123,
-0.002146911,
0.04896615,
-0.00029654728,
0.013660654,
-0.028249703,
-0.024854433,
-0.02177747,
0.019164704,
0.015384815,
0.014854304,
0.00909163,
-0.017016135,
0.010948418,
-0.013726968,
-0.010378119,
0.031273615,
-0.008163236,
0.012254801,
-0.0033770332,
-0.00064573117,
0.009409936,
-0.0077056703,
0.017957792,
-0.0009308808,
-0.018315887,
-0.00044927638,
-0.026485754,
-0.0014522735,
0.0046883896,
0.04307748,
0.04962929,
0.026976477,
0.004578972,
-0.014071801,
0.0062003457,
0.019655427,
-0.015477654,
-0.022135565,
0.01847504,
0.007871455,
-0.008826374,
0.0026691328,
-0.017055923,
-0.001274055,
0.014602311,
-0.015039982,
0.015079771,
0.0149073545,
0.023488367,
0.009675192,
0.0073807323,
0.01594185,
-0.023461843,
0.024695281,
0.0058157253,
0.026392914,
-0.0056167836,
0.018700507,
-0.014257479,
-0.011505454,
-0.029682081,
0.014801253,
-0.0003060799,
0.00660486,
-0.012142067,
0.021008229,
-0.017254865,
-0.01981458,
-0.017440544,
-0.0037832055,
-0.026286812,
-0.010583691,
0.0072348416,
-0.017440544,
-0.007486834,
0.005954984,
0.011604925,
0.009270677,
-0.006618123,
-0.043899775,
-0.0074006263,
0.005537207,
0.0136076035,
0.012029334,
-0.008587644,
-0.0136341285,
0.016671304,
-0.01608774,
-0.0021833838,
-0.024363711,
-0.033342607,
-0.019880895,
0.0016105978,
0.0020010206,
-0.0014746544,
0.0012823442,
-0.0017225024,
0.020517508,
-0.0060478235,
0.016910033,
-0.028727163,
0.0020474403,
-0.02641944,
0.025159476,
0.0059052487,
-0.00046502592,
-0.0013942488,
0.0006909075,
-0.030159542,
0.004532552,
-0.028196651,
-0.015039982,
0.001521903,
-0.012772049,
0.0015998217,
0.009602247,
-0.026817324,
-0.010590323,
-0.009104893,
-0.00524211,
-0.01913818,
0.027798768,
0.014801253,
0.008335652,
0.012128804,
-0.00035830206,
0.0022198563,
0.031220563,
0.00923752,
0.02555736,
-0.017772114,
-0.012692472,
0.01660499,
0.011982914,
-0.026764272,
-0.010835684,
0.00416451,
0.0052818987,
0.016021427,
-0.010583691,
-0.027719192,
-0.010610217,
-0.012599633,
0.0051857433,
-0.009363516,
-0.0077255643,
-0.0018186575,
-0.020411406,
0.0195228,
0.008415229,
-0.012400691,
0.038594663,
-0.040796284,
0.0032725888,
-0.0024900853,
0.009230888,
-0.0043104007,
-0.018899448,
-0.0048840153,
-0.010537271,
-0.010868841,
-0.0032543526,
-0.049045727,
-0.019933945,
-0.013501501,
0.00861417,
0.013713705,
0.034828037,
0.0026906847,
0.02364752,
0.017679274,
0.009874133,
-0.018634195,
0.01014602,
0.0057262015,
-0.0182761,
0.037905,
0.015703121,
0.003357139,
0.014774727,
-0.02297112,
0.02651228,
0.014191166,
0.0036737877,
0.0017009504,
0.004648601,
-0.023329215,
-0.0390456,
0.0042474023,
0.005822357,
-0.0091977315,
-0.017957792,
-0.006349552,
0.02240082,
0.0058057783,
-0.0025348472,
-0.017148763,
0.011803866,
-0.0040617236,
0.028992418,
-0.025013587,
0.021233696,
0.014124852,
-0.0027851819,
0.007294524,
0.0129776215,
0.015398078,
0.014297267,
0.010915261,
0.021127595,
0.0074934657,
-0.0053714225,
0.0019313911,
-0.02526558,
-0.016299946,
-0.0012143725,
-0.017215077,
-0.0177058,
-0.012864888,
-0.0047547035,
-0.035862535,
-0.002977492,
0.023620995,
-0.025756301,
0.01852809,
0.0025414785,
-0.0052321632,
0.031671498,
-0.01349487,
0.015411341,
-0.031565394,
0.018421989,
0.0148675665,
0.0054775244,
-0.01249353,
0.010159283,
0.025345156,
0.0023806675,
0.040716708,
0.005431105,
-0.019894157,
-0.021326536,
-0.007732196,
0.012281327,
-0.033581335,
-0.022798704,
0.019761529,
-0.002395588,
-0.022135565,
0.0065120207,
0.004827649,
-0.019575851,
-0.004002041,
-0.018740296,
-0.019761529,
0.012102279,
-0.008382072,
-0.025358418,
0.019880895,
-0.010000129,
0.00889932,
0.020000258,
-0.026777536,
-0.018249573,
0.006246765,
-0.0018518144,
0.03994747,
0.0014083405,
0.014045275,
-0.008401966,
0.0016213738,
0.013620866,
0.010510746,
0.0070027434,
0.00040845192,
-0.015729647,
0.043050956,
-0.00330243,
-0.006760698,
0.01990742,
0.014071801,
-0.012460373,
-0.0066678585,
-0.014960406,
-0.025186002,
-0.028010974,
0.01277868,
0.032440737,
0.009562458,
-0.02493401,
0.0076725134,
-0.020305302,
0.0049669077,
-0.0171355,
0.008647327,
-0.0020789395,
-0.049178354,
-0.031140987,
0.0012864888,
0.025424732,
0.018050632,
0.0023591155,
-0.0030205962,
-0.002622713,
0.019124916,
-0.0047679665,
0.040186197,
0.021353062,
0.004124722,
-0.02306396,
-0.002795129,
-0.033820067,
-0.033183455,
0.011671239,
-0.00588867,
-0.039682213,
-0.012122173,
-0.024682017,
0.023262901,
-0.015795961,
-0.0011240199,
0.027347835,
-0.0023176693,
0.020371616,
0.008746797,
0.016140793,
0.015809223,
-0.0136341285,
-0.015583756,
-0.00861417,
-0.021021493,
-0.0048342803,
0.0022928016,
-0.01986763,
-0.0016677935,
-0.01081579,
-0.016618252,
-0.00956909,
0.03488109,
-0.023010908,
-0.03183065,
-0.028249703,
0.004134669,
-0.025132952,
0.017918004,
-0.0019429959,
-0.027321309,
-0.0040186197,
0.018819872,
-0.010895367,
0.0071950536,
-0.022705864,
0.01876682,
-0.0098144505,
-0.034244474,
-0.005646625,
-0.000917618,
-0.035570752,
0.028965892,
0.016074479,
0.009502776,
-0.012765417,
0.0008670537,
-0.041565526,
-0.021048019,
-0.018581143,
-0.0074138893,
-0.0015185873,
-0.008083659,
0.014708414,
0.009065104,
-0.013660654,
0.013335717,
-0.011797235,
0.010185808,
0.01880661,
-0.010590323,
0.034828037,
0.027745718,
-0.017201815,
-0.012964359,
0.03474846,
-0.012075753,
0.0005591087,
0.020796025,
0.005252057,
0.011014732,
0.0042275083,
0.004011988,
0.013514764,
-0.00049611053,
0.02579609,
-0.058303144,
-0.013435187,
0.0021419376,
-0.004025251,
-0.00018039442,
0.010165914,
-0.014589048,
0.0035113187,
-0.0091513125,
0.0027868398,
-0.003335587,
0.023448579,
0.018355675,
0.009323728,
0.023050696,
0.0007294524,
0.006714278,
0.019416697,
0.018740296,
0.00029488944,
0.010583691,
-0.008382072,
-0.012526687,
-0.009025316,
0.020941915,
0.008508068,
-0.011160622,
0.007142002,
-0.024735069,
-0.006949692,
0.01120041,
-0.0046585486,
-0.0030703316,
0.027029527,
0.0070226374,
-0.006021298,
0.004761335,
-0.02153874,
-0.0330243,
-0.015291975,
-0.018103683,
-0.0037500486,
-0.004021935,
-0.023939302,
0.015729647,
0.0012110568,
0.005590258,
0.0065982286,
-0.04260002,
-0.0038495194,
0.017838428,
0.17910047,
0.0035875796,
-0.017334443,
0.013846333,
0.013547921,
0.00591188,
0.017016135,
0.005580311,
0.007241473,
0.013793282,
0.032467265,
0.01224817,
0.0077454583,
0.0006349552,
0.003713576,
-0.02130001,
-0.0091513125,
-0.0097879255,
0.001628834,
-0.027029527,
-0.00593509,
-0.032122433,
0.021750946,
0.013342348,
0.020981705,
-0.009157944,
-0.005752727,
0.011545243,
0.038064152,
0.010915261,
-0.009005422,
0.022281455,
-0.004197667,
-0.0069364295,
0.012626158,
-0.0010278648,
-0.009980235,
-0.026764272,
0.011492191,
0.0061671888,
-0.006226871,
-0.0010154309,
-0.021896835,
0.005507366,
-0.006949692,
0.0019164705,
0.0027238417,
-0.000016759792,
-0.020557296,
0.00024308173,
-0.044881217,
0.009708349,
0.004724862,
0.009396673,
0.004144616,
-0.0041379845,
0.0017142132,
0.023687309,
-0.010994838,
0.006402603,
0.0052487417,
-0.010490852,
-0.02933725,
0.005354844,
-0.021260222,
0.0042573498,
-0.008753429,
-0.01990742,
-0.008660589,
-0.023170061,
0.01904534,
-0.0043535046,
0.0046320227,
0.0012798575,
-0.004293822,
-0.015464392,
0.0037003132,
0.014071801,
0.007791878,
0.01832915,
-0.012566476,
-0.010059812,
-0.025623674,
-0.019827843,
-0.030637002,
-0.035491176,
0.023090485,
-0.0039025703,
-0.008667221,
-0.0136076035,
0.015809223,
-0.011664608,
-0.02249366,
0.011432509,
0.027878346,
0.0074337833,
-0.017599698,
0.0024486391,
-0.015013457,
-0.016498888,
-0.01876682,
0.071672015,
0.014204428,
0.003905886,
0.009648666,
-0.0035444757,
-0.033899643,
0.016618252,
-0.01120041,
-0.020040046,
-0.009051842,
-0.0129975155,
0.0021237012,
-0.015398078,
-0.012175224,
0.013150037,
0.016896771,
-0.012884783,
0.02761309,
-0.022719128,
-0.0060411924,
-0.022705864,
0.0019744951,
0.019708479,
0.0074404147,
0.0025182688,
-0.008275969,
0.011140727,
-0.015636807,
-0.03623389,
0.0059052487,
-0.009721612,
-0.010218965,
0.012566476,
0.0014116563,
0.011432509,
-0.0015028378,
-0.0033836644,
0.010517377,
0.019920683,
-0.0036837347,
-0.003421795,
0.022188617,
-0.0015633492,
0.026830586,
-0.016578464,
0.025663462,
0.016246894,
-0.021366324,
-0.016949821,
-0.014960406,
-0.00048409114,
0.0019148126,
-0.018846398,
0.025106426,
-0.0040318826,
-0.003866098,
-0.016551938,
-0.0117441835,
-0.013362242,
-0.001933049,
0.0034019009,
0.016896771,
-0.014589048,
0.012599633,
-0.014854304,
-0.1666865,
0.024827907,
0.018169997,
-0.03283862,
-0.008289232,
0.014947143,
0.015278713,
0.0023690625,
-0.012738892,
0.009297202,
0.0225865,
-0.002742078,
-0.006704331,
-0.023687309,
0.017639486,
0.006561756,
0.004671811,
0.021313274,
0.0079178745,
0.01187018,
0.039363906,
0.0055139973,
0.020132886,
-0.013886121,
0.005809094,
0.0059947725,
0.015000194,
0.006614807,
-0.010398013,
-0.014814516,
-0.020305302,
-0.0052089533,
-0.014589048,
0.0016661356,
-0.0077985097,
0.0012326088,
-0.01057706,
-0.008680483,
0.006090928,
0.026220499,
0.04021272,
0.036499146,
0.0011149017,
-0.006087612,
0.004559078,
0.04647275,
-0.013103618,
-0.022281455,
0.05116777,
-0.010039918,
0.022387559,
-0.0030355167,
0.025424732,
0.028568009,
0.0010154309,
0.028806739,
-0.017241603,
0.019496273,
-0.00025178542,
-0.016896771,
0.0031349875,
0.0073674694,
0.018979026,
0.0023243006,
-0.018819872,
-0.032759044,
-0.007374101,
0.0039556217,
-0.031432766,
0.008203024,
-0.022374295,
-0.017162027,
-0.0071685277,
0.006216924,
0.025941981,
0.011604925,
-0.017745588,
-0.0011364537,
-0.01014602,
0.019735003,
-0.009051842,
-0.0020540718,
-0.023674047,
-0.018965762,
-0.010497483,
0.04530563,
0.0018484987,
0.01746707,
-0.0005213927,
-0.006130716,
0.00571957,
-0.034138374,
0.010676531,
-0.0046320227,
0.012274695,
0.023620995,
-0.01392591,
-0.011260093,
-0.00442645,
0.001996047,
0.03885992,
0.00938341,
-0.018979026,
0.014443158,
0.007732196,
0.0034450048,
0.011266724,
-0.0036074738,
0.044165026,
-0.011279987,
-0.013567815,
-0.011591662,
0.024058668,
0.0065750186,
-0.005460946,
-0.0009690112,
0.017294655,
-0.011585031,
0.0059317746,
-0.030398272,
0.057401273,
0.02665817,
-0.0039489903,
0.0428918,
0.010132757,
-0.02412498,
-0.12116868,
-0.025159476,
-0.017055923,
0.03827636,
-0.00071328843,
0.01115399,
-0.020597083,
0.017347705,
0.00464197,
0.04273265,
-0.016313208,
-0.011989545,
0.012599633,
0.0036737877,
0.02355468,
0.0030305432,
0.00062832376,
-0.0020540718,
-0.04249392,
0.036631774,
-0.008063765,
-0.004157879,
-0.004220877,
-0.0078979805,
-0.0048840153,
0.0060080355,
-0.030239118,
0.013216351,
0.0079245055,
0.013952435,
0.011929863,
0.0149073545,
0.00732105,
-0.015902063,
-0.029602505,
-0.011989545,
0.014496209,
-0.024575915,
0.032705992,
-0.010338331,
0.0073873634,
0.018236311,
0.030849205,
-0.014973668,
0.0042076143,
0.0079245055,
-0.039310854,
-0.0006639675,
-0.0022911436,
-0.0012392402,
-0.011538611,
-0.01392591,
-0.009980235,
-0.0029194676,
0.021644842,
-0.025703251,
-0.0011671239,
0.01124683,
-0.014695151,
0.014045275,
-0.010079706,
-0.0011149017,
-0.017506858,
0.002977492,
0.017984318,
-0.012301221,
-0.0030819364,
-0.04843564,
0.01555723,
-0.028223177,
-0.005195691,
0.0050564315,
-0.019018814,
0.0043236637,
-0.008594275,
0.0017407387,
-0.011167253,
-0.0016321498,
-0.019774793,
-0.008362177,
-0.015159347,
-0.01153198,
0.024536127,
-0.024111718,
0.000027743023,
0.014628837,
0.017878216,
-0.00023935158,
0.007102214,
-0.028117076,
-0.010159283,
0.01445642,
-0.006379393,
-0.023130273,
0.009416567,
0.0142309535,
-0.0111009395,
-0.0017838427,
0.008070396,
0.00036161774,
-0.019416697,
-0.020504244,
-0.048753947,
0.007500097,
0.01919123,
-0.0048873313,
-0.016671304,
-0.02550431,
0.015384815,
-0.022626288,
0.002838233,
0.0015948482,
-0.02392604,
0.022573236,
-0.024920747,
-0.017559908,
-0.017838428,
0.01746707,
0.022506922,
-0.00057402934,
0.026804062,
0.023687309,
-0.02355468,
-0.015822487,
-0.0091513125,
0.012380797,
0.0056300466,
-0.003531213,
-0.0085478565,
0.024522863,
-0.027719192,
-0.0059748786,
0.007486834,
-0.051035143,
0.0033737174,
0.007652619,
-0.0031266983,
-0.0028316018,
-0.011896706,
0.02608787,
0.0110876765,
0.014257479,
0.0023806675,
-0.033422183,
0.008176498,
-0.0009399989,
-0.013886121,
-0.006883378,
-0.03111446,
-0.005417842,
-0.0039887787,
-0.020756237,
0.0046784426,
-0.003723523,
0.015663333,
-0.026061345,
-0.02832928,
0.010703056,
0.00016288341,
0.0055040503,
0.010955049,
-0.0231568,
0.021406112,
0.03713576,
0.021273484,
-0.01904534,
-0.00461876,
-0.012911308,
-0.010152651,
0.013978961,
0.003594211,
-0.051724806,
-0.031804126,
-0.016764143,
0.02177747,
0.017652748,
-0.028435381,
-0.0064722323,
-0.0022513554,
0.00029965575,
-0.008382072,
0.009555827,
0.020159412,
0.020066572,
-0.021419376,
0.027400885,
0.02454939,
0.0028995734,
-0.00909163,
0.04981497,
0.007891349,
0.02163158,
-0.027188681,
0.016591728,
0.009124787,
-0.003421795,
0.049470138,
0.019323858,
-0.00804387,
0.011333038,
0.010656637,
0.01493388,
-0.02603482,
0.0006618952,
0.0014705098,
-0.017108975,
-0.013216351,
0.008607538,
-0.027957922,
-0.023223113,
-0.010126126,
0.008581013,
0.018196521,
0.02187031,
0.011830392,
0.00708232,
0.0017357651,
0.01919123,
-0.009350253,
0.008587644,
0.008163236,
0.041618574,
0.0017059239,
0.018169997,
0.008077027,
0.0002791399,
0.009675192,
0.008401966,
0.024018878,
-0.016525414,
0.023846462,
-0.023183323,
0.004555762,
-0.006916535,
-0.024443287,
-0.0019827844,
0.0011704395,
-0.025729775,
-0.010338331,
0.036286943,
-0.023050696,
0.08811785,
0.002687369,
-0.0013801571,
-0.016963085,
-0.00509622,
0.03249379,
0.008130079,
0.006949692,
-0.010948418,
-0.021923361,
0.0064191814,
-0.023952564,
0.016671304,
-0.028010974,
-0.0136341285,
0.03392617,
0.013952435,
0.0056632035,
-0.006727541,
-0.014774727,
-0.021220434,
-0.016631516,
0.012752155,
0.044350706,
-0.006962955,
-0.017931268,
0.048037756,
-0.0030139647,
-0.014151377,
-0.032095905,
-0.0073475754,
0.0034251106,
-0.044775117,
-0.0008571066,
0.0061075063,
-0.0045822873,
0.0063860244,
-0.03756017,
-0.007732196,
0.0155439675,
-0.015159347,
-0.0047314935,
-0.02029204,
-0.029708607,
-0.01722834,
-0.012725629,
-0.01594185,
-0.0123144835,
0.004157879
] |
Advances in the fields of molecular and translational research, oncology, and surgery have emboldened the medical community to believe that intrinsic brain tumors may be treatable. Intraoperative imaging and brain mapping allow operations adjacent to eloquent cortex and more radical resection of tumors with increased confidence and safety. Despite these advances, the infiltrating edge of a neoplasm and distant microscopic satellite lesions will never be amendable to a surgical cure. Indeed, it is continued research into the delivery of an efficacious chemobiologic agent that will eventually allows us to manage this primary cause of treatment failure. | [
-0.019201642,
0.0052967705,
0.00456583,
-0.0012740467,
-0.008703294,
0.019908786,
-0.013524103,
-0.008655698,
-0.02280535,
0.008676097,
0.0062214956,
0.025416339,
0.0025361944,
0.024845185,
-0.0028098722,
0.005769332,
0.046209052,
-0.0047392156,
-0.030053563,
-0.005762533,
-0.038512077,
0.00089837715,
0.0051335837,
0.0026721833,
-0.0057183364,
0.014741205,
0.018589692,
-0.044196416,
-0.0057659326,
-0.008846083,
0.0039436803,
0.016386671,
-0.04166702,
-0.005844126,
-0.009940794,
-0.0015162771,
0.014251644,
-0.017433787,
-0.008410918,
-0.0061704996,
0.02121428,
-0.0036479041,
0.0068402453,
-0.015557138,
-0.026803426,
0.006857244,
0.000194103,
-0.023634883,
-0.00973681,
0.009526027,
0.019908786,
0.033806857,
-0.037560154,
0.0021197281,
-0.013864076,
-0.02896565,
-0.009213253,
0.02798653,
0.020996697,
-0.028285706,
-0.014564419,
-0.022043813,
-0.014156451,
0.026436256,
-0.01097431,
0.023240516,
-0.0075541874,
0.01714821,
0.0023526093,
-0.007567786,
0.035547517,
0.030787904,
-0.0077241734,
-0.015366754,
0.022587769,
-0.017583374,
-0.0221934,
-0.0021401264,
0.0050485907,
0.014115655,
-0.0006191748,
-0.025429938,
-0.023974856,
0.014115655,
0.038620867,
0.00950563,
-0.0073978,
-0.00578973,
-0.001553674,
0.0016131692,
0.016087495,
0.023961257,
-0.010083582,
0.0076289815,
-0.008669297,
0.029754387,
-0.008832484,
0.02107829,
0.019147247,
-0.026109882,
0.0079417555,
0.020316752,
-0.007119023,
-0.018725682,
-0.02083351,
0.022274993,
0.016726643,
-0.0014100356,
0.031848617,
-0.011640656,
-0.00009301433,
0.016128292,
0.00172706,
-0.0085469065,
0.031114276,
-0.0058611245,
0.03021675,
-0.010069983,
-0.012374996,
0.00027112802,
0.010715931,
-0.0048548062,
0.02183983,
-0.03304532,
0.0045590303,
0.0076901764,
-0.025620323,
-0.0075541874,
0.008560506,
-0.020398345,
0.0039028835,
0.017977742,
0.007982553,
0.013116136,
-0.0002687907,
-0.0046916194,
0.005215177,
0.0027180796,
-0.03095109,
-0.03541153,
0.01332012,
0.026694635,
-0.0070442287,
-0.011803843,
-0.010668335,
0.021608647,
0.020697521,
0.008642099,
0.040551912,
-0.012742166,
0.006051509,
-0.023811668,
-0.00013556401,
-0.02107829,
-0.0005894272,
-0.0018358511,
-0.007683377,
0.032773342,
-0.005585747,
-0.010341961,
0.0036037078,
-0.0033198309,
-0.00072159147,
0.026667437,
0.011198692,
0.02279175,
0.0039368807,
0.011926233,
-0.017324995,
-0.011035505,
0.0139524685,
0.040606305,
-0.02231579,
0.0007419898,
-0.02651785,
-0.00727541,
0.0067382534,
0.021975817,
-0.028992848,
-0.025375541,
-0.011892236,
0.0061433017,
0.001529026,
0.012021425,
-0.021295873,
0.0010921614,
0.03552032,
-0.013347317,
-0.0025973893,
-0.02749697,
0.006500273,
0.022914141,
-0.0071462207,
-0.0007568636,
-0.6405625,
-0.03473158,
0.02540274,
-0.028802464,
0.01565233,
0.022750955,
0.0019905386,
-0.015679529,
-0.012293403,
0.0035051156,
-0.009274448,
0.033398893,
-0.0008720293,
-0.007778569,
-0.0015842716,
-0.033126913,
-0.017474582,
-0.006983034,
0.009954393,
-0.012354598,
0.01739299,
0.013428911,
-0.02084711,
0.018222522,
0.009417236,
0.0039674784,
0.019446423,
-0.012918952,
-0.00690824,
0.015013183,
-0.011538664,
0.018535297,
-0.011035505,
-0.00579313,
0.046916194,
-0.009158857,
-0.019296834,
0.013490106,
0.019840792,
0.023621283,
0.0146596115,
-0.011824241,
0.02885686,
0.002084031,
-0.034568395,
0.024246834,
0.0110899005,
-0.023594087,
-0.011912634,
-0.013653292,
0.012096219,
0.008274929,
-0.02885686,
0.011293884,
0.006830046,
0.0007224414,
0.009566824,
-0.012347799,
0.011640656,
-0.010647937,
0.0058543254,
-0.0039164824,
-0.025960295,
-0.023648482,
-0.022342987,
0.028911255,
-0.046209052,
-0.0048548062,
0.006473075,
0.01540755,
0.022995735,
0.026558647,
0.0061840983,
-0.01319093,
0.023566889,
0.033834055,
0.0027571763,
0.0014958787,
-0.0028642677,
0.0028217712,
0.004246256,
-0.030271145,
-0.041095868,
0.014387633,
0.020520736,
-0.018140929,
-0.013870875,
0.006214696,
0.0089684725,
-0.009757209,
0.015257963,
0.021676643,
-0.018671285,
-0.042618945,
0.0022132206,
-0.011361878,
0.011273486,
0.0070850253,
0.028530486,
0.00094172364,
-0.0043958435,
-0.01332692,
0.01861689,
-0.0017848553,
0.015053979,
0.011042304,
-0.0050519905,
0.009451234,
0.03736977,
-0.03046153,
-0.003265435,
0.011572662,
-0.002896565,
-0.0031005486,
0.012055422,
-0.014700408,
-0.012531384,
-0.00023245615,
-0.015135572,
-0.021146284,
0.021880625,
-0.0027809744,
0.02294134,
-0.020602329,
0.029727189,
-0.01676744,
0.0099951895,
-0.008812086,
-0.0048378077,
0.0044706375,
-0.011314282,
-0.020425543,
0.003253536,
-0.015461946,
-0.0055109533,
0.0060855066,
0.001455082,
-0.015135572,
-0.02540274,
-0.022954939,
-0.020153565,
-0.010253568,
0.023240516,
0.041748613,
-0.016318677,
-0.019310433,
-0.020371148,
-0.0008274079,
-0.008791687,
-0.012871356,
-0.01344251,
0.008370121,
0.011416274,
0.027877739,
0.062446136,
-0.014401232,
-0.0017109113,
-0.022506176,
-0.0005337567,
-0.02022156,
-0.0034252221,
0.02315892,
-0.005289971,
0.005684339,
-0.0002836645,
-0.051757403,
-0.0026721833,
0.026164278,
-0.0013369416,
-0.03541153,
-0.0001966528,
-0.030869497,
-0.008553706,
-0.003146445,
-0.0010581642,
-0.0044196416,
-0.0033470285,
0.0003797067,
0.0076289815,
0.003600308,
-0.0061467015,
-0.0140204625,
0.014632413,
-0.013938869,
0.014034062,
0.018331314,
0.03505796,
-0.010069983,
0.0038688863,
-0.005463357,
-0.00055925467,
0.042346966,
-0.0069694347,
0.009512428,
0.008784887,
0.007860162,
0.007860162,
-0.0055347513,
0.0040796692,
0.018916067,
0.025674718,
-0.005126784,
0.017569775,
-0.0039776773,
0.026953014,
-0.025076367,
0.0055653485,
-0.013184131,
0.008485712,
-0.0028999648,
-0.013755284,
0.01380968,
-0.0073910006,
-0.019160846,
-0.008825684,
0.032365374,
0.005289971,
-0.026245872,
0.0059257196,
0.0056707403,
-0.0111035,
0.0011797043,
0.0011686552,
-0.005412361,
0.004130665,
0.030515926,
0.028421694,
-0.0036479041,
-0.0033504283,
-0.028285706,
-0.007887361,
0.03144065,
0.019582411,
0.0382129,
0.03182142,
0.011803843,
0.011858238,
0.00444004,
0.034323618,
-0.013653292,
0.012721769,
0.036390647,
-0.004514834,
0.0034099235,
-0.000327011,
0.02046634,
0.051104654,
0.010641137,
-0.005204978,
0.0019684404,
-0.027483372,
-0.007622182,
-0.0011193592,
-0.0010394657,
0.0020551332,
-0.024478015,
0.004229257,
0.014523623,
0.044930756,
0.026477052,
0.006027711,
-0.0036275059,
0.004229257,
-0.01418365,
0.00801655,
0.004106867,
0.027428975,
-0.009424035,
0.0028778666,
0.006500273,
-0.0115114665,
-0.027646558,
0.0047630137,
-0.039409604,
0.011191892,
0.010777126,
-0.00838372,
0.026490651,
0.0032739346,
0.02674903,
-0.0035221144,
-0.032990925,
0.02910164,
0.0061093047,
-0.004746015,
-0.000030172552,
-0.015516342,
0.006928638,
0.0013037942,
0.005816928,
0.026205074,
0.010552744,
-0.0068368455,
0.011416274,
-0.020439142,
-0.014278842,
-0.0024325028,
0.00050358416,
0.021173483,
-0.010899516,
0.007962154,
-0.0049839956,
-0.017800957,
0.010777126,
0.018004939,
0.00839052,
-0.011266686,
-0.0008558806,
-0.027469773,
-0.01901126,
0.002269316,
-0.023770873,
-0.014714006,
-0.014197249,
0.013877675,
0.0154347485,
-0.0037668946,
0.0012519484,
-0.00019112825,
-0.00004547131,
0.008519709,
-0.023050131,
0.0020755318,
0.0016352674,
0.040524714,
0.018181726,
-0.0011576061,
0.016536258,
0.03095109,
0.0044706375,
-0.008111742,
-0.021255076,
0.01947362,
-0.033344496,
-0.0024121043,
0.038702462,
0.021486258,
0.0160467,
0.015597935,
0.025321146,
-0.009172456,
-0.023349306,
-0.034568395,
-0.0036445044,
0.025865102,
-0.015203567,
0.016944226,
0.03622746,
0.01641387,
-0.017569775,
0.00064169796,
0.01837211,
-0.0037022997,
-0.0055177524,
-0.028340101,
0.014618814,
-0.00045683794,
0.020180764,
-0.008594503,
-0.032990925,
0.014074858,
-0.011994227,
0.0045012347,
-0.006187498,
0.01011078,
0.033072516,
0.025701916,
-0.0013275923,
-0.0009357741,
-0.029128838,
0.0049296003,
-0.00419186,
-0.01221181,
-0.009199654,
0.002021136,
0.0005159082,
-0.012517785,
-0.0184809,
0.01861689,
0.014346836,
0.0017899548,
-0.012293403,
-0.0019310433,
0.006262292,
0.01159306,
-0.029944772,
0.016944226,
-0.012408993,
-0.0016794638,
-0.01467321,
-0.0067552524,
0.0001650991,
-0.0084449155,
0.0016182688,
0.008920876,
-0.033861253,
-0.030271145,
0.0040252735,
0.020425543,
-0.006843645,
0.0144420285,
-0.014238046,
-0.0065444694,
0.017243402,
-0.0014499824,
-0.007139421,
-0.0076289815,
-0.024382822,
0.012001026,
0.00003152713,
-0.007683377,
-0.01910645,
-0.022370186,
0.0045284326,
0.01380968,
-0.013428911,
-0.0012383496,
0.025416339,
0.0026891818,
0.007928157,
0.010409956,
0.023036532,
-0.0001183529,
-0.01776016,
-0.012973348,
0.0018749479,
-0.039246418,
-0.01627788,
-0.004375445,
-0.013966068,
0.007384201,
-0.010423555,
-0.0035221144,
-0.010273967,
0.013496906,
-0.016903428,
0.016849034,
-0.005449758,
-0.0027265789,
0.006211296,
0.0052967705,
0.02775535,
0.0049296003,
0.013748485,
-0.0014134353,
0.013020944,
0.020017577,
-0.0076289815,
-0.014863594,
-0.0097096125,
0.008533308,
0.005871324,
-0.022302192,
-0.012918952,
0.0057659326,
0.03883845,
-0.0005401312,
-0.02775535,
-0.0147956,
-0.028992848,
0.0016165689,
-0.0005588297,
-0.020044774,
-0.007486193,
-0.006452677,
0.012782963,
-0.015937908,
-0.026409058,
0.009444434,
-0.029264826,
0.00444004,
0.03008076,
0.015217165,
0.012660573,
-0.009430835,
0.012055422,
-0.00666346,
-0.011062703,
-0.02687142,
-0.008118542,
-0.009233651,
-0.0060923058,
0.039246418,
0.027809745,
0.00197354,
-0.0017092114,
0.01528516,
0.019772796,
0.00752019,
0.015557138,
-0.0055381507,
0.020180764,
-0.0160467,
0.005721736,
-0.017270599,
-0.0010581642,
0.01467321,
-0.011157895,
0.0107363295,
0.024532411,
-0.007173418,
-0.01406126,
0.0043210494,
-0.038566474,
-0.034622792,
0.012463389,
-0.009118061,
0.004093268,
-0.021350268,
0.012422592,
0.019840792,
0.02702101,
0.0050043943,
0.005500754,
0.008608102,
0.020303153,
-0.02109189,
0.012177812,
-0.0015060778,
-0.008526509,
-0.0040388727,
-0.006595465,
-0.002245518,
0.012130217,
-0.008064146,
-0.0034082236,
0.0043380484,
-0.016917028,
-0.006187498,
0.011790244,
0.0059835147,
-0.0085469065,
-0.011321082,
-0.010926714,
-0.005602746,
0.0030529525,
-0.030107958,
-0.015067578,
0.0037770937,
0.011130697,
-0.004916001,
0.022642164,
-0.021363867,
-0.003403124,
0.031005485,
-0.008818884,
-0.0033096315,
-0.01529876,
0.032474168,
0.01899766,
0.015393952,
-0.004164662,
-0.01221181,
-0.020194363,
0.0075881844,
0.025511531,
0.0028897657,
0.017039418,
-0.00950563,
0.00727541,
0.017678566,
-0.00924725,
-0.03473158,
0.031359058,
0.0028676675,
-0.0030223548,
-0.023634883,
-0.03288213,
-0.032039,
0.042618945,
-0.020561533,
0.010552744,
-0.018181726,
-0.016359473,
-0.014115655,
0.024437219,
-0.0064050807,
0.031930212,
-0.012218609,
0.012157414,
-0.012259406,
0.0023407103,
-0.0063302866,
0.008342924,
0.01121909,
0.017719364,
-0.020765515,
0.00093917386,
0.0039912765,
0.010471151,
-0.0001609557,
-0.013673691,
0.0016420669,
0.046453834,
-0.011783444,
-0.0028829663,
0.0034371212,
-0.0081593385,
0.0070714266,
-0.004406043,
0.0015358254,
0.003241637,
-0.0072890087,
-0.004569229,
0.024573207,
0.023648482,
-0.017107412,
-0.010654736,
-0.02515796,
-0.016332276,
-0.01811373,
-0.012252606,
-0.002282915,
-0.02812252,
-0.0063914815,
0.013938869,
0.01258578,
0.014469227,
0.010566343,
-0.0024597005,
-0.0037260978,
0.032773342,
-0.030978289,
0.0057761315,
0.01699862,
0.0027520768,
-0.01455082,
-0.00050868373,
-0.007758171,
-0.029645596,
0.0008975272,
-0.02983598,
-0.021853428,
0.0028574683,
-0.010185574,
-0.0033929248,
0.0038042914,
-0.017651368,
-0.00007065052,
0.008635299,
0.026776228,
-0.023743674,
-0.051267844,
0.021146284,
-0.01824972,
0.008954873,
0.01578832,
-0.029536804,
-0.027306585,
-0.009165657,
0.0047936114,
0.012395395,
-0.0071462207,
-0.017053017,
-0.010525546,
0.015448347,
0.0072822096,
0.0079077585,
0.014292441,
-0.0029288626,
-0.019718401,
-0.005473556,
-0.00665666,
0.0017211104,
0.0036921005,
0.0015179769,
-0.018440105,
-0.0079077585,
-0.04843927,
0.010185574,
0.0010989609,
-0.029999167,
-0.034894772,
-0.00094172364,
-0.035193946,
0.028068123,
0.026191477,
0.0077717695,
-0.013530903,
-0.012544983,
-0.021404665,
0.00096382183,
0.024124444,
0.019650407,
0.023458097,
0.016386671,
-0.025552327,
0.025293948,
-0.019582411,
0.0072346134,
0.013102537,
0.0017474582,
0.014686809,
-0.0014984285,
0.00912486,
0.005993714,
-0.024314828,
-0.024083646,
0.012844158,
0.009410437,
0.016726643,
0.0028914656,
-0.017596973,
0.003428622,
0.0065444694,
-0.00059240195,
0.019351231,
0.025865102,
-0.006139902,
-0.017705765,
0.025334746,
0.010015587,
0.009566824,
0.0057251356,
-0.0081253415,
0.011776645,
0.023988454,
0.029183233,
-0.010403156,
-0.012313802,
0.009383239,
-0.01960961,
0.011701851,
0.022356587,
0.004453639,
0.018576093,
-0.014047661,
-0.0073978,
-0.027143398,
-0.025497932,
-0.03179422,
-0.017692165,
0.0012561982,
-0.026001092,
-0.0057149366,
0.000912826,
0.010226371,
-0.014849995,
-0.0015324258,
-0.0069592358,
-0.0060209115,
-0.015557138,
0.009104461,
0.0065410696,
-0.028394498,
-0.018902468,
0.017420188,
-0.031386256,
-0.010144778,
-0.029564003,
-0.0014661311,
-0.027347382,
0.019351231,
-0.012599378,
0.00038629366,
-0.0107703265,
0.011871837,
-0.010267167,
-0.022478977,
-0.0026619842,
0.1860329,
-0.006772251,
-0.023335708,
0.010076783,
-0.00345242,
0.013054941,
0.03059752,
0.004990795,
-0.0069592358,
-0.006051509,
0.016182687,
-0.0015740723,
-0.017977742,
-0.008866481,
0.02329491,
0.0029662594,
-0.018916067,
-0.019446423,
0.004746015,
-0.019908786,
-0.005585747,
0.001060714,
0.016427469,
-0.013374515,
0.0055551496,
0.0034728183,
-0.00296116,
0.026708234,
0.021907823,
-0.0076629785,
-0.01736579,
0.019024856,
-0.0009969692,
0.0036445044,
0.013503705,
-0.00071351713,
-0.014931589,
-0.0051403833,
-0.013211329,
-0.0038076912,
0.009947593,
0.011926233,
-0.0043346486,
0.0033861254,
0.0016174188,
0.027333783,
0.01887527,
-0.00029896325,
0.0121506145,
0.0042836526,
-0.043108504,
0.004249655,
0.029808782,
0.0076289815,
-0.012252606,
0.003294333,
0.012850958,
0.020207962,
0.0081593385,
0.004946599,
-0.02948241,
-0.017175406,
-0.017732961,
0.034867574,
-0.0023628084,
0.035928287,
-0.01158626,
0.0066056643,
0.027524168,
-0.000017543109,
0.018344913,
-0.024981175,
-0.02243818,
-0.0067314543,
0.013286122,
-0.02517156,
0.03304532,
-0.0066872574,
0.016917028,
0.009553225,
-0.0011814042,
-0.0008248581,
0.012565381,
0.008975272,
-0.014292441,
-0.029264826,
0.029183233,
0.010416755,
0.011198692,
-0.017311396,
-0.016169088,
0.0055925464,
-0.001011418,
-0.009933994,
0.018086534,
0.006425479,
0.021119088,
0.020683922,
-0.027415376,
0.00802335,
-0.019419225,
0.0628813,
0.021799032,
-0.00542256,
0.008410918,
0.02121428,
0.0041102665,
0.009226852,
0.013966068,
-0.0010046185,
0.018807275,
-0.023852466,
0.0019089452,
-0.013102537,
0.0038382888,
0.04131345,
-0.015230765,
-0.023512494,
0.012510985,
-0.012143815,
0.0055041537,
-0.03318131,
-0.0014227846,
0.03141345,
-0.031767022,
-0.009294846,
-0.035656307,
0.003341929,
0.005388563,
-0.029808782,
-0.011729049,
-0.021105489,
-0.009118061,
0.0019684404,
0.009879598,
-0.0077241734,
0.011280285,
0.0050587896,
-0.016345873,
0.008098143,
-0.010049585,
-0.004327849,
-0.006187498,
0.027904937,
0.011008307,
-0.023811668,
-0.0013003945,
0.014319639,
-0.0044434397,
-0.019147247,
-0.012055422,
-0.03288213,
0.0054021617,
0.0013275923,
0.009233651,
-0.023526091,
-0.017610572,
-0.018086534,
-0.010579942,
0.030488728,
-0.046290647,
0.0051233843,
0.01652266,
-0.042346966,
-0.005238975,
0.00875089,
-0.17199884,
0.0076629785,
0.008145739,
-0.02046634,
0.028992848,
0.012633376,
0.0072618113,
-0.017202605,
-0.006707656,
-0.0017347094,
-0.0017695564,
0.02332211,
-0.055320315,
-0.018208923,
0.003896084,
0.008907278,
0.011117099,
0.035193946,
0.009933994,
0.012021425,
-0.018412907,
-0.02540274,
0.025715515,
-0.021159884,
-0.0012663973,
0.0029322621,
-0.014985984,
-0.003243337,
0.0049805962,
-0.009158857,
-0.011667854,
-0.026925817,
0.023893261,
-0.024002053,
0.028176915,
0.0011890535,
-0.0032722347,
-0.010083582,
-0.033834055,
0.0009706213,
0.0033147312,
0.041286252,
0.016291479,
0.009573624,
-0.029237628,
0.0010173675,
0.024192438,
-0.015461946,
0.019623209,
0.010158376,
0.017542576,
-0.0043414477,
-0.026993811,
0.018290516,
0.030842299,
0.009158857,
0.0039164824,
0.005895122,
0.011232689,
-0.015992302,
-0.024396421,
-0.019188045,
0.009090863,
0.014972386,
-0.033589277,
-0.03511235,
0.016386671,
-0.0047698133,
-0.009226852,
0.014972386,
-0.030271145,
0.029074442,
0.018766478,
-0.023145324,
-0.006877642,
0.0005953767,
-0.0024495013,
0.0021554253,
-0.011416274,
0.002553193,
-0.008234132,
0.012830559,
-0.016577056,
-0.016808236,
0.0013369416,
-0.002084031,
0.027959332,
0.0058271275,
0.015121974,
0.0008070096,
0.004994195,
-0.024165241,
0.009723212,
-0.023825267,
0.010076783,
0.042700537,
0.01368729,
0.005857725,
0.009356041,
-0.0121166175,
0.019582411,
-0.012510985,
-0.015067578,
0.0027911735,
0.031168671,
0.0025667918,
-0.0033759263,
0.0038042914,
0.026830625,
0.017107412,
-0.023009334,
-0.0016463165,
0.010409956,
0.00135649,
-0.019772796,
0.02872087,
0.0017296097,
-0.0067586517,
0.013401713,
-0.022410983,
0.05711537,
-0.01591071,
-0.0051369835,
0.0032569359,
-0.00076111325,
-0.011742648,
-0.14708567,
-0.038158506,
0.005126784,
0.0065410696,
-0.015135572,
0.0058033294,
-0.008002951,
0.0067144553,
-0.0456379,
0.0406607,
-0.03772334,
-0.019813593,
0.0039164824,
-0.012769365,
-0.000690569,
0.0007793868,
0.0039164824,
0.005871324,
-0.017189005,
0.022492576,
0.0100291865,
0.00096977135,
0.011137497,
-0.019215241,
-0.005657141,
0.017257001,
-0.027265789,
0.0039708777,
0.01714821,
0.0035697105,
0.02329491,
-0.017964143,
0.021717438,
0.0033368294,
0.015693128,
0.012103018,
-0.0009833702,
-0.021105489,
0.019568812,
-0.03288213,
-0.0006880192,
0.00813214,
0.013877675,
0.018576093,
-0.00382129,
-0.02575631,
-0.039899163,
-0.0012001026,
0.013517303,
-0.020615928,
-0.016114693,
-0.04218378,
-0.025280349,
0.00013142059,
0.021975817,
-0.010491549,
0.0072686104,
0.006847045,
-0.00641188,
-0.022846147,
-0.017624171,
-0.016386671,
-0.029020047,
0.013938869,
0.023594087,
-0.00060260115,
-0.02441002,
-0.036689825,
-0.0012162514,
-0.0024070048,
-0.0019412426,
0.017964143,
-0.02983598,
-0.002971359,
-0.037587352,
-0.0067654513,
0.006547869,
-0.02330851,
0.027156997,
-0.011912634,
-0.00026156628,
-0.01788255,
0.02379807,
-0.015937908,
0.030923892,
0.011531865,
-0.003933481,
-0.0121506145,
0.03288213,
-0.0154347485,
0.023716476,
0.02009917,
-0.010872318,
-0.02205741,
0.015829116,
0.006867443,
-0.018426506,
-0.01627788,
0.022954939,
0.017868951,
-0.023526091,
-0.01455082,
-0.03761455,
0.011627057,
-0.002070432,
-0.0047698133,
0.0007143671,
-0.0038654865,
0.028911255,
0.00011782169,
0.02083351,
0.023702879,
-0.013272524,
0.027360981,
-0.004083069,
0.010369159,
-0.025824307,
-0.023444498,
0.011810642,
-0.02330851,
-0.0022030214,
0.017093813,
0.018956862,
0.0029866577,
0.022669362,
0.016726643,
-0.011402675,
0.013891273,
0.0038518875,
0.038131308,
-0.0160467,
-0.019691203,
-0.010171975,
-0.021227878,
-0.004083069,
0.0070578274,
-0.004780012,
-0.024450816,
0.01824972,
0.01627788,
0.016617853,
0.07310767,
-0.028829662,
-0.034350812,
0.0068334457,
0.0058237277,
-0.0029033646,
0.0075065913,
-0.023934059,
0.006870843,
-0.010593541,
-0.009118061,
0.02133667,
0.009016069,
-0.018059336,
-0.030026365,
-0.015693128,
-0.00038459382,
0.006211296,
-0.004171462,
-0.020575132,
-0.019310433,
0.03141345,
0.028476091,
-0.029210432,
0.011001508,
0.010001989,
0.0025089965,
-0.0209559,
0.005099586,
0.0019293436,
-0.020044774,
-0.029074442,
0.0009451234,
0.0073434045,
0.0014227846,
0.0062010973,
-0.031603836,
-0.0135649,
-0.0012154015,
0.014333238,
0.027306585,
0.008295327,
-0.011280285,
-0.007860162,
0.018181726,
0.005266173,
0.0023730076,
-0.0071598194,
0.027320184,
-0.025266752,
-0.010205972,
0.008859682,
0.013102537,
0.010654736,
0.029618397,
-0.01947362,
0.0019446423,
-0.016713044,
0.009743609,
0.027089003,
0.021649444,
0.013755284,
-0.015162771,
0.0060345107,
-0.0058645243,
-0.020928703,
0.023648482,
-0.036445044,
0.002774175,
-0.016101094,
0.043570865,
0.022628564,
0.011361878,
0.021731038,
-0.0019565413,
-0.019147247,
0.006500273,
-0.01072953,
-0.020248758,
-0.0073638028,
0.02011277,
0.024899581,
0.0041544633,
0.018712083,
-0.0035595114,
0.004426441,
-0.0037294975,
0.00080828444,
-0.026694635,
0.0037940922,
0.014129254,
0.024165241,
-0.0041612624,
-0.036771417,
0.016794639,
6.972091e-7,
-0.032338176,
0.024627604,
-0.0023339107,
0.0020993298,
0.06483954,
-0.0068334457,
-0.010947112,
0.023036532,
-0.040987074,
0.006989833,
-0.00703063,
0.011321082,
-0.032229386,
-0.027646558,
0.023566889,
-0.01824972,
0.023349306,
-0.029400816,
-0.035085153,
0.03440521,
-0.016087495,
0.028068123,
-0.011599859,
-0.010185574,
0.020806313,
-0.0015511242,
0.00080615963,
0.021105489,
-0.040007956,
0.025742711,
0.0040150746,
-0.0069762343,
-0.0023526093,
-0.050261524,
0.014877194,
-0.005388563,
-0.052083775,
-0.020316752,
0.0024240033,
0.00012493986,
-0.004365246,
-0.028204113,
-0.009009269,
0.025307547,
0.009376439,
0.021418262,
-0.01319093,
-0.019446423,
-0.021146284,
-0.006496873,
-0.0041034673,
-0.016930627,
-0.010987909
] |
BACKGROUND Organophosphorus pesticide (OP) self-poisoning is a major problem in the developing rural world. There is little clinical trial data to guide therapy, hindering the identification of best therapy. Despite the recognition of adverse effects, gastric lavage is commonly done in Asia. We aimed to identify studies assessing its effectiveness. METHOD We systematically searched the literature for controlled clinical studies that assessed the effect of gastric lavage in OP pesticide self-poisoning. RESULTS All 56 studies identified were Chinese and reported benefit from the intervention studied, including multiple gastric lavages, use of norepinephrine or pralidoxime in | [
0.0018114093,
0.02906473,
0.033173785,
-0.017312827,
-0.020463103,
0.037145875,
-0.012039537,
-0.009985008,
-0.017614158,
-0.012717531,
-0.0010503777,
0.018312696,
-0.029092124,
0.022038242,
-0.0067593986,
0.013895461,
0.035666615,
-0.014546062,
-0.007814056,
0.01045755,
-0.006529976,
0.019572807,
0.0012224445,
0.0016590317,
0.009217984,
0.00040897957,
0.0070881234,
-0.030927502,
-0.0015057982,
0.008834473,
-0.0077592693,
-0.021832788,
0.0019004388,
-0.0045815986,
0.0014895331,
-0.031831495,
0.011299906,
0.0054034097,
-0.0071566077,
0.011293058,
0.013450313,
0.009813798,
0.02113425,
0.016874528,
-0.024147557,
-0.00016693043,
-0.013484555,
-0.026421236,
-0.025859665,
0.025147429,
0.018066153,
0.0061019496,
0.009300166,
0.0033009425,
0.02361338,
-0.008170174,
0.024941975,
0.013655766,
0.008704352,
-0.056266688,
0.014025581,
0.0025322062,
-0.03385863,
0.0069785486,
-0.0069374577,
0.010573973,
-0.005677347,
0.005098655,
0.013559888,
-0.005146594,
0.03429693,
0.04330946,
-0.01276547,
-0.008827624,
0.041802805,
-0.0094508305,
-0.025626818,
-0.016614286,
0.017723732,
0.019230386,
0.031311013,
-0.02261351,
-0.0018661967,
0.012580562,
0.01855924,
0.009526163,
0.002174376,
0.007081275,
0.0025544637,
-0.0063690385,
-0.009560406,
0.040159184,
0.028489461,
0.007937328,
-0.002444889,
0.026503418,
-0.009676829,
0.035091348,
-0.017860701,
-0.0344065,
-0.027119776,
-0.0142858215,
-0.018572938,
-0.010121977,
-0.01855924,
0.0063279476,
0.01385437,
-0.023147687,
0.024914581,
0.00056028704,
-0.016573196,
0.025257003,
0.0023387382,
0.0016847133,
-0.009553557,
-0.012642198,
0.007389454,
-0.008868715,
-0.027955284,
-0.033146393,
0.013799583,
0.014231034,
0.02958521,
-0.012539472,
0.02479131,
-0.01490218,
-0.01969608,
-0.004608992,
0.0081153875,
0.0021213007,
0.010663003,
0.05144539,
0.020093288,
-0.007649694,
-0.01929887,
0.029557817,
-0.01903863,
-0.021709517,
-0.02892776,
-0.023421625,
0.022120424,
0.009156348,
-0.004081663,
-0.023859924,
0.00020127959,
0.008368779,
0.02043571,
0.0392278,
-0.022668298,
0.0027427955,
-0.009546709,
-0.018901661,
0.006810762,
0.011916265,
0.0013705418,
-0.009731617,
0.008793382,
0.02906473,
-0.003961816,
-0.017148465,
-0.013498252,
-0.021202734,
-0.014135156,
-0.0073004244,
-0.0020562406,
0.015710294,
0.014018733,
0.009553557,
0.0023250415,
-0.009642587,
0.009752162,
0.032954637,
-0.028078556,
0.0077318754,
-0.022024546,
0.0035954248,
0.026393842,
0.016175987,
0.008272901,
0.00037965973,
-0.03489959,
0.028215524,
0.005982102,
0.010039796,
0.0020973312,
0.0075949067,
-0.0037940294,
-0.019846745,
-0.0072045466,
-0.0274485,
-0.0038796347,
0.02205194,
0.0051705632,
-0.0019740595,
-0.6285213,
-0.02479131,
-0.0037666354,
-0.009622042,
0.020750737,
0.0063279476,
0.022229997,
-0.0133886775,
0.0025082368,
0.022216301,
-0.0045952955,
0.020709647,
0.006509431,
-0.012121718,
0.0035440617,
-0.021038372,
0.02025765,
-0.008122236,
0.03977567,
-0.013327042,
-0.010416459,
-0.0015366161,
-0.02605142,
0.023339443,
0.024996763,
0.01720325,
0.033091605,
-0.02035353,
-0.0009673405,
0.0116423275,
0.00867011,
0.023421625,
-0.010389065,
0.01219705,
0.048733417,
-0.032215007,
-0.0075195744,
0.0035714554,
0.008204417,
0.038625136,
-0.00307152,
-0.004338479,
0.027051292,
-0.005581469,
-0.025709,
-0.013142134,
0.03665279,
0.0023233292,
-0.0055403784,
-0.0062457668,
0.015847264,
0.008368779,
0.0074784835,
0.02235327,
0.025120035,
0.014107762,
-0.0024911158,
-0.033310756,
-0.016751256,
0.004715143,
-0.01903863,
-0.0036022733,
-0.019791957,
-0.00061635853,
-0.034242142,
0.019915229,
-0.0344065,
0.010416459,
-0.017792217,
0.0054342276,
0.0037666354,
0.016696468,
0.015285692,
-0.003937846,
0.011128696,
0.026585598,
-0.0021658153,
0.031968463,
-0.020230258,
-0.009827495,
-0.010430156,
0.011868326,
0.002383253,
0.0103411265,
0.04906214,
-0.008081146,
-0.03002351,
0.012149111,
0.02035353,
-0.01847706,
0.0067080352,
0.027078684,
0.00092025753,
0.001647903,
-0.03002351,
0.0169978,
-0.009081016,
-0.015915748,
0.022640904,
-0.028516855,
-0.03246155,
-0.017162161,
-0.005471894,
0.008745443,
0.008464658,
0.012361413,
-0.017764824,
0.008067449,
0.038351197,
-0.0015725703,
0.013690008,
-0.0034618804,
-0.0014441623,
-0.00010144234,
0.029311273,
-0.022339573,
-0.01416255,
-0.0020219984,
-0.036461033,
-0.047007613,
-0.0009964464,
-0.013224315,
0.0120669305,
0.00014456605,
0.0029396878,
0.0036570607,
-0.005180836,
-0.024120165,
0.015710294,
-0.004112481,
-0.0017942882,
-0.013443464,
0.006303978,
-0.014381699,
0.018572938,
0.000048527534,
0.016175987,
-0.004413812,
0.023175081,
-0.007786663,
-0.026366448,
-0.019627595,
0.012601108,
0.01150536,
-0.007909935,
-0.026339054,
-0.007855147,
0.012450443,
-0.030489203,
0.022599813,
0.022627207,
-0.023079203,
-0.005307532,
0.023764046,
0.004872657,
0.014751514,
0.0060300413,
-0.031831495,
-0.038679924,
0.009882282,
0.022106726,
-0.0024209195,
-0.0071634557,
0.00027885943,
-0.02980436,
-0.034488685,
0.021271218,
0.0073963027,
-0.010389065,
-0.034242142,
0.024914581,
-0.029694784,
0.00823181,
0.0019603625,
-0.02025765,
0.015080239,
-0.017723732,
-0.02301072,
-0.012696986,
0.0026760234,
0.021627337,
-0.00064246816,
-0.0024260557,
0.018107245,
0.013012013,
-0.005310956,
0.018394878,
0.031064471,
-0.008224962,
0.034981772,
0.010176765,
0.012806561,
-0.006619006,
-0.0008068305,
-0.014148853,
0.0017163873,
0.018162033,
0.01416255,
-0.015436357,
0.022955932,
0.03698151,
-0.020641163,
0.012909288,
-0.017436098,
0.031064471,
-0.008430415,
-0.0036228185,
-0.019490628,
0.021641033,
0.025257003,
-0.0035098195,
-0.013765341,
-0.0081290845,
-0.017997669,
-0.018216819,
0.017504582,
0.0062800087,
-0.015176117,
-0.0025304942,
0.0021178764,
0.01734022,
-0.014231034,
0.022928538,
0.015833566,
-0.011799842,
0.009252227,
0.004307661,
0.020983584,
-0.013101043,
0.0005376016,
-0.010923243,
0.020791829,
0.0052972594,
0.014710424,
0.02165473,
0.019230386,
0.00043530323,
-0.006762823,
0.02696911,
0.0033523056,
-0.03577619,
0.014737817,
0.027599165,
0.0012138839,
0.014628243,
0.006701187,
0.040241364,
-0.020422013,
-0.02470913,
0.027571771,
0.014217337,
0.00927962,
-0.020490497,
-0.0024226315,
-0.0077798143,
-0.014915877,
-0.0024928278,
0.0049479892,
0.024681736,
0.024503676,
0.0013765341,
-0.019942623,
-0.0015460327,
-0.009841192,
0.0015605856,
-0.019353658,
-0.00832084,
0.023298353,
-0.011060212,
-0.014833695,
-0.013066801,
-0.029996116,
0.035885762,
-0.019805655,
0.023243565,
-0.0039138766,
-0.014436487,
0.0041946624,
0.0056259837,
0.0026897201,
-0.037529387,
-0.011375239,
0.011594389,
0.019381052,
0.006571067,
0.006988821,
-0.032625914,
0.0011060211,
-0.009272772,
0.008601625,
0.008170174,
0.00953986,
-0.005081534,
0.013053104,
0.00498908,
-0.03210543,
0.0012994893,
0.00030668118,
-0.00092196965,
0.008348234,
-0.011313603,
0.0032427309,
-0.0138269765,
0.008724897,
0.009902827,
0.015970534,
-0.011210877,
-0.029639997,
0.013696857,
-0.004591871,
0.014792605,
0.0048521115,
0.015943142,
-0.0015366161,
-0.013737947,
0.014751514,
-0.02357229,
0.02169582,
0.03873471,
-0.0059238905,
-0.0010135673,
-0.014080368,
0.0010914683,
0.014313215,
0.033612087,
0.0059889504,
0.00068826706,
0.033064213,
0.014477577,
-0.02231218,
-0.0074921804,
-0.033009425,
0.022106726,
0.0069477307,
0.01237511,
0.04013179,
0.012108021,
0.013196921,
0.039583914,
0.007307273,
-0.010635609,
-0.027311532,
-0.0033368967,
0.0015477447,
0.0044549024,
-0.008697504,
0.008094843,
0.021819092,
0.0040885117,
0.009396044,
0.012354565,
0.02435301,
0.01869621,
0.006139616,
-0.022366967,
-0.014765211,
0.019874139,
0.013018862,
-0.010354823,
-0.0039549675,
0.012292929,
0.015888354,
0.028516855,
-0.0019398173,
0.010663003,
0.001472412,
-0.01681974,
0.0066772173,
0.011210877,
0.0029824905,
0.009834343,
0.043638185,
-0.030297447,
0.00409536,
0.011854629,
0.0030646715,
0.003646788,
-0.02622948,
0.01250523,
-0.0169978,
0.0053178044,
-0.0023113445,
-0.010902698,
-0.0035269405,
0.0084989,
-0.027270442,
-0.0048966263,
-0.013587282,
-0.018942753,
-0.017764824,
-0.028352493,
-0.022668298,
-0.018216819,
-0.00088087906,
0.0072524855,
-0.03594055,
-0.007423696,
0.0045679016,
0.030927502,
-0.0063108266,
0.029475635,
-0.025818575,
-0.0151487235,
0.01847706,
0.002319905,
-0.020586375,
-0.00018201838,
-0.022503935,
0.019148204,
0.035748795,
0.011121848,
-0.00082223944,
-0.031174045,
0.0015725703,
0.016806044,
-0.019024933,
0.011060212,
0.020654859,
0.0027753254,
0.00086889433,
0.01381328,
0.027653953,
0.009135803,
-0.0067765196,
0.0023644199,
-0.0063587655,
-0.023805136,
-0.01855924,
0.00732097,
-0.003451608,
-0.0036707576,
-0.0010966046,
0.0030475506,
0.022243695,
0.03372166,
0.0008183872,
-0.007663391,
-0.00867011,
0.017093677,
0.052048054,
-0.012176505,
0.03333815,
-0.014066672,
-0.0069477307,
-0.018011367,
0.0062594633,
0.0062081004,
0.0031382923,
-0.01855924,
0.01202584,
0.014080368,
-0.032790273,
-0.018299,
-0.019093418,
0.018244212,
0.022545027,
-0.008902957,
-0.014313215,
-0.020422013,
0.009902827,
-0.026544508,
0.016244471,
-0.007725027,
-0.04484351,
0.0030989137,
-0.0008894396,
-0.002258269,
0.0029705057,
0.060101807,
-0.025996633,
-0.005129473,
0.0010632185,
-0.018805783,
0.01494327,
-0.003920725,
-0.0056533776,
-0.0031074744,
0.010231552,
-0.037282843,
-0.016354047,
-0.03446129,
-0.010032947,
0.02113425,
0.0011873463,
0.027338926,
-0.018367484,
0.004191238,
0.014354305,
-0.0072045466,
0.011477966,
-0.02435301,
-0.0066600963,
-0.02343532,
0.023449019,
0.004222056,
-0.026722567,
-0.011614935,
-0.026599295,
0.005725286,
0.021942364,
-0.016532106,
-0.023818834,
-0.014354305,
-0.015299388,
-0.024339315,
0.0055095605,
-0.010875304,
0.011854629,
-0.0070470325,
-0.008211265,
0.020641163,
0.009252227,
-0.008444112,
-0.028160736,
-0.001135983,
-0.025202217,
-0.01442279,
0.008546839,
-0.00023413064,
-0.02227109,
-0.02117534,
-0.023175081,
-0.0046637794,
-0.016326653,
0.005992375,
-0.010642458,
-0.0023558594,
-0.0165595,
-0.034050386,
0.02269569,
0.008875563,
-0.0019329689,
-0.024887187,
-0.020449407,
-0.0129846195,
-0.0013491403,
0.007944177,
-0.023298353,
0.014614546,
0.009991857,
0.004461751,
0.022627207,
-0.051226243,
-0.01734022,
0.002622948,
-0.019271476,
0.012909288,
-0.02435301,
0.03473523,
0.021339701,
-0.005050716,
-0.010005553,
0.011080757,
-0.0035920006,
0.00039892094,
0.009786404,
0.006430674,
-0.020161772,
-0.027722437,
-0.0047219913,
0.009943917,
-0.019682383,
-0.018929055,
0.027078684,
-0.0035783038,
-0.009567254,
-0.027462197,
-0.012820258,
-0.046733674,
0.048075967,
0.0071771527,
0.010238401,
0.0012421337,
0.009991857,
-0.012751773,
0.017477188,
-0.01311474,
0.007259334,
-0.0085810805,
0.0024705704,
0.0058143158,
-0.031694528,
-0.02662669,
0.015450054,
-0.023722956,
0.018230516,
0.005102079,
-0.0013534207,
-0.025654212,
0.036899332,
0.022120424,
-0.004146723,
0.0040679662,
0.03961131,
0.008081146,
0.005564348,
0.009101561,
-0.0028386735,
0.015559629,
-0.029201698,
-0.015080239,
-0.02383253,
0.0045062657,
0.0019107115,
0.0056704986,
0.009327559,
-0.038049866,
0.0010572261,
-0.025695303,
-0.014956967,
0.0043932665,
-0.026256874,
0.0053486223,
-0.025585728,
-0.0022788146,
0.0026777354,
-0.01899754,
-0.00069126324,
0.009471376,
-0.01734022,
0.004992504,
0.0035543342,
-0.011786145,
-0.014669334,
0.011293058,
-0.0009930221,
-0.01638144,
0.029749572,
-0.009320711,
-0.023216171,
0.026256874,
0.0007661679,
-0.043062918,
-0.024681736,
-0.019271476,
0.0059444355,
0.009676829,
-0.0008462089,
0.023462715,
-0.006738853,
0.020326136,
-0.008341386,
0.00052390475,
0.0200385,
-0.03851556,
0.00015301957,
0.030872714,
-0.018394878,
-0.0072661825,
-0.023325747,
-0.00082437956,
0.0056396807,
-0.006666945,
-0.0046124165,
-0.025626818,
0.021421883,
-0.014833695,
-0.029092124,
-0.019778261,
0.007149759,
-0.01851815,
0.001965499,
-0.011854629,
-0.0021880728,
-0.008779685,
-0.021367095,
0.014121459,
-0.021189038,
-0.02121643,
0.011847781,
-0.014998058,
-0.030133083,
-0.012320322,
-0.019189296,
-0.014984361,
0.027256744,
-0.0053657433,
-0.016518408,
-0.007964722,
-0.0036570607,
-0.029776966,
0.03002351,
-0.017093677,
0.0027445075,
0.0061053736,
0.007916783,
-0.0015614417,
-0.018175729,
0.00623207,
-0.0008042623,
-0.0035440617,
-0.010704094,
-0.0035714554,
-0.020874009,
0.025078945,
-0.009211136,
-0.021997152,
-0.021065766,
-0.0022497086,
-0.009786404,
-0.0029122941,
-0.009046773,
0.024462586,
-0.0073483633,
-0.03695412,
-0.0020733615,
0.004287116,
-0.006680642,
-0.004317934,
-0.015915748,
-0.01803876,
0.011916265,
0.00457475,
-0.02213412,
-0.010142522,
0.024503676,
-0.017531976,
0.008813927,
-0.023421625,
-0.03098229,
0.003389972,
-0.012676441,
0.012601108,
0.0023729804,
-0.0009057046,
0.009580951,
-0.004910323,
0.004348752,
-0.038104653,
-0.0129572265,
-0.014135156,
0.004619265,
0.015080239,
-0.010553428,
0.0028729157,
-0.01001925,
0.020668557,
-0.013162679,
0.010238401,
-0.0060745557,
0.008094843,
-0.00037495146,
0.029311273,
0.018490756,
0.0044172364,
-0.010635609,
0.0064067044,
-0.011697115,
-0.0058451337,
-0.038323805,
-0.00793048,
-0.035091348,
-0.010635609,
-0.026202086,
-0.004787051,
0.013710554,
0.00018373049,
-0.017244343,
-0.029530423,
0.017655248,
0.18036021,
-0.0063108266,
0.00023926696,
0.020805525,
-0.007546968,
0.017655248,
-0.000013375837,
0.010519186,
-0.02379144,
-0.000099034696,
0.032872457,
-0.034926984,
-0.01951802,
0.007642846,
0.005197957,
-0.0066703693,
-0.0322424,
-0.0124915335,
0.0023712683,
0.0120669305,
0.015970534,
-0.008608474,
0.005071261,
0.022572419,
0.030352235,
0.0009570678,
-0.007067578,
0.00026623264,
0.012566865,
0.00051149196,
0.007094972,
0.016792346,
0.026503418,
0.014080368,
0.021887576,
0.0058108913,
-0.0032324581,
-0.02017547,
0.011060212,
0.015093936,
0.013128437,
0.0031400044,
-0.00962889,
0.0006638695,
-0.027859407,
0.019134508,
0.01490218,
-0.009033076,
-0.005167139,
0.011368391,
-0.031201439,
0.006721732,
0.03607752,
0.012916136,
-0.0052732895,
0.000639044,
0.018463362,
-0.0065025827,
-0.009067319,
0.026078815,
0.004783627,
0.02448998,
0.0005132041,
0.01324486,
-0.009738465,
0.020271348,
0.0044651753,
-0.027270442,
-0.0014535789,
-0.025298094,
0.014011884,
0.00409536,
0.0062081004,
-0.00093481044,
-0.020558981,
-0.023449019,
-0.0142721245,
0.03930998,
0.0015854111,
0.019024933,
-0.028544249,
-0.0074784835,
-0.022668298,
-0.003359154,
-0.02622948,
-0.0005084958,
0.016751256,
0.018750997,
-0.02980436,
-0.0043145097,
-0.020558981,
-0.0045987195,
-0.031447984,
0.008053752,
0.007040184,
-0.023298353,
0.015545932,
0.008375628,
-0.020476801,
-0.008040055,
-0.016586892,
0.06256724,
-0.0156007195,
0.012840803,
-0.023366837,
0.029338667,
-0.009902827,
0.029092124,
-0.003311215,
-0.002571585,
0.009772707,
-0.0090056835,
0.0015605856,
-0.016504712,
0.0045370837,
0.017422402,
0.015929444,
-0.0064820372,
0.021380793,
-0.007944177,
-0.0017352205,
-0.035694007,
-0.01049864,
0.005574621,
0.005293835,
0.0008718905,
-0.023490109,
0.0063861595,
-0.016901921,
-0.034242142,
-0.0019175599,
-0.013046255,
-0.011751903,
0.0024397525,
-0.028653823,
0.016189685,
-0.016901921,
0.009491921,
0.0021846485,
-0.0017335084,
0.031447984,
-0.0209151,
0.023585986,
0.0085810805,
0.028078556,
0.022065636,
-0.0073963027,
0.02025765,
-0.0053041074,
0.001758334,
-0.005471894,
-0.022408057,
-0.0009844615,
0.011101302,
0.023873622,
-0.03446129,
-0.030297447,
-0.0213534,
0.017764824,
-0.009656284,
-0.0361597,
0.01237511,
0.02758547,
0.00035611828,
-0.0014664197,
-0.0055985902,
-0.17334741,
0.028900366,
0.008382476,
0.0010623625,
0.029996116,
0.022216301,
0.027037594,
-0.0063279476,
-0.014066672,
0.0017771671,
0.0161212,
-0.0032889578,
-0.043994304,
-0.045144837,
0.010957485,
0.0020904827,
-0.019120812,
0.029557817,
0.023558592,
0.009827495,
0.028133344,
0.017504582,
0.01660059,
-0.013087346,
-0.014819998,
0.026256874,
-0.03174931,
0.0013063377,
-0.00690664,
-0.015107633,
-0.023695562,
0.003564607,
0.014614546,
0.0017420689,
0.01420364,
0.010121977,
0.008937199,
-0.008718049,
-0.013559888,
0.024476282,
0.023681864,
0.0339956,
-0.012601108,
0.011265664,
-0.013251709,
0.027064988,
0.032269794,
-0.012916136,
0.02057268,
0.015436357,
0.018408574,
0.0012515503,
0.003116035,
0.021326005,
-0.01586096,
-0.0018816057,
0.014436487,
-0.011977901,
0.0031588376,
0.01538157,
-0.0049651107,
-0.022777872,
0.021709517,
0.030352235,
-0.020463103,
-0.010087735,
-0.017901791,
0.007738724,
-0.011306755,
0.012094324,
-0.007293576,
0.02169582,
0.006766247,
-0.008868715,
0.041802805,
0.0011419754,
0.0049514137,
0.008355082,
0.024147557,
0.023175081,
0.007533271,
0.0030150206,
-0.030598776,
0.008731746,
0.0068792463,
0.020312438,
-0.011073909,
0.023928408,
0.0025219338,
0.0028249766,
0.04262462,
-0.029448241,
-0.0017163873,
-0.015915748,
0.006423826,
0.013950248,
-0.0007229372,
0.015395267,
0.0134092225,
-0.008375628,
0.021380793,
-0.007067578,
-0.0370363,
0.008403022,
0.010916394,
-0.0067080352,
-0.010964334,
-0.004156996,
0.025065247,
-0.037967686,
-0.0032358824,
-0.004814445,
-0.005037019,
0.008985138,
-0.004975383,
0.013457161,
0.01834009,
-0.007786663,
-0.020668557,
-0.025859665,
0.048569053,
-0.0030475506,
-0.0014561471,
0.00771133,
-0.009594648,
-0.011019121,
-0.13631111,
-0.0063142506,
0.029475635,
0.0116354795,
-0.016395137,
0.0058485577,
-0.0042460253,
0.010238401,
0.00313658,
0.03859774,
-0.0020767858,
-0.013128437,
-0.011491663,
-0.018709905,
0.016354047,
0.0156829,
-0.0012404216,
-0.02544876,
-0.007663391,
0.03325597,
0.014080368,
0.0018302425,
0.004872657,
-0.003102338,
-0.008170174,
-0.006810762,
-0.0008676103,
0.052568536,
-0.0067114597,
0.005841709,
0.02261351,
-0.013539342,
0.0009159773,
-0.021791698,
-0.013340739,
0.0032598518,
-0.005917042,
-0.0031211711,
0.03637885,
-0.009991857,
0.008272901,
0.010382217,
0.036844544,
-0.00636219,
0.018175729,
-0.012553169,
-0.005499288,
0.011916265,
0.01925778,
-0.012560017,
-0.023161385,
-0.023257263,
-0.0071086683,
0.0038899072,
0.013272254,
-0.012320322,
0.0009339544,
0.013066801,
-0.035721403,
-0.008902957,
-0.010245249,
-0.00078628515,
-0.0405153,
-0.012840803,
0.028434673,
0.00054573413,
-0.009108409,
-0.04761027,
0.02205194,
-0.033036817,
-0.036844544,
0.0069956696,
-0.005037019,
0.022380663,
-0.036598,
-0.005259593,
-0.0057184375,
0.024544766,
-0.002126437,
0.014518668,
0.0054342276,
-0.0103411265,
0.0034841378,
-0.018244212,
0.0026948566,
0.009971311,
0.011402633,
0.02553094,
0.008108539,
-0.029420847,
-0.042021956,
0.031091863,
0.008683807,
-0.03673497,
0.018600332,
0.017258039,
-0.024284527,
-0.030900108,
0.028379887,
0.021504065,
-0.018490756,
-0.025078945,
-0.06415608,
-0.006769671,
0.0129435295,
0.0036844544,
-0.01729913,
0.008252356,
0.025188519,
-0.009567254,
-0.002400374,
0.0033968205,
-0.009334408,
0.03473523,
-0.011176635,
-0.011916265,
-0.031694528,
-0.0059889504,
0.021298612,
-0.0063861595,
0.0066874903,
0.019531718,
-0.0036433637,
-0.0034481836,
0.0073278183,
0.0142721245,
0.0067114597,
0.008629019,
-0.004862384,
0.01311474,
-0.01263535,
0.0014492986,
-0.02061377,
-0.03407778,
-0.014066672,
-0.008779685,
-0.017107373,
-0.0009622042,
0.0027393713,
0.013279103,
0.023161385,
0.0243941,
-0.035803583,
-0.019285174,
0.007334667,
-0.022339573,
-0.0032735488,
0.013881764,
-0.0064204014,
0.008718049,
0.0050644125,
-0.02357229,
0.039118223,
0.022846356,
-0.024983067,
-0.02117534,
-0.009211136,
0.0019432415,
0.016792346,
0.010217855,
-0.0072182436,
0.0017489174,
0.013518797,
-0.011779296,
0.032598518,
-0.008046903,
-0.0028985972,
0.0013816704,
-0.009820646,
-0.036324065,
0.000352052,
-0.024996763,
-0.012566865,
-0.0019500899,
0.015984232,
0.015929444,
0.008629019,
0.008183871,
-0.019326264,
0.034653045,
-0.0063895835,
0.025558334,
-0.008923502,
0.012183354,
-0.031584952,
0.038351197,
0.025859665,
0.005708165,
-0.041501474,
0.0028831882,
-0.02057268,
0.009491921,
-0.011786145,
0.010690397,
-0.009491921,
0.014025581,
-0.012149111,
-0.0051705632,
-0.011443724,
-0.0071908496,
0.022627207,
0.0077455724,
0.011334149,
0.0200385,
-0.007909935,
-0.028736005,
-0.007629149,
-0.0005564348,
-0.04317249,
-0.016093805,
0.009046773,
0.024298223,
0.01869621,
-0.0037666354,
-0.0013457162,
0.009615193,
0.010313733,
0.019011237,
-0.014080368,
-0.026845839,
-0.012423049,
0.01581987,
-0.0021658153,
0.02792789,
0.013066801,
-0.0041843895,
0.001215596,
-0.008807079,
0.048432086,
-0.022750478,
0.03547486,
-0.021805396,
0.026982807,
-0.018929055,
-0.059279993,
-0.015943142,
-0.0019141356,
-0.018175729,
0.016792346,
0.028653823,
-0.020545285,
0.06914173,
0.013148982,
-0.012861348,
0.003211913,
0.028736005,
0.004348752,
-0.0065197037,
0.010731487,
0.01250523,
-0.013525646,
0.003930998,
-0.017764824,
0.04188499,
-0.010334278,
-0.035694007,
-0.0044480544,
-0.021613639,
0.011923114,
-0.0007965578,
0.002236012,
0.024859795,
0.010074038,
-0.0038967556,
0.013073649,
-0.03054399,
-0.0047425367,
0.007184001,
-0.013963945,
0.0007002518,
-0.040022213,
-0.008553687,
0.007081275,
-0.033392936,
-0.0057287104,
0.012779167,
0.0014450183,
0.005232199,
-0.04087142,
0.0023644199,
0.0024174952,
-0.013258557,
0.027503287,
-0.023558592,
-0.016189685,
-0.015367873,
-0.031447984,
-0.019723473,
0.027352622,
0.000009329646
] |
The integrin family of heterodimeric cell-surface receptors are fundamental in cell-cell and cell-matrix adhesion. Changes to either integrin-ligand affinity or integrin gene expression are central to a variety of disease processes, including inflammation, cardiovascular disease and cancer. In screening for novel activators of integrin-ligand affinity we identified the previously uncharacterised multi-transmembrane domain protein Fam38A, located at the endoplasmic reticulum (ER). siRNA knockdown of Fam38A in epithelial cells inactivates endogenous beta1 integrin, reducing cell adhesion. Fam38 | [
-0.024016684,
0.0018474372,
-0.028432189,
-0.024894543,
-0.009459927,
0.011169788,
-0.03802314,
0.002769518,
-0.023492588,
-0.014347118,
0.010141251,
-0.012689666,
0.013849228,
0.032231882,
-0.013705102,
0.0032608577,
0.027567431,
-0.008431389,
-0.020400424,
-0.0029938964,
-0.022156144,
0.012886202,
-0.0042648283,
-0.017688228,
-0.029192127,
0.016980698,
0.01901157,
-0.05073246,
-0.024187015,
-0.023034004,
-0.0019833746,
0.006970472,
-0.010495015,
0.0013266171,
0.0036555673,
0.013665794,
0.020387322,
-0.00198665,
0.019732201,
0.004536703,
0.021186566,
0.0055685164,
0.0073963,
0.0030086366,
0.005254059,
-0.006806692,
0.014727088,
-0.009433722,
-0.023689123,
0.02579861,
0.00087376573,
0.015683563,
-0.0123817595,
-0.024580086,
-0.010829126,
-0.013429951,
0.0031232825,
0.00019581933,
-0.00378004,
-0.016967596,
-0.0056897136,
-0.0035474724,
-0.017282054,
0.009400966,
-0.013338234,
0.039778862,
0.0035572993,
0.01172664,
0.0014936726,
0.004910121,
0.037551455,
0.025235206,
-0.012139366,
-0.01632558,
0.01577528,
-0.021959608,
-0.02197271,
0.0072783786,
-0.012846895,
0.007867986,
0.0030495815,
-0.008188995,
-0.00045817424,
0.022575421,
0.022771956,
0.00018763034,
0.0043860255,
0.014163685,
0.0035245433,
0.011870767,
0.00037014254,
0.012486579,
0.0024239423,
0.026270295,
-0.014543654,
0.0026581476,
-0.00011515774,
0.02383325,
-0.0008573877,
-0.00887687,
0.0021193118,
0.0071473545,
0.00394382,
-0.01484501,
-0.025733097,
-0.009852998,
0.0049068457,
-0.022942288,
0.005240957,
-0.0035081652,
-0.023571203,
0.020596959,
0.018487474,
-0.015133262,
0.029323151,
-0.015500129,
0.028170142,
-0.0017770118,
-0.013049982,
-0.016181454,
0.0032543065,
0.029611405,
-0.00473979,
-0.024200117,
0.030607186,
0.012853446,
0.010822576,
0.0009507423,
-0.014098173,
-0.0019571697,
0.011078072,
0.016076634,
0.009984022,
0.006970472,
-0.014609166,
0.010527772,
-0.011765948,
0.0055423114,
-0.012899305,
-0.029113514,
0.0139278425,
0.03008309,
-0.020845905,
-0.004202592,
0.004844609,
0.033384893,
0.018421963,
-0.006787039,
0.020570755,
0.016194556,
0.0028530457,
-0.0050116647,
-0.004212419,
-0.015578743,
-0.0057290206,
-0.0040126075,
-0.023911864,
0.008752397,
-0.0043860255,
-0.0052442322,
0.005358878,
0.0026712501,
0.007422505,
0.0120410975,
0.042111088,
0.022313373,
-0.009014445,
0.023125721,
-0.0029709672,
-0.00086230115,
0.00063833216,
0.006865653,
-0.009833345,
-0.0021504299,
0.0055750674,
0.0023256745,
-0.0008770413,
0.006839448,
-0.01654832,
-0.022221657,
-0.009093059,
0.013993354,
0.03655567,
0.0069180625,
-0.013318581,
-0.012630706,
0.025968939,
-0.018893648,
-0.010770165,
-0.024475267,
-0.007160457,
0.010527772,
0.006898409,
-0.019221209,
-0.6389774,
-0.027986707,
0.029270742,
0.015382208,
-0.0012643808,
0.042713795,
0.014609166,
-0.0015297042,
0.010874985,
0.00077181275,
-0.018775728,
0.012250736,
-0.011327017,
0.0011022387,
-0.029558996,
-0.022549216,
-0.027043335,
-0.033384893,
0.02579861,
0.0038750323,
-0.016718652,
0.009649911,
-0.0013741133,
0.008916178,
0.0081955455,
0.010495015,
0.018068198,
-0.031105077,
-0.016246965,
0.026545445,
-0.028432189,
0.027960503,
-0.0032706845,
0.004143631,
0.049553245,
-0.008627925,
0.01512016,
0.034826156,
0.034983385,
0.027436407,
-0.014635371,
-0.004114151,
-0.0031232825,
0.0047594435,
-0.009584399,
0.012283492,
-0.0015698302,
0.005768328,
0.012846895,
-0.011497349,
-0.0008365058,
0.004146907,
-0.05159722,
-0.014216094,
0.0015239719,
0.008097278,
0.02898249,
-0.013469258,
0.017321361,
0.008306916,
0.008726193,
0.036293626,
0.00009929156,
-0.019627383,
0.008595169,
-0.008791705,
-0.023859454,
0.012702769,
0.0081300335,
0.019810816,
0.009197879,
0.030397547,
0.005100106,
0.024239425,
0.019968044,
0.036503263,
0.004038812,
0.041770425,
0.0027646045,
0.02235268,
0.009400966,
-0.0048609874,
-0.009309249,
0.0028923529,
0.010101944,
0.02230027,
-0.029768633,
0.015591846,
-0.008647579,
0.007867986,
0.013954047,
0.0021209496,
-0.03309664,
-0.0410891,
-0.014006456,
0.011307363,
-0.0017442559,
0.028589418,
0.004425333,
-0.0077893715,
0.013377542,
-0.022496806,
0.0072521735,
-0.01320721,
0.009656463,
-0.01725585,
-0.043028254,
0.016561422,
0.041927654,
-0.013836125,
0.0015616412,
-0.012584847,
-0.015840791,
-0.017334463,
-0.021605844,
-0.018972263,
-0.0020390598,
0.013875432,
0.012427618,
-0.044967405,
0.0052671614,
-0.0026859902,
0.0027973605,
-0.0015133262,
0.032624956,
0.0042582774,
-0.020675573,
-0.010652244,
0.0028071874,
-0.0038160714,
0.015264286,
-0.006970472,
0.011883869,
-0.019981148,
0.012224531,
0.016731754,
0.0034000706,
0.012859997,
0.0038586543,
-0.022496806,
-0.029323151,
-0.017662024,
0.024147708,
-0.0064594788,
-0.017164133,
-0.011058418,
-0.0086017195,
0.009708872,
0.023571203,
-0.009073406,
-0.007985908,
0.019876327,
-0.007527324,
0.015080852,
0.028405985,
-0.02503867,
-0.01764892,
-0.021736868,
0.006787039,
-0.02481593,
-0.0012897666,
0.003054495,
-0.019168798,
0.003714528,
0.012584847,
0.004897019,
0.0040289853,
0.0019522563,
-0.010881536,
-0.04294964,
-0.0007943325,
-0.02109485,
-0.030502368,
0.01780615,
-0.0023174854,
0.018526781,
-0.017937174,
0.014347118,
0.0034328266,
-0.0127158705,
-0.004327065,
-0.03692254,
-0.014858112,
-0.010324684,
0.04085326,
0.020675573,
0.02438355,
0.018068198,
0.00084428536,
0.01692829,
-0.0410891,
0.0008328208,
-0.0072849295,
0.01243417,
-0.00042992222,
-0.008411735,
0.01418989,
0.018670907,
-0.021278284,
0.0031429362,
0.012139366,
-0.010914292,
0.010658795,
-0.0120410975,
0.010481914,
-0.0037341816,
-0.015552538,
-0.013141698,
0.01232935,
-0.011883869,
0.0018605395,
0.024619393,
0.0052147517,
-0.012578296,
-0.007854884,
0.008641027,
-0.011562861,
-0.007894191,
-0.019876327,
-0.011779049,
-0.016810369,
0.0064070695,
0.01835645,
0.0007808206,
-0.015853893,
-0.002320761,
-0.009407517,
0.01358718,
0.0043237894,
-0.040617414,
-0.021736868,
0.014085071,
0.018264733,
0.02361051,
-0.00457601,
-0.006721527,
0.01660073,
-0.004481018,
0.04504602,
-0.010678449,
0.015984917,
0.012283492,
0.0043630963,
0.014360221,
-0.0004983003,
-0.035271637,
0.0202694,
0.009721975,
-0.0010760339,
0.01764892,
-0.0036457404,
0.025562765,
-0.008994792,
0.008994792,
-0.002500919,
-0.02235268,
0.012905856,
0.017295158,
0.048085775,
0.018146813,
0.016797265,
0.01594561,
-0.011222199,
-0.003966749,
0.0029218332,
0.020125274,
-0.01243417,
-0.010141251,
-0.0039569223,
0.01200179,
-0.008247956,
0.0004692294,
0.0093158,
-0.03335869,
-0.010108495,
0.020649368,
0.01101256,
0.009034099,
0.016299374,
-0.003812796,
-0.0066592903,
-0.042923436,
0.04902915,
0.01391474,
-0.025824813,
-0.0060303756,
-0.019601177,
0.00517872,
0.0009474667,
-0.0051164837,
0.0017868386,
0.00028436285,
0.033725556,
0.008922729,
0.00043319783,
0.007298032,
0.04334271,
-0.0197191,
0.030371344,
0.009997125,
-0.0038521031,
-0.0076386943,
-0.004196041,
-0.010442606,
0.04525566,
0.017439283,
-0.0104884645,
0.0030938021,
-0.0052016494,
-0.027410204,
-0.0057060914,
-0.009289595,
-0.022169245,
-0.03320146,
-0.015159467,
-0.008090727,
0.013796818,
-0.0058272886,
0.040617414,
-0.011287711,
-0.014229197,
-0.031131282,
0.0017131377,
0.012807587,
0.01895916,
0.009663014,
0.0020996581,
0.018500576,
0.0065348176,
-0.008365877,
-0.028091528,
-0.026741982,
-0.0063579353,
-0.008247956,
-0.009846447,
-0.026990926,
0.007625592,
-0.0019571697,
0.016574524,
0.030004477,
-0.0047627194,
-0.042268313,
0.018251631,
0.003933993,
0.011818357,
0.0045923884,
0.023479486,
0.027986707,
0.03320146,
-0.027934298,
-0.00048601683,
0.021618946,
0.00078573404,
-0.022719547,
0.009715423,
0.014373323,
-0.009866101,
0.0053719804,
-0.009721975,
-0.041403558,
0.004015883,
0.00662981,
0.008647579,
-0.012257287,
0.0034164486,
0.025195898,
0.012958265,
-0.00026245727,
-0.0006411983,
-0.017819252,
-0.014936727,
-0.0058764224,
0.015631152,
-0.009866101,
0.010966701,
-0.01851368,
0.0065544713,
-0.022929184,
0.014609166,
0.0027842582,
0.0111632375,
-0.0015337986,
-0.022077529,
-0.03626742,
-0.009676116,
-0.038337596,
0.0033083537,
-0.0103508895,
-0.014255402,
-0.026859902,
-0.017662024,
-0.017321361,
0.0050051133,
0.020439731,
-0.0007754978,
-0.038101755,
-0.018644704,
0.0019391539,
-0.000042506,
0.011674231,
0.01933913,
0.009518887,
0.015421514,
0.03254634,
-0.005977966,
-0.005732296,
0.0017622716,
-0.032415316,
-0.015971815,
-0.005221303,
0.004995287,
-0.020413525,
-0.0050051133,
-0.009138918,
0.0054473192,
-0.01933913,
0.018815033,
0.0014371686,
-0.014111276,
0.016902085,
0.01484501,
-0.0015043183,
-0.0012766643,
-0.0064365496,
-0.0040093316,
-0.024907647,
-0.015133262,
-0.0116349235,
-0.00832657,
-0.0049232235,
0.024082195,
0.007874537,
-0.019692894,
-0.010770165,
-0.02717436,
0.004130529,
-0.004091222,
0.0029021797,
0.029768633,
0.014373323,
-0.0030512195,
0.015749075,
0.014176788,
-0.009689218,
-0.017059313,
-0.012211429,
0.01616835,
0.0054833507,
-0.010023329,
0.015631152,
0.00014351214,
-0.026912311,
-0.002990621,
-0.004169836,
-0.007632143,
0.03199604,
0.00016081138,
-0.016718652,
-0.017491693,
-0.006452928,
-0.008660681,
0.000021739223,
-0.012414516,
0.0009974196,
-0.02274575,
0.000594521,
0.012322799,
-0.009486131,
-0.009473029,
-0.031733993,
-0.0053457757,
0.011549758,
-0.00052982796,
0.002052162,
-0.0016353423,
-0.016613832,
-0.015932508,
-0.011209096,
-0.027462613,
-0.017085519,
-0.0072783786,
-0.010370543,
0.02882526,
0.042006265,
0.019732201,
0.008175892,
0.040748436,
0.008621373,
0.005486626,
0.020701779,
0.006970472,
0.0024976435,
-0.009093059,
0.03335869,
0.02224786,
0.0071145985,
0.041167714,
-0.0068132435,
0.0345117,
0.011746294,
-0.015421514,
-0.014425733,
0.0017213267,
-0.0410891,
-0.031367127,
0.011104276,
-0.020793496,
-0.0029840698,
-0.03490477,
0.0010645693,
-0.013652692,
-0.003413173,
0.0039864024,
0.0018228702,
0.014032661,
-0.021003133,
0.04989391,
-0.0011104277,
0.011602168,
-0.0050378693,
-0.01484501,
0.0109536,
0.0006669936,
0.031262305,
0.0018523505,
0.009119265,
0.013344785,
-0.008699988,
-0.004471191,
0.0047365143,
-0.007920396,
-0.024527676,
-0.004602215,
-0.011130482,
-0.008057971,
-0.027331589,
-0.012283492,
-0.045124635,
0.007854884,
0.010206763,
-0.019050878,
0.027698455,
0.0061122654,
-0.010704653,
0.025012465,
0.0010801284,
0.015002239,
-0.02361051,
0.014910521,
0.010861882,
0.006164675,
-0.026741982,
-0.019142594,
0.008208648,
-0.002759691,
0.039071333,
0.020439731,
0.006662566,
-0.016941393,
-0.0025467773,
0.0053654294,
-0.018723316,
-0.02218235,
0.033542123,
0.0016680981,
0.019522563,
-0.005444044,
0.0038619298,
-0.006217085,
0.02624409,
-0.0018916577,
-0.0047856485,
-0.002222493,
-0.0012823966,
-0.016469706,
0.026650265,
-0.002256887,
-0.0053556026,
0.0041600093,
-0.027305383,
0.0021979262,
-0.026702674,
0.013069635,
-0.0058141863,
0.0138623305,
0.024842134,
-0.011864215,
-0.0010326322,
0.02147482,
0.0030577707,
0.0022110285,
-0.019889431,
-0.003763662,
0.04027675,
-0.008745846,
-0.004959255,
0.024501473,
-0.008136585,
-0.00007871671,
-0.011006009,
0.008732744,
-0.0017475315,
-0.023361564,
-0.01418989,
0.026204783,
0.010730859,
0.006865653,
0.022811264,
-0.025706893,
0.011202545,
-0.031052668,
-0.034328267,
0.012617603,
-0.04289723,
-0.021736868,
0.0077238595,
0.025287615,
0.016011123,
0.0018769176,
-0.012466925,
-0.0074356073,
0.028851466,
-0.036739107,
0.0049887355,
-0.0042320723,
0.009283044,
-0.015434617,
0.0098136915,
-0.014124378,
-0.018199222,
0.008215199,
-0.018225426,
-0.0075535285,
0.003429551,
-0.010108495,
0.015447719,
0.01737377,
-0.01073741,
0.016967596,
-0.007566631,
0.010940497,
0.00594521,
-0.0011824908,
0.002474714,
-0.027488817,
0.00441223,
0.016063532,
-0.005709367,
-0.0073831975,
0.014858112,
-0.021278284,
-0.0012283492,
-0.0068132435,
-0.015565641,
-0.014451938,
-0.0026450453,
-0.008948933,
-0.001523153,
-0.020505242,
-0.0024124777,
-0.021121055,
0.025667585,
0.008483798,
-0.019496359,
0.007802474,
0.012427618,
0.00550628,
0.002304383,
-0.012296595,
-0.01692829,
-0.00012293729,
-0.01944395,
-0.019090185,
0.010770165,
-0.016836572,
0.024606291,
0.0003367724,
-0.00980714,
-0.023466382,
0.0014650112,
-0.05167583,
-0.027515022,
-0.0013569164,
-0.009374761,
-0.0037243548,
0.009034099,
-0.009086508,
0.003380417,
0.0031969836,
-0.0112353,
-0.012060751,
-0.007094945,
0.0029922586,
-0.028510803,
0.015604948,
0.0011128844,
-0.037446633,
-0.022824366,
0.030214114,
0.014622269,
0.0027269353,
0.027803274,
-0.010593283,
0.028039118,
-0.015041545,
0.028746646,
-0.0123817595,
0.023073312,
0.040774643,
-0.013069635,
-0.011261505,
-0.007881088,
-0.009748179,
-0.013560975,
0.02361051,
0.0027252974,
0.006361211,
0.007088394,
0.023348462,
-0.02607376,
0.020950723,
-0.0065544713,
0.027148155,
0.004399128,
-0.0015190585,
0.011582514,
0.02777707,
-0.0015837515,
-0.025064874,
-0.026990926,
-0.0036555673,
-0.0101478025,
0.0069180625,
-0.00887687,
-0.026768185,
-0.014268504,
-0.019954942,
-0.010344338,
-0.0005126311,
-0.016718652,
-0.0152773885,
-0.012073854,
0.00071817485,
0.0042058676,
-0.0050968304,
-0.011923176,
-0.012349004,
-0.007324237,
-0.035743322,
-0.008536208,
0.015788382,
-0.008798256,
-0.025353128,
0.02498626,
-0.008686885,
0.003478685,
0.0028939906,
-0.010999458,
0.010036432,
-0.0021160361,
0.20072864,
-0.012846895,
-0.0033869683,
0.0028776126,
0.0018195946,
0.0026237539,
-0.0019506185,
-0.003927442,
-0.0036457404,
0.0076124896,
0.03375176,
0.0029332978,
-0.018893648,
-0.005198374,
0.014071968,
0.003445929,
-0.020151477,
0.0028530457,
-0.032284293,
0.010331236,
0.021121055,
-0.0116349235,
-0.015591846,
-0.017950276,
0.04892433,
0.0063972427,
-0.022601625,
-0.010396748,
0.019352231,
-0.002915282,
-0.029401766,
-0.005594721,
0.004887192,
0.020439731,
0.01567046,
-0.005555414,
-0.01052122,
0.021134157,
0.008503452,
0.018932955,
-0.0054473192,
-0.0024452338,
-0.023413973,
-0.013508566,
-0.014085071,
0.012624154,
0.0112353,
-0.009335454,
0.002517297,
0.014923624,
-0.036136396,
0.015762176,
0.003907788,
0.021998916,
-0.02197271,
-0.0065544713,
0.0073831975,
0.037761092,
0.00293166,
0.0073700952,
-0.0012267114,
-0.004992011,
-0.01885434,
0.029061103,
-0.022798162,
0.03983127,
-0.019968044,
-0.0018048544,
0.016744856,
-0.017124826,
0.00249273,
-0.00610899,
-0.018435065,
0.015133262,
-0.013239967,
-0.0006956551,
0.025444845,
0.0016115941,
0.024855236,
0.024619393,
0.017950276,
-0.001165294,
-0.032467727,
0.015382208,
-0.031367127,
-0.029611405,
0.012486579,
0.007101496,
-0.008889972,
-0.028458394,
0.0003556071,
-0.008346223,
-0.009440273,
0.0039569223,
-0.0025860844,
-0.009669565,
-0.010560527,
-0.007474914,
-0.0086017195,
-0.004372923,
-0.024645599,
0.08306916,
0.0021700836,
0.02076729,
-0.03210086,
0.0013110581,
0.0013241604,
0.011346671,
0.005165618,
-0.008896524,
-0.00057404855,
-0.019299822,
-0.003347661,
-0.016849676,
-0.021527229,
0.009774384,
0.013213762,
-0.023649817,
0.0147401905,
-0.012060751,
-0.025444845,
-0.007376646,
0.0023551548,
0.032284293,
-0.007363544,
0.009505785,
-0.024671802,
0.0012635619,
0.021527229,
-0.029427972,
-0.01627317,
0.017766843,
0.007442158,
0.003445929,
0.0033460231,
0.00662981,
0.008975138,
-0.011241851,
-0.02613927,
0.020675573,
-0.009119265,
-0.02459319,
0.032231882,
0.021278284,
-0.01747859,
0.0054473192,
0.035743322,
0.023584304,
-0.004975633,
-0.0038160714,
-0.017072417,
-0.020741086,
0.0008291357,
-0.004625144,
0.046827946,
0.0020832801,
-0.012231083,
-0.016286273,
0.005326122,
-0.010973252,
-0.023859454,
0.00654792,
0.03435447,
-0.016246965,
0.00016470115,
0.01451745,
-0.16498531,
0.02887767,
0.005725745,
-0.017046211,
0.029663814,
-0.0019162247,
-0.010108495,
0.0058141863,
-0.0059190053,
-0.004405679,
0.032860797,
-0.014347118,
-0.022654034,
-0.03485236,
0.011333569,
0.008831012,
-0.0011914987,
0.014976033,
0.012401413,
0.012905856,
0.022418192,
-0.03204845,
-0.0067804875,
-0.019352231,
0.0029120066,
0.0005724107,
0.013626487,
-0.025195898,
-0.016574524,
0.0008926004,
0.00095401786,
0.010619489,
0.05791257,
0.0020881935,
0.016902085,
0.0029447624,
0.0021553433,
-0.0023076588,
0.0030201012,
0.014962931,
0.031000258,
0.024920749,
-0.00953199,
0.0073831975,
-0.020976929,
0.019155696,
0.007933498,
0.0017475315,
0.028563213,
-0.018749522,
0.021605844,
-0.018552987,
0.014425733,
0.034537904,
0.052645408,
0.021959608,
-0.018657805,
0.0041731116,
0.009636809,
-0.010115046,
-0.015316696,
0.008300365,
0.029192127,
-0.007356993,
0.0077173086,
-0.030056886,
-0.010514669,
0.0208197,
-0.017596511,
0.025510356,
-0.02109485,
-0.014425733,
0.001758996,
-0.023309154,
0.011857664,
0.023060208,
-0.009407517,
-0.010842229,
0.0045268764,
-0.0043630963,
-0.017976481,
-0.002884164,
-0.01813371,
-0.028851466,
-0.008320019,
-0.0058993516,
0.0052671614,
0.023754636,
-0.0030348415,
-0.0037178036,
0.026113067,
-0.038442418,
0.005692989,
-0.02042663,
0.030633392,
0.0152118765,
0.007376646,
-0.011916625,
-0.008739295,
0.0015116885,
0.025837915,
-0.032965615,
0.0009802227,
0.014281606,
0.0033329208,
-0.010501566,
0.000107787644,
-0.013940944,
0.045570116,
-0.024606291,
-0.00947958,
-0.014111276,
-0.00871309,
0.029558996,
-0.0052114762,
0.024501473,
0.002265076,
-0.0057617766,
0.004992011,
-0.03330628,
0.07321616,
0.009112713,
0.008372428,
0.0143340165,
-0.0044613644,
-0.032887,
-0.11299502,
0.008595169,
0.032834593,
0.0062432894,
-0.0012963179,
0.024422858,
0.0022683516,
0.0143995285,
-0.021632047,
0.012165571,
-0.030974053,
-0.004723412,
0.001531342,
-0.03566471,
0.009106162,
0.0059026275,
0.0035900553,
-0.0100167785,
-0.02717436,
0.02218235,
-0.02212994,
-0.02619168,
0.005742123,
0.0028383054,
-0.0010817662,
-0.0019014846,
-0.02579861,
0.018906752,
-0.012578296,
0.0102198655,
0.009584399,
-0.006613432,
0.02541864,
0.008981689,
-0.016784163,
-0.031838812,
0.009433722,
-0.010232967,
0.02131759,
-0.0070490865,
0.013135147,
0.0035212678,
-0.0180813,
-0.0121066095,
-0.0071997643,
-0.005489902,
-0.005100106,
0.019457052,
0.025759302,
-0.011962484,
-0.030449959,
-0.027541228,
-0.03521923,
-0.0125127835,
0.022785058,
-0.006754283,
0.006891858,
0.016640037,
-0.01582769,
0.0005748674,
0.0015403499,
0.009197879,
-0.009597502,
0.0042550014,
0.039071333,
-0.017321361,
-0.0015640979,
-0.023518793,
0.024894543,
-0.013377542,
0.0031052667,
-0.014897419,
-0.015356002,
-0.011903523,
-0.019365335,
0.009387864,
-0.019299822,
-0.015722869,
0.003021739,
-0.021867892,
-0.014530552,
-0.02712195,
0.0077238595,
-0.010475362,
0.032624956,
0.002980794,
0.0024665252,
-0.0059026275,
0.014989136,
-0.020937622,
-0.021658253,
0.04043398,
0.014569859,
-0.00353437,
-0.0062203603,
0.009931613,
0.0044089546,
-0.020727983,
0.008143136,
0.027593637,
-0.04470536,
0.013318581,
-0.06687461,
0.005466973,
-0.009577848,
0.016351784,
0.034799952,
-0.015159467,
-0.004651349,
-0.0064234473,
0.01040985,
0.012427618,
-0.004585837,
0.017085519,
0.011464592,
0.003152763,
-0.036188804,
-0.020976929,
0.053064685,
0.008084175,
0.03165538,
0.055030044,
-0.012977919,
-0.0076386943,
-0.012368658,
0.0093158,
0.006800141,
-0.010606386,
-0.028930081,
0.0048413337,
-0.018107506,
0.020282501,
-0.008103829,
-0.02761984,
-0.029270742,
0.002003028,
0.008359326,
-0.016954495,
-0.012335901,
0.017937174,
0.026912311,
0.021107953,
-0.017268952,
-0.0301355,
0.017950276,
0.0062105334,
0.014831907,
0.0028235654,
-0.05068005,
-0.008025215,
0.012139366,
-0.002199564,
0.017557204,
0.0068787555,
-0.006246565,
-0.012086956,
0.008483798,
-0.005457146,
0.011333569,
-0.02613927,
-0.024881441,
-0.024829032,
0.015958713,
0.012879651,
0.0038521031,
0.016705548,
0.012879651,
-0.02443596,
-0.04310687,
0.0016484446,
0.014622269,
-0.016784163,
-0.008247956,
-0.005755225,
-0.0015501766,
0.012014893,
0.023584304,
0.027462613,
-0.010069188,
-0.007206315,
-0.01363959,
0.0102198655,
0.028039118,
-0.0003038117,
-0.007566631,
0.013370991,
0.01358718,
-0.0038848592,
-0.009355107,
0.0031969836,
0.024632497,
-0.0020587132,
0.019679792,
0.025615174,
0.005735572,
0.008143136,
-0.005123035,
0.011530104,
0.0055259336,
0.012191775,
0.006289148,
0.025248308,
0.016364887,
0.015382208,
-0.013220313,
-0.009669565,
-0.013069635,
0.017439283,
-0.015722869,
-0.031812605,
-0.024344243,
-0.0059321076,
0.003413173,
0.012191775,
0.018684011,
-0.0025860844,
-0.0062039825,
-0.011759397,
0.013056533,
-0.020190785,
-0.015460822,
0.02717436,
0.026650265,
0.011412183,
-0.023151925,
-0.016587628,
0.02119967,
0.021330694,
0.031602968,
-0.00438275,
0.027383998,
-0.023872558,
0.0029824318,
-0.00097612815,
-0.0093158,
-0.000765671,
-0.0071145985,
0.012597949,
-0.012899305,
0.0057814303,
-0.016535219,
0.09292216,
0.018435065,
-0.008300365,
0.010232967,
-0.008208648,
0.013980252,
-0.004366372,
0.014596064,
-0.03828519,
-0.043761987,
-0.010318133,
-0.0035736773,
-0.0023486037,
-0.053012274,
-0.014019559,
0.025274513,
-0.0043761986,
0.007533875,
0.0040846705,
-0.007966254,
-0.004641522,
-0.02761984,
-0.018539883,
0.005647131,
-0.044862587,
0.0027973605,
0.014543654,
0.03194363,
-0.014347118,
-0.030345138,
0.0038914103,
-0.013357888,
-0.031000258,
-0.006623259,
0.02882526,
-0.013560975,
-0.025431741,
-0.020649368,
0.0058895247,
0.037944525,
0.0067477315,
0.017871661,
-0.02438355,
-0.03058098,
0.0143995285,
0.013357888,
-0.029742429,
0.004110875,
-0.016784163
] |
PEROXISOMES are cytoplasmic organelles which are important in mammals in modulation of lipid homeostasis, including the metabolism of long-chain fatty acids and conversion of cholesterol to bile salts (reviewed in refs 1 and 2). Amphipathic carboxylates such as clofibric acid have been used in man as hypolipidaemic agents and in rodents they stimulate the proliferation of peroxisomes. These agents, termed peroxisome proliferators, and all-trans retinoic acid activate genes involved in peroxisomal-mediated β-oxidation of fatty acids1–4 | [
-0.0093914345,
-0.008108379,
-0.013505147,
-0.021904528,
-0.040396396,
0.02355795,
-0.012400662,
0.029788043,
-0.0036805163,
-0.007956265,
0.038835566,
0.016957492,
0.005558803,
0.00039062084,
-0.016428396,
0.008822657,
0.032433517,
0.008954931,
-0.013346419,
0.01711622,
-0.03185151,
0.008121607,
-0.016772307,
-0.013121554,
0.010231373,
0.009199638,
0.01781727,
-0.03574036,
-0.01641517,
-0.025634648,
0.010409942,
-0.019245828,
0.003581311,
0.015462798,
0.027856847,
0.0019030882,
0.016534215,
-0.0004402235,
0.004408022,
-0.0013467119,
0.0059523177,
0.021282842,
-0.019497147,
0.0098411655,
-0.0019080485,
0.003306843,
-0.010052803,
-0.015013068,
-0.0144972,
0.02199712,
0.023703452,
0.031401783,
-0.0032721213,
-0.0044146357,
-0.016719399,
-0.0028207372,
-0.014946931,
0.02310822,
-0.018690277,
-0.03640173,
0.0024883994,
-0.0061904103,
-0.027049977,
-0.0019411169,
0.0021196865,
0.034602806,
0.004021121,
0.0289944,
-0.00047659877,
0.008174516,
0.026190197,
0.01927228,
-0.015502481,
-0.0015947251,
0.0141268335,
-0.023875408,
-0.041322313,
-0.02531719,
-0.0027909756,
0.009695664,
0.03055523,
-0.00096890505,
0.012797483,
0.029761588,
0.009424503,
-0.0056050993,
-0.0005191744,
0.022367487,
-0.0055753374,
-0.012678437,
0.028280122,
0.031295963,
0.032089606,
0.023941545,
-0.011190357,
0.014629474,
0.0022718012,
0.022645261,
-0.00805547,
-0.012294843,
-0.0047717746,
0.02280399,
-0.013756467,
-0.009966825,
-0.023068538,
0.028015574,
-0.0125792315,
0.009212865,
0.020912476,
0.0107604675,
-0.016428396,
0.025634648,
0.0068054833,
-0.04777727,
0.032856792,
-0.016732626,
0.034549896,
0.007519761,
-0.01394165,
-0.010112327,
0.0025313883,
0.043253507,
0.023015628,
0.0021048055,
0.007169236,
-0.019893968,
-0.015330525,
-0.015767029,
-0.0008895408,
-0.0075991256,
0.011289562,
0.0053041764,
0.006392128,
-0.027248386,
-0.013677103,
0.008670542,
-0.008511814,
-0.00026413408,
0.0011053123,
-0.020846339,
0.024827778,
0.016970718,
-0.012010454,
0.003773108,
-0.01243373,
0.031719238,
0.018637368,
0.023293402,
-0.005244653,
0.01837282,
0.018650595,
-0.012149341,
0.023081765,
-0.008564724,
0.019642647,
0.030184863,
0.009722119,
0.027327752,
-0.011223425,
-0.017526269,
0.003816097,
-0.008782975,
0.0047552404,
0.019708784,
0.007711558,
0.009523708,
0.023015628,
0.012618913,
-0.0040145074,
0.005294256,
0.0168649,
0.0041831564,
-0.018095046,
0.03981439,
-0.032036696,
0.02708966,
-0.009014455,
0.021309298,
-0.008154675,
-0.034973174,
-0.0070501897,
0.009034296,
0.02355795,
-0.0066368342,
0.010886127,
0.0079099685,
0.0070501897,
-0.013650648,
0.02793621,
-0.031481147,
0.0043551126,
0.006365673,
-0.004136861,
-0.0204892,
-0.6277182,
-0.010476079,
-0.0017393995,
-0.027063204,
-0.0066732094,
0.032645155,
0.0144972,
-0.014880794,
-0.023174357,
-0.0068583926,
-0.0069311433,
0.014523655,
0.020952158,
-0.00918641,
-0.0045667505,
-0.023994453,
-0.019761695,
-0.019669103,
0.023094993,
-0.033862073,
-0.023280175,
-0.010958878,
-0.020581791,
-0.011633474,
0.013637421,
0.017751133,
0.041269403,
-0.022248441,
0.011547497,
0.042803776,
-0.0045865914,
0.03992021,
-0.010337192,
0.00025049338,
0.04984074,
0.003726812,
-0.008227426,
0.02355795,
0.04433815,
0.052935943,
-0.005572031,
-0.0073610325,
0.010383488,
0.0036044589,
-0.015290842,
0.020449517,
0.039364662,
0.010284282,
0.002984426,
0.00018404648,
0.00026909437,
0.002549576,
-0.0009069017,
-0.0039781323,
0.010013121,
0.016031576,
0.032962613,
-0.024589686,
0.0018386048,
0.022909809,
-0.0014145022,
0.013756467,
-0.02133575,
-0.04394133,
-0.023571178,
0.031084325,
-0.01957651,
0.0035978453,
0.017896635,
0.0053868475,
0.0062267855,
0.013915196,
-0.042565685,
-0.0042261453,
-0.0037598806,
0.005631554,
0.021375434,
0.020912476,
-0.011567337,
0.018055363,
0.023690224,
0.004110406,
-0.018782869,
-0.0065409355,
0.027010294,
0.009497253,
0.013326578,
0.00812822,
0.005727452,
-0.005165289,
0.016269669,
-0.0020089073,
0.00065806176,
-0.03701019,
-0.032354154,
0.013081871,
-0.010528988,
-0.010509147,
-0.005710918,
-0.015793482,
-0.001120193,
-0.029206038,
-0.020370154,
0.0042526,
0.02581983,
-0.0076255803,
-0.046189986,
-0.0023875406,
0.014695611,
-0.0351319,
0.008048856,
-0.011964158,
-0.0056050993,
-0.01049592,
-0.016944265,
-0.01555539,
0.0157538,
0.0012367594,
-0.0020485893,
-0.05097829,
0.018240547,
-0.010687717,
-0.009351753,
-0.014285563,
0.025647875,
0.01927228,
0.0020254415,
-0.011342471,
-0.0013285242,
-0.008095152,
-0.0041996907,
0.00046089126,
0.0033862074,
-0.016838444,
0.020211425,
0.02214262,
0.023121446,
-0.0033399116,
0.021520935,
-0.028571125,
-0.021626754,
-0.012797483,
0.00331015,
-0.028147848,
-0.0044377833,
-0.032036696,
-0.010482693,
0.0026388608,
0.0046229665,
0.0037797217,
-0.022274895,
-0.0015285882,
-0.030343592,
0.0228569,
0.028967945,
0.008002561,
-0.010198304,
-0.012638754,
-0.0073213507,
0.0087631345,
-0.00019159022,
0.012314684,
-0.0048643663,
0.03306843,
-0.018584458,
-0.00524796,
0.01787018,
-0.0017956158,
-0.0041335537,
-0.025303964,
0.013888741,
-0.010476079,
-0.023280175,
0.01993365,
-0.008048856,
0.021375434,
-0.0024387967,
-0.015277615,
-0.016229985,
0.010978719,
0.01225516,
-0.013485306,
-0.010502534,
0.015740573,
0.018782869,
-0.005416609,
0.035158355,
0.026944157,
-0.020753747,
0.032539338,
0.00028232174,
0.028306577,
0.015026295,
-0.009536936,
0.008730066,
-0.02562142,
-0.004847832,
0.0023858873,
0.01767177,
0.024100272,
0.019563284,
-0.037433464,
0.015595072,
-0.058729533,
0.02018497,
-0.018187637,
-0.011699611,
-0.004136861,
0.0033399116,
0.007916583,
-0.0016625153,
0.010581898,
-0.003855779,
-0.005482746,
-0.006706278,
0.0072089178,
0.015528935,
-0.01998656,
0.004007894,
-0.027777482,
-0.0069377567,
-0.026573792,
0.01973524,
-0.0035746973,
-0.00699728,
0.009292229,
0.015767029,
0.018161183,
-0.022975946,
-0.00038855406,
0.0054728254,
-0.013478693,
-0.0101321675,
0.025436237,
0.02119025,
0.009272388,
0.019946877,
-0.01142845,
0.021825165,
-0.00074899994,
0.009450957,
-0.00024015948,
0.026798656,
-0.006917916,
-0.0066236067,
-0.0072684414,
0.023981227,
0.010773695,
-0.014827885,
-0.005052856,
-0.0095038675,
0.007447011,
-0.017883407,
0.008657315,
-0.00037656675,
-0.0075991256,
0.014483972,
0.014563337,
0.041295856,
0.029285403,
0.0038756202,
-0.024087045,
-0.011263108,
-0.0029166357,
0.009027681,
0.023796042,
0.00630615,
-0.011064697,
-0.013372874,
-0.009768414,
-0.023703452,
0.008974772,
0.0252246,
-0.02461614,
0.01927228,
-0.0006845165,
0.0002556603,
-0.011309403,
0.017526269,
0.00010142708,
-0.030343592,
-0.024788097,
0.009583231,
0.02738066,
-0.008326631,
-0.014550109,
-0.047406904,
-0.00079818926,
0.015396661,
0.032989066,
0.0051322207,
0.009345138,
-0.00007610906,
-0.005734066,
-0.017076537,
-0.03510545,
0.014179743,
-0.016520988,
0.039391115,
-0.020647928,
-0.017393995,
-0.0023346313,
0.0049040485,
-0.0009647715,
0.015780255,
0.020224653,
-0.0043451916,
-0.0034192759,
-0.008723452,
-0.025237827,
-0.0048974347,
-0.020528883,
0.009417889,
-0.018809324,
-0.0003753267,
-0.009543549,
-0.002632247,
-0.014364926,
0.030952051,
0.0076255803,
-0.005836578,
-0.028227212,
-0.006537629,
0.010985333,
0.009226092,
0.02023788,
-0.0060746707,
0.02009238,
0.0061474214,
0.004110406,
0.0019245826,
-0.0073213507,
0.01369033,
0.006851779,
-0.00078496186,
-0.018531548,
-0.002466905,
-0.01331335,
0.013485306,
-0.0042492934,
-0.023399223,
-0.01236098,
-0.014880794,
-0.010952264,
0.0024288762,
-0.012896688,
0.022327805,
0.023822498,
0.023729905,
0.0052578803,
0.021031521,
0.0426715,
-0.003945064,
-0.0130488025,
-0.019497147,
-0.01566121,
-0.008015788,
0.0080686975,
-0.004890821,
-0.03277743,
-0.004040962,
0.010317351,
0.0024255693,
0.0068120966,
0.003298576,
0.03145469,
0.0035912315,
-0.013167849,
0.00074734655,
-0.008948318,
-0.0018964745,
0.016071258,
0.008121607,
-0.025714012,
0.025766922,
0.0010474426,
0.012744573,
-0.026587019,
-0.021388661,
-0.042883143,
-0.016481306,
-0.01580671,
-0.0034490374,
-0.009325298,
0.026216652,
-0.008696998,
-0.011977386,
-0.00064772787,
0.0181215,
-0.00012286988,
-0.012003841,
-0.02441773,
-0.057671342,
0.008445677,
0.01243373,
-0.036983732,
-0.026838338,
-0.008644088,
0.016124167,
0.013472078,
-0.004811457,
-0.021653209,
-0.000063450054,
0.027248386,
-0.0181215,
-0.0019229293,
-0.0023247106,
-0.033015523,
0.011223425,
-0.0003856606,
0.014457518,
-0.02406059,
0.006134194,
-0.0051520616,
0.019973332,
-0.018214092,
0.006048216,
-0.0022569203,
-0.0028207372,
0.010687717,
0.025198145,
0.01912678,
-0.0030290682,
-0.01374324,
-0.0027182251,
-0.012493254,
-0.0066236067,
-0.0008597792,
0.0033184171,
-0.028782763,
-0.012327911,
0.0014765054,
-0.011818658,
-0.0060978187,
0.0144178355,
0.025449464,
-0.007995946,
-0.030846233,
-0.0052810283,
0.026190197,
-0.033147797,
0.042010136,
-0.015925756,
-0.025502374,
-0.0020072537,
-0.008234039,
0.017552724,
0.014100379,
-0.04883546,
0.0031431543,
0.0051520616,
-0.011282949,
-0.016468078,
0.008816044,
0.0023561257,
0.027777482,
-0.024311911,
-0.054073498,
-0.030237773,
-0.0008353912,
-0.015819937,
-0.0077247857,
0.0035647769,
0.006068057,
0.012513095,
-0.0025065872,
-0.0061474214,
-0.009087205,
0.02133575,
-0.03306843,
-0.007235373,
0.017923089,
0.013022348,
0.01892837,
-0.0018038829,
0.009444344,
-0.034523442,
-0.017962772,
-0.029840952,
-0.023346312,
-0.02163998,
-0.02451032,
0.037089553,
0.035369992,
0.021745801,
0.0039781323,
-0.0025578432,
0.012605686,
0.005029708,
-0.017804043,
-0.0011681423,
0.0021544083,
-0.041560404,
0.02341245,
0.0127578005,
-0.008816044,
0.009556777,
-0.030211318,
0.03510545,
0.018650595,
-0.00143517,
-0.027909756,
0.0036011522,
0.00049892,
-0.018227318,
-0.0019526909,
-0.0008663929,
-0.02296272,
-0.023227265,
-0.027645208,
0.017856954,
0.028068485,
0.02341245,
-0.021441571,
0.044020694,
-0.03663982,
0.020039469,
0.012526322,
-0.0008122433,
0.00070394424,
-0.013730013,
-0.007420556,
-0.006554163,
0.0032754282,
-0.001886554,
0.0036739027,
0.025277508,
-0.021917757,
0.0278833,
-0.0070038936,
-0.006173876,
-0.0024950132,
0.005988693,
-0.015277615,
-0.013756467,
0.00493381,
-0.0015856313,
-0.04148104,
-0.007453624,
0.01867705,
-0.026600245,
0.012704891,
-0.0044774655,
-0.017579177,
0.014444291,
-0.0019311964,
0.026811885,
-0.026997067,
0.039020747,
0.016520988,
0.00906075,
-0.02567433,
-0.0068583926,
-0.014113606,
-0.0035780042,
0.049655557,
0.017102992,
-0.016044803,
-0.016216759,
-0.01374324,
-0.0015352019,
-0.015978666,
-0.035264175,
0.00074279966,
-0.01255939,
0.017341085,
-0.009298842,
0.016520988,
-0.03015841,
0.0030538696,
-0.025859512,
0.020621473,
-0.011256494,
-0.0030257613,
-0.0056646224,
0.036983732,
-0.006385514,
0.010853059,
-0.021785483,
-0.005204971,
0.0054000746,
-0.044073604,
-0.018505095,
-0.004160009,
-0.0013053763,
0.024087045,
0.012334525,
0.0068650064,
0.007519761,
0.034047257,
0.014510428,
-0.030184863,
-0.014021015,
0.037565738,
-0.008326631,
-0.009252547,
0.03288325,
0.024404502,
0.0067195054,
-0.017737906,
-0.009589845,
-0.023835724,
-0.014298789,
0.0049834126,
0.020052698,
0.0134985335,
-0.016997173,
-0.0035383222,
-0.020714065,
-0.002455331,
-0.0289944,
-0.020317243,
-0.0014740253,
-0.023319857,
0.004113713,
0.0058299643,
0.0061242734,
0.009417889,
-0.015436344,
0.0056348606,
-0.027248386,
0.032698065,
-0.008849112,
0.0060151475,
-0.020621473,
0.005099152,
-0.023333086,
0.00007052876,
-0.016229985,
-0.004761854,
0.018610913,
-0.017989226,
-0.05219521,
-0.025396556,
0.0053802337,
0.008002561,
-0.00029947597,
-0.013280282,
0.010092485,
-0.0059556244,
0.00017712278,
-0.018531548,
-0.020727292,
-0.0051289136,
-0.017645314,
0.020198198,
0.011408608,
-0.005409995,
-0.012089819,
0.004212918,
-0.04269796,
0.0018187637,
0.012923143,
-0.0058233505,
-0.0015988586,
0.0028306576,
-0.025423009,
-0.008518428,
-0.019311965,
-0.015819937,
-0.00687162,
0.002957971,
0.01399456,
-0.015647981,
-0.033385888,
-0.015634755,
0.0037135847,
-0.0053703133,
0.00062747346,
0.006911302,
-0.017804043,
-0.0016534216,
-0.021124113,
0.005572031,
-0.037380554,
0.04018476,
-0.008677157,
-0.03267161,
0.009576618,
0.0038326313,
-0.023848953,
-0.026520882,
-0.0044840793,
0.017327858,
-0.007235373,
0.005899408,
0.004202998,
-0.0026520882,
-0.00018290976,
0.0025545363,
-0.021428343,
-0.026190197,
0.03126951,
-0.01761886,
0.035608087,
-0.029206038,
-0.036216546,
-0.0037995628,
0.024788097,
-0.014338472,
-0.012189024,
0.017433677,
-0.013663876,
0.014179743,
-0.010833218,
0.0067393463,
0.02346536,
-0.0008589525,
0.04142813,
-0.026388608,
0.013081871,
0.010614966,
0.004444397,
-0.00549928,
-0.024576457,
-0.00893509,
0.002549576,
0.010535602,
0.0010813377,
-0.0055092005,
0.025462693,
-0.015581844,
0.013981333,
0.005330631,
-0.009708892,
-0.0033316445,
0.018571232,
-0.029523496,
-0.025303964,
-0.0037235054,
-0.023716679,
-0.0021626754,
0.009589845,
0.03349171,
0.008101766,
-0.0022833752,
0.008584565,
-0.03941757,
0.00026537417,
-0.027248386,
0.0055918717,
-0.026256334,
0.0289944,
0.0037235054,
-0.004649421,
-0.027221933,
0.007585898,
0.0069377567,
-0.0013979679,
0.004007894,
0.0016567284,
0.008577951,
0.010694331,
0.0033663663,
-0.01630935,
-0.006742653,
0.010158622,
-0.03222188,
-0.006851779,
0.017790817,
0.1705802,
-0.02587274,
0.0056778495,
0.019219372,
-0.00066839566,
-0.0011631821,
0.017050084,
-0.0062929224,
-0.0018369514,
0.012863619,
0.029126674,
-0.007837218,
-0.013114939,
0.001843565,
0.012625527,
-0.0041633155,
-0.027830392,
0.01142845,
-0.0013037228,
-0.02124316,
-0.021150569,
-0.0048941276,
-0.002541309,
-0.0010813377,
0.05079311,
-0.008736679,
-0.018756414,
0.009047523,
0.012585845,
0.019298736,
-0.006362366,
-0.0004160422,
-0.0061606485,
0.012096432,
0.02260558,
-0.006464878,
-0.020423062,
-0.00090194144,
0.016269669,
-0.0063722865,
0.012691664,
0.027010294,
-0.024179637,
0.0036639823,
-0.008868953,
0.020330472,
0.005714225,
-0.018584458,
-0.012374207,
0.009040909,
-0.04309478,
0.010171849,
0.026229879,
0.04047576,
-0.00625324,
-0.0064119687,
0.0070898714,
0.026719293,
0.013306737,
0.04103131,
-0.009642755,
0.016547443,
-0.021706117,
0.018888688,
-0.011752521,
0.027671663,
-0.007995946,
-0.029682225,
0.020793429,
-0.022235213,
0.00025400688,
-0.0034325032,
-0.0129826665,
-0.0036507547,
0.004722172,
-0.0063755936,
0.020938931,
0.018796096,
-0.005565417,
0.0064384234,
-0.007645421,
-0.018386047,
-0.060951732,
0.023663769,
0.004930503,
-0.038676836,
0.03060814,
0.008313403,
-0.005667929,
0.009027681,
-0.0028323112,
-0.0028471919,
-0.003067097,
-0.005727452,
0.012929756,
-0.022671716,
-0.00078082836,
0.00812822,
-0.0017658542,
-0.019192917,
-0.029470585,
0.083385356,
0.0031745695,
-0.0036540616,
-0.01162686,
0.000137544,
-0.02255267,
-0.007235373,
0.0018948211,
0.011005173,
0.0064384234,
-0.018571232,
-0.021745801,
-0.024404502,
-0.009285616,
0.021917757,
0.050660837,
-0.019140009,
0.030317137,
-0.00038752067,
-0.0037797217,
-0.000018820587,
0.009596459,
-0.009933757,
-0.010780308,
-0.008954931,
-0.049761374,
-0.001206171,
-0.009067364,
-0.025330419,
0.00906075,
0.0026223266,
-0.01117713,
0.016084485,
-0.02088602,
0.010595125,
0.005396768,
0.003726812,
-0.0046097394,
0.022327805,
-0.022473305,
0.01336626,
0.013571284,
0.010105712,
0.022883354,
-0.011342471,
0.018187637,
0.006626914,
-0.013293509,
-0.010555443,
-0.014166516,
-0.0010135474,
-0.029285403,
0.013928424,
0.033147797,
-0.036216546,
-0.01882255,
-0.03740701,
0.014761748,
-0.0067624943,
-0.03412662,
0.003921916,
0.021296069,
0.003521788,
-0.001586458,
0.0072221453,
-0.16539507,
-0.009259161,
0.02009238,
-0.000100135345,
0.027777482,
0.0072618276,
0.010211531,
0.019417783,
0.004040962,
-0.009424503,
0.033941437,
0.0018667129,
-0.035819724,
-0.038782656,
0.0005063604,
-0.0005857246,
0.010846445,
0.04592544,
0.008961544,
0.007903355,
0.03182506,
-0.0127115045,
0.026031468,
-0.023835724,
0.012288229,
0.010290896,
0.0055125076,
-0.021573845,
-0.001211958,
-0.01781727,
-0.0033812472,
0.003730119,
0.019153235,
0.028703399,
0.0070105074,
-0.004672569,
-0.0049635717,
0.012380821,
-0.0036375273,
0.012823937,
0.0033266842,
0.0031365408,
-0.01917969,
-0.00069815724,
-0.009675823,
0.024497094,
0.0051322207,
-0.01037026,
0.021864846,
0.0012169182,
-0.0023412448,
0.007440397,
0.014153289,
0.01722204,
0.03383562,
0.012294843,
0.011970772,
0.02581983,
0.00042410262,
0.0010524028,
-0.012261774,
-0.008399381,
0.016388714,
-0.015476026,
0.033650436,
-0.014854339,
-0.025132008,
-0.011316017,
-0.03187797,
0.0005576164,
-0.013326578,
-0.008174516,
0.0038623929,
-0.020515654,
0.022737853,
0.017751133,
-0.025502374,
-0.0001324804,
0.016626807,
0.02154739,
-0.0132736685,
-0.0007948824,
-0.031745695,
-0.011150675,
-0.016375488,
0.0071163266,
0.0054662116,
0.00861102,
-0.019259054,
-0.0065574697,
0.020819884,
-0.023452131,
-0.0022767615,
-0.011011788,
0.02587274,
0.01555539,
-0.018915143,
-0.001960958,
0.0053405515,
0.0037598806,
0.033438798,
0.0037631874,
-0.0157538,
0.0127578005,
0.018690277,
0.011157288,
-0.033015523,
-0.010026349,
0.051719025,
-0.03185151,
0.015528935,
-0.010304123,
0.011401995,
0.03529063,
-0.010396714,
0.0037367328,
0.011778975,
-0.023028856,
-0.00023065231,
-0.01148136,
0.056666065,
0.012976052,
0.0016087792,
0.020171743,
-0.009556777,
-0.018809324,
-0.12857006,
-0.013968105,
-0.022790764,
0.043914877,
-0.0043815672,
0.018558003,
0.015026295,
0.009603072,
0.010502534,
0.023994453,
0.00039268762,
-0.015198251,
-0.004388181,
-0.016018348,
0.010304123,
0.012513095,
0.009953598,
0.010079258,
-0.017989226,
0.028015574,
0.0050032535,
-0.02230135,
-0.0019311964,
-0.006917916,
0.00028004826,
0.0048809005,
-0.012923143,
0.023941545,
-0.0018336445,
0.021944212,
0.008875567,
-0.0043981015,
0.011243267,
0.0063160704,
0.0062201717,
-0.01998656,
0.023544723,
0.013154622,
0.026534108,
-0.0091004325,
0.0006696357,
0.005585258,
-0.0022850286,
0.0013524988,
0.019417783,
-0.022116167,
0.0025198145,
-0.0087631345,
0.0018452185,
0.0025313883,
-0.02133575,
-0.030026136,
-0.038835566,
-0.012552776,
0.026811885,
-0.029073766,
0.011712838,
0.034364715,
-0.013372874,
-0.0036838232,
-0.008326631,
0.0035482426,
-0.0073478054,
0.0086507015,
0.03433826,
-0.0073411916,
-0.0004112886,
-0.021137342,
0.013379487,
-0.03952339,
0.0063292976,
0.021282842,
0.0013963145,
0.0051355273,
-0.012334525,
0.0076388074,
-0.0021858234,
-0.0024040749,
-0.0044179424,
-0.047592085,
-0.004166622,
-0.018703505,
0.0058035096,
0.0063160704,
-0.0038491653,
-0.0053273244,
0.030422956,
0.00014798123,
-0.014920476,
-0.02361086,
-0.006597152,
0.024893915,
0.02043629,
-0.021018295,
-0.021018295,
-0.0007481733,
0.016349033,
0.00031291004,
0.024087045,
0.014788202,
-0.02386218,
-0.03182506,
-0.052062936,
0.01273796,
0.013002507,
-0.021256387,
0.01049592,
-0.009259161,
0.0010193344,
-0.010436397,
0.015793482,
0.005052856,
-0.02587274,
0.013968105,
0.0063094567,
-0.008405996,
-0.018849006,
-0.004275748,
0.028941492,
0.0022420397,
0.001231799,
0.02481455,
0.007605739,
0.038174197,
0.017843725,
-0.0030737107,
-0.019192917,
0.010403329,
-0.01230807,
0.025277508,
-0.017089766,
-0.0052744146,
-0.010449625,
-0.027671663,
-0.028412396,
0.028147848,
-0.011349086,
0.0024817858,
-0.023187583,
0.0068054833,
0.023835724,
0.026362153,
-0.017089766,
-0.025714012,
0.0016980639,
-0.0038491653,
-0.0076851035,
-0.019087099,
-0.011487973,
0.007017121,
-0.005915942,
-0.007718172,
0.030978506,
0.027301297,
-0.025158463,
-0.020356927,
-0.01331335,
-0.0036309138,
-0.004742013,
-0.020356927,
-0.0065872315,
-0.041004855,
0.023835724,
0.02748648,
0.0101784635,
-0.018835777,
0.0036044589,
-0.01670617,
0.0067922557,
-0.01566121,
0.022909809,
-0.04716881,
-0.015330525,
0.017274948,
0.0011573951,
0.019616194,
-0.0037334259,
-0.009199638,
-0.0073279645,
0.0071758498,
0.0052975626,
0.022036802,
0.003518481,
-0.005337245,
-0.019166462,
0.032380607,
0.027724573,
-0.013425783,
-0.008743294,
0.013478693,
-0.006534322,
-0.002910022,
-0.0057803616,
0.015198251,
0.0030257613,
0.00008706298,
-0.007109713,
-0.002772788,
0.00010788575,
0.014523655,
-0.012334525,
0.034867354,
-0.006825324,
-0.0054364502,
-0.002804203,
0.004913969,
-0.0074073286,
-0.005747293,
-0.015833165,
-0.03534354,
-0.02169289,
0.013809376,
0.008339859,
-0.000046915837,
0.03060814,
-0.0028653794,
-0.0063954345,
0.032142516,
0.002898448,
-0.0046262736,
0.0141268335,
0.006640141,
0.029470585,
0.020105606,
0.0042856685,
0.0010168543,
0.0016732626,
-0.0016352339,
0.021587072,
-0.01611094,
0.020277562,
0.0063292976,
0.020118833,
-0.017288176,
-0.04555507,
-0.016745854,
-0.011818658,
-0.009166569,
0.018994506,
0.0065673906,
-0.007420556,
0.07423201,
0.010052803,
-0.013346419,
0.01268505,
0.017380767,
0.03312134,
0.011944317,
0.014986613,
0.004927196,
-0.0059986133,
0.019960105,
-0.023280175,
0.027301297,
-0.026798656,
-0.026150515,
0.014894022,
-0.011415223,
0.0115012005,
0.0057605207,
-0.011150675,
0.024655823,
-0.01636226,
-0.011421836,
0.01787018,
-0.05158675,
-0.010555443,
0.037116006,
-0.0289944,
0.00091516884,
-0.03568745,
-0.009067364,
0.00040012802,
-0.021031521,
0.013015734,
-0.0043286574,
-0.031692784,
0.0011044856,
-0.0016096059,
0.01751304,
0.024272228,
-0.00505947,
0.007354419,
-0.0043947943,
-0.029338311,
0.0038789269,
-0.0012780948,
0.0098411655,
0.0012160916,
-0.03005259
] |
Despite being surrounded by diverse nutrients, mammalian cells preferentially metabolize glucose and free amino acids. Recently, Ras-induced macropinocytosis of extracellular proteins was shown to reduce a transformed cell's dependence on extracellular glutamine. Here, we demonstrate that protein macropinocytosis can also serve as an essential amino acid source. Lysosomal degradation of extracellular proteins can sustain cell survival and induce activation of mTORC1 but fails to elicit significant cell accumulation. Unlike its growth-promoting activity under amino-acid-replete conditions, we discovered that mTORC1 activation suppresses proliferation when cells rely | [
-0.020038625,
-0.029119903,
-0.0029891403,
-0.031947605,
-0.011603098,
0.017020596,
-0.0036875694,
-0.009373563,
-0.02974526,
-0.009604674,
0.03270891,
0.0076538306,
0.018461637,
-0.010420358,
-0.011861399,
0.0077082096,
0.046004552,
-0.008381149,
-0.025462922,
0.014750278,
-0.022907114,
0.017523602,
-0.0014053548,
-0.04263306,
0.00894533,
0.021166988,
0.00829958,
-0.03262734,
0.0038710982,
-0.02479678,
0.016544782,
-0.015579556,
-0.0016874453,
-0.0032202506,
0.015334851,
0.019454053,
0.022431297,
0.0015056159,
0.014682304,
-0.010712644,
0.020188168,
-0.0052339695,
0.0031182903,
-0.0017265301,
-0.002258424,
-0.0037521443,
-0.01832569,
-0.004214365,
-0.009217224,
0.0036773733,
0.022254566,
0.009672647,
-0.000987317,
-0.0025914947,
-0.022662409,
-0.00476835,
-0.025816385,
0.01536204,
0.0058763204,
-0.012405188,
-0.00037215563,
0.009944542,
-0.030207481,
0.014763872,
0.001845484,
0.03330708,
0.018883074,
0.020528035,
0.0063691293,
0.0006249326,
0.018502422,
0.01610975,
-0.010916565,
0.0030741075,
-0.006447299,
-0.033959627,
-0.034095574,
0.002797115,
-0.009162845,
0.004904297,
0.015565962,
-0.011473949,
-0.01028441,
0.030914407,
0.002892278,
-0.0049314867,
-0.014342436,
0.010318397,
0.008122848,
0.016993407,
0.011405975,
0.01659916,
0.022281757,
0.01268388,
-0.010624278,
0.004962075,
0.00037130594,
0.033497404,
-0.00081780774,
-0.017074976,
-0.026496122,
0.02206424,
-0.015647529,
-0.021588424,
-0.008489907,
0.0037929285,
0.009149251,
-0.014763872,
0.016191319,
-0.01090297,
-0.012541135,
0.03714079,
-0.0015727398,
-0.0564453,
0.01018245,
0.011874993,
0.038255557,
-0.0013050936,
0.0043333187,
-0.008483109,
0.013227669,
0.014464788,
0.040050063,
-0.007946117,
0.014927009,
0.027257426,
0.009258009,
0.0021938488,
-0.028983956,
-0.006287561,
-0.0030758067,
0.019861894,
-0.003956065,
0.029609313,
-0.027175857,
0.027760431,
-0.02033771,
-0.016694324,
-0.011650681,
-0.02871206,
0.010610684,
0.0322195,
-0.0069095194,
0.009543498,
-0.012908192,
0.021479666,
0.029038334,
0.0064167106,
-0.009128858,
0.019182159,
0.019766731,
-0.019209348,
0.009890163,
-0.01757798,
0.009094872,
0.0043910965,
-0.029473366,
0.0283586,
-0.027556509,
-0.007782981,
0.0063181487,
-0.015090146,
0.014519167,
0.0023433908,
0.023682013,
0.022934303,
0.03327989,
0.01706138,
0.006345338,
-0.0034972432,
0.016272888,
0.026659258,
-0.022879925,
0.027406968,
-0.015307661,
0.040920123,
0.009727026,
0.03164852,
-0.03871778,
-0.0058695227,
-0.0038065233,
0.013485968,
0.018556802,
0.0048941015,
-0.004418286,
-0.0004140019,
0.036107592,
-0.01935889,
0.019522026,
-0.029174281,
-0.016354455,
0.020188168,
-0.018257717,
-0.027189452,
-0.62165964,
-0.03164852,
0.014029757,
-0.0073887333,
-0.007381936,
0.040403526,
-0.002453848,
0.0041769794,
-0.014791062,
0.020296926,
-0.013438387,
0.017713929,
0.004353711,
-0.05753288,
0.010794212,
-0.029228661,
-0.018883074,
-0.01734687,
0.010678657,
-0.0034054788,
-0.041871756,
-0.016667133,
-0.01832569,
0.014165704,
0.0017979025,
0.027760431,
0.015049362,
-0.018461637,
-0.004758154,
0.041762996,
-0.02234973,
0.013424791,
0.0026169848,
-0.00494848,
0.05451485,
-0.0051354077,
-0.0027699254,
0.021370908,
0.021330126,
0.022947898,
0.009917352,
-0.007884941,
0.019399675,
0.01350636,
-0.024620049,
0.015416419,
-0.010984538,
0.012881002,
-0.012364403,
-0.0038269153,
-0.0015863345,
0.0017375759,
-0.032980803,
-0.008421932,
0.025449326,
0.01665354,
0.015402825,
-0.021180583,
0.0047105723,
0.00445907,
-0.001683197,
0.034149952,
-0.010155261,
-0.008102457,
-0.015062956,
0.011861399,
-0.02249927,
0.007925726,
0.010128071,
0.020963067,
0.038935296,
0.022336135,
-0.006790566,
0.01740125,
0.0039356733,
0.03724955,
-0.009312388,
0.026278606,
-0.014274462,
0.017781902,
0.008986114,
-0.015933018,
-0.03026186,
-0.015525177,
0.014682304,
0.0075518703,
-0.034639362,
0.016993407,
0.024701618,
-0.001989928,
0.011038917,
0.0067123957,
-0.020310521,
-0.050762706,
-0.023518875,
0.010039705,
-0.017510006,
0.0022686198,
0.012255645,
-0.031077543,
-0.02479678,
-0.0019389478,
0.028630493,
-0.006345338,
0.024089854,
-0.02827703,
-0.03423152,
0.0048397225,
0.038989674,
-0.030207481,
0.007959712,
-0.0013671196,
0.012779042,
-0.027638078,
0.00087006245,
-0.016218508,
0.021765156,
0.007830562,
-0.0013543746,
-0.03765739,
0.001064637,
-0.0017273799,
0.034639362,
0.020786336,
0.0031879633,
0.0190734,
0.01513093,
-0.023804365,
-0.016422428,
-0.0023162013,
-0.006202594,
0.004972271,
0.035618182,
-0.027692456,
0.024891943,
0.021207772,
0.01742844,
0.0067191934,
-0.00009165819,
-0.04075699,
-0.011555517,
-0.005855928,
0.0053733154,
-0.014791062,
-0.0268088,
-0.0032695315,
-0.017265301,
-0.0034972432,
0.006382724,
-0.006872134,
0.002724043,
-0.004248352,
-0.0035482235,
0.009033696,
0.013241263,
-0.011705059,
-0.015076551,
-0.026455337,
-0.009482321,
-0.003296721,
0.0021530648,
-0.0077082096,
-0.010767023,
0.01791785,
-0.016463213,
-0.025299786,
0.0051795905,
0.0043299203,
-0.0027801215,
-0.024688022,
0.001595681,
-0.028005136,
-0.019481242,
0.029500555,
-0.028331408,
0.028249841,
-0.023885934,
0.019046212,
-0.013078126,
-0.0034938445,
0.016436024,
-0.015049362,
0.020310521,
0.007925726,
0.02430737,
0.024987107,
0.032681722,
0.0023111035,
-0.010352383,
0.014070542,
-0.010569899,
0.018312097,
-0.016259292,
0.006946905,
0.017700333,
-0.03852745,
0.004054627,
0.0004371554,
0.008340364,
0.010250423,
0.0038031247,
-0.03262734,
-0.00538691,
-0.030207481,
0.023287766,
-0.008218012,
-0.014831846,
-0.017251708,
-0.00878899,
0.014288057,
-0.00781017,
0.009346374,
-0.011412772,
-0.012717866,
-0.0037521443,
0.018991832,
0.017306086,
-0.0128878,
-0.008381149,
-0.014111325,
0.016952623,
-0.010624278,
0.013853026,
-0.024130639,
-0.010481534,
0.023450902,
-0.004217764,
0.031295057,
-0.03227388,
-0.02332855,
-0.0005340178,
0.0041327965,
0.016408835,
0.017931443,
0.011929372,
-0.0054820734,
-0.0003948843,
-0.009468727,
0.027760431,
-0.00626377,
0.0034428644,
-0.00014274463,
0.0037861313,
0.021166988,
-0.018244123,
-0.011732249,
0.022159403,
0.030669702,
-0.013159695,
0.0036637785,
-0.007789778,
0.028195461,
-0.02056882,
0.010733036,
-0.025721222,
-0.0070148786,
0.013220871,
0.016096156,
0.06449338,
0.016286481,
-0.0053223353,
0.0001315927,
-0.0033137144,
-0.013180086,
-0.0020409082,
0.009570687,
0.035890076,
-0.0028345003,
0.004900899,
0.00732076,
-0.023518875,
-0.007891739,
0.00626377,
-0.032681722,
0.009842581,
0.020704767,
0.0072187996,
0.0005144754,
0.030506564,
0.011630288,
-0.0010094084,
-0.025816385,
0.017781902,
0.020296926,
-0.0040818164,
-0.017795496,
-0.03733112,
0.00639292,
-0.010896172,
0.010264018,
-0.0037521443,
0.006104032,
-0.0036060011,
-0.011569112,
-0.019318106,
-0.023682013,
0.013975378,
-0.020922283,
0.032382637,
-0.0043163253,
0.012833421,
-0.008109254,
-0.021384504,
-0.0012090809,
0.043829396,
-0.0070624603,
0.0053325314,
-0.011902182,
-0.008054875,
-0.038826536,
-0.0206232,
0.006290959,
0.009244414,
-0.012140091,
0.0061516133,
0.0013288845,
-0.002299208,
0.01596021,
0.026428146,
0.013322831,
-0.004557632,
-0.03276329,
0.01116127,
-0.0075586676,
0.020759147,
0.034149952,
0.00768102,
0.004877108,
-0.0033833873,
0.031295057,
0.014573546,
-0.021996267,
0.014559952,
-0.02634658,
-0.017958634,
-0.009604674,
-0.004917892,
-0.016354455,
0.021099014,
0.015756287,
-0.013920999,
-0.01861118,
-0.008129646,
-0.0028548925,
0.047744676,
-0.0053223353,
0.018475233,
0.014274462,
0.02752932,
0.014328841,
0.010393168,
0.019861894,
0.0037215562,
0.00089555257,
0.006328345,
0.012541135,
-0.0009261407,
-0.0014750278,
-0.0071644206,
-0.034014005,
0.018475233,
0.013118911,
0.016898245,
0.009455132,
-0.013363616,
0.018760722,
0.0038914904,
0.00084329786,
-0.01129042,
-0.007884941,
-0.008856964,
0.025204621,
-0.0019168564,
-0.014519167,
0.030669702,
-0.011147675,
0.0015905829,
-0.012840219,
0.005047042,
-0.013329629,
0.015933018,
0.0036229945,
-0.014084136,
-0.0034649558,
-0.004374103,
0.00028655134,
-0.016476808,
-0.015865045,
-0.0035142365,
-0.0025779,
0.0053699166,
-0.016667133,
-0.030370617,
0.0068143564,
0.015715504,
-0.045216057,
-0.0069944863,
0.008061673,
0.014084136,
0.029500555,
-0.005162597,
-0.0070556626,
-0.004578024,
0.03754863,
-0.011378786,
0.00639292,
-0.015022173,
-0.050708327,
0.00016908441,
-0.0006155862,
0.0030690094,
-0.025109459,
-0.00878899,
-0.01659916,
0.016735107,
-0.020990256,
0.01337721,
-0.0073683416,
-0.024008285,
-0.012982964,
0.0032933224,
0.008619056,
0.00055398507,
-0.004363907,
0.010780618,
-0.02108542,
-0.030098723,
-0.023709202,
-0.013350021,
-0.00992415,
0.006239979,
-0.010134868,
-0.011181662,
-0.008435528,
0.010970944,
0.011569112,
-0.022771167,
-0.0031811658,
-0.0021717574,
0.020174574,
-0.0056927917,
0.008489907,
-0.011834209,
-0.007993699,
-0.017972227,
-0.032355446,
0.025109459,
-0.0046358015,
0.00260339,
0.010298005,
-0.0028209055,
-0.024891943,
-0.00969304,
-0.01278584,
-0.029174281,
0.03279048,
-0.0058661243,
-0.03559099,
-0.033007994,
-0.010780618,
-0.013003355,
-0.0034972432,
-0.012649893,
-0.011609896,
-0.033116754,
0.007021676,
-0.004900899,
0.0060734437,
-0.0033052177,
-0.037412684,
-0.0076062493,
0.02283914,
0.010726239,
0.0012235254,
-0.0057879547,
-0.0041905744,
-0.032681722,
-0.004656194,
-0.039941303,
-0.029011145,
-0.015715504,
0.007490694,
0.040811367,
0.014791062,
0.0445907,
0.007137231,
0.014274462,
0.01438322,
0.012316822,
0.0015735895,
-0.009890163,
0.015810667,
-0.0029296635,
0.026332984,
0.012507148,
-0.00195934,
0.016925434,
-0.012751853,
0.017292492,
0.014845441,
0.0037045628,
-0.017387655,
-0.0075518703,
-0.023913123,
-0.030669702,
0.04168143,
-0.008591867,
0.0021258753,
-0.013581132,
-0.037956476,
0.03181166,
0.014206489,
0.008605462,
-0.02041928,
0.022947898,
-0.020487253,
0.011630288,
-0.0031199895,
0.0029500555,
0.016245697,
-0.012717866,
0.007728602,
0.0014350932,
0.00626377,
0.0021139798,
-0.010066895,
0.010896172,
-0.01789066,
0.006059849,
-0.008741409,
-0.0054344917,
-0.02438894,
-0.004003647,
-0.020120194,
-0.022621624,
-0.016259292,
-0.008238404,
-0.04565109,
-0.013988973,
0.0024266585,
-0.03031624,
0.014709493,
0.0037555431,
0.008958925,
0.05416139,
-0.00719161,
0.023464497,
-0.019236537,
0.0014733284,
0.022431297,
-0.0017078375,
-0.010746631,
-0.019807516,
-0.008992911,
0.009754216,
0.038010854,
0.012976166,
-0.005536452,
-0.00391868,
-0.008333567,
0.012670284,
-0.017482817,
-0.026564095,
0.029854018,
0.020663984,
0.010420358,
-0.020799931,
-0.021302935,
-0.031403817,
0.0020426076,
-0.0069299117,
-0.0038880915,
0.024973512,
-0.011929372,
-0.023056654,
0.034014005,
0.022648813,
0.0063181487,
-0.006158411,
-0.0074091256,
0.0015820862,
-0.018883074,
-0.0017401249,
0.010066895,
-0.011630288,
0.014614331,
0.008442325,
0.010855389,
0.012174077,
0.011242839,
0.020228952,
0.0036569813,
-0.0005599328,
0.046765856,
-0.007483897,
-0.0021513654,
0.019725947,
0.007728602,
-0.012337213,
-0.008897748,
-0.00034496616,
-0.0025150243,
-0.029935587,
-0.013723875,
0.020976663,
0.025435733,
-0.01789066,
-0.00045329914,
-0.004452273,
0.0021479668,
-0.034149952,
-0.018461637,
0.020065816,
-0.008877356,
-0.024361748,
0.006923114,
0.025653249,
0.023287766,
-0.010977741,
0.019902678,
-0.021914698,
0.021466073,
-0.01708857,
0.0273254,
0.015266878,
0.00055610924,
-0.020745551,
0.017659549,
-0.021275746,
-0.011725451,
0.0031284862,
-0.010916565,
-0.034503415,
-0.0057675624,
0.0074431123,
0.014655114,
0.009543498,
0.0030826041,
0.011371988,
-0.009523106,
0.022879925,
0.013003355,
-0.0065220697,
0.0058117453,
-0.02750213,
-0.004493057,
0.007375139,
-0.01812177,
-0.029364608,
0.017129354,
-0.009958137,
0.0031029962,
0.00904729,
-0.025598869,
-0.031159112,
0.001301695,
-0.01959,
0.004024039,
0.0074023283,
0.008292783,
-0.005196584,
-0.00066826574,
0.018937454,
0.013499563,
-0.014627925,
0.004642599,
-0.0028905787,
-0.011650681,
-0.0358357,
0.010359181,
0.003002735,
-0.008245201,
0.000035234767,
0.00017004028,
-0.023695607,
0.03164852,
-0.008768599,
-0.021588424,
-0.007341152,
0.022594435,
-0.049947023,
-0.036624193,
-0.0074091256,
-0.007633439,
-0.005315538,
0.0066716117,
-0.006287561,
-0.0014019561,
-0.01275865,
-0.00950951,
-0.0036093998,
-0.008136444,
-0.004319724,
-0.006124424,
0.028576113,
0.005237368,
-0.031512573,
-0.01742844,
0.041409533,
-0.0062059923,
-0.003956065,
0.019331701,
0.011745843,
0.020351306,
-0.009149251,
0.014886225,
0.024470506,
0.014274462,
0.014695899,
-0.018638369,
-0.0026951544,
0.030207481,
0.0070488653,
-0.0038541048,
-0.007830562,
0.023097439,
0.014546357,
-0.00793932,
0.0030503166,
-0.029310228,
0.009761013,
-0.00781017,
0.0056825955,
0.028521735,
-0.0013254858,
-0.010019313,
0.019970652,
-0.015973803,
-0.0010433953,
0.006987689,
-0.016517593,
-0.01760517,
0.01616413,
0.020718362,
0.0016797984,
0.016612755,
0.013519955,
-0.01639524,
0.0040070456,
0.0049688723,
0.010053299,
-0.008863761,
0.0047309645,
-0.0055772364,
-0.01685746,
-0.011773033,
0.008462717,
-0.0074023283,
-0.00018735231,
-0.0049314867,
-0.000048962254,
-0.015715504,
-0.029228661,
-0.010624278,
-0.0073615443,
-0.015769882,
-0.021139799,
-0.015430014,
-0.0056825955,
-0.00006446874,
0.18706343,
-0.024280181,
-0.008809382,
0.021194179,
-0.011854601,
-0.011725451,
0.0060122674,
-0.013812241,
0.0019253531,
-0.0040716203,
0.011915777,
0.027801214,
-0.016871056,
-0.014709493,
0.009325982,
0.002627181,
-0.04312247,
0.007184813,
-0.018488828,
-0.026115468,
-0.010474736,
-0.0056723994,
0.019141374,
-0.007381936,
0.025938736,
-0.014913415,
-0.008564677,
-0.010298005,
0.015008577,
0.008408338,
-0.018271312,
0.008000496,
-0.010665063,
-0.0016143738,
0.0037079614,
0.030941596,
-0.006807559,
-0.008612259,
0.010535913,
-0.006498279,
0.009625066,
0.0015421517,
0.0061754044,
0.010522318,
-0.002722344,
0.0029534542,
-0.012452769,
-0.008455919,
0.0032542376,
0.009523106,
-0.055412102,
0.011195256,
0.0046324027,
0.029636502,
0.013798647,
-0.019005427,
-0.0044760634,
0.008802585,
-0.014220083,
0.022268161,
-0.022716787,
0.0068619377,
-0.03230107,
0.037358306,
-0.03224669,
0.007415923,
-0.0052645574,
0.013098518,
0.015321256,
-0.018638369,
0.007021676,
0.011242839,
-0.027869187,
-0.009094872,
-0.009033696,
-0.0036365893,
0.022417704,
0.034394655,
0.015797071,
0.022037052,
0.0013339825,
-0.0056214193,
-0.020405684,
0.015076551,
-0.007585857,
-0.032491393,
0.0049756696,
-0.0031930613,
-0.013078126,
0.0057029873,
0.017387655,
-0.02879363,
-0.00049068464,
-0.021289341,
0.004010444,
-0.022213781,
0.00920363,
0.011344799,
0.00031331595,
-0.029636502,
-0.03028905,
0.075151645,
-0.00050852774,
0.0036875694,
-0.018488828,
-0.010936957,
-0.017822687,
0.017007003,
-0.007816968,
0.007980105,
-0.007279976,
-0.026999125,
-0.008802585,
-0.02286633,
-0.014070542,
0.01077382,
0.021194179,
-0.018216932,
0.052801915,
-0.019725947,
-0.0073071653,
-0.01116127,
0.023981096,
0.019997843,
-0.0075110863,
0.014478383,
-0.0035550208,
0.0011674471,
-0.0051897867,
-0.04907696,
-0.008795788,
0.0067293895,
0.009849379,
-0.000032659205,
0.002034111,
0.009761013,
0.0013577732,
-0.023926718,
0.003966261,
0.012765448,
-0.01755079,
0.0037011642,
0.02879363,
0.008442325,
-0.005652007,
0.008088862,
0.00683135,
0.015144525,
-0.007884941,
-0.01644962,
0.001915157,
-0.012459566,
-0.016843865,
-0.00051617477,
0.008503501,
-0.028331408,
-0.015280472,
-0.046493962,
0.006889127,
-0.0065186713,
-0.023029465,
-0.00013488517,
0.006736187,
-0.024728807,
-0.010488331,
0.009992124,
-0.1711848,
0.0056078243,
-0.0020562024,
-0.04170862,
0.013832633,
-0.005053839,
0.0036093998,
0.009862973,
-0.016517593,
-0.010189247,
0.049321666,
-0.028603304,
-0.041762996,
-0.012860611,
0.004374103,
-0.0010663363,
0.011874993,
0.025095863,
-0.0014852238,
0.0009193433,
0.012384796,
-0.03811961,
0.023246981,
-0.001162349,
0.007531478,
0.025965927,
0.002842997,
0.009427942,
-0.0006215339,
-0.017387655,
-0.00471737,
0.006634226,
0.032518584,
-0.011507936,
0.024484102,
0.009998921,
-0.007130434,
0.021955483,
-0.0016415631,
0.015280472,
0.025272595,
0.02183313,
-0.011025323,
0.014165704,
-0.002907572,
0.022308946,
0.010882578,
-0.0074567073,
0.026659258,
-0.013261655,
0.020813525,
-0.02258084,
0.0064744884,
0.04877788,
0.0032831263,
0.034965634,
0.0005450635,
0.014111325,
0.006246777,
-0.009890163,
-0.021044636,
-0.00791213,
0.04222522,
-0.014859036,
0.013567536,
-0.039642222,
0.0073479493,
0.005502465,
-0.030533755,
0.002747834,
-0.010998134,
-0.00061388686,
-0.007395531,
-0.0015684915,
-0.0014206489,
0.019766731,
-0.014994983,
-0.004163385,
-0.0024521486,
0.005974882,
-0.025585273,
0.0027155464,
-0.029473366,
-0.019549215,
-0.035455044,
-0.014954198,
0.022472082,
0.01067186,
0.0019423465,
-0.013370413,
0.024144234,
-0.002727442,
-0.013186884,
-0.0188151,
0.023505282,
0.016871056,
-0.008863761,
0.018053796,
-0.011453557,
-0.0042823385,
0.026591284,
-0.015538772,
-0.01693903,
0.0040954114,
0.023749987,
0.005281551,
-0.014818251,
0.0047411607,
0.055357724,
-0.024008285,
-0.002683259,
-0.0050640353,
0.012344011,
0.030914407,
0.0071984073,
0.030125912,
0.008489907,
-0.022240972,
0.016232103,
-0.0065254685,
0.047799055,
0.022200188,
-0.023219792,
0.001311891,
0.010970944,
-0.027148668,
-0.13899247,
-0.021003852,
-0.0021462673,
0.011066107,
-0.021248557,
0.005053839,
-0.008211214,
0.015810667,
-0.01327525,
0.044454753,
-0.018828696,
-0.0016738506,
0.013268452,
-0.010467939,
0.024701618,
-0.01129042,
0.030098723,
-0.0031556757,
-0.044427563,
0.021615615,
0.004958676,
0.017591575,
-0.007789778,
0.0128878,
-0.003521034,
0.022363324,
-0.029201472,
0.03966941,
0.0060224636,
-0.0030809047,
0.036542624,
0.003470054,
0.041355155,
-0.007178015,
0.0018964643,
-0.008313175,
0.0049450817,
-0.023749987,
0.019494837,
-0.009944542,
-0.009584282,
0.04108326,
0.02822265,
-0.009563889,
0.008619056,
-0.03436747,
-0.0032100547,
0.016055372,
0.02105823,
-0.024157828,
-0.035020012,
-0.013098518,
-0.035971645,
-0.011467151,
0.016612755,
-0.02005222,
0.0011903882,
0.02361404,
-0.0059918757,
-0.012459566,
-0.01229643,
0.0031063948,
-0.012405188,
0.0020018234,
0.035074394,
-0.01901902,
-0.005648609,
-0.031458195,
0.02933742,
-0.022852734,
0.008578272,
-0.01265669,
-0.0027053505,
-0.01487263,
-0.030017154,
-0.008333567,
0.0028786832,
-0.012248848,
-0.0014690801,
-0.0036093998,
-0.0066512194,
-0.029935587,
0.027515726,
-0.02234973,
-0.009312388,
0.004656194,
0.008673435,
0.0038133205,
0.008285985,
-0.021955483,
-0.004972271,
0.031566955,
0.023682013,
-0.013526753,
-0.014981388,
0.007082852,
-0.0069537023,
0.006967297,
0.024076259,
0.011072904,
-0.00409881,
-0.016585566,
-0.041926134,
0.009054087,
0.017074976,
0.01536204,
0.01901902,
-0.026686447,
-0.0013501262,
-0.015865045,
0.009346374,
0.024755996,
-0.018013012,
-0.0036433865,
0.0034496617,
-0.014315247,
-0.022512866,
-0.01466871,
0.025150243,
-0.014954198,
0.0008717618,
0.040131632,
-0.00029887154,
0.0016721513,
0.001750321,
0.003072408,
0.0003162898,
-0.0037827324,
-0.026197037,
0.023151819,
-0.0044352794,
-0.021207772,
0.007429518,
-0.04877788,
-0.0077421963,
-0.01002611,
-0.029119903,
-0.026251417,
-0.012065319,
0.014886225,
0.0063725277,
0.02678161,
-0.019834705,
-0.027121479,
0.01567472,
0.00008464841,
0.0011207152,
0.006345338,
-0.028113892,
0.005057238,
-0.012187672,
-0.026455337,
0.038935296,
0.017387655,
-0.007891739,
-0.017999416,
-0.0062569724,
-0.006124424,
0.014709493,
-0.0141793,
-0.004207568,
-0.008143241,
0.0043707043,
0.0044794623,
0.013098518,
0.009156048,
-0.012439175,
0.0065764487,
-0.032437015,
0.013914202,
0.023777176,
-0.027841998,
-0.025136648,
0.0037555431,
0.027067099,
0.0072120023,
0.010726239,
-0.012806232,
-0.02646893,
0.009380361,
-0.014002568,
0.017414844,
0.010420358,
0.0010807808,
-0.021221368,
0.014451194,
0.032083552,
-0.007769386,
0.011215649,
0.010875781,
0.0010238528,
-0.0047649513,
-0.0014631323,
0.01760517,
0.011038917,
0.0051931855,
0.0033595967,
0.014437599,
-0.012425579,
0.00943474,
0.010427155,
0.011229244,
0.0068551404,
-0.01886948,
0.004561031,
-0.020990256,
-0.01910059,
0.009251211,
-0.04317685,
-0.045705467,
-0.006889127,
0.0055296547,
0.0055670403,
0.001224375,
-0.00081610837,
-0.009346374,
-0.014070542,
0.033361457,
0.02634658,
0.0075518703,
0.0014622827,
0.022200188,
0.01582426,
0.01438322,
0.0055534453,
0.014573546,
0.0043876977,
0.012242051,
0.010753429,
-0.013696686,
0.038962483,
-0.023586849,
0.01959,
-0.022934303,
-0.042823385,
-0.0072120023,
-0.0005497367,
-0.014927009,
0.0032576362,
0.0342859,
-0.013397602,
0.08271031,
-0.0030384213,
-0.01167787,
-0.0019066603,
0.015742693,
0.038826536,
0.031512573,
0.02974526,
-0.003911882,
-0.03132225,
-0.00708965,
-0.0057369745,
0.033443026,
-0.05204061,
-0.0028378991,
0.02709429,
0.00096777454,
0.00793932,
-0.0021853521,
-0.008381149,
0.017047787,
-0.016721513,
-0.0042347573,
0.02646893,
-0.027189452,
0.017034192,
0.048832256,
0.0066104354,
0.027869187,
-0.020881498,
-0.0002752932,
0.012738259,
-0.03175728,
-0.017741118,
0.002443652,
-0.0062195873,
-0.027338995,
-0.013485968,
0.006940108,
0.0064676907,
-0.026591284,
-0.006338541,
-0.006148215,
-0.010440749,
-0.0037725365,
-0.01020964,
-0.016204914,
0.0003052441,
-0.0066954023
] |
We developed a general model of sporophytic self-incompatibility under negative frequency-dependent selection allowing complex patterns of dominance among alleles. We used this model deterministically to investigate the effects on equilibrium allelic frequencies of the number of dominance classes, the number of alleles per dominance class, the asymmetry in dominance expression between pollen and pistil, and whether selection acts on male fitness only or both on male and on female fitnesses. We show that the so-called "recessive effect" occurs under a wide variety of situations. We found emerging properties of finite population models with several alleles per dominance class such as that higher numbers of alleles are maintained | [
-0.028461173,
0.016617738,
-0.003584024,
-0.025282701,
-0.019809399,
0.040172722,
-0.017751964,
0.0070097838,
-0.02670708,
-0.027537966,
0.0038642834,
0.014929587,
0.02550691,
0.018055305,
0.013426078,
0.00790002,
0.051224835,
0.008922143,
0.0045566894,
0.007286746,
-0.010135502,
0.02479472,
-0.009238671,
-0.01609019,
-0.019941285,
0.009924483,
0.0054370337,
-0.038009778,
-0.016380342,
0.0036104014,
0.022011908,
0.012318228,
-0.017079342,
-0.023713248,
-0.027063174,
-0.019848965,
0.0024465004,
-0.002944373,
0.006528397,
-0.020020418,
0.010511379,
0.0077813216,
-0.015931927,
-0.0017343116,
-0.0007319718,
0.0051831515,
0.0053710905,
0.008269303,
-0.00414784,
0.006584449,
0.0033763023,
0.00532493,
-0.02189321,
-0.00030375182,
0.0035675382,
-0.006330567,
0.013742605,
0.01949287,
-0.014533927,
0.010122312,
-0.009258454,
0.015813228,
-0.02198553,
0.012166558,
-0.04259944,
-0.0013345296,
0.010972982,
-0.012107209,
-0.010326738,
0.000048736296,
0.044287592,
0.014890021,
-0.025678363,
-0.011711549,
0.0077879163,
-0.019914908,
-0.0088562,
0.016921077,
-0.012885341,
0.009680492,
0.019479683,
-0.0050809393,
-0.013135926,
0.026548814,
0.009436501,
0.00041544344,
0.01420421,
0.025229948,
0.003386194,
0.0006800414,
0.007965963,
0.00274984,
0.01244352,
-0.0034686232,
-0.01610338,
-0.015575833,
0.006314081,
0.0062646233,
-0.00515018,
-0.0075834915,
0.0060272273,
0.008783662,
-0.018741116,
-0.0054897885,
-0.029463513,
-0.010386086,
0.0047380337,
-0.016670493,
-0.015325247,
-0.017883852,
-0.01970389,
-0.00017907756,
0.0083418405,
-0.04011997,
0.012773237,
-0.012206124,
-0.004840246,
-0.016841946,
-0.014758134,
-0.011619228,
0.033446494,
0.0077021895,
0.027722608,
-0.0056645386,
0.015404379,
0.00984535,
-0.0182927,
0.0016279778,
-0.023647305,
-0.009522228,
0.0028289722,
0.03030759,
0.0043225903,
0.017817909,
-0.026562003,
-0.000009176694,
-0.030386722,
-0.014520737,
-0.009515633,
-0.024425438,
-0.012957879,
0.03059774,
-0.043443516,
0.00038782964,
0.016459474,
0.032444157,
0.038036156,
0.011797275,
0.006116251,
-0.0032872788,
-0.021761324,
-0.0014441606,
0.006449265,
0.012074238,
0.027854495,
-0.0125292465,
0.017646454,
0.01598468,
-0.028355664,
0.001704637,
0.015760474,
-0.0046226326,
-0.010306954,
0.010372898,
0.009067218,
0.0060470104,
0.011592851,
0.0049028923,
-0.0005815384,
0.005384279,
-0.00222559,
0.0023937456,
-0.02319889,
0.005733779,
0.0054963827,
0.011170813,
-0.00884301,
-0.0046358216,
-0.020706229,
-0.0125754075,
-0.006004147,
0.021695381,
0.032338645,
0.0128128035,
-0.0018678469,
-0.0012273716,
0.02020506,
-0.009185917,
0.007161454,
0.008420973,
-0.0035279721,
0.020363323,
-0.007979152,
0.0023657198,
-0.63221264,
0.004899595,
0.034026798,
-0.025454154,
0.012938096,
0.03088789,
0.006238246,
0.0056513497,
-0.002805892,
0.01610338,
-0.018042115,
0.033024456,
0.029648155,
-0.010003614,
-0.003682939,
-0.045632835,
0.030360343,
-0.032813437,
0.019888531,
0.010728992,
-0.006043713,
0.014032757,
-0.017184852,
0.016024247,
0.014731756,
0.009700275,
0.0032196867,
-0.0058195055,
-0.0139008695,
0.0021464578,
-0.016630927,
0.03149457,
-0.029067853,
0.022407569,
0.04708359,
0.0125754075,
0.002941076,
0.023067003,
0.024399059,
0.052649215,
-0.008269303,
0.0013485426,
0.029278873,
-0.008084661,
-0.0007068309,
0.008783662,
-0.009245265,
0.028223777,
0.010722398,
-0.036954682,
0.012634756,
0.0069504348,
-0.004787491,
0.0034917032,
0.0070757275,
0.0038247176,
0.029832797,
-0.025638796,
-0.0042500524,
-0.0019848964,
-0.027247814,
-0.004230269,
-0.007860454,
-0.020547966,
0.0034521373,
0.004454477,
-0.01660455,
0.013320568,
-0.013755795,
-0.020046795,
0.0036268872,
0.028935965,
-0.012423738,
0.0062679206,
-0.004840246,
0.014467983,
0.011216973,
0.0048897034,
-0.015351624,
0.0010278928,
-0.00569751,
0.019321417,
0.001239736,
0.0041676234,
0.032127626,
-0.009766218,
0.0051798546,
0.0318111,
-0.022618588,
0.003580727,
0.031758342,
0.010353114,
0.0030333966,
-0.030544985,
-0.02199872,
0.010155285,
-0.020271003,
0.0009767867,
0.0054897885,
-0.023752814,
-0.031257175,
-0.014349285,
0.008579237,
-0.007102105,
0.005404062,
0.014428417,
-0.011691766,
-0.0004218317,
0.031178042,
0.0039467127,
0.01630121,
-0.017224418,
-0.027142305,
0.0091925105,
0.01359753,
-0.028434796,
0.017158475,
0.01839821,
-0.01769921,
-0.008869388,
0.016169323,
0.009416718,
0.008533076,
-0.020534776,
0.004296213,
0.016353965,
-0.011230161,
0.010280577,
0.000058524773,
-0.011401615,
0.007998935,
-0.023937456,
0.015483512,
-0.018437777,
0.006178897,
-0.013861304,
0.022420758,
0.0071218875,
0.015654964,
-0.045448195,
-0.013927247,
0.0062975953,
-0.0037126136,
-0.0017771748,
-0.025440965,
-0.00042018315,
-0.035662193,
-0.019558813,
0.018714739,
-0.0124105485,
0.025256325,
0.013037011,
-0.027247814,
0.020798549,
-0.022249306,
0.0034554345,
0.001191927,
-0.03030759,
-0.020271003,
-0.005519463,
0.014744945,
-0.0027234626,
-0.020059984,
0.005829397,
-0.008394595,
-0.018741116,
-0.022684531,
-0.0048534344,
-0.0036631562,
-0.01569453,
0.0011391724,
-0.02049521,
-0.016169323,
0.024029776,
-0.010247605,
0.014850454,
-0.0045204205,
0.020455644,
-0.006818548,
-0.009304615,
0.00774835,
-0.02420123,
-0.030228456,
0.00534801,
0.036532648,
0.018015739,
0.029146984,
0.02031057,
0.014283341,
0.018727927,
0.002101946,
0.004157732,
-0.006643798,
0.01368985,
-0.008282492,
0.0048435433,
0.013175492,
0.006581152,
-0.02110189,
0.018543286,
0.020007228,
-0.016512228,
0.0068910858,
-0.016393531,
0.036374383,
-0.026562003,
0.007102105,
-0.019374173,
0.017132096,
0.021629436,
0.00030354573,
0.0031487977,
-0.021022758,
-0.025757493,
-0.004223675,
0.022249306,
-0.0013773929,
0.011915973,
0.017303549,
0.03439608,
-0.021062324,
0.0064195907,
0.023172513,
0.0059151235,
-0.010260793,
-0.0101157185,
-0.014731756,
-0.000028618408,
0.01204786,
-0.009284832,
-0.0030713142,
0.014955964,
-0.0024926607,
0.011434587,
0.014059134,
0.023607738,
0.015747285,
-0.0031207716,
0.05299212,
-0.010583917,
-0.0060107415,
0.013914058,
0.015074662,
0.011981917,
0.01139502,
-0.009423313,
0.027274191,
0.002527281,
-0.017316738,
0.01789704,
0.004787491,
0.027722608,
0.015246116,
-0.0025767386,
0.015668154,
-0.0022453729,
0.018332267,
-0.0010600402,
0.013063389,
0.024240796,
-0.0048897034,
-0.011038926,
0.0099970205,
-0.032760683,
-0.012265474,
0.0071548596,
0.007365878,
-0.001059216,
-0.006818548,
0.0030136136,
-0.030333966,
-0.0024514461,
0.012601784,
-0.0041610287,
0.004207189,
0.025678363,
-0.018965323,
0.0009907996,
0.04919378,
-0.00041832848,
-0.042282913,
-0.015285681,
0.025229948,
0.029542645,
-0.004803977,
-0.017831096,
0.016749624,
0.006798765,
0.012588596,
0.01529887,
0.023924267,
0.020178681,
-0.007181237,
0.005265581,
-0.0025717928,
0.0035147835,
0.015589021,
-0.0072537744,
-0.00009082674,
-0.018886192,
0.011414804,
0.004259944,
-0.014652625,
-0.0022222928,
0.048587102,
-0.0061887885,
-0.0155098885,
-0.0273797,
-0.025757493,
-0.023779191,
0.012436926,
-0.00078678725,
-0.018305888,
0.009185917,
0.0016403422,
-0.016261643,
-0.0054337364,
0.00091826194,
0.03779876,
-0.02319889,
-0.007669218,
0.007761539,
0.015008719,
-0.0020096253,
0.04782216,
0.012265474,
-0.010788341,
0.016868323,
-0.01768602,
-0.0068251425,
-0.005648053,
-0.021352474,
0.022684531,
-0.016868323,
-0.018160814,
-0.006772388,
0.0051007224,
0.017831096,
0.0046753874,
0.0129776625,
-0.0044248025,
-0.03608423,
-0.027722608,
0.02570474,
0.0053941705,
-0.013663474,
0.02809189,
0.026060835,
-0.004728142,
0.016670493,
-0.00090342463,
0.026865343,
-0.016235266,
0.0015579129,
-0.009779407,
0.032576043,
0.020139115,
0.022948304,
0.009964049,
-0.00017444091,
0.0016444636,
0.013313973,
-0.00637343,
-0.019136775,
0.028065514,
0.004203892,
0.016855134,
0.012384172,
0.0030300994,
-0.0065020197,
0.00034022675,
0.008513293,
-0.00311088,
-0.021457983,
0.0073460955,
-0.034738984,
-0.0053348215,
-0.010768558,
0.021708569,
0.0046556043,
-0.020165494,
-0.01134886,
-0.016762814,
-0.016630927,
-0.031652834,
-0.008566048,
0.015681341,
0.0038477976,
-0.0022041583,
-0.00964752,
0.0035939156,
-0.008473728,
-0.026522437,
-0.02669389,
0.01104552,
-0.025665173,
-0.012094021,
-0.020904059,
0.023423098,
0.017118908,
-0.000690345,
-0.0077153784,
0.004062114,
-0.0015340084,
0.013518398,
-0.017514568,
-0.018305888,
-0.05739714,
0.01578685,
0.01598468,
-0.004919378,
-0.013030417,
-0.018266324,
0.0014103645,
-0.002014571,
-0.003874175,
-0.0020673256,
0.002284939,
-0.017316738,
0.007319718,
0.008961708,
0.022882361,
0.004184109,
-0.010972982,
0.030465852,
-0.017250795,
-0.02838204,
-0.034844495,
-0.007708784,
-0.012377577,
-0.0032130925,
0.014243775,
0.007108699,
-0.016644115,
-0.011401615,
-0.012608379,
0.015153795,
-0.0069636237,
0.023528608,
0.009983831,
0.0039401185,
0.006713039,
-0.012667728,
0.004573175,
0.00395001,
-0.025744306,
0.017870663,
-0.0122918505,
-0.02930525,
0.022328436,
-0.027986381,
-0.016987022,
-0.031916607,
0.014810889,
-0.0021612952,
0.031863853,
0.010452029,
-0.03196936,
-0.017356304,
0.004421505,
-0.031731967,
0.0021563494,
0.0023261537,
-0.009627737,
-0.015193361,
-0.0059085293,
-0.0071218875,
-0.02409572,
0.028171023,
-0.035846833,
0.006274515,
0.031125287,
-0.034818117,
0.031336308,
-0.015285681,
-0.013426078,
0.012384172,
-0.0016881512,
-0.013729417,
-0.055761743,
0.012278662,
-0.0035345666,
0.03196936,
0.034026798,
0.03869559,
0.0068910858,
0.01769921,
0.031758342,
0.006798765,
-0.0039236327,
0.0047380337,
0.0061294395,
-0.004164326,
0.009851945,
0.02479472,
0.017422248,
0.017263984,
-0.024926607,
0.03421144,
0.054337367,
-0.031046156,
-0.0267994,
-0.010755369,
-0.03231227,
0.0009743138,
-0.00875069,
-0.0020392998,
0.015483512,
-0.03647989,
0.0052260146,
0.005578812,
0.009838756,
-0.011691766,
-0.017540947,
0.026153155,
-0.0020046795,
0.039777063,
-0.020824928,
0.005737076,
-0.019229097,
-0.031046156,
-0.007148265,
-0.005575515,
0.011302699,
-0.026166342,
0.036427137,
0.03231227,
-0.013808549,
-0.0073922556,
0.0026443305,
-0.0115598785,
-0.010181662,
-0.0036104014,
-0.024214419,
-0.0020854601,
-0.008420973,
-0.012872153,
-0.015285681,
0.016261643,
-0.0068778973,
-0.017554134,
0.0093573695,
0.01169836,
-0.01750138,
0.012318228,
0.004236864,
0.0424148,
-0.0062283548,
0.005153477,
0.014375662,
-0.030729627,
-0.027960004,
0.011309294,
0.013010634,
0.024319928,
0.030782381,
-0.0066899583,
-0.030439476,
-0.025164003,
0.019084021,
-0.014177832,
-0.025968513,
-0.038379062,
0.00879685,
0.016551794,
0.01959838,
-0.009495851,
0.0077219727,
-0.009482661,
0.0017755262,
-0.01880706,
0.0034917032,
0.0011218622,
-0.010016804,
-0.033842154,
0.011335671,
0.014837266,
0.0024432032,
-0.0047973827,
-0.025282701,
-0.0081044445,
-0.012324822,
-0.013927247,
0.028223777,
0.012311634,
0.023409909,
0.0012677619,
0.020666663,
0.0033235475,
0.0032707928,
-0.025414588,
0.001998085,
-0.022882361,
0.038431816,
-0.025071682,
0.0031636348,
-0.016222078,
0.011737926,
-0.013874493,
0.004414911,
-0.02218336,
-0.013267813,
-0.0066339066,
0.011032332,
0.050934687,
-0.0098321615,
-0.011639011,
0.0008671558,
-0.009706869,
0.0008803445,
-0.02948989,
-0.023660494,
0.013953624,
-0.028540306,
-0.003943416,
-0.0013056794,
0.013459049,
0.031151665,
0.012278662,
-0.015483512,
-0.0017672833,
0.012885341,
-0.024293551,
0.021563493,
0.020693041,
0.008275897,
-0.03647989,
0.03218038,
-0.0140987,
-0.010860879,
0.0055425433,
-0.0125292465,
-0.004157732,
-0.0076955953,
0.00028953276,
-0.007616463,
-0.0056513497,
0.009495851,
-0.00774835,
0.008480322,
0.026153155,
-0.007675812,
-0.018820249,
-0.005793128,
0.0027350027,
-0.009739841,
0.030413099,
-0.018556474,
-0.007431822,
-0.010616888,
0.008500105,
0.013320568,
-0.013834926,
-0.009139756,
-0.015285681,
-0.018516907,
0.022605399,
0.010986172,
0.0013419483,
-0.007728567,
-0.008467133,
0.036928307,
-0.00011447363,
-0.017316738,
-0.009654114,
-0.010616888,
0.0037521797,
0.011111463,
0.0013304082,
-0.0017392572,
0.014454794,
-0.01800255,
-0.044656873,
0.0022717502,
0.00639651,
0.037640497,
0.031441815,
0.0070757275,
-0.022618588,
0.016340775,
-0.033921286,
-0.021721758,
0.013445861,
0.005242501,
-0.008744095,
0.03210125,
0.0003490879,
0.01224569,
0.0011276322,
-0.008183576,
-0.0032262811,
-0.035820458,
-0.005110614,
-0.0007150738,
0.021589871,
-0.0019041158,
-0.008968303,
0.0021134862,
0.01709253,
-0.010122312,
-0.0073922556,
0.026786212,
-0.010353114,
0.03218038,
0.012179747,
0.010504784,
0.008981491,
0.018015739,
0.007768133,
-0.021642625,
-0.019888531,
-0.015562643,
0.010405869,
-0.0057041044,
-0.004243458,
-0.0034521373,
-0.014375662,
-0.0048138686,
-0.052227177,
-0.026179532,
-0.0062052743,
-0.0053776847,
0.011223568,
0.013406294,
-0.015338436,
0.0114411805,
0.010333331,
-0.007108699,
-0.006798765,
-0.030175703,
0.019215908,
0.03447521,
0.015720908,
0.010465219,
0.0027679745,
-0.011883002,
0.016841946,
-0.009535416,
0.0052787694,
-0.016973833,
-0.016037436,
-0.025849815,
0.032839816,
0.0025206867,
0.00069323,
0.010821313,
-0.018780682,
-0.011981917,
-0.03690193,
-0.0006557247,
0.015378002,
0.0054963827,
0.010722398,
-0.012225907,
-0.025546474,
0.00427643,
0.0056513497,
-0.011263134,
-0.031758342,
0.0233044,
0.1977247,
-0.008091256,
-0.001563683,
0.028461173,
0.0019815993,
-0.02699723,
-0.0039697927,
-0.01368985,
-0.010425652,
0.0036136985,
0.008130821,
0.009047436,
-0.018279511,
0.013360133,
0.030439476,
-0.014362474,
-0.028751325,
-0.0055689206,
-0.015575833,
0.0070823217,
0.030756004,
-0.019756645,
-0.008361624,
-0.0003400207,
0.04629227,
0.009304615,
-0.023080193,
-0.010867473,
-0.002110189,
-0.01139502,
-0.01459987,
-0.00207392,
0.016947456,
-0.012957879,
-0.02859306,
-0.002360774,
0.020732606,
-0.010808124,
0.00934418,
0.009588171,
-0.01680238,
0.0008333598,
0.03268155,
-0.016393531,
0.0042104865,
0.017132096,
-0.0053150384,
-0.012080831,
-0.023370342,
-0.0047743027,
-0.04191363,
-0.00074392406,
0.004513826,
0.025823437,
-0.0014400391,
0.014441606,
0.019637946,
-0.011236756,
-0.003936821,
0.021154644,
-0.030729627,
0.014916399,
-0.015628587,
-0.0034059768,
-0.020745795,
0.028645815,
-0.015681341,
0.014032757,
0.0077153784,
-0.017184852,
0.01560221,
-0.041043174,
-0.004751222,
0.0018579555,
0.00080492167,
-0.019163154,
0.022658154,
0.01370304,
0.02999106,
0.020112738,
0.007570303,
0.0013930544,
-0.038959365,
-0.0008514942,
-0.010511379,
-0.024623267,
0.030439476,
-0.0022453729,
-0.03431695,
0.00025264567,
0.0037620713,
-0.0129315015,
-0.0023393424,
-0.014428417,
-0.008757284,
-0.014850454,
0.001518347,
0.0047710054,
-0.0045929584,
-0.010986172,
-0.01961157,
0.06467729,
-0.009080407,
0.03558306,
-0.015364814,
0.011612633,
-0.0041313544,
0.016776003,
0.011335671,
-0.026377361,
-0.0017672833,
-0.006643798,
0.022262493,
-0.0075439257,
0.009937671,
-0.0009537065,
0.021642625,
-0.03410593,
0.018424587,
-0.0023426395,
-0.014652625,
-0.021141456,
0.015813228,
0.03260242,
-0.007102105,
-0.001760689,
-0.05887427,
0.019004889,
-0.008546265,
-0.01194235,
0.0203897,
-0.0106828315,
0.0015768717,
0.006192086,
0.021669002,
-0.031072533,
-0.0061360337,
-0.022750475,
-0.009324398,
-0.009627737,
0.01324803,
-0.006581152,
-0.0013823386,
0.01370304,
-0.0018810356,
-0.023726437,
0.0044281,
0.008111039,
-0.018371833,
-0.008895765,
0.011315889,
-0.023172513,
-0.025638796,
-0.00774835,
0.005885449,
-0.012984256,
-0.005559029,
-0.0071350764,
0.0074581993,
0.017949795,
-0.0028190806,
0.023752814,
-0.004362156,
-0.0048864065,
0.015048285,
-0.0025091465,
-0.16491127,
0.013043606,
0.013149115,
-0.026232287,
0.01929504,
0.007379067,
0.033261854,
-0.019532437,
-0.008724312,
-0.013637096,
0.025282701,
0.025045305,
-0.004566581,
-0.02558604,
0.013419483,
0.022117417,
-0.030518608,
0.030518608,
0.02249989,
0.026931286,
0.021246966,
-0.035952345,
0.0071416707,
-0.024583701,
-0.0037620713,
0.019980852,
0.0024910122,
0.00033816602,
-0.006858114,
-0.020007228,
-0.014125077,
0.0056612412,
0.0051040193,
-0.008157199,
0.0006957029,
-0.011731332,
-0.021972343,
-0.005404062,
0.006831737,
0.021866834,
0.03160008,
0.013320568,
-0.017870663,
0.005575515,
-0.013406294,
0.043364383,
-0.00240034,
-0.005766751,
0.026205909,
-0.0070031895,
0.010570728,
0.0044281,
0.032866195,
0.0161957,
0.018820249,
-0.019031266,
-0.004480854,
0.017923417,
0.0006116251,
-0.02550691,
0.0014103645,
-0.01800255,
0.023185702,
0.01970389,
-0.0023739627,
-0.0033565194,
-0.020943625,
0.015536266,
-0.030413099,
0.0045566894,
-0.0032097953,
0.004517123,
0.01849053,
0.0030103165,
0.019651135,
0.007108699,
-0.002273399,
0.009245265,
0.014322908,
-0.021695381,
-0.021695381,
0.029067853,
-0.012483086,
-0.016182512,
0.01459987,
-0.0006297595,
-0.006004147,
0.012126992,
-0.009238671,
0.00774835,
0.015285681,
-0.017316738,
0.006215166,
-0.019954475,
-0.00044511797,
0.015364814,
-0.008974898,
-0.0041511375,
0.016248455,
0.0074450104,
0.0022453729,
-0.016340775,
-0.019136775,
0.019189531,
0.027986381,
-0.0161957,
0.0017656346,
-0.003135609,
0.040436495,
-0.031942986,
-0.0026773023,
-0.0017936606,
0.0026196018,
0.0014647678,
0.0049094865,
0.04558008,
0.016617738,
-0.010550945,
-0.014758134,
-0.024478192,
0.08614846,
-0.005845883,
0.0034125713,
0.010095935,
0.019229097,
-0.020046795,
-0.13610719,
-0.028777702,
-0.011269728,
0.035029136,
0.0075307367,
0.039777063,
-0.014138266,
0.021932777,
-0.043865554,
0.03439608,
-0.010135502,
-0.011948945,
-0.014955964,
-0.013505209,
0.0056612412,
0.00069240574,
-0.0044083167,
-0.001442512,
-0.013557964,
0.02948989,
-0.018266324,
-0.025269512,
-0.0049028923,
-0.010326738,
-0.00012755928,
-0.0066372035,
-0.010478407,
0.015839607,
-0.0015669802,
0.019572003,
-0.0071416707,
0.00042100743,
-0.001563683,
0.0019898422,
-0.011032332,
-0.00088116876,
0.00007506214,
-0.016037436,
0.012298445,
-0.0015307113,
-0.0026888424,
0.005146883,
0.008829822,
-0.0018167408,
0.012041266,
-0.0026327905,
0.0055920007,
0.011474152,
0.010893851,
-0.015443945,
-0.024135286,
-0.016169323,
-0.040357362,
-0.011480747,
0.008031907,
0.0017475003,
0.011704954,
0.021629436,
-0.014059134,
-0.000825529,
-0.00045006373,
0.021642625,
-0.007814294,
-0.022381192,
0.0012232502,
-0.02060072,
-0.026456494,
-0.022354815,
0.009746435,
-0.03328823,
-0.03149457,
0.008981491,
-0.012344605,
0.0037917458,
-0.01949287,
0.010715803,
-0.043179743,
-0.033631135,
0.0015488457,
-0.02848755,
-0.0014202561,
-0.011052115,
0.026008079,
-0.03342012,
-0.0018975214,
0.001078999,
0.0029361302,
-0.0045072315,
-0.01660455,
-0.0054831943,
-0.028804079,
0.006337161,
0.017250795,
-0.025572853,
-0.030149324,
0.03228589,
-0.01459987,
-0.023528608,
0.02629823,
0.010755369,
-0.027142305,
-0.00093722064,
-0.027036795,
0.0393814,
-0.00240034,
-0.015338436,
-0.0070163785,
0.009871728,
0.023067003,
-0.00009463909,
0.0071350764,
0.029806418,
-0.019664323,
0.006660284,
-0.009555199,
-0.015272493,
-0.023568172,
-0.029146984,
0.034659855,
-0.0016996913,
0.03418506,
0.04871899,
-0.019558813,
0.015246116,
-0.000058164143,
0.02420123,
-0.014771323,
-0.03608423,
-0.009726652,
-0.0011787383,
-0.012654539,
-0.0033284933,
0.0032196867,
-0.010181662,
-0.03199574,
0.0082231425,
-0.011480747,
-0.018661983,
0.021022758,
0.017817909,
0.02948989,
0.020323757,
-0.032523286,
-0.02999106,
-0.0068778973,
-0.016736437,
-0.02730057,
0.022117417,
-0.038537327,
0.010095935,
0.017263984,
0.0045566894,
0.04478876,
0.0066339066,
0.00554584,
-0.015087851,
-0.01254903,
-0.00048839336,
0.01779153,
0.012601784,
0.0034686232,
-0.030017437,
-0.0048303544,
0.0059810667,
0.027643476,
0.0070163785,
-0.0027762174,
-0.017290361,
-0.030254833,
0.014138266,
-0.005456817,
-0.021708569,
-0.022710908,
0.01609019,
0.0025602528,
0.0019387361,
0.011639011,
0.0007459848,
-0.010056369,
0.0029394273,
-0.0020854601,
0.027326947,
-0.0039038495,
-0.0029064557,
-0.0025124438,
0.022671342,
0.018174002,
-0.01224569,
-0.022328436,
0.02198553,
0.0033317904,
0.010676237,
0.0028998612,
0.018226758,
-0.0205084,
0.024359494,
0.018833436,
-0.0050776424,
-0.0010699318,
-0.006004147,
0.00884301,
0.0017112313,
0.0071548596,
-0.0029789933,
0.021484362,
0.0012183044,
-0.00039174504,
0.018345455,
-0.017237606,
-0.017329928,
-0.02020506,
0.023489041,
-0.0036895336,
0.011718143,
-0.022038287,
-0.0011490638,
-0.010893851,
0.01961157,
-0.0134524545,
0.01779153,
-0.019215908,
0.0035048919,
0.019558813,
-0.0050051045,
-0.004325887,
0.011929162,
-0.00034043283,
0.005486491,
0.016947456,
-0.05009061,
0.015246116,
-0.009350775,
0.031652834,
0.0046786848,
-0.016617738,
-0.01680238,
-0.0038774721,
-0.0040588165,
0.014085512,
0.014032757,
-0.008460538,
0.06684024,
0.011052115,
0.003158689,
0.020693041,
-0.019242285,
0.023014247,
0.00844735,
-0.0007686528,
-0.008559454,
-0.047241855,
0.0124105485,
-0.01649904,
0.021682192,
-0.024174852,
0.0021134862,
0.024768343,
-0.037086572,
-0.012984256,
-0.027933626,
-0.050354384,
0.042335667,
-0.017409058,
0.009542011,
0.027748985,
-0.027432457,
-0.02478153,
0.016037436,
-0.0069372463,
0.004827057,
-0.0005514517,
-0.0010056369,
-0.00074722123,
-0.056711327,
-0.0052622836,
-0.014982342,
0.0064987224,
0.017778343,
0.008631992,
0.003279036,
0.0047907885,
-0.021616248,
0.0035609438,
-0.0155098885,
-0.031441815,
0.008533076,
0.008592426,
0.0022025097,
0.0049820244,
-0.009126567
] |
Studying the metabolism of immune cells in recent years has emphasized the tight link existing between the metabolic state and the phenotype of these cells. Macrophages in particular are a good example of this phenomenon. Whether the macrophage obtains its energy through glycolysis or through oxidative metabolism can give rise to different phenotypes. Classically activated or M1 macrophages are key players of the first line of defense against bacterial infections and are known to obtain energy through glycolysis. Alternatively activated or M2 macrophages on the other hand are involved in tissue repair and wound healing and use oxidative metabolism to fuel their longer-term functions. | [
-0.017460166,
-0.024744958,
-0.011102177,
-0.031731617,
-0.013377054,
0.006390395,
0.007485706,
0.017226845,
-0.02544492,
-0.021219222,
0.029657654,
0.006351508,
0.017330544,
-0.0050682444,
-0.01793977,
-0.00515898,
0.041142218,
0.0046372493,
-0.016915752,
-0.0015157745,
-0.035957314,
0.025807863,
-0.013221507,
-0.026857806,
0.016643545,
0.016371336,
-0.0006995571,
-0.023085788,
-0.007129244,
-0.023604278,
0.015697299,
-0.021284033,
-0.020234091,
0.0037752588,
0.0101948185,
-0.015826922,
0.027817013,
-0.0027528603,
0.014582545,
0.0040831123,
0.0049321405,
0.0036585983,
-0.0021646977,
0.004825202,
0.020843316,
0.004115518,
0.0037493343,
-0.015826922,
-0.0062607722,
0.013227988,
0.012754865,
-0.0060209706,
-0.0057746875,
0.011017922,
-0.026196731,
0.0066496404,
-0.02750592,
0.003238945,
-0.02539307,
-0.029268786,
-0.017836072,
-0.0036423956,
-0.015956543,
0.0033896314,
0.0110373655,
0.005324249,
0.00004911482,
0.022061769,
0.0042419,
-0.00084173685,
0.028413277,
0.015269544,
0.002848457,
0.017265733,
0.01272246,
-0.028491052,
-0.024887543,
0.013882582,
0.0061084656,
0.00014329376,
0.014634393,
-0.020998864,
-0.0063774325,
0.038601615,
0.0022538132,
-0.0123335915,
-0.005314527,
0.004847886,
0.018445298,
-0.017499054,
0.017758299,
0.004099315,
0.04733818,
0.031394597,
-0.0074727437,
0.024032032,
-0.012845601,
0.018030506,
0.000323854,
0.002310523,
-0.029268786,
0.0099226115,
-0.027765164,
-0.027091127,
-0.04264584,
0.020558147,
0.0017142592,
0.007634772,
0.023604278,
0.009274499,
-0.0025859713,
0.0271689,
-0.0018941105,
-0.04637897,
0.005376098,
0.021698825,
0.025198637,
-0.0006594551,
-0.0042256974,
0.00037408277,
0.009203206,
0.027479995,
0.007589404,
-0.012417846,
0.019508203,
-0.0029764592,
-0.019819299,
-0.00533073,
-0.03274267,
-0.0031271456,
0.019456355,
0.00013428093,
0.020376675,
0.0098578,
-0.020337788,
0.013001149,
-0.026300428,
0.0017693487,
-0.007044989,
-0.017719412,
0.009086546,
0.028231805,
0.004144683,
0.016371336,
-0.0057358006,
0.015347318,
0.039405275,
0.0110373655,
-0.023319108,
-0.002143634,
0.009099508,
-0.011393828,
0.030979805,
-0.0037201692,
0.033157464,
0.004504386,
0.000119192046,
0.022152506,
-0.045367915,
-0.005888107,
0.0056547867,
-0.026507825,
0.0066496404,
0.0025535654,
-0.012968742,
0.018173091,
0.002091785,
0.018432336,
0.016423186,
-0.020195203,
0.0081403,
0.029372485,
-0.007971791,
0.036994293,
0.0072005363,
0.037460934,
-0.0033118578,
0.014077016,
-0.01524362,
-0.023254298,
0.01129013,
0.023967221,
0.018082354,
-0.015178808,
-0.0064292816,
0.02068777,
0.02929471,
0.000045874254,
0.0011090835,
-0.027842937,
-0.004682617,
0.024719033,
-0.0010296897,
-0.0019783652,
-0.6491501,
-0.016034318,
0.0065783476,
-0.019093411,
-0.011601225,
0.031550143,
0.010551281,
-0.03432407,
-0.0060728197,
0.019054525,
-0.009676328,
0.0004832493,
-0.009313385,
-0.026494863,
-0.006999621,
-0.044719804,
-0.014712167,
-0.017447203,
-0.010966074,
-0.019274883,
-0.022489524,
-0.018523071,
-0.0042775464,
0.0143881105,
-0.015152884,
0.01799162,
0.022645071,
0.0033604663,
0.0032535277,
0.060818933,
-0.024485713,
0.010907743,
-0.0015319773,
-0.021296997,
0.050604668,
0.0035905465,
-0.009760583,
0.022956165,
0.008866187,
0.007122763,
-0.01403813,
-0.006458447,
-0.0044849426,
0.0137399975,
-0.01777126,
0.030020598,
0.0058945883,
0.027479995,
0.0060663386,
0.009384678,
-0.01209379,
0.021141449,
-0.014932525,
0.0005525164,
0.03072056,
0.013675186,
0.025017165,
-0.011238281,
0.0048932536,
0.021634014,
0.016228752,
0.01978041,
0.017849034,
-0.02316356,
-0.033157464,
0.030590937,
-0.017032411,
-0.000086988926,
-0.011912318,
0.005188145,
0.013999242,
0.0353092,
-0.02539307,
0.012255819,
0.0026264782,
0.014323299,
0.004692339,
0.018082354,
-0.009378197,
0.032379728,
0.0012646307,
-0.0054247063,
-0.019171186,
-0.007569961,
0.026222656,
-0.011102177,
0.00057884597,
0.007239423,
-0.0035808247,
-0.006921848,
0.02631339,
-0.008231036,
-0.011653073,
-0.057811685,
-0.014569582,
0.02750592,
-0.029476183,
-0.005392301,
0.0059820837,
-0.025794901,
-0.026274504,
0.00020942155,
0.012715979,
0.018548997,
0.033857428,
0.0033507447,
-0.029890975,
-0.013856658,
0.041634783,
-0.029968748,
0.015334356,
0.003972933,
0.005680711,
0.006208923,
-0.0098253945,
-0.018510109,
0.03748686,
0.0033637069,
-0.0072264606,
-0.02830958,
0.025717126,
-0.0031951976,
0.014712167,
0.0014517733,
0.0123335915,
0.014284412,
0.0027269358,
-0.029087314,
-0.0058265366,
-0.016371336,
0.012016016,
-0.00045854002,
0.014595507,
-0.0040020985,
0.01869158,
0.014193676,
0.0063255834,
-0.0037234097,
0.014647355,
-0.031264976,
-0.01071979,
-0.022891354,
-0.006921848,
-0.030565012,
-0.017978657,
0.023928335,
-0.009592074,
-0.007641253,
0.016319487,
0.009656885,
0.007090357,
0.01994892,
-0.012787271,
0.0048219613,
0.030020598,
-0.0058427393,
-0.030020598,
0.0055284044,
0.0029197494,
0.0183416,
-0.016889827,
0.011082734,
0.0056029377,
0.013493714,
-0.024369052,
-0.0049094567,
-0.0038141455,
0.0027010113,
-0.030227995,
-0.0326649,
-0.00842547,
-0.0143881105,
-0.016539846,
0.013046516,
0.0040733907,
0.012281743,
-0.012566913,
-0.00014693939,
-0.004941862,
-0.0066172346,
0.017965695,
-0.014971412,
0.00055494683,
0.013325205,
0.0341426,
0.014478846,
0.020247053,
-0.0140122045,
0.008418989,
0.052523084,
-0.0009640682,
0.034168523,
-0.0044330936,
0.008088451,
-0.0018114761,
-0.029839126,
-0.009987422,
0.0033799098,
-0.0012127816,
0.026961504,
0.0011188053,
-0.03924973,
-0.002069101,
-0.020195203,
0.014219601,
-0.0237339,
0.009093027,
-0.00601773,
0.015217695,
0.0066755647,
-0.0049321405,
0.006895923,
0.013390016,
-0.013597412,
0.026624486,
0.012320629,
0.009468932,
0.0066561215,
-0.0046307677,
-0.027842937,
0.018937863,
0.013999242,
0.026235618,
-0.008606941,
-0.01295578,
0.012696535,
-0.0030331693,
0.027194824,
-0.035231426,
-0.017512016,
0.003862754,
-0.009125432,
0.015412129,
0.0034025938,
0.036527652,
0.023020977,
0.00094786537,
-0.013519639,
0.020389637,
0.011478082,
0.0050228764,
0.008224555,
0.014932525,
-0.0020966458,
0.00089196564,
0.005706636,
0.03484256,
-0.009553187,
-0.010253149,
0.0036326738,
-0.022658033,
0.010330923,
-0.005175183,
-0.0017239808,
-0.0027933675,
-0.0012054903,
0.0052918433,
0.0026426811,
0.021478467,
0.01552879,
-0.017602751,
-0.015723223,
-0.016254677,
-0.012683573,
-0.001770969,
0.021958072,
0.019365618,
-0.012288224,
-0.00035038614,
0.0071098004,
-0.046560444,
0.02499124,
-0.0018730467,
-0.023707977,
0.015425092,
0.01381777,
0.008192149,
-0.016708355,
0.03450554,
0.028646598,
-0.0038757161,
-0.010817007,
0.0055802534,
0.017291658,
0.0040960745,
-0.028413277,
-0.03712392,
-0.0047312253,
-0.009650404,
0.0046340087,
0.011471601,
0.012858563,
-0.021724751,
0.0050747255,
-0.024213504,
-0.011186432,
0.026326353,
-0.027920712,
0.037175767,
0.005233513,
0.009488376,
0.017732374,
-0.01524362,
0.004802518,
0.024330165,
0.013234469,
-0.0005026927,
-0.008691196,
-0.0066561215,
-0.037046142,
-0.009624479,
-0.00641956,
0.0034998106,
-0.005508961,
0.0040539475,
0.0034868484,
-0.033779655,
0.017797185,
0.039483048,
-0.011698441,
0.011925281,
-0.022308052,
0.005495999,
-0.017732374,
0.032172333,
0.0054603526,
0.0025535654,
0.011192913,
-0.0032178815,
0.021659939,
0.010829969,
-0.014647355,
0.023357995,
-0.008639348,
-0.0016332449,
-0.0053177676,
0.018782318,
0.0002543844,
0.018211978,
0.013519639,
0.0030364098,
-0.0050974092,
-0.01736943,
-0.0024595892,
0.0022343697,
-0.025237523,
0.030357616,
0.022022882,
0.02522456,
0.006980178,
0.0022943204,
0.014828827,
-0.018276788,
-0.020597033,
-0.011166988,
0.0152306575,
0.0008113566,
0.0062251263,
-0.015982468,
-0.016708355,
-0.0014542037,
-0.0048802914,
0.011141064,
0.0061019845,
0.014426997,
0.008017159,
0.0061408714,
0.012009535,
0.01495845,
0.01048647,
0.012067866,
0.016436148,
0.014452921,
-0.012443772,
0.039327502,
-0.020363713,
-0.01604728,
-0.023941297,
-0.015010299,
0.006332065,
-0.0024514878,
-0.008127338,
-0.0060436544,
0.010447583,
-0.0039016407,
-0.026235618,
0.024615334,
-0.007816244,
-0.0078680925,
0.008807857,
0.004228938,
-0.036372107,
-0.030876108,
-0.003088259,
0.021621052,
-0.029994674,
-0.0067598196,
0.008457876,
0.011653073,
0.037175767,
-0.0009033076,
-0.010966074,
0.008302328,
0.019560052,
-0.026352277,
0.010862376,
-0.0142973745,
-0.046923388,
0.00240774,
-0.008263442,
0.004488183,
-0.02132292,
-0.010518875,
-0.006406598,
0.007744951,
-0.012476177,
-0.008477319,
0.012975224,
-0.031601995,
0.009598555,
0.0037363719,
0.006383914,
-0.023461694,
-0.011951205,
-0.00693481,
-0.014828827,
-0.0074208947,
-0.007044989,
-0.02241175,
-0.027920712,
0.0058524613,
0.0054992395,
-0.01312429,
0.0008052805,
0.024304241,
-0.017019449,
0.013143733,
0.0043650414,
0.016241714,
0.024511637,
0.0030056245,
0.016786128,
0.012203969,
-0.016358374,
-0.007492187,
-0.0098578,
0.021335883,
0.017162034,
-0.025263447,
0.0103827715,
-0.012800233,
-0.0053339708,
-0.0046793763,
-0.0140122045,
-0.015723223,
0.0008490281,
0.0009932333,
-0.028361429,
-0.023539467,
-0.0020075303,
-0.00768014,
0.0005760105,
0.0055640507,
0.0038076644,
-0.011458639,
-0.0021971033,
0.001002955,
-0.00945597,
0.04023486,
-0.036372107,
-0.026857806,
0.018989714,
-0.008328253,
0.008846744,
-0.02929471,
-0.013610375,
-0.020882204,
-0.0050974092,
-0.004423372,
-0.01828975,
-0.006053376,
-0.003541938,
0.044382785,
0.022554334,
0.02035075,
0.0031255253,
0.03924973,
0.025885636,
-0.0018568439,
-0.014660317,
-0.0088273,
0.009164319,
-0.028179957,
0.0063871546,
0.010467026,
-0.0088013755,
0.00412524,
0.017330544,
0.009054139,
0.025133826,
-0.012975224,
-0.012677092,
-0.006986659,
-0.031550143,
-0.036086936,
0.042853236,
-0.024706071,
0.0010045753,
-0.03720169,
-0.03432407,
0.016617619,
0.011186432,
0.0100068655,
0.011614187,
0.0143881105,
-0.018147167,
0.037979428,
-0.015891733,
0.008185668,
-0.0123400735,
-0.0006468979,
0.0031125632,
-0.0018195774,
0.0063709514,
0.010616092,
0.0003072461,
-0.007926423,
-0.007952347,
0.02745407,
-0.008555093,
-0.016604656,
-0.025418995,
-0.014906601,
-0.026961504,
-0.01427145,
-0.0010329302,
-0.008120857,
-0.018756393,
-0.009313385,
0.003370188,
-0.024615334,
-0.0040020985,
-0.023176523,
-0.012139158,
0.048297387,
0.009352271,
0.019274883,
-0.04168663,
0.025743052,
-0.0029845608,
0.0032227424,
-0.021102563,
-0.0039178436,
0.0044460557,
-0.01730462,
0.025004202,
-0.017460166,
-0.016125053,
-0.01943043,
0.018108279,
-0.0033604663,
0.007083876,
-0.012631724,
0.017473128,
0.008775451,
-0.0044330936,
-0.03214641,
-0.007044989,
-0.039120104,
0.0030688155,
-0.0043650414,
0.012703016,
0.0031303861,
-0.0019816058,
-0.01793977,
0.041194066,
0.012683573,
-0.0014169372,
0.008788413,
-0.015282506,
0.016993525,
-0.039820068,
-0.010966074,
0.017732374,
-0.0010693866,
0.018030506,
-0.010564243,
0.012411365,
0.019300807,
0.0031206645,
0.0013683287,
0.0061538336,
0.0008433571,
0.03616471,
-0.008794894,
0.0052983244,
0.012424327,
0.01736943,
0.024498675,
-0.0029910419,
-0.00016030672,
-0.013791846,
-0.0010394114,
0.007667178,
0.011076253,
0.0022278887,
-0.017434241,
-0.012223412,
-0.015956543,
-0.009980941,
-0.023915373,
-0.022048807,
-0.0039340463,
-0.0033961125,
0.009993903,
-0.0033248202,
0.011186432,
0.00056831416,
-0.0046793763,
0.0057876497,
-0.025418995,
0.024459787,
-0.010609611,
0.04254214,
0.0022214076,
-0.0031546904,
0.0055510886,
0.0088921115,
-0.019585976,
-0.024641259,
0.014414035,
-0.0024952353,
-0.04189403,
-0.021115525,
-0.0009097887,
0.009592074,
0.01071979,
-0.001042652,
0.005204348,
0.012009535,
0.030279843,
-0.006001527,
0.00015706616,
0.021102563,
-0.027246675,
-0.012145639,
0.022217317,
-0.011192913,
-0.016578732,
0.004115518,
-0.026455976,
-0.0074144136,
-0.011931762,
-0.039534897,
-0.047441877,
0.016591694,
-0.019573014,
0.023137636,
0.014025167,
-0.011970649,
-0.0042710654,
0.013040035,
0.0119188,
0.0034771266,
-0.015775071,
-0.0091708,
0.005181664,
0.0057973713,
-0.014932525,
0.007187574,
-0.0036845228,
-0.0073107155,
-0.008743046,
-0.002882483,
-0.037564635,
0.034972183,
-0.0052724,
-0.00968929,
-0.02963173,
0.0140122045,
-0.03852384,
-0.012936337,
0.0059918053,
0.0058265366,
0.001650258,
0.005531645,
-0.00040932393,
-0.002258674,
0.007122763,
-0.0068699988,
-0.04342358,
-0.014141828,
-0.005687192,
-0.012281743,
0.007479225,
-0.0040831123,
-0.0016470173,
-0.0067014894,
0.0105707245,
-0.015788035,
0.013338167,
0.0051038903,
-0.009443007,
0.026274504,
-0.007861611,
0.0091772815,
0.00974114,
0.014064054,
0.048789952,
-0.018004581,
0.0019573015,
0.028853994,
-0.006798706,
-0.015425092,
-0.016462073,
0.0016672709,
-0.0052659186,
0.024550524,
-0.0013723795,
-0.025756015,
0.009715215,
-0.015386204,
0.017926808,
0.028387353,
-0.027298523,
0.00032993007,
-0.003862754,
-0.04469388,
-0.01720092,
-0.0041479236,
-0.019650789,
0.008697677,
0.0003805639,
0.005249716,
-0.008341216,
-0.0033377823,
0.029890975,
-0.021128487,
-0.010933667,
-0.009883724,
0.011050328,
-0.0110373655,
-0.005978843,
-0.00051727524,
-0.025717126,
-0.015697299,
0.007790319,
-0.0064811306,
-0.0035549002,
0.01869158,
-0.0016948157,
0.019495241,
-0.003078537,
-0.0013748099,
0.0014866093,
-0.010518875,
-0.0072005363,
-0.014634393,
-0.01415479,
0.021154411,
0.1907008,
-0.027687391,
-0.013571488,
0.044460557,
-0.000647708,
-0.012852082,
0.0013294419,
-0.01679909,
0.0044039283,
0.004993711,
0.027065203,
0.0026864286,
-0.00045610958,
-0.001638916,
0.010285554,
-0.002997523,
-0.01954709,
-0.010460545,
-0.009255054,
-0.030642787,
-0.016915752,
-0.015917657,
0.019819299,
-0.007719027,
0.035335124,
-0.0010629054,
-0.016539846,
0.012696535,
0.009676328,
-0.008451395,
-0.00046623635,
0.02063592,
0.00056952937,
0.017187959,
-0.003055853,
0.026261542,
-0.017550902,
-0.013098366,
0.028102184,
-0.004368282,
0.013020592,
0.007829206,
-0.0052011074,
0.005262678,
0.009462451,
0.01656577,
-0.022204354,
0.004672895,
-0.0076088477,
-0.015399166,
-0.03691652,
-0.019806337,
0.0041673672,
-0.00659131,
0.030072447,
-0.00865231,
0.014064054,
0.024485713,
0.008094932,
0.0045270696,
-0.022956165,
-0.0006157074,
-0.025756015,
0.025859712,
0.0025470844,
0.016682431,
-0.010473507,
-0.0103827715,
-0.0069607343,
-0.013001149,
-0.003490089,
0.0048414045,
0.0011042226,
-0.019391544,
-0.0004962116,
0.006889442,
0.016150977,
0.009507819,
-0.0016065103,
0.01283912,
0.00029084075,
-0.007582923,
-0.03300192,
-0.0020658604,
0.008120857,
-0.02665041,
0.014401073,
0.0024725513,
-0.040934823,
0.013189102,
-0.0015838264,
-0.003869235,
-0.01249562,
0.0026151363,
-0.0024498675,
-0.0140122045,
0.015425092,
0.004601603,
0.003616471,
-0.021815486,
-0.030072447,
0.06626308,
0.0065329797,
0.005875145,
-0.012767828,
0.017524978,
-0.013325205,
0.019093411,
0.0034317588,
-0.0060047675,
0.021867335,
-0.03162792,
-0.008496762,
-0.015684336,
0.0041122776,
0.030979805,
-0.008263442,
-0.023915373,
0.018536035,
-0.008153263,
-0.010726271,
-0.014141828,
0.016915752,
-0.00028901792,
-0.009384678,
0.0036002682,
-0.027817013,
0.025030127,
0.0003153475,
-0.025665278,
-0.009553187,
-0.01845826,
-0.0014809384,
0.025043089,
-0.015139922,
0.009838357,
0.0059010694,
-0.014323299,
-0.012028979,
0.016669469,
-0.03318339,
-0.013195583,
0.02063592,
0.019573014,
0.018898977,
-0.01117347,
0.009760583,
0.010447583,
-0.011769733,
-0.0066626025,
-0.0022554335,
-0.00624781,
-0.016954638,
0.0045303106,
0.016669469,
-0.014919563,
-0.0053825793,
-0.008030121,
-0.004692339,
-0.0031838554,
-0.014893639,
0.011400309,
0.0019232755,
-0.014932525,
-0.0004974268,
-0.010713309,
-0.16135423,
0.008503243,
0.016293563,
-0.007647734,
0.0210896,
0.014738091,
0.0057973713,
-0.00043990675,
-0.009890205,
0.006046895,
0.025833787,
-0.017615713,
-0.051149085,
-0.010551281,
0.010642016,
0.00047271748,
0.009890205,
0.033572257,
-0.007699583,
0.0073366403,
0.026455976,
-0.03691652,
-0.005243235,
-0.006503815,
0.010343885,
0.013545563,
0.014128865,
0.031990863,
-0.013163176,
-0.024783844,
-0.010804045,
-0.0010507533,
0.0016705114,
0.0106679415,
0.020298902,
0.0030137259,
0.009935574,
0.004361801,
0.002986181,
0.009417083,
0.048064064,
-0.0056159,
-0.005346933,
0.0013164796,
-0.019508203,
-0.0016210928,
0.013273356,
0.011860469,
0.025263447,
-0.00020466196,
0.012826158,
0.00252278,
-0.0019816058,
0.016436148,
0.025302334,
0.017019449,
0.01593062,
0.020104468,
-0.0011560717,
-0.0169676,
-0.0067014894,
-0.026494863,
0.02005262,
0.008762489,
-0.00047879355,
-0.0004378814,
0.0020447967,
0.0062121637,
-0.0102013,
0.0002503337,
-0.024667183,
-0.008930998,
0.0063255834,
-0.009520781,
0.026805958,
0.019987807,
-0.009553187,
-0.0038076644,
0.0028354947,
0.013727035,
-0.0028581787,
-0.0021193298,
-0.034946255,
-0.013843696,
-0.016682431,
0.0217766,
0.027868863,
0.014025167,
-0.0077514322,
-0.009293942,
0.0054992395,
-0.035672143,
0.000032000582,
-0.027117051,
0.04005339,
0.019093411,
0.0036456361,
-0.0033248202,
-0.008237517,
0.00093895383,
0.010130008,
-0.011212356,
-0.027091127,
0.017589789,
0.016345412,
-0.014128865,
-0.0053274897,
-0.0089893285,
0.049360294,
-0.019456355,
-0.00922913,
-0.0015805857,
0.011218837,
0.034687012,
-0.012489139,
0.035620295,
0.017563865,
-0.018004581,
-0.0005816815,
-0.016487997,
0.041868106,
0.0064163194,
0.005359895,
0.028646598,
-0.001364278,
-0.028335504,
-0.13304466,
-0.021193298,
-0.007673659,
-0.022191392,
-0.00469882,
-0.0063191024,
0.0010410317,
-0.0012921755,
-0.010616092,
0.008593979,
-0.02298209,
0.007129244,
-0.005816815,
-0.006973697,
-0.0005553519,
-0.012443772,
0.0044784616,
0.010590168,
-0.019002676,
0.025341222,
-0.004993711,
-0.0072199795,
-0.02475792,
-0.0036877634,
0.015684336,
0.010901262,
-0.02797256,
0.02820588,
-0.0008603701,
0.011361422,
0.02154328,
0.0085162055,
0.027765164,
-0.003765537,
0.010700347,
0.010246668,
0.015852846,
-0.02132292,
0.018847128,
-0.016125053,
-0.018847128,
0.019080449,
0.022567298,
-0.009605036,
0.008581017,
0.0005193006,
-0.02482273,
-0.0011998194,
0.0062607722,
-0.02447275,
-0.015282506,
0.0008190529,
-0.04658637,
-0.032379728,
0.0074468195,
-0.031368673,
-0.012106752,
0.02350058,
-0.0027528603,
0.007142206,
0.0059626405,
0.0049839895,
-0.0034349994,
0.0052011074,
0.019326732,
-0.043190256,
-0.010752196,
-0.036138784,
0.0067014894,
-0.040545955,
0.02303394,
0.00029873961,
0.0023251057,
-0.0100133475,
-0.018600846,
-0.014893639,
0.020480374,
-0.0065524234,
-0.0018681859,
-0.012385441,
-0.014414035,
-0.0011965787,
0.002683188,
-0.015891733,
0.03398705,
0.022074731,
0.010110564,
-0.009157837,
0.019339694,
-0.01415479,
-0.021050712,
0.049256593,
0.013480752,
-0.03512773,
-0.00796531,
0.01690279,
0.008697677,
0.0142973745,
0.00997446,
0.02556158,
-0.00687648,
-0.02320245,
-0.038005352,
0.022774694,
-0.00974114,
0.010000384,
0.007032027,
-0.0020253535,
-0.00018562363,
-0.023319108,
0.013377054,
0.03123905,
0.0035095324,
0.0021452543,
-0.007589404,
-0.019106373,
-0.038420144,
-0.02750592,
0.0010669562,
0.0036521172,
0.005256197,
0.02475792,
-0.008529169,
0.014426997,
0.005696914,
0.013253912,
-0.01644911,
0.013163176,
-0.026494863,
0.033546332,
-0.011341979,
-0.034998108,
-0.004890013,
-0.031005729,
-0.001037791,
0.019961882,
-0.020778505,
-0.013428903,
0.0024498675,
0.012417846,
0.009812432,
0.039405275,
-0.019754486,
-0.018665656,
-0.008418989,
-0.036890596,
0.0073560835,
-0.003117424,
-0.013415941,
0.011737328,
-0.001610561,
-0.019210072,
0.043942068,
0.013377054,
-0.022100655,
-0.05070837,
0.0018892497,
0.00034714557,
0.007978272,
0.0025211598,
-0.023293184,
-0.028905842,
0.018665656,
0.023293184,
0.012683573,
0.01117347,
-0.0009268017,
-0.020532222,
-0.013558526,
0.0104799885,
0.0013650882,
-0.0380572,
-0.008866187,
0.012767828,
0.014478846,
0.00046097042,
0.020532222,
0.0005658837,
0.0010151071,
0.006293178,
0.01077164,
0.028024409,
0.008004197,
-0.016034318,
-0.016228752,
0.01793977,
0.045782708,
0.0036261927,
-0.02045445,
0.02750592,
-0.01083645,
-0.0025114382,
0.0123400735,
0.024006108,
0.0074533005,
-0.0107586775,
0.020571109,
0.010473507,
0.012022498,
0.008360659,
-0.009436526,
0.031964935,
-0.000088254776,
0.010130008,
0.014686243,
-0.039457124,
0.0022327495,
0.024148693,
-0.040831123,
-0.027583692,
-0.029553957,
0.016747242,
0.007822725,
0.024667183,
-0.0029926621,
-0.0070579513,
-0.023811674,
0.005583494,
-0.019663751,
-0.013856658,
-0.01318262,
0.012100271,
0.020376675,
0.014815865,
-0.00997446,
-0.014310337,
0.009980941,
0.011575299,
0.027920712,
-0.0107586775,
0.0217766,
0.010447583,
0.018186053,
-0.004475221,
-0.02820588,
-0.023993146,
-0.015399166,
-0.040079314,
0.012566913,
0.03072056,
-0.00435532,
0.048867725,
-0.0006882151,
-0.013947394,
-0.014219601,
-0.008062527,
0.03243158,
0.014776979,
0.029450258,
-0.012100271,
-0.00447198,
0.013623337,
-0.024563486,
0.010551281,
-0.0339352,
-0.026209693,
0.022709882,
-0.020000769,
-0.00028476468,
0.008444914,
-0.008548612,
0.017395355,
-0.00894396,
0.023928335,
0.008853225,
-0.014880677,
-0.021063674,
0.04269769,
-0.01713611,
0.014245526,
-0.029994674,
0.024032032,
-0.0025778697,
-0.057915386,
-0.01031796,
0.014712167,
-0.008555093,
-0.011147545,
-0.029424334,
0.015839884,
0.016928714,
-0.0072459043,
-0.0124308085,
-0.023008015,
-0.019300807,
-0.012865044,
-0.008976366,
-0.01713611,
-0.009015253,
-0.019274883
] |
BACKGROUND Recent studies suggested that human/mammalian genomes are divided into large, discrete domains that are units of chromosome organization. CTCF, a CCCTC binding factor, has a diverse role in genome regulation including transcriptional regulation, chromosome-boundary insulation, DNA replication, and chromatin packaging. It remains unclear whether a subset of CTCF binding sites plays a functional role in establishing/maintaining chromatin topological domains. RESULTS We systematically analysed the genomic, transcriptomic and epigenetic profiles of the CTCF binding sites in 56 human cell lines from ENCODE. We identified ~24,000 CTCF sites | [
-0.028664185,
-0.013922227,
0.0047894837,
-0.019871896,
-0.0073709795,
0.016130215,
-0.03527493,
0.031361368,
-0.01865552,
0.0032458752,
-0.003062427,
0.003583023,
0.000042324256,
0.0069809454,
-0.0022707905,
-0.000611907,
0.025570357,
-0.025543915,
-0.021088272,
-0.00011207277,
-0.030039221,
0.015059275,
-0.027394922,
-0.031943116,
-0.011132493,
0.012474474,
0.0013874299,
-0.049104605,
-0.015508805,
-0.028637743,
0.0071792677,
0.010405311,
-0.018470418,
-0.009816955,
-0.014173435,
-0.00470685,
0.008785679,
-0.009783901,
0.0155881345,
-0.018615855,
0.043868896,
0.029483918,
-0.014728737,
-0.005774485,
0.012143937,
-0.010279707,
0.024631632,
-0.008957558,
-0.025596801,
0.013406589,
0.0038871174,
0.034005668,
0.001146964,
-0.005936448,
-0.004630826,
-0.011119272,
-0.0004073871,
0.008990612,
-0.0025600106,
-0.022066664,
-0.00065281097,
-0.0016245904,
-0.0022030305,
0.0013494181,
0.0038441475,
-0.0085080275,
0.008501417,
0.021299817,
-0.009850008,
0.021207266,
0.01643431,
0.021286596,
-0.0020162768,
-0.001852661,
0.02531915,
-0.015455919,
-0.028188212,
0.009770679,
-0.01964713,
0.018510083,
0.0044027553,
-0.00217824,
0.015059275,
0.016143437,
0.009195545,
0.0060653575,
0.0022013776,
-0.02168324,
-0.0021584078,
0.0047960947,
0.0238119,
0.025702571,
0.038262986,
0.008937726,
-0.0081973225,
-0.0060289986,
-0.0038044832,
0.031334925,
0.0016683865,
-0.022608744,
-0.012295984,
0.018364647,
-0.00045448865,
-0.012500917,
-0.023203712,
-0.0064653074,
0.026152102,
-0.004363091,
0.008587357,
-0.03278929,
-0.018814176,
0.022701295,
-0.03990245,
-0.018642297,
0.04653964,
-0.007999,
0.00078172045,
-0.0113109825,
-0.013935449,
-0.008012221,
0.031229155,
0.028452642,
-0.0042176545,
-0.019224044,
0.023997,
0.0035036942,
-0.013975113,
-0.0064454754,
0.0093211485,
-0.0020625521,
0.0035400533,
-0.006346314,
0.0040358594,
0.023798678,
-0.020109883,
-0.017386256,
-0.005278679,
0.0024591968,
0.002746764,
-0.025927337,
0.0175978,
0.03797211,
-0.02186834,
-0.018933171,
0.024314316,
0.019329816,
0.0040061106,
-0.0034904727,
0.02648264,
0.0068288986,
0.004915088,
-0.008283262,
0.025358813,
0.034613855,
0.012203434,
0.018377868,
0.003204558,
0.023785457,
0.012467863,
-0.032974392,
-0.00702061,
0.022595523,
0.030700294,
0.010392089,
0.021392368,
0.024274651,
0.012467863,
-0.032101773,
0.013565247,
-0.0067594857,
0.017624244,
0.015323704,
-0.035222042,
0.014279207,
-0.028452642,
-0.006666935,
-0.007985779,
0.027011499,
-0.020321427,
-0.010226821,
-0.012401756,
0.0222121,
0.019144714,
-0.006809066,
-0.02382512,
-0.03643842,
0.012930615,
-0.0031186184,
-0.010504472,
-0.016897062,
-0.0018807567,
-0.001763416,
0.014094106,
-0.0027930392,
-0.6287082,
0.009017055,
0.007813899,
-0.038950503,
-0.005490223,
0.005672018,
-0.005417505,
0.0018394395,
-0.026628077,
0.015614578,
-0.010669741,
0.015945114,
0.0118927285,
-0.02444653,
-0.050796956,
-0.050373867,
-0.023375591,
-0.007569302,
0.019290151,
0.015826121,
-0.004211044,
0.0019914866,
-0.020850286,
0.02710405,
0.004614299,
0.0037747347,
0.039770234,
0.010682962,
-0.0045812456,
0.019964447,
-0.014808066,
0.0051233266,
-0.010940781,
0.005205961,
0.042943392,
0.0011097786,
0.0009841745,
0.020017333,
0.008455141,
0.033820566,
-0.004994417,
-0.009175712,
0.029933449,
0.021617133,
-0.028135326,
0.021934448,
-0.012024943,
0.014503972,
0.0054439474,
-0.0026542137,
-0.005384451,
-0.00032557914,
-0.022450086,
0.0069809454,
0.005695156,
0.0032144743,
0.01742592,
-0.033926338,
0.016778069,
-0.0076750736,
-0.015363369,
0.006382673,
-0.005153075,
-0.031387813,
-0.011925782,
0.013975113,
-0.0067297374,
-0.0035797178,
0.018007666,
0.0065115825,
0.00027042074,
0.0049811956,
-0.0019452114,
-0.017981224,
0.015773235,
0.018073773,
0.021458475,
-0.006673546,
-0.0008618757,
0.012514139,
-0.004303594,
0.012467863,
0.0073974226,
0.0016667338,
0.014490751,
0.015165047,
-0.0018344815,
0.028928615,
-0.012381923,
-0.0127190715,
-0.0077015166,
-0.0002565795,
0.0019435587,
-0.023507806,
-0.023613578,
0.021075051,
0.011330815,
-0.007523027,
-0.013439642,
-0.017716793,
0.007846953,
-0.02853197,
0.006690073,
0.007589134,
0.011152325,
-0.0003187618,
-0.004594467,
0.011502694,
0.047200713,
-0.0074965837,
-0.00889145,
0.004072218,
-0.018179545,
0.0010395395,
0.00977729,
-0.017095383,
-0.0014287471,
0.027447809,
-0.014371757,
0.0016427699,
0.013975113,
0.010464808,
-0.0043862285,
-0.011628298,
0.012229877,
0.019805789,
0.024367202,
-0.018853841,
0.0062339315,
-0.019792568,
-0.0013320649,
0.006005861,
0.026284318,
-0.03511627,
0.041065942,
0.029007943,
0.019911561,
0.009850008,
0.004068913,
-0.021313038,
-0.016592966,
0.00032805817,
0.01324132,
0.003404533,
-0.004072218,
-0.008679907,
-0.023124382,
-0.0004958058,
-0.00817749,
-0.013439642,
0.0069280597,
0.012322427,
-0.017346593,
0.01252736,
-0.0032376118,
-0.013988334,
-0.007073496,
-0.04061641,
-0.0036656575,
-0.044133328,
0.00019945853,
-0.0048655076,
-0.011086217,
-0.0031979473,
0.021484917,
-0.014794845,
0.002710405,
0.010530915,
-0.008012221,
-0.039770234,
0.014517194,
-0.020162769,
-0.031387813,
0.017901894,
-0.008296483,
0.016989611,
-0.0062603746,
0.0010139229,
-0.027685795,
-0.027024722,
-0.023150826,
-0.0061810454,
-0.013604911,
-0.026085995,
0.032630634,
0.017558135,
0.01857619,
0.011231654,
-0.0005842245,
0.026204988,
-0.0055133603,
-0.0032508334,
-0.03387345,
0.025173713,
0.019726459,
-0.016447531,
0.013644575,
0.0005507576,
-0.0043135104,
0.010967224,
-0.000768499,
0.0066603245,
-0.003204558,
-0.0344552,
0.016090551,
-0.022251764,
-0.019792568,
-0.013512361,
-0.009003833,
-0.014027999,
0.007152825,
-0.0004117254,
0.010325982,
0.0071329926,
-0.0061182436,
0.02595378,
-0.013671018,
-0.0069677243,
-0.002541831,
-0.01226293,
0.0000030213166,
0.01546914,
0.032895062,
0.014437865,
-0.0005759611,
0.013657797,
-0.008236987,
-0.0025021667,
0.009916116,
-0.0004974585,
-0.014279207,
0.022793844,
-0.002416227,
-0.0020542888,
-0.0017518471,
-0.008131215,
0.035036944,
-0.024155658,
0.026680963,
0.021101495,
0.009664908,
0.0073974226,
0.011972058,
-0.024658075,
-0.0023583828,
-0.0070338314,
0.024552302,
0.017941559,
0.006742959,
0.0033979223,
-0.010240043,
0.0070073884,
-0.020413978,
-0.0005519971,
0.0054274206,
-0.0030806067,
-0.0084683625,
0.00045572815,
0.038580302,
0.008303095,
0.01590545,
-0.012236487,
0.008256819,
-0.026376868,
0.0008618757,
-0.005172907,
0.009288095,
-0.013697461,
-0.010273096,
0.00897739,
-0.006574385,
0.020810623,
0.0054042833,
-0.017386256,
0.005989334,
0.011337426,
0.0064553916,
0.021722905,
0.0065115825,
0.0070139994,
-0.012712461,
-0.031758014,
0.031123383,
0.023970557,
-0.010597022,
0.0030921753,
-0.018470418,
0.007251986,
-0.015799679,
-0.0059728073,
0.0077874563,
0.006835509,
-0.006078579,
0.0016882187,
0.00043135104,
-0.00060364354,
0.021802234,
-0.021564247,
-0.011211822,
-0.0066801566,
0.0031516722,
-0.006742959,
0.00035264186,
0.0064190323,
0.038500972,
0.01324793,
-0.0072453753,
0.009969002,
-0.01528404,
-0.017901894,
0.0026707405,
-0.004852286,
0.008898062,
-0.0132743735,
-0.015178268,
0.017544914,
0.00059372745,
0.018073773,
0.016050886,
0.0002592651,
-0.016407866,
-0.00626368,
-0.009612022,
-0.0017452363,
0.034587413,
0.023441698,
-0.01803411,
-0.00068173296,
-0.022912838,
-0.00020503635,
-0.023216933,
-0.02452586,
0.012216655,
-0.024539081,
0.0014948545,
-0.0040127216,
0.0035929393,
0.002115438,
-0.0025616633,
0.013657797,
-0.008117993,
-0.024591967,
-0.02266163,
0.018721627,
-0.0016031055,
0.006766096,
0.03207533,
0.055741794,
0.02710405,
-0.006005861,
0.011747292,
0.059919782,
-0.007833731,
-0.010775513,
0.0028938532,
0.011244875,
0.012229877,
0.021802234,
-0.00586373,
-0.02211955,
-0.0027120577,
0.012666185,
0.003394617,
0.00595628,
0.009856619,
-0.005675324,
0.0019584328,
0.006709905,
0.013803233,
0.0035069997,
0.027421366,
0.014146992,
-0.0038408423,
-0.02141881,
0.02382512,
-0.027844453,
-0.012223265,
-0.004425893,
0.009195545,
-0.028902173,
0.0012353827,
-0.010517693,
-0.011337426,
-0.037125938,
-0.015323704,
-0.021564247,
0.0038507583,
-0.005483612,
0.011476251,
-0.0110002775,
-0.0061876564,
-0.02248975,
-0.017042497,
-0.0011312636,
0.018615855,
-0.050849844,
-0.046275206,
0.010385479,
0.023851564,
0.029378146,
0.011119272,
-0.02106183,
0.0010775513,
0.010511083,
-0.0058273706,
-0.015693907,
-0.0021848509,
-0.021722905,
-0.008944336,
0.0022493056,
0.0059463643,
-0.010451586,
-0.005629048,
0.01616988,
-0.0041746846,
-0.0138693405,
0.033000834,
-0.007536248,
-0.007562691,
0.0417799,
0.009883062,
0.020466862,
0.011476251,
-0.014821288,
0.008461752,
-0.0070139994,
0.0045184433,
-0.020242099,
0.0028079136,
0.00062264944,
-0.009473196,
0.0018427449,
-0.018800955,
0.0022988862,
0.019660352,
-0.023243375,
-0.0004883687,
0.0015122077,
0.024724182,
0.006868563,
0.0086138,
0.03038298,
-0.00324257,
-0.028055998,
-0.011767124,
-0.017201155,
0.018496862,
0.002052636,
-0.025795123,
0.017452365,
-0.01030615,
-0.019938003,
-0.021299817,
-0.004587856,
-0.036200434,
0.030673852,
0.0019650436,
-0.008408866,
-0.015879007,
-0.013095884,
-0.014014777,
0.0045514973,
-0.0008874924,
-0.0023716043,
-0.033476807,
-0.010960613,
0.021656796,
-0.025900895,
-0.0037317649,
-0.04016688,
0.005295206,
0.018443976,
0.021630354,
0.02816177,
0.014953502,
0.0045812456,
-0.013710683,
-0.023190489,
-0.009023665,
-0.051405143,
-0.0012196823,
-0.02266163,
0.056905285,
-0.0013461127,
0.045111716,
0.00591331,
-0.0045349705,
0.021286596,
0.03561869,
-0.024486195,
-0.00666363,
0.014292428,
-0.015654242,
-0.012077829,
-0.009089773,
0.004273846,
0.019329816,
-0.021828676,
0.0042606243,
0.028426198,
-0.012289373,
-0.0193827,
0.007800678,
-0.01936948,
-0.02531915,
-0.012507527,
0.004115188,
-0.0027963447,
-0.035671573,
-0.0007292477,
0.03910916,
0.010801955,
0.013961891,
-0.0002507951,
0.022463309,
0.0036028554,
0.021141158,
-0.026337205,
0.003136798,
-0.029219488,
-0.012454641,
-0.0057810955,
0.007516416,
0.046169434,
-0.0024658074,
0.030224321,
0.014001556,
-0.011694406,
-0.019475251,
0.0052885953,
-0.018681962,
-0.010299539,
0.00076602,
-0.0150196105,
0.009314538,
-0.02576868,
-0.014715516,
-0.026033109,
-0.0018510083,
0.0018939781,
-0.008521249,
0.029298818,
-0.000011594625,
-0.008567524,
0.031308483,
0.017135048,
0.028452642,
-0.00906333,
0.02808244,
0.014067663,
0.0076023554,
-0.029483918,
-0.020242099,
-0.017915117,
0.016116994,
0.05304461,
0.022502972,
0.003725154,
0.0074436977,
0.0069346703,
0.0046176044,
-0.023177268,
-0.025266264,
-0.020123104,
0.00018799304,
0.0014229626,
-0.0012411672,
0.01688384,
0.00005174973,
-0.00404247,
-0.005847203,
0.00897739,
-0.0121505475,
-0.016407866,
-0.019250486,
0.011846453,
-0.008124604,
0.009473196,
-0.0007325531,
0.011919172,
0.0020030553,
-0.004875424,
0.008250209,
-0.00083667226,
-0.008904672,
0.036147546,
0.0008098161,
-0.018324982,
0.02408955,
0.018457197,
-0.031255595,
-0.018761292,
-0.017690351,
0.052859508,
0.0063760625,
-0.0025467891,
-0.0077015166,
0.0055067497,
0.0029731821,
0.0064025056,
-0.0057282094,
-0.0038177045,
-0.04175346,
-0.0021815456,
0.017452365,
0.0058075385,
-0.00034995624,
-0.0052290983,
-0.0018658824,
-0.009552525,
-0.047861785,
-0.025702571,
0.025358813,
-0.060131326,
-0.015667463,
0.027950225,
0.024948947,
0.027527137,
0.011522527,
-0.007536248,
-0.01457008,
0.029536804,
-0.036835063,
0.022185657,
0.014067663,
0.00599925,
-0.033635464,
0.020956058,
-0.014715516,
-0.02248975,
-0.013069441,
-0.012276151,
0.0002956242,
0.0019435587,
-0.00010618507,
0.024036665,
0.02186834,
-0.024023443,
0.022740958,
0.0036491307,
0.0018824093,
-0.0018196072,
-0.029457474,
0.009638465,
-0.031123383,
-0.0019815704,
0.028241098,
0.016130215,
0.003784651,
-0.015931893,
-0.0065115825,
0.029642576,
-0.011185379,
0.0007069364,
0.0011213474,
-0.0021749348,
-0.007166046,
0.0035334425,
0.00023571434,
-0.027606467,
-0.01022021,
0.0057116826,
-0.024644854,
-0.0045977724,
-0.015958335,
0.015350147,
-0.015032832,
0.00062430213,
-0.0190125,
-0.010015277,
-0.0065347203,
-0.027712239,
-0.046380978,
0.010054941,
-0.019475251,
0.009056719,
-0.03432298,
-0.015865786,
-0.023402033,
-0.004373007,
-0.031652242,
-0.024287874,
0.01013427,
0.024591967,
-0.00546378,
0.019673575,
-0.015574913,
0.014213099,
-0.008607188,
0.031255595,
0.019700017,
-0.009664908,
0.021537803,
0.008322926,
0.017029276,
-0.0007945288,
-0.032392643,
-0.01004172,
0.029827677,
-0.01652686,
-0.013618132,
0.013347092,
0.01110605,
0.03189023,
-0.011667963,
0.020017333,
-0.01643431,
0.026019888,
0.015482362,
-0.017518472,
-0.0019336425,
-0.006524804,
-0.0040821345,
0.000072098424,
-0.015138604,
-0.02595378,
-0.013161991,
0.008732793,
-0.016302094,
-0.05225132,
0.012388534,
-0.014728737,
0.0067760125,
0.010365646,
-0.00011661765,
0.019250486,
0.014014777,
-0.001389909,
-0.020228876,
-0.030594522,
-0.031096939,
-0.0076552415,
0.0016386381,
-0.01680451,
-0.015085718,
0.006994167,
-0.0021980724,
-0.02346814,
-0.001626243,
-0.0222121,
-0.033344593,
-0.020361092,
-0.0062140995,
0.010722627,
-0.012210044,
0.0061116326,
-0.020480085,
-0.018867062,
-0.017359814,
0.018708406,
-0.011119272,
-0.0191976,
0.012507527,
0.0024972085,
-0.022859953,
0.013128937,
-0.020519748,
0.019951224,
-0.0030673852,
0.0033086773,
0.18816821,
-0.020215655,
-0.032154657,
0.032630634,
-0.008732793,
-0.014556858,
0.0188274,
0.0014163519,
-0.011072996,
0.0013651187,
-0.011456419,
-0.007635409,
-0.017095383,
0.002746764,
0.007311483,
-0.002794692,
-0.014318871,
-0.016857397,
-0.021736126,
0.013591689,
0.021577468,
-0.009274874,
0.003867285,
-0.0033169407,
0.041065942,
-0.022436865,
-0.018562969,
0.001281658,
0.01297689,
0.022555858,
-0.041092385,
0.019316593,
0.0054042833,
-0.011132493,
-0.007000778,
0.001994792,
-0.0079130605,
0.0174127,
-0.008554302,
-0.02648264,
-0.023521027,
-0.007536248,
-0.03191667,
0.0060884953,
0.0027351952,
0.026601633,
0.0071792677,
-0.01661941,
0.005278679,
0.01733337,
-0.01537659,
0.015773235,
-0.008375812,
0.034349427,
-0.01812666,
-0.0022592216,
0.014808066,
-0.0006462002,
-0.009089773,
0.029457474,
-0.023137603,
-0.0049745846,
-0.021286596,
0.025821567,
-0.021154381,
0.041885674,
-0.0015783152,
-0.0028541887,
0.026799956,
-0.024777068,
0.01226293,
0.0013618133,
-0.02604633,
-0.007192489,
-0.011687796,
-0.023745792,
0.026945392,
0.024406867,
0.03474607,
0.048469976,
0.00657769,
-0.011396922,
-0.015773235,
-0.00057926646,
0.028452642,
-0.040325537,
0.028849287,
-0.008547692,
-0.028320426,
-0.024658075,
0.020810623,
-0.0053183436,
-0.017901894,
-0.009942559,
0.018880285,
-0.004515138,
-0.017108604,
-0.020056996,
-0.009816955,
0.010848231,
-0.047042053,
0.069439255,
-0.0034607244,
0.0355658,
0.0015865786,
0.016698739,
-0.020585857,
-0.0087989,
0.0029632659,
-0.008627021,
0.008375812,
-0.015006389,
0.023309482,
-0.00020245403,
0.00612816,
0.012573635,
0.030885395,
-0.0355658,
0.039241377,
-0.001257694,
-0.019118272,
-0.038659632,
0.016817732,
0.02808244,
-0.014675852,
-0.0040920503,
-0.0016708656,
0.0046242154,
-0.012646353,
-0.036729295,
-0.0031797679,
-0.0072189323,
0.009056719,
0.0032706656,
0.016513638,
-0.018245652,
0.0015179921,
-0.0046076886,
-0.02452586,
0.015403033,
-0.0005718293,
-0.009347592,
0.0118927285,
0.0065181935,
0.0019435587,
-0.008032054,
0.008984001,
0.02808244,
-0.005014249,
-0.026852842,
-0.0066966834,
0.006270291,
0.00042432713,
0.008131215,
0.009823565,
-0.023256596,
0.019541359,
-0.05135226,
0.000556542,
-0.005067135,
-0.039029833,
0.010266486,
0.0113242045,
-0.00068958325,
0.0036623522,
0.00951286,
-0.16479263,
0.013188434,
-0.003688795,
-0.016659075,
0.028055998,
0.038368758,
-0.0036458252,
-0.006815677,
-0.0041350205,
0.0031351454,
0.027011499,
0.013975113,
-0.031678684,
-0.018999279,
0.026469419,
-0.016844176,
-0.014530415,
0.030277207,
0.03635909,
0.015429476,
0.020546192,
-0.035169158,
0.007635409,
-0.007258597,
0.009757458,
0.02008344,
0.007985779,
-0.012567024,
0.00870635,
-0.0042507085,
0.00043424324,
-0.0024079634,
0.03921493,
-0.024591967,
0.0069809454,
0.0051596854,
0.009916116,
-0.031149825,
0.0017353203,
-0.004406061,
0.03813077,
0.022410423,
-0.011720849,
0.0024558913,
-0.004531665,
0.010967224,
-0.01820599,
-0.03128204,
0.024962168,
-0.0035334425,
0.011899339,
0.004505222,
0.017201155,
0.020532971,
0.025305927,
-0.012362091,
0.0040358594,
0.015151825,
-0.01573357,
0.0028674102,
-0.004363091,
-0.0067958445,
0.01652686,
-0.0062174047,
0.0059298375,
-0.012937225,
-0.015217933,
0.020691628,
-0.026826398,
0.0055067497,
0.0013915616,
-0.02586123,
0.0008957558,
-0.009473196,
0.020056996,
0.024869619,
-0.023864785,
0.020043775,
-0.0052555413,
0.003847453,
-0.022172434,
0.0144246435,
-0.015178268,
-0.03641198,
-0.009671519,
-0.019673575,
-0.01865552,
0.00012085266,
-0.007456919,
-0.0010593717,
0.02346814,
-0.011952225,
-0.010643298,
-0.018443976,
0.043578025,
0.019078607,
-0.005629048,
-0.006699989,
-0.026720626,
-0.020056996,
0.025543915,
-0.02639009,
-0.007066885,
-0.008349369,
0.054049443,
0.024750626,
-0.018364647,
0.016315317,
0.04373668,
-0.006746264,
0.006055441,
0.002695531,
0.016090551,
0.023560692,
0.00043796177,
0.032577746,
0.0015072497,
-0.013406589,
0.001231251,
-0.018510083,
0.06732382,
-0.008984001,
-0.0018642298,
0.0067132106,
-0.030991167,
0.0015981473,
-0.12544547,
0.017690351,
0.014834509,
0.022992168,
-0.019237265,
0.014503972,
-0.019250486,
0.03440231,
-0.00852786,
0.031784456,
-0.024420088,
-0.008131215,
-0.012130715,
-0.0011626646,
-0.021220488,
0.020506527,
0.014808066,
-0.006247153,
-0.018853841,
0.030673852,
0.019157935,
-0.0034937782,
-0.005272068,
-0.0382101,
0.018258875,
0.012322427,
-0.037416812,
0.017187934,
0.024552302,
0.013512361,
-0.005741431,
-0.025755458,
0.006174435,
-0.004815927,
-0.010180546,
-0.010021888,
0.01652686,
-0.023031833,
0.03305372,
0.0025616633,
-0.0055728573,
0.0015560038,
-0.013320649,
-0.0053381757,
-0.00359955,
-0.0087658465,
-0.018179545,
-0.022899617,
0.015680684,
-0.011396922,
-0.016209545,
-0.024922505,
-0.027818011,
-0.008051886,
0.012798401,
-0.0076816846,
0.020374313,
0.013922227,
-0.016751625,
0.004422588,
0.010676351,
0.0049514472,
-0.004095356,
0.009281484,
0.020678407,
-0.007523027,
0.00016351262,
-0.010385479,
0.030012777,
-0.042864062,
0.0029599606,
-0.00215345,
-0.036279764,
0.007965947,
-0.026522305,
-0.0040127216,
-0.03011855,
-0.02070485,
-0.011800178,
-0.02222532,
-0.0011585329,
-0.015429476,
0.000021136304,
-0.015852563,
0.023481362,
0.0036557415,
-0.007846953,
-0.0067132106,
0.007833731,
-0.0020642048,
0.006600828,
0.049580578,
-0.00039643806,
-0.021365924,
-0.0069346703,
0.008349369,
-0.0013147116,
0.0044920007,
0.003678879,
0.02533237,
-0.016738404,
-0.0016229376,
-0.05775146,
0.01804733,
-0.00004550051,
-0.0076816846,
0.01884062,
-0.019951224,
0.008957558,
0.01705572,
-0.027421366,
0.015059275,
0.007238765,
0.004941531,
-0.007926282,
0.0050274706,
-0.031149825,
-0.011575413,
0.0031880313,
0.0034904727,
0.017386256,
0.03561869,
0.013406589,
-0.013671018,
0.027209822,
0.028188212,
-0.012190212,
0.002105522,
-0.02683962,
0.0053613135,
-0.02007022,
0.0110002775,
0.009288095,
-0.013803233,
-0.015429476,
-0.007668463,
0.0028277456,
-0.00790645,
-0.015945114,
0.025557136,
-0.0066867676,
0.04415977,
0.00010556532,
-0.0323662,
0.008065107,
0.006888395,
-0.0077081276,
0.0040556914,
-0.04014044,
0.010577191,
0.010583801,
0.0074436977,
0.028902173,
0.029245932,
0.023957336,
-0.015442697,
0.014715516,
-0.002173282,
0.01652686,
0.003206211,
0.004498611,
-0.021802234,
0.010008667,
0.038633186,
0.016275652,
0.006283512,
-0.021524582,
0.017822566,
-0.024155658,
-0.009208766,
0.009030276,
-0.02149814,
-0.01839109,
0.022185657,
0.006809066,
0.006346314,
-0.014292428,
0.012157158,
-0.012844675,
0.00582076,
-0.016698739,
0.022569079,
0.0045283595,
-0.017452365,
0.0034342816,
-0.013175213,
0.03083251,
-0.010881284,
-0.006861952,
0.0116084665,
-0.0013056219,
0.016460752,
-0.012957058,
0.011786956,
0.00012766999,
-0.005873646,
-0.0174127,
0.027606467,
-0.0057116826,
0.024591967,
-0.00034561797,
0.0132875955,
-0.004822538,
-0.011899339,
-0.008990612,
0.0033235515,
-0.018007666,
0.01564102,
-0.0005437337,
-0.021352703,
-0.013426421,
0.0048357593,
0.011582023,
0.008812122,
0.017478807,
-0.005751347,
-0.025821567,
-0.003500389,
-0.0015568301,
0.0044126716,
-0.008871619,
0.009433531,
-0.0004420935,
0.021299817,
0.013452864,
0.0155616915,
0.030224321,
0.0052158767,
0.022793844,
-0.0053613135,
0.029272374,
0.0011833232,
-0.001004833,
0.011747292,
-0.0012659575,
-0.0050968835,
-0.0030706904,
0.0011734071,
0.0011279582,
0.011456419,
-0.008124604,
0.07811255,
0.019157935,
-0.036649965,
-0.0023137603,
-0.006293428,
0.026892506,
0.02533237,
0.011429977,
-0.02185512,
-0.025808344,
0.016368201,
-0.028690629,
0.005351397,
-0.030065663,
-0.032181103,
0.042599633,
-0.012375313,
-0.0005185302,
0.015059275,
-0.0050043333,
0.008474974,
-0.041859232,
0.0013155381,
0.008554302,
-0.022542637,
0.0071594357,
0.016963169,
0.020215655,
-0.027870897,
0.003910255,
0.00599925,
-0.034084994,
-0.0318109,
0.020757737,
0.00032516598,
-0.0031500196,
-0.013763568,
-0.031440698,
0.037892785,
0.00047060233,
-0.0021435337,
-0.0072652074,
-0.0018609244,
-0.007027221,
0.014689073,
0.003430976,
0.012785179,
-0.021313038,
-0.015429476
] |
Overexpression of the proto-oncogene bcl-2 promotes abnormal cell survival by inhibiting apoptosis. Expression of bcl-2 is determined, in part, by regulatory mechanisms that control the stability of bcl-2 mRNA. Elements in the 3'-untranslated region of bcl-2 mRNA have been shown to play a role in regulating the stability of the message. Previously, it was found that the RNA binding proteins nucleolin and Ebp1 have a role in stabilizing bcl-2 mRNA in HL60 cells. Here, we have identified HuR as a component of bcl-2 messenger ribonucle | [
-0.044936836,
-0.026988227,
0.0025342284,
-0.021854455,
-0.0117044775,
0.0005821214,
-0.007432866,
0.018680139,
-0.005094583,
-0.00046292125,
-0.012233531,
-0.011782856,
0.010509211,
0.0077986307,
-0.013794563,
-0.0033016817,
0.018915271,
-0.010182635,
0.01537519,
0.017308518,
-0.01683825,
0.024649944,
-0.027981017,
-0.023356704,
-0.011377902,
-0.0012254758,
0.015035551,
-0.03328461,
0.020744096,
-0.030227859,
0.010052004,
0.021593194,
-0.022990938,
-0.0067078676,
-0.018667074,
-0.009529483,
0.013742311,
-0.008680386,
0.006231067,
-0.0004169965,
0.037308022,
0.002795489,
0.005590978,
0.014304021,
-0.005953477,
0.0006204941,
0.013187132,
-0.007988045,
-0.013356952,
0.02583868,
0.008987367,
0.018706264,
-0.027589126,
-0.019359415,
-0.0010058535,
-0.003579271,
-0.010143446,
0.040939547,
-0.005016205,
0.0044120396,
0.00106627,
-0.015610325,
-0.009359663,
0.0052121505,
-0.0070148488,
0.017125636,
0.012742989,
0.00038842112,
0.014774291,
0.0005568118,
0.03260533,
0.033101726,
-0.009111466,
0.014147265,
0.0077333157,
-0.025590483,
-0.03122065,
0.021410313,
0.00034821147,
0.0042128284,
0.014695913,
-0.0061167656,
0.012213936,
-0.0024983052,
0.025329221,
-0.0142517695,
-0.018079238,
-0.010770471,
-0.009157186,
0.0002539127,
0.030645875,
0.013187132,
0.009261691,
0.016903564,
-0.011789388,
0.004255283,
-0.0016108353,
0.042689994,
0.012416413,
-0.03527019,
-0.003742559,
-0.0017684081,
-0.03242245,
-0.0023007267,
-0.023631027,
0.0034225148,
-0.0036837754,
-0.025198592,
0.012651548,
0.001134851,
-0.022821119,
0.027014352,
-0.0045687957,
-0.026034625,
0.051990874,
-0.018118428,
-0.0012360895,
0.012181278,
-0.005538726,
-0.009960563,
0.009712365,
0.01856257,
-0.00028350865,
-0.039450362,
0.018222932,
-0.0008315437,
-0.017491402,
-0.0050749886,
0.003527019,
0.0058293785,
0.01257317,
0.024297241,
-0.014839605,
0.00075561483,
-0.020273827,
-0.002677922,
-0.0058065183,
-0.03884946,
0.010261012,
-0.015061677,
0.011306055,
0.03341524,
-0.010777002,
0.0020035428,
-0.00008445047,
0.0018288246,
0.01666843,
0.017935544,
0.003513956,
0.016851313,
-0.005378704,
-0.018549507,
0.025250843,
-0.020273827,
0.011443217,
0.017426087,
-0.013637807,
0.039972883,
-0.0023693077,
-0.0360801,
0.020104008,
-0.01421258,
0.012161684,
0.02368328,
0.028686421,
0.020717971,
-0.008072955,
0.0030191937,
-0.010705156,
0.013043439,
0.016185097,
0.021985086,
-0.023069317,
0.016746808,
-0.01421258,
0.0030616485,
-0.00977768,
0.03412064,
-0.009346601,
-0.004297738,
-0.024872016,
0.012769115,
0.023905352,
0.005757532,
-0.012821367,
0.007380614,
0.021475626,
-0.016198162,
0.004702692,
-0.0058424417,
-0.0023154228,
0.010326328,
0.024780573,
-0.0040070857,
-0.63664,
-0.028947681,
0.0040462743,
-0.0038046085,
-0.006851561,
0.020130135,
0.012168216,
-0.005048862,
-0.029522456,
0.030044977,
-0.02032608,
0.017086448,
0.010476553,
-0.022690488,
-0.013441862,
-0.04436206,
-0.012390287,
-0.029496329,
0.024467062,
-0.022794994,
-0.011404028,
0.013467987,
-0.025655797,
0.021867517,
-0.008889394,
0.025512105,
0.0220504,
-0.028085522,
-0.0074393973,
0.021423375,
0.0010801496,
0.037621535,
0.0036968384,
0.0024623817,
0.04417918,
-0.0019643537,
-0.00004702182,
0.017582843,
0.021488689,
0.02041752,
0.0035988656,
-0.0047876015,
0.022494543,
-0.0032379993,
-0.011606505,
0.009921374,
0.014839605,
0.009078808,
0.012155153,
0.0014875529,
-0.0006609078,
0.015296812,
-0.019215722,
-0.007204263,
-0.011573847,
0.008850205,
0.025290033,
-0.04117468,
0.007001786,
-0.012847493,
-0.008471377,
0.009098403,
-0.015754018,
-0.017256267,
-0.011939612,
0.0064662015,
-0.030044977,
0.010803129,
0.004862714,
0.019620676,
0.01873239,
0.01770041,
-0.003850329,
-0.0022223485,
0.003270657,
0.05013592,
-0.010646372,
-0.0046406426,
0.011939612,
0.019712117,
-0.0046275794,
-0.0025146338,
-0.036367483,
0.0040854635,
0.02053509,
0.007498181,
-0.019372478,
0.021279681,
0.003107369,
-0.0031269635,
0.003458438,
0.011998396,
-0.010966416,
-0.022507606,
-0.013742311,
0.038614325,
-0.0029538784,
0.00035004847,
0.020260764,
-0.0318738,
-0.0033229091,
-0.009699302,
0.00084256567,
0.02092698,
0.018549507,
-0.0034290461,
-0.032161187,
0.011175425,
0.028137773,
-0.009424979,
0.010554931,
0.013494113,
0.007661469,
-0.031664792,
-0.005065191,
-0.02510715,
0.030306237,
0.02182833,
-0.010881507,
-0.05418546,
0.017752662,
-0.00041128145,
0.0064988593,
-0.024689132,
0.005741203,
0.013317763,
0.011697946,
0.00026860862,
0.009705834,
-0.011763262,
0.012912808,
-0.01408195,
0.041671075,
-0.02398373,
0.03613235,
-0.0059894007,
0.023591839,
0.020012567,
0.006799309,
-0.015087804,
-0.038274687,
-0.0044936836,
0.029052187,
-0.0034029202,
-0.011123173,
-0.018706264,
-0.008210116,
-0.015283749,
0.022076527,
0.009340069,
0.0067339935,
-0.002516267,
-0.0036151945,
0.011136236,
0.025917059,
-0.009255159,
-0.017308518,
-0.017125636,
-0.027353993,
-0.023565711,
0.0056399647,
0.0026550614,
0.0069756596,
0.022808056,
-0.0048104622,
-0.0023268529,
0.023239136,
0.0115020005,
-0.0044153053,
-0.04595575,
-0.011920018,
0.00676012,
-0.016746808,
0.0010523907,
0.020704908,
0.005163164,
-0.01717789,
0.00035494711,
0.007432866,
-0.0046830974,
-0.00088583695,
-0.009366195,
-0.015309875,
-0.0226513,
0.014499967,
0.021397248,
0.018170679,
0.012063711,
0.019868873,
0.00710629,
-0.008706512,
0.01980356,
-0.0015324571,
0.036890008,
-0.0013952953,
-0.016563926,
0.014917984,
0.010574525,
0.01877158,
0.017622031,
0.017687347,
-0.003850329,
-0.00094380416,
-0.012560107,
-0.0016451258,
-0.01950311,
-0.0012720128,
-0.006270256,
-0.0079423245,
0.017674284,
-0.002717111,
0.0046798317,
0.0039515677,
-0.019085092,
0.0036772438,
0.008301558,
-0.0041311844,
0.0028216152,
-0.0102479495,
-0.008379936,
0.0027530342,
0.007635343,
0.00900043,
0.008046828,
-0.0057771266,
-0.0035727397,
0.019960314,
0.00770719,
0.019072028,
0.0054570823,
-0.008954709,
0.006812372,
0.0115020005,
-0.002054162,
-0.0011519962,
-0.0011038263,
0.015349064,
-0.021005357,
0.0422981,
-0.008804484,
-0.020143198,
0.009594798,
-0.010992543,
0.01743915,
0.016394107,
-0.008582413,
0.011730604,
0.004418571,
-0.004108324,
0.0043565216,
-0.0055615865,
0.019947251,
-0.017034195,
0.014787354,
0.0003069813,
-0.008190522,
0.001850052,
0.015153118,
0.06688273,
0.006270256,
0.032448575,
-0.013193663,
0.0037490905,
-0.008027234,
0.008608539,
-0.0021586663,
0.0031596213,
-0.008713043,
-0.0077659735,
0.0007641874,
-0.029235069,
0.0021423374,
0.014695913,
-0.038144056,
0.02829453,
0.012586232,
0.0022778665,
0.035714332,
0.007890072,
0.020090945,
-0.022690488,
-0.020286892,
0.042611614,
0.03435578,
-0.019816622,
-0.0055746497,
-0.053558435,
0.0064531383,
-0.013036908,
0.008079486,
0.00853016,
0.00022717431,
-0.001587975,
0.005744469,
-0.0048855743,
0.00475821,
0.015022488,
-0.022011211,
0.028372908,
-0.012155153,
0.021540942,
-0.008131738,
-0.014486904,
0.024088234,
0.045589987,
-0.0011177058,
0.019045902,
-0.009653581,
0.0025603545,
-0.014735102,
-0.017961672,
-0.02777201,
0.0057052798,
-0.01976437,
-0.010117319,
-0.0074655237,
0.027693631,
0.020143198,
0.013428798,
0.01826212,
-0.024427872,
-0.008490971,
-0.0014900023,
0.0005682419,
0.034094516,
0.019111218,
0.0023154228,
0.024297241,
-0.00036433616,
0.02803327,
-0.02079635,
-0.028190026,
0.017935544,
-0.015688702,
-0.00084828073,
-0.01171101,
-0.018706264,
-0.0062767877,
-0.009993221,
0.0048431195,
0.0089743035,
-0.03686388,
0.015218434,
-0.003028991,
0.0058848965,
0.006080842,
0.009111466,
0.04483233,
0.006988723,
0.017047258,
-0.015113929,
0.030306237,
0.013977446,
-0.001478572,
0.01709951,
0.012292314,
0.010646372,
0.012631953,
0.010182635,
-0.017151764,
0.0127756465,
0.013076097,
0.005672622,
0.0022501075,
0.025551293,
0.019320227,
0.010398175,
-0.013285105,
-0.010391643,
-0.027118858,
0.005202353,
0.015362127,
-0.006825435,
-0.019019777,
0.0066000978,
-0.013886005,
-0.026322013,
-0.027928766,
0.000106239204,
-0.002565253,
-0.0071520107,
0.010058535,
0.013938257,
-0.018640948,
-0.0061559547,
-0.013272041,
0.034773793,
0.0048692455,
0.0260085,
-0.022455355,
-0.020979231,
-0.007661469,
-0.011913487,
-0.019019777,
0.004768007,
-0.024362557,
-0.026909849,
0.0057510003,
0.0036641809,
0.02454544,
0.009098403,
-0.010261012,
0.0024770778,
0.01666843,
0.000986259,
-0.012442539,
0.030253986,
-0.046713408,
0.0071781366,
-0.010933759,
0.011266867,
-0.023840036,
-0.015035551,
-0.0072107944,
-0.015963027,
-0.007197731,
0.016785998,
-0.009072277,
0.0004959871,
0.014016635,
0.020744096,
0.0354792,
0.0137161845,
0.0043010036,
0.008895925,
-0.010613714,
-0.03289272,
-0.005960009,
-0.0059077567,
-0.010620246,
-0.0034127175,
0.015061677,
-0.0109860115,
0.008360341,
0.01916347,
-0.00040311704,
-0.0029391826,
0.009784212,
-0.00045475684,
0.021292744,
0.004189968,
0.016172035,
0.018026985,
-0.0078312885,
-0.013807626,
-0.029313447,
0.026988227,
-0.008634665,
-0.001730852,
0.0018043314,
-0.007850883,
-0.022128778,
-0.01257317,
-0.0022990939,
-0.0117044775,
0.03506118,
0.019490046,
-0.016681494,
-0.03061975,
0.0026909849,
-0.009836464,
0.001987214,
-0.020299954,
-0.026243635,
-0.018745452,
0.0032739227,
0.0032886188,
-0.004320598,
0.014617534,
-0.025028773,
-0.0018941398,
0.041488193,
0.015126993,
-0.017086448,
-0.0018843425,
-0.008549755,
-0.03200443,
-0.0006715215,
-0.011384433,
-0.016002215,
0.011221145,
-0.012364161,
0.047706198,
0.013755374,
0.03911072,
0.010626778,
0.017883293,
0.028634168,
0.020090945,
0.00835381,
-0.014708975,
0.0019349618,
-0.010006283,
0.0070213806,
-0.007119353,
0.0079423245,
0.028111648,
-0.029287321,
-0.0010989277,
0.015845459,
0.004287941,
0.00153409,
0.0009895248,
-0.03234407,
-0.05836563,
0.011390965,
-0.024728322,
0.005372172,
-0.032448575,
-0.013415735,
0.0036968384,
-0.00035025258,
0.008288494,
-0.0096209245,
0.001621449,
-0.020378333,
-0.00015726668,
-0.0033702627,
-0.00904615,
-0.0032820872,
0.0069430023,
0.004715755,
-0.0012654813,
0.014173391,
-0.00064253795,
0.021109862,
-0.005646496,
-0.026805345,
-0.011822045,
0.009895247,
-0.019960314,
-0.020077882,
0.005770595,
0.0034355777,
-0.010822723,
-0.018536445,
-0.0047484124,
-0.028503539,
0.013637807,
0.023252198,
-0.0015324571,
0.020273827,
0.0025668861,
-0.015910774,
0.021841392,
-0.013056502,
0.02347427,
-0.0047941334,
0.019934189,
0.021567067,
-0.0006098804,
-0.019267974,
-0.010483084,
-0.00047312674,
0.008425657,
0.02135806,
0.025668861,
-0.016890502,
-0.009313943,
0.009529483,
0.024049044,
-0.016563926,
-0.03764766,
0.012331503,
-0.02415355,
-0.008334215,
0.0013838651,
-0.0248067,
-0.0045361384,
-0.0021929566,
-0.0012997718,
0.020286892,
-0.019254912,
-0.009477231,
0.011279929,
0.013167538,
-0.00788354,
0.0015536845,
0.0011209715,
-0.02079635,
-0.010639841,
-0.01955536,
0.002485242,
-0.018719327,
-0.022703553,
0.038509823,
-0.007485118,
-0.013298168,
0.01494411,
-0.004431634,
0.0015283749,
-0.01942473,
-0.0058032526,
0.03459091,
-0.025917059,
-0.012958529,
0.009738491,
-0.01541438,
-0.0003757663,
-0.009914842,
-0.0030208265,
-0.019633738,
-0.019437794,
-0.0009723795,
0.01847113,
0.03135128,
0.0043303957,
-0.0010164672,
-0.01468285,
-0.00956214,
-0.025721112,
-0.032056686,
-0.0055713835,
-0.043813415,
-0.007890072,
-0.02782426,
0.02403598,
0.022690488,
0.0045426697,
-0.0040854635,
-0.010241418,
0.03777829,
-0.010319796,
0.014526093,
-0.010261012,
-0.022507606,
-0.016302666,
0.0004559815,
-0.021867517,
-0.019908063,
0.014617534,
-0.0155972615,
-0.01946392,
-0.023043191,
-0.039502613,
0.03892784,
0.037360277,
-0.024022918,
0.008752232,
-0.0024117625,
0.007295704,
-0.010084662,
-0.00034984437,
0.01481348,
-0.0090853395,
0.016119784,
0.012801773,
-0.009607861,
-0.009117997,
-0.007903135,
-0.004281409,
-0.009862591,
-0.006162486,
-0.018053113,
-0.014865732,
0.0007307134,
-0.010966416,
-0.00078255736,
-0.009810338,
0.009170249,
-0.0027383384,
0.020979231,
-0.00086052733,
0.014774291,
-0.021932833,
0.0037915455,
0.0155972615,
0.009451104,
-0.031272903,
-0.020508962,
-0.01119502,
-0.02730174,
-0.0151923075,
0.00013236527,
-0.008732637,
0.026034625,
0.0005282364,
-0.020077882,
-0.015989153,
-0.0015234762,
-0.04441431,
0.0038307344,
0.006162486,
0.016472485,
-0.0019823152,
0.019973379,
-0.014186454,
-0.0011462811,
-0.0035074244,
0.018536445,
0.029809842,
-0.03419902,
-0.008288494,
-0.014199518,
-0.0018059644,
0.016877439,
-0.023095442,
-0.012044117,
0.04059991,
-0.01717789,
-0.030018851,
0.02842516,
-0.035374694,
0.008086017,
-0.013343888,
-0.0028150836,
0.003406186,
0.015884649,
0.011247272,
-0.041096304,
0.00006643777,
0.018405814,
0.0030044976,
-0.038091805,
0.013846816,
0.0059665404,
0.021227429,
-0.0058293785,
-0.019346353,
-0.022233283,
0.010783534,
-0.0022386773,
0.00079317106,
0.032030556,
0.01365087,
0.04018189,
-0.0060220584,
-0.017687347,
-0.024989583,
0.0020019098,
-0.016433297,
0.0012483362,
0.014003572,
0.0045492016,
-0.014290959,
-0.01080966,
-0.014774291,
-0.022194093,
-0.012912808,
0.00005801824,
-0.017582843,
-0.0421936,
0.00025289215,
-0.0019104687,
-0.013167538,
-0.02497652,
-0.0069364705,
-0.028242279,
-0.021893645,
0.005094583,
-0.021397248,
-0.0002312565,
0.010221823,
-0.019490046,
0.017556718,
-0.0030763443,
-0.0018729124,
-0.016825186,
-0.006606629,
0.016054468,
0.18883921,
-0.021344997,
-0.016877439,
-0.000028090624,
-0.009274754,
-0.027066605,
0.002338283,
-0.006495593,
-0.001552868,
-0.00039719784,
0.0022256144,
0.007543902,
-0.011188488,
0.004594922,
0.01753059,
-0.009784212,
-0.022625174,
-0.008556287,
-0.023408955,
0.010757408,
0.0061951433,
-0.012259657,
0.022925623,
-0.002258272,
0.04276837,
0.0076288115,
-0.041409817,
0.021162113,
0.010822723,
-0.0064335437,
-0.031246776,
-0.012677674,
0.0053329836,
0.0067797145,
0.010084662,
0.0068972814,
-0.020913916,
0.0036413206,
-0.018170679,
-0.013833752,
-0.008014171,
0.003716433,
-0.00046088014,
0.0026534286,
0.03161254,
0.0009340069,
-0.012377224,
-0.016472485,
-0.015349064,
-0.003690307,
-0.031664792,
0.019738244,
0.01421258,
0.03540082,
-0.007974982,
0.013428798,
0.013232852,
0.0025701518,
0.009581735,
0.011221145,
-0.010848849,
0.004160576,
-0.04023414,
0.0092878165,
-0.013676996,
0.03459091,
0.005071723,
-0.00086950813,
0.02394454,
-0.03014948,
0.022376977,
0.007380614,
-0.02002563,
0.004634111,
-0.004323864,
-0.0029653085,
0.011482406,
0.022925623,
0.019986441,
0.030253986,
-0.008438719,
0.015231497,
-0.05507375,
-0.010443895,
0.00613636,
-0.04083504,
0.020574277,
0.00084991363,
-0.0055126,
-0.026648588,
0.021240491,
-0.008327683,
-0.009888716,
0.006511922,
0.027118858,
0.005607307,
-0.0020639594,
0.017726537,
-0.02704048,
-0.013063033,
-0.025721112,
0.07639262,
0.010287139,
0.020443646,
0.0052937944,
-0.01205718,
0.00088338763,
-0.0022125512,
-0.0025619874,
-0.014134202,
0.014774291,
-0.030515246,
0.008778359,
-0.010901101,
-0.007256515,
0.009914842,
0.020273827,
-0.013108754,
0.0293657,
-0.021580132,
-0.016381044,
-0.019672928,
0.0104700215,
0.046321515,
-0.0017847369,
0.022729678,
-0.017582843,
0.006260459,
-0.020090945,
-0.025002645,
0.027484622,
0.0054636137,
-0.022755804,
0.005283997,
0.013324294,
0.004732084,
0.008850205,
-0.019372478,
-0.016106721,
0.011874298,
-0.025525168,
-0.016851313,
-0.009660114,
0.008157864,
0.004173639,
-0.009653581,
0.011423622,
0.001019733,
-0.009666645,
0.009555609,
-0.0009152288,
-0.021671573,
-0.030541372,
-0.015636452,
0.0122400625,
-0.011789388,
-0.030854885,
-0.030854885,
0.009072277,
0.017582843,
-0.03446028,
0.015845459,
0.012468665,
-0.018510317,
0.011671821,
-0.003107369,
-0.16365369,
0.01421258,
0.008680386,
-0.043003507,
0.026295885,
0.0109860115,
-0.014708975,
-0.021958958,
-0.033441365,
0.019790495,
0.018353561,
0.0073218304,
-0.043526027,
-0.04182783,
0.0016230819,
-0.017935544,
0.015322938,
0.029600833,
0.027798135,
0.00035515122,
0.023278326,
-0.0049639526,
0.029992724,
-0.01800086,
-0.016864376,
0.014499967,
0.0038601262,
-0.019006714,
-0.004526341,
-0.002797122,
-0.014970236,
0.011939612,
-0.0013593719,
-0.010489616,
0.008007639,
0.010195698,
-0.021227429,
-0.006204941,
0.0012916074,
0.030854885,
0.023304451,
0.03811793,
-0.019868873,
0.022259409,
-0.0000952683,
0.05042331,
0.015140056,
-0.0015324571,
0.015309875,
0.0057771266,
0.016851313,
-0.006678476,
0.022625174,
0.0067078676,
0.0017471807,
-0.004203031,
-0.0030796102,
0.025316158,
-0.00025309628,
0.009366195,
0.014552219,
-0.02967921,
0.033859383,
0.004078932,
0.0032820872,
-0.022690488,
-0.0073218304,
0.03014948,
-0.02574724,
-0.0023986995,
-0.018549507,
0.004323864,
0.023813909,
-0.027144983,
0.013187132,
0.02493733,
0.0017847369,
0.025995437,
-0.0052546053,
0.0076288115,
-0.001729219,
0.012161684,
-0.019607613,
-0.014160329,
-0.010215292,
-0.012899745,
0.0040919953,
0.030227859,
-0.013886005,
-0.018157616,
0.011952676,
-0.0038078742,
-0.0034878298,
0.006649084,
0.02178914,
0.014499967,
0.0046243137,
-0.0073610195,
0.000739286,
-0.008673854,
0.012742989,
-0.020744096,
-0.019516172,
-0.004663503,
0.041462068,
0.0022337786,
0.0024966723,
-0.003012662,
0.052565645,
-0.009549078,
-0.004986813,
0.005313389,
0.014904921,
0.011175425,
-0.004346724,
0.006956065,
0.014996362,
-0.01248826,
-0.010143446,
-0.029287321,
0.07299623,
0.010143446,
-0.015283749,
0.007857415,
-0.00853016,
-0.032030556,
-0.116940275,
-0.02244229,
0.02855579,
0.020639593,
-0.018745452,
0.030018851,
-0.0045589986,
0.03182155,
-0.015636452,
0.03725577,
-0.023696342,
0.004176905,
-0.0018827097,
0.0023807378,
0.015349064,
0.007067101,
0.019111218,
0.0074263345,
-0.006714399,
0.030645875,
-0.009660114,
-0.009816869,
-0.0140296975,
-0.011077452,
0.019934189,
-0.02041752,
-0.024179675,
-0.0073479563,
0.007929261,
0.020430584,
-0.010816191,
0.0018598493,
0.015179245,
0.0058130496,
-0.019516172,
-0.01938554,
-0.016851313,
-0.011880829,
0.034094516,
-0.013481051,
0.0060449187,
0.007981514,
0.007001786,
-0.018144554,
-0.0065478454,
-0.034303527,
-0.02988822,
-0.0096209245,
-0.0077920994,
0.002984903,
-0.026935974,
-0.018484192,
-0.017622031,
-0.008804484,
0.026517957,
-0.004232423,
0.018079238,
0.043055758,
-0.0177396,
0.0078051626,
0.013833752,
0.008464846,
-0.016563926,
0.00021594827,
0.02079635,
-0.008464846,
-0.007243452,
-0.034982804,
0.028216152,
-0.027798135,
0.001391213,
0.00891552,
-0.013206727,
-0.004637377,
-0.025054898,
-0.0006498859,
-0.028059395,
-0.015100867,
0.0067405254,
-0.009451104,
-0.014735102,
-0.016563926,
0.03560983,
-0.025995437,
0.02308238,
-0.004836588,
0.007576559,
-0.020090945,
0.014735102,
-0.0046569714,
0.012560107,
0.057895362,
-0.0068450295,
-0.011149299,
0.0046961606,
-0.0039940225,
-0.018340498,
-0.008281963,
0.011090515,
-0.00079153816,
-0.0047941334,
0.0014940845,
-0.06150076,
0.010914165,
-0.013533303,
-0.0028869302,
0.010528805,
-0.011116642,
0.0052742,
-0.019490046,
-0.010182635,
-0.00067723665,
0.00006317201,
0.016576989,
0.001892507,
-0.011364839,
-0.015727893,
0.0058424417,
0.020548152,
-0.024898142,
0.019725181,
0.026609398,
-0.005675888,
-0.02647877,
-0.0072369203,
0.01184164,
0.0072107944,
-0.019921126,
0.0035368162,
0.02036527,
-0.014121139,
0.001433668,
0.008830611,
-0.038875587,
-0.024558503,
0.0066588814,
-0.013389609,
-0.027380118,
0.002782426,
0.034773793,
0.045328725,
0.023565711,
0.002039466,
-0.0483071,
-0.00035106903,
0.012566638,
0.0057738605,
-0.0048725116,
-0.036419738,
0.006397621,
0.0067405254,
-0.036680996,
0.033519745,
0.014003572,
0.012259657,
-0.025198592,
-0.014225643,
0.014486904,
-0.020430584,
-0.025342284,
-0.036759377,
-0.015989153,
0.01753059,
0.014160329,
-0.00016481875,
0.013298168,
0.0073218304,
0.010901101,
-0.0046014534,
-0.005186024,
-0.010149977,
-0.035557576,
-0.015531947,
0.0007307134,
0.010313265,
0.007197731,
0.0103393905,
0.0062767877,
-0.037490904,
0.013964383,
-0.02514634,
0.005218682,
0.013337357,
-0.0023333842,
0.00740674,
0.010587589,
0.029130565,
0.017595906,
-0.008889394,
0.0040854635,
0.0006866257,
0.0015291914,
-0.015048615,
0.020247702,
-0.0014148898,
0.00059681735,
0.007099759,
0.03388551,
-0.024440935,
0.0018729124,
-0.019437794,
-0.0029832702,
-0.013161006,
0.0008621602,
-0.016185097,
-0.022494543,
-0.020104008,
0.021253556,
-0.024310306,
-0.0318738,
-0.0165378,
-0.009189844,
-0.0028542727,
0.014617534,
0.023617964,
0.0051794928,
-0.00990178,
0.009222502,
0.0023856366,
0.0014851036,
-0.00072336546,
0.02161932,
0.01976437,
0.015126993,
0.005688951,
0.0035564108,
-0.010372048,
0.007256515,
0.00969277,
-0.01391213,
0.026909849,
-0.038980093,
0.031325154,
-0.01847113,
-0.051442225,
-0.008850205,
0.0005886529,
-0.0040201484,
0.006956065,
-0.0048692455,
0.0008891027,
0.079841256,
0.014199518,
-0.029078312,
-0.00082868617,
-0.009784212,
0.040965673,
0.00052497064,
0.0027122123,
-0.014735102,
-0.029705338,
0.017556718,
-0.0117044775,
0.0026550614,
-0.048385475,
-0.019699054,
0.030175608,
0.0050455965,
0.0019235316,
-0.0070344433,
-0.005636699,
0.008673854,
-0.009927905,
0.01137137,
0.0106529035,
-0.050109796,
0.018183742,
0.027432369,
-0.0009789111,
-0.0024280914,
-0.015270686,
0.008850205,
-0.0106724985,
-0.029731464,
-0.006093905,
0.03513956,
-0.0066131605,
-0.013833752,
-0.019372478,
0.017282393,
0.022416165,
0.01235763,
0.00044740888,
0.005137038,
-0.018902209,
0.0140296975,
-0.01524456,
-0.0074393973,
0.006962597,
0.0002535045
] |
Traits such as clutch size vary markedly across species and environmental gradients but have usually been investigated from either a comparative or a geographic perspective, respectively. We analyzed the global variation in clutch size across 5,290 bird species, excluding brood parasites and pelagic species. We integrated intrinsic (morphological, behavioural), extrinsic (environmental), and phylogenetic effects in a combined model that predicts up to 68% of the interspecific variation in clutch size. We then applied the same species-level model to predict mean clutch size across 2,521 assemblages worldwide and found that it explains the observed eco-geographic pattern very | [
-0.01308339,
-0.0066005406,
0.024322944,
-0.03277059,
0.0013166755,
0.025735244,
0.0013027813,
0.0013101371,
-0.03052137,
-0.045821287,
-0.009434949,
0.013613002,
0.0062115043,
0.011298399,
0.0029537338,
0.003932863,
0.030495217,
0.002142969,
0.014423767,
-0.008486876,
-0.014711457,
0.038315173,
-0.02189065,
-0.017274521,
-0.021027576,
0.026114471,
0.0041878615,
-0.0116318595,
-0.0010829268,
-0.003272482,
0.014109923,
0.0091080265,
-0.023642948,
-0.029579837,
-0.052752018,
-0.017993748,
0.0043807453,
-0.03399981,
0.017052215,
-0.01805913,
0.0054628546,
0.014986072,
-0.012161472,
0.0016754715,
-0.005835545,
0.008009572,
-0.011821474,
-0.0010616769,
-0.014580689,
0.017470673,
0.006806501,
0.011161093,
-0.03836748,
0.0069372696,
-0.0169476,
0.00066078966,
0.00093417754,
0.0065220795,
0.042473614,
-0.028141385,
-0.009951483,
0.016176065,
-0.006633233,
0.005325548,
-0.01981143,
0.0047109355,
-0.0023996022,
-0.00038392819,
0.013874539,
0.025447553,
0.026389087,
0.029998297,
0.013626079,
0.01017379,
0.020988347,
-0.014816073,
-0.0011769166,
0.017509904,
-0.0045049754,
0.02139373,
0.0030289257,
-0.0033999814,
0.0036288262,
0.004233631,
-0.0029619068,
0.02051758,
0.002089027,
0.013926847,
-0.010435327,
0.023002181,
-0.015090686,
-0.007447267,
0.02126296,
0.0041584386,
-0.007839573,
-0.010003791,
-0.0031270022,
0.0020383543,
0.007800342,
-0.042264383,
-0.0071530375,
-0.009572255,
-0.016725292,
-0.018268362,
-0.040852085,
-0.0053680474,
0.0075976504,
-0.019092202,
0.007538805,
-0.02189065,
-0.011847627,
0.019432202,
-0.014580689,
-0.04430437,
0.037190564,
-0.022204494,
-0.010677249,
-0.014096846,
-0.015156071,
-0.015836067,
0.03622288,
-0.014737612,
0.030495217,
-0.019497585,
0.004668436,
0.019157587,
-0.015051456,
-0.011514167,
-0.017849902,
0.007721881,
-0.03941363,
0.025839858,
0.010141098,
0.023250641,
-0.03575211,
0.0014237422,
-0.017509904,
0.008624183,
0.00934341,
-0.027670618,
-0.0075191897,
0.016123757,
-0.011285323,
-0.003932863,
0.008048802,
0.013887616,
0.035202883,
0.021668343,
0.002147873,
-0.006692079,
0.032875203,
0.019876814,
0.03172444,
0.020465272,
0.019680662,
-0.0011246093,
0.009807639,
0.017575288,
-0.014802996,
-0.027722925,
-0.0045213215,
0.011991473,
0.010141098,
0.0070418846,
0.020661425,
0.022269879,
0.0050313184,
-0.018882973,
0.011736474,
-0.00062523695,
-0.01013456,
0.019392971,
-0.011945704,
0.030756755,
0.030625986,
0.032744437,
0.0042793998,
0.010069176,
-0.011102247,
-0.03483673,
-0.008225339,
0.016502986,
0.0023146027,
-0.007081115,
0.0014891265,
-0.00618862,
0.008421492,
-0.0064730416,
0.0013501849,
0.0014188384,
-0.01025879,
0.0065972717,
-0.0006718232,
0.004419976,
-0.63605803,
0.01889605,
0.028899841,
-0.029762914,
0.018869897,
0.0012365797,
0.028350614,
-0.0018274899,
-0.013900693,
0.016332988,
-0.020138351,
0.021812188,
-0.004302284,
0.0031531558,
-0.014489152,
-0.033659816,
-0.0002707317,
-0.029370608,
0.020909885,
0.01067071,
-0.018046055,
0.009846869,
0.016777601,
0.038105946,
0.006512272,
-0.009140719,
-0.007924572,
-0.027696772,
0.019759122,
0.018948358,
-0.022806028,
0.026546009,
-0.012704161,
-0.011566475,
0.044539757,
-0.025055246,
0.0061657354,
0.024466788,
0.024689095,
0.04739051,
-0.006571118,
-0.01511684,
0.0071857297,
0.010016868,
-0.017536057,
0.016869139,
0.0005717036,
-0.0055053546,
0.00079523603,
-0.0150383795,
0.0012455701,
0.008251493,
0.001021629,
0.00460959,
0.0021331613,
0.002541813,
0.008441107,
-0.02712139,
-0.008088033,
-0.004946319,
-0.0052765096,
0.00959187,
0.009794561,
-0.004129016,
-0.0010584077,
0.028429074,
0.0029717144,
-0.01191955,
-0.0068849623,
-0.02034758,
0.012854544,
0.018595282,
-0.011357245,
0.004854781,
0.013129159,
0.032744437,
0.022413723,
-0.0029766182,
-0.009173411,
0.017509904,
0.006571118,
-0.0078853415,
-0.0064893872,
0.0085195685,
0.018216053,
-0.027696772,
0.0025467167,
0.019066049,
0.0028458498,
0.000760092,
0.0068588085,
0.018333746,
-0.015195301,
-0.017601442,
-0.019706815,
0.034025967,
-0.015927605,
-0.009448025,
0.011867243,
-0.02944907,
-0.026755238,
-0.0052503557,
0.022400646,
0.0034065198,
0.018137593,
-0.0052470868,
-0.014214537,
0.02139373,
0.019929122,
0.0019141241,
0.025159862,
0.002205084,
0.009147258,
0.007048423,
0.012063395,
-0.028167538,
0.022309108,
-0.0028523882,
0.007983418,
-0.034915194,
0.01486838,
0.017274521,
0.007898418,
-0.025094477,
0.014489152,
0.017052215,
-0.016385294,
-0.016032219,
-0.00017888725,
-0.026192933,
-0.015103763,
-0.018556053,
0.008996874,
-0.022583723,
0.013822231,
0.012089549,
0.017300675,
-0.0025221978,
0.009356488,
-0.022622952,
-0.023237566,
-0.011063016,
-0.0026644084,
-0.0075845737,
-0.020661425,
-0.0252514,
-0.01532607,
-0.01731375,
-0.0075649587,
-0.024898324,
0.027330618,
-0.01805913,
-0.010932248,
-0.021027576,
-0.0023521986,
0.0006787703,
-0.027069082,
-0.036144417,
-0.0050117034,
-0.0058584292,
0.019118357,
0.0068849623,
-0.03679826,
-0.010369943,
-0.019366818,
-0.02334218,
-0.014423767,
0.004560552,
0.005129395,
-0.03967517,
0.009245334,
-0.024453713,
0.012671469,
0.015064533,
-0.00087533175,
-0.0001789894,
-0.029396761,
0.00917995,
-0.02492448,
-0.017457597,
0.025238324,
-0.013822231,
-0.022282954,
-0.019536816,
0.05008434,
-0.004351322,
0.041584387,
0.025447553,
-0.014018385,
0.019824507,
-0.004596513,
-0.001956624,
-0.012965698,
0.017915286,
0.016176065,
-0.0181899,
0.025826782,
0.036667492,
-0.008957643,
0.021066807,
0.028245999,
-0.0011417726,
-0.009212642,
-0.008081494,
0.03057368,
-0.005034588,
0.011455322,
-0.00872226,
-0.01029802,
0.01952374,
0.0208445,
0.011108785,
-0.0077938032,
-0.02467602,
0.0131030055,
0.002898157,
-0.0031907517,
0.029161379,
-0.014920687,
-0.008447646,
-0.0011728301,
-0.0054301624,
0.028219845,
0.022649106,
-0.0075780354,
0.027853694,
-0.011971857,
0.014646074,
-0.0034326734,
-0.0048580505,
-0.029056763,
0.009369564,
0.0011850897,
0.0008356925,
0.0196022,
0.0030093105,
0.006420734,
-0.03538596,
0.008277647,
0.0009897542,
0.010304559,
0.0023015258,
0.022021418,
-0.008159955,
0.027461387,
-0.027696772,
0.015103763,
0.012056857,
0.00010364426,
-0.0041747848,
0.008199186,
-0.0037138257,
0.00294883,
0.011435706,
0.00921918,
-0.0062801577,
0.0024895056,
-0.010808018,
0.023486026,
0.016790677,
0.011298399,
-0.0037301718,
-0.0025597936,
0.01100417,
0.02840292,
0.009598409,
-0.015051456,
-0.0029324838,
0.010618404,
0.014397614,
-0.023708332,
-0.0096114855,
0.001981143,
0.005577277,
0.0065188105,
0.0008467261,
0.0051195873,
0.0114226295,
0.00073148636,
0.0084738,
-0.010938786,
-0.038681325,
0.015182224,
0.01557453,
-0.01258647,
-0.010651096,
-0.0063618883,
0.005636123,
-0.016659908,
0.0155353,
0.016123757,
0.0061984276,
-0.016293757,
-0.011533783,
0.0028654651,
0.010690326,
0.026376009,
-0.0146199195,
-0.00015079245,
-0.00606439,
0.021681419,
-0.013547618,
-0.040433623,
0.009931869,
0.023276795,
0.023826024,
-0.034810577,
-0.026519854,
0.0052928557,
0.0049659344,
-0.02172065,
-0.032744437,
-0.0003111882,
0.017496828,
-0.016359141,
0.00051163184,
-0.00436113,
0.01528684,
0.018882973,
0.020491427,
-0.027278312,
-0.024322944,
-0.031305984,
-0.004792666,
0.046318207,
0.014972995,
-0.015273762,
0.029187532,
0.002628447,
-0.002151142,
0.007316498,
0.004482091,
0.019968351,
-0.011743013,
-0.0018405669,
0.0031253675,
0.03512442,
0.004393822,
0.023433717,
0.035490576,
-0.013259927,
-0.019209895,
0.0009129277,
0.016306834,
0.0023816216,
-0.02753985,
0.014044538,
0.027592156,
0.02973676,
0.0055838157,
0.03350289,
0.00685227,
0.013050698,
-0.018660666,
-0.024519097,
0.02412679,
-0.00160927,
0.021733727,
0.0059172753,
-0.000019538655,
-0.007963803,
-0.027461387,
-0.01108917,
0.0012447528,
0.026140627,
0.014724535,
0.013639156,
-0.007819957,
0.0052601635,
-0.0015970104,
0.030704446,
0.026886007,
-0.009735716,
-0.011049939,
0.0034947884,
0.00042540632,
0.008414954,
-0.016476832,
0.0075518815,
0.0005108145,
0.0013550887,
0.008866105,
0.0075191897,
-0.052098177,
-0.014489152,
-0.016254526,
0.016542217,
-0.024780633,
-0.032221362,
-0.0032953664,
-0.019746045,
-0.0041878615,
-0.052045867,
-0.0059630442,
-0.0051882407,
-0.05905506,
0.001897778,
-0.025617551,
0.009173411,
0.009539563,
0.015757605,
0.0034915193,
0.03114906,
0.027304465,
-0.01420146,
-0.003310078,
-0.0056132386,
-0.0254214,
0.009206103,
0.0063684266,
-0.019392971,
-0.020125274,
0.006051313,
0.0047567044,
0.029213686,
-0.017784517,
-0.009284564,
-0.0060055437,
0.0105791725,
-0.001131965,
0.0024322944,
0.010141098,
0.018098362,
-0.028795227,
0.024022175,
-0.012351086,
-0.006463234,
-0.02122373,
-0.0063618883,
0.008996874,
-0.014999148,
-0.0021462382,
-0.0075518815,
-0.010906094,
0.04754743,
-0.045115136,
0.012390316,
0.011533783,
0.0058715064,
0.0009415333,
0.01349531,
-0.0023914292,
0.016437601,
-0.011821474,
0.006806501,
0.0032822897,
0.011108785,
0.023263719,
-0.028638305,
0.01337108,
-0.015509145,
-0.023969868,
-0.04846281,
-0.019000664,
0.023316026,
0.01927528,
0.0053059324,
-0.0127107,
-0.01299839,
0.0028213307,
-0.012691084,
0.013116082,
-0.024427557,
-0.0088137975,
-0.010847248,
0.006329196,
-0.008225339,
-0.0062540043,
0.012802238,
-0.03261367,
-0.01133763,
0.012122241,
-0.0045049754,
0.019118357,
-0.010056099,
-0.008617645,
0.0041715153,
-0.020936038,
-0.023956792,
-0.013220697,
0.00046749745,
-0.01486838,
0.02433602,
0.010474558,
0.02213911,
0.000018082834,
0.04380745,
0.02387833,
0.010154175,
0.0061036204,
-0.0046749744,
0.003857671,
-0.015273762,
0.0042042076,
-0.011834551,
-0.005835545,
-0.023420641,
-0.003293732,
0.003056714,
0.02338141,
-0.029239839,
-0.011095708,
-0.017078368,
-0.040276702,
-0.011945704,
0.0012341278,
0.0070091924,
0.022531414,
-0.01952374,
-0.0025777742,
0.014188384,
0.0009881196,
-0.0004213198,
-0.018046055,
0.01004956,
0.0030256566,
0.028690612,
-0.025944473,
0.006234389,
-0.017601442,
0.00033611595,
-0.03198598,
-0.008676491,
-0.011494553,
-0.009997252,
0.031750593,
0.0004299015,
0.002641524,
-0.00042826688,
-0.02034758,
-0.009742254,
0.017889133,
0.024231406,
-0.007669573,
0.0069372696,
-0.014057615,
-0.005404009,
-0.026101395,
0.01798067,
0.020256042,
-0.014149153,
0.017849902,
-0.005086895,
-0.0034195967,
0.011370323,
0.0015071072,
0.034862887,
-0.0124295475,
0.034444425,
0.002595755,
-0.011978396,
-0.029161379,
0.008277647,
0.0066168867,
0.014423767,
0.034810577,
-0.008924951,
-0.007617266,
-0.014972995,
-0.0061918893,
0.0030370988,
-0.025656782,
-0.04328438,
0.02574832,
-0.014476075,
-0.00028952965,
-0.028769072,
0.009689947,
-0.0032675783,
0.008506492,
-0.0039851703,
0.014122999,
0.020360658,
-0.0052307406,
0.011474937,
0.020321427,
0.014031461,
0.022819106,
0.002919407,
0.0057047764,
-0.005655738,
-0.01769298,
-0.0062082354,
-0.0018912397,
0.008343031,
0.014567613,
0.009238795,
-0.014175307,
0.017954517,
-0.0005578094,
-0.011828012,
-0.008911874,
-0.022583723,
0.040512085,
-0.019589122,
-0.021119114,
-0.016385294,
0.02782754,
-0.003994978,
-0.0016983561,
-0.019889891,
-0.016607601,
-0.005914006,
-0.025735244,
0.03834133,
0.0080161095,
0.00031936122,
-0.004469014,
-0.024152944,
0.012579931,
-0.030050604,
-0.03177675,
0.016267603,
-0.0254214,
0.011586091,
0.0009840331,
0.00039782232,
0.018595282,
0.014279922,
-0.004593244,
-0.008382262,
0.023682177,
-0.0127237765,
0.017496828,
0.009075335,
-0.0034980578,
-0.037896715,
0.022047572,
-0.015391454,
-0.012181087,
0.005381124,
-0.009794561,
-0.005668815,
0.0049070884,
-0.0013485503,
0.020687578,
0.0040440164,
0.013305697,
-0.003318251,
0.0037367102,
0.014920687,
-0.014384536,
0.0055511235,
0.03384289,
0.009336872,
-0.017719133,
0.02425756,
0.011344168,
0.010513788,
-0.027801385,
0.007937648,
0.012612623,
-0.022269879,
-0.0038772863,
-0.019458355,
0.013547618,
0.003318251,
-0.0008418223,
-0.016790677,
-0.015679145,
-0.016045297,
0.02362987,
-0.0140706925,
-0.0023472947,
-0.016084528,
0.012632239,
-0.0035078654,
0.016306834,
-0.0088137975,
-0.0027526773,
-0.00909495,
-0.003824979,
-0.060990434,
-0.0029063302,
-0.016686061,
0.032692127,
0.016869139,
-0.0019255664,
-0.024218328,
0.011729935,
-0.04888127,
-0.019654507,
-0.004639013,
0.0072314986,
-0.0035372882,
0.01167109,
-0.00321854,
0.02172065,
-0.009500332,
0.024479866,
-0.0016010969,
-0.007715342,
0.0049397806,
0.0016182604,
0.009683409,
0.01486838,
-0.03161983,
-0.011762627,
0.018752204,
-0.021236807,
-0.027932154,
0.016293757,
-0.012056857,
0.019157587,
-0.019680662,
0.005835545,
0.050947413,
0.019052973,
0.0051718946,
-0.02450602,
-0.04244746,
-0.0051359334,
0.0033967122,
-0.01511684,
0.005132664,
-0.017679904,
-0.016829908,
0.024440635,
-0.05905506,
-0.021380652,
0.00963764,
-0.0013787905,
0.0043447837,
0.01885682,
0.009199565,
0.02345987,
0.01229224,
-0.015927605,
-0.027696772,
-0.0016918177,
-0.013351466,
0.042107463,
-0.022989105,
-0.02296295,
-0.0007976879,
-0.022858337,
0.009794561,
-0.026271394,
0.0121353185,
-0.011409553,
-0.02882138,
0.004998626,
0.026859853,
0.036667492,
-0.0078853415,
-0.0054922774,
0.014528382,
-0.0011597533,
0.005577277,
-0.010114945,
-0.02134142,
-0.027801385,
0.014253768,
-0.006878424,
-0.013900693,
0.0033035395,
-0.012148395,
0.0120503185,
-0.03674595,
0.009840331,
0.18516822,
-0.011357245,
0.009173411,
0.020687578,
-0.0023718139,
-0.011115324,
0.021210654,
0.00992533,
-0.010513788,
0.0004274496,
0.008460723,
0.012946083,
-0.008539184,
0.013155312,
0.0324829,
-0.024270637,
-0.013547618,
-0.014802996,
0.0045115137,
0.032665975,
0.016999906,
-0.011435706,
-0.005341894,
-0.019066049,
0.044984367,
0.012436085,
-0.03185521,
-0.012553778,
0.0065547717,
-0.014698381,
-0.004688051,
0.0049528573,
0.019916045,
0.012612623,
0.017130675,
0.008761491,
0.030102912,
0.016162988,
0.015522223,
0.0034359426,
-0.0075845737,
0.015718374,
0.047625892,
-0.007976879,
0.0053124707,
0.0122203175,
0.008212263,
0.0053059324,
-0.009670331,
-0.01108917,
-0.011710321,
0.016581448,
-0.00009863828,
0.025081402,
-0.01557453,
-0.006747655,
0.027095236,
-0.03057368,
-0.0033705584,
0.02139373,
-0.0009104758,
0.028481383,
-0.0128087755,
0.0059990054,
-0.025473706,
0.039178245,
-0.019092202,
-0.0036745952,
-0.006084005,
0.004197669,
-0.00481882,
-0.022505261,
-0.008964182,
0.005717853,
-0.0059172753,
-0.020713732,
0.011023786,
0.004099593,
0.041061312,
0.023786793,
-0.003019118,
0.011272246,
-0.019484509,
-0.023289872,
-0.012161472,
-0.034444425,
0.03263982,
-0.009363025,
-0.026964467,
-0.014188384,
0.00021270316,
-0.0042369,
-0.016777601,
-0.015365301,
0.02753985,
0.011697244,
-0.004701128,
0.030861368,
-0.039465938,
-0.028455228,
-0.0015218186,
0.03933517,
0.032665975,
0.019889891,
0.006515541,
0.0048972806,
-0.017418366,
0.014515305,
0.00502478,
-0.0122203175,
0.005992467,
-0.016424526,
0.0036909413,
-0.0024927747,
0.0024911403,
0.0112918615,
0.02782754,
-0.013730694,
0.033685967,
0.020072967,
-0.0134822335,
-0.031593673,
0.039779782,
0.028925994,
0.017392213,
-0.015496069,
-0.033921354,
0.029579837,
-0.0060055437,
-0.008624183,
-0.0136914635,
-0.026572162,
-0.0064043878,
0.008866105,
0.002010566,
0.0017457596,
-0.021498343,
-0.040590547,
0.002787004,
-0.0048449733,
-0.009807639,
-0.004740359,
0.0054432396,
0.015260685,
0.007833034,
-0.007394959,
0.00377921,
0.00131831,
-0.011082632,
-0.008911874,
-0.012423009,
0.008382262,
-0.016999906,
0.010206482,
0.013129159,
0.0026660431,
-0.0098207155,
-0.013253389,
-0.011416092,
-0.00037473353,
-0.0136522325,
0.0112134,
0.012991852,
-0.021498343,
-0.0030779638,
0.0007036981,
-0.16309449,
0.01731375,
0.015666068,
-0.011592628,
0.01748375,
-0.0017392213,
0.005404009,
-0.007068038,
-0.018046055,
-0.021171423,
0.03433981,
0.016215296,
-0.030102912,
-0.026572162,
0.014018385,
0.0036811337,
-0.007963803,
0.024244482,
0.0037922869,
0.019994505,
0.021576805,
-0.045821287,
0.014515305,
0.018372975,
0.007924572,
0.03687672,
0.008951105,
0.0071072686,
0.015234532,
-0.047442816,
-0.003172771,
0.004688051,
0.016097603,
-0.019249124,
0.012521085,
-0.0035176731,
-0.014933764,
-0.017470673,
-0.007852649,
0.006623425,
0.024362175,
0.012547239,
-0.002350564,
0.002245949,
0.0004017045,
0.00024580394,
-0.012972237,
0.001131965,
-0.0009464371,
-0.017418366,
0.010500711,
0.010638018,
0.013992231,
-0.01486838,
-0.000014277265,
-0.008918413,
0.0060415054,
0.030469064,
0.014907611,
-0.019406047,
0.0060251593,
-0.025460629,
0.01599299,
-0.0015594146,
-0.0037890177,
-0.020739887,
-0.021106038,
0.014580689,
-0.021799112,
-0.005469393,
0.012691084,
0.0039361324,
0.0034359426,
-0.007512651,
0.013390696,
0.008735336,
-0.026650622,
0.019497585,
-0.023656024,
-0.021302192,
-0.026519854,
0.026650622,
-0.0238391,
-0.014606843,
0.016581448,
-0.011814935,
0.0052503557,
0.00012566037,
0.009572255,
0.004037478,
0.029972143,
-0.03263982,
-0.004289207,
-0.03622288,
0.011278784,
0.008539184,
0.022413723,
-0.012266086,
0.016228372,
-0.0077807265,
0.0047370894,
-0.02172065,
-0.01736606,
0.012802238,
0.010317636,
-0.010938786,
0.020635271,
-0.008656875,
0.03538596,
-0.007649958,
-0.008787644,
-0.0058159297,
-0.005822468,
0.013809155,
-0.023603717,
0.042342845,
0.00008438656,
-0.016921446,
0.018948358,
-0.031541366,
0.050058186,
-0.011782243,
0.010082252,
-0.006969962,
0.009206103,
-0.03413058,
-0.13233773,
0.012403393,
0.015273762,
0.012115703,
-0.0061297743,
-0.008127263,
-0.026389087,
0.033241358,
-0.018255284,
0.05311817,
-0.013979154,
0.0005034588,
-0.006989577,
-0.014005308,
0.045873594,
0.0136522325,
0.0028556574,
-0.028298305,
0.006943808,
0.039282862,
0.03057368,
-0.019327587,
-0.01748375,
-0.0020972001,
-0.025225246,
0.022282954,
-0.03143675,
0.026702931,
0.009873022,
-0.01025879,
0.003086137,
-0.009336872,
-0.019118357,
-0.024270637,
-0.013364542,
-0.024401404,
-0.022099879,
-0.021864496,
0.028664459,
-0.0043349764,
-0.025277553,
0.005668815,
0.013848386,
-0.0020906616,
-0.006865347,
-0.019262202,
-0.011370323,
-0.0035601729,
0.018216053,
-0.02158988,
-0.011958781,
-0.022243723,
-0.025696013,
-0.012632239,
0.015901452,
0.0096964855,
-0.002234507,
0.007198807,
-0.0022737375,
0.051392026,
0.007296883,
0.017575288,
-0.027435234,
0.019301433,
0.024662942,
-0.016672986,
-0.045167446,
-0.017130675,
0.023682177,
-0.023185257,
-0.0045540133,
0.035307497,
-0.012789161,
0.0061559277,
-0.020177582,
0.030678293,
-0.027199851,
0.008414954,
0.002724889,
-0.023682177,
-0.005851891,
-0.012828391,
0.010428789,
-0.021132192,
0.011187246,
-0.005560931,
0.0048515117,
-0.008127263,
0.012553778,
-0.030181373,
-0.008441107,
0.009284564,
0.022086801,
-0.028089076,
0.023289872,
0.0046324744,
-0.021550652,
-0.017182983,
0.020674502,
0.009310718,
-0.036432106,
-0.006374965,
-0.028089076,
0.026585238,
0.0013076852,
-0.020936038,
0.015979912,
-0.004639013,
-0.0029373877,
-0.018804513,
-0.020661425,
0.027356774,
-0.016084528,
0.01811144,
-0.020112198,
-0.01324685,
-0.00073230366,
-0.018778358,
-0.01631991,
0.00041396407,
0.030625986,
0.014266845,
-0.016842984,
-0.0117560895,
0.05481816,
0.018464515,
-0.016398372,
-0.013783001,
-0.023525255,
-0.004498437,
-0.00019063597,
-0.022374492,
0.0121353185,
-0.025186015,
-0.004518052,
0.010239175,
0.014789918,
-0.023224488,
0.023812946,
0.0032839242,
0.0015340782,
0.03891671,
0.0017310482,
0.0066168867,
0.0222568,
-0.020007582,
-0.014083769,
0.017849902,
-0.024022175,
0.0032021939,
0.012697622,
0.0041584386,
0.03687672,
0.0020465273,
0.0154568385,
-0.028062923,
-0.0053680474,
-0.009454563,
0.020216811,
0.03460135,
0.008434569,
-0.022282954,
0.018660666,
0.01391377,
0.010088791,
-0.0065384256,
-0.013194543,
-0.011553398,
-0.01756221,
0.009356488,
0.0053222785,
-0.0054628546,
-0.011573014,
-0.017876055,
-0.0003585918,
0.009160334,
-0.0017228752,
0.011259169,
0.008794183,
0.012468778,
-0.0027510426,
0.020360658,
-0.020739887,
0.015482992,
-0.01087994,
-0.0003310078,
0.03164598,
0.0054792007,
-0.0016950868,
0.01847759,
-0.0063259266,
0.01312262,
-0.020386811,
0.017967593,
0.0015863855,
0.01624145,
0.0077480343,
0.0264937,
-0.0063684266,
0.0037857485,
0.016699139,
0.024728326,
-0.020007582,
0.008336493,
0.0076891887,
-0.032587513,
0.003658249,
-0.0238391,
-0.00006242153,
-0.037765946,
-0.01731375,
0.005681892,
0.0104941735,
0.0024453711,
0.002463352,
-0.006701886,
-0.013429927,
0.016189141,
-0.019340662,
-0.0057538147,
-0.024976786,
0.0154176075,
-0.023904484,
0.020739887,
-0.0117560895,
-0.009186488,
0.009853408,
0.016699139,
0.025356015,
0.00022353242,
0.009258411,
-0.016555294,
0.020609118,
-0.008192647,
-0.0155353,
-0.007251114,
0.0021527766,
-0.03015522,
0.008787644,
0.012919929,
-0.008996874,
0.068731934,
0.0018830666,
-0.0011286957,
0.031933673,
-0.030887524,
0.025460629,
0.015090686,
0.013155312,
-0.028298305,
-0.018464515,
-0.0016999907,
-0.0050280495,
0.01624145,
-0.009905715,
-0.013233773,
0.0110434005,
-0.020321427,
0.007244576,
-0.01723529,
-0.011442245,
0.040015165,
-0.023263719,
0.032090593,
0.01233801,
-0.008506492,
-0.024715248,
0.014057615,
0.00038617576,
-0.0044493987,
0.0023293141,
-0.0035863265,
0.013874539,
-0.045036677,
-0.01200455,
0.004606321,
0.016411448,
-0.012494931,
-0.018739128,
0.0048417044,
-0.017287597,
-0.00068040495,
-0.017222213,
-0.03611826,
0.0035830573,
-0.0027297926,
-0.012213779,
-0.03447058,
-0.011076093,
-0.037399795
] |
BACKGROUND Patients with signs and symptoms of heart failure and a normal left ventricular ejection fraction are said to have diastolic heart failure. It has traditionally been thought that the pathophysiological cause of heart failure in these patients is an abnormality in the diastolic properties of the left ventricle; however, this hypothesis remains largely unproven. METHODS We prospectively identified 47 patients who met the diagnostic criteria for definite diastolic heart failure; all the patients had signs and symptoms of heart failure, a normal ejection fraction, and an increased left ventricular end-diastolic pressure. Ten patients who had no evidence | [
-0.02633448,
0.02522672,
0.019650154,
-0.027719181,
-0.04149065,
0.034743387,
-0.027190477,
0.007722851,
-0.02121109,
-0.0001817419,
-0.018403925,
0.038419135,
-0.012638536,
0.0073766755,
-0.011763657,
0.009378197,
0.034491625,
-0.0048338627,
0.017056989,
-0.016540874,
-0.008421495,
0.031697046,
-0.011788834,
-0.0049125385,
-0.019864153,
0.012418243,
0.015118409,
-0.014702998,
-0.007622145,
0.014841469,
0.0002879547,
-0.003486927,
-0.041843124,
-0.0121727735,
-0.0004350791,
-0.008666964,
-0.021148149,
-0.0013634576,
0.020820856,
-0.017283576,
0.025138604,
-0.0040817186,
-0.028927647,
-0.016717108,
-0.027719181,
0.012550419,
0.022683907,
-0.012021716,
-0.0013264798,
0.01216648,
0.0230112,
0.00066560024,
-0.013330886,
0.010643309,
0.00070965884,
-0.020204036,
-0.0015215967,
0.008415201,
0.0067472663,
-0.044511817,
-0.012330126,
-0.010309722,
-0.0068983245,
0.0010400987,
-0.019234745,
0.00901314,
0.01119719,
0.01642758,
0.026082717,
0.018517219,
0.027291182,
0.0062059746,
-0.020908972,
0.043630645,
0.019159216,
-0.008585141,
-0.00066914066,
-0.023300728,
-0.0062909448,
0.008402613,
0.010693662,
-0.027039418,
-0.02536519,
0.030614464,
0.010064253,
0.0023303875,
-0.0048307157,
0.017270988,
-0.015193937,
-0.0069423835,
-0.0021714617,
0.009082374,
-0.004106895,
0.00021478589,
-0.0032540455,
-0.0024845928,
0.013318298,
0.0022642994,
0.020745326,
-0.024156725,
-0.009365609,
-0.009932077,
-0.03298104,
0.00012116127,
-0.0011628334,
-0.0034711917,
-0.0044153053,
-0.0064640325,
0.020682385,
-0.02244473,
-0.023653198,
0.011908421,
0.00025864784,
-0.0021038002,
0.033031393,
-0.01739687,
0.02244473,
-0.0011565394,
0.01753534,
-0.02106003,
0.01538276,
-0.013834414,
0.026107892,
-0.030413052,
-0.019171804,
-0.02882694,
-0.025742836,
-0.024962367,
0.004733157,
0.0074081463,
0.0016270227,
0.02065721,
-0.0006707142,
-0.014665234,
-0.013935119,
-0.009478902,
0.0029755319,
0.0023791667,
-0.023363668,
-0.039803836,
-0.0013013035,
0.00639165,
-0.014010648,
-0.04519158,
0.00025373057,
-0.00226902,
0.002121109,
0.017963339,
0.0134064155,
-0.004723716,
-0.020694975,
0.0034523094,
0.0018410218,
-0.01676746,
-0.03298104,
0.024043432,
0.0125818895,
-0.0017135665,
0.000071005226,
-0.016087698,
-0.00959849,
-0.006048622,
0.020254388,
-0.0227972,
0.009913195,
0.0040880125,
0.0029991348,
-0.015634524,
0.007886497,
-0.028298236,
-0.019776037,
0.031067638,
-0.013393828,
0.026838008,
0.033560097,
-0.0020204035,
0.011732187,
-0.004110042,
-0.023766492,
-0.022130027,
-0.031822927,
0.030161288,
0.00929008,
0.0040093367,
-0.016100287,
0.026460363,
0.030941755,
-0.04385723,
-0.006797619,
-0.023262963,
-0.0188571,
0.018051455,
0.000035674715,
0.002840209,
-0.6324304,
-0.008056438,
-0.0074773813,
-0.021047443,
-0.0058125937,
0.02030474,
0.009120139,
0.012040597,
-0.010385252,
0.008194908,
-0.029129056,
0.013620415,
0.0068290895,
-0.00019147807,
0.0038708665,
-0.00727597,
-0.009648843,
-0.011650364,
-0.0054695657,
0.004918833,
-0.009264903,
0.022822376,
-0.016893342,
0.025616953,
0.010366369,
0.024282606,
0.0059227403,
0.004777216,
0.010360075,
0.03209987,
0.0018252867,
0.019045921,
-0.0082893185,
0.010806955,
0.051334612,
-0.005082479,
-0.025000133,
0.0069990302,
-0.008144555,
0.016163228,
-0.0021714617,
0.01656605,
0.042220768,
-0.011996539,
-0.01510582,
0.00752144,
0.017296165,
-0.005535654,
0.0011195616,
-0.013683355,
0.011694423,
-0.018806746,
-0.028021296,
0.032603394,
0.014577117,
-0.014640057,
0.005545095,
-0.017056989,
-0.009718078,
0.015848523,
0.024484018,
0.0069675595,
-0.010775485,
0.0022894759,
0.03290551,
0.0052492726,
0.014300177,
-0.0013862738,
0.002473578,
-0.020141093,
-0.0026246363,
0.01510582,
0.00921455,
-0.00016590832,
0.05473342,
-0.013507121,
0.027165301,
0.028147178,
-0.028650707,
-0.009623666,
0.00004627141,
0.017447222,
-0.01656605,
-0.0041478067,
0.033308335,
0.018290631,
-0.00807532,
0.014073589,
-0.02030474,
-0.0054727127,
-0.003896043,
0.010888779,
0.014803704,
-0.028499648,
-0.014602293,
0.048816975,
-0.013746297,
0.006303533,
0.0129028885,
0.0027017388,
-0.022331437,
-0.008050144,
-0.0033988096,
0.0018630512,
0.008301907,
0.014161707,
-0.02259579,
-0.016402403,
0.03298104,
-0.048414156,
0.015785582,
-0.034214683,
-0.010882485,
0.0013217593,
-0.011700717,
-0.030110935,
0.002259579,
-0.0067724427,
0.030740345,
-0.023829432,
0.003770161,
-0.021790147,
0.024572134,
-0.017610868,
-0.013381239,
0.0015648686,
-0.0007175265,
-0.009976136,
-0.016742283,
-0.01641499,
0.009655137,
-0.016691932,
0.034667857,
0.0059132995,
-0.004056542,
-0.00226902,
0.01552123,
0.023338493,
0.008943904,
-0.015282055,
-0.021953793,
-0.014312765,
0.0049660383,
0.0019023892,
-0.0067724427,
0.000042067153,
-0.0050226855,
-0.0216265,
-0.0011596864,
0.01524429,
-0.03436574,
-0.027845062,
-0.0013241195,
0.039753485,
-0.0048212744,
-0.02133697,
0.028776588,
-0.034139153,
-0.0184291,
-0.023942726,
0.02724083,
0.010945425,
-0.029280115,
0.007452205,
-0.019574625,
-0.020367682,
-0.007326323,
-0.03507068,
-0.014753351,
-0.030110935,
0.0026183422,
0.013557474,
0.0040817186,
0.0064010913,
-0.00078558136,
-0.0028134591,
0.0053688604,
-0.009680313,
0.0018819334,
-0.0074207345,
0.03008576,
-0.027945768,
-0.00010021374,
0.018278042,
0.03230128,
0.0060675046,
0.026989065,
-0.0029833994,
-0.01947392,
0.013557474,
-0.0022485643,
0.02252026,
-0.0044278936,
-0.0010762897,
-0.009277491,
-0.007722851,
0.008087908,
0.0075717927,
-0.0042705415,
0.022746848,
0.020820856,
0.00304162,
0.024861664,
-0.017245812,
0.006036034,
-0.008899846,
0.0020959326,
-0.0031140018,
0.02252026,
0.013784061,
-0.0081067905,
0.007471087,
-0.005293331,
-0.020090742,
-0.011713305,
0.035397973,
0.022218144,
0.010158665,
0.0009700769,
0.0003082138,
0.007999791,
-0.011285307,
0.0145015875,
0.030136112,
0.00031332776,
-0.009686607,
0.006797619,
-0.0002248171,
0.0041352184,
-0.021425089,
-0.01153707,
0.008987963,
0.014702998,
0.01892004,
-0.010202723,
0.05226614,
0.008748787,
-0.0040219245,
0.01524429,
-0.008056438,
-0.0129028885,
0.01684299,
0.0010778633,
0.0015160894,
-0.0061461804,
0.010095723,
0.010108312,
0.0255666,
0.0058031525,
0.023653198,
0.012493772,
0.011650364,
-0.0058692405,
-0.01690593,
-0.011480424,
-0.00890614,
0.00036446727,
0.011134248,
0.023262963,
0.015193937,
0.045367815,
0.0067913253,
0.0064766207,
-0.010284546,
0.03716032,
0.0041037477,
0.0050950674,
-0.0038582783,
0.0025019015,
-0.019511685,
-0.0150051145,
0.0022800348,
-0.0014885527,
-0.044260055,
0.031294223,
-0.00047323704,
0.0034302801,
0.010164958,
0.018454278,
0.0012934359,
-0.016729696,
-0.030866226,
0.001748184,
0.021639088,
0.0059132995,
-0.003021164,
0.009120139,
0.01579817,
-0.01233642,
0.04546852,
-0.002800871,
-0.014715587,
0.01815216,
-0.017434634,
0.0069549717,
0.00915161,
0.010794368,
0.022507673,
0.019247333,
0.014740763,
0.00052595005,
-0.008308201,
-0.025679894,
-0.01641499,
0.026435185,
0.02031733,
-0.0077165565,
-0.0003162781,
0.02244473,
0.021223677,
-0.024974957,
-0.020153683,
0.0026875772,
0.0010715692,
0.019159216,
0.01175107,
-0.01601217,
0.012632242,
0.036757495,
-0.0103915455,
0.0016105007,
-0.0044845403,
-0.007980908,
-0.03265375,
0.03215022,
-0.010347487,
0.011738481,
0.0138595905,
-0.00879914,
0.011360836,
0.014048413,
-0.024660252,
0.02238179,
0.039602425,
0.007836144,
-0.013293122,
0.013570062,
0.016893342,
-0.00016718681,
0.024559546,
0.013104299,
-0.0038614254,
-0.0028559442,
0.008981669,
-0.027568122,
0.0035404267,
0.03340904,
0.028675882,
-0.018882275,
-0.0075969687,
-0.005563977,
0.002190344,
0.025063073,
0.017787103,
-0.033862215,
0.012884006,
-0.010246782,
0.025453307,
0.0033075453,
0.0029251792,
-0.006095828,
0.0053783013,
0.022834966,
-0.0008032835,
0.014086178,
0.013872178,
0.005069891,
0.017333928,
0.0071563823,
-0.0010298708,
0.0008512759,
0.021639088,
0.026183423,
-0.0017985367,
0.0303627,
-0.018554982,
-0.017975926,
-0.021034855,
0.016037347,
-0.0061084162,
-0.00071870664,
0.0038016315,
-0.024760958,
-0.0092019625,
-0.008131967,
-0.032628573,
0.014539352,
0.016880754,
-0.000755291,
-0.01095172,
-0.039174426,
-0.017698986,
-0.010838426,
0.0032823689,
-0.018189926,
0.008497024,
-0.014186883,
0.028147178,
0.0115307765,
0.002398049,
0.007748027,
-0.005142273,
0.004160395,
-0.010316016,
-0.010611839,
0.016175816,
-0.00752144,
-0.014614881,
0.0058472115,
0.012884006,
-0.04262359,
-0.007993497,
0.019423567,
0.013544885,
0.01586111,
-0.013695944,
0.027341535,
0.0061745043,
0.009825077,
0.017711574,
0.020896384,
0.008497024,
-0.003826808,
-0.013557474,
0.017208047,
-0.024962367,
-0.0031848105,
-0.007351499,
-0.0255666,
-0.006250033,
-0.021576148,
-0.021639088,
0.013872178,
-0.013557474,
0.009359314,
-0.030538933,
-0.00942855,
0.0004126564,
0.045166403,
0.030413052,
0.0025491072,
0.014753351,
0.04068501,
-0.0038803075,
0.0030636492,
0.001391781,
0.03514621,
-0.018252866,
-0.020367682,
0.030866226,
0.011574835,
-0.03076552,
-0.049647797,
-0.00014142037,
-0.01656605,
0.042850178,
0.0025978864,
-0.027391888,
-0.07467311,
0.025931658,
-0.00011634235,
0.0116251875,
0.014337941,
-0.010618133,
-0.00012775039,
0.0017261547,
-0.01302877,
-0.02708977,
0.040559128,
-0.03111799,
-0.0012013848,
-0.0017198606,
-0.01822769,
-0.01510582,
-0.033308335,
0.016100287,
-0.017157694,
0.0023634315,
-0.020871209,
-0.033660803,
-0.008899846,
-0.025679894,
0.016956283,
0.01670452,
0.012512655,
0.00727597,
0.011555953,
0.025314838,
-0.0061272983,
0.009277491,
-0.012122421,
-0.012714066,
-0.011310483,
0.04755816,
0.0232252,
0.004714275,
0.01195248,
-0.03507068,
0.031772576,
0.00741444,
-0.015584172,
-0.011927304,
-0.023867195,
-0.04060948,
0.0034774859,
-0.0058535053,
-0.00201883,
0.021978969,
-0.040307365,
-0.013922531,
0.007886497,
-0.007861321,
-0.021236265,
-0.027291182,
-0.00035286252,
-0.013217593,
0.018189926,
0.010762897,
-0.012355302,
-0.01316724,
-0.008446671,
-0.011518188,
-0.00071201916,
0.001510582,
-0.0070934417,
0.026208598,
0.016087698,
-0.0011053999,
-0.02127403,
-0.011467835,
-0.039677955,
-0.0010448192,
-0.009529255,
-0.022847554,
0.0033862214,
-0.014841469,
-0.032326456,
-0.02870106,
0.0045474814,
0.008465554,
-0.0033043982,
0.012487479,
-0.020418033,
0.0005133619,
-0.009000551,
-0.013784061,
0.002424799,
-0.0090634925,
0.031294223,
0.0010361648,
-0.025830952,
-0.03383704,
-0.008163437,
-0.01316724,
0.02245732,
0.01933545,
-0.0037229552,
-0.024030842,
0.004106895,
0.016893342,
0.040483598,
-0.022293674,
0.00072185363,
0.037059613,
0.009755842,
-0.008950199,
0.022709083,
0.00026907242,
-0.03172222,
0.0022642994,
0.00057236897,
-0.008943904,
-0.019851565,
-0.027719181,
-0.010687368,
0.02668695,
-0.023086729,
0.03272928,
0.0019936536,
-0.017522752,
-0.00439957,
-0.0095229605,
-0.019322863,
0.011253837,
-0.009485196,
-0.00014161707,
-0.016087698,
-0.02216779,
0.0032634865,
0.031848107,
-0.020883797,
-0.0055419477,
-0.01579817,
0.037890434,
0.016968872,
-0.0062720627,
0.02411896,
-0.020871209,
0.008345966,
-0.00793685,
-0.005409772,
-0.033585273,
-0.010718838,
-0.013456768,
0.041213714,
0.014803704,
-0.0027631063,
0.002833915,
-0.021122972,
-0.019373214,
0.0022060792,
-0.041692063,
0.010095723,
-0.00710603,
-0.026208598,
-0.03383704,
0.0072382055,
0.01178254,
0.009126433,
0.00021144215,
0.004808686,
0.020204036,
0.01613805,
0.017560516,
-0.01719546,
-0.01435053,
-0.017170282,
0.0069675595,
-0.02494978,
-0.0057339175,
-0.008131967,
-0.001778081,
-0.009327844,
-0.02038027,
0.008087908,
0.008962787,
-0.013658179,
0.01147413,
0.0063633267,
0.003697779,
-0.0048055393,
0.012600772,
-0.0327041,
0.047860276,
-0.021651676,
0.0012123995,
0.023728726,
0.00097322394,
-0.023137081,
-0.012286067,
0.014325353,
0.006149328,
-0.0043083057,
-0.031143166,
-0.009365609,
0.008031261,
-0.01988933,
-0.017824868,
-0.028650707,
-0.00063491653,
-0.018907452,
-0.0048401565,
-0.0021368442,
0.0049565975,
-0.0061084162,
-0.00052791694,
0.009674019,
0.017799692,
-0.008862081,
-0.02190344,
-0.006652855,
0.005051009,
-0.01490441,
-0.00037744883,
-0.020569092,
0.052165434,
0.022130027,
0.028449295,
0.0022186674,
0.0026277835,
-0.04755816,
-0.0075151455,
-0.011455247,
0.029884348,
0.0041572475,
-0.0055734185,
-0.0038016315,
0.01261336,
-0.024030842,
0.02696389,
-0.020694975,
-0.022004144,
0.008232672,
0.0037292494,
-0.0045506284,
-0.015584172,
-0.010586662,
-0.012638536,
0.014602293,
0.0051737437,
0.0122168325,
-0.006715796,
0.017850045,
0.005872388,
-0.01178254,
0.0020864916,
-0.016830401,
-0.006640267,
-0.00096299604,
-0.030312346,
0.0023445492,
-0.0014059427,
-0.0021730352,
-0.027190477,
0.0021195353,
0.008843199,
0.008131967,
-0.011014661,
-0.035800796,
-0.026107892,
-0.025616953,
-0.029078703,
-0.001540479,
-0.0054915952,
-0.01684299,
0.024786133,
0.0007250007,
0.026510715,
-0.0120783625,
-0.0030164435,
0.013091711,
-0.0054380954,
0.005324802,
-0.0057937116,
-0.008685847,
-0.0030557816,
-0.0030164435,
-0.010970602,
-0.0029959877,
-0.026284128,
-0.014426058,
-0.018680865,
0.02384202,
-0.0058063,
-0.007074559,
-0.018328395,
0.0035183972,
-0.020795679,
0.002846503,
-0.005532507,
0.023615433,
-0.004113189,
0.008578847,
-0.008566259,
-0.02668695,
-0.0059290347,
-0.021135561,
-0.0032414573,
-0.0060391813,
0.026812831,
0.19103828,
-0.0000556142,
0.01774934,
0.0036820436,
-0.018756393,
0.023414021,
0.012235714,
-0.003634838,
-0.024597311,
0.010460781,
0.022293674,
0.010706251,
-0.01219795,
0.004981774,
0.018114395,
-0.025931658,
-0.027114948,
-0.017610868,
0.007590675,
0.004745745,
-0.011014661,
-0.006369621,
0.015911464,
-0.0037575727,
0.034743387,
-0.01482888,
-0.012235714,
-0.003502662,
0.040735364,
0.0073703816,
0.0010723559,
-0.020153683,
0.008415201,
0.034139153,
-0.001405156,
-0.025705071,
0.003829955,
-0.011272718,
0.012871418,
0.009938371,
-0.0012391494,
0.0035467208,
-0.030614464,
-0.01850463,
0.022860141,
0.010825838,
-0.0022249615,
-0.025340013,
0.02764365,
-0.01698146,
-0.029330468,
0.00022540716,
0.0063633267,
0.021664264,
-0.0064136796,
0.0023083582,
0.016515696,
0.020216623,
-0.005630065,
-0.011769951,
-0.009497785,
-0.014048413,
0.00403766,
0.04040807,
-0.023187434,
0.033308335,
-0.026737303,
-0.015269467,
0.010265664,
0.007685086,
0.017522752,
-0.044260055,
-0.03416433,
-0.0017355959,
-0.005570271,
-0.00987543,
0.012153891,
0.0152317025,
-0.0077291448,
0.0003066403,
-0.0068857362,
0.00017377594,
-0.026787655,
0.00608324,
-0.017094754,
-0.04441111,
0.0042264825,
0.009900606,
-0.009963548,
-0.02605754,
-0.004846451,
-0.020078152,
-0.013154652,
-0.0067598545,
0.04589652,
-0.00061249384,
-0.00824526,
-0.029632585,
-0.010076841,
-0.016087698,
-0.0023240934,
0.0819239,
0.040307365,
0.028726235,
-0.00935302,
-0.012600772,
-0.014854057,
0.006766149,
0.0043271882,
-0.009579608,
0.010548898,
-0.021248855,
0.0002326847,
-0.023200022,
0.0008095776,
0.020971915,
-0.009812489,
-0.017547928,
-0.008157143,
-0.023036376,
-0.016326874,
0.0065395613,
0.0048275683,
0.022432143,
-0.004056542,
-0.009403373,
0.0055923006,
0.011178307,
0.017661221,
-0.021790147,
0.007999791,
-0.012242009,
0.0066213845,
0.0019259921,
0.0090194335,
0.008786553,
-0.004459364,
0.0039338074,
0.0015436261,
0.01476594,
0.013142064,
0.011285307,
0.012884006,
0.029708114,
0.01136713,
-0.0024153579,
0.024899427,
-0.006026593,
-0.008673258,
-0.011549658,
-0.018617924,
-0.006778737,
0.008723611,
-0.01636464,
0.030387875,
-0.022268496,
-0.008773964,
-0.005409772,
-0.011493011,
0.0028606646,
-0.02342661,
0.018894864,
0.021639088,
-0.014602293,
-0.002190344,
-0.005085626,
-0.15377726,
0.026561068,
0.008748787,
0.018542394,
0.018215101,
-0.0045537753,
0.018806746,
-0.009900606,
-0.012833653,
0.013683355,
0.030614464,
-0.0068794424,
-0.002064462,
0.004723716,
-0.0050258324,
0.008024967,
-0.00887467,
0.0035058092,
0.021475442,
0.006797619,
0.006287798,
-0.020606857,
0.021865675,
-0.03610291,
0.005293331,
0.005013244,
-0.0014114501,
0.035901498,
-0.015294643,
0.0021399911,
-0.008887257,
-0.012707772,
0.036329497,
-0.015508642,
-0.02633448,
-0.010995778,
-0.025327425,
-0.04033254,
0.006372768,
0.022570614,
0.018454278,
0.039728306,
0.0072885584,
0.007943144,
0.002506622,
0.004931421,
0.002909444,
-0.012254597,
-0.012349009,
0.0055954475,
0.017157694,
-0.027391888,
0.0034554563,
0.007754321,
-0.010083135,
-0.003958984,
-0.034214683,
0.030689992,
0.019297685,
-0.015999582,
-0.020078152,
-0.00946002,
0.022570614,
0.027140124,
0.036203615,
-0.01153707,
0.016553462,
-0.010687368,
-0.022356614,
0.015886288,
-0.011700717,
-0.054582365,
0.027114948,
-0.003110855,
0.03778973,
0.008761376,
-0.015483466,
0.0021761823,
-0.0041415123,
0.011845481,
-0.022281084,
0.00030683697,
-0.017484987,
-0.035322443,
-0.014640057,
0.004739451,
0.0036128087,
0.0011557526,
-0.017623458,
-0.003556162,
0.012349009,
-0.039879367,
0.0030872521,
0.009415962,
-0.025742836,
0.010567781,
0.0009708637,
-0.00608324,
-0.0102090165,
0.009038316,
0.01858016,
-0.015269467,
-0.002774121,
0.020329917,
0.027014242,
0.015710054,
-0.005620624,
0.001507435,
0.02016627,
-0.03008576,
-0.010750309,
0.0057528,
0.021928616,
0.021878263,
0.010158665,
0.017585693,
-0.0008795993,
-0.010108312,
0.029305292,
-0.03851984,
0.059365876,
0.0042925705,
-0.010976897,
0.03431539,
0.02307414,
-0.0143631175,
-0.12316279,
-0.03277963,
0.020619445,
0.0031517665,
0.019901918,
0.026561068,
-0.0009968268,
0.0013264798,
0.0025349455,
0.021538382,
-0.008358554,
0.00011722746,
0.01601217,
-0.020229211,
0.056797884,
0.017082166,
0.002807165,
-0.010706251,
-0.030815873,
0.024974957,
-0.028952822,
-0.0043932763,
-0.021815322,
-0.019864153,
0.0011604732,
-0.0031942516,
-0.0026466656,
0.027014242,
0.0064829146,
-0.008050144,
0.03325798,
0.013079123,
-0.02093415,
0.0033421628,
-0.0024326665,
-0.010221605,
-0.0037953374,
-0.01975086,
0.05906376,
-0.015433113,
0.010630721,
0.012468596,
0.01531982,
0.004997509,
0.021022268,
-0.019310273,
-0.04317747,
0.036908556,
-0.0053877425,
-0.018819334,
-0.027291182,
-0.035775617,
-0.016679343,
0.0073577934,
0.020418033,
-0.03645538,
0.010964308,
0.021752382,
-0.030689992,
-0.02265873,
-0.020216623,
-0.00004887756,
0.0023571374,
0.012726653,
0.0065647378,
-0.019801212,
-0.0022642994,
-0.014249824,
0.010303428,
-0.03660644,
0.010693662,
0.005019538,
-0.011184601,
0.02218038,
-0.023250375,
0.0125378305,
-0.00021104877,
0.011555953,
-0.004380688,
-0.020984503,
-0.01822769,
-0.0064073857,
0.022142615,
0.02708977,
0.04488946,
0.008786553,
0.017686399,
-0.0103915455,
0.018101808,
-0.013456768,
-0.005620624,
0.003285516,
0.012965829,
-0.023766492,
-0.016037347,
-0.0016899636,
0.009497785,
-0.038847134,
-0.011002072,
0.0028512236,
0.0021478587,
-0.020342505,
-0.029708114,
0.011077601,
-0.0025931657,
0.000045091267,
0.008446671,
-0.008478141,
0.010316016,
-0.003093546,
0.014715587,
0.0020204035,
-0.025113426,
-0.002401196,
0.022243321,
-0.004390129,
-0.037437256,
-0.01435053,
0.01586111,
0.019599803,
0.0098439595,
0.0031423254,
0.0037638668,
0.017346516,
-0.01739687,
0.04151583,
0.011524482,
-0.027895415,
-0.003968425,
0.023577668,
-0.020178858,
-0.023036376,
0.008969081,
-0.027568122,
0.0025978864,
0.0043460703,
-0.015621936,
-0.014426058,
-0.024093784,
0.0331321,
0.009397079,
0.01662899,
-0.009648843,
-0.010309722,
0.016263934,
-0.01413653,
0.0007926622,
0.0071815588,
-0.038973015,
0.01413653,
0.008390024,
-0.015508642,
0.007351499,
-0.008862081,
-0.023414021,
-0.025113426,
-0.02917941,
0.036782674,
-0.001250164,
-0.029758466,
0.014451235,
0.016339462,
0.027945768,
-0.0074270284,
0.0060863867,
-0.0036191028,
-0.018416513,
-0.0024657105,
-0.0014924866,
0.014640057,
0.0062657683,
0.0116126,
-0.008855787,
0.00765991,
-0.010441898,
0.01531982,
0.040231835,
0.02779471,
-0.011914716,
0.01524429,
0.0005908579,
0.0023036376,
0.010139782,
0.0074459105,
-0.02106003,
0.014992527,
0.038091842,
-0.00741444,
-0.0024845928,
0.04008078,
0.012393067,
0.0116126,
-0.01774934,
0.015911464,
-0.007269676,
0.02473578,
0.015307232,
0.015810758,
-0.012411949,
0.0016223022,
0.0019071099,
0.026712125,
0.00029346204,
0.014841469,
-0.011297895,
-0.023036376,
0.0060580634,
0.0116692465,
-0.023703549,
-0.02176497,
-0.01469041,
-0.0019275657,
0.01878157,
0.020619445,
-0.010322311,
0.013192416,
-0.0044813934,
0.0084277885,
-0.018328395,
-0.0069109127,
-0.00075450423,
0.020480976,
-0.0055860067,
0.013695944,
-0.00020013245,
0.025679894,
0.0035939266,
0.021034855,
0.029985053,
-0.0019968005,
-0.0018913746,
0.0053751543,
0.009623666,
0.0021321236,
-0.014010648,
-0.016553462,
0.0063350033,
-0.024836486,
0.000070316804,
0.017799692,
0.008698435,
0.06419974,
0.015772995,
-0.0011470983,
0.019033333,
-0.0066780313,
0.01636464,
0.0014633763,
0.0059951223,
-0.018076632,
-0.012745536,
0.009837666,
-0.00013591304,
0.013091711,
-0.03799114,
-0.007187853,
0.02870106,
0.009686607,
-0.00962996,
0.020493563,
-0.010265664,
-0.0025774306,
0.0053122137,
0.010775485,
-0.011247542,
-0.021739794,
-0.015156173,
0.039980073,
-0.028978,
-0.010542604,
0.0027536652,
0.008566259,
0.01250636,
-0.036203615,
-0.015533819,
0.048816975,
-0.005416066,
-0.017333928,
-0.01662899,
-0.0010935984,
-0.0061272983,
-0.02106003,
0.013796649,
-0.0026592538,
-0.017522752,
-0.023313316,
-0.013972884,
-0.0015514937,
0.0062657683,
-0.023854608
] |
Long noncoding RNAs (IncRNAs) are increasingly implicated in cancer biology, contributing to essential cancer cell functions such as proliferation, invasion, and metastasis. In prostate cancer, several lncRNAs have been nominated as critical actors in disease pathogenesis. Among these, expression of PCGEM1 and PRNCR1 has been identified as a possible component in disease progression through the coordination of androgen receptor (AR) signaling (Yang et al., Nature 2013, see ref. [1]). However, concerns regarding the robustness of these findings have been suggested. Here, we sought to evaluate whether PCGEM | [
-0.008228289,
-0.02144423,
0.010675439,
-0.033286564,
-0.002567173,
-0.013936081,
-0.026538566,
0.01390941,
-0.042568393,
0.014629551,
0.009495205,
-0.004087473,
0.0045842375,
-0.0019103767,
-0.0022021008,
0.0009301834,
0.021777628,
-0.0013752712,
0.0059044976,
0.019977273,
-0.025418345,
-0.010828802,
-0.0085616885,
-0.024084749,
-0.0026455217,
0.0248449,
0.014322824,
-0.034406785,
0.008074925,
-0.01863034,
0.010155336,
0.012722509,
-0.008434997,
-0.013629355,
-0.022884512,
-0.0023971393,
0.012842532,
0.004067469,
0.02131087,
-0.0233246,
0.029445807,
0.004674255,
0.0033840006,
-0.013502663,
0.008214953,
-0.013636022,
0.0045442292,
0.0011677303,
-0.02048404,
0.016936673,
0.010502071,
0.013382639,
-0.024058077,
-0.005921168,
-0.012842532,
-0.008214953,
0.00091851444,
0.05361057,
0.008615032,
-0.0073947916,
-0.001810357,
-0.004697593,
-0.017336752,
0.028218897,
-0.010855474,
0.020577392,
-0.0078748865,
-0.002217104,
0.0044142036,
-0.00022796162,
0.04624912,
0.019603865,
-0.0070147165,
0.008174946,
0.004254172,
-0.029365791,
-0.020337343,
0.0030189287,
-0.0014677894,
0.0019520515,
0.0075481553,
-0.008441664,
0.003594042,
0.019243795,
0.0024171432,
-0.0002940163,
-0.016096508,
0.0033289897,
0.017856855,
-0.014922943,
0.034006707,
0.022751153,
0.022951193,
0.012562477,
-0.009628565,
-0.0045608995,
0.008388321,
0.01668329,
0.0003438178,
-0.029392462,
0.0020053955,
0.02645855,
-0.020817438,
0.000009559177,
-0.022377746,
-0.0048709605,
0.00071472424,
-0.010662102,
0.03088609,
0.004274176,
-0.030832747,
0.020030616,
0.0077281906,
-0.017483447,
0.0314462,
-0.027632115,
0.030939434,
0.0060611954,
-0.013342631,
-0.01889706,
0.012582481,
0.0002485907,
0.012495797,
-0.02497826,
0.019897256,
0.00645794,
-0.005391063,
0.0026771945,
0.0031039454,
-0.006021187,
0.007254764,
-0.0031789602,
0.018363621,
0.016109843,
-0.024738211,
0.0004921804,
-0.0029139079,
-0.025578378,
-0.010535411,
-0.027338725,
-0.008394989,
0.031072794,
-0.019870585,
0.006087867,
-0.03227303,
0.009321838,
0.0124824615,
-0.0063479184,
0.032619767,
0.016656619,
0.009788597,
0.015296349,
0.015869796,
-0.040141247,
-0.013142591,
0.015376366,
-0.0014144456,
0.0375274,
-0.011128861,
-0.019910593,
0.02312456,
0.013302623,
0.015803115,
0.021977667,
0.010208679,
0.024684867,
-0.002520497,
0.007108068,
-0.008761727,
-0.0015553067,
0.021137502,
-0.00035507002,
-0.037767448,
0.030165948,
-0.015656421,
0.004034129,
-0.025845096,
0.019643873,
-0.025791753,
-0.022337738,
0.0031106134,
0.0019053757,
0.02236441,
-0.017483447,
-0.024591517,
0.00039966215,
0.031366184,
-0.008855079,
-0.027498756,
-0.004434208,
-0.007881554,
0.011282225,
0.01357601,
-0.012349102,
-0.6217759,
-0.027898835,
0.026218504,
-0.015109646,
-0.0011944022,
0.014669559,
0.012369106,
-0.0052110273,
-0.023404615,
0.028165555,
-0.021417556,
0.006461274,
0.021390885,
-0.0066413097,
-0.004984316,
-0.045022212,
-0.016523259,
-0.007554823,
0.019310474,
-0.0011252218,
-0.016323218,
0.006621306,
0.02596512,
-0.00031652075,
-0.003607378,
0.02768546,
0.024564844,
-0.009141803,
0.017630143,
0.01274918,
-0.015696429,
0.021457564,
-0.0226578,
-0.019203788,
0.043528583,
-0.0061912206,
-0.0037940815,
0.021897651,
0.02104415,
0.045368947,
-0.002195433,
0.0066913194,
0.0034740183,
0.0066013015,
-0.034246754,
0.022044348,
-0.005307713,
0.0042375023,
-0.0052777072,
-0.0080349175,
-0.00038653455,
0.015349694,
-0.017790174,
-0.020404024,
-0.009108462,
-0.001800355,
0.038967684,
-0.02701866,
0.006127875,
-0.003987453,
0.010415387,
0.014909606,
-0.028432272,
-0.018870387,
-0.0019303806,
0.021244189,
-0.014256145,
-0.0073747877,
-0.008094929,
0.0016094841,
0.004680923,
0.042221658,
0.0019870584,
0.0049176365,
0.016709961,
0.045795698,
-0.0110155055,
0.014576208,
-0.002517163,
0.008915091,
0.0042174985,
-0.008154942,
-0.04195494,
0.01578978,
0.027365396,
-0.00063512527,
-0.019630538,
0.00848834,
0.0045442292,
-0.003977451,
0.013736042,
-0.0101886755,
-0.015456381,
-0.03379333,
0.001100217,
0.011762319,
0.005027658,
0.015176326,
0.0033573287,
-0.03462016,
-0.00041779072,
-0.008641704,
0.0067046555,
-0.010635431,
0.021950996,
-0.015363029,
-0.020950798,
0.022511106,
0.026271848,
-0.020897454,
0.001802022,
-0.012742513,
0.0041274806,
-0.015376366,
-0.021777628,
-0.026525231,
-0.0029672517,
0.017723495,
-0.00006094952,
-0.02781882,
0.010695443,
-0.0026771945,
-0.0010927154,
-0.011635628,
0.031739593,
-0.002137088,
0.0033639967,
-0.012962556,
0.017496783,
-0.00931517,
0.015403037,
-0.029472478,
0.0066013015,
-0.021017477,
0.00563111,
0.007641507,
0.017256737,
0.014029433,
0.016990017,
-0.04128814,
-0.03544699,
-0.019083763,
0.014056105,
0.0037374035,
-0.0062378966,
-0.021417556,
-0.021004142,
-0.0038807653,
0.021150837,
0.008014914,
0.014709568,
-0.023497967,
-0.004000789,
0.029152416,
0.008321641,
-0.0067946734,
-0.0052710394,
-0.011969027,
-0.010815466,
-0.02497826,
-0.0049176365,
0.009935292,
-0.029979246,
0.0037874135,
0.010782126,
-0.012249082,
0.015389701,
0.044648804,
-0.008168277,
-0.020737423,
0.006921365,
0.005771138,
-0.0035406982,
0.016789978,
0.01281586,
-0.0037440716,
-0.016709961,
-0.0038307554,
0.0060245213,
0.005111008,
0.009808601,
-0.01037538,
-0.015443045,
-0.0063779242,
0.018923732,
0.029392462,
0.051316787,
0.0064246003,
0.012555809,
0.016083172,
-0.04054133,
0.022737818,
-0.027872162,
0.02596512,
0.0044175377,
-0.025738409,
0.0066379756,
0.012122391,
-0.006697987,
0.0038540934,
0.0041908263,
-0.015136318,
-0.001827027,
-0.022484433,
0.017056696,
-0.01612318,
0.014976286,
0.0012969224,
0.007528151,
-0.0020887451,
-0.0015811451,
0.0150029585,
-0.008001578,
0.011255553,
-0.00951521,
0.02632519,
-0.014442848,
-0.0020687412,
0.0034406784,
-0.019017084,
-0.022391083,
0.015042966,
0.0019237127,
-0.013135924,
-0.017710159,
0.0029655849,
0.004290846,
-0.0033356578,
-0.0063679223,
-0.010475399,
-0.018016886,
0.03723401,
-0.00028213896,
-0.000113251495,
0.0004692592,
-0.0055044186,
0.023831366,
-0.0095018735,
0.025218306,
-0.00812827,
-0.028165555,
-0.0004154986,
-0.0026471887,
0.0067913393,
0.010435391,
-0.020070624,
0.022204379,
0.026791949,
-0.0023071216,
0.027925506,
0.0011035509,
0.030486012,
-0.021524245,
0.016323218,
0.007214756,
-0.008248293,
0.017763503,
0.014216136,
0.065559596,
0.021390885,
-0.003637384,
-0.013762713,
0.0019770565,
-0.008701716,
-0.015656421,
-0.0058811596,
0.0498765,
-0.019857248,
-0.0037040638,
0.019350482,
-0.001418613,
-0.0098219365,
0.002178763,
-0.030859418,
0.009028447,
0.017616807,
0.010995502,
0.00934851,
0.014389504,
0.0021354211,
-0.0059445053,
-0.033553284,
0.04288846,
0.020297335,
-0.020684078,
-0.024191437,
-0.044808835,
0.011248885,
-0.006091201,
-0.012935884,
0.001294422,
0.027005326,
0.0033073188,
0.007881554,
0.011148865,
-0.008414993,
0.015589741,
0.004110811,
0.016603274,
0.010595422,
0.015323021,
-0.0062845726,
0.0038574273,
-0.018576996,
0.03422008,
-0.0051243436,
-0.0095018735,
-0.009915289,
-0.008328309,
-0.010535411,
-0.0038640953,
0.007601499,
0.015082974,
-0.034993567,
0.015509725,
-0.0042475043,
0.023898046,
-0.018016886,
0.009121799,
0.0110155055,
-0.014896271,
-0.038994357,
0.0012369106,
0.015896467,
0.019870585,
0.02768546,
-0.0038907672,
0.009935292,
-0.010035312,
0.0041408166,
-0.02464486,
-0.005724462,
0.002932245,
-0.02249777,
-0.0060278554,
0.02187098,
-0.00042216657,
-0.0015244673,
0.013556006,
0.030459339,
0.00056177744,
-0.035927083,
-0.023537975,
-0.016856657,
0.019750562,
-0.0026821955,
0.032433063,
0.039394435,
0.035260286,
-0.019270467,
0.014416176,
-0.006954705,
0.016589938,
-0.018843716,
-0.016163187,
0.0048842966,
-0.017403431,
-0.0060611954,
0.0077882023,
-0.016776642,
0.018937068,
0.018723693,
-0.0008901755,
-0.02229773,
0.028485617,
0.0187637,
0.03984786,
-0.015736436,
0.0043608597,
-0.0048042806,
-0.0058611557,
0.015883133,
0.0074948114,
-0.009181811,
0.0038040834,
-0.008828407,
-0.0016686624,
-0.019017084,
0.01684332,
0.005411067,
-0.003267311,
-0.006421266,
0.0034773524,
-0.008708384,
-0.0011927352,
-0.008695048,
0.009508542,
-0.011742315,
-0.0106487665,
-0.02771213,
-0.014282816,
-0.009141803,
-0.02223105,
0.0023971393,
0.0065479577,
-0.041741565,
-0.017296745,
0.002860564,
0.017763503,
0.0027922173,
0.02701866,
-0.016216531,
-0.0047809426,
0.029392462,
0.006084533,
-0.027365396,
0.00029297444,
-0.033980034,
0.018350285,
-0.014322824,
-0.015323021,
-0.0074347993,
-0.022897849,
-0.008748392,
-0.0038107515,
-0.013242612,
0.030672714,
-0.01654993,
-0.006744663,
0.022417754,
0.010875477,
0.016363226,
0.00037528234,
-0.0038874333,
0.010655435,
-0.032646436,
-0.032699782,
-0.036780585,
-0.002503827,
-0.011375576,
0.0047842767,
0.029232431,
-0.033393253,
-0.009301834,
0.013349299,
-0.0139494175,
-0.0062612346,
0.007254764,
0.017043361,
0.025445018,
-0.017390097,
0.0030189287,
-0.0049376404,
-0.00586449,
-0.007688183,
0.01232243,
0.030299308,
0.003287315,
-0.017616807,
0.02196433,
-0.011608955,
-0.002133754,
-0.012722509,
0.0041808244,
-0.0143628325,
0.038114183,
0.0096619055,
-0.026511895,
-0.0026388536,
-0.017883526,
-0.008708384,
0.0055677644,
-0.018390292,
-0.028272241,
-0.036193803,
0.00026671926,
0.010195344,
-0.0056377784,
0.021190844,
-0.028912367,
-0.018350285,
0.028085537,
0.017990215,
-0.0021804299,
-0.017363423,
0.0117489835,
-0.015629748,
-0.014096113,
0.0011243884,
-0.00954855,
0.006554626,
-0.0033689977,
0.038647622,
0.022484433,
0.0496898,
-0.007901558,
0.011255553,
0.029285775,
0.021084158,
0.000361738,
-0.0030989444,
-0.0002435897,
-0.016910002,
0.0011502268,
0.01288254,
0.016643282,
0.014069441,
-0.013569342,
0.0044242055,
-0.00716808,
-0.011515604,
-0.016389899,
0.0041208128,
-0.038540933,
-0.07356117,
0.013682698,
-0.004657585,
0.0011919017,
-0.032913156,
-0.0055844346,
0.016216531,
0.0045575653,
0.017830182,
-0.0353403,
-0.0018470308,
-0.004077471,
0.03253975,
-0.0037240677,
0.014509528,
-0.0056344443,
-0.010595422,
-0.008321641,
0.002177096,
-0.010988833,
-0.020457366,
0.036727242,
0.0076681785,
-0.02605847,
0.0031839611,
-0.0043841978,
-0.042061627,
-0.007908226,
0.018016886,
-0.013816058,
0.0016594939,
-0.010848806,
-0.022831168,
-0.03486021,
0.012149062,
0.007968238,
-0.008101597,
0.019603865,
0.013295955,
-0.03101945,
0.013042572,
-0.00017951457,
0.0127558485,
-0.011482264,
0.0068146773,
0.024671532,
-0.006464608,
-0.022671137,
0.0044808835,
0.0010026977,
-0.0015536397,
0.02715202,
0.021364212,
-0.01222241,
-0.0059445053,
0.016696626,
0.0073147756,
-0.020377351,
-0.031232825,
0.035633694,
-0.0095018735,
0.0056944564,
-0.009561885,
-0.017830182,
-0.009915289,
-0.02795218,
-0.018910395,
0.014282816,
-0.0060011833,
0.0031539553,
-0.014749575,
0.008615032,
-0.0009901952,
0.009095127,
-0.0015686427,
-0.01965721,
-0.029525822,
-0.006131209,
0.008575024,
0.012009035,
-0.012149062,
0.02200434,
0.011588952,
-0.007121404,
0.011849003,
-0.0012035706,
0.014736239,
-0.011248885,
-0.019750562,
0.04155486,
-0.020097297,
-0.007974906,
0.02797885,
-0.0044375416,
0.026111815,
0.0062612346,
0.002533833,
-0.005034326,
-0.03616713,
-0.013816058,
0.017403431,
0.014176128,
-0.015269678,
-0.012782521,
-0.021710947,
0.020297335,
-0.01863034,
-0.017563464,
0.009655237,
-0.03486021,
-0.006074531,
-0.00882174,
0.026645254,
0.024498165,
0.02616516,
-0.00021170841,
-0.0035340302,
0.0322997,
-0.012502465,
0.02388471,
-0.005074334,
-0.026925309,
-0.00080932624,
0.029152416,
-0.012762517,
-0.040354624,
0.0233246,
-0.028485617,
-0.020364016,
0.013282619,
-0.020257328,
0.03432677,
0.0046142433,
-0.0022021008,
0.014749575,
0.0214709,
0.0054477407,
0.014389504,
-0.0023437955,
0.012122391,
-0.021150837,
-0.007188084,
0.0110155055,
0.011515604,
-0.00088934205,
-0.03502024,
0.006074531,
0.016363226,
-0.0019403826,
-0.0039141052,
-0.02243109,
-0.006064529,
-0.006464608,
-0.00047926116,
-0.0030689384,
-0.006921365,
-0.021204181,
0.031926297,
0.008901755,
-0.0001433616,
-0.012549141,
0.01066877,
0.011508936,
0.017043361,
-0.021630932,
0.01159562,
-0.0074281315,
-0.028832352,
-0.040648017,
0.005791142,
-0.023724679,
0.040834717,
0.000907679,
-0.016603274,
-0.034726847,
-0.009655237,
-0.028565632,
-0.04043464,
-0.002155425,
0.029712526,
0.002117084,
0.02075076,
0.0020187313,
0.008921759,
0.0024704873,
0.003987453,
0.006731327,
-0.0117489835,
0.003917439,
-0.0016928338,
0.013175932,
0.009668573,
-0.02444482,
-0.012415782,
0.038647622,
0.025605049,
-0.030726058,
0.027578771,
-0.012315762,
0.015696429,
-0.028618976,
-0.020203983,
0.0007722356,
0.017683487,
0.027005326,
-0.019710554,
-0.02949915,
0.033286564,
0.00057219615,
-0.009648569,
0.032379717,
-0.013009232,
0.013275951,
0.00360071,
0.0031206154,
-0.027205365,
0.0366739,
-0.00091267994,
0.018350285,
0.03197964,
0.019510513,
0.032619767,
0.0041441503,
-0.008861748,
-0.03267311,
-0.0314462,
-0.015776444,
-0.013362635,
0.023791358,
0.004810949,
-0.034886878,
0.002567173,
-0.0063012424,
-0.01172898,
-0.022151034,
0.008374984,
-0.0026221836,
-0.009995304,
0.011755652,
-0.011348904,
-0.020710751,
0.0053477213,
0.0014361165,
-0.013656026,
-0.035660364,
-0.005077668,
-0.020430695,
-0.004687591,
0.011802327,
-0.0023421284,
-0.0074814754,
-0.00045425625,
-0.016829986,
0.0030972774,
0.009461866,
0.002483823,
0.199506,
-0.012375774,
-0.019990608,
-0.0049709803,
-0.0030005916,
-0.019470505,
0.0072681,
-0.008234957,
-0.012635825,
0.008661708,
0.027218701,
0.012995896,
-0.037740774,
0.0030806074,
0.022644466,
-0.003620714,
-0.019470505,
-0.011555612,
-0.029872557,
0.0049476423,
0.004434208,
-0.007308108,
-0.0008651706,
-0.027192028,
0.02547169,
-0.004374196,
-0.015269678,
0.0052477014,
0.021577587,
0.007948234,
-0.040754702,
0.017696822,
-0.010675439,
-0.008348313,
-0.007508147,
0.016990017,
0.0077148546,
0.0076681785,
-0.00589783,
-0.027272044,
-0.0058711576,
0.0041308147,
-0.0028238902,
-0.009881949,
0.02252444,
0.0024788221,
-0.0037340696,
0.000632208,
-0.008575024,
-0.001830361,
-0.05166352,
0.01225575,
0.0023704674,
0.030405996,
-0.000725143,
0.006101203,
-0.003910771,
0.004040797,
0.0016736634,
0.013042572,
-0.014802919,
-0.007954902,
-0.017096704,
-0.004660919,
-0.02117751,
0.042488378,
-0.01090215,
0.010535411,
0.016443243,
-0.024324797,
-0.001817025,
-0.0044242055,
-0.0075814947,
0.004007457,
-0.012902544,
-0.006117873,
0.03891434,
0.007808206,
0.018443637,
0.01684332,
0.021991003,
0.0048509566,
-0.0241781,
-0.011035509,
-0.010488735,
-0.02768546,
0.01979057,
-0.0056577823,
-0.023364607,
-0.021924322,
0.012062378,
-0.023524638,
-0.0022187708,
-0.0036907278,
0.01883038,
-0.0072947717,
-0.009715249,
0.010448727,
0.0023871374,
-0.02540501,
-0.039554466,
0.08268297,
0.021684276,
0.017656814,
-0.020724086,
0.0077015185,
0.002165427,
0.014096113,
-0.0023121226,
0.0007943233,
0.0004350858,
-0.00944853,
0.019363819,
-0.020577392,
0.0034273425,
0.005101006,
0.015656421,
-0.020870782,
0.010955494,
-0.013696034,
-0.02715202,
-0.030512683,
-0.013856065,
0.02173762,
-0.018870387,
0.0012852534,
-0.00056969567,
-0.0066579795,
-0.009781929,
-0.017896863,
-0.0045342273,
-0.019577194,
0.0020420693,
-0.027445411,
0.0067513315,
-0.011922351,
0.024898242,
-0.0030239297,
0.0013377637,
-0.0066446434,
-0.0052343654,
-0.008068258,
0.004077471,
0.018483644,
-0.011949023,
-0.008208285,
0.011068849,
0.026231838,
-0.00074264646,
-0.0011210544,
-0.032619767,
-0.011102189,
0.0014769579,
0.024898242,
0.029285775,
-0.009875281,
-0.016576601,
-0.049076345,
-0.002487157,
0.012795856,
-0.027338725,
0.0018536989,
0.029739197,
-0.01308258,
0.0010135332,
0.014602879,
-0.16803314,
0.0024571512,
0.016069835,
-0.031739593,
0.016323218,
0.029685853,
-0.010615426,
-0.015336357,
0.0015436377,
0.00042925132,
0.01288254,
-0.01222241,
-0.030726058,
-0.025551705,
0.017443439,
0.010395383,
0.0146828955,
0.027578771,
0.020097297,
0.018043557,
0.01849698,
-0.022084355,
0.0064712763,
-0.013736042,
-0.030566027,
-0.008628368,
-0.0035473662,
-0.026391871,
-0.031792935,
-0.009028447,
0.0029689188,
0.0011718977,
0.02187098,
-0.012295758,
0.016749969,
0.001830361,
-0.010162004,
0.011875675,
-0.008394989,
-0.009561885,
0.032966502,
0.040728033,
0.0063945944,
0.020110631,
-0.013389307,
0.015896467,
0.025258314,
-0.02715202,
0.032806467,
0.006077865,
0.019843914,
-0.009628565,
0.029952573,
-0.0029922568,
0.009555218,
0.023577983,
-0.000057302965,
0.015456381,
-0.0010860475,
-0.008234957,
-0.0063912603,
-0.02701866,
0.023417952,
0.0025571708,
0.022817833,
-0.032486405,
-0.0034706844,
0.02824557,
-0.023497967,
0.015749773,
-0.028618976,
-0.015683092,
0.009015111,
-0.026005128,
0.030992778,
-0.0038674292,
-0.012402446,
0.035687037,
-0.016709961,
0.0004154986,
-0.0010977165,
0.0076948507,
-0.007321444,
-0.017923534,
0.0035073583,
-0.027312052,
0.018283606,
0.036513865,
-0.002503827,
-0.00030172616,
0.033019844,
-0.014082777,
0.006467942,
-0.013762713,
0.000020746278,
0.021190844,
0.0077681984,
-0.018083565,
0.000322772,
-0.040514655,
0.0366739,
-0.024618188,
-0.019003747,
-0.0019187117,
0.025124954,
0.011688972,
-0.0151629895,
-0.021217518,
0.044062022,
-0.035953756,
-0.0033306568,
0.004710929,
0.0019603865,
0.0241781,
-0.0063845925,
0.02784549,
-0.009555218,
-0.010268692,
-0.0017536791,
-0.020150641,
0.05398398,
-0.0012835865,
0.008254961,
0.0075148153,
0.0015244673,
-0.025791753,
-0.108021304,
-0.021164173,
0.019150443,
0.03867429,
-0.031792935,
0.038034167,
-0.013102584,
0.006774669,
-0.035527006,
0.041528188,
-0.020364016,
-0.008048254,
0.005374393,
0.014989623,
0.008394989,
-0.014242808,
-0.008181613,
-0.028325586,
-0.003260643,
0.037073977,
0.007901558,
-0.00025609217,
0.0026655255,
-0.034033377,
0.009961965,
0.021524245,
-0.020657407,
-0.002138755,
0.015869796,
-0.004364194,
-0.006184553,
-0.005674452,
0.020497374,
0.0031689582,
-0.03766076,
-0.0062845726,
-0.007641507,
-0.017750166,
0.041581534,
0.006231229,
0.014776247,
0.0074948114,
-0.014576208,
0.014816255,
0.003267311,
-0.011635628,
-0.010708778,
0.020564055,
0.007441467,
-0.026831958,
-0.03133951,
-0.02893904,
-0.012142395,
-0.017830182,
0.022964528,
-0.011949023,
0.014189465,
0.052783743,
-0.0009776928,
-0.019750562,
-0.021390885,
0.002888903,
-0.017070033,
0.0029555827,
0.016829986,
-0.004324186,
-0.006107871,
-0.03101945,
0.023631327,
-0.016536593,
-0.014722903,
0.0045408956,
-0.024484828,
-0.016096508,
-0.021084158,
0.0031256163,
-0.0068813567,
-0.019963937,
0.01397609,
-0.026351864,
-0.018550325,
-0.030832747,
0.02256445,
-0.021764291,
0.021617597,
0.005761136,
0.0041741566,
-0.013502663,
-0.0044675474,
-0.019083763,
-0.020790767,
0.030912763,
0.0021004141,
-0.018456973,
-0.008895087,
-0.0034840202,
-0.017003354,
-0.008541685,
0.004694259,
0.016389899,
-0.028432272,
-0.0028422272,
-0.06513284,
0.005467745,
-0.0146828955,
-0.006784671,
0.016163187,
-0.046489168,
0.009881949,
-0.012162399,
0.0051810215,
0.019630538,
-0.007608167,
0.035633694,
-0.0033656636,
0.003930775,
-0.010708778,
-0.000101061596,
0.025298322,
0.0033273227,
0.010462063,
0.036620554,
-0.010855474,
0.015976483,
-0.006161215,
0.0106487665,
0.004810949,
-0.020257328,
-0.00020993724,
0.014389504,
-0.02252444,
-0.018923732,
-0.0028572301,
-0.031126138,
-0.02077743,
-0.008895087,
-0.016656619,
-0.016389899,
0.0019320477,
0.046089087,
0.019163778,
0.053583898,
-0.00792823,
-0.03862095,
0.022671137,
0.0066913194,
0.013429315,
-0.0005888661,
-0.032166343,
-0.010302031,
0.010682106,
0.016643282,
0.029872557,
0.009001775,
0.0042375023,
-0.027605444,
-0.0020704083,
-0.02160426,
-0.0077415267,
-0.012002367,
-0.011068849,
0.00802825,
0.020430695,
0.0381942,
0.00447755,
-0.001100217,
0.01903042,
0.0030606035,
-0.03627382,
-0.0076148347,
0.017683487,
-0.0050376602,
-0.0135360025,
-0.0007447302,
0.0060711973,
-0.006467942,
0.0067946734,
-0.0026555236,
-0.013182599,
0.0006713824,
-0.007834878,
0.02312456,
0.018376958,
0.014722903,
0.0015619746,
0.011475597,
0.010362043,
0.002932245,
-0.006444604,
0.010568751,
0.0044575455,
0.009968632,
0.022204379,
0.013636022,
0.020670742,
0.02133754,
0.0007413962,
0.006874689,
-0.015696429,
0.029259102,
0.0049943184,
0.021991003,
0.023831366,
-0.010962161,
0.003238972,
-0.03227303,
-0.00029630843,
0.015616412,
-0.026685262,
-0.02375135,
0.021857643,
-0.0027988853,
0.0077081867,
-0.020257328,
-0.006801341,
-0.0040374626,
-0.012875873,
0.0055610966,
0.0065612937,
-0.012075715,
-0.011668968,
0.025284985,
0.01172898,
0.01856366,
-0.010068652,
0.019763898,
0.005487749,
0.01308258,
0.02140422,
-0.0031689582,
0.014456184,
-0.016523259,
0.008935095,
-0.020003945,
-0.040808048,
-0.0097085815,
-0.012269086,
0.0041674883,
0.017416768,
-0.0034173406,
-0.019697217,
0.08961767,
0.013609351,
-0.025818424,
0.025951784,
-0.017016688,
0.03984786,
0.0045042215,
-0.0077348584,
-0.020457366,
-0.0275521,
-0.013202603,
-0.027578771,
0.0054377387,
-0.04000789,
-0.005867824,
0.025605049,
0.012162399,
0.029232431,
-0.0157231,
-0.012722509,
0.014176128,
-0.014989623,
0.01076879,
0.023097888,
-0.030352652,
0.007628171,
0.024084749,
0.0067913393,
0.010061984,
-0.023911381,
0.01179566,
-0.0135826785,
-0.01968388,
0.023004536,
0.01281586,
-0.009288498,
0.0039274413,
-0.03504691,
0.019723888,
0.023204576,
0.012295758,
0.001636156,
-0.006421266,
-0.015122982,
0.02223105,
0.010035312,
-0.024098085,
0.00046842571,
-0.0027072006
] |
Aging is a complex organismal process that is controlled by genetic, environmental, and behavioral factors. Accumulating evidence supports a role for different cell cycle inhibitors in mammalian aging. Little is known, however, about the upstream signals that induce their expression. Here, we explore the role of p38MAPK by generating a dominant-negative allele (p38(AF)) in which activating phosphorylation sites Thr180 and Tyr182 are mutated. Heterozygous p38(AF) mice show a marked attenuation of p38-dependent signaling and age-induced expression of multiple cell cycle inhibitors in different organs, including pancreatic islets. As a result, | [
-0.034217566,
-0.021214891,
-0.00817196,
-0.028152335,
-0.026394492,
0.02631398,
-0.020060888,
0.024274344,
-0.029574713,
-0.02701175,
0.018303044,
0.0023532964,
0.016518362,
0.021952918,
-0.006417471,
0.010547061,
0.03738437,
-0.008668451,
0.0020899554,
0.0043275156,
-0.020101143,
0.036874462,
-0.0056358343,
-0.037250184,
-0.010426294,
0.027749775,
-0.0005401008,
-0.054050338,
-0.027239867,
-0.010030444,
0.0056727356,
-0.0021604032,
0.0064040525,
-0.011734612,
-0.0009040818,
-0.0055989334,
0.015109404,
-0.03137281,
0.011036842,
-0.011083808,
-0.00018828048,
0.014384797,
-0.008346402,
-0.01465317,
0.0065550124,
-0.0015867557,
0.013351561,
-0.0100505715,
-0.0029168797,
0.02482451,
-0.0046529183,
-0.008909986,
-0.0011556816,
-0.0016102385,
-0.0069776997,
-0.010486678,
-0.0012286454,
0.031345975,
-0.0019054489,
0.007849912,
-0.009446732,
-0.0047971685,
-0.028018149,
0.0040826253,
-0.009996897,
0.009802327,
0.014706844,
0.0050286404,
0.006558367,
0.0055855145,
0.037491716,
0.01655862,
-0.016115803,
-0.008742252,
0.0047200113,
-0.023979135,
-0.029037967,
0.0021251792,
-0.005404363,
0.013794376,
0.022878805,
-0.013928562,
0.0011305215,
0.03118495,
0.01555222,
-0.0019406728,
-0.0051359897,
0.012519604,
0.016384177,
0.014988636,
-0.0027021815,
0.018678766,
0.010513515,
0.04063168,
-0.00478375,
-0.019953538,
0.00408598,
0.018826371,
-0.013928562,
-0.0119090555,
-0.012539731,
-0.0054479735,
0.010372619,
-0.016169477,
-0.045274537,
-0.0075815395,
-0.013794376,
-0.0056492533,
0.01803467,
-0.018866627,
-0.017658949,
0.04033647,
0.0034955593,
-0.028340196,
0.015082567,
-0.009929804,
0.006058522,
0.016209733,
-0.011499786,
0.006588559,
0.009540663,
0.047770407,
0.03786744,
-0.01655862,
0.01944363,
-0.001997702,
0.016236572,
0.004377836,
-0.03789428,
-0.008098157,
0.01743083,
0.031265464,
0.005988074,
0.007957262,
-0.023791272,
-0.0048206514,
-0.017216133,
-0.020141399,
-0.006239674,
-0.042563967,
-0.010292107,
0.037115995,
-0.021738218,
-0.015015474,
0.0003144997,
0.013123443,
0.03427124,
0.0044482835,
-0.002507611,
-0.0045724064,
-0.0021503393,
0.004824006,
0.012197556,
-0.019175256,
0.0025260616,
0.02401939,
-0.009527244,
0.010902656,
-0.0069776997,
-0.0060316846,
0.010734923,
-0.00049313554,
0.016182896,
0.012512894,
0.021993173,
0.024368275,
0.008923405,
0.009144813,
0.0036096177,
-0.00642418,
-0.009077719,
0.019215511,
-0.003737095,
0.015605894,
-0.013901725,
0.0070246654,
-0.014881287,
0.025562536,
-0.014988636,
-0.023965714,
-0.016504943,
0.0014760519,
0.015391196,
0.017578436,
-0.009916385,
0.0007820559,
0.02062447,
-0.016330501,
-0.0044315103,
-0.00040486595,
-0.005572096,
0.0048307152,
-0.007085049,
-0.028044986,
-0.63679564,
-0.02761559,
0.015216753,
-0.0047401395,
0.0013636707,
0.02462323,
0.015498545,
0.008198798,
-0.027333798,
0.038108975,
-0.003817607,
0.03478115,
0.0015867557,
0.00021742412,
-0.026421329,
-0.02831336,
-0.012949001,
-0.030970253,
0.02482451,
-0.0011447789,
-0.015579057,
0.0012118722,
-0.0037236763,
0.015216753,
0.00787004,
0.024985533,
0.033653982,
-0.016518362,
0.0030929996,
0.038806748,
-0.017471086,
0.029252665,
-0.012103626,
-0.007554702,
0.050561488,
-0.01106368,
0.0056056427,
0.018115181,
0.0033915646,
0.03207058,
-0.0058840797,
0.022181034,
0.02750824,
-0.005213147,
-0.030782392,
0.01606213,
0.014800775,
-0.010640992,
0.016169477,
-0.012694046,
-0.0052768853,
0.01375412,
-0.02839387,
0.0005421975,
-0.0033144075,
0.011667519,
0.005840469,
-0.010647702,
0.00037488365,
-0.002229174,
0.0008613098,
0.052091215,
-0.010902656,
0.006216191,
-0.017081946,
0.017699204,
-0.029816248,
0.0040725614,
0.001064267,
0.013915144,
0.021899242,
0.027333798,
-0.017095365,
-0.004414737,
0.017806554,
0.007917006,
0.0035156873,
0.0014852772,
0.00067177135,
0.019470466,
0.009580919,
0.0048105875,
-0.035827804,
0.027535077,
0.018383555,
0.0016353984,
-0.02440853,
-0.0032456368,
-0.005840469,
-0.00008449559,
0.01145953,
-0.019779095,
-0.008782509,
-0.03896777,
-0.017967578,
0.018692184,
0.01684041,
0.0121841375,
-0.006511402,
-0.04116843,
-0.022368895,
0.00866174,
-0.00051368284,
-0.005461392,
0.031855885,
0.008856311,
-0.037947953,
-0.0031818983,
0.06811309,
-0.0024254217,
0.02541493,
0.0027826934,
-0.0029638452,
-0.015283846,
0.0034351754,
-0.01763211,
0.019510722,
0.0001287352,
0.016223153,
-0.009621175,
0.006011557,
-0.0018987395,
0.019846188,
-0.037840605,
0.022865385,
0.031345975,
0.0019591234,
0.0011649069,
-0.0059176264,
-0.001327608,
0.013687027,
0.0021302113,
0.010238432,
-0.021979755,
0.032661002,
0.008447043,
0.010855691,
0.0038779909,
0.01284836,
-0.031641185,
-0.03555943,
-0.0038410896,
-0.0031684795,
0.01465317,
0.0029839731,
-0.01096304,
-0.01653178,
0.010835563,
0.026622608,
0.005414427,
0.0073400037,
0.0015104372,
-0.008587939,
0.021563776,
0.0102988165,
-0.008534264,
-0.0059847194,
-0.028098661,
-0.005548613,
-0.008842893,
0.0030326156,
0.010124374,
-0.029333176,
0.0020916327,
-0.0044281557,
0.0016102385,
0.012942292,
-0.004753558,
-0.009211905,
-0.020087725,
-0.012506185,
-0.028125498,
-0.021174636,
-0.0038645722,
-0.00005702928,
0.011580298,
0.0075882487,
-0.003049389,
-0.017887065,
-0.013807795,
0.012915454,
-0.013613224,
-0.0014450212,
-0.0034922047,
0.041007407,
0.025066044,
0.028179172,
-0.0060954234,
-0.0077895285,
0.041785687,
-0.009540663,
0.017524762,
-0.0017310063,
0.016894085,
0.00036314232,
-0.036337715,
0.006544948,
0.014599496,
0.010634283,
0.034754314,
-0.0010877496,
-0.023898622,
0.019886445,
-0.0147471,
0.016826991,
-0.024301182,
-0.0060551674,
-0.021979755,
0.018356718,
0.017524762,
-0.008104866,
0.030514019,
-0.025683302,
-0.0055922237,
-0.008084739,
-0.0004969095,
-0.01076176,
0.0081652505,
-0.015176497,
-0.023643667,
-0.005548613,
0.0014240546,
0.011097226,
-0.020812333,
0.0015943038,
0.017900484,
0.0021721446,
0.030245645,
0.009755361,
-0.007467481,
-0.016706225,
0.0036934845,
-0.0048609073,
0.019805932,
-0.0108624,
0.008876439,
-0.009077719,
-0.0066724257,
0.055070154,
-0.0029302984,
0.0070649213,
-0.0039014735,
0.0005321335,
0.009272289,
0.011754741,
-0.006508047,
0.032473143,
0.018370137,
-0.008916696,
0.0034418846,
-0.012204265,
0.008118286,
-0.00007390743,
-0.009111266,
-0.003275829,
-0.012492767,
0.027145937,
0.0030510663,
0.03080923,
0.010822144,
0.014773938,
0.0055855145,
0.010842272,
-0.027830288,
0.0019054489,
0.009064301,
0.020382935,
0.007890169,
-0.00032477334,
0.016357338,
-0.030245645,
-0.00014267802,
0.0017477797,
-0.017095365,
0.014934962,
0.004324161,
0.004012177,
0.009325964,
0.026743377,
0.024448788,
-0.013096606,
-0.026662864,
0.030433506,
0.030460343,
-0.0034301432,
-0.018490905,
-0.00005147312,
-0.012908745,
-0.014760519,
0.005800213,
-0.009346092,
0.00085879385,
0.0045489236,
0.009057591,
-0.023080084,
0.00024216477,
0.023710761,
-0.018611673,
0.012278068,
0.0057364744,
-0.0032104128,
0.009077719,
-0.004196684,
0.002933653,
0.016733062,
-0.00084663316,
0.011452821,
-0.006534884,
-0.013076478,
-0.0209331,
0.008494007,
-0.013499166,
0.018557997,
-0.009601046,
0.0024556136,
-0.00030359704,
0.010533643,
-0.013767539,
0.018826371,
0.0059813648,
-0.009748652,
-0.0146800075,
-0.009426604,
-0.010030444,
0.027830288,
0.01693434,
0.010694667,
-0.007467481,
-0.0056358343,
0.01465317,
-0.009876129,
-0.030487182,
0.020772075,
-0.02650184,
-0.0102719795,
-0.006528175,
0.003104741,
-0.01315699,
0.018182276,
0.01873244,
-0.0018551289,
-0.029547876,
-0.002502579,
0.010674539,
0.023281364,
-0.02032926,
0.0138212135,
0.045086674,
0.049004924,
0.0025898002,
0.015927942,
0.030406669,
-0.0020748593,
-0.018262787,
-0.007246073,
0.0008520845,
0.008400077,
0.015860848,
0.0079706805,
-0.01693434,
-0.0009518857,
0.019591235,
0.017068528,
0.00003221001,
0.027749775,
0.012647081,
0.016330501,
0.0006545787,
0.007413806,
-0.01434454,
-0.0031567384,
0.01603529,
-0.008500717,
-0.014183517,
0.028876942,
-0.017471086,
-0.02232864,
-0.02750824,
0.009882838,
0.00787004,
0.008889858,
0.0027575332,
-0.0036096177,
-0.0014911479,
-0.0010399456,
-0.01445189,
0.014384797,
-0.026528679,
0.0059746555,
0.007890169,
0.010795306,
-0.02062447,
-0.0019960247,
-0.008856311,
0.008091448,
-0.015377777,
-0.018155439,
0.0033580181,
0.012841651,
0.025991932,
0.02191266,
-0.023147177,
-0.012942292,
0.017014854,
-0.004203393,
-0.005189664,
-0.031077601,
-0.03585464,
-0.006068586,
0.0047267205,
0.026944656,
-0.028286522,
-0.016585456,
0.004444929,
0.009540663,
-0.025549116,
0.027441146,
-0.016491525,
-0.02091968,
-0.006219546,
0.02440853,
0.034244403,
0.003519042,
-0.0008915018,
-0.00041870392,
-0.014129843,
-0.014183517,
-0.030406669,
-0.033815008,
-0.020758657,
0.005102443,
-0.008836184,
-0.016679386,
-0.009983478,
-0.016169477,
-0.0011313602,
-0.0037337404,
-0.0017477797,
0.00047678154,
0.015418033,
0.004894454,
0.005323851,
-0.012425673,
0.0021587259,
-0.019671746,
0.00046336287,
0.021295404,
0.001352768,
-0.026998332,
0.019712003,
-0.014975217,
-0.0034620126,
-0.021738218,
-0.014921543,
-0.014317703,
0.03767958,
0.013297886,
-0.023536319,
-0.024140159,
-0.0070313746,
-0.016021872,
-0.0157535,
0.005092379,
-0.009728524,
-0.0122109745,
-0.0018937074,
0.01366019,
-0.013619933,
0.024005972,
-0.03547892,
-0.010983168,
0.017980997,
0.008098157,
0.009097847,
-0.0036230364,
0.0009091138,
-0.012720884,
-0.0059679463,
-0.02750824,
-0.04116843,
0.01245251,
0.002745792,
0.035586268,
0.037545394,
0.01564615,
-0.009151522,
-0.0013309628,
0.036498737,
0.012049951,
-0.007682179,
-0.01684041,
0.042805504,
-0.016813572,
0.03867256,
0.012304906,
0.02301299,
0.015699824,
-0.024448788,
0.014720263,
0.004065852,
-0.0013292853,
-0.03118495,
-0.00031282238,
-0.03220477,
-0.034298077,
0.0104933875,
-0.030165134,
-0.01685383,
-0.036659762,
0.0017813263,
0.016719643,
0.019712003,
0.0116541,
-0.016880667,
0.007165561,
-0.0199267,
0.037089158,
-0.030487182,
-0.0032808608,
-0.005411072,
-0.027588751,
0.008084739,
0.023697343,
0.015592475,
-0.0036934845,
0.0003750933,
0.0042872597,
-0.022342058,
-0.002781016,
-0.000054146363,
-0.02034268,
-0.011077099,
-0.027696101,
-0.038216326,
-0.024958696,
-0.025294162,
-0.020060888,
-0.022717781,
0.00917165,
0.017390575,
-0.020463446,
0.020275585,
-0.0048978087,
-0.020584214,
0.014223773,
-0.0038209616,
0.040524334,
-0.0165452,
0.027561914,
0.030057784,
-0.0007757659,
-0.009815745,
-0.021080704,
-0.008004227,
0.025146557,
0.038431022,
0.01694776,
-0.0039014735,
-0.011392437,
-0.008239053,
0.014116423,
-0.010372619,
-0.026421329,
0.036498737,
-0.0015456611,
0.01146624,
0.0032473141,
-0.0047166566,
-0.041517314,
-0.002386843,
-0.014814193,
0.020986775,
0.00657514,
-0.02569672,
-0.017363738,
0.006846868,
0.000687706,
0.008816055,
0.014357959,
-0.043530114,
-0.0024405175,
-0.019135,
0.0294942,
-0.0039417297,
-0.00996335,
0.025294162,
-0.0054949387,
-0.0030510663,
-0.008299437,
-0.00997006,
0.017202714,
-0.0038209616,
-0.02023533,
0.04602598,
-0.00707834,
-0.005042059,
-0.0035458792,
-0.006749583,
-0.0155119635,
0.01066783,
0.0011581975,
-0.024287762,
-0.008339693,
-0.009057591,
0.02521365,
0.004495249,
-0.027669264,
0.012445801,
-0.023965714,
-0.008728834,
-0.015189916,
-0.029037967,
0.015297265,
-0.049004924,
-0.004870971,
-0.008078029,
0.007353422,
0.031345975,
0.017283225,
-0.011124064,
-0.000015371172,
0.02342897,
-0.025347836,
0.028474383,
0.0016312051,
-0.012492767,
-0.019457048,
0.027481403,
-0.025683302,
-0.01624999,
0.002058086,
-0.0069038975,
-0.03319775,
-0.00095691776,
-0.004743494,
0.015995035,
0.014331122,
-0.012170719,
0.018276205,
0.0019222221,
0.012137172,
0.0065617217,
0.0021553712,
-0.009708396,
-0.035827804,
0.012318324,
0.0048575527,
-0.026072444,
-0.022959316,
0.0070112464,
-0.019483885,
0.004974966,
0.0019440275,
-0.011969439,
-0.02401939,
0.0059176264,
-0.0045690513,
0.0010156244,
0.0075614112,
-0.017336901,
-0.026998332,
0.010734923,
-0.0077090166,
0.00737355,
-0.010479968,
0.009185068,
0.0037605776,
0.015914524,
-0.020356098,
-0.0028732691,
0.0025612854,
-0.039316654,
-0.034432266,
-0.003586135,
-0.03148016,
0.028554894,
0.014639751,
0.0067864843,
-0.033331934,
-0.010238432,
-0.022409152,
-0.028152335,
0.008447043,
-0.0052466937,
-0.0061893538,
0.017028272,
-0.01773946,
0.0057968586,
0.010580609,
0.016988015,
0.012076789,
-0.011540042,
0.0038410896,
-0.0015028892,
0.016075548,
0.00817196,
-0.011835253,
-0.015766919,
0.03988024,
-0.029252665,
-0.014532402,
0.022476245,
-0.027642427,
0.010037153,
-0.0129892565,
0.00030275836,
0.0086349035,
0.010399456,
0.026662864,
-0.014572658,
-0.0073400037,
0.016209733,
0.002331491,
-0.013915144,
0.003797479,
-0.0016655903,
-0.0044684117,
-0.016786736,
-0.004951483,
-0.025401512,
0.012774558,
-0.0069844094,
0.034539614,
0.053835638,
0.013687027,
-0.0016085611,
0.016478106,
-0.0074473526,
-0.022301802,
-0.0033194395,
-0.0067261,
-0.01296242,
-0.005152763,
0.007346713,
0.008507427,
-0.017001433,
0.0020899554,
-0.022945898,
-0.02332162,
-0.005015222,
-0.009158231,
-0.020557377,
0.02839387,
0.00052919815,
0.010318944,
-0.00021291629,
0.0009871097,
-0.0069776997,
-0.013009384,
0.0026770213,
-0.0016790091,
0.0019758968,
-0.00767547,
0.015418033,
-0.015981616,
0.0135998055,
-0.002432131,
-0.025777234,
-0.0060249753,
0.031131277,
0.18764645,
-0.0041530733,
0.013519294,
0.0037438043,
-0.0029453945,
0.021765057,
0.019712003,
-0.0011766482,
-0.014398215,
-0.004314097,
0.016075548,
0.020704983,
-0.022207871,
-0.005082315,
0.019457048,
-0.02989676,
-0.011405855,
0.010345782,
-0.012586697,
0.008245762,
0.029628387,
-0.015418033,
0.00966814,
0.008621485,
0.02978941,
-0.007454062,
-0.028367033,
0.0051091523,
0.018625092,
-0.0007325746,
-0.032553654,
0.0056794453,
-0.0014081199,
-0.0023751017,
-0.013834632,
-0.0036398098,
-0.02083917,
-0.014760519,
0.003975276,
-0.00353917,
-0.027347216,
0.023670506,
-0.0031785436,
0.017860228,
-0.0058538876,
-0.009728524,
0.0040826253,
-0.015042311,
-0.011587007,
0.0028531412,
-0.045140352,
0.0014290866,
0.015002055,
0.01284836,
0.00097201375,
-0.012070079,
-0.00013072704,
0.009144813,
0.00085166516,
0.012942292,
-0.015136241,
-0.00997006,
-0.024274344,
-0.006742873,
-0.022274965,
0.038806748,
-0.024099901,
-0.010426294,
0.012318324,
-0.0219395,
-0.013425363,
-0.012472639,
-0.013687027,
-0.005112507,
0.0011447789,
-0.021536939,
0.038028464,
0.03408338,
0.030836066,
0.019188674,
-0.0076150857,
-0.0015758531,
-0.027749775,
0.010439713,
-0.00033672433,
-0.02511972,
0.036445063,
0.017685786,
-0.015914524,
-0.024059646,
0.00090156577,
-0.010178049,
0.0005816148,
-0.010399456,
0.012586697,
-0.015216753,
0.00077115325,
0.004991739,
-0.0138748875,
-0.025321,
-0.031238625,
0.074876085,
-0.0010022057,
0.004226876,
-0.01643785,
0.000683932,
0.008057902,
0.009191778,
-0.016974596,
-0.02842071,
-0.0066019776,
-0.030916577,
0.017336901,
-0.012110335,
-0.013143571,
0.017712623,
0.008500717,
-0.021241728,
0.041785687,
-0.022650687,
-0.013009384,
-0.024421949,
-0.011768159,
0.0069508627,
0.0021218245,
-0.002801144,
-0.028044986,
-0.012868489,
-0.005253403,
-0.034539614,
0.0067294547,
-0.005763312,
0.0034922047,
0.008353112,
-0.008400077,
-0.020678146,
-0.008192088,
-0.0147471,
-0.0033731142,
0.024757415,
-0.009574209,
0.0002589381,
0.022838548,
0.009091138,
-0.006417471,
-0.014196935,
0.0294942,
0.020611051,
-0.012002986,
-0.00059629144,
-0.010406166,
-0.032312118,
0.005055478,
-0.007427225,
0.021053867,
-0.0119627295,
-0.013572969,
-0.012177428,
-0.01375412,
0.0059578824,
-0.005484875,
0.0098560015,
0.013794376,
0.0011892281,
0.00017119266,
-0.004075916,
-0.16950443,
0.0053875893,
0.017860228,
-0.028474383,
0.026381074,
0.0117413215,
0.010231723,
-0.018262787,
-0.0059243357,
0.014384797,
0.024502462,
-0.001824937,
-0.035022687,
-0.024234088,
0.03080923,
0.013955399,
-0.017994415,
0.0330904,
0.017108783,
0.013982237,
0.031131277,
-0.016800154,
0.009715105,
0.022382313,
-0.019953538,
0.029118478,
0.012707465,
-0.023683924,
-0.009386349,
-0.019457048,
-0.03507636,
0.0067864843,
0.019376535,
-0.007004537,
0.025777234,
-0.011888927,
-0.022865385,
-0.022972735,
-0.0063168313,
0.005095734,
0.03660609,
0.02073182,
0.015418033,
-0.007910296,
-0.011217995,
0.03947768,
0.010003606,
0.0042872597,
0.028125498,
-0.018517742,
0.02231522,
-0.011895636,
0.018088344,
0.027535077,
0.022060266,
0.010379328,
0.0008629872,
-0.003767287,
-0.021563776,
-0.024690323,
-0.012130463,
0.011566879,
0.026958074,
-0.008346402,
-0.021738218,
-0.026434748,
-0.01994012,
0.021375915,
-0.018316463,
0.0070716306,
-0.015807174,
-0.016021872,
0.028098661,
-0.022489663,
0.026354237,
0.00009849082,
-0.010734923,
-0.004656273,
0.019658327,
0.007722435,
-0.032473143,
0.020637888,
-0.040792707,
-0.017202714,
-0.01415668,
0.010312235,
0.020812333,
0.024609812,
0.001759521,
-0.0015565638,
0.015257009,
-0.012096916,
-0.0068837693,
-0.009708396,
0.023858367,
0.019966956,
-0.015310684,
-0.012942292,
-0.010345782,
0.0016781704,
0.016880667,
-0.009614466,
-0.0055351947,
0.0026384427,
0.036230363,
0.004156428,
-0.012170719,
0.011446112,
0.03547892,
0.008366531,
0.0027575332,
0.00393502,
-0.004696529,
0.016290246,
-0.013398525,
0.026273724,
0.004961547,
-0.0056324797,
-0.013526003,
-0.019483885,
0.07825759,
0.024663486,
0.016706225,
0.030057784,
0.015834011,
-0.043073878,
-0.13268365,
-0.019228932,
0.008091448,
0.0014341186,
-0.0013343174,
-0.0119627295,
0.0002719374,
0.0466164,
-0.0070917583,
0.04039015,
-0.025173394,
0.00286656,
-0.007856621,
-0.005900853,
0.008561101,
-0.014035911,
0.019121582,
-0.017658949,
-0.024609812,
0.041275777,
-0.021281984,
0.002527739,
0.028018149,
0.0071991077,
-0.0061054872,
-0.0017058463,
-0.026273724,
0.032526817,
0.007293038,
0.014532402,
0.011647391,
-0.009587628,
0.020248748,
0.011050262,
-0.027776614,
-0.01603529,
0.0065952684,
-0.020866007,
0.053755127,
0.008037774,
0.0076217954,
0.024314601,
0.023160595,
0.016021872,
0.011540042,
-0.01713562,
-0.0019943474,
0.015726661,
-0.0007883459,
-0.023737598,
-0.02432802,
-0.01863851,
-0.0330904,
-0.014505564,
0.0068904785,
-0.022798292,
0.0096882675,
0.022986153,
0.0020815686,
0.007937133,
0.010030444,
-0.0044315103,
-0.0053942986,
-0.006209482,
0.02023533,
-0.030272482,
-0.018517742,
-0.045059837,
0.012070079,
-0.014116423,
-0.0006289994,
-0.0023113631,
-0.0050118673,
-0.0054982933,
-0.01732348,
0.0146800075,
-0.019000813,
-0.007554702,
-0.00086550316,
-0.00024048744,
-0.006917316,
-0.021993173,
0.018705603,
-0.02034268,
0.029574713,
0.0017930676,
0.016115803,
0.001054203,
0.01685383,
0.009057591,
-0.010654411,
0.028152335,
-0.005364107,
-0.0092454525,
-0.022113942,
0.017122202,
0.013197246,
-0.011868799,
0.008795927,
0.027883962,
-0.025374673,
-0.010258561,
-0.04911227,
0.010184758,
0.012177428,
-0.003924956,
-0.005270176,
-0.011010005,
0.027333798,
-0.019470466,
0.0074003874,
0.011150901,
-0.0048609073,
-0.0062061273,
-0.013385107,
-0.01853116,
-0.014908124,
-0.012251231,
0.015431452,
-0.0113253435,
0.009755361,
0.028823268,
0.0051091523,
0.0094400225,
0.0026837308,
0.006169226,
-0.0028715918,
-0.022650687,
-0.02501237,
0.022677524,
-0.009399767,
0.020490283,
0.014894705,
-0.041919872,
0.0012621921,
-0.000353288,
0.0012496121,
-0.017887065,
0.0134522,
0.03268784,
0.011580298,
0.02501237,
-0.015820593,
-0.02729354,
0.010748342,
-0.025280744,
0.00328757,
0.0035760712,
-0.027360635,
-0.0022258193,
0.009520534,
-0.021818731,
0.03628404,
0.0030393251,
-0.0013921853,
-0.02133566,
-0.019457048,
-0.010211595,
-0.005390944,
-0.0052768853,
-0.017913902,
-0.025750397,
0.000110913556,
0.016317083,
0.011593717,
0.0036029085,
-0.009339383,
-0.015310684,
-0.057056114,
0.017095365,
-0.0003725773,
-0.043583788,
-0.022972735,
0.0059679463,
0.04036331,
-0.005052123,
0.009728524,
-0.0026267015,
-0.024985533,
-0.009272289,
-0.00083111785,
0.004146364,
0.020020632,
-0.006578495,
-0.0175516,
-0.003074549,
0.01983277,
-0.0024153576,
-0.0036599378,
0.009393058,
0.011110645,
-0.0070313746,
-0.007950552,
0.0056391894,
0.0113253435,
0.0055586775,
0.012982547,
0.015793756,
0.0014601173,
-0.010144502,
-0.002128534,
0.015230171,
0.0038779909,
-0.010902656,
-0.014438471,
-0.009091138,
0.0019121581,
0.017752878,
-0.02133566,
-0.028098661,
-0.0017712623,
0.009996897,
0.004642854,
0.0060786502,
-0.0044617024,
0.004028951,
-0.00643089,
0.03158751,
-0.0075010275,
0.00009246291,
0.004894454,
0.022006592,
0.018383555,
0.009547372,
-0.009299127,
-0.004545569,
0.0008621485,
0.0028246266,
0.03169486,
-0.024435367,
0.022529919,
-0.010573899,
0.019752258,
-0.010781888,
-0.027910799,
0.00343853,
-0.007004537,
-0.02163087,
0.0011909055,
0.031050764,
-0.015082567,
0.08104867,
0.01584743,
-0.010131083,
0.002921912,
-0.0027374052,
0.008084739,
-0.0060618767,
0.0058371145,
-0.039128795,
-0.041946713,
0.002083246,
-0.027749775,
0.022690943,
-0.045086674,
-0.018812953,
0.029064804,
-0.005082315,
0.0026065735,
-0.0020060886,
-0.033815008,
0.020463446,
0.00558216,
-0.006118906,
0.022945898,
-0.029386852,
-0.0008613098,
0.034351755,
0.014331122,
0.0061893538,
-0.029198991,
0.006048458,
-0.0018014542,
-0.021456428,
-0.0022191098,
0.0090240445,
-0.033305097,
0.008051192,
-0.0059545278,
0.0071320143,
0.011607136,
-0.005283595,
0.0033798234,
-0.011774869,
-0.026206631,
0.014478727,
0.0025931548,
0.0015448225,
-0.009077719,
-0.008037774
] |
OBJECTIVE We explored the subjective effects associated with olanzapine, risperidone and older antipsychotics. METHOD We conducted a content analysis of an Internet database of comments about prescribed medications. RESULTS We analysed 223 comments on risperidone, 170 on olanzapine and 46 relating to three older antipsychotics. The predominant subjective effects produced by all drugs consisted of sedation, cognitive impairment and emotional flattening or indifference. Connections appeared between these effects and Parkinsonian-like symptoms with the older drugs, sexual impairment with risperidone and metabolic effects with olanzapine. The experience of | [
0.0045233266,
-0.0033736068,
0.04202062,
-0.031035868,
-0.015005487,
0.024334643,
-0.006385873,
-0.02101031,
-0.02867073,
-0.026988855,
-0.021930085,
0.031535175,
0.0033161207,
0.00994672,
0.00056541583,
0.034163106,
0.052611183,
-0.008934966,
0.014151409,
0.0011743568,
-0.010472306,
0.008140017,
-0.020366468,
-0.013704661,
-0.022468813,
-0.0068260515,
0.008120308,
-0.023493705,
-0.021614734,
0.009217469,
0.0010404965,
0.0039583216,
0.004014165,
0.00011548526,
-0.0077326875,
-0.023625102,
-0.0103540495,
-0.015609912,
-0.008718162,
0.00029810594,
0.01952553,
-0.008297693,
-0.024374062,
-0.00592927,
0.007207101,
0.023230912,
-0.016739922,
-0.014269667,
-0.023165213,
0.007115124,
0.018671451,
0.0229944,
0.00877072,
0.007003437,
0.03056284,
-0.033821475,
0.02106287,
0.013573265,
0.00572232,
-0.016555967,
0.011129289,
0.010813937,
-0.011405221,
0.011543188,
-0.029695623,
0.01675306,
-0.0054792366,
-0.005433248,
0.01068254,
-0.02332289,
0.051954202,
0.02563547,
-0.02367766,
0.018408658,
0.01871087,
-0.0009247033,
-0.01337617,
0.01108987,
0.0144404825,
0.025924541,
0.021549037,
-0.0091452,
-0.010347479,
0.019748904,
0.012430115,
0.010643122,
-0.005124466,
0.04086433,
0.007818095,
0.0035838413,
-0.0051014717,
0.012075344,
0.020892054,
0.027987467,
-0.0038761985,
0.030746795,
-0.000420469,
0.015912123,
-0.03439962,
-0.006550119,
0.0041094273,
0.023651382,
-0.052322112,
-0.01451932,
0.0064877053,
0.0013303902,
-0.013573265,
0.005466097,
0.0056697614,
-0.0005325667,
0.011700864,
0.031903084,
-0.013507566,
-0.03471497,
-0.0081794355,
-0.016897598,
-0.012646919,
0.0029268584,
-0.0014502895,
-0.017738536,
0.0057880185,
0.020392746,
0.02827654,
-0.024347782,
0.0075881514,
-0.008514497,
-0.00592927,
-0.013928035,
-0.018579474,
0.008383101,
-0.0013500997,
0.0068523306,
0.011891389,
-0.025096742,
-0.017331207,
0.027672116,
-0.012686338,
-0.01681876,
-0.016332593,
-0.03313821,
0.01685818,
0.0074501853,
-0.023375448,
-0.005278857,
-0.012784885,
0.006753783,
0.02754072,
0.021824969,
0.002519529,
0.008849558,
0.009066363,
0.0025178867,
-0.02256079,
-0.0011768205,
-0.009861312,
0.011280395,
0.008501357,
0.008862698,
-0.021128567,
0.00034717435,
-0.001052815,
-0.022035204,
-0.009046653,
0.009026944,
0.011503769,
0.0009887591,
-0.00025150125,
-0.015386538,
-0.009243748,
-0.020970892,
0.0005925164,
0.040732935,
-0.034636132,
0.02638443,
0.014755834,
0.0056303428,
0.009986139,
0.019013083,
-0.016109219,
-0.022481952,
-0.024295224,
0.005998253,
0.022941839,
0.014282806,
-0.005272287,
-0.019289015,
0.021049729,
-0.0137572205,
-0.018448077,
-0.013146226,
0.008987525,
0.007377917,
-0.005876711,
-0.031850528,
-0.630283,
-0.019367853,
0.0031272382,
-0.024045572,
0.034110546,
0.025714308,
0.004322947,
0.0058799963,
-0.009802183,
0.028145144,
0.008711592,
0.008146587,
0.03818384,
-0.03169285,
-0.035240557,
0.0010758094,
0.001681876,
-0.009513111,
0.01566247,
-0.018868547,
-0.0070888447,
0.02943283,
-0.016201196,
-0.012344707,
0.021588456,
0.0026887022,
0.021378221,
-0.034741253,
-0.018369239,
0.04099573,
-0.0054825214,
0.014821532,
-0.008908687,
0.0067077945,
0.05397771,
-0.008468509,
0.0048649576,
0.016017241,
0.026581524,
0.037211508,
-0.009578809,
-0.0011324742,
0.022192879,
-0.013993734,
-0.023835337,
-0.0041849804,
0.018093307,
-0.002494892,
0.0011365802,
0.00515403,
0.0015225577,
0.011792841,
-0.0077721067,
0.0038072155,
0.03177169,
-0.009460553,
0.02864445,
0.005738745,
-0.0011201557,
0.010583993,
-0.007607861,
0.00800205,
-0.015833287,
-0.01068254,
-0.024374062,
0.03476753,
0.0055482197,
0.006231482,
0.004654723,
-0.01875029,
0.0053182757,
0.025530351,
-0.03014237,
-0.02257393,
0.008652464,
0.004102858,
0.020563561,
0.022652768,
-0.02442662,
0.0018674736,
-0.0028660875,
0.0014190829,
-0.05387259,
-0.0008306726,
0.029616784,
0.00014135396,
-0.00802176,
0.022232298,
0.005847147,
-0.009309446,
0.0034195955,
0.0028398081,
0.0034393051,
-0.025044184,
-0.023191493,
0.022797303,
-0.0028545903,
-0.0034852938,
-0.0062216274,
-0.010498585,
-0.02599024,
-0.004244109,
-0.004582455,
0.018526915,
0.008698452,
0.027750954,
-0.00018292865,
-0.007003437,
0.05169141,
-0.034741253,
0.008705022,
-0.0064252918,
-0.00015870242,
-0.01685818,
-0.00033465063,
-0.031140985,
0.023546264,
0.008061179,
-0.00497993,
-0.023993012,
0.020103674,
0.013198785,
-0.003058255,
0.021838108,
-0.0070888447,
0.002307652,
-0.001545552,
0.004086433,
-0.026174195,
-0.014585018,
0.015517934,
0.0015907197,
0.005429963,
0.004697427,
-0.006228197,
0.021824969,
0.013133086,
-0.0057781637,
0.019354714,
-0.028171422,
-0.034136828,
-0.00091649103,
-0.0047631254,
0.002429194,
-0.0074830344,
-0.038446635,
0.019039363,
0.0027593279,
-0.017370626,
0.0038400646,
0.010426317,
-0.013928035,
-0.0035772715,
0.02136508,
0.019512389,
-0.017699117,
0.011201557,
-0.005308421,
-0.019709485,
0.0038959081,
0.016608525,
0.023848476,
-0.008921826,
-0.004589025,
-0.027672116,
-0.056342844,
0.0023487136,
0.01526828,
0.007581582,
-0.026436988,
-0.005663192,
-0.012798025,
0.01187168,
-0.0011981725,
-0.015031767,
0.038105004,
0.008961245,
-0.018198423,
0.024649994,
0.0025950822,
0.0013698091,
0.031456336,
-0.020747516,
0.010984752,
0.022350555,
-0.002271518,
0.044385757,
0.037027553,
-0.011293534,
0.022219159,
0.0070494255,
0.034268223,
0.003968176,
0.006182208,
-0.022665907,
-0.00016640143,
0.023901034,
0.007115124,
0.00024903755,
0.01906564,
0.0342945,
0.0044543436,
0.011392082,
-0.010662831,
0.020432165,
-0.01453246,
0.01603038,
-0.0321396,
0.006615817,
0.025017906,
0.0010462451,
-0.0047269915,
-0.004700712,
-0.021903807,
-0.0028118864,
0.026594665,
0.004648153,
0.028723288,
-0.005771594,
-0.003306266,
-0.0009534463,
0.014716415,
0.01949925,
0.019249596,
0.008231995,
0.01831668,
0.037027553,
0.020800076,
0.020497864,
-0.01070882,
-0.0018067027,
0.025871983,
0.012193601,
0.0019479541,
0.006454856,
0.017370626,
0.016280035,
-0.003708668,
0.019157618,
0.0017311497,
-0.015623051,
0.051796526,
0.03397915,
-0.0074830344,
0.0031847241,
0.0046120193,
0.040601537,
0.021890666,
0.009631368,
0.021509618,
0.011503769,
-0.015807007,
-0.026910016,
-0.030773075,
-0.0047565554,
-0.0044050696,
-0.0059719738,
0.00764728,
0.009756194,
0.03786849,
0.019643785,
-0.026042799,
0.011779701,
0.003130523,
-0.013179075,
-0.0044871927,
-0.0045167566,
0.0008117844,
0.0105774235,
-0.008659033,
-0.014690136,
-0.009697067,
0.014768974,
-0.032717742,
0.013520706,
0.0065928223,
-0.018159004,
0.0046350136,
0.027225368,
0.025083603,
-0.0023552834,
-0.019197037,
0.022074623,
0.01646399,
0.012108193,
-0.0025540206,
-0.014309086,
-0.00025786576,
-0.0033226905,
0.022311136,
-0.013422159,
0.011510339,
0.026292453,
0.017883072,
0.0039583216,
0.00083970616,
0.049431387,
0.009007234,
0.012745466,
-0.01685818,
0.005275572,
0.0024554732,
0.008350251,
-0.015071185,
0.016385151,
0.013047678,
-0.0051474604,
-0.04054898,
-0.029248875,
0.010426317,
0.0015217364,
0.023953592,
-0.01800133,
0.005124466,
0.003672534,
0.0067077945,
-0.03555591,
0.013494427,
0.013573265,
-0.027619557,
-0.01643771,
-0.023874756,
0.00052024826,
0.014939789,
0.056763314,
0.010137245,
0.0037513718,
0.013152796,
0.015150024,
0.00649099,
-0.01301483,
-0.0153602585,
0.0052525774,
0.0137572205,
-0.0060935155,
-0.0000013425162,
0.022311136,
-0.007069135,
0.00879043,
-0.0033900314,
0.020195652,
-0.034820087,
0.019591227,
-0.037710812,
-0.001060206,
0.0125023825,
0.020970892,
0.053294446,
0.025149303,
-0.012679768,
0.03058912,
0.029012362,
0.023401728,
-0.014939789,
-0.02102345,
0.004060154,
-0.003324333,
0.042178296,
-0.032638907,
-0.020852635,
0.02139136,
0.014598158,
0.008751011,
0.00039583215,
0.0038761985,
-0.005847147,
0.014203968,
-0.025149303,
-0.0066256714,
0.008665604,
0.013172505,
0.011878249,
-0.014243388,
-0.012909712,
0.0025688028,
-0.018053887,
0.010209513,
-0.012660059,
0.015439096,
-0.003445875,
-0.013481287,
-0.020484723,
-0.008902117,
-0.01868459,
-0.0041751256,
-0.020011697,
0.023611963,
-0.023060096,
-0.008212285,
-0.023375448,
-0.0028036742,
-0.013481287,
-0.018080167,
0.017659698,
0.014729555,
-0.0020892054,
-0.021890666,
-0.006113225,
0.030457724,
0.028381657,
0.0018444792,
-0.0036265452,
0.030221209,
0.027908629,
-0.013323612,
-0.012259299,
0.025793144,
-0.015136884,
0.04312435,
-0.0014527532,
-0.027934909,
-0.01834296,
-0.0013960885,
0.012331568,
0.015623051,
-0.027356764,
0.0054398174,
-0.00093948544,
0.00800205,
0.0151237445,
0.015058046,
0.032638907,
0.0040634386,
-0.034583576,
-0.0018674736,
-0.021982646,
0.020511003,
-0.02256079,
0.0029564227,
-0.0020645685,
-0.028986081,
0.004782835,
-0.006576398,
-0.028802127,
-0.001107016,
-0.009013804,
-0.021246824,
-0.00085325644,
0.0063497387,
0.018645173,
-0.0037645116,
0.052742578,
-0.00095262507,
-0.008264843,
-0.018132726,
-0.009289737,
0.020143094,
0.021562176,
-0.029327713,
-0.016569106,
0.00032294812,
-0.0058964207,
-0.03127238,
0.000071960145,
0.0051835943,
0.041416198,
-0.013336751,
-0.030904472,
-0.008481648,
0.013317041,
-0.026121637,
-0.008133447,
0.0028200988,
-0.013533846,
-0.0057026106,
0.007154543,
-0.007877224,
0.0037415172,
0.03815756,
-0.03019493,
-0.0160041,
0.0060869455,
-0.012265869,
0.021995785,
0.006527124,
-0.007377917,
-0.018618893,
0.0075158835,
-0.006188778,
-0.029248875,
0.015885845,
-0.01605666,
0.02717281,
0.0032652046,
0.013441868,
0.0155836325,
-0.014453622,
0.030694237,
0.0030812493,
0.0036988133,
-0.006431862,
0.008974385,
-0.011438071,
0.04785463,
0.00401745,
-0.0009362005,
0.003022121,
-0.012049065,
0.03140378,
0.017094692,
0.0037185226,
-0.008849558,
-0.027120251,
-0.028986081,
-0.023060096,
0.009513111,
-0.0036002658,
-0.010281781,
-0.036107775,
0.011825691,
0.010459166,
0.030063534,
-0.0047467006,
-0.02560919,
0.003445875,
-0.024873368,
0.020721238,
0.0036035506,
-0.01800133,
-0.027304206,
-0.015018627,
-0.007903503,
-0.015754448,
-0.0031535174,
-0.023257192,
0.018618893,
-0.00016055017,
0.0022879427,
-0.020773796,
0.018763429,
-0.0077655367,
0.02563547,
-0.01913134,
-0.01567561,
-0.008501357,
-0.00612308,
-0.020143094,
-0.035371955,
-0.0065862527,
0.017699117,
-0.0015012057,
0.024505459,
-0.031140985,
-0.021969505,
0.003091104,
-0.013113377,
0.010583993,
0.005604063,
0.027225368,
0.0071939616,
-0.004290098,
-0.015373398,
0.002163116,
-0.0057880185,
0.0018904681,
0.031535175,
0.022087762,
-0.019551808,
0.0037283774,
-0.008507927,
0.0028628025,
-0.03132494,
-0.02524128,
0.00003941897,
0.017502023,
-0.002609864,
-0.008343682,
0.0029137188,
-0.015202582,
0.031088427,
-0.016280035,
-0.024019292,
0.01721295,
-0.0020530713,
-0.020458445,
0.013008259,
0.001099625,
-0.004897807,
-0.0060968003,
0.0006081197,
-0.014808392,
0.010078116,
-0.012903143,
0.02288928,
-0.0148872305,
0.029643064,
-0.017909352,
-0.009013804,
0.003744802,
0.028828405,
0.005834007,
0.010084686,
-0.03849919,
0.036607083,
0.008836418,
-0.013435299,
0.009342295,
-0.038078725,
0.008632754,
0.003941897,
-0.0032208583,
-0.028986081,
-0.0015430884,
0.013238204,
0.025031045,
0.010958473,
-0.0106891105,
-0.0015348761,
-0.024676275,
0.00035826094,
0.009138631,
-0.03821012,
-0.00070625654,
-0.021890666,
0.0037382322,
0.0028036742,
-0.0028430931,
0.01789621,
0.0061329347,
-0.0020152947,
0.040759213,
-0.00842252,
-0.02867073,
0.029170036,
0.01453246,
-0.009256888,
-0.033374727,
0.012568081,
-0.015885845,
-0.01723923,
-0.014585018,
-0.008494788,
-0.021102289,
-0.027908629,
-0.00072144927,
0.020143094,
0.027120251,
0.0035674167,
0.039235014,
0.016017241,
-0.0025359537,
-0.007745827,
-0.031193543,
-0.013106807,
-0.031850528,
0.015807007,
-0.0046941424,
-0.0009304519,
0.009736485,
-0.0382364,
0.048459053,
0.020471584,
-0.02486023,
-0.012863724,
-0.010209513,
0.009664217,
-0.03169285,
-0.018408658,
0.018671451,
-0.019039363,
0.0035772715,
0.043676216,
0.0017557866,
-0.018566335,
-0.035739865,
0.017396905,
0.025215,
0.0069311685,
0.0126075,
-0.024268946,
0.003981316,
-0.030851914,
-0.023559403,
-0.016529687,
-0.0062150573,
0.043702498,
0.033006817,
-0.003330903,
-0.018474357,
-0.024229527,
-0.03476753,
0.006385873,
-0.009125492,
0.010807367,
0.022258578,
0.010255502,
-0.004815684,
-0.013284192,
0.02136508,
-0.006760353,
-0.048590448,
-0.02178555,
-0.0024735404,
-0.034136828,
0.030326327,
-0.021076009,
-0.047933467,
0.00915834,
0.03324333,
-0.030825634,
-0.033059373,
0.015938403,
-0.0137572205,
-0.00916491,
-0.020353327,
-0.0066815154,
0.013179075,
-0.0067143645,
0.008652464,
-0.023730218,
-0.004776265,
0.015491654,
0.007916643,
-0.0050357734,
-0.009605088,
0.006152644,
-0.0042769583,
0.01145778,
-0.02903864,
-0.030326327,
0.0025326686,
-0.018159004,
0.0017229374,
-0.0031682996,
0.0137572205,
0.0018658312,
-0.030746795,
-0.0003714006,
0.006957448,
0.011983367,
0.023099516,
0.01643771,
0.013888616,
0.0015044906,
0.009453983,
0.004996354,
-0.004930656,
-0.016910737,
0.02136508,
-0.00012544266,
-0.010275211,
-0.018618893,
-0.011155568,
0.026620943,
0.010590563,
-0.0061296495,
-0.0198803,
-0.0006265974,
-0.0045298967,
-0.020839496,
0.014361644,
-0.02714653,
0.0023257192,
0.002623004,
-0.024111269,
0.0148872305,
-0.001146435,
-0.0058964207,
-0.035529632,
0.032954257,
0.15515307,
0.007568442,
0.005811013,
0.019354714,
-0.0011086585,
0.0034294503,
-0.00047959745,
-0.007936352,
-0.013034539,
0.028171422,
0.030667957,
-0.010629982,
-0.008133447,
0.0030139086,
-0.005423393,
-0.011510339,
0.006385873,
-0.0079560615,
0.0029958417,
-0.0077852462,
0.005571214,
-0.02446604,
0.011799411,
-0.009375145,
0.040102232,
0.01721295,
-0.0103540495,
-0.014348504,
0.028749568,
0.0028430931,
-0.016109219,
-0.020011697,
0.013993734,
0.013625824,
-0.008724731,
-0.02639757,
-0.018697731,
-0.011989936,
0.0030171936,
0.004313092,
0.003432735,
0.017344346,
-0.0033424,
-0.0024883223,
0.014164549,
0.016923876,
0.007686699,
-0.0122790085,
0.0028660875,
-0.004858388,
-0.014808392,
-0.001315608,
0.024610575,
0.008573625,
-0.008678743,
0.0155836325,
0.033190772,
0.023598822,
-0.012541802,
-0.0044740527,
0.0023487136,
-0.008514497,
-0.012259299,
-0.004470768,
-0.00800205,
0.01221988,
0.00801519,
0.004155416,
0.0011308317,
-0.0229287,
0.016897598,
0.0011817479,
-0.028302819,
-0.00296135,
-0.003587126,
-0.017423185,
0.0120424945,
0.030746795,
0.036239173,
0.027225368,
-0.01260093,
-0.008980955,
-0.035766143,
0.00954596,
-0.045305535,
-0.018513776,
0.036160335,
0.012114763,
-0.02827654,
0.0035247128,
-0.03177169,
-0.010971613,
-0.007003437,
-0.01529456,
0.027698396,
0.0038334946,
0.0029055064,
0.012331568,
-0.026910016,
-0.003820355,
-0.01529456,
0.06753783,
0.010110965,
0.0085276365,
-0.01986716,
-0.015202582,
0.005006209,
0.018934244,
-0.0155836325,
-0.025149303,
0.006031102,
-0.030326327,
0.009348866,
-0.022521371,
0.009467122,
0.014322225,
0.020511003,
-0.011700864,
0.01567561,
-0.016647944,
0.007804956,
-0.0075355927,
0.0007202174,
0.007351638,
0.011963657,
0.010255502,
-0.008652464,
-0.0024193393,
0.008994095,
-0.010255502,
0.024111269,
-0.006382588,
-0.009053223,
-0.00534784,
-0.015320839,
-0.0044477736,
0.0035641317,
0.02291556,
0.009618228,
-0.006185493,
0.009204329,
-0.004460913,
0.004076578,
-0.008369961,
-0.0054890914,
-0.0039254725,
-0.00016034486,
0.0007124157,
-0.016529687,
-0.014939789,
-0.01107673,
-0.014611297,
0.013468147,
-0.004595595,
0.014834672,
-0.00052353315,
-0.022718465,
-0.024163827,
-0.0103212,
0.023178354,
-0.0359501,
0.016122358,
0.017396905,
-0.0057518845,
-0.00092880946,
0.018369239,
-0.16377267,
0.021535896,
0.021549037,
-0.01913134,
0.026988855,
-0.0146638565,
0.03894594,
-0.010643122,
-0.012719187,
-0.011530048,
0.0048813825,
-0.002810244,
-0.018119587,
-0.03284914,
0.015136884,
-0.0005933376,
-0.023809057,
0.026542105,
0.029196316,
0.013809779,
0.04464855,
-0.016411431,
0.016240615,
-0.009637938,
0.013205354,
0.014795253,
-0.02443976,
0.016385151,
-0.0014470046,
-0.0004980751,
-0.0057157506,
-0.007207101,
0.04701369,
0.0067932024,
0.01528142,
0.004963505,
-0.0025031045,
-0.017659698,
-0.010538004,
0.021956366,
0.019578088,
0.02371708,
0.0034294503,
0.025753725,
0.012009646,
0.007916643,
0.02488651,
-0.018763429,
-0.00804804,
-0.025162442,
-0.030983308,
-0.014453622,
0.008606475,
-0.015386538,
0.004707282,
-0.008041469,
0.021470198,
0.01789621,
-0.004332802,
-0.012791456,
-0.022968119,
-0.03358496,
0.02260021,
0.0004722064,
0.013993734,
-0.0015356973,
-0.016358871,
-0.014585018,
0.0024850375,
0.007877224,
-0.03778965,
0.017002715,
-0.011050451,
0.012318428,
0.019302156,
0.036186613,
-0.017685978,
-0.016739922,
0.0127388965,
0.010196373,
0.0011907814,
-0.011779701,
-0.043439705,
-0.009611659,
-0.0155704925,
0.007351638,
0.0013993734,
0.027803512,
0.011865109,
0.0026032943,
0.0110241715,
-0.026962575,
-0.00054899126,
-0.0035707015,
-0.013980594,
0.012890003,
0.00725966,
0.01603038,
0.004904377,
-0.030484002,
0.017423185,
-0.012883433,
-0.0019019652,
-0.010583993,
0.011438071,
-0.015412817,
-0.02903864,
-0.0008934966,
0.015163164,
-0.017265508,
-0.008744441,
0.025149303,
0.0029564227,
0.01675306,
-0.019013083,
0.030300047,
-0.0031288806,
0.0032044337,
0.008888978,
-0.0065172696,
0.054082826,
-0.01797505,
-0.01646399,
0.01949925,
-0.019985417,
-0.02864445,
-0.12298718,
-0.041389916,
0.010492016,
-0.006044242,
-0.0036791037,
0.018789709,
0.02101031,
0.01831668,
-0.0126140695,
0.014046293,
-0.0035772715,
-0.025398955,
0.001653133,
-0.016122358,
0.01945983,
0.0075487327,
0.034898926,
-0.012476103,
-0.024939068,
0.049510226,
0.002619719,
0.011674585,
0.02103659,
0.006950878,
0.0032192157,
-0.0016178201,
-0.007351638,
0.022350555,
0.0034590145,
0.0067866324,
0.01567561,
0.0027001994,
0.0053445552,
0.013343321,
-0.023401728,
-0.011057021,
-0.023901034,
-0.026055938,
0.035529632,
-0.027961189,
0.022114042,
0.0074239057,
-0.013533846,
-0.0013952672,
0.0013164293,
0.0023421438,
-0.021154847,
-0.010406608,
0.014322225,
0.024295224,
-0.00515403,
-0.02634501,
-0.0078115254,
-0.01793563,
0.046067633,
0.011378942,
0.018566335,
-0.004782835,
-0.025333257,
-0.010544574,
-0.017725397,
-0.017318066,
-0.019972278,
0.013507566,
-0.008888978,
-0.0045594606,
-0.0006159214,
-0.024268946,
-0.017659698,
-0.030878192,
-0.026463268,
0.001645742,
-0.009007234,
-0.00047877623,
-0.02517558,
0.000113945454,
-0.010078116,
-0.026883736,
-0.005594209,
-0.012988551,
-0.016687363,
-0.0077721067,
0.041100845,
-0.0035838413,
0.017436324,
0.0057091806,
0.0118454,
0.0006709437,
-0.0321396,
-0.019420411,
-0.0244529,
0.0182904,
-0.006977157,
-0.020379607,
-0.004674433,
-0.006428577,
-0.017817374,
-0.034241945,
0.010268642,
0.01906564,
-0.028040025,
0.0012802952,
-0.027041413,
0.010813937,
0.016923876,
-0.018658312,
-0.010400038,
0.009821893,
0.009138631,
-0.013284192,
-0.0057157506,
-0.0072465204,
-0.032165878,
0.009716776,
-0.019564947,
-0.00043278743,
-0.031246101,
-0.038446635,
0.011181847,
0.01373094,
0.012180462,
0.011681154,
-0.02024821,
0.023782779,
0.0038532042,
0.01300169,
-0.02178555,
-0.00992701,
-0.02220602,
0.0066650906,
-0.021299383,
-0.0009780831,
-0.014834672,
-0.0072793695,
-0.0035345675,
-0.012364416,
-0.014768974,
-0.0052887117,
0.009749625,
0.036501966,
0.00016937839,
0.041731548,
-0.030037254,
-0.031167265,
0.0101175355,
-0.051323496,
-0.014466762,
-0.023007538,
-0.034583576,
0.010781088,
-0.0006220806,
0.035109162,
0.031482615,
0.011378942,
-0.008895547,
-0.021864388,
-0.018500635,
-0.005311706,
-0.00201201,
-0.012449824,
-0.013080528,
0.007929782,
0.031009588,
0.0028184562,
-0.018829128,
-0.013192215,
-0.0031781544,
-0.013008259,
-0.02371708,
-0.002281373,
0.014111991,
-0.0030056965,
-0.03705383,
0.00067833473,
0.01603038,
0.027304206,
0.033190772,
0.0041587013,
0.0015521218,
0.018868547,
-0.00008884666,
0.012988551,
0.015885845,
0.0137572205,
-0.031797968,
0.006566543,
-0.00067751354,
0.02027449,
-0.01986716,
0.020143094,
-0.011326384,
0.004845248,
0.013264483,
-0.003133808,
-0.020708099,
0.003863059,
0.015478515,
0.015071185,
0.009046653,
-0.009046653,
0.009729915,
0.0020317193,
0.0012844014,
0.012423545,
-0.0077392575,
-0.011543188,
-0.0084159495,
0.0041849804,
-0.041836664,
-0.037815932,
0.013284192,
0.018697731,
0.03127238,
0.005278857,
-0.0050029242,
0.0021516187,
-0.015728168,
-0.0024111269,
-0.015478515,
-0.00534127,
-0.003015551,
0.01719981,
-0.015373398,
0.013678382,
0.006300465,
0.018526915,
0.010984752,
-0.028171422,
0.03014237,
-0.031167265,
0.035661027,
-0.008632754,
0.013297332,
-0.028828405,
-0.008757581,
0.007890363,
-0.019630646,
-0.018080167,
-0.016358871,
0.008540777,
0.0064811353,
0.064068966,
0.01763342,
0.0005999074,
0.007147973,
-0.004102858,
0.015425957,
-0.0062446217,
0.0016087866,
-0.01948611,
-0.0053182757,
0.0042342544,
-0.015688749,
0.039497808,
-0.009854742,
-0.0065632584,
-0.0014018371,
0.006231482,
0.013441868,
-0.012522092,
-0.039629202,
0.021509618,
-0.0022879427,
0.012732327,
-0.0064877053,
-0.021995785,
-0.037999887,
0.02864445,
-0.02714653,
-0.02746188,
-0.0466195,
0.0023634958,
0.026371289,
-0.036501966,
-0.023362309,
0.013822918,
-0.014046293,
0.0070165764,
-0.025438374,
-0.020760657,
-0.012068775,
-0.01413827,
0.0103409095,
-0.017357485,
-0.015504794,
-0.0018411943,
-0.026791759,
0.013008259,
-0.015872704,
-0.046409264
] |
OBJECTIVE White matter hyperintensities (WMHs) are areas of increased signal on T2-weighted magnetic resonance imaging (MRI) scans that most commonly reflect small vessel cerebrovascular disease. Increased WMH volume is associated with risk and progression of Alzheimer's disease (AD). These observations are typically interpreted as evidence that vascular abnormalities play an additive, independent role contributing to symptom presentation, but not core features of AD. We examined the severity and distribution of WMH in presymptomatic PSEN1, PSEN2, and APP mutation carriers to determine the extent to which WMH manifest in individuals genetically determined to develop AD | [
-0.0099157635,
-0.0065173726,
0.02582257,
-0.0070112115,
-0.02812282,
0.020390343,
-0.012216012,
-0.002012718,
-0.02220975,
-0.017700221,
0.009402431,
0.021209076,
0.0019396169,
0.018298026,
0.0041618915,
-0.0027924634,
0.039533094,
-0.0017836677,
-0.005887078,
-0.025198774,
-0.036648035,
0.018051108,
-0.014594235,
-0.00986378,
0.0017576762,
0.03464669,
0.020533297,
-0.03311319,
-0.0034763652,
-0.03994896,
0.020039458,
-0.022092788,
-0.001328004,
-0.016465625,
0.00860969,
0.006166487,
0.011650696,
-0.013541579,
0.02153397,
-0.01853195,
-0.021728907,
0.0056206654,
0.0023668525,
-0.014646219,
-0.026082486,
0.00054135453,
-0.016088748,
0.0006558797,
-0.004366575,
0.050787423,
0.02040334,
0.010175678,
-0.003188834,
0.008635681,
-0.00097062066,
-0.005948808,
0.011046394,
0.04028685,
-0.016062757,
-0.038441453,
0.022976499,
-0.008499226,
-0.02058528,
0.004174887,
-0.009103528,
-0.018739883,
-0.010656522,
0.02968231,
0.019376675,
0.0029029273,
0.031995557,
0.008752643,
-0.009239984,
-0.011468756,
0.041092586,
-0.016660562,
-0.022365699,
-0.010273146,
0.013476601,
-0.01298926,
0.02674527,
-0.028954549,
0.0006286698,
0.02361329,
0.011098377,
0.026511345,
-0.017687226,
0.025250757,
0.0012419071,
0.0007829944,
0.0057798633,
-0.0014539004,
0.007030705,
-0.008284795,
0.013008754,
0.01209905,
0.019493636,
0.013281665,
0.0070112115,
-0.014802168,
-0.02469194,
0.013320652,
-0.054426234,
-0.011696182,
-0.013132214,
-0.018739883,
-0.015932798,
0.012001582,
0.013957444,
-0.02796687,
-0.014178372,
0.018713892,
0.000015508609,
-0.015724868,
-0.010916436,
0.0069982153,
0.008921588,
0.010247155,
0.011735169,
-0.020026462,
0.006816275,
0.00811585,
0.013801495,
-0.014100397,
0.0053412565,
0.025445694,
-0.02074123,
-0.008219817,
0.0024545738,
-0.022807555,
-0.011111373,
-0.0067123086,
0.012631876,
-0.023795232,
-0.015049088,
0.01090344,
-0.014009426,
-0.0061534913,
-0.017635243,
-0.037609722,
0.009954751,
0.02101414,
-0.025107805,
-0.012216012,
-0.021845868,
0.037323818,
0.03173564,
0.024276076,
0.007855936,
-0.0057051377,
-0.025952527,
-0.0098377885,
0.0060885125,
0.0056499057,
-0.015412969,
0.028096829,
0.009512895,
0.010747491,
-0.036726013,
-0.012813817,
-0.0123134805,
0.0061892294,
-0.010175678,
0.019181738,
0.0019786041,
0.013275166,
-0.026667295,
-0.011137364,
-0.003130353,
-0.01988351,
-0.025679618,
0.013223183,
-0.04304195,
0.014373308,
-0.0040936638,
-0.007128173,
0.02110511,
0.028148811,
-0.0382855,
-0.035296477,
0.00078624336,
-0.0013182572,
0.006283449,
-0.020169416,
0.000940568,
0.006751296,
0.049097974,
-0.030072182,
0.0017528029,
-0.033529054,
0.0019526125,
0.014477274,
-0.022014813,
-0.035712343,
-0.6416785,
-0.0101107,
-0.0013921706,
-0.013320652,
0.013593563,
0.02931843,
0.023145445,
0.003271682,
-0.015945794,
0.027395057,
-0.003596576,
0.02180688,
-0.025757592,
0.00014467933,
0.0036095716,
-0.02846071,
-0.019259714,
-0.020481315,
0.026004512,
0.0011281943,
-0.0018324018,
0.017141404,
-0.0012687108,
0.0010039223,
0.016244696,
-0.00040388378,
0.002493561,
0.00097630627,
-0.015477947,
0.03272332,
-0.02931843,
0.03295724,
-0.0025601643,
0.034230825,
0.053438555,
-0.0024058397,
-0.011748165,
0.03708989,
0.013788499,
0.023444347,
0.0071671605,
-0.007453067,
0.013736516,
-0.000029316601,
-0.004928641,
0.042652078,
-0.005958555,
0.0004613494,
0.01467221,
-0.028408727,
0.0053769946,
-0.010188674,
-0.016686553,
0.01844098,
0.011670191,
-0.021261059,
0.013320652,
-0.013736516,
0.0051885564,
0.014737189,
0.0023132449,
0.021572959,
-0.008999562,
0.003697293,
-0.0073555987,
0.007686991,
-0.017882163,
0.011533735,
0.01152074,
-0.0008390386,
0.0040416806,
0.020754226,
-0.0009600616,
0.017258367,
0.02916248,
0.017726213,
0.027395057,
0.000912952,
-0.010240657,
-0.01458124,
-0.0033659013,
0.0064588916,
-0.01543896,
-0.010130193,
0.021248063,
-0.008499226,
-0.023288397,
-0.0019493636,
-0.005796108,
0.009694835,
-0.00006249132,
-0.004873409,
0.0012232257,
-0.061859805,
-0.014048414,
0.013749512,
0.0038369976,
0.021845868,
0.008141842,
0.010325129,
-0.020013466,
0.0032278213,
-0.011345296,
0.014555248,
0.018908827,
0.009805299,
-0.038857315,
0.005909821,
0.04678473,
-0.021715911,
0.012164029,
0.011065887,
-0.00866817,
-0.007069692,
-0.0180771,
-0.021287052,
-0.0010680888,
-0.00264951,
-0.008083361,
-0.020650258,
0.04184634,
0.015893811,
-0.009363444,
-0.0054322267,
0.010299138,
-0.0079144165,
0.005136573,
-0.012748838,
-0.015049088,
-0.00013604933,
-0.0069007473,
-0.03087792,
0.01277483,
-0.0031563446,
0.017622247,
-0.013372635,
-0.0012134789,
-0.009298464,
-0.011514241,
-0.014724193,
-0.017024443,
-0.009110026,
0.01927271,
-0.015360986,
-0.0053899903,
-0.024367046,
-0.0008975195,
-0.007712982,
-0.014412295,
-0.017960137,
-0.0061210017,
-0.015309002,
-0.028720625,
0.009058043,
0.0015018223,
-0.0033594035,
0.01835001,
0.000032032513,
0.0032928002,
-0.026329406,
-0.013931452,
0.021468991,
0.00006315126,
0.020429332,
-0.016153727,
-0.03875335,
-0.0123134805,
0.01430833,
-0.011839136,
-0.021391017,
-0.009545384,
-0.004668726,
-0.011819642,
0.030332098,
0.0033626524,
0.04096263,
0.008440745,
-0.022664601,
-0.01620571,
-0.005321763,
-0.007680493,
-0.001773921,
-0.0038532421,
-0.011501245,
0.03290526,
-0.0070437007,
0.019766547,
-0.0021832874,
0.0035770824,
0.017635243,
0.014815164,
0.043977644,
-0.0058188504,
-0.003008518,
-0.015179045,
-0.008518719,
0.0000014927988,
-0.008765639,
0.0005876519,
0.02107912,
0.032099523,
0.0064004106,
0.030955894,
0.0020728235,
0.041820347,
-0.022261733,
-0.0044283043,
-0.025250757,
0.025835566,
0.0003531191,
-0.007069692,
-0.007459565,
0.0053867414,
-0.01647862,
-0.021170089,
-0.0056661502,
0.0025374216,
-0.0028931806,
-0.003382146,
-0.015373982,
0.0132946605,
-0.0031401,
0.021949835,
-0.006874756,
0.0067772875,
0.01467221,
0.038467444,
0.037115883,
0.0021394265,
-0.008356272,
0.0013076981,
0.029396404,
0.013346643,
0.018583933,
-0.0062054745,
-0.01047458,
0.0016301554,
0.003538095,
0.01586782,
0.00866817,
0.014425291,
0.01841499,
-0.016946469,
-0.014334321,
0.014542253,
-0.019597603,
0.031293783,
0.025627634,
-0.0106630195,
0.0072061475,
0.0014896387,
-0.013190694,
0.004122904,
0.004399064,
0.0015440584,
-0.016257692,
0.02471793,
-0.017973132,
0.024821898,
0.020039458,
0.05265881,
-0.005308767,
-0.0017560518,
-0.010682513,
-0.012937277,
-0.008434246,
0.020507306,
-0.006507626,
0.0020175914,
0.012722847,
-0.025848562,
-0.011598714,
-0.009551882,
-0.044445492,
0.0058708335,
0.0014043541,
0.02487388,
0.021754898,
0.024743922,
0.033165175,
-0.018583933,
-0.028538683,
0.015425964,
0.031579692,
-0.035582386,
-0.016465625,
-0.0030410073,
-0.009064541,
-0.010338125,
-0.0034601204,
0.006283449,
0.0063614235,
-0.019246718,
-0.010760487,
-0.006965726,
0.011780654,
0.02778493,
0.02864265,
0.018064104,
-0.0054679653,
-0.01948064,
0.008960575,
-0.010948926,
-0.01816807,
0.00952589,
0.014464279,
-0.02291152,
0.011325803,
0.0020452074,
0.02058528,
-0.006260706,
-0.029214464,
-0.0005385117,
0.026641304,
0.00097062066,
0.009408928,
0.0040449295,
-0.003222948,
0.032801293,
0.019792538,
0.007407582,
-0.04506929,
-0.004561511,
-0.010370615,
0.038805332,
0.027005184,
-0.0032115767,
0.008557706,
0.0087006595,
-0.00013980592,
-0.020325365,
-0.018479967,
0.033581037,
0.0020240892,
0.0069592283,
-0.004866911,
0.028330753,
0.0032863023,
0.0076674973,
0.018830853,
0.009753316,
-0.031683657,
-0.000885336,
0.0006217658,
0.00011208841,
-0.018492963,
0.01948064,
0.03734981,
0.019337688,
-0.007303616,
0.00912952,
0.022222746,
0.021559961,
-0.0272651,
-0.019129755,
0.014685206,
-0.020650258,
0.016504612,
0.009408928,
-0.013197192,
0.00606577,
0.020234395,
0.0033529054,
-0.02386021,
0.0131776985,
0.014516261,
0.01620571,
-0.000052795265,
0.0033951418,
0.0051268265,
0.022235742,
0.022469666,
-0.0015546175,
-0.02180688,
0.017986128,
-0.009272473,
-0.0074140797,
-0.027473032,
0.03412686,
-0.008154838,
-0.0009673717,
-0.0018535199,
0.013502592,
-0.025315735,
-0.013905461,
0.00450303,
0.000017412285,
-0.019181738,
-0.014386304,
-0.0081873275,
-0.032125514,
-0.014334321,
-0.0017414315,
0.00082604284,
-0.004366575,
0.010221164,
-0.041794356,
0.0013239428,
0.022365699,
0.018064104,
0.013892465,
-0.025432698,
-0.010981415,
0.032645345,
-0.0055069523,
-0.0065206215,
-0.0005710011,
-0.0012289113,
0.0033139181,
0.0010542808,
-0.014568244,
-0.021209076,
-0.014932126,
0.0014539004,
-0.001531875,
-0.017713217,
0.036674026,
0.010591542,
0.0017934146,
-0.0006055211,
0.012794323,
0.014321325,
-0.0162317,
-0.017037438,
0.0033057958,
-0.028356744,
0.0037915122,
-0.039870985,
0.024977846,
-0.02094916,
-0.0073750927,
-0.009928759,
0.0036810483,
-0.008642179,
-0.024250085,
0.0029841508,
0.022534644,
0.0054029864,
0.014646219,
0.027862905,
0.014698202,
0.017960137,
0.013970439,
0.0010794601,
0.0055881757,
-0.01283331,
0.02399017,
-0.028954549,
-0.046680763,
0.016907481,
0.0067837853,
0.0063581746,
-0.023730254,
-0.009941755,
0.0027989612,
0.022651605,
0.0028265773,
-0.009928759,
-0.023132449,
-0.0103121335,
0.0022937513,
-0.002677126,
-0.018064104,
0.020637263,
0.010883947,
0.013398626,
-0.018401993,
-0.006848764,
0.03602424,
-0.037297826,
-0.0104290955,
0.011676689,
-0.0013743014,
0.020013466,
0.0060917614,
0.004340583,
-0.032359436,
-0.009116524,
-0.008466736,
-0.033295132,
0.00021686671,
0.013093226,
0.023808228,
-0.0018957561,
0.026849234,
0.010857956,
0.021637937,
0.025263753,
0.0028834338,
0.00836277,
0.014217359,
0.00017371673,
-0.022417681,
0.0152180325,
0.013489597,
-0.0038987272,
0.027057167,
0.0067772875,
0.027940879,
0.026602317,
-0.0031417245,
-0.0065531107,
-0.0037297825,
-0.05520598,
-0.018103091,
0.0030864924,
-0.008655175,
-0.0017657985,
-0.043951653,
0.0013320652,
0.02968231,
0.025900545,
0.014048414,
-0.01109188,
0.013073732,
-0.011098377,
0.017518282,
0.016998451,
0.013002256,
-0.007128173,
-0.021585954,
0.006108006,
-0.009149013,
0.03176163,
0.01139728,
-0.009123022,
0.022313716,
-0.0043698237,
0.007245135,
-0.001881136,
-0.050709445,
0.0050715944,
-0.024419028,
-0.026095482,
-0.02487388,
-0.024821898,
-0.029630328,
-0.017414315,
0.025588647,
0.021404013,
-0.020507306,
0.013502592,
-0.014334321,
-0.02760299,
0.018207056,
-0.015841829,
0.008297792,
-0.0134506095,
0.041768365,
0.025471685,
-0.012807319,
-0.032333445,
0.0036323143,
-0.002490312,
0.015179045,
0.02557565,
-0.003651808,
-0.027187126,
-0.0023181182,
-0.0077974545,
0.0014254722,
-0.02444502,
-0.038025588,
0.025198774,
-0.0148281595,
-0.0017008198,
-0.00091457646,
-0.0028996784,
-0.037791662,
0.036492087,
-0.027525015,
-0.012086054,
0.019987475,
-0.032671336,
-0.0020858191,
0.033399098,
-0.018544946,
0.021040132,
-0.01706343,
-0.030410074,
-0.016296681,
-0.006224968,
-0.028278768,
0.016803514,
-0.0020630765,
0.025094809,
-0.037661705,
-0.0011947975,
0.027239108,
0.01200808,
-0.004506279,
-0.004347081,
-0.016842501,
0.030046191,
-0.0034763652,
-0.005474463,
0.037297826,
-0.008622685,
-0.023353377,
0.0014043541,
0.0015156303,
-0.033814963,
-0.002662506,
-0.0063971616,
0.032801293,
0.034516733,
-0.0045290217,
0.015140058,
-0.033061206,
0.01825904,
-0.022521649,
-0.014893139,
0.011982089,
-0.040546764,
-0.037453774,
0.020572284,
-0.016803514,
0.038129553,
0.01636166,
-0.013034745,
0.0052795266,
0.03274931,
-0.016400646,
0.014126388,
0.01424335,
0.0068292706,
-0.0051300754,
0.0023002492,
-0.008980068,
-0.032645345,
0.0018990051,
-0.005357501,
-0.058740824,
0.0074920543,
0.0045712576,
0.024068143,
-0.007082688,
-0.0077584675,
0.01586782,
0.017362332,
-0.0050748433,
0.012995758,
-0.009356946,
0.012209514,
-0.02218376,
0.013697528,
-0.0009088908,
-0.017505286,
-0.006000791,
0.01828503,
-0.005640159,
0.014815164,
-0.02300249,
-0.015283011,
-0.016218705,
0.032879267,
-0.012495421,
0.004954633,
-0.004399064,
-0.027576998,
-0.022859538,
0.0011899241,
0.017037438,
-0.013041243,
-0.009019055,
0.009954751,
-0.01338563,
-0.0010762112,
-0.036726013,
-0.013554575,
0.00043413954,
-0.025861558,
-0.031995557,
-0.006059272,
-0.01620571,
0.039325163,
0.037921622,
0.0009064541,
0.0088566085,
0.000224786,
-0.04460144,
-0.017037438,
-0.0035770824,
-0.009902767,
0.024678944,
0.015503939,
0.0062444615,
0.016582588,
0.024704935,
-0.0015213159,
-0.0010672766,
-0.006764292,
0.0038499932,
-0.012105549,
0.008928086,
0.01188462,
-0.027836913,
-0.013015252,
0.025367718,
-0.011319305,
-0.02677126,
0.03563437,
-0.0028103327,
0.002168667,
-0.017349336,
0.010156184,
-0.0036355632,
-0.019831527,
0.003749276,
-0.015386977,
0.0071021817,
-0.011299811,
0.0033155426,
0.0149451215,
0.007277624,
0.013502592,
0.0149841085,
-0.017323345,
-0.021819877,
0.00038946662,
0.02916248,
-0.0061892294,
0.009259477,
0.01050707,
-0.017362332,
0.017388323,
0.012670863,
0.018401993,
-0.0015936048,
-0.0046589794,
0.0045777555,
-0.0047921855,
-0.0051853075,
-0.03789563,
-0.017778197,
-0.00074725604,
0.022677597,
-0.028174803,
-0.0022238991,
-0.005152818,
-0.01647862,
-0.028902564,
0.023171436,
-0.018544946,
-0.020962156,
-0.009629857,
-0.013645546,
-0.008642179,
-0.008583698,
0.0032944246,
0.00903855,
0.0014441536,
0.0012882045,
0.019428657,
-0.012995758,
0.0041976296,
-0.006111255,
-0.010494075,
-0.013132214,
0.007771463,
0.17466298,
0.014516261,
-0.0060950103,
0.0036063227,
-0.01467221,
0.0014067908,
0.03657006,
0.009123022,
0.014295333,
0.022092788,
0.02101414,
0.014633223,
-0.03724584,
0.014113393,
0.017414315,
-0.023561308,
-0.02916248,
-0.025692614,
-0.017596256,
-0.017453302,
0.00042967225,
-0.009486903,
-0.009226988,
-0.0088176215,
0.0071736583,
-0.015789846,
0.0018275285,
-0.014841155,
0.0401309,
0.012417447,
-0.016179718,
0.0013166327,
-0.007998889,
-0.006874756,
0.0035218503,
-0.022274729,
-0.0156209,
0.008492728,
-0.0006936486,
0.0026543834,
-0.006978722,
0.011657194,
-0.031423744,
0.02931843,
0.007985893,
0.018752879,
0.006062521,
-0.009239984,
0.003326914,
-0.00017463049,
-0.024315063,
-0.004434802,
0.015633896,
0.029006531,
0.00024103069,
0.002227148,
0.0020939414,
0.031475727,
-0.01927271,
0.011507743,
-0.019844523,
-0.018713892,
-0.020962156,
0.035478417,
-0.015607905,
0.032099523,
-0.0074335732,
-0.01157922,
-0.019922497,
0.016621575,
0.028564675,
-0.010760487,
-0.0078754295,
0.0024561982,
-0.010695509,
-0.0066798194,
0.04267807,
0.008707157,
-0.01767423,
0.013827486,
-0.005630412,
-0.009948253,
-0.0068422663,
0.002953286,
-0.017817184,
-0.034230825,
0.009610363,
0.017752204,
0.027473032,
-0.018453976,
-0.014139384,
0.007336105,
-0.006377668,
0.006809777,
-0.002438329,
-0.0023749748,
-0.0104680825,
-0.029812269,
-0.013086728,
0.0023441098,
-0.025393711,
0.06581052,
-0.0038207527,
-0.005139822,
0.007570029,
-0.005357501,
-0.002628392,
0.016049761,
0.0037070399,
-0.011267322,
-0.015309002,
-0.043665744,
-0.00033707748,
-0.0021897852,
-0.009077537,
0.025159787,
-0.0002700681,
-0.011897616,
-0.001331253,
0.016244696,
0.007336105,
-0.031371757,
0.010890445,
0.010981415,
-0.02049431,
-0.0035283482,
-0.01602377,
0.014594235,
-0.015815837,
-0.036933944,
0.0030491296,
0.00070501986,
0.0041651404,
0.02058528,
0.015932798,
-0.019844523,
0.0052470374,
0.0075180456,
-0.016920477,
0.021624941,
-0.01758326,
-0.015555922,
0.00029281067,
0.009356946,
0.021845868,
-0.005571931,
-0.0037297825,
0.0024090887,
-0.008655175,
-0.021858864,
-0.022716584,
-0.007453067,
0.004067672,
-0.0220538,
0.020637263,
-0.011358292,
-0.008564204,
-0.034074876,
-0.01338563,
-0.0006973036,
-0.03207353,
0.02677126,
0.006322436,
-0.0011476879,
0.0043178406,
0.0057181334,
-0.16218705,
0.016296681,
0.0059650526,
-0.016920477,
0.01954562,
-0.0045972494,
-0.0049481345,
-0.008161336,
-0.0049058986,
0.02040334,
0.0068032793,
-0.03602424,
-0.008050872,
0.0024464515,
0.00974032,
0.00069121184,
0.0047596963,
0.034698673,
-0.0024107131,
0.010617534,
0.0032911757,
-0.007654501,
0.029292438,
-0.009252979,
0.008271799,
-0.010740994,
-0.011286816,
0.038207527,
0.0030263872,
-0.0036745504,
0.0032456904,
-0.026485354,
0.037427783,
0.021858864,
0.001224038,
-0.0026365144,
-0.032203488,
-0.03945512,
0.0032278213,
0.015932798,
0.025406707,
0.0077909566,
0.016621575,
0.00578961,
-0.0079534035,
0.035296477,
0.0037232847,
-0.034516733,
-0.00578961,
-0.0038304995,
0.002324616,
-0.018674904,
0.0046004984,
0.0104161,
0.009668844,
0.0027437294,
-0.014035419,
0.0065693557,
0.019961484,
-0.029604336,
-0.016140731,
-0.004834422,
0.018220052,
0.00036408426,
0.015685879,
-0.019064777,
-0.0009162009,
-0.030280115,
-0.00986378,
-0.004126153,
-0.018116087,
-0.05141122,
0.0019509881,
-0.030046191,
0.029448386,
0.022924516,
-0.008824119,
0.004720709,
-0.014256346,
0.008135344,
-0.017180393,
0.019506631,
-0.01835001,
-0.01914275,
-0.0037232847,
-0.0027096155,
0.0031173574,
0.0048149284,
0.011670191,
-0.009376439,
-0.0133336475,
-0.016400646,
0.018337013,
-0.025315735,
0.016036766,
0.017869167,
-0.0039831996,
0.019740555,
0.008135344,
-0.00998724,
0.013710524,
0.012826812,
-0.016621575,
-0.018116087,
0.028590666,
0.009506397,
-0.013840482,
0.016413642,
0.02579658,
0.0019379924,
0.0011753038,
0.001293078,
0.012216012,
0.022807555,
0.02254764,
0.0076350076,
0.0070566963,
-0.004392566,
0.009181503,
-0.012378459,
0.055777792,
-0.00043941906,
-0.012690357,
0.0061794827,
0.0039961953,
-0.0070501985,
-0.120808564,
-0.022339707,
-0.034230825,
0.014113393,
-0.0008203572,
0.011280318,
-0.00027250478,
0.019155746,
-0.014750185,
0.027447041,
-0.01706343,
-0.019857518,
-0.00860969,
-0.0009689962,
0.019415662,
-0.02101414,
0.008824119,
0.008720153,
-0.035608377,
0.036128208,
-0.018947816,
-0.012859303,
-0.011748165,
-0.025406707,
0.002836324,
-0.015984781,
-0.018220052,
0.022378694,
-0.008375766,
-0.0015505564,
-0.0006010538,
0.0071606627,
-0.0028233284,
0.009668844,
-0.0020549542,
-0.011429769,
0.020624267,
-0.016556595,
0.025224766,
0.0032050787,
0.012261498,
0.03139775,
0.03121581,
0.016946469,
0.0036128205,
-0.0019314945,
-0.03537445,
-0.010117197,
0.0014270967,
-0.004217123,
-0.016907481,
0.0018518955,
-0.0115662245,
0.007946906,
0.010929432,
-0.012963268,
0.022924516,
0.013268668,
-0.019961484,
0.0075895223,
-0.0024399536,
0.008427748,
-0.043145917,
0.02564063,
0.02013043,
-0.009110026,
-0.02000047,
-0.035062555,
-0.010091206,
-0.030799946,
-0.010773483,
-0.004178136,
-0.015192041,
-0.012696856,
-0.015711872,
0.027525015,
-0.009948253,
-0.0061275,
0.008096357,
-0.0048084306,
-0.028330753,
-0.019558616,
0.013827486,
-0.020650258,
0.0043795705,
0.009694835,
-0.007063194,
-0.004834422,
0.018973807,
-0.019194733,
0.011013905,
0.04150845,
0.020455323,
-0.012261498,
0.0049123964,
0.014425291,
-0.0072061475,
-0.016803514,
0.037011918,
0.015451956,
-0.027213117,
-0.0077324756,
-0.04145647,
0.022508653,
0.0043828194,
0.0049156453,
-0.0074335732,
-0.011631203,
-0.0024886876,
-0.00020732294,
0.0012922656,
0.009584371,
-0.0063354317,
0.02934442,
-0.0016106617,
0.0011956097,
-0.024328059,
-0.008739647,
0.024743922,
0.016647566,
0.026485354,
0.02119608,
0.004714211,
0.014295333,
-0.0014092275,
0.018882835,
0.00024752857,
-0.009298464,
-0.028096829,
0.029474378,
-0.008765639,
0.017609252,
0.025562655,
-0.025484681,
-0.007407582,
0.012852805,
-0.0004087572,
-0.009655848,
-0.009298464,
0.013229681,
0.010351121,
0.018518955,
-0.021585954,
-0.027135141,
0.0031352264,
0.010565551,
-0.008902094,
0.006933237,
-0.020871187,
0.015737863,
0.0063971616,
-0.015945794,
0.026693286,
0.015815837,
0.0094479155,
-0.04629089,
-0.043795705,
0.033035215,
-0.004454296,
0.000037515096,
0.02606949,
-0.004665477,
0.009213992,
0.0066668238,
-0.004395815,
0.013437614,
0.013268668,
-0.009688337,
0.0038987272,
0.012027574,
0.0052860244,
-0.019623594,
-0.014269342,
-0.020143425,
0.024561983,
0.0035218503,
0.0081483405,
0.00054500956,
-0.003642061,
-0.004675224,
-0.016101744,
0.007303616,
0.0073620966,
0.011475254,
-0.03467268,
0.028408727,
0.023626288,
-0.020936165,
-0.0071151773,
0.01721938,
0.0035543398,
0.0025536665,
0.021417009,
0.02180688,
0.017596256,
-0.0044737896,
0.0064264024,
0.0025845312,
0.0042658574,
0.00986378,
0.024341054,
0.029292438,
-0.0016699549,
0.0072971177,
-0.0038759848,
-0.007907919,
-0.019623594,
0.013723521,
-0.03035809,
-0.011000909,
0.0026738772,
0.00080086355,
0.03825951,
0.005571931,
-0.013554575,
-0.001456337,
-0.015399973,
0.015893811,
0.008089859,
0.012482425,
-0.013593563,
0.0235873,
0.010825466,
0.0057473737,
0.0087786345,
0.01406141,
0.0012808944,
0.015179045,
0.023210423,
-0.03412686,
0.009265975,
-0.004555013,
0.011624705,
-0.027031176,
-0.024146117,
0.020182412,
-0.009512895,
-0.015425964,
0.0046849707,
0.031345766,
0.008440745,
0.08072965,
0.009623359,
-0.0063614235,
-0.003814255,
-0.015555922,
-0.0029402901,
0.010715002,
0.0033983907,
0.00551345,
-0.016036766,
-0.006855262,
-0.01835001,
0.035790317,
-0.014516261,
-0.05369847,
0.0031352264,
-0.017401319,
0.027421048,
0.0075765266,
-0.03139775,
0.007498552,
-0.001618784,
0.020052454,
-0.0041618915,
-0.01289829,
-0.029370412,
0.026901219,
-0.020845195,
-0.014685206,
-0.0003340316,
0.007946906,
0.016842501,
-0.02444502,
-0.022690592,
0.001542434,
-0.049513835,
-0.00096980843,
-0.020078445,
0.0018583933,
0.0024740673,
-0.0022109032,
0.033061206,
0.0047272067,
-0.008518719,
-0.0017138155,
-0.024432024,
-0.027031176,
-0.012839809,
0.0077584675
] |
In this paper we review the associations between maternal and child undernutrition with human capital and risk of adult diseases in low-income and middle-income countries. We analysed data from five long-standing prospective cohort studies from Brazil, Guatemala, India, the Philippines, and South Africa and noted that indices of maternal and child undernutrition (maternal height, birthweight, intrauterine growth restriction, and weight, height, and body-mass index at 2 years according to the new WHO growth standards) were related to adult outcomes (height, schooling, income or assets, offspring birthweight, body-mass index, glucose concentrations, blood pressure). We | [
0.008897232,
-0.012874125,
0.00065066747,
-0.0465434,
-0.0010335335,
0.0015175416,
-0.011727574,
-0.0044846507,
-0.02864411,
-0.024110321,
0.024411699,
0.009585163,
0.0019311188,
0.008589301,
-0.019209636,
0.0054477532,
0.042848233,
-0.026115146,
-0.005195512,
-0.027202731,
-0.03097652,
0.013889641,
-0.004749995,
-0.015815847,
-0.016549638,
0.01548826,
0.019851703,
-0.03708272,
0.0026796525,
-0.014125503,
-0.001991722,
-0.016313776,
-0.006145511,
-0.017558603,
-0.021450322,
-0.0034232724,
-0.006964476,
-0.009572059,
0.003780341,
-0.012277919,
0.0006326502,
0.008530336,
0.0020113774,
0.018174464,
-0.001553576,
0.0067351656,
0.012074815,
0.0066270623,
-0.014780675,
0.020231703,
0.005264305,
0.03139583,
-0.01903929,
0.012363091,
-0.01499033,
0.015920673,
-0.023009632,
0.020624807,
0.010764472,
-0.009991369,
-0.002293101,
0.0077768886,
-0.032444105,
0.013981365,
-0.018528257,
-0.01155723,
-0.0038622376,
0.019602738,
-0.00096146454,
0.009067577,
0.030242728,
0.027779281,
-0.016182743,
-0.00919206,
0.0073641306,
-0.0018115499,
-0.027071696,
-0.0072068893,
-0.0006678657,
0.0035772377,
0.009742404,
-0.00084762846,
-0.0026387041,
0.015959984,
-0.010698955,
-0.016536536,
0.0108955065,
0.017912395,
0.018646188,
-0.03265376,
0.0025371525,
-0.0025387905,
0.020349635,
0.010187921,
-0.0053887875,
0.011354126,
-0.0031890485,
0.033099275,
0.008169992,
-0.008707233,
-0.027884109,
0.022419978,
-0.0082879225,
-0.011065851,
-0.00021948254,
-0.00040845864,
-0.02357308,
-0.0015855157,
0.013044469,
-0.029744796,
-0.022118598,
-0.00007903009,
-0.011472058,
-0.03933651,
0.0018901705,
-0.007462406,
-0.0007464863,
0.010823437,
0.025735145,
-0.007534475,
0.017021362,
0.01949791,
0.029823419,
-0.0010302576,
-0.0089627495,
0.010731713,
-0.025853077,
-0.014295847,
-0.024503423,
-0.019615842,
-0.008648267,
0.00816344,
0.014335158,
0.0023815492,
-0.036139272,
0.027779281,
-0.017178603,
-0.03097652,
-0.02864411,
-0.03265376,
0.0033544793,
0.01670688,
-0.010902057,
-0.0054805116,
-0.0019868084,
0.032103416,
0.022799976,
0.012232057,
-0.005257753,
-0.00417672,
-0.013719296,
-0.012657918,
0.016497225,
-0.011976539,
0.010391024,
0.032915827,
0.023337217,
0.015462053,
-0.017113086,
-0.020022048,
-0.010843093,
-0.015003433,
-0.019917222,
0.008949646,
-0.015239295,
0.013188607,
-0.011347575,
-0.025499284,
0.02666549,
0.0010253438,
0.0054346495,
0.032942034,
-0.021450322,
0.0008672836,
-0.012087919,
0.0079472335,
0.0101093,
0.034488242,
-0.029744796,
-0.0037148239,
-0.0097817145,
0.024136527,
0.025158595,
0.008805509,
-0.026010318,
0.010600679,
0.016733086,
0.013509641,
0.013562055,
-0.011334471,
0.0021424117,
0.021673081,
-0.026888248,
-0.019786187,
-0.65202695,
0.0019311188,
0.00514965,
0.012919987,
-0.0042618923,
0.0027795662,
0.0066860276,
0.0020572392,
0.007698268,
0.03207721,
-0.021240668,
0.028329626,
-0.015199984,
-0.017755155,
-0.00025121743,
-0.015959984,
-0.040908925,
-0.021791013,
0.017650327,
-0.016287569,
-0.015763432,
0.019235842,
0.010659644,
0.011871712,
-0.009958611,
0.0052053398,
0.030766865,
-0.00839275,
0.010849644,
0.021266876,
0.006794131,
0.022341356,
0.012022401,
0.013719296,
0.041302025,
-0.033859275,
-0.011852057,
0.027648248,
-0.0045534438,
0.004019479,
-0.038130995,
-0.018371016,
0.015514467,
-0.0029892211,
0.0070168893,
0.027333764,
0.007141372,
0.012389298,
0.032811,
-0.02357308,
-0.0025666354,
0.016195845,
-0.009821025,
-0.014204123,
0.019904118,
-0.0044453405,
0.023717217,
-0.025211008,
0.007075855,
0.0065025794,
0.002086722,
-0.006846545,
-0.024319975,
0.0024732733,
-0.015239295,
0.027569627,
-0.017755155,
0.040489614,
-0.010155162,
-0.003475686,
0.000019514393,
0.046753056,
0.003223445,
0.011531022,
0.011858609,
0.018017223,
0.015199984,
0.011380333,
-0.020965496,
0.0045141336,
-0.010888955,
-0.0019556878,
-0.009873439,
0.0005401072,
0.0066532693,
-0.026862042,
-0.020703427,
-0.0027697387,
-0.016615156,
-0.0065746484,
0.007521372,
-0.00064370624,
-0.007907923,
-0.035903413,
-0.0065910276,
0.013234469,
-0.03758065,
0.018751016,
0.02010067,
0.0060144765,
-0.031841345,
0.0080913715,
-0.028984798,
0.002576463,
0.01720481,
0.025918594,
-0.01144585,
0.03341376,
0.035850998,
-0.03364962,
-0.014584123,
0.021869633,
-0.015344122,
0.012867573,
0.020965496,
-0.018580671,
0.010207576,
-0.013719296,
-0.015658604,
0.014308951,
0.018279292,
0.011642402,
0.018986877,
0.004157065,
0.0005962063,
0.007121717,
0.0037443065,
0.00858275,
-0.009237922,
-0.022524804,
-0.0064796484,
0.010220679,
0.021646874,
-0.01586826,
0.04780133,
0.010921713,
0.004523961,
-0.018986877,
0.010659644,
-0.010829989,
-0.012677574,
-0.011078955,
0.010902057,
-0.042166855,
0.007442751,
-0.023559976,
0.018135155,
-0.0006187278,
-0.007403441,
0.011013437,
-0.021319289,
-0.0067351656,
-0.011092057,
0.0012554729,
-0.010849644,
-0.020651013,
0.005519822,
-0.023062045,
-0.0048351674,
-0.012343436,
-0.0074558547,
0.027988937,
-0.024935836,
-0.004068617,
0.000077852834,
-0.010659644,
-0.017755155,
0.016719984,
0.009087232,
-0.013915848,
0.0028581868,
-0.03784272,
-0.0028614625,
0.017755155,
0.012323781,
0.017637223,
0.002943359,
0.01854136,
-0.02303584,
-0.0021456876,
0.006846545,
-0.03233928,
-0.032182038,
-0.0151475705,
0.036296513,
0.012946194,
0.0055165463,
-0.011773436,
0.014256537,
0.035300653,
-0.017938603,
0.019825498,
-0.033728242,
0.01964205,
0.018187568,
-0.021371702,
-0.019248946,
0.017545499,
-0.00949999,
-0.00061545195,
0.012526884,
-0.0077637853,
0.018947568,
0.012847918,
0.02658687,
-0.006335511,
0.00808482,
-0.01495102,
0.008327233,
0.00015161083,
0.0022849115,
-0.010738265,
0.012618608,
-0.0029368075,
-0.006233959,
0.009821025,
-0.01636619,
-0.014964122,
-0.021594461,
-0.010731713,
0.008425509,
-0.0047467193,
0.027202731,
-0.0009770249,
-0.00054543046,
0.017440671,
-0.0042848233,
0.0027320662,
0.002944997,
-0.010430334,
0.011124817,
0.0032070656,
0.011164127,
-0.0010982316,
-0.0081896465,
-0.015501363,
-0.0030023246,
-0.017034465,
0.02113584,
0.016444812,
0.011308264,
0.0028925834,
-0.0029417211,
0.021031013,
0.014492399,
-0.026049629,
0.031028934,
0.017820671,
-0.016995154,
0.012579298,
0.01167516,
0.012821711,
-0.020533083,
0.0014823261,
0.0027238766,
-0.01934067,
-0.0054215463,
0.0033643069,
0.017571706,
0.030295141,
0.016759293,
-0.011203437,
-0.024333078,
0.0055362014,
0.025420664,
-0.015933776,
0.0072199926,
-0.0033086173,
-0.01662826,
-0.007003786,
-0.036034446,
-0.021869633,
0.016693776,
-0.011852057,
-0.0023979286,
0.008936543,
0.013653779,
-0.007436199,
0.026088938,
0.014426881,
-0.016916534,
0.0036427549,
0.03155307,
0.035090998,
-0.02269515,
0.0034396516,
-0.019235842,
0.001135085,
-0.01419102,
0.015252398,
0.017728947,
0.0054837875,
0.004245513,
-0.018895153,
-0.012919987,
0.0025682733,
0.008248612,
0.004088272,
0.0043503405,
0.0059063733,
0.017073777,
-0.01312309,
-0.013614469,
0.015658604,
0.011262402,
0.0044355127,
0.006951372,
-0.005107064,
-0.0013906021,
0.0080913715,
-0.0016207311,
-0.027307559,
-0.0035117206,
0.02998066,
0.02013998,
-0.0026632731,
0.0056901667,
0.020231703,
0.000015944219,
0.0048580985,
0.0012947832,
-0.028932385,
-0.03346617,
0.0018410326,
0.06368269,
0.021974461,
-0.009899645,
0.03181514,
0.011550678,
-0.011819298,
0.0026714627,
-0.008523785,
0.021974461,
0.007599992,
-0.0066041313,
-0.008615509,
0.023900665,
-0.017309638,
0.00072887854,
0.016654465,
0.010764472,
-0.019471705,
-0.019956531,
0.009807921,
0.034357205,
-0.012081367,
0.017086878,
0.035903413,
0.018672395,
-0.0009942232,
0.008196198,
0.017348947,
0.006833441,
-0.014177917,
0.010836541,
0.008065164,
-0.021542046,
0.036794446,
-0.0054772357,
0.0037737892,
0.027726868,
-0.0023340494,
0.02838204,
0.0048941327,
0.02223653,
0.01854136,
0.0012579297,
0.0065812003,
0.012022401,
0.017820671,
-0.002592842,
0.028119972,
0.006099649,
-0.022865495,
0.038812373,
-0.016654465,
0.0066270623,
-0.024752388,
0.016051708,
-0.025276527,
0.005801546,
0.0070824064,
-0.0077834404,
0.004939995,
-0.012042057,
-0.015894467,
0.019773083,
-0.0048974087,
-0.014125503,
-0.030347556,
-0.031631693,
0.0061520627,
-0.016497225,
0.006767924,
-0.0013840504,
-0.006440338,
-0.010246886,
0.020716531,
-0.0044093058,
0.019393085,
0.025289629,
0.0125858495,
0.010286196,
0.007862061,
-0.011589988,
-0.0029826693,
-0.011399988,
-0.017375154,
0.024922734,
-0.008949646,
-0.000626508,
-0.03860272,
-0.03399031,
-0.02025791,
-0.020480668,
0.009617921,
0.00625689,
0.010201024,
-0.0010990506,
-0.0060472353,
-0.0040227547,
-0.012448263,
0.0070627513,
-0.024044802,
-0.009545852,
-0.027831696,
-0.037397202,
-0.0064141313,
0.028853763,
-0.0019573255,
-0.03566755,
-0.009532749,
-0.0028221523,
-0.029692383,
0.02155515,
-0.016431708,
0.0152917085,
0.013044469,
0.01499033,
0.029194454,
0.017414466,
0.005261029,
0.043346163,
-0.015527571,
-0.01854136,
0.00064329675,
0.0112820575,
0.0053658565,
-0.028696522,
0.014898606,
0.002063791,
-0.017833775,
-0.045233056,
-0.0106530925,
-0.005107064,
0.017414466,
0.004170168,
-0.019602738,
-0.011301713,
-0.0033315483,
-0.023468252,
0.0029613762,
-0.027359972,
-0.020205496,
-0.002920428,
-0.024280665,
0.011190333,
-0.034488242,
0.036034446,
-0.040489614,
0.009473784,
0.010076541,
0.0038687892,
0.03647996,
-0.013679986,
0.0183055,
-0.01033861,
0.01742757,
-0.021463426,
-0.021031013,
-0.005699994,
0.0054215463,
0.02361239,
0.0065680966,
0.051182017,
0.012539987,
0.02586618,
0.014636537,
0.033780657,
-0.0034396516,
0.019314462,
0.01201585,
-0.006279821,
0.018135155,
0.023979286,
0.011354126,
-0.008510681,
-0.003665686,
0.01812205,
0.040332373,
-0.015684811,
-0.04219306,
-0.02029722,
-0.029666176,
0.015881363,
-0.0011776712,
-0.009893093,
0.024215147,
-0.03726617,
-0.009847231,
0.03380686,
-0.010443438,
0.024739286,
-0.0005053012,
0.003754134,
-0.026390318,
0.03207721,
-0.018973773,
-0.026862042,
-0.0060832696,
-0.02105722,
0.0012734901,
-0.012408953,
0.013352401,
-0.023402736,
0.023953078,
0.0053396495,
-0.020205496,
-0.0055230977,
0.0021293082,
-0.014453089,
-0.010456541,
-0.0009819387,
-0.030662037,
-0.004003099,
-0.019131014,
-0.025171699,
-0.04974064,
-0.0031857726,
-0.0029335315,
-0.026862042,
0.02311446,
-0.021764806,
0.0015388347,
-0.011983091,
-0.0031382726,
0.0066401656,
-0.032601345,
0.031762727,
0.0064141313,
-0.010102748,
-0.03231307,
0.013627572,
0.007167579,
0.009532749,
0.032679968,
0.018253084,
-0.014073089,
-0.017217914,
0.009454128,
0.031002726,
0.004632064,
-0.03883858,
0.032260656,
0.021031013,
-0.021463426,
0.008877577,
-0.014466193,
-0.03611307,
-0.004612409,
-0.0061356835,
-0.025079975,
-0.010063438,
-0.019353773,
-0.010443438,
0.022760667,
-0.016313776,
0.033780657,
0.013588262,
-0.007907923,
-0.001899998,
-0.02563032,
-0.009178956,
0.014911709,
-0.0004917883,
0.025237216,
0.00029503202,
0.015894467,
0.017099982,
0.0032873242,
0.007613096,
0.015514467,
-0.01312309,
0.027019283,
-0.0019818945,
-0.029063419,
-0.00030445014,
-0.004749995,
0.008045509,
0.0047663744,
-0.0071282685,
-0.013018263,
-0.01670688,
-0.026010318,
0.0048875813,
0.015173778,
-0.025931697,
-0.007816199,
-0.033020657,
0.008844819,
-0.0026943937,
-0.029875832,
0.016300673,
-0.016287569,
-0.02666549,
0.008838267,
-0.014806882,
0.012487574,
-0.0014987054,
-0.017991016,
-0.017244121,
-0.0005515727,
-0.016837914,
0.043503404,
0.020362739,
0.003475686,
-0.008969301,
0.02067722,
-0.022983424,
-0.0036755134,
0.019432394,
-0.010620334,
-0.024844112,
0.009748955,
0.005129995,
0.0040948233,
-0.018751016,
-0.00831413,
0.022747563,
0.019524118,
0.0009884904,
-0.0071479236,
-0.003937582,
0.031212382,
-0.019956531,
0.0066434415,
0.01770274,
-0.017611017,
0.0066630966,
-0.01884274,
0.030321348,
0.008045509,
-0.03582479,
0.0055001667,
-0.021214461,
0.035090998,
-0.0035379275,
0.012205849,
-0.032286864,
-0.014335158,
-0.011399988,
0.042088233,
-0.014335158,
-0.010947919,
0.02525032,
0.006584476,
-0.001112154,
-0.003783617,
-0.006538614,
-0.017231017,
0.003996548,
-0.008779301,
-0.029535143,
0.0029269797,
-0.009552404,
0.033937898,
0.023625493,
-0.019458601,
-0.02612825,
-0.014728261,
-0.037606858,
0.00835344,
-0.00987999,
0.009585163,
-0.0064829243,
0.016379293,
0.007999647,
0.021070324,
-0.014597227,
0.028224798,
-0.032444105,
0.0005499348,
0.0020064635,
0.0048744776,
0.021961357,
-0.014846192,
-0.008438612,
-0.004612409,
0.026940662,
-0.0137324,
0.0033806863,
0.028486868,
0.01690343,
0.004098099,
-0.02770066,
0.027779281,
0.018947568,
-0.03490755,
0.023533769,
0.009093784,
-0.014204123,
0.0068072346,
0.001576507,
-0.011019989,
-0.012251711,
-0.0011522833,
-0.000066284956,
-0.002528963,
-0.009919301,
0.0047860295,
0.016064811,
-0.007462406,
0.03005928,
0.006168442,
0.0107513685,
0.014164813,
0.020192394,
0.014256537,
-0.009224818,
0.0136013655,
-0.0036296514,
0.0024699974,
0.02498825,
-0.0013390073,
-0.018685497,
-0.017689638,
0.01728343,
-0.0077899923,
0.0073837857,
0.010096197,
-0.0431103,
-0.00236517,
0.0070365444,
-0.009506542,
0.0025912044,
0.00037529058,
0.026704801,
0.0009786627,
-0.008805509,
-0.0053003393,
-0.011930677,
-0.0060865455,
-0.0020244806,
0.0081437845,
-0.018475844,
0.01461033,
-0.01419102,
-0.010646541,
-0.009709645,
0.028460661,
0.17673913,
-0.00034765052,
-0.007305165,
0.007121717,
-0.007652406,
0.0023029286,
0.029063419,
0.008366543,
0.011753781,
0.0025174974,
-0.01377171,
0.036899272,
-0.008071716,
0.00885137,
-0.001994998,
0.0032906001,
-0.048928227,
-0.012330332,
0.010476196,
-0.00635189,
-0.02624618,
-0.013431021,
-0.0133130895,
-0.005863787,
0.03422617,
0.0043470645,
-0.025997214,
0.031657897,
0.01796481,
-0.0016772397,
-0.0071086134,
0.0021981013,
-0.00054338307,
0.0023700837,
-0.0097358525,
-0.008464819,
0.012415505,
-0.02163377,
-0.0043765474,
-0.0049465466,
0.01121654,
0.021725494,
0.006564821,
0.0017935326,
-0.0006899777,
0.034619275,
-0.004199651,
-0.01934067,
-0.0072330963,
0.0034625826,
-0.010456541,
0.0051824087,
0.021843426,
0.018868946,
-0.028617902,
0.022564115,
-0.0065713725,
0.005657408,
-0.010305852,
0.01167516,
-0.0019818945,
0.029142039,
-0.0127824005,
0.028067557,
-0.018357912,
0.030164108,
0.0006920252,
-0.021450322,
-0.021895839,
-0.004582926,
0.0062208558,
-0.020860668,
-0.00061749935,
0.0140861925,
-0.027071696,
-0.013915848,
0.027150318,
0.02025791,
-0.00030567858,
0.012291022,
-0.002548618,
-0.010220679,
-0.02963997,
0.0060472353,
-0.03535307,
-0.024896527,
-0.010836541,
0.021843426,
-0.014256537,
-0.0059882696,
-0.00089349045,
-0.002664911,
-0.0071610273,
0.0010122403,
-0.017650327,
-0.0018197396,
-0.0037017204,
-0.002643618,
0.00086236984,
-0.0028156005,
-0.025591008,
0.066670276,
0.013575159,
0.02696687,
-0.008097922,
-0.017755155,
-0.015199984,
0.018436532,
0.0055132704,
-0.0025240493,
-0.0033184448,
-0.022275839,
0.0047827535,
0.000115781135,
0.0043437886,
-0.0016608604,
0.004704133,
-0.025394456,
0.014295847,
-0.0044649956,
0.021188254,
-0.046255127,
0.01926205,
0.033282723,
-0.02498825,
-0.004586202,
-0.007940682,
-0.003151376,
-0.009925852,
-0.015501363,
0.028329626,
-0.058074422,
-0.027857903,
-0.010174817,
-0.009093784,
-0.005192236,
0.003131721,
-0.0007833397,
0.012795504,
0.025211008,
-0.019812394,
-0.024477217,
0.0017787913,
-0.003501893,
0.01892136,
-0.025171699,
0.010692403,
0.0015912484,
0.0023340494,
-0.011413092,
-0.010286196,
0.003459307,
0.016916534,
-0.001182585,
0.00404241,
-0.0060701664,
-0.021031013,
-0.038209617,
0.006997234,
0.0009237922,
-0.0142303305,
0.021804115,
0.023062045,
-0.0070430962,
-0.009604818,
0.00005850479,
-0.1647888,
0.031264797,
0.016222052,
-0.026560662,
0.019733774,
-0.016431708,
0.026573766,
0.00881206,
-0.015711019,
0.0012038781,
0.01144585,
0.0020293945,
-0.015658604,
0.010115852,
-0.014544813,
-0.0060603386,
-0.017493086,
0.02712411,
0.014584123,
0.018318603,
0.012841366,
-0.017322741,
0.029430315,
0.004478099,
-0.00053273654,
0.02209239,
0.004681202,
0.036820654,
-0.011681712,
-0.011360678,
-0.021869633,
-0.0044649956,
0.0228917,
0.0053429254,
-0.030085487,
0.011832402,
-0.0013406451,
-0.008785853,
0.003731203,
0.0038949961,
0.031841345,
0.027281351,
0.014243434,
0.008071716,
0.0012292659,
0.025997214,
0.0021260323,
-0.015278605,
0.012736538,
-0.016222052,
0.017073777,
-0.005287236,
0.009873439,
-0.0060668904,
-0.011072403,
-0.0076589575,
-0.004127582,
0.0050382707,
0.012520332,
-0.01464964,
-0.0034232724,
-0.001693619,
0.012520332,
0.012644814,
0.034121346,
-0.024215147,
-0.003154652,
0.006846545,
-0.03456686,
-0.010869299,
-0.041485474,
-0.026180662,
-0.004661547,
-0.019589635,
0.005631201,
0.018017223,
-0.0032070656,
0.0053855116,
-0.0018492222,
0.010305852,
-0.008720336,
0.005657408,
-0.02574825,
0.012736538,
-0.01972067,
-0.005850684,
0.015645502,
0.002037584,
0.005139822,
-0.02029722,
0.0018148257,
-0.029456522,
0.005896546,
-0.029404107,
0.02929928,
0.020624807,
-0.006879303,
0.007829302,
0.013640676,
-0.00375741,
-0.003570686,
-0.011092057,
-0.04151168,
0.016313776,
0.028172385,
-0.021214461,
-0.0034199965,
-0.009264128,
0.035955824,
-0.004494478,
0.005791718,
0.010679299,
0.0040915473,
0.0079472335,
0.0039048237,
0.041328233,
-0.024215147,
-0.0014585761,
0.01712619,
-0.017440671,
0.043084092,
0.0056934427,
-0.012330332,
0.010482748,
-0.0066008554,
-0.00011004838,
-0.12495436,
-0.003806548,
-0.0007739216,
-0.001461033,
0.011000333,
0.0067155105,
-0.018502051,
-0.00013686948,
-0.008071716,
0.03467169,
-0.032522727,
-0.028748937,
-0.0037737892,
0.0046517192,
0.036637206,
-0.018908257,
0.00946068,
-0.028539281,
-0.01964205,
0.047355812,
0.00019194484,
-0.024477217,
-0.016995154,
-0.010777575,
-0.005817925,
-0.0060406835,
-0.025918594,
0.00732482,
0.008681025,
0.0020752565,
0.002592842,
-0.01495102,
0.035195827,
-0.0082879225,
-0.0040456858,
-0.0035674102,
-0.0077375784,
-0.003107152,
-0.011052747,
-0.01182585,
0.0037017204,
0.03315169,
0.02586618,
0.0030285313,
0.021214461,
-0.0047434433,
-0.010581024,
-0.0054510287,
0.017873086,
-0.030766865,
-0.021463426,
-0.002923704,
-0.040227544,
-0.0050874087,
0.004566547,
-0.014859295,
0.0069906823,
0.009224818,
0.02998066,
0.013666882,
-0.021974461,
0.011688264,
-0.041433062,
0.019091705,
0.020441359,
-0.033361346,
-0.021961357,
-0.03799996,
0.0066827517,
-0.03063583,
-0.017191706,
0.014571019,
-0.002021205,
0.010391024,
-0.021502737,
0.0028925834,
-0.034278587,
-0.02570894,
-0.0059456835,
-0.022721356,
-0.0024044802,
-0.021070324,
0.017925499,
-0.0066630966,
-0.003760686,
-0.004455168,
0.0014675847,
0.004104651,
-0.008975853,
-0.010856196,
0.015658604,
0.019157222,
0.037397202,
-0.028224798,
0.014702054,
0.028198592,
0.011662057,
-0.030164108,
0.016497225,
-0.02010067,
-0.023337217,
0.00039924527,
-0.035143413,
0.020952392,
0.0067548207,
-0.005382236,
-0.0055984426,
-0.005401891,
-0.0076851645,
-0.017991016,
-0.0112820575,
0.021568254,
-0.019144118,
0.031133762,
-0.015763432,
0.0060505113,
-0.022931011,
-0.020913081,
0.023677906,
0.018947568,
0.01888205,
0.026298594,
0.011642402,
0.003410169,
0.0137324,
0.029482728,
-0.010404128,
-0.005008788,
0.00096064556,
0.010063438,
0.012238609,
0.0062274076,
0.020952392,
-0.036532376,
0.0054117185,
0.00034150828,
-0.016339984,
-0.01117723,
-0.00017556555,
0.021358598,
0.048430294,
0.048928227,
-0.0023471527,
-0.0017116362,
-0.013431021,
-0.0070365444,
0.0042946506,
0.0032152554,
-0.008510681,
-0.005293788,
0.00094508525,
-0.00560827,
0.04431582,
0.005146374,
0.005247926,
-0.026010318,
-0.0024372388,
-0.00062978384,
0.0022898254,
0.02139791,
-0.017820671,
-0.015199984,
0.016313776,
-0.028906178,
0.0005098055,
0.019065497,
0.014387571,
-0.02754342,
0.0020031875,
0.021266876,
-0.007855509,
-0.028775143,
-0.02956135,
-0.012363091,
-0.025053767,
0.007822751,
-0.0043732715,
0.00053150806,
-0.002411032,
0.026731007,
-0.008215854,
0.017375154,
-0.010659644,
0.014204123,
-0.010482748,
0.039886855,
0.0081896465,
-0.013928952,
-0.019078601,
0.016222052,
-0.009427922,
0.01544895,
-0.017846879,
0.015003433,
0.01876412,
-0.0023602562,
-0.0068072346,
0.028460661,
0.0055493047,
-0.009965163,
0.01949791,
0.0023242217,
0.021725494,
-0.014675847,
-0.017938603,
-0.031631693,
-0.02582687,
0.010869299,
-0.020153083,
-0.029168246,
0.00025449326,
0.0059686145,
0.0093034385,
0.0167855,
0.0038556857,
0.0021194806,
-0.027753076,
0.015239295,
0.0034855136,
0.0008271543,
-0.01808274,
0.014793778,
0.01808274,
0.013090331,
0.009047922,
-0.012395849,
0.014977226,
0.022459287,
0.0030989624,
-0.023677906,
0.0492165,
-0.0117668845,
-0.007541027,
0.0038458582,
-0.02644273,
-0.0028008593,
-0.0016968949,
-0.029037211,
0.019366877,
0.006188097,
0.0038589616,
0.064835794,
-0.009146198,
0.0004819607,
0.009539301,
0.0049956846,
0.0013832314,
0.016431708,
-0.013915848,
-0.0008959474,
-0.014479295,
-0.0043503405,
-0.011000333,
0.026835835,
-0.011341023,
0.0012137056,
0.016077915,
-0.019327566,
0.0034363759,
-0.016680673,
-0.010856196,
-0.0005749132,
0.00009950421,
0.015265502,
0.030373761,
-0.02704549,
0.0026370662,
0.0132148145,
0.002992497,
0.0005384693,
-0.02738618,
-0.002619049,
0.018672395,
-0.0076196473,
0.00095655076,
0.028565489,
-0.025446871,
-0.0154358465,
0.009087232,
0.002946635,
-0.0054313736,
0.012448263,
-0.0054182704,
-0.027674455,
0.015422743,
-0.0160255,
-0.027333764,
-0.01377171,
-0.02971859,
-0.01624826
] |
The ER-associated degradation (ERAD) pathway serves as an important cellular safeguard by directing incorrectly folded and unassembled proteins from the ER to the proteasome. Still, however, little is known about the components mediating ERAD of membrane proteins. Here we show that the evolutionary conserved rhomboid family protein RHBDL4 is a ubiquitin-dependent ER-resident intramembrane protease that is upregulated upon ER stress. RHBDL4 cleaves single-spanning and polytopic membrane proteins with unstable transmembrane helices, leading to their degradation by the canonical ERAD machinery. RHBDL4 specifically binds | [
-0.016066976,
-0.0022712126,
-0.0063452423,
-0.035719365,
0.0020841914,
0.03388622,
-0.008080664,
-0.008714178,
-0.014597764,
0.012663526,
0.011436936,
-0.011612164,
-0.0016941426,
0.0122658955,
-0.022712126,
0.019841097,
0.01587827,
0.0039459793,
0.009799237,
0.019584997,
-0.029249443,
0.007076478,
-0.004043702,
-0.011598685,
0.007177571,
-0.003228222,
0.039439574,
-0.029950352,
0.0047210217,
-0.015406504,
-0.0057723843,
-0.019045835,
-0.008896144,
-0.0021886537,
0.016511783,
-0.002357141,
0.020649837,
-0.0009671187,
0.011699777,
-0.0019494013,
0.038684748,
-0.014099041,
-0.0028811377,
0.0046704756,
0.007743689,
-0.005859998,
0.00052526005,
-0.01193566,
-0.020528527,
0.018641466,
0.017751852,
-0.0046569966,
-0.010001423,
-0.004545795,
-0.0022274058,
0.0030428856,
-0.00071186,
0.016309598,
0.030058185,
-0.0020825064,
-0.005886956,
-0.013128553,
-0.026917575,
0.0041110967,
0.0059914184,
0.038145587,
0.0076156384,
-0.0040066345,
0.02129683,
0.0013394762,
0.049818408,
0.005721838,
-0.012400686,
-0.005718468,
0.03121738,
-0.04030223,
-0.025488801,
-0.009293775,
-0.0028575493,
-0.00097217335,
0.007116915,
-0.022833437,
0.0008879295,
0.023345638,
0.011767172,
-0.029626856,
-0.013627276,
0.026661474,
0.0025559566,
-0.007103436,
-0.0017455313,
0.019625433,
0.01560869,
-0.005374754,
-0.017832726,
0.002224036,
0.0050546275,
0.03509933,
-0.016026538,
-0.006011637,
-0.01626916,
0.029411191,
-0.012508518,
-0.009549876,
-0.03135217,
-0.015285193,
-0.014436016,
-0.010486667,
0.017185733,
-0.0013992894,
-0.01802143,
0.019854575,
0.0018499936,
-0.02589317,
0.009300514,
-0.012515257,
0.02210557,
0.012023274,
0.0009443729,
-0.0114841135,
0.000048045287,
0.026054919,
0.016848758,
-0.027631963,
0.035665452,
0.00162759,
-0.003986416,
-0.014247309,
0.022900831,
-0.011032566,
0.0073191,
0.013128553,
-0.0010960117,
-0.011039306,
-0.0029080957,
0.01655222,
-0.0068068984,
-0.011046045,
-0.015136924,
-0.029815562,
0.024518313,
0.021809032,
-0.034263633,
-0.0017371069,
0.0030142427,
0.020690275,
0.008040227,
0.023413034,
-0.021660764,
0.018816693,
-0.01261635,
0.0060925107,
0.008154799,
-0.039116077,
0.002047124,
0.03350881,
-0.028656367,
0.00034055553,
-0.0045794924,
-0.021499015,
-0.014125998,
0.0106686335,
0.009947507,
-0.014651679,
0.024343085,
0.013007241,
-0.004191971,
0.023952194,
0.0072651845,
-0.011369542,
-0.01411252,
0.026230147,
-0.0292764,
0.014072083,
-0.008330026,
0.0041009877,
0.0021633806,
0.0065002507,
-0.032241784,
-0.010756247,
0.0077571683,
-0.011416718,
0.024086984,
0.0005737002,
-0.0031827304,
-0.0008285377,
0.013404871,
-0.003363012,
-0.0032484406,
-0.023129975,
-0.02008372,
0.027065845,
0.0013445308,
-0.025192263,
-0.61938727,
-0.038469084,
0.0004313282,
0.0030883774,
-0.036096778,
0.020690275,
0.012299594,
0.018668424,
-0.0018634726,
0.013546402,
-0.0069484278,
0.014543848,
0.00447503,
-0.030435596,
-0.018654944,
-0.0126567865,
-0.013216166,
-0.010062078,
0.023979152,
-0.021458577,
-0.03811863,
0.005361275,
-0.017522708,
0.0022172965,
0.009415086,
0.008619824,
0.00909159,
-0.030678218,
-0.0023638806,
0.025394447,
-0.008431118,
0.02957294,
-0.0055263927,
0.01953108,
0.04989928,
-0.010486667,
-0.023561303,
0.027793711,
0.04270149,
0.01722617,
-0.0058768466,
0.0032484406,
0.018061869,
0.00083232863,
-0.0034775836,
0.007952614,
0.013593578,
-0.0067799403,
0.001791023,
-0.0024767674,
-0.002427906,
0.0006052916,
-0.0032821381,
-0.009394867,
0.0005715941,
0.021660764,
0.022927789,
-0.033293147,
0.01153803,
0.01369467,
-0.0069956044,
0.02157989,
-0.0134857455,
-0.019167148,
-0.019921971,
-0.013276821,
-0.025839254,
0.010924734,
-0.01166608,
0.0048760306,
-0.0041245758,
0.013735107,
0.0039560883,
0.013627276,
0.0032770834,
0.036608983,
-0.0031389236,
0.0252327,
-0.009644229,
0.022482982,
0.020595921,
0.0028103727,
-0.010048599,
0.0075212857,
0.023615219,
0.016120892,
-0.014557327,
0.04014048,
-0.0014329868,
0.009529658,
0.022011217,
-0.0063991584,
-0.012683745,
-0.04326761,
-0.014193393,
0.01628264,
-0.017846204,
0.017684456,
-0.0007674609,
-0.014260788,
-0.008397421,
-0.004080769,
0.007939135,
-0.009334212,
0.017711414,
0.00069753855,
-0.021916864,
-0.0064766626,
0.029680772,
-0.010014902,
-0.011430197,
0.0013917075,
0.00365955,
0.005186048,
-0.039574362,
-0.030192975,
0.0102642635,
0.016040018,
0.028171124,
-0.033805348,
0.026068399,
-0.031379126,
0.009084851,
-0.013910335,
0.0069214697,
0.007817823,
0.011416718,
-0.027631963,
0.0061834943,
0.005782494,
-0.009779019,
0.0031136505,
0.033427935,
-0.01016317,
0.020312862,
0.032673113,
0.0007068054,
-0.0034539953,
-0.012366989,
-0.041838836,
-0.009987944,
-0.019962408,
-0.0033259448,
-0.016471345,
-0.03760643,
-0.028386787,
0.0034742139,
0.011308886,
0.027578047,
0.017145297,
0.014139477,
0.010506885,
-0.028925948,
0.010796684,
0.013270082,
-0.021391183,
-0.027241072,
-0.02089246,
-0.008228933,
-0.007959353,
0.005401712,
0.021404661,
-0.027901543,
0.009152246,
-0.0028019485,
-0.02984252,
0.0322957,
-0.003851626,
-0.015083008,
-0.029653814,
-0.007817823,
0.0011238122,
-0.031540874,
0.017590104,
0.0039796764,
0.02738934,
-0.0012762934,
-0.015312151,
0.012946585,
0.010789945,
0.0007607214,
0.00048861396,
0.005681401,
-0.03278094,
0.017549666,
0.026674954,
0.015581732,
0.0170779,
0.014772991,
0.02008372,
-0.0014355142,
0.035314996,
0.007649336,
0.0039965254,
-0.0003310781,
-0.025340531,
0.026971491,
0.02087898,
0.0046334085,
0.026782785,
0.005718468,
-0.024356565,
0.015986102,
-0.012542215,
-0.017805768,
0.003133869,
-0.0069416882,
-0.0067058057,
0.00814132,
-0.006975386,
-0.01764402,
-0.014409058,
-0.009974465,
-0.010095776,
-0.02659408,
0.015851311,
-0.009799237,
0.004690694,
-0.027335424,
-0.014260788,
0.008869186,
-0.009408346,
0.015217798,
-0.011275189,
-0.011268449,
-0.0026789524,
-0.016592657,
0.028602451,
0.007918917,
-0.023116495,
0.02714672,
0.024208296,
0.025623592,
0.024086984,
-0.013243124,
0.003999895,
0.003214743,
0.00773021,
0.033347063,
-0.031433042,
-0.021242915,
0.010506885,
-0.021782074,
0.010891037,
-0.012434383,
0.002928314,
0.012926367,
0.014166435,
0.0019544559,
0.019868055,
-0.019962408,
0.028979864,
-0.026823223,
0.00922638,
-0.00015669345,
-0.01776533,
0.0061396873,
0.027079323,
0.055371758,
0.015932186,
0.013034199,
0.014166435,
0.0029485326,
-0.010028381,
0.025664028,
0.0035584576,
0.0061059897,
-0.009522918,
-0.010931474,
-0.012393946,
0.0003199158,
-0.0077841263,
-0.020595921,
-0.024033068,
-0.004896249,
0.030300805,
-0.011457155,
0.0052264845,
0.007918917,
0.01763054,
-0.024302648,
-0.018641466,
0.013391392,
0.010493406,
-0.033266187,
-0.020663317,
-0.04191971,
0.0076830336,
-0.0039257607,
0.036447234,
0.011922181,
0.021458577,
0.014665158,
0.030166017,
0.0007691458,
-0.0024312758,
0.042000584,
-0.028494619,
0.030678218,
-0.008902884,
0.0078313025,
0.0003710939,
-0.011679559,
-0.012575913,
0.040383104,
0.0013824406,
-0.0012687115,
-0.00006165593,
-0.01153129,
-0.02509791,
-0.018210137,
0.0024245363,
0.0023638806,
-0.0017960776,
-0.019638913,
-0.012899409,
-0.020542005,
0.0065979734,
0.034694962,
0.031945243,
-0.014840386,
-0.019045835,
-0.0027581416,
0.012137845,
0.030462554,
0.044723343,
-0.009671187,
0.03132521,
0.016619615,
0.018115785,
-0.0072651845,
-0.040706597,
0.013580099,
0.0068844026,
-0.008168278,
-0.025340531,
0.0036393318,
0.0025054102,
0.0016503358,
0.02032634,
0.00882201,
-0.023911757,
0.023345638,
-0.0024464396,
0.013094855,
-0.015473899,
0.011335844,
0.017859682,
0.0292764,
-0.0019763594,
0.0072651845,
0.007898698,
0.004818745,
-0.011511072,
0.010567541,
0.022617772,
-0.010837121,
0.013195947,
-0.00125439,
-0.04191971,
0.013795763,
0.006466553,
0.018533634,
0.0130813755,
0.012899409,
0.011046045,
0.0046974337,
0.012730922,
-0.00047218645,
0.0005817034,
0.0018938003,
0.01938281,
-0.0029333688,
-0.01965239,
0.0049164677,
-0.0150964875,
-0.01220524,
-0.025677508,
0.007298882,
-0.027739795,
0.023574783,
-0.014395579,
-0.000738818,
-0.029330317,
-0.0051220222,
0.008370463,
0.018358406,
-0.0005025142,
0.012528736,
0.005681401,
-0.01694311,
-0.014301226,
-0.013229645,
-0.0042896937,
-0.019167148,
-0.03270007,
-0.028521577,
0.026958013,
-0.0059172837,
0.028710283,
0.009624011,
0.0036561803,
0.0028423856,
0.0073460583,
-0.011140399,
-0.013937293,
0.01357336,
-0.04014048,
-0.023534345,
0.022442546,
0.0038785841,
-0.031028673,
-0.028521577,
0.016794842,
0.02157989,
-0.006796789,
0.037902966,
0.0006667896,
-0.0004045808,
0.004232408,
0.028737241,
0.028791158,
0.006759722,
-0.015163882,
-0.01275114,
-0.001186995,
-0.019558039,
-0.014355142,
0.010931474,
0.003132184,
-0.0073393187,
-0.005142241,
0.008168278,
-0.026971491,
-0.027497172,
0.014894302,
-0.022226881,
0.0014633146,
0.013323998,
0.01451689,
-0.019207584,
0.018978441,
0.00086349883,
0.0031170202,
-0.016740926,
-0.017118338,
0.019975888,
0.00055011193,
-0.018007953,
0.030839967,
-0.0023857842,
-0.037660345,
-0.008451337,
0.00145826,
-0.01126171,
0.03744468,
0.0058532585,
-0.017334003,
-0.02713324,
-0.009367909,
0.0017244704,
0.004818745,
-0.009563355,
-0.0190054,
-0.015123445,
-0.008511992,
-0.00047429252,
0.014624721,
-0.010203607,
-0.03135217,
-0.012521997,
0.01938281,
-0.006823747,
0.007487588,
-0.0006697381,
-0.006850705,
-0.017104859,
-0.002090931,
-0.018479718,
-0.03687856,
0.00895006,
0.012340031,
0.030058185,
0.02143162,
0.026472768,
-0.015123445,
0.01260961,
0.035827197,
0.027456736,
-0.0037067267,
-0.0060048974,
-0.014719075,
-0.025664028,
0.0398709,
0.02482833,
-0.0006090826,
0.005492695,
-0.019477164,
0.0053916024,
0.009138767,
0.009253338,
-0.02183599,
0.020043282,
-0.03431755,
-0.03782209,
0.018479718,
-0.019059315,
-0.026809743,
-0.03213395,
-0.018803215,
-0.009671187,
0.007763908,
0.008842228,
-0.023776967,
0.009792498,
-0.013189208,
0.03577328,
0.005883586,
0.0051523503,
0.010399054,
-0.02047461,
0.011511072,
-0.00623741,
0.03553066,
-0.011524551,
-0.0064732926,
-0.0046334085,
-0.005819561,
-0.0050242995,
0.011955879,
0.0012265895,
-0.014988655,
-0.007804345,
-0.01071581,
0.0022425696,
-0.030327763,
-0.012461341,
-0.045882538,
0.011591946,
0.006163276,
-0.013040938,
0.020663317,
0.002822167,
-0.01519084,
0.008619824,
-0.0060554435,
0.016646573,
-0.009482481,
0.021485535,
0.038981285,
-0.0046030805,
-0.028656367,
-0.0074538905,
-0.00003532974,
0.003757273,
0.028791158,
0.027739795,
0.0022408848,
-0.024936162,
-0.0072112684,
-0.0074538905,
-0.023776967,
-0.044912048,
0.040544853,
-0.00070132955,
0.014355142,
0.015204319,
0.00678331,
-0.0062744776,
0.004572753,
-0.030058185,
0.01695659,
-0.016296118,
-0.0021532713,
-0.024572229,
0.014018167,
-0.011430197,
0.01560869,
-0.00582967,
-0.03202612,
-0.0003894169,
-0.015406504,
0.010992129,
-0.0015104911,
0.0051523503,
0.018344928,
0.0055398718,
-0.007804345,
0.019827617,
0.016323077,
0.015716521,
-0.029896436,
-0.007231487,
0.027362382,
-0.0143821,
-0.007804345,
0.011436936,
-0.007824563,
-0.005859998,
-0.007939135,
0.00814132,
-0.0024733976,
-0.027631963,
-0.01098539,
0.023359118,
-0.0012805056,
0.0010303016,
0.010992129,
-0.03388622,
0.0012611295,
-0.035314996,
-0.025785338,
0.0131015945,
-0.04965666,
-0.010904516,
0.0021263133,
0.0033866004,
0.04138055,
0.021782074,
0.021391183,
-0.007298882,
0.02077115,
-0.02358826,
0.022024697,
0.014826907,
0.009556616,
-0.023022143,
-0.010479927,
-0.017320523,
-0.026081877,
0.019099751,
-0.0138968555,
-0.019099751,
0.0138968555,
-0.024504833,
0.004990602,
0.031163463,
-0.0287642,
0.013842939,
-0.028171124,
0.03172958,
0.00079526135,
-0.02319737,
0.030462554,
-0.018830173,
0.011854786,
0.003445571,
0.008397421,
-0.024491355,
0.008774833,
-0.012144584,
-0.029734688,
-0.0006116099,
-0.0018146113,
-0.013202687,
0.009381388,
-0.0057993424,
-0.012124366,
0.0024733976,
0.005671292,
-0.006928209,
0.006887772,
0.009718363,
-0.007804345,
0.0074538905,
0.0016882456,
-0.00420882,
0.00011457155,
-0.006163276,
-0.013600318,
0.00976554,
-0.008026748,
-0.0132903,
-0.014301226,
-0.034668006,
0.046745192,
-0.0022526789,
-0.020717233,
0.0020370148,
0.010142952,
-0.022119049,
-0.01670049,
-0.0214451,
0.0067799403,
-0.005681401,
0.020447653,
0.004269475,
0.0019022247,
-0.012575913,
0.013391392,
0.020784628,
-0.015029092,
0.00047050157,
-0.032376572,
0.010338398,
0.0020791367,
-0.044130266,
-0.010513625,
0.03639332,
-0.006126208,
-0.0018011322,
0.033616643,
-0.010385575,
0.015446941,
-0.0027800451,
0.014840386,
0.018088827,
0.014166435,
0.012340031,
-0.03388622,
-0.0069484278,
0.0030664739,
0.006038595,
-0.017023984,
0.017792288,
0.035746325,
0.007905438,
-0.010560801,
-0.00610262,
-0.00365955,
0.0007649336,
-0.02862941,
0.022806479,
0.020528527,
-0.013600318,
0.020905938,
0.010479927,
-0.014018167,
-0.014409058,
-0.01382946,
-0.023615219,
-0.018371886,
-0.002114519,
-0.027847627,
0.0063418723,
-0.01301398,
0.0030445706,
-0.016525261,
0.00023440835,
-0.03038168,
0.00596783,
-0.015554774,
0.022846915,
-0.01764402,
-0.002795209,
-0.012124366,
0.012003055,
-0.02401959,
0.0019510862,
-0.0053073587,
0.009745321,
-0.016983548,
-0.0062711076,
-0.012919627,
-0.021188999,
-0.023156933,
-0.0056342245,
-0.024909204,
-0.0011297092,
0.011632383,
0.19215672,
-0.01234677,
0.022240361,
-0.022159487,
-0.018237095,
-0.011618904,
-0.012110887,
-0.007743689,
0.010021641,
0.0003178097,
0.009880112,
0.013950772,
-0.019288458,
-0.004309912,
0.009731842,
-0.008323287,
-0.026162751,
-0.0031237598,
-0.029788604,
-0.009583574,
0.008343505,
-0.007804345,
-0.010385575,
-0.0013655918,
0.040544853,
-0.00081505865,
-0.04315978,
-0.015433462,
0.0021937082,
-0.0054185605,
-0.019975888,
-0.025610112,
0.009111809,
0.009253338,
0.019423248,
0.00055937876,
-0.016740926,
-0.028656367,
0.015932186,
0.009563355,
-0.0022526789,
0.023628699,
0.015891748,
-0.012703964,
-0.017455313,
-0.011827828,
-0.009273556,
-0.011706517,
0.01750923,
0.006223931,
-0.031810455,
0.01994893,
0.030085143,
0.026270583,
-0.009812716,
-0.02441048,
-0.007662815,
0.017590104,
-0.009812716,
0.026095357,
-0.02277952,
-0.0020808217,
-0.031406086,
0.009819456,
-0.011962618,
0.029492065,
-0.014193393,
0.012993762,
0.03472192,
-0.041030094,
0.023750009,
-0.015649127,
-0.024437439,
-0.005910544,
-0.022927789,
-0.010136213,
0.011982837,
0.0044817696,
0.017913599,
0.029680772,
-0.011012348,
0.017576624,
-0.05345774,
0.009017455,
-0.014826907,
-0.024113942,
0.004181862,
0.014045125,
-0.0061666453,
-0.007925656,
0.0027227593,
-0.012414165,
-0.0063385027,
0.025178785,
0.020676795,
0.014759512,
0.0057487963,
-0.007352798,
-0.005644334,
-0.038684748,
-0.017320523,
0.07720775,
0.024194816,
0.0005269449,
-0.025057472,
0.015730001,
-0.007811084,
0.01126171,
0.016525261,
-0.027631963,
0.00963749,
-0.036096778,
-0.0008230618,
-0.0023975782,
-0.0018230357,
0.01097865,
0.0030664739,
0.00009408978,
0.022577336,
-0.007130394,
0.014220351,
-0.022294277,
0.012542215,
0.01994893,
0.002914835,
0.012043492,
-0.013371174,
-0.0006806898,
0.0037269453,
-0.023345638,
-0.0025980785,
0.011423457,
0.011753693,
-0.0029636966,
-0.0016385417,
0.0044952487,
0.010473188,
-0.008693959,
-0.017293565,
0.006837226,
-0.021350745,
0.018614508,
0.025569675,
0.024599187,
-0.004892879,
0.0000383046,
0.01397773,
0.0062711076,
-0.015891748,
-0.020434173,
-0.012818535,
-0.015541295,
-0.011093223,
-0.035988946,
0.0015399765,
-0.051624592,
-0.023305202,
-0.01993545,
-0.013674452,
0.010109255,
-0.016242202,
0.011322365,
0.03760643,
-0.020016324,
-0.00048608668,
0.0033411088,
-0.17005114,
0.010904516,
0.012050232,
-0.025556196,
0.011416718,
0.021903384,
0.006129578,
0.02331868,
-0.025758382,
0.006389049,
0.025569675,
0.0076830336,
-0.04453464,
-0.03431755,
-0.011140399,
0.027605005,
0.02360174,
0.027294988,
0.007514546,
-0.014799949,
0.019571517,
-0.032511365,
0.0023908387,
0.0006170858,
-0.011996316,
-0.007918917,
0.0030833227,
0.0027766754,
-0.01763054,
-0.0028828224,
-0.020555485,
0.0076965126,
0.04690694,
0.009981204,
0.0033646969,
-0.003703357,
-0.010190128,
-0.00048398058,
0.0042762146,
0.012292854,
0.035908073,
0.025286615,
0.011113441,
-0.00034497833,
-0.0061666453,
0.052702915,
0.010830382,
0.00080368575,
0.019679349,
-0.018385364,
0.012259156,
-0.008330026,
0.0029957092,
0.034371465,
0.037282933,
0.021809032,
-0.0001911281,
0.028979864,
-0.002171805,
-0.011612164,
-0.0263245,
-0.011443676,
0.05591092,
-0.010634936,
0.019841097,
-0.017023984,
-0.007885219,
0.019153668,
-0.0055297622,
0.011174096,
-0.0040605506,
-0.017617062,
-0.0074943276,
-0.0052938797,
0.012919627,
0.022968227,
-0.007258445,
0.018250575,
0.0065406878,
-0.024585707,
0.002562696,
-0.004151534,
-0.0020926157,
-0.017832726,
-0.00909159,
-0.016592657,
-0.012117627,
0.008916363,
0.008565908,
0.0026519946,
0.015339109,
-0.022186445,
0.030300805,
-0.032214824,
0.016713968,
0.020730712,
-0.010621457,
-0.013647494,
-0.019167148,
0.013728368,
0.0155008575,
-0.010129473,
-0.020272426,
0.017994473,
0.009799237,
0.011908702,
-0.0035045417,
-0.011376281,
0.05057323,
-0.015554774,
-0.0012948271,
-0.0016958275,
0.007972832,
0.032915734,
0.010217086,
0.0076695546,
0.0069349487,
0.0018820063,
-0.0046334085,
-0.045154672,
0.075913765,
0.0073123607,
-0.008040227,
0.002726129,
-0.012124366,
-0.04342936,
-0.118183926,
0.011949139,
-0.016484825,
0.00064362254,
-0.015298672,
0.0063957884,
0.0114504155,
0.028548535,
0.010432751,
0.014018167,
-0.02809025,
0.00035298147,
0.0155008575,
-0.021984259,
0.00064572867,
-0.0068844026,
0.017239649,
-0.009340951,
-0.014543848,
0.034883667,
0.0003580361,
-0.021364225,
0.0110797435,
0.0033326843,
0.009158985,
-0.011780651,
-0.03186437,
0.018425802,
0.0009064632,
0.011753693,
-0.0016469661,
0.0035854157,
0.023776967,
0.0138833765,
-0.0025323683,
-0.03256528,
0.015244756,
-0.009563355,
0.025030514,
-0.004141425,
0.0067024357,
0.0065474273,
0.0067428728,
-0.01261635,
0.0045559043,
-0.016376993,
-0.009246598,
0.02427569,
0.016444387,
0.0028423856,
-0.027497172,
-0.029626856,
-0.038603876,
-0.007939135,
0.020366779,
-0.015703043,
0.0024784522,
0.037471637,
-0.015770437,
-0.011106702,
-0.027173677,
0.010028381,
-0.007218008,
-0.01166608,
0.026755828,
-0.012023274,
-0.0168218,
-0.027578047,
0.017832726,
-0.008788312,
0.007076478,
-0.0094420435,
-0.008613085,
0.0006158221,
-0.012488299,
0.02387132,
-0.03175654,
-0.0016713968,
-0.0040369625,
-0.018641466,
0.00028158486,
-0.018385364,
0.018358406,
-0.012980283,
0.013074636,
0.0065305787,
0.004774938,
-0.004154904,
0.0031793606,
-0.02128335,
-0.014328184,
0.04437289,
0.0018904306,
-0.011895223,
0.000108358574,
0.005644334,
-0.019072793,
-0.017199213,
0.0045693833,
0.031540874,
-0.016376993,
0.0067664613,
-0.06394441,
0.023561303,
-0.011376281,
0.017859682,
0.022577336,
-0.01695659,
-0.004434593,
0.0033057262,
-0.00004154272,
0.033805348,
-0.0024076875,
0.008471555,
0.01126171,
-0.011423457,
-0.03038168,
-0.024221774,
0.04059877,
0.0038886934,
0.021202477,
0.02360174,
-0.02291431,
0.003838147,
0.013782284,
0.030058185,
-0.006837226,
-0.016093934,
-0.028144166,
0.005300619,
-0.0021212585,
0.0155008575,
-0.0004269054,
-0.0504654,
-0.023696093,
0.010365356,
-0.009300514,
-0.013128553,
-0.030866925,
0.002141477,
0.024882246,
0.024653103,
-0.0053073587,
-0.054670848,
0.0017943927,
-0.014072083,
0.0037370545,
-0.026176231,
-0.04030223,
0.0011684614,
0.0039223908,
-0.037094224,
0.027766753,
0.008080664,
0.014584285,
-0.03526108,
0.0032063187,
0.019598475,
-0.016525261,
-0.023022143,
-0.015312151,
-0.024733977,
0.008532211,
0.0051927874,
0.026607558,
0.00054842705,
0.011490853,
0.01993545,
-0.022415588,
0.011827828,
-0.016228724,
-0.011652601,
-0.027092803,
0.028575493,
0.010297961,
0.02822504,
0.017617062,
-0.011322365,
-0.026122315,
0.004003265,
-0.036986392,
-0.004636778,
0.0061059897,
-0.0090376735,
-0.0138833765,
0.0023284983,
0.025731424,
-0.006453074,
0.028656367,
0.007716731,
0.0078313025,
0.017913599,
-0.0007859946,
0.025866212,
0.012063711,
0.016619615,
-0.012211979,
0.00041005664,
0.009024194,
-0.019328894,
0.016727448,
0.03162175,
-0.008592866,
0.011760433,
-0.032214824,
-0.01614785,
-0.019827617,
0.027362382,
-0.012548955,
-0.025623592,
0.0024481246,
0.0027968937,
0.008532211,
-0.0045087277,
0.0007889431,
0.012987022,
-0.0041616433,
0.006961907,
0.016053496,
-0.023022143,
0.013458787,
0.042431913,
0.014058604,
0.023615219,
0.017711414,
0.01750923,
-0.00064741354,
0.019854575,
0.023291722,
-0.0022863764,
0.022860395,
-0.026054919,
0.012326552,
-0.035234123,
-0.037229016,
-0.0027210745,
-0.00664852,
0.02291431,
-0.006362091,
0.036177654,
-0.013869897,
0.09095634,
0.005071476,
-0.009489221,
0.006685587,
-0.01763054,
0.035153247,
0.004596341,
0.027119761,
-0.007433672,
-0.03930478,
0.010877558,
-0.0024464396,
0.010055339,
-0.012515257,
-0.01574348,
0.012602871,
-0.010641675,
0.005819561,
0.003322575,
-0.028521577,
-0.00034308282,
-0.035503704,
-0.0017371069,
0.007541504,
-0.027187156,
-0.002859234,
0.03876562,
0.0027311835,
0.004451442,
-0.024990078,
0.004953535,
0.0036932477,
-0.02809025,
-0.0044682906,
0.02321085,
-0.0065002507,
-0.014611243,
0.013546402,
0.014894302,
0.00407066,
-0.0028053182,
0.0001444781,
0.0039426093,
-0.010142952,
0.022550378,
0.0057858634,
-0.011848046,
0.01695659,
-0.003716836
] |
Nitric oxide (NO) was identified as a key player in plant defence responses approximately 20 years ago and a large body of evidence has accumulated since then supporting its role as a signalling molecule. However, there are many discrepancies in current NO detection assays and the enzymatic pathways responsible for its synthesis have yet to be determined. This has provoked strong debates concerning the function of NO in plants, even questioning its existence in planta. Here we gather data obtained using the model pathosystem Arabidopsis/Pseudomonas, which confirms the production of NO during the hypersensitive response and supports is role as a trigger of hypersensitive cell death and | [
-0.033714715,
-0.013817507,
-0.007994414,
-0.011034266,
-0.008849784,
0.028950967,
-0.022594914,
0.007698325,
-0.031530235,
-0.013672752,
0.012902919,
-0.018686533,
-0.010534204,
0.025029426,
-0.010060461,
0.0014582404,
0.036004476,
0.0003435871,
0.0130213555,
0.014936067,
-0.014870269,
0.023858229,
0.0005489992,
-0.01371223,
0.0137648685,
0.019910369,
0.0069811307,
-0.049374558,
-0.010889512,
-0.027029675,
-0.0014541281,
0.0020512417,
-0.012679207,
0.009751212,
-0.00058066426,
-0.019331349,
0.005349349,
-0.010738176,
0.012777904,
0.008652391,
0.01316611,
0.011007947,
-0.004066295,
-0.015422969,
-0.018739171,
-0.01148169,
-0.00953408,
-0.0013784608,
-0.008816885,
0.034951713,
0.020673621,
0.0033162015,
0.007507512,
-0.0129884565,
-0.01429125,
-0.02047623,
0.0039379895,
0.0034872754,
-0.0055796406,
-0.02829299,
-0.010863192,
0.0057572946,
-0.021739544,
0.019976167,
-0.00615866,
-0.0063692126,
0.0056980764,
0.027687652,
-0.01372539,
0.004293297,
0.022186968,
0.039452273,
0.0024624772,
-0.0039774682,
0.01287002,
-0.0069350726,
-0.029740538,
-0.016423093,
-0.019726137,
-0.0019722846,
0.023489762,
-0.016186222,
-0.02046307,
0.031977657,
0.02992477,
-0.0028835821,
0.010152577,
0.026503295,
-0.0036649292,
-0.015330853,
0.019778773,
0.03253036,
0.022226447,
-0.00068141695,
-0.007316699,
0.026766485,
-0.007389076,
0.027213909,
0.0079549365,
-0.022660712,
-0.0048492867,
-0.02942471,
-0.022068532,
-0.0045531974,
-0.008297084,
0.011619865,
0.0022338303,
0.0072443215,
0.010481566,
-0.020989452,
-0.04340013,
0.03863638,
-0.035346497,
-0.040741906,
0.018857608,
-0.008441838,
0.03418846,
0.013277966,
-0.027898204,
-0.007941777,
0.0006452282,
-0.0006892304,
0.037057236,
-0.04179467,
0.024753077,
0.016488891,
0.0074351346,
-0.016357295,
-0.02997741,
0.006208008,
-0.00559938,
0.027003355,
0.004878896,
-0.0024756365,
-0.002969119,
0.02826667,
-0.03331993,
-0.00811943,
-0.0012369958,
-0.040162887,
0.0179496,
0.021726385,
-0.035188586,
0.015896713,
0.005211174,
0.01762061,
0.028345628,
0.025647925,
0.015265055,
0.014185973,
0.0044084424,
-0.012396278,
0.0061751097,
-0.021489512,
0.01063948,
0.026174305,
-0.026266422,
0.020002486,
-0.0051585357,
0.0045762267,
0.018647054,
-0.0036221608,
0.014514962,
-0.0123765385,
0.00784308,
0.020370953,
-0.004345935,
0.002885227,
-0.008283924,
-0.00016233514,
-0.004151832,
0.023292368,
-0.0076654265,
0.028345628,
0.009777531,
0.011744881,
0.018607575,
0.028187715,
0.04674265,
-0.006507388,
0.0015437774,
0.016633647,
0.0065666055,
-0.00279969,
-0.027819246,
-0.0063494733,
0.030951215,
0.0049348236,
0.0141201755,
-0.009777531,
-0.020186719,
0.024989948,
-0.016186222,
-0.014383366,
-0.63418406,
-0.023463443,
-0.01036313,
0.0041386723,
0.03131968,
0.020660462,
-0.0055335825,
-0.004112353,
-0.020173559,
0.025437372,
-0.029029924,
-0.001065922,
-0.00008209285,
-0.013310865,
-0.026727006,
-0.037004597,
-0.004980882,
-0.010389449,
0.025542649,
-0.017910121,
0.00008836419,
-0.027635014,
-0.012462075,
0.0058165123,
-0.0022469899,
0.03247772,
0.017173188,
-0.017896961,
-0.0076259477,
0.037162513,
0.010744756,
-0.00476046,
0.014028059,
0.029793177,
0.049111366,
0.012652888,
-0.0014894943,
0.034267418,
-0.0075272513,
0.030609068,
-0.025147863,
0.001314308,
0.021055248,
-0.0130542535,
-0.006477779,
0.016133584,
0.020305155,
-0.011363254,
-0.008744508,
-0.01931819,
0.018015398,
0.015422969,
-0.01261999,
0.02047623,
0.007310119,
0.02131844,
0.03142496,
-0.025095224,
0.0010141063,
0.0016877097,
-0.024002982,
0.009112975,
-0.018594416,
-0.036030795,
-0.005066419,
0.027898204,
-0.039583866,
0.007507512,
0.014672876,
0.0084089395,
0.013554316,
0.03255668,
-0.010547363,
-0.009909126,
0.011633025,
0.03113545,
0.008461578,
0.01149485,
-0.009876227,
0.030898577,
-0.0062869657,
-0.007152205,
-0.033662077,
0.0096327765,
0.038478468,
0.001387508,
0.0019722846,
0.014343888,
0.0044380515,
-0.015830915,
0.01565984,
0.007612788,
-0.046058357,
-0.019081319,
-0.030477472,
0.018660214,
-0.016988954,
-0.013580635,
-0.013488518,
-0.00037484098,
-0.033188336,
-0.011810678,
-0.01147511,
-0.020976292,
0.0008417987,
0.0090537565,
-0.019397147,
-0.004819678,
0.039557546,
-0.021923777,
0.012962137,
-0.0040103667,
-0.007915458,
-0.023345007,
-0.006277096,
-0.022568595,
0.028766733,
0.0133766625,
0.014422845,
-0.010784235,
-0.010593422,
-0.026516454,
-0.014501803,
-0.019357668,
0.024818875,
0.024753077,
-0.013672752,
-0.03926804,
-0.03342521,
0.0006892304,
-0.002437803,
-0.00039437469,
0.026661208,
0.0035201744,
0.002209156,
-0.008435259,
0.034556925,
0.019436626,
0.014883429,
-0.03216189,
-0.018331226,
-0.011619865,
-0.016449412,
-0.0018883926,
-0.02046307,
-0.006046804,
-0.008718189,
0.018239109,
0.0060402243,
0.009066916,
0.0037438862,
0.0007521494,
-0.012363379,
0.0047801994,
0.004622285,
0.0069811307,
-0.012494974,
-0.00979727,
-0.026858602,
0.011659344,
0.020752579,
0.0050861584,
-0.02129212,
0.0055928,
-0.019081319,
-0.015265055,
0.012508133,
0.011179021,
0.025858477,
-0.043794915,
-0.0021088147,
-0.008560275,
-0.0084089395,
0.017686408,
-0.01202781,
0.008902422,
-0.01985773,
0.0043854136,
-0.011975173,
0.013218748,
0.014475483,
-0.0201604,
-0.015001864,
-0.008619492,
0.017844323,
0.020634143,
0.024621481,
0.03947859,
-0.008086531,
0.04682161,
0.0022190257,
0.008895842,
-0.028924648,
0.022647552,
-0.026687527,
-0.03924172,
0.02383191,
-0.01150143,
0.0014656427,
0.03758362,
-0.004457791,
-0.0071785236,
0.011836997,
-0.018976042,
-0.0058329618,
-0.0001548301,
0.0007579067,
-0.014422845,
0.014028059,
0.013073993,
0.02745078,
0.0044413414,
-0.02130528,
-0.010099939,
0.009915706,
0.012192305,
-0.017567974,
-0.0018949724,
-0.008474737,
-0.025450531,
0.0069811307,
-0.02660857,
0.015422969,
-0.0068758545,
-0.018541778,
0.02213433,
0.014133335,
0.01875233,
-0.01204755,
-0.0034872754,
-0.011573806,
-0.0024164186,
-0.0074088154,
-0.01233706,
0.017199505,
0.011915955,
0.017844323,
-0.009468282,
0.048900813,
0.012284421,
-0.023384485,
-0.003444507,
0.0057540047,
-0.0011818903,
0.014949227,
0.001064277,
0.030030048,
0.00979727,
-0.039978653,
0.00727064,
-0.007421975,
0.020291995,
-0.010067041,
-0.023555558,
0.0035300439,
-0.007764123,
0.009468282,
0.01065922,
0.05066419,
0.01454128,
0.034556925,
-0.0038129739,
0.02437145,
-0.014620238,
0.003107294,
-0.0026812542,
0.010803974,
0.004822968,
-0.0025085355,
-0.0019410307,
-0.012968717,
0.0093432665,
0.0018587837,
0.002044662,
0.01540981,
0.0012592026,
-0.0022914032,
-0.0050072013,
0.009744632,
-0.006329734,
-0.0023275919,
-0.00060328224,
0.034793798,
0.007698325,
-0.011705402,
-0.026437497,
-0.015422969,
0.014949227,
-0.006076413,
0.0070206095,
-0.012277842,
0.020055125,
-0.003786655,
0.0056224093,
0.0130213555,
-0.020357793,
0.0064284303,
-0.013185849,
0.029608943,
-0.0065929247,
-0.0049381135,
-0.0033013972,
-0.006777158,
-0.017686408,
0.038294233,
-0.0046354444,
0.010619741,
-0.008237866,
0.0017337681,
-0.010323651,
0.022015894,
0.008764247,
0.0011012881,
-0.028687775,
-0.0018933275,
0.020542027,
0.0006464619,
0.009251149,
0.034530606,
-0.000707736,
-0.0058987592,
-0.03753098,
0.0071587847,
-0.0025036007,
0.03505699,
0.0084089395,
0.0053921174,
0.025634766,
-0.017844323,
-0.0014681101,
-0.016738923,
-0.008586594,
0.020186719,
-0.036530856,
-0.0042834273,
-0.0031895412,
0.02212117,
0.008204967,
0.004674923,
0.004151832,
0.00004317971,
0.0028210743,
-0.01987089,
0.0073627573,
-0.0022914032,
-0.011060585,
0.0029477347,
0.027292866,
0.030214282,
0.0032981073,
0.0083892,
0.016383614,
0.025174182,
0.006362633,
0.028108757,
0.027661333,
0.0024608322,
-0.0045531974,
-0.035372816,
-0.012738425,
0.0022206707,
0.024555683,
0.009264309,
0.0055105533,
0.0120541295,
0.009968344,
-0.0017716017,
-0.00023234796,
-0.031188086,
-0.030714344,
0.01119876,
0.024437247,
-0.013817507,
-0.0038985107,
0.0179496,
-0.020278836,
-0.0029214157,
-0.031556554,
0.02689808,
0.002603942,
0.0075535704,
0.0068297964,
0.004345935,
0.018673373,
-0.009652516,
-0.0012624924,
0.038767975,
-0.030635387,
0.003559653,
-0.0069482317,
-0.00044865772,
-0.01202781,
-0.031030172,
0.01430441,
0.01796276,
-0.0021598078,
-0.038794294,
0.018541778,
0.053585608,
0.010468407,
0.004461081,
-0.016409934,
-0.014475483,
0.01904184,
-0.019673498,
-0.026240103,
-0.010271014,
-0.031240724,
0.0011596836,
0.01430441,
0.014909748,
-0.011646184,
-0.0109882075,
-0.0056553083,
0.0039840476,
-0.032135572,
0.018028557,
-0.005668468,
-0.004181441,
0.0012082093,
0.011521169,
0.03674141,
-0.003862322,
-0.0017880512,
-0.023555558,
-0.015291374,
0.000491015,
-0.028687775,
-0.003954439,
-0.028450904,
0.0129884565,
0.022687031,
0.01150143,
0.000826583,
0.01877865,
0.0045466176,
0.014185973,
-0.014159654,
0.012679207,
0.0065271268,
-0.014317569,
0.042057857,
-0.011626445,
-0.0053098705,
-0.011692243,
0.012837121,
0.025832158,
-0.006214588,
-0.00030534223,
0.018673373,
-0.0027486968,
-0.013646433,
-0.028161395,
0.014988705,
-0.015080822,
0.007152205,
0.022897583,
-0.019252393,
-0.012981877,
-0.0008422099,
0.010317071,
-0.0020068283,
-0.0067311,
-0.03889957,
-0.0131200515,
-0.004336065,
0.01065264,
0.002771726,
0.049058728,
-0.023279209,
-0.024950469,
0.0111856,
-0.006586345,
0.00007170916,
-0.03389895,
-0.013751709,
-0.036320303,
0.012165986,
-0.009395905,
-0.04505823,
-0.023660835,
-0.013205589,
0.02945103,
0.01796276,
0.013383242,
-0.018607575,
0.020936813,
0.0140543785,
-0.00672123,
-0.004007077,
-0.014028059,
-0.0003378298,
-0.027082313,
0.032635637,
0.01712055,
0.00951434,
-0.008369462,
-0.013041095,
0.0006110957,
-0.0012485104,
-0.0069942903,
-0.008830044,
-0.023134453,
-0.018397024,
-0.00078833813,
0.02069994,
-0.0201604,
0.01593619,
-0.028898329,
0.0020331475,
0.019989327,
0.010560523,
0.0137648685,
-0.021200003,
0.0128766,
-0.018528618,
0.028056119,
0.0046255747,
0.022305403,
-0.02716127,
-0.01880497,
-0.0004922487,
0.0083892,
-0.013146371,
-0.0021746124,
-0.0055335825,
0.016041467,
-0.007145625,
0.0015084111,
0.011942274,
-0.022094851,
-0.016488891,
0.018515458,
-0.015791437,
-0.01569932,
0.004454501,
-0.0034050285,
-0.01344246,
0.0030053076,
0.0069350726,
-0.0023374616,
-0.0044413414,
-0.06274464,
-0.016015148,
0.027792927,
0.002352266,
0.035820242,
0.00154131,
0.025147863,
0.01203439,
-0.014896588,
-0.020923654,
0.007961515,
-0.010836873,
-0.0020907205,
0.033714715,
-0.0050104912,
-0.013606954,
-0.022029053,
0.009770951,
0.025529489,
-0.0009762726,
-0.00980385,
0.04932192,
0.004947983,
0.010014403,
-0.013856986,
-0.01035655,
-0.01149485,
0.010961888,
-0.0051585357,
-0.018094353,
-0.0077180644,
-0.010152577,
-0.021779023,
0.0005876553,
0.011363254,
0.032819867,
0.012396278,
-0.011975173,
-0.017041592,
-0.015738798,
0.0012962137,
0.00021240304,
-0.011929114,
0.021134205,
0.0028654877,
0.017725887,
0.008066792,
0.022713348,
0.012264682,
0.00757331,
-0.004253818,
0.032372445,
-0.004174861,
-0.009652516,
0.024437247,
-0.0061849793,
0.017502176,
-0.029372072,
-0.0030661705,
-0.049164005,
-0.02154215,
-0.008441838,
0.03218821,
0.013205589,
-0.005905339,
-0.005286841,
-0.016107265,
-0.029187838,
-0.010251274,
-0.0009121199,
-0.015449288,
-0.010238115,
-0.019133957,
0.0035761024,
-0.01514662,
0.020765739,
-0.019818252,
-0.022700189,
-0.0028506832,
0.02467412,
-0.010198636,
0.004790069,
-0.011711982,
-0.000580253,
-0.011534329,
0.0030102425,
0.002268374,
-0.028398266,
0.026766485,
-0.0074877725,
-0.03221453,
0.0032635634,
-0.0033260712,
-0.0054217265,
0.009468282,
-0.0034050285,
0.018844448,
0.022923902,
0.0017419928,
0.00616524,
-0.005944818,
0.026832283,
-0.022226447,
0.019791933,
0.022502797,
-0.03634662,
-0.026950717,
-0.004618995,
-0.024489885,
0.007619368,
-0.0031994109,
-0.043373812,
-0.05653334,
-0.013830666,
-0.011146122,
-0.029029924,
0.0062869657,
-0.0046354444,
-0.025990073,
-0.0012304161,
0.018160151,
0.007395656,
-0.0024460277,
0.012356799,
0.009915706,
-0.02048939,
-0.023608197,
-0.0010733242,
0.0043229056,
-0.0342411,
-0.020041965,
-0.011560648,
-0.0068232166,
0.03076698,
0.011540908,
-0.012764744,
-0.021818502,
0.004461081,
-0.04139988,
-0.04590044,
-0.03029324,
0.0042439485,
0.0054973937,
0.027371822,
0.007803601,
0.000019019633,
-0.018028557,
0.005441466,
-0.017975919,
-0.025055746,
0.016844198,
-0.01121192,
0.04226841,
-0.00059670245,
-0.034267418,
-0.016831039,
0.019120798,
-0.03508331,
-0.008507636,
0.012501554,
-0.0012065645,
0.009455122,
-0.0024739916,
0.017423218,
0.0048854756,
0.011047426,
0.025305776,
-0.020844696,
-0.020792058,
0.0016186222,
-0.0015067662,
-0.013909623,
0.0020282126,
0.016330978,
0.020673621,
-0.00015986773,
-0.006862695,
-0.036794048,
-0.0028753574,
-0.011231659,
0.0041682813,
0.035425454,
-0.035767604,
0.0077180644,
-0.0020380823,
-0.0027569216,
-0.0089879595,
-0.014646557,
-0.010106519,
0.019449785,
0.011323776,
-0.011869896,
-0.011547488,
-0.0076391073,
0.0056224093,
-0.03634662,
-0.00054324185,
-0.008481317,
0.020331474,
-0.015541405,
0.022068532,
0.01709423,
0.009942025,
0.0057342653,
0.016896836,
-0.018699693,
-0.011547488,
-0.01371223,
-0.002633551,
0.0045137187,
-0.013699071,
-0.0084089395,
0.0020973,
0.0025907825,
0.0017403478,
-0.0035201744,
-0.023318687,
0.0032027008,
0.1851809,
-0.0075140917,
0.013501678,
0.017699568,
0.003865612,
0.0060336445,
0.0044939797,
-0.015238736,
-0.0046979524,
-0.018831288,
0.009060336,
0.011317196,
-0.013034515,
0.0011580386,
0.010172317,
-0.018923404,
-0.00051774527,
-0.012771324,
-0.00672781,
0.010330231,
0.010527624,
-0.028819371,
0.010336811,
-0.010685539,
0.035714965,
0.0039083804,
-0.01592303,
-0.001151459,
0.036057115,
0.009185352,
-0.01901552,
0.00756015,
0.01987089,
0.013620114,
0.039847057,
0.0043525146,
-0.007533831,
-0.015975669,
0.027213909,
-0.0035892618,
0.00042891843,
0.0116659235,
-0.0063396036,
0.007540411,
-0.009330107,
0.010850033,
-0.0074417144,
-0.010251274,
-0.037688896,
0.010297332,
-0.048348114,
-0.00008358358,
-0.0037373067,
0.008251025,
0.02130528,
0.00010908017,
-0.0062211677,
-0.016620487,
-0.024226695,
-0.0006065721,
-0.019712977,
0.0102775935,
-0.001819305,
-0.0062672263,
-0.022805465,
0.016146744,
-0.036320303,
0.0012978587,
0.0018801679,
-0.0111856,
-0.013685911,
-0.015594043,
-0.011685663,
-0.005717816,
-0.025437372,
-0.015238736,
0.0045531974,
0.011113224,
-0.0010897736,
0.014909748,
0.012225203,
0.007389076,
-0.043531727,
0.0014936067,
-0.01454128,
-0.024792556,
0.0009441963,
0.012001491,
-0.01764693,
-0.009639356,
0.0073298584,
-0.0030332718,
-0.032846186,
-0.015015024,
-0.0014894943,
-0.004872316,
0.017028432,
0.02044991,
-0.007079827,
0.0022321853,
-0.012014651,
0.07853608,
0.00053378346,
0.017752206,
-0.014317569,
0.031188086,
-0.0043590944,
0.022292243,
-0.013080573,
-0.0015594043,
-0.002357201,
-0.00923799,
0.0071258857,
-0.0099551845,
-0.017186346,
0.0162915,
0.009501181,
-0.017818004,
0.019002361,
-0.032583,
0.0053131604,
0.0054513356,
-0.0050894483,
0.040215526,
-0.019449785,
-0.0008487897,
-0.034030546,
0.020528868,
-0.0076654265,
-0.032898825,
-0.008948481,
0.0010470052,
0.0043294854,
0.019910369,
0.01712055,
-0.0024032593,
0.015225576,
0.00839578,
-0.0089879595,
0.011257978,
0.000095252384,
-0.01764693,
0.0024016143,
0.018265428,
0.011396153,
0.0012698947,
0.03050379,
0.0002631906,
0.0039379895,
-0.0016013504,
0.00056051376,
-0.008093111,
-0.017041592,
-0.008007574,
0.010448667,
-0.019173436,
-0.019726137,
-0.025121544,
0.0003199411,
0.006474489,
-0.015765117,
0.007889139,
0.014146495,
-0.01593619,
-0.0021910619,
0.023897707,
-0.16465203,
0.024766237,
0.027898204,
-0.01626518,
0.048348114,
-0.0022338303,
-0.0015174584,
0.004615705,
0.009586718,
0.019818252,
0.03608343,
-0.006283676,
-0.010744756,
-0.039162762,
0.015172938,
0.02634538,
0.0035530732,
0.032977782,
0.00952092,
0.026121667,
0.006750839,
-0.0054941038,
0.012718686,
-0.02884569,
-0.002154873,
0.013988581,
0.009935445,
-0.00070033374,
-0.0140543785,
-0.006352763,
-0.018252268,
-0.0049677226,
0.0006135631,
0.0068297964,
0.034583244,
-0.0042110495,
-0.00035448486,
-0.028319309,
-0.014488643,
0.03029324,
0.017502176,
-0.0014409686,
-0.009494601,
-0.01846282,
-0.038531106,
0.008882683,
0.020910494,
0.0005868328,
0.014593919,
-0.025832158,
0.031267043,
-0.0048657362,
-0.0032059907,
0.027055994,
0.00923799,
0.018936563,
-0.021489512,
0.020568347,
-0.00046798578,
-0.006273806,
0.00095653336,
-0.0072969594,
0.0017387029,
0.012488394,
-0.0069416524,
-0.0047012423,
-0.0026006522,
0.0032964624,
-0.036583494,
0.008770827,
-0.005092738,
-0.026292741,
0.020884175,
-0.01880497,
0.016659966,
-0.0039116703,
-0.010711858,
-0.002855618,
-0.008422099,
0.033293612,
0.016475732,
0.012856861,
-0.009948605,
-0.028135076,
-0.005059839,
-0.007461454,
0.00029896808,
0.024529364,
0.0037702054,
0.00896164,
0.010817134,
-0.022910742,
-0.0016556334,
-0.03505699,
0.019712977,
0.0042110495,
0.012784484,
-0.002378585,
0.00022268393,
-0.009613037,
0.013514837,
-0.0019163566,
0.0020561765,
0.01875233,
0.010626321,
0.0201604,
-0.011119803,
-0.013060833,
0.043715958,
-0.01346878,
0.0076391073,
-0.009152453,
0.005063129,
0.042347368,
-0.030030048,
0.02437145,
0.024002982,
-0.014370207,
-0.0040926137,
-0.025792679,
0.048558667,
0.0144096855,
-0.006191559,
0.0062244576,
-0.010007823,
-0.044663444,
-0.12822646,
-0.020015646,
-0.0013603665,
0.01846282,
-0.0068232166,
0.010856613,
0.006356053,
0.03897853,
0.0059612673,
0.022739667,
0.0027125082,
0.007731224,
-0.0062277475,
-0.0034412171,
0.02046307,
0.01710739,
-0.017699568,
-0.019528743,
-0.021436874,
0.02522682,
-0.01346878,
-0.026292741,
0.013396402,
-0.0093103675,
0.020831537,
-0.011014527,
-0.0011457016,
0.017791685,
-0.00070732477,
0.0001385863,
0.019305032,
-0.009619617,
0.019739294,
-0.029503666,
-0.008639231,
0.013501678,
0.016659966,
-0.012429176,
0.025029426,
-0.00088662334,
0.0018867477,
0.0025068906,
0.01906816,
-0.022055373,
0.02408194,
-0.028793052,
0.0034148982,
0.010777655,
-0.008303664,
-0.018818129,
-0.039346997,
-0.013606954,
-0.032346126,
-0.0113106165,
0.027950842,
-0.005546742,
0.014449164,
0.03863638,
-0.029793177,
0.0036090012,
-0.0079549365,
0.010040722,
-0.0067574186,
-0.014922908,
0.0033754194,
-0.0280298,
-0.028635139,
-0.03845215,
0.034109503,
-0.015909873,
-0.014896588,
0.0014533056,
0.015817756,
-0.0077114846,
-0.011909375,
0.017002113,
-0.016344136,
-0.016607327,
-0.0029444448,
-0.01540981,
-0.0047834893,
-0.023858229,
0.006053384,
-0.001106223,
0.023397645,
0.013909623,
0.0014088922,
0.0042801374,
0.014975545,
-0.007336438,
-0.039004847,
0.01540981,
-0.004648604,
0.0037899448,
-0.00062219903,
0.012850281,
0.014159654,
0.00616524,
0.040347118,
-0.004184731,
-0.021094726,
-0.030477472,
-0.043558046,
0.020384112,
0.00082370435,
0.003500435,
-0.0039675985,
-0.00018505589,
0.009461702,
0.017054752,
0.019844571,
0.0141201755,
-0.036320303,
-0.010961888,
-0.00839578,
-0.0055039735,
-0.017594293,
-0.041689392,
0.037952084,
-0.0072443215,
0.032898825,
0.0050466796,
-0.004415022,
0.0014500157,
0.019752454,
0.018844448,
-0.0062968354,
-0.017002113,
-0.023094976,
-0.021344759,
-0.02043675,
-0.0065731853,
0.0050894483,
-0.039557546,
-0.000566271,
-0.00011823016,
-0.008060212,
-0.013856986,
-0.033662077,
0.024950469,
-0.002577623,
0.018581256,
-0.02992477,
-0.033109378,
0.005072999,
-0.01485711,
-0.0055335825,
-0.006359343,
-0.02884569,
0.0093103675,
0.0072377417,
-0.018818129,
0.039320678,
0.0076654265,
-0.031451277,
-0.02323973,
-0.028450904,
-0.0036813787,
0.007389076,
-0.0029576044,
0.010106519,
-0.03929436,
0.03524122,
0.026687527,
0.02860882,
0.010856613,
0.0060731233,
-0.004648604,
-0.02155531,
-0.00073405507,
0.024687279,
0.0075930487,
-0.03505699,
-0.018423343,
0.0077114846,
0.005398697,
0.013817507,
0.018660214,
-0.02296338,
-0.00096393557,
-0.0062343273,
0.012896339,
0.0038853514,
0.0007718887,
-0.017765366,
0.030003728,
0.023516081,
-0.0054217265,
-0.013659593,
0.018068034,
-0.0000021429216,
-0.0062573566,
-0.011363254,
0.0022321853,
-0.0042439485,
0.007619368,
0.005905339,
0.019383987,
0.0011465241,
0.012100188,
-0.0034839856,
0.026490135,
-0.00043015214,
0.01987089,
0.009205092,
-0.02908256,
0.0016737278,
0.01652837,
-0.02631906,
-0.0069021736,
-0.01906816,
0.0026450655,
-0.017396899,
-0.008948481,
0.008718189,
0.0059875865,
-0.014370207,
0.013949102,
-0.0007661314,
0.0018045006,
-0.008152329,
0.02130528,
0.03274091,
0.0060073254,
0.016317818,
0.000395814,
0.0015635167,
-0.004063005,
0.032056615,
-0.019397147,
0.026147986,
-0.021121046,
0.008836624,
-0.0017716017,
-0.026398018,
-0.013073993,
0.0054710745,
-0.016357295,
0.03839951,
0.030056367,
0.007704905,
0.079694115,
0.0008360414,
-0.009849909,
-0.011514589,
0.0025661085,
0.018146992,
-0.017317941,
0.0069021736,
0.0018242399,
-0.03276723,
0.013330604,
0.008856364,
0.02887201,
-0.008270765,
-0.017133709,
0.009119554,
-0.010409188,
-0.001511701,
-0.009205092,
-0.0070271892,
0.03782049,
-0.015567725,
0.010159157,
0.029529985,
-0.014580759,
-0.008441838,
0.036241345,
-0.03113545,
0.0038919311,
-0.014185973,
-0.008060212,
0.0045564873,
-0.021436874,
-0.0010322006,
-0.008843204,
0.0090537565,
-0.0011810678,
-0.0036287406,
0.012383118,
0.0019344509,
-0.00896822,
0.034793798,
-0.023858229,
-0.020528868,
-0.001962415,
0.0049446933,
-0.018252268,
0.002858908,
-0.018818129
] |
The molecular chaperone CCT/TRiC plays a central role in maintaining cellular proteostasis as it mediates the folding of the major cytoskeletal proteins tubulins and actins. CCT/TRiC is also involved in the oncoprotein cyclin E, the Von Hippel-Lindau tumour suppressor protein, cyclin B and p21(ras) folding which strongly suggests that it is involved in cell proliferation and tumor genesis. To assess the involvement of CCT/TRiC in tumor genesis, we quantified its expression levels and activity in 18 cancer, one non-cancer human cell lines and a non | [
-0.025250738,
-0.01830309,
0.0047101565,
-0.029403202,
0.0013438392,
0.019458791,
-0.007915213,
0.0052947267,
0.0013866741,
0.007095471,
0.014069997,
-0.0038433801,
0.037761882,
0.014728478,
0.0017755475,
0.019861944,
0.016112633,
-0.006927491,
-0.01420438,
0.008714797,
-0.025949536,
0.01830309,
-0.01889438,
-0.01562885,
-0.0078009865,
0.004538817,
0.014150627,
-0.0376275,
-0.000005918667,
-0.037815634,
0.0045119403,
0.004454827,
-0.013881859,
-0.016233578,
0.0037896265,
-0.00936656,
0.037493113,
-0.0007386916,
0.021823948,
-0.0058289026,
0.0391326,
0.024955094,
-0.006319404,
0.0030404362,
-0.0013522382,
0.014997246,
0.019324409,
-0.0039844834,
-0.017684923,
0.0106163295,
-0.0028892544,
0.024417559,
-0.0057516317,
-0.016771113,
-0.0024625855,
-0.014069997,
-0.0036418042,
0.019270655,
0.006561295,
-0.0039408086,
0.00055223395,
-0.019539421,
-0.017228018,
0.012269252,
0.020574179,
0.0037392327,
0.00944719,
0.014365641,
0.018773435,
0.016609853,
0.04614744,
0.0316071,
-0.00234164,
-0.008089912,
0.020345725,
-0.031203946,
-0.03786939,
-0.0015302969,
-0.016945813,
0.016596414,
-0.004565694,
-0.001453866,
0.0048008654,
0.008795428,
0.011516702,
0.0028707765,
-0.0015529742,
0.002224054,
0.0028438997,
0.006420192,
0.027293375,
0.02397409,
0.004202857,
0.021299852,
-0.025129793,
0.016972689,
-0.007364239,
0.030881425,
-0.020762315,
-0.014688163,
-0.0029950817,
0.00026960776,
-0.008083193,
-0.021716442,
-0.02808624,
-0.008889496,
0.027387444,
-0.010119109,
0.01880031,
-0.018316528,
-0.027387444,
0.02717243,
-0.021246098,
-0.036659934,
0.017953692,
-0.0048445403,
0.029591339,
0.019458791,
0.0011918175,
-0.019835066,
0.009292648,
0.019270655,
0.023100596,
-0.00096504454,
0.041444,
0.012047519,
-0.00027548705,
0.0036653215,
0.006252212,
-0.00894325,
-0.008963408,
0.009474066,
0.0044178716,
0.015413836,
-0.012672404,
-0.009547978,
-0.006006961,
-0.005214096,
-0.0075590955,
-0.019929135,
0.0060976706,
0.04069145,
-0.017563978,
-0.01654266,
0.0018393799,
0.005644125,
0.005657563,
0.014446272,
-0.007827863,
0.012894137,
0.015239136,
-0.0049621263,
0.011960169,
0.0050763525,
-0.0055870116,
0.014002805,
-0.0006106069,
-0.00071013503,
-0.0089701265,
-0.034778558,
-0.0045152996,
-0.00050519954,
0.0195663,
0.0038500994,
0.026231742,
0.028139994,
0.017066758,
0.0042834873,
0.014392518,
0.0096756425,
0.011006043,
0.026527386,
-0.022872144,
0.01980819,
-0.042734087,
-0.0066251275,
0.013048679,
0.014190942,
-0.04679248,
-0.015736356,
-0.031311452,
0.02324842,
0.0106297685,
-0.0065176203,
-0.011966888,
-0.012907576,
0.018397158,
0.003527578,
0.0010565936,
-0.035719246,
-0.0063160444,
0.0063933153,
0.012753034,
-0.004612728,
-0.63085186,
-0.019284092,
0.010911974,
-0.021823948,
-0.006537778,
0.018195583,
0.027683089,
0.0040281583,
-0.045153,
0.01579011,
-0.011241215,
0.019203462,
-0.004814304,
-0.029188188,
-0.019458791,
-0.0580001,
-0.028677529,
-0.013854982,
0.025358247,
-0.002482743,
-0.020923577,
0.002749831,
-0.017994007,
0.011993765,
-0.00072357344,
0.025237301,
0.047276262,
-0.021716442,
0.013035241,
0.03034389,
-0.009171703,
0.025613576,
-0.020117274,
-0.008634167,
0.043164115,
0.018692803,
0.0068401415,
0.009682362,
0.012860541,
0.037761882,
-0.0025129793,
-0.008775271,
0.028596899,
0.002131665,
-0.025546383,
0.031150194,
0.008654324,
-0.016703922,
-0.00994441,
0.005526539,
0.010481946,
0.0026927178,
-0.024672888,
-0.01320994,
-0.003826582,
-0.007848021,
0.037331853,
-0.037089963,
0.014620971,
0.005224175,
-0.015158506,
0.01378779,
0.0014085114,
-0.03201025,
-0.0139356125,
0.017093634,
-0.012880699,
0.017429594,
0.00175539,
0.026379563,
0.0139356125,
0.015454151,
-0.0037224346,
0.008781989,
0.00835868,
0.03158022,
-0.010549138,
0.010414754,
0.012941171,
0.029053804,
0.014903177,
-0.00039685253,
-0.014943492,
-0.010495384,
-0.004377556,
0.009870499,
-0.01412375,
0.027978733,
0.010414754,
0.022052402,
0.004522019,
-0.010287089,
-0.0028455795,
-0.025344808,
-0.008566975,
0.02507604,
0.0007798467,
0.018128391,
0.0024760237,
-0.04163214,
-0.010273651,
-0.021608934,
0.00911123,
0.0023198025,
-0.004713516,
0.010885098,
-0.023920339,
0.012101272,
0.044534832,
-0.014930054,
0.0019351285,
-0.0115704555,
-0.0032991252,
-0.02683647,
0.006057355,
-0.024780395,
0.008573694,
0.026097357,
-0.009433751,
-0.03233277,
-0.010905256,
-0.0067830286,
0.012705999,
-0.00023391201,
0.015333205,
0.01529289,
0.025546383,
-0.0084863445,
-0.0022358126,
-0.011422633,
0.008036159,
-0.0038467397,
0.027602458,
-0.035074204,
0.039589502,
0.005970006,
0.013250255,
0.00065806124,
-0.013223378,
-0.034052886,
-0.021823948,
-0.014553779,
0.003210096,
0.00710219,
-0.0192169,
-0.026312372,
-0.021272974,
0.0008676162,
0.0005509741,
0.019015325,
0.00038425403,
0.0063529997,
-0.0065881717,
0.0011876179,
0.010374439,
-0.021367043,
-0.023167789,
-0.035907384,
-0.008472906,
-0.051092766,
0.007747233,
0.000016430535,
-0.023019966,
0.014715039,
-0.00097176374,
0.0070349984,
0.011402476,
-0.016099194,
-0.0039844834,
-0.028193748,
0.0008050437,
-0.027978733,
-0.034966696,
0.017201142,
-0.012571616,
0.025747959,
0.013223378,
-0.011879539,
-0.000610187,
-0.0051435446,
-0.009104511,
-0.011321845,
-0.020748878,
-0.010119109,
0.023423117,
0.018195583,
0.014728478,
0.0057146763,
0.007229855,
0.02424286,
-0.022294292,
0.0077203563,
-0.0026053684,
0.018612172,
0.009212018,
-0.02773684,
0.016032001,
0.020789193,
0.005106589,
0.012235656,
0.020789193,
-0.019956013,
0.029053804,
-0.021286413,
-0.001453866,
-0.0074515883,
-0.0072096973,
-0.012464109,
0.018907817,
-0.0038165033,
0.0050528357,
0.010098952,
-0.009292648,
0.0033176031,
0.0013866741,
0.022227101,
-0.011180743,
-0.00785474,
-0.002983323,
-0.032628417,
-0.0018192224,
-0.0031311454,
0.017402718,
-0.007223136,
0.0038165033,
0.018034322,
-0.0040751924,
0.015601973,
-0.018921256,
0.008237734,
-0.00785474,
0.0134787075,
0.009998164,
0.014110312,
-0.004663122,
-0.0006677201,
0.008197419,
-0.010213178,
0.050635863,
-0.009810027,
0.0018561779,
0.016529223,
-0.004686639,
-0.007411273,
0.0013681963,
-0.007747233,
0.008701359,
-0.010992605,
0.01613951,
0.014809108,
-0.0070685945,
0.028193748,
-0.025089478,
-0.006141345,
0.0025264178,
-0.0024525067,
0.0071828207,
0.029645093,
0.064128004,
0.006218616,
0.0040281583,
-0.0009684041,
0.02414879,
-0.0044917827,
-0.004286847,
-0.007915213,
0.021931456,
-0.0064067533,
-0.017873062,
0.004088631,
0.011610771,
0.007370958,
0.004202857,
-0.028489392,
0.023275295,
0.015386959,
0.010623049,
0.010475227,
-0.017658047,
0.01170484,
-0.008580414,
-0.04472297,
0.027064921,
0.020291973,
-0.018867502,
-0.0013547579,
-0.02039948,
-0.008661044,
-0.0023970732,
-0.0031731403,
-0.002907732,
0.0018964931,
0.011577175,
0.0062656505,
-0.006561295,
-0.022374922,
-0.0025516148,
-0.025398562,
0.012564897,
-0.011234496,
-0.005005801,
0.00028724564,
-0.014137189,
0.0148763005,
0.019445354,
0.0094673475,
-0.018061198,
0.018854065,
-0.025062602,
-0.027763719,
0.013895297,
-0.020076958,
0.009023881,
-0.014580656,
-0.0000488979,
0.00084031944,
0.028139994,
-0.010085513,
0.012423794,
0.006920772,
-0.013471988,
-0.01145623,
-0.021891141,
-0.0003895034,
0.026957415,
0.033891626,
-0.012665684,
0.010891817,
0.0053854357,
0.025344808,
0.003826582,
-0.041444,
0.028032485,
-0.033864748,
0.0027447916,
-0.028543144,
-0.0139087355,
0.00760613,
0.009104511,
0.03158022,
-0.0030454756,
-0.004740393,
0.0041020694,
0.0060741534,
0.023208104,
-0.013149466,
0.009299368,
0.032628417,
0.04087959,
-0.01906908,
0.010670084,
0.035342973,
-0.00069333706,
-0.001780587,
-0.0023802752,
0.011731717,
0.005358559,
0.014835985,
-0.021487989,
-0.03953575,
-0.0029967614,
0.020762315,
0.015373521,
0.016193263,
0.021850826,
0.009413593,
-0.005089791,
-0.0040180795,
0.007747233,
-0.009521101,
0.0072701704,
0.003937449,
-0.00047034372,
-0.0024810631,
0.032144636,
0.011409195,
-0.008419152,
-0.0072164168,
-0.0038433801,
-0.023100596,
-0.0020073599,
-0.0045858514,
0.013129309,
-0.017093634,
-0.01211471,
-0.02733369,
-0.0019788032,
-0.010072075,
0.026272057,
-0.0023533984,
-0.0053048055,
-0.026285496,
-0.010999324,
0.0031580222,
-0.0070349984,
-0.04579804,
-0.030800795,
0.007028279,
0.007404554,
0.011839223,
0.012988206,
-0.026231742,
-0.00208967,
-0.0014975409,
-0.0058624987,
-0.0120407995,
0.001965365,
-0.043755405,
-0.0054223915,
-0.0162067,
0.02816687,
-0.018410597,
-0.0068334225,
0.004797506,
0.0030975493,
-0.026863346,
0.017375842,
-0.015118191,
0.0019183304,
0.009749553,
0.018988447,
0.018370282,
0.0056676418,
-0.00097596325,
-0.0035712528,
-0.023947215,
-0.005489583,
-0.00551646,
-0.008963408,
-0.017926816,
-0.00468328,
0.019929135,
-0.0050360374,
-0.01990226,
0.01103292,
0.005133466,
-0.014849423,
-0.001303524,
-0.013304008,
0.019176586,
-0.027709965,
-0.0012212138,
-0.0012867261,
-0.019324409,
-0.025049163,
-0.007256732,
0.028381884,
-0.017859623,
-0.01905564,
0.00014803228,
0.002104788,
-0.013021802,
0.0048378212,
-0.003201697,
-0.010461789,
0.046604343,
0.00035926703,
-0.018598735,
-0.019794751,
-0.013364481,
-0.012591774,
0.000092231465,
-0.0002792666,
-0.012168464,
-0.02097733,
0.005889375,
0.0075523765,
-0.0017570697,
-0.0007790068,
-0.033542227,
-0.015225698,
0.010152705,
0.0046597626,
0.01144951,
0.017322088,
0.0020123993,
-0.032950938,
-0.0069946833,
-0.017604293,
-0.058161363,
-0.001429509,
-0.0015479348,
0.036794316,
0.019015325,
0.04429294,
-0.001471504,
-0.0042566108,
0.018921256,
0.02048011,
-0.002632245,
-0.014822546,
0.012793349,
-0.017805869,
0.01570948,
-0.006531059,
-0.008761832,
0.028946297,
-0.01177875,
0.0005484544,
0.018692803,
-0.0055534155,
-0.026675208,
0.026527386,
-0.028892543,
-0.047921307,
0.016677044,
-0.01052898,
-0.009984725,
-0.01923034,
-0.00034582862,
0.024014406,
0.009433751,
0.017013004,
0.006168222,
0.02039948,
-0.011180743,
0.025291054,
-0.015521343,
0.0037997053,
0.0027951857,
-0.039562628,
0.0034536668,
-0.014580656,
0.02306028,
-0.0064000343,
0.023933776,
0.0040819114,
-0.022092717,
-0.008459467,
0.0153466435,
-0.009453909,
-0.018464351,
0.008204139,
-0.008419152,
-0.015319767,
-0.017658047,
-0.028785037,
-0.042492196,
0.0038668974,
0.017698362,
-0.029886983,
0.023167789,
0.0065948907,
0.005452628,
0.029645093,
0.0013925534,
0.038675692,
-0.014607532,
0.026393002,
0.01019974,
-0.0017738678,
-0.013653407,
-0.021017645,
-0.0054022335,
0.010979166,
0.033219706,
0.03644492,
0.019364724,
-0.004713516,
-0.007491904,
0.009232176,
-0.02291246,
-0.025868906,
0.0004363278,
0.011355441,
0.016690483,
-0.015158506,
-0.010972447,
-0.0030622736,
0.007780829,
-0.0024373883,
-0.0011565416,
-0.0058457004,
-0.02273776,
-0.0056374054,
0.0053081647,
-0.019109394,
0.01929753,
0.0048176637,
-0.005697878,
0.009292648,
-0.025035724,
0.02365157,
-0.003887055,
-0.012390197,
0.016972689,
-0.002901013,
-0.00085039827,
0.01044835,
0.002306364,
0.002901013,
-0.016085755,
-0.012047519,
0.043621022,
0.009198579,
-0.00089869247,
0.0033948738,
0.0061379857,
0.011274811,
-0.023436556,
0.023208104,
-0.02048011,
-0.044749845,
-0.010374439,
0.024672888,
0.0041423845,
-0.024135353,
0.00031160272,
0.00036157673,
0.0036317254,
-0.028623775,
-0.010992605,
0.002383635,
-0.053887952,
-0.025425438,
0.0056743613,
0.037089963,
0.025761398,
-0.0069476487,
-0.016596414,
-0.016354524,
0.03308532,
-0.029322572,
0.017926816,
-0.005617248,
-0.006295887,
-0.034026008,
0.0064067533,
-0.013048679,
-0.028516268,
0.010576014,
-0.008949969,
-0.026608016,
-0.0040281583,
-0.0043909946,
0.030209506,
0.016314209,
-0.034993574,
0.0057986663,
0.0055870116,
0.020265095,
0.013189781,
-0.0108515015,
0.009131388,
-0.03184899,
0.0065075415,
0.009158264,
-0.022764636,
-0.012443951,
-0.0054022335,
-0.014741916,
-0.0032705688,
-0.013485426,
0.0049050134,
-0.014553779,
-0.00660497,
-0.015454151,
0.0036888386,
0.017013004,
-0.01628733,
-0.00585242,
-0.004337241,
-0.0035779718,
0.0059464886,
-0.010999324,
-0.011940012,
-0.0022559701,
-0.010797748,
-0.026540825,
0.010710399,
-0.009460628,
-0.023799393,
-0.030558905,
-0.005324963,
-0.024430998,
0.02416223,
-0.010824624,
-0.027038045,
-0.01972756,
-0.006658723,
-0.024874464,
-0.03905197,
0.0101594245,
0.007471746,
-0.015091314,
0.014137189,
-0.015669165,
0.0153466435,
-0.0019905618,
0.015991686,
0.026621455,
-0.015749795,
0.023449995,
-0.0106297685,
0.016367963,
0.00693421,
-0.037170593,
-0.007982405,
0.043298498,
-0.0013085634,
-0.023019966,
0.015104753,
0.0036317254,
0.016569538,
-0.016690483,
0.008997004,
-0.011019481,
0.008177262,
0.020681685,
-0.02715899,
-0.003527578,
0.011657805,
0.0014202701,
-0.012417074,
0.0038299419,
0.000768928,
0.02006352,
0.000008398995,
-0.0075994106,
-0.024269735,
0.00911123,
-0.017752117,
0.005855779,
0.029134434,
0.0015529742,
0.0061648623,
0.042465318,
-0.014647847,
-0.01587074,
0.004532098,
-0.013586215,
-0.026083918,
0.028623775,
0.0064403494,
-0.014110312,
0.007989124,
-0.012181902,
-0.018370282,
-0.008405714,
-0.0075523765,
-0.008466187,
-0.029779477,
0.016529223,
-0.0018108233,
-0.010811186,
0.009131388,
-0.013418235,
-0.017066758,
-0.011724997,
0.0071559437,
-0.012625369,
-0.038568184,
-0.004663122,
-0.0061211875,
-0.006927491,
0.00012472508,
-0.015386959,
0.017926816,
-0.025653891,
0.012396917,
0.19652304,
-0.010038479,
-0.0071089095,
0.011509983,
-0.013115871,
0.0020342367,
0.008519941,
-0.014620971,
0.003567893,
0.009883937,
0.0127463145,
0.008284769,
-0.0016907178,
-0.002848939,
-0.004522019,
-0.0028187027,
-0.035316095,
-0.016596414,
-0.015386959,
-0.0022122953,
0.01990226,
-0.010690241,
0.024713203,
-0.011221058,
0.014338764,
-0.015494466,
-0.0029883625,
-0.020695124,
0.022509307,
-0.0053148842,
-0.036391165,
0.00995113,
-0.011274811,
-0.0060640746,
0.0046362453,
0.017362403,
-0.011093393,
-0.011012763,
-0.0051166676,
-0.013814667,
-0.000040892606,
0.0016923975,
0.016811429,
-0.018101513,
-0.0018377001,
0.016247015,
-0.0067158365,
-0.027548704,
0.005741553,
0.0026507229,
-0.063429214,
0.012705999,
0.011496545,
0.033327214,
-0.007955528,
-0.003151303,
0.0075926916,
0.0037257941,
0.0011145467,
0.023087157,
-0.02381283,
-0.0058960947,
-0.01972756,
0.013263693,
-0.021837387,
0.016596414,
-0.01177875,
0.008459467,
0.023261856,
-0.03375724,
-0.0007647285,
0.0004947008,
-0.01445971,
-0.0010145986,
-0.0045522554,
-0.000886094,
0.025936097,
-0.000093753784,
0.01588418,
0.041497756,
0.01873312,
0.0024592257,
-0.024054723,
-0.00021921378,
0.013149466,
-0.02406816,
0.01687862,
0.023114035,
0.011059796,
-0.008755112,
0.017523663,
-0.013283851,
-0.0010733915,
-0.013666845,
0.01814183,
0.0030622736,
0.011476387,
-0.009373278,
0.01705332,
-0.008318365,
-0.0486201,
0.07192227,
0.0008953329,
-0.000035197038,
-0.0060775126,
-0.013519023,
-0.007989124,
-0.015816988,
0.009386717,
-0.02022478,
0.01963349,
-0.024619134,
0.0044649057,
0.0018343405,
0.0030605937,
0.012571616,
0.009480786,
-0.014768793,
0.045448642,
-0.016757675,
0.0041894186,
-0.024928218,
-0.0004396874,
0.017765554,
-0.009816745,
0.00009706089,
-0.012820226,
-0.0055063814,
-0.0024390682,
-0.021850826,
0.000376065,
0.008325084,
-0.012773192,
0.021299852,
0.0035578143,
-0.015104753,
0.025586698,
-0.018235898,
0.0008936531,
0.014526902,
-0.03101581,
-0.00960845,
-0.0059128925,
0.006534418,
-0.00041910986,
-0.016784552,
0.002968205,
0.019754436,
-0.00593305,
-0.03687495,
0.021031084,
-0.009978007,
-0.013424953,
-0.014970369,
0.015171945,
-0.03760062,
-0.010959009,
-0.03201025,
0.00802272,
0.023100596,
-0.026137672,
-0.0032285738,
0.015077876,
-0.0012774871,
0.0046933587,
0.011509983,
-0.16943125,
0.011933292,
0.00509987,
-0.017456472,
0.012470828,
-0.0010078794,
0.0144059565,
0.0007949649,
-0.0024625855,
-0.0047168755,
0.013680283,
0.004955407,
-0.050689615,
-0.035665493,
-0.009601731,
0.010757433,
-0.017631171,
0.029376326,
0.008533379,
0.011711558,
0.03292406,
-0.027387444,
0.025989851,
-0.0087349545,
0.0061883796,
0.019593176,
-0.0000063451785,
-0.025385123,
-0.0049789245,
-0.008708078,
-0.001679799,
0.012860541,
0.03410664,
-0.0034402283,
0.022939336,
0.006527699,
-0.0076598837,
-0.005644125,
0.0005232574,
0.00393073,
0.00777411,
0.016838305,
0.016730798,
0.000047191854,
-0.011241215,
0.0610103,
0.0016495626,
0.0028103038,
0.026594577,
-0.0077203563,
0.029591339,
0.008452749,
0.028113116,
0.01873312,
0.0019183304,
0.0034335093,
0.011960169,
0.014809108,
-0.009474066,
-0.008412434,
0.0013665165,
-0.029403202,
0.043594144,
-0.018625611,
-0.008566975,
-0.032628417,
-0.0021854185,
0.0042162957,
-0.0120676765,
0.017107073,
-0.004407793,
-0.011093393,
-0.0038500994,
-0.01378779,
0.009406875,
0.016488908,
-0.0026154472,
0.021299852,
-0.013841544,
-0.008009282,
-0.0013883539,
0.008291488,
-0.029322572,
-0.04096022,
0.0065176203,
-0.017967131,
-0.012228937,
0.019405039,
0.00095496577,
0.0053451206,
-0.0024289894,
-0.017899938,
0.0014093514,
-0.013754195,
0.03668681,
0.016448593,
-0.02039948,
-0.005970006,
-0.0224018,
-0.020990768,
0.025264177,
-0.0018612173,
-0.006117828,
0.016744237,
0.027817471,
0.036122397,
0.007989124,
0.011389038,
0.031203946,
-0.015521343,
0.0058221836,
0.014970369,
0.022388361,
0.023517186,
0.010502104,
0.026218303,
-0.001120426,
0.006215256,
-0.015991686,
-0.015897619,
0.08439311,
-0.003544376,
-0.020211343,
-0.0006307645,
-0.0024138712,
-0.020439794,
-0.13019115,
-0.0053451206,
-0.0029161312,
0.02650051,
-0.018598735,
0.022630252,
-0.011274811,
0.0225765,
0.0068233437,
0.042975977,
-0.031042686,
-0.0075120614,
-0.017013004,
0.013102433,
-0.016932374,
-0.009978007,
0.02640644,
-0.02014415,
-0.0089701265,
0.018061198,
-0.0049957223,
0.0074448693,
0.0137138795,
-0.0316071,
0.0057213954,
-0.00785474,
-0.02206584,
0.021407358,
0.010643207,
0.008069755,
-0.0014001125,
-0.010502104,
0.017940253,
0.00060976704,
-0.0127597535,
-0.018571857,
0.009588293,
-0.0466581,
0.042196553,
-0.010219897,
-0.0067998264,
0.0069073336,
0.030155752,
-0.00024441077,
0.019620053,
-0.024874464,
-0.025143232,
-0.002706156,
0.026527386,
-0.0108649405,
-0.0056877993,
-0.010038479,
-0.011012763,
-0.019929135,
0.0044917827,
-0.019001886,
0.0059296903,
0.026876785,
0.0013278811,
-0.0084863445,
-0.015266013,
0.021367043,
-0.0077136373,
0.015091314,
0.049372654,
-0.0074448693,
-0.004804225,
-0.026903661,
0.033569105,
-0.029215064,
0.013760913,
-0.008553537,
-0.02733369,
-0.007048437,
-0.028677529,
-0.008446029,
-0.014473149,
-0.020748878,
0.005899454,
-0.016596414,
-0.001370716,
-0.02273776,
0.007169382,
-0.03152647,
0.026043603,
-0.0039912025,
-0.0037997053,
-0.00994441,
-0.0015680924,
-0.0009457269,
0.019001886,
0.024430998,
-0.0033495193,
-0.017725239,
-0.016233578,
0.006487384,
0.0023853146,
0.0017385919,
0.010764152,
0.03244028,
-0.025842028,
-0.018249337,
-0.059773967,
0.027602458,
0.015481028,
0.009245614,
0.022227101,
-0.002022478,
0.015373521,
-0.008587132,
-0.0066654426,
0.017228018,
-0.010098952,
0.010327404,
0.0115704555,
0.0101325475,
-0.020103835,
0.005382076,
0.031714607,
-0.016435154,
0.01822246,
0.04805569,
-0.0027901463,
-0.024632573,
0.0034771839,
0.013740756,
0.011207619,
-0.0024138712,
0.00079664466,
0.022106156,
-0.010911974,
0.010885098,
0.008412434,
-0.030075122,
0.008533379,
-0.0044313096,
-0.0008684561,
-0.009171703,
-0.019431915,
0.035181712,
0.014647847,
0.02323498,
-0.018397158,
-0.039723888,
0.022106156,
0.0035309375,
-0.016703922,
-0.0054627066,
-0.041013975,
-0.00785474,
0.014002805,
-0.0034570263,
0.015534781,
0.0072432933,
-0.0014849424,
-0.014970369,
0.007895055,
-0.00011769092,
0.004061754,
-0.024538504,
-0.017066758,
-0.032977816,
0.0036182872,
0.029241942,
0.009272491,
0.014916616,
0.017066758,
-0.0021249459,
-0.023181226,
-0.02650051,
0.010623049,
-0.03184899,
-0.0039844834,
0.03184899,
0.022374922,
0.021514867,
0.004112148,
0.004498502,
-0.019861944,
0.0002164841,
0.009050757,
0.017913377,
0.011140428,
0.008204139,
-0.021084838,
0.009138106,
0.017805869,
-0.020735439,
0.005398874,
0.026204865,
0.0035578143,
-0.008808866,
-0.0027212745,
0.028596899,
-0.0017705081,
-0.010723837,
0.017658047,
0.014903177,
-0.019593176,
-0.0062286947,
0.012470828,
0.019028764,
0.004854619,
0.0021215861,
-0.015534781,
-0.003954247,
-0.0049856436,
-0.0013547579,
-0.029268818,
-0.03786939,
-0.030558905,
-0.013270413,
0.01245067,
-0.007129067,
0.019109394,
-0.005298086,
-0.004290207,
0.012383479,
0.021393921,
0.0038668974,
0.00025238981,
0.02900005,
-0.001144783,
0.006484024,
-0.008997004,
0.015601973,
0.012672404,
0.016784552,
0.024121914,
-0.022764636,
0.014069997,
-0.0032117758,
0.029322572,
-0.016367963,
-0.051227152,
-0.03109644,
0.00079664466,
-0.0069140526,
-0.0020157588,
0.02324842,
-0.020291973,
0.09675642,
0.0129949255,
-0.0018964931,
-0.0026473633,
-0.0051166676,
0.02398753,
0.022697445,
0.016932374,
-0.02382627,
-0.030988932,
0.0022929257,
0.0025213782,
0.020506987,
-0.034294777,
-0.03961638,
0.04104085,
-0.004649684,
0.0067494325,
-0.0051502637,
0.0051536234,
0.00952782,
-0.019673806,
0.0066251275,
0.011926573,
-0.009984725,
0.004364118,
0.024256298,
0.014567217,
-0.0023769157,
-0.033461597,
0.0071559437,
-0.0081907,
-0.0208967,
-0.015333205,
0.013828105,
-0.01587074,
-0.024041284,
-0.01830309,
0.027185867,
0.0024894623,
-0.009756273,
0.009420313,
0.006245493,
-0.018961571,
0.0072836084,
0.0003710256,
0.0034536668,
-0.004606009,
-0.032735925
] |
Methylation of histones has been regarded as a stable modification defining the epigenetic program of the cell, which regulates chromatin structure and transcription. However, the recent discovery of histone demethylases has challenged the stable nature of histone methylation. Here we demonstrate that the JARID1 proteins RBP2, PLU1, and SMCX are histone demethylases specific for di- and trimethylated histone 3 lysine 4 (H3K4). Consistent with a role for the JARID1 Drosophila homolog Lid in regulating expression of homeotic genes | [
-0.027114458,
0.0011762017,
-0.0021298565,
-0.03494811,
-0.029593796,
0.02587479,
-0.009495336,
0.009996478,
-0.0034849201,
-0.0011696077,
-0.002939268,
0.0033299616,
0.000033201737,
-0.0032409427,
-0.026415497,
0.009290922,
0.015258477,
-0.012732982,
0.0015957439,
0.018885167,
-0.031677496,
0.010095388,
0.0033860104,
-0.0033101796,
-0.010253644,
0.027773857,
0.020625979,
-0.037005432,
0.005473006,
0.002663969,
0.013675921,
0.0033019371,
0.005364205,
0.0039926567,
-0.016181635,
0.0034420593,
-0.007470983,
-0.020652356,
0.008928253,
-0.0061851563,
0.008473269,
0.016775094,
0.007444607,
-0.0111702075,
-0.013662733,
-0.007457795,
0.021496385,
-0.007807276,
-0.007794088,
0.0029508073,
0.017223485,
0.024213105,
-0.015799183,
-0.0020705108,
-0.006620359,
-0.013623169,
0.02956742,
0.021483198,
0.00039131168,
-0.008506238,
-0.003468435,
-0.013926492,
-0.028090369,
0.0140451845,
0.0037948373,
0.018449964,
0.010695441,
-0.008005096,
0.01620801,
0.0048861415,
0.025650594,
0.0041871793,
0.0017045446,
-0.015838748,
0.023487767,
-0.031598367,
-0.010352554,
-0.004658649,
0.012258215,
0.0041410215,
0.028644262,
-0.009396426,
-0.010200892,
0.0027183695,
0.010576749,
-0.0047674496,
0.010814132,
0.004826796,
0.025307707,
0.00086875726,
0.024344986,
0.03993316,
0.04130471,
0.009363456,
-0.024358174,
0.022142595,
0.014546326,
0.021562325,
0.019478627,
-0.0076028625,
-0.010543779,
0.009020569,
-0.015152973,
-0.004731183,
-0.03378757,
0.0038640741,
0.0051301187,
-0.015680492,
0.016484957,
0.008981005,
-0.013609981,
0.012587913,
0.014717771,
-0.04900648,
0.037058186,
-0.017539995,
0.005126822,
0.0055092727,
0.00017061931,
-0.0008539208,
0.008018283,
0.055864226,
0.027984865,
-0.028828895,
0.02756285,
0.0057928143,
-0.020929303,
-0.0076885843,
0.0064456183,
-0.0065610134,
0.030015811,
0.010069013,
-0.013636357,
-0.011493312,
-0.018067515,
0.011486718,
0.0053609083,
-0.012073583,
-0.01776419,
-0.039247386,
0.0028321159,
0.02405485,
-0.021232625,
-0.0076160505,
0.01666959,
0.00010323705,
-0.007029186,
0.010022854,
-0.0060137124,
0.011288899,
0.00067093776,
-0.00585216,
0.008908471,
-0.0032343487,
0.0038146193,
0.021245813,
0.024160353,
0.012976958,
-0.012508786,
0.012027425,
0.0011588925,
-0.007325915,
0.021562325,
-0.00037235397,
0.016709153,
0.029145405,
-0.0037190064,
-0.01157244,
-0.024081226,
-0.015363981,
-0.008235885,
-0.0012512082,
-0.04396868,
0.0034321682,
-0.019465439,
0.02405485,
0.001965007,
0.014823274,
-0.0431774,
-0.0139396805,
-0.0039135288,
0.021034807,
0.026178112,
0.019847888,
-0.008928253,
-0.008407328,
-0.00007850961,
-0.015166162,
0.009818441,
-0.025057135,
0.018146642,
0.018924732,
-0.010669065,
-0.015667304,
-0.62964624,
-0.03481623,
0.01491559,
-0.01322753,
0.0011555955,
0.035317373,
0.022854745,
0.0016287138,
0.005077367,
0.013596794,
0.006247799,
0.016155258,
0.025426399,
-0.036240533,
-0.027721105,
-0.034789857,
-0.013517666,
-0.028486008,
0.027457345,
-0.013794613,
-0.040170547,
0.0060631675,
-0.01258132,
-0.005825784,
-0.0018281818,
-0.003109063,
0.023566896,
-0.00105751,
-0.0069698403,
0.02036222,
-0.018384025,
0.01718392,
-0.009976696,
0.0037618673,
0.044047806,
0.0070225922,
0.0013501181,
0.029250909,
0.01316159,
0.016801469,
0.008216103,
-0.01647177,
0.020533664,
0.018515905,
0.0013039601,
0.012785734,
-0.0049026264,
0.038798995,
0.015205725,
-0.011097673,
-0.0126604475,
0.0054268483,
-0.022538234,
-0.010141546,
0.0240021,
0.035950396,
0.019465439,
-0.010458057,
0.015851935,
0.01549586,
-0.0029771833,
0.027140835,
-0.014480387,
0.0081106,
-0.0056741224,
0.00998329,
-0.012113147,
0.021179873,
0.006798397,
-0.008855719,
-0.012462628,
0.012673636,
0.014744146,
-0.0033728224,
-0.0005192762,
0.025531903,
0.013247312,
0.011242741,
-0.015706867,
0.01089326,
0.010293208,
-0.011552659,
-0.026257241,
-0.015060658,
0.04299277,
0.003916826,
0.0034552473,
0.031097224,
-0.0154826725,
0.001000637,
0.013807801,
0.0020490803,
0.009350268,
-0.008143569,
-0.035185494,
0.007108314,
-0.010003072,
-0.010827321,
0.0023062455,
-0.011064704,
-0.013431944,
0.003916826,
0.008216103,
0.0104646515,
-0.0021249112,
-0.00034556593,
-0.0339722,
-0.0026013264,
0.030701585,
0.005202653,
0.014506763,
0.0052619986,
-0.013675921,
-0.009897568,
-0.02872339,
-0.021311752,
0.022234911,
0.005192762,
-0.0154826725,
-0.04267626,
0.0073456974,
-0.00333161,
0.006785209,
-0.0048597655,
0.009165636,
0.023421828,
0.007866622,
-0.0002540744,
-0.0041146455,
-0.013900116,
0.016643213,
0.0061851563,
0.03521187,
-0.034077704,
0.025597842,
0.0039267167,
0.012192274,
-0.012746169,
0.036741674,
-0.019557754,
0.0008168297,
-0.0030843357,
0.0035805327,
-0.009112884,
-0.013220936,
-0.027061706,
-0.014585891,
-0.0016740474,
0.021812895,
0.0139396805,
0.0017952119,
0.01776419,
-0.011658162,
0.01913574,
-0.0039926567,
0.0029986138,
-0.0353965,
-0.0058060023,
-0.015100221,
-0.013794613,
-0.0039399047,
0.022762429,
-0.010088794,
-0.020269904,
0.0016550898,
-0.03916826,
0.015944252,
-0.010998764,
-0.019491814,
-0.02023034,
0.008308419,
0.011038328,
-0.03130823,
-0.0132341245,
-0.018502716,
0.0290399,
-0.015983814,
-0.00023532278,
-0.014744146,
-0.008380952,
-0.014876026,
0.008565584,
-0.021971151,
-0.012436252,
0.043546665,
0.013900116,
0.0158915,
0.01426938,
0.021034807,
0.024925256,
-0.0012454386,
0.027457345,
0.008684276,
0.00016021318,
0.014216628,
-0.042940017,
0.03613503,
0.011071297,
-0.00960084,
0.028380504,
0.015614552,
-0.007965531,
0.0005089731,
-0.038535237,
0.00018741336,
-0.01699929,
-0.004256416,
-0.00706875,
-0.009673373,
0.005057585,
-0.001000637,
-0.004305871,
-0.016946537,
-0.007312727,
-0.007431419,
0.0078270575,
-0.017289424,
0.007108314,
-0.02412079,
0.005773032,
0.017711438,
0.018080702,
0.029541044,
-0.005482897,
-0.0023721855,
-0.023263572,
0.005921397,
0.016854221,
-0.0021117232,
-0.0075237346,
-0.021667829,
0.014480387,
-0.014229815,
0.009112884,
0.010174516,
0.021113934,
0.023593271,
-0.021232625,
0.034209583,
-0.0051597916,
-0.010589937,
0.004543254,
0.0026244053,
-0.017091604,
0.008394141,
0.0029738864,
0.03716369,
0.0027018846,
-0.0155090485,
0.0169861,
-0.0029639953,
0.0019913828,
-0.01157244,
0.00042902102,
0.016498147,
-0.0126340715,
0.0064983703,
0.021259002,
0.03428871,
0.010899854,
-0.0068577426,
-0.0041014575,
-0.0015149676,
-0.024410926,
0.022749241,
0.0033794164,
0.0014292458,
-0.00018081938,
-0.01971601,
-0.016484957,
-0.018687349,
0.020480912,
0.0076358323,
-0.028169496,
0.022327228,
0.0015767862,
-0.011994455,
0.008077629,
0.006584092,
0.017632311,
0.008084224,
-0.037902214,
0.03716369,
0.010629501,
-0.018120266,
-0.01387374,
-0.0311236,
-0.016841033,
0.0044773147,
0.028433256,
-0.0019501705,
0.0013740213,
-0.009290922,
0.028222248,
-0.005489491,
-0.0070753437,
0.013820989,
-0.024041662,
0.019610506,
-0.0028007943,
0.00057244016,
0.0013286876,
0.0030744446,
-0.008796373,
0.02801124,
-0.00023491065,
0.0019204976,
-0.009429396,
-0.016062943,
-0.010754786,
-0.004365217,
-0.0041179424,
-0.00022048631,
-0.007833652,
-0.007378667,
-0.0017408115,
-0.0064654006,
0.007906185,
0.009574464,
0.020599604,
-0.041383836,
-0.008598554,
-0.008064441,
0.017104791,
0.024635121,
0.047212917,
-0.0155618,
0.026573751,
0.00075872015,
0.007952344,
-0.008605148,
-0.018726911,
0.02451643,
-0.010003072,
-0.013860553,
0.016155258,
0.0040948633,
0.0036233938,
0.00436192,
0.009257953,
0.0019567644,
-0.025043948,
-0.009534899,
0.010134952,
0.0010830617,
-0.005891724,
0.00006068525,
0.017487243,
0.019729197,
0.0031865423,
0.008466674,
0.01860822,
0.0028502492,
-0.016577274,
0.009910757,
-0.0106492825,
-0.007411637,
0.02133813,
0.0022963546,
-0.031018097,
0.017487243,
0.013702297,
0.010880073,
0.001379791,
0.0009816792,
0.011077892,
0.0008122963,
0.015179349,
-0.005947773,
0.010550373,
-0.00930411,
0.015469484,
-0.013847364,
-0.009759095,
0.018647784,
-0.025927542,
0.009515118,
-0.004012439,
0.016854221,
-0.0015347495,
0.01581237,
-0.016722342,
-0.019439062,
-0.012258215,
0.0029161891,
-0.0033151251,
0.009284329,
-0.0008349631,
-0.004312465,
-0.001466337,
-0.0068643363,
-0.014796898,
-0.027272714,
-0.004203664,
0.007886404,
-0.017487243,
-0.030965345,
0.011625192,
0.013820989,
0.016775094,
0.014730958,
-0.031070849,
0.013009929,
0.028037617,
-0.024621934,
-0.0072797574,
0.022076655,
-0.025083512,
-0.009145855,
0.0026755086,
-0.0052718893,
-0.014427635,
-0.04908561,
0.020480912,
0.01990064,
-0.004826796,
0.03502724,
-0.02496482,
-0.031545617,
0.017882882,
0.02289431,
0.044522572,
0.005001536,
0.0024859316,
-0.0077413362,
-0.013807801,
-0.029224534,
-0.037928592,
0.008981005,
-0.028433256,
0.0072929454,
0.012310967,
-0.026771571,
0.003959687,
-0.0061422954,
-0.009554681,
-0.00473448,
0.014374883,
0.042280618,
0.02354052,
-0.02956742,
0.024595557,
-0.0015776105,
-0.0028073883,
-0.01167135,
-0.02938279,
0.012066989,
0.008638117,
-0.025597842,
0.007015998,
-0.004355326,
-0.029488292,
-0.010833914,
-0.0061324043,
-0.0036003147,
0.0452611,
-0.011282305,
-0.022261286,
-0.009449177,
-0.0068445546,
-0.005126822,
0.00043891201,
-0.0028486007,
-0.013300064,
-0.009877787,
-0.0037321944,
-0.0008197145,
-0.012409876,
-0.0060301977,
-0.030200442,
-0.008255667,
0.037242815,
-0.017539995,
-0.00326567,
-0.002363943,
-0.003305234,
-0.00292608,
-0.0084271105,
-0.0065379343,
-0.03054333,
0.02729909,
-0.0015091979,
0.037559327,
0.02983118,
0.03183575,
-0.010919636,
0.006162077,
0.0053839874,
0.03175662,
-0.019689634,
-0.00097178825,
0.013168184,
-0.027008954,
0.01322753,
0.0067357537,
-0.007444607,
0.016959725,
-0.0083743585,
0.025558278,
0.032020383,
-0.017896071,
-0.02930366,
0.026217677,
-0.03930014,
-0.03267978,
0.01607613,
-0.013781425,
-0.01451995,
-0.04850534,
-0.0048465775,
0.0027134242,
-0.0064225397,
0.016801469,
-0.031545617,
0.035317373,
-0.0112757115,
0.040091418,
0.003135439,
0.000019408462,
-0.005064179,
-0.016234387,
-0.011921922,
0.016709153,
0.025123077,
-0.0018281818,
0.01971601,
0.0027398,
-0.025228579,
0.0066698138,
0.019570941,
-0.01177026,
-0.0071412837,
-0.014638643,
-0.010669065,
-0.01322753,
-0.026692444,
-0.00960084,
-0.049797762,
0.009053539,
0.008565584,
-0.00585216,
0.00086546026,
-0.00006238526,
-0.0071017197,
0.03573939,
-0.007899592,
0.022920685,
-0.008888689,
0.009501929,
0.017289424,
0.0024595556,
-0.0032557792,
-0.013781425,
-0.012957177,
0.0068379603,
0.043863177,
0.02431861,
-0.006518152,
-0.012732982,
0.009811847,
-0.0013492937,
-0.01349129,
-0.02211622,
-0.012943989,
-0.023962535,
-0.006620359,
0.0118362,
0.012370313,
-0.024740625,
-0.0067918026,
-0.0003115657,
0.024173543,
-0.016761905,
0.0017985089,
-0.017302612,
0.009574464,
0.006689596,
0.005018021,
0.022973437,
-0.010695441,
0.0045267693,
-0.02133813,
-0.0187401,
0.016379453,
-0.01177026,
0.025769286,
-0.002337567,
0.0048729535,
-0.0109592,
0.016577274,
0.002899704,
-0.018318085,
-0.016379453,
0.036609795,
-0.015126597,
-0.000987449,
0.0033233676,
0.0033678769,
0.0009165637,
-0.007352291,
0.0059906337,
-0.0052652955,
-0.033761192,
-0.00551257,
0.023263572,
0.0038376981,
-0.019399498,
-0.016155258,
-0.025848413,
0.0045036906,
-0.033233676,
-0.015284853,
0.014638643,
-0.0389045,
-0.006732457,
0.015007906,
0.009396426,
0.021971151,
0.021245813,
0.013675921,
-0.0035805327,
0.024687873,
-0.021681016,
0.017539995,
0.010669065,
-0.0032739127,
-0.028486008,
0.0010253644,
-0.013135214,
-0.053042002,
0.0019600615,
-0.017751003,
-0.03041145,
-0.00913926,
0.0029920198,
0.0086579,
0.014216628,
-0.010227268,
0.009013975,
-0.0052389195,
0.022314038,
-0.008519426,
-0.008308419,
0.00943599,
-0.042834513,
-0.0075501106,
0.019808326,
-0.002161178,
-0.019082988,
0.000980855,
-0.030358698,
0.007708366,
-0.012357124,
0.00009417032,
-0.011730696,
0.0075501106,
-0.00930411,
0.009554681,
0.007840246,
-0.008077629,
-0.018054325,
-0.017526807,
-0.0021051292,
0.004216852,
-0.018792853,
0.0032805067,
-0.005769735,
-0.020006144,
-0.016590461,
-0.009145855,
0.0083282,
-0.043019146,
-0.039643027,
-0.006656626,
-0.023936158,
0.032178637,
0.0026507813,
-0.008064441,
-0.015047469,
-0.0014069912,
-0.03566026,
-0.012614289,
0.0027134242,
-0.010200892,
0.003916826,
0.011460342,
0.013544042,
-0.019505002,
-0.00794575,
0.026956202,
0.021113934,
-0.023804279,
0.006501667,
-0.018924732,
0.02956742,
0.003959687,
-0.022986624,
-0.0064686975,
0.017816942,
-0.0021941478,
0.016300326,
0.021826085,
-0.0070621558,
0.009844817,
-0.0036497696,
0.024872504,
0.013089056,
0.018120266,
0.028934399,
-0.022722866,
-0.0049718632,
0.016300326,
0.0026936422,
-0.03729557,
-0.0061324043,
-0.0040487056,
0.012574726,
0.014361695,
-0.008697464,
-0.015258477,
-0.002919486,
-0.045313854,
0.02425267,
-0.0069962163,
0.01549586,
0.0126340715,
0.0010237158,
0.00032969916,
-0.016036566,
-0.0015875014,
-0.025993481,
-0.026217677,
0.004665243,
-0.009574464,
-0.0025320896,
0.0037552733,
-0.00011467349,
-0.024384549,
0.009218388,
-0.0048333895,
-0.014440823,
-0.0039399047,
0.003930014,
-0.03534375,
-0.0032162152,
-0.016775094,
-0.01692016,
-0.017777378,
0.005001536,
0.0042267432,
-0.01170432,
-0.009323892,
0.013438538,
-0.007708366,
-0.010840508,
-0.0023144882,
0.0056114797,
-0.0158915,
-0.0032541307,
0.022775618,
0.19992957,
-0.0036332847,
-0.003873965,
0.0027150726,
0.00018143757,
-0.014308943,
0.02307894,
-0.005581807,
0.00096437003,
-0.007372073,
0.025861602,
-0.001266869,
-0.021364504,
0.0016600352,
0.021377694,
-0.0133923795,
-0.025307707,
-0.009521712,
-0.040170547,
-0.006234611,
0.013847364,
-0.013497883,
-0.01996658,
-0.004276198,
0.03442059,
-0.0048366864,
-0.03592402,
0.00026581995,
-0.0127395755,
-0.00028745644,
-0.044970963,
0.0043981867,
0.0071280957,
-0.009172231,
0.017777378,
-0.001965007,
-0.02450324,
0.010088794,
0.0037552733,
-0.0020787532,
0.00289311,
0.0106492825,
-0.009277734,
-0.02698258,
0.0011333409,
-0.006610468,
-0.003125548,
0.0041410215,
0.0022897606,
-0.0043454347,
-0.031730246,
0.027114458,
0.01173729,
0.03618778,
0.009060133,
-0.018581845,
0.00013960699,
0.009785471,
-0.0072072237,
0.02296025,
-0.031862125,
-0.0052554044,
-0.022907497,
0.0040750816,
-0.011493312,
0.017566372,
-0.020995243,
0.0039827656,
0.030701585,
-0.038034096,
0.0067522386,
-0.005466412,
-0.025083512,
-0.0069962163,
0.0012421416,
-0.03502724,
0.045894124,
0.028617887,
0.03302267,
0.04170035,
0.0091326665,
-0.011987861,
-0.034156833,
0.016392643,
0.01011517,
-0.04148934,
0.02483294,
-0.0049817543,
-0.046026003,
-0.02354052,
0.008981005,
-0.016564086,
-0.008097411,
0.0040190327,
0.026771571,
0.0040948633,
0.012284591,
0.020085273,
-0.017091604,
0.00544663,
-0.03289079,
0.07685947,
-0.0020391892,
0.022129407,
-0.01912255,
0.019874265,
0.0008361995,
0.01186917,
0.008486456,
-0.007108314,
0.03286441,
-0.024674686,
0.020784235,
-0.0055092727,
0.001443258,
0.008163351,
-0.003115657,
-0.028670639,
0.031888504,
0.005848863,
-0.008928253,
0.015944252,
0.0065643103,
0.024753813,
-0.0155618,
-0.012601102,
-0.017012477,
0.00085639354,
-0.0112757115,
-0.035290997,
-0.011064704,
0.012489004,
0.011110862,
0.009752501,
-0.015218913,
-0.028802518,
0.009126073,
0.009449177,
-0.012034019,
0.016287139,
-0.012238433,
0.00389045,
0.013280282,
0.011414185,
-0.01958413,
-0.001439961,
0.0060038217,
0.011480125,
-0.0036893336,
-0.00008850362,
-0.019834701,
-0.014440823,
0.0020095163,
0.0016946536,
0.005960961,
-0.02314488,
-0.0010055824,
-0.033761192,
-0.023711963,
-0.0040882695,
-0.0339722,
0.016445395,
0.007431419,
-0.008644712,
-0.014638643,
-0.0024694467,
-0.16542985,
0.0012676932,
0.017157543,
-0.029804803,
0.011394403,
0.030622458,
0.019465439,
-0.011064704,
-0.025571467,
0.0033991984,
0.013240718,
0.0010814132,
-0.038798995,
-0.043546665,
-0.0022699786,
0.027510097,
0.0056609344,
0.04597325,
0.0062247203,
-0.011941703,
0.0132341245,
-0.01037893,
0.020586416,
-0.026956202,
-0.0012990147,
0.03220501,
0.026283616,
-0.0059148027,
-0.024358174,
-0.03223139,
-0.008024878,
0.0067522386,
0.01349129,
0.004282792,
0.025479151,
0.007108314,
0.006692893,
0.011842794,
-0.0070094042,
0.02983118,
0.022459107,
0.010458057,
-0.0030678506,
-0.007892998,
0.0020194072,
0.047133792,
-0.002141396,
-0.007807276,
0.030596081,
-0.013517666,
0.0030200442,
0.005931288,
-0.0068709305,
0.013794613,
0.0473448,
0.011888952,
-0.006313739,
0.04475996,
-0.025202204,
-0.016010191,
-0.018515905,
-0.019228054,
0.050246153,
0.013372598,
-0.0016517928,
-0.018990671,
-0.00012106141,
0.030121315,
-0.0290399,
0.0015100221,
0.008367765,
-0.008334795,
0.0010624556,
0.00585216,
0.012442846,
0.00612581,
0.0154035445,
0.0040717847,
-0.015548612,
-0.0011234499,
-0.0028881647,
0.015258477,
-0.016181635,
-0.0296993,
-0.0014391368,
0.009257953,
-0.008334795,
0.008216103,
-0.0008324904,
-0.00020935896,
0.021470008,
-0.024569182,
0.02872339,
0.0007286351,
0.020889739,
0.007378667,
-0.029936682,
-0.024424113,
-0.0036365816,
-0.009073321,
-0.0011729047,
-0.016827844,
-0.009218388,
0.011625192,
0.033813946,
-0.00087782403,
-0.017144356,
0.013900116,
0.056444496,
-0.013649545,
-0.0099173505,
-0.014941966,
0.0072006295,
0.036240533,
0.011368027,
0.028512383,
0.009192012,
-0.011368027,
0.0018380728,
-0.0005023791,
0.067100376,
0.0060170097,
-0.0028255219,
0.014902402,
-0.010174516,
-0.022604175,
-0.12523292,
0.0068709305,
0.0017259751,
-0.0067918026,
-0.00019215279,
0.014941966,
0.014717771,
0.017421303,
-0.009607433,
0.020283092,
-0.02801124,
0.024147166,
0.031783,
-0.022867933,
-0.0071676597,
0.006195047,
0.01587831,
-0.01582556,
-0.011849388,
0.033734817,
0.011295493,
-0.0033134765,
-0.011328463,
-0.021931589,
0.03840336,
0.011803229,
-0.022683302,
0.029620172,
0.014427635,
0.0014704582,
-0.00164932,
-0.023316324,
0.0027876063,
0.011816418,
-0.005904912,
0.0016995992,
0.00059181,
-0.03022682,
0.03249515,
-0.016234387,
-0.0044245627,
0.0065379343,
0.0035805327,
-0.010715223,
0.014480387,
-0.025452774,
-0.0030447717,
0.01711798,
0.005908209,
0.005027912,
-0.044047806,
-0.014401259,
-0.012759358,
-0.028275,
0.015588176,
-0.0134187555,
0.018436776,
0.01815983,
-0.03811322,
-0.03215226,
-0.023698775,
0.0036102058,
-0.011684538,
-0.0064225397,
0.000092985465,
-0.039590273,
-0.0009783822,
-0.024384549,
0.04193773,
-0.021113934,
0.0015026039,
0.021219438,
-0.015614552,
0.00797872,
-0.015311229,
0.024358174,
-0.05718302,
-0.00859196,
0.00078056275,
-0.02845963,
0.0015710165,
-0.014190252,
0.014585891,
-0.015720056,
0.035185494,
0.004368514,
-0.0029046496,
0.0035376719,
0.011203177,
0.0067126746,
-0.0065906863,
0.056497246,
-0.0027150726,
-0.020784235,
-0.021931589,
0.015535424,
-0.018146642,
0.0015281556,
0.011031734,
0.021443633,
-0.0048894384,
-0.01860822,
-0.061508674,
0.005416957,
-0.00044097262,
0.012106553,
0.02042816,
-0.0049718632,
0.007721554,
-0.0068709305,
-0.012765951,
0.02107437,
-0.010425087,
-0.00026046234,
-0.025729721,
-0.016590461,
-0.040302426,
-0.007378667,
0.029277286,
0.009462366,
0.029066278,
0.021733768,
0.005835675,
-0.007081938,
0.0061455923,
0.019030236,
0.0003500993,
-0.003959687,
-0.023250384,
0.005011427,
-0.010121764,
-0.0038212133,
0.0071017197,
-0.037928592,
-0.022010716,
0.0070094042,
-0.015799183,
-0.009640403,
-0.029066278,
0.02594073,
0.00940302,
0.012409876,
-0.011183395,
-0.04291364,
-0.005538946,
0.00066805293,
-0.0031370874,
0.0033431496,
-0.018449964,
-0.008763404,
-0.005532352,
-0.03974853,
0.040434305,
0.0142034395,
-0.0045729275,
-0.024793377,
-0.02605942,
-0.016445395,
-0.025175827,
-0.011414185,
-0.0047938256,
-0.018647784,
-0.004556442,
0.02612536,
0.016564086,
-0.024226295,
-0.005838972,
-0.001044322,
-0.0036167998,
0.0009281031,
-0.006758833,
-0.007569893,
-0.041805852,
-0.0014993069,
0.023105318,
-0.0069104945,
-0.0007933386,
-0.009739313,
-0.010715223,
0.011882357,
-0.039458394,
0.010952606,
0.015205725,
-0.025927542,
-0.007800682,
0.0070094042,
0.02483294,
-0.014229815,
0.003936608,
-0.007985313,
-0.0071149077,
0.03455247,
0.0011242741,
0.019109363,
0.025571467,
0.03378757,
0.0036431756,
0.00043520288,
0.0066994866,
0.0013649545,
0.015139786,
0.037585706,
-0.0111965835,
0.007312727,
0.005136713,
-0.02782661,
-0.0071478775,
0.026797947,
-0.011157019,
-0.027325466,
0.021034807,
0.0012528568,
0.004741074,
0.0119548915,
-0.009310704,
0.005911506,
0.0005056761,
0.0048663598,
-0.007457795,
-0.0106492825,
-0.009422801,
0.038034096,
0.01854228,
0.005838972,
0.018713724,
0.0044937995,
0.017197108,
-0.0010987225,
0.016841033,
-0.0048465775,
0.03022682,
-0.007919374,
0.008084224,
0.004355326,
-0.027378218,
-0.020982055,
-0.012192274,
-0.0014317186,
-0.005410363,
0.038508862,
0.005120228,
0.0863548,
0.014493575,
-0.018449964,
0.004315762,
-0.026309993,
0.038007718,
0.025465963,
0.018779663,
-0.016432205,
-0.006221423,
0.010932824,
-0.040434305,
0.0155618,
-0.025202204,
0.019597318,
0.026639692,
-0.016775094,
0.009066727,
0.010880073,
-0.007965531,
-0.005024615,
-0.012040613,
-0.012976958,
0.0077545242,
-0.030648833,
-0.0040454087,
0.02236679,
-0.02041497,
0.005898318,
-0.0035937207,
0.015680492,
-0.0026689146,
-0.016867409,
-0.0040091416,
0.020639166,
-0.0060236035,
-0.010985576,
-0.014599078,
0.02307894,
-0.006742348,
0.004352029,
-0.021061182,
0.0033629313,
-0.018238958,
0.008361171,
0.010504215,
0.006326927,
-0.016709153,
0.0048729535
] |
Mitochondria are the primary energy-generating system in most eukaryotic cells. Additionally, they participate in intermediary metabolism, calcium signaling, and apoptosis. Given these well-established functions, it might be expected that mitochondrial dysfunction would give rise to a simple and predictable set of defects in all tissues. However, mitochondrial dysfunction has pleiotropic effects in multicellular organisms. Clearly, much about the basic biology of mitochondria remains to be understood. Here we discuss recent work that suggests that the dynamics (fusion and fission) of these organelles is important in development and disease. | [
-0.030973287,
-0.018181656,
-0.0152416425,
-0.024435628,
-0.032778557,
0.019496923,
-0.025364054,
0.018310603,
-0.0073564784,
-0.0042165965,
0.008807142,
0.017975338,
0.016776122,
0.006963187,
-0.020709034,
0.0003201535,
0.03760121,
-0.01005149,
-0.014983747,
0.010773598,
-0.017291915,
0.014145586,
0.0035106067,
-0.025750898,
0.032443292,
0.034248564,
-0.003891003,
-0.034042247,
-0.019625872,
-0.023790888,
0.0024983657,
-0.0024580695,
-0.010509254,
-0.018645868,
0.015112695,
0.0035073832,
0.006602133,
-0.0024177732,
-0.0010323892,
0.0070212134,
-0.004519624,
0.011624654,
-0.004223044,
-0.004351992,
0.0007208994,
0.013900585,
0.0016585925,
0.0033881064,
0.0067439754,
0.0109154405,
0.018349288,
0.022282198,
-0.006218513,
-0.0069373976,
-0.0140037425,
-0.01700823,
-0.036234364,
0.0058413404,
0.008742669,
-0.005886472,
-0.0128238695,
-0.02215325,
-0.022939833,
0.0035492913,
-0.0022807661,
0.016647175,
0.01794955,
0.019664556,
0.00925846,
0.0136684785,
0.033062246,
0.0018326722,
0.0060057486,
0.025802476,
0.025725108,
-0.017640075,
-0.03757542,
-0.0133332135,
-0.01727902,
0.018581394,
0.011624654,
-0.010225569,
0.0056833792,
0.041366488,
-0.00999991,
-0.015177169,
0.00087926356,
0.004477716,
0.014442165,
0.0075370055,
-0.003733042,
0.0041682413,
0.033810142,
0.02371352,
-0.035383306,
0.0039103455,
0.0056543658,
0.029735388,
-0.019716136,
-0.026150636,
0.010722019,
0.012404789,
-0.029193807,
-0.015460854,
-0.036131203,
0.024113258,
0.0024822473,
0.0045389663,
0.014919273,
-0.0087168785,
-0.015821908,
0.03017381,
-0.018632973,
-0.032288555,
0.016195858,
0.0010291655,
0.033526458,
0.0044873874,
-0.0007910148,
-0.012662685,
0.019316398,
-0.010902545,
0.036053836,
-0.027465904,
0.016892176,
-0.007807796,
0.0073435833,
0.0011903504,
-0.0070018712,
-0.007943192,
0.00639904,
-0.0037459368,
0.0036911338,
-0.00092278345,
-0.029142227,
-0.015280327,
-0.018336393,
-0.01326874,
-0.0043068603,
-0.0289617,
0.017936654,
0.028420119,
-0.032778557,
-0.009264907,
-0.0012951206,
0.037472263,
0.02290115,
0.017885076,
0.010380306,
0.010451228,
0.0071179247,
-0.0069245026,
0.030586444,
-0.0289617,
-0.000048884354,
0.01141189,
-0.011843866,
0.011921234,
-0.013745847,
-0.019741924,
0.009787146,
-0.022810886,
0.0026933996,
0.005151469,
0.016440859,
0.03956122,
0.014132691,
-0.0032172503,
0.026846955,
-0.02554458,
-0.014493745,
0.017536916,
-0.012243604,
0.037214365,
-0.015860593,
0.0039812666,
0.0013450879,
0.015912171,
-0.020231927,
-0.023906942,
0.009142406,
0.005944499,
0.028471699,
-0.0069889766,
-0.017150072,
0.023855364,
0.030509075,
0.006814897,
0.039174374,
-0.013797427,
-0.010257806,
-0.013952164,
-0.0012362881,
-0.0020873442,
-0.6441206,
0.003700805,
-0.0066923965,
-0.009742014,
0.0028384659,
0.016092699,
0.018581394,
-0.0061250255,
-0.0065021985,
-0.0041617937,
-0.030431706,
0.00831714,
-0.007711085,
-0.026692217,
-0.006121802,
-0.022179041,
-0.016002435,
-0.021431142,
0.011818076,
-0.021727722,
-0.003742713,
0.0015070786,
-0.02074772,
-0.0064248294,
-0.020283505,
0.019200344,
0.020696139,
0.0202964,
-0.0014160093,
0.045905456,
-0.012624,
0.007936744,
-0.015190064,
0.0052514034,
0.042320702,
0.0069180555,
-0.015370591,
0.026460111,
-0.0046453485,
0.0178206,
-0.021044299,
0.0140037425,
0.02215325,
0.016544016,
-0.010232016,
0.013184924,
0.020219032,
-0.014945063,
0.010580176,
-0.011328074,
0.0112636,
0.0062765395,
-0.016105594,
0.0034074485,
-0.014068217,
-0.0006939009,
0.022514304,
-0.020038504,
0.0078013483,
0.02290115,
-0.0009679152,
0.01814297,
-0.012810974,
-0.012630448,
-0.016711649,
0.014712957,
-0.019471135,
0.0048065335,
-0.0023500756,
-0.005480286,
0.01156018,
0.0031060327,
-0.017678758,
0.0076724007,
0.011373205,
0.01482901,
0.011792286,
-0.009355171,
-0.01156018,
0.02651169,
0.0033204088,
-0.0004823458,
-0.0074080573,
-0.011811628,
0.0124886045,
0.00571884,
0.0051546926,
0.02309457,
0.012417683,
0.031256974,
0.03329435,
-0.010457675,
0.011734259,
-0.054003384,
-0.008059245,
0.019600082,
-0.017266124,
-0.0007499127,
0.016299015,
-0.018375076,
-0.020283505,
-0.008858722,
-0.0047936384,
0.0032301452,
0.0117600495,
-0.00087039836,
-0.050624948,
0.0013587886,
0.04064438,
-0.015538223,
0.0012193637,
-0.022604568,
-0.0065860143,
0.004039293,
-0.0018149419,
-0.024835367,
0.0097355675,
0.020335086,
0.018310603,
-0.020270612,
-0.0046872566,
-0.008723326,
0.005983183,
-0.029941704,
0.010812283,
0.009432539,
0.024938526,
-0.034429092,
-0.01819455,
0.0020357652,
-0.01695665,
-0.008478325,
0.01019978,
-0.0030850787,
0.022630358,
0.014622693,
0.013771636,
-0.0017859285,
0.016182963,
-0.016595596,
-0.026743796,
-0.030431706,
-0.0068084495,
-0.0021614893,
-0.026305374,
-0.0060960124,
-0.019174553,
-0.007163056,
0.0037169235,
-0.0016086252,
-0.02212746,
0.019625872,
-0.023700627,
0.038091213,
0.024770893,
-0.008272008,
-0.026743796,
-0.013642689,
0.005760748,
-0.0017665863,
0.0011613371,
0.025376948,
-0.017240336,
0.02319773,
-0.017046914,
0.0010831624,
-0.025183527,
-0.020580087,
-0.009535698,
-0.029322755,
-0.015821908,
0.017769022,
-0.007956086,
0.009748462,
-0.0008655628,
0.02042535,
0.0037459368,
-0.01480322,
0.006199171,
-0.008091481,
0.026369847,
-0.023545887,
-0.006995424,
-0.007504768,
0.015680065,
0.013694268,
0.041598596,
-0.0030625127,
-0.00076965784,
0.023159044,
-0.011502153,
0.011785839,
-0.014145586,
0.0056124576,
0.004590546,
-0.024010101,
-0.010844519,
0.0038748847,
-0.00876201,
0.040412273,
0.020489823,
-0.033810142,
0.0020937917,
-0.03700805,
0.021689039,
0.0019358305,
-0.0051740347,
-0.019148765,
0.006505422,
0.012598211,
0.013990848,
0.01784639,
0.011244258,
-0.008562141,
0.010315833,
0.012888343,
0.0012290347,
0.008858722,
-0.018568499,
-0.039251745,
0.020734824,
-0.011966366,
0.019870874,
0.0058381166,
0.015138485,
-0.00018677299,
-0.008458983,
0.013836111,
-0.008942538,
0.013810321,
0.002686952,
0.0027691564,
0.008794247,
0.0006640817,
0.016157173,
-0.003125375,
-0.0008276844,
-0.0023726416,
0.032469083,
0.011340968,
-0.00009706352,
0.028729593,
-0.0057929847,
0.017743232,
0.00061612925,
-0.0043358733,
0.028574856,
0.0038329766,
-0.016737439,
0.003433238,
-0.014248744,
-0.0069438447,
-0.034944884,
-0.016028225,
0.0026950112,
-0.023339571,
0.000101093145,
-0.003978043,
0.03027697,
0.014287428,
0.0078722695,
-0.03087013,
-0.011495706,
-0.011515048,
-0.0070018712,
0.0066923965,
0.039097007,
0.0025402738,
-0.0039200163,
-0.0028320185,
-0.037317526,
0.0017133954,
0.0023952073,
-0.04616335,
0.023429835,
0.020760613,
0.014300323,
0.0111926785,
-0.006357132,
0.012159788,
-0.019883767,
-0.01569296,
0.012636895,
0.018632973,
-0.003039947,
-0.044848084,
-0.038710162,
-0.004148899,
-0.022179041,
0.018684551,
0.008510562,
-0.0097355675,
-0.010767151,
-0.0050386395,
-0.0137845315,
-0.002846525,
0.005493181,
-0.022759305,
0.033810142,
0.0031108684,
0.013655583,
0.005460944,
-0.0024838592,
0.024822472,
0.042165965,
0.035486463,
-0.015409275,
0.006527988,
0.008175298,
-0.02834275,
-0.027285378,
-0.019961135,
0.012385447,
-0.022759305,
-0.0053352197,
0.0019148764,
0.009058591,
0.0020712258,
0.032804348,
0.006121802,
-0.0150998,
-0.025376948,
0.0071050297,
-0.01185676,
0.01571875,
0.03081855,
0.00072130235,
0.007981876,
-0.012656237,
0.0020760614,
0.015280327,
-0.029271176,
0.019806398,
0.0004041711,
0.020064294,
-0.033139613,
0.009387407,
-0.004171465,
0.013010844,
0.017743232,
-0.011940576,
0.0030625127,
-0.010883204,
-0.021018509,
0.016724544,
-0.012114656,
0.028600646,
0.021830881,
0.016105594,
0.017330598,
-0.005973512,
0.022565885,
-0.0051095607,
-0.0007313764,
0.0037233708,
0.015899276,
0.006108907,
0.00863951,
-0.035460673,
-0.0133332135,
-0.0014941839,
0.015950857,
-0.0029287294,
0.014248744,
0.014145586,
0.010896098,
0.010393201,
-0.0033687642,
0.006589238,
-0.0076401634,
-0.007949638,
0.013004397,
0.021302195,
0.0069696344,
0.027465904,
-0.004912915,
-0.0060637756,
-0.038478058,
0.017743232,
-0.014558219,
-0.0028449132,
0.0014788713,
0.0020760614,
0.0016521451,
0.012262946,
0.0007752993,
0.00070760166,
0.001503855,
0.027543273,
0.0073758205,
-0.014055322,
-0.024229312,
-0.038993847,
-0.009393855,
0.003658897,
-0.039071217,
-0.021547196,
0.0026579387,
0.027465904,
0.019935347,
0.006402264,
-0.014932168,
0.014274534,
0.021843776,
-0.0084976675,
-0.005373904,
-0.018800605,
-0.045957036,
-0.01824613,
-0.009870962,
0.009974121,
-0.031695396,
-0.0077239797,
0.0033429745,
-0.015538223,
-0.0035750808,
0.0029786967,
0.0175756,
-0.0144550605,
0.009432539,
0.018542709,
0.023210624,
-0.021856671,
-0.0100708315,
0.004684033,
-0.023146149,
0.008671747,
-0.0418307,
-0.0015594638,
-0.037446473,
-0.009103722,
0.008239771,
0.00058147445,
0.004406795,
0.008871616,
0.0045067295,
0.02780117,
0.018001128,
0.008981222,
0.034686986,
-0.00008819836,
0.027594853,
-0.009767804,
0.015538223,
-0.0071823983,
-0.016350595,
0.03994806,
0.012540184,
-0.011147547,
0.006579567,
-0.012391894,
-0.009013459,
-0.016324805,
0.027208008,
-0.0082204295,
0.039277535,
0.0050612055,
-0.045209136,
-0.021160351,
0.01571875,
-0.008697537,
0.012230709,
0.012830317,
-0.0023516875,
0.009948331,
0.009432539,
-0.016157173,
-0.02279799,
0.017704548,
-0.041727543,
-0.02094114,
-0.0058703534,
0.025970109,
0.0064377245,
-0.018826395,
-0.0050612055,
-0.0356412,
-0.0005746241,
-0.010838072,
-0.029967494,
-0.020837981,
-0.01878771,
0.034970675,
0.03223698,
0.015370591,
0.0033107377,
0.029142227,
0.011353863,
-0.0077046375,
-0.011147547,
-0.0010734913,
0.0017714219,
-0.013436372,
0.019471135,
-0.012340315,
0.0022807661,
0.010193332,
-0.013810321,
-0.010812283,
0.017356388,
-0.023726415,
-0.023984311,
-0.0035235016,
-0.013849005,
-0.012217814,
0.023971416,
-0.03208224,
-0.021095878,
-0.016350595,
0.0015812237,
0.028858542,
0.021676144,
-0.0068277917,
0.0011105639,
0.00035964377,
-0.019703241,
0.010818729,
-0.025389843,
0.0129979495,
-0.016789017,
-0.02903907,
-0.012933475,
-0.012308078,
-0.009980568,
0.0054254835,
0.0069051604,
0.01666007,
-0.006431277,
0.028652225,
-0.008265561,
-0.026795376,
-0.002986756,
-0.0048355465,
-0.010631755,
-0.018426657,
0.0029303413,
-0.00663437,
-0.029838545,
0.013487951,
0.008304246,
-0.011682681,
0.006260421,
-0.011527943,
-0.013359004,
0.032572243,
0.004152123,
0.009039248,
-0.0073951627,
0.025364054,
-0.0002431877,
-0.0016360265,
-0.030431706,
-0.008981222,
-0.0020873442,
-0.006195947,
0.046550196,
0.0035847519,
-0.01096702,
-0.015202958,
0.018117182,
0.0091101695,
-0.0016118488,
-0.0075241104,
0.0012008274,
0.009303591,
-0.00008714058,
-0.01128939,
0.011334521,
0.005944499,
0.010663992,
-0.023584573,
0.0117600495,
-0.018220339,
-0.010999257,
-0.015370591,
0.035486463,
0.0087878,
0.01762718,
-0.013294529,
0.0004001415,
0.013629794,
-0.017240336,
-0.019600082,
0.009819384,
-0.000115952374,
0.018581394,
0.010657544,
-0.009883857,
-0.0058187745,
0.018104287,
0.0016021777,
-0.0202964,
-0.022681937,
0.03760121,
0.005464168,
0.0050741,
0.022643253,
0.0071823983,
0.0031479408,
-0.0140037425,
0.0040779775,
-0.0026692217,
-0.027208008,
-0.013681374,
0.03455804,
0.022462726,
0.014635588,
-0.017536916,
-0.012817422,
0.003668568,
-0.026898533,
-0.03084434,
-0.0027143534,
-0.02505458,
-0.014957958,
0.013320319,
0.008078586,
0.013023739,
-0.01760139,
-0.015447959,
-0.024151944,
0.031669606,
0.013629794,
0.032804348,
0.0038458714,
-0.0052030482,
-0.008207534,
0.00015856563,
-0.013552425,
-0.010206227,
-0.0051450217,
-0.02403589,
-0.041366488,
0.0047871913,
-0.003787845,
0.030741181,
-0.0012943146,
-0.010844519,
0.019922452,
-0.00084944436,
0.015499539,
-0.0033881064,
-0.022295093,
0.020489823,
-0.013836111,
0.007124372,
0.007440294,
-0.0074725314,
-0.020489823,
0.013771636,
-0.04082491,
-0.0068922658,
0.0053706802,
-0.013758742,
-0.030457497,
0.011895444,
-0.01663428,
0.0064473953,
-0.0004839576,
-0.017665863,
-0.024861157,
0.0048387703,
0.021663249,
0.0036846865,
-0.031824343,
-0.01542217,
0.028162224,
0.023326676,
-0.01685349,
-0.005151469,
-0.016273227,
-0.014339007,
-0.010064384,
-0.012617553,
-0.010244912,
0.024190627,
0.0027820512,
0.00048073393,
0.0030238284,
-0.0070341085,
-0.052636538,
-0.034429092,
0.011128205,
0.029090649,
0.014274534,
0.028652225,
0.0024854708,
-0.0034493566,
0.011598865,
0.018001128,
-0.025015894,
-0.02225641,
0.023571678,
0.0006511869,
0.0072855568,
-0.015963752,
-0.026743796,
-0.0032220858,
0.032520663,
-0.021005614,
-0.0163377,
-0.0026821166,
-0.002719189,
0.014145586,
-0.0038329766,
0.011798734,
0.0023935956,
0.027620642,
0.033474877,
-0.018130075,
-0.015383486,
0.009142406,
-0.023636151,
-0.014222954,
-0.005254627,
-0.0014659766,
0.016105594,
0.012869001,
-0.0069051604,
-0.031024868,
0.0058639063,
-0.012624,
0.00424561,
0.026099056,
0.0026805047,
0.004413242,
0.020257717,
-0.018026918,
-0.023455625,
-0.01019978,
-0.009484119,
0.003176954,
0.018413762,
0.006560225,
-0.032108027,
0.0059251566,
-0.00896188,
-0.036595415,
-0.03146329,
-0.014751641,
-0.002113134,
-0.04324913,
0.0060186437,
0.0053803516,
-0.0023275097,
-0.012985054,
0.010773598,
0.0006922891,
-0.0065956856,
-0.0073435833,
0.004429361,
0.006128249,
0.0065731197,
0.012114656,
-0.020064294,
-0.02284957,
0.00501285,
-0.017485337,
-0.037781738,
0.015499539,
0.18228076,
-0.032933295,
0.006566672,
0.029193807,
0.0012532125,
-0.0074596363,
0.0051127844,
-0.021469828,
0.0023903719,
0.010064384,
0.025621949,
0.014532429,
-0.009883857,
0.006247526,
0.035434887,
-0.0077691115,
-0.021766407,
0.006079894,
-0.026060373,
-0.0035138305,
-0.013384793,
-0.024010101,
0.010096622,
-0.0024500103,
0.029786967,
-0.0007708667,
-0.03386172,
0.0057123923,
0.0128238695,
0.0025241554,
-0.004364887,
-0.007143714,
0.002121193,
0.0094583295,
0.014429271,
-0.009613067,
-0.0035750808,
-0.009658199,
0.016827703,
-0.020476928,
-0.00003331994,
0.0080463495,
0.0012346762,
0.0016908294,
0.0227722,
0.041572805,
-0.010045042,
-0.014712957,
-0.010979914,
-0.0012556303,
-0.050392844,
-0.0033139612,
0.00569305,
0.021134563,
0.0015433453,
-0.0046937037,
0.0023726416,
0.010612413,
0.0075241104,
0.027878538,
-0.016827703,
-0.0051063374,
-0.002132476,
0.032443292,
-0.020696139,
0.00088571094,
-0.016595596,
0.008865168,
0.020528506,
-0.018890869,
-0.00999991,
-0.00548351,
-0.01760139,
-0.0127207115,
0.016827703,
-0.01111531,
0.03136013,
0.006408711,
0.0022146804,
-0.007414505,
0.0069245026,
-0.00816885,
-0.032778557,
0.0037942922,
0.009303591,
-0.03507383,
0.027491694,
0.014287428,
0.0057414058,
-0.01685349,
-0.0005375516,
-0.007124372,
0.008110823,
0.006560225,
0.0027707682,
0.009374513,
0.0012185577,
-0.029477492,
-0.008665299,
-0.017459547,
-0.01824613,
0.09237828,
0.011830971,
-0.014132691,
-0.014313218,
-0.010638203,
-0.024267996,
0.0013942493,
-0.004094096,
-0.013952164,
0.0049644946,
-0.024667734,
0.003326856,
-0.010612413,
-0.008633062,
0.02123772,
0.011295836,
-0.031669606,
0.025312474,
-0.02279799,
-0.0060218675,
-0.037704367,
0.00601542,
-0.0035235016,
-0.010109516,
0.00013942493,
-0.022488516,
0.019845083,
-0.0075499,
-0.012262946,
0.011605312,
-0.005448049,
-0.0132171605,
0.02094114,
-0.010863861,
0.0049548233,
0.00524818,
0.0011282942,
-0.0038104106,
0.012740053,
-0.02319773,
0.0009421257,
0.0022356345,
0.011805181,
-0.00050491164,
-0.009742014,
0.031850133,
0.019264817,
0.0012298407,
-0.020141663,
-0.0089103,
-0.0020921798,
0.0013055976,
-0.023984311,
0.039097007,
-0.013172029,
-0.015963752,
-0.024783788,
-0.012598211,
-0.009026353,
-0.03566699,
0.023752205,
0.012830317,
-0.0020744496,
-0.0058510113,
-0.0029496835,
-0.1598954,
0.01359111,
0.017588494,
-0.00725332,
0.04007701,
-0.01277229,
0.0058800247,
0.015499539,
0.0113667585,
-0.006540883,
0.018877974,
-0.0050612055,
-0.04123754,
-0.025428528,
0.016002435,
0.0036331073,
0.0036331073,
0.027981697,
0.012495052,
0.008839379,
0.028213803,
-0.026176425,
0.013810321,
-0.01997403,
0.019832188,
0.020954035,
0.01005149,
-0.0038555425,
-0.014132691,
-0.006814897,
-0.021134563,
-0.019355081,
0.023777995,
0.010103068,
0.011018598,
-0.0010751032,
0.008226876,
-0.023584573,
0.003168895,
0.013745847,
0.003562186,
0.019213239,
-0.0036427784,
-0.020206137,
-0.00043681104,
0.008110823,
0.011631101,
0.004255281,
0.014906378,
-0.018349288,
0.021753512,
0.022540094,
-0.0018149419,
0.018568499,
0.03141171,
0.016247436,
-0.005122456,
0.033010665,
-0.0030012627,
-0.0104641225,
-0.0026563269,
-0.02244983,
0.018955342,
0.0039071217,
0.028136434,
-0.008994116,
-0.0043552155,
-0.0017585271,
-0.01752402,
0.0078271385,
-0.014364797,
-0.02255299,
0.029761177,
-0.00140795,
0.022681937,
0.02180509,
-0.006315224,
0.025441423,
-0.004448703,
0.010709124,
-0.011186231,
0.0075241104,
-0.03636331,
-0.041727543,
-0.018890869,
-0.0028932686,
0.014854799,
-0.0017972115,
-0.017317705,
-0.0023532994,
0.006431277,
-0.036131203,
-0.0055415365,
-0.011070178,
0.01005149,
0.016299015,
0.008181745,
-0.008994116,
-0.0034751461,
0.01611849,
0.009806489,
0.0043004127,
-0.009129512,
0.012295183,
0.02713064,
-0.0037040287,
-0.010580176,
-0.0061379205,
0.047917042,
-0.018310603,
-0.007059898,
-0.012875449,
0.014442165,
0.044125974,
-0.019200344,
0.021676144,
0.02653748,
-0.008162403,
-0.00024298622,
-0.011179783,
0.06607291,
0.013874795,
-0.029116439,
0.043017022,
-0.009645304,
-0.041005436,
-0.12575,
-0.027259588,
-0.03203066,
0.041598596,
-0.0005129709,
0.01849113,
0.013204266,
0.028858542,
0.010045042,
0.017446652,
-0.026253793,
-0.013745847,
-0.008239771,
-0.0077691115,
-0.0060025253,
-0.03760121,
0.0058510113,
0.0052094953,
-0.039612796,
0.025931425,
0.024757998,
-0.0055286414,
-0.003529949,
-0.017407969,
0.01515138,
0.021224827,
-0.023584573,
0.021199036,
0.016002435,
0.0037685027,
0.016376384,
-0.00076079264,
0.028110644,
-0.013242951,
0.020657456,
0.0022130685,
0.010315833,
-0.030509075,
0.019638767,
-0.03337172,
-0.021482721,
0.010535045,
0.021095878,
0.013952164,
0.013191371,
-0.015409275,
-0.0175756,
0.008272008,
0.009980568,
0.0074467417,
-0.038607005,
0.0069502923,
-0.047968622,
-0.016066909,
-0.00035662157,
-0.019819293,
-0.0072791097,
0.020773508,
-0.0020937917,
-0.003658897,
0.005460944,
-0.012404789,
0.0144550605,
-0.00078013487,
0.035357516,
-0.021108773,
-0.016776122,
-0.023881152,
0.01700823,
-0.05312654,
0.015834803,
0.0050902185,
0.0065537775,
-0.009464776,
-0.018310603,
0.007646611,
-0.006086341,
-0.014532429,
-0.01685349,
-0.0031640592,
-0.008175298,
-0.014764535,
0.016028225,
0.013732952,
0.014145586,
-0.0037620552,
0.024164839,
0.0024274443,
0.026485901,
-0.011901892,
-0.015344801,
0.028316962,
0.018233234,
-0.02220483,
-0.0153576955,
0.0063281185,
0.0053577856,
0.0015820296,
0.0225272,
-0.0025177079,
-0.025493002,
-0.019239029,
-0.040386487,
0.022114566,
0.007743322,
-0.021663249,
0.0227722,
-0.002591853,
0.009290697,
-0.01685349,
0.018413762,
0.040463854,
0.015035327,
-0.014106901,
0.018504025,
-0.016750334,
-0.045363873,
0.0050579817,
0.01598954,
0.003144717,
0.00816885,
0.02955486,
-0.0057123923,
0.010186885,
0.00834293,
0.020141663,
-0.008078586,
-0.031489078,
0.00030322906,
0.006263645,
-0.021392457,
-0.02279799,
0.011044389,
-0.021598775,
-0.0070341085,
0.0024129378,
-0.022320883,
-0.015267433,
-0.023352467,
0.027233798,
0.0071501615,
0.050779685,
0.0048355465,
-0.016440859,
-0.004171465,
-0.005438378,
0.005215943,
-0.0070663453,
-0.035409097,
-0.0068213446,
-0.0071050297,
-0.001760139,
0.016273227,
0.0070663453,
-0.024809578,
0.0016811583,
0.0041746884,
0.018349288,
0.0023436283,
-0.008207534,
-0.0072662146,
0.00026716394,
0.015783224,
0.020825088,
0.0087878,
0.004190807,
-0.009329381,
-0.019909557,
-0.008362272,
0.005509299,
0.005963841,
-0.034145407,
-0.0061411443,
0.019845083,
0.02965802,
0.015834803,
0.014300323,
0.0055447603,
-0.009864515,
0.00999991,
0.012456368,
0.02769801,
0.01794955,
-0.007156609,
-0.027259588,
0.014700062,
0.024848262,
-0.0041875835,
0.01161176,
0.03569278,
-0.012914133,
-0.009651751,
0.0013370286,
0.030509075,
-0.0004960465,
-0.0070534507,
0.010612413,
0.023159044,
0.00004548436,
0.004297189,
-0.0038845558,
0.023030097,
0.0066923965,
0.014081112,
-0.0003187431,
-0.036750153,
-0.0064860797,
0.010999257,
-0.020837981,
-0.030947499,
-0.02535116,
0.012810974,
-0.003594423,
0.026021687,
0.020309296,
-0.0016521451,
-0.009587277,
0.009535698,
0.013900585,
-0.012224262,
0.0111926785,
0.00896188,
0.026485901,
0.033139613,
-0.005786537,
-0.005141798,
0.007453189,
0.028136434,
0.012727159,
-0.037291735,
0.014674272,
-0.0010331952,
0.025454318,
-0.0018310603,
-0.02836854,
-0.009916094,
-0.009522803,
-0.032185398,
0.002880374,
0.009464776,
-0.021366669,
0.065505534,
0.011476364,
0.0016473095,
-0.00022082329,
0.0013466998,
0.029838545,
0.023171939,
0.018684551,
0.0018745803,
-0.009787146,
0.017794812,
-0.0022420818,
0.0038748847,
-0.031772766,
-0.011031494,
0.016698753,
-0.0070534507,
0.017059809,
0.001268525,
-0.022191934,
0.03584752,
-0.01017399,
0.019716136,
0.016879281,
-0.015331906,
-0.013616899,
0.03628594,
0.0064860797,
0.0037169235,
-0.025015894,
0.016453752,
-0.024022995,
-0.04871652,
0.008645957,
0.0024919184,
-0.025209317,
-0.0036395548,
-0.02589274,
0.02255299,
0.0025338265,
-0.029683808,
-0.0072468724,
-0.01482901,
-0.028858542,
-0.025467211,
0.009683988,
-0.005831669,
-0.013004397,
-0.014519535
] |
To explore the mechanism by which herpes simplex virus (HSV)-2 infection is related to HIV-1 acquisition, we conducted in situ analysis of the cellular infiltrate from sequential biopsies of HSV-2 lesions from patients on and off antiviral therapy. CD4(+) and CD8(+) T cells and a mixed population of plasmacytoid and myeloid dendritic cells (DCs), including cells expressing the C-type lectin receptor DC-SIGN, persisted at sites of HSV-2 reactivation for months after healing, even with daily antiviral therapy. The CD4(+) T cells that persisted | [
-0.014502485,
0.007974377,
0.00946045,
-0.033144746,
-0.010701057,
0.003565913,
0.010276464,
-0.0020765224,
-0.0070920205,
-0.013998282,
0.015351671,
0.010827107,
-0.02456002,
0.006279324,
-0.023458732,
0.0027067768,
0.040230133,
0.015497624,
-0.005506433,
-0.019186271,
-0.044874113,
-0.00016191733,
0.009075663,
-0.033542804,
-0.0099580195,
0.015617041,
0.021707289,
-0.035931136,
-0.020751955,
0.004474806,
0.006912896,
-0.010103974,
-0.0028228764,
0.0052244775,
-0.0041099223,
-0.017567512,
0.018735142,
-0.017089846,
0.009938117,
0.027120842,
0.0018774947,
0.004368658,
-0.010037631,
-0.0055860444,
0.012100885,
-0.0045909057,
-0.00037587213,
-0.024759047,
-0.008996053,
0.016466226,
0.026775861,
-0.010900084,
-0.00529082,
0.0022208176,
-0.019186271,
-0.02456002,
0.013155731,
0.012505574,
0.0028295105,
-0.03688647,
0.0064153266,
-0.0068067475,
-0.011948297,
0.02456002,
-0.0040336284,
0.017965568,
-0.000237382,
0.01679794,
0.009792163,
0.02722699,
0.019080123,
0.021282697,
-0.018310549,
0.009294594,
0.024705973,
-0.005393651,
-0.010190219,
-0.018297281,
0.005211209,
0.0067802104,
0.019186271,
-0.023418928,
-0.0076559326,
0.028553842,
-0.0024198452,
0.003136345,
0.020460049,
0.02161441,
0.015603772,
-0.008498483,
-0.0046804682,
0.009447182,
-0.003798112,
0.037098765,
-0.014927078,
0.022105344,
-0.0058248774,
0.028023101,
0.0016030023,
-0.0004656419,
-0.017647123,
-0.00553297,
-0.009672747,
-0.023498539,
-0.018456502,
0.02141538,
0.014170772,
0.0062096645,
0.017036771,
-0.008538289,
-0.03043797,
0.022357445,
-0.0017514438,
-0.05020806,
0.0075033447,
0.01597529,
0.0045544174,
-0.0068266504,
-0.015882412,
-0.007622761,
0.0014504144,
0.013918671,
0.017036771,
-0.015033226,
0.03311821,
0.0132419765,
-0.0060802964,
-0.0095997695,
0.0053206743,
-0.010959793,
0.02722699,
0.020022187,
-0.0084056035,
0.00088650256,
0.007529882,
0.0048131533,
-0.015073032,
-0.014436143,
-0.011132283,
-0.016532568,
0.016678521,
0.04375956,
0.013560421,
-0.009659478,
0.0015830996,
0.017633855,
0.030305285,
-0.0001802652,
-0.0058978545,
-0.000036358837,
-0.0038080635,
-0.033967394,
0.014887272,
-0.026404344,
-0.0060504423,
0.0017215897,
-0.012114153,
0.02392313,
-0.016824476,
-0.01659891,
-0.015789531,
-0.010667885,
0.02759851,
0.013799255,
-0.003345324,
0.022927992,
0.011556876,
0.014834198,
0.0053836997,
-0.019411836,
-0.020380437,
0.029403027,
-0.020367168,
0.014422875,
-0.014130968,
0.0028543891,
0.0022490132,
0.021494992,
-0.016134514,
-0.041928504,
-0.0112716025,
0.019252613,
0.025661306,
-0.0134211015,
-0.018443234,
-0.004003774,
0.027280064,
-0.01999565,
-0.0042790957,
-0.0066276225,
-0.009201715,
0.009095566,
-0.013069486,
-0.016771402,
-0.6445313,
-0.028978433,
0.025926676,
0.006405375,
0.021800168,
0.01544455,
0.02044678,
-0.00075962243,
-0.022025732,
0.022636084,
0.0034398623,
0.009354303,
0.009997825,
-0.006999141,
-0.007490076,
-0.02205227,
-0.004700371,
0.005957563,
0.017779808,
0.0066176713,
-0.0103162695,
-0.0077023725,
0.008916441,
0.020022187,
0.017235799,
0.0001933264,
0.04338804,
-0.025289787,
-0.003688647,
0.026417611,
-0.022609547,
0.016837744,
-0.0020881323,
-0.013905402,
0.047899336,
-0.0066641113,
-0.0028958532,
0.03266708,
0.01151707,
0.027916953,
-0.008830196,
-0.006302544,
0.012087616,
0.009520159,
-0.020632539,
0.012790848,
-0.03168521,
0.019000512,
0.016996967,
0.0018625676,
0.0103759775,
0.007151729,
-0.015988559,
0.0018327135,
0.024254844,
-0.014064625,
0.01307612,
-0.023020871,
0.010276464,
0.013467542,
0.011337945,
0.0091022,
-0.0007206462,
-0.04044243,
0.00039100653,
0.0071649975,
-0.023856789,
0.007198169,
0.020035457,
0.014104431,
0.017209262,
0.03338358,
0.00627269,
0.014648439,
-0.00027718756,
0.013547152,
-0.0010797253,
-0.009559964,
-0.010143779,
0.004305633,
-0.010163682,
-0.014621902,
-0.0095997695,
0.00091718603,
-0.0005386187,
-0.017381754,
-0.026205314,
0.024931537,
-0.017633855,
0.014157504,
0.016917355,
0.020406974,
-0.011954931,
-0.03919519,
-0.0056391186,
0.036037285,
-0.006196396,
-0.0010921645,
-0.02161441,
0.0062096645,
0.0039672856,
-0.017275605,
0.020234484,
0.0009329424,
0.023644492,
0.0004169216,
-0.04949156,
-0.0025823845,
0.0576915,
-0.029111119,
-0.0043819267,
-0.013971745,
-0.0069593354,
0.0060305395,
0.017275605,
-0.019133197,
0.009792163,
0.0052642827,
-0.011709464,
-0.022158418,
0.022529937,
0.018323818,
-0.025608232,
-0.013162366,
0.017753271,
0.01383906,
-0.0067304536,
-0.015869142,
0.0049989126,
-0.011696195,
-0.0014587073,
-0.018522846,
0.019849697,
-0.011430825,
0.010210121,
-0.0048363735,
0.025210176,
-0.0053339424,
-0.009931482,
-0.037974488,
-0.025860334,
0.004305633,
0.004959107,
0.016917355,
0.0038014292,
0.00072935363,
0.0069062617,
0.015829338,
-0.0048662275,
-0.018708605,
0.029058045,
-0.022330908,
0.0054898476,
0.014303458,
0.015776264,
-0.010070802,
0.011324677,
-0.015816068,
0.019385299,
-0.004398512,
-0.009652844,
0.029323416,
0.030597193,
0.008976149,
0.0062892754,
0.009049127,
0.017594049,
0.009951386,
0.01768693,
-0.03319782,
-0.0013144121,
-0.0137196435,
-0.0024994563,
0.016399883,
0.011072575,
-0.00008997711,
-0.015683383,
-0.0076758354,
-0.022927992,
0.02286165,
0.018496308,
-0.008942978,
0.012532111,
0.006614354,
0.037894875,
-0.00591444,
0.012910264,
0.0032026875,
0.019982383,
0.021919586,
-0.003741721,
-0.0019521301,
0.0022357446,
0.004096654,
-0.00495579,
-0.016625447,
-0.0035559617,
0.00653806,
0.009161909,
0.022742232,
0.0013517299,
-0.012532111,
-0.00008064769,
-0.012890361,
0.015112837,
-0.014290189,
-0.003844552,
-0.036727246,
0.05214526,
-0.0067039165,
0.020619271,
-0.005015498,
-0.0031197593,
0.011377751,
-0.03179136,
0.008856733,
0.0039208457,
0.0077421777,
-0.0063323984,
0.0060968823,
-0.009188446,
0.014343264,
0.019252613,
-0.028315008,
0.00048554468,
0.009659478,
0.004179582,
0.010575006,
-0.006037174,
-0.008485215,
-0.010190219,
-0.015338402,
0.025900139,
0.024148695,
0.003612353,
0.0047633965,
0.015656846,
-0.00056100934,
0.012817385,
0.007437002,
0.005582727,
0.03287938,
-0.017089846,
0.0027797536,
-0.003045124,
-0.0011178723,
0.018973975,
0.018284012,
-0.014754588,
0.012359621,
-0.0047899336,
-0.0103162695,
0.002360137,
-0.013135829,
0.00593766,
-0.009221617,
0.0050752065,
0.017395021,
0.032242488,
0.019969113,
-0.0013392906,
-0.0067205024,
0.0124657685,
-0.020367168,
-0.0038644546,
0.00785496,
-0.019239346,
-0.013547152,
-0.021322502,
0.013348125,
-0.014091162,
-0.0128240185,
0.006614354,
-0.020075262,
-0.000014149626,
0.023578148,
-0.0061267363,
-0.0008574777,
0.009944751,
-0.0021146694,
-0.014356532,
-0.02365776,
0.01214069,
0.0052078916,
0.0034299109,
-0.019265883,
0.0011734342,
0.0062395185,
0.007722275,
-0.004776665,
0.006999141,
0.011410922,
0.016678521,
-0.0011120674,
-0.007662567,
-0.013586958,
0.024984611,
-0.0013069486,
0.011258334,
0.016200855,
-0.005858049,
0.0029704885,
-0.020221215,
-0.017434828,
0.04001784,
-0.010999598,
-0.003741721,
-0.014940347,
-0.034232765,
-0.026298195,
0.024626361,
-0.0037151838,
-0.0074701733,
-0.0024646265,
0.01740829,
0.023617955,
-0.0076028584,
0.003897626,
0.015749726,
0.005811609,
-0.011755903,
-0.035108488,
-0.0039938227,
-0.03285284,
0.024414066,
0.030411433,
-0.022702428,
0.01945164,
0.015391476,
0.02152153,
-0.00653806,
-0.019000512,
0.02284838,
-0.029058045,
0.012087616,
-0.001543294,
-0.0072711455,
0.003642207,
0.031924043,
0.02900497,
0.0021876462,
-0.0027731194,
-0.0023153557,
0.01044232,
-0.0095997695,
-0.010906719,
0.004219387,
0.04712976,
0.020115066,
-0.014038088,
0.012598454,
0.019053586,
-0.0029522444,
-0.011172089,
-0.013759449,
0.011729366,
0.0062395185,
0.028023101,
-0.013547152,
-0.037921414,
-0.00264541,
0.022622816,
0.0022473545,
0.0026818984,
0.019491447,
0.031021785,
0.008372433,
0.0032756643,
-0.0019272517,
0.0018393478,
-0.0030318554,
0.025701111,
-0.0052841855,
-0.024971344,
0.025780722,
-0.016651984,
0.0024480408,
-0.012439231,
-0.0028179006,
-0.00852502,
0.0065446943,
-0.0069792382,
-0.013288417,
0.0035957673,
-0.012008005,
-0.011318042,
0.017275605,
-0.014635171,
-0.033012062,
0.0031297107,
-0.018589187,
-0.0049524726,
-0.013693106,
-0.017249068,
-0.0017829565,
-0.020128336,
-0.020247752,
0.013666569,
-0.003980554,
0.010568371,
0.0060239052,
0.0032507859,
0.00036820126,
0.024360992,
-0.010973061,
-0.016280467,
-0.0042028017,
-0.024122158,
0.011802343,
0.011762538,
-0.015948754,
0.00032279806,
-0.008206576,
0.010097339,
0.0103759775,
0.00052783807,
-0.007350757,
-0.0026338,
0.0031529306,
0.024069084,
0.022065539,
0.014369801,
-0.0210704,
-0.0043951953,
-0.010740862,
-0.05848761,
0.0057651694,
-0.010946524,
-0.024440603,
-0.01482093,
-0.0015723188,
0.010754131,
-0.014276921,
-0.019199539,
0.022198224,
-0.024613094,
-0.008830196,
-0.0099580195,
0.032454785,
0.03179136,
-0.0038710888,
0.0004109093,
0.010926621,
-0.017262336,
-0.004929253,
-0.0026238486,
0.014728051,
-0.023684297,
-0.0049889614,
0.016625447,
0.010614811,
-0.009579867,
-0.019345494,
-0.02071215,
-0.015762994,
0.022105344,
-0.0038379177,
-0.016877549,
-0.023140289,
0.003847869,
0.0077421777,
0.0023966252,
0.03598421,
-0.017554244,
0.0020715466,
0.008246382,
-0.013640032,
-0.022025732,
0.02884575,
-0.033781637,
-0.007828423,
0.031260617,
0.00459754,
-0.0049458384,
0.005828195,
-0.0045378315,
-0.0011029452,
0.009705918,
-0.027492361,
-0.016373346,
0.00264541,
0.0012497281,
0.03760297,
0.016731596,
0.031764824,
-0.0016552471,
-0.0010606518,
0.010342807,
-0.0017962251,
0.012173861,
-0.0076293955,
0.024944806,
-0.013341491,
0.018323818,
-0.0065977685,
0.0006227909,
0.0042227046,
-0.014077893,
0.01695716,
0.017793078,
-0.00902259,
-0.02767812,
-0.011994736,
-0.021150012,
-0.021004057,
-0.008000914,
-0.007821789,
0.0074303676,
-0.044582207,
-0.0053074057,
0.013149098,
-0.00051539886,
0.0030517583,
0.0061333706,
0.033171285,
-0.008093794,
0.014276921,
-0.018801484,
-0.016134514,
0.008372433,
-0.007065484,
-0.0004714469,
-0.004418415,
0.022821844,
-0.00072935363,
-0.016824476,
0.026430879,
-0.0008027451,
0.0077554462,
0.020393705,
-0.010986329,
-0.04187543,
-0.018164596,
-0.020115066,
-0.022556474,
-0.018960707,
-0.032614008,
-0.006601086,
-0.022981066,
-0.016904086,
-0.00234521,
0.008372433,
-0.0152720595,
0.0033818125,
0.03741721,
-0.009214983,
0.021189816,
-0.035400394,
0.029668396,
0.026417611,
-0.0005315698,
-0.035294246,
0.0030152698,
0.002492822,
0.004823105,
0.045855984,
0.04251232,
-0.016200855,
-0.01661218,
0.027439287,
0.013706375,
0.026616639,
-0.02794349,
0.0116298525,
0.029243805,
-0.005134915,
-0.023246435,
-0.018323818,
-0.04296345,
0.012790848,
-0.017872687,
0.0070588496,
-0.0071583632,
0.0035924502,
-0.011815611,
0.03115447,
-0.0048960815,
0.01589568,
0.00019778378,
-0.015922217,
-0.023379121,
-0.051402222,
0.014529022,
-0.0005958392,
-0.014860735,
0.006660794,
-0.022105344,
-0.007967742,
0.009347668,
-0.009281325,
-0.00034974972,
0.008710779,
-0.017461365,
0.040230133,
-0.008432141,
0.000060744915,
0.0058680004,
-0.004312267,
0.0023667712,
0.00069949945,
0.005440091,
0.0009777236,
-0.041105855,
-0.010608177,
0.037682578,
0.021295965,
-0.0060968823,
0.0113313105,
-0.017421558,
-0.0019819844,
-0.018682068,
-0.022782039,
0.011430825,
-0.033357043,
0.001199142,
-0.008107062,
-0.003174492,
0.026775861,
0.016545836,
0.00011568485,
-0.0033702026,
0.021893049,
-0.03216288,
0.01624066,
0.013056218,
0.020327363,
-0.01804518,
-0.005605947,
-0.0059177573,
-0.029694933,
0.0047899336,
0.009088932,
-0.02651049,
-0.040283207,
-0.009115469,
-0.0020881323,
0.0034929363,
-0.015285328,
0.016373346,
0.0052012573,
0.0015068057,
0.005645753,
-0.010488761,
0.033012062,
-0.017381754,
-0.015882412,
-0.009798798,
-0.047872797,
-0.008107062,
0.017580781,
0.0225034,
-0.0032988843,
-0.026550297,
-0.013281782,
-0.017209262,
-0.0077156406,
-0.012114153,
-0.0062362016,
0.00087986834,
-0.0031114665,
-0.012459135,
-0.010986329,
0.021282697,
-0.029111119,
-0.024175232,
-0.0028991704,
-0.0033735198,
0.009268057,
-0.0074967104,
0.006166542,
-0.0076758354,
-0.0490935,
-0.00986514,
-0.006063711,
-0.034790043,
0.026125703,
0.009500256,
0.007072118,
-0.01348081,
-0.011397653,
-0.04471489,
-0.0011352872,
0.004391878,
-0.015749726,
0.0103759775,
0.02741275,
-0.02284838,
-0.0045345146,
-0.010263195,
0.04115893,
-0.009062395,
-0.016373346,
0.027704656,
-0.0014421216,
0.01803191,
0.009082298,
-0.017222531,
-0.016267197,
0.026192047,
-0.0037549895,
0.008020816,
0.0134211015,
-0.011132283,
-0.0036554756,
-0.00593766,
0.0151526425,
0.002048327,
0.010515297,
-0.00027387042,
-0.026895277,
-0.0037881606,
0.01034944,
-0.009772261,
-0.016214125,
-0.01980989,
-0.0006165712,
0.0045643686,
-0.0031064907,
0.009168543,
-0.031658676,
0.024652898,
-0.022808576,
0.0073905624,
-0.0026056045,
-0.017063309,
0.0077023725,
0.009785529,
-0.009473719,
0.005678924,
0.015617041,
-0.028023101,
-0.011046038,
0.0094206445,
-0.0056523867,
-0.0101968525,
-0.006378838,
0.006557963,
-0.015431281,
0.015378208,
0.010157048,
0.0027183867,
-0.035108488,
0.030331822,
0.0048164707,
-0.025210176,
-0.003212639,
0.002942293,
0.00069120666,
-0.017660392,
-0.010342807,
-0.001581441,
0.010289732,
-0.012605088,
-0.015855875,
0.0038312834,
0.0044051465,
-0.014953615,
-0.0051249634,
-0.017103115,
-0.017368484,
0.19573712,
-0.009991191,
0.010243293,
-0.0019554473,
-0.016771402,
0.01218713,
0.029774545,
0.00428573,
0.02356488,
0.009473719,
0.025913408,
-0.005685558,
0.0068996274,
-0.009520159,
0.007310951,
-0.0054566762,
-0.005685558,
-0.0044549033,
-0.0014114382,
-0.029854156,
0.018854558,
-0.0013135829,
0.028925361,
-0.0084653115,
0.02499788,
-0.017753271,
-0.037921414,
-0.00031740774,
0.0010390904,
0.012877093,
-0.026032824,
-0.003391764,
-0.005811609,
0.0049458384,
0.012658162,
-0.00830609,
-0.010130511,
-0.014648439,
0.013069486,
-0.0064650835,
0.009069029,
-0.02348527,
-0.042034652,
0.008916441,
-0.015670115,
0.021375576,
0.009878408,
-0.0217869,
-0.017594049,
0.013560421,
-0.037337597,
-0.026377806,
0.003159565,
0.0057718037,
-0.007914669,
-0.005838146,
0.041955043,
0.0093609365,
-0.02794349,
0.03096871,
-0.015073032,
0.0016759791,
-0.02919073,
0.02865999,
0.000040790314,
0.01980989,
-0.0067503564,
-0.008140233,
0.0014296824,
-0.014436143,
0.038452152,
-0.015285328,
-0.024825389,
-0.009367571,
-0.010853644,
-0.0055661416,
0.013653301,
0.0014172432,
0.023060678,
0.008763853,
0.008452043,
0.0116298525,
-0.0068067475,
0.03526771,
-0.0023734055,
-0.026205314,
0.021733826,
0.0128240185,
-0.01715619,
0.016267197,
0.00825965,
-0.014741319,
-0.0067702592,
-0.0037317695,
0.011835515,
0.012432598,
-0.005088475,
0.0043653413,
0.014396338,
-0.010303001,
-0.040601652,
0.08422852,
0.027731193,
-0.01767366,
-0.0061267363,
0.0030882466,
-0.0072910483,
0.0012712895,
0.0008342578,
-0.035506543,
0.024599824,
-0.015325134,
0.008087159,
-0.0057684863,
-0.006498255,
0.024905,
0.0006227909,
-0.019438373,
0.018164596,
0.016943892,
0.012737773,
-0.028394619,
-0.004103288,
0.016917355,
-0.025342861,
-0.0155108925,
-0.03428584,
0.0039672856,
0.0005203745,
-0.025369398,
0.007908034,
-0.0035261076,
-0.0070389467,
0.039487097,
0.022158418,
0.0026968254,
0.013985014,
-0.017753271,
-0.028606916,
-0.0075630527,
-0.005450042,
-0.008060622,
0.031260617,
-0.0075829555,
0.0065911342,
-0.016758133,
0.015617041,
0.03598421,
-0.023777178,
-0.006348984,
-0.0015159277,
-0.02142865,
0.0037151838,
-0.0145555595,
0.008279553,
-0.03571884,
-0.022039002,
-0.005154818,
-0.0038080635,
0.011802343,
-0.008445409,
0.016665254,
0.010183584,
-0.026112435,
-0.014767856,
-0.0007318415,
-0.16675869,
0.019571058,
0.008677608,
-0.0029290244,
0.043706484,
0.012784213,
0.0073374882,
0.017169457,
-0.0031910776,
0.041663133,
0.020128336,
0.011716098,
-0.02580726,
0.0010565054,
0.0077886176,
0.0022158418,
-0.011530339,
0.041477375,
0.044078004,
0.002462968,
0.030544119,
-0.0330386,
-0.005741949,
-0.021587873,
0.017434828,
0.0015656847,
-0.006640891,
0.001510952,
-0.0046141255,
-0.0029074631,
0.00857146,
0.021282697,
0.04179582,
-0.019080123,
0.015617041,
-0.0130628515,
0.00486291,
0.0052045747,
0.0026022873,
0.020022187,
0.043706484,
-0.015550698,
0.009752357,
-0.014329995,
-0.025913408,
0.0075033447,
-0.0018244206,
-0.0055926787,
0.0059277085,
0.013142463,
0.031234082,
0.00027532165,
0.013878865,
0.017023504,
0.012658162,
0.006402058,
0.0046373457,
0.0070588496,
0.011198626,
0.019491447,
0.012432598,
-0.008233113,
0.026377806,
-0.004650614,
0.009188446,
-0.05126954,
0.00433217,
0.0029721472,
-0.014091162,
0.023379121,
-0.032534394,
0.0006837431,
0.0077156406,
-0.023830252,
0.015364939,
0.021481724,
-0.026271658,
0.019133197,
0.006999141,
-0.0019935942,
0.0036355727,
0.015431281,
-0.023259705,
-0.0047434936,
-0.024082353,
-0.0008462824,
0.0009901628,
0.0057651694,
0.020460049,
-0.003456448,
-0.009294594,
-0.039168652,
0.008491849,
-0.010820473,
0.0042989985,
0.039779004,
0.015431281,
-0.000016054384,
-0.011550241,
0.014157504,
0.01642642,
-0.0017398339,
-0.025754185,
0.011676292,
-0.009108835,
-0.011968199,
-0.0131822685,
0.0041132392,
0.03277323,
0.0027581924,
-0.036541488,
0.020420242,
0.022291103,
0.022224762,
0.002360137,
0.029986842,
-0.005678924,
0.00083259924,
0.016678521,
-0.021999195,
0.057744574,
0.013732912,
-0.024759047,
0.011603315,
-0.0065214746,
-0.02125616,
-0.14192003,
-0.014263652,
0.0022108662,
-0.008385701,
-0.006425278,
0.032083265,
-0.000896454,
0.0023070627,
-0.013487444,
0.019557789,
-0.03553308,
-0.015404745,
-0.006839919,
-0.010608177,
0.0054832133,
0.013036315,
-0.0015723188,
0.009208349,
-0.025289787,
0.02660337,
0.0046373457,
-0.0013235343,
-0.003897626,
-0.015112837,
0.022914723,
0.000432056,
-0.025249982,
0.024613094,
0.023909861,
0.025966482,
0.010780668,
-0.0011352872,
0.01768693,
0.0059542456,
-0.019690474,
-0.007078752,
-0.01182888,
-0.0070588496,
0.021043863,
-0.025462277,
-0.0057154126,
0.014887272,
0.0064684004,
0.008697511,
0.0077355434,
0.010143779,
-0.015311865,
-0.0021594507,
0.016651984,
-0.022025732,
-0.020406974,
-0.016877549,
-0.032215953,
-0.0256215,
0.005675607,
-0.0072711455,
0.007310951,
0.027465824,
-0.012916898,
-0.022795307,
-0.0032142976,
-0.000480569,
-0.016917355,
0.02544901,
0.023949668,
-0.010634714,
-0.008173404,
-0.0006028881,
0.016346809,
-0.035851523,
-0.0011651414,
-0.028500767,
-0.019133197,
-0.008299455,
-0.01218713,
0.02177363,
0.006866456,
-0.022437057,
-0.0020682295,
-0.01659891,
-0.015696652,
-0.009686016,
0.026311463,
0.011503802,
0.040840484,
-0.014210578,
0.0047633965,
0.0020533025,
0.002572433,
0.007310951,
-0.0068067475,
0.052676,
0.003688647,
-0.022370715,
-0.018960707,
0.0049193017,
-0.0323221,
0.003383471,
0.006116785,
0.0146749765,
-0.016028365,
0.0099580195,
-0.048589297,
0.010740862,
-0.003330397,
-0.014436143,
0.010820473,
0.0022257932,
-0.0027349724,
-0.022715695,
-0.012525477,
0.018310549,
-0.017952299,
0.0050553037,
-0.025780722,
0.0378418,
-0.023193363,
-0.018589187,
0.020672346,
-0.027041232,
0.004544466,
0.028500767,
0.0041132392,
-0.008272918,
0.010163682,
0.0210704,
-0.009188446,
0.020977521,
0.007961108,
0.0189209,
-0.01695716,
0.0045643686,
0.0019090074,
-0.02588687,
-0.0019173003,
0.009155274,
-0.0047998847,
-0.007536516,
0.014077893,
0.033542804,
0.018244207,
0.04190197,
-0.0316056,
-0.038690988,
-0.0053836997,
0.005287503,
-0.02402928,
0.0057154126,
-0.035745375,
0.017925762,
-0.008531654,
-0.017487902,
0.0356923,
0.01616105,
-0.0155108925,
-0.03274669,
-0.008471946,
0.009400742,
-0.0027548752,
-0.017885957,
-0.009739089,
-0.019557789,
0.010720959,
0.013580324,
0.0091818115,
0.0112517,
-0.0017580781,
-0.018191133,
-0.029084582,
0.0044283667,
-0.015378208,
0.007072118,
-0.02141538,
0.007529882,
0.0013301686,
0.0059078056,
-0.010979695,
0.0031612234,
-0.01740829,
-0.00036135968,
-0.0068266504,
0.009394107,
0.007596224,
-0.016771402,
-0.0045643686,
-0.0021345722,
0.035135023,
0.010117242,
0.0048662275,
0.035745375,
0.0057253637,
0.0032856157,
0.0068332846,
0.011191991,
0.045166023,
-0.001587246,
0.012724505,
0.008107062,
-0.011596682,
0.011742635,
0.021548066,
0.02526325,
0.0024032595,
0.01750117,
0.007874863,
-0.020460049,
0.0042890473,
0.026430879,
-0.032269027,
-0.050128445,
-0.02214515,
0.005469945,
0.00022307689,
0.0042724614,
-0.0046605654,
-0.010011094,
-0.022397252,
-0.0139584765,
0.0008939661,
0.015882412,
-0.018005373,
0.021972658,
-0.00564907,
0.03277323,
0.001128653,
-0.0012372889,
0.018522846,
-0.0074768076,
0.023604685,
-0.012034542,
0.01679794,
0.0053803823,
0.012923532,
0.0038644546,
-0.024135428,
0.0019421787,
-0.015948754,
-0.03096871,
0.009234886,
0.02125616,
-0.0122269355,
0.07048234,
0.009831969,
-0.019385299,
-0.018483039,
-0.04590906,
-0.00392748,
0.012804116,
0.00812033,
0.0048164707,
-0.027359676,
0.022583012,
-0.014051356,
0.04190197,
-0.03492273,
-0.02722699,
0.0026172143,
-0.0034000566,
-0.012883727,
-0.011709464,
0.005894537,
-0.0014155846,
-0.0014388044,
-0.00032196878,
0.0023966252,
-0.02437426,
-0.0009744065,
-0.0012389475,
-0.027465824,
-0.014781125,
-0.0308891,
0.009672747,
-0.019756816,
-0.058434535,
-0.019438373,
-0.012651528,
-0.029615322,
-0.030384896,
-0.018018642,
0.0068001132,
0.017288873,
-0.029509176,
0.0032623957,
-0.012253473,
-0.010395881,
-0.0056722895,
-0.021388844,
-0.027704656,
-0.021004057,
0.01254538
] |
We conducted a two-stage population-based headache survey among subjects aged > or = 15 in Taipei, Taiwan. Subjects with chronic daily headache (CDH) in the past year were identified, interviewed and followed-up. CDH was defined as a headache frequency > 15 days/month, with a duration > 4 h/day. Of the 3377 participants, 108 (3.2%) fulfilled the criteria for CDH, with a higher prevalence in women (4.3%) than men (1.9%). TM was the most common subtype (55%), followed by CTTH (44%). Thirty-four per cent of the CD | [
0.009158017,
0.018960588,
0.019551428,
-0.04605865,
-0.0026822786,
-0.0015484368,
-0.009272157,
-0.00057992944,
-0.0075063515,
-0.0027594906,
-0.011823511,
0.02233106,
0.0148515655,
0.005941969,
-0.018235466,
0.02114938,
0.03193221,
0.0017758766,
-0.001112021,
-0.0138041675,
-0.026883213,
0.0023633593,
0.0034980404,
0.0067543737,
-0.0076406333,
0.026077522,
0.015818395,
-0.023432171,
0.0048442152,
-0.027876899,
0.00825833,
-0.0033922936,
-0.016274951,
0.0036491074,
-0.016113814,
0.0063582426,
0.0051497063,
0.004307088,
0.021431372,
-0.0025698177,
0.023391886,
-0.011481092,
0.00873503,
0.0044782977,
0.0026134592,
0.016355522,
0.010635117,
-0.032012776,
-0.0033570447,
0.025889527,
0.01894716,
0.024788417,
-0.028333455,
0.021243379,
-0.0015333301,
-0.0012169287,
-0.007009509,
0.015509546,
0.0074123545,
-0.04525296,
-0.023754448,
0.0064992383,
-0.01879945,
-0.0013889772,
-0.01569754,
-0.0152812665,
-0.019484287,
0.0018614812,
0.014663571,
-0.002009191,
0.025312116,
0.017376063,
-0.01146095,
-0.028038036,
0.038834292,
-0.022075925,
-0.0068080863,
-0.031797927,
-0.0066670906,
-0.0018295893,
0.021109097,
-0.014099587,
-0.026440082,
0.010702258,
-0.006700661,
0.0077279164,
-0.010279271,
0.005367914,
-0.012736627,
-0.009681717,
-0.028924296,
-0.011199101,
0.002480856,
0.015563259,
0.014032446,
0.026601221,
0.0035248967,
0.01709407,
-0.0119645065,
-0.011138674,
-0.03418814,
-0.0038807434,
-0.007378784,
-0.018410033,
-0.017456632,
-0.0048811426,
-0.003769961,
-0.0021669723,
-0.0010045955,
-0.023848444,
-0.020598825,
0.037921175,
-0.0043574437,
-0.016234668,
-0.022962185,
-0.0092587285,
0.0056633344,
-0.012642629,
0.014757568,
-0.024291575,
0.021793934,
-0.00058454537,
0.019578284,
0.00039319386,
0.011031249,
0.025271831,
-0.032603618,
-0.020921102,
0.022505626,
-0.003622251,
-0.031421937,
0.007143791,
0.045011252,
0.005485411,
-0.012951478,
0.012374066,
-0.021471657,
0.00017530067,
-0.03840459,
-0.0079024825,
-0.010581405,
0.02623866,
-0.017067214,
-0.00600911,
0.015952677,
0.03996226,
0.041117083,
0.009252015,
0.006529452,
0.0048140017,
-0.008184475,
0.00060300913,
-0.007875627,
0.018316034,
0.0014032447,
0.014260725,
0.009903281,
0.016315237,
-0.0087686,
-0.012152501,
-0.014139872,
-0.0055592656,
0.025070408,
-0.002150187,
0.00414595,
0.013925021,
-0.010682115,
-0.0107291145,
0.019269437,
-0.005344415,
-0.012488206,
0.014247297,
-0.021444801,
-0.0053981277,
0.020155696,
0.013515461,
-0.0007704417,
0.0041963058,
-0.029380854,
-0.037169196,
-0.03966684,
0.01139381,
0.020101983,
-0.0065193805,
-0.021713365,
0.000763308,
0.014717284,
-0.0013780668,
0.008399325,
-0.0038807434,
-0.0053410577,
0.02541954,
-0.004965069,
-0.00467972,
-0.642404,
-0.0031354795,
-0.016664369,
-0.008419468,
0.013925021,
0.014690427,
0.009943566,
0.015643828,
-0.02919286,
0.011413951,
0.007862198,
0.016919505,
0.022693621,
-0.0067342315,
-0.0077950573,
-0.011736228,
-0.021404516,
0.001767484,
-0.017483488,
0.0136228865,
-0.005572694,
0.0034308995,
-0.026695218,
0.024546709,
0.0043305876,
-0.015966104,
-0.0040922374,
-0.014099587,
-0.008365755,
0.023861872,
-0.0107291145,
0.020451115,
-0.00075281726,
0.009990565,
0.03966684,
-0.03912971,
-0.008130762,
0.031207087,
0.011078247,
0.022720478,
-0.009399725,
-0.0039579556,
0.03037454,
0.005069137,
-0.008345612,
0.008204617,
-0.0059889676,
0.0024607137,
0.031341366,
-0.017953474,
0.014045875,
-0.015522974,
0.0039378135,
-0.0014519218,
-0.0009147946,
-0.023821589,
0.011447522,
-0.01234721,
0.0022643267,
-0.003971384,
0.0016827186,
0.012065218,
0.0012463027,
0.01835632,
-0.021767076,
-0.0010725757,
-0.0020612255,
-0.011239385,
-0.0015836857,
-0.008520179,
-0.0019940846,
0.0077883434,
-0.0051698484,
-0.0047032195,
0.025285259,
0.019511143,
0.032818466,
0.0040250965,
-0.02771576,
-0.0033268312,
0.012964906,
0.0005312523,
0.0019739422,
0.020303406,
0.03193221,
-0.025835816,
-0.032227628,
0.009963708,
-0.021968499,
-0.0052504176,
-0.0052537746,
0.010614975,
0.010030849,
-0.012723199,
-0.021793934,
0.023459027,
-0.012118931,
-0.010279271,
0.015160413,
0.0017423062,
-0.022210207,
-0.009426581,
0.00085394824,
0.0003772479,
0.0180609,
0.01160866,
-0.031180229,
-0.0087618865,
0.0595674,
-0.0044111568,
-0.005945326,
-0.004673006,
-0.016932933,
-0.005737189,
0.023244176,
-0.017886333,
0.02498984,
0.002400287,
-0.008741744,
-0.019645425,
0.0077816295,
0.009426581,
0.020800248,
-0.03397329,
0.009849569,
0.028279744,
-0.006552951,
0.0017926618,
-0.006630163,
-0.011293098,
-0.0065361657,
0.0050959936,
0.021726793,
-0.016086958,
0.024815273,
-0.0087686,
0.017188068,
-0.025929812,
0.010030849,
-0.033651013,
0.0014376544,
0.015254411,
0.005354486,
-0.007338499,
-0.0019319791,
-0.016167527,
0.0005941969,
-0.024654135,
-0.0004473262,
-0.0034846123,
0.02085396,
-0.028226031,
0.0033033318,
0.0034879693,
-0.011924222,
-0.017886333,
0.023163607,
-0.030401396,
-0.006566379,
-0.013669886,
0.004427942,
0.004740147,
-0.02131052,
-0.007526494,
-0.0059218267,
-0.02085396,
-0.0037464618,
0.030535677,
0.00050145853,
-0.026426654,
-0.0023230747,
-0.0041862344,
-0.0034409708,
0.025177835,
0.0022089353,
0.009983851,
0.011360239,
-0.041170795,
-0.0049885684,
-0.013763883,
-0.0046830773,
0.003098552,
-0.00615682,
-0.020746535,
0.011991363,
-0.013911593,
0.00921173,
-0.003766604,
0.007472781,
0.04157364,
-0.005807687,
0.01732235,
-0.041895915,
-0.0015089916,
0.01952457,
0.00067728374,
0.010849968,
0.005800973,
0.009460151,
0.01679865,
0.038350876,
0.008600748,
-0.010588119,
0.016019817,
0.034966975,
-0.027030922,
-0.0048375013,
-0.009923424,
0.026332658,
-0.010373267,
-0.0034913262,
-0.016704654,
0.009648146,
-0.0005581087,
-0.023311317,
0.03743776,
-0.013381179,
-0.005421627,
-0.011299812,
0.004068738,
0.007687632,
-0.014099587,
0.019725993,
0.013240184,
0.006556308,
0.028790014,
0.02063911,
0.00807705,
0.019350005,
-0.0120853605,
-0.0022290775,
0.0063045295,
-0.0107895415,
0.027084636,
0.00873503,
0.0064488826,
0.010520978,
-0.020370547,
0.01569754,
0.027984323,
0.0011934293,
0.02431843,
0.01139381,
-0.034161285,
-0.016718082,
0.00307841,
0.004998639,
0.002683957,
0.011803369,
0.02631923,
-0.0057976157,
0.005116136,
0.0071907896,
-0.011830225,
0.0019655495,
0.0033385807,
-0.0019470858,
0.030428251,
0.0078152,
0.014878421,
0.016959788,
0.010285985,
0.010124846,
-0.008486609,
0.00062231213,
0.013817595,
0.012045076,
-0.015120129,
-0.0080233365,
-0.019229151,
-0.0016684511,
-0.012662772,
0.02284133,
-0.03469841,
0.007593635,
0.0020125483,
-0.0064320974,
-0.0038035314,
-0.0023532882,
0.008459752,
-0.019618569,
-0.040311392,
-0.015160413,
0.028628876,
-0.0075600646,
-0.024211006,
0.012280069,
0.030992236,
-0.029058577,
0.0049247844,
-0.011487806,
0.006109821,
-0.002477499,
-0.00917816,
0.008976737,
-0.0049247844,
0.036094945,
0.0040720953,
-0.023123322,
0.0037733181,
0.00060384837,
-0.02063911,
-0.015522974,
-0.02653408,
0.010843254,
0.02919286,
-0.054196127,
-0.015898963,
-0.020021414,
0.0031119804,
0.004129165,
-0.01679865,
-0.010057705,
0.013079045,
0.007385498,
-0.0046192934,
-0.009930138,
0.020075126,
0.0526116,
-0.018329464,
-0.0057573314,
-0.030347683,
-0.022465343,
-0.0033604016,
0.051725343,
0.0028971294,
-0.0025664605,
0.016180955,
0.010635117,
-0.011138674,
-0.012098788,
-0.017658055,
0.028172318,
0.0043540867,
0.0017641269,
-0.021323947,
0.011259528,
0.030696815,
0.012582203,
0.01035984,
-0.012743341,
-0.01178994,
0.013871308,
0.035208683,
-0.014569573,
0.001735592,
0.03633665,
0.04407128,
0.017577486,
-0.020679394,
0.008070335,
0.053471006,
0.010990964,
-0.0035181828,
0.003541682,
0.017134355,
-0.009332584,
0.024224434,
-0.015455833,
0.010285985,
0.0040888805,
-0.018974015,
0.01297162,
-0.0070565077,
0.0028299885,
0.016194383,
0.025929812,
0.00811062,
-0.0006294458,
-0.0010943966,
0.033355594,
-0.0032143702,
-0.0024221076,
-0.0056868335,
0.020209407,
0.0051631345,
-0.00855375,
-0.0037934603,
0.011340097,
-0.0009769,
-0.00722436,
-0.032630473,
0.014529289,
-0.0070497934,
-0.02468099,
-0.02477499,
0.0063011725,
-0.004501797,
-0.005132921,
-0.01673151,
-0.0056935474,
-0.0057606883,
-0.012461349,
-0.010292699,
-0.016449519,
0.0046293642,
-0.023378458,
0.04310445,
-0.00097438216,
-0.0014158336,
0.035208683,
0.010782827,
0.007533208,
0.022129638,
-0.03303332,
0.017872905,
-0.00063070474,
-0.011944365,
-0.025271831,
0.013401322,
0.0028115248,
-0.002558068,
-0.005592836,
0.008567178,
-0.012817197,
-0.021928215,
0.026856357,
-0.008842455,
-0.014663571,
-0.013293897,
0.028709445,
0.010420267,
-0.024586994,
-0.0027074565,
0.010091276,
-0.018101184,
-0.008365755,
-0.010520978,
0.005740546,
0.0045521525,
0.003200942,
-0.002027655,
-0.018410033,
-0.019256007,
0.02137766,
-0.0008862598,
0.006771159,
-0.00229454,
0.04428613,
0.019967701,
-0.009292299,
0.00052118115,
0.035396677,
0.005176563,
-0.0028132033,
0.004582366,
0.016959788,
0.002400287,
-0.032711044,
0.025459826,
0.0020931172,
-0.032684185,
-0.042943314,
-0.030401396,
0.004911356,
0.022948757,
-0.003310046,
-0.019229151,
-0.03469841,
-0.010507549,
-0.016852364,
0.011648945,
-0.0066637336,
-0.012031647,
-0.012125645,
0.0011800012,
-0.023942443,
-0.00458908,
0.030508822,
-0.0312608,
-0.0021736864,
-0.021095669,
-0.01747006,
0.000066616354,
0.00995028,
0.007311643,
-0.00550891,
-0.0044816546,
-0.0023851802,
-0.02541954,
-0.0042903027,
0.009090876,
0.006113178,
0.0011069855,
0.025755245,
0.012810482,
0.015267839,
0.00707665,
0.003232834,
0.01569754,
-0.010030849,
-0.015375264,
-0.038216595,
-0.014395007,
0.0020511542,
0.008620891,
0.00050565484,
-0.0048811426,
0.014784425,
0.018383175,
-0.006479096,
-0.020477971,
-0.018544314,
-0.051859625,
-0.009815998,
-0.018584598,
0.0011262884,
0.002118295,
-0.049952824,
-0.006727517,
0.040311392,
0.0058177584,
0.0023767876,
-0.014744139,
0.026493795,
-0.00939301,
0.0030364469,
-0.02241163,
0.022586197,
-0.00037682825,
-0.0008430378,
-0.007835342,
-0.002378466,
0.037733182,
0.010762685,
0.017134355,
0.01270977,
-0.002336503,
-0.018396605,
-0.00482743,
-0.035208683,
0.0038572443,
-0.015267839,
-0.021337375,
-0.011830225,
0.0056096213,
-0.011319954,
-0.0048509296,
0.008177761,
0.0024858916,
-0.027151776,
0.024090152,
-0.040069684,
-0.003130444,
0.011232671,
-0.012548633,
0.034537274,
-0.01679865,
0.04458155,
0.016959788,
-0.0065160235,
-0.012743341,
-0.013965305,
0.016248096,
-0.0015509545,
0.036524646,
0.030428251,
0.013173043,
-0.001523259,
0.009111019,
0.026923498,
-0.02490927,
-0.023982726,
0.017067214,
0.014139872,
-0.020397402,
0.015657255,
-0.004515225,
-0.0059856107,
0.043158166,
-0.0042735175,
-0.008130762,
0.004297017,
-0.016664369,
0.007143791,
0.038136028,
-0.036148656,
0.0025479968,
-0.015952677,
-0.0002444348,
-0.01873231,
-0.03692749,
-0.013173043,
0.0041023083,
0.0011388774,
0.012978334,
-0.02572839,
0.003320117,
-0.0025479968,
-0.007620491,
-0.016758366,
-0.0023130036,
-0.023029326,
0.03904914,
0.0006105625,
-0.021579083,
0.021780506,
-0.0011556626,
-0.002333146,
-0.0047703604,
-0.010165131,
-0.024130436,
-0.015684113,
-0.025030125,
0.027259203,
0.003120373,
-0.011763084,
0.012642629,
-0.014918706,
-0.015093273,
-0.030105976,
-0.009017021,
0.016086958,
-0.034322422,
-0.0028215959,
-0.0041056657,
-0.016825506,
0.032147057,
0.0043406584,
-0.007338499,
0.003974741,
0.014462148,
-0.017201496,
0.015240982,
0.005629764,
0.023647022,
-0.020437688,
0.0021317233,
0.0027846685,
-0.03303332,
0.017564056,
-0.013696742,
-0.010473979,
-0.011830225,
0.01873231,
0.004716648,
-0.009983851,
0.0024221076,
0.01857117,
-0.0028316672,
0.013072331,
-0.0034057216,
-0.030911665,
0.04554838,
-0.027312914,
-0.0028199174,
-0.007593635,
0.010171845,
0.023203893,
-0.022747334,
-0.00031787014,
-0.0031086232,
-0.032388765,
-0.018128041,
-0.0156304,
0.01945743,
-0.037760038,
0.0018900161,
-0.030777384,
-0.0145427175,
-0.024506425,
0.037840605,
-0.005790902,
-0.008204617,
0.011944365,
0.0072646444,
-0.021968499,
-0.0015157056,
-0.005240347,
-0.00004820506,
-0.0018413389,
-0.0023163608,
-0.03389272,
-0.010997678,
-0.009151303,
0.034590986,
0.018638311,
-0.0017976974,
-0.019121725,
-0.03303332,
-0.03340931,
0.01761777,
0.010708972,
0.015052988,
0.0064421687,
0.0028417383,
-0.0067443023,
0.010702258,
-0.00939301,
0.03155622,
-0.03494012,
0.0018178397,
-0.007915911,
-0.004669649,
0.014462148,
0.002371752,
-0.009017021,
0.006552951,
0.0060359663,
-0.004015025,
-0.015348407,
0.013817595,
0.014569573,
0.0050892797,
0.0031573004,
-0.027850041,
0.0035517532,
-0.023499312,
-0.022693621,
-0.021243379,
0.023593308,
-0.018638311,
0.00067015004,
0.0092587285,
-0.028951153,
0.022572767,
0.0027578122,
-0.012434493,
-0.030079119,
-0.039747406,
0.004693148,
-0.03456413,
-0.00663352,
-0.004085523,
-0.0087014595,
0.01916201,
0.0022341132,
0.0014947241,
-0.0020360476,
-0.004078809,
-0.025486682,
-0.0035517532,
-0.004152664,
-0.031851638,
0.0079629095,
0.0035316108,
0.025486682,
0.005112779,
-0.00858732,
-0.03794803,
-0.01614067,
-0.027984323,
0.012400922,
-0.0015358479,
-0.036658928,
-0.0015945962,
0.016274951,
-0.032227628,
0.009977137,
0.0061299633,
0.008714887,
-0.057257753,
0.015146985,
0.010111419,
-0.0012362316,
-0.0011808404,
-0.018329464,
0.00011151683,
-0.014139872,
0.02425129,
0.2091573,
0.016610656,
-0.018987443,
0.007398926,
0.0050322097,
-0.0114072375,
0.035181828,
0.01717464,
0.00038522086,
0.027500909,
0.028064892,
-0.0043205163,
0.0041593784,
0.017698338,
0.013636315,
-0.046031795,
-0.024358716,
-0.01205179,
-0.0071505047,
-0.027984323,
0.0065965927,
-0.0010893609,
0.0059688254,
0.0031438721,
0.006630163,
0.011138674,
-0.009325869,
-0.035477247,
0.031126518,
0.0019269435,
-0.018826306,
-0.0029944838,
0.00086276047,
0.0048408583,
-0.01947086,
0.0051396354,
0.013616173,
-0.015710969,
-0.004609222,
0.013058904,
-0.021068811,
0.006704018,
-0.010957394,
0.02241163,
0.006032609,
0.014099587,
0.01827575,
-0.027245773,
0.0026503867,
-0.001774198,
-0.022169922,
-0.011709372,
0.008714887,
0.02868259,
-0.0035047545,
-0.021256806,
0.016462946,
0.011481092,
-0.019564856,
0.024278147,
0.0011455915,
0.016355522,
-0.01039341,
0.0055794083,
0.0069960807,
0.017000074,
-0.039613124,
0.005545838,
-0.019215723,
-0.013099188,
0.012951478,
-0.028064892,
-0.0138041675,
-0.005629764,
-0.0064992383,
-0.005938612,
0.041090224,
0.018974015,
0.0063716704,
0.016932933,
-0.008372469,
-0.014864993,
0.020289978,
0.0024993196,
-0.019282864,
-0.024184149,
0.018624883,
0.02388873,
-0.0025933168,
0.014583002,
0.0065160235,
-0.0016953076,
-0.013488605,
0.0008056907,
-0.0009584362,
-0.0029290214,
-0.0063213147,
-0.028064892,
0.0067510167,
-0.009822712,
-0.025607536,
0.06934311,
-0.0016306844,
0.007613777,
-0.013455034,
-0.017188068,
-0.0047972165,
-0.018034043,
0.02704435,
-0.0031035878,
-0.01190408,
-0.01990056,
0.015240982,
-0.017376063,
0.0018950517,
0.034805838,
-0.009540721,
-0.0190143,
-0.026332658,
0.0029139146,
0.0077816295,
-0.029246572,
0.004515225,
0.027433768,
-0.009460151,
-0.018141469,
-0.0011455915,
-0.005955397,
0.010279271,
-0.03058939,
0.018128041,
-0.032523047,
0.007459353,
-0.0017062179,
-0.0011850367,
0.015093273,
-0.0015501153,
0.0021636153,
-0.02093453,
0.003615537,
-0.012837338,
-0.020128839,
0.020921102,
0.023418743,
0.023391886,
-0.01054112,
-0.016718082,
-0.005807687,
-0.033919577,
-0.018195182,
-0.009701859,
0.0022324347,
-0.0010222201,
-0.007083364,
0.03456413,
-0.021699935,
-0.033060174,
-0.008043479,
0.0053914133,
0.009191588,
-0.017577486,
-0.013790739,
0.023338174,
0.017872905,
-0.0023448956,
0.02793061,
-0.170699,
0.01584525,
0.001619774,
-0.03206649,
0.017416347,
0.024130436,
0.006311244,
-0.004276875,
0.014515861,
-0.011078247,
0.021834217,
0.014569573,
-0.023257604,
-0.015898963,
0.024157293,
0.0072646444,
-0.012400922,
0.02366045,
0.028387168,
-0.0014057624,
0.014462148,
-0.009983851,
-0.005639835,
-0.005283988,
-0.008694746,
0.024197577,
-0.012743341,
0.019041156,
0.0016827186,
-0.013032047,
-0.020155696,
0.004283589,
0.0323082,
-0.000070602844,
-0.008956595,
-0.0077279164,
-0.021632794,
-0.026574364,
0.0122062145,
0.004149307,
0.0024791774,
0.011420665,
0.018248893,
0.006270959,
0.0070565077,
0.019631997,
0.012837338,
-0.021659652,
-0.006720803,
-0.0027645263,
0.010809683,
-0.023794731,
0.042057056,
0.00556598,
0.0012387495,
0.009829426,
0.00070581865,
0.012743341,
0.016033245,
-0.023351602,
0.002140116,
-0.027662046,
0.005200062,
0.0040888805,
0.009829426,
-0.008674603,
0.002301254,
-0.006109821,
0.0009936852,
0.03757204,
-0.012897765,
-0.021498512,
0.003387258,
-0.029246572,
0.018235466,
0.029488279,
0.013132758,
-0.0018295893,
0.0114676645,
-0.021834217,
-0.0044782977,
-0.008285186,
-0.021941643,
0.007660776,
-0.008876026,
-0.0035718954,
0.0017540557,
0.013025333,
-0.00030297326,
-0.034778982,
0.016530087,
-0.02255934,
-0.008050193,
0.0039008858,
-0.0078084855,
0.0063716704,
-0.020397402,
-0.007204218,
0.012669486,
0.0076742037,
0.0136833135,
-0.004894571,
-0.027232345,
0.011991363,
0.011863795,
-0.00057573314,
-0.016865792,
0.011353524,
0.00991671,
0.007929339,
-0.020182552,
0.011387095,
0.020101983,
-0.009628003,
0.031851638,
0.02351274,
-0.010520978,
0.008211331,
0.017120928,
0.0048408583,
0.043211877,
0.0033889364,
-0.014556145,
-0.007895769,
-0.003043161,
0.024586994,
-0.10973507,
0.02351274,
0.007466067,
-0.0044648694,
0.010272556,
0.013596031,
-0.009829426,
0.0059755393,
-0.008869312,
0.029461423,
-0.008365755,
-0.029300286,
0.007291501,
-0.0102994125,
0.04348044,
-0.031878494,
-0.004391014,
-0.042218193,
0.00053628784,
0.050436236,
-0.003545039,
0.0053007733,
-0.006418669,
-0.03870001,
-0.010749256,
-0.01385788,
-0.030401396,
0.021485085,
0.010420267,
0.0017691625,
-0.008721602,
-0.003056589,
0.004233233,
0.011252813,
0.009614576,
-0.0028837014,
-0.00678123,
-0.009285585,
0.041788492,
-0.0375989,
0.011675801,
0.024519853,
0.015482689,
0.008681317,
0.027017495,
0.005022139,
-0.031019092,
0.017577486,
0.007821914,
-0.012105503,
-0.012400922,
-0.027474053,
-0.010863396,
0.0017456631,
0.0068148007,
-0.027850041,
-0.0024724633,
0.01835632,
-0.020169124,
0.010218844,
-0.011152102,
0.0075466363,
-0.013965305,
0.048771143,
0.04490383,
0.004847572,
-0.01139381,
-0.0013058904,
0.005790902,
-0.00766749,
-0.026252089,
0.014717284,
-0.01747006,
-0.00020761222,
-0.025030125,
0.006549594,
0.01021213,
0.005196705,
0.0027074565,
0.010950679,
-0.010802969,
-0.0010515942,
-0.017161211,
0.007895769,
0.0061501055,
0.017241782,
0.014770996,
-0.026077522,
0.018222038,
-0.03088481,
0.009923424,
0.024922699,
-0.0056062643,
0.0118369395,
0.0156304,
0.0097488575,
-0.0054887678,
0.0018144826,
0.010507549,
0.00692894,
-0.02477499,
-0.024949554,
-0.05817087,
0.016006388,
0.017725196,
-0.005267203,
0.026198376,
-0.005958754,
0.016892647,
0.017282065,
-0.020665966,
0.015831823,
-0.0058211153,
0.012226356,
-0.026131235,
0.003162336,
-0.034376137,
0.005743903,
0.018826306,
0.020383975,
0.034295566,
0.0029944838,
-0.004444727,
0.007922625,
0.0062575312,
0.02114938,
-0.01679865,
0.0070565077,
0.01577811,
0.048529435,
-0.011232671,
0.019927416,
0.0316905,
-0.033919577,
0.029864268,
-0.0049684257,
-0.008896168,
-0.04119765,
-0.0130656175,
0.028655732,
0.007600349,
0.017161211,
-0.007137077,
-0.023593308,
0.016785223,
-0.019027729,
-0.009755571,
0.0065025953,
-0.027312914,
0.019363433,
0.011024535,
-0.015428977,
0.026426654,
-0.0073720696,
0.014395007,
-0.00532763,
-0.02108224,
0.0054048416,
-0.015093273,
0.0038941717,
0.008862598,
-0.01131324,
0.004495083,
-0.0018077685,
0.02336503,
-0.020545112,
0.016825506,
-0.016892647,
-0.015751254,
-0.00011298553,
-0.008406039,
-0.01761777,
0.008459752,
-0.013139472,
0.018987443,
0.0060594655,
0.008157618,
-0.002905522,
-0.025379257,
0.008365755,
-0.025003267,
0.009641432,
0.012897765,
-0.0031220515,
-0.030455109,
0.018544314,
0.01871888,
0.015657255,
-0.01791319,
0.012152501,
-0.015496118,
-0.006556308,
0.012239784,
-0.0037498188,
0.021713365,
-0.015536402,
0.0087014595,
0.043319304,
-0.0136228865,
-0.02668179,
0.017671483,
0.053524718,
0.0074190684,
0.0107895415,
-0.02477499,
-0.028467737,
-0.0283066,
0.0029844127,
-0.0117160855,
-0.019484287,
-0.013193185,
0.021176238,
0.0229219,
0.03824345,
-0.004438013,
0.015536402,
0.0015601865,
-0.026587794,
-0.010809683,
0.014529289,
-0.0035618243,
0.027286058,
-0.017577486,
0.01131324,
-0.0020159052,
-0.021793934,
0.034483563,
-0.0089498805,
0.0052504176,
0.0011481092,
0.015308123,
0.0017423062,
-0.004015025,
0.013790739,
-0.031287655,
0.012159215,
0.010588119,
-0.018880019,
-0.018517457,
0.030804241,
0.017241782,
0.06569065,
-0.015925819,
-0.027742617,
0.0258761,
0.010494121,
-0.0021703292,
0.009346012,
0.012219642,
0.011729513,
-0.016234668,
0.013300611,
-0.014247297,
0.010312841,
-0.034000147,
-0.022451915,
-0.0019907274,
0.0030448395,
0.0107895415,
0.013965305,
-0.00639517,
0.018812878,
-0.0066033066,
0.0005203419,
-0.0139921615,
-0.022290776,
0.01116553,
0.025620963,
-0.00973543,
-0.022519056,
-0.009963708,
0.004612579,
-0.00065462367,
-0.016086958,
-0.00973543,
0.0064388113,
0.001407441,
-0.02078682,
-0.014690427,
0.033919577,
0.0012228035,
-0.0046897912,
0.022492198,
-0.022183351,
0.013569174,
-0.013703456,
-0.052584745,
0.010252414,
-0.005173206,
-0.004172806
] |
beta-Tubulin is encoded in the genomes of higher animals by a small multigene family comprising approximately seven functional genes. These genes produce a family of closely related, but distinct polypeptide isotypes that are distinguished principally by sequences within the approximately 15 carboxy-terminal amino acid residues. By immunizing rabbits with chemically synthesized peptides corresponding to these variable domain sequences, we have now prepared polyclonal antibodies specific for each of six distinct isotypes. Specificity of each antiserum has been demonstrated unambiguously by antibody binding to bacterially produced, cloned proteins representing each isotype and by the inhibition of such binding | [
-0.042197462,
-0.016086103,
-0.025788832,
-0.017174637,
-0.005765195,
0.017295584,
0.00989087,
0.004139114,
-0.020789642,
-0.003428544,
-0.00044011686,
0.005587132,
0.005469544,
0.0056476067,
-0.003796428,
0.0064236904,
0.022361968,
0.019983321,
0.0034537415,
0.01601891,
-0.018021274,
0.021192802,
0.0028590797,
-0.031150866,
-0.021851297,
0.011590864,
0.00826479,
-0.05042194,
-0.03367734,
-0.017685307,
0.0001653588,
-0.012229201,
-0.034349274,
-0.012209043,
-0.0032404023,
-0.026071046,
0.007492066,
0.022294775,
0.032010943,
0.02255011,
0.022187265,
0.024821248,
0.0061784345,
-0.0033798288,
0.009380201,
0.010280592,
0.0013304296,
-0.0057719145,
-0.032091573,
0.0001560147,
0.0052713235,
0.018330364,
-0.011254896,
-0.0036284444,
-0.012477817,
-0.010287312,
0.0030740986,
-0.00173359,
0.0067025432,
-0.016677406,
0.0048345663,
-0.002336651,
-0.024767492,
-0.012511414,
-0.008694828,
-0.0009029115,
0.01724183,
0.0066991835,
0.010992843,
-0.01357307,
0.021878175,
0.0048816013,
-0.0053149993,
-0.014110617,
0.044938955,
-0.025130337,
-0.026904242,
-0.0013783049,
0.002499595,
0.02521097,
0.012793626,
-0.0032168848,
0.004965593,
0.011167546,
0.010347785,
-0.0006513562,
-0.0011691654,
0.01581733,
0.0037493925,
0.0060339686,
0.018881349,
0.021152487,
0.012222482,
0.020063953,
-0.013317735,
0.0078078746,
-0.0052310075,
0.04875554,
-0.023840223,
-0.011678215,
-0.0144331455,
0.016744599,
0.0058928626,
-0.021582525,
-0.012316553,
0.0044851606,
0.014419707,
-0.009447394,
-0.005808871,
-0.0065647964,
-0.028436253,
0.052410863,
0.005865985,
-0.04268126,
0.013156471,
0.008022893,
0.011147387,
-0.0018612576,
-0.0070821857,
0.0017369498,
0.013841843,
0.040638577,
0.009863993,
-0.011503512,
0.041659918,
0.01724183,
-0.006245628,
-0.0064640064,
0.0044851606,
0.009743045,
0.024539035,
0.010267153,
0.006914202,
0.007996016,
-0.013828404,
-0.0036922782,
-0.01622049,
-0.010797981,
-0.004041684,
-0.031043358,
0.012269517,
0.024700299,
-0.010905491,
0.0069813957,
0.0024659983,
0.015441046,
0.021179365,
0.017994396,
0.01397623,
0.0075861365,
-0.0036788394,
-0.01417781,
0.01224264,
0.006853728,
-0.000053334774,
-0.0050865416,
-0.009548184,
0.022872638,
-0.036445707,
0.0007689446,
-0.01112051,
0.021313751,
0.02490188,
-0.008123684,
0.04531524,
0.016690845,
0.018800717,
0.0028305226,
-0.009171901,
-0.01234343,
-0.012497975,
-0.006047407,
-0.02530504,
0.01948609,
-0.02214695,
0.0007084706,
0.0044717216,
0.005540097,
-0.029000677,
-0.010488892,
-0.00643041,
-0.0020275612,
0.010139486,
-0.0003479359,
-0.011611022,
0.0066151917,
0.007613014,
-0.017443411,
0.0012271197,
-0.016569896,
-0.0058727046,
-0.006813412,
0.018652892,
-0.013801527,
-0.6467769,
-0.038891546,
0.029726366,
-0.025882903,
0.014124055,
0.027764319,
0.0032387224,
-0.01367386,
-0.03338169,
0.028920045,
-0.021044977,
0.0104687335,
0.0123904655,
-0.034618046,
-0.025184091,
-0.040154785,
-0.007989297,
-0.014984132,
0.024418086,
0.005083182,
-0.010152925,
-0.010341067,
-0.022388846,
0.018505067,
0.013512596,
-0.0047304165,
0.024955634,
-0.026353257,
-0.003285758,
0.025372233,
-0.03553188,
0.043944493,
0.0023114535,
-0.011711812,
0.048191115,
0.007720523,
-0.003408386,
0.0105896825,
0.023033902,
0.039348464,
0.0051369364,
-0.01662365,
0.009360042,
-0.009467552,
-0.006386734,
0.04644409,
0.009548184,
0.01132881,
0.003070739,
-0.017094005,
-0.0017655069,
-0.0023836864,
-0.022805445,
-0.0052142087,
-0.01153039,
0.010724069,
0.015992032,
-0.024310578,
0.00055560557,
0.008311825,
-0.011396003,
-0.007693646,
0.0033630303,
-0.004421327,
-0.014728797,
-0.005560255,
-0.027710564,
-0.013922475,
0.00090459135,
0.006692464,
0.015333537,
0.014822867,
-0.0014614568,
-0.020373043,
0.015884522,
0.046148438,
-0.0038233052,
-0.012088095,
0.0021401101,
0.0014421387,
0.0058928626,
0.0047673727,
-0.018034711,
0.0010347785,
0.004965593,
0.006847009,
-0.010213399,
0.032387227,
0.014715358,
0.005039506,
0.01193355,
0.0035847686,
-0.0024878362,
-0.03152715,
-0.031097112,
0.013001925,
0.019230755,
0.023275798,
-0.00013207705,
-0.035397492,
-0.015226028,
-0.013015364,
0.007088905,
-0.002672618,
0.009071111,
-0.016811792,
-0.008943443,
0.006988115,
0.035746895,
-0.0062355488,
-0.0023618485,
-0.00081891974,
-0.009158462,
-0.01305568,
0.014648165,
-0.02121968,
0.0055535357,
0.010549366,
0.010663595,
-0.030237036,
0.006151557,
0.0053217183,
-0.0022912954,
0.0071695372,
0.022509793,
0.015978593,
-0.012269517,
-0.012605485,
0.0008478969,
-0.009124866,
-0.009937906,
0.006786535,
0.022066317,
-0.0023601686,
0.013001925,
0.014943815,
0.039025936,
0.017080566,
0.0021636279,
-0.032736633,
-0.014245003,
-0.012847381,
0.0014866543,
-0.016045786,
-0.0018444592,
-0.025157215,
-0.03184968,
0.020225218,
0.015790453,
0.0067462185,
0.022120072,
0.018652892,
0.0077406815,
-0.0035545316,
0.031715292,
0.0038300245,
-0.03507496,
-0.03980538,
0.01755092,
-0.0016974736,
0.013552912,
-0.008036332,
-0.025291601,
0.010744227,
-0.01530666,
-0.01724183,
0.010791263,
0.017389655,
-0.025735078,
-0.033301055,
0.014003107,
-0.03131213,
-0.009857274,
0.013653702,
-0.008506686,
0.030129528,
-0.0030337826,
0.003080818,
-0.011463196,
-0.009265971,
-0.0065815947,
-0.011664777,
-0.021891614,
-0.015293221,
0.040154785,
0.012639081,
0.031500272,
-0.0021989045,
0.007337521,
0.024404649,
0.006507682,
0.009420517,
-0.0027566098,
0.0045657926,
0.0016873946,
-0.019768303,
0.042573746,
0.013190067,
0.018195977,
0.009339885,
0.006060846,
-0.021595962,
-0.01214185,
-0.016381754,
0.016462386,
-0.032602243,
-0.005664405,
-0.031688415,
0.0053351573,
-0.004522117,
0.005419149,
0.0023584887,
-0.013586508,
0.0018511786,
0.007532382,
-0.0015294901,
-0.019768303,
0.004098798,
0.0031765685,
-0.009097989,
-0.00581559,
0.009870713,
0.013633544,
0.0009642255,
-0.027508983,
0.0060138106,
-0.00059634156,
0.022321653,
-0.011375845,
-0.011846199,
-0.021179365,
0.019983321,
-0.0018595777,
0.013230383,
0.003122814,
0.0115236705,
-0.0032000863,
-0.003887139,
0.05692626,
0.0037527522,
-0.005926459,
0.002724693,
0.0038602615,
-0.0046296264,
0.011725251,
0.013566351,
0.011543829,
0.014271881,
0.012256078,
0.008446212,
-0.005869345,
-0.0027683687,
-0.016516142,
0.009528026,
0.00032609803,
-0.0096691325,
0.013640263,
0.015763575,
0.03641883,
0.015266344,
0.021125609,
0.023517694,
0.0024340814,
0.0029867473,
-0.012686117,
0.006954518,
0.0013497476,
-0.0017537482,
0.0036082864,
0.0008457971,
-0.020829959,
0.012928013,
0.031070234,
-0.01060984,
0.019580161,
-0.008271509,
-0.011174264,
0.01519915,
0.00826479,
0.021367505,
-0.031715292,
-0.03604255,
0.012020902,
0.020722449,
-0.013626824,
-0.013492437,
-0.020023637,
-0.0048412853,
-0.004253343,
0.0075458204,
-0.0028490007,
0.007337521,
-0.00479761,
0.028167479,
0.008284948,
-0.015951717,
0.02427026,
-0.013788088,
-0.016583335,
-0.0028725185,
0.0016479185,
-0.014943815,
-0.002481117,
-0.007028431,
0.028597517,
0.0055568954,
-0.029403837,
0.00030174042,
-0.017228391,
-0.020668695,
0.013042241,
-0.0058323885,
-0.0023148132,
-0.0039946483,
-0.00064337696,
0.0012036021,
0.013653702,
0.0066454285,
0.027173016,
-0.0051873317,
-0.022738252,
-0.029538225,
-0.011637899,
0.015575433,
0.0037057167,
0.015212589,
0.001274995,
0.0177525,
0.0125248525,
0.01948609,
-0.030640196,
-0.013237103,
0.02724021,
-0.02225446,
-0.023329554,
-0.0011263296,
0.02213351,
-0.0125382915,
-0.0062624263,
0.014634726,
-0.002610464,
-0.024068682,
0.020843398,
0.018303486,
0.018908227,
0.016153296,
0.010159644,
0.032817263,
0.021421261,
-0.019580161,
0.023692397,
0.03956348,
0.0075458204,
-0.0369295,
0.0025449505,
-0.0011490074,
-0.014540655,
0.007935543,
-0.0011590864,
-0.030048896,
-0.0023181727,
0.04569152,
0.013841843,
0.014742235,
0.0028170838,
0.025358794,
0.009447394,
0.019848935,
-0.0038401035,
-0.016233929,
0.010388101,
-0.007539101,
-0.0023198526,
-0.016099542,
0.007109063,
-0.010152925,
-0.004176071,
-0.028597517,
0.0052142087,
0.00073954754,
-0.0028086847,
-0.004643065,
-0.016811792,
-0.023826785,
0.00907783,
-0.022563549,
0.0041895094,
-0.0128541,
-0.010871895,
-0.013680579,
-0.010320908,
0.0035545316,
-0.02581571,
-0.012195605,
0.01357307,
-0.04426702,
-0.019418897,
-0.03316667,
0.0030892172,
0.016193613,
-0.004323896,
-0.021972246,
0.009863993,
0.026662346,
-0.025291601,
-0.017900325,
-0.0086410735,
-0.048137363,
-0.010488892,
0.01846475,
0.018115344,
-0.017497165,
-0.00377627,
-0.01275331,
0.022052879,
-0.023007024,
0.012202324,
0.009050953,
0.00927941,
0.0037930682,
0.006752938,
0.037762698,
-0.00142786,
-0.036257565,
-0.0011868037,
-0.018626014,
0.019741425,
-0.031580906,
0.0048816013,
-0.0014496979,
-0.014742235,
-0.010502331,
-0.007908665,
-0.0033731093,
0.012289676,
-0.014930377,
0.008869531,
0.006847009,
0.0041357544,
0.015037886,
-0.011463196,
0.008331983,
-0.0020745967,
-0.014675042,
-0.0039308146,
-0.00086259545,
0.012175446,
0.012887697,
-0.029054433,
0.020144586,
0.012464378,
-0.0045725117,
0.011053316,
-0.012000743,
0.0020729168,
0.023074219,
-0.0048211273,
-0.019163562,
-0.023437062,
-0.014124055,
-0.021501893,
0.00049345166,
0.020977784,
-0.0010977724,
-0.00326392,
0.008016175,
0.004733776,
0.0026289423,
-0.015777014,
-0.030371424,
-0.0143390745,
0.027482105,
0.0068806056,
0.0058391076,
0.012867539,
-0.00067193416,
-0.012229201,
0.0038031472,
-0.0159114,
-0.033489197,
0.007881788,
-0.007458469,
0.03612318,
0.04295003,
0.030075772,
0.0039711306,
0.007028431,
0.041068614,
-0.0023097736,
0.025170652,
-0.013841843,
0.025412548,
-0.026568277,
0.0011103712,
-0.0006311981,
-0.009111427,
0.015346976,
-0.019701108,
0.011073475,
0.020373043,
-0.034510538,
-0.010502331,
0.0054023503,
-0.028221235,
-0.039375342,
0.008271509,
-0.015978593,
0.004202948,
-0.03744017,
-0.014056862,
0.022697935,
0.009743045,
0.006091083,
-0.003070739,
0.031903435,
-0.0181691,
0.021461576,
0.0038501825,
0.015682943,
-0.0070620277,
-0.011167546,
-0.0016655568,
0.00036746397,
0.012901136,
0.0035142156,
0.0045321956,
0.023127973,
0.0058122305,
0.0018091827,
-0.010677033,
-0.011994025,
-0.016919302,
-0.011375845,
-0.012383746,
-0.018585699,
-0.027791196,
-0.021488454,
-0.039025936,
0.00053586747,
0.019445773,
-0.024713738,
0.019459212,
0.0028422815,
-0.023181727,
0.022684496,
-0.019566722,
0.041552406,
-0.008311825,
0.019217316,
0.028839413,
0.0035679704,
-0.014634726,
-0.038058348,
-0.006907483,
0.011550548,
0.013398367,
0.02397461,
0.01886791,
-0.025251284,
0.0065043224,
0.01305568,
-0.023208605,
-0.03346232,
0.018115344,
-0.01601891,
0.02275169,
0.0028825975,
-0.004619547,
0.0012321592,
0.024444964,
-0.021905053,
0.012981768,
-0.017268708,
-0.012235921,
-0.031580906,
0.0025247924,
-0.010314189,
0.034618046,
-0.007277047,
-0.011409442,
-0.002499595,
-0.0010986123,
0.0012775147,
-0.010999562,
0.0058189495,
0.03375797,
0.013566351,
-0.0018478188,
0.023248922,
0.0007420673,
-0.0024357613,
-0.021448137,
0.012712994,
0.044938955,
-0.01948609,
0.006396813,
-0.0023064138,
0.0066991835,
0.016596774,
-0.004092079,
-0.0056543257,
-0.020386482,
-0.021058416,
0.014554094,
0.013082557,
0.010307469,
-0.003746033,
-0.005543457,
-0.01386872,
0.0059197396,
-0.040181663,
-0.03316667,
0.017403094,
-0.0550986,
0.005970135,
-0.0012867539,
0.021676596,
0.0053351573,
0.008909847,
0.011389283,
-0.003273999,
0.01336477,
-0.0369295,
-0.009917748,
0.008701547,
0.0039946483,
-0.032467857,
-0.011174264,
-0.01245094,
-0.014688481,
0.004253343,
-0.026850488,
-0.018639453,
0.015561995,
-0.0143928295,
0.023907417,
0.0106299985,
-0.037520804,
0.015615749,
-0.010280592,
0.03346232,
-0.0053754733,
0.0045456346,
0.010556085,
-0.010193241,
0.018988859,
-0.012296394,
-0.012020902,
-0.014863183,
0.009427236,
-0.033784848,
-0.005325078,
-0.014769113,
-0.032494735,
0.0006610152,
-0.006316181,
-0.0054527456,
-0.008782179,
0.004122316,
-0.027818073,
-0.014446584,
0.004102158,
-0.017161198,
-0.004948795,
-0.008164,
0.010448576,
0.00530828,
-0.0021753868,
-0.022617303,
-0.019029174,
-0.0038401035,
-0.027253648,
-0.024955634,
0.011550548,
-0.017779378,
0.048674908,
-0.005929819,
-0.0073039243,
0.012182166,
-0.0012523172,
-0.019741425,
-0.00062363886,
0.020278972,
-0.00079204235,
-0.0025348715,
0.012833942,
-0.013855282,
0.0005803831,
0.0029229135,
0.019607037,
-0.0013489078,
-0.006201952,
0.02163628,
0.017819693,
-0.006967957,
0.023423623,
-0.031070234,
-0.006806693,
0.04356821,
-0.0143928295,
-0.025856026,
0.027656808,
-0.03010265,
0.0030438616,
-0.0125248525,
0.010838298,
-0.03397299,
0.015588872,
0.025130337,
-0.022697935,
-0.014500339,
-0.008137123,
0.005274683,
-0.0133378925,
0.004663223,
-0.00011412382,
0.00602053,
0.01764499,
-0.035961915,
-0.02662203,
-0.0053015603,
-0.000022179076,
0.035263103,
0.042412482,
-0.007828033,
0.008896408,
0.01019996,
0.00080758083,
-0.015602311,
0.0040450436,
-0.0068806056,
-0.0039476133,
-0.011570706,
0.0011397683,
0.0056173694,
-0.012081376,
-0.0028590797,
-0.017631551,
0.008345422,
0.015682943,
-0.0037695505,
-0.022939831,
0.0047169775,
0.019754864,
-0.0040685614,
-0.010824859,
-0.0064740856,
0.0057181595,
-0.023074219,
-0.009091269,
-0.012424062,
0.006410252,
-0.017403094,
-0.0039543323,
-0.026648909,
-0.0067697363,
-0.024942195,
-0.0100051,
-0.027764319,
-0.006793254,
0.17567046,
-0.0242837,
0.0049723126,
0.012726433,
0.00063329795,
0.00030552005,
0.0066051125,
-0.02682361,
-0.012094814,
-0.0017218313,
0.02448528,
0.019042613,
0.007639891,
0.0017025131,
0.006776456,
-0.015750136,
-0.02203944,
0.005704721,
-0.013169909,
0.0048110485,
0.0036620412,
-0.0066689462,
0.0077877166,
-0.0037225152,
0.026245747,
0.019956443,
-0.021125609,
-0.0032672798,
0.00003695638,
-0.006551358,
-0.025976975,
-0.017080566,
-0.008345422,
0.0043339753,
0.011295213,
0.0068503683,
-0.008815776,
0.0037829892,
0.00989087,
0.0181691,
0.0049756723,
0.02335643,
-0.0025785472,
-0.018652892,
-0.019620476,
-0.006087723,
0.0065043224,
-0.007881788,
-0.010246996,
0.020332728,
-0.029430715,
0.020171463,
0.020225218,
0.014070301,
-0.0056980015,
-0.014970693,
0.03021016,
0.015844207,
-0.0050529446,
0.019983321,
-0.007975859,
0.008788899,
-0.029860754,
0.03356983,
-0.0008285788,
0.03660697,
-0.0097968,
0.0063229003,
0.038192738,
-0.031795923,
-0.00927941,
-0.009776642,
-0.008090087,
0.021784104,
0.0039240955,
-0.017255269,
0.033327933,
0.035155594,
0.010515769,
0.015965154,
0.012128411,
-0.0068201316,
-0.030667074,
-0.003020344,
-0.015629187,
-0.0134050865,
0.042278096,
0.00070469093,
-0.011295213,
0.013962791,
0.00017879748,
-0.02183786,
-0.0019418896,
0.013909036,
0.00234673,
0.009319726,
-0.013640263,
-0.0022492995,
-0.010374663,
-0.039859135,
-0.0054930616,
0.07369774,
0.008688108,
0.024740616,
-0.02173035,
0.0143659515,
-0.00835886,
-0.0026910962,
0.0034352632,
-0.023033902,
0.010556085,
-0.043138172,
0.006988115,
-0.019405458,
0.01855882,
0.018881349,
0.024216507,
-0.01886791,
0.020735888,
-0.00632962,
0.0014816148,
-0.04531524,
0.01346556,
0.016583335,
0.002471038,
0.0014211407,
-0.025385672,
0.007848191,
0.0018612576,
-0.038354002,
-0.0105628045,
-0.010179802,
-0.00036578416,
0.010730788,
-0.003153051,
-0.004700179,
-0.013035523,
-0.012739872,
-0.03254849,
0.03386548,
-0.0067831753,
0.0011792444,
0.033005405,
-0.009030795,
0.0009877431,
-0.00142786,
0.013546192,
0.027132701,
-0.021018099,
-0.01040826,
-0.0019351704,
-0.026433889,
-0.020843398,
-0.009232375,
0.008943443,
-0.024539035,
-0.0024760773,
-0.049776882,
0.0013959432,
0.0048009693,
-0.022966709,
-0.017819693,
0.030344546,
-0.0052578845,
-0.0062624263,
-0.003920736,
-0.16986495,
0.0021602684,
0.03193031,
-0.020104269,
0.010105889,
0.0053183585,
0.01121458,
-0.01765843,
0.01305568,
0.0036654007,
0.020682134,
-0.005019348,
-0.029941386,
-0.02805997,
0.0012775147,
0.002336651,
-0.006914202,
0.032199085,
0.018021274,
0.0024105636,
0.028624395,
-0.02377303,
0.013458841,
-0.004673302,
0.009185339,
0.031177744,
0.00040966985,
-0.009131585,
0.017389655,
-0.018343803,
-0.012793626,
0.0039442535,
0.03211845,
-0.014150933,
0.01804815,
0.011926831,
-0.00092306954,
-0.008217755,
-0.02174379,
0.004538915,
0.018599138,
0.021770665,
0.01194027,
-0.0085201245,
0.009057672,
0.036257565,
0.017228391,
0.0067092623,
0.026259186,
0.0000042225547,
0.004599389,
-0.0114430385,
0.021488454,
0.024928756,
0.030532688,
-0.006894044,
0.009124866,
0.030183282,
-0.025587251,
0.0073845563,
-0.0018528583,
-0.023746153,
0.03437615,
-0.034107376,
-0.012807065,
-0.04397137,
-0.01978174,
-0.0046665827,
-0.008499967,
-0.0021300311,
-0.006907483,
0.0048144083,
0.0013749453,
-0.038085226,
0.0030270633,
0.016328,
-0.011563987,
-0.009857274,
-0.0011515272,
-0.006060846,
-0.019297948,
0.019244194,
-0.037789576,
-0.025291601,
0.0011389283,
0.012612204,
-0.009265971,
0.015642626,
-0.005661045,
-0.0019452494,
0.010186521,
-0.0144869005,
-0.018760402,
-0.014970693,
0.005624089,
0.0143256355,
-0.019203877,
-0.022617303,
-0.001652118,
-0.007539101,
0.032387227,
-0.016341439,
-0.007223292,
0.033784848,
0.03690262,
0.02468686,
0.008896408,
0.009353323,
0.03652634,
0.027925583,
0.015830768,
0.0009339884,
-0.008950163,
0.014836306,
-0.002089715,
0.02733428,
-0.016489264,
-0.0014312197,
0.016287684,
-0.030452056,
0.07514911,
0.011476635,
0.00560729,
0.017094005,
0.0009575061,
-0.025116898,
-0.13933226,
-0.016233929,
-0.0029212337,
0.020762766,
-0.019701108,
0.012887697,
-0.0024525595,
0.048674908,
-0.017188076,
0.03131213,
0.011315371,
-0.006272505,
-0.019203877,
-0.016233929,
-0.007680207,
0.0318228,
-0.006376655,
0.010367944,
-0.020467114,
0.015978593,
-0.002439121,
0.0033815086,
0.022026,
0.007828033,
0.027078945,
-0.029135065,
-0.028086847,
0.015521679,
0.0041491934,
0.013653702,
-0.006873886,
-0.009729606,
0.007901945,
-0.015629187,
-0.0006752938,
-0.010105889,
-0.01326398,
-0.02253667,
0.045557134,
0.017483726,
-0.0068201316,
0.010065573,
-0.013311015,
-0.00008236443,
0.0224426,
-0.025412548,
-0.0019469291,
0.0036351637,
-0.006081004,
-0.02041336,
-0.019177001,
-0.008835934,
-0.045745276,
-0.009467552,
0.013694018,
-0.0051705334,
-0.004021526,
0.021058416,
0.0071426597,
0.019929567,
0.01764499,
0.0018226213,
0.00142786,
-0.00047245368,
0.009165182,
-0.00013554172,
-0.02092403,
-0.020574624,
0.029269451,
-0.06047407,
0.0009474271,
0.0043406948,
0.00065849547,
-0.00888297,
-0.026474206,
-0.012088095,
-0.02030585,
-0.007901945,
0.018599138,
-0.016180174,
-0.013828404,
-0.0114699155,
0.013949352,
-0.016139857,
0.013324454,
0.021139048,
0.014245003,
0.00007233791,
0.0059802136,
-0.012188885,
-0.0053351573,
0.027508983,
-0.0029128345,
-0.013895598,
-0.0104821725,
0.02601729,
-0.009360042,
-0.017739061,
0.014554094,
0.022886077,
-0.029968264,
-0.026447328,
-0.05163142,
0.025278162,
0.008997198,
-0.0066454285,
0.024659984,
0.004243264,
0.016489264,
0.0055938517,
-0.0052175685,
0.028946923,
-0.010152925,
0.0028641194,
-0.03233347,
-0.0143659515,
-0.01397623,
-0.018236293,
0.032682877,
-0.006185154,
0.016462386,
0.019822057,
-0.015844207,
0.0133378925,
0.021098731,
0.027159577,
-0.03448366,
-0.023907417,
-0.017268708,
0.02623231,
-0.016650528,
0.0047304165,
0.013841843,
-0.028731903,
-0.004713618,
0.013109435,
-0.00101966,
0.003324394,
0.00968929,
0.020735888,
0.03459117,
0.027764319,
-0.024875002,
-0.035773773,
0.004774092,
-0.013532754,
-0.008748583,
0.003856902,
-0.039859135,
0.007008273,
0.005624089,
-0.008499967,
0.027374597,
0.018142221,
0.012047779,
-0.038488388,
-0.030774584,
-0.007915384,
-0.010455295,
0.004878242,
-0.0014564173,
-0.004159272,
0.0019351704,
0.017403094,
-0.0072703273,
-0.0004264682,
-0.013989668,
0.0057349578,
-0.016408632,
-0.0043339753,
0.0036989974,
-0.035048086,
-0.02357145,
0.011899954,
0.012477817,
0.013949352,
-0.0070015537,
0.002704535,
-0.008607476,
0.0029413917,
-0.011053316,
0.022294775,
0.0014967333,
0.010824859,
-0.022590427,
0.018988859,
0.021555647,
-0.0068806056,
0.006007091,
0.01020668,
0.005970135,
-0.0085873185,
-0.008486528,
0.01510508,
-0.0037225152,
0.017819693,
-0.0144869005,
0.018384118,
-0.0032807183,
0.025963536,
0.0065647964,
0.013539473,
-0.015064764,
-0.010804701,
0.007203134,
-0.0066051125,
0.00007323032,
0.0095213065,
-0.021179365,
-0.037574556,
-0.02081652,
-0.017886886,
0.008990479,
0.0035814089,
-0.007922104,
0.008499967,
-0.00643041,
-0.0023618485,
-0.0029632295,
0.009138305,
-0.0125248525,
0.017053688,
-0.0008550362,
0.031473394,
-0.0123904655,
0.0059600556,
0.020063953,
0.0036452427,
0.028409375,
-0.032682877,
0.014957254,
-0.008990479,
-0.004733776,
-0.025184091,
-0.013882159,
0.00046573434,
0.0030690592,
-0.0070956247,
0.008862811,
0.0206015,
-0.012249359,
0.083481096,
0.0016403592,
0.0036687604,
0.016287684,
-0.009185339,
0.0054930616,
0.0275493,
0.019943004,
0.00010593462,
-0.022509793,
-0.006128039,
0.006887325,
0.021690033,
-0.009662413,
-0.014836306,
0.013190067,
-0.020211779,
0.004508678,
-0.0036922782,
-0.019445773,
0.008311825,
-0.026272625,
0.014849745,
0.01857226,
-0.012847381,
0.015790453,
0.023934294,
0.013734334,
0.010079012,
-0.04448204,
0.002743171,
-0.007337521,
-0.032602243,
-0.015051325,
-0.00083571806,
-0.014661603,
-0.004985751,
0.007277047,
0.015252905,
-0.005425868,
-0.003040502,
-0.014957254,
-0.011799163,
-0.0114295995,
0.015091641,
-0.009360042,
-0.027683686,
-0.014406268,
-0.0031664895
] |
INTRODUCTION Topiramate (TOP) blocks glutamate receptors and facilitates GABA (γ-aminobutyric acid) neurotransmission, effects that may facilitate smoking cessation. We compared the effects of behavioral counseling combined with (a) TOP, (b) TOP/nicotine patch (TOP/NIC), or (c) placebo (PLC) for smoking cessation. METHODS We conducted a 10-week randomized trial in which subjects and research personnel were blinded to TOP versus PLC but not to the TOP/NIC patch condition. In groups receiving TOP, the medication dosage was titrated gradually up to 200 mg/day. The smoking quit | [
-0.014494807,
0.0071182284,
0.018111711,
-0.05009275,
-0.012162857,
0.007138625,
-0.013876126,
0.00047038437,
-0.03456454,
-0.005833276,
0.007818494,
0.017472634,
-0.013746952,
0.018642008,
-0.008165227,
0.0011566272,
0.03508124,
-0.0023540466,
-0.025359115,
0.022802807,
-0.0052281925,
-0.0030135193,
-0.0039466396,
-0.021470264,
0.010830313,
0.007485358,
0.009327803,
-0.036522564,
-0.021715017,
0.016738376,
-0.008736317,
0.015419429,
-0.0024543272,
-0.018750787,
-0.01323705,
-0.0076961173,
-0.018968346,
0.0033619523,
0.004272977,
-0.0036101046,
0.012292032,
-0.002428832,
0.023605052,
0.034346983,
-0.016683986,
0.0108575085,
0.0006050834,
-0.015106689,
-0.024162544,
0.016058506,
0.0017591611,
0.013427413,
0.0021942772,
-0.020287292,
0.01380814,
-0.00441235,
0.02030089,
0.008002059,
0.024284922,
-0.041499205,
-0.009769718,
-0.0150523,
-0.017975736,
0.014957119,
0.017934944,
0.02253086,
-0.015419429,
0.007804896,
0.016425636,
0.001328294,
0.012060876,
0.03611464,
-0.004334165,
-0.01053797,
0.027793046,
-0.009212225,
-0.023673039,
-0.010177639,
-0.0056735068,
0.019185904,
0.013638172,
-0.008287603,
0.005367566,
0.009844503,
0.013073881,
0.011958896,
0.0012798534,
-0.0010597458,
-0.017472634,
-0.0018713395,
-0.015772961,
0.036141835,
0.015664183,
0.023686636,
-0.010497178,
0.036821704,
-0.019865772,
0.063690126,
-0.00877031,
-0.01884597,
0.01573217,
-0.00690407,
-0.017105505,
-0.008260408,
0.012869921,
-0.009015063,
-0.019117916,
0.00072108605,
0.03325919,
0.0035455169,
-0.005942055,
0.02444809,
-0.038263027,
-0.008906284,
-0.0181661,
0.01531065,
0.016126493,
-0.0096269455,
-0.0010418993,
-0.020028941,
0.0073221894,
0.00008078756,
0.023414688,
0.006509746,
0.020831186,
0.018084515,
-0.015473818,
-0.021606237,
-0.011856915,
0.0021194916,
0.0009492671,
0.028146578,
0.02030089,
0.0130874785,
-0.015215469,
0.008307999,
0.008110837,
-0.016425636,
-0.031790674,
-0.015800156,
0.01204048,
0.015664183,
-0.0022452674,
-0.018302074,
-0.025155153,
0.023985779,
0.030077405,
0.03192665,
0.010626352,
0.017459037,
-0.014304444,
-0.029560706,
-0.004973242,
0.013712958,
0.009518166,
0.0016843755,
-0.013950912,
0.024434492,
-0.0141820675,
-0.010748729,
0.023550663,
-0.030186184,
-0.0036271012,
0.011020677,
0.016221674,
0.038072664,
0.024420895,
-0.023333104,
0.003902448,
-0.0018050523,
-0.007974864,
0.034972463,
-0.030458132,
0.037664745,
-0.020736005,
0.013481802,
-0.008104038,
0.010170841,
0.02221812,
-0.002226571,
-0.027534695,
0.010435989,
0.024529673,
0.012761141,
-0.023265118,
-0.0075125527,
-0.0010920396,
-0.0012637065,
-0.0025665055,
-0.020110525,
-0.0090218615,
0.017513426,
-0.018601216,
-0.008858693,
-0.6300482,
-0.012781537,
0.015650585,
-0.027983408,
0.025671855,
-0.004374957,
0.033150412,
0.016874349,
-0.005234991,
0.022816405,
0.020096928,
0.0264741,
0.027425917,
-0.019403461,
-0.023142742,
-0.009647341,
-0.0071998127,
0.021619834,
-0.0024169344,
-0.0020532045,
-0.0040044286,
0.008090441,
-0.0031358958,
0.040057883,
0.030811664,
0.010544769,
0.0007967215,
-0.020015344,
-0.0061834087,
0.022979572,
-0.005775487,
0.0017931545,
0.020314487,
0.011646156,
0.044816967,
-0.028826445,
-0.038507782,
0.006519944,
0.018981943,
0.039513987,
-0.019784188,
-0.0083012,
0.023890598,
0.0024560269,
-0.009327803,
0.015840948,
-0.0033755496,
0.014671573,
0.0023540466,
-0.013923718,
-0.005663309,
-0.002112693,
-0.010198035,
0.017798971,
0.019553034,
0.020586433,
0.025549477,
-0.006057633,
0.010245626,
-0.007988461,
-0.0006191057,
0.001707321,
-0.008274006,
-0.01645283,
-0.034727708,
0.014440418,
0.0013597381,
0.010864307,
0.025263933,
-0.030349353,
0.020844784,
0.014209262,
-0.0026446905,
-0.009151037,
0.03741999,
0.020926367,
0.022245314,
0.0031239982,
0.0025461095,
0.007104631,
0.006975456,
-0.0016537814,
-0.0347821,
-0.014834742,
0.014263652,
-0.0017141198,
-0.026338127,
-0.0003837011,
0.0141820675,
-0.0022996569,
0.013726556,
-0.0054049585,
-0.019838577,
-0.039378013,
-0.028826445,
0.013073881,
-0.0015246063,
-0.0024322313,
0.0152562605,
-0.0101164505,
-0.0074717603,
0.0073833773,
-0.005313176,
-0.004935849,
0.042478215,
-0.01588174,
-0.025767036,
0.0032055825,
0.035625137,
-0.0033024638,
0.016575206,
-0.0125979725,
-0.002158584,
-0.0116801495,
0.03445576,
-0.02210934,
0.009395789,
-0.019267488,
-0.013556588,
-0.05278503,
0.010245626,
-0.010830313,
0.025671855,
0.0013274442,
-0.001665679,
0.014617184,
0.007770903,
0.014141276,
-0.018723592,
-0.0023285514,
-0.004548324,
0.01982498,
0.015133884,
0.0051670047,
0.009089849,
-0.0032939655,
0.009871698,
-0.0047522844,
0.0048202714,
-0.04495294,
-0.005200998,
0.011326618,
0.0058944644,
0.0150523,
0.000096562646,
-0.02719476,
0.004069016,
0.0013784345,
-0.03508124,
-0.001172774,
0.017567815,
-0.007634929,
0.0062887883,
0.012122065,
0.034482956,
-0.027752252,
-0.005734695,
-0.04552403,
-0.02133429,
0.0029965227,
0.022136535,
0.01448121,
-0.019131513,
-0.016833557,
-0.015174677,
-0.0446266,
0.013590582,
0.025930203,
0.00633298,
-0.01416847,
-0.0007843989,
-0.04976641,
0.0075533446,
0.010966287,
-0.010028068,
0.012944706,
0.030866053,
-0.009402588,
0.010680743,
0.0063771713,
-0.0032565726,
0.030267768,
0.020287292,
0.010014471,
0.023577858,
0.003824263,
0.02548149,
0.015473818,
0.0005179752,
0.018601216,
-0.0150523,
0.05215955,
-0.022068549,
0.032497738,
-0.0053301733,
0.013502198,
0.016208077,
0.006564135,
-0.016656792,
-0.0026956806,
0.02418974,
-0.0068700765,
0.00539816,
-0.021524653,
0.021783004,
-0.015242663,
-0.005622517,
-0.011415001,
-0.01219685,
-0.0048032748,
0.013903322,
0.012230843,
-0.017771777,
-0.024815219,
-0.0030271169,
0.027534695,
-0.017730983,
0.011965695,
-0.013400218,
-0.03959557,
0.028309746,
-0.009463777,
0.014549197,
0.0079272725,
-0.021307094,
0.034374177,
0.012149259,
0.013774146,
0.0036678934,
-0.019947357,
0.003909247,
0.012339623,
-0.008729518,
-0.005489942,
0.039051678,
-0.0026327928,
0.0010232029,
-0.029696679,
0.04854265,
0.012727148,
0.0025240136,
0.03924204,
0.003343256,
-0.00902866,
0.0025987993,
-0.0074241697,
0.0332048,
0.023033962,
-0.003919445,
0.006846281,
-0.008729518,
0.01790775,
-0.02242208,
-0.012101669,
0.011326618,
-0.0025376112,
-0.0021500858,
0.02564466,
0.048515454,
0.04158079,
0.009579354,
0.004714892,
-0.008559551,
-0.013617776,
0.0062038046,
-0.00056174176,
0.00918503,
-0.0009161235,
0.008940278,
0.0043885545,
0.00054686965,
0.0017455637,
-0.003902448,
-0.016167285,
0.0047726803,
0.0072134105,
-0.02444809,
0.040574584,
0.018383658,
0.014032496,
-0.021619834,
-0.037827913,
0.046747793,
0.013155465,
-0.00056131685,
-0.018315671,
-0.027493903,
-0.0037358801,
-0.021769406,
-0.0027075782,
-0.0045857164,
0.026909215,
-0.020858381,
0.020260097,
-0.017554218,
-0.030594105,
0.04587756,
0.0051670047,
-0.005578325,
-0.008960674,
0.0046673007,
0.024298519,
-0.037501574,
-0.006961859,
0.008491564,
0.0019597225,
-0.015908934,
-0.034809295,
0.0046571027,
0.008287603,
0.025427101,
0.002092297,
0.010334009,
-0.027167566,
0.010837113,
0.017894153,
-0.023033962,
-0.001292601,
0.009694932,
-0.0113470135,
-0.0039126463,
-0.004069016,
-0.0066559175,
0.0072066113,
0.03124678,
0.015473818,
0.0019546235,
-0.0021619834,
-0.0080428505,
0.0045551225,
0.0044089505,
-0.022177327,
-0.006805489,
-0.00065904803,
-0.0080632465,
-0.0121288635,
0.007193014,
0.005435553,
0.02340109,
0.01162576,
-0.019077124,
-0.0352988,
0.017010322,
-0.026746048,
0.015908934,
0.012054077,
0.005143209,
0.013461406,
0.0207632,
0.0031443941,
0.021511056,
0.02485601,
0.027031591,
-0.009273414,
0.005955653,
-0.021715017,
-0.010130049,
0.038235832,
-0.00034269647,
-0.015609792,
0.0053743646,
-0.020899173,
0.00092377205,
0.012258038,
-0.015283455,
0.00024347809,
0.013515796,
-0.0005103267,
-0.0041879932,
-0.02393139,
0.008498362,
0.0063363793,
-0.007934071,
-0.019430656,
0.0009450179,
0.007349384,
-0.00918503,
-0.019525839,
0.015174677,
0.0062989863,
-0.008545954,
-0.018342866,
-0.001391182,
-0.026759645,
-0.014114081,
-0.029044004,
-0.006397567,
-0.017934944,
-0.02678684,
-0.022925183,
-0.0090218615,
-0.022762015,
-0.00064715033,
-0.002423733,
0.0061426167,
-0.017377453,
-0.021674225,
0.003929643,
0.0051636053,
0.002201076,
0.0032021832,
0.0025036177,
0.015025105,
0.051506877,
-0.019974552,
-0.022775613,
-0.028826445,
0.0025920006,
-0.0072270078,
-0.018614814,
0.023278715,
-0.019321878,
-0.019756993,
0.008307999,
0.01998815,
-0.022748418,
0.010449586,
-0.03431979,
-0.018614814,
0.011775332,
-0.011666552,
0.01188411,
0.018342866,
-0.0004121706,
-0.010136847,
-0.0076757213,
0.005143209,
-0.046285484,
-0.005455949,
0.009096648,
0.023265118,
0.016072104,
-0.0047726803,
-0.009212225,
0.008627538,
-0.005897864,
-0.046095118,
0.006587931,
0.014073289,
0.013903322,
-0.016833557,
0.039214846,
-0.031029223,
-0.02947912,
-0.0074989554,
-0.014589989,
0.034129426,
0.002999922,
-0.010130049,
0.005054826,
0.014127678,
-0.012543583,
-0.013420614,
-0.006866677,
0.0026548884,
0.018070918,
-0.004228785,
-0.031437144,
-0.022965975,
-0.0015475518,
-0.034129426,
0.010184438,
-0.028119383,
-0.014372431,
-0.014290847,
0.007845689,
-0.036767315,
0.012584375,
0.008559551,
-0.015215469,
-0.0096269455,
-0.014100484,
0.0144540155,
0.020953562,
0.008885888,
-0.010102853,
-0.038942896,
-0.019117916,
-0.011251832,
-0.042750165,
-0.018152503,
-0.010789521,
-0.01645283,
0.0004223686,
0.02465205,
0.013604179,
-0.012890317,
-0.0022622643,
0.005391361,
0.016126493,
0.0130670825,
0.000112178386,
-0.02833694,
0.0031188992,
-0.019852174,
-0.0023965384,
0.025753438,
0.0042899735,
0.001126033,
-0.01427725,
0.0034809294,
0.002575004,
-0.0027075782,
0.00482707,
-0.004708093,
-0.0040112273,
0.0062411977,
-0.008987868,
-0.020287292,
-0.019335475,
-0.0022554654,
0.030131795,
0.034075037,
0.00752615,
0.027235553,
-0.0143180415,
0.014997911,
-0.0046571027,
0.0071998127,
-0.0055987216,
0.00017060463,
-0.005506939,
-0.019743396,
0.011802526,
0.01354979,
0.015908934,
-0.015609792,
0.0017897552,
-0.0076689227,
0.0069312644,
-0.017989334,
0.018628411,
-0.005401559,
0.003093404,
-0.014236457,
0.006873476,
0.0059760488,
-0.008240012,
0.00022584399,
0.025767036,
0.003191985,
0.029832652,
-0.015636988,
0.004116607,
0.0059862467,
-0.032987244,
0.02465205,
0.007900078,
0.018070918,
0.005408358,
0.015487416,
0.0029744268,
-0.007396975,
-0.01121104,
0.0004712342,
0.016711181,
0.027847435,
0.013624575,
0.021184718,
0.006462155,
-0.0064791515,
-0.0111906435,
-0.035325993,
0.012244441,
0.0133594265,
-0.014698768,
-0.018247684,
0.011415001,
-0.0033364573,
0.016235271,
0.004262779,
-0.008729518,
0.007485358,
-0.019009138,
-0.020355279,
0.014984313,
0.0006403516,
0.020355279,
-0.0049494463,
0.018342866,
0.01754062,
-0.016955933,
-0.00664232,
0.011258631,
-0.0069346637,
0.013005895,
-0.0011311321,
0.011931702,
-0.0007801497,
0.0028945424,
0.015473818,
0.0076213316,
-0.0015144083,
0.034537345,
0.007193014,
-0.0025240136,
0.01146939,
-0.016330454,
0.030458132,
-0.009973679,
0.002428832,
-0.0022503664,
-0.016031312,
-0.002979526,
0.0032463747,
0.013760549,
-0.017091908,
0.0014175269,
-0.0010198036,
-0.024720037,
-0.0166024,
0.003861656,
0.017159894,
-0.0420431,
0.0010206534,
-0.012332824,
-0.003980633,
0.020164914,
-0.006234399,
-0.006608327,
-0.006700109,
0.013556588,
-0.021116732,
-0.0073901764,
0.011856915,
0.038806923,
-0.011306222,
0.01063995,
-0.019811383,
-0.053056978,
0.025100764,
-0.023673039,
-0.021429472,
-0.019444253,
0.0017608608,
0.009375393,
0.016439233,
-0.026093373,
0.021524653,
0.0025716044,
0.024869608,
-0.008165227,
-0.032524932,
0.01053797,
-0.020844784,
-0.00021862038,
0.044762574,
-0.01805732,
-0.01691514,
-0.017268673,
0.0043681585,
0.036359396,
-0.046883766,
0.025440698,
-0.012557181,
0.016330454,
-0.023795415,
0.010313613,
0.013352628,
0.0011489786,
-0.019947357,
0.019974552,
-0.0033551536,
-0.0016928739,
-0.02564466,
-0.017105505,
-0.018968346,
0.015528209,
-0.02107594,
-0.0041234056,
-0.009354997,
0.019376267,
-0.050201528,
-0.011462592,
-0.01100028,
0.010191237,
0.005931857,
-0.03334078,
-0.002097396,
-0.038888507,
-0.046149507,
0.01380814,
-0.0217966,
0.017703788,
-0.007866085,
-0.012292032,
-0.010993482,
0.01722788,
0.018193295,
-0.018900359,
-0.03222579,
-0.015868142,
0.019553034,
-0.014386028,
0.029859846,
0.010837113,
-0.045660004,
0.0042423825,
0.010082457,
-0.029098393,
-0.018410852,
0.029914238,
-0.003596507,
-0.0040452206,
-0.00134954,
-0.007954467,
-0.016330454,
-0.012631967,
0.0058264774,
0.0052451896,
0.0066559175,
0.0065267426,
0.011979292,
-0.005952253,
-0.0063771713,
0.025984595,
0.014522002,
0.0259438,
-0.025236737,
-0.018601216,
0.0007074887,
-0.0015653984,
-0.018043723,
0.039405208,
0.017472634,
-0.002320053,
-0.005133011,
-0.012999096,
-0.026814034,
0.014644379,
-0.03837181,
-0.0068122875,
0.030893248,
-0.028935226,
-0.0152562605,
0.023645844,
-0.0006581982,
-0.012659161,
-0.01074193,
-0.012978699,
0.00010128986,
-0.013801341,
0.011673351,
0.044816967,
-0.0042423825,
0.0024696242,
-0.013556588,
0.0049120537,
0.009327803,
-0.031518728,
0.019213099,
-0.026365321,
0.0036916886,
-0.013271043,
-0.025903009,
0.02688202,
-0.001827148,
0.00040919616,
-0.0012883518,
0.010769125,
0.17926787,
0.003316061,
-0.002573304,
0.03073008,
0.013332231,
0.021456666,
0.016398441,
0.016085701,
-0.0015093092,
-0.015664183,
-0.011061469,
0.0038140651,
-0.028880836,
-0.0070094494,
0.0031698893,
-0.0028758459,
-0.030376548,
-0.01993376,
-0.016588803,
-0.0067544985,
0.008804304,
-0.0025512085,
0.013169063,
0.0071862154,
0.010871106,
0.009402588,
-0.0057516918,
-0.019172307,
0.025903009,
0.009871698,
-0.0243937,
0.0004208814,
0.01796214,
0.0059726494,
-0.007614533,
0.008675128,
-0.015269858,
-0.015922531,
-0.006530142,
0.018030126,
-0.0061800093,
-0.0038888508,
-0.032198597,
-0.018193295,
-0.020314487,
0.01416847,
-0.0028316544,
-0.025903009,
0.0038650553,
-0.010442788,
-0.032824077,
-0.0011880711,
0.01531065,
0.017635802,
-0.014345236,
0.0065029473,
0.0080428505,
-0.019906566,
-0.0027840636,
0.044980135,
0.0026718853,
0.011918104,
-0.030485326,
0.015011508,
-0.014399625,
0.013468205,
-0.0075193513,
0.0008081943,
0.008314798,
-0.0073901764,
0.023169937,
0.009776517,
-0.041009698,
0.019716201,
-0.012217246,
-0.019335475,
0.029288758,
0.020001747,
0.0052077966,
0.02485601,
-0.01448121,
0.00013905446,
0.02133429,
-0.002845252,
-0.01588174,
-0.018614814,
0.021660626,
-0.0003575686,
-0.016548011,
0.005092219,
0.0039772335,
-0.013060284,
-0.016072104,
0.011081865,
0.019838577,
-0.02739872,
-0.014304444,
0.0045789178,
-0.005792484,
0.008158429,
-0.016248869,
0.067497395,
0.007832091,
-0.0071590208,
0.0038582566,
0.011129456,
-0.005853672,
0.023754623,
-0.0016427335,
0.002678684,
0.0056871045,
-0.03867095,
0.015242663,
-0.017377453,
0.006305785,
0.009769718,
0.008858693,
-0.012557181,
0.0021262902,
-0.018818775,
0.010945891,
-0.010728333,
0.0015730469,
0.017894153,
-0.019689007,
0.013563387,
-0.02953351,
-0.0039228443,
0.0015042102,
-0.019648215,
-0.0019682208,
-0.024012974,
-0.007988461,
-0.028119383,
-0.0058604707,
0.008790706,
0.020980759,
0.003783471,
0.00006262231,
0.016656792,
-0.003861656,
0.011686948,
0.008749914,
0.020559238,
0.013386621,
-0.02221812,
0.002274162,
-0.0017642601,
-0.0074649616,
0.0018679401,
-0.043919537,
-0.006740901,
0.007832091,
0.00752615,
0.038344614,
-0.007655325,
-0.0100960545,
-0.036876094,
-0.005775487,
0.0176494,
-0.039459597,
-0.013189459,
0.020532044,
-0.020749602,
-0.0070230467,
0.0075805397,
-0.17219722,
0.021361485,
0.028636083,
-0.0285545,
0.036468174,
0.021089537,
0.032416154,
0.012428005,
-0.02625654,
0.005799283,
0.00648595,
0.005489942,
-0.028826445,
-0.008002059,
0.014916326,
-0.0121288635,
-0.007811695,
0.0010937393,
0.022068549,
0.0011659754,
0.0025087167,
-0.026066178,
0.023890598,
-0.015038703,
0.0018152503,
0.026637267,
-0.02170142,
-0.0025359115,
0.014114081,
-0.007804896,
-0.0306213,
0.0037154842,
0.023632247,
0.0050276313,
0.016575206,
0.010170841,
0.0018815375,
0.0029081397,
-0.011761734,
0.02413535,
0.008851894,
0.005044628,
-0.019090721,
0.0053641666,
-0.026270138,
-0.00877031,
-0.0012475597,
-0.0066457195,
0.004905255,
0.016548011,
0.009749321,
-0.016221674,
0.033395167,
0.019213099,
0.027031591,
-0.012176454,
-0.009429784,
-0.019036332,
0.00097306253,
-0.010130049,
0.0029863247,
-0.0014404724,
0.0060848277,
0.0076689227,
0.012516389,
-0.046095118,
-0.025250334,
-0.019702604,
-0.021579042,
-0.0013571886,
-0.008525558,
-0.012869921,
0.0018390457,
-0.024624856,
0.011047872,
0.027317137,
0.004249181,
0.020273695,
0.04473538,
0.008437174,
0.002501918,
-0.01416847,
-0.028772056,
-0.0007665523,
-0.00080182054,
0.0050072353,
0.012434804,
0.0070026508,
0.0061494154,
-0.013271043,
0.0013350928,
-0.013760549,
-0.013345829,
-0.030077405,
0.015242663,
0.016683986,
-0.0063193827,
0.0016860751,
0.00461971,
-0.025726244,
0.013678964,
-0.0061902073,
-0.019525839,
-0.015025105,
0.04495294,
0.0025767037,
-0.025889412,
0.009592952,
0.016316857,
0.007566942,
-0.013162264,
-0.013427413,
0.003831062,
0.035951473,
-0.017323062,
0.0049018557,
0.0027551693,
-0.014073289,
0.00503443,
0.0011302822,
0.049630437,
-0.0072881957,
0.015351443,
0.0058944644,
-0.023496274,
-0.024352908,
-0.11824282,
-0.043674786,
0.015908934,
0.020749602,
-0.016751973,
0.005455949,
-0.018302074,
0.034754906,
-0.007172618,
0.029941432,
-0.0041675973,
-0.027276345,
-0.0076213316,
-0.023863403,
0.010476781,
0.017105505,
0.013508997,
0.0009212225,
-0.016330454,
0.035353187,
0.009878497,
-0.006587931,
0.008328396,
-0.0104087945,
0.0009917589,
-0.013916919,
0.0026191953,
0.026215749,
0.007886481,
0.0050412286,
0.013508997,
-0.013978107,
0.048760206,
0.015106689,
-0.010401996,
-0.00050012866,
0.014834742,
-0.031219585,
0.03140995,
-0.009980477,
-0.0063567753,
-0.01308068,
0.029995821,
-0.01681996,
0.0013257446,
-0.029506315,
-0.038779728,
0.018655606,
0.035054047,
0.004245782,
-0.004062217,
-0.026977202,
-0.000018151972,
-0.024842413,
0.025304725,
0.009416186,
0.0023659442,
0.025508685,
-0.017880555,
-0.0059386557,
0.0072745983,
-0.010503977,
-0.028282551,
0.0121084675,
0.02896242,
0.0022333697,
-0.017295867,
-0.034700513,
0.012360019,
0.0108575085,
-0.019253891,
0.009069453,
-0.0010826914,
0.014426821,
-0.034809295,
0.0054151565,
0.01115665,
-0.0306213,
-0.010136847,
0.0012535085,
-0.03334078,
-0.02901681,
-0.0050956183,
-0.012346421,
-0.0012849524,
0.0065267426,
0.012203649,
0.022136535,
0.010497178,
-0.02346908,
0.0017098705,
0.029914238,
-0.00581288,
-0.0024560269,
-0.0028792452,
-0.01396451,
-0.030403743,
-0.008641135,
0.025658257,
0.015133884,
-0.0202465,
-0.036468174,
-0.059665304,
0.0051908,
0.009660939,
0.0045245285,
0.00050777715,
-0.004371558,
0.036631342,
0.005133011,
0.0008761812,
-0.025563074,
-0.017690191,
0.0090014655,
-0.016031312,
-0.032552127,
-0.027181163,
-0.00002091394,
0.021443069,
0.00087533135,
0.028527305,
0.013019492,
-0.0031953843,
-0.03078447,
-0.016398441,
0.010959488,
-0.0049324497,
0.0008812802,
-0.027289942,
0.011027476,
-0.018234087,
0.019879369,
0.0048746606,
-0.0016044909,
0.0040316232,
0.0040214253,
-0.0040656165,
0.00996688,
-0.016262466,
0.019920163,
0.014875534,
0.0061392174,
-0.004640106,
-0.021239107,
0.029805457,
-0.006710307,
-0.012088071,
-0.0113470135,
-0.040737752,
0.0033976454,
0.02117112,
-0.026446905,
0.013678964,
0.0054525496,
0.008185623,
-0.0342654,
-0.028146578,
-0.016887946,
-0.0024849211,
-0.0031138002,
-0.022721222,
-0.025032777,
0.024516076,
0.020545641,
-0.015025105,
-0.012740745,
0.009735724,
0.0039126463,
-0.013271043,
-0.00503443,
-0.0058604707,
-0.00679869,
-0.010361204,
-0.022014158,
-0.006421363,
0.007172618,
-0.013950912,
-0.0033092625,
-0.012863122,
0.0066151256,
-0.015501014,
0.0032310775,
0.012829129,
-0.0090218615,
-0.03208982,
-0.00005006067,
0.0011013878,
0.028744861,
-0.02833694,
0.016398441,
-0.020110525,
0.016643193,
0.0152562605,
-0.009334601,
0.014902729,
0.0046978947,
0.00024687743,
0.023387494,
0.017241478,
-0.011639358,
0.015174677,
0.0009118743,
0.0058468734,
0.005612319,
-0.007832091,
-0.005833276,
-0.0014923125,
-0.018900359,
-0.041308843,
-0.052676253,
-0.010028068,
0.0049426476,
0.041118477,
0.03524441,
0.02133429,
0.0008434625,
-0.0028758459,
0.038072664,
-0.007961266,
0.023346702,
-0.01728227,
0.018560424,
0.00062462967,
0.009524965,
0.018873164,
-0.009837705,
0.030648496,
-0.018560424,
0.029941432,
-0.018587619,
0.018016528,
-0.00073680806,
0.016887946,
0.0166024,
-0.021891782,
0.0088654915,
-0.009769718,
-0.0154330265,
-0.024352908,
0.018342866,
-0.012054077,
0.0918639,
0.012713551,
-0.04541525,
-0.018410852,
0.01204048,
0.016031312,
-0.006700109,
0.036468174,
-0.007974864,
-0.008110837,
0.024352908,
-0.015229066,
0.023482677,
-0.028527305,
-0.01842445,
-0.002994823,
0.0096065495,
0.0081992205,
0.008579947,
-0.00047250895,
0.026596475,
-0.035489164,
0.0063601746,
-0.010735132,
-0.026705256,
-0.0002190453,
0.0069686575,
-0.009266615,
-0.022272509,
-0.019090721,
0.006118821,
-0.002107594,
-0.038018275,
0.0017158195,
0.0013061983,
-0.0025954,
-0.011945299,
0.0061392174,
0.023101948,
0.011068268,
0.019090721,
0.024720037,
-0.024162544,
-0.018818775,
-0.0011846718,
-0.013175862,
0.020205706,
-0.0072745983,
-0.028826445
] |
Recombination-dependent DNA replication, often called break-induced replication (BIR), was initially invoked to explain recombination events in bacteriophage but it has recently been recognized as a fundamentally important mechanism to repair double-strand chromosome breaks in eukaryotes. This mechanism appears to be critically important in the restarting of stalled and broken replication forks and in maintaining the integrity of eroded telomeres. Although BIR helps preserve genome integrity during replication, it also promotes genome instability by the production of loss of heterozygosity and the formation of nonreciprocal translocations, as well as in the generation of complex chromosomal rearrangements | [
-0.04440585,
-0.0118746,
-0.017669829,
-0.013328363,
-0.02265227,
0.017022243,
0.003389911,
-0.001486803,
-0.010526566,
-0.011504551,
-0.008412002,
0.006717046,
0.0033205268,
0.0055639474,
-0.007804064,
-0.00060132926,
0.030581888,
0.0046619535,
0.005487955,
0.011240231,
-0.035313226,
0.0014017249,
0.001926236,
-0.015396671,
0.007242383,
0.014048637,
0.017828422,
-0.033674438,
-0.010064005,
0.0075595677,
0.0082534095,
0.0020220522,
-0.000104850595,
-0.0011299703,
-0.017246915,
-0.011193975,
0.030740479,
-0.008834914,
0.0035418954,
-0.022599407,
0.012555226,
0.01007722,
-0.01633501,
0.017312996,
-0.017379075,
0.013678588,
0.013235851,
-0.01969188,
0.011279879,
0.008306273,
0.022705136,
0.0052467627,
-0.027119288,
0.010771062,
-0.01057943,
-0.0017263435,
0.00035848474,
0.018819623,
0.012978138,
-0.019202888,
-0.009376772,
-0.0010382842,
-0.015053055,
0.0016214413,
-0.000026509493,
0.012138921,
0.03137485,
-0.011927465,
0.005269891,
-0.0007830496,
0.03755995,
0.022824079,
0.0021971646,
-0.0010911482,
0.009350339,
-0.035075337,
-0.0026068613,
-0.015026623,
-0.0006736044,
0.016480386,
0.01839671,
0.012786507,
-0.005385531,
0.032458562,
-0.0032461868,
-0.02059057,
-0.0057522757,
0.018370278,
0.00831949,
0.005742364,
0.008907602,
0.024780052,
0.021449612,
0.014683006,
-0.017987013,
0.01986369,
0.0080023045,
0.030581888,
-0.0037037916,
-0.02431749,
-0.021449612,
-0.007903185,
0.0012588266,
-0.006905374,
-0.020934187,
-0.0041333125,
0.024145681,
-0.04078466,
-0.003915248,
-0.010757846,
-0.023947442,
0.01677114,
-0.013149947,
-0.022876943,
0.035418954,
-0.0031586306,
0.0113856075,
-0.012647738,
-0.015660992,
-0.014352606,
0.03227354,
0.0023541048,
-0.002444965,
-0.023537744,
0.017920934,
-0.0017874677,
-0.016995812,
0.006892158,
0.011200584,
-0.0052236347,
0.018528871,
0.014854815,
-0.0009242959,
0.012337161,
-0.025269045,
0.010163125,
-0.0015586652,
-0.025691956,
-0.020246955,
-0.024938643,
0.011412039,
0.019929769,
-0.008590418,
-0.017960582,
-0.0055507314,
0.017788773,
-0.0029868223,
0.007830496,
0.0076322556,
0.002884398,
-0.0032428827,
0.0069780624,
0.014061853,
0.0080948165,
0.010090437,
0.024502514,
-0.01074463,
0.012152137,
-0.021330668,
-0.016282145,
0.0056432434,
-0.01975796,
0.009409811,
-0.0020319642,
0.017735908,
0.036079753,
-0.025308693,
0.01567421,
0.016017824,
-0.034784585,
-0.005808444,
0.013982557,
-0.04165692,
0.030608319,
-0.023273423,
0.021581773,
-0.0039648083,
-0.000009679708,
-0.021277804,
-0.0065716696,
-0.014048637,
0.00667079,
0.03385946,
0.015608128,
-0.0230884,
0.008147681,
0.00288605,
-0.015727073,
-0.016295362,
0.000493536,
-0.014008989,
0.000473712,
0.0069450224,
-0.017907716,
-0.6326777,
-0.009211571,
-0.020286601,
-0.009218179,
0.005263283,
0.023960657,
0.0037004875,
0.020498058,
-0.0005885262,
0.01806631,
-0.009343731,
-0.011702792,
0.020709515,
-0.01806631,
-0.03253786,
-0.04770986,
0.00194606,
-0.006793038,
0.013149947,
0.016031042,
-0.020841675,
-0.0037236158,
-0.012766683,
0.0040705362,
-0.011451688,
-0.010354757,
0.02973606,
0.0076058237,
0.0030875944,
0.018039877,
-0.011200584,
0.017392293,
-0.009310692,
-0.023246992,
0.06021222,
0.016520035,
0.013282107,
0.034890313,
0.026022358,
0.038220752,
0.006356909,
0.007367935,
0.04028245,
0.009257827,
0.0040639285,
0.010923047,
0.005858004,
0.004959314,
-0.0004311729,
-0.008068385,
0.0039846324,
0.024991509,
-0.017246915,
0.018158821,
0.02957747,
0.036872715,
0.016057473,
-0.030476158,
0.021198507,
-0.00035580024,
-0.0134407,
0.037665676,
0.007923008,
-0.008233585,
-0.006310653,
-0.0045132735,
-0.012991355,
-0.006317261,
0.01716762,
-0.014947327,
0.018647814,
0.023392368,
0.02418533,
-0.013453916,
-0.011266664,
0.016572898,
-0.002367321,
0.02111921,
0.0025391292,
0.0050584343,
0.012310729,
-0.018053094,
-0.018515654,
0.006366821,
0.042000536,
-0.021568557,
-0.0124230655,
0.013678588,
-0.016295362,
-0.014630143,
0.009218179,
-0.0130442185,
-0.0009945061,
-0.011623496,
-0.0074934876,
0.008563986,
-0.0030479464,
-0.01633501,
-0.00095650996,
-0.016216066,
-0.008900994,
-0.018145606,
-0.015978176,
0.017854853,
0.0076652956,
0.011848168,
-0.012548618,
-0.0123305535,
0.032326404,
-0.01543632,
0.004298513,
-0.006773214,
0.004467017,
0.010149909,
-0.00977986,
-0.027053207,
0.03140128,
0.003872296,
0.018383494,
-0.014577278,
0.0108107105,
-0.029180989,
-0.0068525104,
-0.026035573,
0.021185292,
-0.000024844583,
0.013771101,
0.0027836259,
0.0010168081,
-0.00065378036,
-0.020273386,
-0.0035187672,
0.008464865,
-0.0041663526,
0.012449497,
0.015991393,
0.004794114,
-0.011253447,
0.01144508,
-0.031163393,
-0.019744745,
-0.002456529,
0.01819847,
0.010070613,
-0.0135728605,
-0.013533212,
-0.023114832,
-0.015079487,
0.021343885,
-0.005782012,
0.023471665,
0.000020391917,
-0.027542202,
0.019797608,
0.0015446232,
-0.01001114,
-0.0095684035,
-0.044670172,
-0.017352644,
-0.011649928,
0.0034956392,
0.018859271,
0.0061553647,
-0.011174151,
0.0009375119,
-0.02212363,
0.02195182,
-0.0020815243,
0.0055143875,
-0.037903566,
0.013823965,
-0.002924046,
-0.03663483,
-0.00090860185,
0.007896576,
0.026471702,
-0.015660992,
0.016149985,
0.00894725,
0.0019130199,
-0.0031916706,
-0.02015444,
-0.025440853,
-0.018158821,
-0.00020371267,
0.0065188054,
0.033727303,
-0.014458334,
0.027198585,
0.035974026,
0.003885512,
0.035974026,
0.013143339,
-0.0031388064,
0.019520072,
-0.021502476,
-0.018687462,
0.029154556,
0.0034559912,
0.030317567,
0.02565231,
-0.0030578582,
0.016837219,
-0.025480501,
0.018938567,
-0.013130123,
0.011597064,
-0.018542087,
0.018211685,
-0.0007244035,
-0.010017749,
-0.002435053,
0.0027026776,
-0.009541972,
0.0002465615,
0.018079525,
-0.011451688,
0.015489184,
-0.004731338,
-0.004959314,
-0.014656574,
0.012165353,
0.023075184,
0.006892158,
-0.006300741,
0.0046487376,
0.009317299,
-0.005927388,
0.010890006,
0.0025110452,
0.0081410725,
0.02984179,
0.0056300275,
0.004229129,
0.006938414,
0.018713895,
0.013328363,
0.009092627,
0.034811016,
0.003399823,
0.0035815435,
0.030185407,
-0.0016908254,
-0.004711514,
0.031586304,
0.011583848,
0.019652233,
0.02045841,
-0.018674247,
0.012766683,
-0.032458562,
-0.0050650425,
-0.03835291,
0.028599484,
0.023233777,
-0.026405623,
0.016163202,
-0.010315109,
0.055718772,
0.0044934493,
-0.004843674,
-0.00874901,
0.014299742,
-0.019150024,
0.0057853158,
0.0065088933,
0.013863613,
-0.0056630676,
-0.025454069,
0.0014801951,
0.0012530446,
-0.009191747,
0.014960543,
-0.015357024,
0.011167543,
0.010552998,
-0.016361441,
0.022969456,
-0.0026399014,
-0.008524338,
-0.006274309,
-0.038432207,
0.03629121,
0.019929769,
-0.0075727836,
0.003994544,
-0.010315109,
0.005808444,
0.0020798724,
0.016083905,
-0.0030413382,
0.018779974,
0.014828383,
0.034282375,
-0.012185177,
-0.022572974,
0.021885742,
-0.030449728,
0.01556848,
-0.009984708,
0.0059868605,
0.037665676,
-0.008782051,
-0.0029372622,
0.027462905,
-0.012310729,
0.018938567,
0.00053648814,
-0.020365898,
-0.019982634,
-0.0010448921,
-0.007612432,
-0.013394443,
-0.0523619,
-0.0038822081,
-0.004443889,
-0.017458372,
-0.0114781195,
-0.0010448921,
-0.0013645549,
-0.034388103,
-0.021965038,
-0.0060066846,
0.0060958927,
0.039304465,
0.022361519,
-0.03087264,
0.03835291,
-0.017022243,
0.01975796,
0.017048676,
-0.045621727,
0.01975796,
-0.04004456,
0.014405469,
-0.020934187,
0.022612622,
0.009535364,
-0.0027869297,
0.019599369,
0.013354796,
-0.02212363,
-0.024542162,
-0.009026547,
-0.008696146,
0.006779822,
0.03470529,
0.024621459,
0.0029769102,
-0.01131292,
0.024079602,
0.020815244,
-0.00015291356,
-0.013705021,
-0.02970963,
0.006690614,
-0.010229205,
0.026524566,
0.018938567,
-0.028969532,
0.018568518,
-0.0036608395,
-0.01999585,
-0.007130047,
0.0038987282,
0.010513349,
0.017484805,
0.013876828,
0.015779937,
-0.0248197,
-0.0002967411,
0.0005199681,
-0.031559873,
-0.014075069,
0.028388027,
-0.0009251219,
-0.035709705,
-0.026194166,
0.0041035763,
-0.005329363,
0.008537553,
-0.010890006,
-0.019810826,
-0.013823965,
-0.020313034,
-0.026868183,
0.021740366,
0.0076190396,
0.008418609,
-0.01743194,
0.003389911,
-0.027991546,
-0.02002228,
-0.007354719,
-0.01955972,
-0.051172458,
-0.040705364,
-0.013282107,
0.013163163,
-0.0019757962,
0.02681532,
-0.016837219,
-0.021740366,
0.008147681,
-0.007870144,
-0.01889892,
0.008524338,
-0.029154556,
-0.0079097925,
0.018277766,
-0.011762264,
-0.005699412,
-0.025427636,
0.0085309455,
0.010486918,
-0.0015735333,
0.046256095,
-0.0066608777,
-0.011663144,
0.03177133,
0.024476083,
0.02431749,
0.01144508,
-0.021105995,
-0.0025424333,
-0.01653325,
-0.016348226,
-0.017656613,
-0.0139429085,
-0.019467209,
-0.02232187,
0.009066194,
-0.008028736,
-0.009508932,
0.0045859613,
-0.012132313,
0.009231395,
0.018912135,
0.022506895,
0.022374734,
0.009086018,
0.0037830877,
-0.0061487565,
-0.01260809,
-0.0017445156,
-0.024476083,
0.0039515924,
0.009092627,
-0.014154365,
0.014973759,
0.0045397053,
-0.024912212,
-0.02026017,
0.0032841829,
-0.009105843,
0.028203003,
0.0005472261,
-0.018991431,
-0.025771253,
-0.0056102034,
-0.00030851163,
0.0018304198,
-0.009423028,
-0.033013638,
-0.0049097543,
0.008914211,
0.025956277,
-0.016863652,
-0.00871597,
-0.025612662,
0.010738023,
0.018383494,
-0.0059868605,
0.0036145835,
0.0007136655,
-0.015251296,
-0.017220484,
-0.013982557,
-0.01640109,
-0.036529098,
-0.00055094314,
-0.012594874,
0.032326404,
0.02764793,
0.03882869,
-0.008782051,
-0.00051088206,
0.03010611,
0.006016596,
-0.019929769,
-0.0069714542,
-0.0032247107,
-0.024898995,
0.008352529,
0.0066972217,
0.002433401,
-0.0032660107,
-0.010030964,
0.014101502,
0.019044295,
-0.0031074185,
-0.015779937,
0.012006761,
-0.020061929,
-0.01613677,
-0.0026266854,
-0.0001922519,
0.005388835,
-0.014286526,
0.00488993,
0.011398824,
-0.011266664,
0.038379345,
0.011266664,
0.024238193,
0.006812862,
0.038934417,
-0.016784355,
0.039542355,
-0.035313226,
-0.01180852,
-0.023643473,
-0.009608052,
0.024978291,
0.017061891,
0.0030347302,
0.0012670866,
-0.000486515,
-0.0015066271,
0.0010870183,
-0.017616965,
-0.014392254,
-0.0054846513,
0.006333781,
0.014418686,
-0.013308539,
-0.004295209,
-0.021700718,
0.008365746,
0.0009094279,
-0.019110376,
0.020365898,
0.015158784,
0.004206001,
0.03113696,
0.0036112794,
0.012019977,
-0.0036377115,
0.037744973,
0.0010647163,
-0.00047164698,
-0.015171999,
0.007995697,
-0.0026101654,
-0.00199562,
0.01626893,
0.03227354,
-0.0054978672,
-0.034388103,
0.0040308884,
-0.008187328,
-0.017616965,
-0.030687615,
0.007341503,
-0.00021372794,
0.00047536398,
-0.013090475,
0.012297513,
-0.0006190883,
-0.0016503514,
-0.014048637,
0.045330975,
0.025586229,
-0.02611487,
-0.015198431,
0.011590456,
-0.012356985,
0.0070177107,
-0.036211915,
-0.01776234,
-0.012449497,
-0.02398709,
-0.0013182987,
-0.0021674284,
0.0064461175,
0.0121455295,
-0.012978138,
-0.015634561,
0.011372391,
0.0020204003,
-0.010638902,
-0.028810939,
-0.0069714542,
0.03742779,
-0.0018205078,
-0.0035352872,
-0.018713895,
-0.0010275461,
0.013031003,
0.0009689,
-0.014749086,
-0.0006868204,
-0.021264588,
0.014339389,
0.016652195,
0.020471627,
0.011048599,
-0.009271043,
-0.008015521,
0.010784279,
-0.030634752,
-0.0107644545,
0.035709705,
-0.03806216,
-0.0065155015,
-0.00095485797,
0.02618095,
0.026577432,
0.0020699603,
0.015951745,
0.0022103805,
0.036238346,
-0.013784316,
0.000007866375,
0.0064923735,
0.0045892657,
-0.012660954,
0.00971378,
0.014947327,
0.02232187,
0.0008198067,
0.009363555,
-0.010440662,
0.0053690113,
-0.0039879363,
0.011154327,
0.006195013,
-0.030053247,
0.027832953,
-0.018674247,
0.0079097925,
-0.010030964,
-0.014881247,
0.0054681315,
0.0016553074,
0.006267701,
0.016837219,
-0.01986369,
-0.0145640625,
-0.008273233,
0.01613677,
-0.0021013482,
-0.005302931,
-0.015978176,
0.0010159821,
-0.005332667,
-0.006152061,
-0.008497906,
-0.006611318,
0.0035716314,
-0.018238118,
0.0060265083,
-0.0060331165,
-0.00958162,
-0.019216103,
0.005319451,
0.0130442185,
0.024991509,
0.009456067,
0.0022120327,
-0.007050751,
-0.015885664,
-0.033225093,
-0.012125705,
-0.0057291477,
0.02944531,
0.028097274,
-0.009839333,
-0.016850434,
-0.029101692,
-0.03396519,
-0.015119135,
0.0020666562,
0.0012018324,
0.013308539,
0.001473587,
-0.0025886893,
0.019665448,
0.005302931,
0.020180874,
0.017656613,
-0.0046289135,
0.026141303,
0.00944946,
0.021132428,
0.014616926,
-0.043745052,
-0.00020763619,
0.024079602,
0.005312843,
0.0050419145,
0.0101433005,
0.004206001,
0.037348494,
0.022506895,
0.0041696564,
0.02418533,
0.03169203,
0.012997963,
-0.026009142,
-0.033727303,
0.01806631,
0.014339389,
-0.02694748,
0.00064510736,
-0.021846093,
0.014484766,
0.011947289,
-0.035075337,
-0.010566214,
0.010123477,
-0.04541027,
0.012845978,
-0.0054483074,
0.02348488,
0.009660916,
-0.014656574,
-0.020630218,
-0.004853586,
-0.013004571,
-0.036106188,
0.0040573203,
0.012456106,
-0.010533174,
-0.013216027,
-0.005316147,
0.013255675,
-0.0060265083,
0.005511083,
0.005808444,
-0.018885704,
-0.027304312,
0.024291059,
0.013017787,
0.004543009,
-0.016625762,
0.014022205,
-0.032617155,
-0.01692973,
0.027832953,
-0.007083791,
-0.015859233,
0.037374925,
-0.013890045,
-0.018581735,
0.011564024,
0.010110261,
0.014775518,
-0.023894578,
0.012674171,
0.20109507,
-0.007790848,
0.018647814,
0.011174151,
-0.021476045,
-0.017735908,
0.0037368317,
0.0036211915,
-0.019546505,
0.0006050462,
0.018806407,
-0.003338699,
-0.019017864,
0.000965596,
0.017788773,
0.0020980444,
-0.008180721,
-0.0016875215,
-0.013242459,
0.0025688652,
0.029128125,
-0.014127933,
-0.030158974,
-0.015951745,
0.018224902,
0.0056068995,
-0.03161274,
0.0081410725,
0.008478082,
0.009271043,
-0.022837296,
-0.0058877403,
-0.0135728605,
-0.0013108647,
-0.011867993,
0.009211571,
0.0022269005,
-0.006690614,
0.0017577317,
-0.0032329706,
0.0050353063,
0.0213571,
0.012852587,
-0.01763018,
-0.01174244,
0.0145640625,
-0.01007722,
-0.016493602,
0.0027142416,
0.0027241537,
-0.045727454,
0.009575012,
-0.024780052,
0.036529098,
0.012984747,
-0.00030500113,
0.007777632,
-0.0001650971,
0.00668731,
0.009826116,
-0.011947289,
0.0032197547,
-0.032088514,
-0.0012654347,
-0.035339657,
0.02957747,
-0.027410042,
0.021185292,
0.029128125,
-0.030555455,
-0.0010738022,
-0.012925275,
-0.017788773,
0.0031140265,
0.0055837715,
-0.007995697,
0.03190349,
0.000961466,
0.026167734,
0.0113856075,
0.0050617387,
-0.010837142,
-0.023326289,
-0.012594874,
0.008352529,
-0.022824079,
0.01180852,
0.0011902684,
-0.019797608,
0.0074075833,
0.012178569,
0.0031107224,
-0.0037500476,
-0.0046421294,
0.008068385,
-0.002449921,
-0.022163277,
0.0037004875,
-0.011920856,
-0.0051112985,
-0.03679342,
0.07200091,
0.0070771826,
-0.017801989,
-0.0206963,
0.010883398,
0.0022434206,
0.001932844,
0.0057159318,
-0.0080948165,
0.00864989,
-0.006839294,
0.02249368,
-0.014484766,
0.0071102227,
0.013295324,
0.01633501,
-0.038511503,
0.018925352,
-0.004883322,
-0.0095684035,
-0.020445194,
0.00045264894,
0.012951707,
-0.031057665,
0.0061884047,
-0.011729225,
0.0121917855,
-0.016876867,
-0.011716008,
-0.0124230655,
0.010625686,
0.013916477,
-0.012740251,
0.018409926,
0.0018485918,
0.029524606,
-0.026088437,
-0.02957747,
0.005378923,
-0.00032028215,
0.0060033803,
-0.007334895,
-0.009304083,
-0.0070375344,
-0.015198431,
0.020379115,
0.009548579,
-0.01570064,
0.0020963924,
-0.02032625,
-0.019057512,
-0.0073613273,
0.0075133117,
0.0018551998,
-0.028625915,
-0.012522186,
-0.040335316,
0.012000153,
0.018555302,
-0.032749314,
0.0135728605,
0.007883361,
0.008200545,
-0.00858381,
0.0051443386,
-0.16546467,
-0.0027472817,
0.02618095,
-0.011048599,
0.037612814,
0.022374734,
0.0037533517,
0.018912135,
0.0054747392,
0.011160935,
0.01090983,
0.025242612,
-0.037586384,
-0.027172152,
-0.004837066,
0.0010589341,
0.009132274,
0.024898995,
0.008061777,
-0.012198393,
0.007870144,
-0.049850855,
0.03861723,
-0.024383571,
0.0036410156,
-0.008418609,
0.00065584533,
-0.000490645,
0.0032825307,
-0.018277766,
-0.013982557,
0.005329363,
0.0040077604,
-0.024277842,
0.0095221475,
-0.005293019,
-0.016718274,
0.027621496,
0.0066410536,
0.015713856,
0.034916744,
0.0100970445,
0.0068326863,
-0.0068987664,
-0.008326097,
0.020273386,
0.01460371,
-0.016890083,
0.00031450015,
-0.00021909695,
0.0065452377,
-0.02585055,
-0.010665334,
0.006700526,
0.0052137226,
-0.01736586,
-0.009158707,
0.03613262,
-0.026101654,
-0.0017692957,
-0.014167582,
-0.016824003,
0.052335467,
-0.02651135,
-0.0019708402,
-0.03267002,
-0.0033420029,
0.0060496363,
-0.024912212,
0.027753657,
-0.016493602,
0.006287525,
0.0034923353,
-0.015713856,
-0.0099120205,
0.019282185,
-0.010625686,
0.020180874,
0.005917476,
-0.0251501,
-0.011464904,
0.04128687,
-0.019374697,
-0.012053017,
-0.001495889,
-0.011762264,
-0.014854815,
0.008207153,
-0.010387798,
-0.0071036145,
0.019321833,
-0.035841867,
0.024039954,
-0.007387759,
0.007711552,
0.01570064,
-0.0017924237,
-0.0121917855,
0.010354757,
-0.0012670866,
-0.009264436,
-0.002958738,
-0.0013703369,
0.019784393,
0.025758037,
-0.004830458,
-0.0011217103,
-0.008597026,
0.05193899,
0.0027423257,
-0.023973873,
-0.018608166,
0.004678474,
0.026062006,
-0.00851773,
0.03637051,
-0.029418876,
0.030714048,
-0.0016024433,
-0.013784316,
0.07485558,
-0.0010804102,
-0.027700793,
-0.014326174,
-0.015660992,
-0.025427636,
-0.13913834,
-0.02181966,
-0.009330516,
0.018872486,
0.011484728,
0.014339389,
-0.006465941,
0.0030446423,
-0.007856928,
0.017392293,
-0.038802255,
-0.0074141915,
-0.014101502,
-0.009310692,
-0.0025639094,
0.002378885,
-0.010268853,
-0.010460486,
-0.004430673,
0.021449612,
-0.0069846706,
-0.008028736,
-0.013097083,
-0.0046850815,
0.006601406,
-0.004744554,
-0.026088437,
0.028546618,
-0.015158784,
0.012297513,
-0.024568595,
-0.012852587,
-0.005345883,
-0.010823926,
-0.0230884,
-0.00971378,
-0.013024395,
-0.034282375,
0.020564139,
-0.025943061,
-0.009165315,
0.0011068423,
0.02238795,
0.010130085,
0.025269045,
-0.027700793,
0.026405623,
0.028837372,
0.000109032226,
0.010605862,
-0.020339467,
0.002905874,
-0.05225617,
-0.006740174,
0.007889968,
-0.020920971,
0.002316109,
0.0076322556,
-0.0054912595,
-0.012720427,
-0.0061652767,
-0.0108569665,
-0.02142318,
0.0044901455,
0.01666541,
-0.0051872907,
-0.00851773,
-0.017656613,
0.026775671,
-0.012006761,
0.004450497,
-0.0055639474,
-0.012766683,
0.023339504,
-0.03304007,
-0.008458258,
-0.015053055,
-0.024925428,
0.013500172,
-0.010354757,
0.007400975,
-0.020947404,
0.02345845,
-0.021978253,
0.02458181,
-0.0025919934,
-0.005385531,
0.0093833795,
0.0043117288,
-0.014194014,
-0.012879019,
0.031269122,
-0.021542124,
-0.022401167,
-0.0135728605,
-0.007804064,
-0.005286411,
-0.014061853,
0.0076851198,
0.0055408194,
-0.01936148,
0.022150062,
-0.048476387,
0.02291659,
-0.002355757,
-0.009997925,
0.0152777275,
-0.002433401,
0.02844089,
-0.0018634598,
-0.001424853,
0.03304007,
-0.029762493,
0.03996527,
-0.013097083,
-0.01839671,
-0.03666126,
-0.023035536,
0.014246877,
-0.0034493832,
0.0020534403,
0.0055936836,
-0.008279841,
-0.0020517881,
0.026313111,
0.009456067,
-0.002486265,
-0.008154289,
0.0064725494,
0.026590647,
-0.011729225,
-0.0076520797,
-0.00005067004,
-0.032643586,
-0.026630295,
-0.0123768095,
-0.008372353,
-0.007400975,
-0.030264702,
0.027304312,
0.034176648,
0.030740479,
-0.018885704,
-0.034388103,
0.03385946,
0.018647814,
0.0031949745,
0.0009160359,
-0.026894616,
0.020537706,
0.012892235,
-0.007625648,
0.035445385,
0.013064043,
-0.010592646,
-0.016348226,
-0.013083867,
-0.0011869645,
0.0025886893,
0.0021525605,
0.00004408784,
-0.042000536,
0.0192954,
0.02232187,
0.018092742,
0.014088285,
0.015079487,
-0.018793192,
-0.0075265276,
-0.008663106,
-0.00085078174,
-0.043427866,
-0.010552998,
0.026550999,
-0.0015413192,
-0.0027803218,
-0.0051410347,
-0.0056432434,
-0.02411925,
0.0014025508,
0.0055672517,
0.008867954,
-0.00005833637,
-0.015039839,
-0.022176493,
0.002405317,
0.03216781,
-0.00074835756,
-0.0050187865,
0.03309293,
0.018039877,
0.005319451,
0.026484918,
0.027859386,
0.02098705,
0.027330745,
0.006677398,
0.025691956,
-0.032114945,
-0.0037401358,
-0.007889968,
0.005891044,
0.008015521,
0.0030760304,
0.013546428,
-0.0196258,
-0.0022252486,
0.04583318,
-0.0006546064,
-0.017683044,
-0.008828307,
0.024647892,
0.010989127,
0.025995925,
0.0020798724,
0.01007722,
-0.0041564405,
0.03187706,
0.002382189,
-0.029762493,
-0.009145491,
0.009931845,
0.018502438,
0.015779937,
-0.012489146,
-0.0003921443,
0.024383571,
0.033462983,
0.018608166,
-0.007883361,
0.0006380863,
-0.021965038,
0.0640713,
0.0032792268,
-0.036502667,
-0.015145567,
-0.010942871,
-0.008028736,
0.022956239,
0.019599369,
-0.0074868794,
0.0640713,
0.027000343,
-0.01936148,
0.019929769,
-0.032009218,
0.02166107,
0.0025672133,
0.0070903986,
-0.023960657,
-0.043057818,
0.0172337,
-0.016757922,
0.025057588,
-0.024925428,
-0.002365669,
0.026062006,
-0.010064005,
-0.0098657645,
-0.008610242,
-0.033145797,
-0.0047181216,
-0.030793343,
0.019282185,
0.011055207,
-0.021330668,
-0.0020534403,
0.011755656,
-0.022295438,
-0.0013439048,
-0.016612547,
0.0070903986,
-0.012779898,
-0.024978291,
-0.009370163,
0.018515654,
-0.006105805,
-0.002373929,
-0.010566214,
0.040441044,
0.015290944,
0.021872526,
-0.007242383,
0.0030165582,
-0.04025602,
0.0065485416,
0.004394329,
0.004926274,
0.0021542124,
-0.015132351
] |
IMPORTANCE Understanding the major health problems in the United States and how they are changing over time is critical for informing national health policy. OBJECTIVES To measure the burden of diseases, injuries, and leading risk factors in the United States from 1990 to 2010 and to compare these measurements with those of the 34 countries in the Organisation for Economic Co-operation and Development (OECD) countries. DESIGN We used the systematic analysis of descriptive epidemiology of 291 diseases and injuries, 1160 sequelae of these diseases and injuries, and 67 risk factors or clusters of risk factors from 1990 to 2010 for | [
0.009953235,
-0.008447982,
0.0055170497,
-0.04694797,
0.013282033,
0.015861519,
-0.020291073,
0.023513773,
-0.015636062,
-0.0043433504,
-0.011186615,
0.021338781,
-0.005636409,
0.01624612,
0.006100584,
0.022744568,
0.03901721,
-0.014774023,
0.0071947104,
-0.015105576,
-0.024773676,
0.014614877,
0.009223818,
0.008945313,
-0.013540644,
0.02734653,
0.03174956,
-0.026444705,
0.004790948,
-0.020821558,
-0.008361779,
-0.0017124737,
-0.018699616,
-0.010490352,
-0.023672918,
0.0056563024,
-0.0049268845,
-0.021245947,
0.015331033,
-0.03119255,
-0.0025198064,
0.006969254,
0.017320354,
-0.01617981,
0.012002236,
0.009203925,
0.007930759,
-0.020039093,
-0.010384255,
0.0072079725,
-0.0025396997,
0.030396823,
-0.032996204,
-0.013527382,
0.0061337394,
-0.014919907,
0.000041910433,
0.0057391906,
0.011485012,
-0.027240435,
-0.01016543,
0.0026706632,
-0.029468473,
0.0012342078,
-0.02505218,
0.0023606608,
-0.02412383,
0.0034415252,
0.012055284,
0.014614877,
0.02461453,
0.0432611,
0.0044991807,
0.0098604,
0.019548394,
-0.0027137653,
-0.025675502,
-0.0036603503,
0.018553732,
0.009727779,
0.014270062,
-0.008759643,
-0.015052528,
-0.0067371666,
0.0111203035,
0.005202074,
0.0035177823,
0.029680667,
0.0014580064,
-0.013872198,
-0.0011156774,
-0.00195285,
-0.0003236791,
0.014628139,
-0.003227673,
0.0052551227,
-0.0041576806,
0.03652393,
0.0032160687,
-0.017691694,
-0.017413188,
0.0036835591,
-0.019919733,
-0.005195443,
-0.014057867,
-0.0033238237,
-0.0013137807,
-0.012320527,
0.0021998573,
-0.02933585,
-0.021670336,
0.01104073,
-0.0035874087,
-0.017307092,
0.0046284865,
-0.0013991557,
-0.012227693,
0.012221062,
0.009767566,
-0.014707712,
0.02232018,
0.015516703,
0.014588353,
-0.020675674,
0.00464838,
-0.018208917,
-0.03360626,
0.0048207873,
0.006249783,
-0.019177053,
-0.020171713,
-0.008076643,
0.014946431,
0.0001901252,
-0.0156228,
0.004489234,
-0.0076588853,
0.013965032,
-0.02405752,
-0.016140023,
-0.0048572584,
0.020184975,
-0.015503441,
-0.021617286,
0.008706594,
0.046046145,
0.037293136,
0.03352669,
0.016763344,
0.0024070782,
0.0010676022,
-0.0074665844,
0.033765405,
0.01872614,
-0.008428089,
-0.0096681,
0.0064453995,
0.03379193,
0.009588527,
-0.0152381975,
-0.00824242,
-0.016086975,
0.005686142,
-0.000940783,
-0.028964512,
0.012923955,
0.01859352,
-0.0048572584,
0.0079970695,
0.014787286,
-0.010861692,
0.03893764,
-0.013872198,
0.01909748,
0.026312085,
0.012851013,
-0.011020837,
0.027293483,
-0.046364438,
-0.019362723,
-0.009230449,
0.015317771,
0.045170847,
0.012744916,
-0.01575542,
0.017996723,
0.036470883,
0.008421458,
0.0008935366,
0.0049898797,
0.02039717,
0.005056191,
-0.00032823795,
-0.0030552654,
-0.6578021,
0.0011853037,
0.013295295,
-0.0026690054,
-0.006637701,
0.011796673,
0.009973128,
0.010676022,
-0.0015019373,
0.032757483,
-0.004790948,
0.015702372,
0.013965032,
-0.028964512,
-0.012128226,
-0.0008102338,
-0.010430672,
-0.019296413,
-0.0027883647,
-0.003477996,
-0.010523507,
0.033394065,
-0.009767566,
0.014999479,
-0.0080037005,
0.035940398,
0.011020837,
-0.027930064,
0.026617114,
0.011677314,
0.0014157334,
0.0040946854,
-0.008872371,
0.027611773,
0.045727856,
-0.015357557,
-0.010410779,
0.02225387,
0.040953487,
0.014415945,
-0.006471924,
-0.020821558,
0.014362897,
0.0032177265,
-0.008447982,
0.013567168,
0.012519459,
-0.003149758,
0.02095418,
-0.0105964495,
0.010821906,
0.0016619118,
-0.007148293,
-0.017943675,
0.010172061,
-0.016670508,
-0.0012300634,
-0.027240435,
0.021033753,
-0.024574744,
-0.012002236,
0.008070012,
-0.029097132,
-0.0117171,
-0.027240435,
0.010172061,
-0.012977003,
0.025900958,
-0.0046583265,
-0.015848257,
0.016590936,
0.03702789,
-0.013792625,
0.005401006,
0.042810187,
0.018805712,
0.04116568,
-0.009654838,
-0.033261444,
0.0015160283,
0.014362897,
-0.0017224203,
-0.013467702,
-0.00023892573,
-0.0012855986,
-0.009760935,
-0.018063033,
0.01481381,
0.014548566,
-0.0017191048,
0.011153459,
-0.003938855,
-0.020383907,
-0.029070608,
-0.000039346072,
0.009535478,
0.0032508818,
0.0026325346,
0.018527208,
0.0043367194,
-0.013315188,
0.014681188,
0.005921545,
0.022771092,
0.008394934,
0.029150182,
-0.011431964,
0.02002583,
0.04644401,
-0.018566994,
0.0022147773,
-0.01104073,
-0.01338813,
0.013288664,
0.010709178,
-0.033022728,
0.0058021857,
-0.0017870732,
0.002508202,
0.01680313,
0.023314841,
0.0116441585,
0.010802012,
-0.050873566,
-0.006040904,
0.029972434,
0.0036537193,
-0.00043930835,
-0.0018368063,
-0.025264375,
0.023593346,
-0.018195655,
0.010012915,
-0.009004992,
0.012227693,
-0.0028248357,
0.002330821,
-0.019946257,
-0.018009985,
-0.03235962,
0.00012505782,
-0.019627966,
0.015105576,
-0.026272297,
-0.036789175,
-0.018328276,
0.012168013,
0.0010932976,
0.01587478,
-0.001468782,
-0.008666808,
-0.043844633,
-0.035569057,
0.0017787844,
0.003756501,
0.0016345587,
-0.00071325444,
0.000063150575,
-0.0065879677,
0.005749137,
0.005530312,
0.007910866,
-0.029362377,
-0.0017041849,
0.01066276,
-0.008209264,
-0.018434374,
0.0234342,
0.0032226997,
-0.02598053,
0.0008661835,
0.0025910905,
-0.018752664,
0.007698672,
0.009462536,
0.029574571,
-0.011246294,
-0.013089731,
0.0008359292,
-0.023102647,
0.013354974,
-0.0062962007,
-0.01872614,
-0.0027137653,
0.026988452,
-0.010304682,
0.013156042,
-0.0072809146,
0.006763691,
0.025396997,
-0.0040184283,
0.014614877,
-0.014893382,
0.0040084817,
0.006485186,
0.009356439,
-0.016153285,
0.001838464,
0.016272645,
0.014575091,
0.04196141,
-0.013832411,
0.006740482,
0.0009855427,
0.020503268,
-0.0014903329,
-0.008587235,
-0.0023822119,
0.0021766485,
-0.0024203404,
0.015357557,
-0.017850839,
-0.00936307,
-0.0020987336,
-0.020967443,
0.012618925,
0.002302639,
0.0019114058,
-0.024349287,
-0.008607129,
-0.0066808024,
-0.017519286,
0.03615259,
-0.01196908,
-0.00651171,
-0.007738458,
-0.01617981,
0.010888216,
0.018235441,
-0.011385546,
-0.023924898,
-0.0045058117,
-0.0055104187,
0.0048506274,
0.0015566436,
0.0028099157,
-0.008640284,
-0.01680313,
0.009263604,
0.007274283,
-0.0005188812,
-0.0030602387,
0.018129345,
-0.0068896813,
0.0026408234,
-0.03389803,
0.03644436,
0.006047535,
-0.007950652,
0.019919733,
-0.01537082,
-0.0058088168,
-0.0147342365,
-0.000570272,
-0.011949187,
-0.03365931,
0.003670297,
0.020184975,
0.02758525,
0.022267131,
0.025503093,
0.0017704956,
0.010642867,
0.008945313,
0.00034150007,
0.00032844517,
-0.0152249355,
-0.025582666,
-0.016922489,
0.0070289336,
-0.025423521,
-0.0034150009,
0.0066310694,
-0.016259383,
0.019442296,
0.014999479,
0.0024336025,
-0.011047362,
0.02547657,
0.017147945,
-0.028221833,
-0.0026955297,
-0.01041741,
0.019627966,
-0.002229697,
-0.018460898,
0.021802956,
-0.0006063284,
-0.02466758,
0.023977948,
0.019734062,
0.006206681,
-0.016100237,
0.0043300884,
0.0031166028,
0.012857644,
0.031112978,
-0.011299343,
-0.01091474,
0.0017771267,
0.009993021,
-0.0248002,
-0.008753012,
-0.013109624,
0.012221062,
0.028725794,
-0.01828849,
0.007340594,
-0.00973441,
-0.00942275,
-0.0018069665,
-0.02132552,
-0.030237677,
0.008786167,
0.0026772944,
0.022147773,
0.0023142432,
-0.012519459,
0.022532374,
-0.0012027102,
-0.00047992365,
-0.041139156,
-0.009648207,
-0.0072013414,
0.0736314,
0.017890627,
-0.0012657054,
0.020715462,
-0.00533138,
-0.0063824044,
0.026511015,
-0.034428515,
0.027505677,
0.015331033,
0.00483405,
0.0017008693,
0.02194884,
0.008600498,
0.00042853286,
0.010331206,
0.013156042,
-0.016471576,
0.01358043,
0.004655011,
-0.024137093,
-0.006803477,
0.041245252,
0.041934885,
0.01078875,
-0.015410606,
0.015781946,
0.036603503,
-0.004290302,
0.009303391,
-0.024588006,
0.020370645,
-0.014946431,
0.02976024,
-0.019243363,
0.026205987,
0.023394413,
0.0047776857,
0.008176109,
-0.0041079475,
0.03379193,
0.0048506274,
-0.00090182543,
0.006578021,
0.013341712,
0.005543574,
0.00051142124,
0.011896139,
0.012300634,
-0.011955818,
0.027373055,
-0.025038918,
-0.012181275,
-0.026961928,
0.022585424,
-0.0069162054,
0.0061602634,
-0.018142607,
-0.029282803,
-0.019137267,
-0.020688936,
-0.010616343,
0.021789694,
-0.018898549,
-0.0126454495,
-0.0071880794,
-0.030105056,
0.01661746,
-0.029441949,
-0.008461244,
0.016219595,
-0.036099542,
-0.0049898797,
0.012015498,
0.010344468,
0.006263045,
0.02250585,
-0.012910692,
0.00843472,
-0.00065606146,
-0.015052528,
-0.006276307,
-0.0014571776,
-0.022187559,
-0.0040151128,
0.0036835591,
-0.011186615,
-0.024468647,
0.0022064885,
0.03249224,
0.0045290203,
-0.010099119,
0.012360314,
0.010258265,
-0.004369875,
0.009535478,
0.00948906,
0.019482082,
-0.014986217,
-0.02640492,
-0.0022926922,
-0.0035940397,
-0.011538061,
-0.01810282,
0.0026259036,
-0.0080037005,
-0.004098001,
0.0016934094,
0.011922663,
-0.03917636,
0.033181872,
-0.03055597,
0.024760414,
-0.008076643,
0.019866684,
0.0047146906,
0.005215336,
0.014270062,
0.017055111,
-0.005338011,
-0.013527382,
-0.0045787534,
0.007711934,
0.005500472,
-0.036603503,
0.012121595,
-0.01488012,
-0.020874606,
-0.0339776,
-0.012824489,
-0.002402105,
0.023235267,
-0.0048439964,
-0.029998958,
0.0018799083,
-0.00085043465,
-0.016020665,
0.015529965,
-0.006249783,
-0.021935578,
-0.002950826,
-0.016338956,
-0.009469167,
-0.021365305,
0.054905254,
-0.036470883,
-0.004383137,
-0.004701428,
-0.024203405,
0.017452976,
0.0038891223,
-0.006150317,
-0.020688936,
-0.0071681864,
-0.017519286,
-0.00973441,
-0.015888043,
0.0055037877,
0.031563893,
0.023832064,
0.02151119,
-0.012473042,
-0.0061602634,
0.018129345,
0.004396399,
0.011690576,
-0.005228598,
-0.01946882,
-0.0048307343,
0.0065813367,
0.010324575,
0.0024999133,
-0.035436437,
-0.00654155,
-0.0032061222,
-0.020781772,
-0.0034746805,
-0.013467702,
-0.03718704,
-0.023712704,
-0.0036802436,
0.007844555,
-0.0151321,
0.025967268,
-0.06349912,
-0.0036039862,
0.016789868,
-0.008036857,
0.0015989166,
-0.024442123,
0.007532895,
0.00588839,
0.02176317,
0.0058287103,
-0.018925073,
-0.008965206,
-0.018063033,
-0.03259834,
0.0103511,
0.00025073733,
0.0063293558,
0.01580847,
-0.0039587487,
-0.027213909,
-0.0030403454,
0.016166547,
-0.012280741,
-0.0029126974,
0.003491258,
-0.015503441,
-0.003477996,
-0.012691868,
0.00050810573,
-0.012851013,
0.011179984,
0.009270235,
-0.01413744,
0.017877363,
-0.015609538,
-0.019760588,
-0.012817858,
-0.018633306,
-0.0016876073,
-0.017399926,
0.03347364,
0.0012358656,
-0.013474333,
-0.0368157,
0.011007575,
0.0013850647,
0.0024617845,
0.019787112,
-0.005347958,
-0.018765926,
-0.005755768,
0.009767566,
-0.00072154327,
-0.018248703,
-0.03421632,
0.030927308,
0.0116242645,
-0.0068697883,
-0.004141103,
-0.009595158,
-0.008341885,
0.016033927,
0.0037996029,
-0.00041609962,
0.010755595,
-0.044560786,
0.0067603756,
0.010828537,
-0.048008945,
0.029309327,
-0.0019064324,
-0.02473389,
0.007247759,
-0.04761108,
-0.0046085934,
0.006256414,
-0.014946431,
-0.00830873,
-0.0048572584,
-0.0065879677,
0.0045389673,
-0.0009681362,
-0.0068896813,
0.01338813,
-0.008666808,
0.0338715,
-0.020529792,
-0.02058284,
0.018169131,
-0.00461854,
-0.011504905,
0.018832238,
-0.02827488,
-0.013049945,
-0.0141904885,
-0.0039653797,
0.014800548,
-0.008050119,
-0.022346705,
-0.0024468647,
-0.0075063705,
-0.0069095744,
-0.016670508,
-0.013461071,
0.012439886,
-0.0050296662,
-0.016007401,
0.016856179,
0.0018252019,
0.028619695,
0.0073207007,
-0.010768857,
-0.0005396033,
0.0058353413,
-0.022107987,
0.0032028067,
0.008375041,
0.016060451,
0.0006457004,
0.01104073,
-0.037664477,
-0.011896139,
0.019986043,
0.008925419,
-0.024574744,
-0.029654143,
0.010384255,
0.013335081,
0.0020622627,
-0.0042604622,
0.022837404,
0.012817858,
0.0054275305,
-0.03631174,
-0.028380977,
0.028593171,
-0.007420167,
0.014323111,
0.012930586,
-0.011014206,
0.030582493,
-0.01506579,
0.018779188,
0.0095553715,
-0.007519633,
-0.02300981,
-0.027823968,
0.0312456,
-0.027505677,
0.021935578,
-0.021988627,
-0.0027021607,
0.0018765926,
0.01710816,
0.010556662,
-0.008812691,
0.0016254409,
-0.02511849,
0.00010920543,
-0.0023888429,
0.000080246304,
-0.024402335,
0.007837924,
0.0131427795,
-0.03800929,
-0.0058353413,
-0.01295711,
0.034269366,
0.008361779,
0.0076190988,
-0.03403065,
-0.009144245,
-0.038858067,
0.0026325346,
0.007075351,
0.010251634,
0.03440199,
0.02994591,
0.01680313,
0.019760588,
-0.0047710547,
0.018235441,
-0.0432611,
-0.018328276,
0.027558725,
0.0023142432,
0.0152381975,
0.013447809,
-0.024150355,
0.008149585,
0.012499566,
0.0030917362,
-0.015901305,
0.018301751,
-0.0016445053,
-0.01828849,
-0.012545983,
-0.0020191607,
-0.0031232338,
0.009840507,
-0.0073008076,
-0.023885112,
-0.0039786417,
-0.007864448,
0.009396225,
-0.003855967,
-0.012307265,
0.0020092141,
-0.012075177,
-0.0007940706,
-0.009741041,
-0.002417025,
0.006263045,
-0.010026177,
0.007247759,
0.010463828,
0.0034150009,
0.024641054,
0.007698672,
-0.010981051,
-0.013063207,
0.007519633,
-0.003962064,
-0.009993021,
-0.01617981,
-0.003700137,
0.0006784413,
-0.017413188,
-0.0130831,
-0.024044259,
-0.009124352,
-0.026617114,
-0.02132552,
-0.019137267,
0.0105964495,
0.011770149,
-0.0100659635,
0.000574002,
0.0070024095,
-0.03286358,
0.0033271392,
-0.032837056,
0.020887868,
-0.051112283,
-0.0020009251,
0.012075177,
-0.008905526,
0.022598686,
0.010019546,
0.0005594965,
-0.020476744,
0.019627966,
0.20848082,
-0.00868007,
0.0084944,
0.02808921,
0.00694273,
0.01147175,
0.007055458,
-0.00960842,
-0.009654838,
0.02250585,
0.0035807777,
0.014031343,
0.0067040115,
0.01016543,
-0.0014903329,
-0.0090713035,
-0.04469341,
0.01320246,
-0.004986564,
0.020848082,
-0.0070156716,
-0.009416119,
-0.01184309,
-0.008282206,
0.02412383,
0.018089557,
-0.020781772,
0.018646568,
0.025927482,
-0.016498102,
-0.012996896,
-0.023182219,
0.0030038746,
0.025065443,
-0.021007229,
-0.0013054918,
-0.0061768414,
-0.027744396,
0.015331033,
-0.003050292,
0.021153111,
0.0116507895,
0.010099119,
-0.020874606,
0.034242842,
0.025065443,
0.003235962,
-0.007725196,
-0.01351412,
0.018673092,
-0.029919386,
-0.013215722,
-0.0036305105,
0.00039641364,
0.0022529059,
-0.011226401,
0.03416327,
-0.003713399,
-0.0040117973,
0.008129692,
0.0019445611,
0.006747113,
-0.02758525,
-0.0026971875,
-0.014283324,
0.020728724,
-0.0019395879,
-0.012970372,
-0.0015276327,
-0.029866338,
0.015211673,
0.008335254,
-0.012824489,
0.00248002,
-0.007559419,
-0.016060451,
0.016511364,
0.014349635,
0.008036857,
0.021365305,
-0.01686944,
-0.02976024,
-0.014787286,
0.0057060355,
-0.002607668,
-0.011034099,
0.029707192,
0.011856352,
-0.017452976,
0.0026905565,
-0.010530138,
0.0031331803,
-0.025277637,
0.0035642,
-0.0038725447,
0.0080302255,
-0.008600498,
0.0070223026,
0.003050292,
-0.023447461,
-0.02243954,
0.0754881,
-0.00069253234,
-0.0174795,
-0.0023042967,
-0.0207022,
-0.028991036,
0.012565877,
0.027664822,
-0.0035907242,
0.0013618559,
-0.0010999286,
0.010390886,
-0.015516703,
0.019349461,
0.014575091,
0.01104073,
-0.015529965,
-0.005464001,
-0.030821212,
-0.006796846,
-0.031563893,
0.0100792255,
0.023288317,
-0.013136148,
-0.0015956011,
-0.004495865,
-0.007559419,
0.0047776857,
-0.042253174,
-0.001503595,
-0.035409912,
0.007420167,
-0.008229157,
-0.0045190738,
-0.006614492,
-0.0034547872,
0.0030353721,
-0.019561656,
0.007917497,
-0.022333443,
-0.024932822,
0.012486304,
-0.0037233455,
0.010901478,
-0.016670508,
0.0033652678,
-0.00861376,
0.0076124677,
-0.0070421956,
-0.029362377,
-0.002801627,
-0.012008867,
-0.01648484,
0.022731306,
-0.005238545,
-0.0025811438,
-0.02269152,
0.01761212,
0.0055933073,
-0.023473985,
0.011783411,
0.028434027,
0.0024783623,
0.0031182605,
0.015596275,
-0.1690127,
0.02125921,
0.01506579,
-0.025675502,
0.01668377,
0.00020618482,
0.02387185,
-0.00016401536,
0.0031945177,
-0.010729071,
0.03838063,
0.009223818,
-0.037717525,
-0.013766101,
-0.007698672,
-0.0030237676,
-0.015516703,
0.026418181,
0.011988974,
0.012201168,
0.031988278,
0.0010783777,
0.010390886,
-0.009290128,
-0.0016685429,
0.041324824,
-0.0015790234,
0.030847736,
-0.013341712,
-0.017094897,
-0.015609538,
0.0056397244,
0.02368618,
0.0036802436,
-0.03861935,
0.0096681,
-0.00011065597,
-0.019296413,
-0.006471924,
0.010344468,
0.024455385,
0.026007054,
0.0057889237,
0.014429207,
0.011995605,
0.02869927,
0.010735702,
-0.033765405,
0.020039093,
-0.010092488,
-0.0005744164,
-0.0039521176,
0.011816566,
0.0062962007,
0.0073671183,
0.0043798215,
-0.011836459,
-0.0011985658,
0.014495518,
-0.007731827,
-0.026298821,
-0.020741986,
0.0010319602,
0.007539526,
-0.01295711,
-0.011564585,
-0.030609017,
0.009939973,
-0.029733716,
0.0026756367,
-0.022956762,
-0.0058419723,
-0.00923708,
-0.017055111,
0.02454822,
0.012247586,
0.010331206,
-0.0024435492,
0.00061917613,
-0.02058284,
-0.0015234882,
0.005908283,
-0.013845673,
-0.002929275,
0.007930759,
0.006312778,
-0.0066874335,
0.019322937,
0.0028977774,
-0.024349287,
0.008196002,
-0.024110569,
0.008136323,
-0.017506024,
-0.0031530736,
0.037425756,
0.005507103,
-0.0053512733,
0.0054043215,
0.0029077241,
0.0018500685,
0.015848257,
-0.024999132,
0.023460723,
0.0041311565,
-0.010152168,
0.0065514967,
-0.012599032,
0.03188218,
-0.0044428166,
-0.024375811,
0.008693332,
-0.002614299,
0.008759643,
-0.0033039304,
0.008819322,
-0.0077517205,
0.02281088,
-0.005609885,
-0.008428089,
0.041139156,
-0.007930759,
-0.023765754,
0.020105403,
0.00075096864,
-0.03050292,
-0.11193246,
-0.005603254,
0.005023035,
-0.005139079,
0.02448191,
0.02095418,
-0.007135031,
0.0037598165,
0.0008210093,
0.031272124,
-0.007227866,
-0.01388546,
-0.00086701236,
-0.016604198,
0.03129865,
-0.018646568,
-0.011504905,
-0.036046494,
-0.0072079725,
0.038327582,
0.0080169635,
-0.021405093,
0.010483721,
-0.015848257,
-0.018381326,
-0.008487769,
-0.025330685,
0.0073207007,
-0.015026004,
0.008076643,
-0.013434547,
0.00031124582,
0.009979759,
-0.010689284,
-0.018275227,
0.0031895444,
-0.0016726872,
0.0008110627,
0.02795659,
-0.02795659,
0.01722752,
-0.0071615553,
0.02380554,
-0.013752839,
0.0065382347,
-0.027452627,
-0.011173353,
-0.0033520057,
-0.007513002,
0.009515584,
0.0047776857,
-0.011133566,
-0.014933169,
-0.032094378,
-0.0121481195,
-0.0065747052,
-0.008408196,
-0.019322937,
-0.017028587,
0.011451857,
-0.00008278476,
0.006458662,
-0.034985524,
0.023235267,
0.021418355,
-0.022824142,
-0.023089385,
0.0009921738,
0.0005296567,
-0.029733716,
-0.024137093,
0.026272297,
-0.016458314,
0.0064387685,
-0.022452801,
0.021298995,
-0.007247759,
0.009084566,
0.022413015,
-0.010642867,
-0.012612294,
-0.01283112,
-0.0032658018,
-0.003713399,
0.020755248,
0.016259383,
-0.01184309,
-0.010125644,
-0.0048075253,
-0.0044991807,
0.022744568,
0.0421736,
0.022824142,
0.0030105056,
0.024004472,
0.029521521,
0.0069228364,
-0.009316653,
0.0016867783,
0.010874954,
-0.01580847,
0.011511536,
-0.05201411,
0.02790354,
0.013063207,
-0.009303391,
-0.0039521176,
0.008096536,
0.00744006,
-0.013726314,
0.013792625,
0.04416292,
-0.0010228425,
0.023288317,
-0.018063033,
0.0019031169,
-0.03440199,
-0.028858414,
0.025821384,
0.037001368,
0.021962103,
0.031908706,
-0.00013821636,
0.0100659635,
0.027850492,
0.040210806,
-0.008819322,
0.0076787784,
0.0038161806,
0.015980877,
-0.006093953,
-0.023885112,
0.005580045,
-0.017850839,
0.005231914,
-0.007844555,
-0.004300249,
-0.025755074,
0.011425333,
0.01754581,
0.041192204,
0.049494304,
0.0026540856,
-0.028036162,
-0.0071085067,
-0.03819496,
-0.014906645,
0.006040904,
-0.023699442,
0.0054540546,
-0.011266187,
-0.009601789,
0.021564238,
-0.00283644,
-0.009004992,
-0.02697519,
-0.0004575438,
0.007062089,
0.012837751,
0.031908706,
0.00095736067,
-0.036364786,
0.035913873,
0.011856352,
0.013341712,
0.010404148,
0.0151321,
-0.0064818705,
-0.008341885,
0.0037366077,
0.0024203404,
-0.025078705,
-0.011849721,
0.021789694,
-0.014389421,
0.023182219,
0.0019578233,
-0.0024700735,
-0.0034050543,
0.014601615,
-0.005338011,
0.01506579,
0.02584791,
0.018646568,
-0.014853596,
0.03644436,
0.014747499,
0.004873836,
-0.011975711,
0.013766101,
-0.007711934,
0.0012358656,
-0.03188218,
0.024455385,
0.0052816467,
0.017373402,
0.0100593325,
0.010390886,
0.0071085067,
-0.0025844593,
0.0312456,
0.01722752,
-0.004054899,
0.0061901035,
-0.0074732155,
-0.025675502,
-0.01202876,
-0.0049136225,
-0.008169478,
-0.010298051,
-0.027134337,
0.041006535,
0.004041637,
0.035781253,
-0.0062962007,
-0.013461071,
-0.014362897,
0.0044693407,
-0.012625556,
-0.008746381,
-0.004141103,
0.023580084,
0.0131825665,
0.01202876,
-0.017187733,
-0.027373055,
0.028937988,
0.010483721,
0.0302642,
-0.007426798,
0.011657421,
-0.002587775,
0.0038758602,
0.0016561096,
-0.008103167,
-0.009641575,
0.01413744,
-0.03074164,
0.022744568,
0.0121547505,
0.014840334,
0.056284517,
0.009508953,
0.0016710295,
0.007698672,
0.01952187,
0.022996549,
0.011664052,
0.015781946,
-0.012114964,
-0.013248877,
0.02777092,
-0.0015707347,
-0.012373576,
-0.03601997,
-0.016829655,
0.0178641,
0.0065083946,
0.017002063,
0.008096536,
-0.00026275613,
0.021935578,
-0.011339129,
0.015357557,
-0.008169478,
-0.020224763,
-0.01078875,
0.003398423,
-0.0116043715,
-0.008156216,
-0.031855658,
-0.008693332,
0.0042670933,
-0.003577462,
0.00886574,
0.031404745,
0.0026888987,
-0.010881585,
-0.017041849,
0.007539526,
0.00412121,
0.010397517,
0.017028587,
-0.0136865275,
-0.0076323613,
-0.048751622,
0.013726314,
-0.013248877,
-0.019150529,
-0.025648978
] |
An observational prospective cohort study assessed malaria risk perception, knowledge and prophylaxis practices among individuals of African ethnicity living in Paris and travelling to their country of origin to visit friends or relatives (VFR). The study compared two groups of VFR who had visited a travel clinic (TC; n=122) or a travel agency (TA; n=69) before departure. Of the 47% of VFR citing malaria as a health concern, 75% knew that malaria is mosquito-borne and that bed nets are an effective preventive measure. Perception of high malaria risk was greater in the TA group (33%) than in the TC | [
0.012280496,
-0.009179095,
0.023823503,
-0.04266896,
0.0060414774,
0.030316034,
-0.019991199,
-0.01288629,
-0.013307712,
-0.028472314,
-0.00939639,
0.008184803,
0.0029153833,
-0.0065419157,
0.011806397,
0.003417468,
0.04040382,
-0.021479346,
0.008546962,
-0.015210695,
-0.020452129,
0.037085123,
-0.0110689085,
-0.0024988998,
0.006597886,
0.007756796,
0.015474084,
-0.028735703,
-0.0111610945,
-0.0034207602,
0.02437662,
-0.009600516,
-0.0045829625,
-0.011753719,
-0.02905177,
-0.019885844,
0.011431068,
-0.02394203,
0.017449498,
0.0050406004,
0.0035820857,
0.009989015,
-0.0110228155,
0.011286204,
0.009383221,
0.0155531,
0.02645739,
0.0068612746,
-0.033186972,
0.042168524,
0.019780489,
0.0061698793,
-0.023889352,
0.0040660626,
-0.02556187,
-0.009133002,
-0.009778304,
0.005834059,
0.0039574145,
-0.04435465,
-0.008388929,
0.01623791,
-0.0361896,
0.001149033,
-0.0022355113,
0.015158017,
0.0056562712,
0.01833185,
0.008928875,
0.01031825,
0.026562747,
0.031527624,
0.011668118,
-0.005162418,
0.034951676,
0.0032314495,
-0.021255465,
0.0072168494,
-0.005787966,
0.010166802,
0.0039179064,
0.0028873982,
-0.033977136,
0.02092623,
0.01079235,
0.004964876,
0.0043788366,
0.026035968,
0.0022470346,
0.0048496434,
-0.0074012214,
0.024719026,
-0.0152238645,
0.007960922,
0.029789258,
-0.0003360263,
-0.00047944966,
0.018634748,
0.0044545606,
-0.006048062,
-0.028577669,
0.009429314,
-0.015671626,
-0.012142217,
-0.01033142,
0.009778304,
0.003796089,
0.0045467466,
0.012622901,
-0.048437174,
-0.011694456,
0.029130785,
0.0010453238,
-0.03345036,
-0.023533776,
-0.008843274,
-0.014236157,
-0.015342389,
0.004503946,
-0.008540377,
0.024350282,
0.021913936,
0.0075329156,
0.001379498,
0.012557054,
-0.0077041183,
-0.016395943,
-0.012668994,
-0.0057287035,
-0.008342836,
0.00017408344,
0.010377513,
0.01393326,
-0.01971464,
-0.01369621,
0.025930613,
-0.032423142,
-0.009435899,
-0.035346758,
0.0018865212,
0.00086835946,
0.011714211,
-0.008388929,
-0.011780058,
0.006074401,
0.030105324,
0.019819997,
0.020649672,
0.0013383436,
-0.012748011,
0.0035392852,
-0.022532899,
0.008672072,
0.0055344542,
0.0018963984,
-0.007908245,
-0.011733965,
0.02436345,
-0.03316063,
-0.01066724,
-0.009765134,
0.0025071308,
0.0057122414,
0.015592609,
-0.0054620225,
0.017699718,
0.0037434113,
-0.0030207387,
0.014657578,
-0.0090474,
-0.003124448,
0.025430175,
-0.010963553,
0.018516222,
0.007249773,
0.01835819,
-0.010133878,
-0.012161971,
-0.020359943,
-0.015921844,
-0.041246664,
0.033582054,
0.0339508,
-0.0078753205,
-0.009534669,
0.0027886275,
0.016856873,
0.0012198187,
-0.000633779,
-0.009218603,
0.01323528,
0.009007892,
0.017765565,
-0.020188741,
-0.6671108,
-0.017054416,
0.0059855073,
0.015263373,
0.009126417,
-0.002390252,
0.031079862,
0.009956092,
-0.032449484,
0.04132568,
0.0009300912,
0.010449945,
0.0055805473,
-0.04461804,
-0.0071839257,
-0.01947759,
-0.001433822,
0.0005856282,
0.021782242,
-0.013748888,
-0.024495145,
0.025469683,
0.0048035504,
0.009844151,
-0.021400329,
0.014328343,
0.011641779,
-0.026114985,
-0.004852936,
0.024060555,
-0.019846335,
0.041299343,
0.004026554,
0.013169433,
0.04295869,
-0.03273921,
0.015882336,
0.022835797,
0.0112664495,
0.031922705,
-0.012385852,
-0.0073024505,
0.028024552,
0.0042800657,
-0.0014478145,
0.016461791,
0.006008554,
0.00042965275,
0.00042430268,
0.008441607,
0.0008210318,
0.0013424591,
-0.03834939,
-0.00038808672,
0.009896829,
-0.0023507439,
0.013722549,
-0.020531146,
0.010509208,
0.008632563,
-0.02508777,
0.00040002153,
0.0126426555,
-0.0075790086,
-0.0076711946,
0.0031030476,
0.003684149,
0.011918337,
0.006406929,
-0.0366637,
0.00073584204,
0.042879675,
-0.030316034,
-0.005610178,
0.013762058,
0.03297626,
0.014697087,
-0.003280835,
-0.0357155,
-0.0086391475,
-0.0115035,
0.0024758533,
-0.0154082365,
0.0068151816,
0.015118509,
-0.017541684,
-0.011661533,
0.0064892382,
0.0030684778,
-0.009666364,
-0.011898583,
0.015500423,
-0.0008724749,
-0.00017706714,
-0.010028523,
0.014618071,
-0.0007988084,
-0.018226495,
0.011536423,
-0.015184356,
-0.018845458,
-0.036532007,
0.013169433,
-0.03671638,
0.004882567,
-0.013044323,
-0.020768195,
0.0047837966,
0.033819105,
-0.004201049,
-0.0073946365,
-0.00464881,
0.006499115,
-0.016843705,
0.039587315,
-0.022664594,
0.0165013,
0.0016766334,
0.007157587,
-0.04132568,
-0.0021795412,
0.0146444095,
0.024692686,
-0.019675132,
0.012293666,
0.00316231,
-0.0032380342,
-0.012497792,
0.007710703,
-0.007881906,
0.008810351,
0.027287064,
0.014025446,
-0.012399021,
0.022598747,
-0.020109724,
0.023533776,
0.007822643,
0.009653194,
-0.0334767,
-0.013985937,
-0.020373113,
-0.0012568578,
0.0017383652,
0.0012288727,
-0.037269495,
-0.0030404928,
0.0009901767,
-0.019819997,
-0.004125325,
0.014262496,
-0.015171187,
-0.004918783,
-0.012036862,
0.007690949,
0.0033335127,
0.010805519,
-0.035136048,
-0.032581177,
0.0016889798,
0.031738333,
-0.002197649,
0.002785335,
-0.001516131,
0.015395067,
-0.011371805,
0.019148355,
0.019385405,
0.019648794,
-0.025417006,
0.0023672055,
-0.02973658,
0.010779181,
0.04343279,
0.0012642655,
0.028472314,
0.00068316434,
-0.00788849,
-0.022638256,
-0.009936337,
0.0032199263,
-0.013202356,
-0.0012906045,
0.0023392206,
0.030316034,
-0.0138805825,
0.0057122414,
0.012952137,
0.022598747,
0.040983275,
-0.003144202,
0.014683918,
-0.021492515,
0.0153160505,
-0.012794104,
0.00812554,
0.012543885,
0.032897245,
-0.021479346,
0.032818228,
-0.0006592947,
0.010173387,
0.025575038,
-0.0204653,
0.0027458267,
-0.014525885,
0.00038726363,
-0.0021532022,
0.025904274,
0.024956075,
0.020820873,
-0.016856873,
0.0006568255,
-0.02299383,
-0.01185249,
-0.0066275173,
0.0065386235,
-0.00017181995,
-0.021281803,
0.0004732765,
-0.01463124,
-0.006370713,
0.026641762,
0.012965307,
-0.0047179493,
0.00046751488,
0.0060250154,
-0.002242096,
0.010403852,
-0.013261619,
-0.015131678,
0.0090474,
0.0036808564,
0.03389812,
0.02645739,
-0.0029795843,
-0.0028380128,
-0.033028938,
0.020596992,
0.00039384834,
0.021992953,
0.018305512,
0.015342389,
0.0032133416,
0.005847228,
-0.00869841,
0.016000861,
-0.00024713264,
0.001581155,
0.028946413,
0.0071707563,
0.023007,
-0.021887597,
0.016777858,
-0.014183479,
0.004207634,
-0.002031385,
0.0044446834,
0.030026307,
0.030684778,
0.009666364,
0.014315174,
0.0031919412,
-0.0045994245,
-0.0014000754,
-0.003142556,
-0.014275665,
-0.008507454,
-0.0054356833,
0.011760304,
-0.019227372,
-0.023257218,
0.022335358,
0.001028862,
0.011891998,
-0.006008554,
-0.0037895043,
-0.010035108,
0.011589101,
0.009916583,
-0.03408249,
-0.020847213,
0.006397052,
0.010884536,
-0.007111494,
-0.031185217,
-0.0002496019,
0.028498653,
-0.015921844,
0.006413514,
-0.00029157946,
-0.0014436991,
-0.010812105,
-0.020228248,
0.004688318,
-0.005699072,
0.021650547,
-0.012879705,
0.022335358,
0.00858647,
-0.023507439,
-0.006564962,
-0.033134293,
-0.012431945,
0.017844582,
0.012208064,
-0.00621268,
-0.0063443743,
-0.016185233,
0.012688749,
0.018963983,
-0.010344589,
-0.0020708933,
0.013017984,
0.00044693763,
0.0077436264,
-0.02926248,
-0.001470861,
0.0045928396,
-0.025654055,
-0.011108417,
-0.026997337,
-0.010733088,
-0.016172064,
0.07754162,
-0.019793658,
-0.014802443,
0.019819997,
0.018832289,
0.0110294,
-0.012175141,
-0.03134325,
0.0215847,
0.0032512038,
-0.0029022137,
-0.011319128,
0.021031585,
0.016922722,
0.016593486,
0.026891982,
-0.017739225,
-0.010140464,
0.0027968583,
0.01833185,
-0.0022733733,
-0.020241419,
0.027524116,
0.04667247,
0.02344159,
-0.0023869597,
-0.0019704765,
0.0117405495,
0.016145725,
-0.0052677733,
0.019201033,
-0.012352928,
0.003759873,
0.021400329,
0.004164833,
-0.015302881,
-0.015026323,
-0.00975855,
0.0030174463,
-0.010601394,
0.028498653,
0.02413957,
-0.00032367997,
-0.005517992,
0.00893546,
-0.010706749,
0.0022223417,
-0.007289281,
0.0025696857,
-0.00487269,
0.023797166,
0.024086893,
-0.015381898,
-0.0027310112,
0.00021297442,
0.0054455604,
0.013202356,
-0.0013399898,
-0.010673826,
-0.020241419,
-0.03650567,
-0.031685654,
0.015434575,
-0.0029993383,
-0.02997363,
-0.015013154,
0.0046356404,
-0.01485512,
-0.01739682,
-0.033345003,
0.007282696,
-0.028893735,
-0.013564516,
0.00090375234,
0.008500869,
0.00018128548,
0.012741426,
-0.011352051,
0.006377298,
0.0039672917,
-0.02324405,
0.010094371,
0.006647271,
-0.018871797,
-0.0011350405,
0.022585578,
0.019082509,
-0.02020191,
-0.010430191,
-0.01056847,
-0.010970138,
-0.0096334405,
0.0152238645,
-0.00029548915,
-0.0041319095,
0.01115451,
-0.0054488527,
0.023415253,
-0.015079001,
-0.008171633,
0.031027185,
-0.033977136,
0.006515577,
-0.014236157,
0.012675579,
0.0031145709,
-0.013999107,
-0.0049681687,
-0.013373559,
-0.028419636,
0.015131678,
-0.016422283,
-0.00007248332,
0.0110689085,
0.028498653,
0.01901666,
-0.0015836243,
0.0153160505,
0.030632101,
-0.0062291417,
-0.0023836673,
0.0050307233,
0.016646164,
0.012096124,
-0.015961353,
0.012655825,
0.013959599,
-0.013630363,
-0.024692686,
-0.019108847,
0.022717271,
0.042589948,
-0.00023910751,
-0.011233526,
-0.021202788,
-0.027471436,
-0.004991215,
-0.019596117,
-0.015065831,
-0.006288404,
0.0001982617,
-0.008632563,
-0.00777655,
-0.024258096,
0.022137817,
-0.02251973,
-0.0024346989,
-0.0050307233,
-0.0334767,
0.020030707,
-0.0095412545,
-0.0053632515,
-0.01881912,
-0.0033845443,
-0.025285311,
-0.031053523,
-0.0044150525,
-0.018081632,
0.036558345,
0.013426237,
0.017449498,
-0.021150108,
-0.002535116,
-0.0040298463,
-0.0010247465,
-0.0014494607,
-0.0028692903,
0.013604024,
-0.014907798,
0.023533776,
0.010417022,
-0.0041845874,
-0.00022388036,
0.0022091724,
0.013149679,
0.012622901,
-0.018200155,
-0.029841935,
-0.0077172876,
-0.01392009,
-0.002535116,
0.008882782,
-0.0105487155,
0.019938521,
-0.039323926,
-0.0010156925,
0.048410837,
-0.012965307,
0.008158464,
-0.016290588,
0.027023677,
-0.00441176,
-0.0029186755,
-0.03155396,
0.02345476,
-0.015724303,
0.025838427,
-0.006387175,
-0.010449945,
0.027998215,
0.015684795,
-0.010627733,
0.009719041,
0.012497792,
-0.015697964,
0.02575941,
0.0049681687,
-0.009185679,
0.008816935,
-0.010956968,
-0.01673835,
-0.017699718,
-0.0013704441,
-0.011589101,
-0.014539054,
0.005027431,
-0.004566501,
0.019727811,
-0.021347651,
-0.028182587,
-0.011286204,
0.00014115986,
0.035346758,
-0.0016470022,
0.012352928,
0.0045072385,
-0.004688318,
-0.023652302,
-0.0042866506,
0.024258096,
-0.014986815,
0.020188741,
0.016685672,
-0.01902983,
-0.028156247,
0.035346758,
0.026259849,
-0.022796288,
-0.0250746,
0.025575038,
0.0125373,
-0.0009449068,
-0.009844151,
-0.00395083,
-0.036769055,
0.05367861,
0.010028523,
-0.004309697,
0.026207171,
-0.019622454,
-0.01718611,
0.026786627,
-0.02598329,
-0.00093420665,
-0.0069402913,
-0.007473653,
0.013195772,
-0.02208514,
0.009198849,
0.01580332,
0.010627733,
0.023375744,
0.006828351,
-0.001865121,
0.012036862,
0.007144417,
-0.013241865,
0.0145522235,
-0.0027425345,
0.04000874,
0.0018387821,
-0.007572424,
-0.0040298463,
0.0032248648,
0.0034602685,
-0.000051134437,
-0.0050899857,
-0.022532899,
0.0012115878,
-0.020689178,
0.027445098,
0.013722549,
-0.03268653,
-0.005801135,
-0.02575941,
-0.008197972,
-0.004899029,
-0.016198402,
0.008290158,
-0.006397052,
-0.0030289695,
-0.0054620225,
-0.0009358528,
0.017831411,
-0.028577669,
-0.0036643946,
-0.01879278,
0.009679534,
-0.025575038,
0.014249327,
0.027497776,
0.01394643,
-0.02532482,
0.010502622,
-0.016606655,
-0.035873536,
0.01971464,
-0.0035886704,
-0.033819105,
-0.03208074,
0.0019243833,
0.0110689085,
-0.016632995,
-0.029288819,
0.041378357,
0.0011934799,
-0.0019556608,
-0.02320454,
0.000514431,
0.033608392,
-0.016079878,
0.0058505205,
0.01974098,
-0.022203663,
0.012873121,
-0.013709379,
0.011707626,
0.0042866506,
-0.030026307,
0.005652979,
0.0013737364,
0.033503037,
-0.019174695,
-0.009119832,
0.0095873475,
-0.0076316865,
-0.01673835,
0.0066867797,
0.017620701,
-0.014341513,
0.0060809855,
-0.009646609,
-0.014907798,
0.0033598517,
0.0013844366,
0.014302004,
0.014420529,
-0.01954344,
-0.023072846,
0.0071707563,
-0.02370498,
0.042300217,
0.003555747,
-0.0031557253,
-0.00018221146,
-0.022440713,
-0.061369557,
0.01440736,
0.010100955,
0.0117405495,
0.0055147,
-0.0027639347,
0.013511838,
0.0050471853,
0.009613686,
0.016053539,
-0.016856873,
-0.015539931,
0.0046916106,
-0.014828782,
0.020689178,
0.0005757511,
-0.04767335,
-0.007361713,
0.028314281,
-0.008876198,
0.0013506899,
0.007473653,
-0.015487253,
-0.002581209,
-0.010048278,
0.024244925,
-0.013294542,
-0.023112355,
-0.0035261156,
-0.022875305,
-0.007460484,
0.00067781424,
0.0036314712,
0.0068612746,
-0.000864244,
0.0065287463,
0.005287527,
0.02416591,
-0.009343713,
-0.011766888,
0.038533762,
-0.028235264,
0.0024659764,
0.0068612746,
0.015237034,
0.0016873336,
-0.0018321973,
0.0047014877,
-0.003694026,
0.005366544,
-0.0014313527,
-0.0045467466,
0.01068041,
0.022809457,
0.010996477,
0.0065287463,
0.0072102644,
0.0031079862,
0.0024988998,
-0.011668118,
-0.032870904,
-0.010410436,
0.017515346,
0.0048298896,
-0.024982413,
0.018740103,
-0.004606009,
-0.00894863,
-0.020847213,
-0.013577686,
0.01928005,
-0.02855133,
-0.0024017752,
0.013617193,
-0.008421852,
0.03434588,
0.0042240955,
-0.006755919,
-0.017304635,
0.01369621,
0.17046514,
0.024455637,
-0.005099863,
0.022374867,
-0.00940956,
0.028314281,
0.03234413,
0.011529839,
-0.0006177287,
0.011332297,
-0.0010354467,
0.006828351,
-0.00088893675,
0.0059394143,
-0.021084262,
0.0072629424,
-0.033713747,
-0.019793658,
-0.001139979,
0.0032051108,
-0.0057254108,
-0.0074407295,
0.009837566,
-0.006973215,
0.019148355,
0.016422283,
-0.002113694,
-0.014104462,
0.019819997,
-0.00006461253,
-0.0012930736,
-0.02483755,
-0.020544315,
0.01079235,
-0.015184356,
0.009574178,
0.002923614,
0.008092617,
0.002151556,
-0.0012519192,
-0.008744503,
0.026180832,
-0.028050892,
-0.015368728,
-0.00042142186,
0.033713747,
0.010403852,
-0.02274361,
-0.009903413,
-0.018015783,
-0.0325285,
-0.011516669,
-0.00755267,
0.0037993814,
-0.015079001,
-0.0037104876,
0.032212432,
-0.00039981576,
-0.02113694,
0.021281803,
0.0038487667,
0.006647271,
-0.026905151,
0.021176448,
0.0017630578,
0.033186972,
-0.016066708,
0.012056616,
-0.0148419505,
-0.01671201,
0.0028659978,
-0.0083494205,
-0.004879275,
0.0083494205,
-0.0041121556,
-0.019885844,
0.013064077,
-0.0015457622,
0.0133142965,
0.0029334913,
-0.014881459,
-0.0103972675,
-0.002877521,
0.0052249725,
-0.016883213,
-0.030711118,
0.028841058,
0.009468822,
-0.015210695,
-0.0054027596,
0.008099201,
0.0030158001,
-0.028050892,
-0.0064365603,
0.00777655,
0.010364343,
0.013551346,
-0.0057221185,
-0.012510961,
-0.009086909,
-0.03042139,
0.054205384,
-0.0033845443,
0.0064398525,
-0.0041977568,
0.015487253,
-0.005159125,
0.024995584,
-0.003326928,
0.010449945,
0.0028709364,
-0.030026307,
0.002949953,
-0.006775673,
0.0017449498,
0.014446868,
-0.006160002,
-0.012385852,
0.016119385,
-0.0126426555,
0.0029993383,
-0.026891982,
0.016580315,
0.02274361,
-0.021505684,
-0.0077436264,
-0.013854244,
0.012912629,
-0.008942045,
-0.035952553,
0.0110228155,
-0.031474944,
0.002324405,
0.0086852405,
-0.006054647,
-0.0009778304,
0.0017976275,
-0.018845458,
0.017963106,
-0.007157587,
0.016606655,
-0.014578562,
0.028709363,
0.0027013798,
-0.025812088,
-0.012728257,
0.013867413,
0.016435452,
-0.024719026,
0.01312334,
-0.012208064,
-0.030316034,
-0.009198849,
-0.024692686,
0.039824367,
-0.011562762,
0.00023149393,
-0.0057188263,
0.009198849,
-0.0042701885,
-0.021255465,
0.0060875705,
0.029894613,
-0.0057747965,
0.013208942,
0.029420514,
-0.16688305,
0.030684778,
0.016224742,
-0.021255465,
0.029157124,
0.0051755873,
0.022374867,
0.007592178,
-0.024231756,
-0.006693364,
0.018489884,
0.0114047285,
-0.018160649,
-0.009356882,
0.010660656,
0.00089634454,
-0.035188723,
0.010028523,
0.047330942,
0.020057047,
0.03529408,
-0.003325282,
0.0074670683,
-0.017014908,
0.0052677733,
0.017765565,
-0.023994707,
-0.00487269,
-0.031791013,
-0.026668102,
0.0007230842,
0.022348527,
0.02971024,
-0.0036281787,
0.018924475,
-0.0071641714,
-0.015474084,
0.0056924876,
-0.0016873336,
0.0030948168,
0.032317787,
0.01789726,
0.0057287035,
0.00411874,
-0.008402098,
0.025825258,
-0.0013473976,
-0.010186557,
0.0047475807,
0.020491637,
0.015658455,
0.0061797565,
0.024942907,
0.00755267,
-0.0010980015,
-0.015197526,
0.0048628133,
-0.02066284,
0.020241419,
-0.021176448,
-0.02760313,
-0.03155396,
0.012767765,
-0.022638256,
-0.0077963043,
-0.036373973,
-0.01463124,
-0.0059064906,
0.00097206875,
0.014222988,
-0.040377483,
0.0017367189,
-0.0055114077,
-0.011938091,
0.009086909,
0.032423142,
-0.01647496,
0.006927122,
-0.00043623746,
-0.005945999,
-0.019648794,
0.008869613,
-0.010798935,
0.021650547,
-0.0016585254,
0.008197972,
-0.010943798,
0.006499115,
-0.018884966,
-0.0055838395,
0.008836689,
-0.02812991,
-0.0019721226,
-0.01810797,
0.013241865,
0.0030174463,
0.002518654,
0.0030553085,
0.0027244263,
-0.008296743,
0.009567593,
-0.008751088,
-0.046382744,
-0.00529082,
0.009561008,
-0.013762058,
0.012089539,
0.013419652,
0.02760313,
-0.019148355,
-0.005577255,
-0.0019161525,
0.014025446,
-0.006551793,
-0.008724749,
0.015842827,
0.024086893,
-0.021044753,
0.009580762,
-0.010212895,
0.039877042,
0.007499992,
0.010199726,
-0.00027059068,
-0.0027688732,
0.01196443,
-0.13021936,
0.004336036,
0.01031825,
-0.0013424591,
-0.00016009092,
0.008856444,
-0.015184356,
0.0072300187,
-0.0046257633,
0.012846782,
-0.012833612,
-0.0012519192,
-0.011233526,
-0.007822643,
0.03592621,
0.00977172,
0.012260742,
-0.015711134,
-0.014657578,
0.034530252,
0.011523254,
-0.0045237,
0.0034141755,
-0.000027547778,
0.009198849,
-0.0090474,
-0.0078094737,
0.003990338,
-0.000730492,
0.014157141,
-0.014341513,
-0.012958722,
0.00869841,
-0.027761165,
-0.03418785,
0.014960476,
-0.022651425,
-0.002875875,
0.027287064,
-0.020544315,
-0.006508992,
-0.0014165371,
0.002986169,
-0.019938521,
0.018028954,
0.0012749657,
-0.03500435,
0.0061830487,
0.007895075,
-0.020768195,
-0.0027063184,
-0.028735703,
-0.00731562,
-0.019556608,
-0.00011204307,
-0.018186986,
-0.014565392,
0.045013122,
-0.010930629,
-0.0025153616,
0.008810351,
0.002307943,
-0.000048896665,
0.03326599,
0.028077232,
-0.009244942,
0.0005251311,
-0.02179541,
0.0063575436,
-0.0018618286,
-0.013064077,
0.0069007827,
-0.0067625036,
-0.016158894,
-0.032897245,
0.008889367,
-0.018489884,
-0.0036347634,
-0.007341959,
-0.023270387,
-0.0060151387,
-0.0059163678,
-0.002712903,
-0.016514469,
0.029815596,
0.03948196,
0.026891982,
-0.0038849828,
-0.0044644377,
0.020162402,
-0.0050932784,
0.006110617,
-0.0156057775,
-0.007289281,
0.009212018,
0.012175141,
0.0076777795,
-0.01901666,
0.01218831,
0.014881459,
-0.028972752,
-0.022638256,
-0.05083401,
0.0022042338,
0.018661086,
-0.007980676,
0.0009893536,
0.01393326,
0.019859504,
0.010285327,
-0.0031771257,
-0.010035108,
-0.029789258,
0.008988138,
-0.025390666,
0.008230896,
-0.022914814,
0.009106663,
0.0062620654,
0.014091293,
0.04456536,
0.022348527,
-0.023718148,
-0.0038191355,
0.014973645,
0.009890244,
-0.0017498884,
0.013906921,
0.012859951,
0.03526774,
-0.021571532,
0.011180849,
0.0077436264,
-0.0064563146,
-0.00755267,
-0.0079214135,
-0.016646164,
-0.015158017,
0.00086259784,
0.008382344,
0.02182175,
0.026431052,
-0.024877058,
-0.0024758533,
0.032159757,
-0.021308143,
-0.025232634,
-0.0025153616,
-0.013373559,
0.021808581,
-0.004661979,
-0.003280835,
0.015474084,
0.000039611186,
-0.032186095,
-0.021176448,
-0.02229585,
-0.002113694,
-0.010831859,
0.002021508,
-0.0059229527,
-0.031501282,
0.03366107,
0.022625085,
0.00096713024,
0.0065221614,
0.0022272803,
-0.010449945,
-0.021769073,
-0.00059221295,
0.0020939398,
-0.0046553947,
-0.0246005,
-0.0008160933,
0.0043623745,
0.008968384,
-0.010133878,
-0.0014766227,
-0.004658687,
0.020847213,
-0.0021630793,
0.040035076,
-0.004978046,
-0.0032693117,
-0.03131691,
0.024323942,
0.019899013,
0.021215957,
-0.0072629424,
0.0070917397,
-0.0152238645,
0.021940276,
-0.014973645,
0.009488576,
0.014367851,
-0.005781381,
-0.0017383652,
0.025575038,
0.014618071,
0.009574178,
0.028867397,
0.03992972,
0.020057047,
-0.012280496,
-0.008645733,
-0.04435465,
-0.00275735,
-0.0044545606,
-0.018661086,
-0.028999092,
-0.000982769,
-0.000386029,
0.016330097,
0.01581649,
-0.0036545177,
-0.0078753205,
-0.0015284773,
-0.017726056,
-0.00088564435,
0.0073485435,
-0.021900767,
-0.0011045862,
-0.0037697502,
0.0436435,
0.009442483,
-0.019556608,
0.000035752953,
-0.011793227,
0.026391543,
-0.019661963,
0.01812114,
-0.041483715,
0.009468822,
0.024416128,
-0.02812991,
-0.0018766442,
-0.011220356,
-0.038217694,
0.03508337,
0.00632462,
-0.0051426636,
0.06042136,
0.006834936,
-0.0007835812,
-0.01183932,
-0.00977172,
0.005083401,
0.023059677,
0.015131678,
0.0044150525,
-0.028156247,
0.022651425,
-0.006479361,
0.01230025,
-0.026971,
-0.040956937,
0.010140464,
-0.0064958227,
0.005024139,
-0.016422283,
0.010904291,
0.034714624,
-0.01671201,
0.019596117,
0.01069358,
-0.02670761,
-0.016119385,
0.018647917,
-0.0040463083,
-0.009212018,
-0.019319559,
-0.016632995,
0.00077987736,
-0.023046508,
-0.0064036367,
0.014420529,
-0.02391569,
-0.0011457406,
-0.040719885,
0.019609286,
-0.0042240955,
0.004164833,
0.03368741,
-0.017831411,
-0.030131662,
-0.010759426,
-0.018884966,
-0.01625108,
-0.019754149,
-0.03321331
] |
BACKGROUND The MTHFR 677C→T polymorphism has been associated with raised homocysteine concentration and increased risk of stroke. A previous overview showed that the effects were greatest in regions with low dietary folate consumption, but differentiation between the effect of folate and small-study bias was difficult. A meta-analysis of randomised trials of homocysteine-lowering interventions showed no reduction in coronary heart disease events or stroke, but the trials were generally set in populations with high folate consumption. We aimed to reduce the effect of small-study bias and investigate whether folate status modifies the association between MTHFR | [
-0.026697429,
0.0046971273,
0.002321236,
-0.03382189,
-0.04344119,
0.02705751,
-0.012474232,
0.012660703,
-0.032998845,
-0.0046006767,
0.00015843962,
-0.0059509804,
-0.0005662433,
-0.009799345,
-0.005465514,
0.0056230496,
0.040663425,
-0.019200029,
0.004253456,
0.000023384162,
-0.021682017,
0.042026587,
-0.0026539892,
0.0029176201,
0.010886018,
0.01961155,
0.018209808,
-0.039583184,
-0.0085969325,
-0.010146566,
0.0043595512,
-0.0048707374,
-0.008494052,
-0.038065698,
-0.0061149457,
-0.018595608,
0.010860298,
0.008622652,
0.01926433,
-0.020858973,
-0.0058706054,
0.012499953,
0.0030333602,
0.002094578,
-0.017888306,
-0.010609527,
-0.002059213,
0.0068222475,
-0.03495357,
0.029320875,
0.036702536,
0.0068222475,
0.0008567997,
0.009503565,
-0.0012072356,
-0.00770316,
0.0017650395,
0.0029272651,
-0.017836867,
-0.014133177,
0.01177336,
0.011940541,
-0.036445335,
0.004661762,
-0.011400419,
-0.0059059705,
-0.0020190252,
0.017026683,
-0.0009998676,
0.03551941,
0.010493787,
0.033513248,
0.0019820526,
-0.01134255,
0.021823477,
-0.0068158177,
-0.03423341,
-0.0014049587,
0.022942299,
-0.0008905573,
0.031352762,
-0.0068736877,
-0.0018679198,
0.0387087,
0.024254022,
0.004340261,
-0.0052018836,
-0.0010746166,
0.001744142,
0.00786391,
-0.0048707374,
0.014994799,
-0.009895796,
-0.0018647048,
0.0103137465,
-0.008172551,
-0.011123929,
0.012712142,
-0.0033661136,
0.0060313554,
-0.018634189,
-0.012332772,
-0.006918698,
-0.009966526,
-0.04241239,
-0.0012586757,
-0.010423057,
0.0045781718,
-0.0026138017,
-0.025900107,
-0.019868752,
0.026465949,
-0.0117090605,
-0.022376457,
-0.002097793,
0.0020817178,
0.008847703,
-0.0049093175,
-0.012577113,
-0.0033982638,
0.01970157,
0.01548348,
0.020254552,
-0.013194394,
0.009259224,
0.004134501,
-0.031815723,
-0.0012401894,
-0.016962383,
0.0075166896,
0.0074073793,
-0.0024530513,
0.01154831,
0.0012884146,
-0.027391871,
0.021129034,
-0.031841442,
-0.020383153,
-0.030606879,
-0.025514307,
0.00776103,
0.008821983,
-0.025025625,
0.0012048243,
-0.01172835,
0.01935435,
0.048482325,
0.023868222,
0.008223991,
-0.027829112,
0.0020238478,
-0.022595078,
0.03860582,
-0.0029063674,
-0.0059799156,
0.022942299,
-0.0057002096,
0.009400684,
-0.025359986,
-0.030401118,
0.013335855,
-0.029886717,
0.015830701,
0.018106926,
0.01142614,
0.022517918,
0.002123513,
-0.021540556,
0.014801898,
-0.020190252,
-0.0029272651,
0.029372316,
-0.0089955935,
0.004967188,
0.01177336,
0.0048900275,
-0.0072209085,
0.0031265956,
0.0071115983,
-0.03490213,
-0.01907143,
0.031790003,
0.042026587,
-0.0017811146,
0.0020431378,
0.013657356,
0.026234468,
-0.007433099,
-0.010924598,
-0.012339202,
-0.012319912,
0.0074973996,
-0.012339202,
-0.027829112,
-0.63003874,
-0.0126285525,
-0.02716039,
-0.019572971,
-0.008950583,
0.024073983,
0.009606445,
0.014094597,
-0.005426934,
0.013097944,
-0.0037454846,
0.040174745,
0.016100762,
-0.028137753,
-0.014969079,
-0.03086408,
0.005311194,
-0.025745787,
0.012255612,
-0.0013414623,
-0.03485069,
0.020305993,
-0.002862965,
0.0033468236,
0.01142614,
0.023109479,
0.025025625,
-0.0044431416,
-0.017669685,
0.028832195,
0.0013438734,
0.02692891,
-0.014596138,
0.01878851,
0.03912022,
-0.008937723,
0.008468332,
0.03397621,
-0.000027679213,
0.008590502,
0.0061181607,
-0.004263101,
0.030375399,
0.012737863,
0.0012755545,
0.025128504,
0.0071758986,
-0.0014724738,
0.010757417,
0.0022215708,
-0.0074266694,
0.021874916,
-0.017901165,
-0.010680257,
0.0005863371,
-0.0036426045,
0.027983433,
-0.021501975,
0.0014596138,
0.020138811,
-0.009175634,
0.01878851,
0.0068608276,
0.0064782416,
-0.0064171567,
-0.0008985948,
-0.0056841346,
-0.0020302779,
-0.0072916388,
0.007915351,
0.0019000699,
0.025064204,
-0.0072144787,
-0.0036136694,
0.03904306,
0.026851749,
0.021823477,
0.010223727,
-0.013953136,
0.024909884,
0.002655597,
0.015676381,
-0.011991981,
-0.008693382,
0.03984038,
-0.00038881507,
0.0004645687,
0.005417289,
-0.0057580797,
-0.005063638,
-0.0011003366,
-0.011059629,
-0.0012594796,
-0.0141846165,
-0.016885223,
0.012905044,
-0.004295251,
0.019277189,
0.01945723,
-0.02659455,
-0.028729314,
-0.021180475,
0.0067836675,
0.017090984,
0.0006723386,
-0.0035043592,
-0.017476786,
-0.0026716718,
0.026311629,
-0.0071244584,
0.01558636,
0.0044334964,
0.002094578,
0.0016862719,
-0.0028002723,
-0.024935605,
-0.013863116,
-0.004970403,
-0.020807534,
-0.05015413,
0.024112562,
0.021077594,
-0.0035461541,
0.013072223,
0.008603362,
0.0055748243,
0.016859503,
-0.020344572,
0.009014883,
-0.01917431,
0.023559581,
0.015097679,
0.04236095,
-0.02316092,
0.008076101,
-0.016486563,
0.040174745,
-0.007079448,
-0.0023164134,
-0.015959302,
-0.02361102,
-0.0072594886,
-0.0068608276,
-0.002337311,
-0.013798815,
-0.021591995,
-0.008706243,
-0.008236852,
-0.0023791061,
-0.011033908,
0.005465514,
-0.01536774,
-0.020948995,
0.03119844,
-0.018839948,
0.008783403,
-0.020897554,
-0.008018231,
-0.003867655,
-0.020524614,
0.007323789,
0.0036843994,
0.010056546,
0.0052983337,
-0.016692324,
0.0016685893,
-0.028137753,
0.003964105,
-0.011329689,
-0.029140836,
-0.00088251976,
-0.012236321,
0.009034174,
-0.006597197,
-0.024344042,
0.033744726,
-0.008616222,
0.000483055,
-0.030221079,
-0.0024948465,
-0.0028710023,
-0.02759763,
-0.014248917,
0.0013639673,
0.018544167,
-0.003841935,
0.014313217,
-0.021630576,
-0.012062711,
0.04943397,
0.024472643,
0.018004047,
0.0014949789,
-0.0055683944,
0.003886945,
0.016036462,
0.00579023,
-0.009272084,
-0.01586928,
0.016975245,
0.010410197,
-0.017605385,
0.01954725,
-0.032767363,
0.052597538,
-0.013811676,
0.005799875,
0.013117234,
0.0060088504,
-0.014763318,
-0.006963708,
-0.011033908,
-0.00037615598,
-0.017811146,
-0.013747375,
-0.0149819385,
0.0029288726,
-0.017605385,
0.018544167,
0.014763318,
0.01559922,
0.014763318,
0.01179908,
0.0105130775,
0.024678404,
0.0015721391,
0.02705751,
0.006507177,
0.012062711,
-0.00045612932,
-0.006539327,
0.0060442155,
0.011741211,
-0.0012313481,
0.020460313,
0.008275432,
0.00593812,
-0.028497834,
0.033436086,
0.028369233,
0.0028404598,
-0.0036811845,
0.0063432115,
-0.00040368448,
0.0017859371,
-0.013747375,
0.024266882,
0.009194924,
0.01553492,
0.04344119,
-0.006188891,
0.024549803,
0.0068929777,
-0.0072401986,
-0.013503035,
0.026620269,
-0.0070472984,
0.008590502,
0.017193865,
0.032947406,
0.01940579,
0.026028708,
-0.0076710097,
-0.0031201656,
-0.02705751,
0.015226279,
-0.007040868,
0.00097254,
0.008809123,
0.0007306106,
-0.031995762,
-0.011355409,
-0.0063946517,
-0.036471054,
-0.006195321,
-0.0008897536,
0.023109479,
0.04930537,
0.02744331,
0.008616222,
-0.012287762,
-0.037294097,
0.01992019,
0.029140836,
-0.03173856,
-0.014068876,
-0.009233504,
0.010493787,
-0.0068415375,
0.0016452805,
0.009439264,
0.0055330293,
0.013683075,
0.0040894905,
-0.0051311534,
-0.0055555343,
0.017952606,
-0.024639824,
0.016190782,
-0.012422792,
-0.03086408,
-0.016422262,
-0.014673298,
0.0052340333,
0.025848666,
0.024395483,
-0.00006138656,
0.0024401913,
0.017090984,
-0.00797322,
0.025630046,
-0.012956483,
-0.0049061025,
0.006925128,
-0.017939746,
0.014969079,
-0.00057146774,
0.024562664,
0.021360515,
-0.016409403,
-0.008577642,
-0.029192276,
-0.013284414,
0.0008270609,
0.027674792,
0.008230422,
-0.0091177635,
0.00021962526,
0.035673734,
0.018428428,
-0.005516954,
-0.032355845,
0.03485069,
-0.0068029575,
0.018518448,
-0.010410197,
0.016100762,
-0.004195586,
0.009812205,
0.02749475,
0.007343079,
-0.017656825,
-0.0064364467,
0.012821453,
0.012223462,
-0.03505645,
0.016113622,
0.031635683,
0.024871305,
0.008834843,
0.009902226,
0.04290107,
0.013683075,
-0.012493522,
-0.002126728,
0.0027407946,
0.0064653815,
0.0054751593,
0.0016091117,
-0.012577113,
-0.024022542,
-0.014969079,
0.0021411956,
-0.0012667133,
0.02726327,
-0.009259224,
0.014261777,
0.03407909,
0.00021701306,
-0.0071758986,
0.015985021,
0.0026250542,
-0.0030044252,
-0.020228833,
0.009760765,
-0.010641677,
-0.015136259,
-0.0004000676,
0.017155284,
-0.01568924,
0.008307582,
-0.022132117,
-0.018891389,
0.004709987,
-0.0067708073,
-0.018814228,
0.01992019,
-0.0011445429,
0.0016083079,
0.0048546623,
-0.016936664,
-0.028677873,
-0.010815288,
-0.016370822,
0.011702631,
-0.013046504,
-0.018749928,
0.006510392,
0.016898084,
0.020357432,
0.0030848004,
-0.03518505,
-0.018338406,
0.039943263,
-0.028652154,
-0.009047033,
-0.009194924,
-0.0019820526,
0.0014877451,
-0.020666074,
-0.008686952,
-0.021849196,
-0.009709325,
0.020781813,
0.0060120653,
-0.012480662,
0.0087576825,
-0.004591032,
-0.021759177,
0.01179908,
-0.0006124591,
0.023983963,
-0.0032696635,
0.0037486998,
0.020318853,
-0.028677873,
-0.010622388,
-0.035725173,
-0.009503565,
-0.012371352,
-0.0048803827,
-0.025990127,
0.0032664484,
0.0055812546,
0.020151673,
-0.016833784,
0.0028870774,
0.018492728,
0.021296214,
0.0383229,
-0.0037486998,
0.015740681,
0.0052468935,
-0.009953666,
0.0070858784,
-0.018171227,
0.017296745,
-0.017682545,
-0.016898084,
0.026041567,
0.037422698,
-0.04272103,
-0.013644495,
0.011258959,
-0.0068415375,
0.03467065,
-0.018685628,
-0.008314012,
-0.0154449,
-0.015663521,
-0.026054427,
-0.0230709,
-0.005388354,
0.008172551,
-0.009657885,
-0.01548348,
-0.0153420195,
-0.0064107263,
0.025334265,
-0.034336288,
0.0091563435,
-0.01154188,
-0.031995762,
0.023996823,
0.009799345,
-0.010937458,
-0.03451633,
-0.009587155,
-0.025938688,
-0.02269796,
-0.0017618246,
-0.014776178,
0.037628457,
0.018762788,
0.04313255,
-0.010564517,
0.017039545,
0.00051399943,
0.01931577,
-0.0067257974,
0.01594644,
0.013593055,
-0.028009152,
0.010609527,
0.013490175,
0.008796263,
0.017142424,
-0.00004131788,
0.0089955935,
0.04765928,
-0.020087373,
0.0025768292,
-0.0037165496,
-0.045010116,
-0.010210866,
-0.010628818,
-0.0064268014,
0.000033154774,
-0.052546095,
-0.007317359,
0.02659455,
0.008584072,
0.019817311,
-0.012101292,
0.0072209085,
-0.0077546,
0.011355409,
-0.013258695,
-0.006092441,
-0.0072787786,
-0.016460843,
0.0068929777,
0.005333699,
0.021810615,
0.010455207,
0.016563723,
-0.002544679,
-0.004308111,
0.0060538608,
0.014634718,
-0.01580498,
0.014608998,
-0.007355939,
-0.017142424,
0.007986081,
-0.012242751,
0.009394255,
-0.011889101,
-0.009310664,
0.0063303513,
-0.01901999,
-0.0048418026,
-0.017952606,
-0.0062499763,
-0.00143309,
-0.007304499,
0.019431511,
-0.020768953,
0.023623882,
0.0012426007,
-0.022466479,
-0.021887777,
0.012403502,
0.028343514,
-0.0034271989,
0.037962817,
0.022466479,
-0.0157021,
-0.0071566086,
0.0032825235,
-0.0037197645,
-0.030606879,
-0.03099268,
0.02331524,
0.009702895,
0.028446393,
-0.006188891,
0.012853603,
-0.027700512,
0.046399,
0.00039926384,
0.003465779,
-0.013618775,
-0.03078692,
-0.010217296,
0.03078692,
0.010378047,
0.00788963,
-0.011040338,
-0.019714432,
-0.01917431,
-0.013760235,
-0.0023582086,
0.0039190953,
-0.0002441397,
0.032535885,
0.0047582122,
0.00092994113,
-0.017078124,
-0.0100372555,
-0.014017437,
-0.017039545,
-0.040534824,
0.040509105,
-0.0022778334,
0.0060217106,
0.016267942,
0.009374964,
-0.0049093175,
0.0028083099,
-0.0104359165,
-0.041666508,
-0.032304402,
0.006532897,
0.021772036,
0.017708266,
-0.015907861,
0.009362104,
-0.026234468,
-0.010223727,
-0.029886717,
-0.025141366,
0.03130132,
-0.045087278,
-0.006886548,
-0.021604856,
0.008899143,
0.025244245,
0.008069671,
-0.0153420195,
-0.018467007,
0.028935075,
-0.012583543,
0.01961155,
0.005436579,
0.01907143,
0.0033918337,
-0.0047678575,
-0.021772036,
-0.029835276,
-0.010307317,
-0.009600014,
-0.04300395,
-0.0387087,
0.00027508414,
0.0041795108,
-0.0011927681,
-0.020756094,
0.041383587,
0.009645025,
0.0013953137,
0.0067515173,
-0.012262042,
0.019881612,
-0.04192371,
0.016820924,
0.0084811915,
0.007941071,
-0.003108913,
-0.022106398,
-0.0037358396,
0.007458819,
0.0004159417,
0.024819864,
-0.006266051,
0.009374964,
-0.020203112,
0.012564252,
-0.013258695,
-0.022222137,
-0.021180475,
-0.0024080412,
0.0044560013,
-0.014853339,
-0.0059316903,
0.018814228,
0.0046939123,
0.017296745,
-0.026144447,
0.00774817,
0.0061342358,
-0.011168939,
-0.0231352,
0.008185411,
-0.002363031,
0.028600713,
0.002200673,
-0.014300357,
0.0055876845,
-0.0026588119,
-0.06213968,
-0.03186716,
0.0006526467,
0.0053979987,
0.0321758,
0.015123399,
-0.005922045,
0.0013679861,
-0.0014973901,
0.00017702639,
-0.021836337,
0.0047582122,
0.0036683246,
0.0029963877,
0.017219584,
0.017335325,
-0.028652154,
-0.006847968,
0.02726327,
-0.00082063087,
-0.031841442,
0.038065698,
-0.018274108,
0.024395483,
-0.006584337,
0.03155852,
0.017283885,
-0.013991716,
0.003822645,
-0.007343079,
-0.011220379,
-0.014274637,
0.009207784,
0.0045010117,
-0.0075166896,
-0.013721655,
-0.004700342,
-0.01158689,
-0.044084195,
-0.032715924,
0.02659455,
-0.00097254,
-0.012692853,
0.024678404,
-0.012551392,
-0.003931955,
0.00040649762,
0.0045653116,
0.0067836675,
-0.013168674,
0.02317378,
0.0024144712,
0.0054558692,
-0.013618775,
-0.011889101,
-0.0016002704,
0.008873423,
-0.00043161487,
0.011001758,
-0.019650131,
-0.041383587,
-0.021193335,
0.010596667,
-0.018467007,
-0.010088696,
0.021154754,
-0.010403767,
-0.021527696,
0.018402707,
0.00012649049,
0.0059541953,
-0.0050764983,
0.0031426707,
0.010603097,
-0.008661232,
0.00582238,
0.021103315,
-0.02710895,
-0.010403767,
0.029346596,
0.17592525,
-0.002483594,
-0.00022364402,
0.024729844,
0.012512812,
0.00776746,
0.02705751,
0.0045428067,
-0.025411425,
-0.0044399262,
0.025141366,
-0.011207519,
-0.01157403,
0.0045267316,
0.021964937,
-0.0121077215,
-0.04146075,
-0.022955159,
-0.033050284,
-0.016923804,
0.011136789,
0.0040637706,
-0.0047742873,
-0.020576052,
0.006700077,
0.0015858029,
-0.012840743,
-0.024369763,
0.03117272,
-0.0074845394,
-0.02687747,
-0.011014618,
-0.0029385176,
-0.0020367077,
-0.008256141,
0.0059638405,
-0.006581122,
-0.0023582086,
-0.018595608,
-0.015033379,
-0.02723755,
0.032201525,
-0.036316734,
-0.008191841,
0.0040798457,
0.012930763,
-0.0017007394,
0.0035815192,
-0.035262212,
0.009998675,
-0.04650188,
-0.0055683944,
0.017052405,
0.034156248,
-0.0005883465,
-0.022620799,
0.035390813,
0.00021922338,
-0.0022488984,
0.013194394,
-0.0024417988,
0.006989428,
-0.01517484,
0.017476786,
-0.028343514,
0.035699453,
-0.013072223,
-0.0026266617,
-0.019727292,
-0.030632598,
0.013220114,
-0.032998845,
0.0010786353,
0.010352327,
-0.00572593,
-0.009683605,
0.031635683,
0.013040073,
0.022440758,
0.018685628,
-0.009934376,
-0.018839948,
-0.013503035,
0.01926433,
-0.009291374,
-0.035828054,
0.011078918,
0.0075809895,
-0.012905044,
0.0007482932,
0.01579212,
-0.00022505058,
-0.012390642,
0.003433629,
0.00061969284,
-0.01911001,
-0.00007540199,
-0.010127276,
-0.022209277,
-0.008854133,
-0.045575958,
0.08142973,
-0.01938007,
0.00776103,
-0.017811146,
0.007246629,
-0.0024514438,
0.029115114,
-0.0064460915,
0.01900713,
0.0033757586,
-0.04580744,
0.00020696616,
-0.0015383814,
0.010841008,
0.020293131,
0.014750458,
-0.04318399,
0.029603796,
-0.0014628288,
-0.0031973259,
-0.019277189,
0.0018550598,
0.035879493,
0.0015898217,
0.004237381,
-0.018698487,
-0.0052083135,
-0.021270495,
-0.033590406,
0.0018068347,
-0.0044527864,
0.0060024206,
0.008744823,
-0.0019466876,
0.0032825235,
0.009066324,
-0.0003044211,
0.009329954,
0.014261777,
0.00034058993,
-0.00011352998,
0.0014660438,
-0.0009854,
-0.00006997667,
-0.01945723,
-0.0018566673,
-5.7298735e-7,
-0.009130623,
0.014917638,
-0.014763318,
-0.01184409,
-0.0019579402,
0.004645687,
-0.008725532,
-0.009079183,
0.016628023,
-0.05334342,
-0.0039030202,
0.0072337687,
-0.031841442,
0.037499856,
0.030246798,
-0.007908921,
0.0075809895,
0.012840743,
-0.15853849,
0.012660703,
0.0015375777,
-0.01963727,
0.02690319,
0.00769673,
0.024974184,
-0.0023389186,
0.008101821,
0.0033211035,
0.018261246,
0.004320971,
-0.01580498,
-0.001948295,
0.0075038294,
-0.008294721,
-0.034362007,
0.018106926,
0.0029031525,
0.024768423,
0.020241693,
-0.022955159,
0.009747905,
-0.0048771678,
0.031507082,
0.013953136,
0.0060795806,
0.029655237,
-0.009059893,
0.014956218,
-0.008121111,
0.0071115983,
0.030478278,
-0.0055619646,
0.0145832775,
0.000037449823,
-0.0015914291,
-0.017759705,
0.020704653,
-0.0068029575,
0.035853773,
0.02301946,
0.0047710724,
0.00038298787,
-0.04146075,
0.024202583,
-0.0056873495,
-0.04269531,
0.020576052,
0.018145507,
0.016898084,
0.019791592,
0.03785994,
0.0037454846,
0.026723148,
-0.0006345623,
-0.008944153,
-0.016255083,
-0.009439264,
-0.008211131,
-0.008050381,
-0.01917431,
0.0026604193,
-0.009098474,
0.017013824,
-0.004687482,
-0.008796263,
-0.013863116,
-0.020074511,
0.0013784348,
-0.036625374,
0.001617953,
0.02309662,
-0.000020520794,
0.021154754,
0.0019772302,
0.0017586095,
0.006491102,
0.0028034872,
-0.008526202,
-0.011123929,
0.009137054,
-0.043338314,
-0.011554739,
-0.0014435387,
0.019122869,
0.013991716,
0.018376987,
-0.017258165,
-0.012596402,
0.021849196,
-0.03382189,
0.0066679274,
-0.025501445,
0.012622123,
0.013065794,
0.004227736,
-0.0012136656,
-0.0078832,
0.0133872945,
-0.0018679198,
-0.01159975,
-0.032304402,
-0.009407114,
0.05082285,
-0.0011236455,
-0.016730903,
0.022093536,
0.039171662,
-0.018737068,
0.0060088504,
0.0007816489,
-0.00770959,
0.031661402,
-0.010795997,
0.02314806,
-0.00012186891,
-0.01985589,
-0.0036040244,
-0.0023662462,
0.04179511,
0.0024900238,
0.01153545,
0.005417289,
-0.0059992056,
-0.0111946585,
-0.121501595,
-0.030041037,
-0.005372279,
-0.004346691,
0.004118426,
0.026028708,
-0.027983433,
-0.00052927074,
0.006622917,
0.037165496,
-0.015817842,
-0.01938007,
-0.003507574,
-0.011213949,
0.03081264,
0.007368799,
-0.007478109,
0.009503565,
-0.0074973996,
0.029140836,
-0.0044077765,
-0.040149022,
-0.029655237,
-0.014634718,
0.01187624,
-0.009522854,
-0.02290372,
-0.0020222403,
0.003141063,
0.038554378,
0.009645025,
0.005864175,
-0.011123929,
-0.0062885564,
-0.013734516,
0.008873423,
0.042026587,
-0.019045709,
0.022813698,
0.0002943742,
-0.0040284055,
0.002570399,
0.021952076,
-0.004970403,
0.024048261,
-0.008378312,
-0.048302285,
0.008069671,
0.0008278646,
-0.0052790437,
-0.011747641,
0.00772888,
-0.039454583,
-0.018608468,
0.014776178,
-0.0122684715,
0.017541084,
0.004365981,
-0.022234997,
0.0044142064,
0.012634982,
-0.0028452824,
-0.020576052,
0.02309662,
0.021926356,
-0.02298088,
-0.0029353027,
-0.045447357,
0.025527166,
-0.018286968,
0.0043145414,
0.021347655,
-0.010866728,
-0.01517484,
-0.024909884,
0.031970043,
-0.041306425,
0.0009677175,
0.0079603605,
-0.02667171,
-0.011085348,
0.0026507743,
0.019572971,
-0.028420674,
-0.022312157,
0.035596572,
0.020537473,
0.0017361045,
0.0009339599,
-0.012969344,
-0.006532897,
0.04735064,
0.00571307,
-0.0083204415,
-0.0017023468,
0.036805414,
-0.0016798419,
0.024048261,
0.046681922,
-0.00008670476,
-0.03073548,
-0.032664485,
-0.045910317,
0.022222137,
-0.004340261,
-0.013747375,
-0.0032037557,
-0.0045395917,
0.012506383,
0.0063432115,
-0.0014628288,
0.008314012,
0.0036876146,
-0.0018052271,
-0.00093717495,
0.0020463527,
-0.017528225,
0.014377517,
0.005922045,
0.015264859,
0.033153165,
0.028292073,
-0.009741475,
0.01916145,
-0.01141328,
0.03906878,
-0.0038387198,
-0.010718837,
0.008031091,
0.013657356,
-0.013335855,
0.0033918337,
0.018479867,
-0.026015848,
-0.016602302,
0.013245834,
-0.004996123,
-0.020884695,
-0.008564782,
-0.0009878112,
0.022736538,
0.01931577,
-0.028652154,
0.0061149457,
-0.012557822,
-0.008429752,
-0.00076597574,
0.010738128,
-0.051440135,
0.016550863,
-0.0040927054,
-0.008551922,
0.01932863,
0.015972162,
0.01556064,
-0.024974184,
-0.044572875,
0.01932863,
-0.0125899725,
0.014133177,
-0.0052050985,
-0.03577661,
-0.0040959204,
-0.010429487,
-0.01559922,
0.009214214,
-0.0037069046,
-0.009130623,
0.012969344,
0.001896855,
0.0012795733,
-0.021129034,
-0.025887247,
-0.00021078398,
0.012403502,
-0.0117605,
0.0078060403,
0.024807004,
-0.0023662462,
0.006982998,
0.0021733455,
0.004912533,
-0.0074652494,
-0.021682017,
-0.017926887,
0.013965996,
0.035570852,
-0.00095325,
-0.0015520452,
-0.0012924334,
0.010609527,
0.018042626,
0.007208049,
0.014801898,
0.017746845,
-0.002448229,
-0.011966261,
0.017335325,
-0.016692324,
0.020524614,
0.0004424655,
0.028780755,
0.0038162149,
0.01141328,
-0.011779791,
-0.037242655,
-0.013850256,
0.022968018,
-0.0232638,
-0.036934014,
-0.010757417,
-0.0013776311,
0.022415038,
0.010886018,
-0.016332243,
-0.0030269304,
0.008223991,
0.0052050985,
-0.0114711495,
0.0009677175,
0.013232974,
0.01187624,
-0.0018148721,
0.017836867,
0.025167085,
0.017553946,
0.013059364,
-0.0056648445,
0.044058472,
-0.022260718,
0.015316299,
-0.0027697296,
0.00584167,
0.009818635,
-0.039145943,
0.000037449823,
-0.004275961,
-0.028369233,
-0.00030301453,
0.01954725,
-0.00770959,
0.07731452,
-0.0057194997,
-0.013618775,
-0.025450006,
-0.0012040206,
0.004301681,
0.008577642,
0.0057034246,
-0.0010488965,
-0.029783837,
0.0063946517,
-0.034362007,
0.017193865,
-0.055092383,
-0.035982374,
0.020524614,
-0.005121508,
0.01932863,
-0.01179265,
-0.006487887,
0.030169638,
0.0052436786,
-0.00013935052,
-0.0036297443,
-0.012281332,
0.010281596,
0.049845487,
-0.011136789,
0.0055491044,
-0.0036136694,
-0.022505058,
-0.004327401,
-0.03117272,
0.00772245,
0.02726327,
-0.020023072,
0.01145186,
-0.0037969248,
0.015920721,
0.001056934,
-0.027777672,
0.018801369,
0.00019541223,
-0.020858973,
0.009053463,
-0.041872267,
0.004597462,
-0.012384212,
-0.018274108
] |
Functional disruption of dendritic cells (DC) is an important strategy for viral pathogens to evade host defences. In this context, porcine circovirus type 2 (PCV2), a single-stranded DNA virus, impairs plasmacytoid DC (pDC) and conventional DC activation by certain viruses or Toll-like receptor (TLR) ligands. This inhibitory capacity is associated with the viral DNA, but the impairment does not affect all signalling cascades; TLR7 ligation by small chemical molecules will still induce interleukin-6 (IL-6) and tumour necrosis factor- | [
-0.040876374,
0.004445708,
-0.0037148145,
-0.0027509073,
-0.0027073221,
0.028806577,
-0.023562921,
0.002283203,
-0.018654538,
-0.030013556,
0.00804653,
0.021752452,
0.00040526013,
0.01397414,
0.0042646606,
0.036370315,
0.022731448,
-0.010259326,
-0.0002562736,
0.001683904,
-0.029691696,
0.01731345,
-0.0035740004,
-0.029423477,
-0.0015632061,
0.021524467,
0.0118820425,
-0.033232167,
-0.02336176,
0.014805615,
0.0009924053,
0.008965176,
-0.0017601784,
0.00596449,
0.0053610005,
-0.02611099,
0.015583446,
-0.0009924053,
0.020089503,
0.006534453,
0.016455153,
0.0048916196,
-0.010842699,
-0.008529321,
0.0048446814,
0.0005959461,
0.016495386,
0.0043853587,
-0.005860556,
-0.015838252,
0.033607673,
-0.009468083,
0.0032303464,
-0.004767569,
-0.01426918,
0.0046502235,
0.0067389687,
0.0002981826,
0.013276774,
-0.041225053,
-0.004539584,
-0.0011457923,
-0.03248116,
0.004321657,
-0.01791694,
0.02003586,
0.014926313,
0.0247699,
-0.0051900116,
0.025923237,
0.04143963,
0.043022115,
0.0000560533,
0.007215055,
0.0030811504,
-0.014711739,
-0.021403769,
0.0056258654,
-0.011727817,
0.0032404047,
0.020237023,
-0.014819026,
0.018815469,
0.025628198,
0.010051457,
-0.007107768,
0.0031850848,
0.016146703,
-0.004164079,
0.0020786868,
0.0034901823,
0.03266891,
-0.0018121456,
0.031408288,
-0.018238802,
0.019995626,
0.009917348,
0.027398434,
0.0012203903,
-0.019110508,
-0.008857888,
-0.008837772,
-0.018359499,
-0.012854331,
-0.022557106,
-0.024823545,
0.009287037,
0.012586114,
0.020424776,
-0.004187548,
-0.018171746,
0.01640151,
-0.008415329,
-0.043612193,
0.05498462,
0.009662542,
0.013229836,
0.0013620429,
-0.014872669,
-0.019016633,
0.02794828,
0.0067020888,
0.009856999,
-0.017031822,
0.011734523,
-0.017541435,
-0.003129765,
-0.0033108117,
-0.024528505,
0.008757306,
0.0059711956,
0.024233466,
-0.005753269,
-0.013477937,
0.006169006,
0.012639757,
-0.026164632,
-0.009447968,
-0.016280811,
-0.015905308,
0.011747934,
0.031059606,
0.0043183044,
-0.032239765,
0.030094022,
0.040447224,
0.02462238,
0.008408624,
0.0035740004,
0.008361686,
-0.015690733,
-0.01685748,
0.020572295,
-0.02762642,
-0.006256177,
0.022999665,
-0.014819026,
0.045033745,
0.011446189,
-0.020062681,
-0.015288407,
-0.010923164,
0.0030291833,
0.0077313744,
0.02460897,
0.007852072,
-0.004200959,
0.025024708,
0.02581595,
-0.0025899769,
0.010192271,
0.004026618,
-0.032427516,
0.029208904,
-0.000023010665,
0.023804318,
-0.021189196,
0.0073893964,
-0.010547659,
-0.029584408,
-0.019016633,
-0.00881095,
0.032883484,
0.007758196,
-0.02977216,
-0.003577353,
0.017179342,
-0.016119882,
-0.013826621,
-0.0042277807,
-0.010755529,
-0.0081269955,
-0.0031146775,
-0.025131995,
-0.63471025,
-0.02413959,
0.008294631,
0.0069937757,
-0.007744785,
0.010286148,
-0.0011851868,
-0.0060416027,
-0.008435446,
0.013799799,
-0.002256381,
-0.010447078,
-0.00039268742,
-0.015985772,
-0.034251396,
-0.031408288,
0.0038388653,
0.0064573404,
0.028001923,
0.013424294,
-0.005615807,
0.0038254545,
0.0030710923,
0.0040366757,
-0.0048010964,
0.0068630194,
0.027975103,
0.01238495,
0.014939724,
0.015865074,
-0.021524467,
0.012036268,
-0.00872378,
-0.020183379,
0.054609116,
0.020263845,
-0.02535998,
0.030845031,
0.015556624,
0.023160595,
-0.0069602486,
0.01607965,
0.009521727,
0.014979957,
-0.027867815,
-0.00052763446,
-0.0124654155,
-0.0048547396,
-0.0061187153,
-0.016562441,
0.008013003,
0.006973659,
-0.019633533,
0.014497165,
0.015610268,
-0.00025082543,
0.017434148,
-0.018909344,
0.014456932,
0.019070275,
0.015248174,
0.016656317,
0.001525488,
-0.018842291,
0.004874856,
0.004405475,
-0.01534205,
0.00903223,
0.0084555615,
-0.0121234385,
0.010447078,
0.02640603,
0.017286628,
-0.008287926,
0.009012113,
0.025252692,
0.009816767,
-0.0019747526,
-0.011137739,
0.026043935,
-0.0023368464,
-0.010406845,
-0.03612892,
0.015596857,
0.020304076,
0.011131033,
-0.017782832,
0.031622864,
-0.007865483,
-0.0035371205,
-0.000016540962,
0.019271439,
-0.0075168,
-0.02553432,
-0.011519949,
0.015462749,
-0.00826781,
-0.021846328,
-0.0077313744,
0.007483273,
-0.015449338,
-0.008207461,
-0.010842699,
-0.010594598,
0.04009854,
0.007805134,
-0.043531727,
-0.0082275765,
0.0667862,
-0.04420227,
0.008395213,
-0.007148001,
0.015556624,
0.00010351525,
0.021028265,
-0.019298261,
0.016642906,
0.012706812,
-0.010654947,
-0.014255769,
0.014523987,
-0.010990219,
0.000108230015,
-0.028592004,
-0.002162505,
0.015462749,
-0.004673693,
-0.0052067754,
-0.019325083,
-0.02931619,
0.00047315273,
0.0038958616,
0.009380912,
-0.012659874,
0.0248906,
0.027975103,
0.024676025,
0.0060080756,
-0.012840921,
-0.026352385,
-0.030549992,
-0.004499351,
0.00012970838,
0.004861445,
0.0012438594,
-0.00656798,
0.00008979005,
0.005776738,
0.02066617,
-0.012237431,
-0.0005565517,
-0.027264325,
0.0059980173,
0.012720223,
0.0042311335,
-0.011037157,
-0.0049385577,
-0.017983994,
0.015020189,
-0.021309894,
0.0036578183,
0.00622265,
0.010225798,
-0.006018134,
-0.0040366757,
-0.0026201513,
0.009501611,
0.01699159,
0.008408624,
-0.022409586,
0.004143963,
0.0011566887,
-0.008287926,
0.019486014,
-0.0037684583,
0.017554846,
0.016495386,
0.013263363,
-0.026070757,
-0.004308246,
0.0125928195,
-0.0248906,
0.0057800906,
0.0071278843,
0.015999183,
0.0019797815,
0.029182082,
0.014644684,
0.0007241877,
0.037872333,
0.0019781052,
-0.0024625733,
-0.01609306,
0.0050123176,
-0.002492748,
-0.017836474,
0.018104693,
0.026687657,
0.0075570326,
0.041546915,
0.00804653,
-0.029047973,
0.012854331,
-0.02371044,
0.009555254,
-0.01760849,
-0.005957785,
-0.035914347,
0.012156965,
0.009803356,
-0.0033108117,
0.012130144,
-0.016347867,
0.010272737,
-0.018909344,
0.040313113,
-0.012793982,
-0.006772496,
-0.0070876516,
-0.008140406,
-0.021685397,
-0.012170376,
0.022597339,
-0.005629218,
-0.005424702,
0.0011784814,
0.0014483754,
0.01868136,
-0.008515911,
-0.02462238,
-0.024153,
-0.0060918937,
0.011251731,
0.011063979,
-0.0137595665,
0.016455153,
-0.0048949723,
0.015476159,
0.04672352,
0.0011013688,
0.011949097,
0.022235245,
0.008515911,
0.0020870687,
0.009394323,
-0.016307633,
0.016964767,
0.008737191,
-0.019351905,
0.006688678,
-0.0016730076,
-0.009421146,
-0.027049752,
-0.014832437,
0.0005158999,
-0.008448856,
0.0017970584,
-0.011888748,
0.047501348,
0.015529803,
0.0066350345,
-0.02126966,
0.03127418,
-0.010641536,
0.014926313,
0.013699217,
0.0021323303,
-0.0129347965,
-0.018305855,
0.016683139,
-0.003962916,
0.0029805687,
0.012572703,
-0.018748414,
0.010386729,
0.01653562,
-0.008764012,
0.009997813,
0.014591041,
0.0051095467,
-0.0104604885,
-0.036477603,
0.009769828,
0.013464526,
-0.0051330156,
-0.022195011,
-0.02371044,
-0.012391656,
-0.016039416,
-0.001534708,
-0.006098599,
0.01853384,
0.023562921,
0.006004723,
-0.017407326,
-0.0023066718,
0.011372429,
-0.012968324,
0.0032253175,
0.016455153,
-0.0023066718,
0.0031130014,
-0.016937945,
-0.01443011,
0.030657278,
0.019298261,
0.007805134,
-0.00934068,
-0.002633562,
-0.0073089316,
-0.00189764,
-0.003381219,
-0.008006297,
-0.032990772,
0.0064271656,
0.030308597,
-0.004723984,
0.006088541,
0.018909344,
0.018574074,
-0.026057346,
-0.034948763,
0.017286628,
-0.021028265,
0.012452005,
0.023683619,
-0.018185157,
0.010198977,
0.001512077,
0.003976327,
-0.008764012,
-0.02840425,
0.032883484,
-0.021537878,
-0.0008809274,
-0.0049955538,
-0.011580298,
-0.0051564844,
0.020679582,
0.013853442,
0.00081638753,
-0.015623678,
-0.0052436553,
0.0056493348,
0.00372152,
-0.015020189,
0.020250434,
0.03631667,
0.02778735,
0.00081974023,
0.013008556,
0.02762642,
0.0011776432,
-0.0067054415,
-0.0073156366,
0.014349645,
-0.0057633272,
0.025896415,
-0.01238495,
-0.028055567,
0.0051363683,
0.009756418,
-0.0024877188,
0.022449818,
0.02474308,
0.02397866,
0.016870892,
-0.006785907,
0.007080946,
-0.013410883,
-0.0071882335,
-0.002799522,
-0.0020786868,
-0.018426554,
0.04020583,
-0.00037319973,
0.014349645,
-0.0209478,
0.00049284997,
-0.013089022,
0.00078160304,
0.0107018845,
-0.0041473154,
-0.0084555615,
-0.02458215,
-0.012787277,
0.00070951955,
-0.015610268,
-0.015677322,
-0.019834695,
0.009897232,
-0.008422035,
-0.024233466,
-0.019660356,
-0.0038757452,
-0.025896415,
-0.020786868,
0.0057800906,
-0.00064162695,
0.0066719144,
0.02384455,
-0.014912902,
0.00910599,
0.029745338,
-0.009193161,
-0.03248116,
-0.0007409513,
-0.034573257,
0.009159633,
0.009917348,
-0.008985292,
0.022382764,
-0.017876707,
0.0038757452,
-0.006665209,
0.0068630194,
0.0025178932,
-0.0038824508,
-0.006578038,
0.045731112,
0.016884303,
0.0300672,
0.00020640188,
-0.02325447,
-0.0012094941,
-0.03478783,
-0.014068017,
-0.016334455,
-0.014081427,
-0.027572775,
0.007168117,
0.016629495,
-0.014792204,
-0.007650909,
0.025145406,
-0.022154778,
-0.010433667,
-0.00032290892,
0.022288889,
0.032615267,
0.0048580924,
0.0060918937,
0.006413755,
-0.043022115,
-0.015328639,
-0.01381321,
0.01147301,
0.01653562,
-0.018748414,
0.007650909,
0.009696068,
-0.021296483,
-0.011761345,
-0.015529803,
-0.020451596,
0.015730966,
0.008026414,
0.006920016,
-0.016361278,
0.0066719144,
-0.00053475896,
0.006169006,
-0.0009764799,
-0.016334455,
-0.0052939462,
0.022315709,
0.010111806,
-0.020250434,
0.030737745,
-0.031703327,
-0.015382283,
0.025306337,
0.003590764,
0.026741302,
-0.0066853254,
-0.007577149,
-0.016937945,
-0.013256658,
-0.02202067,
-0.043907233,
-0.01063483,
-0.023348348,
0.02977216,
0.015516392,
0.04680398,
-0.02428711,
0.0012287722,
0.018265624,
-0.009072462,
0.0033141645,
-0.0028347254,
0.0024961007,
-0.026634013,
0.015999183,
0.011278553,
-0.019365314,
0.014859258,
-0.023106951,
0.04009854,
-0.008247693,
-0.0027173802,
-0.043183044,
0.0034080406,
-0.010172155,
-0.020277256,
-0.007650909,
-0.0036913457,
-0.0029135144,
-0.019150741,
-0.0085963765,
0.02216819,
-0.017943762,
-0.001362881,
-0.0055454,
0.018748414,
-0.005837087,
0.015798021,
-0.011667469,
0.023737263,
0.016455153,
-0.014215536,
0.0018372909,
0.010594598,
0.02507835,
-0.003102943,
0.011278553,
0.015315228,
0.007671025,
-0.0012815775,
0.01607965,
-0.008670136,
-0.025279514,
0.012867742,
-0.02824332,
-0.030147666,
-0.032293405,
-0.00759056,
-0.035646126,
0.0024491625,
-0.011486421,
-0.015100654,
0.023951838,
-0.0030291833,
-0.029557586,
0.026888821,
0.0021993848,
0.022811912,
-0.036531247,
0.02702293,
0.0073491638,
-0.016280811,
-0.043960877,
-0.015972361,
0.009816767,
-0.0024692789,
0.041359164,
0.034090467,
-0.004673693,
-0.006772496,
-0.0052034226,
-0.001716593,
-0.009555254,
-0.010353202,
0.011674174,
0.011660763,
0.00009466198,
-0.009957581,
-0.028940685,
-0.009045641,
-0.00987041,
-0.027277736,
0.02428711,
-0.016146703,
-0.013618751,
-0.01025262,
0.004972085,
-0.011157854,
0.007503389,
-0.013229836,
0.00067389687,
-0.014175303,
-0.026634013,
0.022154778,
-0.012284369,
0.0041037304,
0.014349645,
0.018185157,
0.00520007,
0.0053610005,
0.006926721,
0.0062125917,
0.012726928,
-0.017353684,
0.050612673,
-0.00934068,
0.007818545,
0.015610268,
0.009159633,
0.0137595665,
0.005669451,
-0.0031515576,
-0.01213685,
-0.032293405,
-0.023951838,
0.019472603,
-0.0005112899,
-0.0131627815,
0.023120362,
-0.011117622,
-0.0068864883,
-0.0418956,
-0.02853836,
0.03309806,
-0.01898981,
-0.016428333,
-0.010011224,
-0.0023083482,
0.025856182,
0.011962508,
0.026513316,
-0.015610268,
0.030845031,
-0.039535284,
0.0027794056,
-0.004133905,
0.0059711956,
-0.040474046,
0.0020183378,
-0.01913733,
-0.03776505,
0.008220871,
-0.018775236,
-0.017823063,
-0.031810615,
-0.004814507,
0.0009689363,
0.015811432,
-0.014845848,
0.035780236,
-0.0044691768,
0.010044752,
-0.0069803647,
-0.020518651,
0.022463229,
-0.011613824,
0.006735616,
0.00328399,
-0.015757788,
-0.01147301,
0.013920497,
0.0015573387,
-0.0010242562,
-0.0021273014,
-0.02961123,
-0.01607965,
0.002135683,
0.0018507019,
-0.001521297,
-0.019204386,
0.006195828,
-0.0072821095,
-0.00064120785,
-0.006155595,
-0.010145333,
-0.0009840236,
-0.01822539,
-0.004395417,
0.021658577,
-0.006396991,
-0.013122549,
0.012257547,
-0.031086428,
-0.020371132,
-0.008924942,
-0.033634495,
0.0033611027,
0.010373319,
0.002004927,
-0.009501611,
-0.0017417384,
-0.027157038,
-0.027264325,
0.011466305,
0.009950875,
-0.0013184574,
0.018614305,
-0.01594554,
0.004915089,
-0.0029805687,
0.015570035,
0.011774755,
-0.017782832,
-0.003307459,
0.00088428013,
0.031998366,
0.011117622,
-0.013772977,
-0.018869113,
0.033205345,
0.005615807,
-0.008160522,
0.023415402,
0.0021189195,
-0.00060265156,
-0.01715252,
-0.006819434,
-0.003433186,
-0.00044758822,
-0.0005875643,
0.011151149,
-0.013156076,
0.0019311672,
-0.0064405766,
-0.0017266512,
0.007872188,
-0.004107083,
-0.0042814245,
0.00379528,
0.0044155335,
-0.033044416,
0.028055567,
-0.02262416,
0.013618751,
0.015288407,
0.010976808,
0.005843792,
0.029396655,
-0.005267124,
-0.00089098554,
-0.009964286,
-0.022087725,
-0.0032068775,
0.019727409,
0.00019634371,
-0.013625457,
0.00189764,
0.035914347,
-0.031381465,
0.008220871,
-0.01518112,
0.017434148,
-0.044550955,
0.025118584,
-0.020022448,
-0.006544511,
-0.015771199,
-0.02778735,
-0.014470343,
-0.0077649015,
0.003460008,
0.009441262,
-0.010480605,
-0.009776534,
0.0021792685,
-0.010058163,
0.00022672775,
-0.006474104,
-0.0038623344,
-0.007396102,
-0.00075017125,
0.1923657,
-0.0031012667,
0.011613824,
0.02731797,
-0.0055521056,
0.013377356,
0.0072485823,
-0.014322823,
-0.0027760528,
-0.005642629,
0.0352438,
0.00021855549,
-0.0007338268,
0.0007065859,
0.01063483,
-0.004341773,
-0.018748414,
-0.014483754,
-0.029396655,
-0.026754713,
0.024233466,
-0.013149371,
0.024112768,
-0.014376467,
0.0346269,
-0.01457763,
-0.022597339,
0.017501203,
0.013598636,
0.01791694,
-0.021135552,
0.014899491,
0.0037248728,
0.0101051,
0.02141718,
0.0024307226,
-0.010084984,
-0.005283888,
0.010876226,
-0.001325163,
0.016481975,
-0.012250842,
-0.020894157,
0.0018423201,
-0.0098771155,
0.021162374,
0.010795761,
-0.019941984,
-0.0053475895,
-0.004442355,
-0.030469527,
0.0062494716,
0.0036242912,
0.023603154,
-0.017259806,
-0.009280331,
0.026017113,
0.0067054415,
-0.022691214,
0.025239281,
-0.034412324,
0.01837291,
-0.0040031485,
0.023415402,
-0.01653562,
0.029128438,
-0.012954913,
0.0038623344,
0.012177082,
-0.024367575,
0.021242838,
-0.00012342204,
-0.019660356,
-0.015476159,
-0.025748895,
-0.022811912,
0.020760046,
0.022811912,
0.042083353,
0.016669728,
0.00048069636,
-0.006819434,
-0.031971544,
0.022154778,
0.021779275,
-0.0352438,
0.037282255,
-0.016347867,
-0.023227649,
0.012545881,
0.008100173,
-0.0049888487,
-0.010205682,
-0.0009915672,
0.019982215,
-0.008737191,
-0.01653562,
-0.005857203,
0.016146703,
-0.036048453,
-0.025829362,
0.10342473,
0.0189764,
-0.00095887814,
-0.0044021225,
0.03966939,
0.010876226,
-0.005129663,
-0.0037718108,
-0.012156965,
-0.00052763446,
-0.011157854,
0.0109432805,
-0.00040945102,
-0.0028481362,
0.01237154,
0.04052769,
-0.026298743,
0.019418959,
0.0038019854,
0.010903048,
-0.013504759,
-0.002851489,
0.0195933,
0.003069416,
-0.0073491638,
-0.028028745,
0.009360797,
-0.00036586565,
-0.028162854,
-0.00508943,
0.0016143351,
-0.0034315097,
0.0037550472,
0.018037638,
0.00139557,
0.026338974,
-0.02446145,
-0.0096357195,
-0.00046309456,
-0.015368872,
-0.004683751,
0.017286628,
-0.0039059196,
-0.013001851,
0.004911736,
0.019190975,
-0.00056158076,
-0.01837291,
-0.019968806,
-0.011875337,
-0.028189676,
-0.0056493348,
0.0011189706,
0.008375096,
-0.028162854,
-0.019459192,
-0.011211499,
0.0017735893,
-0.009716185,
-0.026312152,
-0.011647352,
0.023643387,
-0.01518112,
-0.02249005,
0.0022982901,
-0.16865526,
0.010903048,
0.00025061588,
-0.013223131,
0.022731448,
0.008985292,
0.016294222,
0.0035471786,
-0.0049251467,
0.01063483,
0.020129737,
0.031086428,
-0.011573592,
-0.0056962725,
0.008375096,
0.010903048,
-0.010802466,
0.017018411,
0.01032638,
-0.0030643868,
0.039749857,
-0.03309806,
-0.003651113,
-0.016052827,
0.00011063978,
0.01746097,
-0.0062997625,
-0.0038992143,
-0.010111806,
-0.010192271,
-0.0008356657,
-0.00019361962,
0.035753414,
-0.025024708,
0.02990627,
-0.01882888,
-0.0060784826,
-0.0015967332,
0.0065813907,
0.032454338,
0.032722555,
0.007912421,
0.0066316817,
-0.011700995,
-0.012009446,
0.02731797,
-0.02397866,
-0.021792686,
0.01162053,
-0.002683853,
0.035646126,
-0.008308042,
0.0050860774,
0.027706884,
0.013498054,
0.024823545,
-0.0056023966,
0.0077045523,
-0.0055152257,
0.004935205,
-0.009494905,
-0.002990627,
0.0094882,
-0.01101704,
0.00038723924,
-0.04082273,
-0.00020242052,
0.041546915,
-0.023442224,
0.0043183044,
-0.029584408,
-0.018962989,
0.009354091,
-0.01609306,
0.02762642,
0.010239209,
-0.017179342,
0.012847626,
0.0049955538,
0.007818545,
-0.014658095,
0.004539584,
-0.034251396,
-0.021537878,
-0.024635792,
-0.013156076,
0.00857626,
0.02886022,
0.011821694,
-0.0029369835,
0.010259326,
-0.02641944,
0.026580371,
-0.015771199,
-0.0004107083,
0.029557586,
0.0069334265,
0.009287037,
-0.0300672,
0.0018674654,
-0.00091696915,
-0.012834216,
-0.0010049781,
0.015865074,
-0.018104693,
0.00064497965,
-0.015543214,
0.009810061,
0.04058133,
-0.009374207,
-0.0065243947,
-0.0012597848,
0.0061991806,
0.007201644,
-0.002442457,
0.021336716,
-0.00012488884,
0.0036343494,
0.0071748225,
-0.027425256,
0.06657162,
-0.008153817,
-0.0016621114,
0.010084984,
-0.017206162,
-0.018614305,
-0.14977275,
-0.02384455,
0.021390358,
0.011955802,
-0.035351086,
0.020129737,
-0.00467034,
0.003092885,
-0.017876707,
0.010440373,
-0.013726039,
-0.0018657892,
-0.006329937,
-0.008059941,
0.014135071,
-0.017983994,
0.0069468375,
-0.0068395506,
-0.004224428,
0.030254953,
-0.0102325035,
-0.015502981,
0.0061991806,
-0.005491757,
-0.004482588,
-0.009240098,
-0.010534248,
0.02627192,
0.00024013863,
0.014510576,
0.0053844694,
-0.0021055087,
0.020277256,
-0.0025849477,
-0.024153,
-0.003986385,
-0.00037403792,
-0.029074796,
0.037121326,
-0.0065847435,
-0.0059879594,
0.003218612,
-0.006085188,
0.013947318,
0.0113992505,
-0.009749712,
-0.015020189,
0.018158335,
0.017112287,
0.0020183378,
-0.027063163,
-0.022060903,
-0.02886022,
-0.004107083,
0.006541158,
-0.021336716,
0.019043455,
0.04616026,
-0.011097506,
-0.00432501,
0.01837291,
-0.0032119064,
-0.023643387,
0.027304558,
0.034707367,
-0.023133773,
-0.008556143,
-0.016106471,
0.016186936,
-0.043102577,
-0.009186455,
-0.029047973,
-0.015368872,
-0.016803836,
-0.017098876,
0.012452005,
-0.02110873,
0.009622308,
0.0012086559,
-0.00470722,
-0.017930351,
-0.019271439,
0.027116805,
-0.0041104355,
0.02931619,
0.010567776,
-0.009474789,
0.0032404047,
0.009193161,
-0.0016880949,
-0.0054347604,
0.025775718,
0.007335753,
-0.017192753,
-0.027653242,
0.019781053,
-0.011707701,
-0.011654058,
0.020545473,
0.04020583,
-0.03097914,
-0.007711258,
-0.056432996,
0.01912392,
-0.014470343,
0.011191382,
-0.0011147796,
-0.0032940481,
-0.007892305,
0.00007889371,
0.017434148,
0.012069795,
-0.030013556,
-0.0005485889,
-0.024018891,
0.02762642,
-0.028833399,
-0.03961575,
0.038623344,
-0.0060818354,
-0.0013368974,
0.027653242,
0.01040014,
-0.015355461,
0.009863704,
0.027921459,
0.000042590033,
-0.004143963,
0.0060818354,
0.029208904,
-0.014483754,
-0.0015497952,
-0.008770717,
-0.028109211,
-0.03489512,
0.00979665,
-0.0024022243,
-0.006772496,
-0.0076106763,
0.037711404,
0.016481975,
0.02367021,
-0.01806446,
-0.044577777,
0.0069602486,
-0.0129213855,
-0.0004664473,
-0.0053375317,
-0.049405694,
0.022288889,
0.0026486495,
-0.015891897,
0.029128438,
0.00804653,
-0.01790353,
-0.010306263,
-0.0023217592,
0.015610268,
0.009018819,
-0.021846328,
-0.0056627453,
-0.019043455,
0.006852961,
0.019003222,
0.029477121,
0.015583446,
0.021806097,
-0.019325083,
-0.043692656,
-0.0055420473,
0.0040165596,
0.0010074927,
-0.024059124,
0.016106471,
0.015851663,
-0.007275404,
-0.010862815,
-0.0021759158,
-0.008536027,
0.0056593926,
-0.014819026,
0.019995626,
-0.0040366757,
0.0051732482,
-0.021537878,
0.0034834768,
0.039642572,
0.0133035965,
-0.003952858,
0.015771199,
0.0012505648,
0.0065378053,
0.010299558,
0.022959432,
0.016790425,
0.0070876516,
0.018949578,
0.017286628,
0.003470066,
0.000042799576,
0.006155595,
0.021886561,
0.014939724,
-0.0016227169,
0.0046636346,
-0.028377429,
0.009924053,
0.016026005,
-0.020706404,
-0.051685542,
-0.007959359,
0.020679582,
-0.0111712655,
-0.013377356,
0.017648723,
-0.0019529598,
-0.014148482,
0.014322823,
-0.0040567922,
0.014202125,
-0.020156557,
0.022248656,
0.007456451,
0.0041473154,
-0.00077238306,
-0.0010410198,
-0.0013980846,
0.013498054,
0.022315709,
-0.042458855,
0.028055567,
-0.0011474687,
0.014376467,
0.01032638,
-0.033822246,
-0.015274996,
0.010091689,
-0.0006013943,
-0.005823676,
0.02778735,
-0.017863296,
0.071238615,
0.015865074,
-0.017139109,
-0.025762307,
-0.041520093,
0.018627716,
0.0022547047,
0.010862815,
-0.0020183378,
-0.02671448,
0.022248656,
-0.011104211,
0.020089503,
-0.030925497,
-0.030174486,
0.02462238,
-0.0067155,
0.00007072146,
0.011084095,
-0.00003405107,
0.01215026,
-0.020009037,
0.0062394133,
0.014376467,
-0.045650646,
-0.015972361,
0.016294222,
-0.0069602486,
0.0018909345,
-0.037255432,
0.017796243,
0.0034197753,
-0.025185639,
-0.018855702,
-0.0015497952,
0.0023921663,
-0.0129347965,
-0.026513316,
0.009380912,
0.03628985,
-0.0048916196,
0.032856666,
-0.03583388,
-0.038837917,
-0.006256177,
-0.0041573737,
0.0038221017,
-0.01807787,
-0.0052771824
] |
Women with a history of hypertensive pregnancy are at greater risk for future cardiovascular events; however, the mechanisms for this increased risk are unknown. Evidence suggests that an exercise stimulus unmasks latent hypertensive tendencies, identifying individuals at the greatest risk for developing cardiovascular disease. The current study examined the hypothesis that women with a hypertensive pregnancy history exhibit an augmented exercise pressor response. Normotensive women with a history of healthy pregnancy (CON; n = 9) and hypertensive pregnancy (HP+; n = 12) were studied during the mid-luteal phase of the menstrual cycle. Heart rate (HR), systolic and di | [
-0.03522422,
-0.013756986,
0.0065946397,
-0.037706286,
-0.025177132,
0.012152884,
-0.009386964,
0.0016214298,
-0.022140563,
-0.017176429,
-0.015182854,
0.013413722,
-0.009499186,
0.0013441776,
-0.005964221,
0.005069753,
0.0510672,
0.0015611935,
0.0079082865,
-0.03208203,
-0.009248339,
-0.004165383,
0.006805879,
0.01021212,
-0.033719137,
-0.0030811292,
0.01234432,
-0.033006202,
0.007703648,
-0.03276856,
-0.009499186,
0.0133741135,
-0.0029111472,
-0.013783391,
-0.020609073,
-0.011664392,
-0.012482947,
-0.0074792057,
0.015288474,
-0.000120782075,
-0.00111726,
0.010047088,
-0.015710954,
0.005178673,
-0.006957708,
0.0045581567,
0.025467588,
-0.023526823,
0.0028764906,
0.01462835,
0.026404964,
-0.0017509791,
0.006885094,
0.038868107,
-0.016410684,
0.010093297,
-0.011888835,
0.02809488,
-0.006102847,
-0.03469612,
-0.002729613,
-0.0021338512,
-0.02846455,
0.023262773,
-0.008819258,
0.0038848303,
-0.013288298,
0.038841702,
-0.0028913436,
-0.008509,
0.023909694,
0.018773928,
-0.00015048766,
0.003713198,
0.000009192743,
-0.020873124,
-0.020820314,
-0.022840293,
0.008786252,
0.0031141352,
0.018430665,
-0.0009819346,
-0.011737006,
0.0089314785,
0.008779651,
0.013466531,
-0.020503454,
0.0070039164,
0.0058057914,
-0.024701843,
0.013915416,
-0.012945034,
-0.010218721,
0.017334858,
-0.010264929,
0.011552172,
-0.0017245741,
0.009637811,
-0.0074395984,
0.00093077496,
-0.012601769,
0.0041719843,
-0.018417463,
-0.010892048,
-0.015262069,
0.008891871,
-0.024556616,
-0.01659552,
0.018985169,
-0.022695066,
-0.0075782244,
0.029520748,
-0.005792589,
-0.03926418,
0.014324693,
-0.028596574,
-0.0064659156,
0.000007851867,
-0.006627646,
-0.00867403,
0.0112617165,
0.00287319,
0.02967918,
0.01850988,
0.020780707,
0.018681511,
-0.027197111,
-0.011235312,
-0.008951282,
-0.0009934867,
-0.012720591,
0.0057232757,
0.0070435237,
-0.0062480746,
-0.042221535,
0.0059972275,
0.003729701,
-0.01457554,
-0.026312545,
-0.045627777,
-0.0077630593,
0.02835893,
-0.043753024,
-0.007914888,
-0.02558641,
0.031448312,
0.024569819,
0.01878713,
-0.0027213616,
0.00054584007,
-0.011004268,
-0.008905074,
0.004822206,
-0.013928618,
-0.0041884873,
0.0015455155,
-0.015975002,
0.004693482,
-0.013110064,
-0.011393742,
0.020212999,
0.002883092,
0.009327553,
0.010027285,
-0.0050664525,
0.00037193866,
-0.0024919685,
-0.018734321,
0.01180962,
-0.019434053,
-0.015222461,
-0.004102671,
-0.03889451,
0.0015752211,
0.019777317,
0.018166615,
-0.0076310346,
-0.007829072,
-0.0061523565,
-0.03150112,
-0.021572854,
0.02398891,
0.026669012,
0.0033715838,
-0.009413369,
0.016767152,
0.017757338,
-0.038234387,
0.007822471,
-0.029996037,
-0.017585706,
0.035303436,
-0.021982132,
-0.003160344,
-0.65188575,
0.010443163,
-0.011552172,
0.0029293005,
0.030471327,
0.024120934,
0.012218896,
0.011248514,
-0.012931831,
0.031580336,
-0.012793205,
0.01297804,
-0.0011024072,
0.009122915,
0.00047033842,
-0.026246533,
0.0021239491,
-0.007565022,
0.017466882,
-0.0021289003,
-0.0024721646,
0.01446992,
-0.0050631515,
0.01878713,
0.045046866,
0.022615852,
0.0037363023,
-0.01766492,
-0.010297935,
0.03197641,
0.022483826,
0.035065793,
0.005347005,
-0.0006753894,
0.050512694,
-0.015275272,
-0.010258328,
0.030550543,
0.008700435,
0.04634071,
-0.035065793,
-0.014034238,
0.011585178,
0.008614619,
0.0050532497,
0.025982484,
0.0228799,
-0.01606742,
0.034009594,
0.006188663,
0.0036669893,
-0.009353958,
-0.008660828,
0.008515601,
0.00017534546,
-0.0065814373,
-0.0005169597,
-0.0049179243,
-0.024728248,
-0.018391056,
-0.00034099535,
0.016503101,
0.011373938,
-0.0007480031,
0.010126303,
0.03973947,
-0.007274567,
0.009677419,
-0.023051532,
-0.0064296084,
0.0028698894,
0.021506842,
0.0042379964,
-0.014932007,
0.032108434,
0.012357523,
0.017625313,
-0.0041554812,
-0.025705231,
0.015090437,
-0.00088374113,
0.0002333126,
-0.0244642,
-0.0042115916,
0.032636534,
-0.013360911,
-0.024134137,
0.02521674,
-0.005102759,
-0.013545746,
0.0028847423,
0.007776262,
0.0019506667,
-0.010766624,
-0.011347533,
0.027408352,
-0.011565374,
0.009723628,
0.010429961,
0.00033707585,
-0.015684549,
0.007426396,
0.0013862606,
0.015130044,
0.00028014014,
0.010476169,
-0.029177485,
-0.012760199,
0.029467938,
-0.027645996,
0.005581349,
0.0042644017,
-0.004092769,
-0.022114156,
0.004119174,
-0.02814769,
0.010878845,
-0.007215156,
-0.00044682148,
-0.019975355,
0.019143598,
0.0010982815,
0.00648902,
-0.006426308,
0.0029111472,
0.017321656,
-0.008997492,
-0.0041521806,
0.0134995375,
-0.044994056,
0.018153412,
-0.004650574,
0.02867579,
0.0044459356,
0.023368392,
-0.022615852,
0.014483122,
0.010819433,
0.015314879,
0.006356995,
-0.019381244,
-0.0036042775,
-0.012014259,
-0.000100514204,
0.005558245,
-0.0383136,
0.0027857237,
0.0015405646,
0.0063602957,
-0.0028121285,
-0.009380363,
-0.024358578,
-0.017625313,
0.015776966,
0.012139682,
-0.0037759098,
0.0025893366,
-0.018536285,
-0.014100251,
-0.015842978,
0.012958236,
0.0013384016,
-0.024583021,
0.011486159,
-0.0031702458,
-0.034300048,
-0.037547857,
-0.0009563548,
-0.011499361,
-0.024186946,
0.010832637,
-0.038604055,
0.013955023,
0.029916823,
-0.0084033795,
0.0085288035,
-0.0035811733,
-0.016965188,
-0.019420851,
0.010462967,
0.02186331,
-0.033771947,
-0.025612814,
-0.0009208731,
0.017057607,
0.007571623,
0.011301325,
0.008614619,
0.012806407,
0.020120582,
-0.01878713,
0.021533247,
-0.024213351,
0.017849755,
-0.010449764,
-0.021506842,
-0.0056275576,
0.002079391,
0.007492408,
0.03527703,
0.047766577,
-0.0044723405,
-0.0019407648,
0.0084033795,
0.031342693,
-0.026352154,
0.01712362,
-0.011235312,
0.027355542,
-0.0028154291,
-0.01314307,
-0.0014514478,
-0.009175724,
-0.023962503,
-0.023883289,
-0.0042115916,
-0.006244774,
-0.01021212,
-0.0014093649,
0.01074682,
0.014509527,
-0.008066717,
0.022576243,
0.0022163666,
-0.023170356,
0.024002112,
0.011578577,
0.016252255,
0.006294283,
-0.006294283,
0.00039029837,
0.017849755,
0.0037197992,
-0.0033121726,
-0.0059180125,
-0.002048035,
0.013380715,
-0.017044405,
0.0053206002,
0.025401575,
0.008079919,
-0.014285085,
0.015103639,
-0.022206575,
0.012423535,
-0.005921313,
0.035145007,
-0.0014077146,
-0.0043865247,
0.0035349645,
0.009433174,
0.008106324,
0.0067035602,
0.014984816,
-0.011202306,
0.005670466,
-0.009882057,
0.0015735708,
0.0180874,
0.016054217,
0.023474012,
0.018311841,
0.007419795,
-0.0043436163,
0.004944329,
-0.005307398,
0.0138097955,
-0.005089557,
-0.00013738833,
-0.0019242617,
-0.032161247,
0.0063701975,
0.0063966024,
-0.019618887,
0.01883994,
0.0098028425,
0.025150727,
0.0101461075,
0.02851736,
0.0025266248,
-0.018747523,
-0.032900583,
0.007644237,
0.028332526,
-0.012489548,
0.01309026,
0.0039706463,
-0.0011593429,
0.00893808,
0.023500416,
0.01729525,
-0.0073669846,
-0.018760726,
-0.030920211,
-0.010509175,
0.005624257,
0.003924438,
0.012265106,
0.04634071,
-0.031527527,
0.017440477,
-0.0051588695,
-0.026418166,
0.003303921,
0.01707081,
0.023104344,
0.007868679,
-0.0061358535,
0.007941293,
0.0064626145,
0.027593186,
-0.013222286,
0.011803019,
0.023751264,
0.0016263807,
0.016569115,
-0.0041158735,
0.0085288035,
0.029731989,
0.009822646,
-0.0057232757,
-0.034062404,
-0.017466882,
-0.028121285,
0.04591823,
0.02070149,
-0.00058544753,
0.011109889,
-0.019222813,
0.0050037405,
-0.005079655,
-0.010997667,
0.015895788,
0.02042424,
-0.0033715838,
-0.0090569025,
0.000808652,
-0.011446551,
0.0038386215,
0.011215508,
0.016489899,
-0.02256304,
0.017546099,
0.000094892835,
0.00893808,
0.013889011,
0.031474717,
0.04074286,
0.015407296,
0.0004596114,
0.0152092585,
-0.00787528,
0.008020507,
-0.008317564,
-0.0004596114,
0.033217445,
-0.01255556,
0.020661883,
0.0067860754,
0.0068388856,
-0.001212978,
-0.012218896,
0.026774632,
-0.010515776,
0.034300048,
0.020226201,
0.01792897,
0.0078026666,
0.012172688,
-0.021150375,
0.02070149,
0.0011667693,
0.015196056,
-0.0045185494,
0.026404964,
0.0088390615,
-0.013889011,
-0.030444922,
0.014826387,
-0.009967874,
0.0075254147,
-0.023064736,
-0.0123509215,
-0.0015323131,
-0.015380891,
0.004967434,
-0.0003360444,
-0.021770893,
-0.015829775,
0.008132729,
-0.024926286,
-0.0077432552,
-0.016463494,
0.015420498,
-0.0032098533,
-0.0014696012,
-0.018681511,
0.04124455,
0.025850458,
0.016371077,
0.00026074902,
-0.0019556177,
0.007215156,
0.02377767,
-0.040716454,
-0.013057254,
-0.012647977,
-0.017136822,
0.009426571,
-0.011921841,
-0.017836552,
-0.017004797,
0.00032655513,
-0.0047000833,
0.0065154247,
-0.043119304,
0.009122915,
-0.00017627375,
0.02026581,
0.016397482,
0.014337895,
0.024873475,
-0.0037924128,
-0.00025579808,
0.0011147845,
-0.05175373,
0.011552172,
-0.008337367,
0.0016470096,
-0.00057802116,
-0.011142895,
-0.008627822,
0.007155745,
-0.008825859,
0.026193723,
-0.013327905,
0.015565726,
0.014707564,
0.025876865,
0.034564096,
0.0133015,
0.004198389,
0.027883641,
-0.0037924128,
0.016093826,
0.007710249,
0.039871495,
-0.015196056,
-0.024120934,
0.02463583,
0.01202086,
-0.023262773,
-0.031421907,
0.0030827795,
0.00941997,
0.037283808,
-0.00018803222,
-0.020279013,
-0.03952823,
-0.000093861396,
-0.015222461,
0.0029870614,
-0.011743607,
0.001585948,
-0.015869383,
0.0013417022,
-0.023209963,
-0.022866698,
0.068705715,
-0.038075957,
0.0022279187,
-0.006132553,
-0.039660256,
-0.0037924128,
-0.004208291,
0.0065088235,
-0.023289178,
-0.0012063767,
-0.03469612,
-0.025863662,
-0.02474145,
-0.0013639814,
0.016899176,
0.014932007,
0.010245126,
0.016133433,
0.008132729,
0.031105047,
-0.0035250627,
-0.00462747,
0.002411103,
-0.0053007966,
-0.011030673,
0.03522422,
0.005469128,
0.004861814,
0.015248866,
0.0046802796,
0.014377503,
0.016885974,
-0.033270255,
-0.019552875,
-0.010073493,
-0.03218765,
0.02059587,
-0.0045284512,
-0.009604805,
0.01893236,
-0.060572986,
-0.016885974,
0.006885094,
-0.00893808,
0.003239559,
-0.022549838,
0.0108590415,
-0.022100953,
0.013704176,
-0.002260925,
0.004409629,
0.001680841,
-0.009446376,
0.009116313,
0.0064626145,
-0.00096955727,
0.0059279143,
0.024200149,
0.0013705826,
-0.00017565489,
-0.020041367,
0.01399463,
-0.029573558,
0.008614619,
-0.017862957,
-0.006713462,
0.0026553492,
0.009076706,
-0.017150024,
-0.012251903,
-0.008700435,
0.0154865105,
-0.021137172,
0.020754302,
-0.014060643,
-0.0010661004,
-0.026814241,
-0.02037143,
0.013420323,
0.0019061082,
0.048162654,
0.010740219,
-0.013822998,
0.0017278747,
-0.016159838,
0.008660828,
0.02697267,
0.01654271,
-0.019302027,
-0.020886326,
-0.031105047,
0.0060731415,
0.037970338,
-0.03841922,
-0.014232275,
0.03781191,
0.003660388,
-0.014971614,
0.010522378,
-0.009862253,
-0.01952647,
-0.0038980327,
-0.022576243,
-0.0031801478,
0.008396778,
-0.01218589,
-0.0030349204,
0.023025127,
-0.022708269,
0.037415832,
0.00082226703,
-0.015050829,
-0.010225322,
-0.0053371033,
-0.0055714473,
0.006634247,
0.0055945516,
0.025718434,
-0.0191568,
0.006964309,
0.021520045,
-0.007215156,
0.013440127,
0.018206222,
-0.0080007035,
0.03345509,
0.007842274,
-0.0017377767,
0.037415832,
-0.016687937,
0.0054394226,
0.0024655634,
-0.018325044,
-0.035039388,
0.023645645,
0.0095784,
0.013651366,
0.0035976763,
-0.024952691,
-0.003914536,
-0.030101659,
0.0006394952,
-0.023830479,
-0.017057607,
-0.017044405,
-0.018694714,
-0.026312545,
-0.020041367,
-0.011519165,
0.0034821546,
-0.005208379,
-0.021005148,
0.0079809,
0.022048144,
-0.0058024907,
0.03717819,
-0.0150244245,
-0.00035151606,
-0.015420498,
0.022734674,
-0.042459182,
-0.0022361702,
-0.0038716276,
-0.0077432552,
-0.021572854,
-0.011413545,
0.014113453,
0.011505962,
-0.008225146,
0.0004315561,
0.022074549,
-0.0031900497,
0.01659552,
-0.006076442,
0.0014332944,
0.0060302336,
0.0098028425,
-0.009934868,
0.034115214,
-0.017018,
0.016740747,
-0.04383224,
0.014073845,
0.017242441,
-0.007644237,
-0.028755005,
-0.014522729,
0.02265546,
-0.017216036,
-0.015235663,
-0.020886326,
-0.012001056,
-0.032953393,
0.03414162,
0.011717202,
-0.01000088,
-0.0010974563,
0.019605685,
0.012687584,
-0.0037957134,
-0.021467235,
0.009783039,
0.012522554,
0.0077432552,
-0.017480087,
-0.0025348766,
0.003973947,
0.036095586,
0.033587113,
-0.027725212,
-0.012984641,
0.005558245,
-0.043383356,
-0.023394797,
-0.010925054,
0.004587862,
0.013756986,
-0.013572151,
0.007492408,
-0.009756634,
0.0034458477,
0.02070149,
-0.029758394,
-0.0075782244,
0.0033715838,
-0.029019054,
0.02581085,
0.0056374595,
-0.032161247,
-0.0122585045,
0.016687937,
-0.011288121,
0.010423359,
0.010674207,
-0.00308608,
0.031342693,
-0.021586057,
0.013545746,
0.003203252,
-0.020279013,
0.008277956,
-0.019170003,
0.02186331,
0.015671346,
0.017902564,
-0.00712934,
-0.014007833,
0.008106324,
-0.0037495047,
-0.021955727,
-0.040716454,
-0.030075254,
0.0029969632,
-0.015763763,
-0.0019869735,
0.0034821546,
-0.01819302,
0.020239403,
0.0028847423,
0.004119174,
-0.0057397787,
0.007710249,
0.00092912465,
-0.009485983,
0.0044855434,
-0.0100206835,
-0.042908065,
-0.005452625,
0.032002814,
-0.010964661,
0.0016816661,
-0.0069775116,
-0.034933764,
-0.017414073,
0.012832812,
-0.0005825595,
-0.011433349,
-0.005172072,
0.0022741274,
-0.017110417,
0.013413722,
-0.0075188135,
-0.000036384183,
0.008971087,
-0.007835673,
0.015077234,
-0.016265457,
-0.009452977,
-0.014522729,
-0.0052116797,
-0.0017212735,
0.042274345,
0.18578532,
0.012522554,
-0.009373762,
0.015473308,
-0.0015438652,
-0.0018846543,
0.014786779,
0.008812657,
-0.0002739515,
0.002940853,
0.013941821,
-0.0053206002,
0.0004061826,
-0.0010793029,
0.025863662,
-0.024239756,
-0.019407649,
-0.013638164,
0.015103639,
-0.02409453,
0.005852,
0.0054724286,
0.010819433,
-0.017044405,
0.02330238,
-0.0062018656,
-0.0059411167,
0.011776614,
0.04797782,
-0.0050565503,
-0.012641376,
0.0058652023,
0.0025183733,
0.0004992188,
0.03261013,
-0.007624433,
0.009287946,
-0.0049938387,
-0.010311138,
-0.021480437,
-0.019830128,
0.007862078,
-0.012370725,
0.016819961,
-0.01761211,
0.025441183,
0.0016494851,
-0.030022442,
0.00973683,
-0.021797298,
-0.027038682,
0.0044723405,
0.005406416,
0.0072613647,
-0.0061259517,
0.0038056152,
0.024530211,
-0.0056110546,
-0.016780354,
0.0043007084,
-0.008548607,
-0.00009809031,
-0.020714693,
0.031052237,
-0.01712362,
0.012780002,
-0.008812657,
-0.008429784,
-0.03527703,
0.01399463,
-0.0066804555,
-0.032847773,
-0.0027741715,
0.006677155,
-0.021255996,
0.006696959,
0.017202834,
0.017638516,
0.004337015,
0.0055945516,
0.017493289,
-0.022919508,
-0.007967697,
-0.017572504,
-0.011129692,
-0.040241163,
-0.0017922369,
0.024503807,
-0.016291862,
-0.0036471856,
0.011090085,
-0.02175769,
-0.03255732,
-0.012641376,
0.008198741,
-0.016463494,
-0.02851736,
0.011486159,
-0.017150024,
0.015011221,
-0.0010570236,
0.07868679,
0.0058453986,
-0.007954495,
0.0005648187,
-0.014007833,
0.0043271133,
0.023500416,
0.012964837,
0.0017740835,
-0.0011791467,
-0.021533247,
-0.012014259,
-0.017810147,
-0.0255336,
0.027461162,
0.022219777,
-0.01462835,
-0.00574638,
-0.009783039,
-0.021414425,
0.007485807,
0.017480087,
0.033877566,
0.011704,
-0.021850107,
-0.0025629317,
0.01878713,
-0.022034941,
-0.019275622,
0.014337895,
-0.023077939,
0.0029193987,
-0.009822646,
0.020635478,
-0.015473308,
-0.0036405844,
-0.008225146,
0.008542006,
0.03638604,
-0.0019539674,
-0.032636534,
0.019539673,
0.025560005,
0.015644941,
-0.0012666131,
-0.008905074,
0.009915064,
-0.005139066,
0.013360911,
0.0007995753,
-0.004832108,
0.014694362,
-0.008707036,
0.031474717,
-0.023592835,
-0.01787616,
-0.007419795,
0.02293271,
-0.0037164986,
-0.01952647,
0.013070457,
0.010311138,
0.0048387097,
0.009551995,
-0.01659552,
-0.16656251,
0.0324517,
0.019830128,
-0.033217445,
0.0038122165,
0.011255115,
0.025322359,
0.00718215,
-0.030946616,
0.00055863,
0.03464331,
-0.0070765303,
0.006320688,
-0.019935748,
0.007881882,
0.0041455794,
0.0017757338,
0.013024248,
0.024701843,
0.0015050829,
0.009393565,
-0.0012096774,
0.01766492,
-0.014826387,
0.006561633,
0.016859569,
0.003633983,
0.026206926,
0.003308872,
0.0038584252,
-0.017862957,
0.027276328,
0.020028165,
0.010060291,
-0.012595167,
0.0019589183,
0.0015776965,
-0.032055624,
0.0012905425,
0.0024226555,
0.011096686,
0.00019979068,
0.0017377767,
-0.005624257,
-0.010964661,
0.013849403,
-0.013585353,
-0.00648902,
0.00856181,
-0.009281345,
0.001622255,
-0.024279363,
0.034458477,
-0.0025579808,
0.011380539,
-0.00787528,
-0.015050829,
0.0074065924,
0.005670466,
-0.013228887,
0.002595938,
-0.018272234,
0.020279013,
0.03390397,
0.032953393,
-0.016080623,
0.007934691,
0.008304361,
-0.028332526,
0.01782335,
-0.028860625,
-0.03329666,
0.008687233,
-0.024662236,
0.036042776,
0.006911499,
-0.018285437,
0.010627998,
0.00077152,
-0.001010815,
-0.027117897,
0.0032494608,
-0.02298552,
-0.049298067,
-0.010106499,
0.0019655195,
0.007809268,
0.015367689,
-0.009142718,
-0.011472956,
0.02563922,
-0.031131452,
-0.01186243,
-0.024609426,
0.00141019,
-0.021744488,
-0.0013433525,
-0.0073075737,
-0.0052149803,
-0.022246182,
0.015829775,
-0.010991066,
-0.003261013,
0.02031862,
0.018021388,
-0.018681511,
0.009532192,
0.006779474,
0.042644016,
-0.02335519,
-0.0033765347,
-0.0046967827,
0.012357523,
0.0356467,
0.008878669,
0.029019054,
0.011340932,
-0.018971967,
0.0035712712,
-0.025203537,
0.061417945,
0.0110768825,
-0.0045845616,
0.029731989,
0.006409805,
-0.013651366,
-0.11364696,
-0.030075254,
-0.00009478969,
0.011406944,
0.02112397,
0.026616203,
-0.0005169597,
0.01771773,
0.0038023146,
0.008951282,
0.004102671,
-0.012489548,
0.0055615455,
0.010304537,
0.028860625,
-0.009287946,
-0.009934868,
0.0019820225,
-0.041455794,
0.043541785,
-0.02404172,
-0.009301148,
-0.010119702,
-0.028174095,
-0.0012402082,
0.0016874422,
-0.007835673,
-0.009446376,
0.0013747084,
-0.020028165,
0.0131892795,
0.019539673,
-0.008324165,
-0.00601043,
-0.012146283,
-0.023843681,
-0.009783039,
-0.003234608,
0.023856884,
-0.009433174,
0.01575056,
0.009763235,
0.03474893,
-0.0010174162,
-0.004449236,
-0.0055087353,
-0.04829468,
0.012945034,
0.021150375,
-0.03276856,
-0.034775335,
-0.019790519,
0.00044269572,
0.026140913,
0.019658495,
-0.013598556,
0.0143643,
0.021348413,
-0.020226201,
0.0044855434,
0.0028979448,
0.0005268615,
-0.008555208,
-0.0018202922,
0.006033534,
-0.024200149,
-0.020358227,
-0.025837256,
0.005347005,
-0.018008186,
-0.0070369225,
-0.0050763544,
-0.0015603683,
0.009380363,
-0.000015200904,
0.0276724,
-0.019341636,
-0.0103309415,
0.008865466,
-0.022959115,
-0.023526823,
-0.00654513,
0.02505831,
-0.010878845,
-0.000797925,
0.011519165,
0.0043271133,
-0.026484178,
-0.0071887514,
-0.0028764906,
-0.008634423,
0.026801039,
0.0031009328,
-0.025401575,
0.005323901,
0.0122321,
-0.006043436,
-0.018377854,
0.017638516,
0.01335431,
-0.012621572,
-0.0255336,
-0.04436034,
0.016252255,
0.017862957,
0.02112397,
-0.017836552,
-0.012674382,
0.0048750164,
0.023183558,
0.003878229,
-0.026299343,
-0.036148395,
-0.01462835,
-0.006624345,
-0.013215684,
-0.023223165,
-0.00074965344,
0.024622628,
0.008687233,
0.014667957,
0.0016470096,
-0.021665273,
-0.0011420146,
-0.006990714,
0.024609426,
0.01446992,
0.017414073,
-0.018470272,
-0.0029458038,
-0.021467235,
0.014337895,
0.011968049,
-0.02967918,
-0.009532192,
0.012885622,
-0.02431897,
-0.011321128,
-0.011505962,
0.018971967,
0.0059114113,
-0.0041356776,
-0.0089314785,
-0.007954495,
-0.016357874,
-0.0020579367,
0.0009060203,
0.012159485,
-0.037706286,
0.010753421,
-0.011921841,
-0.023553228,
0.0098952595,
0.010106499,
0.010172512,
-0.025124323,
-0.033824757,
0.0073603834,
-0.014285085,
0.012951635,
-0.003940941,
-0.0036240811,
0.019856533,
-0.0059675216,
-0.014456717,
-0.0046406724,
0.026418166,
-0.010132905,
0.009208731,
-0.00080741424,
0.0136249615,
0.006825683,
-0.00020505104,
-0.007591427,
-0.008601417,
0.0047892,
-0.0074131936,
0.025493992,
0.023091141,
0.033270255,
-0.018153412,
0.007069929,
-0.0059345155,
0.0071227388,
-0.036940545,
0.0054163183,
0.014694362,
-0.0059939264,
-0.004729789,
-0.0032956696,
0.012337719,
0.015948597,
0.013889011,
0.0063305898,
0.0065154247,
0.00012377326,
0.02930951,
0.023751264,
-0.00065311027,
-0.0005545042,
0.009136117,
0.027725212,
0.024503807,
0.022708269,
-0.006432909,
-0.030497732,
0.014905602,
0.0029028957,
-0.015275272,
-0.02676143,
-0.017862957,
-0.009763235,
0.013420323,
0.025018703,
0.00154304,
0.0028962945,
-0.0070303213,
0.01633147,
-0.00941997,
-0.013083659,
-0.020411037,
0.02563922,
0.00018328757,
0.005597852,
0.008865466,
-0.0058652023,
0.033639923,
-0.0062744794,
0.051489677,
-0.024028517,
0.017110417,
-0.00803371,
0.024305768,
0.016621925,
-0.040716454,
-0.009717027,
0.004911323,
-0.039132155,
0.0014836289,
0.025916472,
0.013136469,
0.061734803,
-0.0009200479,
-0.02590327,
0.0025926374,
0.010680808,
0.0114795575,
0.0070765303,
0.008997492,
-0.0239493,
0.0032940193,
-0.0030778286,
-0.015552524,
0.011710601,
-0.021242794,
-0.027936451,
0.04153501,
0.012793205,
0.0069379043,
0.0076640407,
-0.020252606,
0.016199445,
-0.005597852,
0.017255643,
0.004868415,
-0.018060995,
-0.01000088,
0.03612199,
-0.0024226555,
-0.01782335,
0.00867403,
-0.005307398,
0.013638164,
-0.031263478,
-0.013585353,
0.023962503,
-0.015975002,
-0.018773928,
-0.0075254147,
0.00027085716,
-0.023922896,
-0.0011477907,
-0.006320688,
-0.02563922,
-0.011149496,
-0.010872244,
-0.02144083,
-0.012265106,
0.015407296,
-0.02804207
] |
Stress-induced immunological reactions to exercise have stimulated much research into stress immunology and neuroimmunology. It is suggested that exercise can be employed as a model of temporary immunosuppression that occurs after severe physical stress. The exercise-stress model can be easily manipulated experimentally and allows for the study of interactions between the nervous, the endocrine, and the immune systems. This review focuses on mechanisms underlying exercise-induced immune changes such as neuroendocrinological factors including catecholamines, growth hormone, cortisol, beta-endorphin, and sex steroids. The contribution of a metabolic link between skeletal muscles and the lymphoid system | [
-0.032323923,
-0.0052361125,
0.017730203,
-0.03841544,
-0.033931047,
0.01209879,
-0.0021660528,
-0.023990208,
0.00653542,
-0.020387141,
-0.009552017,
-0.0039627263,
0.004941257,
0.013673512,
-0.0069793235,
-0.00022255909,
0.050261497,
0.00015562936,
-0.021618405,
-0.01478813,
-0.010336138,
0.0085216435,
0.008346675,
0.003340614,
-0.010634233,
0.00845036,
0.0014491654,
-0.050676238,
-0.009927877,
-0.008430919,
0.011839576,
-0.0068821185,
-0.02247381,
-0.0065840227,
-0.01248113,
-0.0070959693,
0.006778433,
-0.010115807,
0.01671927,
0.001402183,
0.00519075,
0.011003613,
-0.010893447,
0.0146455625,
0.011988624,
0.022590457,
0.025856547,
-0.03978927,
-0.0152547145,
0.041707452,
0.029187439,
0.009649223,
0.015397281,
0.021631366,
-0.029213361,
-0.0234329,
0.009247442,
0.0027201215,
0.020102007,
-0.034682766,
-0.03017245,
-0.008916944,
-0.011392433,
0.023575468,
0.0033470942,
0.003667871,
0.0018776777,
0.0055244877,
-0.023847641,
0.00025658085,
0.024275344,
0.035460405,
-0.020633394,
0.008022658,
0.018015338,
-0.008392037,
-0.011975664,
-0.008139304,
0.009856593,
0.0036225086,
0.009545537,
-0.03476053,
-0.01134059,
0.021164782,
0.017341383,
-0.010621273,
0.014373388,
-0.023718035,
0.009726986,
-0.014373388,
-0.0053721997,
0.005164829,
0.004899135,
0.0069598826,
-0.013738316,
0.017172894,
0.005355999,
0.033179328,
-0.011023054,
-0.019155877,
-0.0152547145,
-0.013712394,
-0.013226368,
-0.0135827875,
-0.04704725,
-0.0033665353,
0.0014718466,
0.0017999137,
0.0017675121,
-0.017769085,
-0.015293596,
0.007756964,
-0.017509872,
-0.053242452,
0.022253478,
0.00672659,
0.0025386722,
-0.0070959693,
-0.005427283,
-0.03361999,
0.016615584,
0.006072076,
0.021061096,
0.0020591272,
0.010912888,
0.0007634648,
-0.022318281,
-0.00027379426,
-0.012558894,
-0.0035415045,
-0.012455208,
0.004396909,
-0.00031530892,
0.0112045035,
-0.042381406,
0.0027752046,
-0.017017366,
-0.008191147,
-0.013764237,
-0.0018890183,
0.016939603,
0.01114618,
-0.01862449,
-0.0077828853,
0.0004876454,
0.034993824,
0.02882454,
0.019078113,
0.00010793812,
0.022616377,
-0.024158698,
-0.025675097,
-0.0035058626,
0.0035868667,
0.013867922,
0.008275391,
-0.01478813,
0.016097158,
-0.033749595,
-0.025065945,
0.036160283,
-0.021346232,
0.0047338866,
0.00063628814,
-0.016356371,
-0.0063442504,
0.011729411,
-0.004072892,
0.009163197,
-0.007510711,
0.0057545397,
0.031209305,
-0.02111294,
0.0075625535,
-0.008891023,
0.036186203,
0.0036354694,
0.0176654,
-0.008528124,
-0.016395254,
-0.003803958,
0.007718082,
0.02632313,
-0.0077699246,
0.002747663,
0.012163593,
0.019129956,
-0.029109675,
0.0023961049,
-0.0069080396,
-0.01824863,
0.009876034,
-0.027139653,
-0.021748012,
-0.6382873,
0.0005030362,
0.014827012,
-0.0015212592,
0.02631017,
0.02783953,
0.011625725,
-0.012500571,
-0.019285483,
0.01574722,
-0.00032988968,
0.02861717,
0.0122932,
-0.020607473,
0.005670295,
-0.03413842,
-0.011282267,
-0.030846406,
0.0303539,
-0.017315462,
-0.0054046013,
-0.001420814,
0.0058096224,
0.025078906,
0.021838738,
0.01151556,
0.00710893,
-0.01863745,
0.013971607,
0.033283014,
-0.0053948807,
0.026206484,
0.00519399,
0.025493648,
0.05453852,
0.005725378,
-0.016174922,
0.018507844,
0.0052879555,
0.025804704,
-0.019648382,
-0.007335742,
-0.0025629734,
0.0057545397,
0.0019133196,
0.025843585,
0.028487563,
0.0040404904,
0.03227208,
-0.018261591,
0.022020187,
0.016784074,
0.009117834,
0.008670691,
0.012973635,
0.0031980465,
0.013388377,
-0.002075328,
-0.001441065,
0.007024686,
0.023627311,
0.0342421,
-0.009292804,
-0.003881722,
-0.019052193,
0.026413856,
-0.020464905,
-0.021838738,
-0.0054499637,
-0.006068836,
0.023329215,
0.03133891,
-0.007957854,
-0.011826616,
0.03768964,
0.022110911,
-0.009999161,
0.00047670983,
-0.021851698,
0.0094353715,
-0.025428845,
0.017872771,
-0.004468193,
0.0076727197,
0.016861837,
-0.01018709,
-0.008165225,
0.012643138,
-0.018598568,
-0.015552809,
0.0076273573,
0.02305704,
-0.029083755,
-0.025286276,
-0.028072821,
0.010724958,
-0.007951374,
0.019739108,
0.030042844,
-0.00091291755,
0.0043515465,
0.017445069,
-0.0042024986,
0.0054823654,
0.001651676,
0.013161565,
-0.042199958,
0.0071542924,
0.068795264,
-0.014723327,
0.023873564,
0.02688044,
-0.022046108,
0.010718478,
-0.003168885,
-0.017509872,
0.015086225,
0.0012847269,
-0.0064058136,
-0.023212569,
0.02475489,
-0.013232849,
0.019648382,
-0.0034021772,
0.00787361,
0.018974427,
-0.011897899,
-0.02667307,
-0.008780858,
-0.025493648,
0.02461232,
-0.00043337257,
0.026932282,
0.00345726,
0.027813608,
-0.01036854,
0.016006432,
0.025869507,
-0.004451992,
-0.04144824,
-0.022771906,
-0.00441635,
-0.013414298,
0.00089185644,
-0.010251894,
-0.009007669,
-0.023005197,
0.0093835285,
0.034501318,
-0.00023673482,
0.0019360008,
0.0008473041,
-0.024029091,
0.0012158733,
0.013621669,
-0.009545537,
-0.012798666,
-0.024832653,
-0.0097399475,
0.0017772325,
0.00614336,
0.018339355,
-0.017134013,
0.042148113,
-0.029861394,
-0.011185062,
-0.027476631,
0.022525653,
-0.013174525,
-0.03940045,
0.008968787,
-0.02094445,
-0.027476631,
0.027580315,
0.014671484,
-0.009513135,
-0.009053031,
-0.015384321,
-0.018067181,
0.0021725332,
-0.010128767,
-0.028124664,
-0.015773142,
0.003748875,
0.011366512,
0.006315089,
0.021423995,
0.0108999275,
0.003784517,
0.02478081,
-0.0028076062,
0.0058679455,
-0.022396047,
-0.0053884005,
0.0011113778,
-0.024288304,
-0.0031219025,
-0.02095741,
0.019337326,
0.007834728,
0.0153584,
-0.024806732,
0.009811231,
-0.015034383,
0.012954194,
-0.011638686,
0.009351127,
-0.004283503,
0.019570619,
-0.01767836,
0.0022745985,
0.0044098697,
-0.011450756,
-0.015526888,
-0.010323177,
0.0030084967,
-0.0055018063,
0.008806778,
-0.006055875,
-0.0152028715,
0.016460057,
-0.011606284,
0.027035968,
-0.028746776,
-0.016382294,
0.047539756,
-0.0051227068,
-0.0012871571,
0.008605888,
-0.025130749,
0.013284692,
0.008275391,
-0.004001608,
0.008061539,
0.009655703,
0.014515956,
-0.019116996,
-0.009195599,
0.043314576,
0.014749248,
0.004208979,
0.004899135,
0.010012121,
-0.021385113,
0.016563741,
0.0019538216,
0.02633609,
-0.014075293,
-0.013427259,
0.015552809,
-0.014878855,
-0.010122287,
0.0023685633,
-0.004976899,
-0.012273759,
0.0022243757,
0.005242593,
-0.0010919368,
0.033308934,
0.029135596,
0.02783953,
-0.0052879555,
0.015837945,
-0.011496118,
0.012157113,
0.009623301,
0.0042122193,
-0.006279447,
-0.008398517,
-0.0052717547,
-0.0456475,
0.021048136,
0.00806802,
-0.004558917,
0.016952563,
0.018131984,
0.03346446,
0.002072088,
0.05057255,
0.0030522388,
-0.005456444,
-0.007802326,
0.0022195156,
0.0070765284,
0.021022214,
0.006642346,
-0.025182592,
-0.00172863,
-0.005411082,
0.002227616,
0.0024868294,
0.008528124,
-0.0071542924,
-0.011969184,
-0.02882454,
0.007659759,
0.021786895,
-0.007795846,
0.006606704,
-0.027632158,
0.006224364,
0.02633609,
-0.016395254,
0.0014353947,
0.012338562,
0.025493648,
-0.0015479906,
-0.013168045,
0.008813259,
-0.023562506,
0.008858621,
-0.0093316855,
0.00088618614,
-0.024625283,
0.006389613,
0.00057715503,
-0.0041214945,
-0.009111354,
0.019829832,
-0.011094337,
-0.007530152,
-0.039478216,
-0.017613556,
-0.034345787,
0.05202415,
-0.0061790016,
-0.004011329,
0.025104826,
-0.0019198,
-0.0044098697,
-0.0057188976,
-0.026828596,
0.035797384,
-0.012895871,
-0.021203663,
-0.010102846,
0.003862281,
0.017522832,
0.0036419495,
0.015138068,
0.018546725,
-0.02072412,
-0.01613604,
-0.004056691,
0.026076877,
-0.004403389,
0.021981305,
0.055575375,
0.035641856,
0.017626518,
-0.0085734865,
0.021735052,
-0.016615584,
-0.020114968,
0.008819739,
0.027347025,
0.006392853,
0.007510711,
-0.007199655,
-0.0011283888,
-0.009292804,
0.031572204,
0.014347467,
-0.016861837,
0.02633609,
0.022590457,
0.018300474,
0.022758946,
0.00044876337,
-0.012163593,
0.016615584,
0.001518829,
0.006642346,
-0.0047176857,
0.027243339,
-0.012889391,
-0.001095177,
-0.032946035,
0.0071413317,
0.001113808,
0.0045815986,
-0.023847641,
-0.010854566,
0.005336558,
-0.0070441267,
0.012500571,
-0.0013211787,
0.0052717547,
-0.03128707,
-0.016278608,
0.01018061,
0.013738316,
0.0029372128,
-0.025584372,
-0.0070570875,
-0.024482714,
-0.008683652,
0.010472225,
0.030224293,
0.018261591,
0.025830625,
-0.021229586,
0.0029274924,
0.0034637402,
-0.013284692,
0.004536236,
-0.009668663,
-0.033127483,
0.019920558,
0.007912492,
0.005799902,
-0.014477074,
-0.0037391547,
-0.0061919624,
-0.009098394,
-0.0053106365,
-0.012545933,
0.018067181,
0.005488846,
0.012364483,
0.013725354,
0.014347467,
0.0014491654,
-0.0066682673,
-0.014425231,
-0.029809551,
0.00017203271,
0.0096881045,
-0.014930697,
-0.022409007,
0.003151064,
0.005725378,
0.011735891,
-0.009552017,
0.03667871,
-0.01382904,
0.021631366,
0.005663815,
0.023342175,
0.019687265,
0.005647614,
-0.0043321056,
0.015695376,
-0.023756918,
0.0027023007,
-0.0029858155,
0.022927433,
-0.0021838737,
-0.018378237,
-0.014490034,
-0.005278235,
0.0012498951,
-0.012500571,
0.02111294,
-0.033749595,
0.019142916,
-0.0028011259,
-0.019091073,
-0.03517527,
-0.0059651504,
-0.02614168,
0.020996293,
0.019959439,
-0.021670248,
-0.021527681,
-0.008508683,
-0.02708781,
-0.0069663627,
0.052127834,
-0.03413842,
-0.012085829,
0.0068302755,
-0.015436164,
0.0030814004,
-0.015086225,
0.007581995,
-0.022033148,
0.016822957,
-0.015241753,
-0.04746199,
-0.00653218,
-0.0024106854,
0.019104034,
0.031209305,
0.029083755,
0.0038331195,
0.016213804,
0.03128707,
-0.020853726,
0.004623721,
-0.00040056586,
-0.0055601294,
-0.019777989,
-0.000047184956,
0.022745984,
0.00065451406,
0.013388377,
-0.017432107,
-0.0074847895,
0.02075004,
0.0024171658,
-0.030120607,
-0.015215832,
-0.04416998,
0.0035965873,
0.04323681,
0.006836756,
0.022784866,
-0.029213361,
-0.016797034,
0.0054726447,
0.01576018,
0.007089489,
-0.028150586,
-0.004166857,
-0.022020187,
0.010854566,
-0.011450756,
-0.00063021283,
-0.004549197,
-0.010258374,
0.0088262195,
-0.007607916,
0.009571458,
-0.015060304,
0.017030327,
-0.013142124,
0.021048136,
-0.014762209,
-0.006797874,
-0.020270495,
-0.00034791313,
-0.02401613,
-0.017833889,
-0.0041927784,
0.012753304,
-0.003321173,
-0.02843572,
-0.007283899,
0.007737523,
-0.019700225,
0.0043126647,
-0.016291568,
-0.00024868295,
0.011463717,
-0.013958647,
0.008275391,
-0.0053138766,
0.041422315,
0.016991444,
0.0001383147,
-0.015578731,
0.0024722486,
0.005997552,
0.015397281,
0.004636681,
-0.0117099695,
0.007160773,
-0.03131299,
0.0049995803,
0.009895476,
-0.019829832,
-0.014554838,
0.026932282,
0.03457908,
0.01478813,
-0.023095923,
-0.023264412,
-0.004685284,
0.01325229,
-0.0057966616,
-0.0041571367,
-0.010537028,
-0.012208955,
-0.008800298,
0.037171215,
-0.016758153,
0.026284248,
-0.0045394762,
-0.000825838,
-0.007977296,
-0.014749248,
-0.004711205,
0.0050643836,
0.0075171916,
0.031209305,
-0.00960386,
0.011295228,
0.018274551,
-0.001955442,
0.02075004,
0.01862449,
-0.0061757616,
0.034734607,
-0.0027023007,
-0.00058525545,
-0.008696613,
-0.012072869,
0.010848084,
-0.021411035,
-0.0025613534,
0.005414322,
-0.003590107,
0.025519568,
0.0032158673,
0.013362456,
-0.022797827,
-0.00940945,
-0.034112494,
0.0019311405,
-0.012552413,
-0.008793818,
-0.01478813,
-0.014969579,
-0.0038687615,
-0.012221917,
0.008916944,
0.0069987644,
0.00863181,
-0.012973635,
0.011664608,
0.019285483,
-0.017898692,
0.012183034,
0.017380266,
0.024521597,
-0.01286995,
0.022396047,
-0.028876383,
-0.019428052,
0.014801091,
-0.016680388,
-0.04266654,
-0.022201637,
0.005994312,
0.019415092,
0.0069080396,
0.004455232,
0.032012865,
-0.017172894,
0.0043677473,
-0.0018063941,
-0.026750833,
0.022577496,
-0.0022340964,
-0.011839576,
0.03017245,
-0.0284098,
0.007530152,
-0.0042737825,
0.027010046,
0.012759784,
-0.003515583,
-0.010744399,
-0.03170181,
-0.002861069,
-0.0060299537,
-0.0058906265,
-0.00480517,
-0.0018193547,
-0.011081377,
0.021838738,
-0.0005836354,
0.011042495,
-0.011385953,
-0.0045945593,
0.030276136,
0.009104874,
-0.01748395,
0.026932282,
0.008353155,
-0.013660551,
-0.039270844,
0.0008043719,
0.010005641,
0.025454765,
0.022551574,
0.007374624,
-0.040411383,
0.01844304,
-0.041396394,
0.015280636,
0.020218652,
0.002284319,
0.010167649,
0.023562506,
-0.013647591,
-0.0037359146,
0.0115090795,
0.009526096,
-0.017989416,
-0.020685237,
0.004144176,
-0.0020477867,
0.0025483926,
0.02075004,
-0.0057156575,
0.009513135,
0.024093894,
-0.010776801,
0.007257978,
0.0050805844,
-0.0004957458,
-0.0037391547,
-0.010349099,
0.009124315,
0.00062656763,
0.005644374,
0.011094337,
-0.01323933,
-0.014710366,
0.021294389,
-0.020127928,
-0.0017221497,
0.005803142,
0.0036063078,
0.009091914,
-0.0002648838,
-0.02075004,
-0.00672659,
0.019998321,
-0.029628102,
0.021760972,
0.02476785,
-0.011794214,
0.012545933,
-0.031416677,
-0.031598125,
-0.02303112,
-0.020711157,
-0.02516963,
0.012558894,
0.01326525,
-0.009040071,
-0.020763,
0.020218652,
0.027347025,
-0.019259563,
0.01345318,
-0.014101214,
0.014010489,
-0.0040080887,
0.018598568,
0.011774773,
-0.007504231,
-0.003859041,
0.0012636657,
-0.005505047,
-0.013187487,
-0.004545957,
-0.011379473,
0.0025807943,
-0.013323573,
0.005038462,
-0.025040023,
-0.010005641,
-0.02058155,
0.0077893655,
-0.022979276,
0.011735891,
0.19098851,
-0.032764588,
-0.01706921,
0.014282663,
0.0014815672,
-0.032971956,
-0.0012134432,
0.002916152,
-0.013271731,
-0.0059262686,
0.014865894,
0.0109517705,
-0.02016681,
0.0068821185,
0.00557309,
-0.017004406,
-0.035019744,
0.011781253,
0.00088942633,
0.0033470942,
0.013323573,
0.012720902,
0.0052328724,
-0.004954218,
0.0399448,
0.0010846464,
-0.009364087,
0.029654024,
0.019855754,
-0.016498938,
-0.009202079,
0.011580363,
-0.012241357,
0.012921792,
-0.010511107,
0.008884543,
-0.005508287,
-0.017496912,
-0.004396909,
-0.003398937,
-0.004393669,
-0.015902748,
-0.0122932,
0.013323573,
0.0067330706,
0.00037727715,
-0.015060304,
-0.017626518,
-0.0048472923,
-0.021916501,
-0.060137533,
-0.013161565,
-0.014878855,
0.016602624,
0.03346446,
0.00902711,
0.010459265,
0.010076924,
0.021190703,
0.022616377,
-0.02592135,
-0.0035706658,
-0.03172773,
0.031468518,
-0.0146455625,
0.007906011,
-0.0070959693,
-0.0030295576,
-0.019557659,
-0.0042899833,
-0.01056295,
-0.0013114583,
-0.007160773,
0.012332082,
-0.019713186,
0.016226765,
0.028954148,
0.0040048487,
-0.012759784,
-0.002397725,
-0.008968787,
0.024055012,
-0.024106855,
0.01959654,
0.0036484299,
-0.012643138,
0.03457908,
-0.0048894146,
-0.04575118,
0.022603417,
-0.0018144945,
-0.009707546,
-0.015034383,
-0.008741975,
0.007452388,
-0.012591296,
0.024353107,
0.009441852,
-0.016589664,
0.0176654,
-0.029213361,
0.0898434,
-0.003306592,
0.014425231,
0.0018063941,
0.0066941883,
0.010867526,
0.020270495,
0.0012831069,
0.012429287,
0.008800298,
-0.01824863,
0.003512343,
-0.015306557,
-0.010575911,
0.013945686,
0.0071542924,
-0.008560525,
0.017989416,
-0.008009697,
-0.001614414,
0.009059512,
0.011010094,
0.00085945474,
0.020400101,
0.005093545,
-0.033153407,
0.00691452,
0.011677568,
-0.017393226,
0.0034929018,
-0.013375416,
0.0068821185,
0.014075293,
0.01691368,
-0.0014329646,
0.023925405,
-0.02286263,
0.0095909,
0.019777989,
-0.005968391,
-0.031805497,
0.009247442,
-0.005031982,
0.01132115,
-0.0036160282,
-0.014930697,
0.018015338,
-0.03014653,
-0.002397725,
0.00069987646,
-0.015397281,
-0.007452388,
-0.013699433,
0.013284692,
-0.020192731,
-0.027787687,
-0.031909183,
-0.020011282,
0.002285939,
-0.020879647,
0.024677124,
-0.005171309,
-0.005433763,
-0.019505816,
-0.004941257,
-0.16029763,
0.01018061,
0.038104385,
-0.006626145,
0.027321102,
0.0026958203,
0.0007537442,
0.004079372,
-0.019350287,
0.013712394,
0.032012865,
0.00039084535,
-0.023627311,
-0.005498566,
0.010096366,
0.010407422,
0.0066617867,
0.0070441267,
0.018365277,
0.011113779,
-0.0028108463,
-0.02879862,
0.015734259,
-0.019376209,
-0.0093316855,
0.01940213,
0.0073875845,
0.0030214572,
0.015682416,
-0.018144945,
-0.03131299,
-0.0024835893,
-0.0014945278,
0.0009939218,
-0.0036160282,
0.011729411,
0.030561272,
-0.025014102,
-0.008022658,
0.013284692,
0.037560035,
0.0036257487,
-0.0076921606,
0.010906408,
-0.0041150143,
0.0049088555,
-0.0027881651,
0.014671484,
0.009053031,
-0.005910068,
0.0065743024,
0.003901163,
0.00003817324,
0.0048310915,
0.022577496,
-0.0035317838,
0.016758153,
-0.00518103,
0.0070959693,
-0.008139304,
-0.0010287536,
-0.021968344,
0.037015688,
0.0040210495,
0.009085433,
-0.009681624,
0.021203663,
0.038182147,
-0.03361999,
0.0074588684,
-0.008897503,
-0.013414298,
-0.004056691,
-0.0071931747,
0.019920558,
0.011573883,
-0.00863829,
-0.004954218,
-0.019285483,
0.016473018,
0.0074459077,
0.0141400965,
-0.01706921,
-0.023082962,
-0.017600596,
0.019985361,
0.016149001,
0.02130735,
-0.008307792,
0.0011543101,
0.020827804,
-0.04147416,
-0.0068821185,
-0.012604256,
-0.008379077,
0.003765076,
0.012798666,
0.00035803864,
0.023795798,
0.0123191215,
0.014684444,
-0.017937575,
-0.0135309445,
-0.0012920173,
0.0058063823,
-0.031909183,
-0.0026925802,
-0.011820136,
0.027450709,
-0.0058744256,
-0.014606681,
0.013984568,
-0.007199655,
0.022007225,
0.00015542684,
0.047254622,
0.017509872,
-0.014801091,
-0.021540642,
-0.016602624,
0.071335554,
0.0070700482,
-0.021838738,
-0.01307084,
0.0043677473,
-0.023912445,
-0.13665736,
-0.05479773,
0.004147416,
-0.0056314133,
0.031364832,
0.029628102,
-0.0059521897,
0.03724898,
-0.0188189,
0.02286263,
-0.0030846405,
0.016434135,
-0.006895079,
-0.0015625714,
0.0038882024,
0.00038902275,
-0.0041150143,
-0.016382294,
-0.018183827,
0.022421967,
-0.007050607,
-0.01900035,
-0.020516748,
-0.001421624,
0.0028967108,
0.01920772,
0.004302944,
0.008398517,
0.018780017,
0.015617613,
0.014425231,
0.004941257,
0.013517984,
-0.015604652,
0.0017334903,
0.021799855,
-0.020646354,
-0.019272523,
0.028772699,
0.003154304,
-0.005673535,
-0.0028464883,
0.020011282,
-0.0051486283,
0.0011875218,
-0.016304528,
-0.043781158,
0.00017223522,
0.019881675,
-0.01421786,
-0.023951327,
-0.04282207,
-0.02708781,
0.006477097,
0.030094687,
0.029239282,
0.027398866,
0.038700573,
-0.0118136555,
0.0005443483,
0.03455316,
-0.0025775542,
0.0021449917,
-0.008003216,
0.019777989,
-0.03152036,
-0.014554838,
-0.0057772207,
0.004857013,
-0.007795846,
-0.0009445092,
-0.021099979,
-0.019816872,
0.0060785566,
-0.008100422,
0.010543509,
-0.008579967,
-0.03903755,
0.0018225949,
-0.008126343,
-0.0062600058,
-0.009564978,
-0.005323597,
-0.020853726,
0.02825427,
0.01209231,
0.011100818,
-0.01844304,
-0.011535001,
0.018663371,
-0.030820485,
0.023355136,
0.021735052,
-0.024858573,
-0.0035415045,
-0.0066617867,
-0.020218652,
-0.02016681,
0.014243782,
0.021164782,
0.0135827875,
-0.025260355,
-0.027684001,
0.014360428,
-0.0013754516,
0.009169677,
0.008476282,
-0.009253922,
0.0022632577,
-0.020866686,
0.02457344,
-0.015241753,
-0.03971151,
-0.005038462,
0.006062356,
0.010621273,
-0.022318281,
-0.025882468,
0.01209231,
-0.011178582,
0.0006990664,
0.02287559,
-0.0059586703,
0.011016574,
0.022525653,
0.023938367,
0.009117834,
-0.0046204804,
-0.007893051,
0.0022697381,
-0.027061889,
-0.024353107,
-0.0053106365,
-0.03017245,
-0.042899832,
0.005281475,
-0.02765808,
-0.020827804,
0.020296417,
0.03281643,
0.01036206,
0.031416677,
-0.011535001,
-0.04572526,
-0.014477074,
-0.025312198,
-0.018417118,
-0.0019862235,
-0.039504137,
0.025571411,
-0.020011282,
-0.030068766,
0.038467284,
0.021605445,
0.0041603767,
-0.033153407,
-0.010582391,
0.03128707,
0.0034118977,
0.009539057,
-0.021773934,
0.00576102,
-0.001229644,
-0.0054499637,
-0.008340194,
0.0009842012,
0.019622462,
0.005200471,
-0.034293946,
-0.010835124,
0.018909624,
0.015902748,
-0.009091914,
0.027761765,
-0.0047695283,
-0.016343411,
0.0020818084,
0.0017513111,
0.010407422,
0.006434975,
-0.010867526,
0.009746428,
0.008534605,
-0.0034410593,
-0.009778829,
0.014256742,
0.04764344,
0.012124712,
-0.019233642,
0.025195552,
0.017406186,
-0.0053884005,
0.009137276,
-0.0061822417,
-0.013842001,
0.016071238,
0.023549546,
0.02305704,
0.008217067,
0.004954218,
0.019104034,
0.025104826,
0.03452724,
-0.002805986,
0.017717242,
-0.027035968,
-0.01843008,
0.0021028696,
-0.036549103,
-0.018404158,
-0.030276136,
-0.0024042053,
-0.002728222,
0.019428052,
0.010809203,
-0.0035026222,
-0.022331243,
0.025752861,
-0.024249423,
0.020153848,
-0.0045265155,
0.00518427,
0.008048579,
0.0069015594,
-0.029550338,
-0.0059521897,
0.021372152,
0.006065596,
0.0021628125,
-0.029213361,
0.008353155,
0.017159933,
0.026362013,
-0.012202475,
-0.031935103,
-0.022201637,
-0.018300474,
-0.034993824,
0.002039686,
0.011126739,
-0.018961467,
0.04958754,
0.015708338,
0.0034086574,
-0.0026553182,
0.005346278,
0.00865125,
-0.0031737452,
0.015721299,
-0.038156226,
-0.019920558,
0.005511527,
-0.0012968775,
0.0038558007,
-0.046813957,
-0.027709922,
0.03053535,
-0.02879862,
0.017704282,
0.0008797058,
-0.020594513,
0.0039497656,
-0.008392037,
0.01940213,
0.008139304,
-0.026802676,
0.0076532783,
0.025130749,
-0.031235225,
0.0031462037,
-0.003207767,
0.008314273,
0.013932725,
-0.048939507,
-0.01441227,
0.00556985,
-0.022421967,
-0.012131192,
0.005051423,
-0.0058711856,
0.005903587,
-0.0051389076,
0.010232452,
-0.034345787,
-0.011236905,
-0.013816079,
-0.008074501,
-0.026076877,
0.009091914,
-0.016317489
] |
Regulatory gene circuits with positive-feedback loops control stem cell differentiation, but several mechanisms can contribute to positive feedback. Here, we dissect feedback mechanisms through which the transcription factor PU.1 controls lymphoid and myeloid differentiation. Quantitative live-cell imaging revealed that developing B cells decrease PU.1 levels by reducing PU.1 transcription, whereas developing macrophages increase PU.1 levels by lengthening their cell cycles, which causes stable PU.1 accumulation. Exogenous PU.1 expression in progenitors increases endogenous PU.1 levels by inducing cell cycle lengthening, implying positive feedback between a regulatory factor and the cell cycle. Mathematical | [
-0.019201942,
-0.0036204779,
0.004693212,
-0.025303118,
-0.020489223,
-0.007200728,
-0.012778946,
0.015273053,
-0.032074753,
-0.031672478,
0.012866106,
-0.0023868335,
-0.0014850664,
0.018719211,
-0.014602594,
-0.007220842,
0.036177963,
-0.0032718393,
-0.0019728253,
0.016292151,
-0.034139767,
0.02283583,
-0.029205188,
-0.030304741,
-0.0309752,
0.016613971,
0.005957027,
-0.046556663,
-0.006741464,
-0.020985363,
0.022902876,
0.017525796,
0.00041652258,
0.01566192,
0.0026047328,
-0.0125442855,
0.010848025,
-0.016868746,
0.0153669175,
-0.005879924,
0.035668414,
0.038028426,
-0.012001214,
-0.0032249072,
-0.01940308,
-0.006352598,
0.015527828,
0.002197429,
-0.008816535,
0.037679788,
0.0032969816,
-0.00036058118,
0.0017281078,
0.0006901536,
-0.036419325,
0.0072610695,
0.030546106,
0.022715148,
-0.004673098,
-0.0024505272,
-0.005591627,
-0.005645264,
-0.0118067805,
-0.009232218,
-0.008789716,
0.025034934,
0.0132952,
0.011927463,
0.01182019,
-0.0009461851,
0.018182844,
0.02136082,
-0.0060207206,
0.004233948,
-0.00022271805,
-0.012001214,
-0.019858992,
0.0155144185,
0.0011196664,
0.00501168,
0.0062151537,
-0.010251316,
-0.014133274,
0.019966265,
0.0012747099,
-0.018866712,
-0.0060073114,
0.024149928,
0.015594874,
-0.024310838,
0.022755375,
0.029124733,
0.040683445,
0.0108212065,
-0.0049580433,
-0.004726735,
0.0063358364,
0.023814699,
0.00067003985,
-0.013194631,
-0.017177157,
0.00019967103,
-0.013489633,
-0.018987395,
-0.035668414,
-0.0114447335,
0.0029366098,
-0.018021936,
0.03226248,
-0.0032517256,
-0.05363671,
0.026228352,
-0.021347411,
-0.0397448,
0.04518893,
0.00014666287,
-0.0061346986,
0.010566432,
-0.022648102,
0.002254418,
0.023881745,
0.026509944,
0.023144241,
-0.02315765,
0.026818356,
0.013201335,
0.010667001,
0.013798044,
-0.027596088,
0.0069392496,
0.0007496568,
0.0011246948,
0.0037780358,
0.028642002,
-0.020650133,
-0.01795489,
-0.010009951,
-0.01247724,
0.005363671,
-0.025638347,
0.0074286843,
0.04760258,
-0.016332379,
0.003838377,
0.005910095,
0.02267492,
0.011940872,
0.0032031173,
-0.0010945242,
-0.010016656,
-0.000569471,
-0.015286462,
0.022232417,
0.007167205,
0.0053435573,
-0.0016132917,
0.0119542815,
0.030465651,
-0.013161108,
-0.0056720823,
0.0139053175,
-0.015769193,
0.017874435,
0.018598529,
0.018075572,
0.027126767,
-0.00038111396,
0.008943922,
0.0077706184,
-0.0044317334,
-0.0038752523,
0.00872267,
-0.028642002,
0.010190975,
0.0011665984,
0.0119542815,
-0.010740751,
0.011739735,
-0.025785848,
-0.009808813,
0.0057625943,
-0.010211089,
0.023278331,
0.009815518,
-0.020153994,
-0.021065818,
0.02055627,
-0.030224286,
-0.01874603,
-0.004428381,
-0.017928071,
0.007013,
0.0077370955,
-0.01647988,
-0.6251895,
-0.02121332,
0.019926038,
-0.008528237,
-0.005430717,
0.034515224,
-0.0037847403,
-0.020127175,
-0.031726114,
0.028239729,
0.005353614,
0.023868335,
0.021736277,
-0.019657854,
-0.0036472962,
-0.052134883,
-0.01466964,
-0.024351066,
0.022071507,
0.0031008723,
-0.011518484,
0.002197429,
-0.010599955,
0.027126767,
0.0020331666,
0.007938233,
0.045054838,
-0.0026164658,
0.012235874,
0.031189747,
-0.005212818,
0.010190975,
-0.013342132,
-0.02102559,
0.044759836,
0.02070377,
-0.015273053,
0.017740343,
-0.0012453774,
0.023050377,
-0.016453061,
0.0027002732,
0.02251401,
-0.009855745,
-0.011766553,
0.014026,
0.009272446,
0.010030065,
0.019268988,
-0.009238923,
0.013194631,
0.018692393,
-0.006329132,
0.009768586,
0.03312067,
-0.0072141374,
0.024096292,
-0.012604627,
-0.004005992,
-0.031726114,
0.013214745,
0.01158553,
-0.031913843,
0.004381449,
-0.00432446,
0.020100357,
-0.012879515,
-0.009299264,
0.01613124,
-0.013275086,
0.009064604,
0.0060441867,
-0.014790323,
0.018209662,
0.0043076985,
0.01778057,
0.00076348503,
-0.016037377,
-0.002334873,
0.020033311,
-0.0112972325,
-0.0102312025,
-0.017525796,
0.006590611,
0.007931529,
-0.0010911719,
-0.025316527,
0.02412311,
-0.006821919,
0.0073616384,
-0.003995935,
0.0030539401,
-0.005769299,
-0.018062163,
-0.02866882,
0.019121487,
0.0036875238,
0.010056883,
0.0023767767,
-0.037894335,
-0.0035333184,
-0.036177963,
0.00091852865,
0.015742375,
0.030117013,
0.020395359,
-0.017968299,
-0.0010660297,
0.025396982,
-0.037733424,
0.006966068,
0.01027143,
-0.0055379905,
0.0025594768,
0.010291544,
-0.02429743,
0.02153514,
0.0022275997,
-0.01778057,
-0.010190975,
0.021789914,
0.0018236481,
0.0017146986,
-0.010921775,
0.0039691166,
0.03177975,
0.0052765114,
-0.004334517,
0.010103815,
-0.008521533,
0.012041441,
0.0043076985,
0.02724745,
-0.048112128,
0.033683855,
-0.00067674444,
0.02640267,
0.016184878,
0.018142616,
-0.020596497,
-0.028910186,
-0.017646478,
0.012953266,
-0.020502632,
0.0032735155,
-0.016453061,
-0.020516042,
-0.0043646875,
0.03164566,
0.0024002427,
0.0055949795,
-0.024042655,
-0.004505484,
0.01823648,
0.019215351,
-0.0060508912,
-0.017539205,
-0.010720638,
0.0013794692,
-0.023492878,
-0.006885613,
0.023439242,
-0.015554646,
0.018504664,
-0.01794148,
-0.00485077,
-0.0067247027,
0.015447373,
-0.0042741755,
-0.021991052,
0.014817141,
-0.0054005464,
-0.022540828,
-0.0026935686,
0.0027606145,
-0.0056653777,
-0.0105195,
0.009031082,
-0.018169435,
-0.024981298,
-0.0123967845,
-0.017874435,
0.00032077267,
-0.011900645,
0.030304741,
0.027260859,
0.013985773,
0.0061648693,
0.023318559,
0.018370572,
-0.015997149,
0.023573333,
-0.02998292,
0.008715966,
0.00021643251,
-0.037089784,
0.019751718,
0.002336549,
0.0013761169,
0.035024773,
-0.012879515,
-0.017820798,
0.02102559,
-0.026174715,
-0.0077438,
-0.03014383,
-0.008219826,
-0.019255579,
0.004679803,
0.02511539,
0.0040596286,
0.0066006677,
0.00076390407,
-0.011102799,
0.01614465,
0.015903285,
0.0051893517,
0.0052463408,
-0.013322018,
0.0140528185,
-0.0052563976,
-0.003848434,
0.020261267,
-0.0016778234,
-0.0047434964,
0.013234858,
0.018558301,
0.0069928863,
0.0059402655,
0.0043177553,
-0.006047539,
-0.009326083,
-0.0014791999,
0.0035534322,
-0.000785694,
0.01744534,
0.01295997,
-0.010291544,
0.026644036,
-0.0026164658,
0.009909382,
-0.010076997,
0.011860417,
0.01068041,
0.007616413,
-0.019939447,
0.04290937,
0.002572886,
-0.017606251,
-0.003995935,
-0.025839485,
0.008508123,
-0.013985773,
-0.024552204,
0.0032165265,
0.0052563976,
-0.0023181115,
0.0052329316,
0.018021936,
0.005112249,
0.01516578,
-0.011598939,
0.0018102389,
-0.017820798,
-0.0059838453,
-0.007033114,
-0.0027287677,
-0.02476675,
-0.03542705,
-0.0144148655,
-0.035507504,
0.019148305,
0.021468094,
-0.026281988,
0.018035345,
0.0072074328,
0.02609426,
0.0054139555,
0.0114447335,
0.016439652,
0.0014305917,
-0.018370572,
0.026201533,
0.02708654,
-0.0027622906,
0.0035567842,
-0.034488406,
-0.025142208,
-0.0008799773,
-0.005635207,
0.007066637,
0.001150675,
-0.0049513387,
-0.0030271218,
-0.012483944,
-0.0042507094,
0.01940308,
-0.007629822,
0.008608692,
-0.005340205,
0.0038216156,
0.0091316495,
-0.009078013,
-0.0059536747,
0.04387483,
0.0013476224,
-0.011484961,
-0.014978051,
-0.0018471142,
-0.031538386,
-0.002026462,
-0.0014029352,
-0.0014272394,
0.0012244255,
0.014173501,
0.0041266745,
0.024029246,
0.004130027,
0.024176747,
0.013482928,
-0.028937005,
-0.024149928,
-0.010284839,
-0.0031830035,
0.01615806,
0.014522139,
-0.006446462,
0.012215761,
-0.039878894,
0.009265741,
-0.0336034,
-0.029205188,
0.025839485,
-0.015071915,
0.00039934207,
0.016453061,
-0.0036875238,
-0.00022020384,
-0.006081062,
0.018665574,
0.0106401825,
-0.027207222,
-0.0041601975,
0.0013937164,
0.014696458,
0.014039409,
0.013878499,
0.040844355,
0.013442701,
0.020676952,
0.01744534,
0.03014383,
-0.004974805,
-0.01483055,
-0.003018741,
0.016050786,
0.011330755,
0.010117224,
-0.0072275465,
-0.023734244,
0.028025182,
0.018464437,
-0.009124945,
0.023358786,
0.013107471,
0.018880121,
0.008903694,
-0.009922791,
0.007200728,
0.01059325,
-0.0007835988,
0.011632461,
0.0010031741,
-0.021722868,
0.009587562,
-0.029151551,
-0.016895564,
-0.025182435,
0.005092135,
-0.0010685439,
0.025826076,
-0.014388047,
0.010646887,
-0.019778537,
-0.0072074328,
-0.027810635,
0.016225105,
-0.0076231174,
-0.017485568,
-0.022286054,
0.008501419,
-0.013945545,
-0.013596906,
-0.012403489,
0.007837664,
-0.0211865,
-0.030572925,
0.024538795,
0.021950824,
0.023331968,
0.02708654,
-0.020502632,
-0.0003073635,
0.023117423,
-0.002696921,
-0.02510198,
0.009560743,
-0.035856143,
0.006684475,
0.009895973,
0.02593335,
-0.009842336,
-0.017512387,
-0.003690876,
-0.000098735545,
-0.014026,
0.024056064,
-0.0045121885,
-0.021763096,
0.012658264,
0.0059268563,
0.02577244,
0.009815518,
-0.015501009,
-0.01630556,
-0.028910186,
-0.034542043,
-0.0064833374,
0.0007848559,
-0.028293366,
0.0035802503,
-0.0103451805,
-0.02705972,
-0.015353508,
0.003268487,
-0.014119864,
0.002867888,
0.009889268,
-0.0038015018,
0.033817947,
0.021494912,
0.007401866,
0.005544695,
-0.030948382,
-0.012457126,
-0.018156026,
0.014548957,
0.0021471446,
-0.033496127,
0.0019946152,
-0.027448587,
-0.006456519,
-0.025048343,
0.013657248,
-0.008038802,
0.040173896,
0.008347213,
-0.0121017825,
-0.013851681,
-0.011619053,
-0.0049613956,
0.0005292435,
0.017740343,
-0.014951233,
-0.025705393,
0.008675738,
0.01354327,
-0.019268988,
0.03363022,
-0.03556114,
0.007468912,
0.025021525,
0.021119455,
0.011719621,
-0.007629822,
0.0038048541,
-0.00355008,
-0.010760865,
-0.014026,
-0.055084903,
0.013999182,
-0.015460782,
0.02998292,
0.01745875,
0.042131636,
0.01336895,
-0.009272446,
0.026804946,
0.004176959,
0.0076365266,
-0.011840303,
0.02169605,
-0.023774471,
0.013395769,
-0.0127119,
0.004840713,
0.02460584,
-0.035668414,
0.015621692,
0.048487585,
-0.024243793,
-0.025732212,
0.014964642,
-0.020355131,
-0.031860206,
0.019805355,
-0.019805355,
-0.004884293,
-0.04092481,
0.00030610638,
-0.014227137,
0.0112637095,
0.0022979977,
0.006865499,
0.008387441,
-0.025477437,
0.02901746,
-0.0013618696,
0.018531483,
-0.0101976795,
-0.0089171035,
-0.0060542435,
-0.010090406,
0.010720638,
-0.000079040816,
0.017498977,
0.008253349,
0.0065503833,
0.0007802465,
0.004864179,
-0.033335216,
-0.046663936,
-0.011960986,
-0.01761966,
-0.018129207,
-0.0019325977,
-0.01761966,
-0.026965857,
0.0018387334,
-0.005065317,
-0.018933758,
0.013945545,
-0.022205599,
-0.017069884,
0.04760258,
-0.002983542,
0.028105637,
-0.010016656,
0.029446553,
0.033388853,
-0.0056720823,
-0.0075560715,
-0.040334806,
-0.014253955,
-0.015045097,
0.045242567,
0.017083293,
-0.018705802,
0.0062587336,
0.009145059,
0.008011984,
0.0030355025,
-0.0019141601,
-0.0064196438,
-0.012188942,
-0.0062788473,
0.010760865,
-0.0152194165,
-0.029473372,
-0.03472977,
0.00055731897,
0.02347947,
-0.007643231,
-0.00227956,
-0.010921775,
0.024324248,
-0.0019862344,
-0.008635511,
0.009721654,
-0.013013607,
-0.010351885,
-0.012007918,
-0.02036854,
-0.015125552,
-0.02203128,
0.030733835,
0.013690771,
0.02052945,
0.009332787,
-0.015943512,
0.00087830116,
-0.008273463,
-0.0070062955,
0.044438016,
-0.01246383,
0.007844369,
-0.0009495374,
-0.0050384984,
0.008615397,
-0.025986986,
-0.017740343,
-0.01728443,
-0.025718803,
0.003516557,
0.01352986,
0.010700524,
-0.018035345,
0.019832173,
-0.015501009,
-0.027837453,
-0.033388853,
-0.01580942,
0.019255579,
-0.05116942,
0.018705802,
0.00092523324,
0.019429898,
0.015863057,
0.008870171,
-0.014924414,
-0.019510353,
0.028481092,
-0.022245826,
0.037357967,
0.011324051,
-0.00252763,
-0.023117423,
0.008850058,
-0.015916694,
-0.022084916,
0.004461904,
-0.019188533,
-0.015930103,
0.01597033,
-0.005598332,
0.019148305,
0.02478016,
-0.012182238,
0.007924824,
0.0067314073,
0.014723277,
-0.007931529,
0.0071068644,
0.002413652,
0.0018571711,
-0.011491666,
0.017713524,
0.0029550474,
-0.0040126964,
-0.006795101,
-0.0028326889,
0.026617218,
-0.016882155,
-0.0024471749,
-0.027542451,
0.0068487376,
-0.028722458,
0.0019677968,
-0.0083270995,
-0.00250584,
-0.012644854,
0.031538386,
-0.012048146,
-0.01906785,
-0.019496944,
0.013254972,
-0.0041836635,
0.01092848,
-0.010834616,
0.009600971,
0.015393736,
-0.03279885,
-0.014843959,
0.009976428,
-0.018839894,
0.029205188,
0.016841928,
-0.00521617,
-0.019255579,
0.019952856,
-0.058464013,
-0.023828108,
0.010620069,
0.018370572,
-0.022326281,
-0.014602594,
-0.020073539,
0.010807797,
-0.0046429276,
0.030519288,
0.013496337,
-0.02543721,
0.0005707281,
-0.0048340084,
0.0034461587,
-0.02086468,
-0.020314904,
-0.018223071,
0.010418931,
-0.012752128,
-0.00075594237,
0.028910186,
-0.03033156,
0.030304741,
-0.01420032,
0.008521533,
0.009225514,
0.018290117,
0.016868746,
-0.016560335,
0.0077840276,
0.02169605,
0.0046865074,
-0.005769299,
-0.0024991354,
-0.022768784,
0.013590202,
0.013918727,
-0.0067481687,
-0.026523354,
0.010338476,
-0.029768374,
0.023720834,
0.005021737,
0.011143027,
0.030197468,
0.0050250893,
-0.00749573,
-0.020690361,
-0.006309018,
-0.007287888,
0.0057994695,
0.014133274,
0.015930103,
-0.009124945,
0.012866106,
-0.0025091923,
-0.02478016,
-0.011974395,
0.003982526,
0.002574562,
-0.03912798,
0.0105262045,
-0.012416898,
-0.014616003,
-0.014964642,
-0.018021936,
-0.021012181,
-0.03472977,
0.0014155064,
0.003449511,
-0.007958347,
0.007462207,
-0.013489633,
-0.0011808457,
0.00961438,
0.0018253243,
0.012524172,
0.006912431,
0.025289709,
0.18257937,
-0.012222465,
-0.0003656096,
0.0015663595,
-0.0076097082,
-0.012363262,
0.016453061,
0.00009543563,
-0.011639166,
-0.004907759,
0.019470125,
0.024337657,
-0.004931225,
0.0024672886,
0.010908366,
-0.028078819,
-0.02219219,
0.0012445393,
0.003724399,
-0.006127994,
0.0034109596,
-0.014575776,
0.00082927383,
-0.0056150933,
0.06339859,
0.015045097,
-0.015460782,
0.028937005,
0.024579022,
0.0008208931,
-0.036177963,
0.030251104,
-0.007502435,
0.005122306,
0.005511172,
0.0010987145,
-0.018652165,
-0.0036137733,
0.018021936,
-0.009091422,
0.0069057266,
0.0019024271,
-0.028561547,
-0.002460584,
-0.004703269,
0.015045097,
-0.004471961,
-0.0020800987,
-0.016050786,
-0.008105848,
-0.03309385,
0.03427386,
0.0061883354,
0.017244203,
0.011257005,
0.0071068644,
0.018611938,
0.025410391,
0.007287888,
0.020650133,
-0.02428402,
0.0064196438,
-0.03845752,
0.009741767,
-0.021092637,
0.008333804,
-0.009661312,
-0.010539614,
0.022406736,
-0.027542451,
-0.006241972,
-0.0005451669,
-0.0040897992,
0.00448537,
-0.010304953,
-0.023278331,
0.026778128,
0.02036854,
0.038672067,
0.023385605,
0.010264725,
0.0024622602,
-0.049426228,
-0.02315765,
0.012624741,
-0.023264922,
0.016613971,
-0.0064364052,
-0.03961071,
-0.012376671,
0.02478016,
-0.0049915663,
-0.00248405,
-0.0022208951,
-0.005759242,
-0.022219008,
-0.010043474,
0.011069276,
-0.016506698,
-0.0066911797,
-0.03942298,
0.061038576,
0.020945136,
0.03647296,
0.015460782,
0.018947167,
-0.0021555254,
0.012323034,
-0.009869155,
-0.021950824,
0.015930103,
-0.011122913,
0.006717998,
-0.013670657,
-0.009600971,
0.0109687075,
0.0155144185,
-0.01214201,
0.040871173,
0.009768586,
-0.007763914,
-0.028025182,
-0.016399425,
0.02675131,
-0.016184878,
0.0007697706,
-0.020998772,
0.014441684,
-0.013060539,
-0.025169026,
0.008575169,
-0.0029215245,
0.0046663936,
0.00092523324,
0.0142673645,
-0.009084717,
0.0056385593,
-0.016265333,
-0.020636724,
0.0265904,
-0.01646647,
0.015071915,
0.006094471,
-0.0033506183,
0.0047233826,
-0.018437618,
0.027944727,
0.014213729,
-0.021052409,
-0.021159682,
-0.0103787035,
-0.0119207585,
-0.014026,
-0.009849041,
0.012175533,
-0.013630429,
-0.016225105,
-0.018558301,
0.010573137,
0.0023449298,
-0.013482928,
0.008058916,
-0.010472568,
-0.006298961,
0.0074420935,
-0.017096702,
-0.16820472,
0.0016191582,
0.014481911,
-0.008555056,
0.009493697,
0.031752933,
-0.0092054,
-0.0029516951,
-0.010854729,
0.0077438,
0.02267492,
0.021173092,
-0.042614367,
-0.037840698,
0.0018571711,
-0.010076997,
-0.007629822,
0.053448983,
0.018973986,
0.016908973,
0.025142208,
-0.016908973,
0.010660296,
-0.0036607054,
0.011183254,
0.0065068034,
0.022138553,
0.013000198,
-0.017043065,
-0.030197468,
-0.008052211,
-0.00656044,
0.020596497,
-0.0052195224,
0.022299463,
0.03180657,
-0.007549367,
-0.0030472355,
-0.0021186501,
0.03261112,
0.03574887,
0.0063727116,
-0.016734654,
0.028132455,
-0.003724399,
0.053690348,
-0.01971149,
-0.021588776,
0.008601988,
0.0018923702,
0.011357574,
-0.00013775835,
-0.005655321,
0.0077706184,
0.013161108,
-0.0030220933,
0.0025913236,
0.031592023,
-0.0061313463,
0.01516578,
0.0045289495,
-0.015728965,
0.02901746,
-0.00026357415,
0.007871187,
-0.02038195,
-0.011391097,
0.02885655,
-0.031216566,
0.009232218,
-0.009634494,
-0.0106737055,
0.02184355,
-0.010278135,
0.026697673,
0.0128392875,
0.0038082064,
0.00448537,
-0.000022078002,
0.020314904,
-0.005501115,
0.007924824,
-0.025544483,
-0.0063928254,
-0.02251401,
0.0065068034,
0.00848801,
0.03132384,
0.0048340084,
0.002494107,
0.014696458,
-0.0037545697,
-0.008193008,
-0.009031082,
0.025852894,
0.01295997,
-0.010653592,
-0.012611331,
-0.01532669,
0.010298248,
0.015728965,
-0.029848829,
-0.025464028,
-0.0048105423,
0.03210157,
-0.0071269777,
-0.023023559,
0.002242685,
0.06409587,
-0.009218809,
0.019604217,
0.013730998,
-0.009916087,
0.022259235,
-0.004233948,
0.023197878,
0.002572886,
-0.0012721957,
-0.018692393,
-0.013389064,
0.063344955,
0.01842421,
0.011391097,
0.033147488,
-0.010278135,
-0.0153669175,
-0.13859726,
-0.011357574,
0.014253955,
0.014535548,
-0.009674721,
0.010418931,
-0.010573137,
0.035319775,
-0.009399833,
0.023653788,
-0.002038195,
-0.017512387,
-0.0065202126,
-0.009124945,
0.0004303508,
0.0022728555,
0.018464437,
-0.0184108,
-0.008005279,
0.029446553,
0.0020432235,
0.003600364,
-0.0006050891,
0.0042507094,
0.007944938,
-0.004277528,
-0.0349175,
0.007415275,
0.0077370955,
0.006127994,
-0.00023214638,
-0.0035065,
0.02998292,
-0.009828927,
-0.026349034,
-0.015407145,
-0.0016292151,
-0.018558301,
0.035963416,
-0.010439045,
-0.002346606,
-0.0025661814,
0.005226227,
-0.006265438,
0.015460782,
-0.025370164,
-0.013590202,
0.01205485,
-0.0026281988,
-0.023090605,
-0.027461996,
-0.04728076,
-0.01924217,
0.0028863256,
0.007777323,
-0.011545302,
0.024364475,
0.0225006,
-0.010056883,
-0.018451028,
0.016171468,
0.006181631,
-0.021924006,
-0.016493289,
0.014924414,
-0.01696261,
-0.0067314073,
-0.041166175,
0.032825667,
-0.025893122,
-0.00749573,
-0.00066333526,
-0.013643838,
0.0071269777,
-0.01779398,
-0.0025427153,
-0.03475659,
-0.031243384,
0.010700524,
-0.02380129,
-0.0064263484,
-0.016332379,
0.01433441,
-0.009466879,
0.035614777,
-0.002093508,
0.013469519,
0.00038551385,
0.0022644748,
0.0076231174,
-0.015728965,
0.036285233,
0.010392113,
-0.022245826,
-0.020422177,
0.0015923398,
0.01874603,
0.0037411605,
0.02283583,
0.021146273,
-0.01361702,
-0.0254238,
-0.04969441,
0.0060408344,
-0.0013140994,
0.0024756694,
0.009078013,
-0.021508321,
0.0014431628,
-0.013811453,
-0.0035936595,
-0.0005372052,
0.0050988398,
0.019108078,
-0.017820798,
-0.0022393328,
-0.022205599,
-0.020328313,
0.036741145,
-0.007448798,
0.013549974,
0.003600364,
0.015608283,
-0.0042406525,
0.0077035725,
-0.004233948,
-0.013690771,
-0.010512795,
-0.02821291,
0.018209662,
-0.015501009,
-0.019791946,
-0.0058866288,
-0.047709852,
-0.014924414,
0.0070532276,
-0.009037786,
-0.027837453,
0.013670657,
0.04191709,
0.03357658,
0.023600152,
0.00013692028,
-0.040683445,
0.00085315894,
-0.010418931,
-0.0019661207,
0.020006493,
-0.053368527,
0.008306986,
-0.007562776,
-0.006332484,
0.04044208,
0.0033640275,
0.008675738,
-0.026349034,
0.0027522338,
-0.0011297233,
-0.016251924,
-0.020636724,
-0.0083270995,
-0.010479272,
0.0017247555,
0.014280774,
-0.012135305,
-0.02004672,
-0.0018202958,
-0.008213121,
-0.02329174,
0.009084717,
0.008521533,
-0.029097915,
-0.02933928,
0.0051759426,
0.013094062,
-0.00032642967,
0.016989429,
-0.009319378,
-0.024431521,
-0.011397801,
-0.02460584,
0.019027622,
-0.009218809,
0.0049345773,
0.0073080016,
0.0106401825,
0.042963006,
0.008072325,
-0.015541237,
0.02558471,
0.009044491,
0.017847616,
-0.006681123,
0.0018588472,
0.026992675,
0.019215351,
0.023667198,
0.01614465,
-0.0015252939,
0.021494912,
-0.010204384,
0.04253391,
0.022299463,
-0.0019778537,
0.008038802,
-0.019644445,
-0.017552614,
0.03810888,
-0.028615184,
-0.038537975,
-0.00873608,
-0.007167205,
-0.0027069778,
0.002313083,
-0.005182647,
-0.0020633372,
-0.0223531,
0.031404294,
-0.013730998,
0.0054608877,
-0.021253547,
0.035534322,
0.017700115,
-0.0051994086,
-0.010700524,
-0.005145772,
0.0046663936,
0.0080320975,
0.027220631,
-0.010894957,
0.029795192,
-0.0076834587,
0.01794148,
0.0068789083,
-0.0309752,
-0.014817141,
-0.017324658,
-0.013891908,
0.0013719265,
0.022433555,
-0.012557695,
0.094776064,
0.004086447,
-0.029232007,
-0.0035936595,
-0.006681123,
0.00872267,
0.014253955,
0.007462207,
-0.028802913,
-0.018129207,
0.038591612,
-0.0119542815,
0.02284924,
-0.048165765,
-0.023251515,
0.020770816,
-0.0012537581,
0.011914054,
0.009875859,
-0.007898006,
0.0020080244,
-0.00815278,
0.011578825,
0.023667198,
-0.04454529,
-0.011035753,
0.02478016,
0.002197429,
-0.01615806,
-0.0267379,
0.009594266,
0.006490042,
-0.039717983,
-0.00052295794,
0.006979477,
-0.012095078,
-0.023761062,
-0.014870778,
0.010412226,
0.0211865,
0.008568465,
0.0045959954,
0.0012437012,
-0.011143027,
0.005601684,
-0.008695852,
-0.0074756164,
0.008085734,
-0.015876466
] |
Our understanding of the origins and the biological functions of different peripheral B cell subsets continues to evolve. Some understanding has been obtained regarding the synergy between BCR-derived signals and other receptors and signaling pathways that drive the development of follicular, marginal zone, and B-1 B cells, but this remains a complex and poorly understood issue. More recent information regarding the origins of B-1 and B-2 B cells, the ability of follicular B cells to mature both in the bone marrow and the spleen, the existence of a definable precursor for MZ B cells, and the ability of follicular B cells to occupy two distinct nich | [
-0.03462951,
-0.0023187008,
0.003932731,
-0.0049930923,
-0.02987802,
0.01646915,
-0.0035669738,
-0.0027666697,
-0.05014568,
-0.016509417,
0.008529866,
-0.00908018,
-0.017019466,
0.009167424,
-0.0102948975,
0.0031894718,
0.02343532,
0.000671534,
0.0038857532,
0.00372133,
-0.013502825,
0.009529826,
-0.004677668,
-0.010375431,
-0.0040166206,
-0.00063881715,
-0.0027113028,
-0.040159494,
-0.025556043,
0.004808536,
0.012637087,
0.030737046,
-0.00919427,
0.0033169836,
-0.011435792,
-0.027784143,
-0.0032733611,
-0.010744544,
-0.010073429,
0.01124788,
0.015422212,
0.006778257,
-0.02091193,
-0.0076775504,
-0.001335518,
0.0062715653,
0.007643995,
-0.010764677,
-0.019341521,
0.0346832,
0.02144882,
-0.0026894915,
-0.01663022,
0.007664128,
-0.018750941,
-0.018965697,
-0.0036105963,
0.037126057,
-0.008254709,
-0.02021397,
-0.01212704,
-0.0040468206,
-0.0019344877,
-0.0071272366,
-0.0032146387,
0.025354708,
0.0006807618,
0.012006239,
-0.016227549,
-0.026790893,
0.018589873,
0.008536577,
0.0069863023,
0.004499823,
0.030012242,
-0.0006102948,
-0.030334378,
-0.014724253,
0.003400873,
-0.0037079079,
0.0151135,
-0.015368523,
-0.012731043,
0.0500383,
0.0021005885,
0.006550078,
0.009771428,
0.04171648,
0.0052112043,
0.00791244,
0.017918758,
0.011268013,
0.03191821,
0.017891914,
-0.0012717621,
-0.011945839,
0.0196905,
0.021072997,
-0.004852158,
-0.014965855,
-0.02056295,
0.0050132256,
-0.012113618,
-0.025207063,
-0.04389089,
-0.002129111,
0.001327129,
-0.02038846,
0.010362009,
0.010140541,
-0.01008014,
0.03140816,
0.00021664417,
-0.033072524,
0.032777235,
0.011321702,
-0.007623861,
-0.01189215,
-0.009160713,
0.005764874,
0.015100078,
0.025032572,
0.009160713,
-0.03978367,
0.021623312,
0.010247919,
-0.018442228,
-0.015475902,
-0.0017163755,
0.008274842,
0.008617111,
0.0147108305,
-0.027837832,
0.009751295,
-0.012610243,
0.005016581,
-0.023408476,
-0.003949509,
0.0022281003,
-0.00504007,
0.010878767,
0.03240141,
-0.0022834672,
-0.01247602,
0.0135296695,
0.02160989,
0.025743954,
0.006761479,
0.0057212515,
0.00034457538,
-0.022817895,
-0.025381552,
0.03127394,
-0.01652284,
0.013294779,
-0.0063420325,
-0.01991868,
0.0373945,
-0.011576726,
0.0073621264,
0.017355023,
-0.002404268,
0.021287754,
0.010939167,
0.025180219,
0.021354865,
0.0004974637,
0.0007893985,
0.011106946,
0.007744662,
-0.0027784142,
-0.0052279825,
-0.0077782176,
0.009167424,
-0.014536341,
0.020952197,
0.015569857,
-0.0051642265,
-0.027649919,
-0.01528799,
-0.0136504695,
-0.0045300233,
0.0023354786,
0.0014336684,
-0.014348429,
0.006741346,
0.02554262,
-0.036401253,
-0.02126091,
-0.009811695,
-0.003644152,
-0.0016199028,
0.029555885,
-0.01412025,
-0.6322436,
-0.0010217719,
0.020026058,
-0.013543092,
-0.0044629117,
0.014026294,
-0.017140266,
-0.017999291,
-0.022281002,
0.016563106,
-0.022401804,
0.017408712,
-0.017408712,
-0.026374802,
-0.010865345,
-0.032723546,
-0.0014596741,
-0.016643642,
0.020791128,
-0.013462557,
-0.011321702,
-0.01107339,
-0.02338163,
0.026186889,
-0.0056843404,
-0.011502903,
0.028911615,
-0.0051709376,
0.0027515697,
0.03181083,
-0.014751098,
0.010992857,
0.014200784,
-0.02050926,
0.043515068,
0.011496192,
-0.009523115,
0.019019386,
0.015972527,
0.037985083,
0.01863014,
0.0022364892,
0.01904623,
-0.020885084,
-0.012288108,
0.018549606,
0.005748096,
0.040052116,
-0.00078394567,
-0.014576608,
0.0112277465,
0.0018556317,
-0.018308004,
-0.0087379115,
0.004241444,
0.0023774232,
0.012214284,
-0.012838421,
-0.015838303,
-0.013227668,
0.002583791,
0.03170345,
-0.040454786,
-0.024441991,
-0.008724489,
0.018106671,
-0.033072524,
-0.010939167,
0.009509693,
0.006808457,
-0.003942798,
0.01850934,
-0.008939246,
-0.00035275458,
-0.002301923,
0.013502825,
0.013073311,
0.0006337838,
-0.009543248,
0.012663932,
-0.0021022663,
0.0009236214,
-0.008221153,
0.008811734,
0.013737715,
-0.018818052,
-0.01528799,
0.021636734,
0.00039784508,
0.016106749,
-0.01130828,
-0.0017465756,
-0.0024395015,
-0.038334064,
-0.0089258235,
0.027998898,
0.0032230276,
0.0107915215,
0.016912086,
-0.03151554,
-0.013140423,
-0.01201295,
0.01394576,
0.009013068,
0.014039717,
0.0016089971,
-0.023180297,
-0.018146938,
0.043300312,
-0.05771585,
0.006402433,
0.010999568,
-0.014321584,
0.014683986,
0.011221035,
-0.013153845,
0.007630572,
0.0063487436,
0.008952668,
-0.016965777,
0.030173311,
0.0047313576,
0.0077245287,
-0.022455493,
0.010751255,
0.0055568283,
0.0014445741,
-0.007717817,
0.0032683278,
-0.026978806,
-0.01558328,
-0.012925666,
0.018254315,
-0.019703923,
0.027072761,
-0.002056966,
0.032589324,
0.0059494306,
-0.0043152664,
-0.048910826,
-0.0540113,
-0.015046388,
0.00042112436,
-0.026468758,
-0.010301609,
-0.013502825,
-0.0010553276,
0.008556711,
-0.0019814656,
0.0064762556,
0.013603492,
0.00018550025,
-0.024884928,
-0.0014865188,
0.006439344,
0.0049494696,
-0.027569385,
-0.019824725,
0.0050870483,
-0.004311911,
-0.012932377,
-0.00196301,
-0.0152074555,
0.024938617,
-0.0042615775,
-0.0129055325,
0.004295133,
0.008019819,
0.0098586725,
-0.036240187,
0.0038991754,
-0.011066679,
-0.019287832,
0.01587857,
0.002355612,
0.0010939167,
-0.025797643,
0.011905572,
-0.018992541,
-0.017905336,
-0.0005536695,
-0.015489324,
-0.007650706,
-0.007758084,
0.01704631,
-0.002865659,
0.029716952,
-0.011019701,
-0.015516168,
0.02144882,
0.013878649,
0.02987802,
-0.020428726,
0.017596623,
-0.014079983,
-0.033958398,
-0.0064863223,
0.008415776,
-0.013509536,
0.018214049,
0.018965697,
0.008402354,
0.014267895,
-0.001956299,
0.015529591,
-0.028482102,
0.0025284241,
-0.012630376,
0.010375431,
0.014039717,
0.015220878,
0.001178645,
0.005348783,
-0.022294424,
-0.00044041892,
0.007529905,
0.007066836,
0.0077647953,
-0.0019579767,
-0.0031156493,
0.0012231063,
0.01751609,
0.019784456,
0.014563186,
-0.013959182,
0.009529826,
0.02413328,
-0.01118748,
0.0137175815,
0.012026372,
-0.0080533745,
0.0121605955,
0.011469347,
0.016536262,
0.0013682347,
0.009758006,
0.012388774,
-0.010865345,
0.040293716,
-0.013784693,
0.0020619994,
0.024361458,
0.003855553,
0.025287597,
0.009919073,
-0.03854882,
0.02202598,
0.004077021,
0.002340512,
0.004499823,
-0.009328492,
-0.023233986,
-0.011959261,
-0.006301766,
0.009355336,
0.0011023056,
-0.0017448978,
-0.010952589,
0.009402315,
0.029180061,
0.016214127,
0.0018120093,
0.012308241,
-0.032079276,
-0.013462557,
0.024173547,
0.0034595956,
-0.021421976,
-0.019677078,
0.013207534,
-0.025569465,
0.004217955,
0.014845054,
-0.03275039,
0.016898664,
0.007798351,
0.027300939,
0.00779164,
0.004345467,
0.023623232,
-0.024858084,
-0.018066404,
0.014898743,
0.040105805,
-0.004697802,
-0.009013068,
-0.012737754,
-0.013442424,
-0.006345388,
-0.009180847,
0.021542776,
-0.005875608,
-0.018737517,
-0.011294858,
-0.007845329,
-0.01195255,
0.010919034,
-0.010757966,
0.02495204,
0.0012642121,
-0.012878688,
-0.012167307,
-0.01950259,
0.009764717,
0.02977064,
0.010113697,
-0.014737676,
-0.011704238,
-0.0071071032,
0.008717778,
-0.008268131,
-0.007550039,
0.018052982,
-0.008610399,
0.023086341,
0.0038186419,
0.008610399,
0.02338163,
0.020240815,
0.004177688,
-0.030200155,
-0.01828116,
0.0110398345,
-0.0077647953,
0.019516012,
0.019448899,
0.0016853365,
0.024522526,
0.009912362,
-0.009395604,
-0.0077715064,
-0.0061843204,
0.031059181,
-0.0022432003,
-0.0063487436,
0.004845447,
0.005946075,
0.0033572505,
-0.00021045732,
0.012335085,
-0.019542856,
-0.015153767,
0.020307926,
-0.0026844582,
0.008489599,
0.01247602,
0.020871662,
0.042978175,
-0.0010964334,
0.006778257,
-0.009402315,
0.031435005,
-0.0020938774,
-0.023233986,
-0.0015485968,
0.016267817,
-0.024495682,
0.011959261,
0.0063286102,
-0.00978485,
-0.001366557,
0.011751216,
0.00808693,
-0.0032867836,
0.0129458,
0.002739825,
0.007972841,
-0.0217978,
-0.01880463,
-0.0019126765,
0.0064930334,
0.0038521974,
0.01394576,
0.0038924643,
0.025972134,
-0.016147016,
0.007341993,
-0.0066574565,
-0.02115353,
0.013321624,
0.002364001,
-0.013113578,
-0.0002927737,
-0.014992699,
-0.0015477579,
-0.008415776,
0.033985242,
-0.0022834672,
0.016791286,
-0.03057598,
-0.0061843204,
-0.0150195435,
-0.013851805,
-0.012885399,
0.005372272,
-0.01863014,
-0.009966051,
-0.008147331,
0.02987802,
0.034710046,
0.017623467,
0.008335243,
0.0013481013,
0.019636812,
0.0012373674,
-0.039219934,
-0.011999528,
-0.027730454,
0.0017088255,
0.016831553,
0.024629904,
-0.029609574,
-0.0044931117,
0.014187361,
-0.0125968205,
-0.012388774,
0.0004087507,
-0.011033123,
0.0036340852,
0.010502943,
0.023153452,
0.0063185436,
0.012254552,
-0.010489521,
-0.013153845,
0.0025066128,
-0.031622916,
-0.013986027,
-0.00035275458,
-0.014858476,
-0.0052883825,
0.007375549,
-0.025126528,
-0.0061306315,
0.00044713006,
-0.011845171,
0.030495444,
0.007060125,
-0.00030913213,
0.024294347,
-0.002120722,
0.025905022,
0.024522526,
-0.014079983,
0.014053139,
-0.01582488,
0.039407846,
-0.023314519,
-0.04147488,
0.0011425725,
-0.0051575154,
0.004664246,
-0.033233594,
-0.0015930581,
-0.009154002,
0.034548976,
-0.010999568,
-0.009214403,
-0.033824172,
0.014039717,
-0.0010939167,
-0.005097115,
-0.0072950153,
-0.0077715064,
0.0042984886,
0.008516444,
0.009711027,
-0.014952432,
0.030951804,
-0.03374364,
0.0018002648,
0.028670013,
0.0016811419,
0.01716711,
-0.021193797,
0.00914058,
-0.0021744112,
-0.0044192895,
-0.011596859,
-0.030495444,
-0.00006742604,
-0.03766295,
0.026911693,
0.053044893,
0.006865502,
-0.00037771167,
0.018603295,
0.009261381,
-0.00796613,
0.004375667,
-0.02080455,
0.02513995,
-0.020710595,
0.018871741,
-0.021838067,
0.008321821,
0.0050199367,
-0.018120093,
0.035193246,
0.04493783,
-0.014361851,
-0.0104828095,
-0.011623704,
-0.020549528,
-0.030978648,
0.00670779,
-0.011992817,
0.009590227,
-0.031569228,
-0.016133593,
0.011576726,
-0.003038471,
0.0046743127,
-0.0055098506,
0.007919151,
-0.0033958396,
0.010328453,
-0.012288108,
-0.02026766,
-0.0027935144,
-0.009120447,
-0.015032966,
-0.003620663,
-0.001860665,
-0.0011249557,
-0.0069259023,
0.021744112,
-0.01909992,
0.033770483,
0.008469465,
-0.017623467,
-0.012113618,
-0.006315188,
-0.015556435,
-0.006301766,
0.008885557,
-0.021690423,
-0.009200981,
0.022415226,
-0.01505981,
-0.019609967,
0.0031760496,
-0.013798115,
-0.019032808,
0.036025427,
-0.033421505,
0.025905022,
-0.0239051,
0.020495838,
0.011053257,
0.0073017264,
-0.020965619,
-0.018912008,
-0.020764284,
0.012113618,
0.039032023,
0.035783827,
-0.008637244,
-0.014777943,
0.0032012165,
0.02038846,
-0.010536498,
-0.02536813,
0.006509811,
0.013596781,
0.0039729984,
-0.0091741355,
-0.015663814,
-0.016536262,
0.0018271094,
-0.010556632,
0.009516404,
-0.011710949,
-0.0037917972,
-0.0059427195,
0.05103155,
-0.018885164,
0.014670564,
-0.014227629,
-0.0015729247,
-0.011590148,
-0.016187282,
-0.0108989,
-0.008570133,
-0.00009946127,
0.032132965,
-0.015838303,
-0.0022415225,
0.02395879,
0.01142237,
-0.015529591,
0.0012541453,
-0.009435871,
0.04429356,
0.009348625,
0.007643995,
-0.0061373427,
0.005268249,
0.0036508632,
-0.0063185436,
-0.0032767167,
-0.0087916,
-0.013999449,
0.007341993,
0.043783512,
0.020750862,
-0.025354708,
0.0054024723,
-0.018428806,
-0.0021492443,
-0.038226686,
-0.029663263,
-0.0087312,
-0.040293716,
0.00011608184,
0.003228061,
0.0029025704,
0.027837832,
-0.006590345,
0.014630297,
0.0052883825,
0.028401569,
-0.015489324,
0.008603688,
0.02202598,
0.002520035,
-0.033582572,
-0.007845329,
-0.010570054,
-0.02202598,
0.0009705994,
-0.015073232,
-0.038280375,
-0.0074091046,
-0.004093799,
0.025113106,
0.020294504,
-0.016026216,
0.013100156,
0.00035757822,
0.024737282,
-0.002436146,
-0.018522762,
0.012355219,
0.006872213,
-0.016992621,
-0.001593897,
-0.029367972,
0.016160438,
0.016670486,
0.0073218597,
0.0150195435,
-0.00020552884,
-0.014066561,
-0.005425961,
-0.0005247277,
-0.024455413,
0.007060125,
-0.019408632,
-0.016563106,
-0.012670643,
0.006120565,
0.010516365,
-0.024388302,
-0.027368052,
0.012214284,
0.015140344,
0.020965619,
-0.001939521,
-0.016375195,
-0.003212961,
-0.041797016,
-0.02407959,
0.0037045523,
-0.026965383,
0.045555256,
-0.0027666697,
0.007140659,
-0.007288304,
0.0063353213,
-0.04488414,
-0.0071272366,
0.03626703,
0.014509496,
0.01575777,
0.02770361,
-0.01008014,
0.011811616,
-0.00024285958,
0.02150251,
-0.014603453,
-0.027381474,
0.004751491,
0.016254395,
0.022455493,
-0.0016828197,
-0.027623074,
-0.029636418,
0.02958273,
-0.031971898,
0.004640757,
0.03895149,
-0.02987802,
0.022656826,
0.009033202,
0.0103552975,
0.019381788,
0.02460306,
0.014670564,
-0.022468915,
-0.0042984886,
0.00076632894,
-0.0066306116,
-0.015032966,
-0.018992541,
-0.010925745,
0.0031273938,
0.018254315,
-0.010006318,
-0.017207377,
0.028052589,
-0.00386562,
0.025824487,
0.017972447,
0.0136504695,
0.024227235,
0.01236193,
0.0036005296,
-0.003070349,
-0.0048420914,
-0.008093641,
0.0015729247,
-0.005342072,
0.011388814,
0.012267974,
-0.013824959,
0.011791483,
-0.013100156,
-0.0049427585,
-0.011241169,
-0.017113421,
-0.044615693,
0.020979041,
0.0042280215,
-0.018589873,
0.002850559,
0.021301176,
-0.016992621,
-0.022307847,
-0.0013145456,
0.002191189,
0.008858712,
0.003110616,
-0.01816036,
-0.0048957807,
-0.012375352,
0.0031240382,
0.0068621463,
-0.008623822,
-0.0068319463,
0.1758857,
-0.030495444,
-0.012751176,
-0.0056340066,
-0.009556672,
-0.011241169,
0.002560302,
0.009590227,
0.012522997,
-0.0040669544,
0.01798587,
0.010402275,
-0.006170898,
0.00093368813,
0.034173153,
-0.008288264,
0.0034663067,
-0.007838618,
-0.0059225857,
0.0047078687,
0.0032096053,
-0.023220563,
0.0196905,
-0.0048991363,
0.041984927,
0.004187755,
-0.016187282,
-0.0012826676,
0.02173069,
0.004429356,
-0.021958867,
0.010200941,
-0.010610321,
-0.008281553,
-0.019677078,
-0.018294582,
0.0013254512,
-0.016254395,
0.007737951,
0.018563028,
0.01008014,
0.011905572,
-0.007878885,
0.01716711,
0.022012558,
0.024294347,
0.019328099,
-0.018026136,
-0.01171766,
0.004489756,
-0.02683116,
0.013375313,
-0.0033236947,
0.013328335,
0.015610124,
0.005513206,
0.022401804,
0.018214049,
-0.016657064,
0.02144882,
-0.019636812,
-0.00078646233,
-0.026992228,
0.02630769,
-0.009133869,
0.016428884,
0.009442582,
0.0006081976,
0.015663814,
-0.0001593897,
0.0098586725,
-0.00034415594,
-0.010221074,
-0.007932574,
0.007758084,
-0.015194033,
0.026911693,
0.015999371,
0.013824959,
0.007939285,
0.0010955945,
0.02536813,
-0.025274174,
-0.016710753,
0.0045300233,
-0.027274095,
0.029367972,
0.011999528,
0.000934527,
-0.012368641,
0.00843591,
-0.007570172,
-0.004838736,
-0.014657142,
0.0071809255,
-0.008247998,
0.004506534,
0.014348429,
0.00023027619,
-0.020885084,
0.0015016188,
0.07350046,
0.034253687,
0.02202598,
-0.021663578,
-0.0069997245,
-0.0071675032,
0.01558328,
0.015690658,
0.012321663,
0.007865462,
-0.033609416,
0.011677393,
-0.015341679,
-0.0027297584,
0.009952629,
0.010590187,
-0.013509536,
0.022012558,
-0.012590109,
-0.0074493713,
-0.025945289,
0.018710673,
0.034817424,
-0.009328492,
-0.007986263,
-0.017610045,
0.011784771,
-0.007281593,
-0.013932338,
0.0063185436,
-0.010751255,
-0.0047078687,
0.015341679,
0.011798194,
0.0011400558,
-0.00035506155,
-0.007825196,
-0.023327941,
-0.003989776,
-0.010496232,
-0.012569975,
0.029153217,
0.0051004705,
0.0033203391,
-0.01997237,
0.02724725,
0.011194191,
-0.0195697,
-0.0012130395,
-0.0068923463,
-0.022455493,
-0.024643326,
-0.013724293,
0.020495838,
-0.013798115,
-0.02654929,
-0.017274488,
0.016777864,
0.0005058526,
-0.01904623,
0.029260594,
0.00038756864,
-0.024455413,
0.010858634,
-0.0015267855,
-0.16826184,
0.003674352,
0.034065776,
-0.0069057685,
0.03637441,
0.0029965264,
-0.019247565,
-0.0063890107,
-0.018146938,
0.009677472,
0.052105334,
-0.00029738763,
-0.0175832,
-0.027649919,
-0.01634835,
0.003392484,
-0.030951804,
0.035998583,
0.012402196,
0.013408869,
0.03809246,
-0.028052589,
0.036884457,
-0.01446923,
0.011811616,
0.010469387,
0.0047078687,
0.018361693,
0.0018673763,
-0.020321349,
-0.012704198,
-0.00978485,
0.013824959,
-0.021556199,
0.008643955,
0.014845054,
-0.010013029,
-0.019341521,
0.0055970955,
0.009382182,
0.023327941,
0.018375115,
0.002905926,
0.0073084375,
-0.012194151,
0.044427782,
0.017086577,
-0.0035233514,
0.018012714,
-0.013757848,
0.015730925,
0.007053414,
0.00831511,
0.016039638,
0.008690934,
0.012314952,
-0.00990565,
0.008288264,
0.005120604,
0.0026106355,
0.012227707,
-0.01605306,
0.014428963,
-0.012912244,
-0.009630494,
-0.0056138732,
-0.009711027,
0.023462165,
-0.033018835,
-0.016428884,
-0.013811537,
-0.0052112043,
0.03637441,
-0.024441991,
0.024965461,
0.018173782,
0.0055266283,
-0.01493901,
0.014670564,
0.00037687278,
0.001484841,
0.008630533,
-0.032079276,
-0.006234654,
-0.018321427,
0.004657535,
-0.003550196,
0.022213891,
0.00667759,
-0.0014798075,
0.009073469,
-0.021489087,
-0.012563264,
-0.01124788,
0.0033840952,
0.021972291,
-0.006227943,
-0.019878414,
-0.014509496,
0.0041978215,
0.026441913,
-0.012670643,
-0.028482102,
-0.0045300233,
0.025341285,
-0.013308202,
0.002323734,
-0.0022717228,
0.05054835,
-0.013824959,
0.016536262,
-0.005456161,
0.0064829667,
0.011281435,
-0.032132965,
0.011563304,
0.010872056,
0.0030300822,
0.026764048,
-0.039273623,
0.06678932,
0.016536262,
-0.0011660615,
0.021462243,
-0.018052982,
-0.01072441,
-0.14850423,
-0.02683116,
-0.008724489,
0.0041541993,
0.0051508043,
0.0041038655,
-0.010744544,
0.025529196,
-0.019368365,
0.037636105,
-0.0145229185,
-0.018603295,
-0.009060047,
-0.015529591,
0.0063588102,
-0.012382063,
0.002545202,
-0.021435399,
-0.016012793,
0.008999646,
0.0111673465,
-0.007375549,
-0.03830722,
0.0055635395,
0.0130330445,
0.008697645,
-0.02554262,
0.007523194,
0.0037414636,
0.015073232,
0.007905729,
-0.013012911,
0.02425408,
-0.01019423,
-0.013757848,
0.013569936,
-0.021784378,
-0.03210612,
0.020401882,
-0.0014202462,
-0.011670682,
0.02501915,
0.006835302,
-0.0152074555,
-0.020200549,
-0.0043924446,
-0.012737754,
-0.0031156493,
0.019073075,
-0.016334929,
-0.030656513,
-0.026173467,
-0.05905808,
-0.019301254,
0.025287597,
-0.0017146977,
-0.0021962223,
0.02554262,
-0.023247408,
-0.0030770602,
0.0053454274,
0.0024009123,
-0.009207692,
-0.011616993,
0.0195697,
0.015650392,
-0.012663932,
-0.028965304,
0.015032966,
-0.020885084,
-0.0031643051,
0.01897912,
-0.015449057,
0.01476452,
-0.028079433,
0.008590266,
-0.017032888,
0.0015309801,
-0.0065064556,
-0.030227,
-0.008301687,
-0.011831749,
0.020079747,
-0.0050467816,
0.030844424,
0.00413071,
0.02437488,
-0.006979591,
0.00281197,
-0.016912086,
-0.0036340852,
0.03760926,
0.0066104783,
-0.012918955,
-0.024978884,
-0.015744347,
0.003119005,
-0.016979199,
0.03057598,
0.04523312,
-0.007952708,
-0.004657535,
-0.049071897,
0.021744112,
-0.007630572,
-0.0064359885,
0.018670406,
-0.009543248,
0.021717267,
-0.024267502,
0.00014869381,
0.046548504,
-0.014898743,
0.023287674,
-0.008952668,
-0.011207613,
-0.033931553,
-0.044400938,
0.018818052,
-0.021958867,
0.0069393246,
0.009261381,
-0.005405828,
0.0017096644,
0.05444081,
0.00389582,
-0.023999056,
0.005731318,
-0.030200155,
0.023395054,
0.006519878,
-0.004288422,
0.016442306,
-0.04488414,
-0.034199998,
0.0013925626,
-0.018482495,
-0.019314677,
0.01540879,
0.03320675,
0.018469073,
0.04469623,
-0.0077715064,
-0.026213733,
-0.015677236,
0.0056105177,
-0.02038846,
-0.011382103,
-0.029421661,
0.015475902,
0.007704395,
-0.008160753,
0.03363626,
0.014455807,
0.0031223604,
-0.06813155,
-0.007154081,
0.023797723,
-0.0046541793,
0.0055970955,
-0.019073075,
-0.008872135,
-0.0066876565,
0.044910986,
-0.010825078,
0.0026827804,
0.009717738,
-0.021005886,
-0.034710046,
0.012744465,
-0.0012189118,
-0.0065869894,
-0.020979041,
0.0152074555,
-0.01036872,
0.008335243,
0.010422409,
-0.03205243,
-0.00931507,
0.004476334,
-0.032723546,
0.031488694,
0.0031794051,
-0.01774427,
0.0088654235,
0.023878256,
0.034871113,
-0.0008841934,
-0.0005427639,
0.02185149,
-0.009878806,
-0.0019512655,
0.022240736,
0.018375115,
0.021166952,
0.02144882,
-0.002702914,
0.014200784,
0.0028052588,
0.019609967,
-0.013690737,
0.025851332,
0.0015762803,
0.0066071227,
0.033475194,
-0.011100234,
-0.012422331,
0.027998898,
-0.032830924,
-0.036857612,
-0.032965146,
0.021247488,
0.0058621857,
0.011650548,
0.03140816,
-0.0011232779,
-0.024052745,
0.013684026,
-0.020536106,
0.002733114,
-0.020536106,
-0.014952432,
0.023891678,
0.01171766,
0.0021693779,
0.0027045917,
-0.009482848,
-0.002803581,
0.014818209,
-0.010563343,
0.0068118125,
-0.0013606847,
0.024656748,
-0.02770361,
-0.032911457,
-0.0040971544,
-0.006432633,
-0.033233594,
0.01563697,
0.03111287,
-0.021677,
0.09170109,
0.013657181,
-0.009328492,
-0.007422527,
-0.028455257,
0.022227313,
0.016791286,
-0.0041273544,
-0.024535948,
-0.024911772,
0.023972211,
0.0056574955,
0.0097982725,
-0.008831867,
-0.037099212,
0.021663578,
-0.0014932299,
-0.020428726,
0.014160517,
-0.02126091,
0.020549528,
-0.027327785,
0.025166795,
0.014657142,
-0.025394974,
-0.000918588,
0.0033790618,
-0.02144882,
-0.008489599,
-0.036105964,
0.04609215,
-0.007892307,
-0.040803764,
0.008610399,
0.0061675427,
-0.0013371957,
-0.03409262,
-0.034951646,
-0.014415541,
0.033582572,
-0.012059929,
0.026858004,
-0.038011927,
-0.018240893,
-0.0075835944,
-0.013261223,
-0.012375352,
-0.023529276,
-0.010241208
] |
IL-10 gene transcription and IL-10 protein production was assessed in both type 1 (Th1) and type 2 (Th2) CD4+ human T cell clones by polymerase chain reaction and ELISA, respectively. Although Th2 clones apparently showed higher IL-10 mRNA levels, IL-10 mRNA expression was consistently found in Th1 clones, as well. Likewise, measurable IL-10 levels were found in the supernatants of both Th1 and Th2 clones. The effect of human IL-10 (h-IL-10) and viral IL-10 (v-IL-10) on the | [
-0.0254532,
-0.025774417,
-0.016510531,
-0.035924863,
0.011351794,
0.017461333,
-0.030348541,
0.013414004,
-0.03356071,
-0.02057071,
0.003356713,
0.0032410752,
-0.011358218,
0.007034643,
-0.0015265818,
-0.0083259335,
0.022382371,
-0.015739612,
-0.015264211,
0.002847585,
-0.029654713,
0.023924211,
0.007998292,
-0.019876882,
-0.019080264,
0.008936245,
0.02536326,
-0.04152688,
-0.022665042,
-0.0017136905,
0.019671302,
0.0025520658,
-0.03687566,
0.013825161,
-0.008165325,
-0.029629016,
-0.0014888388,
0.002614703,
0.021572905,
-0.0011330915,
0.017332846,
0.010413841,
0.0077605923,
0.005775474,
-0.0002973261,
0.016279256,
0.022806376,
-0.0087499395,
-0.0021762424,
0.020442223,
0.015778158,
0.017923884,
-0.016600473,
0.0073944055,
-0.0336378,
-0.026108483,
0.01282939,
0.00007935053,
0.0008215114,
-0.023692934,
-0.011326096,
-0.0013627614,
-0.0093474025,
0.002748008,
0.0011346976,
0.011261853,
-0.0067712455,
0.015996585,
0.008178174,
-0.0168189,
0.028138572,
0.0403448,
-0.016895993,
0.014596081,
0.0135039445,
-0.0042336346,
0.0037261122,
0.0022726073,
-0.008358056,
-0.008801335,
0.019157356,
-0.024039848,
0.013112061,
0.011795073,
0.01758982,
0.0071502808,
0.0036811419,
0.01595804,
-0.012945028,
-0.011595919,
0.02739335,
0.011859316,
0.03440872,
0.04296593,
-0.025106287,
0.021560056,
0.0076321056,
0.028652519,
-0.015148574,
-0.021495814,
-0.023667237,
-0.014210621,
-0.01336261,
-0.0070860377,
-0.04401952,
-0.011885013,
0.007304465,
0.002418761,
0.018823292,
-0.01836074,
-0.02555599,
0.025877208,
-0.0035751404,
-0.04283744,
0.032250144,
0.008615028,
0.009379524,
-0.0030884973,
-0.015302758,
0.0030579818,
0.022639344,
0.033483617,
0.002711068,
-0.017371392,
0.029397741,
0.010227536,
-0.008492966,
-0.006552818,
-0.033303734,
0.008981216,
0.02374433,
-0.0029632228,
0.01004123,
0.01364528,
-0.008762788,
0.0046769134,
-0.010079776,
-0.013118485,
0.010580874,
-0.010484509,
0.003043527,
0.012360414,
0.019851184,
0.015328455,
0.0035815649,
0.008518663,
0.028035782,
0.0057626255,
0.008229569,
0.01787249,
-0.017692609,
-0.027881598,
0.017564122,
0.028395545,
0.011981378,
0.02970611,
-0.01557258,
0.021200294,
-0.025311867,
-0.0048921285,
0.0061320243,
-0.01662617,
0.0127266,
0.01364528,
0.018116616,
0.03248142,
0.0010608177,
0.007137432,
0.001337867,
0.012379687,
-0.017255755,
-0.0034627146,
-0.02181703,
0.03708124,
-0.014377654,
0.01778255,
-0.009006913,
0.013568188,
-0.0028732822,
-0.022999106,
-0.008717818,
0.03235293,
0.02288347,
0.0026693097,
-0.01604798,
-0.014043589,
0.019478573,
0.005361105,
-0.012700903,
0.003334228,
0.011557372,
0.010253233,
0.011640889,
-0.01595804,
-0.63030404,
-0.028112875,
0.016266407,
-0.0083773285,
0.000057517842,
0.01816801,
0.006816216,
-0.0046833376,
-0.029937385,
0.022600798,
-0.0042946655,
0.025067741,
0.010831423,
-0.03083679,
-0.018052371,
-0.04576694,
0.014621778,
-0.019067416,
0.013221274,
-0.008338782,
-0.0067905183,
-0.019658454,
0.0023786088,
0.03959958,
-0.0048921285,
0.0033791985,
0.02718777,
-0.015739612,
0.0031559528,
0.045587055,
0.009231765,
0.036567297,
-0.004416728,
0.0010503782,
0.04247768,
0.009636497,
-0.004050541,
0.01278442,
0.018219404,
0.020840531,
-0.005833293,
-0.00600675,
-0.013047817,
0.006263723,
-0.02432252,
0.0131313335,
-0.0019819064,
0.033766285,
0.014197772,
-0.009077581,
0.004590185,
-0.019041719,
-0.0015362182,
0.010972758,
-0.0024846103,
-0.007734895,
0.030451331,
-0.015598277,
0.0066941534,
-0.002362548,
-0.0067391237,
0.023731481,
-0.013157031,
-0.00965577,
0.0076321056,
0.00465764,
0.02190697,
-0.0073494352,
-0.004696186,
0.0010664391,
0.006543182,
0.03515394,
0.019234449,
-0.012501749,
0.0058397176,
0.022626495,
0.014390502,
-0.01268163,
0.012296171,
0.009244613,
-0.01355534,
-0.010503782,
-0.02066065,
-0.013606735,
0.0012961089,
-0.018039523,
-0.0069125807,
0.03543661,
-0.008717818,
0.0075999843,
0.01892608,
0.0032507118,
-0.017911036,
-0.048567947,
-0.033663496,
0.028035782,
0.0008616635,
0.0020092097,
0.0044681225,
-0.013073514,
0.0015884159,
0.010683663,
0.0074650734,
0.010780028,
0.03083679,
0.016459137,
-0.027855901,
0.016099375,
0.041886643,
-0.028035782,
0.030040175,
0.00379678,
-0.008929821,
-0.017538425,
0.01518712,
-0.01719151,
0.020981867,
0.014390502,
0.013863707,
-0.021804182,
0.025299018,
-0.015277061,
0.018669108,
0.011570221,
0.018579166,
0.02153436,
-0.007368708,
-0.025504597,
0.016420592,
-0.00797902,
-0.0018389649,
0.020879077,
0.027521836,
-0.031170856,
0.019041719,
0.018026674,
0.04651216,
0.0022918803,
0.011833618,
-0.010529479,
-0.021354478,
-0.012688055,
0.0020589982,
-0.01643344,
0.014827357,
-0.0066299103,
-0.007131008,
-0.011807921,
0.011904286,
0.0033952591,
0.018694805,
-0.010580874,
0.008467269,
-0.0035879891,
0.007439376,
-0.014005043,
-0.0011531675,
-0.025967147,
-0.009508011,
-0.019864034,
-0.014775963,
0.017615518,
0.006453241,
0.0068740346,
-0.015341303,
-0.009687892,
-0.0105680255,
0.021984063,
-0.006009962,
-0.0394197,
-0.002343275,
0.0074458,
-0.0031350737,
0.0024332155,
0.012174108,
0.0147245675,
-0.01720436,
-0.011750102,
-0.00005581138,
0.004172603,
-0.014878752,
0.022163944,
-0.001784358,
0.001199744,
0.02287062,
0.0015330061,
0.024194032,
0.003992722,
0.0041244207,
0.048002604,
-0.02537611,
-0.0016976296,
-0.0029021918,
0.032455724,
0.024091244,
-0.014763114,
0.016985932,
0.01336261,
-0.0042914534,
0.004670489,
-0.010124747,
0.0026211273,
-0.0029102222,
-0.0067969426,
0.0066299103,
-0.017075874,
-0.006360088,
-0.02824136,
0.003938115,
0.012970725,
0.009244613,
-0.013889405,
0.0051426776,
-0.004378182,
0.027573232,
0.009450192,
-0.009321705,
0.004105148,
0.015508336,
-0.01978694,
0.0035173215,
0.013915102,
0.03212166,
-0.0139536485,
0.00009651554,
0.01211629,
-0.000726351,
-0.0001615117,
-0.01797528,
-0.0013426853,
-0.0066748806,
-0.026699523,
0.013426852,
0.0061352365,
0.007098886,
0.013760918,
-0.000006543533,
-0.020210948,
0.030990975,
0.016806051,
0.0057465644,
0.0026436124,
-0.00028447743,
-0.0033117428,
0.0038481746,
-0.0028572215,
0.024746524,
-0.0054799546,
-0.011756526,
0.04258047,
-0.021752786,
0.0015852038,
0.013748069,
-0.004635155,
-0.005055949,
0.011191186,
-0.01797528,
0.011146215,
0.035899166,
0.014249167,
0.012912907,
-0.014467594,
0.0023079412,
-0.0039220545,
-0.013735221,
0.0069768243,
-0.019812638,
-0.015302758,
-0.0066556074,
-0.009495162,
-0.02826706,
0.0031527407,
0.02565878,
-0.031325042,
0.020121006,
0.0023529115,
0.016292104,
0.00759356,
0.011383915,
0.003877084,
-0.026493942,
-0.02826706,
0.003430593,
0.018579166,
-0.00039088042,
-0.014788811,
-0.0288324,
-0.0077477437,
0.0024781858,
0.019452875,
-0.01787249,
0.007227373,
0.028498335,
-0.011602343,
0.004480971,
0.01167301,
0.041886643,
-0.0172943,
0.013786616,
0.0045452146,
0.013606735,
-0.020313736,
-0.016754657,
-0.0023962758,
0.045021717,
0.00836448,
0.0065656668,
-0.020455072,
-0.009848501,
-0.008094658,
0.001607689,
-0.011897862,
-0.0074136783,
0.017988129,
0.029166466,
-0.006475726,
0.00682264,
0.0064275437,
0.012469628,
-0.0022180004,
-0.007734895,
-0.035051152,
0.008229569,
0.013773766,
0.011814346,
0.010304628,
-0.006453241,
0.00027283333,
-0.01119761,
0.009385948,
-0.021611452,
-0.00430109,
0.019966822,
-0.016009435,
-0.014531838,
-0.010773604,
0.0024300034,
-0.023949908,
0.014184924,
0.008049687,
0.014634627,
-0.009109702,
0.016163617,
0.013073514,
0.006180207,
0.017705457,
0.009430919,
0.03399756,
0.023024805,
-0.014313411,
-0.0006930248,
0.008582907,
0.0062155407,
-0.026519641,
-0.0071502808,
0.03582207,
0.004943523,
0.011249005,
0.0061063273,
-0.017564122,
-0.0076835006,
0.014043589,
0.0053707412,
-0.021868424,
0.007959747,
0.025581688,
0.011377491,
-0.011300399,
-0.010266081,
0.019054567,
-0.010002684,
0.01711442,
0.0045612752,
-0.020300888,
0.0058397176,
-0.024720827,
-0.0036779298,
-0.021058958,
-0.010021958,
0.0023529115,
-0.007304465,
0.0062508746,
-0.008428723,
0.004558063,
-0.023911363,
-0.024078395,
0.02960332,
-0.0044616982,
-0.00883988,
-0.019671302,
0.009257462,
-0.014596081,
-0.010998456,
-0.036592994,
0.00581402,
-0.024656584,
0.0061095394,
0.0158681,
0.00975856,
0.006360088,
0.0026725219,
-0.019594211,
0.018103765,
0.013246971,
-0.03507685,
-0.014197772,
0.015880948,
-0.028626822,
0.019928277,
0.01027893,
-0.0063279667,
-0.020262342,
0.002404306,
-0.023461659,
-0.0059553552,
-0.010099049,
0.022163944,
0.0007090856,
-0.008454421,
0.029269254,
0.025119137,
0.030245753,
0.0057272916,
-0.016883142,
-0.041938037,
-0.004882492,
-0.02594145,
0.0085250875,
0.003427381,
-0.0044070915,
0.018900383,
0.013722372,
-0.02335887,
-0.0048054,
0.029757503,
-0.012071319,
-0.008570058,
0.0052711642,
0.014313411,
0.04191234,
0.007946898,
-0.0099191675,
0.0192216,
-0.022176793,
-0.020622104,
-0.020981867,
0.037363913,
0.01575246,
-0.029526228,
-0.017538425,
0.010972758,
-0.012810117,
-0.009334554,
0.0033952591,
-0.026365457,
0.00039830856,
0.01585525,
-0.006058145,
-0.027007889,
-0.008088233,
0.002523156,
0.023615843,
0.0018759049,
-0.008621453,
0.0027431895,
0.012752298,
-0.009912743,
0.015701067,
0.026224121,
-0.034203142,
-0.025119137,
0.03777507,
0.010388144,
0.022986257,
-0.0021987276,
-0.0009965744,
-0.034048956,
-0.007285192,
-0.015688218,
-0.03852029,
0.006411483,
-0.01797528,
0.02565878,
0.023525901,
0.03836611,
-0.007439376,
0.01692169,
-0.0000038050362,
0.016484834,
0.0058879,
0.009231765,
0.010908515,
-0.005181223,
0.0016422197,
-0.008313085,
-0.030811094,
0.018090917,
-0.01422347,
0.005052737,
0.020159552,
-0.012469628,
-0.011974954,
0.0019112387,
-0.026057089,
-0.0269051,
0.009822803,
-0.021136051,
0.013349761,
-0.015032936,
-0.0099705625,
0.021264538,
0.0055891685,
0.010972758,
0.010118322,
0.03201887,
-0.020840531,
0.025633084,
-0.0045259413,
-0.015277061,
-0.0036972028,
0.0049499474,
-0.001122652,
0.010580874,
0.032532815,
0.0011130155,
0.0113646425,
0.0015161423,
-0.019722698,
0.004127633,
0.0035012607,
-0.030425634,
-0.017037326,
-0.027881598,
-0.0093474025,
-0.004516305,
-0.024772223,
0.0018502075,
-0.033869077,
0.0051266165,
0.008852729,
-0.014942995,
0.011936408,
-0.022382371,
-0.023757178,
0.06383216,
0.005055949,
0.021136051,
-0.020840531,
0.0061095394,
0.03700415,
0.004827885,
-0.022433765,
-0.01196853,
-0.0015177483,
-0.010593723,
0.019054567,
0.024579491,
0.010336749,
-0.013979346,
0.03440872,
-0.010195415,
0.022549404,
-0.015726764,
-0.0057690497,
-0.008994064,
0.001044757,
-0.028138572,
-0.014968692,
-0.016459137,
0.0062829964,
-0.00927031,
0.014621778,
-0.00855721,
-0.012553143,
-0.0053803776,
0.010837847,
-0.018335043,
0.009681468,
-0.0035751404,
-0.03114516,
-0.017371392,
-0.038417503,
0.0028026146,
0.009296007,
0.0032844394,
0.012546719,
-0.008833456,
0.0015844008,
0.0036297473,
-0.015058633,
-0.008158901,
0.011724405,
-0.009585103,
0.03831471,
-0.012347565,
0.0028813127,
-0.0063215424,
-0.00010148436,
0.007657803,
-0.02249801,
0.011885013,
-0.014673173,
-0.016793203,
-0.005052737,
0.036284626,
0.023101896,
0.00011202428,
0.023782875,
-0.031479225,
-0.00074562395,
-0.02932065,
-0.022112548,
0.0076385303,
-0.034074653,
0.0020204522,
0.011499553,
0.009321705,
0.00075485895,
-0.001280048,
0.016587624,
0.011377491,
0.03988225,
-0.02526047,
0.0064211194,
0.0034177443,
0.0099191675,
-0.011608767,
-0.009090429,
-0.011994227,
-0.016741809,
0.0057305037,
-0.006183419,
-0.026005695,
-0.024258276,
-0.005152314,
0.0074265273,
0.0028042207,
-0.007522892,
0.0039638127,
0.00050872675,
0.016343499,
0.0018855412,
-0.0026291576,
0.016394895,
-0.021752786,
-0.01760267,
0.009084005,
0.004146906,
-0.009739286,
0.00027383713,
0.005460682,
-0.0025135197,
-0.0009210885,
-0.03356071,
-0.014262016,
0.008178174,
-0.012411809,
0.0015988555,
-0.015148574,
0.015007239,
-0.015289909,
0.019889731,
0.0049692206,
0.002343275,
-0.030477028,
0.02439961,
-0.011351794,
0.02729056,
-0.013773766,
-0.021919819,
0.006841913,
-0.015444093,
-0.026982192,
-0.012032773,
-0.005229406,
0.02826706,
-0.011942833,
0.0058268686,
-0.019761244,
-0.010677239,
-0.04353127,
-0.0049242503,
0.01383801,
0.0010841059,
-0.0000162114,
0.027316257,
-0.035410915,
0.006668456,
-0.01072221,
0.010561601,
-0.021996912,
-0.02288347,
-0.0016928114,
0.0069703995,
0.019632757,
0.0039638127,
-0.0187462,
-0.025029195,
0.031838987,
-0.00965577,
-0.019016022,
0.030502725,
-0.026596732,
0.0103431735,
-0.024733676,
0.031582013,
-0.0139536485,
0.008293812,
0.0031912867,
-0.03574498,
-0.0062862085,
-0.003041921,
0.006337603,
-0.0074329516,
-0.00608063,
-0.018039523,
0.009289583,
-0.0009636497,
-0.004551639,
-0.0576648,
-0.01854062,
-0.007946898,
0.015534034,
0.03438302,
-0.008672847,
0.012154835,
-0.015212817,
-0.005293649,
-0.0017554486,
0.003024254,
0.011133366,
0.0025536718,
0.014429049,
0.012919331,
-0.011974954,
0.019529969,
-0.0031511346,
-0.015212817,
0.0076256813,
0.003938115,
0.009276735,
-0.027239166,
-0.007439376,
0.020789137,
-0.019684153,
0.0074971947,
-0.009630073,
-0.012373262,
-0.018155161,
0.008769212,
-0.011897862,
0.0046447916,
-0.027881598,
0.006180207,
-0.015174271,
-0.01134537,
-0.024939256,
0.00053562864,
-0.023680085,
-0.00035112986,
0.18995464,
-0.012328292,
-0.021495814,
0.013349761,
0.011107669,
0.0048567946,
0.0010431508,
-0.0042336346,
0.0005910385,
-0.007696349,
0.004166179,
-0.0043653334,
0.0052358303,
0.0037742949,
0.010786452,
-0.024168335,
-0.02066065,
-0.005810808,
-0.020133855,
-0.006880459,
0.000320012,
-0.006408271,
0.031479225,
-0.008062536,
0.046178095,
0.005675897,
-0.030631213,
0.023872815,
0.018489227,
0.0085250875,
-0.03921412,
0.012238352,
-0.0029937385,
-0.0048921285,
0.015277061,
0.019401481,
-0.0062894206,
-0.0127073275,
-0.0007905943,
-0.011576645,
-0.019350087,
0.0006918202,
-0.029449135,
-0.008884851,
0.007343011,
0.023770027,
-0.0076385303,
-0.0028443728,
-0.0129321795,
-0.0119107105,
-0.016510531,
-0.014660325,
0.016690413,
0.026082786,
0.01162804,
-0.0025135197,
0.043659758,
0.0020879076,
-0.0064564534,
0.026750917,
-0.006610637,
0.0044070915,
-0.04114142,
0.01403074,
-0.023770027,
0.012418233,
-0.008223144,
-0.0051073437,
-0.0025681264,
-0.0326613,
0.02229243,
-0.00806896,
-0.012675206,
-0.0011001668,
-0.0038192652,
-0.01162804,
0.00038285,
0.024039848,
0.012662358,
0.016420592,
0.011647313,
0.030734003,
-0.03212166,
0.010702936,
0.013259821,
-0.0061063273,
0.029192163,
0.009482313,
-0.037209727,
0.0052647395,
0.005846142,
0.0011186367,
-0.023037653,
-0.003427381,
0.0034948364,
-0.0063279667,
-0.020455072,
0.0025488536,
-0.008306661,
-0.026956495,
-0.0035590797,
0.0662991,
0.018000977,
0.0192216,
-0.0172943,
0.023294626,
-0.001434232,
-0.0058204443,
-0.013850858,
-0.012456778,
0.033689193,
-0.030631213,
0.011762951,
-0.002420367,
0.008518663,
0.020223796,
0.001278442,
-0.009276735,
0.0127330255,
-0.007053916,
0.0059617795,
-0.030682607,
-0.011859316,
0.019427178,
-0.009385948,
0.012219079,
-0.016574776,
0.021110354,
0.011454583,
-0.018180858,
0.0069639753,
-0.014955844,
0.0016012646,
0.03294397,
0.03595056,
0.001532203,
0.0154954875,
-0.023371719,
-0.036181834,
0.0059649916,
-0.0060999026,
-0.008280964,
0.0057594134,
-0.030297147,
0.008589331,
-0.011608767,
0.033612102,
0.004901765,
-0.013542491,
-0.013124909,
-0.0158681,
-0.008036839,
-0.0080047175,
-0.019157356,
0.0075036194,
-0.012148411,
-0.012867936,
-0.017127268,
-0.0067969426,
-0.009283159,
-0.015456942,
0.038571686,
0.016985932,
-0.00079179887,
-0.027521836,
-0.0050238273,
-0.1585011,
-0.0046447916,
0.020442223,
-0.015803855,
0.02153436,
0.010484509,
-0.006552818,
-0.023089048,
-0.0021184233,
0.016895993,
0.044893228,
0.006568879,
-0.04296593,
-0.008255266,
-0.00069703994,
-0.009071156,
-0.033303734,
0.033971865,
-0.000582205,
0.010458812,
0.042246405,
-0.013060666,
-0.00005651404,
-0.025003498,
0.02027519,
0.0074907704,
0.004008783,
0.0056694727,
0.008120355,
-0.027316257,
0.0034659267,
0.019542817,
0.032738395,
-0.0053739534,
0.012090592,
0.0007231388,
0.01748703,
-0.014454746,
0.0016735384,
0.012668782,
0.022703588,
0.012219079,
-0.0047218837,
0.010118322,
-0.026596732,
0.029834596,
0.0025119137,
0.003271591,
0.031787593,
-0.013516794,
0.016639018,
-0.015778158,
0.03240433,
0.0031736197,
0.014570384,
-0.0087499395,
0.00946304,
0.023307474,
-0.005807596,
0.02057071,
-0.015045784,
-0.029243557,
0.026185576,
-0.009193218,
-0.012039198,
-0.018951777,
-0.014853055,
0.017744003,
-0.0069447025,
0.0050848583,
-0.035976257,
-0.0065977885,
0.020981867,
-0.019157356,
0.007792714,
0.009854925,
-0.019966822,
0.008332358,
0.034562904,
-0.0035976255,
-0.017448485,
0.012007075,
-0.021727089,
0.0035815649,
-0.03325234,
0.017063025,
-0.0052775885,
0.04103863,
-0.010548753,
-0.0073494352,
0.004313939,
-0.015302758,
-0.012623811,
-0.017499879,
0.010593723,
0.033123855,
0.003271591,
0.0060356595,
0.011769376,
0.012141987,
0.027907297,
-0.01941433,
-0.009283159,
0.010587298,
0.03875157,
-0.00740083,
-0.047154594,
-0.0028347364,
0.031684805,
0.002712674,
0.0016815688,
0.0225751,
-0.0029182525,
0.024643736,
-0.0089490935,
0.046383675,
-0.026416851,
-0.009456616,
-0.0004894538,
-0.030605515,
0.06707002,
-0.0015161423,
-0.018874686,
0.005714443,
-0.032918274,
-0.030862488,
-0.14082135,
-0.036079045,
0.0211489,
-0.0003918842,
-0.014827357,
0.0216243,
-0.0024669433,
0.04545857,
-0.013825161,
0.021791333,
-0.023320323,
0.0006548803,
-0.0045869728,
-0.016934538,
0.0025119137,
0.013979346,
0.0057465644,
-0.016844597,
-0.023166139,
0.029500531,
0.0103431735,
-0.0015410365,
-0.017654063,
-0.017769702,
0.010054079,
-0.011461007,
-0.03027145,
0.019876882,
0.013349761,
0.014788811,
0.012675206,
-0.008178174,
0.012964301,
0.0043653334,
-0.0035815649,
0.009842076,
-0.02181703,
-0.020647801,
0.041732457,
-0.003893145,
-0.0067969426,
0.002264577,
0.0036650812,
-0.015032936,
0.033689193,
-0.008248841,
-0.019735547,
-0.030811094,
0.009874198,
-0.028035782,
-0.036978453,
-0.033432223,
-0.03633602,
0.0003418949,
-0.0061063273,
0.009366675,
0.019876882,
0.01624071,
-0.017615518,
0.0022196064,
0.006533545,
-0.00059344765,
-0.021585753,
0.00083998137,
0.033869077,
-0.013786616,
-0.00021822652,
-0.024142638,
0.030811094,
-0.024823617,
-0.009071156,
0.013915102,
-0.029911688,
-0.028755307,
-0.0020589982,
0.01336261,
-0.018090917,
-0.020519314,
0.028472638,
-0.020519314,
-0.026442548,
-0.011249005,
0.013079939,
0.0047186716,
0.040036432,
0.009039034,
0.008370904,
-0.01134537,
-0.019260146,
-0.01287436,
-0.021110354,
0.04055038,
0.0049949177,
0.0037903555,
0.006893308,
0.006899732,
-0.038417503,
-0.00778629,
0.03065691,
0.0030901034,
-0.017718306,
-0.036567297,
-0.04977572,
0.012816542,
-0.015701067,
-0.007754168,
0.0074650734,
-0.0030547697,
0.012610963,
-0.021110354,
0.012437506,
0.002344881,
-0.012970725,
0.0007058734,
-0.029731806,
0.009964138,
0.0054928036,
-0.001610098,
0.01643344,
-0.010060503,
0.02055786,
0.00778629,
-0.0025263685,
-0.0067519723,
0.005987477,
0.011814346,
-0.018566318,
0.008627878,
-0.0008937851,
0.012463203,
-0.007131008,
-0.00860218,
0.0037229,
-0.03294397,
-0.019260146,
0.008672847,
-0.029500531,
-0.027984388,
-0.0010126353,
0.037363913,
0.013735221,
0.016870294,
0.0055731074,
-0.034331627,
0.009135399,
0.0014494898,
0.0032587422,
-0.0052004964,
-0.050109785,
0.011409612,
0.008107507,
-0.0027913721,
0.06455168,
0.0032458934,
0.0045034564,
-0.049158983,
-0.025825813,
0.00031338693,
0.0068354886,
-0.03201887,
0.010985607,
-0.012032773,
0.015623975,
0.010323901,
0.004770066,
0.021110354,
-0.00519086,
-0.016716111,
-0.017641215,
-0.019465724,
0.008762788,
0.01480166,
-0.006957551,
0.009739286,
0.0058043837,
0.0024942467,
0.012655933,
0.01355534,
-0.008370904,
0.019362936,
-0.012488901,
0.01911881,
-0.00530971,
-0.000058672216,
-0.025234774,
0.027701717,
0.04682053,
0.0297832,
-0.0006745548,
0.027907297,
0.0055698953,
-0.0049274624,
0.011461007,
0.006784094,
0.015726764,
-0.0050687976,
0.020133855,
0.004281817,
-0.012039198,
0.011660161,
0.0004978857,
0.051985692,
0.0029792837,
-0.018502075,
0.009212491,
-0.013812313,
-0.016215013,
0.012623811,
-0.042734653,
-0.040961538,
-0.04162967,
-0.016022284,
0.0025793691,
-0.0037164758,
-0.0008696939,
-0.00007177183,
-0.03037424,
-0.01692169,
-0.016651867,
0.020622104,
-0.011069124,
0.020480769,
-0.00079942774,
0.0026693097,
-0.006221965,
-0.006893308,
0.0070217946,
0.011762951,
0.020647801,
-0.009578678,
0.0045612752,
0.013285518,
0.018887535,
-0.00082472357,
-0.016253559,
-0.027033588,
-0.017538425,
-0.009071156,
0.018142313,
0.025800114,
-0.0011065911,
0.0788394,
0.0097457105,
-0.023705782,
0.0005500834,
-0.013259821,
0.0070217946,
0.010458812,
0.023949908,
-0.007201676,
-0.025131986,
0.022652192,
-0.013619583,
0.0471032,
-0.044970322,
-0.038006347,
-0.0037164758,
-0.013722372,
-0.008730667,
-0.02247231,
0.0019851185,
-0.0001950387,
-0.006957551,
-0.020814834,
0.0059971134,
-0.03384338,
-0.0021248476,
0.042040825,
0.005483167,
-0.006880459,
-0.03353501,
-0.0009748923,
-0.005846142,
-0.05411857,
-0.011126942,
-0.00360405,
-0.026519641,
-0.011936408,
-0.013683826,
0.01816801,
0.023525901,
-0.0012704115,
0.0076385303,
-0.024579491,
-0.023461659,
0.010021958,
-0.03440872,
-0.02441246,
-0.011081972,
-0.0225751
] |
OBJECTIVE To assess the efficacy of various controlled ovarian hyperstimulation (COH) regimens in the prior poor-responder patient preparing for assisted reproductive techniques. DESIGN English-language literature review. PATIENT(S) Candidates for assisted reproductive techniques who had been defined as having a prior suboptimal response to standard COH regimens. INTERVENTION(S) A variety of regimes are reviewed, including increased gonadotropin doses, change of gonadotropins, adjunctive growth hormone (GH), luteal phase (long) GnRH agonist (GnRH-a) initiation, early follicular phase (flare) | [
-0.039373692,
0.0034158656,
0.016098738,
-0.009884352,
0.0025188385,
0.02712228,
0.016221525,
-0.0040110415,
-0.039128117,
-0.021092076,
-0.0033408292,
0.01251745,
0.003690431,
0.018936481,
-0.007148931,
0.007408148,
0.047941495,
-0.010934863,
0.0050172126,
0.0120263025,
-0.024011677,
0.005082017,
-0.015402945,
0.0027268943,
0.0088201985,
-0.020832859,
0.005378752,
-0.039837554,
0.010007139,
0.002989522,
-0.016398884,
0.0035608225,
-0.0024114,
-0.0068556066,
-0.02720414,
-0.03435307,
-0.00045405602,
0.0017121963,
0.013390603,
-0.010464179,
0.025935339,
-0.005982455,
0.0019765294,
0.01738118,
-0.0055527003,
0.0017139016,
0.0061427597,
-0.034243926,
-0.00391213,
0.043712165,
-0.011535155,
0.018499905,
-0.026903993,
0.019577703,
0.0031088982,
0.014993655,
-0.004263437,
0.028022718,
0.019345772,
-0.03972841,
-0.012926741,
-0.0007094359,
-0.019986993,
0.04081985,
-0.0074695414,
0.020491783,
-0.0021078433,
-0.008240371,
-0.0024693827,
-0.0066953013,
0.027258711,
0.013943144,
-0.030751318,
0.010962149,
0.027231425,
-0.008056191,
-0.0319519,
0.0019662972,
0.034434926,
0.017899614,
0.026058126,
-0.0010982613,
0.009700172,
0.023629673,
-0.007681008,
0.013254173,
0.0046931915,
0.027613427,
0.01260613,
-0.016126024,
-0.0022971397,
0.01187623,
0.033343486,
0.025566978,
-0.00026966239,
0.019263914,
0.011146329,
0.018117901,
-0.0042156866,
-0.018609049,
-0.0079129385,
-0.0051706964,
-0.02043721,
-0.023588743,
-0.026863063,
0.00063653116,
0.009434133,
-0.0025290707,
0.015553018,
0.0001833278,
0.0011042302,
0.050615523,
-0.015894093,
-0.014625294,
0.011760265,
-0.00047153613,
0.0077355797,
0.009925281,
-0.024407323,
-0.009318167,
0.012687989,
-0.016658101,
0.025184974,
-0.015130085,
0.024502825,
0.00084586587,
-0.024734756,
-0.00011703134,
0.00655205,
-0.005730059,
-0.004157704,
0.018022401,
0.011930802,
0.004713656,
-0.027681643,
0.005296894,
-0.020942003,
-0.011303224,
-0.026481058,
-0.021187576,
0.0049251225,
0.020177994,
-0.017681325,
0.016644457,
-0.023629673,
0.017067391,
0.034516785,
0.014352434,
0.001317402,
0.014434292,
-0.008492766,
-0.010702932,
-0.008165334,
0.012790311,
0.017804112,
0.019304842,
0.027872644,
0.030887747,
-0.004290723,
-0.010750682,
0.0115692625,
-0.0027592964,
-0.002334658,
0.0056823087,
-0.0035096612,
-0.0106483605,
0.024420967,
-0.0018179294,
0.012278698,
-0.01884098,
-0.004236151,
0.0070466087,
-0.036917955,
0.0044578495,
-0.007708294,
0.016126024,
0.0060506696,
0.0053855735,
-0.00914763,
-0.042238723,
-0.025921697,
0.0033101323,
0.017176535,
0.023684245,
-0.024325466,
0.02407989,
-0.0051945713,
-0.003513072,
-0.010702932,
-0.01738118,
0.0007094359,
0.008772448,
-0.010341393,
-0.010095819,
-0.63783747,
-0.02079193,
-0.007162574,
-0.004345295,
0.013438353,
0.021665081,
-0.002743948,
-0.0064667813,
-0.0263992,
0.017121963,
-0.022319945,
0.028432008,
-0.014502507,
-0.011050829,
0.012776668,
-0.034434926,
-0.006534996,
-0.010382322,
0.01465258,
-0.0013361612,
-0.0017923489,
-0.016330669,
-0.003963291,
0.026521988,
0.03309791,
-0.0014435997,
0.01679453,
0.0006271516,
0.008867948,
0.008063012,
0.011098579,
0.03326163,
-0.0061905105,
0.012435593,
0.05811917,
0.00054955704,
-0.007749223,
-0.0013310451,
0.00139926,
0.06466781,
-0.013458817,
-0.012203662,
0.03394378,
-0.013281459,
-0.029687164,
0.024925757,
0.008206263,
-0.03154261,
0.008226728,
-0.00007972627,
0.022047086,
0.007571864,
0.0030867283,
-0.009543277,
0.0035335366,
0.0024352751,
-0.0034005174,
-0.0068419636,
-0.013008599,
0.021173934,
0.015321087,
0.016548956,
-0.038009394,
-0.014911797,
-0.008329051,
0.027845358,
-0.00869059,
0.013458817,
-0.0035233044,
-0.0056175045,
0.0083563365,
0.018609049,
-0.009127166,
0.0044169207,
0.0041338284,
0.03517165,
0.0059040072,
0.013533854,
0.0024199267,
0.0011630655,
0.0055220034,
0.010914398,
0.0036563235,
0.0046488517,
0.0092772385,
-0.03129704,
-0.032497622,
0.012626595,
-0.011698871,
0.0020549765,
0.0028650295,
0.015143728,
0.0074149696,
-0.00809712,
0.0050888383,
0.014175075,
0.00088338414,
0.0035505902,
0.0063098865,
-0.040355988,
-0.009413669,
0.0014751492,
-0.014393363,
0.027231425,
-0.0027695287,
0.0020754412,
-0.02848658,
0.013554319,
0.02416175,
-0.023329526,
0.008642839,
0.00045362968,
-0.0060131513,
-0.00017906434,
0.009168095,
-0.032988768,
-0.013540676,
0.02024621,
-0.015866807,
-0.027790787,
0.03440764,
-0.037108954,
0.01001396,
-0.0007038934,
0.008178977,
0.016658101,
-0.017503968,
-0.02835015,
-0.020368997,
0.0022783808,
0.011487405,
-0.014543436,
0.0037381814,
-0.024216322,
0.020287137,
-0.0021743528,
0.007653722,
-0.017012818,
0.013813536,
-0.021869726,
-0.018499905,
-0.008404087,
0.021515008,
-0.008636018,
0.0071966816,
-0.014584365,
-0.0143115055,
0.011732979,
0.0045362967,
-0.0010343097,
-0.0011929097,
-0.032279335,
-0.011541977,
0.0039189514,
-0.024748398,
-0.0074422555,
-0.020259852,
-0.02010978,
-0.0090453075,
-0.019946063,
0.030505743,
0.0016874684,
-0.030969605,
-0.022483662,
-0.02106479,
-0.02334317,
-0.0030492102,
0.007435434,
-0.021746939,
-0.033643633,
0.017121963,
-0.027708929,
-0.01451615,
0.03440764,
-0.008888413,
0.016712673,
-0.01051193,
-0.027831716,
-0.015730377,
-0.002735421,
0.000118310374,
0.0001991025,
-0.028050004,
0.0017249866,
0.016917318,
-0.0010709753,
0.00030547526,
0.010668824,
-0.010573324,
0.011084936,
0.0073876833,
0.01907291,
0.014666223,
0.023534171,
-0.010498287,
-0.01697189,
0.00035621016,
0.013008599,
-0.0023517117,
0.03320706,
0.06052034,
-0.006262136,
0.021910654,
0.0058221496,
0.028404722,
0.0071148234,
0.004123596,
-0.012913098,
0.022224443,
-0.01165112,
-0.0018571531,
-0.0045192433,
-0.000452777,
0.0034073389,
0.013083635,
-0.0037108955,
0.007987975,
0.016439812,
-0.0018537424,
0.013124564,
-0.006026794,
-0.0026450362,
0.030942319,
-0.0023670602,
-0.031242466,
0.016221525,
0.023425028,
-0.008213085,
0.02043721,
0.01642617,
-0.014857225,
0.026276415,
-0.011582905,
0.010109462,
0.028568437,
0.0033510614,
0.008342694,
-0.016112382,
0.03626309,
-0.00042975444,
0.00031250992,
0.012387842,
0.034189355,
-0.02320674,
-0.008069834,
-0.020355353,
0.022879308,
0.015825877,
-0.015853165,
0.011958088,
0.009891174,
0.01410686,
-0.015362016,
-0.010709753,
-0.006957929,
0.005487896,
-0.0060404376,
0.00400422,
0.029605307,
0.037982106,
0.011848944,
0.010123105,
0.018213402,
-0.011173615,
0.00016137109,
0.019100197,
0.035662796,
0.01201266,
-0.013533854,
-0.012469701,
0.01223777,
0.0032930786,
0.010880291,
-0.009447776,
0.013861286,
0.012633416,
0.015580304,
0.004805746,
0.022006156,
0.003021924,
-0.011453297,
-0.022033442,
0.02193794,
0.014147789,
0.00010152309,
0.02447554,
-0.0110099,
0.0070875376,
-0.0044714925,
0.0068828925,
0.008438194,
-0.017217463,
-0.002078852,
-0.020942003,
-0.008711054,
-0.022729235,
0.016071452,
-0.0017735898,
0.02234723,
-0.015171014,
-0.003013397,
-0.013349674,
0.0023551225,
-0.012667524,
0.0077151153,
0.00933181,
-0.0131723145,
-0.03699981,
-0.007967511,
-0.014038645,
0.035717368,
0.0021061378,
-0.005068374,
0.011985374,
0.013758964,
0.0007414117,
-0.02106479,
0.003067969,
0.033234343,
-0.0031754079,
0.008445016,
0.004154293,
0.006548639,
-0.014352434,
0.026126342,
0.030860461,
0.011003078,
0.021774225,
0.025307762,
0.010252713,
-0.011753443,
-0.026535632,
0.0192912,
-0.0019338949,
0.0037381814,
0.0021999334,
-0.009638778,
-0.0053310017,
-0.010566502,
0.013458817,
-0.000713273,
-0.0028735565,
-0.0052116252,
-0.00279852,
0.0043214196,
0.00860191,
0.022947524,
0.020873787,
0.014420649,
-0.034735072,
0.018486263,
0.023861604,
0.010034425,
-0.0012184903,
-0.035962943,
0.00732629,
-0.0037791105,
0.023697888,
-0.0024011678,
-0.007380862,
0.0069920365,
-0.034926075,
0.00841773,
-0.016112382,
0.018104259,
0.014025002,
0.010443715,
0.014570722,
0.0136361765,
-0.018390762,
0.015853165,
0.023998033,
-0.013554319,
-0.019905135,
0.011623834,
-0.011159972,
-0.01779047,
0.009379561,
-0.014025002,
-0.020191638,
-0.024243608,
-0.01410686,
0.012960848,
-0.023602387,
-0.025676122,
-0.021460436,
0.005433324,
-0.009979853,
-0.031460755,
-0.03317977,
-0.020669142,
-0.026781205,
0.0025188385,
-0.0045362967,
-0.01734025,
-0.022047086,
-0.02116029,
0.03148804,
0.012353735,
0.022961166,
0.008772448,
0.021037502,
0.009475063,
0.009563741,
-0.02088743,
-0.025826195,
0.0030509154,
-0.01888191,
0.015280158,
-0.0067294086,
0.007230789,
-0.015280158,
-0.021733295,
0.027708929,
0.00718986,
-0.025635194,
-0.021542294,
-0.014352434,
-0.009543277,
0.014229647,
0.021133004,
-0.010757504,
-0.004918301,
-0.026521988,
-0.010198141,
-0.027613427,
-0.002730305,
-0.018786408,
0.0013540676,
0.014884511,
-0.018499905,
0.0136361765,
-0.020600928,
-0.008861127,
0.0069135893,
-0.017544895,
0.0054947175,
0.0046147443,
0.015730377,
0.017408466,
-0.010164034,
0.020150708,
0.011760265,
0.001852037,
0.00034022226,
-0.007012501,
0.024611969,
-0.0067294086,
-0.031242466,
0.012578844,
0.007885653,
0.0019014928,
-0.026863063,
0.0049489974,
-0.008158512,
0.02794086,
0.007108002,
-0.026508346,
-0.034789644,
-0.018022401,
-0.037627388,
0.014488864,
-0.017913256,
-0.013765785,
-0.0039803446,
-0.018581763,
-0.0066236756,
-0.036699664,
0.033234343,
-0.024680184,
-0.004280491,
0.00045362968,
-0.036208518,
0.0028343329,
0.01437972,
-0.0024744987,
-0.028159149,
-0.004191811,
-0.009897995,
-0.044858176,
-0.0022596216,
-0.013151851,
0.021051146,
0.017694969,
0.037872963,
-0.017326608,
-0.015539375,
0.019823276,
-0.001355773,
0.013984073,
-0.009597849,
-0.006835142,
-0.024216322,
0.021924298,
0.0067771594,
-0.026481058,
0.028104575,
-0.02006885,
0.028159149,
0.031242466,
-0.0250349,
-0.02289295,
-0.016548956,
-0.03386192,
-0.020873787,
0.007694651,
0.024325466,
-0.014952726,
-0.035744656,
-0.022047086,
0.010853005,
0.03855511,
0.016685387,
-0.012660703,
0.006320119,
-0.023506885,
-0.008902056,
0.0037518244,
0.005907418,
-0.017463038,
-0.013486104,
-0.0018571531,
0.007203503,
0.011848944,
0.01907291,
0.019482201,
-0.009488706,
-0.02098293,
-0.027340569,
0.013342852,
-0.009932103,
0.008676947,
-0.003908719,
-0.026426487,
0.002170942,
-0.0042020436,
-0.008438194,
0.0012892634,
-0.004764817,
0.01388175,
0.0063235294,
0.0068180882,
-0.013342852,
0.0025171333,
0.011187258,
-0.040683422,
0.014761724,
-0.009188559,
0.033561774,
0.0036460913,
-0.004375992,
0.008567803,
-0.0044714925,
0.0023772924,
0.013342852,
0.02916873,
0.017654039,
0.0108734695,
-0.034926075,
-0.0068999464,
0.009393204,
-0.03508979,
-0.02538962,
0.015553018,
0.020682786,
0.0056720763,
-0.011357796,
-0.022865664,
-0.017817756,
0.031406183,
0.0046897805,
-0.0011298108,
0.005163875,
-0.0032231584,
-0.009072593,
0.035280794,
-0.009625135,
0.0015416588,
-0.012305984,
0.012824418,
-0.017940542,
-0.019209342,
-0.019100197,
0.00969335,
-0.016726315,
0.02603084,
-0.010880291,
-0.00009438184,
0.008001618,
0.0071148234,
-0.0027388318,
-0.008315408,
-0.0028275114,
0.037299957,
0.0050444985,
0.0023738816,
0.031569898,
0.0064326734,
-0.0010445421,
-0.01051193,
-0.0028940209,
0.008172156,
0.0032385066,
0.004058792,
0.026371915,
0.010095819,
-0.047341205,
-0.008001618,
-0.0120194815,
0.0034891968,
-0.0054776636,
-0.020423569,
0.012667524,
-0.042211436,
0.0029230122,
-0.0033101323,
0.0025563568,
0.03844597,
0.011507869,
-0.010368679,
0.009031665,
0.019564059,
-0.034598645,
0.017503968,
0.010361857,
-0.0047989246,
-0.0059449365,
0.024598327,
-0.024953043,
0.0017718844,
0.0035164827,
-0.010027603,
-0.045349326,
-0.0050172126,
0.01679453,
-0.00072094717,
-0.008922521,
0.0013890277,
0.024516467,
0.016112382,
0.0122582335,
-0.008881592,
-0.027722573,
-0.004621566,
-0.001783822,
0.0019321896,
0.026044484,
-0.030915033,
0.012346913,
-0.008615553,
0.031569898,
0.018486263,
-0.03541722,
0.0025137225,
-0.0012440709,
0.012005839,
-0.019495845,
-0.0016763834,
-0.01683546,
-0.02020528,
-0.018813694,
0.0031293626,
0.006708944,
-0.024516467,
-0.029769022,
0.023902534,
0.014939083,
0.0055220034,
-0.021092076,
0.011037186,
0.00090214325,
0.0053685196,
-0.040437847,
0.0017633575,
-0.027995432,
0.041010853,
0.025744338,
-0.03170633,
-0.018145187,
-0.007176217,
-0.044803604,
-0.0057846312,
-0.00002314247,
0.011385082,
-0.01506187,
0.017394822,
0.023056667,
0.009290881,
0.021624152,
0.0127084525,
-0.013915858,
-0.019168412,
0.015375659,
-0.00914763,
0.0250349,
-0.011371439,
-0.031733613,
-0.0029417714,
0.014434292,
-0.011296403,
0.003422687,
0.009195381,
0.01642617,
0.021269433,
-0.008472302,
0.00996621,
-0.018390762,
0.009215845,
-0.010389143,
-0.014352434,
0.007878832,
-0.0014887921,
0.012285519,
-0.006306476,
-0.009515991,
-0.008724697,
-0.012647059,
-0.00025943015,
-0.02161051,
0.0019765294,
0.010996256,
-0.013799893,
-0.016808175,
0.028131861,
-0.0015936727,
-0.003976934,
0.015484802,
0.0016755307,
-0.011869408,
0.005886954,
0.006115474,
0.022169871,
0.01096897,
-0.0060404376,
-0.01993242,
-0.017858684,
0.011862587,
-0.0055595217,
0.0011801193,
-0.0020754412,
0.007612793,
-0.01961863,
0.023697888,
0.003717717,
0.006674837,
0.00028181318,
-0.0012585666,
-0.007653722,
0.003690431,
-0.0030560317,
-0.00172925,
-0.043330163,
0.01660353,
-0.004761406,
-0.020873787,
0.018759122,
-0.009754743,
0.004631798,
-0.0071966816,
0.021651438,
0.19645917,
-0.004079256,
-0.004437385,
0.013711213,
-0.0036733772,
-0.016535314,
0.0335072,
0.020396283,
-0.029223302,
0.0319519,
0.029550733,
-0.013520211,
-0.014120503,
-0.0001007237,
0.029960023,
-0.018991053,
-0.00596199,
-0.012039945,
0.00017288237,
0.0077014724,
0.010737039,
0.014038645,
0.001685763,
-0.011173615,
0.012974491,
-0.0046795486,
-0.008676947,
-0.012183198,
0.013090457,
0.007299004,
-0.009795672,
0.011296403,
-0.0008070686,
-0.018690908,
0.035662796,
0.001988467,
-0.008076655,
-0.0025307762,
-0.009229489,
0.0106551815,
-0.010853005,
0.024748398,
-0.013806714,
-0.0077969735,
0.02006885,
0.018527191,
-0.004727299,
0.0028172792,
-0.013315566,
-0.01619424,
-0.041665718,
0.000822417,
0.010914398,
0.036344945,
-0.008322229,
-0.011391903,
0.041338284,
0.015989594,
-0.03135161,
0.017135605,
-0.014843582,
-0.0015587126,
-0.00076827133,
0.016808175,
0.00049882213,
0.025744338,
-0.023807032,
-0.0071011805,
-0.02307031,
0.027708929,
0.00473071,
0.008983914,
-0.0050751953,
-0.010607431,
-0.019918777,
-0.02143315,
0.025676122,
0.01993242,
0.014325148,
0.034134783,
-0.0010718281,
-0.013295102,
-0.029059585,
0.0014529793,
-0.026426487,
-0.020969288,
0.021815155,
0.01734025,
-0.006889714,
0.012169554,
-0.000098591976,
0.022811092,
-0.021651438,
-0.0085950885,
0.020368997,
-0.0056004506,
-0.00085439277,
-0.0026467417,
0.0019083144,
-0.0090384865,
-0.020368997,
0.074436195,
-0.010361857,
0.0076059713,
-0.0022903183,
-0.014679866,
-0.010586967,
0.016658101,
0.011064472,
0.012074053,
0.023861604,
-0.024393681,
-0.0029451821,
-0.022947524,
-0.007435434,
0.014434292,
0.030505743,
-0.024652898,
0.02161051,
-0.01196491,
-0.009495527,
-0.022470018,
0.0081448695,
0.023820674,
-0.010614253,
-0.0030952552,
-0.014734438,
-0.005948347,
-0.0040076305,
-0.016535314,
0.019536773,
-0.015853165,
-0.007067073,
0.0057402914,
0.01774954,
-0.014134146,
0.0022783808,
0.005839203,
-0.025103116,
0.015921379,
0.01983692,
0.008254014,
0.012735738,
0.0027678232,
0.008663304,
-0.0030611476,
-0.00040268162,
0.010382322,
-0.023056667,
-0.00066552253,
0.001603905,
-0.013185957,
0.016876388,
-0.023506885,
0.01961863,
-0.033725493,
-0.02002792,
-0.025144046,
0.026412845,
0.013138208,
-0.02998731,
0.0023500065,
0.02161051,
0.010689289,
-0.0033050163,
-0.0012415128,
-0.17353894,
0.0016013469,
0.025294118,
-0.018895552,
0.023575101,
0.0017445984,
0.015225586,
0.009209024,
-0.015171014,
-0.0077287583,
0.018349832,
0.029005013,
-0.026467416,
-0.031788185,
-0.00005291991,
0.007974332,
-0.019168412,
0.021351293,
0.005811917,
0.008219906,
0.006289422,
-0.021815155,
0.003990577,
-0.00013152703,
0.00087485724,
-0.0006766074,
-0.0056857197,
0.025635194,
0.006917,
0.0040519703,
-0.030014595,
0.008035726,
0.017026462,
0.01815883,
-0.0134042455,
0.0012687988,
0.005283251,
-0.003717717,
0.0009371034,
0.0165626,
0.012203662,
0.003567644,
0.0031566487,
0.02238816,
-0.008649661,
0.020191638,
0.024243608,
-0.017845042,
0.008329051,
-0.0038575577,
0.011391903,
-0.0068863034,
0.013069992,
-0.004341884,
0.014707152,
0.0042020436,
0.014338791,
0.015730377,
0.002803636,
-0.010498287,
0.0061461707,
-0.023616029,
0.008076655,
0.010491465,
0.011016721,
-0.023738816,
-0.00505132,
-0.023970747,
-0.016685387,
0.009202202,
-0.011016721,
0.010123105,
0.0037006633,
-0.018540835,
0.057409737,
0.012155911,
0.001039426,
0.011091758,
0.026262771,
0.017995115,
-0.024270894,
-0.008178977,
-0.020191638,
-0.015171014,
0.0027422425,
-0.0075036488,
0.014229647,
0.029086871,
-0.0031515325,
0.015457517,
0.014720795,
-0.02024621,
-0.011930802,
-0.0018400993,
-0.001276473,
0.01615331,
-0.020300781,
-0.0030151026,
0.00057684304,
-0.021897012,
0.021815155,
-0.01533473,
-0.0059108287,
-0.0011366323,
0.027135924,
-0.00887477,
-0.019946063,
0.013465639,
0.03549908,
-0.022551876,
-0.01884098,
-0.009993496,
0.00031741287,
0.022770165,
0.0031481218,
0.02739514,
0.0019424219,
-0.00090981746,
0.012967669,
-0.013861286,
0.05855575,
-0.00518775,
-0.019441273,
-0.016180595,
-0.012947205,
-0.013083635,
-0.13108192,
-0.012080875,
0.016999176,
-0.011828479,
-0.016276097,
0.0370271,
0.0036529128,
0.015375659,
-0.043766737,
0.020901073,
-0.019304842,
-0.016221525,
-0.0053889845,
-0.012387842,
0.04081985,
-0.008929342,
0.008711054,
-0.047395777,
0.016139667,
0.032825053,
0.013793071,
-0.013083635,
0.0030065756,
-0.008908878,
-0.006446317,
-0.009338632,
-0.011814836,
0.017967828,
-0.00044552915,
0.017285679,
-0.004171347,
0.016944604,
0.02197887,
-0.011999017,
-0.031842757,
-0.038391396,
-0.030232884,
-0.008861127,
0.015716733,
0.0009268712,
-0.007067073,
-0.0014598008,
0.022674663,
0.001974824,
0.014529793,
0.0033323022,
-0.02316581,
0.005116124,
0.014352434,
-0.013486104,
-0.035635512,
-0.014816296,
-0.020928359,
-0.00211637,
0.0006906768,
-0.021760583,
0.042484295,
0.010389143,
-0.0055731647,
0.03612666,
-0.015853165,
0.033479918,
-0.040928993,
0.009652421,
0.010593788,
-0.0022357462,
-0.01369757,
-0.03631766,
-0.006957929,
0.0064701918,
-0.04081985,
0.023643315,
-0.019359414,
0.012824418,
-0.031051464,
0.005163875,
-0.011071293,
-0.011548798,
0.02402532,
-0.016398884,
-0.0058460245,
-0.011944445,
0.045349326,
-0.028623011,
-0.027968146,
0.008472302,
0.01574402,
-0.038527828,
0.002771234,
-0.03317977,
-0.009004379,
0.016289739,
-0.012394664,
-0.02371153,
-0.0067771594,
-0.01369757,
-0.026808491,
-0.013499747,
0.015948664,
0.024734756,
-0.022088014,
-0.004887604,
-0.057737168,
0.030205598,
0.0133974245,
-0.016276097,
0.0036256267,
-0.019332128,
0.030041883,
0.015280158,
-0.0051706964,
0.016207881,
-0.026412845,
0.001066712,
-0.024243608,
-0.017367536,
-0.033725493,
-0.017067391,
0.012674346,
-0.014939083,
0.0056482013,
0.022047086,
-0.015498446,
-0.0037006633,
0.011732979,
0.016180595,
-0.004205454,
0.013874929,
0.0006791655,
0.026767563,
-0.011548798,
0.0033885797,
0.0062450822,
-0.039128117,
-0.040164985,
0.014611651,
-0.013943144,
-0.00238923,
0.0050172126,
0.023179455,
0.026672062,
0.035253506,
-0.017544895,
-0.015621233,
0.0069920365,
-0.013649819,
0.0017957597,
0.030096455,
-0.0072921827,
0.028377436,
0.00069749827,
-0.040110413,
0.0034926075,
0.0059688115,
0.0041338284,
-0.035744656,
-0.03197919,
0.0054299133,
-0.013179136,
-0.001797465,
-0.016439812,
0.005160464,
0.010443715,
-0.028131861,
-0.00038861227,
-0.0019833508,
0.023370456,
-0.01360207,
-0.0127016315,
-0.0081312265,
0.02079193,
-0.00037496927,
-0.036426805,
-0.017053748,
-0.017776826,
0.030069169,
0.0006506005,
-0.001028341,
-0.010048068,
0.013997716,
-0.0067055337,
-0.0025563568,
-0.0021743528,
0.0009771797,
-0.013793071,
0.027640713,
0.017121963,
0.0013625944,
-0.025307762,
0.018008757,
-0.016630815,
-0.0013233708,
-0.0060984204,
0.009065772,
0.0060813664,
-0.004955819,
0.009154452,
0.017763184,
-0.014939083,
0.009168095,
0.011385082,
0.027272353,
0.008833841,
0.022647377,
0.012858526,
-0.019127483,
-0.013567962,
0.010007139,
-0.03148804,
-0.030614888,
-0.005934704,
0.018527191,
0.016098738,
-0.0028070468,
0.026794849,
0.007558221,
-0.009911638,
0.0027473588,
-0.009481884,
-0.0136225335,
-0.020096136,
0.011501048,
0.006224618,
0.02780443,
0.013520211,
-0.001551891,
0.03197919,
-0.0029093693,
0.014993655,
-0.024311822,
0.01888191,
0.0018349832,
0.037245385,
-0.0054026274,
-0.032224763,
-0.009754743,
0.01843169,
-0.053453267,
-0.0028309221,
-0.00092090236,
-0.0096456,
0.0884612,
0.012135447,
-0.04463989,
0.0076878294,
0.011617013,
0.034735072,
-0.014707152,
0.009297703,
-0.034571357,
-0.0151983,
0.012612952,
-0.00088764756,
0.015307444,
-0.02716321,
-0.028704869,
0.0118080145,
-0.0008718728,
0.004884193,
0.016166953,
-0.015443874,
0.0046283873,
-0.03735453,
0.0008953218,
-0.002479615,
-0.022961166,
0.0020174584,
0.0193867,
-0.015457517,
-0.017012818,
-0.024789328,
0.00018407388,
0.013458817,
-0.019359414,
0.00064249994,
-0.015662162,
-0.023534171,
-0.0065929787,
0.007012501,
0.00955692,
0.0058494355,
-0.011548798,
0.026931278,
-0.029387018,
-0.019959707,
-0.017285679,
-0.02215623,
-0.0054810746,
0.0220198,
-0.009400026
] |
Protein modifications play a major role for most biological processes in living organisms. Amino-terminal acetylation of proteins is a common modification found throughout the tree of life: the N-terminus of a nascent polypeptide chain becomes co-translationally acetylated, often after the removal of the initiating methionine residue. While the enzymes and protein complexes involved in these processes have been extensively studied, only little is known about the biological function of such N-terminal modification events. To identify common principles of N-terminal acetylation, we analyzed the amino-terminal peptides from proteins extracted from Drosophila Kc167 cells. | [
-0.018147444,
-0.0065437392,
-0.00042029296,
-0.027819939,
-0.018568559,
0.018147444,
-0.024411537,
0.02484581,
-0.005277103,
0.00070610864,
0.018686999,
-0.005017196,
0.00070076244,
0.0035729012,
0.010896362,
-0.005066545,
0.038216226,
-0.014594282,
-0.010975321,
-0.0062410627,
-0.03218901,
0.021542687,
-0.0050106156,
-0.01389681,
0.010863462,
0.028241055,
0.027477782,
-0.04532255,
0.013923129,
-0.02585912,
-0.0008710181,
0.011883351,
-0.021634806,
-0.00556333,
0.010870042,
0.000882533,
-0.013699411,
-0.014554802,
0.004813218,
-0.001294601,
0.016673539,
0.015239115,
0.0031155962,
-0.001428667,
0.0046717497,
-0.013284876,
-0.006023925,
-0.000788769,
-0.023542985,
0.024451016,
-0.0032981893,
0.027846258,
-0.028214734,
-0.01663406,
-0.026280235,
-0.0040005967,
-0.023542985,
0.0331102,
0.012672943,
-0.0011333927,
-0.0010749958,
-0.004691489,
-0.024372056,
0.0027421853,
-0.0027685051,
0.0164893,
0.0033886633,
0.0137257315,
-0.017318374,
-0.0019706886,
0.022819193,
0.009659336,
-0.011547775,
-0.00038286962,
0.0165551,
-0.0019739787,
-0.024582613,
0.00045442634,
-0.004349333,
0.026530273,
0.014436364,
-0.004336173,
-0.00016778818,
0.01666038,
0.023490345,
-0.030662468,
0.0051158946,
0.0040170467,
0.002217436,
-0.004543441,
0.023371907,
0.036373846,
0.02408254,
0.015857628,
-0.02587228,
-0.0027997596,
-0.014291605,
0.019081794,
-0.0048526977,
-0.016160306,
-0.03618961,
0.012271567,
0.012350527,
-0.014673241,
-0.016055027,
0.014646921,
0.0059350957,
0.0029708378,
0.007909074,
-0.002033198,
-0.00046923116,
0.031715255,
0.0058495565,
-0.01943711,
0.033057563,
-0.0009450423,
0.033478677,
-0.008540748,
-0.0013480629,
0.012422905,
0.028372653,
0.029451761,
0.04355913,
-0.012186028,
0.014278445,
0.024543134,
0.015265435,
-0.003237325,
-0.010264689,
-0.008198591,
0.015883949,
0.015397034,
-0.018002685,
0.020884695,
-0.026635552,
0.00139001,
-0.011705694,
-0.013028259,
-0.011337217,
-0.029714959,
0.026490793,
0.033662915,
-0.032162692,
-0.00074599945,
-0.0026517112,
0.029135926,
0.022371758,
0.005346192,
0.015515472,
0.017344693,
0.014331085,
0.009323759,
0.024740532,
0.002965903,
-0.018779118,
0.014475843,
-0.015081197,
0.011343798,
-0.030425591,
-0.012765062,
0.0076195574,
0.010666065,
0.006662178,
-0.011008221,
0.031715255,
0.018686999,
0.009179001,
0.0054810806,
-0.0073629403,
0.009527737,
0.012133389,
0.012271567,
-0.011725433,
0.012376846,
-0.021713765,
-0.0006209808,
0.019147594,
0.02485897,
-0.025556443,
-0.01666038,
0.013699411,
-0.0062673823,
0.029636,
0.01838432,
-0.014436364,
0.004888887,
0.021963803,
-0.024766851,
0.022292798,
-0.014528483,
-0.011949151,
0.022963952,
0.0072379215,
-0.016265584,
-0.6409377,
-0.02855689,
0.035610575,
-0.005691638,
0.007902495,
0.041190356,
0.013541494,
0.0027125757,
-0.007514279,
0.02302975,
-0.005829817,
0.017107815,
-0.0066292784,
-0.027635701,
-0.014896959,
-0.025569603,
0.004142065,
-0.016331384,
0.01945027,
-0.0023375198,
-0.03584745,
-0.005655449,
0.0013546428,
-0.00069336,
0.036268566,
0.009106621,
0.01571287,
-0.0052113035,
-0.036215927,
0.022332279,
-0.022542836,
0.009172421,
0.0032998342,
0.022621796,
0.04813876,
0.007909074,
0.002947808,
0.008415729,
-0.010606845,
0.021555847,
0.014554802,
-0.016976217,
0.0059745754,
0.034715705,
-0.010692384,
0.020226702,
-0.008474948,
0.0075998176,
-0.019673986,
-0.011521455,
-0.0030596668,
-0.015923427,
-0.019739786,
-0.0032833845,
-0.009402718,
0.020753095,
0.01951607,
-0.006948405,
0.030030794,
0.0087907845,
0.005981155,
0.010297589,
-0.0073366207,
-0.03045191,
-0.018226402,
0.010712124,
-0.009744874,
0.020121422,
-0.011271418,
0.010606845,
0.009165841,
0.04066396,
0.012264987,
-0.011850452,
-0.0078103757,
0.024595775,
0.011370117,
0.009738294,
-0.011889932,
0.014173167,
0.004520411,
0.0026155217,
-0.005889036,
-0.024608934,
0.016791979,
0.020542538,
0.0060107647,
0.031662617,
0.021016292,
-0.008251231,
0.0010453862,
-0.0056258393,
-0.025122168,
-0.024622094,
-0.024358897,
0.029951835,
-0.0075998176,
-0.0110806,
0.021476887,
-0.0018029005,
-0.01851592,
0.018318523,
0.0015413483,
-0.0023292948,
0.020253021,
-0.026109157,
-0.000922835,
0.018871237,
0.0707474,
0.018660678,
0.004359203,
-0.014660082,
-0.013962609,
-0.018937035,
-0.005375802,
-0.011422756,
-0.0036288307,
-0.0008677281,
-0.008382829,
-0.043243293,
-0.012232088,
0.014094207,
0.013738891,
0.0006287944,
0.024200978,
0.018121123,
-0.010159411,
-0.020121422,
-0.004306563,
0.0050204857,
0.008159112,
-0.0012468965,
0.01939763,
-0.014607442,
0.015844468,
0.016226104,
0.029399121,
0.0240957,
0.008678926,
-0.03492626,
-0.010843723,
-0.0056751887,
-0.0030415722,
-0.0010264689,
-0.023595626,
-0.02947808,
-0.02871481,
0.007514279,
0.014528483,
0.023358747,
0.013738891,
0.027161947,
-0.008264391,
0.011139819,
-0.000008861057,
-0.002497083,
-0.02787258,
-0.019252872,
-0.0045171212,
0.0013357255,
-0.0017996106,
0.0075340187,
-0.026122317,
0.012238667,
-0.012784801,
-0.028030496,
0.014923278,
0.004744129,
-0.017292053,
-0.03429459,
0.016791979,
-0.021042611,
-0.021647966,
-0.0064911,
-0.016239265,
0.014581122,
-0.0072576613,
0.010337068,
0.0071392227,
0.005908776,
-0.007290561,
-0.02493793,
-0.0054843705,
-0.0060699843,
0.029004326,
0.0065437392,
0.036452804,
-0.004362493,
-0.00554359,
0.03329444,
0.0120215295,
-0.00042934035,
-0.026503954,
-0.0019229841,
0.009935693,
-0.03405771,
0.026503954,
-0.005724538,
-0.00925138,
0.017423652,
0.030715108,
0.005438311,
0.0009063852,
-0.027398823,
-0.014094207,
-0.006563479,
-0.00037032663,
-0.015568112,
0.00083565095,
0.002497083,
-0.023569304,
-0.00323897,
-0.0011835647,
-0.008771045,
-0.0047309687,
0.0012288017,
-0.00091872254,
-0.01939763,
-0.01290982,
-0.00054202165,
0.037479274,
-0.039611172,
0.023450866,
-0.009988332,
-0.009455358,
0.022227,
0.018871237,
0.019805586,
-0.017397331,
-0.012482125,
0.0072839814,
0.00044825766,
0.0041091656,
0.009810674,
0.024780013,
0.032031093,
0.006372661,
-0.017792128,
0.046664856,
-0.0033853734,
0.007007624,
0.002944518,
0.0043921024,
-0.028241055,
0.010014651,
0.011580675,
0.040137567,
0.017410493,
-0.011508295,
-0.000743532,
0.0027520552,
0.02026618,
-0.0054876604,
-0.0059647053,
0.003053087,
-0.0014089273,
0.031662617,
0.018173764,
0.053692218,
0.026635552,
-0.015318074,
-0.006218033,
-0.013475694,
-0.0012353816,
0.003153431,
-0.0038328085,
0.013475694,
-0.017384171,
-0.01854224,
-0.020081943,
-0.026280235,
-0.012890081,
0.011350377,
0.0042111543,
0.009317179,
0.011152979,
0.013429634,
0.009909373,
0.0052047237,
0.006313442,
-0.027030347,
-0.008646026,
0.035347376,
0.030293992,
-0.0017732908,
-0.016502462,
-0.013923129,
-0.004691489,
-0.013567814,
0.006566769,
-0.0105871055,
0.00834335,
-0.006803646,
0.0044414517,
-0.028451612,
-0.019266032,
0.0018654098,
-0.03603169,
0.020582017,
-0.02960968,
0.009771194,
0.0003664198,
-0.021055773,
0.020976814,
0.03247853,
0.015410193,
-0.0030070276,
-0.014186326,
-0.008132792,
-0.026977709,
0.014857479,
-0.014120528,
0.021819044,
-0.03053087,
0.024372056,
0.0046585896,
0.0044414517,
0.011508295,
0.020542538,
0.01105428,
-0.020016143,
-0.0029001036,
-0.014712721,
0.012738742,
0.040979795,
0.020002984,
0.00061604584,
0.0331102,
-0.0020891274,
0.018752797,
-0.03447883,
-0.0005905486,
0.026464473,
-0.004964556,
-0.025740681,
-0.006402271,
-0.001066771,
0.00045195885,
0.016041866,
0.005346192,
-0.016278744,
-0.017936885,
0.004990876,
-0.003513682,
0.029188564,
-0.017831607,
0.03874262,
0.014712721,
0.015370714,
-0.004359203,
0.0074155796,
0.016081346,
0.010731864,
-0.023793023,
0.015410193,
-0.014344245,
-0.008007773,
-0.00009407242,
-0.009113201,
0.009382978,
0.011205619,
0.009494837,
0.022332279,
-0.0030958564,
0.009211901,
0.021516368,
0.019871386,
0.019976664,
-0.021476887,
-0.012844021,
0.0060436646,
0.0059647053,
-0.014857479,
-0.010626585,
-0.00053955417,
-0.024727372,
-0.009962012,
-0.028083136,
0.012245247,
-0.010764764,
0.018792277,
-0.012442646,
-0.009067141,
-0.010067291,
-0.0060337945,
-0.025556443,
0.007211602,
-0.0044908016,
-0.009639596,
-0.0184896,
0.003046507,
-0.01843696,
-0.009744874,
-0.020753095,
0.01859488,
-0.037321355,
-0.0055534597,
-0.029767597,
0.016239265,
0.03053087,
-0.0018802147,
-0.03695288,
-0.005359352,
0.027846258,
-0.023187669,
-0.006727977,
-0.021055773,
-0.032847006,
-0.00064606674,
-0.007409,
0.01748945,
-0.03155734,
-0.0077182567,
-0.010600265,
-0.0049678464,
-0.011330637,
0.0004268729,
0.0009491547,
-0.02863585,
0.012541344,
0.011982051,
0.023345588,
0.012061009,
-0.016791979,
-0.0072510815,
0.004898757,
0.0049546864,
-0.037610874,
-0.00648123,
-0.032452207,
-0.0028030497,
0.008461788,
-0.010988481,
-0.0067213974,
0.009073722,
-0.002493793,
-0.0020216831,
0.031188862,
0.020976814,
0.03221533,
-0.0060305046,
0.034268267,
-0.004056526,
0.0016795269,
-0.00018855608,
-0.018818596,
0.04329593,
0.01010677,
-0.011291157,
0.015620751,
0.01677882,
-0.001294601,
-0.016068187,
0.0014714366,
-0.029320164,
0.014870639,
-0.015857628,
-0.040111247,
-0.029372802,
-0.022977112,
-0.013515173,
-0.0103436485,
-0.010514726,
-0.0067115272,
-0.0027569903,
0.005622549,
-0.012719003,
0.009836993,
-0.0073629403,
-0.036347527,
-0.00930402,
0.0031797506,
-0.0019904284,
0.008428888,
0.0043032733,
-0.016515622,
-0.019555548,
-0.005856137,
-0.021226851,
-0.036584403,
-0.0018604748,
-0.016436663,
0.034715705,
0.02871481,
0.024529975,
-0.021990122,
0.011218779,
0.01566023,
0.0067181075,
0.019555548,
-0.017805288,
0.010481827,
-0.022424398,
0.013041419,
0.029241204,
-0.025345886,
0.010731864,
-0.0060272147,
0.012547924,
0.016528782,
-0.008507848,
-0.045664705,
0.014949598,
-0.040585,
-0.023306107,
0.0120215295,
-0.011001641,
0.008632867,
-0.02581964,
-0.013988929,
0.0006904813,
0.010955581,
0.009165841,
-0.016528782,
0.03263645,
-0.011363537,
0.014410044,
0.010718704,
0.009382978,
0.02127949,
-0.029135926,
-0.0016244199,
0.006185133,
0.035505295,
-0.0085473275,
0.0166209,
-0.009376398,
-0.016449822,
-0.008757886,
0.0015668456,
-0.025674881,
0.0054843705,
-0.0126597835,
-0.011356957,
-0.010310749,
-0.0033409589,
0.009040822,
-0.05711378,
0.009165841,
0.006382531,
0.00032611773,
-0.0034840724,
-0.014423204,
-0.0020677426,
0.06185133,
-0.012870341,
0.008205172,
-0.02674083,
0.0016046801,
0.021463728,
0.010481827,
-0.018423801,
-0.032110054,
-0.004359203,
0.024398375,
0.023885142,
0.008652606,
-0.001482129,
-0.018686999,
-0.019344991,
0.000070271584,
-0.015989227,
-0.044006564,
-0.01113324,
-0.016068187,
0.015199635,
-0.011508295,
0.006287122,
-0.0022914603,
0.01577867,
-0.0025168227,
-0.0063595013,
-0.0011827422,
-0.027319865,
-0.015962908,
0.023556145,
0.019871386,
0.040084925,
0.01748945,
0.006076564,
0.016397182,
-0.011409597,
-0.004507251,
-0.00092119,
0.01666038,
0.01748945,
0.0065930886,
-0.00027594576,
0.019042313,
-0.0019690436,
0.00827755,
0.0023753543,
-0.012593984,
0.03971645,
-0.012646623,
-0.010409447,
-0.0030613118,
0.011560935,
0.0040433663,
0.008988183,
0.008764465,
-0.025122168,
-0.022213839,
-0.002044713,
0.0134230545,
0.035584256,
-0.019792426,
-0.011291157,
-0.0115017155,
0.013804691,
-0.026503954,
-0.01379153,
0.000051868345,
-0.023871982,
-0.015081197,
-0.0019986534,
0.0104357675,
0.010889783,
-0.0050270655,
0.010968741,
-0.020042462,
0.035163138,
-0.015568112,
-0.014173167,
-0.0020035882,
-0.026530273,
0.009665916,
0.0037999088,
-0.031004624,
0.012620304,
0.026451314,
-0.022069082,
-0.031057265,
0.015212796,
0.004444742,
0.04087452,
0.015581272,
-0.029267523,
0.002227306,
-0.00736952,
0.010685804,
-0.012343947,
-0.03160998,
0.0071787024,
-0.034768343,
0.016910417,
0.00278331,
-0.009080302,
-0.01937131,
0.014265286,
-0.060430065,
-0.00028088072,
-0.018292202,
-0.012297887,
-0.020318821,
0.008685506,
-0.008409149,
0.0022421107,
0.008711826,
-0.022542836,
-0.020753095,
-0.00078835775,
-0.015502312,
0.022003282,
-0.033189163,
0.009817254,
-0.0008142662,
0.00020778182,
-0.0076524573,
-0.008665767,
-0.0011218778,
-0.032768045,
-0.02868849,
0.007461639,
-0.032136373,
0.024319418,
0.031215182,
-0.026977709,
-0.004523701,
-0.00831045,
-0.05013906,
0.0027471203,
-0.013376995,
-0.0012534765,
0.015883949,
0.015397034,
-0.0017963205,
0.005254073,
-0.0043164333,
0.0024691182,
-0.020450419,
-0.012850601,
0.014660082,
0.012482125,
0.021305809,
0.017423652,
-0.041822027,
-0.0166867,
0.028188415,
-0.028872728,
-0.016133985,
0.0058824564,
-0.009652755,
0.020674136,
-0.024174659,
0.013765211,
0.011416176,
0.029399121,
0.0034084031,
-0.02393778,
-0.014423204,
0.015515472,
-0.000324884,
-0.054008055,
0.019700307,
-0.0040104664,
0.004339463,
0.011646474,
0.008540748,
-0.013363835,
0.0077972156,
-0.014054728,
0.029372802,
0.029214883,
-0.007112903,
-0.010705545,
0.009711975,
-0.0040005967,
-0.023332428,
0.000010827324,
-0.017831607,
-0.015318074,
-0.00556333,
0.0055929394,
-0.0011564225,
-0.001746971,
0.01943711,
-0.019805586,
-0.003227455,
-0.0046816193,
0.003510392,
-0.016384022,
-0.010409447,
0.015818149,
-0.020200381,
0.01755525,
0.012133389,
-0.008093312,
0.020200381,
-0.014831159,
-0.016094506,
0.0058725863,
0.008955283,
0.007816955,
-0.007770896,
-0.0014196197,
0.0072445017,
-0.020792576,
-0.032689087,
0.008797365,
0.17392068,
-0.02505637,
-0.0055172704,
0.0059416755,
0.005306713,
-0.0065174196,
-0.01579183,
-0.015976068,
-0.008586807,
-0.0053132926,
0.030715108,
0.010902942,
-0.019266032,
-0.008771045,
0.014581122,
-0.019055475,
-0.018884396,
0.017265733,
-0.029293843,
0.020529378,
-0.0040960056,
0.0021549268,
0.004704649,
0.013699411,
0.04266426,
-0.0044250023,
-0.012745322,
-0.0032784496,
0.0059186458,
0.006165393,
0.0010388063,
-0.0035367117,
0.0065207095,
-0.014633762,
0.00007412701,
0.01295588,
0.011718853,
0.005260653,
0.005086285,
-0.016344544,
0.017673688,
0.020779416,
-0.0073497803,
-0.02947808,
-0.005714668,
0.023411388,
0.0020710325,
-0.020950492,
-0.024516815,
0.004816508,
-0.05737698,
0.0009812319,
0.008073573,
0.016923577,
0.022924472,
0.0012362042,
-0.026372354,
0.0037735892,
0.008270971,
0.03597905,
-0.03326812,
0.0062640924,
-0.0332418,
0.0155549515,
-0.01293614,
0.0017124264,
-0.00075340184,
0.0022519806,
0.031531017,
-0.02766202,
0.016265584,
0.0016861068,
-0.008573648,
-0.0019838486,
-0.006662178,
-0.008442049,
0.035663214,
0.043032736,
0.007211602,
0.018621199,
-0.0052836826,
0.02033198,
-0.019476589,
-0.026596073,
-0.013580973,
-0.023385067,
0.0220954,
-0.0041815448,
-0.019555548,
-0.0018160604,
0.008507848,
-0.009402718,
-0.015331234,
0.002952743,
0.016173465,
0.0004379765,
0.008297291,
-0.004559891,
0.0064253006,
-0.01020547,
-0.029662319,
0.05648211,
0.002755345,
0.0064154305,
-0.0072576613,
-0.013284876,
-0.031109903,
0.015607591,
-0.009836993,
-0.018871237,
0.004523701,
-0.019976664,
0.0019361441,
-0.01484432,
-0.016199784,
0.018107964,
0.00930402,
-0.022700755,
0.048454598,
-0.0111990385,
0.006402271,
-0.011488556,
-0.009448778,
0.013126958,
0.009060562,
0.0056784786,
-0.006672048,
-0.010383127,
-0.01480484,
-0.027346184,
-0.002024973,
0.012817701,
-0.0049382364,
0.0012584113,
-0.014594282,
-0.0043855226,
-0.0071589625,
-0.01935815,
-0.0014434719,
0.033452358,
-0.012896661,
-0.00019451915,
-0.008803945,
-0.0027685051,
-0.0008998053,
-0.0065239994,
-0.011416176,
0.019568708,
-0.012330786,
0.0014607442,
0.0015800054,
-0.01941079,
-0.0053198724,
-0.0014155072,
-0.011567514,
-0.008764465,
-0.012561084,
-0.03416299,
-0.020660976,
-0.002960968,
-0.033794515,
-0.01013967,
0.037347674,
-0.01755525,
0.005201434,
0.013186177,
-0.16423503,
0.0071589625,
0.00063331815,
-0.021726925,
0.023450866,
0.0024378637,
0.023687745,
-0.019266032,
-0.00827755,
-0.0052310433,
0.026911909,
-0.019884545,
-0.045927905,
-0.039347973,
0.011416176,
0.02134529,
-0.008165692,
0.026148638,
-0.0092448,
0.0011613574,
0.005181694,
-0.017094655,
0.024582613,
-0.012297887,
0.008198591,
0.040585,
0.010633165,
-0.016120825,
-0.02399042,
-0.013344096,
0.01106086,
0.0067773266,
0.022345439,
0.004155225,
0.029504402,
0.015225955,
-0.0033606987,
0.0030251222,
0.0033672785,
0.023740383,
0.0102844285,
0.026043357,
-0.010560785,
-0.0083630895,
-0.0012765062,
0.015015397,
0.025293246,
0.008830264,
0.039137416,
0.008646026,
0.0027849548,
0.01014625,
0.00831045,
0.028899048,
0.025951238,
0.008205172,
-0.011600414,
0.0048757275,
-0.009751455,
-0.030136075,
0.019173913,
0.012817701,
0.030636149,
0.005997605,
-0.006385821,
-0.021582166,
-0.0166209,
0.016107665,
-0.045980543,
-0.008593387,
0.014870639,
-0.0038459683,
-0.0029790627,
-0.020674136,
0.008922383,
0.010758184,
-0.010922682,
0.00096642703,
0.011139819,
-0.0077248365,
-0.012107069,
0.016120825,
-0.021437408,
-0.026977709,
-0.019344991,
-0.0077445763,
0.012304467,
0.017726328,
-0.026122317,
-0.019213391,
0.025030049,
-0.02674083,
-0.0009433973,
-0.007941974,
0.026069678,
0.027609382,
0.0054284413,
0.0066128285,
-0.016318224,
0.014067888,
0.0110148005,
-0.0039315075,
-0.013409895,
0.027214585,
0.009738294,
0.026556592,
-0.0022125011,
-0.00277015,
0.019344991,
0.0133901555,
-0.016989376,
0.023819342,
-0.001850605,
0.030899346,
-0.024345737,
0.024161499,
0.0038196486,
-0.011541195,
-0.014186326,
0.0064582,
0.06516761,
0.015923427,
0.0072839814,
0.010416027,
-0.0030119624,
-0.018805437,
-0.13559917,
-0.016173465,
-0.0072445017,
0.024319418,
0.0040203365,
0.012304467,
0.001941079,
0.026030198,
-0.018673837,
0.03982173,
-0.015015397,
0.0040927157,
0.011475395,
-0.022292798,
-0.007310301,
0.026451314,
0.013988929,
-0.0061423634,
-0.015357554,
0.03811095,
0.007119483,
0.0038393885,
-0.002962613,
-0.011389857,
0.013344096,
0.0010947357,
-0.022753393,
0.023306107,
0.0016745919,
-0.003130401,
0.0051520844,
-0.028978007,
0.020674136,
0.00833019,
-0.0053922515,
0.012422905,
0.008106472,
-0.013179597,
0.025398524,
-0.01201495,
-0.017094655,
-0.016212944,
0.016186625,
-0.022292798,
0.027819939,
-0.0085473275,
-0.0057705976,
0.0069813044,
-0.014225806,
0.0010610136,
-0.015120677,
0.002414834,
-0.031188862,
-0.01290982,
0.042111546,
0.0010988481,
0.0037637192,
0.036663365,
-0.023332428,
-0.008724986,
0.00033886635,
0.004454612,
-0.01759473,
-0.0010881558,
0.034899943,
-0.016028706,
-0.028267374,
-0.02395094,
0.027082987,
-0.03247853,
0.011146399,
0.005925226,
-0.0026204567,
-0.018055325,
-0.032452207,
0.0024411536,
-0.026267076,
-0.011238518,
0.012199188,
-0.020766255,
-0.016976217,
-0.02676715,
0.0024707632,
-0.021911163,
-0.014094207,
0.018239563,
0.026372354,
-0.0048592775,
0.006744427,
-0.016384022,
0.0026681612,
0.023898302,
0.006783907,
0.0037505594,
-0.022727074,
0.010238369,
-0.0027125757,
-0.027267225,
0.02324031,
0.03221533,
-0.024608934,
-0.014949598,
-0.03616329,
-0.0025661723,
-0.0015512182,
-0.0043986826,
0.025227448,
0.010725284,
0.018265883,
0.0039512473,
-0.0044019725,
0.007698517,
-0.023345588,
-0.0133901555,
-0.012311047,
-0.031767897,
-0.01477852,
0.002873784,
0.060640626,
0.0032850294,
0.02408254,
0.02322715,
-0.009810674,
-0.015252275,
0.015344394,
0.02505637,
-0.0013036483,
-0.008501268,
-0.012284727,
-0.008218331,
0.00041391863,
-0.0044052624,
-0.0044052624,
-0.027819939,
0.0029264234,
0.0066128285,
-0.02758306,
-0.02414834,
-0.031109903,
0.021832203,
0.013607292,
0.022082241,
-0.03145206,
-0.025595924,
-0.001746971,
-0.0060535343,
0.0011712273,
-0.016239265,
-0.029636,
0.001659787,
0.003516972,
-0.04437504,
0.034110352,
0.025424846,
-0.0042012846,
-0.017765807,
-0.0005321517,
-0.010455507,
0.002401674,
-0.010356808,
-0.015765509,
-0.02043726,
0.02304291,
-0.002233886,
0.01760789,
0.00017035847,
-0.0050632553,
0.011580675,
-0.033662915,
0.0048494074,
0.010876622,
-0.011600414,
-0.0062081628,
0.008810525,
0.019121272,
0.0033129943,
0.030136075,
0.006221323,
-0.011370117,
0.014357405,
-0.0107713435,
0.013633613,
0.03332076,
-0.0132388165,
-0.024701053,
0.030083435,
0.040979795,
-0.027925218,
-0.0024230587,
0.004510541,
-0.008902644,
0.0023687743,
0.014252126,
0.026688192,
-0.009514577,
0.0058462666,
-0.0025530125,
0.015015397,
-0.018805437,
-0.00838941,
0.013370415,
0.019226551,
0.010488407,
-0.005365932,
-0.003990727,
-0.026543433,
-0.016976217,
0.026003879,
-0.035321057,
-0.060640626,
0.0063331816,
-0.010442347,
0.01393629,
-0.0060469545,
0.011291157,
0.015370714,
-0.0031962004,
0.010698964,
0.0017667109,
-0.005803497,
-0.00925138,
-0.008099892,
0.0056817685,
-0.002678031,
0.02324031,
-0.014054728,
0.006283832,
0.0067970664,
0.010198889,
-0.025451165,
0.008711826,
-0.0011235229,
-0.0063233115,
-0.03045191,
-0.021805884,
-0.0022700755,
-0.011330637,
-0.0041354853,
0.020529378,
0.0054810806,
0.0064187204,
0.06785223,
0.016884098,
0.0033755035,
0.009527737,
-0.007856435,
0.032610126,
0.01768685,
0.027004028,
-0.012304467,
0.00069664995,
-0.0057607275,
-0.0049546864,
0.020963654,
-0.03963749,
-0.0203583,
0.020608338,
-0.009455358,
0.012186028,
-0.020134581,
-0.017371012,
0.014002088,
-0.019673986,
0.002673096,
0.0025859121,
-0.017910566,
0.0133309355,
0.02225332,
-0.012212348,
0.015028558,
-0.013923129,
0.015936587,
0.014989078,
-0.051086567,
-0.0042111543,
-0.0115938345,
-0.005655449,
-0.018634358,
-0.008257811,
0.00929744,
0.011435917,
0.007211602,
-0.017081495,
-0.0132980365,
-0.007211602,
-0.013100638,
-0.009633016,
-0.00047951232,
-0.004803348,
-0.011870191
] |
BACKGROUND AND AIMS Previous in vitro and in vivo studies have revealed an association between Helicobacter pylori infection and apoptosis in gastric epithelial cells. Although involvement of the Bcl-2 family of proteins as well as cytochrome c release has been demonstrated in H pylori induced cell death, the exact role of the mitochondria during this type of programmed cell death has not been fully elucidated. Therefore, we sought to determine whether or not Bax translocation and mitochondrial fragmentation occur on exposure of gastric epithelial cells to H pylori, resulting in cell death. METHODS Experiments were performed with human gastric adenocarcin | [
-0.0062481263,
-0.01697302,
-0.0006283987,
-0.027647875,
-0.028688673,
0.026006617,
-0.009207062,
0.018334065,
-0.0061146906,
-0.0012459557,
0.0013009979,
0.009727462,
0.00091486843,
0.020028697,
-0.010628153,
0.0061780727,
0.029702784,
-0.0024068463,
0.0016003943,
0.028982231,
-0.030877018,
0.01809388,
-0.001889783,
-0.014064122,
0.016892958,
0.015678693,
0.004460088,
-0.034266286,
-0.009487278,
-0.011982525,
-0.0018597599,
0.015118264,
-0.01398406,
0.007799316,
0.002752111,
-0.029329164,
0.014424398,
-0.005634322,
0.013477005,
0.013283523,
0.010821634,
0.0044500805,
-0.0061347056,
0.014464429,
-0.004736967,
0.010574779,
0.0077459416,
-0.021669956,
-0.0017313281,
-0.0066784564,
0.021002777,
-0.0028121572,
-0.0027787983,
0.0035760766,
0.006931984,
-0.013276851,
0.0015436842,
0.0086266175,
-0.0023317887,
-0.021403085,
0.0063915695,
0.0016679461,
-0.025579622,
0.007565804,
0.0020799288,
0.020429004,
-0.012549627,
-0.01622578,
0.016359216,
0.0047236234,
0.06031293,
0.04123163,
-0.0044167214,
0.008239654,
0.02882211,
-0.006721823,
-0.025819806,
-0.00953398,
-0.008920176,
0.016692804,
0.019348174,
-0.025379468,
0.017586824,
0.029969655,
0.009727462,
-0.008446479,
-0.033865977,
0.0062814853,
0.007225543,
0.0008460657,
0.0150115155,
0.026073333,
0.030369963,
0.026086677,
-0.005794445,
0.035787452,
-0.006571708,
0.03666813,
-0.0036294507,
-0.015785443,
-0.006828571,
-0.015998939,
-0.01850753,
-0.0071988553,
-0.030663522,
0.017800322,
0.008059516,
-0.022403853,
0.01944158,
-0.0050638844,
-0.017239891,
0.040617824,
-0.0111618955,
-0.033545732,
0.0009782504,
-0.011041803,
0.015865503,
0.007058748,
-0.026647108,
-0.008606602,
-0.00377623,
0.014838048,
0.019641733,
-0.033038676,
0.019748483,
-0.013690501,
-0.018827775,
-0.007212199,
0.014437742,
-0.00019973655,
-0.008239654,
0.0323715,
0.0061413776,
0.0076391934,
-0.008459822,
0.021563208,
-0.021669956,
-0.024885757,
-0.021643268,
-0.027074102,
0.0073189475,
0.027674561,
0.0040397653,
-0.011942495,
-0.005190648,
0.002937253,
0.022203699,
0.028315054,
-0.008373089,
0.029889595,
0.0055976273,
-0.034826715,
0.010187815,
-0.027914746,
0.005420825,
0.012856529,
-0.006741838,
0.017640198,
-0.025566278,
-0.04205893,
-0.00886013,
-0.012382832,
0.008219639,
-0.00016085255,
0.017319953,
0.03682825,
0.00904694,
0.019561673,
-0.0027004047,
-0.024725633,
-0.008966878,
0.0014110825,
-0.025552934,
0.00089818897,
0.008760053,
0.01263636,
-0.0017038069,
0.026553702,
0.00736565,
-0.018147254,
-0.0340261,
0.015985595,
0.024939131,
-0.0060279574,
-0.00687861,
-0.0031207271,
0.025899867,
0.0019398213,
0.007705911,
-0.03375923,
0.004883746,
0.023084374,
-0.0067852046,
0.00600127,
-0.6268275,
-0.02796812,
-0.0036060994,
-0.0019981994,
0.009707446,
0.014944797,
0.011041803,
0.0005429165,
-0.019948635,
0.0016979692,
-0.014571177,
0.023911675,
0.0179471,
-0.024165204,
-0.005324084,
-0.024031768,
-0.0012668051,
-0.019174708,
0.022750786,
-0.0067618536,
-0.011949166,
-0.015184982,
-0.005414153,
0.028475177,
-0.013477005,
0.043953717,
0.018947868,
-0.0130967125,
-0.0003060681,
0.04269942,
-0.018240659,
0.026220113,
-0.00878674,
-0.017093113,
0.04325985,
-0.010748245,
0.009320483,
0.0059078652,
0.0010141112,
0.030663522,
-0.0009357178,
-0.010674855,
0.010574779,
0.018987898,
-0.0044200574,
0.004706944,
0.014757987,
0.014944797,
0.0068519227,
0.018013818,
-0.000355898,
0.013703845,
-0.029702784,
0.012082602,
0.011415423,
0.01032125,
0.01966842,
-0.0350669,
0.0063982415,
0.007112122,
0.015265043,
0.01869434,
-0.011295331,
-0.022110295,
-0.010254533,
-0.0047236234,
-0.027541127,
0.010434671,
0.0014069126,
-0.0005537581,
0.023831613,
0.0049504642,
-0.01861428,
-0.0030256542,
0.021803392,
0.052920595,
-0.017279921,
0.029862907,
-0.0059579033,
0.011408752,
0.014891423,
-0.0064816386,
-0.02635355,
0.014224244,
0.027327629,
-0.007939423,
-0.023671491,
0.018934524,
-0.006321516,
-0.0017296601,
0.013063354,
-0.0024185218,
-0.01144211,
-0.024472106,
-0.01790707,
0.032051254,
-0.03114389,
-0.0050405334,
0.0007580815,
-0.02344465,
-0.006221439,
-0.0050872355,
0.012135976,
0.027834686,
0.010854993,
-0.0014386035,
-0.037041746,
-0.014651239,
0.03466659,
-0.01282317,
0.004183209,
-0.0038529555,
0.0070187175,
-0.009940959,
0.00090235885,
-0.03039665,
0.051132556,
0.010961742,
-0.003686161,
-0.038723037,
0.020695876,
-0.02740769,
-0.0025286062,
-0.008573243,
0.010628153,
0.0111618955,
0.018987898,
-0.037895735,
0.0044467445,
0.0017613511,
0.007399009,
-0.0058378116,
0.019348174,
-0.0010916707,
0.012969949,
0.011261973,
0.028368428,
-0.012482909,
-0.0010599798,
-0.025259376,
-0.036774877,
-0.006998702,
0.013797251,
0.01196251,
-0.019775169,
-0.004887082,
-0.023898331,
-0.0052039917,
0.010427999,
0.01020783,
0.026607076,
0.016279154,
0.0033625793,
0.005167297,
0.030636834,
-0.006781869,
-0.014077465,
-0.022337135,
-0.004259934,
-0.018574247,
0.017333295,
0.036508005,
-0.011542187,
-0.0025736408,
-0.0075191013,
0.0179471,
0.02195017,
-0.0012909903,
0.023831613,
-0.03552058,
0.008373089,
-0.010774932,
-0.014437742,
0.0036461302,
-0.009133673,
-0.0059345523,
-0.022550631,
-0.0038763068,
-0.011535515,
0.0015970584,
0.03738868,
-0.03525371,
0.013690501,
-0.0029539326,
0.017093113,
0.038856473,
0.01009441,
0.020855999,
0.003284186,
0.031677634,
-0.009507293,
0.012182678,
-0.0112019265,
0.017706916,
-0.0009165364,
-0.0019681763,
-0.006324852,
0.013510363,
-0.0038029172,
0.031357385,
0.0111952545,
-0.02348468,
0.0137305325,
-0.020775937,
0.037522115,
0.014704613,
-0.009754149,
0.00011039718,
0.02176336,
0.002817161,
-0.0015720392,
-0.011835746,
-0.028795421,
-0.02807487,
0.00204657,
-0.010374625,
0.009453919,
0.0036961685,
-0.0036628097,
-0.030850332,
-0.004406714,
0.0049704793,
-0.00027062427,
0.013130072,
-0.015411822,
0.00807286,
-0.0075991624,
0.024365356,
-0.019094648,
-0.018787745,
0.017146487,
0.025512904,
0.0019464932,
-0.005847819,
0.038402792,
0.02475232,
0.014624552,
0.0096474,
0.040431015,
0.010187815,
-0.017840352,
0.017746946,
-0.023151092,
0.010794947,
-0.010828306,
0.0037929094,
0.014250931,
-0.0058044526,
-0.014250931,
0.019334832,
-0.007058748,
0.006071324,
-0.030610148,
-0.0019931956,
0.0029439249,
-0.03077027,
-0.011782371,
0.004603531,
0.034266286,
0.011829074,
0.02479235,
-0.016799554,
0.004740303,
-0.021843422,
0.008653305,
0.01749342,
0.006034629,
0.010294563,
-0.01772026,
-0.0009382197,
-0.019388206,
-0.017733604,
0.010361281,
-0.03773561,
0.02037563,
0.015611975,
0.008252997,
0.030183153,
-0.004493447,
0.011829074,
-0.025806462,
-0.03525371,
0.026206769,
0.013643799,
-0.014144183,
-0.013917343,
-0.03271843,
-0.0013793914,
-0.019468267,
0.024445418,
0.00027792153,
0.009587354,
0.003344232,
0.012269411,
-0.0047803335,
-0.024071798,
0.0077526136,
-0.026500328,
0.030796956,
0.018160596,
-0.01603897,
0.0064749666,
-0.02796812,
-0.00035527252,
0.03645463,
0.016932989,
-0.00818628,
-0.022190355,
-0.0039797192,
-0.022790816,
-0.0065450207,
0.013537051,
-0.010928383,
0.008566571,
-0.018187284,
0.011989197,
-0.016879614,
0.016252467,
0.02377824,
0.009667416,
-0.018934524,
-0.024205234,
-0.010201159,
-0.004600195,
0.01230277,
0.03263837,
-0.0017213204,
0.017973788,
0.021509834,
0.032611683,
0.024085142,
-0.03690831,
0.013290195,
-0.009874241,
0.012329457,
0.0044367365,
-0.0019831879,
0.0012459557,
0.026527015,
0.007772629,
0.0059879264,
-0.030877018,
-0.004176537,
-0.0027404355,
-0.011909136,
-0.0068452507,
0.029542662,
0.01902793,
0.007932751,
-0.01375722,
0.0049571358,
0.025032535,
0.009440575,
-0.0073256195,
0.005694368,
0.01836075,
0.018547561,
0.009500621,
-0.022710754,
-0.020909373,
0.008453151,
0.009747477,
0.013783907,
0.011995869,
0.00488041,
-0.0034926792,
-0.001858092,
-0.0039430247,
0.0040130783,
0.00015772515,
-0.0015011515,
0.012489581,
-0.013190118,
-0.010801619,
0.028742047,
-0.005754414,
0.001332689,
-0.040244203,
0.017893726,
-0.00564433,
-0.012969949,
0.009674087,
0.0011884116,
0.005530909,
-0.011655607,
-0.029702784,
0.01992195,
-0.0005712715,
0.014197557,
-0.0023951707,
-0.03450647,
-0.03664144,
-0.043580096,
0.0012659711,
0.012643032,
-0.038829785,
-0.026473641,
0.018814432,
0.00807286,
0.02130968,
0.02176336,
-0.040911384,
-0.008346402,
0.034186225,
-0.0033942703,
-0.0028071534,
-0.014157527,
-0.051159244,
0.0033358922,
-0.010254533,
0.0007088771,
-0.026019959,
-0.01992195,
0.014704613,
0.0036427942,
-0.0077459416,
-0.007459055,
-0.0057177194,
-0.014557834,
0.011502156,
0.0069186403,
0.016385904,
-0.011095177,
0.004706944,
0.009620713,
-0.03618776,
-0.02639358,
-0.027781311,
0.014064122,
-0.026713826,
-0.010367953,
0.0076391934,
0.009100314,
-0.005107251,
0.009147016,
-0.0039363527,
0.009680759,
0.0013026659,
0.0313307,
0.043233164,
-0.02751444,
0.031757694,
0.009867569,
-0.00034922623,
-0.010054379,
0.00266371,
0.03541383,
0.004463424,
0.008393105,
0.0003342147,
-0.0067885406,
-0.033011988,
-0.027621187,
-0.026673794,
-0.01880109,
0.024258608,
0.004089804,
-0.030823644,
-0.021896796,
0.01293659,
-0.011722325,
0.021963514,
-0.0131100565,
-0.04552826,
-0.008192952,
0.00042616023,
-0.0003310873,
0.0024568846,
0.010754917,
-0.039950646,
-0.0067852046,
0.0076391934,
0.0062447903,
-0.014744644,
0.00755246,
-0.010227846,
-0.037442055,
0.010174471,
-0.012883216,
-0.019575017,
-0.004820364,
-0.019468267,
0.022270417,
0.027621187,
0.031304013,
-0.00018034667,
0.027314285,
0.020802625,
0.010988429,
0.012836513,
-0.02531275,
0.0070387325,
-0.015585288,
0.027487753,
-0.011135208,
-0.016345872,
0.0012968282,
-0.0165994,
0.008886817,
0.0007255566,
-0.0075124293,
-0.0016529346,
-0.011875777,
-0.028742047,
-0.038482852,
0.01832072,
-0.032931928,
-0.017039737,
-0.037095122,
-0.0030706888,
0.013823938,
-0.0051472816,
-0.007459055,
0.008166264,
-0.0073189475,
-0.011895792,
0.024045112,
-0.0033242167,
-0.0034893432,
0.00717884,
-0.010794947,
0.009827538,
-0.004053109,
-0.0063615465,
0.018067192,
0.0074056806,
-0.004656906,
-0.03394604,
0.0017563473,
0.0065450207,
-0.013597096,
-0.018454155,
-0.0064516156,
-0.019841887,
-0.031837754,
-0.024592198,
0.014531147,
-0.035734076,
-0.003899658,
0.012402847,
-0.010561435,
0.016612744,
-0.0019948636,
-0.009640728,
0.01645262,
-0.004396706,
0.02695401,
-0.015198325,
0.030423338,
0.02587318,
-0.017506763,
-0.02695401,
0.017079769,
-0.0052340147,
0.0014969816,
0.01749342,
0.034186225,
-0.018574247,
0.0057744295,
-0.009800851,
0.013130072,
0.011855761,
-0.014144183,
0.037628863,
-0.0010591458,
0.0016037301,
-0.00000416335,
-0.014904766,
-0.027834686,
0.014744644,
-0.010007677,
0.0055242376,
-0.0062381183,
-0.027007384,
-0.001333523,
0.0018063857,
-0.0032224718,
0.0131167285,
0.027941434,
-0.013003308,
-0.008566571,
-0.021069495,
-0.009300468,
0.017253235,
0.0055776117,
0.012943262,
-0.009113657,
0.008926848,
0.00094822736,
0.013343569,
0.025286064,
-0.018160596,
-0.0017663549,
0.02927579,
0.00091069855,
-0.01450446,
-0.008426464,
-0.0056810244,
0.018294033,
-0.023951706,
0.005017182,
-0.023564743,
-0.022737442,
-0.013663814,
0.029435914,
0.024285296,
0.012249396,
-0.00637489,
-0.028661987,
0.008853458,
-0.013597096,
-0.016132375,
0.0054875426,
-0.030610148,
-0.008546556,
-0.020068727,
0.011048475,
0.019308144,
0.0061413776,
0.011275316,
-0.010514732,
0.031197265,
-0.01547854,
0.0067385025,
0.01768023,
-0.027167507,
-0.008853458,
-0.0011041804,
-0.02568637,
-0.01884112,
0.0004244923,
-0.015318417,
-0.018280689,
-0.023204466,
-0.017186517,
0.047049426,
0.0149981715,
-0.020775937,
-0.0059078652,
0.0008218805,
0.015678693,
0.010448014,
-0.0010766592,
0.02751444,
-0.020362286,
0.015945565,
0.01962839,
0.0050872355,
-0.02060247,
0.0029606044,
-0.005567604,
-0.02639358,
0.0021533184,
-0.028395114,
-0.014277618,
0.011895792,
0.0039897272,
0.008266341,
-0.008726694,
0.003739535,
-0.025766432,
0.0064482796,
0.0068519227,
0.0062014237,
-0.016385904,
0.009614041,
0.010854993,
0.0035760766,
-0.0059945984,
0.004113155,
0.0002226708,
-0.0065416847,
-0.009654072,
-0.0062314468,
-0.024218578,
0.027541127,
-0.0032775141,
-0.016279154,
-0.00035694047,
-0.009127001,
-0.04288623,
0.015652006,
-0.007058748,
0.017319953,
0.01836075,
0.016986363,
-0.03410616,
-0.010087738,
0.00040968927,
0.025339438,
-0.0075724754,
-0.014851392,
0.024205234,
-0.0137305325,
0.009187047,
-0.01697302,
-0.0092270775,
-0.030716896,
0.026446953,
0.0029956312,
-0.01952164,
0.03375923,
0.0039763837,
0.0065883873,
-0.028661987,
-0.00042261585,
0.00916036,
0.017920414,
0.029542662,
-0.018774401,
-0.023671491,
0.02276413,
-0.0079861265,
-0.018120566,
0.0037228558,
0.0111618955,
0.006408249,
0.018600935,
-0.01196251,
-0.03466659,
0.011735669,
-0.013343569,
0.010421327,
0.018574247,
0.01282317,
0.01566535,
0.010327922,
-0.022243729,
-0.026366891,
0.0065350127,
-0.019081304,
-0.01697302,
0.005077228,
-0.0038796426,
-0.022230387,
-0.017973788,
0.005560932,
-0.030236527,
0.0010116093,
-0.029329164,
-0.0028588597,
-0.010054379,
0.022323791,
0.023124404,
0.023057688,
-0.021790048,
0.010461358,
-0.027247569,
-0.033332236,
0.006311508,
-0.011008444,
-0.008199623,
0.021256305,
-0.0008956871,
-0.0014602868,
-0.0020966083,
0.0071654967,
-0.02097609,
-0.00041385912,
-0.006972015,
0.1848885,
-0.028982231,
0.00035172814,
-0.009207062,
-0.014064122,
-0.0050572124,
-0.018574247,
0.009373858,
0.003712848,
0.00007229504,
0.015425166,
-0.0021399749,
0.010341266,
0.0044667595,
0.016105687,
-0.010741573,
-0.021376397,
-0.018520873,
-0.029115668,
-0.01809388,
0.0011625584,
-0.017186517,
0.01495814,
0.016519338,
0.023551399,
-0.0010674855,
-0.04123163,
0.017800322,
0.024819039,
0.00039717968,
-0.017293265,
-0.006528341,
0.005791109,
0.0010091075,
0.010995101,
0.0149981715,
-0.014597865,
-0.015985595,
0.013016651,
-0.013443646,
-0.027487753,
-0.0022250402,
-0.013230149,
0.006491646,
-0.00358942,
-0.006378226,
-0.018827775,
0.0004707778,
0.0044434085,
0.0022834183,
-0.051239304,
-0.0105547635,
0.031731006,
0.0067351665,
-0.015945565,
-0.026740512,
0.02265738,
0.005504222,
-0.013230149,
0.026500328,
0.0040764604,
0.0053674504,
-0.015772099,
0.029515974,
0.0046135387,
0.013470333,
-0.018934524,
0.012649704,
0.021376397,
-0.027941434,
0.011929151,
-0.014050778,
-0.032665055,
-0.008659977,
-0.016626086,
0.009440575,
0.023137748,
0.023031,
0.034346346,
0.014317649,
0.008286356,
0.014050778,
-0.01719986,
0.0105280755,
-0.022630693,
-0.03629451,
0.006625082,
0.030369963,
-0.0045334776,
-0.022870878,
0.011175239,
0.0070120455,
0.000773927,
-0.000988258,
0.026687138,
0.00077559496,
-0.00409314,
0.0011475469,
-0.014437742,
0.0051773046,
-0.011135208,
0.07376325,
-0.00811289,
-0.014811361,
-0.02014879,
0.008079531,
-0.019548329,
0.010221174,
0.014344336,
0.005974583,
0.022457227,
0.00026812233,
-0.013203462,
-0.006468295,
-0.00087984157,
0.023457995,
0.006741838,
-0.013029995,
0.026180083,
-0.026286831,
-0.030049717,
-0.021563208,
0.019281456,
0.026607076,
-0.007765957,
-0.0015753751,
-0.031997878,
0.0052840533,
0.010201159,
-0.023271184,
0.011869105,
-0.007305604,
-0.028048182,
0.039603714,
0.011875777,
0.018707683,
0.0165994,
-0.019761825,
-0.011495485,
0.005954568,
-0.025659682,
-0.0006905297,
0.0046135387,
0.009780836,
-0.018934524,
-0.0035060227,
0.023658147,
0.000112690606,
-0.01655937,
-0.016519338,
-0.010981757,
-0.023804927,
-0.03039665,
-0.02583315,
0.015545258,
-0.03367917,
-0.0039863912,
-0.026673794,
0.00278547,
-0.007826003,
-0.019081304,
0.0130700255,
0.026593734,
-0.009507293,
-0.00792608,
-0.012836513,
-0.16759522,
0.0027020727,
0.0005816962,
-0.013416959,
0.052920595,
0.005567604,
-0.023671491,
-0.0036728173,
0.0001920223,
0.02191014,
0.034853403,
-0.008926848,
-0.037548803,
-0.04064451,
-0.0027487753,
0.0027621188,
0.009520637,
0.036934998,
0.020322256,
-0.00687861,
0.0058611627,
-0.020522408,
0.032478247,
0.009967646,
-0.0019281458,
0.0047503104,
0.004797013,
0.00073306233,
-0.0023801592,
-0.006381562,
-0.026687138,
0.023498025,
0.031357385,
-0.007899392,
0.0039396887,
-0.0058845137,
-0.00315909,
-0.023498025,
0.008753382,
0.01095507,
0.027941434,
0.013036666,
-0.0137305325,
-0.012896559,
-0.024432074,
0.01121527,
-0.0019131342,
0.00687861,
0.027100788,
-0.0029856237,
0.026446953,
-0.01618575,
0.018213972,
0.02770125,
-0.0015303405,
0.005137274,
-0.0021416428,
-0.0007363982,
-0.0137705635,
0.0063381954,
0.006461623,
-0.017146487,
0.017960444,
0.013930686,
0.004830372,
-0.0406712,
-0.0150248585,
0.01618575,
-0.016292498,
0.0061413776,
-0.014237588,
-0.005424161,
0.024672259,
-0.014517803,
0.02037563,
0.02392502,
-0.0069586714,
0.013043338,
0.008172936,
0.018494187,
0.0039029939,
0.009340499,
-0.050412003,
-0.032504935,
-0.015998939,
-0.0015887187,
0.0034860075,
0.013463661,
-0.025966585,
-0.012496253,
0.023898331,
-0.025246032,
0.0011825738,
-0.0055542607,
0.026527015,
0.019174708,
-0.017827008,
-0.0071588247,
0.005300733,
0.008373089,
0.0015887187,
-0.0099342875,
-0.023084374,
0.03728193,
0.039496966,
0.0017096448,
-0.025219345,
-0.0024218578,
0.04931783,
-0.020455692,
-0.022670723,
-0.010661512,
0.022897564,
0.030049717,
-0.010027692,
0.008406448,
0.011568874,
-0.021936828,
-0.008386433,
-0.017453387,
0.05993931,
0.0033208807,
-0.007872705,
0.027434377,
-0.015571945,
-0.04512795,
-0.12628354,
-0.01529173,
-0.0058311396,
0.0009257101,
-0.013316882,
-0.0034793357,
0.006041301,
0.018774401,
-0.008800084,
0.026073333,
-0.019308144,
-0.00014969817,
0.0067351665,
-0.024445418,
0.024392044,
-0.008326387,
0.008980222,
0.0022834183,
-0.0080128135,
0.023137748,
0.004997167,
-0.010714886,
0.0071921838,
-0.0059045292,
0.0137305325,
-0.020629158,
-0.016492652,
0.044594206,
0.017173173,
0.025819806,
0.01753345,
0.0017413357,
0.02195017,
0.0023301207,
-0.004179873,
-0.0028154931,
-0.002847184,
-0.032024566,
0.0198152,
-0.0062714773,
-0.00018243161,
0.02247057,
0.015905535,
0.0027037407,
-0.00519732,
-0.019721795,
-0.012542955,
-0.009413888,
0.008566571,
-0.026246801,
-0.019855231,
-0.020629158,
-0.01327018,
-0.0030806966,
0.011735669,
-0.027994808,
-0.0023084374,
0.024632229,
-0.013577081,
-0.008700007,
-0.010141113,
-0.00068886176,
-0.012229381,
0.006461623,
0.033892665,
-0.02610002,
-0.020896029,
-0.030983767,
0.0198152,
-0.031304013,
-0.0017563473,
0.018427469,
-0.017093113,
-0.004540149,
-0.029489288,
0.0044667595,
-0.0043199803,
0.010214502,
-0.0040764604,
-0.003919673,
-0.0067685256,
-0.018574247,
0.01603897,
-0.0057710935,
0.057857715,
-0.016479308,
0.022684067,
-0.00035777444,
0.015371791,
-0.002822165,
-0.0018781073,
0.05398808,
0.011041803,
-0.0062814853,
-0.008533212,
-0.0034860075,
0.006211431,
-0.014878079,
0.008639961,
0.009066955,
-0.018267347,
-0.0026019958,
-0.06378226,
0.0065116617,
-0.019534985,
-0.00663509,
0.017266579,
-0.0039163376,
0.014424398,
-0.012289427,
-0.004363347,
0.04251261,
-0.01585216,
0.011235285,
-0.009547324,
-0.0075057577,
-0.016586056,
-0.012876544,
0.019548329,
-0.0021616581,
0.0071321377,
0.0406712,
-0.016906302,
-0.010301235,
0.0079594385,
0.008453151,
-0.021176243,
0.017506763,
0.007272245,
0.021816736,
-0.0023651477,
-0.013316882,
0.019681765,
-0.03973715,
-0.014931453,
-0.004063117,
-0.021202931,
-0.02276413,
-0.003806253,
0.02788806,
0.03674819,
0.042299114,
0.010514732,
-0.022550631,
0.009707446,
0.011168567,
0.03450647,
0.015158295,
-0.008780069,
0.015451853,
0.007879377,
-0.023377933,
0.029996343,
-0.0024502128,
-0.0025753088,
-0.014838048,
-0.011348706,
0.015918877,
-0.00725223,
-0.022297103,
-0.019641733,
-0.011355377,
0.010021021,
0.009967646,
0.005817796,
0.021603238,
0.0023434644,
0.004706944,
-0.010141113,
-0.025192657,
0.00075057574,
-0.0398439,
-0.016279154,
-0.0035360458,
0.012723093,
0.0111618955,
0.013203462,
0.0022700746,
-0.016119031,
0.017960444,
-0.012542955,
0.011408752,
0.00089401915,
-0.00006405955,
-0.020175476,
0.010448014,
0.03159757,
-0.0043099727,
0.0056876964,
0.009634057,
0.0011542187,
0.00564433,
-0.014531147,
0.035173647,
0.015638663,
0.012976621,
-0.003155754,
0.010054379,
-0.0011350373,
-0.018734371,
-0.0051205945,
0.012402847,
-0.018934524,
0.023191122,
-0.02112287,
-0.020268882,
-0.017213205,
0.018374095,
-0.023764897,
-0.046035312,
-0.020455692,
-0.0019414893,
0.0069519994,
0.017133143,
-0.0012809826,
0.0049404562,
0.0034292971,
0.015198325,
0.009740805,
0.0009465594,
0.003340896,
0.02718085,
0.01510492,
0.023724865,
0.010181143,
-0.011015116,
0.021056151,
0.009173703,
0.03367917,
-0.005357443,
0.030823644,
-0.02991628,
0.03906997,
-0.015758755,
-0.054708634,
-0.01072823,
-0.0060846675,
-0.026500328,
0.002882211,
0.0036327867,
-0.010401312,
0.08950866,
0.016626086,
-0.016305842,
0.014878079,
-0.0060779955,
0.0045368136,
0.01906796,
0.009660744,
0.008506525,
-0.03234481,
0.016666118,
-0.011021788,
0.00013718857,
-0.055135626,
-0.008212967,
0.012389503,
-0.011762356,
-0.014864736,
0.009080298,
-0.0043166447,
0.013416959,
-0.002415186,
-0.0032641706,
0.028128244,
-0.029409226,
0.0066117384,
0.014037435,
0.016159061,
0.010101082,
-0.019494954,
0.012409519,
-0.016105687,
-0.03850954,
-0.015585288,
0.020682532,
-0.023791583,
-0.029756159,
-0.024965817,
0.025739744,
0.013263508,
-0.028688673,
0.0064582876,
-0.023324559,
-0.018947868,
-0.014624552,
-0.019895261,
-0.008806756,
-0.0023401284,
0.0072055273
] |
Cancer chemoprevention involves the chronic administration of a synthetic, natural or biological agent to reduce or delay the occurrence of malignancy. The potential value of this approach has been demonstrated with trials in breast, prostate and colon cancer. The paradigm for developing new chemopreventive agents has changed markedly in the last decade and now involves extensive preclinical mechanistic evaluation of agents before clinical trials are instituted and a focus on defining biomarkers of activity that can be used as early predictors of efficacy. This review will summarise the current status of the field of chemoprevention and highlight potential new developments. | [
0.0026342943,
-0.005553643,
-0.003055323,
-0.027496267,
0.0015800851,
0.016710076,
-0.007876672,
-0.0015260231,
-0.026670594,
-0.009134842,
0.0044822325,
0.005081829,
-0.0075817876,
0.0035254986,
-0.017155679,
0.0137219215,
0.056670096,
-0.015215999,
-0.01673629,
-0.0036074107,
-0.036382098,
0.008256744,
-0.009750822,
-0.006369488,
-0.010864826,
0.015124258,
0.022686386,
-0.06327549,
-0.0010411033,
0.020956403,
0.0012671808,
0.005229271,
-0.0022050748,
-0.01667076,
0.007666976,
0.00030368927,
0.013682604,
0.0054946663,
0.0037548526,
-0.008794087,
-0.009416619,
0.020261787,
0.011126945,
-0.0048917932,
-0.014796609,
-0.0038007232,
0.023983875,
-0.025215833,
-0.02739142,
0.010026046,
0.030746542,
0.021533063,
-0.015714025,
0.002083845,
0.008944806,
-0.020484589,
0.0036794934,
0.04809881,
0.0041807955,
-0.02574007,
-0.02564833,
-0.009606656,
-0.026736123,
0.009888434,
-0.010609261,
0.007050997,
-0.003935059,
0.02079913,
0.0002387739,
0.008132237,
0.020786025,
0.037718903,
0.0042594313,
-0.016015463,
0.021284051,
-0.00052710465,
-0.037535418,
0.0009362558,
0.0115659945,
0.006808537,
0.02037974,
-0.0046263975,
0.009940857,
0.022856764,
0.016369322,
0.014101994,
-0.0019183824,
-0.008590945,
0.013538439,
-0.012005043,
0.021821395,
0.0029160723,
0.0036008577,
0.025923554,
-0.007843907,
0.03937025,
0.009862222,
0.027181724,
0.019999668,
-0.035123926,
0.014075782,
-0.0052259946,
0.012719317,
-0.007241033,
-0.028361259,
0.019658914,
-0.010006387,
0.017693022,
0.021323368,
-0.004049736,
-0.014953881,
0.04353794,
-0.0044920617,
-0.024206676,
0.024599854,
-0.024534324,
0.0050294055,
0.0010951653,
-0.0015186511,
-0.004292196,
0.012332692,
0.0027342273,
0.040576,
-0.030877601,
0.019554066,
-0.024272205,
-0.012077126,
-0.012706211,
-0.0047443514,
0.0005897674,
-0.0034894573,
0.01508494,
0.024245994,
0.033000764,
-0.03669664,
0.009429726,
-0.021113673,
-0.021349581,
-0.029907761,
-0.036932547,
-0.0032371678,
0.023341684,
-0.0028489043,
-0.005943545,
-0.020838449,
0.009711503,
0.017575068,
0.014324795,
-0.0020822065,
0.0005135891,
0.0022525839,
-0.013361508,
0.0071689505,
-0.002490129,
-0.008853064,
0.009272454,
-0.0007109974,
0.0075948937,
0.0020494417,
-0.010124341,
0.03394439,
-0.024665384,
0.017430903,
0.0010640387,
-0.0076735294,
0.01737848,
0.007909437,
0.010163658,
-0.007332775,
-0.0021297156,
0.020628754,
0.039291617,
-0.017653704,
0.014429643,
-0.044874746,
0.0033272712,
0.0059664804,
0.022227678,
-0.0027653538,
-0.020248681,
-0.002191969,
0.0006065594,
0.0051506353,
-0.0034861807,
-0.0007683359,
-0.005376713,
0.01382677,
0.0014531214,
-0.02199177,
-0.028518531,
0.0038236587,
0.028623378,
-0.01212955,
-0.02503235,
-0.64166695,
-0.046106707,
-0.00069543405,
-0.014875244,
0.019685125,
0.03129699,
0.030536845,
-0.023210624,
-0.021664122,
0.028754437,
0.00014088888,
-0.0015039069,
-0.0014916201,
-0.0044232556,
0.000029641957,
-0.03672285,
-0.015294635,
-0.04348552,
0.027863234,
-0.0059664804,
-0.03113972,
-0.004600186,
-0.048465777,
0.008210873,
0.0019724444,
0.0076473174,
0.014455855,
-0.011002439,
0.017011514,
0.042253558,
-0.0003124948,
0.0070444443,
-0.006762666,
0.013132154,
0.041388568,
0.0041578603,
0.0035517104,
0.011585653,
0.023865921,
0.02377418,
0.0030307493,
0.014455855,
0.027889445,
-0.003879359,
-0.043302033,
0.015294635,
0.0346259,
-0.0040595657,
-0.011703607,
0.012214739,
0.009292114,
0.024508113,
-0.012987989,
-0.0035254986,
0.011592207,
0.015176682,
0.029907761,
-0.026749229,
0.0049278345,
0.0074572815,
-0.010307824,
0.0098425625,
0.0018921704,
-0.041781746,
-0.022633962,
0.033289094,
-0.013839875,
0.005861633,
-0.0071558445,
0.011244899,
0.01261447,
0.026578851,
-0.009141395,
-0.03184744,
0.027863234,
0.0153863765,
-0.0007224651,
0.0029701341,
-0.011716712,
0.012804505,
0.008191214,
0.013420485,
-0.037247088,
0.022712598,
0.042620525,
-0.0074572815,
-0.01828279,
0.00037188112,
0.01947543,
-0.007293457,
0.018610438,
0.0067561134,
-0.017194996,
-0.0315329,
-0.00952802,
0.0036991523,
0.028859286,
0.017273633,
-0.008191214,
-0.0047214157,
-0.026539534,
-0.028597167,
0.007070656,
0.011343193,
0.013931617,
-0.008191214,
-0.016447958,
0.009501808,
0.037692692,
-0.026277415,
0.016854241,
0.007857013,
-0.030143667,
-0.010989333,
0.0024164082,
-0.009934304,
-0.007739059,
0.006867514,
-0.0056584906,
-0.046945486,
0.021244733,
0.010124341,
0.0007544108,
-0.012345797,
0.030143667,
0.006077881,
0.002529447,
-0.0046788217,
-0.008944806,
-0.024809549,
0.034573477,
0.0011508656,
-0.009573891,
-0.0039022944,
0.014901456,
-0.019213311,
0.005606067,
-0.0065529714,
-0.020681176,
0.0082895085,
-0.017548857,
-0.011880537,
0.0008264935,
0.024245994,
0.004154584,
-0.010085023,
-0.041650686,
0.01446896,
-0.035176348,
0.0008428759,
0.017430903,
0.007870118,
0.0005766615,
0.022712598,
0.027627327,
-0.0036336225,
0.023931451,
-0.019934138,
-0.016395533,
-0.014560702,
0.006212217,
-0.0021886923,
0.00416769,
-0.009731162,
-0.009416619,
0.0072279274,
0.024363948,
0.026211886,
-0.013053519,
-0.050510302,
-0.0031274054,
-0.029435948,
-0.0231582,
0.021572381,
0.0009231498,
0.014940774,
-0.022502903,
-0.002098589,
0.010327483,
-0.003271571,
-0.004610015,
-0.019226417,
-0.0061499635,
0.012339245,
0.02864959,
-0.013944723,
0.045267925,
0.004393767,
0.00024205037,
0.027260361,
0.007758718,
0.019134676,
-0.007083762,
-0.010137446,
-0.007555576,
-0.018243471,
-0.014914563,
0.0044920617,
0.005153912,
0.018007565,
0.030667905,
-0.0010583048,
0.010347142,
-0.030274726,
0.005019576,
-0.032083347,
0.003427204,
0.017273633,
0.012712765,
-0.017077044,
-0.0024245994,
0.005665044,
-0.02796808,
-0.0021641187,
-0.007758718,
-0.0022837105,
-0.026054613,
-0.023695543,
-0.011697054,
-0.020589435,
-0.005324289,
-0.020654965,
0.011913301,
-0.04018282,
-0.020274892,
0.026591957,
0.0117101595,
0.010687896,
-0.017627493,
-0.012817612,
-0.010183318,
0.006579183,
-0.003718811,
0.011113839,
0.021873819,
0.015530542,
0.0027506098,
-0.008191214,
0.037797537,
0.01556986,
-0.0020019328,
-0.00603201,
0.016749395,
0.034678325,
0.015818873,
-0.0069264905,
0.029593218,
0.03016988,
-0.007549023,
0.021100568,
-0.0028243307,
0.0122540565,
-0.024442583,
-0.015163575,
-0.008735111,
-0.008990676,
0.0069264905,
0.027338997,
0.049566675,
0.028413683,
0.043275822,
-0.00012645187,
-0.0053799893,
-0.0077980356,
0.0091545,
-0.0013892299,
0.02536,
0.009947411,
-0.0071427384,
0.004013695,
-0.009980176,
-0.019580279,
0.01815173,
-0.04393112,
0.006408806,
0.026015297,
-0.0069527025,
0.022568433,
0.023367895,
-0.0025032351,
-0.022882976,
-0.011087627,
0.024377054,
0.019816184,
-0.017299844,
-0.017968247,
-0.013839875,
0.012942119,
0.00205108,
-0.012732423,
0.006611948,
0.008990676,
-0.010484754,
0.011067969,
0.0017250697,
-0.021755865,
0.01841385,
0.011153157,
0.011703607,
-0.02390524,
0.0011213772,
-0.010792743,
0.013033859,
-0.012758635,
0.028754437,
0.008158449,
0.015491224,
-0.005986139,
-0.04162447,
-0.029671853,
0.002853819,
0.00410216,
0.008879276,
-0.022135938,
0.00064055296,
0.012640681,
0.00029467893,
0.0062842993,
-0.004128372,
-0.022175254,
-0.0038465941,
-0.030615482,
0.0049638757,
0.013433591,
0.030615482,
-0.0063957,
0.006828196,
0.024744019,
0.016644547,
0.016867349,
0.0111924745,
-0.0083746975,
0.008348485,
-0.0035386044,
-0.025923554,
0.021166097,
-0.0028079483,
0.013164919,
0.0054062014,
0.009488703,
-0.017679917,
-0.024508113,
-0.001390049,
-0.00054594444,
0.026723016,
-0.020720495,
0.03187365,
0.022489797,
0.03698497,
-0.004016971,
0.024730913,
0.016710076,
-0.0024114933,
0.011146604,
-0.0053668832,
0.005586408,
0.00027338177,
0.010163658,
-0.008669581,
-0.024075616,
0.02428531,
0.025464846,
0.0027293125,
-0.006267917,
0.018177941,
0.008001178,
0.011107286,
0.003912124,
-0.009947411,
-0.016028568,
0.0070444443,
0.0042070076,
-0.015098046,
-0.016264474,
-0.0046526096,
-0.0015415865,
-0.01049786,
-0.016723182,
0.024298418,
0.027260361,
0.015779555,
-0.01206402,
-0.02009141,
-0.004541209,
-0.015399482,
-0.028203988,
0.015465012,
-0.004190625,
-0.0010787828,
-0.017457115,
-0.0207336,
0.0071558445,
0.013879193,
0.0016349663,
0.014560702,
-0.005389819,
-0.0032469973,
0.0056158965,
0.020523906,
0.0015022687,
0.0055896845,
-0.026801653,
-0.01954096,
0.026631275,
-0.0038465941,
-0.028308835,
-0.0041840724,
-0.035386045,
0.006913385,
0.008964465,
0.006212217,
-0.009029995,
-0.03853147,
0.021297157,
-0.005923886,
-0.023682438,
0.011677395,
0.0044691265,
-0.021755865,
-0.012044361,
-0.0016791989,
0.013138708,
0.010111235,
-0.034992866,
-0.020065198,
0.0146131255,
-0.011631524,
-0.02454743,
-0.004999917,
0.004085778,
0.0015522351,
0.016683865,
-0.01841385,
-0.00334693,
0.021257838,
-0.00754247,
0.014993198,
-0.015425694,
-0.009226584,
-0.007942202,
0.003892465,
0.015438801,
0.010163658,
0.003987483,
-0.009953964,
0.013433591,
0.013020754,
0.024455689,
-0.020405952,
-0.017561963,
-0.011271111,
-0.016841136,
-0.034127872,
0.010248847,
-0.01912157,
0.024154251,
-0.021152992,
-0.03404924,
-0.029776702,
0.008073261,
-0.002717845,
0.006821643,
-0.013033859,
-0.018859452,
-0.015111152,
0.0027473331,
0.011074522,
-0.013164919,
0.03604134,
-0.024154251,
0.0016824753,
-0.0057600616,
-0.019160887,
0.00091987336,
-0.013459803,
0.005013023,
-0.021637911,
-0.006828196,
-0.023249943,
-0.018964298,
-0.006281023,
-0.0036925992,
0.04809881,
0.025504164,
-0.003777788,
-0.021139884,
-0.005802656,
0.0068019843,
0.012385116,
0.0013171472,
-0.022437373,
0.027365208,
-0.013669498,
0.027601115,
0.0025114263,
-0.0052784183,
0.0044789556,
-0.011375958,
0.036618,
0.01272587,
0.0036303462,
-0.026893394,
-0.011618418,
-0.0152422115,
-0.03559574,
0.023564484,
-0.0040988834,
0.007129633,
-0.033000764,
0.000008703165,
0.016303793,
0.034835596,
0.005104765,
-0.00007244105,
0.011356299,
0.006120475,
-0.028466107,
-0.011697054,
-0.0064120824,
-0.032528948,
-0.018479379,
-0.009881881,
-0.0216117,
0.0019265736,
0.0022247338,
0.010714108,
0.026474005,
-0.036906336,
-0.016172733,
0.0053472244,
-0.020130727,
-0.0056781494,
0.008859617,
-0.020838449,
-0.015451906,
0.012385116,
0.0037155347,
-0.028125353,
-0.0096132085,
0.01332219,
-0.008649922,
0.01973755,
-0.013787451,
0.0071689505,
0.007096868,
-0.029567007,
0.0133746145,
-0.043852482,
0.051847108,
0.008407462,
-0.0063432762,
0.006110646,
-0.0003606182,
-0.012339245,
0.023407213,
0.024652278,
0.020615648,
0.0077980356,
-0.01592372,
-0.02397077,
0.015425694,
-0.027915658,
-0.036486942,
0.019842397,
0.010294718,
0.024049405,
-0.028072929,
-0.02225389,
-0.01091725,
0.022516008,
0.014337901,
-0.009731162,
0.01087138,
-0.043721423,
-0.022974716,
0.00730001,
-0.020065198,
0.020851554,
0.0029914314,
-0.009639421,
-0.0059075034,
-0.022660175,
0.03127078,
-0.0046198447,
-0.004085778,
0.025281362,
0.02322373,
-0.0048328163,
0.0044363616,
-0.0010992609,
-0.0038465941,
0.0038203823,
0.0012467027,
0.042672947,
0.006510377,
0.005402925,
0.017601281,
0.00060492114,
0.00019136723,
-0.0010607622,
-0.016644547,
-0.010550284,
-0.03546468,
-0.012535834,
0.012385116,
0.024114935,
-0.0346259,
0.0097835865,
0.0026342943,
0.012339245,
-0.012208185,
-0.013918511,
-0.0032420824,
-0.017142573,
-0.012476857,
-0.03045821,
0.013178025,
0.02432463,
0.015294635,
-0.009908092,
-0.013997147,
0.011330088,
-0.0069068316,
0.0008207596,
0.0044494676,
0.0090365475,
-0.011284216,
0.01660523,
-0.027417632,
-0.01863665,
0.0065726303,
-0.010327483,
-0.03140184,
-0.031218356,
-0.0060614985,
0.006140134,
-0.00014508687,
-0.015753344,
0.010530625,
0.006484165,
0.015478118,
-0.00868924,
-0.02920004,
-0.00039338306,
-0.021297157,
0.013643286,
0.032607585,
-0.02529447,
0.008053602,
-0.008774429,
-0.010340588,
0.017208103,
0.004016971,
-0.0016218604,
-0.03016988,
-0.00012204909,
-0.00093543663,
-0.010491307,
-0.010006387,
0.0045706974,
-0.015805766,
0.019619595,
-0.0004210284,
0.0056584906,
-0.011801901,
-0.0067561134,
-0.0065824594,
-0.009881881,
-0.027312784,
-0.009881881,
-0.021716546,
-0.0282302,
-0.014849033,
-0.0037679584,
-0.008276403,
0.019816184,
0.027601115,
-0.017286738,
-0.02781081,
-0.04311855,
-0.03362985,
-0.022240784,
0.010445436,
0.016159628,
-0.014573808,
0.02697203,
-0.010642026,
0.03389197,
-0.007516258,
0.004200455,
0.018597333,
-0.008414015,
0.019357476,
-0.026251202,
0.037509207,
0.017234314,
-0.039737217,
-0.007883225,
0.039527524,
-0.014324795,
-0.011919855,
0.010786191,
-0.014364113,
0.00344031,
-0.020812236,
0.008466438,
0.022293208,
0.0043970435,
0.03213577,
-0.0115659945,
0.0014613126,
0.002644124,
-0.007863565,
-0.0071689505,
0.0049376637,
-0.017194996,
-0.00027747737,
0.016683865,
-0.0063924235,
-0.0432234,
0.016080992,
-0.017194996,
-0.008328826,
0.016998406,
0.020052092,
0.00019372221,
-0.0008527054,
0.0052816947,
-0.018177941,
-0.025333786,
-0.007437622,
-0.021952454,
0.008741664,
0.017326055,
-0.0039907596,
-0.008898935,
-0.009750822,
-0.004999917,
0.006303958,
-0.0107337665,
-0.0023082842,
-0.00048000514,
0.03129699,
0.0057272967,
-0.0009051291,
-0.012155762,
-0.004131648,
-0.03003882,
-0.014259266,
-0.014062677,
-0.011441488,
-0.027181724,
0.002706377,
0.00669386,
-0.0012016511,
0.0067233485,
-0.010419224,
0.0013990593,
-0.007208268,
0.029383523,
0.16723183,
-0.023236835,
-0.0039842064,
0.033000764,
-0.0017840464,
0.0039973124,
0.0368277,
0.017679917,
-0.01711636,
0.008178108,
0.044586416,
-0.006566077,
-0.002888222,
-0.00077816535,
0.029173829,
-0.019527854,
-0.010825508,
-0.011487358,
0.007522811,
0.002286987,
0.0011181007,
0.007981519,
0.015333952,
-0.004324961,
0.00063522864,
-0.009849116,
0.0017381756,
0.026054613,
0.024049405,
-0.00633017,
-0.017063936,
0.011303876,
0.011375958,
0.011873984,
-0.0015899147,
-0.000036399706,
-0.012332692,
-0.017588174,
-0.009088971,
-0.009888434,
-0.0018135348,
0.030641694,
-0.025281362,
-0.014088889,
0.017719233,
0.030877601,
-0.0029160723,
-0.016749395,
0.016251368,
0.0046329508,
-0.046499886,
0.009685292,
0.02809914,
0.02280434,
-0.016998406,
0.01007847,
0.022070408,
-0.005629002,
-0.0031355966,
0.03155911,
-0.012797953,
-0.017457115,
-0.030903812,
0.020812236,
-0.0060614985,
0.03438999,
-0.024363948,
-0.0191871,
0.0058124857,
-0.012889694,
-0.011061415,
-0.020654965,
-0.020261787,
0.009999834,
0.014246159,
-0.013191131,
0.031323202,
0.021860711,
0.0255828,
0.007358987,
-0.0056093433,
0.0037974468,
-0.027627327,
0.0149276685,
-0.0023967493,
-0.018531803,
0.016120309,
-0.007326222,
-0.01812552,
0.020484589,
-0.018689074,
-0.0060483925,
-0.013669498,
0.0013064987,
0.027705962,
-0.011389064,
-0.004472403,
0.028151564,
0.002421323,
0.0039022944,
-0.05103454,
0.09918577,
-0.004095607,
0.023276154,
-0.005422584,
0.013590862,
-0.014888351,
0.0098425625,
0.0069527025,
0.0258056,
0.0076079997,
-0.0146131255,
0.0032830385,
-0.029278675,
-0.012693105,
0.029121405,
0.011290769,
-0.036618,
0.0083746975,
-0.013852981,
-0.009986728,
-0.032607585,
-0.023446532,
0.027784599,
-0.009914646,
-0.009469043,
-0.036382098,
-0.0039907596,
0.0089317,
-0.008735111,
-0.01404957,
0.004878687,
-0.0035123925,
0.013879193,
0.0051211473,
-0.005032682,
0.013433591,
0.002341049,
-0.0096132085,
0.016080992,
-0.02335479,
-0.010877932,
-0.0023082842,
0.023761073,
0.020196257,
-0.0017660258,
-0.014455855,
0.0032863151,
-0.012640681,
-0.011598759,
0.0061073694,
-0.010419224,
-0.009115183,
0.014835927,
0.02412804,
-0.043013703,
-0.0015890956,
-0.026591957,
0.020458376,
0.008282956,
-0.021926241,
-0.00017334656,
0.011487358,
-0.008551627,
0.0008359134,
0.01460002,
-0.16261853,
0.00065038237,
0.028570954,
-0.030641694,
0.014062677,
0.0076276585,
0.013656392,
-0.01792893,
-0.008066707,
-0.007450728,
0.014626232,
-0.0061368574,
-0.033026975,
-0.024809549,
0.03003882,
0.003305974,
-0.007857013,
0.0489638,
0.030641694,
0.0036074107,
0.016172733,
-0.0032748473,
0.01572713,
-0.02412804,
0.007129633,
0.013263213,
-0.0004877868,
-0.008604052,
-0.012994542,
0.004236496,
-0.0054062014,
0.011081074,
0.013132154,
-0.0099277515,
0.01585819,
0.0012319586,
0.0007494961,
-0.006100816,
-0.019003617,
0.0037286407,
0.024311524,
0.02328926,
0.0010181679,
-0.007286904,
-0.022987824,
0.00002833648,
0.026054613,
-0.02904277,
0.021795182,
-0.0027571626,
0.0207336,
0.023079565,
0.0025065115,
0.00458708,
0.009999834,
0.0010689534,
-0.008695792,
-0.0043741083,
0.0015907338,
0.016749395,
-0.005422584,
-0.010956568,
0.015373271,
0.011258004,
-0.011697054,
-0.011913301,
-0.0069068316,
0.013748134,
-0.016657652,
0.012588258,
-0.015910614,
0.017955141,
0.017588174,
-0.006808537,
0.024245994,
-0.0010173488,
-0.0066643716,
0.0052948007,
-0.011978831,
0.008767876,
-0.017430903,
-0.013839875,
-0.007968413,
-0.012162315,
0.011703607,
0.0216117,
0.028859286,
0.014495173,
-0.004918005,
-0.003663111,
-0.0005672416,
-0.0054094777,
-0.011821561,
-0.027627327,
0.004338067,
0.035254985,
-0.007883225,
0.00055618346,
-0.0047771162,
-0.023407213,
0.0130600715,
-0.03171638,
-0.013073178,
-0.004383938,
0.0061728987,
0.016723182,
0.004426532,
0.0015391291,
0.032083347,
0.0022722427,
-0.012476857,
0.015098046,
-0.000337478,
0.018453168,
0.0023508784,
0.036224823,
0.011369405,
0.00044764986,
-0.025438635,
-0.019711338,
0.039134346,
-0.0005664225,
0.025333786,
0.02273881,
0.0058976742,
-0.014364113,
-0.14133449,
-0.014429643,
0.0003149522,
0.009115183,
0.0038171057,
0.026041508,
-0.009914646,
0.00928556,
-0.020235576,
0.023105776,
0.0003305155,
-0.0038007232,
-0.012437539,
-0.015491224,
0.010052258,
0.0024819379,
-0.0095542325,
-0.024232889,
-0.0033354624,
0.0180862,
-0.0076473174,
-0.019567173,
-0.00789633,
-0.017810976,
-0.002118248,
0.01369571,
0.0014809715,
0.01515047,
-0.0024114933,
0.0169853,
-0.008099472,
-0.004957323,
0.007103421,
-0.017391585,
0.000479186,
-0.012483411,
0.00271293,
-0.03630346,
0.029016556,
-0.025333786,
-0.006533312,
0.0049016224,
0.012889694,
0.007345881,
0.037902385,
-0.040235244,
-0.017614387,
0.021035038,
-0.002516341,
-0.0040562893,
-0.016788712,
-0.011146604,
-0.024429478,
0.006647989,
0.019842397,
-0.023656227,
0.008178108,
0.017653704,
0.00022239146,
-0.0057404027,
-0.015451906,
0.002631018,
-0.032555163,
0.013230449,
0.027207937,
-0.009934304,
-0.0033026976,
-0.0147835035,
0.0002533133,
-0.03465211,
-0.0034009921,
-0.00022443927,
-0.022450479,
0.02106125,
-0.014770397,
0.001969168,
0.0062646405,
-0.009377302,
0.032738645,
-0.024573643,
0.0028914986,
-0.014429643,
0.010668237,
-0.025910448,
0.029016556,
0.0016300516,
0.006058222,
-0.0059894156,
0.003299421,
-0.009731162,
-0.010622366,
0.039527524,
-0.019934138,
-0.020288,
0.0025212558,
-0.006647989,
0.009023441,
-0.025884237,
0.019396795,
0.028597167,
-0.015202893,
-0.011749477,
-0.044979595,
-0.008106026,
0.03182123,
0.0077194003,
-0.00046034623,
-0.010183318,
0.027103089,
-0.012457198,
0.009029995,
0.008407462,
-0.02432463,
0.011041757,
-0.0013466356,
-0.008590945,
-0.01724742,
-0.018322108,
0.030903812,
0.007994625,
0.025792494,
0.004095607,
0.012260609,
-0.01261447,
0.04558247,
-0.021952454,
-0.013918511,
0.009462491,
0.008472992,
0.018780816,
-0.013237002,
-0.0039219535,
-0.0049343873,
-0.01667076,
0.0019151059,
0.007345881,
-0.006192558,
-0.004852475,
-0.0048557515,
0.022358738,
0.008466438,
0.043721423,
-0.01398404,
-0.015333952,
0.018767709,
0.002191969,
-0.004682098,
-0.009521468,
-0.04340688,
0.0053406716,
0.020366635,
-0.0040431833,
0.03640831,
-0.0077062943,
-0.0026293797,
-0.017666811,
-0.014980093,
-0.0109041445,
0.013459803,
-0.010681343,
-0.021886924,
-0.040549785,
0.007450728,
0.035202563,
-0.018675968,
0.016788712,
-0.00083509425,
-0.04047115,
-0.019921033,
-0.027312784,
0.017142573,
-0.013191131,
-0.012221292,
-0.010576496,
0.005881292,
-0.0028095865,
0.0014965348,
-0.027312784,
-0.024966821,
-0.007837353,
0.0038891884,
0.028439894,
0.013125601,
-0.0076014465,
-0.008800641,
0.030694118,
0.021205414,
0.022201467,
-0.026893394,
-0.004691927,
-0.01779787,
-0.0060614985,
0.013328743,
-0.004082501,
0.024848867,
0.01792893,
0.005222718,
0.00410216,
0.010006387,
0.012470304,
-0.0035943047,
0.02432463,
0.0061728987,
0.017457115,
-0.010799296,
0.008348485,
-0.02066807,
-0.0036074107,
-0.02529447,
-0.011146604,
-0.024966821,
0.02148064,
0.032974552,
-0.0045838035,
0.008079814,
-0.006657819,
-0.028413683,
0.037482996,
-0.00063645735,
-0.01321079,
-0.012162315,
0.041650686,
-0.005746956,
0.010936909,
0.014796609,
0.0021411832,
0.020235576,
-0.0073917517,
0.010085023,
-0.023341684,
0.015438801,
0.009606656,
0.011054862,
-0.011264558,
-0.029855337,
-0.0066905837,
-0.0258056,
0.0076276585,
0.02064186,
-0.0006499728,
-0.015032516,
0.057404026,
0.017391585,
-0.02041906,
0.012437539,
0.0012344159,
0.017470222,
0.011290769,
0.01912157,
-0.016028568,
-0.013243555,
0.0031487027,
-0.008551627,
0.009121736,
-0.02781081,
-0.028125353,
0.02196556,
-0.014324795,
0.022463586,
-0.011284216,
-0.018387638,
0.019357476,
-0.0059107803,
0.00093461754,
0.019947244,
-0.04338067,
-0.0022394778,
0.0061630695,
-0.018295895,
0.020209363,
-0.016185839,
-0.009075865,
0.010314377,
-0.008341933,
-0.022529116,
0.0045936326,
0.019789973,
-0.0038367647,
-0.019514749,
0.015137363,
0.02904277,
-0.002380367,
0.040628422,
-0.017194996,
-0.033262882,
-0.025556589,
0.008787534,
-0.02300093,
-0.036801487,
-0.005458625
] |
Dengue virus and its four serotypes (DENV 1-4) infect approximately 390 million people worldwide each year, with most cases in tropical and subtropical regions. Because of repeated introduction of DENV from epidemic regions and suitable weather conditions, many regions have shifted from hypo-endemicity to hyper-endemicity over recent decades. Since the first dengue outbreak in 1978, it is crucial to understand the current situation in China over nearly 40 years. The purpose of the study was to examine whether dengue in China was endemic or not, which is essential for relevant dengue control and prevention | [
0.004808057,
0.012446275,
-0.0069338935,
-0.018717654,
-0.018576145,
-0.0023123699,
-0.016183373,
-0.0054866523,
-0.026963713,
-0.0071654525,
-0.018769111,
0.012562054,
-0.004637604,
0.027504016,
0.0020084493,
0.012832206,
0.034399316,
-0.006625149,
0.015192817,
-0.0042130803,
-0.03939069,
0.028507438,
-0.0016329705,
0.0053869537,
-0.011738734,
0.037126563,
0.010677424,
-0.033241525,
0.0071590203,
0.010716017,
0.006625149,
0.006493289,
-0.018563282,
-0.010420137,
-0.008059526,
-0.019695345,
-0.0077893743,
-0.011217728,
0.0060108756,
-0.0039879535,
0.021522086,
0.020878868,
-0.002590562,
-0.00092784245,
0.004939917,
0.011886675,
0.023696164,
-0.016620763,
-0.0115136085,
0.021264799,
0.023297368,
0.02415928,
-0.04000818,
0.009744758,
-0.038155712,
-0.013102357,
-0.014922665,
-0.014485277,
0.010008478,
-0.041757736,
-0.011571498,
0.00652545,
-0.020570122,
-0.0027819194,
-0.026449138,
0.02123907,
-0.006313188,
0.007885857,
0.025497176,
0.021213342,
0.04371312,
0.021071833,
0.017392624,
-0.0010371896,
0.00771862,
-0.023323096,
0.0061073583,
0.004451071,
-0.0023573951,
0.010999033,
0.019695345,
-0.0002954784,
-0.003399409,
0.008509778,
0.0063260524,
0.0137391435,
-0.011963861,
0.025973156,
0.009230183,
-0.0037853399,
-0.011655116,
-0.013842058,
-0.0068631396,
0.004232377,
-0.00085789245,
0.0058339904,
0.005679618,
0.0214449,
0.0046118754,
-0.008503347,
-0.0063228365,
-0.0021226206,
-0.010413705,
-0.018576145,
-0.025291346,
0.023438876,
0.029433671,
-0.020518664,
0.012008887,
-0.011320643,
-0.031363327,
0.03416776,
-0.0061523835,
-0.042941257,
0.016839456,
-0.02662924,
0.032829866,
-0.00497851,
0.007113995,
-0.0040233308,
0.0020711632,
0.03046282,
0.009455309,
-0.0077572134,
0.022100983,
0.0005475396,
-0.011629388,
-0.0065029375,
0.0026098585,
0.0009181942,
-0.0053580087,
0.02153495,
0.03722948,
0.003402625,
-0.02548431,
0.037924152,
-0.028147236,
0.008979328,
-0.014009296,
-0.033473082,
0.0072040455,
0.018550416,
-0.018820569,
-0.009236615,
0.024622397,
0.01340467,
0.025149837,
0.02244832,
-0.004177703,
-0.014974123,
0.011629388,
-0.007808671,
0.032624036,
0.021161884,
-0.0051103695,
0.009152997,
-0.007332689,
0.01502558,
-0.008992192,
0.015154224,
-0.004245241,
-0.007744349,
-0.017456945,
0.005004239,
-0.0056956983,
0.01593895,
0.002762623,
0.00024663404,
-0.002072771,
-0.033292983,
-0.01867906,
0.024210738,
-0.017405488,
0.008734905,
0.018769111,
0.020184191,
0.0015573924,
0.018537553,
-0.022576964,
-0.008393999,
-0.022191033,
0.017109608,
0.013854923,
-0.0027835274,
-0.02174078,
-0.0021965906,
0.024841093,
0.00012050293,
0.016029,
-0.0029861412,
0.0054963008,
0.008586965,
0.038593102,
0.0072040455,
-0.6471291,
-0.014974123,
0.004348156,
0.011893108,
0.0006496505,
-0.008258924,
0.016787998,
0.00067899737,
-0.015591613,
0.028790453,
-0.028610352,
-0.035042536,
0.005676402,
-0.0274011,
-0.021869423,
-0.015913222,
-0.01340467,
0.0029555883,
-0.013842058,
-0.007371282,
-0.008593397,
0.028301608,
-0.022255355,
0.02244832,
-0.012234013,
-0.0026773964,
-0.001821916,
-0.037075106,
0.019270822,
0.0315177,
-0.030154075,
0.030617192,
0.0015718648,
0.018396044,
0.03738385,
-0.019643888,
0.0009149781,
0.020724496,
0.0023091538,
0.022191033,
-0.007261935,
-0.0063582133,
0.02132912,
-0.00033467455,
-0.009172293,
0.007300528,
-0.009365259,
-0.002844633,
0.02530421,
-0.0069596223,
0.0022464402,
-0.0013901556,
-0.024004908,
-0.011996022,
-0.003328655,
-0.00301187,
-0.0024265412,
-0.029588044,
0.016389204,
-0.01635061,
-0.007294096,
0.02601175,
-0.007075402,
-0.019309415,
-0.014549599,
0.022782793,
-0.016736541,
0.032186646,
-0.0048981076,
-0.021869423,
-0.0029539804,
0.02489255,
-0.009455309,
0.012748588,
0.03149197,
0.016775135,
0.03257258,
-0.0058822315,
-0.020968918,
0.019013533,
-0.012748588,
-0.006483641,
-0.0072040455,
0.0015622166,
0.029356485,
-0.01735403,
-0.021432035,
0.012619944,
0.0017447297,
-0.00003701018,
0.009583954,
0.014884072,
-0.017662775,
-0.0040876525,
-0.0085741,
0.0339362,
-0.0055927834,
-0.010233603,
0.0023718677,
0.013288891,
-0.013687686,
-0.024468025,
0.010902551,
-0.015077038,
0.026526324,
0.014601056,
-0.030025432,
0.0130380355,
0.052306514,
-0.0075642476,
-0.00036361936,
-0.025021194,
-0.013996432,
0.010137121,
0.023284504,
-0.019849718,
0.011629388,
0.015064173,
0.006837411,
-0.017624183,
0.017302573,
0.0010701545,
0.015334325,
-0.026230443,
-0.0017913631,
0.0236833,
-0.015861765,
-0.0274011,
-0.000090653586,
-0.023207318,
0.01381633,
0.0009045258,
0.032752678,
-0.014575328,
0.022293948,
-0.0099505875,
0.03007689,
0.0046150917,
-0.008850684,
-0.013842058,
-0.0018492527,
-0.028172964,
0.00350554,
0.0019200067,
0.0004808057,
0.020197056,
-0.0023766917,
-0.020698767,
-0.014678243,
-0.0130380355,
0.022075253,
-0.022576964,
-0.015128495,
0.012478435,
-0.010066367,
0.011475015,
0.012928689,
-0.021367714,
-0.016697949,
-0.010818932,
0.019566702,
-0.0016305585,
-0.0000022440406,
0.0055509745,
-0.00005447255,
-0.021161884,
0.00042733818,
0.011056923,
-0.0020775953,
-0.048987508,
0.0041841352,
-0.011082652,
-0.007332689,
0.041140243,
0.00505248,
0.008123848,
-0.026963713,
-0.025252752,
-0.019077856,
-0.019167908,
0.01820308,
-0.024609534,
-0.024596669,
-0.0061073583,
0.039442148,
0.0011481447,
0.029022012,
0.0068245465,
0.024635263,
0.03656053,
0.021432035,
-0.002633979,
-0.011655116,
0.008889277,
0.023850536,
-0.00652545,
0.013854923,
0.020891732,
0.005042832,
0.018691925,
0.028558895,
0.0015469401,
-0.016376339,
-0.01148788,
0.019232228,
-0.018421773,
0.006033388,
0.009403852,
0.02781276,
0.038670287,
0.012446275,
-0.017379759,
-0.0049656457,
-0.0009961844,
-0.008098119,
0.017379759,
-0.0010492499,
-0.01626056,
-0.022422591,
0.0012518637,
-0.032546848,
-0.004943133,
0.019566702,
0.011288482,
-0.0076607303,
0.017405488,
-0.0007529675,
0.011391397,
0.0058018295,
-0.00933953,
-0.037666865,
-0.001719001,
0.002738502,
0.020364292,
-0.0012285471,
0.021406306,
0.0046504685,
-0.027452558,
0.012529894,
-0.003611671,
-0.010278629,
0.0028655378,
0.028687539,
-0.009873401,
0.0041841352,
0.014845479,
0.016659355,
-0.008085255,
-0.018498959,
0.034244943,
-0.0014995028,
0.0042516734,
-0.0068309787,
-0.008998625,
-0.012472004,
-0.026063208,
-0.001965032,
0.011339939,
0.049527813,
0.0045443377,
0.01204748,
-0.01254919,
0.0007911586,
-0.008812091,
0.028095778,
0.0010926671,
-0.012105369,
-0.013327484,
-0.014716836,
0.016865185,
-0.014896937,
-0.0059722825,
0.011500744,
-0.009982749,
0.010587374,
0.00062673585,
-0.007506358,
-0.024763906,
0.006033388,
0.01148788,
-0.021213342,
-0.029999703,
-0.03313861,
0.0063678618,
0.00294594,
-0.020904597,
-0.0067151994,
0.022679878,
0.0013925678,
0.008156009,
0.006071981,
-0.0035119723,
-0.031028854,
-0.0019264389,
-0.0031855388,
0.017456945,
0.025857378,
-0.011481447,
-0.006274595,
-0.0031372975,
0.0021097562,
-0.012497732,
-0.010130689,
-0.024995465,
0.0063549974,
0.019257957,
0.0026741803,
0.015797442,
-0.0092494795,
0.014716836,
0.010497323,
-0.03923632,
-0.020724496,
-0.0149612585,
-0.008934303,
0.03128614,
-0.014266583,
0.032649763,
0.026577782,
-0.025780192,
-0.02680934,
-0.029150655,
-0.016710812,
-0.015257139,
0.052126415,
-0.0047212224,
-0.020968918,
0.008644855,
0.037203748,
0.02662924,
-0.01319884,
-0.0316978,
0.008258924,
-0.01314095,
-0.018833432,
0.012890096,
0.0068181143,
0.0171482,
0.031594884,
0.01142999,
-0.0031501618,
-0.020660173,
0.011114813,
0.030694379,
-0.0055606226,
0.012761452,
0.034991078,
0.04451071,
0.0292793,
-0.005727859,
-0.012909392,
0.027838489,
0.009776919,
-0.00009341742,
-0.013649093,
0.02224249,
-0.0065093697,
0.0292793,
-0.0015469401,
0.0047276546,
-0.025574362,
-0.01284507,
0.012369089,
0.0064257514,
0.012086073,
0.007905154,
0.006126655,
0.007152588,
-0.004280618,
-0.013880651,
-0.005322632,
-0.013996432,
-0.0025149838,
-0.020312835,
0.023734758,
-0.011005466,
-0.0097704865,
-0.03331871,
-0.005058912,
0.005618512,
0.011192,
-0.007680027,
-0.02059585,
-0.017251115,
-0.002839809,
-0.02082741,
0.018344587,
-0.0015091511,
-0.013185976,
-0.011584362,
-0.007898721,
0.002762623,
-0.006908165,
-0.038027067,
0.004595795,
-0.01847323,
-0.0027819194,
-0.011044059,
0.022808522,
0.022538371,
0.016106186,
-0.010574509,
0.023734758,
0.0037242342,
-0.016607897,
-0.0080466615,
0.0011384964,
-0.026989441,
-0.009217319,
0.023837673,
0.0038367973,
-0.02356752,
-0.009944156,
-0.009159429,
0.016582169,
0.0016787999,
0.018949213,
0.020981783,
-0.017714234,
0.007506358,
0.0203257,
0.015990408,
-0.021573544,
-0.017109608,
0.0068567074,
-0.013340348,
-0.018280266,
0.0027175974,
0.015064173,
-0.012053912,
0.0013057332,
-0.01575885,
-0.022409728,
-0.026204715,
0.02306581,
-0.020235648,
0.0087477695,
0.003502324,
0.023670435,
0.018460367,
0.013089493,
0.009892698,
0.02548431,
-0.001474578,
0.0068695717,
-0.00067417324,
0.006625149,
0.006104142,
-0.01493553,
0.02217817,
0.02150922,
-0.0155015625,
-0.03257258,
-0.035685755,
0.018601874,
0.034064844,
-0.01087039,
-0.018177351,
-0.053567223,
-0.0025551848,
-0.016595034,
-0.011179135,
0.005190772,
-0.02132912,
-0.008619126,
-0.003013478,
-0.0038786067,
-0.03007689,
0.020621581,
-0.032212373,
0.00274011,
0.021419171,
-0.0030279504,
-0.007975907,
0.0032112675,
-0.008992192,
0.007036809,
0.0036020228,
-0.027066628,
-0.02215244,
-0.018022979,
0.0018203079,
0.00980908,
-0.00483057,
0.022628421,
-0.03270122,
0.01861474,
0.014999852,
-0.012478435,
0.028970554,
-0.015540156,
0.018987805,
-0.024468025,
-0.0034798111,
0.01314095,
0.0006347761,
-0.012150395,
-0.011172703,
0.024969736,
-0.00919159,
-0.005792181,
-0.021599272,
0.0033383032,
-0.04003391,
-0.009114404,
0.025458582,
-0.028507438,
0.03596877,
-0.045771416,
-0.0045057447,
0.02336169,
-0.015102766,
0.0068695717,
-0.0115136085,
0.017109608,
-0.0013145775,
-0.013687686,
-0.02345174,
-0.007326257,
-0.026024614,
0.0063871583,
-0.020402886,
-0.010876822,
0.016582169,
-0.004627956,
0.029922517,
0.025201295,
0.009371691,
0.0034540824,
0.02397918,
0.015295732,
-0.028687539,
-0.008535507,
-0.014562463,
-0.018280266,
-0.02907347,
-0.0076028407,
-0.02642341,
-0.002069555,
-0.0023236263,
-0.004872379,
0.020750225,
-0.033704642,
-0.008490482,
-0.0007344749,
0.00073769107,
0.018833432,
-0.012240445,
0.036663447,
0.040934414,
-0.0022576964,
-0.042195123,
-0.010587374,
-0.007834399,
-0.016569305,
0.030745836,
-0.008110983,
-0.021136155,
-0.023863401,
0.027915675,
0.0011915619,
0.004480016,
-0.0045346892,
0.03208373,
0.025587225,
-0.022538371,
-0.0017559861,
-0.01402216,
0.021869423,
0.028764725,
-0.015913222,
0.011449287,
0.0022191033,
-0.021419171,
-0.006557611,
0.027298186,
-0.026860798,
0.036045957,
-0.0073519857,
0.0030440309,
-0.03797561,
-0.016504982,
0.0004070366,
-0.0171482,
0.003749963,
0.018717654,
-0.016440662,
-0.003611671,
0.006055901,
0.010638831,
-0.013147383,
0.013070197,
-0.011397829,
0.034270674,
-0.02560009,
0.0031003123,
0.01858901,
0.010188579,
0.0043385075,
0.010831797,
-0.0030392066,
-0.0411917,
0.0047951927,
-0.005435195,
0.020557258,
0.018344587,
-0.0073519857,
0.0021290528,
-0.019348009,
-0.0049527814,
-0.03185217,
-0.02041575,
0.01281291,
-0.017109608,
-0.0047212224,
0.0058082617,
-0.013829194,
0.019052127,
0.026474867,
-0.01254919,
-0.01755986,
0.015630206,
-0.007815103,
0.0052100685,
0.011108381,
0.023027217,
-0.025947427,
-0.002661316,
-0.02183083,
-0.0292793,
0.002240008,
0.0074549005,
-0.011777327,
-0.031337596,
0.006428967,
0.009596818,
-0.013366077,
-0.023721892,
0.036071684,
-0.023464605,
0.008271788,
-0.025046922,
-0.027581202,
0.06015378,
-0.006702335,
0.0016160861,
0.00484665,
0.015012716,
0.011931701,
-0.020441478,
0.009513199,
-0.028404523,
-0.021843694,
-0.017752826,
-0.039081946,
0.022988623,
-0.009944156,
-0.0030279504,
-0.035093993,
-0.007261935,
0.008239627,
0.0135590425,
0.0063871583,
0.012163259,
0.014948394,
-0.0042966986,
-0.018563282,
-0.0014890505,
0.020055547,
-0.0046858457,
0.018151622,
-0.006110574,
-0.035814397,
-0.0033383032,
-0.02041575,
0.036714904,
0.016775135,
0.03046282,
-0.015990408,
-0.000876385,
-0.06154313,
-0.015270003,
0.0085676685,
0.014871208,
0.005361225,
0.032366745,
0.018344587,
0.0016072418,
-0.0142794475,
0.020557258,
-0.017379759,
0.004943133,
0.0018894539,
-0.018396044,
0.0031051366,
0.01909072,
-0.0155015625,
0.0031131767,
0.018537553,
-0.000088191264,
-0.029973974,
0.010735314,
-0.0041423263,
0.006592988,
-0.02215244,
0.009564657,
-0.008805659,
0.004637604,
0.006068765,
-0.014922665,
-0.004074788,
-0.014498142,
0.012722859,
-0.014922665,
-0.01858901,
-0.0018154838,
0.010227172,
0.020775953,
-0.006876004,
-0.026371952,
-0.000081055565,
-0.01319884,
0.0066058524,
0.0024088528,
0.0041584065,
0.01178376,
0.008824956,
0.0044928803,
-0.011635819,
-0.00016995035,
-0.027118085,
0.028147236,
0.0024249332,
0.015321461,
-0.010278629,
-0.011153406,
-0.00026030242,
-0.016865185,
-0.006499721,
-0.001574277,
-0.020467207,
-0.024532348,
0.03679209,
0.01708388,
-0.029485129,
-0.00042211203,
0.008053093,
-0.033061422,
-0.014266583,
-0.001016285,
0.002981317,
-0.02183083,
0.005293687,
0.0096933,
0.00848405,
-0.0062938915,
-0.0017994033,
0.008477618,
-0.0341163,
-0.014112211,
0.19286259,
0.0035216205,
0.019129314,
0.026937984,
-0.0041905674,
0.018113028,
0.015694527,
0.016016137,
-0.0041165976,
0.0023670434,
0.0072426386,
-0.0029057388,
0.016800864,
0.00645148,
0.015578749,
-0.005714995,
-0.03542847,
-0.023824807,
0.0018926699,
-0.0020454344,
0.003188755,
-0.018974941,
-0.010915415,
-0.015977543,
0.032546848,
0.005261526,
-0.037846968,
-0.0020615149,
0.013533314,
-0.0035537814,
-0.010510188,
-0.015270003,
0.001122416,
0.030025432,
-0.016337747,
0.0025664412,
0.023168724,
-0.013777737,
0.010600238,
0.02336169,
0.011121245,
-0.0017768907,
0.0016578953,
-0.0060494686,
-0.0033768963,
0.0151413595,
0.0010476419,
-0.020968918,
-0.013095926,
0.005785749,
-0.03373037,
-0.009699733,
-0.012864367,
0.021985203,
-0.013185976,
-0.0046954937,
0.043533016,
0.009506767,
-0.0039815214,
0.01861474,
-0.0021113642,
0.010670993,
0.004029763,
0.0069403257,
-0.017752826,
0.024725312,
-0.0262819,
0.0025455365,
0.022885708,
-0.021869423,
-0.006876004,
-0.022885708,
-0.03208373,
0.0114943115,
-0.010478027,
-0.002206239,
0.029922517,
0.010529485,
0.022474049,
-0.0036020228,
0.0030375987,
-0.011198431,
-0.018370315,
0.001963424,
-0.01198959,
-0.042169396,
0.057220705,
-0.003502324,
-0.0274011,
0.004135894,
-0.004663333,
-0.00252624,
-0.005403034,
0.008869981,
0.017778555,
0.01101833,
0.016234832,
-0.013752008,
0.007075402,
-0.03535128,
-0.01906499,
0.065711185,
0.010979737,
0.0149612585,
0.008857117,
0.0095903855,
-0.0092494795,
0.007744349,
0.019077856,
0.000947139,
-0.0023477469,
-0.014446684,
0.013880651,
-0.021805102,
-0.0056635374,
0.00721691,
0.019939769,
-0.024995465,
0.003328655,
0.007815103,
-0.012176123,
-0.035505652,
-0.018228808,
0.036097415,
-0.025162702,
-0.014266583,
-0.003611671,
0.034605145,
-0.001262316,
-0.033087153,
0.01452387,
-0.038747475,
-0.0085741,
0.009037218,
-0.008188169,
-0.007474197,
0.03612314,
-0.012176123,
-0.0027063412,
0.0021322689,
0.008490482,
-0.038155712,
0.055985726,
0.0017029205,
0.00010135714,
-0.0029861412,
0.017855741,
-0.008535507,
0.0075256545,
0.00505248,
0.004441423,
-0.02427506,
-0.011610091,
-0.010806068,
0.030308448,
-0.041088786,
-0.025780192,
0.0003678405,
0.022821387,
0.00094231486,
-0.020158462,
-0.012935121,
0.0024072446,
-0.035274092,
-0.02053153,
-0.00512645,
-0.15992981,
0.0010098527,
0.0061234385,
-0.014189397,
0.016903779,
0.024377976,
0.011822353,
-0.007995204,
0.0025584009,
0.01107622,
0.05145747,
0.014266583,
-0.042426683,
-0.024004908,
0.020840274,
0.0054158983,
-0.019052127,
0.020673038,
0.035093993,
-0.0054673557,
0.047649615,
-0.023914859,
-0.009886266,
-0.040471297,
-0.0014681459,
0.019811125,
0.0011610091,
0.01463965,
-0.0097897835,
-0.014613921,
-0.0067537925,
-0.005255094,
0.042581055,
-0.009300937,
0.0192065,
0.0023011137,
0.017521268,
-0.002598602,
-0.0022030228,
0.007930882,
0.01779142,
0.0044156937,
0.008612693,
0.0031501618,
0.009474606,
0.018254537,
-0.0151413595,
-0.024596669,
0.020544393,
-0.004746951,
0.021419171,
0.0071654525,
0.027452558,
0.027298186,
0.02448089,
0.01310879,
0.014318041,
0.010066367,
0.015270003,
0.008310381,
-0.015720256,
-0.03046282,
0.0063292687,
0.0035698619,
0.008271788,
-0.006991783,
-0.009017921,
0.013366077,
-0.0054834364,
0.020904597,
-0.016929507,
0.006351781,
-0.0013957839,
-0.012915825,
0.028713267,
0.025034059,
0.0037756916,
0.006670174,
-0.017341167,
-0.026500596,
-0.024377976,
0.0155015625,
-0.023966316,
-0.004396397,
-0.009989181,
0.010947576,
0.013957838,
0.0071397237,
0.023233047,
-0.016093323,
0.018756246,
-0.025908835,
0.017855741,
-0.02071163,
0.00245227,
0.008593397,
0.0030247343,
0.002489255,
0.004341724,
0.021393443,
0.0073777144,
-0.005393386,
-0.016106186,
0.009538928,
-0.012311199,
0.004425342,
0.0147297,
0.030771565,
0.027478287,
-0.015295732,
-0.013520449,
0.011423558,
0.005441627,
0.0011851297,
0.009931291,
0.022010932,
-0.012619944,
0.006702335,
0.009024354,
-0.0038142847,
0.0294594,
-0.009185158,
-0.00003394484,
0.022281084,
0.0048595145,
-0.0180873,
-0.13677394,
0.012851503,
0.0053483606,
-0.0033383032,
-0.004763032,
0.027941404,
-0.0074098753,
0.019476652,
-0.02183083,
0.011397829,
-0.025381396,
-0.01635061,
0.0015678448,
-0.020299971,
0.016697949,
-0.021496357,
0.02589597,
-0.008329677,
-0.01788147,
0.034064844,
0.022551235,
-0.013674822,
0.022576964,
-0.012446275,
-0.01582317,
-0.0013411102,
-0.014446684,
0.008831387,
-0.0071718846,
0.0016739757,
0.0011015114,
-0.0015686487,
-0.008812091,
-0.0021724699,
-0.008561236,
0.0046086595,
-0.028764725,
0.005634593,
0.018331723,
-0.030128347,
0.011700141,
0.0072362064,
0.008188169,
-0.01096044,
0.0042195125,
-0.017958656,
-0.030514278,
-0.0032755893,
-0.01596468,
-0.02105897,
-0.014845479,
-0.009255912,
-0.007506358,
-0.013005875,
0.002384732,
-0.029124927,
0.001509955,
0.024377976,
0.000093166156,
-0.0055155973,
-0.0020743792,
0.009892698,
-0.011848082,
-0.0023123699,
0.011192,
-0.017920064,
-0.013777737,
0.012780748,
0.016852321,
-0.04162909,
-0.020197056,
-0.0019039263,
-0.0027513665,
-0.006126655,
-0.019515244,
-0.004357804,
0.016247695,
0.013076629,
-0.0037628273,
-0.00807239,
-0.03007689,
0.0050653443,
-0.003756395,
-0.0033190066,
0.010375112,
0.02904774,
-0.010670993,
-0.003576294,
0.008175305,
-0.010690289,
-0.0066187168,
0.015321461,
0.0019875446,
0.012993011,
0.02020992,
0.0318779,
-0.0077572134,
-0.026963713,
0.008619126,
0.04247814,
-0.0151413595,
-0.029948246,
-0.044382066,
0.005785749,
0.02082741,
0.006207057,
0.013726279,
-0.009468174,
0.012529894,
-0.002598602,
-0.00854194,
0.0039171996,
-0.022268219,
-0.0030086539,
-0.018125894,
0.0036181032,
-0.031620614,
-0.006197409,
0.016620763,
0.019656753,
0.008110983,
0.036689173,
0.00078633445,
0.0038335812,
0.011031195,
0.032649763,
0.0026082504,
0.007326257,
-0.0046569007,
0.030514278,
-0.015951814,
-0.011880243,
0.0039043354,
-0.007885857,
0.008516211,
0.007930882,
-0.003195187,
-0.021560678,
0.011024762,
0.015192817,
0.0083682705,
0.050891437,
-0.018396044,
-0.011738734,
0.019721074,
-0.039982453,
-0.014202261,
0.0068309787,
-0.017868606,
0.004910972,
0.0032691571,
-0.026371952,
0.023721892,
0.006946758,
-0.021303391,
0.009468174,
0.00067859533,
-0.0012711602,
0.011436422,
-0.011378532,
-0.0063260524,
-0.013713415,
0.016299153,
0.008207466,
0.018125894,
0.008342542,
-0.0010203051,
-0.023400282,
-0.03735812,
0.011166271,
-0.008818523,
-0.010587374,
0.012002454,
0.010394408,
0.0076735946,
-0.0028478492,
-0.0053515765,
0.0016787999,
-0.013713415,
0.014703971,
-0.012420546,
0.015051309,
0.005946554,
0.0055220295,
-0.027787032,
0.021007512,
0.038515914,
0.0072683673,
0.0028108642,
0.020557258,
-0.0123562245,
0.0025101595,
-0.010535916,
0.013089493,
-0.0035891584,
0.0039815214,
-0.025458582,
0.010182146,
-0.0034637307,
0.0012896528,
0.025252752,
0.027323915,
0.01799725,
0.01452387,
0.007474197,
-0.04098587,
-0.013378941,
-0.0022995055,
-0.0038367973,
-0.022075253,
0.002735286,
0.0046504685,
-0.014343769,
0.012587783,
-0.015488698,
0.0044703675,
-0.002310762,
-0.019219365,
0.005123234,
0.0040136822,
-0.02807005,
0.0205058,
-0.029202113,
0.018048707,
-0.017830012,
-0.014382362,
0.0029571964,
0.007879425,
0.0076607303,
0.0063260524,
0.01422799,
-0.0037081537,
-0.018627603,
0.002248048,
-0.018781975,
-0.02907347,
-0.018318858,
-0.024249332,
0.013012307,
0.025458582,
0.025934564,
0.03980235,
0.008664151,
-0.017804284,
0.00966114,
-0.013854923,
0.02427506,
0.011397829,
0.011642252,
-0.011648684,
-0.0020213136,
0.012279038,
-0.0030745836,
0.010188579,
-0.030642921,
-0.044639353,
0.015565884,
-0.024069231,
-0.009976316,
-0.014562463,
0.026076071,
0.023799079,
0.0042999145,
0.012317631,
0.007287664,
-0.038901847,
0.010484459,
0.020042684,
0.0008132692,
-0.029176384,
-0.031389054,
-0.025471447,
-0.011944565,
-0.023258775,
-0.0042227283,
0.003573078,
0.017186794,
-0.0038786067,
-0.014716836,
0.019952632,
0.007435604,
-0.00602374,
0.008889277,
-0.014240854,
-0.00986697,
0.00052743906,
-0.020081276,
-0.03208373,
-0.007885857,
-0.0067795212
] |
This paper describes the Estimation and Projection Package (EPP) for estimating and projecting HIV prevalence levels in countries with generalised epidemics. The paper gives an overall summary of the software and interface. It describes the process of defining and modelling a national epidemic in terms of locally relevant sub-epidemics and the four epidemiological parameters used to fit a curve to produce the prevalence trends in the epidemic. It also provides an example of using the EPP in a country with a generalised epidemic. The paper discusses the strengths and weaknesses of the software and its envisaged future developments. | [
-0.009103448,
0.008789537,
-0.00868035,
-0.031964432,
0.0076294267,
0.003951197,
-0.0002923732,
0.010556998,
-0.004705268,
0.0034274415,
-0.01044781,
0.012419997,
0.0052716746,
0.0029855762,
-0.017729204,
0.012119734,
0.026914543,
-0.0060939877,
-0.01070713,
0.0053501525,
-0.0074315257,
0.0018595875,
0.01968092,
-0.023365973,
-0.0073428117,
0.028115598,
0.012631547,
-0.027733445,
-0.020185908,
0.011717107,
0.004288994,
-0.020513467,
-0.0066058007,
-0.01678747,
-0.024198523,
-0.021250479,
0.003637285,
-0.019094039,
0.011996899,
-0.005442279,
0.0027450242,
0.009895053,
-0.004452774,
-0.006482966,
0.018056765,
0.009410536,
0.018384326,
-0.0069435975,
-0.011287184,
0.02404839,
0.0022792742,
0.025481466,
-0.025304038,
-0.0072268005,
0.014303469,
0.002900274,
-0.026109291,
-0.026928192,
0.0068787676,
-0.024430543,
0.0073359874,
0.011839942,
-0.045667373,
-0.005602647,
-0.021264127,
-0.0024805875,
-0.011485085,
0.016350722,
0.0067081633,
0.018029468,
0.047387067,
0.03851564,
-0.02331138,
-0.007861448,
0.012522359,
-0.004623378,
-0.018247843,
-0.010427338,
0.0023423978,
0.009260405,
0.016050458,
-0.012099261,
-0.008864602,
0.0087622395,
0.0011456083,
-0.010127075,
-0.010297679,
0.013696118,
-0.007752262,
0.012870393,
-0.0038113014,
-0.0027262575,
-0.011532854,
0.015600063,
-0.013866723,
0.012679316,
-0.004657499,
0.050608076,
0.02288828,
-0.027146565,
-0.020281445,
0.019162282,
-0.013532338,
-0.0077590863,
-0.008714471,
0.0031357082,
0.009260405,
-0.0041695703,
0.009649383,
0.005599235,
-0.02090927,
0.024034742,
0.0038488342,
-0.017565425,
0.014453601,
-0.010092954,
0.020977512,
-0.017647315,
0.009547019,
-0.013157008,
0.006568268,
0.008775888,
0.038133487,
-0.009212635,
0.011096108,
0.009615262,
-0.028252082,
-0.026341313,
0.020622654,
-0.016337072,
-0.012884041,
0.00400579,
0.012583777,
0.018220546,
-0.037068915,
0.026627928,
0.0009059091,
0.0026068345,
-0.026627928,
-0.026327664,
0.020472523,
0.021359665,
0.005568526,
-0.028606938,
0.0029872824,
0.04067208,
0.02991718,
0.029453136,
0.00052332884,
0.00011249225,
0.009396888,
-0.004268521,
-0.01065936,
0.0044868947,
-0.001799876,
-0.017756501,
0.0013281549,
-0.00047086802,
-0.019926589,
-0.010809492,
-0.02157804,
-0.009581141,
-0.004841752,
0.016842062,
-0.010768547,
0.030080961,
0.0029975185,
-0.03065419,
0.014262524,
-0.002980458,
-0.0139895575,
0.027979115,
-0.027051026,
-0.0027245516,
0.00984046,
0.008871427,
-0.012692965,
0.034230057,
-0.018438919,
-0.032592256,
0.010256734,
0.037778627,
-0.007254097,
0.013791656,
-0.01727881,
-0.013184304,
0.031691466,
-0.0016565683,
0.0030828207,
0.0006866825,
0.011389547,
0.007199504,
0.013341261,
-0.0016233005,
-0.64245504,
-0.034230057,
0.0040433235,
-0.022710852,
0.0047155046,
0.000044277163,
0.021728171,
0.0057288944,
-0.013566459,
0.052901,
0.0001546102,
0.0042446363,
0.0015013183,
-0.017415293,
-0.015913974,
-0.03709621,
-0.02776074,
-0.022328699,
-0.0077590863,
-0.009267229,
-0.028333971,
0.022697203,
-0.021032104,
0.014535491,
0.0063908393,
0.020731842,
0.01891661,
-0.012201624,
0.01049558,
0.0037703563,
-0.0066706305,
0.050689965,
-0.016719228,
-0.0032568371,
0.038297266,
-0.025986455,
-0.018152304,
0.008734943,
0.025904566,
0.04662276,
-0.019230524,
-0.011601096,
0.004183219,
0.01049558,
0.0016190354,
-0.0008107972,
0.009553844,
-0.0097517455,
0.0053910976,
-0.0050737737,
0.0035724551,
0.0014015147,
-0.031363904,
0.0051181307,
0.003835186,
-0.012549656,
-0.006230471,
-0.014385359,
0.011423668,
-0.030381223,
0.004033087,
-0.017510831,
0.0009946234,
-0.0022622137,
-0.025713488,
-0.0008137828,
-0.0041218014,
0.0031920075,
-0.0041866307,
-0.027883576,
0.001720545,
0.02247883,
-0.020800084,
-0.013177481,
0.024648918,
0.008264075,
0.009396888,
-0.022833686,
-0.025304038,
-0.017128678,
-0.0058585536,
0.00038492607,
-0.029889883,
0.011150701,
-0.0063464823,
0.0045619607,
-0.003872719,
-0.004060384,
0.0025232385,
0.032837927,
0.024908235,
-0.0007468206,
0.0010347154,
-0.013825777,
-0.014262524,
0.019639974,
-0.013245722,
-0.0076498995,
0.007247273,
-0.023188544,
-0.0035724551,
-0.019571733,
0.0239665,
0.00859846,
0.028798016,
0.01626883,
-0.0031237658,
0.007404229,
0.05934302,
0.010843613,
-0.009635734,
-0.014317118,
-0.017906634,
-0.022014786,
-0.00007709184,
-0.04364742,
0.013266195,
-0.007943339,
0.013825777,
-0.0006777258,
0.012085613,
0.0047086803,
0.0380243,
-0.019285116,
-0.007397405,
0.028989092,
-0.00075321825,
-0.015340744,
-0.01065936,
-0.015900327,
0.0020199555,
-0.026709817,
0.021550743,
0.0027313759,
0.02868883,
-0.0027689086,
0.0322374,
-0.022014786,
-0.013907667,
-0.025658896,
-0.014330766,
-0.018002171,
0.013457271,
-0.0028695653,
-0.012972755,
-0.038542937,
0.0039716694,
-0.01734705,
0.0198447,
0.007479295,
-0.014508194,
-0.016487205,
0.0041218014,
0.0068241744,
0.01867094,
-0.006377191,
0.0006359277,
-0.02761061,
-0.00673546,
-0.018657293,
0.01136225,
0.03130931,
-0.016009513,
-0.000027230055,
-0.020322392,
0.012761206,
-0.0036782299,
0.034994368,
0.01727881,
-0.03925265,
0.01587303,
-0.007711317,
-0.009117097,
0.033520345,
-0.002306571,
0.013102415,
0.014194283,
-0.038379155,
-0.0015081426,
-0.025522413,
0.018165952,
0.0008645376,
-0.029152872,
0.0030811147,
0.04239177,
-0.012563305,
0.005896087,
0.003371142,
0.0045892573,
0.0054695755,
-0.0041866307,
0.031991728,
-0.0016471851,
0.0044391253,
0.0004734271,
-0.00043674716,
0.007254097,
0.03843375,
0.001411751,
0.040945046,
0.017251512,
-0.008666702,
-0.0059677404,
-0.0018049941,
0.015436282,
-0.026122939,
0.009185338,
-0.02579538,
0.027255753,
0.002233211,
0.01826149,
-0.025768083,
-0.028115598,
0.007636251,
-0.013566459,
0.016814765,
-0.005288735,
0.0082504265,
-0.027078323,
0.0055651143,
-0.013348085,
-0.005234142,
0.027119268,
-0.00019331607,
-0.014535491,
-0.0060564545,
0.0141396895,
0.04402957,
0.015518173,
-0.023202192,
-0.015763843,
0.014671975,
0.014767514,
0.019530786,
0.019981183,
-0.0044118287,
0.016746523,
-0.011485085,
0.024771752,
0.010427338,
-0.013934964,
0.008127592,
0.014603733,
0.013661997,
0.011812646,
0.0004815308,
0.013812128,
0.017579073,
-0.021960193,
0.032373883,
-0.009731272,
0.014494546,
-0.015777491,
0.00657168,
-0.009819987,
-0.010516052,
-0.004742801,
0.015217909,
0.04940702,
0.040808562,
0.005449103,
-0.009042031,
0.019517139,
-0.0050225924,
0.0017299282,
-0.034748696,
-0.020841029,
-0.02793817,
-0.0268463,
0.0080388775,
0.012140206,
0.0013034173,
-0.0012326165,
0.000054966593,
-0.0011609626,
0.004497131,
0.0023031589,
-0.006428372,
0.021919249,
0.001096986,
-0.03488518,
-0.026327664,
0.023461511,
0.012774854,
0.0017486947,
-0.00009820413,
0.0009681797,
-0.0020250736,
-0.030190147,
-0.0032585433,
0.00011249225,
0.045503594,
-0.005472988,
0.0037089388,
-0.018998502,
0.0011387841,
0.0198447,
-0.0018715299,
-0.01760637,
0.008618932,
0.004271933,
-0.012399524,
-0.005309208,
-0.035567597,
0.023174897,
0.007568009,
-0.0064897896,
-0.029535027,
-0.011990074,
0.022437885,
0.02322949,
-0.010782195,
0.02221951,
0.0030367575,
0.0059267953,
-0.0024515847,
-0.01852081,
0.0067593446,
0.03182795,
-0.022178566,
-0.008810009,
-0.042528253,
-0.016623689,
0.0014996124,
0.054402318,
0.008816834,
0.0116761625,
0.016760172,
-0.0053467406,
0.012474591,
0.0012607662,
-0.0148767,
0.013702942,
0.025768083,
-0.017824743,
-0.003014579,
0.011949129,
-0.0031971256,
0.01785204,
0.008373261,
0.0039580213,
-0.0126383705,
0.0016352427,
0.017579073,
0.00068369694,
-0.012460942,
0.02089562,
0.02181006,
0.0072609214,
-0.0011430492,
0.043183375,
0.01463103,
-0.00984046,
0.012467766,
-0.010604767,
0.0014689035,
0.0029258647,
0.021455204,
-0.037560254,
-0.0047189165,
0.009274052,
-0.00044911596,
0.0063567185,
-0.0038590706,
0.019899292,
0.007875097,
-0.00962891,
0.009833635,
0.006646746,
0.0030589362,
0.0025675956,
0.0061315205,
0.0003260676,
-0.009908701,
0.027556015,
-0.0021342605,
-0.013914491,
-0.0014202812,
-0.0021035518,
0.008475624,
0.012433645,
-0.005159076,
-0.006100812,
-0.017961226,
-0.037751332,
-0.018179601,
-0.010959624,
-0.0020131315,
0.0042480486,
0.022519775,
-0.016050458,
-0.00070374296,
-0.011471437,
-0.030545004,
-0.0006064985,
-0.05249155,
-0.0032807218,
0.004026263,
-0.0032977823,
-0.0055105207,
0.00946513,
-0.0067149876,
-0.00061033707,
-0.011471437,
-0.0008769064,
0.008946492,
0.00029749135,
-0.031090938,
0.0051556635,
0.019394303,
-0.0141396895,
-0.021277776,
-0.016255183,
0.0003469666,
-0.0039239004,
-0.003794241,
0.013948612,
-0.009274052,
-0.033247378,
0.017620018,
-0.0031630048,
0.03297441,
-0.016678281,
-0.017565425,
0.0008180479,
-0.03106364,
-0.008434679,
-0.02380272,
0.016732875,
0.020295095,
-0.017306106,
-0.0025505351,
-0.03810619,
-0.03586786,
0.0029906945,
-0.04356553,
0.010618416,
0.033711422,
0.028415862,
0.020881973,
0.0147129195,
0.0053808615,
0.026996434,
-0.021427907,
-0.011669338,
0.01811136,
0.008687174,
0.017483534,
-0.038379155,
0.020936567,
0.0029446313,
-0.010379569,
-0.019899292,
-0.012351755,
-0.008195833,
0.03559489,
0.0007515122,
-0.000024857589,
-0.026559686,
0.003408675,
-0.031554982,
0.0018954144,
0.0045107794,
-0.021782765,
0.0064317845,
-0.024321357,
-0.004104741,
0.007329163,
0.0235434,
-0.024594324,
0.008195833,
0.008168536,
-0.03253766,
0.005039653,
0.0055855867,
0.009785866,
0.0068309987,
-0.006889004,
-0.022437885,
-0.028552346,
-0.0017179858,
0.0061656414,
0.013436799,
0.021919249,
0.028716125,
0.021769116,
-0.0012326165,
0.011082459,
-0.01495859,
0.0014245464,
0.0040433235,
-0.009294526,
-0.0127885025,
0.013334436,
0.013348085,
-0.0019500079,
0.0005553172,
-0.00627824,
0.020404281,
-0.0031783592,
-0.0052750865,
-0.023270434,
-0.011314481,
-0.024539731,
-0.013621052,
0.013818953,
-0.020772787,
0.026805356,
-0.048369747,
0.00049091404,
0.016077755,
0.005681125,
0.012481415,
-0.0035212738,
0.009274052,
0.010284031,
0.023325028,
0.016596392,
0.008980613,
-0.016432611,
-0.002431112,
-0.029371247,
-0.00074468803,
0.038734015,
-0.0054593394,
0.03843375,
-0.02082738,
-0.004930466,
-0.002930983,
0.011587448,
0.0034717987,
0.0072609214,
0.028989092,
-0.0002757393,
0.005486636,
-0.009294526,
-0.014221579,
0.0016650985,
-0.0013998088,
-0.0044903066,
-0.007001603,
0.00400579,
-0.020881973,
-0.01520426,
0.0097517455,
0.00012304839,
0.011396371,
0.001645479,
0.045148738,
0.023980148,
-0.023925556,
-0.02157804,
-0.003565631,
-0.0069879545,
0.029480433,
0.008543866,
0.0037840046,
0.004036499,
-0.02529039,
0.021632632,
0.016200589,
-0.00390684,
-0.027583312,
0.052273177,
0.015217909,
-0.0043504112,
-0.027801687,
0.010434163,
-0.008939669,
0.013232074,
0.0073769325,
0.0035144498,
0.009267229,
-0.020185908,
-0.01933971,
0.027010081,
-0.019558083,
0.03163687,
-0.011853591,
-0.019407952,
-0.01602316,
-0.041763946,
-0.0022212688,
0.0017341933,
0.014166986,
-0.004971411,
-0.0068446468,
-0.016296128,
0.019326061,
-0.005138603,
0.025222149,
0.0056128833,
-0.0013230368,
0.036495686,
-0.007718141,
-0.018397974,
0.013969085,
-0.015722897,
0.027228456,
0.0033370212,
-0.011532854,
-0.036304608,
0.004851988,
-0.005711834,
0.018875666,
0.0067149876,
-0.02918017,
-0.008612108,
0.001333273,
-0.00022285194,
-0.025604302,
-0.0065204985,
-0.0036884663,
-0.018998502,
-0.010529701,
-0.005599235,
0.011123404,
0.03431195,
0.025003774,
0.00067900534,
0.004865636,
0.001997777,
-0.020595359,
0.0076294267,
0.031090938,
0.00020707103,
-0.017524479,
-0.007786383,
-0.041054234,
-0.008523393,
0.008502921,
-0.015559117,
-0.032019027,
-0.03207362,
-0.016978545,
0.029398544,
-0.0075338883,
-0.01652815,
0.000977563,
0.0108640855,
-0.0041422737,
-0.021100346,
-0.019639974,
0.033738717,
0.011778525,
-0.0051522516,
0.022028435,
-0.009683504,
0.03212821,
-0.030135553,
-0.0024106395,
0.014740217,
-0.038379155,
-0.026068347,
-0.022137621,
0.009881404,
-0.022096677,
-0.0013767772,
0.0020609007,
-0.019053094,
-0.0071926797,
0.010550173,
0.0061690537,
0.019476194,
0.003055524,
-0.015982216,
-0.014781161,
-0.0022349171,
0.004742801,
-0.02363894,
-0.0007280541,
-0.004995296,
-0.014057799,
-0.008612108,
-0.017306106,
0.04179124,
0.03272874,
-0.029398544,
-0.027446829,
-0.013675645,
-0.057978183,
0.009492426,
-0.01628248,
0.014849403,
0.0011908184,
0.015722897,
0.022874633,
0.0054968726,
0.012058316,
0.0064556687,
-0.025017424,
-0.033356562,
-0.01003836,
-0.025399577,
0.005865378,
-0.004579021,
-0.032510366,
0.01891661,
0.03297441,
0.0063260095,
0.012781679,
0.02329773,
-0.017387995,
-0.029562322,
-0.0001153712,
0.019203227,
0.004408417,
0.005223905,
-0.008687174,
-0.022820039,
0.0006986248,
0.009478778,
0.009035206,
-0.0154635785,
-0.019940237,
0.02221951,
-0.00805935,
0.009028383,
-0.024362301,
-0.021059401,
0.0087008225,
-0.019230524,
0.0021410848,
0.015163315,
0.01777015,
0.021878302,
0.012071964,
0.0055855867,
-0.00962891,
0.0041695703,
-0.021891952,
-0.001878354,
0.02983529,
-0.0020540764,
-0.016869359,
-0.0078887455,
0.00004422385,
0.0073359874,
-0.0136278765,
-0.0055344054,
-0.0061724656,
-0.010161196,
0.014726568,
0.014044151,
-0.02355705,
0.018998502,
0.0090898005,
-0.0014944942,
-0.0050328285,
-0.009622086,
0.03256496,
-0.016241536,
0.0077317893,
-0.018725535,
-0.015995864,
0.00066578353,
0.014835755,
0.011102932,
0.007936515,
0.025658896,
0.19882914,
-0.009328647,
0.028415862,
0.0065887403,
-0.006302125,
0.020144962,
0.021728171,
0.00830502,
0.017742854,
0.018152304,
0.011464613,
0.00047598616,
-0.018206896,
0.00917169,
-0.015449931,
-0.020295095,
-0.047550846,
-0.013457271,
-0.010625239,
0.0116761625,
0.009744921,
0.020554412,
-0.014972239,
-0.01999483,
0.013859898,
-0.004422065,
-0.035676785,
0.010857262,
0.019653622,
-0.012713437,
0.0068685315,
-0.007199504,
0.01322525,
0.009669855,
-0.03611353,
0.0027074912,
0.031773355,
-0.009717625,
0.008475624,
0.003801065,
0.007001603,
0.0037430597,
-0.015327095,
-0.03166417,
-0.009581141,
0.00026955488,
0.0040569715,
-0.011942305,
-0.010427338,
-0.014849403,
-0.027037378,
-0.037751332,
0.01330714,
0.017510831,
-0.016705578,
0.0012223802,
-0.007861448,
-0.0008730678,
-0.009690328,
0.016500853,
-0.007349636,
-0.0037601201,
-0.013286667,
-0.009110273,
-0.042500958,
0.0322374,
-0.0032329527,
-0.02131872,
-0.016637336,
-0.03783322,
0.010741251,
-0.027665203,
0.0008491832,
0.00023159542,
-0.036058936,
-0.022096677,
0.026081994,
0.010741251,
0.031227421,
0.027979115,
-0.019871995,
-0.01012025,
-0.01901215,
0.0028047357,
-0.001410898,
-0.03436654,
0.0330563,
-0.002069431,
-0.048888385,
-0.0033864966,
-0.008339141,
-0.00092552864,
-0.013716591,
-0.013102415,
-0.0007365843,
0.02470351,
-0.0069538336,
-0.0063908393,
-0.0028763895,
0.009929174,
-0.017838392,
0.09324552,
0.020131314,
-0.014399008,
-0.004770098,
0.009178515,
-0.022615314,
0.009328647,
0.015436282,
-0.006418136,
-0.010966448,
-0.037696738,
0.015927622,
-0.03215551,
0.009506075,
0.00917169,
0.014603733,
-0.0112257665,
-0.004026263,
0.012945458,
-0.0011490204,
-0.027228456,
-0.0021291424,
0.0305723,
-0.0022656259,
-0.0038249497,
-0.0014288115,
0.018971205,
-0.012283513,
-0.0042344,
0.009321822,
-0.0064659053,
0.006462493,
0.0076498995,
0.007131262,
-0.01966727,
-0.017060436,
-0.030708784,
-0.0008982319,
0.030626895,
0.021277776,
-0.0053876857,
0.020690896,
0.0022195627,
-0.0007719847,
0.0026836065,
0.0067252237,
0.026000105,
0.01190136,
0.0026716643,
-0.013163832,
-0.025686191,
-0.007568009,
-0.025972808,
0.013191129,
-0.009649383,
-0.00650685,
0.0020984337,
0.013655173,
-0.011560151,
-0.022656258,
0.0055344054,
0.011785349,
-0.005513933,
-0.006616037,
0.0052955593,
-0.17448048,
0.008229954,
0.01041369,
-0.023379622,
0.005752779,
0.00946513,
0.0001768954,
0.017742854,
-0.014699272,
-0.0036987024,
0.024785401,
0.011505558,
-0.03859753,
-0.013621052,
0.0054593394,
0.009390064,
-0.02735129,
0.0289345,
0.021127643,
0.013873546,
0.032210104,
-0.025522413,
0.0036884663,
-0.006711575,
-0.0121265575,
0.0099632945,
-0.015490876,
0.03783322,
-0.008605284,
-0.014098744,
-0.006257768,
0.007568009,
0.04585845,
0.017551776,
-0.021496149,
-0.024075687,
0.013600579,
-0.0022485654,
0.0161187,
0.021932896,
0.042773925,
0.0020813732,
-0.011519206,
0.013873546,
0.00962891,
0.036659464,
0.029535027,
-0.005711834,
0.021550743,
-0.00031753737,
0.011874063,
-0.0058380812,
0.009410536,
-0.0007481001,
0.0020984337,
-0.016623689,
0.00555829,
-0.001175464,
0.01777015,
-0.01835703,
-0.0330563,
-0.03040852,
0.008775888,
0.00074468803,
-0.00034248826,
-0.04785111,
-0.016323425,
0.012911337,
-0.021250479,
0.0032721916,
-0.014030502,
-0.00407062,
-0.015436282,
-0.035977047,
0.030763378,
0.01652815,
-0.016541798,
0.019885644,
-0.00093832397,
-0.014944942,
0.0066330973,
0.012706612,
0.015845733,
-0.0037089388,
0.006889004,
-0.016964898,
-0.007527064,
0.025358632,
0.008489273,
-0.010461459,
0.0038283619,
-0.032100916,
0.01777015,
-0.0022519776,
0.009042031,
0.010870909,
-0.0046404386,
0.00979269,
0.0029122164,
-0.0017145738,
0.032619555,
0.0040774443,
-0.0037259993,
-0.0016002689,
0.027815334,
-0.01999483,
0.0044493615,
0.008932844,
0.03016285,
-0.0082504265,
-0.032592256,
-0.0012402937,
0.02239694,
0.01049558,
0.00049816474,
0.04812408,
0.00002988242,
0.010611591,
0.004452774,
-0.00047811872,
0.043756604,
-0.010277206,
-0.013853074,
0.0042548724,
-0.010181668,
-0.014890349,
-0.1190136,
-0.008966965,
-0.0044357134,
0.0003749031,
0.0076635475,
0.024021093,
-0.0048690485,
-0.0014962002,
-0.015695602,
0.0058141965,
-0.009076152,
-0.025590654,
-0.0070971414,
0.0085506905,
0.027706148,
0.0046438505,
-0.0052512023,
-0.016746523,
-0.023243139,
0.030763378,
-0.0141396895,
-0.020731842,
0.012986404,
-0.00061161665,
0.015231557,
0.012119734,
-0.0017137207,
0.00040475884,
0.00595068,
0.012631547,
0.01562736,
-0.015354392,
0.010720778,
0.003137414,
-0.007956987,
-0.0019431836,
-0.025658896,
-0.004343587,
0.0051454273,
-0.044930365,
0.0052512023,
-0.011703459,
0.010195317,
0.0013750711,
-0.0024038155,
-0.019708216,
-0.017742854,
0.027405884,
0.0130137,
-0.015545469,
-0.022410588,
-0.02421217,
-0.021018457,
0.004145686,
-0.017046787,
-0.02926206,
-0.012761206,
-0.0009357649,
0.014016854,
-0.0024294062,
-0.0031135294,
-0.0072950423,
-0.0036918784,
0.020158611,
0.009587965,
0.0069197128,
-0.017742854,
-0.007131262,
0.018943908,
-0.0145627875,
-0.02462162,
-0.0076840203,
-0.007165383,
0.002069431,
-0.022628961,
0.010693481,
0.0048349276,
-0.0072950423,
0.019271469,
0.0007643075,
-0.012201624,
-0.014330766,
0.0031851833,
0.002932689,
0.0068446468,
0.026395906,
0.0002953588,
-0.0055105207,
-0.014330766,
-0.0080388775,
0.010734426,
0.01719692,
0.018234193,
-0.013409503,
0.0036270486,
0.0073359874,
-0.024239467,
0.010154371,
0.006452257,
0.009833635,
-0.026627928,
-0.005200021,
-0.06212728,
0.017101381,
0.018848369,
-0.009239932,
-0.008591635,
0.011928657,
0.010147547,
-0.0061690537,
0.019134985,
-0.010632063,
-0.023106653,
0.0032687795,
-0.015681952,
0.003099881,
-0.0421461,
0.007997932,
0.014890349,
-0.0074110534,
0.024416896,
0.037778627,
-0.010741251,
0.015054128,
-0.0013946906,
0.032947112,
-0.0019807166,
-0.003992142,
0.0044493615,
0.015108722,
-0.014439953,
-0.0025675956,
0.0050430647,
-0.013170657,
-0.0076976684,
0.015681952,
0.011389547,
-0.01570925,
0.014399008,
0.022014786,
0.038952388,
0.039962366,
-0.0126383705,
0.0008338288,
0.0054661636,
-0.03106364,
0.0016122112,
-0.016077755,
-0.0101748435,
-0.009738097,
0.014644678,
-0.016719228,
0.048205968,
0.011130229,
-0.026627928,
-0.018875666,
-0.024826346,
-0.0040433235,
0.0037669442,
0.020049425,
0.012112909,
-0.014521843,
0.021100346,
0.008864602,
0.013648349,
0.021673577,
-0.018206896,
-0.010522877,
-0.029862586,
0.011055162,
0.0041729826,
-0.014303469,
-0.0069470094,
-0.011253064,
-0.012508712,
0.020131314,
0.025658896,
-0.011812646,
-0.00094600115,
0.025809027,
0.00053484464,
0.023789072,
0.014399008,
0.016842062,
-0.008837306,
0.032264695,
0.033411156,
0.006694515,
-0.012658844,
0.017715557,
-0.029152872,
0.0148630515,
0.006145169,
0.02048617,
-0.014426304,
0.023734478,
-0.009867756,
0.014453601,
0.023093006,
0.005831257,
0.044657398,
0.04091775,
-0.010420514,
0.01495859,
0.004343587,
-0.036987025,
-0.009390064,
0.007970636,
-0.023666237,
-0.014344415,
-0.004619966,
0.02620483,
0.015968569,
-0.007404229,
-0.0064317845,
-0.0048281034,
0.0056606526,
0.010079306,
-0.010768547,
-0.00047300057,
-0.032865223,
0.0066808667,
-0.006916301,
-0.012365404,
-0.0020063072,
-0.0008376674,
0.028661532,
0.00049048755,
0.007677196,
0.013443624,
0.020936567,
-0.006841235,
-0.008161712,
-0.0029292768,
-0.000068561625,
-0.022110324,
-0.020458875,
0.0037123507,
0.00020237942,
0.0007101406,
0.0035110377,
0.05852412,
0.011512382,
-0.017428942,
0.005745955,
-0.0025539473,
0.024198523,
0.017224217,
-0.0062168227,
0.00062099984,
-0.02313395,
0.0077727344,
-0.006796878,
-0.0009656207,
-0.040617485,
-0.005428631,
0.011259887,
-0.0002565463,
0.01368247,
-0.045721967,
0.009164866,
0.011717107,
0.0067491084,
0.020172259,
-0.00089055474,
-0.036905136,
-0.0014569613,
0.02594551,
0.008612108,
0.014262524,
-0.022547072,
-0.008987438,
0.014358062,
-0.010591119,
-0.023475159,
0.004817867,
-0.00067303417,
-0.014849403,
-0.045994934,
0.021537093,
-0.001958538,
0.002031898,
-0.002654604,
-0.01078902,
-0.025304038,
-0.021468852,
-0.02735129,
-0.011485085,
-0.018643644,
-0.025276741
] |
BACKGROUND Interleukin-24 (IL-24) is a cytokine that belongs to the IL-10 family. It can selectively induce cancer cell apoptosis which has been utilized as a cancer gene therapy strategy. METHODS A recombinant type five adenovirus containing IL-24 gene (designated CNHK600-IL24) was constructed, whose replication is activated only in tumor cells. The replication of CNHK600-IL24 in breast tumor cells and fibroblasts were assessed by TCID50 and MTT assay; the secretion of IL-24 was measured by ELISA and western blotting. The in vivo | [
-0.034090735,
0.0070043122,
-0.025785904,
-0.0229076,
-0.008925382,
-0.006670931,
-0.02511254,
-0.008080375,
-0.018708974,
0.00076991325,
0.017375449,
0.00044808455,
0.0047135525,
-0.0018236958,
-0.021877749,
0.0050337305,
0.024558004,
-0.021587277,
-0.010423948,
-0.012160173,
-0.046290517,
0.010067461,
0.009955234,
-0.015883483,
0.010437151,
0.0076974817,
0.004739959,
-0.049961016,
-0.004102903,
-0.011559426,
-0.008067172,
0.0113349715,
-0.0077238884,
0.0066742315,
0.014695193,
-0.006192314,
0.0050238282,
-0.02053102,
0.01869577,
-0.011717864,
0.029311165,
0.009651559,
0.0031671242,
-0.0024343452,
-0.00621872,
0.006089989,
0.008786748,
-0.03316651,
-0.0024558003,
0.008661318,
-0.006119696,
-0.00022301078,
-0.015183712,
0.010166486,
-0.008892374,
-0.0041986266,
0.023924248,
-0.004601325,
0.008582098,
-0.018444909,
-0.023739403,
-0.021613684,
-0.023382917,
0.013421081,
-0.0026588,
0.014721599,
-0.026525285,
0.017692326,
0.010569184,
0.015144102,
0.03741795,
0.03791967,
-0.01672849,
-0.008892374,
0.007578653,
-0.019078664,
-0.008522684,
0.014404722,
-0.0025053124,
-0.0037002047,
0.025138946,
-0.017362244,
-0.0029047101,
0.009625153,
0.03129165,
-0.00015482848,
-0.019884061,
0.013665341,
0.010074063,
-0.02012172,
0.023079243,
0.0029344175,
0.017388651,
0.028413346,
-0.02838694,
0.031001179,
0.005185568,
0.03121243,
-0.012206384,
-0.042012673,
0.0006127123,
0.005660884,
-0.006806264,
-0.007202361,
-0.03137087,
-0.0021603783,
0.008793349,
-0.00752584,
0.046264112,
0.0024194915,
-0.037233103,
0.030129766,
-0.003921359,
-0.043834716,
0.03889671,
-0.019382339,
-0.0049380073,
-0.014035031,
-0.019910468,
0.0025944342,
0.009110227,
0.030499456,
0.022841584,
-0.010278713,
0.018959835,
0.017269822,
0.010351331,
-0.0335362,
-0.0323215,
0.012424237,
0.015289338,
0.0025218166,
0.026855366,
0.013718153,
-0.01657005,
0.0061791106,
0.009671364,
-0.016926538,
-0.009473316,
-0.021019539,
0.009677966,
0.032506347,
0.0017543789,
0.010701216,
-0.025653873,
0.0065785083,
0.010278713,
0.0008412932,
0.0018352487,
0.0047630644,
-0.019686013,
-0.041035634,
0.010846452,
0.0016792855,
-0.0093346825,
-0.0008305656,
-0.016121142,
0.026908178,
-0.024188314,
-0.015777858,
-0.009057415,
-0.020266956,
0.019619998,
0.018603347,
0.018959835,
0.024201516,
-0.0016454522,
0.016952945,
-0.016860522,
0.001460607,
-0.013823779,
0.014180267,
-0.027225057,
0.028703818,
-0.006839272,
0.020689458,
0.005215275,
0.022524707,
-0.007459824,
-0.024690036,
0.011341573,
0.03174056,
0.012991976,
-0.0048686904,
-0.02920554,
0.0038520417,
0.03279682,
-0.006977906,
0.0030169375,
-0.011651848,
-0.0012798879,
0.02097993,
0.0065620043,
-0.023409324,
-0.6261499,
-0.039820936,
0.008397253,
0.01255627,
-0.00041115677,
0.047505215,
-0.004611227,
-0.03137087,
-0.020161329,
0.025138946,
-0.002597735,
0.005076641,
0.030050546,
-0.012219587,
-0.02257752,
-0.046369735,
-0.015394963,
-0.018603347,
0.013638934,
-0.0040632933,
-0.031186024,
-0.0062649315,
-0.0129391635,
0.012675099,
-0.00043983254,
0.02458441,
0.030235391,
-0.01206775,
-0.0028568485,
0.03242713,
-0.0025663774,
0.04143173,
0.0017246717,
-0.0040104804,
0.048482254,
-0.003358571,
-0.0025630766,
0.019369135,
0.015777858,
0.026115986,
-0.011513215,
-0.02310565,
0.00429435,
0.0058985422,
-0.033060882,
0.005284592,
0.0076644737,
0.009750584,
0.010456957,
-0.012734514,
0.017599903,
0.006690736,
-0.021125164,
-0.0036837007,
-0.015936296,
-0.0077238884,
0.021191182,
-0.03121243,
0.022194626,
-0.0064167688,
-0.0025993856,
0.021864545,
-0.015659029,
-0.018590145,
-0.0012155222,
0.002506963,
-0.014101047,
-0.00024714792,
0.001525798,
0.012853342,
0.017362244,
0.051756654,
0.014814022,
-0.00067707803,
0.018075218,
0.039952967,
-0.012054547,
0.005459535,
0.0091564385,
0.015328947,
0.0057335016,
-0.03247994,
-0.033694636,
0.008113383,
0.0032810022,
-0.004594723,
-0.019382339,
0.011229346,
0.0106550045,
0.016385205,
0.028994288,
0.0030416937,
-0.025799107,
-0.028175687,
-0.029760076,
0.014708396,
-0.010377737,
0.012100758,
-0.00711654,
-0.014074641,
0.004548512,
0.0055519575,
0.001992037,
-0.011572629,
0.008852764,
-0.012978773,
-0.045788795,
0.0037893264,
0.03644091,
-0.023686592,
0.004287748,
-0.0022280447,
0.0059876638,
0.00019278776,
-0.008892374,
-0.013104204,
0.0015695337,
0.022366269,
0.003964269,
-0.01951437,
0.016754895,
-0.0038355377,
-0.00048439341,
0.029416792,
0.021706106,
-0.001623997,
-0.011315166,
-0.017481074,
-0.0100476565,
-0.0020844596,
0.0052779904,
0.002794133,
0.01026551,
-0.0069382964,
0.0058028186,
-0.00543973,
0.026102781,
0.0018451511,
0.0019078664,
-0.022656739,
-0.027753185,
-0.008119985,
0.021574074,
0.0070241173,
0.0010166486,
0.004383472,
-0.010727623,
-0.0019095169,
0.0041491142,
0.0045056017,
0.01693974,
-0.0229076,
0.008357643,
0.018141234,
0.027805997,
-0.015117696,
0.016662473,
-0.03010336,
-0.0098166,
-0.015975906,
0.0007987953,
0.022669943,
0.010219298,
-0.0015645825,
-0.014523551,
-0.0062649315,
0.013704951,
0.028281314,
0.003096157,
-0.04544551,
-0.024901288,
-0.005763209,
-0.03203103,
0.016332394,
0.007202361,
-0.0068854834,
-0.0054298276,
-0.036176845,
-0.018682567,
0.0052614864,
0.004627731,
0.005466136,
0.0022610528,
-0.024280736,
-0.00022775568,
0.017362244,
0.014101047,
0.014681989,
0.003120913,
0.021600481,
-0.0282285,
0.0107606305,
-0.016847318,
0.051281337,
0.023184868,
0.003317311,
0.0043339594,
0.004291049,
0.020214142,
0.0065917117,
-0.0012345018,
-0.022683145,
0.01754709,
-0.0107606305,
0.014668786,
-0.02645927,
-0.003403132,
-0.0014614323,
0.018946633,
0.0010298517,
0.0021983373,
0.012470448,
-0.015804265,
0.012179978,
0.0034295383,
0.005004023,
-0.003129165,
-0.0039081555,
0.01672849,
-0.023580965,
-0.009684567,
0.0010628599,
0.00048810683,
-0.018339284,
-0.0053308033,
0.004891796,
0.009466714,
0.01914468,
0.003980773,
-0.021574074,
0.0062913382,
-0.003350319,
0.009103626,
0.0024244427,
0.024148704,
-0.0081794,
0.0077700997,
-0.0049809176,
0.026208408,
-0.0076116608,
-0.0044230814,
-0.0054001203,
0.013506902,
-0.01598911,
0.0033470183,
0.0011082459,
0.0052911937,
0.010892663,
-0.011183134,
0.011922515,
-0.019039055,
0.023712996,
-0.005231779,
0.015698638,
0.0080143595,
-0.0062649315,
0.0005735152,
0.0102259,
0.0519415,
0.011988531,
0.036335282,
-0.0061791106,
0.004891796,
-0.008535887,
-0.008648114,
0.012635489,
0.00045922477,
-0.0077040833,
-0.011915913,
-0.005518949,
-0.026908178,
-0.0042646425,
0.031397276,
-0.032849632,
0.040269844,
0.0068986868,
0.015883483,
0.028703818,
0.013863389,
-0.00015080562,
-0.006377159,
-0.019857654,
0.016081532,
0.01623997,
-0.004706951,
-0.0048257797,
-0.033985108,
0.00053968193,
-0.012325213,
0.003521961,
-0.006601614,
0.03240072,
0.019461557,
0.0075126365,
0.0029938319,
-0.007591856,
0.021204384,
-0.024967303,
0.0070175156,
0.0035120586,
0.007387206,
-0.005449632,
-0.0015026924,
-0.017613105,
0.02854538,
0.013493699,
0.0044890973,
-0.009123431,
-0.010793638,
-0.025653873,
-0.0003356508,
0.0038190337,
0.0005293669,
-0.037153885,
-0.0061494033,
0.0023468737,
0.0000063888665,
0.010384339,
-0.0014515299,
-0.0155798085,
0.0011008191,
-0.023805419,
0.005743404,
-0.004994121,
0.018458113,
0.034196362,
-0.004568317,
0.0006135375,
0.0014672087,
0.018576942,
-0.01992367,
-0.005046934,
-0.0028816045,
-0.022564316,
-0.012945765,
0.006601614,
-0.012978773,
-0.0031720756,
-0.004479195,
0.013678544,
0.010153282,
-0.02401667,
-0.014219876,
-0.0019425249,
-0.002335321,
0.025284182,
0.017731935,
0.024531597,
0.00021352095,
-0.008839561,
0.002556475,
0.042487986,
-0.018761788,
-0.033694636,
0.0042481385,
0.014167064,
0.005132755,
0.01754709,
-0.013064594,
-0.035886373,
-0.009704373,
0.021376027,
0.0070703286,
0.0018451511,
0.027515527,
0.031344462,
0.007928538,
0.008337839,
0.0021636789,
-0.00022528008,
-0.01026551,
0.00515256,
-0.015725045,
-0.022656739,
0.027753185,
-0.028651005,
-0.012694904,
-0.008575496,
0.014840428,
0.002384833,
-0.013850186,
-0.0028271412,
-0.0070505235,
0.0065455004,
-0.011896108,
-0.026274424,
0.016253173,
-0.003931261,
-0.019078664,
-0.016926538,
-0.008502879,
-0.016543645,
-0.0017758341,
-0.017269822,
0.014655583,
-0.02622161,
-0.005449632,
0.0098166,
0.0024607517,
-0.010621997,
0.023897842,
-0.015540199,
0.0014259486,
0.027621152,
-0.013572918,
-0.016543645,
0.0074268156,
-0.044310033,
-0.0072881817,
-0.0027231658,
-0.0055321525,
-0.0026819056,
-0.011915913,
-0.018352486,
-0.0009217503,
-0.0103315255,
0.02183814,
0.012562871,
-0.013704951,
0.04209189,
0.01583067,
0.011427394,
-0.005403421,
-0.0032100347,
0.0078691235,
-0.015923092,
-0.032902446,
-0.010470159,
-0.019210696,
-0.0038091312,
0.024109093,
0.020544223,
-0.020676255,
-0.017494276,
0.01419347,
0.005885339,
-0.0009588844,
0.0119027095,
-0.005502445,
0.023171665,
0.0009539332,
0.0033569208,
-0.002597735,
-0.01497246,
-0.019501168,
-0.02674974,
0.012655294,
-0.0020564029,
-0.023541356,
-0.002733068,
0.010252306,
-0.022458691,
0.0012988675,
-0.0017609805,
-0.012417636,
0.019171087,
-0.01546098,
-0.025429416,
-0.03522621,
0.007387206,
-0.0027759788,
0.016530441,
0.017309431,
-0.03562231,
-0.022392675,
0.0021768822,
-0.0058358265,
0.0008206631,
0.010087267,
-0.030525863,
-0.019897265,
0.007268377,
0.007473027,
0.0007104987,
-0.021534465,
-0.013216431,
-0.0014812371,
-0.0070505235,
-0.015843874,
-0.029839296,
-0.0066082156,
0.007928538,
0.055453558,
0.0037662208,
0.024967303,
-0.009717575,
0.014246283,
-0.010503168,
0.0045749187,
0.012985375,
-0.008898975,
0.009024406,
-0.005964558,
0.021824935,
0.025469027,
-0.01762631,
0.03799889,
-0.018497722,
-0.008674521,
0.023316901,
-0.006977906,
-0.025376605,
0.0073475963,
-0.015857076,
-0.045419104,
0.021402432,
-0.015949499,
-0.008278424,
-0.029601637,
0.0035087578,
0.014959257,
0.022181423,
0.028202094,
0.0022544512,
0.021772122,
-0.021600481,
0.007816311,
-0.005162462,
0.0015802614,
-0.02809647,
0.0029921816,
0.008271823,
0.018444909,
0.051149305,
0.01067481,
0.0033932296,
0.0027512226,
-0.010978484,
-0.00049305806,
0.0073409947,
-0.015302541,
-0.01631919,
-0.028862257,
-0.020702662,
-0.0270006,
-0.0073145884,
-0.011585833,
-0.031766966,
0.0053275023,
0.017850764,
-0.016345596,
0.025336994,
0.012424237,
-0.011486808,
0.034222767,
0.020200938,
0.009605348,
-0.0117970845,
0.047135524,
0.007974749,
0.006189013,
-0.036625754,
-0.017467871,
-0.011031297,
0.0137973735,
0.024122298,
0.051598214,
0.002597735,
0.010767233,
0.008859366,
0.012292205,
-0.0043900735,
-0.019818045,
0.022511503,
-0.014219876,
0.02257752,
-0.044917382,
-0.023897842,
-0.018392097,
0.020795085,
-0.007657872,
0.007882327,
0.0037563182,
-0.02519176,
-0.0039972775,
0.018933428,
-0.0002861387,
0.014444332,
-0.002147175,
-0.009578941,
-0.022696348,
-0.011216142,
-0.019237103,
-0.006357354,
0.010707818,
0.030446643,
-0.0007253523,
-0.0022032887,
-0.00208611,
-0.022894397,
-0.0037926272,
-0.008152993,
-0.008225611,
0.03308729,
-0.011414191,
0.021732513,
-0.009770389,
-0.0045254063,
0.016873725,
-0.015434573,
-0.005231779,
0.013836983,
-0.021257197,
0.0008936935,
0.019316323,
0.023858232,
-0.0044032764,
0.009413902,
-0.020319767,
-0.014470737,
-0.043913934,
-0.015262932,
0.01623997,
-0.034698084,
0.012483652,
-0.016107937,
-0.0008157119,
0.007743693,
0.057935763,
0.0029344175,
-0.006720443,
0.030525863,
-0.029707262,
-0.005921648,
-0.006103192,
0.0072617754,
-0.010595591,
0.000058331447,
0.0044890973,
-0.014404722,
0.017230213,
-0.021138368,
-0.03488293,
-0.018880615,
-0.0237262,
0.0056872903,
0.016041921,
-0.023422526,
0.036704972,
0.013038187,
-0.0022247438,
-0.0021455246,
-0.018471316,
0.0063969637,
-0.027409902,
-0.0068326704,
0.042250328,
0.003403132,
-0.0042316345,
-0.00060033426,
-0.00019856417,
0.00057186483,
-0.0021257198,
-0.026366847,
-0.012820334,
0.005301096,
0.0022313455,
-0.0017774845,
-0.025799107,
-0.004165618,
-0.019540777,
0.014787615,
0.0038058304,
0.0073938076,
-0.0026720033,
0.0089055775,
-0.0036638957,
0.030816333,
-0.017467871,
0.0053407056,
-0.004802674,
-0.028941475,
-0.007624864,
-0.0033998312,
-0.012661896,
0.027383495,
0.0021999879,
0.012325213,
-0.040190626,
-0.012173376,
-0.046132077,
-0.0024937596,
0.0075324415,
0.01865616,
-0.0033602214,
0.019936875,
-0.026551692,
0.003345368,
-0.0110445,
0.0014589566,
-0.003541766,
-0.012675099,
0.016807709,
-0.015936296,
0.026366847,
0.013454089,
-0.009895819,
-0.02078188,
0.02425433,
0.016081532,
-0.011849897,
0.04053391,
-0.016609661,
0.015672231,
-0.008199205,
0.008252017,
-0.034618862,
0.017784748,
0.01378417,
-0.008839561,
0.0054100226,
0.016622864,
0.002785881,
0.009843007,
0.0005627876,
-0.015368558,
0.016451223,
0.012807131,
0.0032694493,
-0.03485652,
-0.016213564,
-0.013863389,
0.012252595,
0.00953273,
0.013348463,
0.012034742,
-0.001030677,
-0.01803561,
-0.028175687,
-0.012252595,
-0.0064200694,
-0.015764654,
0.0090838205,
0.011770678,
-0.0096185515,
0.012127165,
-0.00087388867,
-0.016451223,
-0.013969015,
0.0053671123,
0.002572979,
-0.021560872,
0.011315166,
0.016372003,
-0.008991398,
-0.013209829,
0.017243415,
-0.018431706,
-0.021059148,
0.0052020717,
-0.0059975665,
-0.01623997,
-0.0072947834,
0.0069382964,
-0.012767522,
0.0048818933,
-0.011275557,
-0.020359378,
-0.0068326704,
0.015513793,
0.20016094,
-0.030341018,
0.014246283,
0.017837562,
-0.002675304,
0.02123079,
0.014774412,
0.007948344,
-0.0030169375,
0.009064016,
0.017283026,
-0.007783303,
0.0026455969,
0.0016223466,
0.0012716359,
-0.010443754,
-0.013929405,
0.009849608,
-0.03607122,
-0.0054958435,
-0.0075852545,
0.004017082,
0.03694263,
-0.0062319236,
0.02175892,
0.013308854,
-0.02793803,
0.0099750385,
0.010364534,
0.010417347,
-0.030869147,
0.022339862,
-0.018841006,
0.015593012,
0.0039939764,
0.028571784,
-0.000568564,
-0.019052258,
0.01149341,
-0.0012039694,
-0.002982279,
-0.003729912,
-0.029443199,
0.008060571,
-0.010826647,
0.019567184,
-0.011090712,
-0.021125164,
-0.0029014093,
0.009031008,
-0.029839296,
0.012490254,
0.035675123,
0.020795085,
0.004835682,
0.006479484,
0.01992367,
0.01251666,
0.006977906,
-0.0113349715,
0.007202361,
0.010701216,
-0.031080399,
0.012034742,
-0.014101047,
0.026525285,
-0.017863967,
-0.006060282,
0.01672849,
-0.022683145,
0.006733646,
-0.010278713,
-0.014708396,
-0.0046673412,
-0.0026389952,
-0.010661607,
0.020240549,
0.013480496,
0.021587277,
0.007888929,
0.033113696,
-0.0076908804,
-0.038025297,
0.024241127,
0.004297651,
-0.03657294,
0.007136345,
0.005858932,
-0.03501496,
-0.019501168,
0.00069358206,
-0.009222454,
-0.013460691,
0.0022643537,
0.024280736,
0.000084222156,
0.0011552825,
-0.02115157,
0.01169806,
-0.023039633,
-0.018761788,
0.07135025,
0.008047367,
-0.00079178106,
-0.012232791,
0.013955812,
-0.0077899043,
0.002752873,
0.0038256352,
-0.0093346825,
0.018273268,
-0.041299697,
0.013559715,
-0.01542137,
-0.0078031076,
0.031925406,
0.0008953439,
-0.03754998,
0.009354487,
-0.0298657,
-0.013143813,
-0.03636169,
-0.00028056858,
0.033932295,
-0.013150415,
0.029786482,
-0.0253634,
0.00008071504,
-0.0059447535,
-0.029786482,
0.015777858,
0.02651208,
0.0014028429,
0.019606793,
0.026498878,
0.009559137,
-0.007849319,
-0.012113961,
-0.007248572,
0.0016660823,
-0.012820334,
-0.017943187,
0.0013401277,
0.005657583,
0.0007814661,
-0.0008474822,
0.01374456,
0.02854538,
-0.023079243,
-0.019910468,
-0.0066742315,
-0.024069484,
-0.004020383,
-0.009097024,
0.021072352,
-0.015751451,
-0.026762944,
0.0018286471,
0.0018088422,
0.01795639,
-0.02597075,
0.007915335,
0.0110445,
-0.0045254063,
-0.025350198,
-0.0030647994,
-0.16541004,
0.0036308877,
0.020702662,
-0.016332394,
0.03850061,
0.017903578,
-0.0043009515,
-0.012397831,
0.004426382,
0.0044494877,
0.024808865,
-0.005010625,
-0.03472449,
0.006670931,
-0.0062649315,
0.009123431,
-0.0013937658,
0.037153885,
0.029522417,
0.0022263944,
0.033113696,
-0.021177977,
-0.0036374894,
-0.0053803152,
0.0031027587,
0.0010067461,
0.003815733,
-0.03636169,
-0.0016058426,
-0.012840139,
0.000322035,
0.006892085,
0.0004278671,
-0.020253751,
0.014576363,
-0.007492832,
0.011929116,
0.0029179133,
-0.014101047,
0.008146391,
0.022036187,
0.01292596,
-0.0019887362,
0.016622864,
-0.01832608,
0.02310565,
0.0016066678,
-0.0053242017,
0.01243744,
-0.0066313213,
0.02711943,
-0.032664787,
0.026102781,
0.0077767014,
0.029839296,
0.0044032764,
0.012212986,
-0.008133189,
0.008502879,
0.009928827,
-0.021481652,
-0.014470737,
0.024544802,
-0.0013219732,
0.019303119,
-0.030605081,
-0.020425394,
0.046000045,
-0.0006638748,
0.0094073,
-0.043174554,
-0.012675099,
0.016015515,
-0.025997156,
0.015170509,
0.009519528,
-0.0025020116,
0.020676255,
0.018220454,
0.0085887,
-0.021032741,
0.022815177,
-0.042487986,
-0.0027231658,
-0.003951066,
-0.004568317,
0.016952945,
0.041141257,
-0.007268377,
-0.016517239,
0.007849319,
-0.029179133,
0.00044932234,
-0.009902421,
0.02875663,
0.03145009,
0.003729912,
-0.004000578,
0.003799229,
0.0018781591,
0.01198193,
-0.041405324,
-0.0021240693,
0.009658162,
0.020953523,
-0.022339862,
-0.02875663,
-0.00096631126,
0.03350979,
-0.019897265,
-0.0069184913,
0.0021620286,
-0.0022544512,
0.023950655,
-0.009308276,
0.018497722,
-0.008133189,
-0.0044593904,
0.012094157,
-0.027832404,
0.063797995,
-0.0023369712,
-0.019382339,
0.027515527,
-0.033192914,
-0.033615418,
-0.11270275,
-0.026921382,
0.0429369,
0.01043055,
-0.013289049,
0.02981289,
-0.013407878,
0.031872593,
-0.02302643,
0.026208408,
-0.01873538,
0.00030924435,
-0.0154741835,
0.010258908,
0.017335838,
0.003120913,
0.01598911,
0.00503043,
-0.026366847,
0.03382667,
0.009209251,
-0.015025273,
0.010932272,
-0.020029297,
0.008555692,
-0.0060635824,
-0.031502903,
0.031476494,
0.026327236,
0.0167681,
0.034777302,
-0.0038916515,
0.015328947,
0.0096911695,
-0.024465581,
-0.0004736658,
-0.015698638,
-0.017520683,
0.027251462,
-0.022881193,
-0.008304831,
-0.0007055475,
-0.009103626,
-0.017309431,
0.011077508,
-0.015394963,
-0.019765232,
-0.009400698,
0.017811155,
-0.021534465,
-0.036625754,
-0.023660185,
-0.030235391,
0.002520166,
0.0007195759,
-0.019157883,
0.008417058,
0.007783303,
-0.023184868,
-0.0024079387,
0.015857076,
-0.006819467,
-0.032268688,
0.00015173397,
0.026076375,
-0.0044494877,
0.0040797973,
0.0034097335,
0.029918514,
-0.003505457,
-0.011764076,
0.0032793516,
-0.0042118295,
-0.012358221,
-0.022115408,
-0.008192603,
0.009235658,
-0.007440019,
0.01497246,
-0.008397253,
-0.030261798,
-0.021296807,
0.0066940365,
-0.013704951,
0.012450644,
0.002498711,
-0.01026551,
-0.009644958,
0.0006122997,
-0.005796217,
-0.0017972894,
0.03218947,
0.00478617,
-0.009427105,
-0.004855487,
0.008568895,
-0.0005648506,
0.005779713,
0.032902446,
0.035199806,
-0.020742271,
-0.028070062,
-0.07219525,
0.014576363,
-0.0045716176,
0.0072551738,
0.0031473194,
-0.029680856,
-0.0030235392,
0.0039774724,
0.0136521375,
0.009479918,
-0.0063012405,
0.020332972,
-0.00687228,
0.0141538605,
-0.0062913382,
0.008648114,
0.016372003,
-0.007030719,
0.016121142,
0.009539332,
0.009836405,
-0.011136923,
0.012094157,
-0.005918347,
-0.013091001,
-0.008918781,
0.028862257,
0.037576385,
-0.015038476,
-0.012001734,
-0.0020217444,
-0.029020695,
-0.042012673,
0.004584821,
-0.010853053,
-0.03546387,
-0.018444909,
0.028492566,
0.011130321,
0.014827225,
-0.0046046255,
-0.03546387,
0.03047305,
0.005674087,
0.0323215,
0.02000289,
-0.012457246,
0.021243993,
-0.005419925,
-0.011717864,
0.048455846,
0.012628888,
-0.008311432,
-0.021904156,
-0.013216431,
0.020649849,
-0.00067955366,
-0.02994492,
-0.0056344774,
0.0055123474,
0.008285025,
0.0057368027,
0.005145958,
0.04180142,
0.0009374292,
-0.022102203,
-0.033694636,
-0.0049875192,
0.012397831,
0.0004258041,
0.009044211,
-0.004617829,
0.012100758,
-0.019897265,
0.00875374,
-0.007961546,
-0.031238837,
0.0112623535,
-0.0064167688,
0.009189446,
0.0034064327,
0.00077280146,
-0.007043922,
0.0042745452,
0.027330682,
0.0100476565,
-0.019276712,
0.03277041,
0.01169806,
-0.015183712,
0.0061692083,
-0.0024079387,
-0.000018786233,
-0.0017972894,
-0.006311143,
0.008951789,
-0.012041344,
0.03145009,
-0.007921937,
0.04045469,
0.027515527,
0.0020910613,
0.0041986266,
0.0010587338,
-0.004928105,
0.009387495,
-0.031001179,
-0.046237703,
-0.010754029,
0.0012336766,
0.012774123,
0.016900131,
0.0107606305,
0.018299675,
-0.020016093,
0.001284014,
-0.0069184913,
-0.0060767857,
-0.01762631,
0.053446665,
-0.0032116852,
0.012279002,
0.02384503,
-0.0077172867,
-0.00396757,
0.0068524755,
0.021745717,
-0.006324346,
0.026010359,
-0.01026551,
0.0035318634,
0.023950655,
-0.043913934,
-0.014285892,
-0.013995421,
0.009724177,
0.013104204,
0.0043339594,
-0.0003309059,
0.083338775,
0.011585833,
-0.032849632,
0.017863967,
-0.023739403,
0.017573496,
0.017388651,
0.016345596,
-0.02462402,
-0.030895554,
-0.005010625,
-0.0154741835,
0.034698084,
-0.06490707,
-0.04314815,
-0.00088709185,
0.017045368,
0.0015142452,
-0.0032463437,
-0.01791678,
0.003129165,
0.009427105,
-0.012932561,
0.014549958,
-0.056985132,
0.009400698,
0.028149283,
0.00022734309,
-0.010866256,
-0.024940897,
0.0060668834,
0.00022569268,
-0.026736537,
-0.02920554,
0.021904156,
-0.03501496,
0.0014160462,
-0.029628044,
0.022669943,
0.032849632,
0.00055536075,
0.014259486,
-0.020742271,
-0.008766944,
0.015196916,
-0.007968148,
-0.034169953,
0.0006180761,
-0.015302541
] |
BACKGROUND AND PURPOSE Migraineurs are at increased risk of cerebellar infarcts and supratentorial white matter lesions. The prevalence, frequency, and distribution of infratentorial hyperintense lesions in migraine are unknown. METHODS Migraineurs with aura (n=161), without aura (n=134), and controls (n=140) from a population-based sample of adults (30 to 60 years of age) were evaluated with MRI. RESULTS Infratentorial hyperintensities were identified in 13 of 295 (4.4%) migraineurs and in 1 of 140 ( | [
0.012963251,
0.0069180764,
0.020480633,
-0.030095588,
-0.02230461,
0.0157383,
-0.014526658,
-0.017848898,
0.009569354,
-0.0070418464,
-0.0027685335,
0.029365998,
0.006097288,
0.0053318697,
0.0075694965,
-0.006439283,
0.04020562,
-0.011569213,
0.009921121,
-0.022903915,
-0.0010219145,
0.0062145432,
-0.017692558,
-0.007367556,
-0.010995964,
0.016676342,
0.013640728,
-0.02967868,
-0.0019640303,
-0.029157544,
0.015269277,
-0.0025340223,
0.00875508,
-0.0063220276,
-0.0091785025,
-0.015334418,
0.030173758,
-0.009895065,
-0.0051299296,
-0.0056673507,
-0.010429229,
-0.013497415,
-0.0012971393,
-0.007843093,
0.0013818239,
0.012233661,
0.00066119095,
-0.007426184,
-0.014800254,
0.018357005,
0.013797068,
0.009171989,
-0.016949939,
0.04432259,
-0.0055859233,
-0.028870918,
0.013354103,
0.020194009,
-0.0007279615,
-0.04335849,
0.01758833,
-0.0049963887,
-0.01929505,
0.0041202293,
-0.015152021,
0.017445019,
0.0024786517,
0.008461941,
0.011008992,
-0.011061106,
0.04411414,
0.029339941,
0.009426042,
-0.019751044,
0.027828647,
-0.026161013,
-0.009829923,
-0.022578204,
0.014761169,
0.00027868547,
0.0429937,
-0.008618282,
-0.020806344,
0.017966153,
-0.0021089711,
0.0051787863,
-0.008611768,
0.018656658,
-0.009712667,
0.005898605,
-0.022447921,
-0.008168803,
-0.010272888,
-0.014617857,
0.0088593075,
0.023724703,
0.0020470861,
0.0069701904,
0.0105204275,
-0.004813991,
-0.016324576,
0.005732493,
-0.024141612,
-0.017093252,
-0.013562557,
-0.010859165,
0.0021578276,
0.0066086524,
0.015269277,
-0.03079912,
-0.00125724,
0.009022162,
-0.008240459,
-0.010364086,
-0.014735112,
-0.0074717836,
0.039137293,
0.002737591,
-0.001186398,
-0.023229625,
0.00553381,
-0.010103519,
0.0064816256,
-0.0068789916,
0.02277363,
0.016272463,
-0.022747574,
-0.012891595,
-0.011289102,
-0.024454294,
-0.026838489,
-0.001408695,
0.013914323,
-0.021692274,
0.0038564042,
0.00051950716,
-0.0028076186,
0.005833463,
-0.011178361,
-0.04023168,
0.007302414,
0.01321079,
-0.03048644,
-0.031841394,
-0.01816158,
0.02861035,
0.025079656,
0.03556751,
0.011165333,
-0.019751044,
-0.0209236,
-0.010637683,
0.010637683,
0.0064783683,
0.0011473128,
0.0026822204,
-0.0118102385,
0.04249862,
-0.0107679665,
-0.0032587268,
-0.0052764993,
-0.013217305,
0.0072372723,
0.009901579,
-0.0030421298,
0.009380443,
-0.026968773,
-0.027203284,
0.013744955,
-0.010077462,
0.0032310414,
0.030147702,
-0.02440218,
-0.0031512426,
0.0022587976,
0.018747857,
0.0046250797,
0.01338016,
-0.028923033,
-0.03723515,
-0.020741202,
0.021340508,
0.02651278,
0.0035632655,
0.0035078947,
0.012709198,
0.04231622,
-0.016129151,
-0.017640444,
-0.040075336,
0.001518622,
0.024623662,
-0.009315301,
-0.010937336,
-0.6503774,
-0.009517241,
0.02643461,
-0.019138709,
0.038016852,
0.022278551,
0.005839977,
0.0061135734,
0.010383629,
0.020089783,
-0.017953126,
0.019464418,
-0.005810663,
-0.009549812,
-0.0057552927,
-0.024063442,
-0.02668215,
-0.014200948,
0.018343978,
-0.016832683,
-0.009771295,
0.02448035,
-0.009367415,
0.022760602,
0.011608298,
0.0058627767,
-0.0012678255,
-0.008787651,
-0.013002336,
0.020532748,
-0.03543723,
0.04158663,
-0.014383346,
0.030199815,
0.040388018,
-0.024636691,
-0.015608015,
0.029470224,
0.0011163704,
0.043827515,
-0.005133187,
-0.028323727,
0.048387453,
-0.008110175,
-0.012376973,
0.025639877,
0.0005744707,
-0.015099907,
0.01280691,
-0.02091057,
-0.0067747645,
0.0025698505,
-0.014878425,
0.027854703,
0.00054434256,
-0.025209941,
0.0025617077,
-0.0061852294,
-0.00880068,
0.0035697797,
0.0041202293,
0.01184281,
-0.00068643346,
0.012872052,
-0.0135365,
-0.0042179422,
-0.0093609,
-0.008331657,
0.011653897,
-0.009673581,
0.031841394,
0.0046543935,
-0.0028092472,
0.010846137,
0.020610917,
0.018031295,
0.01735382,
0.00049222895,
-0.0156471,
-0.011569213,
0.0045664515,
-0.006696594,
-0.014057636,
0.0016204064,
0.016402747,
-0.017887983,
-0.015451674,
-0.0069767046,
0.00198683,
-0.010774481,
-0.0013541386,
0.010807052,
0.009849465,
-0.050419882,
-0.017445019,
0.0100253485,
-0.0045371377,
0.012800396,
0.017002054,
-0.006103802,
-0.0094781555,
-0.0050680446,
-0.009139418,
-0.009074275,
0.0011163704,
0.00502896,
-0.024988458,
-0.008279543,
0.0343689,
-0.017874954,
-0.01710628,
0.011373787,
-0.008527083,
0.0023565106,
0.018357005,
-0.025913473,
-0.010325002,
0.00530907,
-0.027594136,
-0.005696665,
0.026786376,
0.027099058,
0.019138709,
-0.016741484,
0.0059246616,
-0.0019119167,
0.00709396,
-0.0016570487,
-0.0043710256,
-0.014800254,
-0.00046291508,
0.005976775,
0.024701834,
0.0006127416,
0.0291836,
0.0015577072,
0.01524322,
-0.014461516,
-0.004807477,
-0.036661897,
-0.044140194,
-0.012396516,
0.01816158,
0.013171705,
-0.023972243,
-0.026617007,
-0.012911137,
-0.003543723,
-0.014891453,
-0.010064433,
-0.001776747,
-0.016090065,
-0.017953126,
0.009673581,
0.019894356,
0.00067421934,
-0.0022799687,
-0.029574452,
-0.005739007,
-0.027281456,
0.0023679105,
0.0058464915,
-0.0038564042,
0.005071302,
-0.019490477,
-0.026369467,
-0.012572399,
0.014578772,
0.008885364,
-0.03186745,
-0.0025095942,
0.0036088647,
0.005823692,
0.028532181,
-0.00034484526,
0.028766692,
0.00088755926,
-0.02018098,
-0.02528811,
-0.004533881,
0.0069832187,
0.005706436,
-0.0048856474,
-0.0062764282,
0.020128867,
0.012324859,
0.009979749,
-0.0027294483,
-0.0053123273,
0.013165191,
0.0077518937,
0.026643064,
-0.008839765,
-0.0094065,
0.00081346027,
0.012435601,
0.0047521065,
0.0024851658,
-0.021522906,
0.019086596,
0.034994263,
0.002257169,
0.006598881,
0.010136089,
0.04385357,
-0.01864363,
0.00033202046,
-0.024923315,
0.019086596,
-0.01678057,
0.00006203754,
0.00061111304,
-0.0076541808,
-0.019321106,
-0.02368562,
0.004146286,
0.027125115,
0.0046967356,
-0.008305601,
-0.006931105,
-0.0032994405,
0.006256886,
0.024389151,
0.0036642356,
-0.0012360688,
0.019399278,
0.007321957,
0.003934575,
0.01685874,
-0.015125964,
-0.008579196,
0.024584578,
0.0047814203,
0.019920412,
0.008344686,
0.0065597957,
0.00080287474,
-0.010513913,
0.008292572,
0.014617857,
0.025639877,
0.028401896,
-0.01154967,
-0.025874387,
0.026447637,
-0.019177794,
0.009250159,
-0.004797706,
0.0060093463,
0.03113786,
0.004214685,
0.0033776108,
-0.00440034,
0.006067974,
0.0022978827,
-0.008338171,
0.014891453,
0.005009417,
0.01195355,
0.019842243,
0.03517666,
-0.011660412,
0.0150608225,
-0.012748282,
0.000029288438,
0.00500616,
0.008644339,
0.0031219285,
0.0011920979,
-0.0037749768,
-0.028870918,
0.00015033544,
-0.008487998,
-0.030199815,
0.015112936,
-0.0018435176,
-0.009289244,
0.021366565,
0.038068965,
0.041534517,
-0.018096438,
-0.05649111,
0.009302272,
0.0056184945,
-0.00634157,
-0.011399844,
0.0111913895,
0.0006115202,
-0.010911279,
-0.0119340075,
0.003250584,
0.027698364,
-0.028870918,
-0.01929505,
0.0010789138,
0.0028955603,
0.031268142,
0.013901295,
-0.0009413014,
-0.011881894,
-0.0083512,
-0.00084684556,
-0.021340508,
0.0060516885,
-0.007484812,
0.013888267,
-0.025522621,
0.0075108684,
-0.000110537774,
0.00437754,
0.012025206,
-0.002947674,
0.00010035934,
0.030277986,
-0.00583672,
0.0086834235,
-0.0058432342,
-0.0019200594,
0.031606883,
-0.002770162,
-0.009022162,
-0.0512537,
-0.0069767046,
-0.02365956,
0.020962683,
0.029652622,
-0.016741484,
0.030694894,
0.02147079,
-0.0068138493,
-0.002633364,
-0.022017984,
0.00786915,
0.0006029703,
0.012285775,
0.004442682,
0.020975713,
0.009621468,
0.023464136,
0.014982652,
0.013849182,
-0.028193442,
-0.012917652,
0.00057243503,
0.0057780924,
-0.008214402,
0.029053316,
0.042211995,
0.021184167,
-0.026056785,
0.021666218,
0.03835559,
0.003113786,
0.0034590382,
-0.004631594,
0.026030729,
-0.0033026976,
0.00988855,
-0.020519719,
-0.03817319,
0.015152021,
-0.00895702,
0.013562557,
0.0026643064,
0.020259151,
0.027463851,
0.009087304,
0.011106705,
0.011386815,
-0.016129151,
0.011888408,
0.014083693,
0.0077388654,
0.0025584507,
0.017223535,
0.021040855,
0.018500319,
-0.021939814,
0.02991319,
-0.003980174,
0.0041821143,
-0.018839056,
-0.0046967356,
-0.006172201,
-0.009562841,
-0.012878566,
0.0076411525,
-0.0029460452,
-0.024636691,
-0.006520711,
-0.02457155,
-0.014292147,
-0.018773913,
0.007921263,
-0.00240211,
-0.010859165,
-0.037078805,
0.011002478,
0.033613253,
0.026356438,
0.024337038,
-0.020311264,
0.004973589,
0.031007575,
-0.017627416,
0.0012629399,
-0.0058855764,
0.0012523542,
0.003651207,
0.0041886284,
-0.0016774056,
0.00054434256,
-0.005442611,
-0.010194718,
0.00015857998,
-0.02018098,
0.025718048,
0.009758267,
-0.009634497,
0.013562557,
0.004638108,
0.004569709,
-0.020558804,
0.0011570841,
0.020545775,
-0.03171111,
-0.008592225,
-0.019920412,
0.011868866,
0.0041234866,
0.010201232,
-0.00993415,
-0.0023630247,
-0.010266374,
-0.01171904,
0.009549812,
0.007764922,
0.002073143,
0.010318487,
0.022656376,
0.009758267,
0.020858457,
0.022630319,
-0.017093252,
0.0054588965,
0.006299228,
0.016103094,
-0.020415492,
-0.023854988,
0.01760136,
0.014435459,
-0.0070092753,
-0.016715428,
-0.01767953,
0.01154967,
0.04945578,
0.0077779507,
-0.0005565567,
-0.057116475,
-0.0069180764,
-0.005126673,
-0.0009771294,
-0.013113078,
0.009061247,
-0.006266657,
0.018682715,
-0.023372937,
-0.03679218,
0.025470508,
-0.029235713,
-0.0022750832,
0.009588897,
-0.03728726,
0.0033580682,
0.006269914,
0.0050191884,
-0.023229625,
-0.01816158,
-0.010872194,
-0.013549529,
-0.016806627,
-0.0026936203,
0.025574734,
-0.016077036,
0.009334844,
0.025991645,
0.01595978,
0.017002054,
-0.008742051,
0.0030714436,
0.003170785,
-0.008624796,
-0.034551296,
0.02042852,
-0.011732068,
0.0052862703,
0.015673157,
-0.01187538,
0.020063724,
0.032701265,
-0.022395808,
-0.012337888,
-0.021887701,
-0.05810663,
0.0034590382,
0.0038075477,
-0.014292147,
-0.003253841,
-0.048856474,
0.011901437,
0.0698843,
-0.0123574305,
0.007387099,
0.004178857,
0.0261089,
-0.014891453,
-0.00044052253,
-0.023008142,
0.01167344,
0.013523472,
0.0025747363,
0.0032929264,
-0.012885081,
0.0127287395,
0.022278551,
-0.00762161,
0.011087162,
-0.013836153,
-0.010038377,
0.017445019,
-0.010142604,
0.017705586,
-0.016559087,
-0.009712667,
-0.014096721,
-0.009517241,
-0.03679218,
-0.007204701,
0.040596474,
0.015191106,
-0.018448204,
0.024350066,
-0.024623662,
-0.006006089,
0.018435176,
-0.02033732,
0.02983502,
-0.017640444,
0.03379565,
0.017874954,
0.0019835727,
-0.024284925,
0.008018976,
0.007562982,
-0.0006355413,
0.027672306,
0.0033873823,
-0.027099058,
0.006735679,
0.02010281,
0.0038596615,
-0.023451107,
-0.03720909,
0.031580824,
0.00895702,
0.0023027684,
-0.014148835,
-0.01338016,
-0.026864545,
0.040909152,
-0.0057487786,
0.0011603412,
-0.0039964593,
-0.016767541,
-0.007263329,
0.04846562,
-0.015621043,
0.021027826,
-0.009497698,
0.01361467,
-0.016897826,
0.009250159,
-0.02011584,
-0.00008407385,
0.009947178,
0.028349783,
-0.015608015,
0.005869291,
-0.0013459958,
0.003250584,
-0.019360192,
-0.0051592435,
-0.012266232,
0.03606259,
0.011341216,
0.0058497484,
0.0037261203,
-0.008637824,
-0.008038518,
-0.0062829424,
-0.0029786164,
-0.02311237,
0.02067606,
0.0050615305,
0.04507824,
0.01751016,
-0.0239983,
0.005136444,
-0.030590666,
0.008116689,
-0.022148268,
-0.017536217,
0.014240034,
-0.029496282,
-0.012676626,
0.008729023,
0.0048595904,
0.026200099,
0.0079408055,
-0.009836436,
-0.006328542,
0.006133116,
-0.027411738,
-0.0016651915,
0.021822559,
0.012129433,
-0.020845428,
0.00050729304,
-0.0044557103,
-0.03574991,
0.014435459,
-0.0014070665,
-0.03491609,
-0.012175033,
-0.0019314593,
0.007667209,
-0.021796502,
-0.014096721,
0.0128525095,
-0.0023092825,
0.0062503717,
0.014578772,
-0.027906818,
0.013653756,
-0.016090065,
-0.010435742,
0.022239467,
-0.017041137,
-0.009999292,
-0.0025193654,
0.016663315,
0.016415775,
-0.016767541,
-0.006722651,
-0.022434892,
0.02941811,
-0.020988742,
0.00960844,
0.0056575797,
-0.021861643,
-0.030147702,
0.0013264533,
-0.007856121,
-0.014383346,
0.016389718,
0.0065532816,
-0.017887983,
0.015699213,
-0.015816469,
-0.014761169,
0.011575727,
-0.024115555,
-0.020845428,
0.001319939,
-0.023529278,
0.034499183,
0.010930821,
0.013354103,
-0.0015072222,
-0.02480606,
-0.04661559,
0.005940947,
-0.0054849535,
0.0012922537,
0.02691666,
0.022760602,
0.019425334,
0.0066184234,
0.0121815475,
0.00038840895,
-0.0034232102,
0.017992212,
-0.0038303474,
0.005605466,
0.009992777,
-0.008846279,
-0.006963676,
-0.015777383,
0.006468597,
0.01361467,
0.00074750406,
0.03194562,
-0.009940663,
0.013308504,
-0.0014551086,
-0.0007666395,
-0.00374892,
-0.0019184309,
-0.014669971,
-0.005879062,
0.014682999,
-0.026617007,
0.019724987,
0.020689089,
-0.006295971,
0.0121098915,
0.0112630455,
-0.003146357,
-0.03674007,
-0.013171705,
0.012565885,
-0.0142660905,
0.019933442,
-0.00053049985,
0.005136444,
0.0107679665,
-0.0044263965,
-0.022148268,
-0.009093818,
-0.0043970826,
0.0008000248,
0.0036772639,
0.0031593852,
-0.016168235,
-0.0037717198,
0.01021426,
0.016090065,
-0.015621043,
0.009823408,
-0.017223535,
-0.007908234,
-0.036609784,
0.0111913895,
-0.0047879345,
-0.030773064,
-0.018656658,
-0.0020308008,
-0.029001202,
-0.02392013,
-0.003680521,
0.0016619344,
-0.038225304,
0.016819656,
0.01556893,
-0.026121927,
-0.014422431,
0.012911137,
-0.026226155,
-0.013692841,
0.0058139204,
0.16697188,
0.027333569,
-0.02415464,
0.017471075,
-0.02011584,
0.009556326,
0.047683917,
0.004937761,
-0.013139134,
0.018044325,
0.024623662,
-0.00689202,
-0.013367131,
0.008657367,
0.028818805,
-0.01139333,
-0.02642158,
-0.031606883,
-0.0030975004,
-0.035958365,
-0.0028450752,
-0.0020210294,
-0.009614954,
-0.004309141,
-0.0056836363,
0.008416342,
0.0018581746,
-0.0003342597,
0.0418472,
0.017210508,
-0.008246973,
0.020389436,
-0.011725553,
0.0007719323,
-0.019073566,
-0.012135948,
-0.0156471,
-0.0016318063,
-0.010181689,
0.012305317,
-0.011119734,
-0.017575301,
-0.010794024,
0.027672306,
-0.012644055,
0.03679218,
0.02124931,
-0.004742335,
-0.0071395594,
0.015803441,
-0.03728726,
-0.00084684556,
0.0024623664,
0.011699497,
-0.017562274,
-0.003752177,
0.036505558,
0.012096863,
-0.011171847,
-0.0009209445,
-0.015881611,
0.0050941017,
-0.021145081,
0.01929505,
0.001307725,
0.03113786,
-0.010885222,
-0.016520003,
-0.031059688,
-0.007602067,
0.02100177,
-0.015438646,
-0.020141896,
0.0027457338,
0.008038518,
-0.00078373926,
0.030694894,
0.0049605607,
-0.0083121145,
0.0059246616,
-0.016389718,
-0.0072177295,
-0.0028906746,
0.01159527,
-0.035046376,
-0.025483537,
0.024167668,
0.04361906,
0.021171138,
-0.026734263,
-0.009673581,
-0.015256248,
0.016194293,
-0.0042244564,
-0.013940381,
-0.015868582,
-0.0055891806,
-0.018904198,
-0.015034765,
0.008299086,
-0.030225871,
0.079056285,
0.0025845075,
0.0033710967,
-0.01751016,
0.015621043,
-0.00081427454,
0.013979466,
0.0083121145,
-0.0053904974,
-0.011438929,
-0.022526091,
0.0033580682,
0.0013142391,
-0.0023174253,
0.004331941,
-0.015634071,
-0.029626565,
-0.004918218,
0.014148835,
-0.00092338736,
-0.023451107,
0.034655526,
0.013836153,
-0.007764922,
-0.011197904,
-0.019555617,
0.016129151,
0.006110316,
-0.022734545,
-0.009829923,
-0.024167668,
0.020311264,
0.015555901,
0.0016269205,
0.010031862,
0.020037668,
0.0063871695,
0.0055533526,
0.0031300713,
0.0017018338,
-0.036192875,
0.026838489,
0.0029037031,
-0.013849182,
-0.011497557,
-0.0019705445,
-0.0013679813,
-0.024597606,
-0.010442257,
-0.008566168,
-0.013888267,
-0.008286058,
-0.0100253485,
0.04825717,
-0.015594986,
0.0039997166,
-0.02018098,
-0.013731926,
0.023894073,
-0.032258302,
0.034316786,
0.012461658,
-0.014200948,
0.0099732345,
0.0059898035,
-0.1632197,
0.0015137364,
0.000020916677,
-0.021327479,
0.037573885,
0.0044654817,
0.016181264,
-0.02651278,
-0.0017116051,
0.0035762938,
-0.0067812786,
0.0071330452,
-0.01556893,
-0.022669403,
0.0032424412,
-0.00323267,
-0.00029293526,
0.044374708,
0.017640444,
0.0077323513,
0.01167344,
-0.026942717,
0.024428237,
-0.013295475,
-0.0074392124,
-0.00009369247,
-0.019816186,
0.039163347,
0.015529844,
-0.0083512,
0.0006200701,
-0.015112936,
0.033196345,
-0.005559867,
0.02975685,
-0.01889117,
-0.01293068,
-0.016871769,
-0.005002903,
-0.0013769383,
0.008618282,
0.0035372088,
0.022708489,
0.007953834,
0.010181689,
0.01159527,
0.017080223,
-0.037339374,
-0.000004322653,
-0.0030893576,
0.008624796,
-0.037756283,
0.0071330452,
0.012324859,
0.014031579,
0.020467605,
-0.001776747,
-0.0135365,
0.021288395,
-0.03064278,
-0.004784677,
-0.02002464,
0.022708489,
0.0019184309,
0.0041560573,
-0.036427386,
0.0040616016,
-0.011093677,
0.005113644,
0.021835586,
-0.024845146,
-0.03851193,
-0.000080511396,
-0.02367259,
0.0167024,
0.01954259,
0.006729165,
0.009738724,
-0.0065793386,
-0.018813,
-0.021014798,
0.016168235,
-0.01954259,
-0.012963251,
-0.0032912977,
-0.0035958365,
0.006820364,
0.017445019,
0.028636407,
-0.024428237,
-0.006826878,
-0.026356438,
0.0065109394,
-0.01847426,
-0.0031040146,
0.027125115,
-0.015920697,
0.01212292,
0.009543298,
0.013197762,
0.005302556,
-0.006563053,
-0.02173136,
-0.004136515,
0.028011044,
-0.0052699847,
-0.013282446,
0.031372372,
0.010018834,
-0.0057585496,
-0.0014013665,
-0.006709622,
0.0019233165,
0.010728882,
-0.000076745375,
-0.0011318417,
-0.016572116,
-0.0016228491,
0.0128525095,
-0.017940097,
0.05925313,
-0.005774835,
-0.030356156,
-0.010552999,
0.0040941723,
0.004449196,
-0.11590058,
-0.017366847,
-0.0061135734,
-0.0007515754,
-0.01074191,
0.010950364,
-0.0043547405,
0.033196345,
-0.011855838,
0.03363931,
-0.045599375,
-0.029704737,
0.0148132825,
-0.002138285,
0.0021610847,
-0.027385682,
0.0046902215,
0.0019803157,
-0.035515398,
0.03809502,
-0.014604828,
0.010305459,
-0.003069815,
-0.014969624,
-0.012520285,
-0.0012401402,
-0.010624655,
0.015998866,
0.0014282375,
0.009947178,
0.0028809034,
0.012285775,
0.008058061,
0.016767541,
0.0016000496,
-0.0029069602,
-0.0068855057,
-0.011008992,
0.024584578,
-0.0187218,
0.0044296538,
0.022447921,
0.030538553,
0.021105997,
0.005315584,
0.008468456,
-0.044661332,
0.0012287403,
0.0042244564,
-0.0065467674,
-0.012103377,
-0.02010281,
-0.004289598,
0.0010439,
0.022317637,
-0.0052341567,
0.016233377,
-0.012539828,
-0.024975428,
0.012370459,
0.008930963,
0.0070744175,
-0.03543723,
0.038251363,
0.012578913,
-0.01637669,
-0.009921121,
-0.027177228,
-0.016011896,
-0.0043579973,
-0.021171138,
0.010956879,
-0.004944275,
-0.013445302,
-0.020975713,
0.0059474614,
-0.0021089711,
0.011236989,
-0.004283084,
0.012455144,
-0.024532463,
-0.016624229,
0.010246831,
-0.005963747,
0.001533279,
0.033430856,
-0.004273313,
-0.01378404,
0.018878141,
-0.008774622,
0.025275081,
0.03632316,
0.017523188,
-0.019229908,
0.009399986,
0.018213693,
0.0000831069,
-0.013979466,
0.028584294,
0.019581674,
-0.020063724,
-0.017054167,
-0.04849168,
0.02756808,
0.015152021,
0.0012955108,
-0.00045395806,
0.009986263,
0.014630885,
0.01086568,
-0.013204277,
0.013497415,
0.0013459958,
0.0048628477,
0.0016920625,
0.01005792,
-0.017705586,
-0.0074326983,
0.01735382,
0.008403313,
0.025561707,
0.011894923,
0.00425377,
0.023828931,
-0.01001232,
0.027281456,
-0.012240175,
0.0077388654,
-0.0014396374,
0.034394957,
-0.026486723,
0.0051527293,
0.0052830135,
-0.022682432,
-0.0019102881,
0.022825744,
0.0023955957,
-0.043280322,
-0.0033254973,
0.023503222,
0.02091057,
0.010233803,
-0.028245555,
-0.024206754,
0.018096438,
0.007321957,
0.0014779083,
0.0153604755,
-0.029235713,
0.018330948,
0.0116343545,
-0.015386532,
0.015425617,
-0.010963392,
-0.009198045,
-0.02123628,
-0.04484373,
0.02230461,
0.0011171846,
0.010579055,
0.015073851,
-0.0148132825,
0.017275648,
-0.014748141,
-0.013953409,
0.00782355,
0.0010341287,
-0.009465127,
-0.017731642,
0.023034198,
-0.000009892164,
0.007106988,
-0.008937477,
0.004918218,
0.018630601,
0.014331232,
0.015451674,
0.02481909,
-0.0015251363,
0.018904198,
-0.002333711,
0.00039309103,
0.012819938,
-0.018747857,
-0.00814926,
0.014891453,
0.02124931,
-0.007817036,
-0.029808963,
0.02926177,
-0.024063442,
0.0042863414,
0.0053253556,
0.0030616724,
0.011556185,
-0.0006282128,
0.0016464632,
0.017445019,
-0.013432273,
-0.01556893,
0.030121645,
0.034837924,
0.018513346,
0.017796785,
0.0005952347,
-0.027385682,
0.000741397,
0.019399278,
-0.03332663,
-0.019477447,
-0.018878141,
0.0009266444,
0.030720951,
0.03421256,
-0.030277986,
0.00022901472,
0.005436097,
-0.018383062,
0.0041332575,
0.0153083615,
-0.006295971,
0.009002619,
-0.004742335,
0.015594986,
0.010963392,
-0.01848729,
0.0068399063,
0.0167936,
0.014774198,
-0.033118173,
0.02440218,
-0.0018093181,
0.014200948,
0.00036499856,
-0.032935776,
0.009334844,
-0.0059051192,
-0.02676032,
-0.01952956,
0.0108396225,
0.008520569,
0.087029666,
-0.032492813,
0.0015365361,
-0.010142604,
-0.024376122,
-0.0009999292,
-0.001117999,
-0.008468456,
-0.0031658995,
-0.03079912,
-0.0037717198,
-0.014005522,
0.023294767,
-0.03931969,
-0.050471995,
-0.0021154853,
-0.0085596545,
0.030356156,
0.0064425403,
-0.035150602,
0.021640161,
0.0020308008,
0.01896934,
-0.016663315,
-0.009217588,
-0.0068529346,
0.0059735184,
-0.021184167,
-0.014083693,
-0.004673936,
0.028427953,
-0.0023890815,
-0.042654958,
-0.007589039,
-0.0036772639,
-0.026069814,
-0.007667209,
-0.031502653,
0.009536783,
0.008071089,
-0.018839056,
0.032935776,
-0.00762161,
-0.015295333,
0.014109749,
-0.0364795,
-0.010585569,
-0.00042423705,
-0.021040855
] |
The N-myc downstream regulated gene 1 (NDRG1) is significantly associated with advanced tumor stages and poor survival of hepatocellular carcinoma (HCC), thereby implicating it as a potential target for HCC treatment. We aim to further understand its biological roles in hepatocarcinogenesis, as a means to exploit it for therapeutic purposes. By screening using the ProtoArray® Human Protein Microarrays, we identified glycogen synthase kinase 3β (GSK-3β) and the orphan nuclear receptor (Nur77) as potential interaction partners of NDRG1. These interactions were confirmed in HCC | [
-0.033060443,
-0.02029626,
0.011123265,
-0.029966911,
-0.013604816,
0.014674102,
-0.012838158,
0.027814887,
-0.038036995,
-0.013692242,
0.012475004,
-0.010101055,
0.005349793,
0.0034734984,
-0.019085748,
0.0019906207,
0.035024162,
-0.02499036,
-0.0025992393,
0.00030346878,
-0.01640917,
0.013497215,
-0.0039745164,
-0.013033185,
0.008641714,
0.022959389,
-0.0037626764,
-0.030235913,
0.006920097,
-0.012757457,
0.005477569,
-0.00313052,
0.017027877,
0.0012542255,
0.023658795,
-0.007209275,
-0.0011289711,
-0.00092133455,
0.010208656,
-0.012172376,
0.00870224,
0.000553137,
-0.0014677464,
0.0030901695,
0.0023857185,
0.0096639255,
0.013551015,
-0.03370605,
-0.009428548,
0.018614992,
-0.0062509524,
0.01821149,
-0.0109887635,
-0.025245912,
-0.0018712507,
0.014176447,
0.0060223,
0.008426513,
0.008513939,
-0.010538184,
-0.014337849,
0.0028009915,
-0.038252197,
0.018103888,
0.01160747,
0.020430762,
-0.014593401,
-0.0073034256,
-0.0014030177,
-0.009522699,
0.04917371,
0.0192606,
-0.0039072656,
0.0050370772,
0.018709144,
-0.027680388,
-0.021748876,
0.002157066,
0.0042468817,
-0.0033087344,
0.02121087,
-0.010955138,
0.004751262,
0.01826529,
0.011378818,
0.010787012,
-0.01059871,
0.0060525625,
-0.00034045667,
-0.011257767,
0.017216178,
0.022367582,
0.008406337,
0.008231485,
-0.0026984343,
-0.014230248,
0.004986639,
0.016947176,
0.0011432618,
-0.013907444,
-0.005282542,
0.026671626,
0.0036382626,
-0.0074446523,
-0.015292808,
0.011015664,
-0.009858952,
0.0073639513,
0.010921513,
0.0032919217,
-0.010235556,
0.035884973,
-0.017538982,
-0.013369438,
0.02509796,
-0.016234318,
0.037902493,
0.007128574,
-0.0037761265,
-0.017081678,
0.009441998,
0.036019474,
0.018547742,
-0.016113266,
0.018978147,
0.036019474,
-0.015037256,
0.0145530505,
-0.026940629,
-0.0023285553,
0.023510844,
0.004858863,
0.027572786,
0.008890542,
-0.025272813,
0.0035777371,
-0.023551194,
-0.0055918954,
-0.017646583,
-0.038763303,
-0.004357845,
0.033437047,
-0.03281834,
0.002099903,
-0.030612517,
0.01648987,
0.034378555,
0.0067788702,
0.008587914,
-0.0013332451,
0.006412354,
-0.021695076,
0.018628443,
-0.01061216,
0.0074581024,
0.022771087,
0.008070083,
0.017848335,
-0.027814887,
-0.00045982664,
0.014660652,
-0.020565264,
0.014324399,
-0.0008221398,
0.034136456,
0.01837289,
0.006298028,
-0.0062576775,
0.004653748,
-0.02794939,
-0.0056288834,
0.04519247,
-0.024788607,
0.019637203,
-0.013510665,
-0.0059382366,
0.015306259,
0.030262813,
-0.019583402,
0.0074850027,
0.0007750643,
0.0036180874,
0.030182112,
-0.013463589,
-0.028460495,
0.0018309002,
0.018117338,
-0.0056793215,
-0.021681625,
-0.032656938,
0.003557562,
0.010706311,
-0.0016980801,
-0.01636882,
-0.63269454,
-0.030585617,
0.02800319,
-0.0070276977,
-0.00072967005,
0.022703836,
0.027115481,
-0.0085004885,
-0.012575881,
0.02605292,
-0.00021467684,
0.01249518,
0.006684719,
-0.011520044,
-0.033248745,
-0.020565264,
-0.00874259,
-0.0020461024,
0.031016022,
-0.007538803,
-0.033114243,
0.005380056,
-0.006772145,
-0.0029993812,
0.009892577,
0.03179613,
0.009502524,
-0.019691003,
0.005218654,
0.030182112,
-0.022542434,
0.031527128,
0.005205204,
0.00871569,
0.05412336,
-0.016624372,
-0.0023403242,
-0.0024412002,
0.027290333,
0.034028854,
-0.015104506,
0.009959828,
0.032172732,
-0.000057793568,
-0.03176923,
0.033975054,
0.016032565,
-0.01058526,
-0.003745864,
-0.0065165926,
-0.015615612,
0.0059920372,
-0.021937177,
-0.014216797,
-0.0080835335,
-0.011573845,
0.017296879,
-0.034432355,
0.009287321,
0.010760112,
0.0090855695,
0.032334134,
0.010544909,
-0.023604995,
-0.0048824004,
-0.0023689058,
-0.023591544,
0.005060615,
0.0022411295,
0.010518009,
0.011957174,
0.03779489,
0.0030834444,
0.0057297596,
0.029106101,
0.044977266,
-0.00230838,
0.026658176,
-0.013120611,
0.021089818,
0.006802408,
0.002407575,
-0.024896208,
0.021076368,
0.033302546,
-0.016691623,
-0.013423239,
0.016839575,
0.015938414,
-0.00916627,
0.016826125,
-0.008144059,
-0.010672686,
-0.008903992,
0.0025605704,
0.03564287,
-0.021910276,
0.019623753,
0.012838158,
-0.022596234,
-0.009441998,
-0.013611541,
-0.0012012656,
-0.016072916,
0.009132645,
-0.0005939077,
-0.04430476,
0.008399612,
0.025568714,
-0.04061942,
0.00033120968,
0.0006077782,
-0.0099934535,
-0.0014719496,
0.0066544563,
-0.019986907,
0.014216797,
0.0018779758,
0.00139293,
-0.032307234,
0.0091595445,
0.005074065,
0.010645785,
-0.011526769,
0.02220618,
-0.0041090176,
0.010215381,
-0.0075724283,
-0.0070209727,
-0.004482259,
0.026160521,
-0.02115707,
0.01648987,
-0.017162377,
0.03292594,
-0.0032431649,
0.010773562,
0.008903992,
0.004741174,
-0.04454686,
-0.026886828,
-0.013134061,
0.012084951,
0.004512522,
0.0085811885,
0.006980622,
-0.01842669,
-1.4612579e-7,
0.012306877,
0.008554288,
-0.006556943,
-0.005615433,
-0.0004884082,
0.018561192,
0.0043107695,
-0.013853644,
0.001993983,
-0.0069940723,
-0.004647023,
0.006291303,
0.008023008,
0.00923352,
-0.016799225,
-0.012434654,
-0.01735068,
-0.03671888,
0.005060615,
0.02497691,
-0.0029472618,
-0.019838955,
-0.014324399,
-0.009865677,
-0.012663307,
0.023739496,
0.019031947,
0.0017871873,
0.001778781,
-0.008977968,
-0.003853465,
-0.008877092,
0.0024126188,
-0.024183352,
-0.003093532,
0.0030464565,
0.023766397,
0.035320066,
0.025447663,
-0.002545439,
0.017068228,
0.03193063,
-0.047021687,
0.029509606,
-0.025272813,
0.017969387,
0.004156093,
-0.027734187,
0.013893994,
-0.008157509,
-0.01744483,
0.031473327,
0.024156451,
-0.022959389,
-0.00460331,
-0.010672686,
0.010006904,
-0.0010768517,
0.0051076906,
0.00097597577,
-0.019502701,
-0.007437927,
0.00624759,
0.003702151,
0.004670561,
-0.01107619,
-0.003947616,
0.0031170698,
-0.0110694645,
-0.026416074,
-0.012918859,
-0.017592782,
0.0012794446,
0.0031406076,
0.019408552,
0.008608089,
-0.012683481,
0.004653748,
-0.009314221,
0.028756399,
0.007935583,
-0.008204585,
-0.010854263,
0.024573404,
-0.009065394,
0.003571012,
0.0019637204,
0.0063215657,
-0.0077472804,
-0.015171757,
0.03693408,
0.007626229,
-0.0059617744,
-0.0076598544,
0.025770467,
0.005538095,
-0.01846704,
-0.011345193,
0.006825946,
-0.004371295,
-0.02126467,
0.023968149,
-0.005148041,
0.035185564,
-0.021587474,
-0.0051783035,
0.007827981,
-0.019368201,
0.008567738,
0.013429964,
0.056490585,
0.024438903,
-0.0069402717,
0.009381472,
0.0075657032,
-0.018292189,
0.01642262,
0.01008088,
0.026200872,
0.0022075041,
-0.018762944,
0.013194587,
-0.008547564,
0.009253696,
-0.0026614463,
-0.041076727,
0.006382091,
0.011688171,
0.01916645,
-0.011230866,
0.023443593,
0.006113088,
-0.013880543,
-0.022663485,
0.030558717,
0.026200872,
-0.003350766,
-0.014687552,
-0.019516151,
0.025743566,
-0.015844265,
0.006641006,
0.019045398,
0.0070276977,
0.01745828,
0.003490311,
-0.010538184,
-0.016557122,
0.015615612,
-0.01922025,
-0.0029153177,
-0.008856917,
0.020632515,
0.0063484656,
0.004230069,
-0.009011594,
0.029240603,
0.008991418,
-0.017552432,
-0.00026753166,
-0.0082516605,
-0.009172995,
0.008924168,
0.01639572,
0.011896648,
-0.006809133,
-0.002923724,
0.008924168,
-0.0052220165,
0.013577916,
0.017929036,
0.015548361,
-0.020498013,
-0.039032303,
-0.004757987,
-0.009038494,
0.026268123,
0.02704823,
-0.003557562,
0.0056490586,
0.024802057,
0.026698526,
0.00070445106,
-0.029455805,
0.03297974,
0.0005884436,
0.004055217,
-0.005181666,
-0.010518009,
-0.0023504118,
0.0053228927,
0.009563049,
-0.005891161,
-0.020390412,
-0.015951864,
0.0024126188,
0.013907444,
-0.009858952,
0.023618445,
0.03763349,
0.03580427,
-0.01636882,
-0.00007182164,
0.021116719,
0.0096303,
-0.021869926,
-0.0037963018,
0.023134239,
0.004647023,
0.0048286,
-0.012273252,
-0.02803009,
0.012575881,
0.005601983,
-0.0059954,
0.0067855953,
0.018614992,
-0.01059871,
0.018897446,
0.015077606,
0.013073536,
-0.017848335,
-0.010444033,
0.0035676495,
0.0040283166,
-0.013349263,
0.006388816,
-0.022407932,
-0.00095832243,
-0.014324399,
-0.008164234,
-0.026348824,
0.010961863,
-0.015117956,
0.008110434,
-0.018628443,
0.0014189897,
-0.005773472,
0.010302807,
-0.0057936474,
-0.0036954258,
-0.004808425,
-0.008628264,
-0.034405455,
-0.024654105,
-0.016557122,
0.026833028,
-0.01635537,
-0.021358822,
0.029455805,
0.005174941,
0.0056927716,
0.010396957,
-0.009011594,
0.021089818,
0.016046016,
-0.012293427,
-0.020888066,
-0.010410408,
-0.020672863,
0.0022865236,
-0.023766397,
0.013719142,
-0.008547564,
-0.0040955674,
-0.0032112207,
0.0034869486,
0.00029863513,
0.022394482,
0.00022318825,
0.0024781881,
-0.013712417,
0.0290254,
-0.0010407045,
-0.007908682,
0.0035172114,
0.01211185,
-0.013187862,
-0.025461113,
-0.024775157,
-0.0066746315,
-0.013510665,
0.014741353,
-0.0030346876,
-0.011997525,
0.015682863,
0.02706168,
-0.0068999217,
0.006839396,
0.007263075,
0.0091595445,
0.011849573,
-0.0015551724,
0.010067429,
-0.0117352465,
-0.00920662,
0.0051379534,
-0.015346609,
0.033840552,
0.007612779,
-0.011452794,
-0.0012567474,
-0.018144239,
0.0038063894,
-0.0061467136,
-0.00065275206,
-0.015494561,
0.02511141,
-0.0063652783,
-0.008076808,
-0.0121454755,
-0.017323779,
-0.022569334,
-0.010982038,
0.0063215657,
-0.025649415,
-0.019704454,
-0.0061568012,
0.029536506,
-0.0050572525,
0.0067755077,
-0.03553527,
-0.011641095,
0.01638227,
0.0017207772,
-0.00022339841,
-0.00061282195,
0.0048050624,
-0.018736044,
-0.014687552,
-0.015978765,
-0.028783299,
-0.0017064865,
0.0025286262,
0.04532697,
0.029724808,
0.032199632,
0.0073841265,
0.018561192,
0.012064775,
0.016072916,
-0.0011020708,
-0.012172376,
0.011008939,
-0.030989122,
0.0149700055,
0.00408548,
-0.012239627,
0.025662865,
0.002960712,
0.015575262,
-0.0025034072,
-0.004916026,
-0.023631895,
-0.005689409,
-0.03957031,
-0.041426428,
0.013907444,
-0.02512486,
-0.010464208,
-0.027707288,
-0.026550574,
0.023685696,
-0.0048185126,
0.014822054,
-0.016933726,
0.0242506,
-0.015521461,
0.004596585,
0.0060223,
0.022663485,
-0.0052421917,
-0.014324399,
0.010457483,
-0.02125122,
-0.0045528724,
0.0007448015,
0.027478635,
0.002458013,
-0.017592782,
0.012844883,
-0.0010541547,
-0.015629062,
-0.022017878,
-0.008648439,
-0.025703216,
-0.0140553955,
-0.017512081,
-0.008466863,
-0.035158664,
-0.00874259,
0.022744186,
-0.022609685,
0.012851608,
-0.0043343073,
-0.006173614,
0.015346609,
-0.012932309,
0.029133001,
-0.019785155,
0.014041945,
0.021762326,
-0.016315019,
-0.015171757,
-0.025340063,
0.022582784,
-0.020699764,
0.032199632,
0.014808604,
-0.0035474743,
-0.015803915,
-0.002760641,
0.0071823746,
-0.017848335,
-0.038870905,
0.017848335,
0.013033185,
0.0014980093,
-0.014983456,
-0.009623575,
-0.018036637,
0.0062946654,
0.0016577297,
-0.0025538453,
0.0048555005,
-0.0017485181,
-0.003920716,
0.01837289,
-0.0041022925,
0.007128574,
-0.01062561,
-0.01930095,
-0.0076665794,
-0.028594997,
-0.00040203307,
-0.010948413,
-0.0065098675,
0.02706168,
0.0011415806,
-0.0077607306,
0.014862404,
-0.015373509,
0.03211893,
-0.02118397,
-0.021829575,
0.04048492,
-0.0001152719,
-0.02410265,
0.022421382,
0.014095746,
0.010201931,
-0.0005262367,
-0.0023588182,
-0.010518009,
-0.03553527,
0.0002532409,
0.016597472,
0.0018208126,
-0.024398552,
0.025340063,
-0.010995489,
-0.012609506,
-0.025568714,
-0.017498631,
0.010349882,
-0.057243794,
-0.009260421,
-0.016099816,
0.016099816,
0.018910896,
-0.0073034256,
-0.0036180874,
0.006203877,
0.043067347,
-0.008446688,
0.022502083,
0.00058255915,
-0.008890542,
-0.013221487,
0.013194587,
-0.007888507,
-0.04995382,
0.029644107,
-0.035131764,
-0.027922489,
-0.015508011,
-0.011325018,
0.0066141062,
0.025192112,
-0.012622956,
0.024371652,
-0.008608089,
0.01835944,
0.0013307232,
-0.003715601,
0.042663842,
-0.008177685,
0.0022898861,
0.011298117,
-0.006106363,
-0.018103888,
-0.011950449,
-0.03639608,
-0.005985312,
-0.017982837,
-0.013066811,
-0.017148927,
0.024573404,
-0.011452794,
0.025555264,
-0.011190516,
-0.01350394,
-0.028137691,
0.02299974,
0.010578535,
-0.0070142476,
-0.015924966,
-0.011257767,
-0.014768253,
0.0071958248,
-0.035858072,
-0.0037189636,
-0.0047445367,
-0.048635703,
-0.04726379,
0.0019872582,
-0.023483943,
0.027922489,
-0.0035676495,
-0.014230248,
-0.016086366,
-0.0013021416,
-0.03653058,
-0.013584641,
-0.002880011,
0.016543671,
0.005696134,
0.021627825,
-0.029321304,
0.007935583,
-0.005803735,
0.013470314,
0.00626104,
-0.02512486,
0.017148927,
0.0023218303,
0.021950627,
0.016503321,
-0.019516151,
-0.0048824004,
0.017498631,
0.00923352,
-0.013746043,
0.019691003,
-0.03655748,
0.024842408,
-0.019973457,
0.0006519114,
-0.0034146542,
0.010713036,
0.007807806,
-0.016046016,
-0.0029724808,
0.015225558,
0.00017254007,
-0.0030699943,
0.0071554743,
0.008756041,
0.005255642,
-0.0028144417,
-0.008439963,
-0.01012123,
0.014257148,
-0.006136626,
-0.0060189376,
0.030478016,
0.0026513587,
0.027182732,
0.0145530505,
-0.015898066,
0.0019435452,
-0.004172906,
-0.021641275,
-0.0027303782,
0.005484294,
-0.01008088,
-0.0074648275,
-0.013463589,
0.0032465274,
-0.02508451,
-0.0046739234,
-0.011338468,
-0.026335374,
-0.025353514,
0.022784537,
-0.008372712,
-0.0288909,
-0.03483586,
0.01159402,
-0.017538982,
0.0044351835,
-0.014660652,
0.013302187,
-0.023726046,
-0.025192112,
0.008150784,
-0.0060054874,
-0.015871165,
0.013160962,
-0.018588092,
-0.0068427585,
0.0144051,
0.20551813,
-0.009650475,
0.004512522,
0.008292011,
0.020659413,
-0.0024277503,
0.020067608,
-0.00085660577,
-0.014270598,
-0.0014442087,
0.022663485,
-0.0015618975,
-0.026954079,
-0.0048017,
0.017175827,
-0.004119105,
-0.032414835,
-0.0060223,
-0.019771704,
-0.011661271,
0.01253553,
-0.00817096,
-0.008150784,
-0.009764801,
0.026510226,
0.005090878,
-0.016220868,
0.006980622,
0.01737758,
0.010558359,
-0.0240085,
0.0035172114,
-0.007646404,
-0.0037055134,
0.014593401,
-0.00093310344,
-0.006795683,
-0.01646297,
-0.009428548,
-0.0048017,
-0.0043477574,
0.00004171645,
-0.01444545,
0.006069375,
0.0013324044,
-0.004156093,
-0.0051917536,
-0.001209672,
-0.006143351,
0.0051514036,
-0.063699864,
-0.0024546504,
0.03752589,
0.0289716,
-0.0027640036,
-0.0001759026,
0.004532697,
0.007895232,
-0.0032734277,
0.04172233,
-0.02129157,
0.010114505,
-0.01930095,
0.029106101,
-0.021049468,
0.023322541,
-0.024855858,
0.016610922,
0.017834885,
-0.013497215,
-0.007545528,
0.001872932,
0.0030145126,
0.003231396,
0.002841342,
-0.0028850548,
0.03472826,
0.016678173,
0.024506154,
0.030424215,
0.0012365722,
0.011277942,
-0.023779847,
-0.013658617,
-0.015144857,
-0.02980551,
0.0042905943,
0.013739318,
-0.019408552,
-0.02497691,
0.021869926,
0.012844883,
-0.010013629,
-0.011694896,
0.0020797278,
0.008365987,
0.01919335,
0.0050337147,
0.016651273,
-0.01646297,
-0.02317459,
0.07370676,
-0.0013635079,
0.01743138,
-0.024479253,
0.008090259,
-0.010524734,
0.011667996,
-0.008487038,
-0.000595589,
0.018682243,
-0.011856298,
0.004055217,
-0.018171139,
0.0060592876,
0.034593757,
0.019126099,
-0.021009117,
0.009307496,
-0.02500381,
-0.0056860466,
-0.026846478,
-0.015844265,
0.039408907,
-0.020767014,
-0.00049219106,
0.001930095,
-0.023309091,
-0.005003452,
-0.038279098,
0.00035958106,
-0.024869308,
0.0052018412,
-0.009885852,
0.003086807,
0.0055750827,
0.009744626,
-0.006237502,
-0.017000977,
0.017000977,
-0.00025555264,
-0.00024252283,
0.015333159,
0.0100741545,
0.0033406783,
-0.014943105,
0.007350501,
0.016879926,
-0.0061837016,
-0.0018678881,
-0.019583402,
-0.010228831,
-0.011493145,
-0.0052220165,
0.022448283,
-0.01642262,
-0.03696098,
-0.024613755,
0.019489251,
-0.00045520315,
-0.02988621,
0.00076749857,
0.038575,
-0.016853025,
0.0013895675,
0.0021402533,
-0.17076297,
0.010827363,
0.029751709,
-0.038305998,
0.021358822,
0.0057163094,
-0.0054607564,
-0.009872402,
-0.002182285,
0.012777632,
0.030209012,
-0.007848157,
-0.04156093,
-0.038682602,
0.018036637,
0.00139293,
-0.0014046989,
0.03653058,
0.008070083,
0.0114864195,
0.020807365,
-0.004300682,
-0.0037256887,
-0.003977879,
-0.017054778,
0.016099816,
-0.010733211,
-0.0117352465,
-0.025824267,
0.0014769934,
-0.00045310156,
0.017700383,
0.018601542,
0.012710381,
0.028245293,
-0.003080082,
0.003456686,
0.0050370772,
-0.019045398,
0.015602162,
0.00872914,
0.02605292,
0.03486276,
0.007121849,
-0.043578453,
0.028325994,
0.014351299,
-0.0023352804,
0.02022901,
-0.0018292189,
0.03564287,
-0.007814531,
0.025662865,
0.013813294,
0.02500381,
0.021439523,
0.029644107,
0.0023621807,
-0.0060357503,
-0.012475004,
-0.0036315375,
-0.016947176,
0.021318471,
0.00023726886,
0.0044923467,
-0.03176923,
-0.020968767,
-0.0030952133,
-0.034190256,
0.001241616,
-0.045649774,
-0.020632515,
0.017175827,
-0.016543671,
0.030047612,
0.0012063094,
-0.000883506,
0.015723214,
0.004488984,
0.0030363689,
0.004243519,
0.0043544825,
-0.026375724,
-0.02224653,
-0.0052724546,
0.008386162,
0.01353084,
0.019126099,
0.0032784715,
-0.0020881342,
0.03556217,
-0.024681006,
0.01634192,
-0.0084197875,
0.016099816,
0.01203115,
0.009764801,
-0.0028514296,
-0.013443414,
-0.0041695433,
0.026120171,
-0.0014416868,
-0.018883996,
0.0071016736,
0.037041683,
0.013698967,
-0.025945319,
0.022058228,
0.033302546,
-0.012670032,
-0.004858863,
-0.009361297,
0.017606232,
0.029240603,
-0.005860898,
0.041130528,
-0.008634989,
-0.0099934535,
-0.016516771,
-0.023066988,
0.05681339,
0.015494561,
-0.008379437,
-0.010127955,
0.009253696,
-0.020888066,
-0.12417169,
-0.02991311,
0.011062739,
0.00770693,
-0.02324184,
0.027680388,
0.003772764,
0.025219012,
-0.020713214,
0.026685076,
-0.03357155,
0.0033625348,
-0.010518009,
-0.0070276977,
0.012279977,
-0.007121849,
0.019502701,
-0.004451996,
-0.007908682,
0.033517748,
-0.007619504,
-0.010955138,
-0.016879926,
-0.012737282,
0.018803295,
0.0194758,
-0.025676316,
0.013746043,
0.009885852,
0.009872402,
0.004277144,
-0.019099198,
0.048608802,
-0.0122329015,
-0.042905945,
-0.035373867,
-0.0013189543,
-0.022609685,
0.034513056,
-0.018937796,
0.008561013,
0.017592782,
0.011950449,
0.0066813566,
-0.013537565,
0.010363332,
-0.02407575,
0.014297498,
0.029671008,
0.0064661545,
-0.009240245,
-0.0036180874,
-0.02126467,
-0.011392268,
0.028245293,
-0.026308473,
0.010874438,
0.022434833,
-0.022004427,
-0.000034098204,
-0.013355988,
-0.0067990455,
0.002816123,
0.004583135,
0.03575047,
0.004858863,
-0.01648987,
-0.033840552,
0.036019474,
-0.0143916495,
-0.014593401,
0.005914699,
-0.017068228,
-0.03187683,
-0.025474563,
0.021466423,
-0.008325636,
-0.022421382,
0.0027993103,
-0.038225297,
-0.019126099,
-0.021964077,
0.024842408,
-0.03179613,
0.026698526,
0.001948589,
0.009011594,
-0.006281215,
0.021318471,
-0.010053979,
-0.014337849,
0.036153976,
-0.007612779,
-0.008614814,
0.005870986,
0.024882758,
0.0032599776,
0.010027079,
0.002081409,
0.017955936,
-0.003142289,
-0.02412955,
-0.06509867,
0.0072698,
-0.0015106188,
0.009455448,
0.008117159,
-0.017041327,
0.014095746,
0.0070209727,
0.009381472,
0.01930095,
-0.019892756,
-0.00022276794,
-0.002067959,
0.012192551,
-0.032280333,
-0.027303783,
0.045945678,
-0.010645785,
0.031096723,
0.02316114,
-0.017660033,
0.004684011,
-0.0008381118,
0.012851608,
-0.012179101,
0.00022865237,
-0.011251042,
0.03190373,
-0.007532078,
-0.013355988,
0.006745245,
-0.035427667,
-0.0096303,
-0.0049967268,
-0.009946378,
-0.022824887,
0.004135918,
0.021802677,
0.009320946,
0.03174233,
-0.0191799,
-0.025904968,
0.0044486336,
0.020403862,
0.012851608,
-0.0028682423,
-0.029940011,
0.00056868873,
-0.0058070975,
-0.019139549,
0.0129793845,
0.0061332635,
0.0052590044,
-0.0136451665,
-0.018803295,
-0.0070276977,
-0.010565084,
-0.033033542,
-0.020995667,
-0.035884973,
0.0049462887,
0.016920276,
0.007713655,
0.005726397,
0.016705073,
0.009576499,
-0.022596234,
0.014768253,
0.024344752,
-0.026268123,
-0.030962221,
0.0065031424,
0.008399612,
0.00003233813,
-0.00039846037,
-0.020484563,
-0.03566977,
0.0035508368,
-0.021937177,
0.008049908,
0.013443414,
-0.002067959,
-0.020659413,
0.027128931,
0.0014811966,
-0.0099060275,
0.0013374483,
0.009986728,
0.025582165,
0.0046873735,
0.002099903,
0.026187422,
0.005551545,
0.011916824,
0.016987527,
0.036342278,
-0.0050068144,
-0.02228688,
-0.00094150973,
0.04920061,
0.0047243615,
0.016274668,
0.0058373604,
-0.0008477791,
-0.010417133,
0.035938773,
-0.016758874,
-0.02700788,
0.006684719,
-0.015602162,
0.013692242,
-0.00017474673,
0.0007939785,
0.003175914,
-0.023604995,
-0.009132645,
0.0040888423,
-0.0289716,
-0.014714452,
0.025151761,
0.015898066,
0.010040529,
0.005373331,
-0.006193789,
0.021439523,
0.013113886,
0.03179613,
-0.013893994,
0.027707288,
-0.026496775,
-0.0026244584,
-0.005719672,
-0.019717904,
-0.007895232,
-0.0029254053,
-0.019448902,
-0.017982837,
0.0041594557,
-0.023376342,
0.082906656,
0.01642262,
-0.030020712,
-0.019045398,
-0.013214762,
0.024465803,
-0.0074581024,
0.0010810549,
-0.024143001,
-0.021614375,
0.0119908,
-0.03297974,
-0.0033053719,
-0.049873117,
-0.013564466,
0.001778781,
-0.016180517,
0.021116719,
0.0070276977,
-0.01639572,
0.014270598,
-0.022381032,
0.0021436159,
0.022058228,
-0.02320149,
0.001156712,
0.04123813,
-0.008903992,
0.014149547,
-0.027505536,
-0.0012979384,
0.003022919,
-0.018520841,
-0.0030346876,
-0.0013256794,
0.004556235,
-0.006745245,
-0.0071890997,
0.011869748,
0.030343514,
0.007854882,
0.012723831,
-0.017135477,
-0.0071689244,
0.012374128,
-0.016718524,
-0.027182732,
-0.018978147,
-0.00036420455
] |
Although genetic association studies have been with us for many years, even for the simplest analyses there is little consensus on the most appropriate statistical procedures. Here I give an overview of statistical approaches to population association studies, including preliminary analyses (Hardy–Weinberg equilibrium testing, inference of phase and missing data, and SNP tagging), and single-SNP and multipoint tests for association. My goal is to outline the key methods with a brief discussion of problems (population structure and multiple testing), avenues for solutions and some ongoing developments. | [
-0.0077477973,
0.032117665,
0.02162572,
-0.039138492,
-0.035549488,
0.011199268,
0.011454689,
0.024297826,
-0.027847534,
-0.02433712,
-0.01045265,
-0.006293857,
0.004715481,
0.0042210105,
0.01890122,
-0.00040523664,
0.04877903,
-0.013766585,
0.015469397,
0.0036119274,
-0.036754552,
0.014932356,
-0.0051804795,
-0.0068505458,
0.0015480858,
0.044089746,
0.02779514,
-0.007322094,
-0.011402295,
-0.014565596,
0.018875021,
-0.015233623,
-0.009607792,
-0.020368258,
-0.022843886,
-0.031829495,
0.0020712095,
-0.006706462,
-0.0016782527,
-0.016517282,
0.00041669788,
0.014041654,
-0.010118636,
-0.025974441,
0.022319943,
0.002103956,
0.0009463708,
-0.0082127955,
-0.009234483,
0.013884472,
-0.016766155,
0.0021498008,
-0.047835935,
-0.006837447,
-0.001776492,
0.011697012,
0.008127655,
0.017931925,
-0.009968002,
-0.010983141,
-0.013609402,
-0.00018655212,
-0.03533991,
0.005504669,
-0.020735018,
-0.022817688,
-0.00080760795,
0.013687993,
-0.0024494303,
0.028685842,
0.018888121,
0.01380588,
-0.011703562,
0.018089108,
0.030834006,
-0.01307891,
0.010334763,
0.00059230044,
-0.015652778,
0.01007934,
0.003942666,
0.0019271254,
0.013792782,
0.0032713648,
-0.0055308663,
-0.0052721696,
0.0026590072,
0.020001499,
-0.01598024,
-0.024127545,
-0.017552068,
0.01017758,
-0.015783763,
-0.0008530436,
-0.019163191,
0.017237702,
-0.0055374154,
0.02334163,
0.0081735,
0.016242212,
-0.010747367,
-0.008016317,
-0.00001656507,
0.0018452593,
-0.008166951,
0.009090399,
-0.0019418612,
-0.0066475184,
-0.011159971,
0.022424731,
-0.0089594135,
0.015587284,
0.0025951518,
-0.00033626455,
0.024730077,
-0.013635599,
0.02217586,
-0.00917554,
-0.018586854,
-0.0030912596,
0.030650625,
-0.01062948,
0.042570315,
-0.0063167796,
0.024114445,
0.0128169395,
-0.044115942,
-0.014840666,
-0.005350761,
-0.020761214,
-0.0047122063,
0.014866863,
-0.000033616223,
0.021678114,
-0.033479914,
-0.014604893,
0.011435041,
-0.007957374,
-0.021088678,
-0.04133905,
0.012928277,
0.017316293,
-0.008468218,
-0.026092328,
0.010819409,
0.039112296,
0.030021895,
0.011605322,
-0.007944276,
-0.010616382,
0.0028505737,
0.007276249,
0.022044873,
0.01171666,
-0.008153852,
0.008703992,
-0.0063986457,
0.019936005,
-0.03696413,
-0.013295037,
0.0010732631,
-0.0001527824,
-0.00917554,
0.013832077,
0.00032152867,
0.02879063,
-0.0037363637,
-0.02280459,
0.016202915,
-0.025699371,
-0.017093617,
0.024179937,
-0.034213435,
0.01671376,
0.007773994,
-0.007459629,
0.0073351925,
0.011304055,
-0.008363429,
-0.037016526,
0.012188208,
0.010315115,
0.032563016,
0.01862615,
-0.008317584,
-0.0021105052,
0.025542188,
0.025699371,
0.0052295993,
-0.020381356,
0.013543909,
0.0064084698,
-0.010773564,
-0.00080228667,
-0.63962877,
-0.0031059955,
-0.025502892,
-0.023734586,
0.022372337,
0.017329393,
0.019019106,
-0.004476432,
-0.003605378,
0.05658577,
-0.01045265,
0.022450928,
0.018835727,
-0.025188528,
-0.036754552,
-0.041181866,
0.013301586,
-0.04571397,
0.023027265,
-0.0039917855,
-0.056795347,
0.03368949,
0.0064117443,
0.021481635,
0.014238132,
0.014565596,
0.008887372,
0.015155031,
-0.008789132,
0.018468967,
-0.015561087,
0.012273349,
-0.020001499,
0.0172508,
0.035130333,
-0.004054004,
0.0056618517,
0.031829495,
0.0199753,
0.036911737,
-0.02879063,
-0.025306415,
0.018508263,
0.013216445,
-0.009601243,
0.01971333,
-0.005606183,
0.018311784,
0.006876743,
-0.034318224,
-0.003533336,
0.014342921,
-0.011762505,
-0.013936866,
0.010040045,
-0.005550514,
0.015128834,
-0.02115417,
0.0005562794,
0.010793212,
-0.009738778,
-0.004263581,
0.011192718,
-0.008016317,
-0.0154432,
0.012057222,
-0.0055701616,
0.01090455,
0.0007122341,
-0.008304486,
0.0036021036,
0.042360738,
-0.016818548,
-0.007322094,
0.021678114,
0.020420652,
-0.006103928,
0.029602742,
-0.010780113,
0.0023020715,
-0.008016317,
-0.001241907,
-0.014866863,
-0.008330683,
0.025188528,
0.0010216875,
-0.0147358775,
0.008049064,
-0.012568067,
-0.002755609,
-0.006051534,
0.0024592543,
0.003338495,
-0.036099628,
-0.006909489,
0.016857844,
-0.0006790784,
0.0035955543,
0.0046991077,
-0.043644395,
-0.025830356,
-0.016844746,
0.001605392,
0.0015071528,
0.018298686,
0.015024046,
0.019503754,
-0.009273779,
0.032327242,
0.008343781,
0.0172508,
-0.003939391,
-0.0036675963,
-0.019006008,
0.0058190343,
-0.032667805,
-0.018468967,
0.0031649391,
-0.015063342,
-0.031279355,
0.036937933,
0.026825847,
0.014473907,
-0.030152882,
0.0036806948,
0.008618851,
-0.017460378,
-0.0018157876,
-0.0005268076,
-0.016556578,
-0.002144889,
-0.0136225,
0.022739097,
0.00028530296,
-0.0074530793,
-0.033558507,
-0.005396606,
-0.00049160526,
-0.012653207,
-0.023302335,
-0.0058616046,
0.0026147997,
0.010092439,
-0.01008589,
-0.023105856,
-0.033008367,
-0.021101777,
-0.014801371,
0.0048497412,
-0.009051104,
0.010007299,
-0.013046164,
-0.0027408733,
0.026747255,
-0.006870194,
0.0035038642,
0.005154283,
-0.018403474,
-0.019136993,
-0.0064051948,
0.010256171,
0.0036446739,
-0.022817688,
-0.00043143376,
-0.01435602,
-0.011454689,
-0.021835295,
-0.011513633,
-0.017237702,
-0.014906159,
0.027087819,
-0.019032205,
-0.0070601227,
0.014670385,
-0.02008009,
-0.00095783203,
-0.0082258945,
-0.013543909,
-0.008343781,
-0.030152882,
-0.0019565972,
-0.026511481,
-0.022843886,
-0.0036806948,
0.04657847,
0.01870474,
-0.0015431739,
-0.012384687,
0.023328532,
0.009922158,
0.0007531671,
0.0128103895,
-0.013281938,
0.018285587,
0.01380588,
0.01890122,
-0.0058059357,
0.0070928694,
0.0015587284,
0.039138492,
0.028685842,
-0.009817369,
-0.009863215,
-0.026904438,
0.028921615,
-0.03659737,
0.0113302525,
-0.017971221,
0.006732659,
0.006657342,
0.0012181659,
-0.017512772,
-0.029235981,
-0.02234614,
0.0038215043,
0.02125896,
-0.020787412,
0.00608428,
0.005380233,
0.02190079,
0.013098558,
0.004787523,
0.035523288,
-0.008363429,
-0.029497953,
-0.023773883,
0.029681332,
0.032274846,
0.0035857302,
-0.005432627,
-0.016504183,
0.005298367,
0.0032140587,
0.00044780696,
0.019818118,
-0.0020826708,
-0.0012525496,
-0.017303195,
0.011762505,
0.0029553622,
-0.018495165,
0.0014310174,
0.01607193,
-0.00032848728,
0.02653768,
0.0020548364,
0.02670796,
0.014906159,
-0.01917629,
0.022306845,
0.01081286,
0.0010577085,
-0.010341312,
0.01607193,
-0.00084813166,
-0.034658786,
-0.0037363637,
0.008468218,
0.04657847,
0.027952323,
0.0068570953,
-0.016281508,
-0.007819839,
-0.015128834,
-0.002924253,
0.005249247,
-0.005268895,
-0.009326173,
-0.017499674,
0.0060908296,
-0.016058832,
-0.017552068,
0.0003868168,
-0.008789132,
0.026092328,
0.0047449525,
0.024297826,
0.01516813,
0.027664155,
-0.011546379,
-0.023538109,
0.000847313,
0.021992479,
0.022188958,
-0.021848395,
-0.017931925,
0.03099119,
-0.0065361806,
-0.031567525,
-0.005760091,
0.00224804,
-0.00320096,
0.008743287,
-0.011788703,
0.00899216,
-0.002262776,
0.026930636,
-0.0031256434,
0.01516813,
-0.010341312,
0.005697873,
0.0011829635,
-0.015194328,
-0.0092606805,
0.02161262,
-0.0039459406,
-0.013674894,
-0.019398965,
-0.0005837045,
-0.0028947813,
0.015652778,
-0.013504613,
-0.009633989,
0.01280384,
0.015639678,
-0.0017732173,
-0.022516422,
0.030257668,
0.04312045,
-0.0027621584,
0.0015268007,
-0.043644395,
-0.020027695,
0.014395315,
0.07570966,
0.018455869,
-0.01380588,
0.016753055,
0.0033270337,
0.015652778,
-0.00449608,
-0.036754552,
0.02252952,
-0.004708932,
-0.024769373,
0.021088678,
0.023590503,
0.017093617,
0.01653038,
0.034108646,
-0.009470258,
-0.022110365,
-0.0021989204,
0.010544339,
-0.014539399,
-0.020381356,
0.021376846,
0.0399506,
0.02607923,
-0.006496885,
0.005412979,
0.014041654,
-0.000090206086,
-0.015639678,
-0.02398346,
0.012928277,
-0.0037527368,
0.022044873,
-0.009561948,
0.018062912,
0.015377707,
-0.0037527368,
0.0044076648,
-0.015744466,
0.018482065,
0.007675755,
0.009463708,
0.013281938,
-0.00044207633,
0.001566915,
0.030205274,
0.01199173,
0.012731798,
-0.000880878,
0.007846036,
-0.014919258,
0.0010454287,
-0.0172508,
0.008180049,
0.0021432515,
0.0024003107,
-0.011500534,
-0.000090206086,
-0.01943826,
-0.030074289,
-0.016779253,
0.018220095,
0.0070601227,
-0.008717091,
-0.029183587,
-0.028371477,
-0.027035424,
-0.03735709,
-0.012423982,
0.0058157598,
-0.021848395,
-0.02170431,
-0.026694862,
0.03685934,
0.012712151,
0.007977022,
0.0045550237,
-0.005760091,
0.025280217,
-0.031567525,
-0.01671376,
-0.021468537,
-0.039845813,
0.0024969126,
0.020381356,
-0.02871204,
0.024402613,
-0.018364178,
0.026498383,
-0.0038444267,
0.0024690782,
-0.008527162,
-0.023577405,
0.003174763,
0.029052602,
0.002703215,
0.004060553,
-0.001848534,
-0.006631145,
0.00043880168,
-0.027218804,
-0.0129610235,
-0.033165548,
-0.002524747,
-0.0052459724,
-0.021272058,
0.00998765,
-0.0046467134,
-0.014054753,
0.011965533,
-0.041181866,
0.018036714,
0.016831648,
0.02260811,
0.04225595,
0.0021890965,
0.031829495,
0.023001067,
-0.017604463,
-0.0023921242,
0.011402295,
0.01045265,
0.0028178273,
-0.033008367,
0.014945455,
-0.02889542,
-0.02170431,
-0.02698303,
0.005743718,
-0.020538539,
0.0354185,
-0.007859135,
-0.017669955,
-0.024638388,
0.013092008,
-0.014971652,
0.0018108756,
-0.0054555493,
-0.01353081,
0.01917629,
0.0009381842,
0.012378138,
-0.017421082,
0.025267119,
-0.027821338,
-0.016792351,
0.00953575,
-0.030388655,
0.013098558,
0.008920118,
-0.023826277,
-0.0012779281,
-0.015927847,
-0.0010994602,
-0.021494733,
-0.0027523346,
0.0015767389,
0.024127545,
-0.00012464097,
0.020263469,
-0.0058124852,
0.01307891,
0.024716979,
-0.011592224,
-0.0052721696,
-0.010328213,
-0.00899871,
-0.0052165007,
0.016320804,
0.019294176,
0.002750697,
0.012103068,
0.007047024,
0.03560188,
0.021756705,
-0.0013753485,
-0.033191748,
-0.011873843,
-0.03151513,
-0.0038182298,
0.007603713,
-0.016962633,
0.020119386,
-0.028816829,
0.014395315,
0.017787842,
-0.008428922,
-0.0095553985,
0.01290208,
0.023773883,
0.0014277429,
0.028450068,
-0.01607193,
0.013936866,
-0.028319083,
-0.02716641,
-0.036728356,
0.012017927,
0.02926218,
-0.0076102624,
0.028581053,
-0.005648753,
-0.005114987,
-0.012751446,
-0.0018092383,
-0.039269477,
-0.0012975759,
0.008703992,
-0.009005259,
0.007250052,
-0.017276999,
0.012063772,
0.002212019,
0.012044124,
-0.0145917935,
0.0028178273,
-0.0063266037,
-0.033584703,
-0.015076441,
0.008756386,
-0.002293885,
0.0056356546,
0.0052165007,
0.027245,
0.006061358,
0.0018861924,
-0.04613312,
0.002144889,
0.010917648,
0.020839807,
0.01262046,
0.011376098,
-0.015233623,
-0.017486574,
0.0114743365,
-0.006166146,
-0.014303626,
-0.04715481,
0.018652346,
0.008487865,
0.0053212894,
-0.025673173,
0.017499674,
-0.026105426,
0.020879101,
-0.005596359,
-0.0042373836,
-0.004214461,
-0.025948243,
0.0075382204,
0.018364178,
0.020551637,
0.009332723,
-0.003083073,
-0.023092758,
-0.0042013624,
-0.0048562903,
-0.006002414,
-0.0005890258,
0.0067719547,
0.03379428,
-0.0053180144,
0.008147303,
0.01280384,
0.014225034,
-0.012757995,
0.0015325313,
-0.026393594,
0.0390599,
-0.02508374,
-0.017552068,
-0.009640539,
0.009738778,
0.007413784,
0.00835033,
-0.022450928,
-0.040736515,
0.0035726316,
-0.0027785315,
0.023577405,
0.004230834,
0.013884472,
-0.0064117443,
-0.008599203,
0.010721169,
-0.0024690782,
-0.04016018,
0.00440439,
-0.027873732,
-0.002544395,
-0.025502892,
-0.016150523,
0.02162572,
0.023367828,
0.0033090233,
-0.010563987,
0.01408095,
-0.013150952,
0.031672314,
0.011467787,
0.0017404709,
-0.007983571,
0.016517282,
-0.038090605,
-0.007413784,
0.010059693,
-0.0015873815,
-0.01080631,
-0.027087819,
0.019922907,
0.02652458,
0.004961079,
0.002811278,
-0.006123576,
0.015128834,
0.021586424,
-0.00040748797,
-0.0318033,
0.012155462,
0.0018829177,
-0.0014400227,
0.024232332,
-0.013072361,
0.030126683,
-0.00531474,
-0.00087187276,
-0.0019762449,
-0.017787842,
-0.017512772,
-0.023852475,
0.02480867,
-0.010563987,
0.02497895,
-0.0021694486,
-0.013871373,
0.008985611,
0.025856555,
-0.0023315432,
-0.004060553,
-0.008586105,
0.021835295,
0.012253701,
0.014198837,
-0.016923336,
0.00079614675,
-0.00152107,
0.003742913,
-0.026642468,
0.010577085,
-0.010839057,
0.02941936,
0.035182726,
-0.006031886,
-0.012869333,
0.0019189387,
-0.027559366,
-0.030807808,
-0.019739527,
-0.0005182117,
0.0122209545,
0.031855695,
-0.00002778327,
0.04285848,
0.011042085,
-0.014460808,
-0.038378775,
0.0060155126,
-0.0069160387,
-0.0067916024,
0.017761644,
0.023328532,
-0.02753317,
0.0021105052,
0.022057971,
-0.005023297,
-0.021926986,
0.0063724485,
0.00041710722,
0.031567525,
-0.0077216,
0.014932356,
0.013288487,
0.002642634,
0.018822627,
-0.013177149,
-0.017015027,
0.0022791491,
-0.010315115,
-0.0133998245,
0.005940196,
-0.0004306151,
-0.010302016,
0.003834603,
-0.031226963,
-0.015521791,
-0.00367742,
0.00762991,
-0.008736738,
0.009738778,
-0.011873843,
0.012391236,
-0.0104395505,
-0.008893921,
0.010465748,
-0.013740388,
-0.0022676878,
-0.0041194963,
-0.011461238,
-0.012528771,
-0.0057469923,
-0.0076102624,
-0.0010585273,
0.02044685,
-0.02433712,
0.0018927417,
-0.017159112,
-0.020813609,
0.027899928,
0.011520182,
0.006621321,
0.015587284,
-0.019228684,
-0.04160102,
0.021940084,
-0.0045910445,
0.0026508207,
-0.03740948,
0.027192606,
0.003497315,
-0.010701522,
0.0006889023,
-0.004715481,
-0.022974871,
-0.011349901,
0.024782471,
0.2007747,
-0.02135065,
-0.0047547766,
0.027742745,
0.02025037,
-0.023931066,
0.019320372,
0.01862615,
0.02580416,
-0.0023413673,
0.020564737,
-0.0032189707,
-0.032589212,
0.0075447694,
0.03680695,
-0.027899928,
-0.023420222,
-0.019425161,
-0.011795252,
0.010675325,
0.021376846,
-0.004839917,
-0.021861494,
-0.011146873,
0.033479914,
-0.007584065,
-0.03235344,
-0.010164481,
-0.0045648473,
0.0070339255,
-0.0181546,
0.00844857,
0.013635599,
-0.00024334664,
-0.02678655,
0.00120343,
0.032772593,
-0.0003241893,
0.012908629,
-0.010550888,
0.0015358059,
0.0044011157,
-0.017067421,
-0.013321234,
0.009463708,
-0.0045026294,
-0.0029062426,
0.018455869,
-0.014945455,
-0.00762991,
-0.05113677,
-0.010609832,
0.0019500478,
0.017381787,
-0.017316293,
-0.002310258,
0.0107408175,
0.013543909,
-0.00322552,
0.0236167,
-0.008415824,
-0.002058111,
-0.012685954,
0.015207426,
-0.02161262,
0.024179937,
-0.0076168114,
0.019674035,
0.0027605211,
-0.00046950145,
0.0036086529,
-0.024035854,
-0.009437511,
-0.009778074,
-0.023092758,
-0.014906159,
0.045792557,
0.015403904,
0.018193897,
-0.002233304,
-0.011225464,
0.015613481,
-0.028581053,
0.0024739902,
-0.037016526,
-0.02243783,
0.03169851,
-0.0086646965,
-0.01081286,
-0.0034842165,
-0.008795681,
0.021311354,
-0.006562378,
-0.020394456,
-0.000052905896,
0.009306526,
0.004833368,
0.008291387,
-0.0057338937,
-0.00027015776,
-0.01525982,
0.060515337,
0.012004828,
0.013393275,
0.0054490003,
0.01180835,
-0.02080051,
0.008487865,
-0.0029471756,
0.014696582,
0.013203346,
-0.039138492,
0.011408844,
-0.010603283,
0.0005141184,
0.010171031,
0.0017945025,
-0.05006269,
0.008618851,
-0.010347861,
-0.008841527,
-0.012875883,
0.011074831,
0.025476696,
0.0090773,
0.012548419,
0.0042570313,
-0.011022436,
0.0011354813,
-0.018560657,
0.017015027,
0.0058943513,
-0.024389515,
0.0016479624,
0.013013418,
-0.023642898,
-0.012784192,
-0.023446418,
-0.019019106,
0.007492375,
0.022450928,
-0.0070273764,
-0.017237702,
0.02706162,
0.007014278,
-0.020826707,
0.019202486,
0.0033139351,
0.0014973289,
0.011690463,
-0.009051104,
0.008094909,
0.01171666,
-0.010374058,
-0.009286878,
-0.025843455,
-0.008022867,
-0.028554857,
0.027821338,
0.014107147,
-0.008022867,
0.029786121,
0.04516383,
0.0034023505,
0.007256601,
0.0010405167,
-0.16399394,
0.007773994,
0.012240603,
0.0141464425,
0.01798432,
0.040291164,
0.017276999,
0.004296327,
0.012646657,
-0.0017306469,
0.0044567846,
0.0026753806,
0.0061792447,
-0.017434182,
0.0019140268,
0.00990251,
0.0010118636,
0.026852043,
0.013019967,
0.008343781,
0.016595874,
-0.020459948,
0.014094048,
-0.014277428,
0.020001499,
0.03033626,
0.0101448335,
0.020499242,
-0.045373406,
-0.023053462,
-0.018115306,
0.0003931614,
0.0059631187,
-0.022398535,
-0.019058403,
0.006830898,
0.008324133,
-0.009837017,
0.006349526,
0.004198088,
0.03769765,
0.035916246,
-0.0024641661,
-0.006392096,
-0.0068243486,
0.01117307,
0.025398104,
-0.007151813,
0.041077077,
-0.010819409,
-0.0018059637,
-0.004489531,
0.02497895,
0.024481205,
0.019818118,
0.0038378774,
-0.0063986457,
0.009385116,
-0.0031583898,
-0.014814469,
-0.0048562903,
-0.018914318,
0.012685954,
0.008081811,
0.0072173057,
-0.021180369,
-0.027664155,
0.017945025,
-0.021494733,
0.00899871,
-0.002912792,
0.008880822,
-0.0027670704,
-0.02579106,
0.017276999,
0.006660617,
-0.0066999123,
0.0009324536,
0.0153253125,
-0.0094047645,
-0.0014604892,
0.022817688,
0.002269325,
-0.016137423,
-0.0003043368,
-0.0037396383,
0.01735559,
0.016569676,
-0.008022867,
-0.006028611,
0.0345016,
-0.01671376,
0.00029758285,
-0.03306076,
0.02716641,
0.0090773,
-0.016347,
-0.005232874,
0.01971333,
-0.011042085,
-0.0046401643,
-0.0028849575,
-0.011998279,
0.005380233,
0.032824986,
-0.025175428,
-0.002115417,
-0.0013327783,
0.01697573,
0.0037953071,
-0.014198837,
0.0036872441,
0.009496454,
0.008841527,
-0.009660186,
0.041915387,
-0.013884472,
-0.020145582,
-0.021206565,
0.0025181978,
0.054018453,
-0.012194757,
0.016831648,
0.0045026294,
-0.0012288084,
-0.018639248,
-0.121135466,
-0.012325743,
-0.00072492333,
-0.005511218,
0.0014670385,
0.018311784,
-0.027218804,
0.01653038,
-0.019281078,
0.045294814,
-0.011723209,
-0.016517282,
-0.022660505,
-0.010112087,
-0.0004940612,
-0.00027384172,
-0.0037592861,
-0.012011378,
-0.011140323,
0.02753317,
-0.008186599,
-0.023944164,
-0.0029782846,
-0.007911529,
-0.020302765,
0.012148913,
-0.020944593,
0.041286655,
-0.0048497412,
0.012404335,
-0.013393275,
-0.015521791,
-0.0022414906,
-0.019516852,
-0.021940084,
-0.015010947,
-0.00789843,
-0.035837654,
0.021743607,
0.010727719,
-0.008422373,
0.025005147,
0.01972643,
0.00095455744,
0.003798582,
-0.004024532,
-0.007773994,
0.035732865,
-0.0009995837,
-0.0060089636,
0.012201306,
-0.010636029,
-0.014696582,
-0.0018567207,
-0.022595013,
0.0039655883,
-0.006241463,
0.00053090096,
-0.0043127,
0.013242642,
-0.025214724,
0.0047122063,
-0.016085029,
0.0148799615,
0.0016782527,
-0.003138742,
-0.01689714,
-0.013871373,
0.019032205,
-0.025581485,
-0.025031345,
0.010328213,
-0.011048634,
0.000761763,
-0.028083308,
0.000020773494,
-0.03654498,
-0.006215266,
0.031017385,
-0.019320372,
-0.011114126,
-0.014945455,
0.02588275,
-0.029628938,
0.023105856,
0.0040278067,
-0.022843886,
-0.0017208231,
0.0009250857,
-0.015888551,
-0.005367134,
0.032484423,
0.001636501,
-0.008933216,
-0.019385867,
0.004460059,
-0.017211506,
-0.022739097,
0.017971221,
0.014906159,
-0.03869314,
0.0042210105,
-0.03924328,
0.02508374,
0.012843136,
-0.03489456,
-0.014893061,
0.0028096407,
0.0057011475,
0.004885762,
-0.004987276,
0.0021285156,
-0.023839375,
0.01653038,
-0.009430962,
-0.02643289,
-0.017015027,
-0.02025037,
0.018730938,
-0.0046827346,
0.03934807,
0.024193037,
0.0013982711,
0.0036446739,
0.025686271,
0.021141073,
0.0064051948,
-0.029314574,
0.019136993,
-0.009031456,
-0.013491515,
0.000010597808,
0.009575046,
-0.02779514,
-0.019267978,
0.015639678,
-0.01789263,
-0.03044105,
0.019202486,
0.017198406,
0.037933424,
0.044823267,
-0.021337552,
-0.0032631783,
-0.013046164,
-0.00039766403,
-0.024271628,
0.003661047,
-0.0209053,
0.015665876,
0.01444771,
-0.036728356,
0.022057971,
-0.000684809,
-0.007852586,
-0.02989091,
-0.013609402,
-0.004522277,
0.007675755,
0.0131706,
0.00313383,
-0.040081587,
0.034134842,
0.012325743,
0.013373627,
0.015050244,
-0.016032634,
-0.0064117443,
0.0020466498,
0.02897401,
-0.007138714,
-0.016163621,
-0.016491085,
0.012286447,
0.0031256434,
-0.0101448335,
0.019359669,
-0.007983571,
0.0092541315,
0.01599334,
0.012987221,
0.016124325,
0.0044076648,
0.016058832,
-0.018599952,
0.03961004,
0.039714828,
-0.00690294,
-0.028764434,
0.017945025,
-0.013949964,
0.013334332,
-0.008121106,
0.017735448,
0.0000250075,
0.027349789,
0.0105901845,
0.026629368,
-0.008101458,
0.012358489,
0.033296533,
0.0043323482,
-0.020852905,
0.011742857,
-0.0081735,
-0.022293746,
-0.029681332,
-0.008402725,
-0.021665014,
-0.019922907,
0.0015128835,
0.017329393,
0.013072361,
0.008199697,
-0.026904438,
-0.015574185,
0.011245112,
0.0007097781,
-0.002212019,
-0.008166951,
-0.006248012,
0.0013663433,
0.013052713,
0.009365469,
0.015705172,
0.020682624,
0.016595874,
0.007944276,
0.016962633,
-0.0122209545,
0.025136134,
-0.0065361806,
0.0077150506,
-0.004050729,
-0.0027670704,
0.006005689,
0.010013848,
0.0017371962,
0.0114743365,
-0.0092606805,
-0.030467246,
0.059991397,
0.012790742,
-0.010976592,
-0.005557063,
-0.0031911363,
0.014316724,
0.020368258,
-0.020473046,
-0.002192371,
-0.034632586,
0.01180835,
-0.02442881,
-0.007014278,
-0.026734157,
0.0082127955,
0.025057541,
-0.020459948,
0.0022300296,
-0.02834528,
-0.010753917,
0.014696582,
-0.0006831717,
0.025660075,
0.017905729,
-0.025293315,
-0.017263899,
0.04435172,
0.010891451,
0.016189817,
-0.030362457,
-0.00417844,
0.015888551,
-0.027218804,
-0.0086581465,
-0.010622931,
-0.0064182933,
0.007459629,
-0.013779683,
0.01307891,
-0.0053769583,
0.0024625289,
-0.0043912916,
-0.014303626,
-0.0148799615,
-0.01925488,
0.003798582,
-0.012122716,
-0.017263899,
0.00003678853
] |
Tripartite motif (TRIM) proteins constitute a family of over 100 members that share conserved tripartite motifs and exhibit diverse biological functions. Several TRIM proteins have been shown to restrict viral infections and regulate host cellular innate immune responses. In order to identify TRIM proteins that modulate the infection of hepatitis B virus (HBV), we tested 38 human TRIMs for their effects on HBV gene expression, capsid assembly and DNA synthesis in human hepatoma cells (HepG2). The study revealed that ectopic expression of 8 TRIM proteins in HepG2 cells potently reduced the amounts of | [
-0.03467109,
-0.0065982016,
-0.028201617,
-0.028201617,
-0.028861769,
0.025521407,
-0.027224595,
0.0127409,
0.0019210372,
-0.007360675,
0.0038486759,
-0.007875592,
-0.00049882603,
-0.0038783825,
-0.010489787,
0.01726953,
0.01651696,
-0.019936537,
-0.0015043173,
0.018074913,
-0.016939456,
-0.005093059,
-0.036413886,
-0.014404478,
-0.0052382923,
0.013064373,
0.021151213,
-0.038130276,
-0.010080494,
-0.015038222,
0.017177109,
-0.020728717,
-0.008456524,
0.024768837,
0.01212696,
0.0112951705,
0.006086585,
0.009268509,
0.017427966,
-0.00637045,
0.039001677,
0.013902764,
-0.015553139,
0.029653948,
-0.0077237575,
0.005660788,
0.02249792,
-0.013968779,
-0.032188926,
0.019738492,
0.0038849842,
0.013255817,
-0.020557078,
-0.015275876,
-0.020359034,
0.018748267,
0.0013970429,
0.001226229,
-0.006192209,
-0.018655846,
-0.007941607,
-0.000905231,
-0.021956597,
-0.003568112,
0.01124896,
0.013084178,
-0.006433164,
-0.00040310423,
0.0003379144,
0.023197679,
0.04029557,
0.015262674,
-0.010753848,
0.005027044,
0.017256327,
-0.020926762,
-0.030710189,
0.00037360378,
-0.0008111596,
0.016411334,
0.0045055253,
0.02574586,
0.00084004115,
-0.009090269,
0.024240715,
-0.008641367,
0.02970676,
0.01076705,
0.044943027,
-0.0053274124,
0.014047997,
0.011770478,
0.008185863,
0.009440148,
-0.031845648,
0.012047742,
-0.013770734,
0.031740025,
-0.0025415784,
0.0057499083,
-0.01072084,
0.010826464,
-0.01638493,
-0.0032099804,
-0.033852503,
0.0040368186,
-0.008905427,
-0.007730359,
0.01050299,
-0.024333138,
-0.024280325,
0.028597707,
-0.0075455173,
-0.04597286,
0.013295426,
0.026247572,
0.01881428,
0.0131832,
0.0060964874,
-0.009717411,
0.003097755,
0.03725888,
0.008496134,
-0.001863274,
0.015724778,
0.015619154,
-0.010582208,
-0.0048223976,
-0.0013219508,
-0.01015311,
0.02425392,
0.0092289,
-0.0028419467,
0.0067566377,
-0.002917864,
0.0012221031,
-0.037760593,
-0.007948209,
-0.020992776,
-0.0021025785,
0.02491407,
0.020636296,
-0.012377817,
0.000500889,
0.0017824057,
0.012826719,
0.040321976,
0.0051524723,
-0.001836868,
0.0016825579,
0.011638449,
-0.016728207,
0.028201617,
0.0039179916,
0.014153621,
0.02298643,
-0.006594901,
0.013203004,
-0.008687577,
-0.016992267,
-0.010819863,
-0.012087351,
0.015236267,
-0.0006618006,
0.021652928,
0.024583995,
-0.00988905,
0.011374389,
-0.0030862023,
-0.0047827885,
0.014219636,
0.0050600516,
-0.043939598,
-0.0034954955,
-0.016781019,
0.011539426,
0.013678312,
0.021600116,
-0.0027313717,
-0.02395025,
-0.010463381,
-0.0016660541,
0.020543875,
-0.0030944543,
-0.016371725,
-0.0065816976,
0.012806915,
-0.016437741,
0.023210881,
-0.02583828,
-0.004158946,
0.00011934278,
0.010602012,
-0.006792946,
-0.64008164,
-0.029469106,
0.013354839,
-0.015209861,
0.021243634,
0.025151724,
0.039265737,
-0.0037430518,
-0.024887664,
0.016028447,
-0.009195893,
-0.0023303302,
0.01445729,
-0.02772631,
0.00023971705,
-0.036836382,
-0.017348748,
-0.0061096903,
0.0030251385,
-0.0034063752,
-0.023171272,
-0.0138895605,
0.0069975923,
0.020662703,
0.005594773,
0.013863155,
0.010331351,
-0.025191333,
-0.008529141,
0.028544895,
-0.022458311,
0.022299875,
0.009657998,
0.0071824347,
0.053155296,
0.008647968,
-0.009261908,
0.01858983,
0.01726953,
0.026036326,
0.013625501,
-0.010027682,
0.019580055,
0.006604803,
0.007413487,
0.028967392,
0.021230431,
0.0076181334,
0.011902508,
0.0095853815,
-0.0029211647,
0.010925487,
-0.013361441,
-0.024729228,
0.023739003,
-0.0036275254,
0.031211903,
-0.027356625,
0.007987818,
0.0004130065,
-0.0069975923,
0.012536253,
-0.005786217,
-0.0087998025,
-0.0084235165,
0.010905682,
-0.010199321,
0.013704719,
0.0020976274,
-0.0075917277,
0.0049379235,
0.038605586,
0.012100554,
-0.0060799834,
0.00602057,
0.0496697,
0.01985732,
0.005013841,
0.00562448,
0.020728717,
0.019342402,
0.0007901173,
-0.022167845,
-0.023540957,
0.009809832,
-0.005730104,
-0.005997465,
0.029997226,
-0.0021999506,
0.01445729,
0.028360054,
-0.000053121465,
-0.00045839182,
-0.00063828274,
-0.024689618,
0.0087998025,
-0.023897437,
-0.00016441867,
-0.008746991,
-0.00035008593,
-0.0006556117,
-0.0334036,
0.018022101,
-0.002566334,
-0.0016148925,
-0.017626012,
-0.0060964874,
0.005703698,
0.049247205,
-0.0063605476,
0.0093807345,
0.0027528265,
0.0030630971,
-0.0016792571,
-0.003957601,
-0.01868225,
0.011783682,
0.01155923,
-0.005839029,
-0.03773419,
0.006446367,
-0.022999633,
0.0017394959,
0.013110584,
0.008449923,
0.019712085,
-0.0023253793,
-0.022194251,
-0.011182945,
0.0011684659,
0.016292507,
0.009169486,
0.035225615,
-0.019764898,
0.04169509,
0.009631592,
0.0025333264,
0.016186884,
-0.011083922,
-0.031607993,
-0.007829382,
-0.024240715,
-0.004779488,
-0.0023319807,
-0.02587789,
-0.013143591,
0.00412924,
0.0021372363,
0.026353197,
0.00048809857,
0.019144356,
0.02451798,
0.016147275,
-0.015051425,
0.015302282,
-0.013915967,
-0.012879531,
-0.035753738,
-0.0029343679,
-0.005129367,
-0.0062516225,
0.015817199,
-0.004961029,
-0.002209853,
-0.008284885,
-0.016279304,
0.014153621,
-0.017441168,
0.002653804,
-0.037522938,
0.03147596,
-0.021903785,
-0.029812384,
0.0113281775,
-0.03036691,
0.026207965,
-0.0027099168,
-0.005304307,
-0.00817266,
0.0026901122,
-0.009123276,
-0.01577759,
-0.032320954,
-0.014008388,
0.03348282,
0.006578397,
0.034961555,
0.02280159,
0.033165947,
0.02030622,
-0.010258734,
-0.0068523595,
0.004152345,
0.019830912,
0.00755872,
-0.003330458,
0.023884235,
0.01296535,
-0.009591983,
0.015196659,
0.026656866,
-0.021032386,
-0.00067170284,
-0.03063097,
0.008317892,
-0.007400284,
-0.009506163,
-0.01564556,
-0.014549711,
0.0010026032,
-0.004076428,
-0.006433164,
-0.023276897,
0.002500319,
-0.009090269,
0.0007220393,
-0.012503245,
0.002315477,
-0.02272237,
-0.032901887,
0.013942373,
-0.014206433,
0.012034538,
-0.006070081,
-0.011935516,
0.00018009724,
-0.01300496,
0.011605441,
-0.005129367,
-0.028888173,
-0.004069826,
0.0061889086,
0.0059380513,
0.013255817,
0.010205923,
0.011612043,
-0.0014952403,
-0.020134581,
0.03673076,
-0.00676654,
-0.0014341763,
0.014114012,
-0.0048422017,
-0.02179816,
0.020596687,
-0.014246042,
0.02425392,
-0.005069954,
0.009941862,
0.028122399,
-0.011869501,
0.017375154,
-0.036149826,
-0.0062780287,
0.022563934,
-0.019896928,
-0.0004183702,
0.010978298,
0.050910786,
0.012958749,
0.02030622,
-0.010179517,
0.017427966,
-0.022524325,
0.028703332,
0.008284885,
0.005017142,
-0.012721095,
-0.011057517,
0.006363848,
-0.0011115279,
-0.005489149,
0.022643153,
-0.023092056,
0.008925231,
0.016635785,
0.007321066,
0.0020316122,
-0.018312568,
0.025587423,
-0.02355416,
-0.044705372,
0.007895397,
0.016781019,
-0.016424539,
-0.02851849,
-0.044969432,
-0.028333647,
0.011572434,
0.008760193,
-0.002698364,
0.0013425805,
0.005353818,
0.017031876,
0.005159074,
-0.01169126,
0.013136989,
-0.016094463,
0.003147266,
-0.014285651,
-0.00011088461,
-0.011717667,
-0.020702312,
-0.017282734,
0.010040885,
0.013783936,
-0.004059924,
0.0016553267,
0.008007622,
-0.0044758185,
0.014576117,
-0.034565467,
0.001704838,
-0.016754612,
0.012008132,
0.013981982,
-0.010377562,
0.02280159,
0.0045682397,
0.0045814426,
-0.0184578,
-0.02253753,
-0.01045678,
0.015447515,
0.019923333,
0.018537018,
0.010384163,
0.034776714,
0.024240715,
0.015988838,
0.005343916,
-0.031660806,
0.022075424,
-0.013282223,
-0.005324112,
-0.021019183,
-0.0019441424,
0.015038222,
0.0035912173,
0.02189058,
0.008370705,
-0.016754612,
-0.0103379525,
0.011235757,
0.0111565385,
-0.0038321721,
0.009968269,
0.026339995,
0.016926251,
-0.009988073,
0.011176343,
0.03242658,
0.0046474575,
-0.02179816,
0.016054854,
-0.012278794,
-0.023461739,
0.016596178,
0.0077237575,
-0.039952293,
0.017388357,
0.01955365,
0.015922824,
0.015447515,
-0.0030548451,
0.0010537648,
-0.006033773,
-0.018114522,
-0.0066378107,
-0.008284885,
-0.03348282,
-0.00086232123,
0.011796884,
-0.01726953,
0.0153815,
0.01045678,
0.010958494,
-0.037417315,
-0.0149854105,
-0.02412189,
-0.01810132,
-0.0023913942,
0.010483186,
-0.04507506,
-0.011130133,
-0.030076444,
0.014959004,
-0.0052316906,
-0.0028419467,
-0.020372236,
-0.017348748,
-0.027488656,
-0.0068787653,
-0.004406503,
0.016107665,
-0.035542488,
-0.018114522,
0.008753592,
-0.013955575,
0.008238675,
0.014404478,
-0.03916011,
0.027171783,
0.002698364,
-0.02175855,
-0.025455393,
0.010615216,
-0.038024653,
0.004406503,
0.0010389114,
-0.010423772,
-0.008885622,
-0.0067434344,
0.0017147402,
0.016675394,
-0.004389999,
0.009657998,
0.0051524723,
-0.012140162,
0.027647091,
0.02127004,
0.013638704,
-0.004736578,
-0.0068127504,
-0.00024219262,
-0.014562914,
0.0019424921,
-0.038552772,
0.0097900275,
-0.021903785,
-0.001388791,
-0.014272448,
-0.01485338,
-0.026564445,
0.027039753,
0.014602523,
0.0016528511,
0.0043734955,
0.018140929,
0.0153947035,
-0.028148806,
-0.004654059,
0.0018385184,
-0.036149826,
-0.035700925,
-0.017375154,
0.019170763,
-0.00971081,
-0.030472534,
0.011037712,
0.0060073673,
-0.017295936,
-0.014760959,
-0.0032891985,
-0.032268144,
0.038499963,
0.019540446,
0.0038090667,
-0.03176643,
-0.006070081,
-0.0111565385,
0.010126704,
-0.0042777737,
-0.00435039,
0.0074729007,
-0.0033667663,
0.0013004959,
-0.0015265974,
-0.01972529,
-0.024993287,
0.0022494618,
0.008852614,
0.00562448,
-0.006086585,
0.016820628,
-0.015038222,
-0.02799037,
0.007466299,
-0.024069076,
-0.04280414,
-0.017322343,
-0.008337697,
0.034327812,
0.009532569,
0.025508204,
-0.00043281098,
0.016134072,
0.022101829,
0.028465677,
0.01885389,
-0.0065684947,
0.01169126,
-0.011684659,
0.013354839,
0.014576117,
-0.021151213,
0.007796374,
0.012377817,
0.0030928038,
0.003594518,
-0.017876869,
-0.013222809,
0.028993798,
-0.031396747,
-0.021824567,
0.00931472,
-0.009077066,
0.011783682,
-0.04169509,
0.003445984,
-0.004479119,
0.010496388,
0.012879531,
0.02395025,
0.023686191,
-0.0117044635,
0.026339995,
-0.01806171,
0.03102706,
-0.0053274124,
-0.012146764,
-0.0022379092,
-0.01287293,
0.019976147,
-0.008707382,
0.009902254,
0.006099788,
-0.023659784,
0.010265336,
0.018391786,
-0.019936537,
-0.009532569,
0.00091430807,
0.012754102,
-0.01634532,
-0.0109848995,
-0.016860237,
-0.022049017,
-0.022827994,
0.001239432,
-0.020636296,
0.015724778,
-0.0041853525,
0.0019854018,
0.022128236,
-0.0034426835,
0.04710832,
-0.00047489558,
0.027673498,
0.015790794,
0.015592748,
-0.031132685,
-0.008819607,
-0.015526733,
0.000050155944,
0.034855932,
0.047134727,
0.0015257723,
-0.005980961,
0.009413742,
0.0022775184,
-0.03308673,
-0.036704354,
0.014153621,
-0.0041853525,
0.0030152362,
0.0050996607,
0.006033773,
-0.019144356,
0.020662703,
-0.010839667,
0.007466299,
-0.012707892,
-0.01225899,
-0.0018022101,
0.0021306348,
-0.0064166603,
0.017295936,
-0.014034794,
-0.022273468,
0.008113246,
-0.040665254,
0.015803996,
-0.025362972,
0.0052845026,
0.026036326,
0.011004704,
-0.009189291,
0.032373767,
0.017599605,
0.013275621,
-0.023831423,
-0.006499179,
0.036493104,
-0.006070081,
-0.013156794,
-0.0000728744,
0.009644795,
0.014074403,
0.0051425705,
0.00057804404,
-0.022656355,
-0.019738492,
0.0080802385,
0.033773284,
0.015064628,
-0.0025102212,
0.0074927052,
-0.021032386,
0.008067036,
-0.035093587,
-0.018022101,
0.0153947035,
-0.04784769,
-0.020689107,
0.0048851115,
0.0039906083,
0.031370338,
0.013401049,
0.0053736228,
-0.012622072,
0.03971464,
-0.03665154,
0.0016536763,
-0.018510612,
-0.0026521536,
-0.036070608,
0.0020415145,
-0.031634398,
-0.03329798,
0.010866073,
-0.029099422,
-0.011585636,
-0.028861769,
0.00046788147,
0.026590852,
0.01819374,
-0.016266102,
0.028095994,
-0.026736084,
0.017850462,
-0.010133306,
-0.0061426978,
0.03049894,
-0.0064166603,
0.010040885,
-0.0026224467,
0.0072484496,
-0.010496388,
-0.0020629694,
-0.020121379,
0.0019771499,
-0.02398986,
-0.021969799,
-0.02338252,
0.008595156,
-0.028228024,
0.005502352,
0.011882704,
-0.000042290874,
-0.007631337,
-0.015104237,
0.007439893,
0.014602523,
0.001283167,
0.00079300546,
-0.0003655582,
-0.007175833,
-0.022775183,
-0.0064562694,
0.0032116307,
-0.024108686,
-0.010351156,
0.022946822,
-0.024333138,
0.02600992,
0.004908217,
-0.010753848,
-0.0029162136,
0.009248705,
-0.03710044,
-0.026749287,
-0.0073408703,
0.01577759,
-0.016675394,
0.014523305,
0.01485338,
0.006367149,
-0.009420344,
-0.009110074,
-0.0056046755,
-0.011592238,
0.0075521185,
-0.028254429,
0.015302282,
0.005370322,
-0.032162517,
-0.009605186,
0.03665154,
-0.0061724046,
-0.028016776,
0.026960535,
-0.021336054,
0.014034794,
-0.020359034,
0.0020728717,
-0.008166058,
0.00602057,
0.015790794,
-0.02004216,
-0.016173681,
0.0062681264,
-0.011849697,
-0.028967392,
0.005198683,
0.020121379,
0.028412865,
-0.0074861036,
-0.0103379525,
-0.025653439,
0.006601502,
-0.035700925,
0.016173681,
0.004627653,
0.015302282,
-0.014180027,
0.023408927,
-0.004934623,
-0.021428477,
0.010205923,
-0.023224086,
-0.004561638,
0.017493982,
0.0070305998,
-0.014602523,
-0.004426307,
-0.004007112,
-0.030050037,
0.0124900425,
-0.012417425,
-0.014351666,
-0.018801078,
0.014483696,
0.021164415,
-0.010938689,
-0.008278284,
-0.0003115084,
-0.00883281,
0.005862134,
0.0119421175,
-0.0021702438,
-0.017177109,
0.022088626,
-0.0056343824,
-0.017744837,
0.004059924,
0.016490553,
0.000837153,
-0.010344554,
0.005304307,
0.18917266,
-0.02276198,
0.020028958,
0.0018022101,
-0.01783726,
0.006551991,
0.009248705,
0.0027891346,
0.009400539,
-0.0015728079,
0.0132426135,
-0.0050600516,
-0.022299875,
0.0064034574,
0.01138099,
-0.0021916986,
-0.032452986,
-0.016847033,
-0.04644817,
0.008905427,
-0.0010966746,
-0.012384418,
0.013255817,
-0.010205923,
0.032901887,
0.0025118715,
-0.033799693,
0.0072220434,
0.00848293,
0.015698373,
-0.0020464656,
-0.027541468,
-0.0051260665,
-0.0014473794,
0.018312568,
0.03168721,
-0.012674884,
0.015130643,
-0.0005483373,
-0.010740644,
0.0070239985,
0.028228024,
0.0044758185,
-0.03765497,
0.002975627,
-0.018563425,
0.001665229,
-0.004188653,
0.007875592,
0.000064570944,
-0.067176886,
0.02017419,
0.008984645,
0.017916476,
-0.013282223,
-0.003739751,
-0.0041028336,
0.02127004,
-0.00027251826,
0.032136112,
0.0045880442,
0.00602057,
-0.031872053,
0.017282734,
-0.020887153,
0.032241736,
-0.0012872929,
-0.004891713,
0.024451964,
-0.03321876,
0.002368289,
0.00094236445,
-0.042936172,
0.0052184877,
-0.0033106534,
-0.0041490444,
0.014351666,
0.010522795,
0.012212779,
0.028095994,
0.0046738638,
-0.012001531,
-0.04459975,
0.0016058154,
0.0016982364,
-0.030842219,
0.02478204,
0.00140612,
-0.009512764,
-0.0065321866,
0.005003939,
0.007004194,
-0.00047076962,
-0.002640601,
0.010080494,
0.022128236,
-0.022313077,
-0.014787365,
0.020160988,
-0.015988838,
-0.040797286,
0.08254518,
0.005370322,
0.016186884,
0.008278284,
-0.0020365634,
-0.0062549235,
-0.014404478,
0.0012072497,
-0.033245165,
0.021903785,
-0.019117951,
0.0099946745,
0.0074861036,
0.010892479,
-0.0015571293,
0.027435843,
-0.013519877,
0.02702655,
0.0015983888,
0.009862645,
0.0037331495,
0.005056751,
0.036968414,
-0.0056574875,
0.003396473,
-0.0077171563,
0.011130133,
0.0031835744,
-0.038816832,
-0.0014622328,
0.0039080894,
0.008766795,
-0.006773141,
0.014760959,
-0.024980085,
0.030340504,
-0.019738492,
-0.017335545,
0.02189058,
-0.01700547,
-0.018867094,
-0.013024764,
0.0084235165,
0.000861496,
-0.022035815,
0.0126946885,
0.022695964,
0.010615216,
-0.0032924993,
0.016992267,
-0.017388357,
-0.004630954,
-0.009268509,
0.022999633,
-0.037153255,
-0.010621817,
-0.03620264,
-0.008007622,
0.002658755,
-0.029838791,
0.0019061838,
-0.0053901267,
-0.014047997,
-0.01687344,
0.013209606,
-0.16540724,
0.010846268,
0.0018418191,
-0.012140162,
0.029337076,
0.00795481,
0.006618006,
0.004522029,
0.0016206688,
0.00065148575,
0.027963964,
0.001634697,
-0.031581588,
-0.03871121,
-0.0045418334,
-0.0073804795,
-0.014034794,
0.034591872,
0.035806548,
0.0072352467,
0.01810132,
-0.0059611565,
0.014998613,
-0.008119848,
0.016794221,
0.008773397,
0.0035615105,
-0.018246552,
0.013420854,
-0.006182307,
0.008945036,
0.029416295,
0.030393317,
0.0036902397,
0.017177109,
0.014140418,
0.013836749,
-0.010826464,
-0.009532569,
0.018972717,
0.005848931,
0.01392917,
-0.002407898,
0.007994419,
-0.00032677437,
0.021085199,
-0.016715003,
-0.007109818,
0.019936537,
0.0018154131,
0.0014391275,
-0.0075389156,
0.022695964,
0.017388357,
0.038024653,
-0.0011602141,
0.0074729007,
0.011862899,
-0.008185863,
-0.009215697,
-0.014708147,
-0.02474243,
0.025917498,
-0.017626012,
0.017612807,
-0.009044058,
0.0031093075,
-0.0010562404,
-0.03018207,
0.017216718,
-0.023316506,
-0.026128747,
0.0042909766,
-0.026300386,
0.020147786,
0.025732655,
-0.0029360182,
0.014615726,
-0.0052977055,
0.007096615,
-0.009011051,
0.0028898076,
-0.018761469,
-0.017480778,
0.01217317,
-0.0013203005,
-0.001638823,
0.0059776604,
-0.018035304,
-0.023725798,
0.02276198,
-0.026709678,
-0.005558465,
-0.005505653,
0.008245276,
0.015407906,
-0.0065717953,
-0.012476839,
-0.0147477565,
-0.0052448935,
0.035093587,
-0.02166613,
-0.013163395,
0.03884324,
0.0059314496,
0.01265508,
-0.01564556,
0.000689857,
0.035885766,
0.00501054,
-0.0047662845,
0.0028188415,
0.004413104,
0.018919906,
0.009440148,
-0.00060362485,
-0.00086562196,
-0.013836749,
-0.005898442,
-0.017586403,
0.057723537,
0.013513275,
-0.024135092,
0.007585126,
-0.010212524,
-0.011783682,
-0.1428037,
0.0045517357,
0.019051936,
0.011836493,
-0.0055353595,
0.03329798,
0.0014638831,
0.0045154276,
-0.011975125,
0.019804507,
-0.030340504,
-0.0050369464,
-0.012998358,
-0.02421431,
-0.0093807345,
0.01651696,
0.0053208107,
-0.0051425705,
-0.008562149,
0.037496533,
0.01753359,
-0.02170574,
0.0036968412,
-0.013486869,
0.028439272,
-0.0036836383,
-0.010978298,
0.016054854,
0.008152856,
0.010258734,
-0.011050914,
-0.017111095,
0.0019754996,
0.009110074,
-0.014892989,
-0.008331096,
0.007189036,
0.0014052948,
0.009011051,
-0.010139908,
0.0033205557,
-0.010258734,
0.006010668,
-0.010668027,
0.027541468,
-0.021190822,
-0.0124900425,
0.010549201,
0.026445618,
-0.0034987961,
-0.023778612,
-0.01243723,
-0.031185497,
-0.022577139,
0.02904661,
-0.013143591,
0.02865052,
0.042645704,
-0.025191333,
0.00979663,
-0.008575352,
0.01573798,
-0.01309738,
0.028676925,
0.04190634,
-0.025534611,
0.007585126,
-0.00038412493,
0.04288336,
-0.048375808,
-0.0034591872,
-0.01972529,
-0.005822525,
-0.013585892,
-0.0082188705,
-0.009539171,
-0.012721095,
-0.02970676,
-0.0000031927675,
-0.023963453,
0.0122523885,
-0.018603034,
0.012192975,
-0.016715003,
0.008383908,
0.008826208,
0.013513275,
-0.0077171563,
0.00062920566,
-0.017573198,
0.0122523885,
0.038235903,
0.0030663977,
0.0066213068,
-0.013394448,
-0.010126704,
0.0027132174,
-0.001704838,
-0.0022445107,
0.033641256,
-0.025693046,
-0.01647735,
-0.05782916,
0.012067546,
-0.026432415,
-0.0045880442,
0.03374688,
0.0016949357,
0.005383525,
0.00017865315,
-0.006264826,
0.0021983003,
-0.021943394,
0.008654569,
-0.019514041,
0.0036308262,
-0.041985553,
0.014959004,
0.0347239,
0.00795481,
0.025891092,
0.029521918,
0.0006213664,
-0.016041651,
0.003445984,
-0.0015067928,
-0.01472135,
-0.004323984,
-0.013770734,
0.012027937,
-0.017744837,
0.02100598,
-0.0036671346,
-0.017863665,
-0.017045079,
0.005782916,
-0.007677547,
-0.03393172,
-0.00048521042,
0.022260265,
0.0065916,
0.019514041,
-0.0035846157,
-0.03897527,
0.012225982,
0.008403712,
0.032585014,
-0.011341381,
-0.029865196,
-0.010225727,
0.009334524,
-0.026472025,
0.026683273,
0.0134472605,
0.0008705731,
-0.02140207,
0.0006943955,
0.0059743593,
-0.000487686,
-0.032585014,
-0.009512764,
-0.031713616,
-0.005505653,
0.027805528,
0.0075455173,
0.013018163,
0.02004216,
-0.0008181737,
-0.02253753,
-0.015315485,
0.028148806,
-0.0027016648,
0.00020877252,
0.017890071,
0.00041506946,
0.004099533,
0.022035815,
-0.00316377,
0.0018583229,
0.018404989,
-0.022946822,
-0.0033370594,
0.010694434,
-0.016411334,
-0.021243634,
0.0069051716,
0.02865052,
-0.0038156684,
0.003726548,
0.007677547,
0.0072220434,
-0.0049775327,
0.009651396,
0.029997226,
-0.0038618788,
0.0048719086,
0.010232328,
0.019448025,
-0.0020365634,
0.0060832845,
0.028544895,
0.03744372,
0.0068787653,
-0.0012971952,
0.0048752096,
-0.0037331495,
-0.009024254,
0.018180538,
-0.01656977,
-0.04731957,
-0.007835983,
-0.015077831,
0.008403712,
0.008727186,
0.0027676797,
0.0011305072,
0.0008730487,
0.024174701,
0.01085287,
-0.0002964487,
-0.0097570205,
0.044045225,
-0.00014770862,
0.017612807,
0.0027561272,
-0.012760703,
0.02451798,
0.017771244,
0.025415784,
-0.031581588,
0.012628674,
-0.01243723,
0.0069975923,
-0.032875482,
-0.017678823,
-0.027779121,
-0.007070209,
-0.009143081,
-0.013968779,
0.014694944,
-0.004947826,
0.070187174,
0.026722882,
-0.0023963454,
-0.015038222,
-0.013717921,
0.025046099,
0.012734298,
0.011341381,
-0.020385439,
-0.011473411,
0.022458311,
-0.0058786375,
-0.012457035,
-0.033509225,
-0.028940987,
0.012245786,
-0.029944414,
0.013968779,
-0.0017559996,
-0.0036539314,
0.013942373,
-0.007743562,
0.019989349,
-0.0012146764,
-0.026511634,
0.0013516576,
0.028043183,
-0.0036011194,
-0.013414253,
-0.020728717,
0.0070107956,
0.008786599,
-0.031845648,
-0.016807424,
0.010753848,
-0.010489787,
-0.011394192,
-0.010450178,
0.045022245,
0.005234991,
-0.008515938,
-0.00856875,
-0.022709168,
-0.002452458,
0.010384163,
0.0009877498,
-0.032241736,
0.003634127,
-0.0020976274
] |
Rett syndrome (RTT) is an inherited neurodevelopmental disorder of females that occurs once in 10,000–15,000 births. Affected females develop normally for 6–18 months, but then lose voluntary movements, including speech and hand skills. Most RTT patients are heterozygous for mutations in the X-linked gene MECP2 (refs. 3–12), encoding a protein that binds to methylated sites in genomic DNA and facilitates gene silencing. Previous work with Mecp2-null embryonic stem cells indicated that MeCP2 is essential for mouse embryogenesis. Here we generate mice lacking | [
-0.058597066,
-0.009975515,
0.00027868146,
-0.030647112,
-0.0022790318,
0.013254412,
-0.0038441103,
0.0021649976,
-0.006683397,
0.003735034,
0.0067296717,
0.027315328,
0.012943711,
-0.0029962906,
0.017663736,
0.009406997,
0.023071272,
0.02206645,
0.032709643,
-0.012375193,
-0.0006672655,
-0.0009478062,
0.012956932,
-0.019408956,
-0.00082509546,
-0.02295228,
0.022687852,
-0.021445045,
0.004101927,
-0.013644443,
0.004382881,
-0.0014262542,
-0.0025004896,
-0.035909213,
-0.015574762,
0.001712166,
-0.006366085,
-0.004792743,
0.017134883,
-0.017610852,
0.006138016,
0.028187938,
-0.00009678448,
0.018800773,
-0.0163416,
0.009684646,
-0.008633547,
-0.01371055,
0.006124795,
-0.002809539,
-0.0038771636,
0.022423426,
-0.039320324,
0.0018592536,
-0.018985871,
-0.0021616924,
0.0027384742,
0.015442547,
0.0046737506,
-0.019435398,
0.012718948,
0.01069608,
-0.048786815,
-0.00047803478,
0.0022013565,
-0.012785055,
-0.014411282,
0.0019617192,
0.00088004675,
0.04024582,
0.024552064,
0.024485957,
0.024353744,
0.0001048929,
0.020691428,
-0.0037019807,
-0.024274416,
0.0073841293,
0.0020493106,
-0.004009377,
0.02627084,
-0.009360722,
0.0016022635,
0.020506328,
0.036173638,
-0.00758245,
-0.028531693,
0.023322478,
-0.0020261733,
-0.006263619,
0.02255564,
0.00481588,
-0.0035962097,
0.004845628,
-0.0067065344,
0.011833116,
0.005037338,
0.02625762,
-0.010458095,
-0.031942803,
-0.0051893834,
0.028769678,
-0.036173638,
0.0005412494,
-0.0096449815,
0.0032061797,
0.006769336,
-0.0002185656,
0.0021550816,
-0.023679454,
-0.03358225,
0.025147026,
0.007033763,
-0.0072320835,
0.019184193,
0.004399407,
0.02821438,
0.030488456,
0.007985701,
-0.0037614768,
0.040510245,
0.0051364983,
-0.00029066333,
-0.020003917,
0.012487574,
0.000020271029,
-0.04794065,
-0.000670984,
-0.003480523,
-0.004941483,
-0.013108978,
-0.023097714,
0.022463089,
0.010160615,
-0.013829542,
0.008812036,
-0.009387165,
-0.012414857,
-0.02091619,
-0.026019635,
0.00047679528,
-0.0018873491,
-0.027579756,
0.0046638343,
-0.008818647,
0.0008668254,
-0.0023864554,
-0.0016187902,
0.018219033,
-0.0039961557,
0.011033225,
-0.016024288,
0.006104963,
-0.008402174,
0.012791665,
0.025437895,
0.0039333543,
0.023772005,
-0.01828514,
-0.035459686,
-0.008646769,
0.013432901,
-0.0037746981,
0.022740738,
0.020876527,
0.021273168,
0.023163822,
-0.020559214,
0.025001591,
0.0036226525,
-0.028531693,
0.015521876,
-0.03239233,
0.0067660306,
0.0030971034,
0.014318733,
-0.017729843,
0.018430576,
-0.008937639,
-0.0155086545,
-0.026905466,
0.038844354,
0.020942634,
0.006809,
-0.020982297,
0.010629973,
0.00943344,
0.0022641579,
-0.00015782999,
-0.0048224907,
0.0051398035,
-0.0073973504,
0.01381632,
-0.0090566315,
-0.6287021,
-0.008223685,
0.0139088705,
0.015799524,
0.008732708,
0.03191636,
-0.0067825573,
-0.009301227,
-0.020572435,
0.028161496,
0.0027120314,
0.011429865,
-0.008157579,
-0.016513478,
-0.010643194,
-0.015231006,
-0.0112579875,
-0.0015683838,
0.010986949,
0.009711089,
-0.03995495,
0.029007662,
-0.017346423,
0.017108439,
-0.010378767,
0.007767549,
-0.0015411148,
0.0040490413,
-0.005037338,
0.036834706,
-0.0120777115,
0.009909409,
-0.0130891455,
0.002948363,
0.05621722,
-0.0069412137,
-0.0028475502,
0.034190435,
-0.004604338,
0.037125576,
-0.02966873,
0.004792743,
0.01632838,
-0.009446661,
-0.016024288,
-0.0074899,
-0.019713046,
0.0013626263,
0.020149352,
-0.017253874,
-0.020625321,
-0.01176701,
-0.0026723673,
-0.027064122,
0.013360184,
-0.01946184,
0.011786842,
-0.0054306732,
0.028373037,
0.0015890421,
-0.009968905,
0.032921184,
0.0134857865,
0.011720736,
0.0025137109,
-0.0004115148,
-0.001958414,
-0.007714663,
0.00037618898,
-0.036226526,
-0.007734495,
0.05288544,
-0.0017534829,
0.031043751,
0.014450946,
0.029351419,
-0.0106564155,
0.014794701,
-0.016354822,
0.008858311,
-0.01312881,
-0.013413069,
-0.031255294,
0.0028359815,
0.037654433,
-0.023415027,
-0.0151649,
0.030990867,
-0.010709302,
0.0260593,
0.0037581713,
0.006068604,
0.0061413213,
-0.036226526,
-0.011747178,
0.014358397,
0.0049150405,
0.029245647,
0.0042043924,
-0.004657224,
-0.011542247,
-0.016645692,
0.028822564,
0.021987122,
0.015323556,
0.0108745685,
-0.028716793,
0.006795779,
0.025874201,
0.015389662,
-0.017941386,
-0.014966579,
0.0066536493,
-0.019170972,
-0.022198662,
-0.019620497,
-0.0040192935,
0.0058306195,
-0.010061455,
-0.025279239,
-0.00432669,
0.0009618539,
0.023613349,
0.0015989582,
-0.004872071,
0.007556007,
-0.0012832982,
0.007430404,
0.0056058564,
-0.009585486,
0.0044291555,
-0.008679822,
0.026958352,
-0.02304483,
0.022436647,
-0.004402713,
0.02285973,
-0.021259947,
-0.00062223023,
-0.02044022,
-0.002844245,
0.009030188,
0.0021815244,
-0.0017716622,
-0.010808461,
-0.007846877,
0.0014576549,
-0.021312831,
0.0006242961,
0.0016956393,
0.0032078323,
0.00154442,
0.007575839,
0.027579756,
-0.0014055958,
-0.022053227,
-0.04037803,
-0.019660162,
-0.007655167,
-0.038553484,
0.014834365,
0.011132385,
0.007304801,
-0.017941386,
-0.017676957,
-0.023309257,
-0.018298361,
0.025887422,
-0.021484708,
-0.028531693,
-0.009506158,
-0.0030309965,
-0.0038143622,
-0.013313909,
0.0082633495,
0.026389834,
0.0012568554,
-0.0017832308,
-0.016169723,
-0.013082535,
0.0019435398,
-0.006934603,
-0.019594055,
-0.01303626,
0.013723771,
0.0072981906,
0.018073598,
-0.010246553,
0.00962515,
0.01993781,
-0.018615674,
0.034507748,
-0.019501505,
0.009301227,
0.020678205,
-0.0133072985,
0.03228656,
0.005503391,
-0.009083074,
0.049659427,
0.012533849,
-0.008825257,
0.008871532,
0.0075493963,
0.011515804,
-0.029695174,
0.003840805,
-0.014636045,
0.007952647,
-0.0053612613,
-0.02400999,
0.009836691,
0.0019418872,
-0.0025765125,
-0.025530444,
0.020770757,
-0.004211003,
0.013439512,
-0.031334624,
-0.0149798,
-0.0015576414,
-0.012018216,
-0.0001601024,
0.017055554,
0.02091619,
0.009664814,
-0.0066205957,
-0.007370908,
0.017584408,
-0.017663736,
-0.012190093,
0.008732708,
0.006534657,
0.0028277182,
-0.016738242,
0.021802021,
0.0036887592,
-0.0041250642,
0.0130759245,
0.023309257,
-0.0014022904,
-0.011198492,
-0.0020658374,
-0.02129961,
0.012923879,
-0.015865631,
0.03228656,
0.013267634,
-0.00924173,
0.014794701,
-0.01138359,
0.009572264,
-0.033529367,
0.016976226,
-0.004587812,
0.008355899,
0.02032123,
-0.0027302108,
0.052858993,
0.030118257,
0.029060548,
-0.019316407,
-0.002274074,
-0.020175794,
-0.009638371,
0.0060355505,
0.014146854,
0.01186617,
0.014014641,
-0.0062074284,
-0.018655337,
-0.013168474,
-0.01234875,
-0.005186078,
0.019237079,
0.010332492,
-0.009175624,
0.011786842,
0.018060377,
0.014146854,
-0.0133072985,
-0.04405357,
0.025279239,
0.030356241,
-0.029298533,
-0.008805426,
-0.0049547045,
-0.0013056092,
-0.006789168,
0.011410033,
0.011714124,
0.022846509,
-0.00082757446,
0.014371618,
-0.000337971,
-0.007919595,
0.03167838,
-0.020017138,
0.013736992,
-0.028082168,
0.0050075897,
0.0041283695,
-0.013842763,
0.0046440023,
-0.006428886,
0.021312831,
-0.030356241,
-0.0090434095,
-0.020347672,
-0.014596381,
0.01283794,
-0.026588153,
0.009400386,
-0.010782018,
-0.015204564,
0.006613985,
0.0074171824,
-0.0017501775,
0.011072889,
-0.010246553,
-0.01817937,
-0.03239233,
-0.0082633495,
0.004415934,
0.0303298,
0.04656563,
-0.016222607,
0.010570477,
-0.015125236,
0.005077002,
-0.0036524006,
-0.02927209,
0.01595818,
-0.019818818,
0.0024211614,
0.0014997979,
0.014133633,
0.007132923,
-0.002974806,
0.01011434,
0.032207232,
-0.016037509,
-0.0045349263,
0.011317484,
0.0077212737,
-0.0019352764,
0.010299439,
0.024261195,
0.016103616,
-0.027923511,
0.012771833,
0.017187767,
0.009083074,
-0.015402883,
-0.00016289129,
-0.013016429,
-0.017002668,
0.006868496,
0.009459883,
-0.012672673,
0.007450236,
-0.011158828,
0.02188135,
0.021484708,
0.021921014,
0.02694513,
0.0032607177,
0.0037317288,
0.021656586,
-0.004885292,
-0.003034302,
0.000735025,
0.0016989447,
-0.031096637,
0.02810861,
0.009030188,
-0.010173836,
0.004214308,
0.009050021,
0.004796048,
0.0052191317,
-0.019170972,
-0.009982127,
-0.0139088705,
0.0072585265,
-0.029774502,
-0.017769506,
-0.012322307,
-0.006061993,
0.0013973324,
0.017967828,
0.0004358917,
-0.03424332,
-0.024261195,
0.0063859164,
-0.007886541,
-0.02383811,
-0.009321058,
0.0082369065,
0.029933158,
0.0034772176,
-0.005612467,
0.021180619,
0.040140048,
-0.003969713,
-0.008422006,
-0.0049183457,
0.009307837,
0.013578336,
0.016315158,
0.022344097,
-0.0073510758,
-0.0021286388,
0.030144699,
0.025001591,
-0.033820238,
0.024538843,
0.0030574393,
-0.030197585,
0.024459515,
0.017650515,
0.03781309,
-0.019713046,
-0.011072889,
-0.006478466,
-0.029695174,
-0.02081042,
-0.02810861,
-0.011337316,
-0.012599955,
0.006144627,
0.011852949,
-0.016473813,
-0.026588153,
-0.003989545,
-0.010358935,
-0.0006251224,
0.0041581173,
0.006362779,
0.024433073,
0.022106113,
0.030964423,
0.02032123,
0.008111304,
0.012071101,
-0.016315158,
0.011264598,
-0.009149181,
-0.022529196,
0.03392601,
0.023428248,
-0.02238376,
-0.030620668,
0.0033383933,
0.0082369065,
0.0412242,
-0.0077939914,
-0.038817912,
-0.037416447,
-0.009955684,
-0.0231506,
-0.006164459,
-0.009162402,
0.0008333588,
0.0017881888,
0.016077174,
-0.027262444,
-0.012342139,
0.01926352,
-0.03569767,
0.0004813401,
0.0022558945,
-0.0092615625,
0.016526699,
-0.007139534,
0.032022133,
-0.025014812,
-0.01605073,
0.005804177,
-0.045640133,
0.019382512,
-0.02508092,
0.023058051,
0.012996596,
0.013803099,
-0.004862155,
0.0246975,
-0.0077014416,
0.027236,
0.00080980826,
0.019541169,
-0.018999094,
-0.010180446,
0.015746638,
-0.008501334,
0.023983546,
0.029536517,
-0.0090434095,
0.008666601,
0.03649095,
0.0031764316,
-0.025451116,
-0.0065809316,
-0.03723135,
0.0016014371,
0.017835613,
0.0036920647,
0.017809171,
-0.022198662,
-0.0016543226,
0.031017309,
0.013472565,
-0.0016014371,
0.0067296717,
0.015997846,
-0.008706265,
0.0074766786,
-0.04608966,
0.016513478,
0.0072519155,
0.0029830693,
0.0052753226,
-0.022476312,
0.009155791,
0.0005784345,
0.012970153,
0.002508753,
0.003049176,
-0.005133193,
-0.007906373,
-0.035248145,
-0.011548857,
-0.035539012,
-0.009380555,
-0.011343926,
-0.013974977,
0.0095326,
-0.021365717,
0.02578165,
0.0069676563,
-0.033106282,
0.04384203,
-0.012652841,
-0.028161496,
0.00028673824,
-0.033820238,
-0.003313603,
-0.026336947,
0.02120706,
0.011965331,
-0.010742354,
-0.007615503,
-0.011238156,
0.02694513,
0.0046539186,
0.062087502,
0.027553312,
-0.015720196,
-0.0007738627,
0.020043582,
0.014874029,
-0.036305852,
-0.050822906,
-0.0070668166,
0.0012816455,
-0.012606566,
-0.0072717476,
0.0024938788,
-0.019765932,
0.010815072,
-0.03405822,
-0.027315328,
-0.0077080526,
-0.007899762,
-0.014212961,
0.018536346,
-0.015905295,
0.013346963,
0.0015807787,
0.019184193,
-0.010663026,
-0.006428886,
-0.01632838,
0.018311583,
-0.0027946648,
0.024049653,
-0.02139216,
0.022886174,
0.0012196704,
-0.012970153,
-0.010358935,
-0.0117604,
-0.03355581,
0.03939965,
-0.015918517,
-0.021273168,
-0.003313603,
0.0050307275,
-0.0055893296,
0.0084550595,
0.0015278934,
-0.035168815,
-0.015059128,
-0.015706975,
0.023692677,
0.00151963,
-0.005116666,
0.0023963714,
-0.015402883,
-0.00495801,
-0.029774502,
-0.049765196,
0.017174546,
-0.03725779,
-0.006399138,
0.00054331525,
0.011092721,
-0.002237715,
0.020889748,
-0.017002668,
-0.008375731,
0.03675538,
-0.026284063,
0.0023798447,
-0.014027863,
-0.0012320654,
0.015640868,
0.005182773,
-0.0008569094,
-0.026627818,
0.019633718,
-0.022119334,
-0.0080584185,
-0.021907793,
0.004230835,
-0.0018146316,
-0.0024376882,
-0.028267266,
0.038341943,
0.006104963,
-0.0002425293,
-0.008924417,
-0.008184021,
0.0025318903,
0.024300858,
-0.0020245207,
-0.00036916515,
0.0007102349,
0.008818647,
0.007265137,
0.0150987925,
0.0017286928,
-0.011859559,
0.014926915,
0.0042341403,
0.0040292093,
-0.021643365,
-0.0029962906,
-0.013803099,
-0.0002476939,
-0.017108439,
0.01614328,
0.0023963714,
-0.025927085,
-0.003946576,
0.027500428,
-0.014173297,
0.029034106,
0.00233357,
-0.0021583869,
0.00034334217,
-0.00797909,
-0.031149523,
-0.011852949,
-0.021537594,
0.035274588,
0.015297113,
-0.0077080526,
-0.019990696,
0.0147021515,
-0.03842127,
-0.01224959,
0.0045944224,
-0.00064330176,
0.01877433,
0.02616507,
0.008567441,
-0.002854161,
-0.015085571,
0.021656586,
-0.033238497,
-0.0059595276,
0.008422006,
-0.005242269,
-0.0022327572,
0.013439512,
-0.028135052,
0.010431653,
0.041805938,
0.0008255086,
-0.015746638,
0.005952917,
0.016077174,
-0.006554489,
-0.024433073,
0.016513478,
0.013532061,
0.0068817176,
0.019660162,
0.0049084295,
-0.00039106302,
0.014768259,
0.008884753,
-0.020453444,
-0.00078791037,
0.016513478,
0.008792204,
-0.0128842145,
-0.028849006,
-0.0038540263,
0.0054009254,
-0.017663736,
0.027844183,
0.0056455205,
0.0043167737,
-0.00058917684,
0.009982127,
0.0040192935,
-0.0017683568,
-0.009506158,
-0.00052802806,
0.0061710696,
0.007939426,
-0.014940136,
-0.035777,
0.014926915,
-0.0054306732,
-0.0151649,
-0.021564037,
-0.005483559,
-0.014543495,
-0.036411624,
0.018840438,
0.023613349,
-0.011608354,
-0.0020460053,
-0.0071791983,
-0.021431824,
-0.0043333005,
-0.013961756,
0.01605073,
-0.038817912,
-0.010986949,
-0.01302965,
-0.017663736,
-0.0039432705,
0.013974977,
-0.02703768,
-0.028769678,
0.023005165,
0.19197413,
-0.011218323,
0.0013064356,
0.0072122514,
-0.014821144,
-0.01778273,
0.0066007636,
-0.004181255,
-0.0074171824,
0.006154543,
-0.00201791,
-0.017848834,
-0.012791665,
0.0139088705,
0.0008626937,
-0.022899395,
-0.014569938,
-0.02966873,
-0.0044291555,
-0.0151649,
0.016487036,
0.0063958326,
-0.007906373,
-0.032313004,
0.03384668,
0.016711798,
-0.0274211,
-0.012765222,
0.0064255805,
0.015587983,
-0.019792374,
0.0047993534,
0.010557256,
-0.008547609,
-0.016301936,
0.002318696,
0.0064057484,
-0.00973092,
-0.014054305,
0.014318733,
0.009089685,
0.039716963,
0.021378938,
0.0015692101,
-0.014940136,
0.02275396,
-0.0041448963,
-0.020479886,
-0.0082633495,
-0.02449918,
-0.03247166,
0.021074846,
0.009221898,
0.011932277,
-0.0033565727,
0.00062553555,
0.009050021,
0.021326052,
-0.012798276,
0.011588521,
-0.014953357,
0.01799427,
-0.036438067,
0.04095977,
-0.022740738,
0.048575275,
-0.01059692,
-0.008964081,
-0.008937639,
-0.019673383,
-0.026217956,
-0.034216877,
-0.018113263,
0.009122738,
-0.020889748,
-0.03289474,
0.027209558,
0.029695174,
0.009116127,
0.024578508,
-0.0036160417,
-0.005394315,
-0.020783978,
-0.005747986,
-0.025054475,
-0.04727958,
0.031308178,
0.008540998,
-0.005658742,
-0.011178659,
0.02189457,
-0.027288886,
-0.0065974584,
0.0041382853,
0.016751463,
0.012963543,
0.0023087799,
-0.0006362779,
-0.014622823,
-0.008190632,
-0.036305852,
0.052964766,
0.0056554363,
-0.0040126825,
0.002107154,
0.010920843,
-0.024287637,
0.012699116,
0.0138824275,
-0.02022868,
-0.023322478,
-0.009975515,
0.008706265,
-0.0017336508,
-0.0046142545,
0.008607105,
-0.00016599003,
-0.010180446,
0.00039808688,
-0.00095524325,
0.016949782,
-0.03432265,
-0.004247362,
0.017108439,
-0.01371055,
-0.008937639,
-0.018417353,
-0.003969713,
-0.0016113531,
-0.022568861,
-0.0072585265,
-0.018840438,
-0.012725558,
-0.015587983,
-0.004832407,
-0.03326494,
0.025014812,
-0.0047894376,
-0.022040006,
0.030382684,
0.0015361567,
0.01371055,
0.008587273,
0.017967828,
0.017425751,
-0.03188992,
-0.0067528095,
0.027288886,
-0.01284455,
0.0026657565,
-0.03715202,
-0.019977475,
0.0066007636,
-0.011152216,
0.0000234989,
-0.0054306732,
-0.008904586,
-0.014675709,
-0.0012568554,
0.026046079,
-0.0274211,
0.01790172,
0.0024013293,
0.012923879,
-0.009684646,
-0.007185809,
-0.16606027,
-0.013380016,
0.007926205,
-0.039716963,
0.022000343,
0.008435227,
0.024935484,
-0.004607644,
0.005212521,
0.021220282,
0.013855984,
-0.0065412675,
-0.0046704453,
-0.012970153,
0.00031421386,
0.0106564155,
-0.035935655,
0.03141395,
0.030382684,
-0.008997135,
0.0406689,
-0.046618514,
0.015085571,
-0.016883677,
0.014424503,
0.0030855348,
0.011429865,
-0.03260387,
0.01614328,
-0.020678205,
0.0037019807,
-0.022106113,
0.038817912,
-0.0048985137,
0.028346594,
-0.009347501,
0.011753788,
0.013763435,
0.0036028204,
0.0126792835,
0.0206121,
0.043974243,
0.011072889,
-0.0074237934,
-0.0149798,
0.024790049,
-0.0041085375,
-0.018602453,
0.013631222,
0.000055209504,
0.014358397,
-0.011224934,
0.0010362241,
-0.019210635,
0.02557011,
0.001857601,
-0.011291041,
0.014847587,
-0.006333031,
-0.023507576,
-0.0031285041,
-0.0188801,
0.048363734,
0.0009949073,
0.010299439,
-0.032313004,
-0.015045907,
-0.0020856694,
-0.026984794,
0.0138956485,
-0.015455769,
-0.008600494,
-0.014636045,
-0.027473984,
0.020149352,
-0.0030309965,
-0.017372867,
0.034957275,
0.007622114,
-0.018853659,
-0.007846877,
0.008633547,
-0.0044192392,
-0.00466714,
0.0037978354,
-0.009459883,
0.0108613465,
0.0069742673,
0.02471072,
-0.008547609,
0.00032289038,
-0.017914942,
0.017610852,
-0.020387337,
0.025927085,
0.014212961,
-0.0058702836,
0.0038672476,
-0.0080584185,
-0.015085571,
0.0037945302,
-0.03334427,
-0.0074965106,
-0.00816419,
0.03551257,
-0.02595353,
-0.015587983,
0.005969444,
0.031149523,
-0.0047795214,
-0.009506158,
0.0038275835,
0.00778077,
0.010742354,
0.0058207037,
0.021709472,
-0.012989986,
0.0035367135,
0.020175794,
-0.014186518,
0.046406973,
0.0029962906,
0.0047596893,
0.023930661,
0.020083245,
-0.022978723,
-0.111270964,
-0.037363563,
0.002693852,
0.012818108,
-0.033899564,
0.0090698525,
0.011773621,
0.02383811,
-0.0015741681,
0.018205812,
-0.018139705,
-0.019633718,
0.011224934,
0.002703768,
0.009803638,
-0.007132923,
0.027473984,
-0.010048233,
-0.03260387,
0.06436158,
-0.005804177,
-0.0054405895,
0.009902799,
-0.015244228,
-0.008983914,
-0.0013097409,
-0.034587078,
-0.008025365,
-0.0028012756,
-0.00963176,
0.0028607717,
-0.010636584,
0.028346594,
-0.015786303,
-0.009393776,
-0.00002409283,
-0.012494185,
-0.0188801,
0.024842935,
-0.021709472,
-0.005592635,
0.0041482016,
0.00607852,
0.012342139,
0.0051893834,
-0.023507576,
-0.03413755,
-0.0010701037,
0.016777905,
-0.007033763,
-0.0055860244,
-0.0046506133,
-0.014874029,
-0.015297113,
0.017663736,
-0.012031437,
0.01419974,
0.014675709,
-0.020929413,
0.0052191317,
0.014411282,
0.009664814,
-0.010808461,
0.032630317,
0.004601033,
-0.031387508,
-0.0027566534,
-0.03657028,
0.021246724,
-0.026998015,
-0.0007127139,
0.017835613,
0.018417353,
-0.0073312437,
-0.03609431,
0.045957446,
-0.0122562,
-0.006121489,
0.011793452,
-0.025940306,
-0.030673554,
-0.008626937,
0.040616017,
-0.0030871874,
0.020757534,
0.034375533,
0.0032210536,
0.010848125,
-0.039611194,
-0.021484708,
-0.0073378547,
0.016857233,
-0.015812745,
0.020453444,
-0.013578336,
0.028531693,
-0.020545993,
-0.000020490525,
0.03471929,
0.01827192,
-0.021973899,
-0.04170017,
-0.045878116,
0.0059958864,
0.011033225,
-0.025808094,
0.022780402,
0.0033119505,
0.009519379,
-0.00043919703,
-0.009413608,
0.02177558,
-0.0033069926,
0.0006912292,
-0.005913253,
-0.000014086429,
-0.022912616,
0.026760032,
0.030647112,
-0.014041084,
0.03006537,
0.034454864,
0.010352325,
-0.0046440023,
0.000050199847,
0.06108268,
0.020625321,
-0.014424503,
-0.007304801,
0.010841515,
-0.0005094355,
-0.0032342752,
0.0060917414,
-0.046671398,
0.0065445728,
0.016804349,
0.006809,
-0.015865631,
0.01712166,
0.02509414,
0.011363759,
0.03392601,
-0.015231006,
-0.031334624,
0.011416644,
-0.0045283157,
0.015905295,
0.01527067,
-0.026627818,
-0.0060058027,
-0.0032722864,
0.011403423,
0.014027863,
0.0045944224,
-0.0006404096,
0.006329726,
-0.030118257,
-0.0038176675,
-0.006835443,
0.0025864285,
-0.014345175,
-0.00894425,
0.034005336,
0.017835613,
0.007965869,
-0.019408956,
-0.011026613,
-0.0068023894,
-0.016209386,
0.030462012,
-0.0023616652,
-0.020942634,
-0.009955684,
0.0126792835,
0.032127902,
0.0030227334,
0.031942803,
0.021749137,
-0.015918517,
0.012778444,
-0.012659452,
0.021445045,
-0.006309894,
-0.009810248,
-0.045190606,
-0.013095756,
0.02325637,
0.000513154,
-0.007886541,
0.01167446,
-0.019104864,
0.003259065,
0.007040374,
0.028611021,
-0.016011067,
0.019131307,
0.0068817176,
0.033212055,
0.010345714,
0.0028475502,
0.021326052,
0.027606199,
-0.0037879194,
-0.0062999777,
-0.0068023894,
-0.030409127,
0.013313909,
0.00836251,
-0.037971742,
-0.016672134,
-0.011310873,
-0.005391009,
0.012831329,
0.01817937,
-0.013948535,
0.011443087,
-0.012996596,
-0.009499547,
-0.014041084,
-0.017663736,
-0.011165438,
0.028373037,
0.007866709,
0.009955684,
0.02383811,
-0.007846877,
0.0034111107,
-0.019567613,
0.025821315,
-0.036385182,
0.023071272,
-0.00063462526,
-0.004977842,
0.030699996,
-0.050426263,
-0.018139705,
0.017716622,
-0.0073180227,
0.0003619347,
0.00944005,
-0.0051232767,
0.06668854,
0.015402883,
-0.010484538,
-0.010768797,
0.004230835,
0.028663907,
0.0057347645,
0.01828514,
-0.01546899,
-0.019541169,
0.019990696,
-0.04550792,
0.024909042,
0.008051808,
-0.024300858,
0.006382611,
-0.0017534829,
0.003764782,
-0.0021055015,
0.0051563303,
0.026403055,
0.0131023675,
0.013188306,
-0.0031830424,
-0.004270499,
0.016394485,
0.03842127,
0.00826996,
-0.015204564,
-0.0036722326,
0.01623583,
-0.013373405,
-0.028240824,
0.020929413,
0.0077080526,
-0.023600126,
0.009426829,
-0.003313603,
0.02752687,
-0.0027070732,
0.0092615625,
-0.010636584,
-0.014940136,
-0.017293539,
-0.016711798,
-0.010709302,
-0.0020261733,
-0.020519549,
-0.044688195
] |
TNF expression of macrophages is under stringent translational control that depends on the p38 MAPK/MK2 pathway and the AU-rich element (ARE) in the TNF mRNA. Here, we elucidate the molecular mechanism of phosphorylation-regulated translation of TNF. We demonstrate that translation of the TNF-precursor at the ER requires expression of the ARE-binding and -stabilizing factor human antigen R (HuR) together with either activity of the p38 MAPK/MK2 pathway or the absence of the ARE-binding and -destabilizing factor tristetraprolin (TTP). We | [
-0.029011643,
-0.032197744,
-0.0062815384,
-0.025786687,
-0.010432535,
0.012595456,
-0.028234545,
-0.0018585583,
-0.012712021,
-0.023610814,
0.01999731,
0.0040311934,
0.009370501,
0.010477865,
-0.004468311,
-0.007557274,
0.025618317,
-0.0053814007,
-0.0012708782,
0.0076608867,
-0.025553558,
0.035642873,
-0.017303372,
-0.028571287,
0.0017678969,
0.028959835,
0.013612159,
-0.04077172,
-0.027276125,
-0.032612193,
-0.004134807,
0.0047597224,
-0.012472416,
0.010600906,
-0.0038207297,
-0.0056307195,
0.002734412,
-0.0064984784,
0.012394706,
-0.008573976,
0.027302027,
-0.0030403943,
0.00631068,
-0.015710322,
0.018171132,
-0.024232492,
0.018896421,
0.00070626836,
-0.007971725,
0.035953715,
0.0051774126,
-0.012504795,
-0.03175739,
-0.015762128,
-0.030306805,
-0.004811529,
-0.014233837,
0.03121342,
0.00047597225,
-0.011494568,
-0.012155101,
-0.008593404,
-0.031291127,
0.011157826,
0.0053134044,
0.018624438,
0.0077644996,
0.014842563,
-0.006304204,
-0.00394377,
0.027923705,
0.024750557,
-0.016422661,
0.012984005,
0.026084574,
-0.03654949,
-0.0016820924,
0.009875615,
-0.0048957146,
0.015800985,
0.021124102,
-0.0075248946,
0.004908666,
0.022807814,
0.02333883,
-0.034762163,
0.0023976697,
0.029089352,
0.019310875,
0.0013380649,
0.026343606,
0.022134328,
0.015269967,
0.027923705,
-0.011973778,
-0.01122906,
0.00029485187,
0.021046393,
-0.010736898,
-0.018637389,
-0.0144799175,
-0.001572813,
-0.004879525,
-0.0085480735,
-0.030410418,
0.014311546,
-0.0047564846,
-0.008917195,
-0.00041971361,
-0.026473124,
-0.017497648,
0.025825541,
-0.009493542,
-0.03209413,
0.027509253,
0.005125606,
0.0254888,
-0.007142822,
-0.013663965,
-0.004050621,
0.00581528,
0.036031425,
0.005297215,
0.0051644607,
0.0382332,
0.010555576,
0.0045784,
-0.0050640856,
-0.03600552,
-0.011144875,
0.02078736,
0.013068191,
0.022043668,
-0.00095761084,
-0.0183136,
0.016461516,
-0.041704237,
-0.014078418,
-0.023403589,
-0.04046088,
0.0024527141,
0.02287257,
-0.019492198,
-0.02046357,
0.015891645,
0.015580806,
0.022341555,
0.013910046,
0.009674865,
-0.00003640115,
-0.0011980254,
-0.031394742,
0.036212746,
-0.011876641,
-0.010167026,
0.004646396,
0.00081999984,
0.033156164,
0.010607381,
-0.020683747,
0.013663965,
-0.008839484,
0.024595138,
0.00025842543,
0.018417211,
0.026097527,
0.0092215575,
0.014272692,
0.015516048,
-0.022898475,
0.0049766623,
0.008807106,
-0.003012872,
0.0033139973,
0.011319721,
-0.005824994,
0.013638062,
0.0033479952,
-0.031731483,
0.00056784786,
0.0051579853,
-0.0033771365,
0.036679003,
0.012239287,
0.0005233266,
-0.0063074417,
0.012226335,
-0.0065599987,
0.0005812042,
-0.006122881,
0.011552851,
0.0034677978,
0.0064952406,
-0.018663293,
-0.63908505,
-0.023183411,
0.024724655,
-0.0013623491,
-0.017329276,
0.012407658,
-0.014091369,
-0.011798931,
-0.025838494,
0.046392724,
-0.014790757,
0.014725999,
0.0033868502,
-0.024051169,
-0.015075693,
-0.011203157,
-0.03074716,
-0.019621713,
0.023170458,
0.00756375,
-0.01003751,
0.0018585583,
0.0136251105,
-0.0069485474,
-0.00007437066,
0.01729042,
0.029296579,
-0.024569234,
-0.0005221124,
0.03121342,
-0.02437496,
0.011235535,
0.007583177,
-0.004782388,
0.039450653,
-0.007375951,
-0.014311546,
0.02740564,
0.03175739,
0.028130932,
-0.02030815,
-0.021175908,
0.007311193,
-0.015295871,
-0.01727747,
0.03066945,
0.004843908,
-0.009292792,
0.017899146,
-0.008826533,
-0.00581528,
0.01927202,
-0.015788032,
0.001248213,
-0.00872292,
0.017018437,
0.009888566,
-0.008697017,
-0.009707244,
-0.002038262,
-0.009351074,
0.021564458,
-0.0017468506,
0.0006107501,
-0.019466294,
-0.01147514,
-0.003914629,
0.0191166,
0.0038628224,
0.030099578,
0.0137934815,
0.03864765,
-0.0030970576,
0.007311193,
0.0081271455,
0.026602639,
-0.012129198,
0.0058768005,
0.0075378465,
0.0013607302,
-0.0010110363,
0.0058282316,
-0.024672847,
0.013314271,
0.013262465,
-0.007751548,
-0.03647178,
0.03074716,
0.011701794,
-0.0005439683,
-0.018171132,
-0.027146608,
-0.043258432,
-0.03066945,
-0.020735553,
0.015593758,
0.010659188,
0.012498319,
0.011118971,
-0.029581513,
-0.005225981,
-0.0034095156,
0.010613858,
-0.006398103,
0.029529708,
0.02276896,
-0.04685898,
-0.0074212817,
0.049190275,
-0.014997982,
0.0027878375,
0.00692912,
-0.031083902,
-0.024957784,
0.0045104036,
-0.021085247,
0.020968683,
0.012271666,
0.009104993,
-0.013715772,
0.032871228,
0.00569224,
0.01656513,
-0.0072529106,
0.02030815,
0.04237772,
-0.0005937511,
-0.020839166,
-0.009694292,
0.009240985,
0.009182703,
0.0076608867,
0.02756106,
-0.031006193,
0.040279556,
0.019777132,
0.010898793,
0.020567182,
0.01226519,
-0.045227077,
-0.024465622,
-0.0049021905,
0.016759405,
-0.029167062,
-0.00968134,
-0.0136251105,
-0.011798931,
0.0039955764,
-0.0017565642,
0.0045848754,
0.007790403,
0.0043582222,
-0.008386178,
-0.009454687,
0.02326112,
-0.0098950425,
-0.020087972,
-0.024426766,
-0.002530424,
-0.014648289,
0.0017063767,
0.014855515,
-0.030954385,
0.017122049,
-0.0066215186,
-0.007958774,
0.007162249,
0.025760785,
-0.0015396245,
-0.03696394,
-0.006025744,
0.0006856267,
-0.02748335,
0.01783439,
0.0037138788,
0.0020350243,
-0.008703493,
-0.023403589,
-0.009240985,
-0.022121377,
0.0033350438,
-0.007984677,
-0.00839913,
-0.019453343,
0.010212357,
0.03455494,
-0.0021062582,
0.014169079,
0.014648289,
0.027664673,
-0.025203865,
0.00059213216,
-0.006676563,
0.042015076,
0.01289982,
-0.029011643,
0.0066636116,
0.016176581,
0.0026178474,
0.014311546,
-0.0041736616,
-0.021655118,
0.030177288,
-0.018352455,
0.024595138,
-0.0019524576,
-0.031420644,
-0.03577239,
0.029736932,
-0.004115379,
-0.0017711349,
-0.01521816,
-0.0057699494,
-0.011106019,
-0.011682367,
0.009972752,
0.018352455,
-0.0010142742,
-0.014868466,
-0.0051709367,
0.003879012,
-0.016189532,
0.0046593472,
0.005271312,
-0.0071816766,
0.009920945,
-0.018987084,
0.017135002,
0.007978202,
-0.0017144715,
-0.01317828,
-0.004497452,
-0.0029821119,
0.009331646,
-0.0032152412,
0.01585279,
0.0013639681,
-0.010464914,
0.046030078,
0.008904243,
0.014687144,
-0.0003043632,
-0.010205882,
0.005394352,
0.0029675413,
-0.011501044,
0.010426059,
0.006326869,
-0.0027279363,
0.0016675219,
-0.010283591,
0.016850065,
0.002046357,
-0.0110865915,
-0.002078736,
-0.0058411835,
0.0159305,
-0.014687144,
0.044501785,
0.008813581,
0.016513323,
-0.00081069086,
0.0044877385,
-0.030695353,
0.01370282,
0.01337903,
0.00920213,
-0.01840426,
-0.0042060404,
-0.00066498504,
-0.030306805,
0.007337096,
0.018728051,
-0.004092714,
0.005640433,
0.015205209,
0.026252946,
-0.0009972752,
0.01855968,
0.02245812,
-0.0022713915,
-0.026486075,
0.041237976,
0.03082487,
-0.01039368,
-0.011727697,
-0.016837114,
-0.011235535,
-0.00733062,
0.0044067907,
-0.0040279557,
-0.0031731483,
0.0023377684,
0.013340175,
-0.028001415,
0.0054850136,
0.046703562,
-0.01736813,
0.016474469,
-0.018274745,
0.001970266,
-0.007926395,
-0.00848979,
-0.0004962092,
0.03455494,
-0.004193089,
0.0078098304,
-0.0013550639,
-0.012511271,
-0.029167062,
0.008301992,
-0.0018472257,
0.012919247,
-0.025514703,
0.0031650537,
-0.009176227,
-0.006152022,
0.0036458827,
0.031446546,
0.004338795,
0.009888566,
-0.0146353375,
0.018909374,
-0.0008268804,
0.020010263,
0.013404933,
0.01385824,
0.013217134,
-0.016629888,
0.00046544906,
-0.0045460206,
-0.036497682,
0.02572193,
-0.010419583,
-0.0055238684,
-0.0015428624,
0.01246594,
-0.007447185,
0.024569234,
0.017601259,
0.01190902,
-0.031498354,
-0.010348349,
0.0053554974,
0.021577409,
-0.008327896,
0.020424714,
0.016228387,
0.02134428,
0.009338123,
0.008276089,
0.019129552,
0.00511913,
-0.043180723,
0.0063495347,
0.007615556,
0.00760908,
0.0047661983,
0.010264164,
-0.014751902,
0.015541951,
0.02875261,
0.013184755,
0.012712021,
0.00887834,
0.02493188,
0.014454015,
-0.00733062,
-0.008425033,
-0.027379738,
0.010374253,
0.003836919,
-0.00595451,
-0.0057667117,
0.02247107,
-0.010549099,
-0.03035861,
-0.024556283,
-0.0060969777,
-0.0021645406,
0.007168725,
0.010931172,
-0.0066571357,
-0.021771682,
-0.005821756,
-0.021655118,
0.022108426,
-0.007304717,
0.009888566,
0.0018391309,
0.00963601,
0.00071962475,
-0.012129198,
-0.0009924184,
0.016137727,
-0.02493188,
-0.031524256,
0.002770029,
0.01425974,
0.025424043,
-0.004989614,
-0.004280512,
0.005569199,
0.01727747,
-0.0223027,
0.0020981634,
-0.0024850932,
-0.030980289,
-0.009208606,
-0.009176227,
0.008088291,
-0.020916875,
-0.020126827,
-0.014855515,
0.025980962,
-0.0039923387,
0.035953715,
0.009992179,
-0.024556283,
0.00422223,
0.013715772,
0.027690576,
0.012524222,
0.004915142,
-0.0076414593,
-0.025048444,
-0.016850065,
-0.024815315,
-0.0060840263,
0.0011340767,
0.011183729,
0.00012526651,
-0.0004435932,
-0.013009909,
0.00011626108,
0.0017954191,
-0.009467639,
0.013301319,
0.018054567,
0.013262465,
0.008289041,
0.016461516,
0.009376978,
0.0041704234,
-0.025760785,
-0.023248168,
0.030280901,
0.0019961693,
-0.010503769,
0.014933225,
-0.009215082,
-0.00064393866,
-0.020774407,
-0.008735872,
-0.017950954,
0.040098235,
0.019867795,
-0.023274072,
-0.018987084,
-0.014829611,
-0.016616937,
-0.0062847766,
0.00029424476,
-0.008936622,
-0.026732156,
-0.01214215,
-0.007751548,
0.004665823,
0.014078418,
-0.029244771,
-0.0286749,
0.050381824,
0.014609434,
0.005756998,
-0.014570579,
-0.011494568,
-0.024478573,
-0.018287696,
-0.008573976,
-0.045175273,
0.015645564,
-0.020100923,
0.033026647,
-0.002455952,
0.029167062,
-0.021318376,
0.0144669665,
0.026991189,
-0.002454333,
-0.008994904,
-0.012925723,
0.021214763,
-0.022807814,
0.011863689,
0.023053894,
0.003250858,
0.017899146,
-0.019764181,
0.00651143,
0.019971408,
-0.021564458,
-0.012161577,
0.009461163,
-0.025501752,
-0.025398139,
0.029192965,
-0.02683577,
0.00054356357,
-0.020217488,
-0.005510917,
0.0065567605,
-0.008638735,
0.014674192,
0.014285644,
0.016578082,
-0.021862345,
0.0040732864,
-0.029218867,
0.008314944,
-0.019466294,
0.001903889,
-0.0031472452,
0.025903253,
0.02836406,
-0.002559565,
0.001040987,
0.0010426058,
0.0061423085,
0.00032318354,
0.0048989523,
-0.016914824,
-0.016837114,
-0.016306097,
-0.02142199,
-0.020049118,
-0.025087299,
-0.015023886,
-0.024724655,
0.005721381,
0.0012571171,
-0.00559834,
0.01783439,
-0.02135723,
-0.02779419,
0.028959835,
0.0013753008,
0.03608323,
-0.0059706997,
0.01688892,
0.019414488,
0.0019103648,
-0.043595172,
-0.021551505,
-0.006916168,
0.0036847375,
0.04084943,
0.019880746,
0.00073014793,
-0.017588308,
0.013922998,
0.008943098,
-0.023118652,
-0.03359652,
0.05232457,
-0.009208606,
0.005229219,
0.007168725,
-0.00096084876,
-0.016953679,
0.023015039,
-0.016422661,
0.012452988,
-0.013353126,
0.0030225858,
-0.015658516,
0.020023214,
-0.0054526348,
0.012498319,
0.0027845996,
-0.050355922,
-0.022173183,
-0.009823808,
0.012284617,
-0.010173502,
-0.0047629606,
0.031239321,
0.0064175306,
0.018015712,
0.014156127,
-0.0035487455,
-0.024608089,
-0.012925723,
0.00042416574,
0.039010298,
-0.011883117,
0.0011688842,
0.022082523,
0.006993878,
0.00019002464,
-0.0074925157,
-0.00040291698,
-0.0127444,
-0.020049118,
0.010205882,
0.040175945,
0.012297569,
-0.02683577,
0.0119284475,
-0.019051842,
0.0029983015,
0.0060840263,
-0.0144669665,
0.029167062,
-0.04388011,
-0.0033641849,
0.008166,
0.022419265,
0.016254291,
0.010419583,
0.009946849,
-0.02222499,
0.0382332,
-0.031342935,
0.0070456844,
0.008975477,
-0.00569224,
0.013417885,
-0.0023814803,
-0.016241338,
-0.032534484,
0.020217488,
-0.0153217735,
-0.024025267,
0.008988429,
0.0036167416,
0.017678969,
0.011669415,
-0.024556283,
0.022743056,
0.0038272054,
0.0044165044,
-0.004908666,
0.018443115,
0.017510599,
-0.009940373,
0.011293818,
0.0052097915,
-0.022250893,
-0.017160904,
0.019660568,
-0.013230086,
0.010587954,
-0.0018650341,
-0.0012724972,
-0.009506494,
0.007278814,
-0.043931916,
-0.0034839874,
0.016034113,
-0.0055432958,
-0.008114194,
0.016940726,
0.0054493966,
-0.016202483,
-0.011624084,
0.008612831,
-0.008768251,
-0.00900138,
-0.015645564,
-0.0013243038,
0.004503928,
-0.01880576,
-0.03256039,
0.0009988941,
-0.029607417,
0.034036875,
-0.0037074029,
-0.018766906,
-0.027820092,
0.010924697,
-0.03654949,
-0.029529708,
-0.021771682,
0.0067672245,
0.010380728,
0.0076673627,
-0.008619308,
-0.0015970974,
-0.0037915886,
0.015464242,
0.0016132869,
-0.0195181,
-0.008483315,
0.0063236314,
-0.0032605717,
0.008599879,
-0.03408868,
-0.018248841,
0.04214459,
-0.019738277,
0.006058123,
0.027742382,
-0.02191415,
-0.0052842633,
-0.008088291,
-0.014285644,
-0.02118886,
0.015399483,
0.0358501,
-0.01583984,
0.0055886265,
0.022199087,
0.020178633,
-0.015269967,
0.015865741,
0.020903924,
0.015956404,
-0.008729395,
-0.0090531865,
-0.0040085283,
0.014233837,
-0.010128171,
0.049578823,
0.030306805,
0.0064240065,
-0.0023571958,
0.024258396,
-0.023364734,
0.008386178,
-0.0045622103,
-0.01656513,
-0.004678775,
-0.0003391707,
0.026602639,
-0.0037138788,
-0.00041768994,
-0.010270639,
-0.007550798,
-0.025177961,
0.005232457,
-0.012006157,
-0.013074666,
0.0005427541,
-0.0022649155,
-0.0032524772,
-0.0034904631,
-0.0071169185,
-0.031446546,
-0.012530698,
-0.004154234,
-0.011209632,
-0.0002592349,
-0.004950759,
-0.008172476,
-0.015619661,
0.00218073,
-0.0008402367,
-0.020618988,
-0.017886195,
0.046055984,
0.18826483,
-0.026809866,
-0.0142985955,
0.0006338202,
-0.006054885,
0.004215754,
0.006475813,
-0.0006338202,
-0.019725326,
-0.0022681535,
0.016513323,
0.026188187,
-0.012873916,
0.0011373147,
0.0029351623,
-0.019945504,
-0.030928483,
0.0024073834,
-0.027768286,
-0.0041704234,
0.01585279,
0.000025169664,
0.011539899,
0.000779526,
0.03761152,
0.005993365,
-0.026006864,
0.021072295,
0.018831665,
-0.02039881,
-0.031731483,
0.010374253,
0.016629888,
0.00014014063,
0.0036814997,
0.00740833,
-0.010283591,
0.0064628613,
0.013547401,
-0.0074148057,
0.004018242,
0.009538872,
-0.0068060793,
-0.007097491,
0.005847659,
0.007498991,
-0.018624438,
-0.019064793,
-0.02994416,
0.016241338,
-0.043051206,
-0.0026129906,
0.0059318445,
0.021150006,
-0.0070780637,
-0.013547401,
0.005611292,
0.036186844,
-0.002838025,
0.008671113,
-0.011999682,
0.00145382,
-0.032456774,
0.009104993,
-0.026162285,
0.028079126,
-0.01262136,
-0.018494923,
0.019686472,
-0.022587636,
-0.008658162,
-0.0035843626,
0.00093656447,
-0.005650147,
0.0054202555,
0.00644991,
0.019984359,
0.010277115,
0.021305425,
0.03911391,
-0.0047856257,
-0.01115135,
-0.02276896,
-0.0126148835,
-0.009092041,
-0.024193637,
0.012802682,
0.0142985955,
-0.008140097,
-0.019971408,
0.014777806,
-0.015049789,
-0.00092927914,
-0.026991189,
-0.0027684101,
-0.0031634346,
0.005656623,
-0.013884143,
-0.019310875,
-0.016422661,
-0.018857567,
0.06076903,
0.00887834,
0.021370184,
-0.0018763668,
-0.0093057435,
-0.0011081735,
0.011675891,
0.002078736,
-0.005540058,
0.0094741145,
-0.010354825,
-0.0017177094,
-0.012750876,
0.00064312917,
0.00657295,
-0.01198673,
-0.00644991,
0.02524272,
-0.0126019325,
0.0049604727,
-0.008178952,
0.000015822738,
0.018171132,
-0.011501044,
0.023455394,
-0.021525603,
0.007168725,
-0.0037171165,
-0.027120706,
0.0070068296,
-0.0016869493,
0.0014546295,
0.0110024065,
-0.00511913,
-0.009098518,
0.001370444,
-0.023856895,
-0.011773028,
0.026421318,
0.015813936,
-0.0025239482,
0.0025579461,
0.00748604,
0.0010507007,
-0.0014586769,
0.008412081,
0.0120255845,
-0.019945504,
-0.003807778,
0.01266669,
-0.015360628,
-0.024905976,
-0.004986376,
0.012912771,
-0.023934605,
-0.027768286,
-0.023092749,
-0.005025231,
0.018287696,
-0.0318869,
0.020191586,
0.030850774,
-0.02143494,
0.009616583,
0.0055238684,
-0.16153269,
0.008321419,
0.0032233358,
-0.007583177,
0.050848085,
0.0318869,
0.010730422,
0.014454015,
-0.016850065,
0.0061811637,
0.022574684,
0.01043901,
-0.035901908,
-0.02222499,
-0.0041671856,
0.0043161293,
-0.007939347,
0.026576737,
-0.012342899,
0.019582858,
0.027820092,
-0.013314271,
0.011513996,
-0.017303372,
-0.01322361,
0.014570579,
-0.0042189923,
-0.008515694,
0.0051353197,
-0.01393595,
-0.027302027,
0.012310521,
0.028182738,
-0.004076524,
0.023222266,
0.005044658,
-0.005271312,
-0.019466294,
-0.029581513,
0.0223027,
0.021305425,
0.019051842,
0.004267561,
0.00088071055,
-0.0183136,
0.028623093,
0.009422308,
0.011080116,
0.0146353375,
-0.0097266715,
-0.0047597224,
-0.018132277,
-0.012951626,
0.04292169,
0.02986645,
0.004915142,
0.0053619733,
0.01744584,
-0.007751548,
0.00061722595,
-0.028415868,
0.01142981,
0.01393595,
0.000047025533,
-0.0035001768,
-0.04191146,
-0.022199087,
0.013340175,
-0.008787679,
-0.0058929897,
-0.02844177,
-0.015438338,
0.0142985955,
-0.00927984,
0.0077126934,
-0.004507166,
-0.005918893,
0.0146353375,
0.014622386,
0.0013024479,
-0.023015039,
0.012329948,
-0.03201642,
-0.0056630983,
0.0053166426,
-0.0052389326,
0.0038272054,
0.02596801,
-0.013832336,
0.0018634152,
0.002873642,
-0.009668388,
0.006689515,
-0.005656623,
0.03289713,
0.0051644607,
-0.0020835928,
-0.0028768799,
-0.00003432687,
-0.0015857647,
0.05351612,
-0.022924379,
-0.024698751,
0.005148271,
0.03678262,
0.0046172547,
-0.007388903,
0.0080429595,
0.05377515,
-0.0057602357,
0.009228034,
-0.0047370573,
0.006715418,
0.020541279,
-0.015114548,
0.01775668,
0.019155456,
-0.0063592484,
-0.004542783,
-0.013048763,
0.0716484,
0.005960986,
0.002145113,
0.0060160304,
-0.007440709,
-0.046340916,
-0.13107045,
-0.013443788,
-0.008340847,
0.010458438,
-0.02683577,
0.008314944,
-0.004847146,
0.029918255,
-0.0036426447,
0.017601259,
-0.03800007,
0.008638735,
0.006683039,
-0.0053263563,
0.0013550639,
-0.014363353,
0.036523584,
0.008936622,
-0.027250221,
0.044113237,
-0.0132883685,
0.0029659222,
0.018598534,
0.0110865915,
-0.0023701475,
0.010283591,
-0.03991691,
0.004403553,
-0.005093227,
0.012595456,
-0.008088291,
-0.013884143,
0.016707597,
0.010840511,
-0.016733501,
-0.016668743,
-0.0061908774,
-0.015399483,
0.026991189,
0.014687144,
0.0011866927,
0.018520825,
0.028234545,
-0.01067214,
0.0016019542,
-0.022963233,
-0.04587466,
0.0005083513,
0.0035163665,
-0.0073953783,
-0.015813936,
-0.032404967,
-0.040642202,
-0.011410383,
0.016357904,
-0.008833009,
0.002146732,
0.017769631,
-0.015697371,
0.0038660604,
0.0054753,
-0.009208606,
-0.0007467422,
0.021020489,
0.036575392,
-0.011526947,
-0.0021240667,
-0.03204232,
0.016267242,
-0.010782229,
-0.009590679,
-0.0008928527,
0.0028202166,
-0.013301319,
-0.026123429,
-0.0071492977,
-0.02851948,
-0.01051672,
0.0019864556,
-0.023027992,
-0.0062426836,
-0.017549453,
0.010827559,
-0.0382332,
0.029115256,
0.0055012032,
0.0060095545,
-0.010562051,
0.019323826,
-0.022756007,
0.0120126335,
0.04372469,
0.012860965,
-0.015295871,
-0.019051842,
0.015541951,
0.009389929,
0.0036199794,
0.010568527,
0.015917549,
-0.011831311,
-0.019764181,
-0.05162518,
0.0017776106,
0.0024462384,
-0.0040441453,
-0.004076524,
-0.03281942,
0.012459464,
-0.020994585,
0.0136251105,
0.003772161,
-0.019284971,
0.0071104425,
-0.0086322585,
0.012524222,
-0.035979617,
-0.004251371,
0.011021834,
-0.0022730103,
0.014933225,
0.018054567,
-0.025501752,
-0.005387876,
-0.019310875,
-0.0032719045,
-0.012627835,
-0.0030387752,
-0.01823589,
0.020450618,
-0.012064439,
0.0058670864,
0.0044812625,
-0.038518135,
0.009985704,
0.021396086,
-0.0057667117,
-0.018818712,
-0.0016659029,
0.022173183,
0.023222266,
0.02763877,
-0.025838494,
-0.04349156,
-0.009590679,
-0.008904243,
0.033492904,
-0.0077709756,
-0.032948937,
-0.0064628613,
0.009189178,
-0.017419936,
0.02095573,
0.012148625,
0.011714745,
-0.023999363,
-0.027612867,
0.0012498319,
-0.014531724,
-0.026343606,
-0.007673838,
-0.033156164,
0.02278191,
0.01832655,
0.0016610461,
0.0001627048,
0.015334725,
-0.002251964,
-0.0398392,
0.012854489,
0.011617608,
-0.013275417,
-0.0025806115,
0.0062944903,
0.009117945,
-0.002389575,
-0.004847146,
0.012517747,
-0.023792136,
0.0016319049,
-0.0121810045,
0.001122744,
0.00045411638,
-0.022147281,
-0.03654949,
0.016072968,
0.009778477,
0.0023992888,
-0.010361301,
0.010970027,
-0.0053101666,
0.011863689,
-0.020748505,
0.009143848,
0.009422308,
0.027042994,
0.03066945,
0.019207262,
0.006566474,
-0.017717825,
-0.005656623,
0.024426766,
0.007725645,
-0.014648289,
-0.014389256,
-0.0069355955,
-0.022976184,
0.013366078,
-0.05393057,
-0.02732793,
0.0023312927,
0.0014821517,
-0.016953679,
0.009234509,
-0.0039308183,
0.00083376095,
-0.019932553,
0.004928094,
-0.016642839,
-0.001730661,
0.0036135036,
0.009370501,
0.031809192,
0.03362242,
0.0058347075,
-0.0025207102,
-0.010736898,
0.005948034,
0.0144669665,
-0.0144799175,
0.026460173,
-0.015878694,
0.006501716,
0.015399483,
-0.0117600765,
-0.012964577,
-0.018015712,
-0.00011292199,
-0.0010539385,
0.048283663,
-0.0029756362,
0.08812286,
0.018520825,
-0.012051488,
0.004115379,
-0.0018229414,
0.017497648,
-0.0039664353,
0.011242012,
-0.0069485474,
-0.03305255,
0.014039563,
-0.00035050337,
0.015088644,
-0.051728792,
-0.010400156,
0.017173856,
0.0038854878,
0.0008969001,
0.007932871,
-0.0041315686,
0.024802364,
0.012342899,
-0.0063203936,
0.036368165,
-0.052065536,
0.0144669665,
0.047661982,
0.021693973,
0.014000707,
-0.030462224,
-0.0051288437,
-0.015736226,
-0.014117273,
0.005235695,
0.015166354,
-0.007900492,
-0.027379738,
-0.023584912,
0.012718497,
0.024336105,
0.0067737005,
0.0022341555,
-0.0024413816,
-0.010691567,
0.023222266,
-0.0070456844,
-0.008703493,
0.016111823,
-0.02851948
] |
AIMS Tumor microenvironment is a strong determinant for the acquisition of metastatic potential of cancer cells. We have recently demonstrated that cancer-associated fibroblasts (CAFs) elicit a redox-dependent epithelial-mesenchymal transition (EMT) in prostate cancer (PCa) cells, driven by cycloxygenase-2/hypoxia-inducible factor-1 (HIF-1)/nuclear factor-κB pathway and enhancing tumor aggressiveness. Here, we investigated the involvement of microRNAs (miRNAs) in tumor-stroma interplay to identify possible tools to counteract | [
-0.028230943,
-0.04083919,
-0.0035321445,
-0.030065823,
-0.02030164,
0.0019299008,
-0.020537551,
0.001879114,
-0.018506078,
0.0037811638,
0.02382723,
-0.005891276,
0.021664694,
-0.0076344125,
-0.033106484,
-0.002090453,
0.025177179,
0.007876879,
-0.035072424,
0.007031523,
-0.03654033,
0.02386655,
-0.003787717,
-0.0005344908,
-0.014456235,
0.02849307,
0.018335696,
-0.03554425,
0.0077261566,
-0.03879461,
0.0016587646,
0.0070839482,
-0.020327851,
-0.00714948,
-0.0053080465,
0.010163926,
0.004180906,
-0.013971303,
0.036435477,
-0.012385442,
0.00426282,
-0.0042267777,
0.0013302881,
0.010432605,
-0.022896685,
-0.009777291,
0.0074116057,
-0.014665935,
-0.012044678,
0.019357987,
0.015714439,
0.0031848277,
-0.005593108,
-0.0031471474,
-0.015059124,
-0.0056357034,
-0.002051134,
0.03530834,
0.008807425,
0.0055308533,
-0.019043436,
0.0065662498,
-0.01747068,
0.018873055,
-0.016015884,
0.027130015,
0.021219078,
0.020707933,
0.017274087,
0.013578114,
0.0393975,
0.045478817,
-0.020734146,
-0.010747156,
0.00804726,
-0.0134863695,
-0.028283369,
-0.0025295136,
-0.01990845,
0.013905771,
0.01394509,
-0.018375015,
-0.009292358,
0.025504835,
-0.0015514567,
0.0138664525,
-0.017129917,
0.013473263,
0.02630432,
-0.0014105642,
0.014482448,
0.012791736,
0.016186265,
0.017444469,
-0.019318668,
0.01941041,
0.0030111696,
0.011356598,
0.023945186,
-0.051088307,
0.0052916636,
0.020065727,
-0.0011132152,
-0.015308144,
-0.039135374,
-0.009436527,
0.012582036,
-0.0029358084,
0.022070987,
-0.0020429424,
-0.011808765,
0.023420935,
-0.0034797194,
-0.027261078,
0.0078506665,
-0.0015793076,
0.027942605,
0.019672537,
-0.014692148,
-0.004528222,
-0.0026081512,
0.037641257,
0.004390606,
-0.013696071,
0.010544009,
0.0039449926,
-0.017523106,
-0.005655363,
-0.022922896,
-0.004282479,
0.010196691,
-0.002097006,
0.026658189,
0.0003720957,
-0.026396062,
0.009914907,
-0.027837755,
-0.01775902,
-0.026002875,
-0.019135179,
-0.0101115005,
0.021913713,
-0.014731467,
-0.01415479,
-0.0302231,
0.0030406588,
0.016776048,
-0.006628505,
0.021913713,
0.021415673,
0.004318522,
-0.040865403,
0.0077196034,
-0.00061312853,
-0.010878218,
0.0046199663,
-0.0004853422,
0.028624132,
-0.015163975,
-0.011782552,
0.01807357,
-0.012837608,
0.026396062,
0.021337036,
0.03276572,
0.014587298,
0.013158713,
0.020000195,
-0.0032552741,
-0.024456332,
0.010412945,
-0.0012123316,
-0.030590074,
0.02217584,
0.004577371,
0.022110308,
-0.023093278,
0.030196887,
-0.030694924,
-0.043250747,
-0.013053862,
0.0077327094,
0.028335793,
-0.012981778,
-0.012391995,
-0.0111993225,
0.011409023,
-0.005822468,
-0.013565008,
-0.03570153,
-0.012962118,
0.023460254,
-0.006874248,
-0.0042235013,
-0.6295212,
-0.02707759,
0.022739409,
-0.0043578404,
0.008761553,
0.006703866,
0.0057962555,
-0.0018201356,
-0.0052687274,
0.004233331,
-0.021717118,
0.02011815,
0.0038303125,
-0.010203245,
0.009108869,
-0.021061804,
-0.016959535,
-0.021979244,
-0.0020019854,
0.0051671537,
-0.0214681,
0.013021097,
-0.00241811,
0.012785183,
-0.005946978,
0.02220205,
0.02901732,
-0.008433896,
0.0027244694,
0.03656654,
-0.02290979,
0.023630636,
-0.0017283916,
-0.008741894,
0.05882102,
0.0061435723,
-0.013669858,
0.033447247,
0.018689565,
0.008990913,
0.018047357,
-0.014416916,
0.013099735,
0.0002801469,
-0.009154742,
0.02707759,
0.00702497,
0.000050018916,
-0.0039286097,
-0.0032618272,
-0.004020354,
0.0152295055,
-0.047470972,
0.003673037,
0.028991107,
0.006395868,
0.039659627,
-0.012824502,
0.010661965,
0.007981729,
0.0032274232,
0.02859792,
-0.022293795,
-0.021441886,
0.00737884,
0.014836317,
-0.0038008234,
0.008977807,
0.0069987574,
0.02301464,
0.017890083,
0.027261078,
-0.018099783,
0.014272747,
0.038532484,
0.042674072,
0.0021117507,
0.025046116,
-0.0145741915,
0.006022339,
0.015753757,
-0.0035026553,
-0.02993476,
0.013709176,
0.020983167,
0.024010718,
-0.02128461,
0.016068308,
0.0064384635,
0.000979695,
0.0011525342,
-0.0016014245,
-0.026094617,
-0.056828864,
-0.012123316,
0.020039514,
-0.0025884917,
0.018296378,
0.01415479,
-0.02941051,
-0.005478428,
-0.0075426684,
0.0053145997,
-0.004452861,
0.025111647,
-0.002842426,
-0.032136615,
0.00030246854,
0.017732807,
-0.037850957,
0.018519184,
0.014993593,
-0.0033306354,
-0.031166751,
-0.03195313,
-0.028781407,
0.01048503,
0.032608442,
0.0049509,
-0.01786387,
0.023316085,
0.0029177873,
0.0063074008,
0.0070577357,
0.028860046,
0.014089259,
-0.0060780407,
-0.03979069,
-0.02672372,
-0.0055046408,
0.00048165605,
-0.015806183,
0.016749835,
-0.023840336,
0.01623869,
0.00829628,
0.00829628,
-0.0036435479,
-0.0050229845,
-0.03800823,
-0.02901732,
-0.019882238,
0.016225584,
-0.0129686715,
-0.015911033,
-0.014325172,
-0.020432701,
0.008335599,
0.013630539,
-0.0033502947,
-0.0155833755,
-0.006854588,
-0.0071298205,
0.009810057,
0.032346316,
-0.018558502,
-0.004423372,
-0.014128578,
-0.0023869826,
-0.020196788,
-0.028440643,
0.025229603,
-0.017994933,
0.0007003672,
-0.007103608,
0.0009305464,
-0.0241811,
0.011146897,
-0.004164523,
-0.03268708,
-0.00908921,
-0.01394509,
-0.017811444,
0.019790495,
-0.019777387,
0.0007577072,
-0.015019805,
-0.0027261078,
-0.02880762,
-0.016120734,
0.0156095885,
-0.017418256,
0.009357889,
0.010013203,
0.016933324,
0.028414432,
0.024456332,
0.0019577516,
0.0025393432,
0.032215256,
-0.049227215,
-0.0015055848,
-0.005891276,
0.024128675,
0.019751174,
-0.02820473,
0.021245291,
0.008276621,
-0.0024000888,
0.025268922,
0.0047117104,
-0.023355404,
0.03218904,
-0.0017431362,
0.015399887,
0.010445711,
-0.004279203,
-0.013931983,
0.021337036,
0.0012991608,
-0.009200614,
0.0069528855,
-0.01321769,
-0.0059174886,
0.0009895246,
0.0022100478,
0.00019423927,
0.0009608547,
-0.013787814,
-0.016972642,
-0.031612366,
0.003558357,
0.02015747,
-0.023420935,
0.0058322977,
-0.0018594546,
0.007817901,
0.005914212,
0.0104653705,
-0.009842821,
0.01817842,
0.0044430313,
0.02138946,
-0.004469244,
0.023316085,
-0.006834929,
0.0020085385,
-0.005088516,
0.045898218,
-0.0027342993,
0.0053080465,
0.0064450167,
0.006051828,
-0.009980438,
-0.008230749,
-0.0141941095,
0.03287057,
0.020354064,
0.004829667,
0.0016743282,
-0.017929401,
0.013617433,
0.0138140265,
0.0074509243,
0.00071101607,
-0.018414333,
-0.0050983457,
0.008394577,
0.05082618,
0.010602986,
0.013643645,
-0.0033355502,
0.010091841,
-0.017025067,
-0.0054292795,
0.027470779,
0.026527125,
-0.0067071426,
-0.00863049,
-0.010478477,
-0.012726205,
-0.0026278107,
0.01450866,
-0.038139295,
0.007444371,
0.007064289,
0.011212429,
0.010720943,
0.024403907,
0.011795659,
0.004996772,
-0.039659627,
0.04031494,
0.0017939231,
-0.021061804,
-0.0092399325,
-0.014364491,
0.0025295136,
-0.010170479,
0.0039974176,
0.034967575,
0.00679561,
-0.0026097894,
-0.0029603827,
-0.009862482,
-0.013178372,
0.008034154,
-0.044089552,
0.047392335,
0.0028342346,
0.0038892908,
-0.03003961,
-0.007758922,
-0.0063041244,
0.017536212,
0.0040891618,
0.00084535556,
-0.016304221,
-0.017837657,
-0.024377694,
-0.023565104,
0.006644888,
-0.0037549513,
-0.0039974176,
0.0007327234,
-0.009272698,
-0.002624534,
-0.019659432,
0.042490583,
-0.0055734487,
0.006038722,
-0.026500912,
0.0033076992,
-0.0064089745,
0.022241369,
0.030170674,
-0.0152819315,
0.0035714633,
-0.0043054153,
0.0046429024,
-0.0032110405,
-0.03502,
0.011074813,
-0.025780067,
-0.0061337426,
-0.014810105,
0.006694036,
-0.0044430313,
0.007523009,
0.04519048,
-0.016658092,
-0.026500912,
-0.028964896,
0.004652732,
-0.007169139,
0.0043414575,
0.043486662,
0.02849307,
0.03003961,
0.0062484224,
-0.011513873,
0.038847037,
-0.0013720645,
-0.028938683,
-0.0017971997,
0.02301464,
0.00065900054,
0.0054685986,
-0.0011500767,
-0.013761601,
0.01609452,
-0.0028981278,
0.01279829,
-0.0026917038,
-0.009770737,
0.010262223,
0.0058421274,
0.0074509243,
0.010045969,
-0.027575629,
0.0013671496,
0.0013352031,
0.0049017514,
-0.026081512,
0.010753709,
-0.009220273,
-0.008800872,
-0.024849521,
0.020209895,
0.00006481469,
-0.011454895,
-0.016369753,
-0.0014711807,
-0.03226768,
-0.010373627,
-0.007863772,
0.0074574775,
-0.015766865,
0.0145741915,
-0.010281882,
0.0016259988,
-0.01036052,
-0.017011961,
0.004216948,
0.009973885,
-0.035177276,
-0.02336851,
0.011625277,
0.019122073,
0.02311949,
0.0040301834,
-0.017300298,
-0.008840191,
0.021926818,
0.002491833,
-0.0069332263,
0.0035714633,
-0.042516798,
-0.006874248,
-0.010039416,
-0.0065662498,
-0.023656849,
-0.013971303,
0.004528222,
0.019253137,
-0.015308144,
0.006418804,
-0.0067562913,
-0.0066678235,
0.0051671537,
-0.0026507466,
0.00069750025,
-0.006926673,
-0.021939926,
0.0058978293,
-0.041809056,
-0.008145558,
-0.018479865,
-0.0015555525,
-0.0115531925,
0.018243952,
-0.0049246876,
-0.017641062,
-0.00015543238,
0.00033277684,
-0.0014638085,
-0.006834929,
-0.017011961,
0.019960877,
-0.0035288678,
-0.02157295,
0.014246535,
-0.004714987,
0.014010621,
0.00806692,
-0.0053211525,
0.02993476,
0.006543314,
-0.0012475548,
0.014954274,
0.00967244,
0.00019864217,
-0.031507514,
-0.008833637,
-0.032451168,
0.047497187,
0.0006954524,
-0.046946723,
-0.013971303,
-0.007916197,
-0.0075819874,
-0.00035673677,
-0.0061959974,
-0.006887354,
-0.026094617,
-0.004760859,
-0.0049083047,
-0.026553338,
0.022739409,
-0.0387684,
-0.0034764428,
0.026998952,
0.005160601,
0.0047805184,
-0.01290314,
0.0038663547,
-0.012994884,
-0.0029161489,
-0.008388024,
-0.038847037,
-0.009980438,
-0.016658092,
0.039528564,
0.024954371,
0.036199566,
0.0155833755,
0.027025165,
0.011232088,
0.010930643,
-0.0045052865,
0.0024656204,
0.02922702,
-0.018125996,
0.012660674,
0.032818142,
0.008846744,
0.023879655,
-0.014561085,
0.019174498,
0.0087222345,
-0.019253137,
-0.010635752,
0.009633121,
-0.026186362,
-0.048519477,
0.023578212,
-0.011540086,
0.014023728,
-0.04173042,
-0.011913615,
0.015950352,
0.028362006,
0.019672537,
-0.0034174644,
0.01990845,
-0.0021264951,
0.012182294,
-0.017339619,
-0.0026851506,
-0.0066776536,
-0.003787717,
0.0013630539,
-0.0124247605,
0.033761796,
0.0035976758,
0.014521766,
0.018322589,
-0.021101123,
0.0070446297,
0.0058486806,
-0.010196691,
-0.014875636,
-0.0010845453,
-0.029279446,
-0.015688226,
0.00011427044,
-0.020891422,
-0.031428877,
-0.0013761602,
0.00095757813,
-0.032110404,
0.0108389,
-0.00020447857,
-0.010045969,
0.039974175,
0.009502058,
0.021520523,
-0.03318512,
0.007758922,
0.00633689,
-0.0141941095,
-0.009895247,
-0.00040301835,
-0.0010648859,
0.010766815,
0.038296573,
0.02789018,
-0.006959439,
-0.01336186,
-0.00038643068,
0.0048493263,
0.0054128966,
-0.019607006,
0.03095705,
0.00921372,
0.0034404004,
-0.019987088,
-0.012149529,
-0.025780067,
-0.0017120088,
-0.016225584,
0.022149626,
-0.009187507,
-0.018034251,
-0.01849297,
0.02728729,
-0.008748447,
0.0111993225,
0.011448342,
-0.015819289,
-0.0046494557,
-0.022647664,
-0.0017955614,
0.006100977,
-0.010085288,
0.027759116,
-0.0051868134,
0.02086521,
0.012699992,
-0.016671197,
-0.011238641,
-0.008289726,
0.0005627512,
0.03900431,
0.0065007186,
-0.0018004762,
0.0241811,
0.0078244535,
0.031271603,
-0.032005552,
0.004321798,
-0.002989872,
-0.027392142,
-0.0032683804,
0.026081512,
0.018584715,
-0.018820629,
0.010924091,
-0.026422275,
0.018440546,
-0.010707837,
-0.0026671295,
0.014587298,
-0.019148286,
-0.014141684,
0.008106239,
0.03656654,
0.013905771,
0.013263563,
-0.00090842956,
-0.020485127,
0.03287057,
-0.02051134,
0.036199566,
0.009279251,
0.016972642,
0.0016595836,
0.015858607,
-0.013538795,
-0.035649102,
0.0059207655,
-0.02157295,
-0.034784086,
-0.017890083,
0.008833637,
0.010858559,
0.002332919,
-0.014285853,
0.019161392,
0.010753709,
0.0047117104,
-0.014679042,
0.020576872,
0.011992253,
-0.01233957,
0.004547882,
0.028178519,
-0.006854588,
-0.0013851707,
-0.010196691,
-0.011782552,
0.0069201197,
0.004760859,
-0.012876927,
-0.012025018,
0.011775999,
-0.016671197,
-0.02351268,
0.022673877,
-0.0093775485,
-0.011251748,
0.017195448,
0.005845404,
-0.00679561,
-0.0004079332,
0.007935857,
-0.0018610928,
-0.0038860142,
-0.033421032,
-0.002411557,
-0.011114132,
-0.02707759,
-0.022844259,
-0.0049246876,
-0.019371092,
0.01532125,
0.000046742345,
0.00001048247,
-0.013696071,
0.003248721,
-0.044902142,
-0.034181196,
0.005478428,
0.0065498673,
0.005072133,
-0.010144266,
-0.0015080422,
0.0063762087,
-0.0011533533,
-0.011422129,
-0.0072739897,
-0.0031274878,
0.00037230048,
-0.017195448,
0.015085337,
-0.00887951,
-0.037221856,
-0.01924003,
0.025609685,
0.0027981924,
-0.017994933,
0.017313406,
-0.0007900634,
-0.0022264305,
0.011933275,
-0.0075819874,
0.0027375757,
0.0058486806,
0.015871715,
-0.010222904,
-0.0018299654,
0.02153363,
0.0049377936,
0.007201905,
0.0075033493,
-0.0066711004,
0.028728982,
0.0015227868,
0.016513921,
-0.010668518,
0.0054685986,
-0.011893956,
0.0138140265,
0.027339716,
0.0027752563,
0.0149280615,
0.02128461,
-0.011271407,
-0.020432701,
-0.0021854735,
-0.009803503,
-0.029148383,
0.01899101,
-0.006100977,
-0.011140345,
0.0037844405,
0.004318522,
-0.018139102,
-0.009836269,
0.005806085,
-0.012254379,
-0.006068211,
0.009062998,
0.0096921,
0.0061402954,
-0.010032863,
-0.0076802843,
-0.027365929,
-0.028571706,
-0.012981778,
0.0044266484,
0.0012762247,
-0.0017382214,
0.00967244,
0.008243855,
0.031612366,
0.0058814464,
-0.009069551,
0.006887354,
0.015059124,
0.1928197,
-0.014796998,
-0.012916246,
0.0013614156,
-0.0053440887,
-0.014272747,
0.011454895,
0.008145558,
0.00023734667,
0.007208458,
0.021717118,
0.026264999,
-0.0095938025,
-0.004331628,
0.010393286,
-0.024194207,
-0.01634354,
0.016644984,
-0.039554775,
-0.014089259,
0.011146897,
-0.004285756,
0.020458914,
0.002413195,
0.026920315,
0.008021048,
-0.016356647,
-0.0045183925,
0.0435653,
-0.019764282,
-0.020629296,
0.023787912,
0.0024525141,
-0.0068480354,
-0.0057897023,
0.016776048,
-0.0042955857,
-0.005403067,
-0.0041514165,
-0.007883432,
-0.002291962,
0.015976565,
-0.009351336,
0.020563764,
0.0051311115,
-0.0019299008,
-0.019357987,
-0.009344783,
-0.0023869826,
0.0041153743,
-0.04479729,
-0.00735918,
0.013827133,
0.023918975,
-0.012110209,
0.0026114278,
0.01807357,
0.0043742233,
-0.008034154,
0.01315216,
-0.016107628,
-0.007516456,
-0.0024705352,
0.023735486,
-0.03258223,
0.016815366,
-0.021035591,
0.022516603,
0.0044856267,
-0.012175741,
-0.012437867,
-0.022070987,
-0.006015786,
-0.007398499,
-0.0024803649,
-0.023027746,
0.028335793,
0.015648907,
0.008099685,
0.02982991,
0.011605618,
-0.022516603,
-0.03677624,
0.019607006,
-0.0078047942,
-0.03347346,
0.015360569,
0.015858607,
-0.025177179,
-0.007968623,
0.022818046,
-0.013879558,
-0.0044037127,
0.0055701723,
0.02809988,
0.005737277,
-0.0068808007,
0.00019106509,
-0.0075492216,
-0.0007671274,
-0.048126288,
0.0604462,
0.0057733194,
0.0062484224,
-0.008230749,
0.0018692842,
-0.010419498,
0.0030455736,
0.007758922,
0.0031209346,
0.002326366,
-0.0220972,
0.0044725207,
-0.01941041,
-0.01511155,
0.026592657,
-0.015911033,
-0.030773563,
0.032031767,
-0.028388219,
-0.010314648,
-0.016068308,
0.015150868,
0.016291115,
-0.019213818,
0.012686886,
-0.027208652,
-0.0027687033,
0.010052523,
-0.026998952,
0.008014495,
0.017431362,
-0.00018871007,
0.006540037,
0.0064548464,
-0.00088549353,
0.021310823,
-0.005806085,
0.0028637238,
0.019973982,
-0.017326511,
-0.005786426,
0.019135179,
0.02432527,
-0.014954274,
-0.00679561,
0.019856025,
0.005943701,
-0.022569027,
-0.035491828,
-0.026946526,
-0.019397305,
0.003971205,
-0.010170479,
0.030825987,
0.002491833,
0.0076409657,
-0.02993476,
-0.015753757,
0.010688177,
-0.021297717,
0.020078832,
0.018230846,
-0.024207313,
-0.003225785,
-0.011638383,
-0.16335677,
0.011310726,
0.028440643,
-0.017785233,
0.023604423,
-0.005494811,
-0.0074509243,
-0.0052392385,
-0.0071822456,
0.00070159597,
0.039266437,
0.007536115,
-0.015412994,
0.008800872,
0.031166751,
0.03349967,
-0.0045937537,
0.021009378,
0.011094472,
0.026789252,
0.0064024213,
-0.034967575,
0.006205827,
-0.004600307,
-0.0013630539,
0.0006102615,
0.009954225,
-0.020537551,
-0.028178519,
-0.014076153,
-0.0040138005,
0.001340937,
0.028964896,
-0.0019118796,
0.05640946,
0.009731418,
-0.011926722,
0.019659432,
0.0009534824,
0.0051180054,
0.030773563,
0.012988331,
0.0018987734,
0.02117976,
-0.014207216,
0.030196887,
-0.006114083,
-0.0083421515,
0.038925674,
-0.012391995,
0.020943847,
0.00048329434,
-0.005052474,
0.0061435723,
0.0048165605,
0.026343638,
0.010177032,
0.0066711004,
0.0028112987,
-0.015059124,
-0.010773368,
-0.0028112987,
0.028388219,
0.014115471,
-0.007241224,
-0.050249506,
0.0036435479,
0.008388024,
-0.011841531,
0.0000934335,
-0.026382957,
-0.0087222345,
0.006359826,
-0.013997515,
0.03279193,
0.019921556,
-0.017392043,
0.0059699137,
-0.002378791,
0.016789153,
-0.019567687,
0.0020724316,
-0.01786387,
-0.016684303,
-0.004547882,
-0.008571512,
0.019187605,
0.0000042301053,
-0.028860046,
-0.008755,
0.04469244,
-0.030196887,
0.011382811,
-0.015334357,
0.02962021,
0.026946526,
0.008755,
-0.005111452,
0.0039023971,
-0.025399985,
0.02499369,
-0.02036717,
-0.011684255,
0.011500767,
0.008374917,
0.016710516,
-0.007994835,
-0.0076802843,
0.0619141,
-0.020799678,
-0.030590074,
-0.0010902793,
0.015897926,
0.019580793,
0.006100977,
0.02943672,
0.016605666,
-0.00817177,
-0.012005359,
-0.040577065,
0.06311988,
0.013538795,
0.002342749,
0.0352297,
-0.00026376403,
-0.0302231,
-0.1394509,
-0.01842744,
0.00965278,
0.006572803,
-0.019069647,
0.009849375,
-0.006123913,
0.002332919,
-0.031481303,
0.02820473,
-0.033866648,
-0.016225584,
-0.006674377,
-0.014181003,
0.022464177,
-0.013093181,
0.009331676,
-0.008755,
-0.03612093,
0.04104889,
0.0043119686,
-0.007011864,
0.005930595,
-0.015098443,
0.017916296,
0.01475768,
-0.027837755,
0.008689469,
0.006051828,
0.008886063,
0.008125898,
0.0009149827,
0.023342298,
-0.017169237,
-0.020904528,
-0.0008666533,
0.016225584,
-0.023040853,
0.0152295055,
-0.013971303,
-0.0025835768,
0.010871666,
0.0067562913,
0.01325701,
0.0028407879,
-0.0034600599,
-0.04235952,
0.00873534,
0.01475768,
-0.021835076,
-0.032922994,
-0.025334453,
-0.025557261,
-0.008945041,
0.013774708,
-0.025662111,
0.010583327,
0.024141781,
-0.008899169,
-0.013918878,
-0.009115423,
-0.0058486806,
0.0066874833,
0.011762893,
0.014888742,
-0.02870277,
0.0046887742,
-0.012385442,
0.0084797675,
-0.0127524175,
0.006749738,
-0.0141941095,
-0.023132598,
-0.022857364,
-0.03137645,
-0.0034535066,
-0.009685546,
-0.016972642,
0.0059371484,
-0.017575532,
-0.02040649,
-0.03462681,
0.012850715,
-0.030170674,
0.02580628,
0.012025018,
-0.0026704061,
-0.017313406,
0.0016407433,
-0.0049771126,
0.0003057451,
0.0402363,
0.0067693973,
-0.007201905,
-0.0036435479,
-0.009973885,
0.0014539787,
0.011376257,
0.009017126,
0.012582036,
-0.025504835,
-0.01849297,
-0.0481525,
0.0053244294,
-0.003872908,
0.002572109,
0.015963458,
-0.0156095885,
0.0021199419,
-0.016618771,
-0.0013450327,
0.03551804,
0.0000081530325,
0.018335696,
-0.0010878219,
0.00967244,
-0.02311949,
0.0048886454,
0.0310619,
0.0073722866,
0.011559745,
0.034443323,
-0.0029423614,
0.0141678965,
-0.015046018,
0.0068283756,
-0.008584619,
-0.0019954322,
-0.015046018,
0.036802456,
-0.018925479,
-0.0043578404,
0.0037320154,
-0.01817842,
-0.011212429,
-0.0020331128,
-0.0015186911,
-0.016998855,
-0.01094375,
0.03308027,
0.005157324,
0.050039805,
0.00015911851,
-0.027156228,
0.018624034,
-0.0027064483,
0.018060464,
0.0065498673,
-0.031900704,
0.0058290213,
-0.0026163426,
-0.012686886,
0.038637336,
-0.0009190784,
-0.011762893,
-0.01747068,
-0.019764282,
-0.0072150114,
0.012850715,
-0.01849297,
-0.018597823,
-0.018715778,
0.015544057,
0.025033008,
-0.0057798726,
0.024613608,
0.00806692,
0.0016432008,
-0.025950449,
-0.0052916636,
0.018637141,
-0.025793174,
-0.029593997,
-0.0108389,
0.00041981076,
-0.01694643,
0.009449633,
0.01994777,
-0.013892665,
0.018322589,
0.007844113,
0.02619947,
0.016186265,
0.0018463483,
-0.009554484,
0.0049509,
0.025950449,
-0.016776048,
-0.021769544,
0.008086579,
0.0036173353,
-0.006697313,
-0.008086579,
0.01429896,
0.0067366315,
-0.0067235255,
0.006625228,
0.0016472965,
-0.00087484467,
0.011664595,
0.001879114,
0.036881093,
0.009993544,
-0.010661965,
0.0018283271,
-0.006507272,
-0.021022486,
0.020681722,
-0.022503495,
-0.015688226,
-0.021153549,
0.018532291,
0.006245146,
0.016710516,
-0.002567194,
-0.012857268,
-0.02549173,
0.028781407,
-0.0053997906,
-0.011356598,
-0.0006917662,
0.037064582,
0.025989767,
0.00967244,
0.008302833,
0.0044200956,
0.0011468001,
0.02799503,
0.02051134,
-0.010085288,
0.034888938,
-0.011441789,
0.046946723,
0.0073133083,
-0.015373675,
-0.010511243,
-0.011697361,
-0.008866403,
0.0011009282,
0.0041350336,
-0.026002875,
0.07224186,
0.016959535,
-0.02545241,
0.016789153,
-0.028335793,
0.0306425,
0.013119394,
0.011913615,
-0.0067759505,
-0.028860046,
0.00094692927,
-0.013099735,
0.0001865598,
-0.04073434,
-0.0045052865,
0.02463982,
-0.01588482,
0.0431459,
0.004144863,
-0.024613608,
0.011107579,
0.0011640021,
0.009823162,
0.023709273,
-0.030930838,
-0.005494811,
0.034967575,
0.008918828,
-0.01254927,
-0.025727643,
-0.012280591,
0.004790348,
-0.032293893,
0.011441789,
0.029148383,
-0.013368413,
-0.009298911,
-0.029698847,
0.024810202,
0.026671294,
-0.0045577115,
-0.003512485,
-0.01325701,
-0.034862723,
-0.009777291,
-0.027706692,
-0.003915503,
-0.024587395,
-0.01394509
] |
Type 2 diabetes mellitus (T2DM) affects more than 7% of adults in the US and leads to substantial personal and economic burden. In prediabetic states insulin secretion and action—potential targets of preventive interventions—are impaired. In trials lifestyle modification (i.e. weight loss and exercise) has proven effective in preventing incident T2DM in high-risk groups, although weight loss has the greatest effect. Various medications (e.g. metformin, thiazolidinediones and acarbose) can also prevent or delay T2DM. Whether diabetes-prevention strategies also ultimately prevent the development of diabetic vascular complications is | [
-0.02017454,
-0.04061177,
0.03217944,
-0.024482645,
0.011919528,
0.025599075,
-0.017363764,
-0.0026449533,
-0.021015147,
-0.010310556,
0.00081638916,
0.027608648,
-0.0035824256,
0.01151236,
-0.016076587,
0.00013113944,
0.049280517,
-0.011814453,
0.022197248,
-0.011374448,
-0.0320481,
0.01151236,
0.0013306857,
-0.003109585,
-0.027661186,
0.0071845534,
0.013049092,
-0.032888703,
-0.017508244,
-0.01552494,
0.009489652,
-0.0064884266,
-0.0049910974,
-0.010796531,
0.010415632,
-0.0072764945,
0.00007162389,
0.013869997,
0.005073188,
-0.0351741,
0.016969731,
0.000011883871,
-0.0091678575,
-0.008340387,
-0.003769592,
0.025310118,
0.028028952,
0.0152228465,
-0.023484426,
0.015367326,
0.004669303,
0.028580599,
-0.020713054,
-0.0029371951,
-0.004744826,
0.003057047,
-0.0065573826,
0.019714834,
0.017048538,
-0.041820142,
-0.006186334,
0.0008988901,
-0.03522664,
-0.007486646,
-0.004633183,
0.0058743902,
-0.0051815473,
0.014776275,
0.022262922,
0.010625783,
0.025165638,
0.0421091,
0.0012371026,
-0.016917193,
0.023839056,
-0.027582379,
-0.012490878,
-0.010553543,
0.006012302,
0.00621917,
0.02411488,
-0.022748897,
-0.017298093,
0.023536963,
0.008051428,
0.0053982656,
0.0016130767,
-0.0009038155,
-0.016601965,
-0.004659452,
-0.014355972,
0.0070794774,
0.008261579,
0.037012927,
0.0033854088,
0.004488704,
-0.011886693,
0.01858527,
-0.0020062898,
-0.0043278066,
-0.006692011,
0.011781616,
-0.014933889,
-0.016733311,
-0.0220265,
0.0041307895,
-0.013843727,
0.014067014,
0.014802543,
-0.009286067,
-0.016129125,
0.058264494,
-0.0119852,
-0.032231983,
-0.0033722743,
0.0077296337,
0.0069678347,
0.0005951555,
0.0006177304,
-0.0052767717,
0.018164968,
0.019662296,
0.02176381,
-0.009259799,
-0.01476314,
0.00040162736,
0.0023970401,
0.0016368829,
-0.017876009,
-0.0001977353,
0.015958376,
0.008990542,
0.008511134,
-0.009325472,
-0.03349289,
0.013252676,
-0.021002011,
0.00006326093,
-0.030629575,
-0.029841509,
-0.009575026,
0.019675432,
-0.01108549,
-0.011098624,
-0.0036218292,
0.029158516,
0.026163857,
0.013541635,
0.00009271086,
-0.0069284313,
-0.007769037,
-0.024719067,
0.013581038,
-0.009154723,
0.01844079,
0.006721563,
0.012359533,
0.031154955,
-0.0320481,
-0.012779836,
-0.00023970401,
-0.023839056,
-0.0006883281,
0.01402761,
0.0044591515,
0.0043212394,
-0.0056248354,
-0.0077887387,
-0.014500451,
0.006117378,
-0.0104353335,
0.039718628,
-0.019031841,
0.026439682,
-0.022249786,
0.012510579,
-0.0028157013,
-0.0033689907,
-0.0111380275,
-0.010054434,
-0.022578148,
0.028344179,
0.0036185456,
0.018559001,
-0.035857093,
0.017324362,
0.018532733,
-0.0010343392,
0.012372668,
-0.04463092,
0.011624003,
0.023602637,
-0.0077821715,
-0.017271824,
-0.63717926,
-0.026781177,
0.009772043,
0.0019603192,
-0.005680657,
0.017429437,
0.016733311,
0.021107087,
-0.018532733,
0.0051519945,
0.017797202,
0.012116546,
-0.010789964,
-0.01844079,
0.0049122907,
-0.015183443,
-0.008209041,
-0.034596186,
-0.0044328826,
-0.02731969,
-0.013384022,
0.0362774,
-0.017403169,
0.0077493354,
0.017915413,
0.0012822523,
-0.0032606313,
-0.0074209734,
-0.0046298993,
0.03525291,
-0.009627564,
0.03449111,
0.0037334722,
0.011676541,
0.047126465,
0.0032015261,
-0.009220395,
0.0053719967,
0.0043015378,
0.033361547,
-0.027923876,
0.014933889,
0.020910071,
0.01908438,
0.008057996,
0.009929657,
0.016273605,
0.01279297,
0.019767372,
0.016601965,
0.022459937,
0.005266921,
-0.028160296,
-0.017455706,
0.044683456,
-0.00051429647,
0.021921424,
-0.012431772,
0.015538074,
0.0038943694,
-0.005670806,
0.024180554,
-0.0032425714,
0.0041340734,
-0.02710954,
0.010881905,
0.00038972424,
0.02458772,
-0.0068036537,
-0.004015863,
-0.0061699157,
0.026203262,
0.0021474853,
-0.003743323,
0.047494233,
0.017455706,
0.016838387,
0.025796093,
-0.02131724,
-0.008708151,
0.007256793,
0.003375558,
0.003391976,
0.001558897,
0.02808149,
0.021212164,
0.010415632,
-0.0059663313,
-0.0073290323,
-0.0012797896,
0.025914302,
-0.0015515089,
-0.024206823,
-0.03372931,
-0.012799538,
0.018073026,
0.0010425483,
0.021474853,
0.03598844,
0.018414522,
-0.034228418,
0.0060681235,
0.01193923,
-0.003562724,
0.0145661235,
0.011886693,
-0.036093514,
0.0126878945,
0.043448817,
-0.033886924,
0.018296313,
-0.022249786,
-0.02687312,
-0.007979188,
0.037512038,
-0.024272494,
-0.00026063708,
-0.01799422,
0.004469002,
-0.03543679,
-0.014723737,
0.012352966,
-0.0071648513,
-0.0025431612,
0.00059720775,
0.007512915,
0.005362146,
-0.0011180715,
0.0099887615,
-0.029000903,
0.004905723,
0.027582379,
0.025979975,
0.0050173663,
0.018309446,
-0.016076587,
0.007801873,
0.0046200487,
-0.012563117,
-0.011873558,
0.004597063,
-0.020568574,
0.00046545267,
-0.01587957,
0.018677212,
-0.014067014,
0.0005171696,
0.0029700312,
-0.0006259394,
-0.021093953,
0.00985085,
-0.026032513,
-0.007815008,
0.012891479,
0.00042276565,
-0.01882169,
0.018270044,
-0.035410523,
-0.0071123135,
0.00575618,
0.008281281,
0.011761915,
0.00083403866,
-0.015708823,
-0.012819239,
-0.029683894,
-0.0004281015,
0.0123661,
-0.021579929,
-0.022118442,
-0.00030209273,
-0.025769824,
0.008859198,
0.023917863,
-0.016063452,
0.038300104,
-0.0058776736,
-0.004567511,
-0.02055544,
0.012471176,
-0.0022328594,
-0.004180044,
-0.029920315,
0.023812788,
0.036329936,
-0.0033821252,
0.015380461,
-0.007512915,
-0.0046463176,
0.032231983,
-0.026518488,
0.016431218,
0.003487201,
0.0058973753,
0.0003127645,
-0.013489097,
0.0045510926,
-0.0050600534,
-0.023930999,
0.011958932,
0.052065026,
-0.005191398,
0.002979882,
-0.03425469,
0.009883686,
-0.037091732,
0.004754677,
-0.018782288,
0.028659405,
0.01872975,
-0.00287809,
0.0061797667,
-0.01476314,
-0.01996439,
-0.0005261996,
0.024889814,
0.00868845,
-0.015708823,
-0.013239542,
-0.005979466,
-0.0075260494,
-0.031943023,
0.0177578,
-0.025914302,
-0.013449694,
0.034517378,
0.022709493,
-0.0023953984,
-0.034044538,
-0.027503572,
-0.021343509,
-0.011650272,
0.00823531,
0.013475963,
0.0050239335,
0.014303434,
0.0053161755,
-0.010566678,
0.02670237,
0.032310788,
0.024469512,
-0.0032557058,
0.01884796,
0.0050896057,
0.00016182073,
0.0007975084,
0.036356203,
0.023550099,
-0.0028288357,
0.024246225,
0.0008939646,
0.0019455429,
0.0029240607,
-0.030918535,
-0.003963325,
-0.0046134815,
0.017889144,
0.0013265811,
0.043711506,
0.03640874,
0.01514404,
0.013200139,
-0.017560782,
0.0022574863,
0.005930212,
-0.010244884,
0.02314293,
0.0028649555,
0.011794751,
0.0026613714,
-0.04132103,
-0.004393479,
0.0043803444,
-0.02366831,
0.0130884955,
0.014579258,
-0.0069941035,
-0.014841947,
0.03496395,
0.013804324,
-0.005250503,
-0.025638478,
0.019307666,
0.0044230316,
-0.00837979,
-0.01440851,
-0.004377061,
-0.019544085,
0.022538744,
0.017035402,
0.002981524,
0.018256908,
0.00034149614,
0.0020161406,
0.0016196439,
0.000116671006,
0.029894046,
0.0031374956,
0.02034529,
-0.00008994031,
0.012543416,
0.015984645,
-0.020804996,
-0.018151833,
0.034911413,
0.004196462,
0.01132191,
0.010796531,
-0.016969731,
-0.0052899066,
-0.010829368,
-0.0025907736,
0.010901608,
-0.005201249,
0.015157174,
0.026636697,
-0.011755347,
-0.0072173895,
0.007920084,
-0.011387583,
-0.0018700197,
-0.027162077,
-0.0024348018,
0.006688727,
0.03646128,
0.0130162565,
0.011709377,
0.0032179444,
-0.008970841,
0.027477304,
-0.0074209734,
-0.024745336,
0.025559671,
0.011617436,
0.013975073,
0.0029437623,
0.01101325,
-0.013869997,
0.025835495,
0.003185108,
-0.0139094,
-0.03714427,
0.011459822,
-0.008294416,
0.0062914095,
-0.010737427,
0.0502262,
0.026689237,
0.04649601,
-0.032310788,
0.0005775061,
0.023353081,
-0.0017107642,
0.0038779513,
-0.005096173,
0.015682554,
-0.007867546,
0.04602317,
-0.01115773,
-0.017902277,
-0.00022800613,
0.013896266,
0.01735063,
-0.0036710834,
0.019360203,
0.030393155,
0.015840167,
0.015485536,
-0.018624673,
-0.023773385,
-0.01799422,
0.024916083,
0.009161291,
-0.019399608,
0.007480079,
0.009456816,
-0.025927437,
-0.030892266,
0.007900381,
0.010409065,
0.007637692,
-0.024955487,
-0.0111380275,
-0.014592392,
-0.007801873,
-0.026071915,
0.009758908,
-0.016877789,
0.0033821252,
0.012195352,
0.0047349753,
-0.0026958492,
0.000028988177,
0.0027024164,
0.030577037,
-0.0046430337,
0.004909007,
0.0066493237,
-0.00857024,
0.0015941958,
0.012490878,
-0.017284958,
0.0088789,
0.017403169,
-0.015866436,
0.0017288241,
0.011952365,
-0.02672864,
0.024482645,
-0.004882738,
-0.026360875,
-0.025428327,
-0.016207932,
0.0030816742,
-0.022079038,
-0.025756689,
0.031837948,
-0.03814249,
-0.011111759,
-0.032021828,
0.012641924,
0.020962609,
-0.004666019,
-0.019228859,
-0.003579142,
-0.0050666207,
-0.0041373568,
-0.036329936,
-0.005355579,
-0.01255655,
0.0073355995,
-0.00032528327,
0.009299202,
-0.026662966,
0.0064161867,
0.008832929,
0.012306995,
0.002108082,
0.017179882,
0.018545866,
-0.017179882,
-0.005355579,
-0.00024462945,
-0.0008438895,
-0.017928546,
-0.0009087409,
0.012714163,
-0.020752458,
-0.032599747,
0.014040745,
0.029473742,
-0.022683224,
-0.044946145,
0.013751786,
0.011387583,
0.03590963,
0.005112591,
-0.029946584,
-0.04602317,
-0.0065475316,
0.010179211,
-0.006941566,
-0.018217506,
-0.002731969,
-0.0019980806,
0.00065918604,
-0.006439172,
-0.020135136,
0.05245906,
-0.033808116,
0.0055722976,
-0.0068627587,
-0.0090956185,
0.028633136,
0.018178102,
0.0016779281,
-0.050410084,
-0.0026548041,
-0.013830593,
-0.02290651,
-0.0024545034,
-0.010218615,
0.017166749,
0.033177663,
0.0023527113,
0.018020488,
-0.00804486,
-0.0030685398,
0.0132986475,
0.03049823,
-0.0042621344,
0.011518927,
-0.027372228,
0.021461718,
-0.00830755,
-0.000089016794,
0.021448584,
0.012149381,
0.03472753,
-0.02069992,
-0.009332038,
-0.022538744,
-0.021474853,
-0.028449254,
-0.009903388,
0.0027516708,
-0.00093008444,
0.005424535,
-0.034386035,
-0.032100637,
0.0070794774,
0.023221737,
0.019767372,
0.018703481,
0.0074209734,
-0.014881351,
0.027739994,
0.008215609,
0.00040819458,
-0.015301653,
-0.0028157013,
-0.011840722,
-0.01981991,
0.03002539,
-0.0011689676,
-0.019833045,
-0.012024604,
-0.0069875363,
-0.012201919,
0.018046757,
-0.045471523,
-0.0020949475,
-0.0025382356,
-0.018033622,
-0.003881235,
-0.0058382703,
-0.030971073,
-0.026899388,
0.00072608975,
0.017179882,
-0.02452205,
0.016588831,
-0.0144479135,
-0.0055722976,
-0.023090392,
-0.019005572,
0.0024873395,
0.0023839057,
0.01723242,
0.015104637,
0.0073618684,
-0.000770829,
0.010750561,
0.0035233207,
0.003828697,
0.021724408,
-0.009272933,
0.015905838,
-0.017298093,
0.011151162,
0.005053486,
-0.01796795,
-0.046101976,
0.005191398,
0.0072699273,
-0.0042325817,
-0.0055460287,
-0.019609759,
-0.018650943,
0.009942791,
-0.0049648285,
0.008465163,
0.004652885,
-0.012405504,
-0.009240097,
0.02608505,
-0.013804324,
0.0039501907,
-0.014290299,
-0.028028952,
0.0048104986,
-0.026899388,
0.021619331,
0.0009522488,
0.00042851196,
0.009962493,
0.000638253,
0.00804486,
0.008727853,
0.0007921725,
0.010625783,
0.012773269,
-0.008793525,
0.03273109,
0.01502583,
-0.010389363,
0.01476314,
-0.0061206613,
-0.011860424,
0.01647062,
-0.011958932,
-0.014920754,
-0.032442134,
-0.01015951,
0.02366831,
0.016102856,
-0.028764483,
0.016129125,
-0.02710954,
-0.020161407,
-0.016812118,
-0.0093780095,
0.008800092,
-0.0068561914,
-0.009450248,
-0.024653394,
-0.012477743,
0.022735761,
-0.0014464331,
0.00799889,
0.009561892,
0.009955926,
-0.0055394615,
0.016601965,
0.004271985,
0.012838941,
0.005463938,
0.0037531739,
-0.040454157,
-0.03328274,
0.019596623,
0.008675315,
-0.03590963,
-0.0130162565,
0.011919528,
-0.010763695,
-0.012458041,
-0.014106417,
0.013351185,
0.011807885,
0.019071246,
-0.0022377847,
-0.0227883,
0.02884329,
-0.03252094,
0.012254457,
0.007539184,
0.0071057463,
-0.010501006,
0.0089314375,
-0.005046919,
-0.008123668,
0.003314811,
-0.015748225,
-0.036986656,
0.03598844,
-0.0033443635,
0.0155512085,
0.00880666,
0.009509354,
-0.018046757,
0.0048663197,
-0.001585166,
0.008156504,
-0.032862436,
-0.00021918141,
-0.016037183,
0.021015147,
-0.020529171,
-0.017836606,
-0.026426546,
-0.014552989,
-0.025047427,
-0.012116546,
-0.02228919,
0.030918535,
0.0148944855,
0.00093911437,
-0.0064457394,
-0.0016327783,
-0.035069026,
-0.004692288,
-0.00020450774,
0.017600184,
0.0070794774,
0.01996439,
0.0020653948,
0.02955255,
0.0040552667,
0.017153613,
-0.031470183,
-0.02734596,
-0.0063537983,
0.0025710717,
0.026360875,
-0.002219725,
-0.014947023,
-0.019360203,
0.02487668,
-0.03175914,
0.007315898,
-0.00394034,
-0.0027943577,
0.0062323045,
0.0017288241,
0.008990542,
0.025441462,
-0.0076770955,
0.007933218,
-0.027871339,
-0.0020227078,
0.0035725748,
-0.014106417,
-0.0141195515,
-0.030708382,
-0.0062651406,
-0.0026433114,
0.0046890047,
-0.016063452,
-0.01723242,
-0.0075326166,
-0.032836165,
-0.0066591743,
0.0018355417,
0.028449254,
-0.016483756,
0.008819794,
0.018217506,
-0.015393595,
0.014815678,
0.010494439,
-0.0033558563,
0.0069284313,
0.014789409,
-0.00923353,
-0.01039593,
0.00048761707,
-0.02264382,
0.015932107,
0.0067051454,
-0.013009689,
-0.01608972,
0.014710602,
-0.0015400162,
-0.021356642,
0.0019504683,
0.011440121,
-0.00363168,
0.015459267,
-0.02366831,
0.029184785,
-0.0026219678,
-0.020778727,
0.002800925,
-0.003966609,
0.014947023,
-0.0129702855,
-0.016102856,
-0.025402058,
0.01905811,
0.19691192,
-0.008524269,
0.008346953,
0.025559671,
0.019215725,
0.033098854,
0.03984997,
0.010881905,
-0.013219841,
-0.020043196,
-0.0111380275,
-0.007795306,
-0.02852806,
-0.0010220257,
0.009483085,
-0.013095063,
-0.019228859,
-0.0012945659,
0.025743555,
-0.010008464,
-0.016812118,
-0.0133446185,
0.013219841,
-0.008465163,
0.024075476,
0.020397827,
0.016194798,
0.033624236,
0.03225825,
0.013101631,
-0.0058481214,
0.0037892936,
0.00857024,
0.021212164,
0.0005319459,
0.0017353914,
-0.0008676957,
-0.024863545,
0.012004903,
0.00055944617,
0.0068561914,
0.0012231471,
-0.04160999,
-0.021435449,
0.0027122675,
0.0066493237,
-0.018361984,
-0.024824142,
-0.0022295758,
-0.012261025,
-0.020476634,
-0.00906935,
0.035778288,
0.00075317954,
0.005250503,
-0.004409897,
0.018650943,
0.006948133,
-0.010573246,
0.014040745,
-0.0015424789,
-0.0019570356,
-0.011807885,
0.02808149,
-0.03049823,
0.03149645,
-0.024850411,
-0.001370089,
0.011315343,
-0.014592392,
-0.0009941149,
-0.010730859,
-0.0060057347,
0.0018027056,
0.0035660076,
-0.011742213,
0.02414115,
0.0057496126,
0.007841277,
-0.000001176843,
-0.014382241,
-0.0014185224,
-0.0044493005,
-0.02399667,
-0.0054081166,
-0.036723968,
0.014382241,
-0.022394266,
-0.009535623,
-0.00018726876,
-0.00077657535,
-0.003470783,
-0.026859984,
0.004340941,
0.030918535,
-0.0158533,
-0.023720847,
0.0031374956,
0.012944017,
-0.044315692,
-0.027451035,
0.09026005,
-0.016680773,
0.007033507,
-0.00076754537,
-0.002776298,
-0.019333934,
-0.004771095,
0.011998335,
0.007847844,
0.0044328826,
-0.025296982,
0.009942791,
-0.02179008,
-0.010172645,
0.013883132,
0.024745336,
-0.021435449,
-0.011669974,
-0.015117771,
0.020489767,
-0.010612649,
0.0022574863,
0.015038964,
-0.0061534974,
0.008905169,
-0.0078084404,
-0.007703365,
-0.014421645,
-0.011926096,
0.0025940572,
-0.020292751,
-0.0027943577,
-0.0007552318,
-0.0052800556,
-0.0086490465,
0.0098705515,
0.0033295872,
0.008281281,
0.020450365,
-0.019018708,
-0.020108867,
-0.012976853,
-0.0049910974,
0.028580599,
-0.018532733,
0.02238113,
-0.005578865,
0.002328084,
-0.016155394,
-0.021973962,
0.0008668748,
0.005230801,
-0.00548364,
0.044604648,
-0.002158978,
0.0073355995,
-0.026676102,
-0.014158955,
0.010612649,
-0.026820581,
0.027634917,
0.01905811,
-0.02131724,
0.005805434,
0.017626455,
-0.16412829,
0.034307227,
0.017521378,
-0.022420535,
0.02611132,
-0.0123661,
-0.001336432,
-0.017363764,
0.0010400856,
0.024311898,
0.023510695,
-0.01934707,
-0.022052769,
0.013443126,
-0.00071418664,
0.0013175511,
-0.017258689,
0.03911444,
0.018191237,
0.0065672332,
0.009404278,
-0.008484866,
-0.0014185224,
-0.022683224,
-0.004196462,
0.008622778,
0.0068824603,
0.035620674,
-0.009075916,
-0.01355477,
-0.016010914,
0.015682554,
0.037774727,
0.0024134582,
0.0052636373,
-0.016155394,
-0.00012744537,
-0.014185224,
-0.0034379466,
0.01908438,
0.03514783,
0.016076587,
-0.0019422593,
-0.013817458,
-0.016825251,
0.012536848,
0.0039961613,
-0.00402243,
0.0054705054,
0.011335045,
0.031233761,
0.011551763,
0.017534513,
-0.00043220603,
0.0034609318,
-0.00097359234,
-0.019294532,
0.00093665166,
0.0031998844,
-0.016444352,
-0.012142815,
-0.024561452,
0.019911852,
0.029788971,
-0.0057331948,
-0.025835495,
0.0018700197,
-0.020910071,
-0.0019406175,
0.011886693,
-0.036618892,
-0.0072436584,
0.014960158,
-0.008484866,
0.03696039,
0.017784068,
-0.00911532,
0.00076959765,
-0.014868217,
-0.006662458,
-0.021396047,
-0.007480079,
-0.016037183,
-0.01796795,
0.0064260378,
0.037196808,
0.01837512,
0.0020046479,
0.014198358,
-0.0031719736,
-0.0002665886,
-0.041452378,
0.017928546,
-0.02214471,
-0.02003006,
0.03102361,
0.0117487805,
0.002868239,
0.016943462,
0.010389363,
0.0000060798216,
-0.0022624119,
-0.021002011,
0.005037068,
0.0026761475,
0.003579142,
-0.0031325703,
-0.0041307895,
0.02928986,
0.016339276,
0.0032409297,
0.008386357,
0.012306995,
-0.0058120014,
0.017862875,
0.028370447,
0.004084819,
-0.00738157,
0.015813898,
-0.011729078,
0.048544988,
0.008077697,
0.004692288,
0.026374009,
0.0040125796,
-0.021987097,
-0.13743906,
-0.044972412,
0.019859314,
-0.0014439704,
0.014250896,
0.025099965,
-0.0020079315,
0.00334108,
-0.030235542,
0.00985085,
-0.029920315,
0.008583374,
-0.0006353798,
-0.011775049,
0.020975742,
-0.008281281,
-0.0035266043,
-0.01996439,
-0.024443243,
0.04063804,
-0.012096844,
-0.028370447,
-0.014618661,
-0.018033622,
-0.002809134,
0.016956596,
-0.009292635,
0.013699248,
0.0017238987,
0.011315343,
0.013646711,
0.008944572,
0.013896266,
0.016102856,
0.0033460055,
0.010231749,
-0.0076179905,
-0.028685674,
0.028422985,
-0.038510256,
-0.007821575,
0.004291687,
0.022065904,
-0.009010244,
0.011118326,
-0.015735092,
-0.019281397,
-0.0061009596,
0.020975742,
-0.018769152,
-0.011052653,
-0.011683108,
-0.04163626,
-0.019911852,
0.011801318,
-0.014080148,
-0.0018027056,
0.018243775,
0.0028731646,
0.008202475,
0.024206823,
0.021080818,
-0.015866436,
0.026452815,
0.038746677,
-0.01298342,
0.010606082,
-0.027687455,
-0.0038615332,
-0.029657625,
-0.006688727,
0.006902162,
-0.007900381,
0.008169638,
-0.022394266,
0.019491548,
-0.0040651173,
-0.01714048,
0.0130162565,
-0.021277836,
-0.012451475,
-0.020673651,
0.028922096,
-0.010592948,
0.0173769,
0.006202752,
0.027240884,
0.0000079653355,
0.008819794,
-0.005414684,
0.0019915134,
0.04484107,
0.005191398,
0.0063866344,
0.0031719736,
0.041741334,
-0.0007934039,
-0.02884329,
0.01993812,
0.023917863,
0.0038582496,
-0.009575026,
-0.037512038,
0.0040388484,
0.005490207,
0.00510274,
-0.025572807,
-0.009982195,
0.0048302,
-0.00394034,
0.011367881,
0.0009826223,
-0.035305448,
0.018099295,
0.008701584,
-0.0031966008,
-0.032626014,
-0.023169199,
0.008130235,
-0.011354746,
0.018900497,
0.013567904,
-0.006054989,
-0.0008956064,
0.0032277952,
0.01664137,
-0.0057167765,
0.016720176,
-0.009588161,
0.031233761,
-0.01243834,
-0.0064851427,
0.026295202,
-0.010606082,
-0.009102185,
-0.0026433114,
-0.01426403,
-0.005286623,
-0.0053654294,
0.021685004,
0.019570354,
0.027503572,
0.015905838,
-0.01578763,
-0.005697075,
-0.015866436,
-0.017508244,
-0.013311782,
-0.03772219,
-0.000017803359,
0.004150491,
-0.029237323,
0.020279616,
0.0039797435,
-0.0011271014,
-0.034858875,
-0.026597295,
-0.012096844,
0.00830755,
-0.019885583,
-0.046653625,
-0.016930327,
0.016549427,
0.013272379,
-0.016549427,
-0.0056051337,
0.004147208,
-0.033650503,
-0.017245555,
0.006242155,
-0.00007280394,
-0.0075063477,
0.017770933,
0.0041078045,
0.0153410565,
-0.0041242223,
-0.004662736,
-0.0069284313,
-0.014513586,
0.00830755,
0.004088103,
0.040086392,
0.01217565,
-0.013265811,
-0.046863776,
0.021304104,
0.017455706,
-0.0061534974,
0.00086112844,
0.021973962,
-0.0034215285,
-0.014999561,
0.008478298,
0.015774494,
-0.010448468,
0.021593062,
0.029000903,
0.018756019,
0.017324362,
0.0026695803,
0.0019553937,
0.011893259,
0.0076705283,
0.000009171039,
-0.015078368,
-0.020778727,
-0.017665857,
0.0011837438,
0.0037531739,
-0.0312863,
-0.026859984,
0.019530952,
0.011656839,
0.020095734,
0.0052406522,
-0.011558331,
-0.0043376577,
0.020305885,
-0.01367298,
0.014316568,
-0.00977861,
0.014776275,
-0.013147601,
0.020752458,
0.011952365,
-0.008786958,
0.011558331,
-0.0023691293,
-0.008583374,
-0.027398497,
0.0305245,
0.000847994,
0.010881905,
-0.0076770955,
-0.03819503,
-0.02005633,
-0.022105306,
-0.021593062,
0.004882738,
-0.0019241994,
-0.0032737658,
0.065777406,
0.011059221,
-0.009653833,
-0.016221067,
-0.0088854665,
0.014474182,
-0.0011197133,
0.031837948,
-0.02058171,
0.0037301886,
0.010960712,
-0.0016163603,
-0.016943462,
-0.03005166,
-0.03690785,
0.020227078,
-0.0016335993,
-0.008583374,
-0.005920361,
0.010343392,
0.018690346,
0.0023855474,
0.015932107,
-0.0042621344,
-0.027162077,
-0.030603306,
0.026190126,
0.025021158,
-0.0046824375,
-0.042319253,
-0.022748897,
0.0061731995,
-0.015459267,
-0.017429437,
0.01675958,
-0.004915574,
-0.0017091224,
-0.019675432,
0.0039272057,
0.0035857093,
0.009686669,
0.034386035,
-0.03417588,
-0.025835495,
-0.024469512,
-0.028606867,
-0.004882738,
-0.029788971,
-0.030366886
] |
This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5' and 3' boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian | [
-0.042395074,
-0.022770172,
-0.018541235,
-0.035840224,
-0.009918174,
0.015316674,
-0.008319108,
0.015884936,
-0.039619833,
-0.0051507107,
0.004318139,
0.007057035,
-0.0048864023,
-0.01737828,
0.00019472098,
0.009164895,
0.014325517,
-0.011656002,
-0.011741902,
-0.018395867,
-0.03858903,
0.0091252485,
-0.022756957,
-0.003246038,
0.0007384117,
0.015805645,
0.016585354,
-0.027646663,
-0.032087043,
-0.023761328,
0.008431439,
0.0017956453,
-0.02413136,
-0.0028743541,
-0.011180246,
0.0023209583,
0.0046452205,
-0.008074623,
0.028201709,
-0.02669515,
0.0153431045,
0.029100358,
-0.015092012,
0.008695748,
-0.00311058,
-0.014246224,
0.026444059,
-0.0027504596,
-0.0137440385,
0.016717508,
-0.009310264,
0.018765898,
-0.019875994,
-0.007843353,
-0.017893681,
0.0043379623,
0.0049128328,
0.017246125,
-0.017854035,
-0.0025191896,
0.005454665,
-0.003964626,
-0.01988921,
0.004159554,
-0.016373908,
0.0017774742,
-0.015448827,
-0.009112033,
0.013704392,
-0.004678259,
0.030554054,
-0.0007346948,
-0.015395966,
-0.0066572684,
0.039725557,
-0.008808078,
0.009501888,
0.0007004173,
0.008385185,
0.019003777,
0.021712938,
-0.020510335,
0.01601709,
0.007697983,
0.009647258,
0.0099247815,
0.00635001,
0.013611884,
-0.0024861512,
-0.0076847677,
0.021118244,
0.032457076,
0.027858108,
0.016625,
-0.012495181,
-0.024289945,
0.0031138838,
0.026245827,
-0.004380912,
-0.023113772,
-0.018078696,
0.005368765,
0.009078994,
-0.009799235,
-0.009951212,
-0.0075790444,
0.042447932,
-0.013050228,
0.003402971,
-0.013889408,
-0.0045758397,
0.020933228,
-0.02586258,
-0.0005979978,
0.023338435,
-0.011259539,
0.0120722875,
-0.0018220763,
-0.011404909,
-0.0019063245,
0.0389062,
0.03166415,
0.004341266,
-0.021276828,
0.004926048,
0.042870827,
0.0084512625,
-0.0019542305,
-0.012481966,
0.0034393135,
0.005593427,
-0.006627534,
0.026087241,
0.02606081,
-0.03478299,
0.014801272,
-0.017047893,
-0.008015153,
-0.009112033,
-0.041364267,
-0.009131856,
0.034677267,
-0.007195797,
-0.0050515947,
0.021369336,
0.023100557,
0.023602743,
-0.008213384,
0.025215024,
0.013241853,
0.016545707,
-0.0057916585,
0.006825765,
0.019638116,
0.009462242,
0.0014883869,
0.010056936,
0.016294615,
-0.021897953,
-0.010658237,
0.021646861,
-0.004598967,
0.02317985,
0.009977643,
0.020179948,
0.023298789,
-0.0026348247,
-0.014959857,
-0.0025984822,
-0.017827604,
-0.011100954,
0.0001872873,
-0.012534827,
0.005616554,
-0.005183749,
0.0062707174,
-0.00053109473,
0.009838881,
-0.022875894,
-0.017669018,
0.0041727694,
0.00026926422,
0.0017295682,
0.0339372,
-0.033382155,
-0.0031584857,
0.0068125497,
-0.021554353,
0.001485083,
-0.006465645,
-0.0015569419,
-0.0015511601,
0.0074733207,
-0.00033162447,
-0.65421623,
-0.0122969495,
0.012481966,
-0.043373015,
0.010327852,
0.005504223,
0.010030505,
0.00077310216,
-0.012541435,
0.024659976,
-0.009052563,
0.004592359,
0.043505166,
-0.02230763,
-0.041232117,
-0.026074026,
-0.010545907,
-0.018726252,
0.025928658,
0.0009688556,
-0.043743044,
0.009382949,
0.010955584,
0.025677564,
0.002192108,
-0.0064986837,
0.017642587,
-0.01959847,
-0.030686209,
0.00443047,
-0.036553856,
-0.013149344,
-0.025069654,
0.008292677,
0.03790183,
0.013116306,
-0.0042586694,
0.037188195,
0.0028479234,
0.028016694,
0.006574672,
-0.0009903306,
0.031849165,
0.019030208,
-0.024144575,
0.007770668,
0.013380614,
0.022664448,
0.014180147,
-0.021673292,
-0.01128597,
0.0049392637,
-0.007539398,
-0.008940233,
-0.0063235792,
0.01581886,
0.032800674,
-0.007519575,
0.02825457,
-0.015594197,
-0.0004658436,
0.009878527,
-0.0056562005,
-0.015686706,
-0.02040461,
-0.0012728103,
-0.013407045,
-0.0075261826,
0.035813794,
0.001736176,
0.010836646,
0.025294317,
0.008590024,
-0.0023193064,
-0.0024993666,
0.028413156,
0.0059601553,
-0.012138365,
0.016373908,
0.01552812,
-0.0035846832,
0.004701386,
-0.02037818,
-0.005573604,
0.02681409,
-0.004410647,
-0.020682134,
0.019928856,
-0.0026216093,
0.0015164696,
-0.02052355,
-0.013208814,
0.0007433675,
-0.028703896,
-0.037003182,
0.008748609,
0.00575862,
0.024752485,
0.0026612554,
-0.027408784,
-0.0035516445,
-0.01183441,
0.0100238975,
-0.0081274845,
0.022122616,
-0.004090173,
-0.009964428,
0.0134202605,
0.020536765,
0.007863176,
-0.022400139,
-0.011649394,
-0.0021078598,
-0.033435017,
0.005894078,
-0.01852802,
0.02447496,
0.0050615063,
-0.022664448,
-0.00972655,
0.0038655107,
0.01881876,
0.0100238975,
-0.010988623,
0.016373908,
-0.0084843,
0.0061815134,
-0.018660175,
0.013955485,
0.0064557334,
-0.009039348,
-0.0040769577,
0.012977544,
-0.027990263,
0.0137440385,
0.0010423664,
0.03832472,
0.017431142,
-0.009045956,
-0.015607413,
-0.00776406,
0.00075451797,
-0.0042388462,
0.011404909,
-0.0048302365,
-0.032827105,
-0.014510533,
-0.0083125,
0.023853837,
-0.008259638,
-0.0074336748,
-0.012805743,
0.011180246,
0.00040616773,
0.011537063,
0.002353997,
-0.017735096,
-0.031902026,
0.0057156696,
-0.010915938,
0.0019344073,
0.0059568514,
-0.0015495082,
0.010578945,
0.0056760237,
-0.021303259,
-0.0028396638,
0.0128718205,
-0.017153617,
-0.016638216,
0.020576412,
-0.005005341,
-0.014616257,
-0.003402971,
0.008120877,
0.00297347,
-0.0058379127,
0.0039018532,
-0.017272556,
-0.017431142,
-0.013876192,
0.0014057904,
-0.0058742547,
-0.022875894,
0.029338235,
0.011160423,
0.037531797,
-0.0062938444,
0.001576765,
0.0155677665,
0.0057718353,
0.0047212094,
-0.018091911,
0.026748013,
0.0024844992,
0.0017180048,
0.022241555,
0.0018369436,
-0.009012917,
0.012799135,
0.025043223,
-0.008338931,
-0.019783486,
-0.022928756,
0.002989989,
-0.030871226,
0.001074579,
-0.020629274,
-0.0028611387,
-0.025003577,
-0.013929054,
-0.005590123,
-0.008094446,
0.0024432011,
-0.0026562996,
0.021461844,
-0.017893681,
-0.023021264,
0.0001990573,
0.0017196567,
-0.011160423,
0.011755117,
0.0063202754,
0.00790943,
-0.007843353,
0.020391395,
-0.0012587688,
0.01564706,
0.014034778,
-0.0012959372,
0.0014503925,
0.0030544142,
-0.0004707994,
0.0055669965,
0.016122814,
-0.0073940284,
0.015263812,
-0.014642687,
0.026113672,
0.02113146,
-0.0063136676,
0.0022020196,
0.011900487,
-0.022823032,
-0.0038060413,
-0.017285772,
0.018594097,
0.018633744,
0.00014454368,
0.016373908,
0.0027934096,
-0.002945387,
-0.0044668126,
0.008728785,
0.008960056,
-0.0038423839,
0.0049161366,
0.014655902,
0.047707673,
0.02851888,
0.00026905772,
-0.0032988996,
-0.0047179055,
-0.014880565,
0.0083125,
0.000571567,
0.0045130663,
-0.013849761,
0.0111736385,
-0.018779114,
-0.021422198,
0.018911269,
0.012733059,
-0.012951113,
0.013175775,
0.024686407,
0.013374006,
0.02381419,
0.026140103,
0.012204442,
-0.020431042,
-0.024554253,
0.038351152,
0.012825566,
-0.026642289,
-0.010783784,
-0.0001816088,
-0.003657368,
-0.026444059,
-0.0011224849,
-0.0005984108,
0.007486536,
0.015805645,
0.015395966,
-0.016532492,
-0.018898053,
0.036818165,
-0.03325,
-0.005755316,
-0.0036441525,
0.01954561,
0.009118641,
-0.022479432,
-0.0019096284,
0.04271224,
0.006634142,
-0.00038427967,
-0.015514905,
-0.017021462,
-0.008471085,
-0.017285772,
-0.007651729,
0.011008446,
-0.011233108,
-0.018845191,
0.0012728103,
-0.0031221432,
0.0014421329,
0.019994933,
0.02464676,
-0.028994635,
-0.028598173,
0.0072486587,
0.013268284,
0.03010473,
0.029946145,
-0.0001693226,
0.0016758806,
-0.01261412,
-0.003264209,
-0.036210254,
-0.01215158,
0.011887272,
-0.016426768,
-0.029708268,
0.00002204291,
0.016188892,
-0.010380713,
0.027646663,
0.0056066425,
-0.00146113,
-0.04614825,
-0.021858307,
0.005999801,
0.0076120826,
0.01090933,
0.021673292,
0.028598173,
0.014418025,
0.0032030877,
-0.0030527625,
0.025452903,
0.0015660274,
-0.009508496,
0.003971234,
0.013413653,
0.0013925751,
0.019320946,
0.0036507603,
0.002012048,
0.032747816,
-0.006141867,
0.013261676,
0.0063764406,
0.014299086,
0.01711397,
0.019387024,
0.0065647606,
-0.0006793553,
-0.0065416335,
-0.011464378,
0.013367399,
0.001528859,
-0.020351749,
0.021488275,
-0.02540004,
-0.019043423,
-0.019056639,
0.006052663,
-0.0057487083,
-0.011874056,
-0.016096383,
-0.014721979,
-0.027937401,
0.00039006144,
-0.028994635,
-0.016413553,
0.00025191897,
-0.0053059915,
-0.020351749,
0.010631806,
0.009230972,
-0.020946443,
-0.0033203748,
0.0027042057,
-0.023074126,
-0.018924484,
-0.0037597874,
0.021342905,
0.032404214,
0.013407045,
-0.029523252,
0.013836546,
0.026800875,
-0.010843254,
-0.0067596883,
0.013638315,
-0.016188892,
0.0029949448,
0.01145777,
0.00011171161,
-0.008378577,
-0.0016378863,
-0.0072750896,
-0.0065878876,
-0.020457473,
0.01221105,
-0.00043445698,
-0.0028165367,
0.008933625,
0.0030924086,
0.038800478,
0.005943636,
-0.021303259,
0.01394227,
-0.030501192,
-0.022730526,
-0.023312004,
0.0009779412,
-0.010605375,
-0.0035846832,
-0.0016395382,
-0.005454665,
-0.014986288,
0.014497317,
-0.023655605,
0.021831876,
0.027382353,
0.04043919,
0.008167131,
-0.0030494586,
0.022994833,
-0.013955485,
-0.005180445,
0.0008813034,
-0.009363126,
0.009891743,
0.001803905,
-0.019439885,
0.037743244,
-0.003315419,
-0.012039249,
-0.025281101,
-0.017338634,
0.00014567937,
0.047179054,
0.014986288,
-0.028651034,
0.006416087,
-0.01688931,
-0.0014132241,
-0.0092243645,
0.0009878528,
0.019730624,
-0.044985294,
-0.003587987,
-0.0024019028,
-0.002081429,
0.006990958,
-0.031241257,
-0.012548042,
0.022994833,
0.028122418,
0.014854134,
0.0008272028,
0.008636278,
-0.022994833,
-0.004813717,
-0.029708268,
-0.0219376,
0.0053522456,
-0.0149202105,
0.049716417,
0.029021066,
0.025386825,
0.009832273,
-0.011735294,
0.026681935,
0.01206568,
0.008933625,
-0.016876094,
0.026219396,
-0.02023281,
0.0021871522,
0.015937798,
0.01177494,
0.0036804948,
-0.014365163,
0.028888911,
0.023312004,
-0.018250497,
-0.025267886,
0.019479532,
-0.03443939,
-0.042342212,
-0.005137495,
0.011675825,
0.01786725,
-0.023734897,
-0.0005203572,
0.03515302,
-0.015382751,
0.024805347,
-0.012131757,
0.034016494,
-0.010261775,
0.020312103,
0.0019178881,
-0.00178243,
-0.017034678,
0.011801371,
-0.028492449,
-0.0029404312,
0.028651034,
-0.015303458,
0.01835622,
0.007076858,
-0.0070239967,
0.012878428,
0.004295012,
-0.035655208,
-0.018118342,
-0.0075856517,
-0.019862778,
0.0007925123,
-0.019228438,
-0.0070702503,
-0.03293283,
0.0013669701,
0.0017791261,
-0.007929252,
0.01737828,
-0.009336695,
-0.03636884,
0.018448729,
-0.0000419951,
0.036236685,
0.00012503027,
0.01564706,
0.056879174,
-0.0031882203,
-0.038774047,
-0.024091713,
-0.0055636927,
0.002241666,
0.0329064,
0.015422397,
-0.010096582,
-0.00019275931,
0.0105987685,
0.016995031,
-0.016810017,
-0.040994238,
0.00024180091,
0.008457869,
-0.0031849167,
-0.009065779,
0.026615858,
-0.010182482,
0.028016694,
-0.027778815,
0.011656002,
-0.001803905,
-0.008048192,
-0.021911168,
0.027091615,
-0.0006240157,
-0.0024498086,
-0.01584529,
0.009078994,
-0.004017488,
-0.008266246,
-0.0070636426,
-0.0029833815,
-0.0021855002,
0.03319714,
-0.014563395,
0.0050185565,
0.028413156,
-0.0011472638,
-0.011213285,
0.005140799,
-0.009515104,
0.04733764,
-0.023827406,
0.011867449,
-0.0030197238,
0.0070041735,
0.0057123657,
0.014695548,
-0.0033897555,
-0.027858108,
-0.028148849,
0.0038093452,
0.008570201,
0.018025834,
0.003541733,
-0.024844993,
-0.008153915,
-0.013056836,
-0.034677267,
-0.017959759,
0.015092012,
-0.043505166,
-0.008418224,
0.025637917,
0.027435215,
0.017761527,
0.026087241,
0.0010341067,
-0.011656002,
0.036236685,
-0.014074424,
0.02462033,
-0.0045527127,
0.0015445524,
-0.02915322,
0.014008347,
-0.023100557,
-0.03446582,
-0.007268482,
-0.040174883,
-0.009845489,
0.018884838,
0.01867339,
0.008332323,
0.016202107,
-0.010426967,
0.010645022,
-0.0126471585,
0.007486536,
-0.0038192568,
-0.014365163,
0.024461744,
-0.014906995,
-0.018276928,
0.005897382,
0.023298789,
0.019690977,
-0.0044436855,
-0.034624405,
0.037716813,
-0.013347575,
-0.006105525,
-0.008114269,
0.005553781,
-0.008424832,
0.0162814,
-0.022730526,
-0.020920012,
-0.016876094,
0.02132969,
-0.010281598,
0.002489455,
-0.020563196,
0.026774444,
-0.0035318213,
0.016439984,
-0.014061209,
-0.012937898,
0.0027554154,
-0.02571721,
-0.047839824,
0.0029602544,
-0.021805445,
0.027170906,
0.005418323,
-0.011398301,
-0.028016694,
0.029179651,
-0.041232117,
-0.036765303,
0.019016992,
0.031928457,
0.01916236,
0.037848968,
0.007843353,
0.0038258645,
-0.016268184,
0.016175676,
-0.021646861,
-0.027435215,
0.016677862,
-0.0055471733,
0.013638315,
0.026483705,
-0.02981399,
-0.015475258,
0.025941873,
-0.0007854916,
-0.028598173,
0.039381955,
-0.024712838,
0.016717508,
-0.018105127,
-0.0026430844,
0.0021161193,
0.009316872,
0.028571742,
-0.027038753,
-0.012409281,
0.015237381,
-0.006468949,
-0.014880565,
-0.004265277,
-0.0021987157,
0.011788156,
-0.0011745206,
-0.03134698,
-0.023800975,
0.0060857018,
0.0020450866,
-0.0052630417,
0.01784082,
-0.012766097,
0.008510731,
0.016545707,
-0.011999602,
-0.025822934,
-0.014523748,
-0.009039348,
-0.009713335,
0.006445822,
0.0016147593,
0.011510632,
-0.0027785425,
-0.003472352,
-0.014127285,
-0.0110480925,
-0.018858407,
-0.016149245,
-0.017655803,
-0.0029800776,
0.009541534,
-0.028598173,
-0.0066143186,
0.011827802,
-0.0067729037,
-0.01067806,
0.009065779,
-0.04202504,
-0.02981399,
0.019466316,
0.00972655,
-0.008259638,
-0.009746374,
-0.0063665295,
-0.004275189,
-0.03224563,
0.01151724,
0.169686,
-0.04049205,
-0.012092111,
0.020246025,
0.0024299857,
-0.004522978,
0.011695648,
0.0053026876,
-0.000114499235,
0.0076847677,
0.014100854,
-0.0036243293,
-0.025320748,
0.0030527625,
0.029523252,
-0.018567666,
-0.034994435,
-0.00958118,
-0.028122418,
0.008200169,
0.0044502933,
-0.008728785,
0.005590123,
-0.006693611,
0.008794863,
0.020417826,
-0.018157989,
0.0074997516,
-0.01339383,
0.020206379,
-0.032509938,
-0.0023820798,
0.005619858,
0.0115238475,
0.0022284505,
0.018990561,
0.012158188,
0.020008149,
0.014166932,
-0.016043521,
-0.0050548986,
0.007235443,
-0.0038225607,
-0.018263713,
0.014655902,
0.0028016693,
0.012468751,
-0.0034426174,
-0.017140402,
0.010103189,
-0.015303458,
0.027990263,
0.008537162,
0.031822734,
-0.005966763,
-0.0010910982,
-0.00020236115,
0.0068389806,
0.016836448,
0.037135333,
-0.028651034,
0.021184321,
-0.038377583,
0.033117846,
-0.02586258,
0.018250497,
-0.000936643,
0.010010682,
0.039963435,
-0.03227206,
0.010935761,
-0.013155952,
-0.009653865,
-0.00013359965,
-0.009290441,
-0.013387222,
0.034941573,
0.021950815,
0.020920012,
0.0065647606,
0.0035153022,
-0.019823132,
-0.017787958,
-0.018237282,
0.014484102,
-0.032404214,
0.026232611,
-0.014285871,
0.008213384,
-0.0066374457,
0.0056033386,
-0.018686606,
-0.011061308,
0.008550378,
-0.018263713,
-0.0013925751,
-0.0070900735,
0.006825765,
-0.015898151,
-0.017246125,
-0.03795469,
0.0495314,
0.0012546391,
0.016585354,
-0.009098818,
-0.002008744,
-0.012885036,
0.01772188,
-0.018990561,
-0.012343204,
0.007546006,
-0.0030478067,
0.018303359,
-0.016466415,
-0.0014346992,
0.027488077,
0.019003777,
-0.037161764,
0.012633943,
0.0067035225,
-0.019188792,
-0.028703896,
-0.0020450866,
0.0045857513,
-0.0113718705,
0.0011662609,
0.00075988675,
-0.000030792966,
-0.018290143,
-0.020946443,
-0.013929054,
-0.014550179,
0.019836348,
0.0055703004,
-0.006138563,
-0.035575915,
0.0006607711,
0.014153716,
-0.034386527,
0.011094347,
0.0047377287,
-0.011636179,
-0.00662423,
0.007083466,
-0.0092243645,
-0.0022647928,
0.01694217,
0.012131757,
0.0016618392,
-0.0038985494,
-0.028730325,
0.0047641597,
0.00095151033,
0.009131856,
0.007790491,
-0.0017246125,
0.00333359,
-0.041126393,
-0.028756756,
0.007882999,
-0.043161567,
-0.00065911916,
0.010142836,
-0.001141482,
-0.0060691824,
0.013083267,
-0.1665143,
-0.0024332895,
0.0032559494,
-0.025518978,
0.021408983,
0.030871226,
0.011193462,
-0.005144103,
0.013625099,
-0.009422596,
0.030395469,
0.010744138,
-0.031003378,
-0.01284539,
0.002489455,
-0.009660473,
-0.018845191,
0.029708268,
0.023721682,
-0.0070900735,
0.015462043,
-0.02132969,
0.0014462627,
-0.028307432,
0.0067596883,
0.010010682,
0.0014991243,
-0.026272258,
0.013981916,
-0.026298689,
-0.020616058,
0.007050427,
0.011219893,
-0.020576412,
0.010123013,
0.01769545,
0.0018237282,
-0.009951212,
-0.0275938,
0.018580882,
0.02430316,
0.03200775,
0.0004641917,
-0.0076451213,
0.00082637684,
-0.00037519407,
0.0134202605,
-0.00611874,
0.010222129,
-0.009792628,
0.010830038,
-0.011695648,
0.016122814,
0.016175676,
0.008391793,
-0.014299086,
-0.0032559494,
0.021567568,
0.010479829,
-0.0054711844,
-0.0023490412,
-0.011814587,
0.019320946,
0.014285871,
-0.002106208,
-0.02101252,
-0.002036827,
0.02320628,
-0.024541037,
-0.0030957125,
-0.02208297,
0.0022796602,
0.00868914,
-0.012805743,
0.008953448,
0.017959759,
-0.01394227,
0.014061209,
0.01215158,
-0.003150226,
-0.022439785,
0.016704293,
-0.03295926,
-0.007896215,
-0.005943636,
-0.020351749,
0.019228438,
0.022704095,
0.013387222,
-0.0006987654,
0.020906797,
-0.0025489244,
0.006528418,
-0.01616246,
0.02571721,
0.015501689,
0.000616582,
-0.032060612,
0.013076659,
-0.006554849,
0.028201709,
-0.028148849,
-0.0146691175,
0.010175874,
0.031505566,
0.014074424,
-0.018620528,
0.0027504596,
0.045513913,
0.010902722,
-0.01737828,
0.001803905,
-0.0021970638,
0.019981718,
-0.0017642587,
0.03171701,
-0.020589627,
0.0054480573,
-0.0042322385,
-0.022532294,
0.05428895,
0.0110547,
0.0013504509,
0.015369535,
-0.005808178,
0.000053790896,
-0.12771383,
-0.02332522,
0.019902425,
0.015594197,
-0.0026843825,
0.02398599,
-0.0045824475,
0.049637124,
-0.007493144,
0.038377583,
-0.0076451213,
-0.018567666,
0.01151724,
0.004437078,
0.004678259,
0.0024944108,
-0.006217856,
-0.008781647,
-0.010175874,
0.02851888,
0.017008247,
0.0013711,
0.012422496,
-0.024025636,
0.0072090123,
0.0027801944,
-0.03163772,
0.0076847677,
0.014325517,
-0.009574573,
0.011352047,
-0.028968204,
0.017061109,
-0.0018154685,
-0.022135831,
-0.0036276332,
-0.014153716,
-0.026655504,
0.040862083,
0.00305937,
-0.007037212,
0.005286169,
0.0012728103,
-0.014272655,
0.0069314884,
-0.017061109,
-0.004906225,
-0.0030494586,
-0.019334162,
-0.033302862,
-0.025955088,
-0.0113718705,
-0.006878627,
-0.006990958,
0.015620628,
0.00012946983,
0.013585453,
0.0037333565,
-0.002877658,
-0.007896215,
0.00721562,
-0.004952479,
-0.0048500597,
0.010261775,
0.02135612,
-0.01443124,
-0.02788454,
-0.019955287,
0.0300783,
-0.015726352,
0.0031337067,
0.01881876,
-0.0026199573,
-0.017497217,
-0.01757651,
0.0031403145,
-0.029206082,
-0.013730823,
0.010460006,
-0.0247657,
0.015184519,
-0.025955088,
0.02147506,
-0.0057156696,
0.009984251,
0.015025934,
-0.0006772904,
-0.0043676966,
-0.003885334,
-0.01647963,
-0.0022466218,
0.039355524,
-0.019188792,
0.000983723,
-0.014285871,
0.02430316,
-0.014510533,
-0.014008347,
0.016677862,
0.016664647,
-0.01090933,
-0.005596731,
-0.05989229,
-0.017325418,
0.008061407,
-0.012660374,
0.010955584,
-0.02113146,
-0.0062277676,
-0.009997467,
-0.012805743,
-0.0015016022,
-0.010856469,
-0.0036441525,
-0.029206082,
-0.0016411901,
-0.0074138516,
0.008616455,
0.029602544,
-0.0019393631,
0.027725954,
0.03200775,
0.008061407,
0.009713335,
0.022611586,
0.0139951315,
-0.0027322883,
0.0028660945,
-0.039910574,
0.01535632,
0.00799533,
-0.016810017,
0.0024432011,
-0.0065152026,
0.0040307036,
-0.00047823307,
-0.016572138,
-0.007988722,
-0.0025489244,
0.019347377,
0.018263713,
0.02822814,
-0.018025834,
-0.040174883,
0.0006479686,
0.012376242,
0.006029536,
0.013512769,
-0.032404214,
-0.017774742,
0.0010770569,
-0.013314537,
0.045276035,
0.009838881,
0.021607215,
-0.030395469,
-0.014351948,
0.0034426174,
0.0046881707,
-0.006825765,
0.016373908,
-0.021223966,
0.021673292,
0.022928756,
0.0070239967,
0.014550179,
-0.011616356,
0.009819058,
-0.028439587,
-0.027170906,
-0.007869784,
-0.024488175,
-0.02569078,
-0.0012595948,
0.01394227,
0.010076758,
0.0078763915,
-0.0135193765,
-0.021699723,
0.012369635,
-0.008193561,
0.012501788,
0.026589427,
-0.0022747044,
-0.0044205585,
0.008874156,
0.018831976,
0.0044899397,
0.0054678805,
0.012706628,
-0.009349911,
0.012957721,
0.0020682134,
-0.001162957,
0.009614219,
0.015184519,
-0.021025736,
0.013810116,
0.0058775586,
0.013076659,
0.014484102,
0.014735195,
-0.020708565,
-0.023734897,
0.000547614,
-0.025043223,
-0.014100854,
0.029073928,
-0.023919912,
-0.0410471,
0.007598867,
0.022875894,
0.014973072,
0.000105723375,
-0.013757254,
0.0056330734,
-0.013611884,
0.016730724,
-0.00095894403,
-0.007863176,
-0.03010473,
0.011332224,
0.011213285,
0.0073874206,
0.000034716293,
-0.004701386,
0.012224264,
0.019109499,
0.018686606,
-0.014550179,
0.019096283,
-0.007882999,
-0.0063434024,
0.014880565,
-0.016228538,
0.008656101,
-0.005418323,
0.004017488,
0.0005005341,
0.010367498,
0.0053621572,
0.079186805,
0.034042925,
-0.007836745,
0.0120722875,
-0.040571343,
0.02559827,
0.018303359,
0.02006101,
-0.0068654115,
-0.015237381,
0.015184519,
-0.034412958,
0.01723291,
-0.026311904,
-0.008827901,
0.026166534,
-0.018911269,
0.030976947,
-0.031082671,
-0.0048302365,
0.03253637,
-0.038007554,
0.007863176,
-0.012865213,
-0.0488442,
0.016056737,
0.022347277,
0.015435613,
0.008259638,
0.002012048,
0.009977643,
-0.013783685,
-0.045751788,
0.015316674,
0.0019492747,
0.016069952,
0.0024498086,
-0.02730306,
0.02854531,
-0.000109853194,
0.029232513,
-0.02915322,
-0.028915342,
0.013704392,
-0.0044734203,
-0.00031902854,
-0.018541235,
-0.00090277847,
-0.017497217
] |
The Protein Data Bank [PDB; Berman, Westbrook et al. (2000), Nucleic Acids Res. 28, 235-242; http://www.pdb.org/] is the single worldwide archive of primary structural data of biological macromolecules. Many secondary sources of information are derived from PDB data. It is the starting point for studies in structural bioinformatics. This article describes the goals of the PDB, the systems in place for data deposition and access, how to obtain further information and plans for the future development of the resource. The reader should come away with an understanding of the scope of the | [
-0.023624692,
-0.0064424844,
-0.0016519408,
-0.05329385,
-0.010267499,
0.023408819,
-0.013923862,
0.0018146894,
-0.018834991,
-0.0148278335,
0.004958352,
0.01863261,
0.02137151,
0.02220802,
-0.0011291213,
0.007994078,
0.017215937,
-0.022896118,
-0.021385001,
-0.002236318,
-0.016298475,
-0.011947268,
-0.014031799,
0.003344358,
0.008344873,
0.026849307,
0.020791348,
-0.030708052,
0.0042196587,
-0.027928676,
0.0007403798,
-0.0068708593,
0.000970589,
-0.013370685,
0.014557991,
0.008196459,
-0.010092102,
0.0024032828,
0.0114008365,
0.003771046,
0.018727055,
0.016554825,
0.00068641134,
0.012689333,
0.004256762,
-0.023624692,
0.017175462,
0.00085337623,
-0.021911195,
-0.00040455261,
-0.0030896943,
0.009518687,
-0.011974252,
-0.01601514,
-0.0019715352,
-0.030168368,
-0.016892128,
0.015421486,
-0.0022245124,
-0.02335485,
-0.00531252,
0.005919665,
-0.013161558,
-0.0052349404,
-0.023746122,
-0.0073329643,
0.0020879046,
0.02303104,
-0.0058387127,
-0.0017320502,
0.022828657,
0.01990087,
0.007683759,
0.024042947,
0.02578343,
0.001331503,
-0.015461964,
0.003767673,
-0.027766772,
0.0022902864,
-0.000025640287,
-0.0020153846,
0.009059954,
0.014085768,
0.004803193,
-0.0030542775,
0.016217522,
0.01780959,
-0.0027726295,
-0.018511182,
0.013370685,
0.036671568,
-0.0065605408,
-0.018996896,
-0.037508078,
0.012399253,
0.01748578,
0.037912842,
-0.009080193,
-0.016109584,
-0.025958829,
0.0102877375,
-0.018834991,
-0.01524609,
-0.010820676,
0.011346868,
0.0031149918,
-0.040017612,
0.00026752334,
0.0027102286,
-0.019792931,
0.041555714,
-0.00020902237,
-0.026404068,
0.01225084,
0.000977335,
0.027901692,
-0.012642112,
0.0071373284,
-0.0037980303,
0.03413505,
0.020332616,
0.015515932,
-0.016676253,
0.01317505,
0.0053833537,
-0.013734972,
0.0003588059,
0.016730221,
0.02234294,
0.0029564595,
0.030789005,
-0.00823019,
0.007677013,
-0.009262336,
0.014665929,
-0.007994078,
-0.01722943,
-0.0018585387,
-0.0502986,
0.030600116,
0.034350924,
-0.035916008,
-0.015421486,
-0.0068877246,
0.032947745,
0.010267499,
0.015718313,
0.014463547,
0.012223856,
0.04179857,
-0.010348451,
-0.006955185,
0.005299028,
-0.0076162987,
0.0080413,
-0.014396086,
0.013303225,
0.00093938847,
-0.014854818,
-0.006364905,
0.013707988,
0.006479588,
-0.01780959,
0.026673911,
0.042635083,
-0.004816685,
-0.008027808,
-0.0002671017,
0.0040577534,
-0.0019664757,
0.019388169,
-0.018915944,
0.005565497,
0.008547255,
0.022437386,
0.0012218796,
0.014773865,
-0.035727117,
0.01435561,
-0.004563708,
-0.03157155,
0.014935771,
0.01627149,
-0.016784191,
0.014112752,
0.030006463,
-0.010422658,
0.010888136,
-0.0058690696,
0.018335784,
-0.035565212,
0.01461196,
-0.0043916833,
-0.64718974,
-0.010530596,
0.0036158867,
-0.03669855,
-0.020319125,
0.03159853,
0.0002462311,
0.011272661,
-0.011427821,
0.0033291792,
0.004502993,
-0.00049330544,
0.013707988,
-0.021749288,
-0.023597708,
-0.008823843,
-0.0007568233,
-0.018133402,
0.017566733,
-0.005666688,
-0.022477863,
0.021304049,
-0.01928023,
0.014679421,
0.0006855681,
-0.011178217,
0.0096671,
-0.016150061,
-0.0057510138,
0.025662001,
-0.0125139365,
-0.010429405,
0.013566321,
-0.0018804634,
0.03950491,
-0.00012575072,
0.0036934663,
0.014045292,
0.030087415,
0.012480206,
0.0067932797,
-0.011495282,
0.024461204,
0.0134314,
-0.019361185,
0.017040541,
0.00941075,
0.01043615,
-0.013458384,
-0.00039612004,
-0.008135745,
-0.031625517,
-0.014139736,
-0.027901692,
0.016392918,
-0.00034278404,
0.022950087,
-0.023111992,
0.023759613,
0.0026444544,
0.03262393,
0.016865144,
-0.0046277954,
-0.02903503,
-0.025567558,
-0.017404828,
-0.019442137,
0.02705169,
0.0024184615,
0.0031183648,
0.021587383,
0.014881802,
0.009572655,
0.010753215,
0.0049347407,
0.027146135,
0.011744886,
0.01538101,
-0.020750873,
0.01755324,
0.00210477,
0.0032010041,
-0.024933428,
-0.0026124106,
0.023624692,
0.0193342,
-0.011630203,
0.017283399,
0.02143897,
0.0017590345,
0.0112929,
-0.012770287,
0.018511182,
-0.008095269,
-0.02417787,
0.023489771,
-0.013323463,
-0.035511244,
-0.0046143034,
-0.0010515417,
-0.015529424,
-0.006321056,
0.010739723,
-0.009457972,
0.033082664,
-0.0012379015,
-0.0056902994,
0.022869134,
0.04031444,
-0.0010287737,
0.0054912907,
-0.0089857485,
-0.014490531,
-0.012102427,
-0.004486128,
-0.031679485,
0.012925446,
-0.01716197,
-0.01748578,
-0.0013475249,
-0.014976247,
-0.015448471,
-0.002833344,
-0.0112929,
-0.008108761,
0.0045738267,
-0.0006476215,
-0.031085832,
-0.0042972383,
0.005066289,
0.0067764143,
0.009161145,
0.018713562,
-0.007670267,
0.02782074,
0.033838224,
0.009532179,
0.0072182813,
-0.012547666,
-0.030977895,
-0.023314374,
-0.014746881,
-0.0023206437,
0.00029514,
-0.020521507,
-0.020831825,
-0.025702478,
0.005332758,
0.015799265,
0.022181036,
-0.010328214,
-0.0015389443,
-0.011063534,
0.032435045,
0.0046277954,
-0.008979002,
-0.019415153,
-0.029844558,
-0.001672179,
0.016892128,
-0.026889784,
-0.015151644,
-0.0273755,
0.022801673,
-0.0062974445,
-0.01977944,
0.0028518958,
0.023017548,
-0.017027048,
-0.03151758,
0.009262336,
0.0034641004,
-0.025378667,
0.015448471,
-0.019469121,
0.034431875,
-0.006941693,
0.0052889087,
-0.0059567685,
-0.01011234,
-0.01295243,
-0.018861976,
0.008203206,
-0.008149237,
0.025000889,
0.028765189,
0.032462027,
0.0057274024,
-0.000024915613,
-0.010645279,
0.026120733,
0.0079738395,
-0.014571483,
-0.0057510138,
-0.02048103,
-0.027105657,
-0.0021621112,
0.0023290762,
-0.009350035,
0.027227087,
0.02208659,
0.007312726,
0.023881042,
-0.025985813,
-0.0020794722,
-0.02922392,
-0.00035817348,
-0.021992147,
-0.0023864177,
-0.0009975733,
0.014598467,
-0.0037474348,
-0.005194464,
-0.004108349,
0.011846077,
0.027658835,
0.007076614,
-0.0015035275,
-0.037885856,
-0.0009587834,
-0.003534934,
-0.0023273898,
0.029871542,
-0.010139324,
-0.024353266,
-0.007555584,
0.015799265,
0.032003295,
0.017526256,
-0.006233357,
0.009093685,
-0.0036867203,
-0.0022666752,
0.00094529125,
0.012244094,
0.009350035,
0.0155699,
-0.008250428,
0.026579466,
0.013202034,
-0.016541332,
0.004371445,
0.0122103635,
0.0022143933,
0.008527016,
-0.012055204,
0.008432572,
0.025621526,
-0.036779504,
-0.0052484325,
-0.011468297,
-0.0020912776,
-0.024002472,
0.008554,
-0.013303225,
-0.0075016157,
0.009498448,
0.009788529,
0.052079562,
0.0066111363,
0.016379427,
-0.000878674,
-0.0007585098,
0.0066988347,
0.024650093,
-0.028468361,
0.004381564,
-0.015192121,
-0.024407236,
0.010415913,
-0.021101667,
-0.019469121,
0.012675841,
-0.0015490634,
0.006732565,
0.0021688575,
-0.010726231,
0.0116032185,
0.01416672,
-0.0043242224,
-0.019050866,
-0.007980586,
-0.0032634053,
0.034890607,
0.005191091,
-0.031058848,
-0.020912778,
0.0037305697,
-0.029817574,
-0.01793102,
-0.019442137,
-0.01368775,
0.009215114,
0.009586147,
-0.007710743,
-0.027739787,
0.009862736,
-0.028009629,
-0.0003824171,
-0.0016772385,
0.0046716444,
-0.008506778,
0.01391037,
-0.0075083617,
0.045549378,
0.0040375153,
0.009302813,
-0.00132813,
0.0056093466,
-0.009235352,
-0.01320878,
0.00019437078,
-0.004951606,
0.0053529963,
-0.009316305,
-0.0019226263,
-0.0021604248,
0.022558816,
0.035322357,
0.009545671,
-0.0012227228,
-0.03642871,
-0.005062916,
0.020062774,
0.035403308,
0.02711915,
0.0032482266,
-0.0052450593,
-0.00017908674,
0.0023914773,
-0.0073936787,
-0.017620701,
0.008634953,
0.0068708593,
-0.0003704007,
-0.0071170903,
0.015205613,
0.01416672,
0.020184204,
0.0040375153,
-0.01928023,
-0.023449294,
-0.008790112,
-0.021169128,
-0.013046875,
-0.0044085486,
0.028387409,
0.040368408,
0.029088998,
0.0031166784,
0.009451226,
0.013923862,
-0.002548323,
-0.007677013,
-0.00066912454,
0.0072520114,
0.013552829,
0.010766707,
-0.016217522,
0.0006653299,
0.019428644,
0.0019108207,
0.008925034,
0.032839805,
-0.009005986,
-0.012682588,
0.007987332,
0.0031234245,
-0.004685137,
0.007656775,
0.00036934664,
0.007838919,
0.007198043,
-0.0029547731,
0.006499826,
-0.004196048,
-0.0041825552,
-0.03362235,
0.011670679,
-0.028171536,
0.0019462375,
-0.017000064,
-0.006041094,
-0.030330272,
-0.016784191,
-0.010429405,
0.0301144,
-0.02342231,
-0.004691883,
-0.00254495,
-0.022531832,
-0.0050123204,
-0.015394502,
-0.01524609,
0.012534174,
-0.035133466,
-0.020494523,
-0.008702414,
0.016069109,
0.009113924,
0.021411985,
-0.007683759,
0.001947924,
0.014153228,
-0.020197695,
-0.017175462,
-0.019374676,
-0.040800154,
0.0072857416,
0.022896118,
0.0018484197,
-0.022154052,
-0.0024994141,
0.025378667,
0.004823431,
-0.016028631,
0.010483373,
0.006857367,
-0.011259169,
0.026687402,
0.034404892,
0.03982872,
-0.011245677,
-0.03721125,
0.0057240296,
-0.0017404828,
-0.0044287867,
-0.014652437,
0.02073738,
-0.012325047,
-0.012932192,
0.0015811071,
0.0004882459,
-0.0008837335,
-0.0055992273,
-0.010840914,
0.018915944,
0.018969912,
0.014760373,
0.015219105,
0.006695462,
0.010867898,
-0.003082948,
-0.022046115,
-0.0038351335,
-0.024987396,
0.02992551,
0.024852475,
-0.012183379,
0.015974663,
-0.011569488,
-0.03375727,
-0.0059162923,
-0.013485368,
-0.020953253,
0.034431875,
-0.00995718,
-0.025297714,
-0.017256415,
0.0033561634,
-0.0024437592,
0.017283399,
-0.023476278,
-0.014976247,
0.010510357,
-0.016730221,
0.0097817825,
0.017310383,
-0.02674137,
-0.034081083,
-0.03534934,
-0.019253246,
0.0025803668,
0.033568382,
0.0022009013,
0.011367107,
0.012817509,
0.0062232376,
0.004954979,
-0.035565212,
-0.007555584,
-0.007042884,
0.0527002,
0.027281055,
0.030384243,
-0.005332758,
-0.0029362214,
0.024946919,
0.0026056645,
-0.0050426777,
-0.003416878,
-0.016231013,
-0.02890011,
0.004702002,
0.019819915,
0.007191297,
-0.014382594,
0.0020541744,
0.01435561,
0.009012733,
0.007940109,
-0.025108825,
-0.0034219376,
-0.033217587,
-0.0051202574,
0.020089759,
-0.013768703,
0.009842497,
-0.012075443,
-0.015731806,
0.014153228,
-0.024825491,
0.004715494,
-0.01317505,
0.014409578,
-0.0060714516,
0.024582632,
0.0075893146,
0.018403243,
-0.0054946635,
-0.017701654,
-0.026053272,
0.011738139,
0.018713562,
0.017283399,
0.02143897,
0.026201686,
-0.023314374,
0.004135333,
-0.008817097,
-0.013539337,
0.0079738395,
-0.023449294,
0.016028631,
-0.033217587,
-0.014841326,
-0.03534934,
-0.018713562,
0.023300882,
0.0079738395,
-0.009721069,
0.0268628,
-0.022410402,
-0.020669919,
0.023476278,
-0.01709451,
-0.0005974477,
-0.00028122627,
0.025054857,
0.054022428,
0.02015722,
-0.026646925,
-0.00013766173,
-0.0263501,
0.0029142967,
0.040692218,
0.008432572,
-0.0036732282,
-0.0306271,
0.0016055616,
0.006708954,
-0.005406965,
-0.032435045,
0.012972668,
0.008452809,
0.0015271388,
-0.008560747,
0.01589371,
-0.02525724,
-0.008695668,
-0.026876291,
0.013734972,
-0.0033966398,
-0.0263501,
0.010355198,
0.01435561,
-0.033784255,
0.021857226,
-0.0036496168,
-0.019469121,
0.0024252075,
0.009761545,
-0.022181036,
0.0014411265,
-0.0033797747,
-0.0033561634,
0.007771458,
-0.010375436,
0.0018062568,
0.02297707,
-0.0021570518,
0.019347692,
-0.01990087,
0.034620766,
-0.025108825,
-0.01735086,
0.0005080624,
-0.0047930735,
-0.0058016093,
0.01062504,
-0.008203206,
-0.038749352,
-0.024110408,
-0.007886141,
0.01362029,
0.016136568,
0.01940166,
-0.010213531,
-0.00008585412,
0.00054474414,
-0.014315133,
0.007926617,
0.0085674925,
-0.043147784,
-0.040746186,
0.006729192,
-0.019320708,
0.02195167,
-0.0046210494,
-0.005899427,
0.010274245,
0.020750873,
-0.018146893,
0.0055958545,
0.010989327,
0.012129411,
-0.06800026,
-0.009990911,
-0.031355675,
-0.01671673,
0.0043208497,
-0.010321467,
-0.0049347407,
0.0039498163,
0.0009832379,
0.027550898,
0.011663933,
-0.0044422788,
0.031625517,
-0.0063041905,
0.0072385194,
-0.00054980366,
-0.022531832,
0.013937354,
-0.007177805,
0.009457972,
-0.007069868,
-0.014315133,
0.0023830447,
0.0246366,
-0.013040128,
-0.0027490184,
-0.040341422,
-0.030708052,
-0.006867486,
0.019725472,
-0.013046875,
0.0059230383,
-0.0090734465,
-0.010065117,
-0.011954013,
0.018133402,
0.016055616,
0.011852822,
0.004094857,
0.010092102,
0.012372269,
-0.019320708,
-0.040341422,
0.00091493403,
0.005754387,
-0.021290557,
-0.02085881,
0.002374612,
-0.025351683,
0.03367632,
0.022923103,
-0.031544562,
-0.023624692,
0.01486831,
-0.024083424,
-0.0003056807,
0.0065268106,
0.030842973,
0.021938179,
0.010213531,
0.015529424,
0.030006463,
-0.009255591,
0.021587383,
-0.011724647,
-0.027469944,
0.01928023,
-0.013856402,
0.052619245,
0.010746469,
-0.024083424,
-0.0051742257,
-0.0060680783,
-0.0140183065,
-0.008209951,
0.019995313,
0.010233769,
0.019037373,
-0.0016645896,
0.025756447,
0.003007055,
0.030168368,
0.016123077,
-0.021398494,
-0.011043295,
0.02405644,
-0.0085674925,
-0.011245677,
0.011866314,
0.0021266944,
0.011319884,
0.004917876,
0.0010802124,
-0.008594477,
-0.0032161828,
-0.006921455,
0.0049010105,
0.010598056,
-0.018915944,
0.024123902,
0.0012817509,
0.016217522,
0.0029632056,
0.0054676794,
-0.03718427,
0.0072857416,
-0.0029648922,
-0.0018585387,
0.014989739,
-0.02833344,
0.0028974316,
-0.023638185,
0.0018062568,
-0.01103655,
-0.010044879,
-0.02871122,
0.014908787,
0.0091544,
-0.0047762087,
-0.019307217,
-0.01196076,
-0.036509663,
0.0016392919,
0.015354026,
-0.013195288,
-0.021196112,
0.010719485,
-0.006675224,
-0.025675494,
0.0042803735,
0.01856515,
0.02245088,
-0.021911195,
-0.022599291,
0.19029278,
-0.016311966,
0.01965801,
0.035457276,
-0.00033350821,
-0.019995313,
-0.025621526,
0.0010220277,
-0.005164107,
-0.006975423,
0.008446064,
0.027038198,
-0.025594542,
0.008203206,
0.037885856,
-0.0039194594,
-0.029520746,
-0.025027873,
-0.01940166,
0.015718313,
0.00034847602,
-0.0064087543,
-0.0022261988,
-0.003000309,
0.018511182,
-0.00048149982,
-0.006995661,
0.005973634,
0.009120669,
0.018133402,
0.011157978,
-0.014922279,
-0.0067393114,
-0.0129186995,
-0.005919665,
0.0036833473,
-0.0023628066,
-0.021573892,
0.011562742,
0.0008289218,
-0.008027808,
0.005069662,
-0.010152816,
-0.033325523,
0.020804841,
-0.021776272,
-0.0020912776,
-0.0019276858,
-0.0068978434,
0.014045292,
-0.04058428,
0.016730221,
0.010456389,
0.0031723334,
-0.0018130029,
-0.021142144,
0.0017944513,
0.022032622,
-0.007569076,
0.008284158,
-0.021560399,
0.004725613,
-0.019293724,
0.008655191,
-0.020777857,
-0.011650441,
-0.009039717,
0.041636664,
0.0096671,
-0.038938243,
-0.0059432765,
0.018025465,
-0.032893773,
0.017391335,
-0.023557233,
-0.013539337,
0.032785837,
0.04951606,
0.025230253,
0.005518275,
-0.011529012,
-0.00093770196,
-0.00601411,
0.011475043,
-0.025581049,
-0.010341706,
0.018592134,
-0.017593717,
-0.0075083617,
-0.028927093,
-0.0011755005,
-0.0066381204,
-0.013316717,
0.0152325975,
0.0049920822,
-0.005079781,
-0.01844372,
0.020521507,
-0.0037946573,
-0.01755324,
-0.013067113,
0.08883208,
0.0032583456,
0.019239755,
-0.028468361,
-0.012014728,
-0.0138294175,
0.029439794,
-0.014288149,
0.006020856,
0.013080605,
-0.031247737,
0.0013298165,
-0.018713562,
-0.009397258,
0.04282397,
0.014247673,
-0.025756447,
0.031409644,
-0.019509597,
-0.016892128,
-0.029763604,
0.0018248084,
0.018227847,
-0.0059365304,
-0.0051438687,
0.007825427,
-0.0034775925,
0.018781023,
-0.030546147,
-0.0026191566,
0.0051371227,
0.008931779,
0.012938938,
-0.009194876,
0.007029392,
0.0035922755,
0.002711915,
-0.023192944,
0.011792108,
-0.022275481,
-0.017108,
0.005197837,
0.0129186995,
0.02648502,
0.008938526,
-0.0063176826,
0.0052619246,
0.011987744,
0.015947679,
-0.0022160797,
-0.022531832,
-0.00631431,
-0.014544499,
0.000549382,
-0.0005080624,
-0.014625452,
-0.024204854,
-0.02450168,
0.002173917,
-0.008938526,
0.0042837462,
0.04090809,
-0.0049920822,
0.003410132,
-0.0006940006,
-0.1716197,
0.013040128,
0.011819093,
-0.022518339,
0.018659594,
0.011130994,
0.014031799,
0.01926674,
0.016743714,
-0.006607763,
-0.0074678855,
-0.0026883038,
-0.013330209,
-0.018389752,
0.0006252752,
0.012392507,
0.012972668,
0.017108,
0.0051404955,
0.0020642935,
0.0067764143,
0.013795687,
0.008864319,
-0.026768355,
0.0080413,
0.036293786,
-0.00046885098,
0.0071373284,
-0.002020444,
-0.017404828,
-0.008756382,
0.012655604,
0.035376325,
0.0043107304,
0.019765947,
-0.0047660894,
0.015340534,
0.00037820084,
-0.017769115,
0.010254007,
-0.0011721274,
0.051755752,
0.0085674925,
-0.015488948,
0.026768355,
0.015583392,
0.019455628,
-0.023314374,
0.019604042,
-0.01837626,
0.030573132,
0.0051202574,
0.029709635,
0.009788529,
0.023516756,
0.0150572,
-0.004718867,
0.018025465,
-0.020440554,
-0.01926674,
-0.009754798,
0.004229778,
0.008189714,
-0.015731806,
0.00579149,
-0.01384291,
-0.012898461,
0.0049887095,
-0.02705169,
0.004951606,
-0.008661938,
-0.029682651,
0.005258552,
-0.013681004,
-0.0029345348,
-0.0042196587,
-0.009329797,
0.019469121,
0.012007982,
-0.012891715,
0.010058371,
-0.0062974445,
0.0005236627,
-0.010537341,
0.02545962,
-0.006712327,
-0.0012193498,
0.0263501,
-0.0007829643,
-0.005993872,
0.010604802,
-0.02137151,
0.012520682,
0.002597232,
0.0060984357,
0.021587383,
-0.0050325585,
0.019050866,
-0.011029803,
0.0020862182,
0.024137393,
0.009532179,
-0.00003228094,
0.019091342,
0.0060849437,
0.010132578,
-0.010989327,
-0.006142285,
0.029682651,
0.014854818,
-0.043741435,
0.013377432,
0.013478623,
0.010874644,
-0.0049988283,
0.02647153,
-0.010125832,
-0.0041994206,
-0.022383418,
-0.05086527,
0.039450943,
0.029520746,
-0.013573067,
0.0043984293,
-0.014814341,
-0.018268323,
-0.11117502,
-0.029196935,
0.016028631,
-0.0013483682,
-0.000398439,
0.0050190664,
0.0055014095,
0.03516045,
-0.004830177,
0.029115982,
-0.012824255,
0.014058784,
-0.00023822015,
-0.017782606,
-0.0025871128,
0.013809179,
-0.017512765,
-0.004094857,
-0.02756439,
0.015691329,
0.0012303122,
0.012554413,
0.007838919,
-0.0013905311,
0.019104835,
0.0036900933,
-0.027159626,
0.021061191,
0.024326282,
-0.014692913,
0.009505195,
-0.009849244,
0.0065504215,
-0.017593717,
-0.014665929,
0.0027237206,
-0.0030981267,
-0.031625517,
0.031760436,
-0.00010951802,
-0.008196459,
-0.013546083,
0.022869134,
-0.013249257,
0.018200863,
-0.0098829735,
-0.009228607,
0.008250428,
-0.0072317733,
0.014288149,
-0.01531355,
0.007177805,
-0.0068944707,
0.012277824,
0.007542092,
0.007919871,
-0.017755622,
0.0119944895,
-0.01298616,
-0.0016983199,
-0.004034142,
0.017782606,
-0.026754864,
0.015650854,
-0.0000010771292,
-0.02010325,
-0.022194529,
-0.015043708,
0.027105657,
-0.038128715,
0.006482961,
0.015542916,
-0.02111516,
-0.019428644,
-0.0030053684,
0.0036631091,
-0.03286679,
0.008021062,
0.019185787,
-0.018173879,
0.011900045,
-0.023219928,
-0.026255654,
-0.002281854,
0.00564645,
0.024811998,
0.0138294175,
0.004583946,
0.02270723,
-0.04366048,
0.0035045766,
0.037346173,
-0.0029783843,
0.0025145928,
-0.0067797876,
0.023004055,
-0.01683816,
-0.022477863,
-0.017269906,
0.01928023,
-0.052349404,
0.009977419,
-0.06254944,
0.01940166,
-0.0043208497,
-0.005066289,
0.004229778,
0.014409578,
-0.009754798,
0.0009486643,
0.021722304,
0.012777032,
-0.024852475,
-0.0074139168,
-0.00531252,
-0.014854818,
-0.026174702,
-0.024717554,
0.028468361,
-0.0007420663,
0.0036091406,
0.022491354,
-0.0053766076,
0.0024235211,
0.044766836,
0.011009566,
-0.013087351,
-0.007103598,
-0.019806424,
0.02270723,
-0.00077326683,
-0.016109584,
-0.014652437,
-0.035565212,
-0.011373852,
0.013013144,
-0.0058454587,
-0.028414393,
-0.02022468,
0.011279408,
0.0263501,
0.04039539,
-0.028846141,
-0.042904925,
0.0005502253,
-0.004155571,
0.007103598,
-0.013390924,
-0.03203028,
-0.0020744125,
0.007548838,
-0.034890607,
0.048517644,
0.006614509,
0.0020676665,
-0.02513581,
0.002659633,
0.019563565,
-0.0019108207,
0.009896466,
0.00343037,
0.002374612,
0.028171536,
0.009417496,
0.007521854,
-0.0049279947,
0.0008432572,
0.0053226394,
-0.009255591,
-0.008257174,
0.015488948,
-0.01914531,
0.002701796,
0.021223096,
0.016865144,
0.008493286,
0.037589032,
-0.01524609,
-0.026822323,
0.012561158,
-0.0012024847,
0.011211948,
0.035835057,
-0.005673434,
0.0052619246,
0.0053968458,
0.03955888,
-0.015205613,
0.005272044,
0.020265156,
0.011340122,
-0.012372269,
-0.0032212422,
0.026147718,
-0.0042972383,
0.019927854,
0.018092925,
0.012142903,
0.010125832,
-0.028036613,
0.02424533,
0.02992551,
-0.0018096298,
0.01298616,
-0.0007884454,
-0.053266868,
-0.03459378,
0.018942928,
-0.027024705,
-0.026687402,
0.0030323528,
-0.0031048728,
0.002809733,
-0.0016384487,
-0.033730287,
0.0040476345,
-0.003170647,
0.019792931,
0.012021474,
0.0028013003,
-0.009802021,
0.017081017,
0.004691883,
0.02380009,
-0.012068696,
-0.0014352236,
0.0013340329,
0.01589371,
0.035403308,
-0.031247737,
0.013869894,
-0.02169532,
-0.023530247,
-0.010975835,
0.0083651105,
-0.018484198,
-0.0034809655,
-0.0019394915,
-0.004718867,
-0.0029429675,
-0.0034843385,
0.06719073,
0.022896118,
0.0029193563,
-0.0051539876,
-0.023867551,
-0.0007087576,
0.0035821565,
0.009471464,
-0.00016359189,
-0.014989739,
0.027429469,
-0.000026588952,
-0.0005236627,
-0.018969912,
0.014665929,
0.017445303,
-0.025284223,
0.015003231,
-0.030465195,
0.004870653,
0.025567558,
-0.022504847,
-0.007670267,
-0.004121841,
-0.02941281,
0.011724647,
0.0018770904,
-0.01196076,
0.014274657,
-0.021573892,
0.02424533,
0.013060367,
-0.043039843,
-0.008594477,
0.010935359,
-0.010679008,
-0.018740548,
-0.0052214484,
-0.0009925136,
0.00922186,
-0.0018399871,
-0.00023505793,
-0.01774213,
-0.015812758,
-0.0096940845,
0.0017438558,
-0.010874644,
-0.042338256,
-0.010719485
] |
The balance between oxidative and nonoxidative glucose metabolism is essential for a number of pathophysiological processes. By deleting enzymes that affect aerobic glycolysis with different potencies, we examine how modulating glucose metabolism specifically affects hematopoietic and leukemic cell populations. We find that a deficiency in the M2 pyruvate kinase isoform (PKM2) reduces the levels of metabolic intermediates important for biosynthesis and impairs progenitor function without perturbing hematopoietic stem cells (HSCs), whereas lactate dehydrogenase A (LDHA) deletion significantly inhibits the function of both H | [
-0.010585837,
0.00077987846,
0.029402163,
-0.055575646,
-0.03255145,
0.023222681,
-0.016619764,
-0.0067186984,
-0.021925915,
-0.01255745,
0.020523291,
0.007886449,
0.0043071127,
-0.0062721088,
-0.018511983,
-0.012722853,
0.037659116,
-0.014912798,
-0.0061397855,
0.015759666,
-0.027655499,
0.017493095,
-0.002280917,
-0.019001577,
0.009229527,
0.02725853,
0.01034104,
-0.03278963,
-0.008548063,
-0.0141188605,
0.027232066,
-0.013060276,
-0.003929992,
0.009553718,
0.0026084164,
-0.010506444,
0.0058222106,
-0.002762242,
-0.008051853,
-0.00024541776,
0.004283956,
0.018975113,
-0.01348371,
-0.014343809,
0.005534408,
-0.0063647344,
-0.0024678232,
-0.017823903,
-0.0030235797,
0.029984383,
-0.00829665,
0.004059007,
0.010738009,
0.0047570104,
-0.0066359965,
-0.012312652,
0.0049323384,
0.005517868,
-0.0088590225,
-0.0141188605,
0.005355772,
-0.009242759,
-0.027999539,
0.005937993,
0.0044361274,
0.0031095897,
0.0052896105,
0.008746548,
0.011796593,
-0.0141188605,
0.03450983,
0.006169558,
-0.009467708,
0.0029673425,
0.01305366,
-0.026623381,
-0.027840752,
-0.022283187,
0.0034139324,
-0.010023464,
0.025908837,
-0.020496827,
-0.017982692,
0.03244559,
0.008561295,
-0.013265377,
-0.00081461325,
-0.0029574183,
0.023593185,
0.028052468,
-0.0023867756,
0.0030450823,
0.04316375,
0.02217733,
-0.028475901,
0.00024583127,
-0.006288649,
0.042211026,
0.011571643,
-0.004833096,
-0.03268377,
0.012266339,
-0.010565989,
-0.02160834,
-0.03456276,
-0.012299419,
-0.0030186176,
0.0042211027,
0.008911951,
0.0069734203,
-0.015693504,
0.029640345,
-0.0029491482,
-0.04528092,
0.0043038046,
0.011479017,
0.011578259,
0.003122822,
-0.03607124,
-0.0023983538,
0.023553487,
0.020655615,
0.015203909,
-0.028793477,
0.009302304,
0.007807055,
0.00053425395,
0.006530138,
-0.016553603,
-0.011141594,
0.0138277495,
-0.0015564489,
0.0013893911,
-0.004594915,
-0.015137747,
0.015389161,
-0.019477941,
-0.0056898873,
-0.0144629,
-0.035541948,
0.0020774705,
0.024056315,
-0.009593415,
-0.004773551,
-0.01624926,
0.023976922,
0.035991848,
-0.0043534255,
0.010453514,
-0.018525215,
0.01930592,
-0.0072645308,
0.028026003,
-0.023381468,
0.026239645,
0.012286187,
0.014145325,
0.03424518,
-0.037420936,
-0.018710468,
-0.012100935,
-0.031042967,
0.016355118,
0.007132208,
0.0062357197,
0.020232182,
0.0024827097,
0.011975228,
0.009725738,
-0.025141364,
0.009692657,
0.032392662,
-0.025247222,
0.017254915,
-0.01647421,
0.027152672,
0.0032071779,
0.01918683,
-0.025339847,
-0.014251184,
0.015058354,
0.03215448,
0.008600993,
0.02148925,
-0.012841944,
0.024598839,
0.020655615,
-0.021237835,
0.0095603345,
-0.008455438,
0.013880679,
0.020986423,
-0.0072976113,
-0.023593185,
-0.64065486,
-0.029190445,
0.013788053,
-0.021079049,
0.002191599,
0.027549641,
0.033318922,
-0.009566951,
0.0017665116,
0.021476017,
0.006162942,
0.015918452,
0.00083735626,
-0.027549641,
-0.011326846,
-0.04109951,
-0.008614225,
-0.02148925,
0.01722845,
-0.013668962,
-0.011750279,
-0.005498019,
-0.025736816,
0.0019302613,
-0.00009872534,
0.033954073,
0.044619303,
0.0017020041,
0.003397392,
0.040332038,
-0.024188638,
0.02217733,
-0.027840752,
0.008190791,
0.052002925,
0.013668962,
-0.018710468,
0.02633227,
0.002811863,
0.03405993,
-0.0030301958,
0.009368466,
0.014039466,
0.013159519,
0.0030947034,
0.019213295,
-0.000009620551,
-0.0078666005,
-0.00055699697,
-0.0029408778,
0.014436436,
0.004154941,
-0.010195484,
-0.0029706506,
0.006788168,
0.010473363,
0.019094205,
-0.019729353,
-0.00038683793,
0.019504406,
0.0043600416,
0.014595223,
-0.005765973,
-0.0019434935,
-0.028899336,
-0.0021849829,
-0.014701081,
0.0011942148,
-0.016897643,
-0.003430473,
0.017493095,
0.006834481,
-0.006295265,
0.012478055,
0.027893681,
-0.0010031735,
0.018022388,
0.015349464,
-0.010453514,
0.011975228,
0.012008309,
0.0024347426,
-0.013139671,
0.0024016618,
0.018710468,
-0.004565142,
-0.028343579,
0.008819326,
-0.0011660961,
0.000623572,
0.0301961,
0.016924107,
-0.011254068,
-0.04419587,
-0.018247336,
0.018578144,
-0.020126322,
0.018075317,
0.030434282,
-0.04620718,
-0.023328539,
-0.010830634,
0.015177444,
-0.0013472132,
0.014198254,
0.017916529,
-0.053114437,
-0.0165933,
0.035118517,
-0.023751972,
0.016844714,
-0.017823903,
-0.0006893199,
0.0066326885,
0.010923261,
-0.011796593,
0.016394814,
-0.0127162365,
-0.0065797595,
-0.033662964,
0.014092396,
0.018564912,
-0.0010395623,
-0.007125592,
-0.004684233,
0.029137516,
0.013576336,
-0.007859984,
-0.005921453,
-0.0077011967,
-0.0072049852,
0.010255029,
0.03498619,
-0.027417319,
0.021621572,
-0.009977152,
0.023527022,
-0.0023470786,
0.017321076,
-0.03133408,
-0.021806825,
-0.027629035,
-0.020880563,
-0.008620841,
-0.010665231,
0.001117302,
-0.022733085,
0.0076482673,
0.032577913,
0.017942995,
-0.013748356,
-0.0068212487,
-0.027086511,
0.0072976113,
0.002636535,
-0.0073836213,
-0.019372081,
-0.0030616226,
-0.019438244,
0.0069403397,
-0.0013190946,
0.013490327,
0.0074233185,
0.025670655,
-0.017241683,
-0.016103705,
-0.01712259,
-0.005415317,
-0.023976922,
-0.02011309,
-0.0109629575,
-0.012961035,
-0.017731277,
-0.008111398,
-0.004859561,
0.0048694853,
-0.0070660464,
0.0059016044,
-0.009957303,
0.0013761588,
0.02420187,
-0.0057825134,
-0.029111052,
0.006444128,
0.010069777,
0.03686518,
0.02437389,
0.020046929,
-0.014423203,
0.030963574,
0.0013157865,
0.033689428,
-0.01935885,
-0.013682195,
0.0077872067,
-0.025710352,
-0.01492603,
-0.010929877,
-0.02028511,
0.036388814,
0.035541948,
-0.052743934,
0.0028002847,
-0.00258526,
0.026464593,
-0.018803094,
-0.003349425,
-0.0183135,
0.010248413,
0.016011078,
-0.003526407,
0.00723145,
-0.0131926,
-0.0035991846,
-0.005666731,
-0.004555218,
-0.007899681,
-0.011459169,
-0.014608455,
-0.014912798,
0.014211486,
-0.024122477,
0.018564912,
-0.026027927,
0.011359926,
0.017254915,
-0.004422895,
0.015839059,
-0.01654037,
-0.01578613,
-0.012325884,
0.007846752,
0.008620841,
-0.0020113091,
0.0013323269,
0.030910645,
0.001740047,
0.0010139247,
0.04223749,
-0.009772051,
0.006473901,
0.0023536948,
0.016619764,
-0.010466746,
-0.006920491,
-0.006781552,
0.03959103,
-0.004829788,
-0.037156288,
0.01221341,
-0.024903182,
0.014687849,
-0.0047801672,
0.0011115129,
0.0073902374,
-0.008574528,
0.0068874103,
0.016685925,
0.02684833,
0.0251149,
-0.0063250377,
-0.0026993884,
-0.011220987,
-0.02471793,
-0.027655499,
0.0003886987,
0.01590522,
-0.006953572,
0.012458207,
-0.0061464016,
-0.04567789,
-0.012636843,
-0.01118129,
-0.03813548,
0.013291841,
0.006202639,
0.021767128,
0.0058155945,
0.02201854,
0.013682195,
0.0052995346,
-0.016090473,
0.029587414,
0.020880563,
-0.023037428,
-0.020761473,
-0.036150634,
-0.014952495,
-0.00011733326,
0.012292803,
0.015071586,
-0.0007091684,
-0.007820287,
0.0029392238,
-0.03151933,
-0.014992191,
-0.00009107542,
-0.011531946,
0.028158328,
0.004763627,
-0.024665,
0.02449298,
-0.020166019,
-0.0052168327,
0.043190215,
0.015375929,
-0.0039928453,
-0.0018144787,
0.0029656885,
-0.03424518,
0.016196331,
-0.008190791,
0.017506327,
-0.015309767,
-0.010704928,
0.017903296,
-0.012987499,
0.008528215,
0.013893912,
-0.0024198561,
-0.025313383,
-0.0369975,
0.0042773397,
-0.010056545,
0.014449668,
0.019755818,
-0.009566951,
0.017254915,
-0.009997,
0.01169735,
0.0079790745,
-0.011055584,
0.025617726,
-0.015375929,
-0.002461207,
0.019504406,
0.0037083512,
0.0029094513,
0.0009039313,
0.022455208,
0.011247452,
-0.020761473,
-0.006245644,
0.014423203,
0.008104782,
-0.02518106,
0.017440166,
0.032816093,
0.028740548,
0.020893795,
0.009520637,
0.0030219257,
0.0067120823,
-0.0060636997,
-0.012471439,
0.030513676,
0.008131246,
0.0076945806,
-0.013999769,
-0.013265377,
0.028502367,
-0.024982575,
0.014886334,
0.008071701,
0.026663078,
0.013139671,
0.016103705,
0.015931685,
0.0052962266,
-0.016990269,
-0.007588722,
0.025154596,
0.0038638306,
-0.023010964,
0.033398315,
-0.013404316,
-0.024731163,
-0.010248413,
0.027470248,
0.0110820485,
-0.00093783904,
0.012755934,
-0.0073902374,
0.0075821057,
-0.0025654114,
-0.020126322,
0.018789861,
-0.0031889835,
-0.0015729893,
0.016355118,
-0.004674309,
-0.018445821,
-0.034324575,
-0.012564066,
0.01123422,
-0.010996038,
-0.038161945,
-0.0030301958,
0.022838945,
0.037076894,
0.02696742,
-0.037950225,
-0.0019980767,
0.0020013847,
-0.028449437,
-0.006559911,
0.003038466,
-0.025445705,
0.011935531,
-0.016752087,
-0.011776743,
-0.016209563,
-0.018948648,
-0.0016151672,
0.008614225,
-0.0068014003,
-0.017651884,
0.008230489,
-0.019967536,
-0.001249625,
0.0102021005,
0.024135709,
0.0007885622,
-0.0015696812,
-0.006874178,
-0.01561411,
-0.012180329,
-0.020523291,
-0.03284256,
-0.024043083,
-0.001604416,
-0.00093866605,
0.019782282,
-0.009031042,
0.021356927,
-0.002502558,
0.015547948,
0.022534601,
0.010387353,
0.018988345,
0.009130284,
0.007635035,
0.0073968535,
0.00010172328,
-0.009117052,
-0.022441974,
0.022058237,
0.015150979,
-0.0016705774,
0.013152903,
-0.0033246146,
-0.041231837,
-0.011015886,
-0.0020956649,
-0.016738854,
0.034324575,
-0.0013025542,
-0.0003554112,
-0.023685811,
-0.007932762,
-0.007092511,
0.007410086,
0.0030913954,
-0.0070263497,
-0.011935531,
0.018472286,
0.005759357,
-0.010797554,
0.029746203,
-0.034589224,
-0.030434282,
-0.002406624,
-0.008574528,
0.011710582,
-0.010493211,
0.0048893336,
-0.033213064,
-0.021568643,
-0.00948094,
-0.020324808,
0.010301343,
-0.011862754,
0.033557102,
0.046921723,
0.031201756,
0.0012727815,
0.024387123,
0.00035830578,
0.006189407,
0.0008691965,
-0.00018339136,
-0.00055575644,
-0.01762542,
0.009375082,
0.0029210295,
0.0025670654,
0.0012198524,
-0.008806094,
0.02102612,
0.016050776,
-0.005848675,
-0.01336462,
0.0018624457,
-0.03278963,
-0.021131977,
0.02926984,
-0.039326385,
-0.002414894,
-0.018260568,
-0.016791785,
0.03186337,
0.0016325345,
0.0037579723,
-0.0043633496,
0.020708544,
-0.022971267,
0.03636235,
0.0024661692,
0.0033791978,
0.007767358,
-0.032022156,
0.0043931226,
-0.011823057,
0.0025786438,
-0.0073505407,
0.007588722,
-0.009732354,
-0.03424518,
-0.0012355656,
0.0050580455,
-0.023804901,
-0.010274878,
-0.028026003,
-0.027655499,
-0.005230065,
0.01054614,
-0.014793707,
-0.021383392,
0.0047140056,
0.020867331,
-0.010771089,
0.0070660464,
-0.016434513,
-0.021171674,
0.04366658,
-0.0018624457,
0.012405278,
-0.015746433,
0.03249852,
-0.0006620283,
-0.000102705366,
-0.023355003,
0.00589168,
-0.0053359237,
-0.004416279,
0.01671239,
-0.0008398373,
-0.013616033,
-0.00525653,
0.0061364775,
-0.019120669,
-0.0014754011,
-0.010810786,
0.017995924,
-0.020046929,
-0.012114167,
-0.008442205,
-0.0040788553,
-0.012894873,
0.007284379,
-0.0036388815,
0.029296305,
0.0025703737,
0.0011263993,
0.0042177946,
0.03130761,
0.017876832,
-0.019266224,
-0.0014332231,
-0.015918452,
-0.002901181,
-0.024056315,
-0.02437389,
0.026716007,
-0.010625534,
0.031095896,
-0.0071719047,
0.0038175175,
-0.0026629996,
-0.013920376,
0.0051142825,
-0.0014828442,
-0.003440397,
0.036282957,
0.007959226,
0.006437512,
0.030301958,
0.007019733,
0.006381275,
0.0020873947,
-0.0033791978,
-0.019927839,
-0.0301961,
0.017651884,
0.020814402,
0.011836289,
-0.02183329,
-0.015891988,
-0.033318922,
-0.015918452,
-0.036971036,
-0.036044776,
0.01602431,
-0.033054277,
0.0020692004,
-0.0058784476,
0.003972997,
-0.007932762,
0.0028631382,
-0.0070660464,
-0.013232296,
0.031836905,
-0.012855176,
0.048139095,
0.015071586,
-0.007363773,
-0.0018740239,
0.0068477136,
-0.040332038,
-0.017254915,
0.01100927,
-0.004919106,
-0.045016274,
-0.003170789,
0.0020162712,
0.010314575,
0.020152787,
-0.007019733,
-0.001208274,
-0.0029276456,
0.037368007,
-0.0007852541,
-0.0068874103,
0.017268147,
-0.037579723,
-0.009401547,
0.012048006,
-0.00008161639,
-0.009573567,
-0.009983768,
-0.009520637,
-0.0076548834,
0.00740347,
-0.021846522,
-0.01221341,
0.013093357,
-0.0013075162,
0.021793593,
0.0059578414,
-0.01861784,
-0.019451477,
-0.0023487327,
0.020668847,
0.005769281,
-0.017929763,
-0.011366542,
-0.000980844,
0.02021895,
-0.024440052,
0.006460669,
-0.0072446824,
-0.020020464,
-0.018459054,
-0.0030169636,
-0.008653922,
0.03750033,
-0.0074894796,
-0.012431743,
-0.022574298,
0.004836404,
-0.03122822,
-0.022045005,
-0.0020195793,
0.0178636,
0.023024196,
0.033318922,
-0.0050679697,
-0.016566835,
-0.004680925,
0.023182983,
-0.011293765,
-0.010010232,
0.011015886,
0.0058155945,
0.030275494,
-0.017413702,
-0.008693619,
-0.012967651,
0.009646344,
-0.0086803865,
0.0042674155,
0.030143172,
-0.0083297305,
0.016963804,
-0.0048066317,
0.014198254,
0.026980653,
0.025551565,
-0.009083971,
-0.026186714,
-0.014978959,
0.014171789,
-0.0071586724,
0.0151112825,
-0.010526292,
0.0021320537,
-0.024942879,
0.017982692,
0.0012107551,
-0.010129323,
0.012266339,
-0.0016689234,
0.0048727933,
0.013589568,
0.0015853945,
0.009540486,
0.0108438665,
0.000333702,
0.004584991,
-0.00016478344,
0.0029541103,
-0.0058883717,
0.013602801,
0.013430781,
-0.011247452,
0.008409125,
0.008111398,
-0.022031773,
-0.0034437052,
-0.0019004886,
-0.021740664,
-0.023831366,
0.018287033,
-0.013146287,
-0.010129323,
0.0006157153,
0.013788053,
-0.005855291,
0.002502558,
-0.004247567,
-0.003081471,
0.011796593,
-0.016606532,
0.007807055,
-0.004419587,
-0.0020989731,
0.0017549333,
-0.02080117,
-0.005137439,
0.015164211,
0.17392531,
-0.014912798,
0.0130073475,
0.011737047,
0.013920376,
-0.029455092,
0.007529177,
-0.013893912,
0.0005222622,
0.0042078705,
0.03308074,
-0.01884279,
-0.01746663,
-0.0074762474,
0.015164211,
-0.0017499712,
-0.029534485,
-0.012266339,
-0.013616033,
-0.019808749,
-0.0075027123,
0.00038249607,
0.016328653,
-0.010579221,
0.018234104,
0.014661385,
-0.006880794,
0.022799246,
0.035303768,
0.005352464,
-0.0071520563,
0.026398432,
-0.012279571,
0.0006516906,
0.010486595,
0.010691696,
-0.004326961,
-0.016778551,
0.01815471,
0.002145286,
0.006874178,
0.016632996,
-0.0027010425,
0.009123668,
-0.013351387,
0.0114327045,
-0.015468555,
0.0027936685,
-0.013602801,
-0.0068080164,
-0.047874447,
-0.0102021005,
0.022971267,
0.018353196,
0.010724776,
0.013377852,
0.015944917,
0.007800439,
-0.018181175,
0.034589224,
-0.034483366,
-0.003253491,
-0.012815479,
0.013060276,
-0.0057362006,
0.018392893,
-0.033265993,
-0.027920146,
0.0050679697,
-0.014873101,
-0.005001808,
-0.013589568,
0.0058883717,
-0.0061497097,
0.003963073,
-0.013073509,
0.009428011,
0.016394814,
-0.011220987,
0.011393007,
-0.005091126,
-0.0022478364,
-0.019861678,
0.0055674887,
-0.009461092,
-0.026768936,
0.011690734,
0.014621688,
-0.03636235,
-0.0030169636,
0.022084704,
-0.0047570104,
-0.013880679,
0.013291841,
-0.006834481,
-0.010949725,
0.007674732,
0.006960188,
-0.004237643,
-0.030672463,
-0.030434282,
0.08256953,
-0.006827865,
0.011677502,
-0.005183752,
0.0034503213,
-0.013166135,
0.010413817,
-0.019001577,
0.00024190292,
0.018181175,
-0.041284766,
-0.0030765089,
-0.00043004964,
-0.016831482,
0.009937455,
0.004508905,
-0.008514983,
0.018763397,
-0.010559373,
0.00097340083,
-0.000017522456,
0.017294612,
0.025286919,
0.0073836213,
0.015018657,
-0.04038497,
-0.008548063,
-0.017718045,
-0.013840982,
-0.0072976113,
0.0005950398,
0.0032055238,
0.017823903,
-0.0020774705,
-0.0046279957,
0.016791785,
0.00829665,
-0.0033146902,
0.019160366,
-0.020152787,
-0.012564066,
-0.0013281917,
0.022574298,
0.0108438665,
-0.035065584,
0.018578144,
0.000045124198,
-0.01867077,
-0.020483594,
-0.015495019,
-0.045307383,
-0.01884279,
-0.009520637,
0.012888256,
-0.004730546,
0.0025521792,
-0.023831366,
0.006827865,
0.02137016,
-0.019636728,
0.046471827,
0.008475286,
-0.02518106,
0.001611032,
-0.013305075,
-0.16609178,
-0.005441782,
0.004158249,
-0.030143172,
0.021687733,
0.014965727,
0.012802247,
-0.021224603,
0.0013943532,
-0.0020410817,
0.040596686,
-0.028502367,
-0.049303535,
-0.017612187,
-0.009229527,
-0.002004693,
-0.0037281995,
0.03847952,
0.007013117,
0.0017466631,
0.011373159,
0.010102859,
0.028422972,
-0.0023007656,
-0.0009601685,
-0.012921338,
0.019279456,
0.014449668,
-0.016064009,
-0.014436436,
-0.035409626,
0.014105628,
0.011770127,
0.03411286,
0.012894873,
-0.007992307,
0.0064904415,
-0.011743663,
0.00850175,
-0.00365873,
0.024056315,
0.008481902,
-0.012100935,
-0.009977152,
-0.0043898146,
0.05335262,
0.0069072586,
0.0149392625,
0.01259053,
0.0120744705,
0.020602686,
0.008045237,
-0.0068477136,
0.01688441,
0.004555218,
0.0085083665,
-0.0062390277,
-0.0023024196,
0.000849348,
-0.0034271649,
-0.0036421895,
-0.02667631,
-0.0020410817,
0.0023966997,
-0.0038075934,
-0.007906297,
0.023659347,
0.01740047,
-0.016685925,
0.014595223,
-0.025167828,
-0.0075688735,
0.017069662,
0.01480694,
0.023884295,
-0.012888256,
-0.002317306,
0.011115129,
0.009143516,
0.0055410243,
0.0028217873,
0.009388315,
-0.044857483,
-0.020364504,
-0.008839174,
0.02442682,
0.020166019,
0.017757742,
0.00093039585,
-0.010599069,
0.005683271,
-0.034007,
0.0064474363,
-0.022627227,
0.011703966,
0.022547834,
-0.0026166865,
-0.016143402,
0.0049488787,
0.016619764,
0.010585837,
-0.008911951,
-0.017413702,
-0.008600993,
0.033292457,
0.009216295,
-0.014357042,
-0.0017516252,
0.046577685,
0.003840674,
-0.020377737,
0.0015539678,
0.011862754,
0.022217026,
0.00047636268,
0.024347426,
0.011068816,
-0.024532678,
-0.011439321,
-0.021277532,
0.06462654,
-0.016685925,
-0.014105628,
0.04948879,
-0.0042740316,
-0.03424518,
-0.13592215,
-0.037129823,
-0.004836404,
-0.0014299151,
0.014674617,
0.022031773,
-0.013033812,
0.00927584,
0.0012372197,
0.024532678,
-0.04880071,
0.000025456664,
0.00472393,
0.0015134439,
0.016116938,
-0.022097936,
0.0059479172,
-0.009725738,
-0.016778551,
0.037606187,
-0.009778667,
0.0047967075,
-0.018115014,
0.0037182753,
0.008746548,
0.003301458,
-0.024532678,
0.024572374,
0.013516791,
0.010175636,
0.02990499,
0.0023603109,
0.014621688,
-0.0075225607,
-0.0018326731,
0.00884579,
0.019213295,
-0.034959726,
0.032657307,
-0.0027407394,
-0.018803094,
0.01781067,
0.020615919,
-0.009864677,
0.014304113,
0.004009386,
-0.032233875,
0.005590645,
0.010645382,
-0.020443898,
-0.040702544,
-0.01016902,
-0.030487211,
-0.016580068,
0.023368236,
-0.016765319,
0.027973074,
0.03474801,
-0.014171789,
-0.002408278,
0.004684233,
0.001118956,
-0.00064466096,
0.00850175,
0.017016733,
-0.027046815,
-0.022481672,
-0.044963345,
0.020099858,
-0.028449437,
-0.005934685,
0.0074762474,
-0.011419472,
-0.019597031,
-0.017387237,
0.009394931,
-0.006702158,
-0.0099705355,
-0.0053293076,
-0.012663308,
-0.009540486,
-0.014714314,
0.012689772,
-0.016765319,
0.023699043,
0.0028813325,
0.01238543,
0.018511983,
0.01224649,
0.0023536948,
-0.01068508,
0.04620718,
0.012650075,
-0.015931685,
-0.010698312,
0.01336462,
0.013668962,
-0.013430781,
0.016752087,
0.017426934,
-0.006867562,
-0.0118958345,
-0.04776859,
0.008726699,
-0.000069521244,
0.004012694,
0.006516906,
-0.017043198,
-0.008481902,
-0.010049929,
0.0044295113,
0.019557334,
-0.0015820864,
0.008660538,
-0.017334308,
-0.008435589,
-0.014449668,
-0.02143632,
0.02092026,
-0.0037116592,
0.0069734203,
0.023579953,
-0.0041747894,
-0.0053359237,
0.004766935,
0.02114521,
0.011101897,
-0.014198254,
-0.029190445,
0.026001463,
0.006788168,
-0.03284256,
0.015931685,
-0.04747748,
-0.012153864,
-0.010579221,
-0.014714314,
-0.019716121,
-0.005613802,
0.0108571,
0.014092396,
0.03797669,
-0.0036521137,
-0.0047503943,
-0.0023090357,
-0.015812594,
-0.00085100206,
0.006834481,
-0.035409626,
0.006649229,
0.0005818075,
-0.01224649,
0.045783747,
-0.009540486,
0.00714544,
-0.045492634,
-0.0005164731,
-0.0073505407,
0.002279263,
-0.009553718,
-0.014740778,
-0.012974267,
0.013166135,
0.009904374,
0.00033349523,
-0.019372081,
-0.0016556911,
-0.028158328,
-0.002145286,
-0.006291957,
-0.0012603762,
-0.029402163,
-0.025088435,
0.007879833,
0.0251149,
0.007290995,
0.015190677,
0.0013331539,
0.0138277495,
0.023209449,
0.0016283995,
0.02056299,
0.016791785,
-0.024876717,
-0.019372081,
0.024122477,
0.03498619,
-0.016408047,
-0.009930839,
0.049700506,
0.00047140056,
0.0018425973,
0.013305075,
0.016831482,
0.014489365,
0.012808863,
0.029058123,
0.02275955,
0.010116091,
-0.0032005617,
0.0021932533,
0.040808402,
-0.017426934,
0.0047867834,
-0.004161557,
-0.013748356,
-0.01688441,
0.027033582,
-0.034192253,
-0.016236028,
-0.010255029,
0.0062291035,
0.010764473,
0.022230258,
-0.0065466785,
0.0006599608,
-0.0068940264,
-0.00072033313,
-0.02569712,
-0.0027060045,
-0.009540486,
0.023606418,
0.015984613,
0.002590222,
-0.0027705121,
-0.0041218605,
0.028237721,
0.017149055,
0.034377508,
-0.0103211915,
0.022746317,
0.006606224,
0.02921691,
-0.0070263497,
-0.052002925,
-0.021330463,
-0.0083297305,
-0.012974267,
0.0087399315,
0.018644305,
-0.0037281995,
0.08553357,
0.005488095,
-0.022944802,
-0.02131723,
0.0014323961,
0.013880679,
0.0077011967,
-0.001741701,
-0.008184175,
-0.021065816,
0.012312652,
-0.014820172,
0.017995924,
-0.043004964,
-0.01463492,
0.023355003,
-0.0012554141,
0.013530023,
0.011095281,
-0.009348618,
0.0095007885,
0.00013118582,
0.0052763782,
0.011022503,
-0.023249146,
-0.01751956,
0.041152444,
-0.011730431,
0.021462785,
-0.024453284,
0.01636835,
-0.0035528715,
-0.03750033,
-0.005759357,
0.022627227,
0.009686041,
-0.0038042853,
-0.024863485,
0.02794661,
0.01896188,
-0.0048066317,
0.0019004886,
-0.011611341,
-0.025366312,
-0.018750165,
-0.028819941,
-0.012147248,
-0.005412009,
-0.014820172
] |
Rhythmic oscillations shape cortical dynamics during active behavior, sleep, and general anesthesia. Cross-frequency phase-amplitude coupling is a prominent feature of cortical oscillations, but its role in organizing conscious and unconscious brain states is poorly understood. Using high-density EEG and intracranial electrocorticography during gradual induction of propofol general anesthesia in humans, we discovered a rapid drug-induced transition between distinct states with opposite phase-amplitude coupling and different cortical source distributions. One state occurs during unconsciousness and may be similar to sleep slow oscillations. A second state occurs at the loss or recovery of consciousness and resembles an enhanced slow cortical potential | [
-0.00258063,
-0.013041098,
0.013821679,
-0.033538096,
-0.008350878,
0.018559003,
0.006604663,
0.009118002,
-0.009245856,
-0.013835138,
0.025274696,
0.023619326,
0.023619326,
0.0031206445,
-0.009353522,
0.0037043984,
0.040455665,
0.00527902,
-0.023107909,
-0.0011103102,
-0.025234321,
0.021788996,
-0.0054573426,
-0.0019279022,
-0.0073886095,
0.02437299,
0.011614517,
-0.018828169,
-0.020079792,
-0.0021802455,
0.026216777,
0.0016461189,
-0.015019468,
-0.0070723393,
0.0038726272,
-0.02715886,
0.0018252826,
-0.005218458,
0.011412643,
0.0024662344,
0.0048248023,
0.0074424427,
-0.01787263,
0.014198512,
0.004757511,
0.008512378,
0.004074502,
-0.0026849317,
-0.004518626,
0.02555732,
0.012287432,
0.042285994,
-0.017468879,
0.004811344,
0.029635187,
-0.035529926,
-0.01643259,
0.024117282,
0.012691181,
-0.032784432,
0.00983802,
-0.00599231,
-0.013693825,
0.009541938,
0.005272291,
-0.003960106,
0.008000962,
0.008593128,
0.019151168,
-0.010578227,
0.05081856,
0.02579957,
-0.029043023,
-0.01991829,
0.017118964,
0.0049425624,
-0.018007211,
-0.0011447971,
0.005659217,
0.004670032,
0.006473445,
-0.030361935,
-0.036525838,
0.047696233,
-0.002107907,
0.012374911,
-0.014077387,
0.012347994,
-0.0029271813,
0.013754387,
0.013660179,
0.028127857,
0.013310264,
0.024023075,
0.011701996,
0.015746217,
-0.008048066,
0.016338382,
-0.017899545,
0.005416968,
0.0041956264,
0.008546024,
-0.024628699,
-0.01580005,
-0.033134345,
-0.017764963,
0.009353522,
0.01841096,
0.014898344,
-0.01508676,
0.0060865185,
0.0059048315,
0.0038457105,
-0.036229756,
-0.008727711,
0.016338382,
0.004693584,
0.008323962,
0.006534007,
-0.025180489,
-0.0045960112,
0.034641676,
0.016782505,
-0.01214612,
-0.0034352324,
0.009972604,
-0.013471764,
-0.011722184,
-0.017172797,
-0.022085078,
-0.01159433,
0.005087239,
0.0042191786,
0.012973806,
-0.0137813045,
0.027858691,
0.0042292723,
-0.012415286,
-0.013364097,
-0.025072822,
-0.0008499761,
-0.0034991594,
-0.022879118,
-0.02088729,
-0.010012979,
0.049741894,
0.022852201,
0.006517184,
0.017509256,
0.0062682056,
0.013276618,
0.0029843792,
-0.008613315,
0.00085922866,
0.008088442,
-0.003268686,
0.014413845,
0.034991592,
-0.023255952,
-0.02357895,
-0.007644317,
0.0023972606,
0.011917329,
0.010060083,
0.018262919,
0.0007204399,
0.02239462,
-0.0016074263,
0.014050471,
-0.011345351,
-0.012233599,
0.009676522,
-0.032757513,
0.025530405,
-0.0014577026,
-0.0003295182,
0.004303293,
0.012899785,
-0.051491473,
-0.033618845,
-0.0028884886,
0.019083876,
0.007819275,
0.00678635,
0.005709686,
0.012045183,
0.044977654,
-0.021533288,
-0.00658784,
-0.0032131702,
-0.02834319,
0.010127375,
-0.018451337,
0.0019464074,
-0.63178664,
-0.008808461,
0.0155847175,
-0.049391977,
0.0035126177,
0.008633503,
0.0033494357,
-0.002552031,
-0.003778419,
0.01714588,
-0.012913244,
0.026257154,
0.0060360497,
-0.020173999,
-0.002848114,
-0.014360012,
0.00090002414,
-0.0036976694,
0.006732517,
-0.009407355,
-0.008283586,
-0.0122807035,
-0.026459027,
0.0203355,
0.0003669491,
0.023955783,
0.017455421,
0.008613315,
-0.0058947373,
0.012879598,
-0.012469119,
0.01563855,
0.004010575,
-0.01730738,
0.059378043,
-0.00881519,
0.0026714734,
0.03189618,
0.0054674363,
0.03962125,
-0.013808221,
-0.017347755,
0.031761598,
0.009279502,
-0.027441483,
0.004044221,
-0.00678635,
-0.021021873,
0.0041081477,
-0.027804857,
0.0017495797,
0.016782505,
-0.00496275,
0.024951696,
0.0034957947,
-0.021560205,
0.013465034,
-0.01819563,
-0.0009176882,
0.028235523,
0.010625332,
-0.00841817,
-0.0012776979,
-0.020860372,
-0.020658499,
0.01785917,
-0.0056894985,
-0.02215237,
0.017899545,
0.016607549,
0.004643115,
0.014346553,
0.012745014,
-0.015154052,
0.006173997,
0.011473205,
0.007280943,
0.005581832,
-0.003100457,
-0.0011229273,
-0.013094931,
0.023646241,
-0.03676809,
0.0023669794,
0.008990148,
0.006540736,
-0.009326605,
-0.0065777465,
-0.0076712337,
-0.02612257,
0.0066584963,
0.015329009,
0.0077923588,
-0.032999765,
-0.01429272,
0.029554438,
-0.004915646,
0.00897669,
0.038463835,
-0.015032927,
-0.0021651047,
-0.017293923,
-0.013512138,
0.0047911564,
0.024103824,
-0.0046565733,
-0.0003354062,
-0.009824563,
0.04476232,
-0.01874742,
0.0049122814,
-0.015975008,
0.00369094,
-0.013148764,
-0.00028830214,
-0.02715886,
-0.0005833334,
0.024938239,
0.008478732,
-0.026055278,
0.009266043,
-0.014804135,
0.012314349,
-0.012173037,
0.007233839,
0.014696469,
-0.0018219181,
0.005527999,
-0.019433793,
0.0014762079,
-0.004421053,
-0.013370826,
0.006241289,
0.0061336225,
-0.007018506,
-0.0053799576,
0.016446048,
-0.004239366,
-0.018384045,
-0.025355447,
-0.037683252,
-0.0041888976,
0.0017310744,
-0.023390533,
0.0019329491,
-0.0067829858,
-0.05857054,
0.0003004987,
0.0062682056,
0.0020103343,
0.0076645045,
-0.017038213,
-0.019339584,
0.0062211016,
0.008559482,
-0.003724586,
-0.0151271345,
-0.0062446534,
-0.010665706,
-0.023148285,
0.024951696,
0.006143716,
-0.028935356,
0.014831052,
-0.022461912,
-0.018114878,
0.0029339106,
-0.0131083885,
-0.022058161,
-0.024722906,
0.0024897864,
-0.01722663,
0.021533288,
0.016244175,
0.0032384046,
0.024695989,
-0.0024258594,
-0.021721704,
-0.0061639035,
-0.007832734,
0.013411201,
0.016069217,
-0.01310166,
0.004407595,
0.030711852,
0.011002164,
0.033834178,
-0.010578227,
-0.022879118,
0.0320846,
0.0059182895,
0.042743575,
-0.019097334,
-0.00539678,
-0.027751025,
-0.0048449896,
-0.0066080275,
0.010679165,
0.012448932,
0.028208608,
0.023107909,
-0.018034128,
0.0030752227,
0.0069512143,
0.021869745,
-0.028100941,
-0.0050132186,
-0.0074693593,
0.019420333,
-0.0011776016,
-0.02461524,
-0.012691181,
0.016903631,
-0.034910843,
-0.020173999,
0.014346553,
-0.013539054,
0.007893296,
0.005353041,
-0.0061807265,
0.028477773,
0.012630619,
0.022663785,
0.021573663,
-0.003707763,
0.015544342,
0.0066282153,
-0.0017764963,
0.005137708,
-0.002873348,
-0.008848836,
0.027777942,
0.006883923,
0.024992073,
0.0054102386,
0.0055751028,
-0.008552752,
-0.010759915,
0.037817836,
0.01476376,
-0.0008655372,
0.031142518,
0.019205,
0.01151358,
-0.012321078,
-0.013431388,
0.034399427,
-0.0038087002,
-0.000589642,
0.0033023315,
-0.012677724,
0.00041888974,
-0.019877916,
0.004491709,
0.0027942806,
-0.002901947,
-0.0045791883,
0.020173999,
0.021465996,
0.03851767,
-0.012583515,
0.015342467,
0.009575584,
-0.013875512,
-0.017711129,
0.019501084,
0.0073415055,
-0.00023131461,
-0.038383085,
-0.007213651,
-0.023767367,
0.00928623,
0.017186256,
-0.0238212,
0.021183372,
-0.0049291044,
-0.0014198512,
-0.0029288635,
0.01777842,
0.019743333,
-0.024978613,
-0.031169435,
0.009710167,
0.04247441,
-0.002393896,
-0.003596732,
0.0017664025,
-0.00023930549,
-0.003748138,
0.011183851,
-0.011580871,
0.0058846436,
-0.028639274,
-0.013633263,
-0.016499883,
-0.0062042787,
0.010807019,
0.01841096,
-0.0057231444,
-0.03571834,
-0.013222785,
0.018074503,
-0.03151935,
-0.00012007332,
0.024480656,
0.0045522717,
-0.010894498,
-0.01865321,
0.008761357,
-0.010524394,
0.009831292,
0.017495796,
0.0102619575,
-0.0015678925,
0.009535209,
0.00802115,
-0.0017933191,
-0.0056020194,
0.032703683,
-0.009938958,
0.012368183,
-0.0023434274,
-0.010854123,
-0.015786592,
0.0320846,
0.01071954,
-0.0012877915,
0.026001446,
-0.0011431148,
-0.018801251,
-0.024547948,
-0.017724587,
0.0072203805,
0.01944725,
-0.028773855,
-0.011143477,
0.023686616,
0.011668351,
0.0042999284,
0.017616922,
0.009434272,
-0.006671955,
-0.016540257,
0.02644557,
0.016970923,
0.011607788,
0.02675511,
0.06653786,
-0.0024157658,
-0.008943044,
0.014642635,
0.014777219,
-0.01651334,
-0.018545544,
-0.015032927,
0.02421149,
0.011977891,
0.0024796927,
0.0025940882,
-0.015773132,
-0.0016393898,
0.010389811,
-0.0007730114,
0.0011776016,
0.0054674363,
0.05749388,
0.004636386,
-0.024224948,
0.018922377,
-0.030335018,
0.0053732283,
0.02993127,
-0.015611634,
-0.00499976,
0.015517426,
-0.0019043501,
0.011977891,
-0.012670994,
0.004747417,
-0.010194666,
-0.0000019977172,
0.0001689648,
-0.009239126,
0.004178804,
-0.009831292,
-0.011728913,
-0.012085558,
-0.01079356,
-0.0052386452,
-0.010981977,
-0.00865369,
-0.01698438,
-0.024117282,
0.007994233,
0.0051814476,
-0.035610676,
-0.03216535,
0.0031576548,
0.041801494,
0.018370586,
0.015773132,
-0.004804615,
0.002802692,
-0.01032252,
-0.005464072,
0.0020120165,
-0.014965635,
-0.0243057,
-0.00040837543,
-0.01874742,
0.022798369,
-0.013848595,
0.006325403,
0.016298007,
0.012596973,
-0.018774336,
0.024830572,
0.012139391,
0.0008016103,
0.010807019,
0.0239827,
0.027495317,
0.008909398,
-0.016715216,
0.030065853,
-0.032057684,
-0.0046498445,
-0.012462391,
0.0062278304,
0.0018185534,
0.013902429,
-0.004044221,
-0.012960347,
-0.0137813045,
-0.0076241298,
-0.029069938,
0.0011204039,
0.0015502285,
0.03741409,
0.009851479,
-0.0039365543,
0.016782505,
-0.010214853,
-0.007758713,
0.0069915894,
0.006322039,
0.026499402,
0.003194665,
-0.03590676,
0.024023075,
0.0032232641,
-0.006604663,
-0.016365299,
0.011890412,
-0.019810624,
0.02715886,
-0.015046385,
-0.03189618,
-0.008155732,
0.011446289,
0.00001234116,
0.013808221,
-0.011210768,
0.0018471524,
-0.0010674119,
0.0014349917,
0.0031223267,
-0.018626293,
0.037817836,
-0.03563759,
-0.0009589042,
-0.011399184,
-0.018478252,
0.04255516,
-0.012300891,
-0.0030180248,
-0.01683634,
-0.006453257,
-0.012354724,
-0.030684935,
-0.012644078,
-0.034910843,
0.021398704,
0.022246579,
0.050145645,
0.030604186,
0.0035058884,
0.053860135,
-0.007900025,
-0.020375874,
-0.004740688,
0.0019682772,
-0.010268686,
0.022569578,
0.0064633507,
0.003251863,
-0.0056659463,
-0.010854123,
0.026607068,
0.017105505,
0.0013853642,
-0.024251865,
-0.017711129,
-0.0030920457,
-0.033995677,
-0.00033919135,
-0.0046633026,
-0.012119204,
-0.03620284,
-0.018087963,
0.024709448,
0.012509494,
-0.0033544826,
-0.041343912,
0.021048788,
-0.0038389815,
0.013242972,
-0.001465273,
0.032326847,
-0.018949293,
-0.022502286,
-0.013283347,
0.00070277584,
0.010665706,
0.013411201,
0.012953619,
0.0050434996,
0.008768085,
-0.017751504,
-0.006123529,
-0.02072579,
0.008943044,
-0.0080615245,
-0.041909162,
-0.003684211,
-0.010618603,
-0.017213171,
-0.023794282,
-0.031761598,
0.018464794,
-0.017011298,
0.03509926,
-0.018034128,
-0.009279502,
0.025301613,
0.006581111,
0.03184235,
-0.02715886,
0.01865321,
-0.00706561,
-0.011796204,
-0.004246095,
-0.023780825,
0.0047810627,
-0.013269888,
0.012024996,
0.0052689263,
-0.033618845,
-0.014723386,
0.009777458,
0.0066080275,
-0.027993275,
-0.03526076,
-0.004952656,
-0.004747417,
0.005154531,
-0.008155732,
-0.0066753193,
-0.015234801,
0.015059844,
-0.0144542195,
0.003980294,
0.0020507092,
-0.022098538,
-0.03367268,
0.005598655,
-0.023901949,
0.0056222067,
0.0041081477,
0.024682531,
0.0128930565,
-0.008754628,
-0.030469602,
0.011789475,
0.00082263886,
0.011170393,
-0.002949051,
-0.003818794,
-0.004834896,
0.0027639994,
-0.0018841627,
-0.010672436,
-0.029043023,
0.03590676,
-0.010376353,
-0.012415286,
0.021708246,
0.0034301854,
0.019151168,
-0.025772654,
-0.015746217,
-0.0023030525,
-0.008034608,
0.008599857,
0.016459506,
-0.008983418,
-0.018155253,
-0.014884885,
-0.005501082,
-0.0052756555,
-0.029096855,
-0.0038860855,
0.0009824563,
-0.03612209,
-0.0018606107,
0.011069456,
0.012926701,
0.006392695,
-0.0035227113,
0.000677121,
-0.02215237,
-0.0072674844,
-0.01254314,
0.023942325,
0.01833021,
0.023323242,
-0.016782505,
0.004421053,
-0.022771452,
-0.010100458,
0.011937517,
-0.024130741,
-0.038490754,
0.01492526,
0.0065239132,
0.022542661,
-0.007011777,
0.0032266285,
-0.009313147,
0.025032448,
0.00007381039,
0.017482338,
-0.031761598,
-0.007967317,
-0.020133624,
-0.012206683,
0.038006254,
-0.037118006,
-0.011964433,
-0.0023619325,
0.004818073,
0.03009277,
-0.04048258,
0.012058641,
0.009817833,
0.031034851,
-0.022973327,
0.00046052638,
0.0063321325,
-0.009111272,
-0.024386449,
0.018882003,
-0.009622688,
0.0059519354,
-0.011405913,
-0.027401108,
-0.009481376,
0.0048281667,
-0.0015216296,
0.010181207,
0.019353043,
-0.028450856,
-0.05208364,
0.010093729,
-0.016499883,
0.033995677,
0.019851,
-0.029204521,
-0.0068906522,
-0.019420333,
0.006375872,
0.008983418,
0.004787792,
0.024507573,
0.00460274,
0.006766163,
-0.010120645,
0.0160423,
0.021614037,
0.022596493,
0.014427302,
0.0029692384,
0.017818796,
-0.020429706,
-0.00928623,
-0.003596732,
-0.051491473,
0.017832253,
0.006719059,
0.0020927663,
0.0071665472,
0.016082674,
0.011715454,
-0.013007452,
0.02589378,
-0.0013189139,
-0.030361935,
0.019151168,
0.005605384,
-0.03375343,
0.026082195,
0.0130478265,
0.011789475,
-0.019245377,
0.016607549,
0.01055804,
-0.014279261,
-0.0030937279,
-0.042582076,
-0.019312667,
0.02690315,
-0.018222544,
0.024588322,
0.019474167,
-0.009716896,
-0.001518265,
0.017980296,
-0.0013214373,
-0.020079792,
-0.013687097,
-0.0061840913,
-0.0042528245,
0.019097334,
-0.015988465,
0.011634705,
0.004192262,
0.025987986,
-0.012179766,
-0.008169191,
-0.023807742,
0.01627109,
-0.025382362,
0.019272292,
0.013424659,
-0.022596493,
0.030846436,
-0.021842828,
-0.00277914,
-0.021950494,
-0.0059687584,
0.0037615963,
-0.021250663,
0.014992552,
-0.011049269,
-0.01421197,
0.013821679,
-0.020523915,
-0.016540257,
-0.0002885124,
0.022246579,
0.18669361,
-0.007314589,
-0.009043981,
-0.0014509734,
-0.009871666,
0.00019325285,
-0.00042204402,
0.005652488,
-0.0059115603,
0.0131689515,
0.014050471,
-0.00085334067,
-0.025368905,
-0.0060663307,
-0.007967317,
0.006520549,
-0.015167509,
-0.016944006,
0.00944773,
-0.0014425621,
0.020025957,
-0.011076185,
0.013599617,
0.0029995197,
0.027024277,
0.0030466237,
0.009245856,
-0.0055549154,
0.002708484,
0.011089643,
-0.027078109,
0.021008413,
0.010840665,
0.011903871,
-0.025288155,
-0.0068771937,
-0.007018506,
-0.019339584,
-0.00064852205,
-0.012812306,
0.0044311467,
-0.0058308104,
-0.0023282866,
-0.016028842,
0.025180489,
0.00575679,
0.00865369,
-0.016405674,
0.02612257,
-0.0026462392,
-0.040805582,
-0.00026285753,
0.0043234807,
0.045273736,
-0.0036572944,
-0.001319755,
0.014494594,
0.032273017,
-0.0013727471,
0.030523436,
-0.021533288,
0.019945208,
-0.0023215576,
0.015692383,
-0.000017808597,
0.02976977,
0.007900025,
0.0057904357,
0.022286953,
-0.011244413,
0.010517665,
0.0014879839,
-0.016849797,
-0.00032804618,
-0.0028834417,
-0.021008413,
0.038006254,
0.025463114,
0.020994956,
0.019339584,
0.0037515026,
0.0005042659,
-0.014360012,
-0.019487625,
-0.012879598,
-0.0033898104,
0.03518001,
0.014360012,
-0.014602261,
0.014144679,
-0.0051242495,
-0.026109112,
-0.007920212,
-0.013162222,
0.0036472005,
-0.03009277,
0.022959867,
-0.012078829,
-0.017616922,
-0.0005938477,
-0.021075705,
0.056794047,
0.028370107,
0.0016915407,
-0.004811344,
0.007213651,
-0.0087344395,
0.030335018,
0.023861574,
-0.023255952,
0.013128577,
-0.000519827,
0.024965156,
-0.015840424,
0.03415718,
0.027777942,
0.005679405,
-0.019554917,
0.000916847,
-0.012072099,
-0.01897621,
-0.05127614,
-0.0032737327,
0.0028531607,
0.010524394,
0.009434272,
-0.0044042305,
0.0019379959,
-0.008472003,
-0.030442685,
0.021048788,
-0.017886087,
0.019420333,
-0.003590003,
-0.002434271,
0.014238887,
0.0041888976,
-0.020295125,
0.0029322281,
0.007099256,
-0.0045455424,
0.0037986066,
0.00021091687,
0.014185053,
0.0006089883,
-0.017334297,
-0.0060932473,
0.016997838,
-0.029635187,
-0.024467198,
-0.018074503,
-0.0037279504,
0.028881522,
-0.0114866635,
0.019958666,
-0.0070588808,
-0.0027589526,
-0.03453401,
0.008034608,
0.009151648,
-0.029366022,
-0.011378997,
-0.008626773,
0.008707523,
-0.0008171715,
0.00021701517,
-0.16946697,
-0.0044042305,
0.0320846,
-0.021667872,
0.0064768093,
0.018787794,
-0.00010077957,
0.0066786837,
-0.01698438,
-0.0039668353,
0.007765442,
0.007018506,
-0.02826244,
-0.0073549636,
0.031411685,
-0.014548427,
-0.026189862,
0.013121847,
0.02111608,
0.021237206,
0.01080029,
-0.050603226,
0.035045426,
-0.011789475,
0.0090708975,
0.0035462633,
0.014871427,
0.024547948,
0.01785917,
-0.046027403,
-0.03429176,
0.012173037,
0.016405674,
0.005729873,
-0.00045127378,
-0.0034991594,
-0.02357895,
0.010968518,
0.002568854,
0.020577747,
0.014386928,
0.027858691,
-0.0051578954,
0.026001446,
-0.013209326,
0.018707044,
0.011237685,
-0.013296805,
0.0119106,
0.011325164,
-0.0033376596,
-0.0069444855,
0.008768085,
0.022784911,
-0.00865369,
0.020308582,
0.0114866635,
0.00952848,
0.011681809,
-0.02072579,
-0.0018017306,
-0.040321082,
0.027051194,
-0.001885845,
-0.002632781,
-0.017320838,
-0.0006388489,
-0.004754146,
-0.032515265,
-0.0017007933,
0.0060932473,
0.010524394,
-0.007967317,
-0.013364097,
0.011681809,
0.012395099,
-0.022677245,
-0.013956262,
0.020927664,
0.009669792,
0.006194185,
0.027078109,
-0.030523436,
-0.024023075,
-0.015826967,
-0.015773132,
-0.002691661,
0.015625091,
-0.0152482595,
0.00012165046,
0.019501084,
-0.02952752,
-0.003515982,
0.012852681,
0.022771452,
0.022313869,
0.012502765,
-0.010497478,
-0.014400386,
-0.0108137475,
0.0311156,
0.011850038,
-0.016997838,
0.023807742,
0.030442685,
-0.0072876723,
-0.020402791,
-0.0087344395,
0.031761598,
-0.00977073,
-0.0013054556,
0.005699592,
0.030765684,
0.0026378278,
-0.009420813,
0.042689744,
0.009407355,
-0.013310264,
0.022354245,
-0.0012280704,
0.06809902,
0.014831052,
-0.0111502055,
-0.00012133503,
-0.03415718,
-0.011876954,
-0.14222737,
-0.030631103,
0.0072069224,
0.021291038,
-0.007213651,
-0.002318193,
-0.016930548,
0.0030432593,
-0.012132661,
0.047453985,
-0.015786592,
-0.032407597,
-0.0030987747,
0.0014459266,
0.02818169,
0.0099860625,
0.014871427,
-0.01651334,
-0.027616441,
0.030200437,
-0.029339105,
0.0061167995,
0.011567413,
-0.006571017,
-0.0023905314,
0.0046464796,
-0.012825765,
0.018599378,
-0.0036808464,
-0.00238212,
-0.008714252,
-0.02271762,
0.022111995,
0.012980535,
-0.016136508,
-0.012469119,
-0.0029238167,
-0.044116322,
0.025463114,
-0.011930787,
0.011163664,
0.025422739,
0.028720023,
0.019083876,
-0.002996155,
0.006254747,
-0.0009656334,
0.015773132,
-0.008862293,
-0.007920212,
-0.005578467,
-0.0314386,
-0.006557559,
-0.008714252,
0.02834319,
-0.000024169749,
0.021291038,
0.016688298,
-0.012563327,
0.018760877,
-0.020039417,
-0.002802692,
-0.041424662,
0.024130741,
0.008505649,
-0.011015623,
-0.035206925,
-0.031573184,
0.011654892,
0.0011532085,
-0.01730738,
0.018989667,
-0.014938719,
0.010288874,
-0.05819371,
-0.0022761358,
-0.0012465755,
-0.016230715,
0.017913004,
0.00083483546,
-0.01230762,
-0.027777942,
0.024494115,
-0.0152482595,
0.0047743334,
0.014400386,
0.023215575,
0.002557078,
-0.01396972,
-0.009508292,
-0.015167509,
0.020416249,
0.0038625335,
-0.02103533,
0.0051410724,
-0.015490509,
-0.0019312667,
0.011103102,
-0.016553715,
0.025866862,
0.002335016,
-0.009420813,
-0.037037253,
0.029823603,
0.018114878,
-0.0055246344,
0.016917089,
-0.006503726,
0.019635666,
0.0005967917,
-0.008404711,
0.010981977,
-0.018518627,
0.006335497,
0.009313147,
-0.011863496,
-0.045085322,
-0.022757994,
0.028989188,
-0.019070419,
0.022179287,
0.012980535,
-0.010349437,
0.012973806,
-0.008498919,
0.011520309,
-0.0056423945,
-0.021963954,
-0.009441001,
0.008546024,
-0.013229514,
0.014521511,
0.02048354,
-0.031465515,
-0.010214853,
0.019043501,
-0.022017786,
-0.020510457,
0.011446289,
0.031061769,
0.017603463,
0.04040183,
-0.028127857,
-0.013094931,
0.0051107914,
-0.01563855,
0.016082674,
0.0056390297,
-0.027064651,
-0.00888921,
0.0066315797,
-0.01023504,
0.007361693,
0.023013702,
0.0013878878,
-0.023336701,
-0.026889693,
0.0014963953,
0.008350878,
0.011136747,
-0.0011977891,
0.003187936,
0.016661381,
0.018141795,
0.025920695,
-0.026270611,
0.005302572,
0.00068385014,
-0.023000242,
-0.029554438,
-0.013525597,
-0.012872868,
-0.019864459,
-0.012287432,
0.007866379,
0.0131689515,
-0.009541938,
-0.009858209,
0.0095890425,
0.019016584,
-0.013754387,
0.009481376,
0.01659409,
-0.01810142,
-0.020860372,
0.021802453,
0.021412164,
0.004898823,
-0.039675083,
0.035045426,
-0.020308582,
0.014804135,
0.0094679175,
0.00021081173,
-0.007314589,
-0.00674934,
0.0031071862,
-0.009764,
-0.022973327,
-0.012603703,
0.005050229,
0.018464794,
-0.0071598184,
0.020968039,
0.006237924,
-0.035314593,
0.0026176404,
0.023484742,
-0.043685656,
-0.034668595,
-0.0004823961,
0.024103824,
0.034749344,
0.0027168952,
-0.0031627016,
-0.0051276144,
-0.02842394,
0.009629417,
-0.03666042,
0.0024645522,
-0.016109591,
-0.0049257395,
0.016149966,
-0.010194666,
0.00519827,
-0.0015191062,
0.01492526,
0.00045800293,
0.04325499,
-0.0022895942,
0.009319876,
0.0008823601,
0.025436196,
-0.013465034,
-0.03404951,
-0.014010095,
-0.020066332,
-0.043981742,
-0.0060831537,
-0.007630859,
-0.01476376,
0.072028846,
-0.014090845,
-0.0155847175,
0.010046625,
-0.006870465,
0.018680127,
-0.02247537,
0.014790677,
0.0014097574,
-0.034830093,
0.028370107,
-0.038383085,
0.020766165,
-0.02754915,
-0.003960106,
0.027831774,
0.0029927907,
0.022354245,
0.012139391,
-0.011338622,
0.022731077,
-0.01651334,
0.0012432109,
-0.004407595,
-0.022286953,
-0.027320359,
0.029258355,
0.010975247,
-0.013875512,
-0.025355447,
-0.0040072105,
-0.0057366025,
-0.030065853,
-0.0014762079,
0.0006674478,
-0.007886566,
-0.0073953387,
-0.039056,
-0.0027606348,
0.012314349,
-0.030308103,
0.013613075,
-0.019877916,
-0.009427543,
-0.019514542,
-0.004717136,
0.0023148283,
-0.0062513826,
-0.018397503
] |
Duplication and segregation of chromosomes involves dynamic reorganization of their internal structure by conserved architectural proteins, including the structural maintenance of chromosomes (SMC) complexes cohesin and condensin. Despite active investigation of the roles of these factors, a genome-wide view of dynamic chromosome architecture at both small and large scale during cell division is still missing. Here, we report the first comprehensive 4D analysis of the higher-order organization of the Saccharomyces cerevisiae genome throughout the cell cycle and investigate the roles of SMC complexes in controlling structural transitions. During replication, cohesion establishment promotes numerous long-range intra-chromosomal contacts and | [
-0.0016583378,
0.011287803,
0.00821849,
-0.026950724,
-0.024500659,
0.022858307,
-0.007410776,
0.012425334,
0.001211571,
-0.012862845,
0.013091698,
0.022077516,
0.027394967,
0.021350574,
0.003944337,
0.0050078267,
0.027946904,
-0.021862125,
-0.026789181,
-0.013502286,
-0.025752615,
-0.0044794474,
-0.008662732,
-0.033547055,
0.011247418,
0.013865757,
0.021162108,
-0.026856491,
-0.0054150494,
-0.0062665143,
0.004795802,
0.0068184524,
0.00077994884,
-0.018092794,
-0.031823933,
0.004287615,
0.01041951,
-0.009032935,
-0.0008859613,
-0.026829567,
0.009645452,
0.014175381,
-0.018012023,
0.012883038,
-0.005973718,
0.02190251,
-0.0117522385,
-0.017392775,
-0.0015388634,
0.0058189062,
0.007148269,
0.026291091,
-0.030881599,
0.0012384948,
-0.01635621,
-0.008723311,
-0.004826091,
0.017823556,
0.0036919261,
-0.01863127,
0.013758061,
-0.004916959,
-0.018658193,
0.019142821,
-0.0013638587,
-0.0036044237,
0.0130311195,
-0.014256152,
0.0070876903,
0.0011392133,
0.045097366,
0.027866133,
0.001076952,
-0.011880127,
0.003044072,
-0.036050968,
-0.027677666,
-0.0086963875,
-0.016531214,
0.011577234,
0.0063102655,
-0.014283076,
0.012708033,
0.026950724,
-0.000054899312,
0.01105222,
0.019142821,
-0.018940894,
0.0058054444,
0.0048058983,
0.023719868,
0.03448939,
0.02188905,
0.015063866,
-0.02622378,
0.0066232546,
-0.0033738888,
0.03010081,
-0.00007004395,
0.012862845,
-0.01338786,
0.008528113,
-0.020919792,
-0.019910151,
-0.02996619,
-0.026237244,
0.04200113,
0.001852694,
-0.001782019,
-0.015386952,
-0.010029116,
0.022064054,
-0.015548495,
-0.029939266,
0.024635278,
-0.020085154,
-0.0057684244,
-0.0072492333,
-0.0031298918,
-0.009537756,
0.01409461,
0.019196669,
0.012351293,
-0.032981656,
0.025375681,
-0.012903231,
-0.020287083,
0.006757874,
0.001102193,
-0.007027112,
0.020004384,
0.00963872,
0.013946529,
0.019371673,
-0.033250894,
-0.0064280573,
0.0031080162,
-0.00018983382,
-0.018227413,
-0.05037443,
0.008380033,
0.0365356,
-0.018012023,
-0.0117522385,
0.007902135,
0.013273434,
0.0137176765,
0.0074646235,
-0.0067814323,
0.015063866,
0.022131363,
-0.004738589,
0.002788296,
0.019587064,
0.019304365,
0.036508672,
-0.00403857,
0.00998873,
-0.010257968,
-0.014350385,
0.00026187603,
0.021310188,
0.014673471,
0.00033065793,
0.005135715,
0.024769897,
0.001884666,
-0.011785894,
0.0025527128,
-0.009477178,
-0.005778521,
0.0035101904,
-0.042674225,
0.02288523,
-0.028458457,
0.023154467,
-0.0033755715,
0.0038669307,
-0.03747793,
-0.022198673,
0.0070809596,
0.013657098,
0.036374055,
0.011644543,
-0.019587064,
-0.004102514,
0.009356021,
0.0019704856,
-0.0025291545,
-0.003883758,
-0.0024315557,
-0.009551218,
-0.0007828936,
-0.013044581,
-0.62850916,
0.0021118356,
0.019169746,
-0.03960491,
-0.009780071,
0.028539227,
0.011610889,
0.014848475,
-0.016921608,
0.0013857343,
0.0057684244,
0.017042765,
0.015319643,
-0.014336923,
-0.024392962,
-0.03890489,
0.015386952,
-0.012364755,
0.027394967,
0.010877215,
-0.014215766,
0.0012241915,
-0.0070809596,
0.011153184,
0.0040284735,
-0.01332055,
0.050562896,
-0.015440799,
0.001179599,
0.04143573,
-0.032470103,
-0.0062193978,
-0.024177572,
0.007181924,
0.04515121,
0.023356397,
-0.016558137,
0.013354205,
0.029939266,
0.03465093,
-0.012411872,
-0.012391679,
0.005583323,
0.011624351,
-0.01671968,
0.018160103,
0.014942709,
-0.019142821,
-0.003506825,
-0.0057717897,
0.0008102381,
-0.012862845,
-0.013455169,
0.01615428,
0.009315635,
0.008157912,
0.040574167,
-0.008662732,
0.010540668,
0.029454637,
0.0014824917,
0.015965814,
-0.018362032,
-0.017810093,
-0.01502348,
0.0067982594,
-0.01580427,
0.00091120234,
0.01941206,
0.011954167,
-0.0027041591,
0.020408241,
-0.0060006417,
-0.0071684616,
-0.010352201,
0.024487196,
0.00534774,
0.01701584,
0.0018442803,
0.01041278,
-0.008083871,
-0.011462808,
-0.010466628,
-0.033277817,
0.009147361,
-0.005445339,
-0.031043142,
0.009605066,
0.00003536378,
-0.018860122,
0.010614708,
-0.008305992,
0.015548495,
-0.023221778,
-0.025671843,
0.01821395,
-0.007713669,
0.012378217,
0.0047520506,
-0.045932002,
-0.00928198,
-0.00062387495,
-0.0126878405,
-0.008413687,
0.011590696,
0.016060047,
-0.02125634,
0.019910151,
0.0483013,
-0.0055664955,
0.005758328,
-0.009806994,
-0.019183207,
0.0015800905,
-0.011038758,
-0.027193038,
0.03661637,
0.02097364,
0.0031467192,
-0.026600715,
0.016060047,
-0.015521571,
-0.00037819525,
-0.01891397,
0.020260159,
0.007282888,
0.018887047,
-0.0069463407,
-0.0066569094,
-0.007262695,
0.016679294,
0.017190846,
0.018725503,
-0.024769897,
0.020798635,
0.016827375,
-0.007262695,
-0.01778317,
0.0036851952,
-0.035458643,
-0.01310516,
0.0064145955,
0.0010121666,
-0.0065862346,
-0.00417992,
-0.009652182,
-0.04620124,
-0.012008015,
0.0070809596,
-0.014956171,
-0.01480809,
0.02592762,
-0.015050405,
0.007107883,
-0.008023293,
-0.0069598025,
0.00063312997,
-0.028943086,
-0.016060047,
-0.02225252,
0.017163923,
-0.008386764,
-0.020085154,
-0.006172281,
-0.011186839,
-0.012815729,
-0.0007134807,
-0.016921608,
-0.006993457,
-0.03136623,
0.008804083,
-0.020919792,
-0.030908523,
0.0066064275,
0.0136234425,
0.018510113,
0.005455435,
-0.0042674225,
-0.0023036676,
-0.008528113,
0.010574322,
-0.017608166,
-0.01927744,
-0.01635621,
0.038581807,
0.010426242,
0.050051343,
-0.012916693,
0.012391679,
0.02245445,
-0.005250141,
0.006172281,
0.011651275,
-0.012923424,
0.013986914,
-0.003903951,
-0.015696576,
0.003796256,
0.0060006417,
0.030666208,
0.02075825,
-0.019115899,
-0.015494647,
-0.021848664,
0.022790996,
-0.027946904,
-0.0027092074,
-0.0077203996,
0.01984284,
0.014269614,
0.0053612017,
-0.01813318,
0.0006217715,
0.0054756277,
0.012593607,
0.009780071,
-0.00019740615,
0.0007664869,
-0.015481185,
0.013239779,
-0.007518471,
-0.02586031,
0.037666395,
-0.017042765,
0.006276611,
-0.0074915476,
-0.0009372848,
0.035808653,
-0.008211759,
-0.014283076,
-0.025052596,
0.03508171,
-0.009719492,
-0.0005822272,
0.023531402,
0.011489732,
0.023262164,
-0.0035472107,
0.024271807,
-0.002448383,
0.0015001604,
0.027731514,
0.008985818,
-0.012883038,
0.015050405,
-0.012176288,
0.019923612,
0.010237775,
0.007404045,
-0.0013293626,
-0.009557949,
-0.0042102095,
-0.01941206,
0.000641123,
0.0014118168,
-0.013421514,
0.009732954,
0.007807902,
0.04350886,
0.03422015,
-0.0132599715,
-0.023692945,
-0.0047789747,
-0.00751174,
-0.021673659,
-0.0004547598,
0.015158099,
-0.006088144,
-0.014013838,
0.0016709584,
-0.002539251,
0.023033312,
0.006596331,
-0.021215955,
0.0040553976,
0.0042102095,
-0.006242956,
0.010231044,
0.0051592733,
0.0010466627,
-0.016611984,
-0.031985473,
0.0032056149,
0.02223906,
-0.008265607,
0.009833918,
-0.019815916,
0.0056304396,
-0.010682018,
0.01509079,
-0.006993457,
0.011233956,
-0.023275625,
-0.00088427856,
-0.027098805,
-0.005172735,
0.017527394,
-0.0088310065,
0.008144449,
0.013959991,
0.01311189,
0.028350761,
0.0074713547,
-0.005425146,
0.04202805,
-0.0051592733,
0.007141538,
-0.016329285,
-0.014727319,
-0.025914157,
-0.012553222,
-0.020502474,
-0.014431157,
0.007000188,
0.0002193869,
-0.011738777,
-0.0053309123,
-0.009012742,
0.018833198,
0.0033217238,
-0.012008015,
-0.023221778,
-0.008205028,
-0.002333957,
0.046416633,
0.040789556,
-0.025092982,
0.010406049,
-0.0074780853,
0.01671968,
-0.0022868402,
-0.009275249,
0.010136811,
-0.025241062,
-0.014740781,
-0.023908334,
0.019169746,
0.002281792,
-0.0022615993,
0.025591072,
0.0014496783,
-0.010823368,
-0.008178105,
0.004334732,
0.000066678476,
-0.016450442,
0.033843216,
0.03782794,
0.021781355,
-0.00008787045,
0.005835734,
0.023275625,
-0.009773339,
-0.008400226,
-0.012391679,
0.017540855,
0.016046586,
0.029858494,
-0.016800452,
-0.025066057,
0.023639096,
0.0118666645,
-0.011967629,
0.026668023,
0.02210444,
0.006030931,
0.020233236,
0.010432973,
0.011772431,
-0.000056950146,
0.016410057,
0.018052408,
-0.015494647,
-0.01111953,
0.030800827,
-0.028781543,
0.003853469,
-0.0009313952,
0.018644731,
-0.020583246,
-0.0132599715,
-0.015831195,
0.002000775,
-0.016019661,
-0.02486413,
-0.02712573,
0.0013108525,
-0.0047352235,
-0.0088310065,
-0.0022329928,
-0.015225409,
-0.0025039134,
-0.030639285,
-0.018819736,
0.008205028,
-0.0358625,
-0.042216517,
-0.021767892,
0.029993113,
0.02280446,
0.02034093,
-0.01651775,
-0.018967817,
0.013448439,
-0.011267611,
-0.019640911,
-0.014888861,
-0.027569972,
-0.030477742,
0.010809906,
0.010803175,
-0.007828095,
-0.011254149,
0.008110795,
0.015319643,
-0.002244772,
0.01615428,
-0.016423518,
-0.0125734145,
0.0113887675,
0.01841588,
0.04313193,
0.006905955,
-0.019250518,
0.0008682926,
-0.038393337,
-0.013825371,
-0.015036942,
0.005132349,
-0.005186197,
-0.016544675,
0.0022548682,
-0.017890865,
0.0032476834,
-0.003493363,
-0.024352577,
0.0043751174,
-0.00084599626,
0.021714045,
0.025941081,
0.009389675,
0.0069328784,
-0.009793532,
-0.0082386825,
0.0019974094,
-0.024904516,
0.012283984,
0.00020497847,
-0.015911967,
0.02479682,
-0.01048682,
-0.027785363,
-0.016208127,
0.00421694,
0.0081242565,
0.042243443,
-0.010661825,
-0.03990107,
0.006064586,
-0.0046308935,
0.016086971,
0.013737869,
-0.003096237,
-0.0015817733,
-0.0010988276,
0.009941613,
0.0077405926,
-0.021700583,
-0.0145927,
-0.037720244,
-0.003251049,
0.00048841455,
0.017177384,
0.032173943,
0.012283984,
-0.007821364,
-0.0012132537,
-0.009389675,
-0.011765701,
-0.04455889,
0.0026637735,
-0.012458988,
0.04286269,
0.030531589,
0.05874773,
0.023962183,
0.010251237,
0.016383132,
0.024137188,
-0.017621627,
-0.008918509,
0.009443523,
-0.014175381,
0.03683176,
0.018442804,
0.021094797,
0.0013815275,
-0.018025484,
0.031150836,
0.039120283,
-0.005108791,
-0.0375587,
0.003173643,
-0.044316575,
-0.014390771,
0.004371752,
0.0034125918,
-0.023248702,
-0.021646736,
-0.0023945356,
0.003070996,
0.01962745,
0.0035741345,
-0.006185743,
0.03621251,
-0.0010315181,
0.037774093,
-0.000064522465,
0.0151311755,
-0.0116378125,
-0.008878123,
-0.024985287,
-0.0074780853,
0.02174097,
0.002281792,
0.03408553,
0.009813725,
-0.008305992,
-0.02132365,
0.009584873,
-0.033223968,
-0.017338928,
0.0046342593,
-0.029535409,
0.0021505386,
-0.015185024,
-0.0152657945,
-0.044262726,
0.009833918,
-0.0010340422,
-0.011806087,
0.018388955,
0.010318547,
-0.013239779,
0.024702586,
0.024527581,
0.012351293,
-0.021592887,
0.015521571,
-0.0062597836,
-0.004994365,
-0.02174097,
-0.0009381262,
-0.0061016064,
-0.0025947813,
0.037047148,
0.01947937,
-0.0131792,
-0.0046578175,
-0.0040924177,
-0.004741954,
-0.017635088,
-0.049701337,
-0.010311816,
0.014740781,
0.011355112,
0.009894497,
0.01580427,
-0.011873396,
-0.0038366416,
0.011691661,
0.0031584983,
0.014296538,
-0.007848288,
0.00047621471,
0.015979275,
-0.010560861,
0.009901227,
-0.004624163,
-0.025308372,
0.017756246,
-0.0034109089,
0.007929059,
-0.0016028074,
-0.009625259,
0.018954355,
0.008622347,
-0.014727319,
0.011058951,
0.028000752,
-0.025981467,
-0.022723688,
-0.024567967,
0.040762633,
-0.0033368685,
0.005744866,
-0.00068908103,
0.004620797,
0.0070540356,
0.0036650023,
0.002019285,
-0.009100244,
-0.036024045,
-0.00850792,
0.017473547,
0.011610889,
0.014888861,
-0.025348758,
-0.004031839,
0.013576326,
-0.01884666,
-0.012761882,
-0.002468576,
-0.042970385,
-0.0037794285,
0.00035716104,
0.014377309,
0.03591635,
-0.004109245,
-0.0027327656,
-0.020031307,
0.038447186,
-0.012075325,
0.01813318,
0.016665833,
-0.012492644,
-0.031823933,
0.026102625,
-0.019762069,
-0.02139096,
-0.010520475,
0.0023810735,
-0.0145927,
0.013838833,
0.009544487,
0.0140811475,
0.0020041403,
-0.01884666,
0.011859934,
-0.010459896,
0.01112626,
-0.008844469,
-0.020139003,
-0.003988088,
-0.045878157,
-0.007404045,
0.023585249,
-0.004519833,
-0.0008211759,
0.017379314,
-0.028727695,
0.013502286,
-0.014390771,
-0.0008640857,
0.0016835788,
-0.00492369,
0.0045770463,
0.013226317,
-0.005155908,
-0.021337112,
-0.0012957079,
0.008743504,
-0.01097818,
-0.00885793,
-0.007713669,
0.0025207407,
0.009827187,
0.004078956,
-0.022939079,
-0.00032666142,
-0.0015489599,
-0.025092982,
-0.04690126,
0.002724352,
-0.005095329,
0.027408428,
0.0038231795,
-0.00878389,
-0.013589788,
-0.012701303,
-0.03230856,
-0.031850856,
0.008938702,
-0.0060208347,
-0.00012305018,
0.024487196,
-0.020071693,
0.0035741345,
0.003256097,
0.020273622,
0.012216674,
-0.00538476,
0.020435164,
-0.011112799,
0.024891052,
0.00421694,
-0.020569783,
-0.003506825,
0.016086971,
-0.0008682926,
-0.0029700317,
0.007027112,
0.012667648,
0.014175381,
0.0052467757,
0.0068723,
-0.0034967286,
0.016423518,
0.02034093,
-0.02712573,
-0.0090598585,
0.0012368121,
-0.0053376434,
-0.02054286,
0.023612173,
-0.031420074,
-0.01791779,
0.01828126,
0.014350385,
-0.027246885,
0.011301265,
-0.026304552,
0.0086963875,
0.016329285,
0.016490828,
0.01933129,
0.0297508,
0.007000188,
0.0045400257,
-0.005852561,
-0.01884666,
-0.012277253,
-0.0054588006,
-0.016113894,
-0.0032813381,
-0.0066198893,
-0.008931971,
-0.00008487307,
0.0029010396,
-0.006404499,
-0.012936886,
-0.03817795,
0.026156472,
-0.0059972764,
0.012075325,
-0.027018033,
-0.016733142,
-0.027946904,
-0.0080098305,
0.031150836,
-0.003826545,
-0.020287083,
0.02826999,
-0.0036347131,
-0.04060109,
0.005859292,
-0.01743316,
0.0070809596,
-0.008312724,
0.009275249,
0.19460523,
-0.00031530295,
-0.00949064,
0.031797007,
-0.009981999,
-0.016840838,
0.0112003,
-0.00042215677,
-0.0015523253,
0.011058951,
0.015508109,
-0.00043582902,
-0.013838833,
-0.0034210053,
0.026614176,
-0.001820722,
-0.020112079,
0.0012830873,
-0.02627763,
0.009147361,
0.012485912,
-0.021471731,
-0.008763697,
0.012028208,
0.014498467,
-0.027381504,
-0.022925615,
-0.0052164863,
-0.020031307,
0.02288523,
-0.030773904,
0.0072088474,
-0.008622347,
-0.0058256374,
-0.00012094676,
-0.00341764,
0.014929247,
-0.008400226,
-0.009046397,
-0.00210847,
-0.015185024,
-0.012230136,
0.008777159,
-0.002352467,
0.0049842685,
-0.011106067,
-0.009793532,
-0.0025089616,
0.0015472771,
-0.0115031935,
-0.046147395,
0.014929247,
0.003397447,
0.049109012,
-0.008110795,
-0.018954355,
-0.010385856,
0.0029582526,
0.0062328596,
0.015615804,
-0.0348394,
0.0013781621,
-0.017823556,
0.002576271,
-0.0038736619,
0.01706969,
-0.017702399,
0.0140811475,
0.032227788,
-0.03661637,
0.0060814135,
0.003564038,
-0.02707188,
-0.027569972,
0.003846738,
0.009160823,
0.06079394,
-0.0015624218,
0.041974206,
0.018550498,
-0.015750423,
-0.004647721,
-0.03209317,
0.009275249,
0.026668023,
-0.016329285,
0.038797196,
-0.012088786,
-0.015440799,
-0.019169746,
-0.0059838146,
-0.0056943838,
0.0035573072,
-0.019735146,
0.014727319,
0.0137446,
-0.0035573072,
0.018119717,
-0.0029145014,
0.0007711145,
-0.031797007,
0.062570915,
0.030450817,
0.0022515028,
0.0065492145,
-0.012088786,
0.006808356,
-0.009524294,
-0.00092550565,
-0.02423142,
0.013986914,
-0.030585436,
0.0033957644,
-0.013401321,
-0.005135715,
0.014969633,
0.027704591,
-0.057509236,
0.05285142,
-0.0065694074,
-0.0032544143,
-0.026371863,
0.0064011337,
0.019802455,
-0.0047924365,
-0.002539251,
-0.0108166365,
0.0021337112,
-0.015171561,
-0.03343936,
0.016100433,
-0.001644876,
0.0016280485,
0.0039544334,
0.0036818297,
-0.015750423,
0.013118622,
-0.0030676306,
-0.0000582122,
-0.008985818,
-0.00835984,
-0.002897674,
0.01743316,
0.010035846,
-0.0122099435,
-0.0042034783,
0.014121533,
0.028862314,
-0.029723875,
-0.0291854,
-0.0033065793,
-0.009557949,
0.0030423894,
-0.021983283,
0.001955341,
-0.02032747,
0.0012654186,
-0.042674225,
-0.021000564,
0.008837737,
-0.023571787,
0.022023669,
0.013919605,
0.019883227,
-0.013421514,
0.0021589522,
-0.16983533,
0.010466628,
0.010917601,
-0.020139003,
-0.00156747,
0.016329285,
0.011954167,
0.040978026,
0.008514652,
0.015898503,
-0.0037255809,
0.008918509,
-0.03330474,
-0.011765701,
-0.002583002,
0.014579237,
-0.0010424559,
0.008420419,
0.008070409,
-0.004115976,
0.0088310065,
-0.03591635,
-0.00400155,
-0.014256152,
-0.005872754,
0.015225409,
-0.011799355,
0.0026065605,
-0.029320018,
-0.0260757,
-0.0019250517,
0.005953525,
0.034273997,
-0.014458081,
-0.015292718,
0.0034967286,
-0.021121722,
0.005896312,
-0.007915597,
0.008979088,
0.035593264,
0.017379314,
0.00815118,
-0.0073098117,
0.008790621,
0.0375587,
-0.010621439,
-0.012122441,
0.03209317,
0.0040890523,
0.005233314,
-0.0080098305,
0.015386952,
0.022050593,
0.019263979,
0.0037794285,
-0.0007488182,
0.029158475,
-0.0020563053,
-0.0034529774,
-0.016706217,
-0.019385137,
0.042835765,
-0.012943617,
-0.004546757,
-0.024541045,
-0.015602342,
0.014363848,
-0.033627827,
0.025416067,
0.007861749,
0.016060047,
-0.0040082806,
-0.01147627,
0.01041951,
0.015158099,
-0.0046376246,
0.0016894685,
-0.007888674,
-0.02471605,
-0.012458988,
0.017729321,
-0.0144446185,
-0.03403168,
-0.0012014746,
-0.0054756277,
-0.008770428,
0.012519567,
-0.0064886357,
0.026694948,
0.010655094,
-0.026156472,
0.008844469,
-0.002333957,
0.032523952,
0.0102243135,
-0.019560141,
-0.01828126,
-0.012492644,
-0.021000564,
0.007666552,
-0.0062799766,
-0.02458143,
0.007908867,
0.02345063,
0.013132083,
0.0041496307,
0.011011834,
0.05220525,
-0.020112079,
-0.017136998,
-0.025968006,
0.019385137,
0.024069877,
0.007955983,
0.026748795,
0.000110429646,
0.009389675,
-0.01197436,
0.0073703905,
0.07334043,
-0.0027613724,
-0.01785048,
-0.0001673272,
0.018967817,
0.013758061,
-0.12891115,
-0.0057515968,
-0.025900695,
0.051666774,
0.000016393544,
0.016558137,
-0.016275438,
0.02423142,
-0.007316543,
0.019237055,
-0.015723499,
-0.0066569094,
0.00371885,
-0.0034344674,
-0.011859934,
-0.0038972201,
-0.004156362,
-0.023437168,
0.001458092,
0.021633273,
-0.010372394,
0.0009987047,
-0.0051761004,
-0.025456453,
0.018887047,
0.0033452823,
-0.022373678,
0.029939266,
0.019115899,
0.024339115,
-0.008016561,
-0.013421514,
0.00701365,
0.0004736906,
-0.01211571,
-0.03422015,
0.00058811676,
-0.048570536,
0.036885608,
-0.0069396095,
0.0036111546,
-0.0013293626,
0.020112079,
-0.0064650774,
0.009840649,
-0.010984911,
-0.0022851576,
0.02444681,
-0.00055151724,
0.0018476457,
-0.0040486665,
0.0007399838,
-0.012559953,
-0.02316793,
-0.001638145,
-0.013482093,
0.026035314,
-0.008312724,
-0.0147677045,
0.0036683679,
0.0029582526,
0.019317826,
0.0008005624,
0.009113707,
0.027085343,
-0.030370047,
-0.023625635,
-0.028539227,
0.033950914,
-0.03718177,
-0.0024315557,
0.004526564,
-0.03973953,
-0.0013049629,
-0.020112079,
-0.0081242565,
-0.04200113,
-0.019290904,
0.016073508,
-0.020314008,
-0.0060544894,
-0.033547055,
0.030720055,
-0.0358625,
0.04407426,
0.0011518338,
0.0057145767,
-0.0023003023,
0.019304365,
0.0013781621,
0.014377309,
0.0269238,
0.0019654373,
-0.022319831,
-0.015992736,
0.006438154,
-0.023504477,
-0.008494459,
0.00598718,
0.014431157,
-0.03747793,
0.0034899977,
-0.057563085,
0.02174097,
0.005711211,
0.0035875964,
0.007666552,
-0.011624351,
0.0069396095,
-0.0120955175,
-0.0023423706,
0.031500846,
-0.027381504,
0.01190032,
0.00075050094,
-0.013697484,
-0.043185774,
-0.015844656,
0.028970009,
-0.0044323304,
0.022575606,
0.043347318,
-0.010385856,
-0.0010172148,
0.014888861,
0.039577987,
-0.026008392,
0.0042203055,
-0.00407559,
0.01906205,
-0.0144446185,
0.016383132,
-0.003917413,
-0.019963998,
-0.017837018,
0.0148754,
-0.0043751174,
-0.009234863,
-0.020623632,
0.014848475,
0.019465908,
0.020206312,
-0.009120437,
-0.030585436,
-0.010527206,
0.026021853,
-0.0038938546,
0.016975457,
-0.03521633,
0.009645452,
0.013360936,
-0.022575606,
0.01933129,
-0.0043953103,
0.021054411,
-0.03295473,
-0.008117526,
-0.008723311,
-0.00051113154,
0.0013133766,
0.015427338,
-0.047089726,
0.003237587,
0.024837205,
0.025496839,
-0.0009919738,
0.013973452,
-0.014215766,
-0.019088974,
-0.00014355854,
-0.009006011,
-0.026116086,
-0.009342559,
0.027408428,
0.011422422,
0.00094569847,
-0.031016218,
0.0010003875,
-0.022131363,
0.011880127,
-0.012795536,
0.017487008,
0.0006869776,
0.0034327845,
0.004428965,
0.021633273,
0.039766453,
-0.0044255997,
-0.00481936,
0.0403857,
0.0030036864,
0.010157004,
-0.0077540544,
0.025281448,
0.010150272,
-0.011684929,
0.010035846,
0.025698768,
-0.011260879,
0.009820456,
0.015211947,
-0.00023621428,
-0.010035846,
0.0036515405,
-0.018806275,
-0.014390771,
-0.007047305,
0.014431157,
-0.0009717809,
-0.031204684,
0.006609793,
0.0062934384,
0.01034547,
0.003424371,
0.01813318,
-0.0054655313,
0.011085874,
0.013071505,
0.008979088,
-0.011139723,
-0.00928198,
0.03096237,
0.014660009,
0.022265982,
0.0022918885,
0.013367667,
0.035593264,
0.009672375,
0.014040762,
-0.030450817,
0.0075992425,
-0.0034529774,
0.044047337,
0.0030794097,
-0.028000752,
-0.015898503,
-0.02818922,
0.0041058795,
0.009456985,
0.003981357,
-0.012930155,
0.077379,
0.02083902,
-0.011132991,
0.012344562,
-0.020906331,
0.026560329,
0.013986914,
-0.0058424645,
-0.003641444,
-0.039227977,
0.022696763,
-0.010157004,
0.005879485,
-0.020448627,
0.01105222,
0.019183207,
-0.010352201,
0.003372206,
-0.012371486,
-0.020462088,
-0.008198298,
-0.024971824,
0.008245414,
0.024204496,
-0.010116618,
-0.018146642,
0.026843028,
0.006323728,
-0.0017483643,
-0.004762147,
-0.007107883,
-0.017648552,
-0.03209317,
-0.009497371,
-0.016786989,
0.025442991,
0.017298542,
-0.009376213,
0.016935071,
0.015333104,
-0.008036754,
-0.010116618,
0.0042034783,
-0.014471543,
-0.0082386825,
0.002301985,
0.010682018,
-0.0066468134,
-0.0042842496
] |
The Heliconius butterflies are a diverse recent radiation comprising multiple levels of divergence with ongoing gene flow between species. The recently sequenced genome of Heliconius melpomene allowed us to investigate the genomic evolution of this group using dense RAD marker sequencing. Phylogenetic analysis of 54 individuals robustly supported reciprocal monophyly of H. melpomene and Heliconius cydno and refuted previous phylogenetic hypotheses that H. melpomene may be paraphylectic with respect to H. cydno. Heliconius timareta also formed a monophyletic clade closely related but | [
-0.028878713,
-0.015118073,
-0.01739377,
-0.023315901,
-0.010633222,
0.023635298,
-0.010233977,
0.012157007,
-0.026536476,
-0.033962432,
-0.0045347563,
0.011105662,
-0.0143462,
-0.028772248,
0.0023372462,
0.02882548,
0.02499273,
-0.007771967,
0.013248276,
-0.020454647,
-0.017806321,
0.005319938,
-0.0024803088,
-0.01710099,
-0.009907927,
0.025006037,
0.009129399,
-0.036996692,
-0.01105243,
0.0042153606,
0.008863237,
0.023262668,
-0.009714959,
-0.006624138,
-0.017699856,
-0.013720716,
0.02644332,
-0.020148559,
0.009927889,
-0.013241622,
0.011305285,
-0.003593204,
-0.006783836,
-0.0011378479,
-0.045513917,
-0.0047011087,
-0.001245145,
-0.003919254,
0.009062859,
0.014279659,
0.024141008,
-0.008676922,
-0.01426635,
0.0037628831,
0.012995421,
0.0115115605,
0.020068709,
0.0010521766,
0.004012411,
-0.012676025,
-0.009428834,
0.009714959,
-0.0042852284,
-0.0027581167,
-0.0021592495,
-0.018857667,
-0.0011187175,
-0.0075457282,
0.015677016,
-0.0061117737,
0.04383709,
0.02672279,
0.0040357006,
-0.012642755,
0.0032804622,
-0.02223794,
-0.00089913275,
-0.016116185,
-0.026988955,
0.008357527,
0.020201791,
-0.013600943,
0.0036264744,
0.0008063915,
0.0065243267,
0.0023023123,
-0.02839962,
-0.0087301545,
-0.000113327325,
-0.0031540345,
0.029011795,
0.02911826,
0.007099905,
0.008483954,
-0.01491845,
-0.0043750587,
0.006953515,
0.012030579,
-0.020813966,
-0.026097307,
-0.008883199,
-0.007984898,
-0.006434497,
-0.009136054,
-0.012296743,
-0.0067505655,
0.009834732,
-0.01672836,
0.022011701,
-0.032312218,
-0.030688623,
0.039525244,
-0.0084772995,
-0.033509955,
0.016621895,
-0.015437469,
0.0153443115,
0.030954788,
0.0062515093,
-0.020627653,
0.019469842,
0.0031257547,
-0.0028180035,
-0.03297763,
0.018125718,
0.024872957,
-0.007592307,
-0.015850022,
-0.0134279365,
0.013268238,
0.002535205,
-0.013341433,
0.026350163,
0.024473712,
-0.0075457282,
-0.0017067719,
-0.010899385,
-0.0032305566,
0.0032970973,
-0.027787443,
-0.013081924,
0.037555635,
-0.017273996,
0.011611372,
0.0025169062,
0.01752685,
0.018564887,
0.004112222,
-0.0021426142,
-0.019696081,
0.015464085,
0.0009939534,
0.018085793,
-0.0046378947,
0.020348182,
0.0057125287,
-0.019110521,
0.0010571672,
-0.025019346,
-0.01600972,
-0.011405095,
-0.009448796,
0.029304575,
-0.009102783,
0.01046687,
0.024247473,
0.0070932508,
-0.010806228,
0.003952524,
-0.011212127,
-0.031833127,
0.02274365,
-0.022051627,
0.013081924,
-0.01470552,
0.0084772995,
0.0039857947,
0.01840519,
0.020321565,
-0.024899572,
-0.034122128,
-0.0052068187,
0.010493486,
0.004265266,
-0.009861349,
-0.010806228,
0.023861537,
-0.012150353,
0.033057477,
-0.0120172715,
-0.006797144,
0.014279659,
-0.011045775,
0.0039026188,
-0.63070047,
-0.013773949,
0.016329115,
-0.030475693,
0.0021625764,
-0.00272651,
-0.002944431,
-0.016196035,
-0.0065975217,
0.00074858416,
-0.005549504,
0.0051103346,
0.01731392,
0.0035532794,
-0.041202072,
-0.039977722,
0.0019263566,
-0.02362199,
0.006045233,
-0.009002972,
-0.038327508,
-0.008444029,
0.01358098,
0.023382442,
-0.0005759939,
-0.00865696,
0.024367247,
-0.0014040112,
0.005146932,
0.02072081,
-0.02455356,
0.017912786,
-0.020561112,
-0.014652288,
0.04367739,
0.0016784921,
-0.0011469973,
0.022477487,
0.016023029,
-0.00008140853,
-0.012343321,
0.0019330106,
0.019004056,
0.0087301545,
-0.005283341,
0.016834825,
0.012117082,
-0.0095951855,
0.024793107,
0.0048408443,
0.017859554,
0.009655072,
0.0057358183,
0.0029960002,
-0.011025813,
0.00071572966,
0.036916845,
-0.017766397,
-0.032152522,
0.011245398,
-0.014532514,
-0.0023638625,
-0.017593391,
-0.0073461058,
-0.0038127888,
-0.009794808,
-0.015663708,
-0.017846247,
0.0012093793,
-0.026469937,
0.042852286,
-0.0017009496,
0.0016028018,
0.0016876414,
0.005343227,
0.047643222,
0.025152428,
-0.0031789874,
-0.0042153606,
0.048787724,
0.02158584,
-0.012349975,
-0.00095901947,
0.0047044354,
0.0389663,
-0.012403208,
-0.008543841,
0.029304575,
-0.0014730473,
-0.0077054263,
0.033217173,
-0.0003665983,
-0.016621895,
-0.016754977,
-0.0070533263,
0.0051802024,
-0.02652317,
0.0063546477,
0.01739377,
-0.03484077,
0.008736809,
-0.016581971,
0.012722604,
-0.022677109,
0.010746341,
-0.002067756,
-0.02028164,
0.0042619393,
0.03404228,
0.00036909358,
-0.013188389,
0.002132633,
0.0038859835,
-0.0017666586,
-0.004078952,
-0.036331285,
0.02551175,
0.028080223,
-0.0107330335,
-0.034361675,
0.0067372574,
0.009741575,
0.007073289,
-0.011025813,
0.003999103,
0.013667483,
0.003183978,
-0.049559597,
-0.0028778901,
-0.0044815238,
0.024500327,
0.004158801,
0.02471326,
-0.010001085,
0.009315714,
0.0121636605,
0.030076448,
0.0011569784,
0.03297763,
-0.02882548,
-0.021998392,
0.00655427,
0.0026449973,
-0.021825386,
-0.001755014,
-0.02000217,
-0.01941661,
0.0035798957,
-0.010999196,
-0.027787443,
0.013414628,
0.0007302854,
-0.0038760025,
0.014958375,
0.022703726,
0.011079046,
-0.008144596,
-0.006687352,
-0.017872863,
-0.021199904,
0.018139025,
0.006797144,
-0.033696268,
0.005789051,
-0.005732491,
-0.020627653,
-0.0089830095,
0.0062515093,
0.002896189,
-0.038593672,
-0.020907125,
-0.027707595,
-0.023089662,
0.018791126,
0.005040467,
0.009475412,
-0.008304293,
0.0063912454,
-0.011944076,
-0.004677819,
-0.0038793294,
-0.0014331228,
-0.006121755,
-0.025099196,
0.02701557,
-0.016688436,
0.025045963,
0.01521123,
0.02057442,
0.041681167,
-0.0010862788,
0.0029643932,
-0.005379825,
0.014612363,
-0.0035566066,
-0.038700137,
0.029544123,
0.015650399,
0.008197828,
0.037848417,
0.025085887,
-0.0078251995,
0.0077453507,
-0.0267361,
0.014372816,
-0.031487115,
-0.00952199,
-0.0045314296,
-0.003318723,
0.020760734,
0.014612363,
-0.018152334,
-0.0075390744,
-0.00432848,
0.02802699,
-0.0004408329,
0.005233435,
0.011584756,
0.032551765,
0.0018132372,
-0.0025668119,
0.0055029253,
0.0045979703,
0.015517318,
-0.0019496458,
0.0041887444,
0.017939404,
0.007439263,
-0.004268593,
0.011291976,
0.018791126,
0.019762622,
-0.004082279,
0.014772061,
0.036038507,
0.018152334,
0.015184614,
-0.0063978992,
0.013893722,
-0.004558046,
0.0059454218,
-0.0038626944,
-0.0005057102,
-0.009568569,
0.018857667,
0.021625765,
0.015743557,
-0.0029943367,
-0.00036098392,
-0.0039059457,
0.0011004187,
-0.017620008,
-0.00093905727,
0.008098017,
0.02629693,
-0.03265823,
0.0098480405,
0.012582868,
0.035373095,
0.011418404,
0.014066728,
-0.015730249,
-0.0051668943,
-0.023209436,
0.023888152,
-0.0069335527,
0.0073993388,
0.0015828396,
-0.010406983,
-0.0035832229,
-0.016036335,
-0.009921235,
0.010746341,
-0.01984247,
0.028745633,
-0.0081845205,
-0.013840489,
0.012729257,
-0.008164558,
0.016062953,
-0.03694346,
-0.05224785,
0.034015663,
0.017486926,
-0.02463341,
-0.04599301,
-0.029251343,
0.023568757,
-0.012057195,
0.025684755,
0.027055494,
0.007366068,
0.00022041645,
0.020907125,
0.012416516,
-0.022211324,
0.008843274,
-0.019802546,
0.028585933,
0.003228893,
-0.013434591,
0.006208258,
-0.008503916,
-0.0071997163,
0.04918697,
0.008756771,
0.0011769406,
-0.013946955,
-0.011331901,
-0.00014566201,
-0.0051802024,
-0.019576307,
-0.0064877295,
-0.018165642,
-0.013747333,
0.007871779,
-0.018045869,
0.0071597914,
0.007978244,
0.0042153606,
-0.039072767,
-0.021678997,
-0.032551765,
0.015118073,
0.04963945,
0.028559318,
-0.010579989,
0.00059595617,
0.011458328,
0.00075523823,
-0.013268238,
-0.0031856415,
0.0055960827,
-0.009754883,
-0.004751014,
0.019083906,
0.0123965535,
0.014505898,
-0.0057025477,
0.014905143,
-0.015823405,
-0.007818546,
-0.0031174372,
0.0052733594,
-0.020015476,
-0.012077157,
0.0215193,
0.016555354,
0.012735912,
0.0012010616,
0.03774195,
0.014013495,
-0.0011187175,
-0.027108727,
-0.008284331,
-0.010134166,
-0.015331004,
0.033935815,
-0.015331004,
-0.01376064,
0.01144502,
0.017340537,
0.011431712,
-0.03694346,
0.022477487,
0.0029111607,
0.021066822,
0.0040490087,
-0.011538177,
0.0038660213,
-0.00043376294,
0.0155971665,
-0.024034543,
-0.008810004,
0.029384423,
-0.0311411,
-0.0050604288,
-0.020853892,
0.0073793763,
-0.0044682156,
-0.007738697,
-0.0075856526,
-0.022557337,
0.029650588,
0.0070932508,
-0.025591597,
0.022011701,
-0.016528739,
-0.017460309,
-0.001879778,
-0.008424067,
-0.014891834,
-0.04149485,
-0.015397544,
0.008404105,
-0.020175176,
0.0044415994,
-0.0014638979,
0.022770267,
0.034068897,
0.015437469,
-0.02491288,
0.02962397,
0.032258987,
0.016475506,
-0.009535299,
0.012582868,
-0.029677203,
-0.0059886733,
0.027627746,
0.010313827,
-0.00040881013,
-0.018711276,
0.008723501,
-0.00815125,
-0.01159141,
0.007898395,
-0.00049988786,
-0.011844265,
0.03840736,
0.010473524,
0.024793107,
-0.007020056,
-0.008916469,
0.021998392,
-0.026336854,
-0.027441433,
-0.002115998,
-0.0035333172,
0.0052533974,
-0.010154128,
0.022158092,
-0.011278668,
-0.012416516,
0.002097699,
-0.0062515093,
-0.01307527,
0.008623689,
0.010047663,
0.0015312704,
-0.023928076,
0.0029743745,
-0.024872957,
-0.023209436,
0.014505898,
-0.008157904,
0.01869797,
0.0070533263,
-0.026283622,
0.030049833,
-0.005472982,
-0.017460309,
-0.016249267,
-0.016408965,
0.0039758137,
0.041388385,
0.01550401,
-0.03303086,
-0.0020344853,
0.0067505655,
-0.012216894,
0.021692306,
-0.026044074,
-0.017566776,
-0.019137139,
0.0136807915,
0.009249173,
-0.0075457282,
-0.0023854882,
-0.036570832,
-0.017593391,
0.020175176,
0.011464982,
0.0113651715,
-0.013334779,
-0.009828079,
0.0023006487,
-0.01307527,
0.025737988,
-0.0014697203,
0.004155474,
-0.001488019,
0.030848322,
0.028160073,
0.010892731,
-0.0023605353,
0.024833033,
0.022544028,
0.0019180389,
0.004401675,
-0.013853798,
0.010726379,
-0.018791126,
0.011451675,
-0.005622699,
0.01325493,
-0.02050788,
-0.015397544,
0.01242317,
0.03223237,
-0.019589616,
-0.020241715,
-0.005017177,
-0.04942652,
-0.018551579,
-0.0113851335,
-0.005655969,
-0.016581971,
-0.034068897,
-0.021958468,
0.029277958,
-0.0013524421,
0.0084772995,
0.0056992206,
0.045726847,
0.010021047,
0.054510236,
-0.018085793,
0.026842564,
-0.030449077,
-0.007831854,
-0.022677109,
-0.019523075,
0.024473712,
-0.014572439,
0.025378667,
-0.014865218,
-0.012855685,
0.0028862078,
0.016688436,
0.0049506365,
0.013507785,
-0.010746341,
0.002684922,
0.0056759315,
-0.004644549,
-0.020481262,
-0.013135157,
-0.011970692,
0.000099031444,
-0.010021047,
0.022756958,
-0.016036335,
-0.012316705,
0.017753089,
0.016981216,
0.030874938,
0.0009531972,
0.03744917,
0.018631428,
-0.0241277,
-0.038114578,
-0.0012992094,
-0.0046012974,
0.0036597447,
0.035027083,
0.036038507,
0.0006142549,
-0.006481075,
0.009129399,
0.005802359,
-0.01781963,
-0.02810684,
0.00021033136,
0.00019359218,
0.014040112,
-0.0057724155,
-0.005948749,
0.010892731,
0.0076122694,
-0.016848134,
0.030049833,
-0.011538177,
-0.03340349,
-0.009468758,
0.02072081,
-0.016967908,
0.023582065,
-0.01491845,
-0.023289286,
-0.010214015,
-0.00880335,
-0.029464273,
-0.007040018,
-0.014958375,
0.031779893,
-0.026669558,
-0.00076106057,
0.0077120806,
-0.020853892,
-0.009741575,
-0.023488907,
-0.020467954,
0.03092817,
-0.029091643,
0.006710641,
-0.00021272266,
0.000589718,
0.026163848,
0.002195847,
-0.005865573,
-0.0054130955,
-0.0022141456,
-0.0036198203,
0.019616231,
0.002982692,
0.021332985,
-0.0015936525,
-0.021825386,
-0.009575224,
-0.033882584,
-0.009608493,
-0.003267154,
-0.043863706,
0.009096129,
-0.009548607,
0.011039121,
0.0402705,
0.02512581,
0.0034967198,
-0.0111322785,
0.026177157,
0.00077187346,
0.024274088,
0.009581877,
0.0055428497,
-0.027867293,
-0.003139063,
-0.0079516275,
-0.030262763,
0.011252052,
-0.01170453,
-0.014625671,
0.011345209,
-0.0021908563,
0.007272911,
0.0037196316,
-0.023475599,
0.009136054,
0.0019446553,
0.0064378236,
-0.031327415,
-0.025085887,
0.033483338,
-0.024300706,
0.0005992832,
0.009482066,
0.0020378125,
-0.0060884845,
-0.020614345,
-0.006451132,
-0.0016028018,
-0.012789144,
-0.010347096,
-0.015490701,
0.006451132,
0.016794901,
0.0033636382,
-0.01680821,
-0.0061117737,
-0.0075257663,
0.003337022,
0.0051901834,
-0.0007269584,
-0.018298725,
0.034973852,
0.008716847,
0.024380554,
-0.010839499,
-0.020893816,
0.0048308633,
-0.017180838,
-0.05802359,
-0.013640867,
-0.006128409,
0.04490174,
0.0054097683,
-0.00039758137,
-0.034734305,
-0.012616138,
-0.03707654,
-0.04122869,
0.008111325,
0.016621895,
0.015730249,
0.0311411,
0.0029710473,
0.0052633784,
0.014572439,
0.032152522,
-0.0111322785,
-0.022464179,
0.022929965,
0.0034018992,
0.0074658794,
0.008191174,
-0.038274277,
0.0079516275,
0.023475599,
-0.013128502,
-0.03665068,
0.031912975,
-0.026469937,
0.0058323024,
-0.0071464833,
0.002545186,
0.013654175,
0.017074373,
0.01579679,
-0.033137325,
-0.024726566,
-0.0045879893,
-0.031034635,
-0.026549784,
-0.0069069364,
-0.0074725333,
-0.008883199,
0.029357808,
-0.044076636,
-0.033350255,
0.0134079745,
-0.0019413283,
0.009921235,
0.019310145,
0.004724398,
0.030023215,
0.004305191,
-0.021758847,
-0.02773421,
-0.016023029,
-0.00767881,
-0.023781687,
0.017260687,
-0.022517411,
-0.0016402311,
-0.030768473,
0.016129494,
-0.031354032,
0.00041109746,
-0.029011795,
-0.016102877,
-0.030555543,
0.018764509,
0.017473618,
-0.01064653,
-0.006940207,
0.012609485,
0.0026283623,
-0.010200707,
0.003925908,
0.008557148,
-0.005878881,
0.039498627,
0.014000188,
-0.017659932,
-0.006537635,
-0.0016768285,
0.0028462834,
-0.022770267,
0.0002518154,
0.19334099,
-0.035506178,
0.0045879893,
0.025964227,
-0.006357975,
-0.024779798,
0.0038760025,
0.00002059906,
-0.00628478,
0.015850022,
0.013414628,
-0.008470646,
0.0048075737,
0.0176067,
0.027760828,
-0.008696885,
-0.002007869,
-0.0067306035,
-0.019296836,
-0.021026898,
0.0008188679,
-0.0021842022,
0.014319583,
-0.009655072,
0.036198203,
0.00078019104,
-0.030795088,
-0.013827181,
-0.008124634,
0.020760734,
-0.036783762,
-0.014080036,
-0.0108794235,
0.012496365,
0.008770079,
0.0070666345,
0.0036530907,
0.002889535,
0.017473618,
0.0033353583,
-0.022344405,
0.002448702,
0.020960357,
-0.012170315,
0.015557243,
-0.0017916114,
-0.0036930153,
0.00530663,
-0.030741856,
-0.016874751,
-0.027547898,
0.026922414,
0.0026433337,
0.0080780545,
-0.007046672,
0.0064278427,
0.012416516,
-0.003992449,
-0.018897591,
0.028452853,
-0.021705614,
0.010100896,
0.0036098391,
0.0036564178,
-0.0058489377,
0.0077453507,
-0.01811241,
0.01097258,
0.00996116,
-0.018152334,
0.014226426,
-0.041202072,
-0.029437656,
0.0046345675,
0.0028180035,
-0.019429918,
0.019855779,
0.014292967,
0.013654175,
0.00865696,
0.024141008,
0.009648418,
-0.024606792,
0.013128502,
0.013827181,
-0.019549692,
0.033802733,
0.0076388856,
-0.021758847,
-0.017566776,
-0.002122652,
-0.003398572,
-0.0020927086,
0.014479281,
0.027215194,
-0.0029327865,
-0.0027414816,
-0.0053598625,
-0.02093374,
-0.026203772,
-0.016102877,
0.020986972,
0.01014082,
-0.0012501356,
-0.0037861723,
-0.0075590364,
-0.008563803,
-0.0007440095,
0.0298369,
-0.037715334,
0.009967814,
-0.022996506,
0.03151373,
-0.016036335,
-0.0026067365,
0.022064934,
0.00516024,
-0.035399713,
0.0024952805,
0.021718921,
-0.00465453,
-0.021000281,
0.0010363732,
0.030049833,
-0.021199904,
-0.012955497,
0.0022224633,
0.0059554027,
0.0032455283,
-0.0033719558,
0.016648512,
-0.030289378,
0.016382348,
0.004015738,
0.0007431777,
-0.00673393,
-0.0036098391,
-0.010080934,
-0.018511655,
-0.017367152,
-0.020601036,
0.009282444,
0.0049972152,
0.004511467,
-0.0052800137,
-0.01129863,
0.004072298,
0.018099101,
-0.015969796,
-0.0042053796,
-0.008104671,
0.0013258257,
0.00661083,
0.008570457,
0.024220856,
-0.033350255,
-0.004667838,
-0.030103065,
0.0054463656,
0.007898395,
-0.02303643,
-0.00028175875,
0.0057258373,
-0.02571137,
0.002423749,
-0.0118908435,
-0.16715053,
-0.032365452,
0.00894974,
-0.031460498,
0.03686361,
0.004158801,
0.011644643,
0.0008084709,
-0.0017350517,
-0.0034102167,
0.027122036,
0.020055402,
-0.04282567,
-0.03303086,
0.02362199,
0.02601746,
-0.0025618214,
0.030795088,
0.023768378,
0.0012268462,
0.015078149,
-0.039179232,
0.013960263,
-0.0025651483,
0.014319583,
0.033057477,
-0.011252052,
0.007445917,
0.009368947,
-0.003756229,
-0.013787257,
0.004245304,
0.039738175,
-0.024566868,
0.007898395,
-0.009575224,
-0.00012133302,
-0.013055308,
-0.0055029253,
0.007512458,
0.016355732,
-0.0006333854,
0.033962432,
0.008251061,
0.0017234071,
-0.0030009907,
-0.008337564,
-0.01097258,
0.02101359,
0.0035432985,
0.012050541,
0.0074658794,
0.03382935,
-0.0020411394,
0.043065216,
-0.0038127888,
0.0032721446,
0.013867105,
0.02194516,
-0.01579679,
0.028798865,
-0.023595372,
0.008031476,
-0.000624236,
0.020680886,
-0.0037329397,
-0.013920339,
0.011970692,
-0.030688623,
0.0032172485,
0.014599055,
-0.00032792144,
0.019469842,
-0.018804435,
0.020587727,
0.023675222,
-0.0017026131,
0.03223237,
-0.00090745033,
-0.016275883,
0.0018897591,
0.021066822,
-0.022663802,
-0.01455913,
0.03579896,
-0.017699856,
0.012948843,
0.01155814,
-0.0090894755,
0.025804527,
0.0067172954,
-0.037183005,
0.004824209,
-0.0254319,
0.031327415,
0.0016560345,
-0.020161867,
-0.017580083,
0.031540345,
0.020614345,
-0.0014772061,
0.012649409,
-0.011238744,
0.034228593,
0.038114578,
0.0034235248,
-0.013388012,
0.011671259,
0.02802699,
-0.009628456,
0.007106559,
0.015490701,
0.004162128,
0.018272107,
-0.010739688,
0.012875647,
0.005499598,
-0.022464179,
0.005303303,
-0.00323222,
0.06371948,
-0.0025119158,
0.009941198,
-0.00829764,
-0.0147986775,
0.0045414106,
-0.12445794,
-0.013261585,
0.0046878005,
0.0070932508,
-0.013654175,
0.017114297,
0.00062132487,
0.019057289,
-0.026682867,
-0.0030542235,
-0.010074279,
-0.01144502,
-0.0039491975,
-0.003139063,
0.03201944,
0.0071464833,
0.0040922603,
0.0069734775,
0.0010721389,
0.012103775,
0.015224539,
-0.022211324,
-0.00079724216,
-0.015118073,
0.021026898,
0.012037233,
-0.016794901,
0.0072596027,
0.020907125,
0.017726474,
-0.0009024598,
-0.009395563,
0.011611372,
0.0051136618,
-0.002857928,
-0.016861442,
-0.037369322,
-0.025591597,
0.009701651,
-0.0067039873,
-0.007698772,
0.010579989,
0.0060785036,
-0.029969983,
0.0076122694,
-0.016675128,
0.019523075,
-0.027055494,
-0.013022037,
-0.025658138,
-0.036384515,
-0.01491845,
-0.016249267,
0.010340443,
0.007871779,
-0.014785369,
-0.01322166,
-0.0042087063,
-0.006710641,
-0.012576214,
0.0052667055,
0.018139025,
-0.02281019,
-0.008796696,
0.0050970265,
-0.0105001405,
-0.017859554,
-0.019429918,
0.024872957,
-0.016781593,
-0.00023892311,
0.018285416,
-0.0014680567,
-0.0010031027,
-0.035905425,
0.009987776,
-0.036783762,
-0.009049551,
0.02810684,
-0.030289378,
-0.008530532,
-0.016275883,
0.026789332,
-0.01970939,
-0.0039491975,
0.015876638,
0.037928265,
-0.015224539,
0.013853798,
0.004185417,
-0.016116185,
0.02991675,
0.010267247,
-0.010699763,
-0.015637092,
-0.00996116,
0.0016227642,
0.0035532794,
0.04077621,
-0.012250164,
-0.027175268,
0.008144596,
-0.0596738,
0.039445397,
-0.025618214,
-0.021891927,
0.018351957,
-0.015783481,
0.0053665168,
0.011538177,
-0.003992449,
0.036198203,
-0.008264369,
0.02455356,
-0.012077157,
-0.009808116,
-0.012349975,
-0.0051036803,
0.030182913,
-0.0045281025,
0.0134079745,
0.02903841,
-0.023861537,
-0.0011395115,
0.029597355,
0.029597355,
-0.055894285,
-0.008523879,
0.006953515,
0.029277958,
-0.0072263326,
-0.0021409506,
0.000011956553,
-0.01666182,
-0.0040689707,
0.023009814,
-0.00022686258,
-0.009881311,
-0.00045580458,
0.00894974,
0.014811985,
0.055947516,
-0.014758753,
-0.03976479,
0.008936431,
-0.014732136,
0.002503598,
0.017646624,
0.006946861,
0.011844265,
0.0031690062,
0.018658044,
0.03303086,
0.018724585,
-0.0034800847,
-0.045327604,
-0.0052899946,
0.0058289752,
-0.0018581522,
-0.01948315,
0.01405342,
-0.02520566,
0.021758847,
0.008936431,
-0.011165549,
-0.0051136618,
-0.00673393,
-0.013800565,
-0.027468048,
0.010080934,
-0.00311411,
-0.008483954,
-0.024673333,
0.028186688,
0.017340537,
0.011737799,
0.0016443898,
-0.01245644,
-0.036384515,
-0.015703632,
0.0031107832,
-0.00034829957,
-0.0010912693,
-0.027947143,
0.0046079513,
0.0018331994,
0.014279659,
0.0103737125,
0.009395563,
-0.0021442778,
0.0028246576,
0.021612456,
0.023781687,
0.0018548252,
0.017380461,
0.000025589621,
-0.019283528,
0.036703914,
-0.009741575,
0.0013815537,
0.010713072,
0.03297763,
-0.01340132,
0.011019159,
0.024247473,
-0.016395656,
-0.014106653,
0.015477394,
-0.002049457,
-0.025085887,
-0.009215903,
0.00022914993,
-0.021066822,
-0.0015395881,
-0.015291079,
0.006697333,
0.003593204,
0.0008188679,
0.004764322,
0.0016884732,
-0.0040490087,
0.033137325,
0.019137139,
0.028665783,
0.020813966,
0.007439263,
0.004977253,
0.02823992,
0.026163848,
-0.0019795892,
0.01491845,
-0.0024287398,
0.021186596,
0.0057857237,
-0.02463341,
-0.017460309,
-0.010979234,
-0.014213118,
0.018139025,
0.0068337414,
0.0046146056,
0.05786389,
0.006544289,
-0.011984001,
0.04362416,
-0.04945313,
0.025591597,
0.015157998,
-0.003010972,
-0.018005945,
0.00017716491,
0.0049606175,
-0.017646624,
0.001366582,
-0.024806416,
-0.01170453,
0.0069069364,
-0.029544123,
-0.004265266,
-0.012130391,
-0.034441527,
0.019363377,
-0.029011795,
0.012855685,
0.0065143458,
-0.0044915047,
0.014745444,
0.015756864,
-0.031992823,
0.0061350632,
-0.0003551616,
0.017580083,
-0.016954599,
-0.029171493,
-0.0151979225,
-0.011957385,
-0.0046079513,
0.023369133,
-0.017074373,
0.04636564,
0.012982113,
-0.008943086,
-0.011538177,
-0.015610475,
-0.012416516,
0.019017365,
0.00894974,
0.0067638736,
-0.019669464,
-0.008989664
] |
This study represents the first phase III trial of the safety, tolerability, and effectiveness of tafenoquine for malaria prophylaxis. In a randomized (3:1), double-blinded study, Australian soldiers received weekly malaria prophylaxis with 200 mg tafenoquine (492 subjects) or 250 mg mefloquine (162 subjects) for 6 months on a peacekeeping deployment to East Timor. After returning to Australia, tafenoquine-receiving subjects received a placebo and mefloquine-receiving subjects received 30 mg primaquine daily for 14 days. There were no clinically significant differences between hemat | [
-0.018626414,
0.0007045521,
0.008290215,
-0.029812891,
-0.010542125,
0.027607482,
-0.01311289,
-0.024325937,
-0.021376533,
-0.0056696306,
0.010110343,
0.000076392214,
0.033081148,
-0.0014730411,
0.0015104068,
0.0017686457,
0.029254897,
0.003789718,
-0.015942723,
-0.0031902052,
-0.0027235483,
0.04107908,
-0.008210502,
-0.011472117,
-0.012136398,
0.0072340104,
0.009532419,
-0.022705093,
-0.016447576,
-0.011744472,
0.01197697,
-0.027062772,
-0.0077587916,
-0.019835403,
-0.028378045,
-0.025069932,
0.01489316,
-0.0040188944,
0.009372992,
0.0051382068,
0.016700001,
0.016088864,
0.0111731915,
0.021775102,
-0.015491012,
-0.025242643,
0.021243678,
0.00063314196,
-0.042407643,
0.027009629,
-0.0036037196,
0.0010395984,
-0.014202309,
0.023528801,
-0.009731703,
-0.029308038,
-0.012309111,
0.007971361,
0.0052345274,
-0.032151155,
-0.017962134,
0.0034509352,
-0.037465397,
0.01410931,
0.016899286,
0.0018483594,
0.009412849,
0.014122595,
-0.012236039,
0.00005781313,
0.03488799,
0.032071445,
0.008555927,
-0.013126175,
0.039777093,
-0.02495036,
-0.024312653,
0.014308593,
0.008137431,
-0.0059320214,
0.0370934,
-0.00056090154,
-0.026717346,
0.016367862,
0.016779715,
0.013225817,
0.020194115,
0.025362214,
0.004370963,
0.0021971064,
-0.002886297,
0.021163965,
0.006068199,
0.026863487,
0.0079381475,
-0.0008569213,
-0.011897257,
0.03754511,
0.0007344447,
-0.012880391,
-0.027527768,
-0.009140494,
0.0029726534,
-0.0031121522,
-0.023993798,
0.011585045,
-0.01434845,
-0.011219691,
0.0035837912,
-0.022598809,
-0.015451156,
0.048625305,
0.011764401,
-0.036269695,
-0.029972319,
-0.006875299,
-0.0027086022,
-0.015384727,
0.018373987,
-0.009578919,
0.00972506,
0.011704615,
0.024551792,
0.0036302907,
0.017669851,
0.0051448494,
-0.0064568026,
-0.025468498,
0.008854854,
0.0080245035,
0.002715245,
0.038421962,
0.030822597,
-0.01339853,
-0.024206366,
0.024764363,
-0.038368817,
-0.020247258,
-0.02803262,
-0.0030224745,
0.0038760745,
0.023688229,
-0.0047462815,
-0.015092444,
-0.018387273,
0.0060117347,
0.0054039187,
0.026969772,
0.005480311,
-0.014335165,
0.010947336,
-0.02824519,
0.0126146795,
0.013963168,
-0.008436358,
-0.011764401,
-0.005845665,
0.016607003,
-0.025335643,
-0.0046997815,
0.006659408,
-0.012940177,
0.011339261,
0.008303502,
0.0072472957,
0.009970845,
0.0023249805,
-0.018985126,
0.009904416,
-0.009014281,
-0.0077322205,
0.03247001,
0.00038735833,
0.024990218,
0.01242868,
-0.010834409,
0.013092961,
-0.009738347,
-0.008974425,
-0.0007170073,
-0.021695388,
0.037863966,
0.015158872,
0.00014873646,
-0.01667343,
0.023754656,
0.011485403,
-0.00031698617,
0.008124146,
0.010714838,
-0.016367862,
-0.00073693576,
-0.013923311,
-0.013670884,
-0.6445111,
-0.00777872,
0.009093994,
-0.016235005,
0.012202825,
-0.005912093,
0.019436836,
0.0064568026,
-0.018267702,
0.025534928,
-0.00405543,
0.030503742,
0.012103183,
-0.025295787,
-0.016793001,
-0.015876295,
-0.013777169,
-0.015530868,
0.016168578,
-0.011066906,
-0.027288627,
0.016155291,
0.004188286,
0.020406684,
-0.0010022327,
0.000035004447,
0.018068418,
-0.03130088,
-0.03379857,
0.04455991,
-0.016288148,
0.03555227,
0.0012762481,
0.0270362,
0.039165955,
-0.057021804,
-0.00006092694,
0.001468059,
0.0044838907,
0.01899841,
-0.017988706,
0.004663246,
0.028882898,
-0.018493557,
-0.0056198095,
0.01264125,
0.009167066,
0.00034065114,
0.010887551,
-0.009532419,
0.010442483,
-0.013259031,
-0.011252905,
0.009525777,
-0.0016432629,
0.030291172,
0.029866034,
-0.007406723,
0.022638666,
-0.0042082146,
-0.024976932,
-0.0069350842,
0.00076143106,
-0.022877807,
-0.012116469,
0.013498171,
0.006769014,
0.020326972,
0.015172157,
-0.019078124,
0.019184409,
0.0035804696,
-0.039458238,
0.0063571604,
0.027049486,
0.014401592,
0.019662691,
-0.0070612975,
-0.02141639,
-0.004188286,
-0.0048392806,
0.009751632,
-0.013365315,
0.0058788788,
0.04299221,
-0.014959588,
-0.026743917,
0.013219174,
0.015065873,
-0.0062973755,
-0.001745396,
0.018812412,
0.01700557,
-0.0064833737,
0.000050858944,
0.027089342,
0.026903344,
-0.013936597,
0.008695426,
-0.042274784,
-0.0108144805,
-0.00948592,
0.022824664,
-0.01999483,
0.002398051,
-0.0020991252,
-0.0107679805,
0.005101671,
0.035658557,
-0.005915414,
-0.01655386,
0.0017918956,
-0.028324904,
-0.022120528,
0.025149645,
-0.029653464,
0.008555927,
0.0073402952,
-0.0018051811,
-0.040069375,
0.029201753,
0.011518617,
0.029414322,
0.0013219174,
-0.0019496621,
0.010787909,
-0.009113923,
-0.009313207,
0.015437869,
-0.030370886,
0.0047994237,
0.023674943,
0.037013687,
-0.0047130673,
0.021110822,
-0.02483079,
0.02637192,
0.000091598,
0.0033878286,
-0.027979478,
-0.012906962,
-0.0098247025,
0.011624902,
0.012375538,
0.013458315,
-0.03680112,
0.002687013,
-0.0012330699,
-0.03241687,
-0.0013335423,
0.026345348,
-0.012242682,
-0.024113368,
-0.0021323392,
0.022120528,
-0.009392921,
-0.017908992,
-0.03355943,
-0.021615675,
-0.017497137,
0.025388785,
-0.0021290178,
0.007008155,
0.0038295747,
-0.014414879,
-0.019131267,
0.029866034,
0.0021339997,
0.02108425,
-0.029414322,
0.009924345,
-0.019343836,
-0.022093955,
0.027846621,
0.00045212565,
0.0065132664,
0.009047495,
-0.00090591196,
-0.004752924,
-0.0067490856,
-0.014175737,
0.011179834,
0.00046375053,
0.013724027,
0.03114145,
-0.011996899,
0.012780749,
0.005413883,
0.00424475,
0.039564524,
0.012069969,
-0.013405172,
-0.02295752,
0.015172157,
-0.00005480311,
-0.01193047,
0.007765434,
0.016500717,
0.011711258,
0.036747973,
0.016301434,
-0.0057925223,
0.011000479,
-0.02440565,
0.022492524,
-0.035392843,
-0.0019048232,
-0.008376572,
0.05091043,
0.029467465,
-0.007200796,
-0.016235005,
-0.021735245,
-0.019742405,
-0.008170646,
0.017324425,
-0.009266707,
-0.011777686,
-0.021270249,
0.012667822,
0.00032009996,
0.009545705,
0.011611616,
0.022585524,
-0.0016905928,
-0.0045536403,
0.024551792,
0.005284348,
0.003042403,
-0.0082968585,
-0.004311178,
-0.020114401,
-0.010336199,
0.025043359,
0.025601355,
0.016912572,
-0.013538028,
-0.020685682,
0.032098014,
0.009572276,
0.012289182,
-0.0018101633,
0.023249803,
-0.0007606007,
0.01652729,
0.0027467983,
0.012813963,
0.0022253382,
0.024206366,
0.035020847,
0.017443996,
0.023980511,
-0.01598258,
-0.024073511,
-0.023369374,
-0.0073270095,
-0.010243199,
0.038262535,
0.019038267,
0.027448054,
0.02736834,
0.00806436,
-0.005523489,
-0.019609548,
0.0031835623,
-0.008031147,
0.012833891,
-0.020127688,
0.003351293,
0.0005878879,
-0.031168023,
0.0030075281,
0.028643757,
0.0005895486,
0.008735283,
0.002255231,
0.0056563453,
0.004377606,
0.0186397,
-0.0123423245,
-0.025388785,
-0.028882898,
0.01043584,
0.01311289,
-0.008801712,
-0.010867623,
-0.0067291576,
0.0028265119,
-0.009585562,
0.023077091,
-0.0059818425,
0.0014414878,
-0.014149166,
-0.004038823,
-0.008901353,
-0.01930398,
0.02679706,
-0.0012446948,
-0.009578919,
-0.019901833,
-0.014986159,
-0.009911059,
-0.009691847,
-0.011697972,
0.01401631,
-0.0029294752,
0.00038839626,
-0.023302946,
-0.01410931,
0.021668818,
0.029361181,
-0.017297855,
0.0035970767,
0.018360702,
-0.0007502213,
0.014667304,
-0.024697933,
0.01842713,
0.030902311,
-0.05186699,
-0.015185443,
-0.038023394,
0.0029726534,
-0.001833413,
0.0489973,
0.009711775,
0.0006127984,
0.021429677,
0.022984091,
0.0021721958,
0.016939143,
-0.016155291,
0.027102629,
0.0012779088,
-0.029308038,
-0.00194468,
-0.005257777,
0.016806286,
0.0038295747,
0.014122595,
-0.0033330254,
-0.020247258,
0.015411299,
0.012408752,
0.013604457,
0.012960105,
0.032948293,
0.030131746,
0.025309073,
-0.012501751,
-0.011179834,
0.030477172,
0.012800678,
0.004676532,
0.025747497,
-0.023249803,
-0.0004882459,
0.022014242,
0.00296435,
0.003905967,
-0.024870647,
-0.006347196,
0.0074997223,
-0.008496143,
0.017324425,
0.02821862,
0.00072157424,
0.002770048,
0.00998413,
-0.0077056494,
-0.00969849,
-0.0038594673,
-0.00872864,
-0.010575339,
0.02914861,
0.012435324,
-0.031858873,
-0.022638666,
0.003457578,
-0.0049987077,
-0.021310106,
-0.004786138,
-0.011166548,
-0.011485403,
0.0057493444,
-0.029334608,
0.017417423,
0.016832858,
-0.010674981,
-0.030902311,
-0.011226334,
-0.0053939545,
-0.010336199,
-0.016766429,
0.0022469275,
-0.017337712,
-0.00806436,
0.009472635,
0.02395394,
0.02383437,
-0.0002601072,
-0.004178322,
-0.013763884,
0.026770487,
-0.0031038488,
0.006111377,
-0.009220208,
-0.022054099,
0.017510423,
0.009791489,
0.020738825,
-0.004693139,
-0.000060563663,
0.0019911795,
0.013777169,
-0.003989002,
0.010170128,
-0.010349484,
-0.024179796,
-0.0029045648,
-0.0006509945,
0.039112814,
-0.018626414,
-0.009220208,
0.0033114364,
-0.023435801,
-0.012036756,
-0.012581465,
-0.0039026455,
0.016248291,
-0.005606524,
-0.00045876845,
-0.03422371,
-0.035924267,
-0.003196848,
-0.01612872,
-0.013631028,
0.0022353025,
0.027009629,
0.009811417,
0.0031486878,
0.029945748,
0.013033176,
0.0013459976,
-0.0095124915,
0.018227845,
0.026265636,
-0.0018898769,
-0.019024983,
0.026757203,
0.0044606407,
-0.006815514,
-0.014428164,
-0.003690076,
-0.0115319025,
0.032177728,
-0.002713584,
-0.0023017304,
-0.027315198,
-0.020592684,
-0.01510573,
-0.0012347306,
0.0006908513,
-0.00042389374,
0.008509428,
-0.011970327,
-0.011525259,
-0.0073004384,
0.016806286,
-0.0203004,
0.004752924,
-0.016301434,
-0.04044137,
-0.0046698893,
-0.021482818,
-0.011717901,
-0.021177249,
0.0020393399,
-0.022545667,
-0.0029211717,
-0.007479794,
-0.02150939,
0.030636597,
0.021057678,
0.022877807,
-0.022372954,
-0.013843597,
0.0051548136,
0.0006240081,
0.0088349255,
-0.00046001398,
0.022067385,
-0.02999889,
0.0073934374,
0.019330552,
0.01477359,
-0.007971361,
-0.009718418,
0.018666271,
0.036535405,
-0.023183376,
-0.020592684,
0.00039711496,
-0.025641212,
-0.007513008,
0.016168578,
-0.00048035756,
0.009000995,
-0.016686717,
-0.0044074985,
0.048226736,
0.009140494,
0.004659925,
0.0084297145,
0.021655532,
-0.0058689145,
-0.001057866,
-0.0115319025,
0.019782262,
0.002426283,
0.007831862,
0.0043975343,
-0.016474146,
0.016301434,
-0.013458315,
0.002271838,
0.014335165,
0.007878362,
-0.018028563,
0.013073033,
-0.017470567,
-0.007951433,
-0.009406206,
-0.017497137,
-0.011213048,
-0.011963685,
0.0064302315,
-0.01565044,
-0.0032217584,
0.012621322,
0.0015809867,
-0.007978004,
-0.014786875,
-0.005689559,
0.0013833633,
-0.0057526655,
0.019569691,
-0.0057892012,
0.0007543731,
0.031593163,
0.0042414283,
-0.015158872,
-0.004121858,
0.005324205,
0.003168616,
0.023914084,
0.03929881,
-0.040547658,
-0.012528323,
0.0421685,
0.0066461223,
-0.008868139,
-0.032124586,
0.01987526,
0.0021589103,
-0.0016092185,
-0.010488983,
0.012036756,
-0.03528656,
0.038315676,
0.0034974348,
-0.0035140417,
0.019317266,
-0.0184537,
-0.03161973,
0.00948592,
0.0025109788,
0.015663724,
-0.002687013,
-0.020167544,
0.008914639,
-0.019529834,
0.010010701,
0.0015643797,
-0.018905412,
0.033772,
0.005201313,
-0.018892126,
-0.004546997,
-0.0048160306,
-0.019131267,
0.01043584,
-0.016235005,
0.027846621,
-0.014720447,
0.014149166,
0.0115319025,
0.000003076512,
-0.0146805905,
-0.016075578,
-0.0049455655,
-0.023767943,
-0.0077853627,
0.004925637,
0.005085064,
0.011279476,
-0.027089342,
-0.008947853,
-0.0184537,
-0.018958554,
-0.0014937998,
-0.021310106,
0.01945012,
-0.040760227,
-0.0004762058,
0.00039088732,
-0.0042646783,
0.008622356,
-0.003939181,
-0.010967265,
-0.01794885,
-0.007406723,
-0.0019911795,
-0.0011242941,
0.023754656,
0.017603423,
-0.02483079,
-0.027341768,
-0.023635086,
-0.029839462,
-0.014082738,
-0.018679557,
-0.03068974,
-0.016181864,
-0.014414879,
0.021070965,
-0.00054304895,
-0.048279878,
0.03504742,
0.032629438,
0.013604457,
-0.020552827,
-0.009432778,
0.01885227,
-0.006343875,
0.015783295,
0.02286452,
-0.015969293,
-0.012986676,
-0.03225744,
-0.00794479,
0.015663724,
-0.031885445,
0.010442483,
0.0058257366,
0.007924861,
-0.030397458,
-0.009000995,
-0.014574305,
-0.01022327,
0.0038993242,
0.0007581097,
0.002482747,
-0.017404139,
0.005606524,
-0.013418458,
-0.017563567,
-0.0107679805,
-0.008157359,
0.0073602237,
-0.00057792367,
-0.014534448,
-0.022851236,
-0.015690297,
-0.007811934,
0.048439305,
-0.023249803,
-0.025109788,
-0.0029792963,
-0.022253383,
-0.04349706,
0.0066959434,
-0.0043144994,
0.0054205256,
-0.0044872123,
0.005822415,
0.01800199,
0.03879396,
-0.013172674,
-0.012873748,
-0.0053607402,
-0.016500717,
-0.013670884,
-0.03361257,
0.027926335,
-0.022333097,
-0.061485767,
0.010462412,
0.017364282,
-0.027235484,
-0.039803665,
0.0067059076,
-0.009339779,
-0.005779237,
-0.039165955,
0.0014331844,
-0.008761855,
-0.028882898,
-0.00436432,
-0.008004575,
-0.0020293756,
-0.018280989,
0.0066726934,
-0.03132745,
-0.022426097,
0.02827176,
0.0078916475,
0.001800199,
-0.03443628,
-0.026876774,
-0.008356644,
-0.035233416,
0.02172196,
0.010090414,
-0.004659925,
-0.005845665,
0.012833891,
-0.0066826576,
0.008177288,
0.024591649,
0.0066793365,
-0.003856146,
0.014454735,
0.019330552,
0.020380113,
0.0074000806,
0.0055666673,
0.025069932,
0.0017752886,
0.0075196507,
-0.03130088,
-0.017789422,
0.009904416,
0.02625235,
-0.034542564,
-0.010595268,
-0.007479794,
0.001346828,
0.005805808,
-0.009499205,
0.0046067825,
-0.014760304,
-0.013451672,
0.004493855,
-0.012289182,
0.0060648774,
-0.005639738,
0.019981546,
-0.0063571604,
0.0086555695,
0.16165921,
0.014175737,
0.004849245,
0.022691809,
-0.010063844,
0.01643429,
0.04020223,
0.0034542566,
-0.008622356,
0.02084511,
0.024392365,
-0.01764328,
-0.007685721,
-0.0012513376,
-0.0064302315,
-0.0026023174,
-0.023023948,
-0.022000957,
0.0034044355,
-0.0015544154,
0.0042115357,
0.010887551,
0.013644313,
0.006111377,
-0.0029228325,
0.0021987671,
-0.0057194517,
-0.00063687854,
-0.0073668663,
-0.0060748416,
-0.014600877,
-0.022465954,
-0.005111635,
0.00074357854,
-0.019357122,
-0.0057094875,
-0.011452189,
-0.0036103623,
-0.011438903,
0.0065531232,
-0.0022452667,
0.020061258,
-0.0320183,
-0.012269254,
-0.010748052,
0.027926335,
-0.0071941535,
-0.01909141,
-0.03488799,
0.00372329,
-0.03929881,
-0.009764917,
0.0036767903,
-0.0096453475,
-0.015823152,
-0.018440416,
0.03464885,
-0.016301434,
0.006436874,
0.032124586,
-0.01510573,
0.00040853227,
-0.003905967,
0.03531313,
-0.016633574,
0.025016788,
-0.015716868,
0.01098055,
-0.0039989664,
-0.0022950878,
-0.01999483,
-0.004337749,
-0.015158872,
0.017151712,
0.0011010442,
-0.029440895,
0.012787392,
0.019357122,
-0.005290991,
-0.011332619,
0.0006256688,
-0.0146805905,
0.0049854224,
0.0061412696,
-0.007214082,
-0.010376055,
0.025348928,
0.0010952319,
-0.025880354,
0.008628999,
0.0080710035,
-0.01197697,
-0.013524743,
-0.0065630875,
0.0008834925,
-0.0040919655,
0.012415395,
0.027607482,
-0.004958851,
-0.035153702,
-0.040494516,
0.06600287,
-0.014786875,
0.017377567,
0.0076657925,
0.008170646,
-0.0043144994,
0.015836438,
-0.009133851,
-0.013245746,
0.014069453,
-0.0355257,
0.0031437057,
-0.017032143,
0.0030872417,
0.02138982,
-0.015305013,
-0.017164998,
0.02779348,
-0.01764328,
0.015437869,
-0.035924267,
-0.00023955602,
0.020725539,
-0.026464919,
-0.011830828,
-0.008994353,
0.0035240059,
0.013577885,
-0.020074544,
0.0025774068,
-0.01788242,
0.005995128,
0.009924345,
0.011611616,
0.0077587916,
-0.006609587,
0.0007410875,
-0.018838983,
0.01945012,
0.032496583,
-0.016301434,
0.012960105,
0.001515389,
-0.007997933,
-0.023342803,
0.0061678407,
-0.0062741255,
-0.02570764,
-0.006127984,
0.0080710035,
-0.037970252,
0.001238052,
-0.013597813,
0.032948293,
-0.008183931,
0.006566409,
-0.01894527,
0.0252825,
0.001171624,
-0.04413477,
-0.0022651951,
0.018480273,
-0.009798132,
-0.0015402995,
0.036535405,
-0.16718602,
0.033028007,
0.026305493,
0.0063804104,
0.030317744,
0.005297634,
0.028006049,
-0.007486437,
-0.025973352,
-0.014215594,
0.020791966,
0.0017586816,
-0.004679853,
-0.014149166,
0.0091072805,
-0.00915378,
-0.049103584,
0.01800199,
0.035924267,
0.03510056,
0.027169056,
0.0031769197,
0.01610215,
-0.02912204,
0.024565078,
0.028989183,
0.0024213009,
0.0026720667,
-0.004334428,
0.009233493,
-0.032974865,
0.0052544554,
0.03794368,
0.005400597,
0.011252905,
-0.0061578765,
-0.005191349,
0.021310106,
-0.0064734095,
0.023316232,
0.020114401,
0.009632061,
0.017443996,
-0.011837471,
-0.017337712,
0.029839462,
-0.0007261412,
-0.017390853,
0.0023283018,
0.0011301065,
0.002266856,
-0.011631545,
0.020034688,
0.024751076,
-0.007911576,
-0.014946302,
-0.0027418162,
-0.016899286,
0.019782262,
-0.020698968,
-0.01401631,
-0.0008569213,
0.024844076,
-0.017204855,
0.004666568,
-0.018626414,
-0.00806436,
-0.006493338,
-0.003158652,
0.018347416,
-0.027182342,
0.002271838,
0.010973907,
-0.008516071,
0.01064841,
0.014375022,
-0.0028132263,
0.0018118239,
0.01043584,
0.037199687,
-0.023449088,
0.029600322,
0.0010362769,
0.014986159,
-0.0019015018,
0.004928958,
-0.02053954,
0.024485365,
-0.023063805,
-0.009253422,
-0.004928958,
-0.004666568,
-0.0053275265,
-0.012269254,
0.023422517,
0.008841569,
0.00082951976,
0.01887884,
-0.016939143,
-0.02374137,
0.017510423,
-0.015663724,
-0.041902788,
-0.0035372914,
0.03924567,
0.0037033616,
0.001956305,
0.00457689,
0.026079636,
0.010302984,
-0.012441967,
0.012255968,
0.010495625,
0.010216628,
-0.010329556,
0.023356088,
0.012800678,
-0.028962612,
-0.004875816,
-0.015995866,
0.061698336,
0.005769273,
0.0016025758,
0.022851236,
-0.017629994,
-0.0019430193,
-0.12849835,
0.021522675,
0.01240211,
-0.0027335125,
0.0044739265,
0.0071011544,
-0.0055434173,
0.017962134,
0.013856883,
0.0075329365,
-0.0070280833,
-0.0076392214,
-0.0025906924,
-0.018466987,
0.037199687,
0.013039818,
0.01987526,
-0.012083255,
-0.016766429,
0.04990072,
-0.015318299,
-0.004062073,
0.0064634453,
-0.01031627,
0.012136398,
-0.016288148,
-0.010216628,
-0.004643318,
0.0055102035,
0.0489973,
0.0054072402,
-0.012601393,
0.013166032,
0.008117503,
-0.013750598,
-0.0039258953,
-0.009279993,
-0.0062973755,
0.023449088,
-0.042806208,
-0.0021290178,
0.0022635343,
-0.0020011438,
0.0014190683,
0.04243421,
0.008004575,
-0.013817026,
0.010681624,
0.007546222,
-0.0074997223,
-0.003014171,
-0.030397458,
-0.013205889,
-0.013212531,
0.031912018,
0.0006825478,
0.0032881866,
0.029706607,
-0.019888546,
-0.0038295747,
0.012787392,
0.00047911203,
0.01268775,
0.015610582,
0.008688783,
0.0049887435,
-0.015358156,
-0.024392365,
0.005257777,
0.0016764769,
-0.00965199,
-0.015517583,
-0.009426135,
0.0016083881,
-0.030158317,
0.012302468,
-0.022186955,
-0.012581465,
0.0055766315,
-0.014069453,
-0.01413588,
0.0051448494,
-0.0070280833,
0.0082503585,
0.041397937,
0.043842487,
0.008137431,
-0.001152526,
0.008084289,
-0.0061479122,
-0.01797542,
0.019901833,
-0.018387273,
-0.019582978,
0.0005932852,
0.012980034,
0.00052229024,
-0.03114145,
0.001581817,
0.009346421,
-0.011917185,
-0.032842007,
-0.061964046,
0.0030739561,
0.027713766,
-0.0017603423,
0.004271321,
0.014029596,
0.024751076,
0.021589104,
0.0026405135,
-0.024697933,
-0.019649405,
-0.0065763732,
-0.028617186,
0.0019230909,
-0.028750043,
0.028590616,
0.008350001,
0.02383437,
0.034781706,
0.0059287,
-0.013345387,
0.0035306488,
-0.016155291,
0.015371442,
0.019104695,
0.0025143002,
0.01755028,
-0.002155589,
-0.021442961,
0.019476693,
0.008682141,
-0.0050518503,
-0.015703581,
0.0016507361,
-0.032762293,
-0.007187511,
0.0018732699,
0.00623759,
0.011724544,
0.01842713,
-0.012681107,
-0.009286636,
0.047403026,
-0.018931983,
-0.013617742,
0.0073270095,
-0.015212014,
0.015251871,
0.0056264526,
-0.017988706,
0.0059419856,
0.0010462411,
-0.007725578,
-0.012216111,
-0.024684649,
0.0012114808,
-0.0100040585,
-0.0091936365,
-0.011259547,
-0.03292172,
0.014494591,
0.016500717,
-0.018666271,
0.007380152,
-0.005819094,
0.00030037915,
-0.018373987,
0.0017885742,
0.00028086593,
-0.01565044,
-0.0032616153,
0.005281027,
0.00039088732,
-0.0020061259,
-0.00675905,
0.029759748,
0.004613425,
0.017696422,
-0.010608553,
0.012720964,
0.0021589103,
-0.033240575,
-0.040494516,
0.031061737,
0.0011965345,
0.020074544,
-0.0026438348,
0.024445508,
-0.021310106,
0.0084895,
-0.01830756,
0.009299922,
-0.0027384947,
0.0029593678,
-0.019330552,
0.034967706,
0.02625235,
0.009027567,
-0.0022818022,
0.044055056,
-0.0011998559,
0.0053109196,
0.011883971,
-0.019317266,
-0.00761265,
-0.014986159,
-0.03621655,
-0.03223087,
-0.0008137431,
0.010190057,
0.026956487,
0.015597297,
0.017497137,
-0.0024395688,
-0.01894527,
-0.012594751,
0.0035140417,
0.01064841,
-0.024751076,
0.021044394,
-0.014707161,
0.036535405,
0.013245746,
-0.01610215,
0.017815992,
-0.02872347,
0.030477172,
-0.004427427,
0.015863009,
-0.00092750107,
0.013431744,
0.021376533,
-0.033586003,
-0.0069550127,
-0.008668856,
-0.017204855,
0.018174704,
0.007473151,
0.0067125503,
0.08423071,
0.0013169353,
-0.022798093,
-0.005101671,
0.0117577575,
0.008436358,
-0.009877845,
0.033134293,
-0.000016010188,
-0.032310583,
0.011106763,
-0.0036103623,
0.023130232,
-0.025242643,
-0.05744694,
0.0003778093,
0.0068885847,
0.014866589,
-0.013524743,
0.0042347857,
0.024392365,
-0.0017736278,
-0.005035243,
0.00044506768,
-0.0050518503,
-0.0033778644,
0.022479238,
0.001695575,
-0.0082968585,
-0.024339223,
-0.009353064,
-0.0051315636,
-0.015092444,
-0.029201753,
0.017563567,
0.00020281303,
-0.016354576,
-0.008409786,
0.020977966,
-0.010608553,
-0.009140494,
0.033931427,
-0.016819572,
-0.018134847,
-0.0082503585,
-0.021323392,
-0.01712514,
-0.0062209833,
-0.01489316
] |
Studies of replication timing provide a handle into previously impenetrable higher-order levels of chromosome organization and their plasticity during development. Although mechanisms regulating replication timing are not clear, novel genome-wide studies provide a thorough survey of the extent to which replication timing is regulated during most of the early cell fate transitions in mammals, revealing coordinated changes of a defined set of 400–800 kb chromosomal segments that involve at least half the genome. Furthermore, changes in replication time are linked to changes in sub-nuclear organization and domain-wide transcriptional potential, and tissue-specific replication timing profiles are conserved from mouse to human, suggesting that the program has | [
-0.01804903,
-0.0131084565,
0.0049671354,
-0.030891864,
-0.027518462,
-0.0083671,
-0.015432651,
0.015485776,
-0.031369984,
0.0008404453,
0.0052925227,
-0.001746466,
0.020599004,
-0.004671631,
-0.0023540768,
0.002558274,
0.02187399,
-0.021781022,
-0.0036622663,
-0.0020585721,
-0.02140915,
0.0010932015,
0.0024653063,
-0.010359267,
0.0006565849,
0.01733185,
0.0032804343,
-0.024437245,
0.0050733844,
-0.021621648,
0.020705251,
-0.005246039,
-0.008851861,
-0.0067833276,
-0.016269362,
-0.02354741,
0.0116873775,
-0.012776429,
0.0055382233,
-0.024012249,
0.0068464126,
0.028660636,
0.00031936922,
-0.0031625645,
-0.014848282,
0.012995567,
0.028155955,
-0.011488161,
-0.015684992,
0.012723304,
0.00020751735,
0.025871605,
-0.021077123,
0.0076831225,
-0.019881822,
-0.016800605,
0.005418693,
0.020997437,
-0.015193591,
-0.027651273,
0.0068464126,
-0.015286558,
-0.017132632,
0.009622165,
-0.0139982905,
0.0073444545,
-0.004831004,
-0.00034115853,
0.009223731,
0.00214988,
0.026854407,
0.021834146,
-0.005667714,
0.0019473429,
0.019921666,
-0.0274919,
-0.012942443,
-0.00014090429,
-0.0005055123,
0.024570055,
0.01243112,
-0.005631191,
0.0075503117,
0.023162257,
-0.007749528,
-0.004170269,
0.0059134145,
0.0011405154,
-0.004648389,
0.012484244,
0.026389567,
0.0143436,
0.03514182,
0.02451693,
-0.0015505697,
0.0062819654,
0.002520091,
0.027784085,
-0.019934947,
-0.0149943745,
-0.027332526,
0.0033684217,
-0.0013853859,
-0.005322405,
-0.008420224,
-0.009197169,
0.03716055,
-0.02475599,
0.00873233,
-0.02855439,
-0.034716822,
0.027677836,
-0.012338152,
-0.012510806,
0.029430943,
0.003924568,
0.006959302,
-0.0057274792,
0.01159441,
-0.007855777,
0.03490276,
0.031423107,
0.020824783,
-0.034132455,
0.014861563,
-0.003360121,
-0.008792096,
0.015087342,
0.007576874,
-0.008858501,
0.004110504,
0.0020303498,
0.0056013083,
0.035938688,
-0.03864803,
-0.0063682925,
0.006145834,
-0.0027558305,
-0.016574826,
-0.020147445,
0.02284351,
0.028076269,
-0.024570055,
-0.00009800007,
-0.000586029,
0.02522083,
0.0008616121,
0.013799074,
0.017398255,
0.0024918683,
0.017119352,
-0.0020120882,
0.013188143,
0.012969005,
0.009980755,
0.022564607,
0.015764678,
0.017597472,
-0.017849812,
-0.01780997,
0.023241945,
0.008646003,
0.0167342,
0.008533114,
-0.007377657,
0.029510628,
0.0007503828,
-0.004160308,
0.017517785,
-0.018912302,
-0.027651273,
0.0061989585,
-0.021953676,
0.0139982905,
-0.03349496,
0.017172476,
0.0020652127,
0.018925583,
-0.010890511,
-0.012544009,
-0.0018842577,
-0.0012401238,
0.022883354,
0.013307673,
-0.02940438,
0.009389745,
0.0101202065,
-0.021555243,
0.022418516,
-0.00908428,
0.015950615,
-0.002139919,
-0.010963557,
-0.0047147945,
-0.6421683,
-0.0041769096,
0.008048353,
-0.036682427,
-0.0018444143,
0.020838063,
-0.0022494881,
0.0005814636,
-0.021063842,
0.018248247,
0.0038282801,
0.0151006235,
0.031635605,
-0.038063664,
-0.041968312,
-0.04504953,
0.0017149234,
-0.0022677497,
0.011660815,
0.009217091,
-0.025898166,
-0.010936995,
0.017079508,
0.010312783,
0.0012973985,
0.009914349,
0.029484067,
-0.01051864,
-0.018234964,
0.04077301,
-0.013838918,
-0.001972245,
-0.010319423,
-0.003026433,
0.045262028,
-0.019762293,
-0.0064712213,
0.012617055,
0.030094998,
0.050760407,
-0.028076269,
-0.0077296067,
0.0049306126,
0.011176054,
-0.016959978,
0.005833728,
0.008778814,
-0.00064496393,
0.007351095,
-0.018234964,
0.0085928785,
0.0026313202,
-0.014303757,
-0.0015713214,
0.019735731,
0.01854043,
0.011043244,
-0.004482375,
0.017624034,
-0.008665925,
-0.013022129,
0.0118998755,
-0.013892042,
-0.006358332,
-0.024052091,
0.025539577,
-0.013772512,
0.0064944634,
0.018009186,
0.0036655867,
-0.005694276,
0.017504504,
0.0050501423,
-0.027571587,
0.013467046,
0.018580275,
0.014622503,
0.009104202,
-0.014038134,
0.012537369,
-0.013234627,
0.0026744837,
-0.007981948,
-0.0065907515,
0.014609222,
-0.0083671,
-0.018314652,
0.0052294373,
-0.0051132278,
0.00022100599,
-0.0048476052,
-0.007470625,
-0.0036722273,
-0.027571587,
-0.031130925,
0.027810646,
0.0120260455,
0.011096369,
-0.014927968,
-0.03439808,
0.006630595,
-0.002843818,
0.0016667794,
0.010126847,
0.020253694,
0.0024520252,
-0.022046644,
0.006720242,
0.030254371,
0.0097815385,
0.007457344,
0.019390421,
-0.016176393,
-0.0016460277,
-0.011468239,
-0.022245862,
0.01923105,
0.013121737,
-0.0060196635,
-0.0064114565,
0.0160303,
-0.013772512,
0.0023706784,
-0.007968667,
0.014622503,
0.004485695,
0.024397401,
-0.0068464126,
0.013838918,
-0.025845041,
0.011136211,
-0.007796012,
0.016176393,
-0.024689585,
0.018620117,
0.00825421,
0.03179498,
-0.012517447,
-0.006275325,
-0.035168383,
-0.016242798,
-0.008579598,
-0.004077301,
-0.024118498,
0.011368631,
-0.039763644,
-0.01864668,
-0.0029932305,
0.024490368,
-0.015924051,
0.0036954691,
0.008798736,
-0.015326402,
0.029563753,
0.0006835622,
0.0010500378,
-0.016999822,
-0.05309788,
-0.013958448,
-0.0066538365,
0.0020652127,
0.010372547,
-0.017132632,
0.0030596359,
0.01194636,
-0.018965427,
-0.0061093112,
-0.0019440226,
-0.0056975964,
-0.032830905,
0.0077163256,
-0.008134681,
-0.044438597,
-0.008201086,
0.009934271,
0.016163113,
0.0013920264,
0.017783407,
-0.01326783,
-0.011999484,
0.0045853034,
-0.0067634056,
-0.022737263,
-0.017770126,
0.033627775,
0.036602743,
0.027000498,
-0.0048243636,
-0.015485776,
0.03490276,
0.016056864,
0.019138081,
-0.016933417,
0.0063882144,
0.005989781,
-0.009701852,
-0.010113566,
-0.0009047757,
0.009044437,
0.035460565,
0.040321454,
-0.023374755,
-0.009077639,
-0.025486453,
0.0074971872,
-0.026216913,
0.0040540593,
-0.0054718177,
-0.011786986,
-0.0120260455,
-0.0023889397,
0.0069393804,
-0.000466084,
-0.000967861,
0.010737779,
0.016388891,
-0.028182518,
-0.00025524636,
-0.025273954,
-0.0003083708,
0.009881146,
-0.007855777,
0.029138757,
0.0013770852,
-0.010804184,
0.009901068,
-0.002043631,
0.036283996,
0.015233434,
-0.0012285027,
-0.020784939,
0.018434182,
-0.025287235,
-0.00051090773,
0.033441838,
0.039391775,
0.0051796334,
-0.017013103,
-0.0025333718,
0.03599181,
0.012802991,
-0.011966281,
0.014742034,
-0.014051415,
0.0051929145,
-0.01577796,
0.019005269,
0.010936995,
-0.021249777,
-0.011282303,
-0.0053688893,
-0.0084667085,
-0.03370746,
0.012404557,
0.010219815,
-0.011846751,
0.011654175,
-0.0093167,
0.027518462,
0.012836194,
0.010810824,
-0.0023573972,
-0.013652982,
-0.038807407,
0.011023322,
-0.020877907,
0.020227132,
-0.019762293,
-0.003884725,
-0.0051663523,
0.0070456294,
0.008028432,
0.017145915,
-0.03646993,
0.018859178,
-0.026947374,
0.008672565,
0.0086991275,
0.020174008,
-0.0019174604,
-0.0035958607,
-0.031024676,
0.02259117,
0.015751397,
-0.005760682,
-0.003456409,
-0.008300695,
-0.016335767,
-0.015738117,
-0.0054319743,
-0.0027309284,
0.00274753,
-0.007092113,
-0.0011463258,
-0.018606836,
-0.010306142,
0.036762115,
-0.027890332,
-0.007470625,
-0.02534036,
0.0047745593,
0.030573117,
-0.006169076,
-0.005212836,
0.025911447,
0.019416984,
0.0042499555,
-0.016959978,
-0.017477943,
-0.015950615,
-0.0019772253,
-0.025114581,
-0.010166691,
-0.015764678,
-0.011514723,
0.004947214,
-0.0037585543,
-0.0073178923,
0.0061192717,
0.004648389,
-0.009396386,
-0.00076822925,
-0.026867688,
-0.0016153151,
0.027518462,
0.022219298,
0.0047645983,
0.022152893,
-0.010193253,
-0.006620634,
-0.008486629,
-0.014768595,
0.036044937,
-0.023095852,
-0.0017248843,
-0.0013538433,
0.009290137,
0.011906516,
-0.0066870395,
0.02103728,
0.013015489,
-0.009642087,
-0.020041196,
0.008904985,
0.010253018,
0.0037220314,
0.031529356,
0.046908885,
0.018859178,
-0.013168221,
0.0034398078,
0.020838063,
-0.009303418,
-0.013652982,
-0.004376126,
0.018195122,
-0.006703641,
0.036390245,
0.00044782244,
-0.012039327,
0.022816949,
0.00026769738,
0.00251179,
0.020917749,
0.0028072947,
0.010691294,
0.016548265,
0.007112035,
0.027916895,
-0.0063848943,
0.013015489,
0.021382589,
-0.023852875,
-0.012291668,
0.015924051,
-0.02522083,
-0.023879437,
-0.0030314135,
0.014516254,
-0.0018842577,
-0.0021631608,
-0.019749012,
-0.019881822,
-0.020944312,
-0.0027890333,
-0.016840449,
0.018022468,
-0.007264768,
-0.0063749333,
-0.005056783,
-0.0092303725,
-0.020373223,
-0.028315328,
-0.009469432,
-0.009270215,
-0.041968312,
-0.04109176,
0.0075370306,
0.027810646,
0.020532597,
0.025048176,
-0.015485776,
-0.02583176,
0.032937154,
-0.0070389886,
-0.018819334,
-0.0093565425,
-0.017730283,
-0.01937714,
0.005295843,
0.013088535,
-0.010452234,
-0.0121322945,
-0.000035018555,
0.010704575,
-0.009814741,
0.04114488,
0.0031459632,
-0.021116966,
0.019005269,
0.013799074,
0.05450568,
-0.00048600565,
-0.012842834,
-0.026575502,
-0.0037817964,
-0.018009186,
-0.01063153,
-0.010445594,
-0.0021133567,
-0.0012683461,
0.0104588745,
-0.020771658,
-0.0014675627,
0.01613655,
-0.026721595,
0.014635785,
0.01591077,
0.03708086,
0.024716148,
-0.00048476056,
0.013613138,
-0.009070999,
-0.0007520429,
-0.028341891,
-0.0011554566,
0.011913156,
0.01004716,
-0.012424479,
0.005777283,
-0.003311977,
-0.010810824,
-0.017013103,
0.010531921,
0.000513813,
0.032246538,
-0.0001541854,
-0.026376287,
0.0037220314,
-0.009854584,
0.009595603,
0.018314652,
-0.01925761,
0.0040474185,
0.00038058683,
0.0039046465,
0.00046068855,
-0.0067700464,
0.013413922,
-0.032937154,
0.002930145,
-0.0040706606,
0.01637561,
0.011767064,
0.012052608,
-0.010817464,
-0.021913832,
-0.01864668,
-0.025446609,
-0.028660636,
-0.00096288056,
-0.030918427,
0.04390735,
0.016933417,
0.033282463,
-0.00009800007,
-0.023109132,
0.026455972,
0.033176214,
-0.011222539,
-0.0054585366,
0.006886256,
-0.013121737,
0.008665925,
0.007829214,
-0.010432312,
0.013247908,
-0.011541286,
0.010810824,
0.03994958,
0.0002842988,
-0.021090403,
0.004475734,
-0.016999822,
-0.006275325,
0.016880292,
0.0030214528,
-0.005199555,
-0.021143528,
-0.005319085,
0.009808101,
0.008513192,
0.0298825,
-0.024357557,
0.03708086,
-0.021316184,
0.026482536,
-0.019191206,
0.028049706,
-0.025672387,
0.0040839417,
-0.023799751,
0.012603775,
0.023985686,
-0.0023507567,
0.024702866,
-0.011036603,
-0.012404557,
0.0052792416,
-0.0019290814,
-0.04518234,
-0.022206018,
-0.011528004,
-0.0041337456,
0.013374079,
-0.009867866,
-0.010432312,
-0.024091935,
0.012271746,
0.008147961,
-0.0042532757,
0.01076434,
-0.0031526037,
-0.0106713725,
0.029245006,
0.010126847,
0.014688909,
-0.019217767,
0.043827664,
0.0061126314,
0.021581804,
-0.00089979527,
-0.017106071,
-0.022391953,
0.0015157068,
0.039285526,
0.021183372,
-0.013838918,
-0.0021349385,
0.012278387,
0.006985864,
-0.027784085,
-0.04791825,
0.0031393226,
-0.0037983977,
-0.004757958,
-0.011494801,
0.0068331314,
-0.01925761,
0.00055448635,
-0.0099077085,
0.015631868,
0.02522083,
-0.022272423,
-0.007065551,
0.033548087,
-0.0042433147,
0.007351095,
-0.029723126,
-0.01923105,
0.0047247554,
-0.0031941072,
-0.0104389535,
-0.023255225,
-0.015113904,
0.013719387,
-0.0128959585,
-0.007922183,
0.015552181,
0.0033850232,
-0.012603775,
-0.025526294,
-0.009708492,
0.04651045,
-0.02438412,
-0.0020967554,
0.0008383701,
0.0332559,
-0.010080364,
-0.0034464484,
-0.0036157824,
-0.019177925,
-0.029696563,
0.012982286,
0.01997479,
0.023241945,
0.008161243,
-0.039843332,
-0.011282303,
-0.016920134,
-0.029670002,
-0.022166174,
0.009117482,
-0.04746669,
-0.0018792772,
0.021462275,
0.027571587,
0.017477943,
0.012517447,
-0.0073842974,
-0.016043581,
0.030413743,
-0.012729945,
0.025486453,
0.0052294373,
-0.008400302,
-0.01972245,
0.009190529,
-0.013287751,
-0.0063948547,
0.008294053,
-0.013785793,
-0.01804903,
0.028262204,
0.013374079,
0.03429183,
-0.0063085277,
-0.0068596937,
0.0121322945,
0.00080848765,
0.0049704555,
-0.010432312,
-0.009728414,
0.013234627,
-0.021342745,
0.0065542283,
0.03309653,
-0.013971728,
0.007849136,
-0.008559676,
-0.012019405,
0.02605754,
-0.010067082,
-0.00022764654,
-0.010598326,
0.010810824,
-0.01470219,
0.020585721,
-0.038169913,
-0.025659107,
-0.013168221,
-0.002007108,
-0.009980755,
-0.0018045709,
-0.017106071,
0.006985864,
0.0049073705,
0.009947552,
0.013706107,
0.017531067,
0.002571555,
-0.03718711,
-0.048847925,
-0.0002008768,
-0.017956061,
0.029802812,
0.019456828,
-0.0115612075,
-0.028607514,
-0.021010717,
-0.0332559,
-0.028341891,
0.037930854,
0.027305964,
0.0107577,
0.016322486,
-0.0060196635,
-0.0012152216,
-0.010345985,
0.03203404,
-0.0016725899,
-0.01614983,
0.017305287,
0.004435891,
0.035327755,
0.011249101,
-0.023002883,
0.0051630316,
0.03200748,
-0.011773705,
-0.022073206,
0.020213852,
0.020373223,
0.038090225,
-0.012371355,
0.020120883,
0.010943635,
0.0232021,
0.02569895,
-0.025845041,
-0.005202875,
0.0033335588,
0.012092452,
-0.031130925,
0.016362328,
-0.034212142,
-0.0006760915,
-0.006564189,
-0.039869893,
-0.032724656,
0.025194267,
-0.02043963,
0.020944312,
0.0030513352,
0.017584192,
0.020944312,
0.023414599,
-0.0075038276,
0.007437422,
-0.023520848,
-0.025884885,
-0.0068796156,
-0.008639363,
-0.017863095,
-0.0056577534,
0.000908926,
-0.0038183194,
-0.010857308,
-0.009170607,
0.0027641312,
-0.029935624,
-0.021422433,
0.014423287,
0.015020937,
0.020997437,
-0.014542816,
-0.0067866477,
-0.029245006,
-0.0076897633,
0.016189674,
-0.02858095,
-0.0037120704,
0.028315328,
-0.018726366,
-0.01470219,
0.0115612075,
-0.030519992,
0.009735054,
-0.031848103,
-0.0092303725,
0.17764814,
-0.009449511,
-0.008313975,
0.017796688,
-0.014595941,
-0.026960656,
0.016999822,
0.0031592443,
-0.029696563,
0.01123582,
0.011348709,
-0.008626082,
-0.023693502,
0.003914607,
0.012085811,
-0.009210451,
-0.022750543,
-0.0050501423,
-0.00859952,
0.024344277,
0.014808439,
-0.02272398,
-0.028607514,
-0.005847009,
0.027093466,
0.004396048,
-0.05044166,
0.009542478,
-0.0033866833,
0.036629304,
-0.014901406,
0.0053688893,
0.003038054,
0.015738117,
-0.011348709,
0.0062952465,
-0.00012087886,
-0.0021814224,
0.003981013,
-0.007942105,
-0.008068275,
0.015525619,
0.0076565603,
-0.028235642,
0.022391953,
0.03285747,
0.0013223006,
-0.012656898,
-0.021143528,
0.008891704,
-0.027545024,
0.018248247,
-0.0015646808,
0.03182154,
-0.0017680479,
-0.008221008,
0.015751397,
-0.005700917,
0.0029550472,
0.020466192,
-0.017717002,
-0.006062827,
-0.029484067,
-0.0045222184,
-0.01949667,
0.03200748,
-0.01600374,
0.00008082801,
0.022418516,
-0.029138757,
-0.0017298647,
-0.007165159,
-0.02522083,
-0.0032488918,
0.0046351077,
-0.0061292327,
0.048661992,
0.02211305,
0.024291152,
0.013201424,
0.008632722,
-0.0134272035,
-0.025685668,
-0.0019390422,
0.025194267,
-0.02844814,
0.04040114,
0.0077030445,
-0.004472414,
-0.014330318,
-0.00028243114,
-0.007928823,
-0.019138081,
-0.0009255274,
0.0023872796,
-0.02284351,
-0.010751059,
0.01124246,
-0.013234627,
-0.016229518,
-0.027359089,
0.054558802,
0.00764992,
-0.0033501603,
-0.010153409,
-0.0071186754,
-0.0061259125,
0.013287751,
0.0042532757,
-0.01326119,
0.010060442,
-0.019589638,
0.01852715,
-0.007603436,
0.011541286,
0.025141142,
0.013247908,
-0.04098551,
0.031715292,
0.003931209,
-0.019350579,
-0.029829375,
0.0020768337,
0.008924906,
-0.021820866,
-0.00932998,
-0.038329285,
0.0074108597,
-0.013772512,
-0.0019324017,
-0.010817464,
-0.005119868,
0.017982624,
0.012690102,
0.015990458,
-0.037346482,
0.025393484,
0.005093306,
-0.008154602,
0.006600712,
0.0062720045,
-0.006886256,
0.008712409,
0.011620972,
0.00092967774,
0.008486629,
0.0046085455,
0.028952822,
-0.021913832,
0.001028456,
-0.00023926751,
-0.009994036,
0.014954531,
0.005524942,
0.008559676,
-0.0034829713,
-0.013161581,
-0.055090047,
-0.013227986,
0.008533114,
-0.043083925,
0.009037796,
0.027359089,
0.020147445,
-0.0062222006,
0.019988071,
-0.1667045,
0.006345051,
0.012152216,
-0.0003814169,
0.031848103,
0.024530211,
0.01685373,
0.017557628,
-0.0016825508,
0.016906854,
0.014184226,
0.011342069,
-0.024570055,
-0.012643618,
0.0063981754,
-0.01591077,
0.00037353125,
0.03453089,
0.01734513,
-0.0120061245,
0.005773963,
-0.03455745,
0.04518234,
0.008267491,
0.011979562,
0.022245862,
-0.010087004,
-0.008300695,
0.022179455,
-0.042047996,
-0.006348371,
-0.0047015133,
0.02474271,
-0.005597988,
-0.010259658,
-0.009077639,
-0.015206872,
-0.0055780667,
-0.018434182,
0.010790902,
0.022657575,
0.025513014,
-0.006740164,
-0.016043581,
0.016588107,
0.022285704,
0.008944828,
-0.036788676,
0.005415373,
-0.00992099,
0.007112035,
-0.007742888,
-0.009522556,
-0.013945166,
0.0033999644,
-0.005345647,
-0.011680737,
0.0029982107,
0.007988588,
0.0055481843,
-0.02463646,
-0.0068331314,
0.0464042,
0.0017995905,
-0.008274132,
-0.027943457,
-0.015206872,
0.016574826,
-0.016641231,
0.009615525,
-0.002546653,
-0.0023623777,
0.019642763,
-0.02317554,
0.026788,
0.017172476,
0.012231903,
0.023467723,
0.011461599,
0.00992099,
-0.01541937,
0.021820866,
-0.021316184,
-0.028527826,
-0.005833728,
-0.0075835143,
-0.009814741,
0.02128962,
0.014502973,
-0.012231903,
0.005189594,
-0.0035427364,
0.004000935,
-0.017849812,
0.030094998,
0.0088053765,
0.0001022023,
-0.023255225,
-0.0011264043,
-0.01757091,
0.011986203,
-0.019177925,
-0.015193591,
0.01159441,
0.027571587,
-0.0036987893,
-0.014449849,
-0.0099077085,
0.05293851,
-0.006232161,
-0.022099769,
-0.016959978,
0.0011288944,
0.017119352,
-0.013719387,
0.053576,
0.0053522876,
0.006122592,
0.0034331672,
-0.02272398,
0.076074205,
-0.010153409,
-0.012842834,
0.017823251,
0.0044060084,
-0.020333381,
-0.13376735,
-0.010511999,
-0.0049804165,
0.022777105,
-0.007928823,
0.029935624,
-0.007782731,
0.02272398,
0.012052608,
0.030546555,
-0.017703721,
-0.007371017,
-0.009183888,
-0.012138936,
-0.000004947992,
-0.0059366566,
0.0027906934,
-0.03168873,
-0.005969859,
0.03049343,
0.0062122396,
-0.015246715,
-0.017770126,
-0.0072050025,
0.0072382055,
-0.004817723,
-0.02953719,
0.013706107,
-0.006358332,
0.016574826,
-0.0012268426,
-0.012524088,
-0.012636977,
-0.020984156,
-0.007756169,
-0.018102154,
-0.0110100405,
-0.023374755,
0.021010717,
-0.014808439,
-0.014516254,
0.020253694,
0.03333559,
-0.0016551585,
0.017796688,
-0.0077893715,
0.0026612026,
-0.0037485936,
0.007271408,
-0.00645462,
-0.014569378,
0.008898344,
-0.03229966,
-0.030626241,
0.024012249,
-0.017902937,
0.016720919,
-0.008685847,
-0.012012765,
0.0059466176,
0.007019067,
-0.0013239607,
-0.018195122,
0.00274753,
0.0019539834,
-0.023932561,
-0.009064358,
-0.002704366,
0.01529984,
-0.009369824,
-0.005534903,
0.018288089,
-0.019430265,
0.00041918506,
-0.032087162,
0.018221684,
-0.013799074,
-0.01948339,
0.002186403,
-0.0013472027,
-0.0054817786,
-0.016681075,
0.011667456,
-0.023215381,
0.026880968,
0.007756169,
-0.012949083,
0.0066704378,
0.00502026,
0.0036257433,
-0.014330318,
0.051822893,
-0.006600712,
-0.010505359,
-0.017384974,
0.035566814,
-0.0054352945,
-0.007450703,
0.013958448,
0.0232021,
-0.032219976,
-0.002282691,
-0.035566814,
-0.0008582918,
0.009628805,
-0.008267491,
-0.00034219612,
-0.0001421494,
0.014556098,
-0.011773705,
-0.02332163,
0.009940911,
-0.018713085,
0.019204486,
-0.030891864,
-0.016216237,
-0.044704217,
0.0033169575,
0.018952146,
-0.0095690405,
0.009994036,
0.018221684,
0.011375272,
0.006726883,
0.023016166,
0.017159196,
-0.0033036764,
0.0134471245,
-0.015724836,
0.0054319743,
-0.0043329624,
-0.017172476,
0.0074042194,
-0.01494125,
-0.016335767,
0.0045122574,
-0.00298659,
-0.011335428,
0.0022179454,
0.020784939,
0.022870073,
0.030865302,
-0.001206921,
-0.021767741,
0.0027325887,
-0.00021135643,
0.016123269,
0.011627613,
-0.022644294,
0.011195976,
-0.0008798736,
-0.020638846,
0.027173152,
0.019071676,
-0.0045222184,
-0.020134164,
-0.009715132,
-0.015963895,
-0.023414599,
0.007796012,
0.02139587,
-0.023613814,
0.013287751,
0.033282463,
-0.0059333364,
-0.025659107,
0.0055614654,
-0.013055332,
-0.023560692,
-0.010113566,
-0.0066571566,
-0.024410682,
-0.011302225,
0.017650597,
0.009668649,
0.01171394,
-0.025871605,
0.00549506,
-0.0066803987,
0.009336621,
-0.020134164,
0.009263575,
0.00322731,
-0.008931547,
-0.009303418,
0.020851344,
0.046218265,
-0.0044159694,
-0.0053024837,
0.041038632,
-0.010133487,
0.008300695,
-0.014449849,
0.0076100766,
0.0057274792,
0.010837386,
0.004565382,
0.010465516,
-0.016415453,
0.014967812,
0.015977176,
0.0034398078,
-0.0039378493,
-0.008586238,
0.00025420878,
-0.018859178,
-0.0056013083,
0.018474026,
-0.019058393,
-0.040693324,
0.008240929,
0.0074042194,
0.015246715,
0.00788898,
0.016920134,
0.00081139285,
-0.030307496,
0.0095624,
-0.018155279,
-0.01985526,
-0.01948339,
0.03739961,
0.013692825,
0.032485597,
0.0007624188,
-0.009662008,
0.009735054,
-0.0017780088,
0.013579936,
-0.022338828,
0.013174862,
0.0047413567,
0.03285747,
0.016840449,
-0.021807585,
-0.013613138,
-0.02725284,
-0.007895621,
0.0007703044,
0.0063085277,
-0.006179037,
0.082342885,
0.0072514866,
-0.03490276,
0.0007781901,
-0.001327281,
0.02186071,
0.017849812,
0.003921248,
-0.01840762,
-0.035407443,
0.016335767,
0.00004806621,
0.023866156,
-0.027359089,
-0.0071385973,
0.030466868,
-0.008798736,
0.020134164,
-0.008499911,
-0.018460745,
0.011879954,
-0.04146363,
-0.01230495,
0.017384974,
-0.014755314,
0.0018477346,
0.023906,
0.015870927,
-0.0014576019,
0.003911287,
0.010684654,
-0.026455972,
-0.035407443,
0.013520171,
-0.009157326,
0.014874844,
-0.005438615,
-0.011813548,
0.031024676,
0.0023972406,
0.018221684,
-0.014277195,
0.0001953776,
0.0160303,
-0.0029434261,
-0.0046683103,
0.008851861,
-0.0094627915,
-0.0058968132
] |
Leukemias and other cancers possess self-renewing stem cells that help to maintain the cancer. Cancer stem cell eradication is thought to be crucial for successful anticancer therapy. Using an acute myeloid leukemia (AML) model induced by the leukemia-associated monocytic leukemia zinc finger (MOZ)-TIF2 fusion protein, we show here that AML can be cured by the ablation of leukemia stem cells. The MOZ fusion proteins MOZ-TIF2 and MOZ-CBP interacted with the transcription factor PU.1 to stimulate the expression of macrophage colony–stimulating factor receptor (CSF1R, also | [
-0.014955239,
-0.0010074291,
0.004399961,
-0.029857585,
-0.014717225,
0.03083609,
-0.017110592,
-0.0035007955,
-0.026036132,
-0.0044892165,
0.021487413,
0.017718852,
0.0230874,
0.0059206085,
-0.027318766,
-0.0073850583,
0.02694852,
-0.0035536874,
-0.023695657,
0.0053520184,
-0.034802996,
0.010128835,
-0.007900756,
-0.019054376,
0.009216447,
0.006981756,
0.00866108,
-0.037368264,
-0.0031090633,
-0.012231296,
0.027609672,
0.0124428645,
-0.00857513,
-0.0036330256,
-0.020561801,
0.000103201564,
0.022148564,
-0.01635688,
0.022558477,
-0.009619749,
0.012866002,
0.019953541,
0.001685109,
0.006066062,
-0.01609242,
-0.012489146,
-0.00017169269,
0.0014429624,
-0.0034545148,
0.008277613,
0.020138664,
-0.0045354967,
-0.0056892056,
0.0059768064,
-0.02996337,
-0.024660937,
-0.00005330531,
0.041176494,
-0.002029734,
-0.004479299,
0.000018969356,
0.0083900085,
-0.0113255195,
0.012826332,
0.004409878,
0.023629542,
-0.0074643963,
0.010023052,
0.0062941588,
0.0037189752,
0.045434307,
0.011669318,
0.0013627978,
-0.005828047,
0.0063139936,
-0.011861051,
-0.0245816,
0.012165181,
0.0013396575,
-0.00078470376,
0.028852636,
-0.009170166,
-0.022994837,
0.00546772,
0.016475886,
-0.0037421156,
0.01732216,
0.007629684,
0.0076561305,
0.007966871,
0.0058313534,
0.016806463,
0.019503959,
0.017877527,
-0.008079267,
0.026485715,
0.006783411,
0.0037850903,
0.011960224,
-0.03162947,
-0.0139106205,
0.00030474935,
-0.0060958136,
-0.018816361,
-0.02353698,
-0.0065487023,
0.015669283,
-0.0019834535,
0.015775066,
0.003370218,
-0.02602291,
0.032687314,
0.02571878,
-0.05432018,
0.038875688,
-0.02117006,
-0.00057850726,
0.0030776586,
-0.027001413,
0.012839556,
0.023589874,
0.032343514,
0.005100781,
-0.023484088,
0.0108891595,
0.017784966,
-0.024660937,
-0.017811412,
-0.018181657,
0.000110639514,
0.030122047,
0.014307311,
0.0063668857,
0.0054908604,
-0.01779819,
0.017361829,
-0.016912246,
-0.026102247,
-0.03832032,
-0.023259297,
-0.009771814,
0.03371871,
0.008938763,
0.005659454,
-0.0022908887,
0.0044032666,
0.01758662,
-0.014902347,
0.019490736,
0.0071668783,
0.004224756,
-0.027080752,
0.012105677,
-0.0062842416,
0.008826368,
-0.012165181,
0.0010140406,
0.038346767,
-0.028667513,
-0.021143613,
-0.008085879,
-0.025441097,
0.017295714,
0.008621411,
0.009837929,
0.03530547,
0.0011851134,
0.0065982887,
-0.015907297,
-0.009176778,
0.013163519,
0.02961957,
-0.019874204,
0.014413095,
-0.028138593,
0.010611476,
-0.012813109,
0.037950076,
-0.029275773,
-0.020151887,
-0.011014778,
0.027027858,
0.009223059,
0.010089166,
-0.0047569824,
-0.0018991567,
0.028482392,
-0.029857585,
0.0050511947,
-0.013064347,
-0.0041718637,
0.013269303,
0.007186713,
-0.012958563,
-0.63343567,
-0.035279024,
0.004816486,
0.014413095,
0.0107437065,
0.025652664,
0.0057222634,
-0.030677414,
-0.03657488,
0.012780052,
-0.0030941875,
0.00782803,
-0.004274342,
-0.020998161,
-0.009381735,
-0.027927024,
-0.029936925,
-0.017732074,
0.017811412,
0.0060693678,
-0.012085843,
0.0048330147,
-0.009302396,
0.008185051,
-0.0025470848,
0.0038115364,
0.026498938,
-0.026446046,
-0.00590408,
0.027371658,
-0.03459143,
0.025163412,
-0.011907333,
0.017507283,
0.052389618,
0.010208174,
0.0018181656,
0.016502332,
0.003910709,
0.023457643,
0.014611441,
0.0084429,
0.03898147,
-0.00605945,
-0.017308937,
0.010128835,
0.002302459,
0.024079125,
0.006198292,
-0.0069751446,
0.009857764,
0.00054421,
-0.02681629,
-0.01150403,
0.02217501,
0.0152197,
0.037288927,
-0.031682365,
0.009216447,
-0.0029470813,
-0.0065321736,
0.009679253,
-0.008026375,
-0.006026393,
0.0020694032,
0.010095778,
-0.01574862,
0.008132159,
0.008978433,
-0.0106709795,
0.016674232,
0.014227972,
-0.0120660085,
0.0152329225,
0.007947037,
0.036257528,
-0.013672606,
-0.008859426,
-0.0026065884,
-0.016171757,
0.013818059,
-0.018300664,
-0.003993353,
-0.0041718637,
0.018829584,
-0.0048429323,
-0.016409772,
0.008416454,
0.0067239073,
0.011378411,
-0.0045354967,
-0.0039834357,
-0.020403124,
-0.05104087,
-0.020561801,
0.0207337,
-0.010505692,
-0.0032231119,
0.029275773,
-0.02961957,
-0.026327038,
-0.029275773,
0.025441097,
-0.005616479,
0.002434689,
-0.0018611405,
-0.02165931,
-0.01893537,
0.035041012,
-0.026908852,
-0.0024974984,
0.007113986,
0.008951986,
-0.0054379683,
0.0095668575,
-0.018260995,
-0.0022892358,
0.020918822,
-0.010023052,
-0.028482392,
0.011530476,
0.016224649,
0.0075834035,
0.0012884183,
0.019080821,
0.0005702429,
0.014333757,
-0.012237907,
-0.0027570003,
-0.027345212,
-0.007120598,
-0.0043503745,
0.004475993,
-0.028429499,
0.026393155,
-0.008713972,
0.0026594806,
-0.007662742,
0.035913732,
-0.01478334,
-0.03284599,
-0.015074247,
0.007133821,
-0.009037936,
-0.0012297411,
-0.0047536767,
-0.00454872,
-0.004509051,
0.008409843,
-0.0361253,
0.020482462,
-0.010181728,
-0.017375052,
0.016727123,
0.009077605,
-0.011028001,
0.0061487057,
-0.021156836,
-0.008852814,
-0.031523686,
-0.016343657,
0.014756894,
0.008191663,
0.0066677094,
0.0046115294,
-0.009070993,
-0.0034809608,
0.0061487057,
-0.015642837,
-0.030280722,
0.0027735292,
-0.02130229,
-0.033163343,
-0.008343727,
0.0025140273,
0.0014115577,
-0.02230724,
0.00054421,
-0.0102346195,
-0.0152197,
0.004254508,
-0.00892554,
0.019768419,
-0.0024446063,
0.023417974,
0.015801512,
0.020482462,
0.0022710543,
0.0020677503,
0.015391598,
-0.018922146,
0.015153584,
-0.016118865,
0.0041883923,
0.009163555,
0.0007590842,
-0.005956972,
0.02095849,
0.012872613,
0.03189393,
-0.006390026,
-0.011292461,
0.01662134,
-0.01635688,
0.010512304,
-0.026313815,
-0.012264354,
-0.030412953,
0.020363456,
0.01802298,
0.00075495197,
-0.005993335,
-0.033692263,
0.013236246,
0.01592052,
0.0027222899,
0.020575024,
-0.009864375,
-0.0013380046,
-0.0022363437,
-0.0075900154,
0.009388346,
-0.0034941838,
-0.030174939,
0.015894074,
0.021936996,
0.029011313,
0.018181657,
0.0007859434,
0.0014504003,
0.005970195,
0.011596591,
0.01434698,
0.01644944,
0.010181728,
0.0045817774,
0.035675716,
-0.0032908798,
0.046809502,
-0.020905599,
-0.013923843,
0.007966871,
-0.001988412,
0.022637816,
-0.006155317,
-0.002856173,
0.03250219,
0.008403231,
-0.014148635,
0.029593125,
-0.044508696,
0.027186535,
-0.011841217,
-0.0055834213,
0.0036892234,
-0.0118478285,
0.0027107198,
0.010181728,
0.02598324,
0.015113915,
0.011550311,
-0.011087505,
-0.014175081,
-0.012046174,
-0.012594929,
-0.0020793204,
0.020575024,
-0.019477513,
-0.0039602956,
0.0132098,
-0.035675716,
-0.001190072,
0.013170131,
-0.035041012,
-0.00028801398,
0.023166737,
0.00024875812,
0.0068561374,
0.026578275,
0.0044462415,
-0.0009884209,
-0.030809643,
0.032052606,
0.0095668575,
-0.015841182,
-0.032660868,
-0.026168363,
-0.0072462168,
0.019239498,
0.009943713,
0.020918822,
0.024568377,
0.00056982966,
0.012826332,
-0.02484606,
-0.015510606,
0.013051123,
-0.001082635,
0.015669283,
0.007080929,
-0.018882478,
-0.009983382,
-0.013870951,
-0.0064065545,
0.020032879,
0.006631346,
0.013527152,
-0.024383254,
-0.00601317,
-0.033163343,
0.0019421316,
-0.022201456,
0.013183354,
-0.020323787,
0.001583457,
-0.0100164395,
0.009018102,
0.00809249,
0.0042611193,
-0.01749406,
-0.009110663,
-0.01815521,
0.02247914,
0.001948743,
0.03718314,
0.031417903,
-0.012965174,
0.010763541,
0.00422145,
-0.0039966586,
0.004479299,
-0.03898147,
0.021381628,
-0.009302396,
-0.0054710256,
0.026631169,
-0.0033950112,
-0.0073718354,
0.011054447,
0.04167897,
-0.0017619678,
-0.013051123,
-0.020403124,
-0.011100728,
0.010823044,
-0.01115362,
0.041308723,
0.03250219,
0.017044477,
0.0063503566,
-0.012032951,
0.020019656,
0.0043371515,
-0.009223059,
-0.010214785,
0.004737148,
-0.0048330147,
0.010968498,
-0.006687544,
-0.036151744,
0.025057629,
0.00058057334,
0.006132177,
-0.017970089,
0.0069883675,
0.013130462,
0.00067685347,
0.0040826085,
-0.017507283,
-0.009553635,
0.011867663,
0.008700749,
-0.009355289,
-0.031603023,
0.037500493,
-0.024290694,
-0.018446118,
-0.011431304,
0.028879082,
0.004885907,
-0.013989958,
-0.0065354793,
-0.006687544,
-0.0026842738,
0.0053024325,
-0.03350714,
0.004274342,
-0.0035437702,
-0.004254508,
-0.01434698,
0.022532031,
0.0077222455,
-0.031920377,
-0.01207262,
0.02602291,
-0.01272716,
-0.026882406,
0.015285814,
0.014095742,
0.016317211,
0.031259228,
0.0024115487,
-0.021897325,
0.021341959,
-0.00024276644,
-0.0042842594,
-0.0029553457,
-0.047126856,
0.005533835,
0.0059073856,
0.015312261,
-0.011292461,
-0.026538607,
0.014439541,
0.007160267,
0.015603167,
0.0262477,
0.005004914,
-0.010313958,
0.012396584,
0.028455945,
0.013950289,
-0.026313815,
-0.0065255617,
-0.0051536732,
-0.022056002,
-0.031285673,
-0.0001950396,
-0.03165592,
-0.020032879,
0.010789987,
0.005699123,
-0.019226275,
-0.023933671,
0.016634563,
-0.014241196,
-0.0011859399,
-0.0036892234,
0.01919983,
0.0042809537,
0.011232958,
0.010446188,
0.00901149,
0.011424692,
-0.0026049356,
-0.014452764,
0.015801512,
0.027900578,
-0.012766829,
-0.0019553546,
0.0105982525,
-0.0004454506,
0.00031590628,
-0.008727195,
-0.016555225,
0.06854815,
-0.024991514,
-0.020654362,
-0.020720476,
-0.016846132,
0.004955328,
0.01377839,
0.018472563,
-0.014360203,
-0.007662742,
0.016700678,
-0.007927203,
-0.010882548,
0.016819686,
-0.029381556,
-0.0035933566,
0.030174939,
0.0066577923,
-0.019001484,
-0.03559638,
0.014584994,
-0.0048958245,
-0.009004879,
-0.010823044,
-0.02243947,
0.0071668783,
-0.008594965,
0.05109376,
0.029672464,
0.039431054,
-0.0019057682,
0.017903972,
0.0061751516,
0.0038247595,
0.010009828,
-0.009884209,
0.036098853,
-0.012753606,
0.031338565,
0.018975038,
-0.008271001,
0.030730305,
-0.018115541,
0.030809643,
0.028429499,
-0.011034613,
-0.015100692,
0.008786699,
-0.015761843,
-0.050802853,
0.01916016,
-0.026221255,
-0.0030231136,
-0.032978218,
-0.010135448,
0.033084005,
0.006942087,
0.010730484,
0.018684132,
0.028931974,
-0.0042181443,
0.018141987,
-0.0066015944,
0.010908994,
-0.020138664,
-0.0056462307,
-0.003947072,
-0.008985044,
0.017560175,
-0.0036032738,
-0.014320534,
0.018961815,
-0.02694852,
0.003844594,
-0.0014727142,
-0.029143542,
-0.026393155,
-0.017877527,
-0.035014566,
-0.011312297,
0.003356995,
-0.0049454104,
-0.03564927,
-0.00088594254,
-0.0062049036,
-0.010915605,
0.0059239143,
0.006320605,
-0.012813109,
0.05432018,
-0.012918893,
0.015246145,
-0.022584923,
-0.005507389,
0.017269269,
-0.0023834498,
-0.010280901,
-0.003100799,
-0.0009024713,
0.018049426,
0.018988261,
0.03110055,
-0.024660937,
-0.015669283,
0.017745297,
0.018988261,
-0.003573522,
-0.028403053,
0.017996535,
-0.020231225,
0.010657757,
-0.014651109,
-0.028984867,
-0.027450996,
0.0029322053,
-0.0018479174,
0.02598324,
0.0034677377,
-0.0033388133,
-0.038029414,
0.03490878,
0.003639637,
-0.010380073,
-0.013659383,
-0.017903972,
0.002125601,
-0.0064065545,
-0.015629614,
0.0242378,
-0.027450996,
0.059292037,
-0.001948743,
0.0068958066,
0.01561639,
0.002585101,
-0.009342066,
-0.006538785,
0.008449512,
0.033745155,
-0.010267678,
0.014333757,
0.0124428645,
0.010380073,
-0.021011384,
-0.019120492,
-0.010565195,
-0.0016099031,
-0.040647574,
-0.0017884139,
0.028191485,
0.01627754,
-0.013070959,
-0.0037917017,
-0.02581134,
-0.013976735,
-0.0021437826,
-0.015775066,
0.011603203,
-0.0434773,
-0.00003569183,
0.012297411,
0.017679181,
0.010571807,
-0.0109618865,
0.011953613,
-0.007378447,
0.023550203,
-0.023034506,
0.013414756,
0.01299162,
0.005077641,
-0.0046445867,
-0.006942087,
0.015285814,
-0.028879082,
-0.0043801265,
-0.027609672,
-0.034194738,
-0.005114004,
0.0015090775,
0.004155335,
0.0103073465,
-0.017467614,
0.0074048927,
0.010644534,
0.015312261,
-0.0005966889,
-0.008423066,
0.022122117,
-0.02598324,
0.0039173206,
0.026882406,
-0.02086593,
-0.021593196,
0.010915605,
0.010221397,
0.011318908,
-0.0015470937,
-0.021341959,
-0.009599915,
-0.0050545004,
-0.013018066,
-0.002408243,
0.005947055,
-0.009249505,
-0.0076825763,
-0.0071536554,
0.0061751516,
-0.008509016,
-0.009976771,
-0.006783411,
-0.0031024518,
0.0014330451,
-0.03482944,
0.015061024,
-0.020138664,
-0.020799816,
-0.028085701,
0.0036098852,
-0.032211285,
0.01819488,
-0.0007937946,
0.0017388276,
-0.013923843,
0.0031041047,
-0.045831,
-0.019279167,
0.002775182,
0.012945339,
0.007080929,
0.015550275,
-0.0075371233,
0.0012041215,
-0.004165252,
0.01806265,
0.00089833915,
-0.012680879,
0.015193254,
0.003006585,
0.015312261,
-0.010571807,
-0.039536837,
-0.0023784912,
0.017639512,
-0.012826332,
-0.007814807,
0.019530404,
-0.018141987,
0.01290567,
0.012502369,
0.018340332,
0.0039173206,
0.01290567,
0.005451191,
-0.008581742,
0.0037454213,
0.016409772,
0.012317246,
0.00009886276,
-0.006796634,
-0.00050412776,
0.006968533,
0.0066677094,
-0.0009818095,
-0.012052786,
0.009666029,
-0.011530476,
0.021328736,
0.005619785,
0.00717349,
0.010399908,
-0.009599915,
0.013540376,
-0.007067706,
-0.0008570172,
-0.0036627774,
-0.020575024,
0.012700713,
0.0042809537,
-0.022981614,
-0.0018627933,
-0.006902418,
-0.011788325,
0.0054809432,
-0.0022975001,
-0.014598218,
-0.034036063,
0.022756822,
-0.015378376,
-0.014241196,
-0.0067602703,
0.011166843,
-0.02314029,
-0.026393155,
-0.010862714,
0.010505692,
-0.011444527,
-0.017705629,
-0.0032743511,
-0.005332184,
-0.007299109,
0.01565606,
0.0055470583,
0.008581742,
0.014664332,
0.21378984,
-0.030888982,
-0.0070743174,
-0.00010103216,
-0.007781749,
-0.011576757,
0.020204779,
-0.0049057417,
-0.009844541,
0.019345284,
0.013540376,
-0.00813877,
-0.015404821,
-0.007484231,
0.004317317,
-0.006442918,
-0.019186607,
-0.0009933796,
-0.031946823,
-0.026604723,
0.008085879,
0.0023900615,
0.029037759,
-0.0058115185,
0.0075040655,
0.0012661044,
-0.0036198027,
0.010631311,
0.016330434,
-0.011550311,
-0.026128694,
0.02768901,
-0.010201562,
0.013176742,
0.0049057417,
-0.004046245,
-0.0172296,
-0.010142059,
0.025930349,
-0.000027840662,
0.004304094,
-0.0043470687,
-0.02651216,
0.014770117,
0.0056892056,
0.023391528,
-0.012766829,
0.0035437702,
0.009983382,
-0.001387591,
-0.04588389,
0.008171828,
0.00095205766,
0.018049426,
0.005540447,
0.0014247807,
0.028641067,
0.013302362,
0.0030115435,
0.026736952,
0.0020908904,
-0.00080536475,
-0.030888982,
0.01644944,
-0.005047889,
0.015801512,
-0.015854405,
0.0088395905,
0.035887286,
0.00017272573,
-0.007444562,
-0.029037759,
0.01246931,
0.0007661089,
-0.0012537079,
-0.035622824,
0.003547076,
0.015312261,
0.015497383,
0.00874703,
0.014558548,
-0.0067338245,
-0.018221326,
0.009553635,
0.003330549,
-0.018975038,
0.014241196,
0.02147419,
-0.015404821,
-0.019768419,
0.00029545193,
-0.017282492,
-0.002166923,
0.010175116,
0.0117023755,
0.015418045,
-0.00038945934,
0.022056002,
0.009970159,
-0.013269303,
-0.03958973,
0.050406165,
0.00091569434,
0.019041153,
0.0055668927,
0.0047569824,
-0.0031371622,
-0.006135483,
-0.009342066,
0.010228008,
0.021328736,
-0.0152197,
0.0076561305,
-0.0066908496,
0.0052396227,
0.016846132,
0.0032693925,
-0.021593196,
0.0461748,
-0.011748656,
-0.003814842,
-0.031735256,
0.005804907,
0.026089024,
-0.00887926,
0.015761843,
-0.043054163,
-0.008204886,
-0.03250219,
-0.021143613,
-0.011880886,
0.02042957,
0.0050511947,
0.021553528,
-0.00468095,
-0.0128792245,
-0.00739167,
-0.011147008,
-0.03170881,
0.006373497,
-0.009335455,
0.0021322125,
-0.005682594,
0.020310564,
-0.0018297358,
-0.01793042,
0.016581671,
0.010181728,
-0.017256046,
-0.020852707,
-0.016198203,
-0.02628737,
-0.018922146,
-0.017639512,
0.009176778,
-0.03564927,
-0.015497383,
-0.03406251,
-0.0055040834,
0.020561801,
-0.03284599,
0.022241125,
-0.005606562,
-0.00958008,
0.0065817595,
-0.0059206085,
-0.16618696,
0.00066776265,
0.014584994,
-0.016171757,
0.028244378,
0.010380073,
-0.0006747874,
-0.021103945,
0.0001994817,
0.0031189804,
0.028852636,
-0.005573504,
-0.05043261,
-0.012813109,
0.0037288924,
-0.000056559416,
-0.01189411,
0.028455945,
0.03437986,
0.0130246775,
0.0013892439,
-0.012403196,
0.01990065,
-0.0072329934,
0.0058412706,
-0.009996605,
0.018657686,
-0.021236176,
-0.019213052,
-0.021844434,
-0.0043768208,
-0.008376785,
0.0084429,
-0.014889124,
0.013064347,
0.0090577705,
-0.013870951,
0.00787431,
0.02209567,
0.023946894,
0.019768419,
0.0077024107,
0.0018231242,
0.011623037,
-0.0052396227,
0.056964785,
0.001314038,
-0.012634599,
0.0172296,
0.00049751624,
0.02803281,
-0.013057735,
-0.010036275,
0.019252721,
0.0042412844,
0.0071007633,
-0.000632639,
0.0015380029,
0.020495685,
0.0033784823,
-0.010842879,
-0.010399908,
0.018684132,
0.0060858964,
0.0059900293,
-0.014042851,
-0.005937137,
0.022677485,
-0.028905528,
0.0047107018,
-0.019979987,
0.0037024464,
0.010287512,
-0.0070875403,
0.024568377,
0.01565606,
-0.0019057682,
-0.0005644578,
0.020971714,
0.012753606,
-0.012594929,
0.023417974,
-0.016489109,
-0.008588353,
-0.0026991495,
0.0040627737,
0.010479245,
0.0024132016,
-0.018036203,
-0.020204779,
-0.0036164967,
-0.022413025,
-0.008429677,
-0.0011272627,
0.014889124,
0.03451209,
-0.018922146,
-0.0063139936,
0.00016725058,
0.01592052,
0.01990065,
-0.0152197,
-0.026036132,
-0.0028462557,
0.04133517,
-0.01185444,
-0.009606526,
0.0031917072,
0.02996337,
-0.0042280615,
-0.0023553509,
0.02016511,
0.008013152,
0.008343727,
0.014756894,
0.0055470583,
0.021778319,
-0.007966871,
0.0011338742,
-0.01902793,
0.06574487,
-0.007133821,
-0.016489109,
0.022148564,
-0.01233708,
-0.011755267,
-0.12704681,
-0.018697355,
-0.0055999504,
0.008284224,
-0.027768347,
0.024079125,
-0.0042578136,
0.015854405,
-0.031126997,
0.025044406,
-0.028455945,
-0.024555154,
0.0030594768,
-0.00848918,
0.009831318,
-0.0010570154,
-0.007695799,
-0.006661098,
-0.047840897,
0.03371871,
0.0052297055,
0.008475957,
-0.00457186,
-0.02755678,
0.037421156,
0.020786593,
-0.032396406,
0.033692263,
0.018128764,
0.018472563,
0.01574862,
-0.014902347,
0.02698819,
0.00020929566,
-0.009209836,
0.007047871,
0.006902418,
-0.025758449,
0.031206334,
-0.022518808,
-0.011173454,
0.016859354,
0.0055933385,
-0.03459143,
0.02209567,
-0.015603167,
-0.017546952,
0.011133785,
0.034750104,
-0.015788289,
-0.034406304,
-0.04027733,
-0.02378822,
-0.0027834463,
0.027583227,
-0.010399908,
0.0023503923,
0.028773298,
-0.0225717,
-0.025903903,
0.0170577,
-0.007067706,
0.0022512197,
0.006026393,
0.018036203,
-0.009289173,
0.0034479033,
-0.028852636,
0.012449476,
-0.026379932,
0.009163555,
-0.015775066,
-0.02969891,
-0.0128792245,
-0.014373426,
-0.0022941944,
-0.019543627,
-0.028905528,
0.0041586407,
-0.019384952,
-0.016251095,
-0.005884245,
-0.00043429367,
-0.018604793,
0.028059255,
-0.0060561444,
0.0040131877,
-0.013408145,
-0.004069385,
-0.013070959,
0.007947037,
0.03284599,
-0.014651109,
-0.030148493,
-0.0036859177,
0.015788289,
0.0074511734,
-0.0139106205,
0.015312261,
0.040065758,
-0.0019818007,
-0.020204779,
-0.059503604,
0.019239498,
-0.015722174,
-0.018644463,
0.0051106983,
-0.0063404394,
0.006608206,
-0.0076230727,
0.009738756,
0.017917195,
0.0022727072,
0.0014743671,
-0.013606491,
0.010975109,
-0.010512304,
-0.0071272096,
0.031470794,
-0.007920591,
0.018221326,
0.009619749,
0.0047966517,
0.0011751961,
0.00901149,
0.01150403,
-0.00796026,
0.012356915,
-0.0071668783,
0.04675661,
0.0007532991,
-0.00023284917,
-0.00013470955,
-0.04247235,
-0.0052462346,
-0.011517253,
0.002408243,
-0.016608117,
0.0042478964,
0.027821241,
0.008819756,
0.030307168,
0.012885836,
-0.021117168,
0.016502332,
0.010538749,
-0.007993317,
0.0118478285,
-0.01980809,
0.033004664,
0.006171846,
0.0050511947,
0.031603023,
0.0016148617,
0.0023338636,
-0.033533588,
-0.019741973,
0.00058057334,
0.0188957,
-0.008733807,
-0.025203083,
-0.0032313762,
0.017718852,
0.031179888,
-0.0034611262,
-0.008938763,
-0.032793097,
-0.00043842586,
-0.01627754,
-0.0003142534,
-0.008654469,
-0.019173384,
-0.018340332,
0.0056925113,
-0.006105731,
0.0012685838,
0.02120973,
-0.0011917249,
-0.023748549,
0.0077619143,
-0.0029305525,
0.020231225,
-0.0066908496,
-0.008872649,
-0.0019272557,
-0.00076280313,
0.020442793,
-0.003626414,
-0.016965138,
0.032634422,
-0.0147965625,
-0.027794795,
0.0035007955,
0.013738721,
0.01582796,
0.0147965625,
0.016475886,
0.013659383,
0.0045685545,
-0.000785117,
-0.00032003847,
0.032528635,
-0.0042016157,
-0.016819686,
0.0040660794,
-0.022161787,
-0.0070544826,
0.021844434,
-0.04955989,
-0.036283974,
-0.0121387355,
0.008773476,
0.028852636,
0.021685759,
-0.017137038,
-0.0013809794,
-0.009249505,
0.009123886,
-0.007894144,
-0.018789915,
-0.014175081,
0.04461448,
0.026736952,
0.009414792,
0.018604793,
-0.0041586407,
0.0015884156,
0.0122908,
0.017613066,
-0.01609242,
0.03961618,
-0.014611441,
0.024700606,
0.014479211,
-0.050379716,
-0.011180066,
-0.006075979,
-0.008284224,
0.032872435,
0.0097850375,
-0.008323893,
0.08282901,
0.0061949864,
-0.031047657,
0.010353627,
-0.026750175,
0.013322196,
0.019570075,
0.022783268,
0.005037972,
-0.023365082,
0.024594823,
-0.032079052,
0.020826261,
-0.02956668,
-0.017467614,
0.007629684,
0.0034346802,
0.0015760191,
-0.0009570163,
-0.013104016,
0.007431339,
0.0061288713,
-0.005917303,
0.009573469,
-0.03773851,
-0.0075900154,
0.029011313,
-0.012515591,
0.017507283,
-0.023933671,
-0.0041487236,
-0.018975038,
-0.028614622,
-0.026763398,
0.02378822,
-0.008052821,
-0.0076032383,
-0.041176494,
0.015259368,
0.03559638,
-0.019530404,
0.027450996,
-0.0008570172,
-0.01548416,
0.0031652611,
-0.01679324,
0.0052594575,
-0.02685596,
-0.0033288961
] |
Acute skeletal muscle injury triggers an expansion of fibro/adipogenic progenitors (FAPs) and a transient stage of fibrogenesis characterized by extracellular matrix deposition. While the perpetuation of such phase can lead to permanent tissue scarring, the consequences of its suppression remain to be studied. Using a model of acute muscle damage we were able to determine that pharmacological inhibition of FAP expansion by Nilotinib, a tyrosine kinase inhibitor with potent antifibrotic activity, exerts a detrimental effect on myogenesis during regeneration. We found that Nilotinib inhibits the damage-induced expansion of satellite | [
-0.02523733,
-0.016829377,
0.0014308003,
-0.045138843,
-0.05306172,
0.023310507,
-0.043144647,
0.016721584,
-0.015225938,
-0.0020666178,
0.02287933,
0.01145314,
0.022852382,
0.014767813,
-0.0062284865,
-0.019241273,
0.032553863,
-0.008967134,
-0.019632028,
0.0091423,
-0.0060331095,
0.031206436,
0.002155885,
-0.0057669925,
-0.011789996,
0.016923698,
0.0022586265,
-0.03802442,
-0.01901221,
-0.0075051747,
0.014727389,
-0.003107506,
0.004224187,
-0.014579172,
-0.00544361,
-0.002900339,
-0.007202003,
-0.021639695,
0.0023495778,
-0.013905458,
0.023593467,
-0.0027959135,
0.008428163,
0.014026727,
-0.008569643,
-0.009546529,
0.007842031,
0.00088846043,
-0.010658156,
0.024536666,
0.014417481,
-0.0032001417,
0.0006762405,
0.020117102,
0.0031883519,
-0.022717638,
0.011251025,
0.016815903,
0.0076466547,
-0.00023264189,
-0.010584048,
0.01312395,
-0.018783148,
-0.00412313,
-0.011055647,
0.016088292,
-0.0076668663,
0.0006644505,
-0.016290406,
-0.010691842,
0.051875982,
0.033038937,
-0.0131778475,
-0.027406689,
0.03037103,
-0.008805443,
-0.006615872,
-0.013534916,
-0.02464446,
0.0074041174,
0.011843894,
-0.023728209,
-0.021262417,
0.036138024,
0.012524345,
-0.015522372,
-0.005888261,
0.018513663,
0.009910334,
0.0011680517,
0.022070874,
0.010536888,
0.008515745,
0.009485894,
-0.031799305,
-0.0020245109,
-0.012106642,
0.0026611707,
-0.012847727,
-0.020440485,
-0.015697537,
0.013891984,
-0.01941644,
-0.016384726,
-0.03206879,
0.021585798,
0.010018128,
-0.0020565123,
0.010664893,
-0.014134521,
-0.024307603,
0.011446402,
-0.0033500432,
-0.047725905,
0.018298075,
-0.017556988,
0.02351262,
0.007040312,
0.009937283,
-0.024819626,
0.019335594,
0.011796733,
0.019281697,
-0.009957494,
0.016438624,
0.0048237927,
-0.00431177,
0.0074378033,
-0.029293088,
-0.00046149414,
0.014673492,
0.003206879,
0.016465573,
0.0020228266,
-0.014902555,
0.02278501,
-0.022434678,
-0.032392174,
-0.03638056,
-0.04724083,
-0.0051168585,
0.01731445,
-0.021545377,
0.01536068,
-0.018500188,
0.01903916,
0.004695787,
0.006090375,
0.02558766,
-0.009364625,
0.01218075,
-0.008360792,
-0.012025796,
-0.00419387,
-0.022569422,
0.008657225,
-0.008650488,
0.004857478,
-0.019429913,
-0.019941937,
0.022165192,
-0.016721584,
0.01425579,
-0.010570574,
0.0011486824,
0.015993971,
0.018149856,
-0.018607983,
0.006177958,
-0.006622609,
0.0010855218,
0.022192141,
-0.023216186,
0.01241655,
-0.015293309,
0.005315604,
-0.013737029,
0.026005363,
-0.032715555,
-0.01800164,
-0.024711832,
0.011021962,
0.036245815,
-0.007431066,
-0.008967134,
0.006248698,
0.027810916,
-0.016654212,
-0.011459876,
-0.029185293,
0.014282738,
0.018419342,
-0.025277752,
-0.012908362,
-0.62305075,
-0.0243615,
0.032688607,
-0.008515745,
0.018122908,
0.032446068,
0.00881218,
-0.017287502,
-0.02033269,
0.00966106,
-0.015751434,
0.024226759,
0.024900472,
-0.019739822,
-0.025345122,
-0.018890942,
-0.016088292,
-0.023714734,
0.0035471045,
-0.0020514594,
0.008219312,
0.0084349,
0.010934379,
0.029320037,
0.021949604,
0.026490437,
0.017813,
0.0041601844,
0.002587062,
0.02926614,
-0.026746448,
0.045704763,
0.0022619949,
0.0044734613,
0.06052647,
-0.0056255125,
-0.0015444895,
0.020251844,
0.006568712,
0.020063205,
-0.012234648,
0.020427011,
0.012450236,
0.007471489,
-0.006642821,
0.01397283,
0.015589744,
-0.009351151,
-0.022717638,
0.0046654698,
0.022771535,
0.020683022,
-0.035491258,
0.021073775,
0.01213359,
0.008778494,
0.014929504,
0.008879552,
0.00086488045,
0.025102586,
0.02322966,
0.028538527,
-0.024024643,
-0.021221993,
0.014902555,
0.012308756,
-0.01649252,
0.010233717,
0.007148106,
-0.019402966,
0.022434678,
0.04327939,
-0.0051370696,
-0.001240476,
0.019120006,
0.03223048,
-0.009445471,
0.004102919,
-0.008165414,
-0.0024792678,
0.0014476432,
0.010934379,
-0.01957813,
0.0027100148,
0.029670367,
0.021720542,
-0.035356514,
0.031395074,
0.0069662035,
0.0025735877,
-0.009714956,
-0.013737029,
-0.015023824,
-0.050851937,
-0.024981318,
0.032473017,
0.008178889,
0.021235468,
-0.01175631,
-0.025762826,
-0.01397283,
0.015023824,
0.015481949,
-0.007565809,
0.029697316,
-0.005736675,
-0.033254527,
0.0050191698,
0.039452694,
-0.042794317,
0.026894666,
-0.0024573721,
-0.008428163,
-0.018688828,
0.009573477,
-0.023566518,
0.0100855,
-0.011358819,
-0.012072956,
-0.026732974,
-0.0031681403,
0.0073636947,
0.0110960705,
0.0163982,
0.03298504,
0.015899653,
0.003307936,
-0.002858232,
-0.0130363675,
-0.010610997,
-0.0008168783,
-0.010442568,
0.039479643,
-0.017772578,
0.027231522,
-0.015993971,
0.016411675,
0.016128715,
0.025331648,
-0.037054274,
-0.025978414,
-0.023175763,
0.00424103,
0.0055008754,
-0.009337677,
-0.014619595,
0.0012244753,
0.009007557,
0.027123729,
0.02448277,
-0.01359555,
0.019995833,
0.00016821799,
0.013656184,
0.02177444,
-0.017476143,
0.0055480353,
-0.05287308,
-0.018176805,
-0.025816724,
-0.016196087,
0.015441527,
-0.011156705,
0.014390533,
-0.009034506,
-0.028754117,
-0.014040201,
0.0008231944,
-0.011392505,
-0.015549321,
-0.009768854,
-0.039991666,
-0.0042376616,
0.023445249,
-0.0017204973,
0.00027432793,
0.01788037,
-0.0007541387,
-0.012760145,
0.0023108392,
0.0077477116,
-0.0374585,
0.009688009,
0.026571283,
0.03134118,
0.025695454,
0.01175631,
0.0053223413,
-0.016061343,
0.026706025,
-0.02983206,
0.011540722,
-0.026274849,
0.008118254,
-0.0052482327,
-0.027649226,
0.025318176,
0.019672452,
-0.015657116,
0.024536666,
0.00014242737,
-0.026921615,
0.045839503,
-0.0035066816,
0.020723445,
-0.0073839063,
0.00015758594,
-0.037431553,
0.02137021,
-0.005959001,
-0.0034595218,
0.02363389,
-0.016802428,
-0.005015801,
0.0067775636,
-0.0072424263,
0.004732841,
-0.01976677,
-0.007202003,
0.0018628194,
0.007572546,
-0.009546529,
-0.010617734,
-0.002792545,
-0.013299116,
0.028727168,
0.012187487,
0.02467141,
0.00035285775,
-0.020400062,
-0.016452098,
0.03039798,
0.009303992,
0.0136359725,
0.0104964655,
-0.010166345,
0.0046149413,
-0.003631319,
0.03691953,
-0.0027891763,
0.02052133,
0.0024674777,
0.0026241164,
-0.003230459,
-0.0036178445,
-0.0012547924,
0.02511606,
0.0146600185,
-0.013137424,
0.013905458,
-0.011763047,
0.02756838,
0.0027908606,
-0.0058747865,
-0.0015411209,
-0.011392505,
0.008003723,
0.025641557,
0.035275668,
0.01929517,
0.015980497,
0.0008518272,
0.007922878,
-0.0024236864,
0.0034696274,
-0.008226049,
0.0027133834,
-0.010402145,
-0.009337677,
-0.0028127562,
-0.016357778,
0.0042039757,
0.016047869,
-0.021531902,
0.022326885,
-0.015993971,
0.042066704,
0.014808235,
0.021114198,
0.0021188308,
0.0069662035,
-0.06268236,
0.029966801,
-0.0050764354,
-0.00004737052,
0.0105301505,
-0.026598232,
-0.005638987,
-0.0064878664,
-0.0020447222,
-0.010685105,
0.0140940985,
0.0002816967,
-0.0065754494,
-0.026571283,
0.0057669925,
0.034601953,
-0.014942978,
0.029023603,
-0.025021741,
0.0053324467,
-0.014215367,
-0.017044965,
-0.0071076835,
0.01762436,
0.008832391,
-0.0066765063,
-0.0059556323,
-0.016088292,
-0.02725847,
0.012430024,
-0.0073906435,
-0.0076870774,
-0.008232786,
-0.013487755,
-0.0020160894,
0.008360792,
-0.009162512,
0.020561753,
-0.012140327,
-0.0013491124,
-0.043171596,
-0.020507855,
-0.013157636,
0.039614387,
0.024886997,
0.0021238837,
-0.0077477116,
0.00045980985,
0.023701262,
0.015320258,
-0.019335594,
0.024779204,
-0.023364404,
0.019982358,
-0.0026527492,
0.00801046,
0.000057686768,
-0.003732376,
0.024509719,
0.0017053387,
-0.016479045,
-0.02108725,
-0.027918711,
0.006349755,
0.013137424,
0.03524872,
0.031287283,
0.023701262,
0.003944596,
-0.0048103184,
0.019335594,
0.0011882632,
-0.03055967,
-0.013507967,
-0.004459987,
-0.005463821,
0.022919752,
0.014174944,
-0.027244996,
-0.00059455266,
-0.009728431,
0.018985262,
0.022097822,
0.007707289,
-0.0036346873,
0.035033133,
0.011796733,
0.0067068236,
0.003755956,
-0.016613789,
-0.012510871,
-0.0063598608,
-0.011601356,
0.014606121,
-0.010253928,
-0.03956049,
0.007599495,
0.010792899,
-0.0067708264,
0.00040507058,
-0.015037298,
0.0055008754,
-0.0027992819,
0.002127252,
-0.009816014,
0.00876502,
-0.017220132,
-0.01649252,
-0.024401924,
-0.014848658,
-0.0046654698,
-0.017489618,
-0.002610642,
0.0015023823,
-0.020912085,
-0.013865035,
0.0064710234,
0.024846574,
0.0023175764,
0.025560712,
-0.002516322,
-0.01425579,
0.014606121,
-0.00036822684,
-0.020009307,
-0.018769674,
-0.030209338,
0.010664893,
0.006501341,
-0.0035100502,
-0.037943576,
0.0033870975,
-0.0068314606,
0.048857745,
-0.016721584,
0.019402966,
-0.01491603,
-0.009175986,
0.0015108038,
0.023270084,
0.0005179177,
0.019739822,
-0.00019232431,
-0.005942158,
-0.03780883,
-0.0093781,
-0.006117324,
-0.021262417,
-0.0040624957,
0.012915099,
0.0093309395,
0.0038536445,
-0.021437582,
0.006844935,
0.021707067,
-0.012504133,
-0.013043105,
0.012942047,
0.022232564,
0.012975733,
0.02045396,
0.0012000531,
-0.001440906,
-0.015845755,
-0.011857367,
0.030829156,
-0.0033146732,
-0.024253706,
-0.002752122,
0.0076668663,
-0.00862354,
-0.031017795,
-0.0066057662,
-0.027864814,
0.040638432,
-0.0155762695,
-0.024415398,
-0.03716207,
0.0015798595,
-0.039048467,
-0.0071548433,
-0.0092972545,
-0.0069190436,
-0.012504133,
0.008394477,
0.026274849,
0.015172041,
0.037781883,
-0.033847395,
-0.0031411918,
0.015064247,
0.0029323404,
0.014228841,
-0.01133187,
0.025951466,
0.0051235957,
0.0054031867,
-0.02250205,
-0.027595328,
0.011345345,
-0.01536068,
0.02754143,
0.041689426,
0.033011988,
0.023323981,
0.0043993527,
0.01255803,
-0.00572657,
0.010732265,
-0.027447112,
0.015643641,
-0.008569643,
0.045165792,
0.0022299935,
-0.00087582826,
0.030263236,
-0.041177403,
0.021302838,
0.029320037,
-0.023094919,
-0.016223034,
0.014457904,
-0.035922434,
-0.022811959,
0.026732974,
-0.004389247,
0.00040717595,
-0.05136396,
0.0074378033,
0.022272987,
0.006524921,
0.02238078,
-0.005086541,
0.017206658,
0.006198169,
0.02379558,
-0.00093477825,
-0.0024910579,
-0.00055791944,
-0.023674313,
0.017476143,
-0.0043218755,
0.0018712408,
0.0009086718,
0.0117293615,
0.0027335947,
-0.009108614,
-0.0052179154,
-0.0051168585,
-0.005228021,
-0.014457904,
-0.016519468,
-0.025304701,
-0.009290517,
-0.0052414956,
-0.021545377,
-0.039129313,
0.014498327,
0.009667797,
-0.03225743,
0.0036380559,
0.005716464,
-0.0045509385,
0.010819848,
-0.027972609,
0.0065114466,
-0.019025685,
0.008960397,
0.029104447,
0.016721584,
-0.008044146,
0.0025786406,
-0.00096256897,
0.016007446,
0.035733793,
-0.005622144,
-0.0093781,
-0.028915808,
0.0059455265,
0.0146600185,
-0.018271126,
-0.031233383,
0.02596494,
-0.015468475,
0.015239412,
-0.010590785,
-0.004874321,
-0.039614387,
0.0034325733,
-0.010786162,
0.0051943352,
0.01863493,
-0.006952729,
-0.01903916,
0.014107573,
-0.013730293,
0.036623098,
-0.0027807548,
-0.014700441,
-0.014242316,
-0.0035673159,
-0.0027234892,
0.005551404,
0.0027015933,
0.024253706,
0.0068685147,
0.002900339,
0.01611524,
0.012638876,
0.021262417,
-0.006615872,
0.0044734613,
0.03576074,
0.0130700525,
0.0012219489,
0.0013676395,
0.0031917205,
0.006898832,
-0.014875607,
-0.008643751,
-0.026288323,
-0.021397159,
0.0035673159,
0.023041021,
0.008940185,
-0.025924517,
0.017678257,
-0.032473017,
-0.023755157,
-0.004510516,
-0.022758061,
0.0034797331,
-0.05230716,
-0.030128494,
0.008071095,
0.034736697,
-0.0025196907,
-0.0023849478,
-0.01293531,
0.006767458,
0.015872704,
-0.004662101,
0.0119786365,
-0.0017314452,
0.01378419,
-0.016479045,
0.019834142,
-0.028754117,
-0.0015133303,
-0.001323006,
-0.0046317843,
-0.01819028,
0.0090479795,
0.010961328,
0.023809055,
-0.008475323,
-0.008542694,
0.04538138,
-0.0016404937,
0.00419387,
-0.008347318,
-0.00464189,
0.0037189017,
-0.006979678,
0.0047463155,
0.00426461,
-0.009411786,
-0.013865035,
-0.015481949,
-0.015926601,
0.011176917,
-0.010705316,
-0.02073692,
-0.007478226,
0.011001751,
-0.023472197,
-0.016721584,
-0.01677548,
-0.014013252,
-0.0072087403,
-0.0058680493,
0.019632028,
0.009775591,
-0.01293531,
0.011507036,
-0.01960508,
0.020602176,
-0.018149856,
0.008327106,
-0.00048591627,
-0.032446068,
-0.027676174,
0.000093056755,
-0.032526914,
0.02754143,
0.014471378,
-0.0072424263,
-0.03786273,
0.0014249053,
-0.05529845,
-0.022367308,
-0.009344414,
0.0025786406,
0.008832391,
0.011284711,
-0.030478824,
0.0076466547,
-0.002747069,
-0.009674534,
0.006811249,
-0.0077275005,
0.01703149,
0.0003732797,
0.014686966,
-0.011944951,
-0.024496244,
-0.030856105,
-0.005238127,
0.0049585355,
0.0087313345,
0.0133193275,
-0.001624493,
0.016667686,
-0.006373335,
0.040800124,
0.002704962,
0.018042063,
0.037970524,
-0.042902112,
0.021504954,
0.01074574,
0.0062992265,
-0.030209338,
0.028242094,
0.008785231,
0.011149968,
0.009196197,
0.018149856,
-0.008374265,
-0.015414578,
0.004129867,
0.030478824,
-0.000027895972,
-0.0038536445,
0.01753004,
0.008495535,
-0.028349888,
-0.029535625,
0.01232223,
0.004662101,
-0.014134521,
0.018958313,
-0.018136382,
-0.0068483036,
0.0090479795,
0.000785719,
-0.016249983,
-0.014862132,
0.009371363,
-0.025089111,
-0.005440241,
0.006875252,
-0.0024371606,
-0.005834364,
-0.032931145,
0.013184585,
-0.018325023,
-0.011688939,
-0.009384837,
0.021424107,
-0.020346165,
0.007707289,
-0.0019756665,
-0.016371252,
-0.0046385215,
0.006467655,
-0.030101545,
-0.0050595924,
0.030990846,
0.18605287,
-0.013743767,
0.010395408,
-0.0051808613,
0.01368987,
0.0034595218,
0.023943799,
-0.005878155,
-0.025937991,
-0.011857367,
0.028915808,
0.0037525874,
0.010806373,
-0.013258693,
0.018890942,
0.005568247,
-0.021504954,
-0.0023226293,
-0.021114198,
-0.01759741,
0.005379607,
0.00095583184,
0.014147995,
0.024860049,
0.022421204,
0.0002515901,
-0.047941495,
-0.006474392,
0.01960508,
0.011891053,
-0.0045745187,
0.00019485074,
-0.008542694,
0.004796844,
-0.004530727,
0.010900694,
-0.009647585,
-0.00037896415,
-0.0040085986,
0.0055985637,
0.017422246,
0.005770361,
-0.0071144206,
0.0055716154,
-0.016856326,
0.0018325023,
-0.015751434,
-0.026557809,
-0.024577089,
0.008354055,
-0.037539348,
-0.024604037,
0.028808013,
0.029293088,
-0.006410389,
-0.025560712,
0.01368987,
0.036084127,
0.017300976,
0.025304701,
-0.027015934,
0.004375773,
-0.010577311,
0.011446402,
-0.042336192,
0.017745629,
0.0081317285,
-0.004766527,
0.012214436,
-0.024186336,
-0.016977595,
-0.018796623,
0.00012737406,
0.010678368,
0.0045610443,
-0.023121867,
0.018095959,
0.008050883,
-0.002728542,
-0.00078824547,
0.019120006,
-0.0052650752,
-0.018055538,
0.029023603,
-0.02089861,
-0.02961647,
0.01658684,
0.007323272,
-0.01948381,
-0.031098641,
0.000012395286,
-0.00786898,
-0.02269069,
0.011257762,
0.0074984375,
-0.008643751,
-0.0050831726,
-0.002704962,
-0.01819028,
-0.002711699,
-0.03314673,
0.08769062,
0.0005398134,
-0.006241961,
-0.032311328,
-0.008320369,
-0.009856436,
0.011675465,
-0.014336635,
-0.012093168,
0.010934379,
-0.021329787,
0.009586951,
-0.019079583,
-0.008226049,
0.00504275,
0.021235468,
0.00022337832,
0.039425746,
-0.018392393,
-0.005457084,
-0.019807193,
0.02640959,
-0.007983511,
-0.008832391,
0.010718791,
-0.009539791,
-0.014713915,
-0.0009650954,
-0.029697316,
-0.014188418,
0.009674534,
0.0016851273,
0.002846442,
0.013251956,
0.006821355,
0.0025685348,
-0.016317355,
0.004564413,
0.029104447,
0.008515745,
-0.0025954836,
0.032877248,
0.01117018,
0.002073355,
-0.0057400437,
0.031853203,
0.016640738,
-0.0075321235,
-0.014592647,
-0.014417481,
-0.0010063604,
0.005140438,
-0.0027639118,
0.021963079,
0.001536068,
-0.003944596,
-0.010375197,
-0.009364625,
-0.0058040465,
-0.022865856,
0.013851562,
0.012632139,
0.0021070407,
-0.01903916,
-0.003644793,
-0.16988374,
0.00838774,
0.028538527,
-0.021046827,
0.041392993,
-0.016896749,
0.022178667,
-0.01213359,
-0.006295858,
0.0059084725,
0.021383684,
-0.011608093,
-0.020400062,
-0.031529818,
-0.008866077,
0.023000598,
-0.014929504,
0.022892805,
0.019685926,
0.01819028,
0.005190967,
-0.01378419,
0.01668116,
-0.018607983,
-0.016519468,
-0.011446402,
0.0011840524,
-0.021558851,
-0.0011124704,
-0.00070361013,
-0.02379558,
-0.021410633,
0.040207256,
-0.019968884,
0.016290406,
0.002191255,
-0.026423065,
0.0012446868,
-0.01536068,
0.024509719,
0.016276931,
0.03055967,
0.005356027,
-0.007612969,
-0.020480908,
0.014767813,
0.02754143,
0.003520156,
0.035113975,
-0.017786052,
0.011944951,
-0.009128826,
0.013245218,
0.020561753,
0.019914988,
0.014538749,
0.018527137,
-0.0187562,
-0.0043926155,
-0.016411675,
-0.012328967,
0.017556988,
0.017678257,
-0.0074041174,
-0.0021188308,
-0.034036033,
-0.0049113757,
-0.0041130246,
-0.022555947,
0.015064247,
-0.024159387,
0.015535846,
0.013865035,
-0.025547238,
0.01255803,
0.007323272,
-0.010415619,
0.0016345987,
-0.024374975,
0.01731445,
-0.019456862,
0.03716207,
-0.019160427,
-0.03543736,
-0.003425836,
0.03452111,
0.009627374,
0.02325661,
0.00007842453,
-0.0117293615,
0.018540611,
-0.026706025,
0.012827516,
0.00012611086,
0.021963079,
0.033631805,
-0.00417029,
0.0060499525,
0.020278793,
0.00012590032,
0.033604857,
-0.012632139,
0.0028952863,
0.017893845,
0.035652947,
0.006349755,
-0.008050883,
0.0067539834,
0.022852382,
-0.017071914,
-0.0012118432,
-0.005214547,
0.0037054273,
0.00895366,
-0.007842031,
0.01759741,
0.010375197,
-0.0041500786,
-0.0075590718,
-0.0148351835,
0.09049328,
0.021976553,
-0.0017937637,
0.04106961,
0.010267402,
-0.027501008,
-0.13064663,
-0.041662477,
-0.008226049,
0.015172041,
0.0026611707,
0.015791858,
0.00829342,
0.008226049,
-0.011769785,
0.031395074,
-0.024065066,
-0.024401924,
0.013379961,
-0.0065417634,
0.0045980983,
0.010105711,
0.021302838,
-0.01649252,
-0.032715555,
0.036757838,
-0.004129867,
0.011850631,
-0.001972298,
-0.010125922,
-0.0056019323,
0.010516676,
-0.031044744,
0.037593246,
0.005568247,
0.007673603,
0.030802207,
-0.019739822,
0.035679895,
0.013770715,
-0.013891984,
-0.005723201,
-0.0040624957,
-0.010031602,
0.027622277,
-0.030236287,
0.009344414,
-0.011015225,
0.015684063,
-0.003360149,
0.008266471,
-0.015778383,
-0.019146955,
0.0134608075,
0.026867718,
-0.016600315,
-0.019807193,
-0.026113158,
-0.02149148,
-0.0072693746,
0.021060301,
-0.013514704,
0.007862243,
0.028242094,
-0.006945992,
-0.0042477674,
-0.005268444,
-0.009364625,
-0.0017903951,
-0.025318176,
0.014781287,
-0.009822751,
-0.019402966,
-0.030694412,
0.025951466,
-0.018904416,
0.0018863993,
0.010280876,
-0.020157525,
-0.004884427,
-0.022744587,
-0.010476254,
-0.014134521,
-0.012302019,
0.018325023,
-0.029077498,
-0.023000598,
-0.020440485,
0.003786273,
-0.013716819,
0.013245218,
0.008205838,
0.0073839063,
-0.009593688,
-0.0009827804,
0.007511912,
0.003496576,
0.009533054,
-0.005174124,
-0.0046486272,
-0.01705844,
0.011075859,
-0.001340691,
0.009539791,
0.007572546,
0.02926614,
-0.019160427,
-0.020965982,
-0.05192988,
0.01573796,
0.03355096,
0.011163442,
0.00066655583,
-0.012504133,
0.015684063,
0.00032296169,
0.017044965,
-0.010132659,
-0.039048467,
0.0022485207,
-0.0041669216,
-0.019025685,
-0.028053453,
-0.019807193,
0.030263236,
0.0030199233,
0.008946923,
0.017098863,
0.0050191698,
0.0055177184,
-0.0046755755,
-0.004988853,
0.018837046,
-0.012113379,
-0.016694635,
0.01705844,
-0.004790107,
-0.020979457,
-0.0024354763,
-0.03713512,
-0.02262332,
-0.00876502,
-0.000081477294,
-0.013932407,
-0.0017971323,
0.018432816,
0.005692884,
0.042066704,
0.0009086718,
-0.011149968,
0.022353834,
0.011318397,
-0.0103886705,
-0.0021036721,
-0.016452098,
-0.009364625,
0.009243357,
-0.017381823,
0.027757019,
0.01759741,
0.0014863816,
-0.022852382,
-0.04239009,
0.006881989,
0.015320258,
-0.0027622278,
0.0020868294,
-0.032122687,
-0.0015377523,
0.00085772225,
-0.0010072025,
0.011217339,
-0.0076668663,
-0.0075927577,
-0.0281343,
0.010584048,
0.014161469,
-0.03150287,
-0.024132438,
0.011325133,
0.019658977,
-0.02035964,
0.01232223,
0.005665935,
-0.00428819,
-0.0034797331,
-0.004227556,
-0.0008050883,
0.0065754494,
-0.011668728,
-0.023674313,
0.022798484,
0.019524233,
-0.008401214,
-0.021073775,
0.026665602,
-0.0014678545,
-0.0010248875,
-0.0127197215,
0.022434678,
-0.007976774,
0.01885052,
-0.01298247,
0.011008488,
-0.0009650954,
0.011533985,
0.006420495,
0.011742836,
0.016007446,
-0.013487755,
0.006952729,
0.009546529,
-0.018648405,
0.020063205,
-0.027218048,
-0.026220951,
-0.009829489,
-0.0033534118,
0.019241273,
0.02184181,
-0.002640959,
0.0063632294,
-0.0016320724,
0.020413537,
-0.006625978,
0.0022822064,
0.003489839,
0.03524872,
0.018581035,
0.012389602,
0.00023579992,
-0.018311549,
0.009499368,
0.010260665,
0.014794761,
-0.024415398,
0.012200962,
0.003053609,
0.03726986,
0.014794761,
-0.029077498,
-0.007282849,
-0.021572324,
-0.024186336,
0.024806151,
0.0131778475,
-0.016249983,
0.08596592,
0.0013962724,
-0.011924739,
-0.013150899,
-0.0068853577,
0.0019605078,
0.01630388,
-0.008771758,
-0.034952287,
-0.032499965,
-0.0052953926,
-0.017179709,
0.019025685,
-0.03349706,
-0.016883275,
0.015374155,
0.0054537156,
0.03452111,
0.0042679785,
-0.009553266,
0.005221284,
0.005581721,
0.019173902,
0.018621456,
-0.01976677,
0.013346275,
0.021787914,
-0.0098968595,
0.008084569,
-0.027150678,
-0.0090142945,
-0.0059691067,
-0.027339317,
-0.0060499525,
0.01340691,
-0.020790815,
-0.01816333,
-0.021666644,
0.014686966,
0.013278904,
-0.003107506,
0.019726347,
-0.013710082,
-0.015562795,
-0.0023950534,
0.0021659906,
0.009795803,
0.0020278792,
-0.024792677
] |
Loss of cell polarity proteins such as Scribble induces neoplasia in Drosophila by promoting uncontrolled proliferation. In mammals, the role that polarity proteins play during tumorigenesis is not well understood. Here, we demonstrate that depletion of Scribble in mammary epithelia disrupts cell polarity, blocks three-dimensional morphogenesis, inhibits apoptosis, and induces dysplasia in vivo that progress to tumors after long latency. Loss of Scribble cooperates with oncogenes such as c-myc to transform epithelial cells and induce tumors in vivo by blocking activation of an apoptosis pathway. Like depletion, mislocalization of | [
-0.031373505,
-0.008566236,
-0.00492491,
-0.021375056,
-0.025833823,
0.013477636,
-0.0332651,
0.035048608,
-0.020186052,
-0.007167805,
0.025833823,
0.00983631,
0.026401302,
0.026347257,
-0.021739865,
0.0033018517,
0.021739865,
0.0077555515,
-0.014105916,
0.03277869,
-0.024144897,
0.022564061,
-0.008775664,
-0.025374435,
-0.009228296,
0.002072313,
-0.0063773873,
-0.039993785,
-0.0027799734,
0.014214007,
0.02273971,
0.008390588,
0.012842598,
-0.0036683488,
-0.021469636,
0.0156056825,
0.019334832,
-0.012072449,
-0.0039081764,
-0.0033778534,
0.001775062,
0.011700884,
-0.011876533,
0.005999068,
-0.033967692,
0.0047796625,
0.00207738,
-0.0019253765,
-0.009876844,
0.000466566,
0.005671416,
-0.00341501,
-0.014740952,
-0.015848888,
-0.005299852,
-0.0018561304,
0.020780554,
0.0124575235,
-0.011423901,
0.006772596,
0.016510949,
0.0070056682,
-0.010052492,
-0.003322119,
-0.0073164306,
0.0062760515,
-0.011835999,
-0.007877154,
0.0013477636,
0.011917067,
0.05334306,
0.038102187,
-0.020780554,
-0.01615965,
0.0039284434,
-0.012369699,
-0.02732008,
-0.0014381211,
-0.008370321,
0.015173318,
0.017159496,
-0.025266344,
0.0074583003,
0.018605217,
0.014916601,
-0.007073225,
-0.009795775,
-0.0048066853,
-0.0075258575,
0.00926883,
0.020564372,
0.023172075,
0.004242584,
-0.002259784,
-0.017375678,
0.0018865311,
-0.0013224296,
0.044938963,
-0.0018240409,
-0.033940673,
-0.011606304,
0.016389346,
-0.018605217,
-0.01112665,
-0.020969715,
0.0033136741,
0.0071542934,
-0.014065382,
0.02102376,
-0.031400524,
-0.022969404,
0.027252521,
-0.0017716842,
-0.06680043,
0.028752288,
-0.014930112,
0.025401458,
0.026306722,
-0.02588787,
-0.0051917606,
0.013876222,
0.003386298,
0.024996115,
-0.034832425,
0.03258953,
0.0121940505,
0.020699486,
0.0076474603,
-0.010201117,
-0.0034200766,
0.012099471,
0.019618573,
0.007850131,
-0.0098025305,
-0.00015538126,
-0.0030535795,
-0.014200496,
-0.0043236525,
-0.0011873154,
-0.0094107,
-0.004178405,
0.031562664,
-0.018497126,
-0.0024320544,
-0.0009424211,
0.020631928,
0.013943779,
-0.0015386123,
0.005691683,
0.013504658,
0.012085959,
-0.023671998,
0.013396567,
-0.026239166,
0.015997514,
0.042479884,
-0.0033710978,
0.036075477,
-0.015551637,
-0.019469947,
-0.008268985,
-0.004448633,
0.02837397,
0.018632239,
0.021807421,
0.029589996,
-0.0014094093,
0.018956514,
0.003252873,
0.0002413054,
0.0016796376,
0.024955582,
-0.030535795,
0.023523372,
-0.014822021,
0.015051715,
-0.00093904324,
0.027455192,
-0.030265566,
-0.017281098,
-0.024955582,
0.038102187,
0.009951157,
0.013268208,
-0.006748951,
-0.013457368,
0.022307344,
-0.020307655,
-0.01682171,
-0.007255629,
-0.019861778,
0.013288476,
0.008275741,
-0.0052626957,
-0.6264972,
-0.03791303,
0.023158563,
-0.016308276,
0.0036818602,
0.034264944,
-0.0011037136,
-0.013376299,
-0.025225809,
0.017632395,
-0.0030856691,
-0.010437567,
0.000909487,
0.015240875,
-0.0102956975,
-0.020537348,
-0.006630726,
-0.01817285,
0.015646217,
0.0148085095,
-0.023739554,
0.008377076,
0.004789796,
0.020442769,
0.005323497,
0.03450815,
0.021645285,
-0.010714551,
0.006978645,
0.03280571,
-0.034724332,
0.0074042547,
-0.019564528,
-0.01661904,
0.045263235,
0.020915668,
-0.0062861852,
0.01614614,
0.016213696,
0.029508928,
-0.005765996,
0.0102213845,
-0.0024928558,
0.02388818,
-0.009883599,
-0.005556569,
0.0099916905,
-0.0036075474,
0.019159185,
0.004310141,
-0.008410855,
0.018389035,
-0.03710234,
-0.012991224,
0.022482993,
0.02609054,
0.039777603,
-0.03280571,
0.01051188,
-0.0019692886,
0.007701506,
0.00095508806,
-0.013011492,
-0.0064618336,
0.0042020497,
0.021375056,
-0.010059248,
0.019348344,
0.0045465906,
-0.009052647,
0.010592949,
0.021591239,
-0.008383832,
0.003779818,
0.0017066605,
0.045533463,
-0.011315809,
-0.008904021,
0.011234741,
-0.00021639373,
0.01797018,
-0.009748485,
-0.03507563,
0.011038825,
0.033481285,
-0.0011982935,
-0.013605993,
0.034886472,
-0.010174095,
0.005765996,
0.019537505,
0.017186519,
0.00062068057,
-0.055288706,
-0.027036339,
0.016132629,
-0.021212919,
0.0045499685,
-0.016105605,
-0.034264944,
-0.019888802,
0.015416523,
0.0011231363,
-0.008390588,
0.015294921,
0.0008368632,
-0.04423637,
0.022374902,
0.024239477,
-0.026333746,
-0.00024046094,
0.006194983,
0.004148004,
-0.030373659,
-0.014673395,
-0.014943624,
0.026901225,
0.00044460996,
-0.0033440748,
-0.022023605,
-0.00075452804,
-0.015240875,
0.010849665,
-0.0045533464,
0.01672713,
-0.0024050316,
0.012085959,
-0.005644393,
-0.001889909,
-0.01855117,
0.006198361,
-0.025658175,
0.019618573,
-0.027130919,
0.0011163806,
0.0076677273,
-0.00039394214,
-0.0040230234,
-0.0036751046,
-0.002398276,
-0.036994252,
0.001359586,
0.010809131,
-0.0033457638,
-0.0061341817,
-0.020388724,
-0.021064295,
-0.005326875,
0.011133405,
0.00028331747,
-0.011977868,
-0.005674794,
0.0055667027,
0.015551637,
0.0008909088,
0.009640394,
-0.014038359,
0.0013334076,
0.0047425064,
-0.027225498,
-0.00023708309,
0.020767042,
-0.006059869,
0.0013823865,
-0.018834911,
-0.009322875,
0.010214629,
-0.008471657,
0.011781952,
-0.035426926,
-0.02273971,
-0.010329476,
-0.008944556,
-0.0044824113,
-0.006870554,
0.018321477,
-0.018280942,
-0.0040905806,
-0.010998291,
0.0021736487,
0.0043337857,
-0.03040068,
-0.0063233417,
0.0020064448,
0.041128743,
0.008262229,
0.055937253,
0.012261608,
0.0027951738,
0.033048917,
-0.00042328725,
0.008458145,
-0.015984003,
0.008775664,
0.004701972,
-0.032859758,
0.021753376,
0.0121940505,
-0.015254386,
0.028049694,
0.012849354,
-0.025941914,
0.00071906054,
-0.0014921668,
0.016186673,
-0.01682171,
0.0064415666,
-0.015457057,
-0.007100248,
0.009620126,
-0.016564993,
0.02867122,
-0.009559325,
-0.0008672639,
-0.010842909,
0.0008313742,
-0.0045736134,
-0.019807732,
-0.0012472724,
-0.00054974563,
-0.03096816,
0.011511724,
0.018578194,
-0.007032691,
-0.0019507103,
0.030265566,
0.024415124,
0.006863798,
0.0022209387,
-0.025752755,
-0.0016948379,
0.018051248,
0.00010101893,
-0.004769529,
-0.008836465,
0.015835376,
0.0060767583,
-0.0056207483,
0.04034508,
-0.019632084,
0.006012579,
0.024739398,
0.014849043,
-0.009545814,
-0.007769063,
-0.010478102,
0.02972511,
0.0049890894,
0.007512346,
-0.00016762597,
-0.014781486,
0.017726975,
-0.02550955,
-0.0029066429,
0.0039960006,
-0.021537194,
-0.000023803312,
0.0137073295,
0.05064078,
0.02772542,
0.007823109,
-0.005897732,
0.005894354,
0.00031350701,
0.013801909,
0.0011805597,
0.018861935,
0.005245806,
-0.019821243,
-0.0133290095,
-0.032832734,
0.005245806,
0.022766732,
-0.051370393,
-0.0030046005,
-0.00022040494,
0.008268985,
0.021631774,
0.017078428,
0.015254386,
-0.0091945175,
-0.027671376,
0.02867122,
0.011227985,
-0.01032272,
-0.015294921,
-0.023104517,
-0.019415902,
0.011592793,
0.022428947,
0.02111834,
0.008160894,
0.005988934,
0.016794687,
-0.02369902,
-0.027009316,
-0.0038102188,
-0.016835222,
0.013808665,
0.016375834,
0.012200806,
0.018510636,
0.002075691,
0.013430345,
0.029644042,
-0.00017395946,
0.0036683488,
-0.005985556,
-0.036237612,
-0.033211056,
-0.03804814,
-0.020618418,
-0.012052181,
-0.017105449,
-0.0031447816,
-0.0004332097,
0.034616243,
-0.007140782,
0.02791458,
0.019145673,
-0.03334617,
-0.014916601,
-0.01672713,
-0.015254386,
0.02848206,
0.052694514,
-0.0024776554,
0.01872682,
0.0012987846,
0.011363099,
-0.006711795,
-0.023104517,
0.020537348,
-0.017227052,
-0.0016188363,
-0.00057761295,
-0.0035163455,
-0.0021044028,
0.010896956,
0.022091161,
-0.0009077981,
-0.020861622,
-0.0059382664,
0.00040492017,
0.0062490287,
-0.014024847,
0.011883289,
0.0032934071,
0.022955893,
-0.004695216,
-0.007721773,
0.0050634025,
-0.0035163455,
-0.0039993785,
-0.026104052,
0.0045972588,
0.0018139073,
0.027833512,
-0.00008666305,
-0.024969094,
0.031238388,
0.020794066,
-0.013849199,
0.0034031873,
0.012876377,
0.004239206,
-0.0067793517,
-0.009640394,
0.0040061343,
-0.0128358435,
-0.012748019,
0.0146193495,
-0.013106071,
-0.030887092,
0.037886005,
-0.020415746,
0.016551482,
-0.012423745,
0.015308431,
-0.0029539329,
0.005458611,
0.0009398877,
-0.008046047,
-0.012504813,
-0.020118495,
-0.0057220836,
-0.005468745,
-0.0075055906,
-0.0015681685,
-0.018037738,
-0.017916135,
-0.0051850053,
-0.036102496,
-0.0054282104,
0.012592638,
-0.035616085,
-0.043155454,
-0.0012827398,
0.00035488573,
0.024496194,
0.018132318,
-0.015294921,
-0.017443236,
0.016375834,
0.03485945,
-0.021253454,
0.019132162,
-0.024779933,
0.013261452,
0.005353898,
-0.00069626,
-0.028428014,
-0.026414813,
0.0006236362,
0.0049586887,
0.016686596,
-0.0015842132,
-0.006519257,
-0.013356033,
-0.010579437,
0.024334056,
0.025063673,
0.010153827,
0.0034622997,
0.017983692,
-0.03372449,
-0.022645129,
0.004813441,
-0.019348344,
-0.02609054,
0.001257406,
0.013389811,
-0.009390432,
0.00769475,
0.008370321,
-0.0013106072,
0.0023678753,
0.0014001202,
0.000025004032,
0.012585882,
-0.011863021,
0.012369699,
-0.026455348,
0.004479034,
-0.0017547949,
-0.02571222,
0.018483615,
0.011194206,
-0.0070394464,
0.0066712606,
-0.008086581,
-0.027968626,
-0.036913183,
-0.014470724,
-0.004178405,
0.017348655,
-0.0013891422,
-0.037345547,
-0.014389656,
0.007816353,
0.0040128897,
-0.004148004,
-0.015146295,
-0.022428947,
-0.0091202045,
0.011930578,
0.016875755,
-0.03553502,
0.022023605,
-0.035291813,
0.00029703998,
0.029508928,
0.011295542,
-0.014822021,
-0.0010116671,
0.0038068409,
-0.0043135188,
-0.013876222,
-0.0067793517,
-0.03345426,
-0.0035129676,
-0.011464435,
0.040128898,
0.035318837,
0.03907501,
0.03553502,
0.023212608,
0.017470257,
0.015808353,
0.006870554,
-0.010694284,
0.012829088,
-0.026428325,
0.028049694,
-0.003617681,
0.0029235322,
0.02064544,
-0.020685975,
0.022496505,
0.009944401,
-0.0047864183,
-0.021158874,
0.015267897,
-0.025212297,
-0.039912716,
0.011430656,
-0.0025874358,
0.006269296,
-0.025982449,
-0.00081237376,
0.017537815,
0.0222533,
-0.0149976695,
-0.025455503,
0.027184965,
0.013849199,
0.04234477,
-0.010214629,
0.00673544,
-0.013457368,
-0.016227208,
0.010951001,
-0.023455814,
-0.015132783,
-0.023253143,
0.016416367,
0.002676949,
-0.006475345,
-0.0067962413,
0.0056275036,
0.0017683062,
-0.036264636,
-0.012545348,
-0.013680306,
-0.031778846,
-0.025590617,
-0.023550395,
-0.039993785,
0.0034724334,
0.0135587035,
-0.037507683,
0.015916446,
0.008275741,
-0.015078737,
-0.0015470568,
-0.028725266,
0.013774887,
-0.035589065,
0.0076474603,
0.028833358,
-0.009924133,
-0.01671362,
0.0052728294,
-0.013025003,
0.0014583882,
0.01892949,
0.03334617,
-0.014767976,
-0.0008672639,
-0.021550706,
-0.0037899516,
0.0026651265,
-0.034805402,
0.006292941,
0.012916911,
-0.0050127343,
-0.028617173,
-0.0009153983,
-0.035697155,
-0.0060531134,
-0.001867953,
-0.005654527,
-0.018997047,
-0.01825392,
-0.014538282,
0.014308587,
-0.0048539755,
0.02064544,
0.0089378,
-0.0074515445,
-0.006414544,
-0.0034859448,
-0.029995339,
0.01471393,
0.013193895,
0.015538126,
0.0061679604,
0.006519257,
0.0080190245,
0.009525547,
0.021564217,
0.005353898,
-0.013025003,
0.042074542,
-0.0037494174,
0.001775062,
-0.015632706,
-0.018389035,
0.0079447115,
-0.017699951,
-0.009863332,
-0.014673395,
-0.038561575,
-0.007329942,
0.022793755,
0.007877154,
-0.00052736735,
-0.0063976543,
-0.015794843,
0.006917844,
-0.025685197,
-0.012248097,
0.014295076,
-0.03629166,
-0.018618729,
0.01175493,
0.033778533,
0.00077775074,
0.015294921,
-0.02588787,
0.018213386,
0.055099547,
-0.008572992,
0.018294454,
-0.0023408525,
-0.0019169318,
-0.033697467,
0.014308587,
-0.013774887,
-0.03104923,
0.00812036,
-0.021969559,
-0.016024537,
0.005137715,
-0.023590928,
0.032562505,
-0.0011949156,
-0.01663255,
0.0032376726,
-0.005249184,
0.01967262,
-0.01902407,
-0.019442925,
0.0045094346,
-0.013193895,
-0.008160894,
-0.005597103,
0.01671362,
-0.026590463,
-0.0042560953,
-0.004377698,
0.013301987,
-0.012058937,
0.003898043,
-0.006384143,
-0.004833708,
-0.00063714763,
-0.010315964,
-0.015781332,
0.004769529,
-0.011592793,
0.017186519,
-0.004354053,
-0.0058436864,
-0.014362633,
-0.008417611,
-0.016605528,
0.015430034,
-0.008708106,
-0.011450923,
-0.0011239807,
-0.026482372,
-0.025941914,
-0.00003346186,
-0.013828932,
0.0149976695,
0.017254075,
-0.0163353,
-0.009451234,
-0.012916911,
-0.033481285,
-0.036940206,
-0.010072759,
-0.0043371636,
0.011910311,
0.015497591,
-0.0062422734,
-0.002884687,
0.0032596285,
0.024063827,
0.00783662,
-0.0077555515,
0.008275741,
-0.035291813,
0.006539524,
-0.010856421,
-0.017213542,
-0.017983692,
0.025820311,
0.017916135,
-0.014970646,
0.01853766,
-0.019821243,
0.0076609715,
-0.020658951,
0.021212919,
0.018510636,
0.017618883,
0.024374591,
-0.0021753376,
-0.0151868295,
-0.0008655749,
-0.008268985,
-0.027968626,
0.01930781,
-0.008113604,
0.011363099,
0.0102213845,
-0.022415435,
-0.013362789,
-0.0144301895,
0.0011307364,
0.0217804,
0.021753376,
0.016281253,
0.027968626,
0.010342987,
0.011038825,
-0.029752133,
0.00783662,
-0.024861,
-0.009167494,
0.0021314255,
-0.026239166,
-0.012140005,
0.007235362,
0.007390743,
-0.045236215,
-0.0009964667,
-0.016470414,
-0.00088837545,
-0.023901692,
0.026320234,
-0.009059403,
0.0065834364,
-0.00043088742,
-0.0038271078,
-0.01424103,
-0.026644507,
0.017537815,
-0.0056984387,
-0.0075393687,
0.031292435,
-0.009424211,
0.009045891,
-0.007194828,
-0.0049823336,
0.0023273411,
-0.01046459,
0.011336076,
0.18008012,
-0.011133405,
0.0040061343,
0.014322098,
0.012876377,
-0.01663255,
0.0074110106,
-0.0038338637,
0.010403789,
-0.009586348,
0.019605061,
-0.0074988347,
-0.01261966,
0.009262074,
0.011275275,
-0.00922154,
-0.03145457,
-0.017335143,
0.0057018166,
-0.039588444,
0.0163353,
-0.020064449,
0.008025779,
0.021793911,
0.048235748,
0.0043439195,
-0.030184498,
-0.0048708646,
0.013160117,
0.023590928,
-0.03696723,
-0.0008993535,
0.00590111,
-0.00021027138,
0.007377232,
0.025104206,
-0.033697467,
-0.01634881,
0.0064922343,
-0.0003971089,
-0.009809286,
-0.011052337,
0.019334832,
-0.0022851177,
-0.0028103741,
0.016510949,
0.0061612045,
-0.0011704263,
0.022428947,
0.009417456,
-0.03240037,
0.009228296,
0.035318837,
0.02350986,
0.0011138471,
0.0026820155,
0.0015259453,
-0.011038825,
0.00045347682,
0.032616552,
-0.02523932,
0.014673395,
-0.016781176,
0.020361701,
-0.022185741,
-0.011822487,
-0.011768442,
0.015065227,
0.0100322245,
-0.046965674,
0.0011425589,
-0.018051248,
-0.030643886,
0.007255629,
-0.0013933645,
-0.02350986,
0.031968005,
0.008471657,
0.012538592,
0.02149666,
0.01701087,
-0.0002197716,
-0.009775508,
0.00028226187,
0.0023256522,
-0.042696066,
0.020469792,
0.0049688225,
-0.0104848575,
-0.010552414,
-0.0053032297,
-0.017213542,
-0.0037426616,
0.022212764,
0.022847801,
-0.01949697,
0.014268053,
0.035129678,
-0.025658175,
0.0032562506,
-0.027360613,
0.07490728,
0.020307655,
0.005624126,
0.009734973,
0.0069043324,
0.01576782,
0.013450612,
-0.0093093645,
-0.017132472,
0.00031034029,
-0.018659262,
0.0017125717,
-0.0027563283,
-0.014443701,
0.035994407,
0.019767199,
-0.013126339,
0.0326706,
0.015781332,
-0.011072604,
-0.026779622,
0.019605061,
0.02733359,
-0.014362633,
-0.005212028,
-0.02723901,
0.00031012917,
-0.000366286,
-0.010160583,
-0.006958378,
-0.030751977,
-0.010768597,
0.009228296,
0.0057930187,
-0.014078893,
0.023185587,
-0.016659573,
0.00096691056,
-0.012545348,
-0.036480818,
0.0035366125,
-0.02791458,
0.003550124,
-0.014916601,
-0.00511407,
0.014403167,
0.013741108,
-0.011038825,
-0.025360923,
-0.022631617,
-0.015146295,
-0.0017666173,
0.0068029966,
0.01132932,
-0.039426304,
-0.014578816,
-0.028968472,
-0.00045347682,
0.00012086382,
-0.033778533,
0.014794998,
-0.008262229,
-0.021658797,
0.0021972936,
0.0012388277,
-0.17067617,
-0.002420232,
0.010336231,
-0.018902468,
0.008350054,
0.01199138,
0.0014246097,
0.0094107,
-0.0060396018,
0.0011265142,
0.0192943,
0.020442769,
-0.029968316,
-0.019794222,
0.0023087629,
0.016956825,
0.008350054,
0.019537505,
0.0124575235,
0.023253143,
0.013903244,
-0.041209813,
0.024901535,
0.00071821606,
-0.014024847,
0.012653439,
0.0060328464,
-0.017213542,
0.0016483925,
-0.011227985,
-0.005877465,
0.0061341817,
0.01817285,
-0.0067692185,
0.028536106,
0.004104092,
-0.019713152,
-0.010964512,
0.0028053073,
0.017578349,
0.016848734,
0.024725888,
0.009228296,
-0.00964715,
-0.009890355,
0.036859136,
-0.00037641954,
0.0091945175,
0.026198631,
-0.003800085,
0.019078117,
-0.007937956,
-0.009768752,
0.025401458,
0.008681083,
0.016808199,
0.019105138,
0.019132162,
0.012106227,
-0.013626261,
-0.02228032,
-0.024388101,
0.053397108,
0.008147382,
-0.0053336304,
-0.035778224,
-0.008660817,
0.030860068,
-0.028833358,
0.005124204,
-0.004884376,
0.01797018,
0.009539058,
-0.028400991,
0.02591489,
0.0055903476,
-0.013531681,
0.0100322245,
-0.015105761,
-0.010775353,
-0.022496505,
0.02187498,
-0.035156697,
-0.027752444,
0.0024810333,
0.0046411706,
-0.0027934848,
0.00575924,
0.006870554,
-0.009755241,
0.009485013,
-0.017578349,
0.0003677638,
-0.0133290095,
0.016389346,
0.029806178,
-0.021766888,
-0.0004547435,
0.0026651265,
-0.0041108476,
0.013166873,
-0.0066712606,
-0.006066625,
-0.0027326834,
0.037021272,
0.020496815,
-0.0016357255,
0.004928288,
0.050965052,
-0.01930781,
-0.023185587,
-0.0022783622,
0.016551482,
-0.01222783,
0.0013401634,
0.01065375,
0.016754152,
0.017564839,
0.020631928,
-0.005880843,
0.081122525,
-0.008174405,
0.0019980003,
0.011457679,
0.0062490287,
-0.020523837,
-0.11835998,
-0.0192943,
-0.0188214,
0.028698243,
-0.024293521,
0.0072150948,
-0.012579126,
0.03880478,
-0.0028086852,
0.039210122,
-0.0062828073,
-0.017281098,
0.014078893,
-0.011430656,
0.00023560527,
0.010079514,
0.03067091,
-0.005988934,
0.006819886,
0.021239942,
0.005884221,
0.0056275036,
0.0030383791,
-0.004695216,
-0.0021972936,
0.011761686,
-0.016700108,
0.013612749,
0.018618729,
0.0030974916,
0.00760017,
-0.017416213,
0.018389035,
0.00086008594,
-0.014484236,
0.008600015,
-0.001647548,
-0.032076098,
0.02245597,
-0.024104362,
-0.0213075,
0.00082968525,
0.022388412,
0.012592638,
-0.030833047,
-0.010248408,
0.0017429724,
0.016767664,
0.023996271,
-0.02428001,
-0.023063984,
-0.007850131,
-0.02371253,
-0.017524304,
0.026603974,
-0.011572526,
0.006080136,
0.02341528,
0.012842598,
-0.010876688,
-0.028725266,
0.0013553636,
-0.009153983,
0.0076407045,
0.012085959,
-0.028860379,
-0.022726199,
-0.034967538,
0.02075353,
-0.013768131,
0.0010834464,
0.0040230234,
-0.012545348,
-0.0015859022,
-0.008694595,
0.0110928705,
-0.0065733027,
-0.0012143384,
0.009944401,
-0.025658175,
0.0064719673,
-0.02541497,
0.030643886,
-0.014835533,
0.039020963,
-0.015443546,
0.020294143,
0.0045465906,
-0.0010226452,
0.0041615153,
0.00788391,
0.047857426,
0.0074380334,
-0.024861,
-0.016551482,
0.00258068,
0.012207562,
-0.0042189388,
0.02025361,
0.010687528,
-0.008377076,
-0.018307965,
-0.05917999,
0.0035670132,
0.011065848,
0.011748174,
0.034832425,
-0.015051715,
-0.008876999,
-0.017145984,
0.004168271,
0.0047425064,
-0.012802064,
0.023374746,
-0.010045736,
-0.018807888,
-0.022591084,
-0.021793911,
0.040561263,
-0.010241652,
0.012484547,
0.055207636,
-0.0014972335,
-0.010066004,
0.01671362,
0.019807732,
-0.0024404991,
-0.010444323,
-0.0027343724,
0.015538126,
0.018294454,
-0.0005379232,
-0.0012253163,
-0.040291037,
0.0017066605,
-0.0066678827,
-0.002950555,
0.0018510637,
-0.014646373,
0.036480818,
0.011444167,
0.040534243,
-0.014349122,
-0.03269762,
0.03115732,
-0.0025637907,
0.012889889,
-0.0019523993,
-0.027293056,
-0.0018578194,
0.016078582,
-0.026104052,
0.026820157,
-0.00014060315,
-0.004681705,
-0.025820311,
-0.0011982935,
-0.010910466,
0.011248252,
0.0058166636,
0.005279585,
-0.021037271,
0.015848888,
0.0432095,
0.01853766,
-0.004918155,
-0.0028221966,
0.008849976,
-0.035886314,
-0.015078737,
-0.013639772,
-0.034562197,
-0.016402856,
0.013396567,
0.017159496,
0.011227985,
0.012288631,
-0.014767976,
-0.045884762,
0.0068941987,
-0.008897266,
0.021537194,
-0.005897732,
0.0099173775,
-0.013437101,
0.02226681,
0.04077745,
-0.008221695,
-0.008836465,
-0.0017919512,
0.0016146139,
0.0077487957,
-0.015457057,
0.0074988347,
0.006059869,
0.00760017,
0.014092404,
0.00590111,
-0.008336542,
0.02714443,
0.006938111,
0.016510949,
-0.013322254,
0.0025722354,
0.0059348885,
-0.018672774,
-0.017753998,
0.034670286,
-0.012410234,
-0.05474825,
0.0078298645,
0.0003664971,
0.010998291,
-0.0053133634,
0.008221695,
-0.0028272634,
-0.012234585,
0.0124575235,
0.027806489,
0.008370321,
-0.013531681,
0.028887402,
0.025050161,
-0.008350054,
0.00059619115,
0.0022766732,
0.019942846,
-0.012072449,
0.018713308,
-0.033021897,
0.026455348,
-0.029184654,
0.035994407,
-0.007870398,
-0.047911473,
-0.0010091338,
0.0022851177,
0.0036582153,
0.010376765,
0.022874823,
-0.01027543,
0.07847429,
0.0040669357,
-0.01222783,
-0.008066314,
-0.03948035,
0.01853766,
0.021185897,
0.011977868,
-0.02599596,
-0.015092249,
0.01606507,
-0.017605372,
0.03134648,
-0.026739087,
-0.010120049,
0.024401613,
-0.03639975,
0.03180587,
-0.007302919,
-0.013308743,
0.026414813,
-0.028725266,
0.0125723705,
0.015105761,
-0.019645596,
-0.005600481,
0.007465056,
0.009147227,
-0.0017159495,
-0.009093181,
-0.0034420327,
-0.009701195,
-0.024888024,
-0.016200185,
0.0023121408,
0.019037582,
0.007917688,
-0.017983692,
0.010923978,
0.009478257,
-0.017402701,
-0.019794222,
-0.0019980003,
-0.011423901,
-0.0037527953,
0.00391831,
0.016524458,
0.005968667,
-0.020307655
] |
OBJECTIVE Although the Polypill concept (proposed in 2003) is promising in terms of benefits for cardiovascular risk management, the potential costs and adverse effects are its main pitfalls. The objective of this study was to identify a tastier and safer alternative to the Polypill: the Polymeal. METHODS Data on the ingredients of the Polymeal were taken from the literature. The evidence based recipe included wine, fish, dark chocolate, fruits, vegetables, garlic, and almonds. Data from the Framingham heart study and the Framingham offspring study were used to build life tables to model the benefits of the Polymeal | [
-0.008103948,
-0.014054968,
-0.0025066724,
-0.014501802,
-0.02258544,
0.020188782,
0.0121051455,
-0.0012423346,
-0.008374757,
-0.012883721,
-0.0007286445,
0.009776192,
-0.011902039,
0.0015436092,
-0.023194758,
0.0017365604,
0.045685414,
-0.00031544972,
-0.0030313642,
0.0037879357,
-0.0012364107,
0.015530875,
0.01757548,
0.0055041853,
0.0005509263,
0.019430518,
0.045956224,
-0.03729035,
-0.023181219,
0.005057351,
0.018915983,
-0.018848281,
-0.015476713,
-0.01603187,
0.00038124778,
0.0067397496,
0.0051826,
-0.00408244,
0.011116694,
-0.013269623,
0.0074336966,
-0.009600166,
0.014163291,
-0.008638795,
-0.042544037,
-0.0045292745,
0.014840313,
0.015625658,
-0.022707304,
0.014948636,
0.033444867,
-0.002667465,
0.0028282576,
0.0071290373,
0.0020733785,
-0.0138789425,
0.0062726047,
-0.0025659117,
-0.0040587443,
-0.023438487,
0.006408009,
-0.0037270037,
-0.01886182,
-0.0024152745,
-0.0052367616,
-0.009295506,
-0.011644771,
0.0064790966,
-0.0007392229,
0.0016993241,
-0.002747015,
0.04736443,
-0.011035452,
-0.016776595,
0.015178824,
-0.016844297,
-0.024156129,
-0.017033862,
0.015232985,
0.015490253,
0.033688594,
0.0048203934,
0.008334136,
0.040431727,
0.018983684,
0.0096746385,
-0.007068105,
0.0129243415,
0.009363208,
-0.021813635,
0.011048992,
0.02605179,
-0.0054534087,
0.011062533,
-0.03358027,
0.012409805,
-0.0076435735,
0.021461584,
0.014176832,
0.010568307,
-0.006848073,
0.005561732,
-0.0073253736,
-0.014298695,
-0.03322822,
-0.008936685,
-0.0033546418,
-0.028678633,
0.038779795,
0.004620672,
-0.01160415,
0.05746559,
-0.0074878586,
-0.011698932,
-0.011130234,
-0.00471884,
-0.0065095625,
0.0014632129,
-0.0047323806,
-0.012836329,
0.015530875,
0.01600479,
0.023452027,
0.0076029524,
0.027920369,
-0.013242542,
-0.0035746738,
-0.0029602768,
0.011509366,
-0.010067311,
0.008672646,
0.02258544,
0.0132222315,
0.0035746738,
-0.03485307,
-0.0018161103,
-0.027459996,
-0.0047696168,
-0.0056158938,
-0.017602561,
0.01661411,
0.03932141,
-0.015232985,
0.0035103569,
-0.021732392,
0.030113919,
0.03043889,
0.05332222,
-0.009837124,
-0.015598577,
0.011868188,
-0.024548803,
0.01725051,
0.010818805,
0.018049395,
0.032686602,
-0.0021393881,
0.02544247,
-0.009139791,
0.023343705,
0.006688973,
-0.020215863,
0.0122134695,
-0.011529678,
-0.009072089,
0.02166469,
0.0077045057,
-0.0140955895,
-0.01758902,
-0.0028282576,
-0.018238962,
0.031170074,
-0.028786957,
0.0042821616,
-0.002059838,
0.0037506996,
-0.0042821616,
0.010527685,
-0.018049395,
-0.0041907635,
-0.032767843,
-0.0061338153,
0.029247332,
-0.002948429,
-0.018022314,
0.002526983,
0.0138789425,
-0.01665473,
-0.020662699,
-0.015882926,
0.0051690596,
0.015232985,
-0.03265952,
-0.036992457,
-0.64560777,
-0.017345292,
0.017737966,
-0.019823192,
0.033092815,
0.015842305,
0.021461584,
-0.008679417,
-0.0042923167,
0.004451417,
-0.015300687,
0.017697344,
0.013418567,
-0.012118686,
-0.01846915,
-0.021420963,
0.032822005,
-0.056707326,
-0.008239352,
0.0104667535,
-0.029409816,
0.022125065,
0.009072089,
0.0074878586,
0.024332155,
0.00051284384,
0.008029476,
-0.0010705404,
-0.029274413,
0.0017450231,
-0.0049794936,
0.023668675,
-0.028191179,
0.013229001,
0.038048614,
-0.012179618,
-0.0121593075,
0.0016950928,
0.022192767,
0.008997616,
-0.013215461,
0.0021495435,
0.016776595,
0.0016629342,
-0.0017636411,
0.024941474,
0.021488665,
0.03349903,
0.005869777,
0.028001612,
0.012653533,
-0.007250901,
-0.006526488,
0.0019955211,
0.026823595,
0.0131951505,
0.061798528,
-0.024806071,
-0.017088024,
0.02044605,
-0.013973725,
-0.009694949,
-0.010047,
-0.011509366,
-0.008875753,
0.0014555964,
-0.030032678,
0.032903247,
0.0011416277,
-0.029030684,
0.025970547,
0.013215461,
-0.0044751125,
-0.01758902,
0.03328238,
0.0029704322,
0.024318615,
0.0034477324,
-0.011868188,
0.009904825,
0.015111121,
0.014149751,
-0.008313824,
0.014474722,
0.038346503,
-0.0019227413,
-0.012816018,
0.011719244,
0.012992044,
-0.01603187,
0.01508404,
0.010541226,
0.0011179319,
-0.028489068,
-0.0070477948,
0.005710677,
-0.011157315,
-0.0087200375,
0.016451623,
-0.026133033,
-0.02760894,
0.0064418605,
0.007467548,
0.01536839,
-0.010209485,
-0.0044107954,
-0.017358834,
-0.003699923,
0.02196258,
-0.031522125,
0.038184017,
-0.01879412,
-0.014583045,
-0.019092008,
-0.009200723,
-0.030005597,
0.012450427,
-0.009342898,
-0.023276001,
-0.017561939,
0.029978516,
-0.01222701,
-0.012714465,
0.022490656,
-0.00049549516,
0.018848281,
-0.0039639613,
0.0034324995,
0.00721028,
-0.025496632,
0.016411003,
0.006783756,
0.008706497,
-0.013337325,
-0.006313226,
0.010764643,
0.011631231,
-0.0073930756,
0.015517334,
-0.018252501,
0.004200919,
-0.012199929,
-0.009992839,
-0.024846692,
-0.0064249346,
-0.029301494,
-0.008814821,
-0.0035577484,
0.008638795,
-0.007372765,
0.014637207,
-0.011556759,
-0.018807659,
0.0065738796,
-0.0012931112,
-0.0000825649,
0.008300285,
-0.035205122,
-0.010216256,
-0.0047493065,
0.024724828,
0.015571496,
-0.014826773,
-0.0041975337,
0.006458786,
-0.011069302,
-0.011387503,
-0.019376358,
-0.00023568813,
-0.014082049,
0.013906023,
-0.008814821,
0.006032262,
0.023140598,
-0.021935498,
0.055109557,
-0.011746325,
-0.00974234,
-0.044981312,
-0.0025405234,
-0.0065975753,
-0.010480294,
-0.02949106,
0.018062936,
0.035015557,
-0.008740349,
0.0086117145,
0.020757481,
-0.027757885,
0.04492715,
0.015517334,
0.004955798,
0.007569101,
0.011895269,
-0.024264453,
-0.024223832,
-0.001277032,
-0.00076334184,
0.012010363,
0.0054466384,
0.027067322,
-0.015192364,
0.014447641,
-0.03355319,
0.025997628,
-0.027175646,
0.0027842512,
-0.009857434,
0.0012973426,
0.017629642,
-0.0021952423,
0.00007029388,
-0.038048614,
-0.014258075,
0.021813635,
0.015178824,
-0.000843315,
-0.018306663,
-0.008049786,
0.033444867,
-0.004326168,
-0.0033258684,
0.030547213,
-0.02291041,
-0.020676238,
0.022179227,
-0.000050432816,
0.016207896,
-0.015815224,
-0.049774624,
0.0027690183,
0.012599371,
0.0057885344,
0.02005338,
0.02760894,
-0.0027402448,
0.00785345,
-0.02731105,
0.012667074,
0.047526915,
0.0131951505,
0.022016741,
0.016302679,
0.017182808,
0.00847631,
-0.016505785,
0.02984311,
0.01944406,
0.015585037,
0.012294712,
0.01194266,
0.008753889,
-0.011549988,
-0.020364808,
-0.016695352,
-0.017629642,
-0.010805264,
0.028624471,
0.030601375,
0.031765852,
0.020892886,
0.018022314,
-0.021745933,
0.0129514225,
-0.0079820845,
-0.013377946,
-0.0007231437,
-0.016749514,
0.005754683,
-0.01412267,
-0.0027131638,
-0.02166469,
0.02289687,
-0.04148788,
0.0026843906,
0.008449229,
-0.0021106147,
0.03233455,
0.014853853,
0.010764643,
-0.03517804,
-0.026891297,
0.011272409,
0.033526108,
-0.0057851495,
-0.009661098,
-0.023614513,
0.008015935,
0.0088283615,
0.014312236,
0.014731989,
0.0047594616,
0.02385824,
0.0049964194,
-0.01852331,
0.0062285983,
0.01412267,
-0.017467156,
0.023262462,
-0.009193953,
0.0066381963,
-0.010920358,
-0.018618094,
-0.015530875,
0.027703723,
0.0085033905,
-0.011753094,
-0.013648755,
0.0033749526,
-0.020500213,
0.0056429747,
-0.0010375356,
0.013601364,
-0.013344095,
-0.012443656,
-0.0034291144,
-0.012287942,
0.0014598278,
0.0016265443,
-0.014366398,
0.0046579083,
-0.041217074,
-0.009498613,
0.029084846,
0.050316244,
0.020594995,
0.008889293,
0.009146562,
-0.00041848395,
0.014488261,
-0.019999217,
-0.024697747,
0.0016561641,
0.00783314,
0.019037846,
-0.008489851,
0.0065129474,
-0.014407019,
0.0064554005,
-0.018347284,
-0.008699727,
-0.024210291,
0.011990052,
-0.00643509,
0.012809248,
-0.007156118,
0.029220251,
0.02198966,
0.013581052,
-0.009505383,
0.027636021,
0.038806878,
0.00011869035,
0.0017771816,
-0.0026200735,
-0.008950225,
0.0058257706,
0.0057986896,
-0.045902062,
-0.003486661,
0.01069017,
0.010243337,
-0.024088427,
-0.009065319,
0.0057208324,
0.014501802,
0.002725012,
0.017602561,
0.0012753394,
-0.022382334,
0.006868384,
0.0085033905,
0.0038048613,
-0.022368792,
0.0027740959,
-0.0064757112,
-0.02546955,
-0.027784966,
0.027893288,
-0.019525303,
-0.010331349,
-0.01603187,
-0.0144341,
-0.0024423553,
-0.0033901855,
-0.0067972965,
0.0121863885,
-0.0014996028,
-0.002007369,
-0.0035069718,
-0.012734775,
-0.017331753,
-0.0062726047,
0.027784966,
0.005802075,
-0.017602561,
-0.022544818,
0.004488653,
-0.011028681,
0.019389898,
0.011800486,
-0.015300687,
-0.016708892,
0.034825988,
-0.00019178752,
-0.020283567,
0.0011001601,
-0.012599371,
-0.030357648,
-0.020337729,
-0.021894878,
-0.014799692,
0.0041806083,
0.006127045,
-0.004109521,
0.0095663145,
0.0015969246,
-0.03179293,
-0.03517804,
0.0020429126,
-0.00089197594,
0.03550301,
-0.0021952423,
-0.030872183,
-0.012463967,
-0.012829559,
-0.0020462978,
-0.040783778,
-0.009579855,
0.0035679038,
-0.023316624,
0.0022866405,
0.015449632,
-0.0069936328,
0.019552384,
-0.008733578,
-0.023614513,
-0.0045969766,
0.0044344915,
0.0376424,
-0.03458226,
0.025496632,
-0.026133033,
-0.0011407813,
-0.0087200375,
0.00408244,
0.0027233192,
-0.028028693,
-0.032090824,
0.010236566,
0.0019599774,
-0.015490253,
-0.01787337,
-0.005554962,
0.02255836,
0.018496228,
-0.010642779,
-0.029680626,
-0.011935891,
-0.011062533,
0.011448435,
0.003767625,
-0.0030110534,
-0.004762847,
0.00424154,
0.0012990352,
-0.011543218,
-0.001445441,
0.028489068,
-0.035584252,
0.018902441,
-0.008259663,
-0.029951435,
0.021366801,
0.020500213,
0.005297694,
-0.021813635,
-0.005250302,
-0.013784159,
-0.0056599,
-0.0120780645,
-0.013662295,
0.031115912,
0.030953426,
0.034988474,
0.0014310543,
-0.011983282,
-0.005527881,
-0.010818805,
0.0040959804,
-0.014000806,
-0.0044277213,
-0.016573489,
0.034094807,
0.016587028,
0.004431106,
-0.0019041231,
-0.016411003,
-0.0045665107,
0.007731586,
0.0010629238,
-0.018266043,
-0.028461987,
-0.022463575,
-0.0069936328,
-0.010223025,
-0.0034460397,
0.018563932,
-0.01753486,
-0.0014691368,
-0.004481883,
0.03915893,
0.021217857,
-0.0006859075,
0.018144177,
-0.024264453,
0.035042636,
-0.010703711,
0.022341711,
0.013696146,
-0.007569101,
-0.014054968,
-0.0008268126,
0.011935891,
-0.0015969246,
-0.011042221,
0.012639993,
-0.014989258,
-0.024955016,
0.014230994,
-0.03171169,
-0.01600479,
0.0057309875,
-0.0073659946,
-0.010317809,
-0.011380733,
-0.028922362,
-0.013229001,
0.0043193977,
-0.004800083,
-0.026065331,
0.015273606,
-0.016505785,
-0.019945055,
-0.0026793128,
-0.03046597,
0.02102829,
0.0036220653,
0.032740764,
0.031820014,
-0.03144088,
-0.009133021,
0.031522125,
-0.006127045,
-0.004167068,
0.015002798,
0.018956603,
-0.008246123,
-0.0037066932,
-0.012193158,
0.018062936,
-0.017101565,
-0.024101967,
0.0071290373,
0.020161703,
0.02605179,
-0.0031803087,
0.002652232,
-0.042571116,
0.014217453,
0.004451417,
-0.00548726,
0.013398257,
-0.019213872,
-0.02762248,
0.02760894,
-0.013648755,
0.008070097,
0.0094106,
-0.040188,
0.034094807,
-0.03775072,
-0.01821188,
0.009945447,
0.0358009,
0.02697254,
0.0062049027,
0.0065095625,
0.0046545235,
-0.016045412,
0.031007588,
0.012037444,
-0.015287147,
0.04143372,
0.0010282265,
0.024156129,
0.012484278,
-0.01572044,
0.019741949,
-0.018618094,
-0.014786151,
-0.020581456,
-0.034419775,
-0.021813635,
0.02664757,
0.015788144,
-0.05058705,
0.014379938,
-0.008435689,
-0.003361412,
-0.014840313,
0.00423477,
0.005355241,
-0.007474318,
-0.008354446,
-0.0066111158,
-0.0035983697,
0.0025794522,
0.0027402448,
0.003385108,
-0.014610126,
0.0013997421,
-0.011590609,
-0.0024423553,
0.007068105,
0.026281977,
-0.024074888,
0.0005187678,
-0.02544247,
-0.017683804,
-0.0019261264,
-0.009789732,
-0.025550794,
-0.021326179,
-0.00564636,
0.024047807,
0.0005691213,
-0.0072982926,
0.022477116,
0.015002798,
0.009762651,
-0.005676826,
0.0024846692,
-0.014339317,
-0.021448044,
0.0105209155,
0.0051284386,
0.000074207914,
-0.002554064,
-0.0027690183,
-0.00068929256,
-0.0030550598,
-0.00847631,
0.006028877,
-0.01508404,
0.023912402,
-0.012179618,
-0.0015910007,
-0.011712473,
-0.008604944,
-0.012172848,
0.0085304715,
0.008205501,
-0.037777804,
-0.016221438,
0.01664119,
-0.0016062337,
0.013039435,
-0.043491866,
-0.009789732,
-0.04736443,
-0.010940668,
0.0071087265,
-0.016803676,
-0.013086827,
0.048258096,
0.01349981,
-0.012843099,
-0.02261252,
0.004928717,
-0.04137956,
-0.04703946,
-0.021461584,
0.0031464577,
0.00038018991,
-0.012037444,
0.012849869,
0.035096798,
0.007447237,
-0.0055312663,
-0.028489068,
-0.021150153,
0.0140414275,
-0.04614579,
0.032686602,
-0.00009229708,
-0.030303486,
0.0012499511,
0.0407567,
-0.0181848,
-0.0008458538,
0.022734385,
-0.0097017195,
0.010243337,
-0.014203913,
0.007406616,
0.02510396,
-0.01972841,
0.021272019,
-0.016763054,
0.009322587,
-0.016099572,
-0.008923144,
-0.010696941,
-0.020608537,
-0.015923547,
-0.019999217,
0.0011221633,
-0.038508985,
-0.031955417,
0.0026996236,
-0.020026298,
0.0056260494,
-0.004830549,
-0.014542423,
-0.010087621,
0.003009361,
-0.011671852,
-0.026458003,
0.016153734,
0.0013591208,
-0.027568318,
0.012788937,
-0.00911271,
-0.012030673,
0.0046003615,
0.003578059,
0.002963662,
0.006820992,
0.010202715,
-0.016438084,
-0.0069259307,
0.01160415,
0.0002970432,
0.007785748,
-0.02323538,
0.0028062544,
0.010290728,
0.021610528,
-0.029409816,
-0.00084839266,
0.0012482585,
-0.004143372,
0.007162888,
-0.024657127,
-0.010886507,
0.024535261,
-0.0028993448,
-0.033769835,
0.0048440895,
0.18469149,
-0.0015427629,
0.011895269,
0.05649068,
0.0023695754,
0.007636803,
0.009288736,
0.022382334,
-0.011597379,
0.010954209,
0.032497037,
-0.0139331035,
0.0006410548,
-0.0039131846,
0.030628456,
-0.01223378,
-0.017778587,
-0.01665473,
0.004678219,
-0.029626464,
-0.01255875,
-0.008889293,
-0.0049794936,
-0.015639199,
0.010615698,
-0.002459281,
-0.00013540432,
0.0023323393,
0.018049395,
0.005202911,
-0.014583045,
-0.02138034,
0.02165115,
0.006120275,
0.0097017195,
0.009031468,
-0.002310336,
-0.010405822,
0.024643585,
-0.012612912,
0.004708685,
-0.0018888902,
-0.02725689,
-0.012375955,
0.004041819,
0.0038184016,
-0.0076706544,
0.012612912,
-0.011448435,
0.02044605,
-0.022003202,
-0.0024338926,
0.04397932,
0.00012768204,
0.0066415817,
-0.01695262,
0.014583045,
0.01129949,
0.009552774,
0.022260468,
-0.0034138812,
0.013086827,
-0.008713268,
0.030303486,
-0.030682618,
0.019132629,
-0.017981693,
0.0061033494,
-0.024833152,
-0.025496632,
0.015395471,
-0.016058952,
-0.0048373193,
0.013513351,
-0.015314228,
-0.018496228,
0.0011035452,
0.028299501,
-0.0024338926,
0.020202324,
-0.0060458025,
-0.024955016,
-0.03423021,
0.0008445844,
-0.022531278,
-0.0030533674,
0.011272409,
-0.011387503,
-0.010250106,
-0.011123464,
-0.0057208324,
-0.0063673877,
-0.018672256,
0.015788144,
0.035367608,
-0.007399846,
-0.0062624495,
0.011874958,
-0.010148553,
-0.0010773105,
-0.03363443,
0.033823997,
-0.010737563,
0.028109936,
-0.012362414,
-0.011522907,
-0.033119895,
0.012992044,
-0.012822788,
-0.010710482,
0.0069462415,
-0.024900854,
0.0051318235,
-0.030330567,
0.0069293156,
0.029924354,
0.034419775,
-0.019024307,
0.010703711,
-0.012260861,
0.010527685,
-0.012653533,
0.004908406,
0.026782973,
-0.004173838,
-0.0006342846,
-0.0004174261,
-0.013120678,
-0.008029476,
-0.0121863885,
-0.00627599,
0.000009758632,
-0.0031312248,
-0.008367986,
-0.009864205,
-0.010744332,
-0.0034257292,
0.008131029,
0.0037540847,
-0.0049490277,
0.0005039579,
0.00054373295,
0.002838413,
-0.00097237225,
0.01632976,
0.0031549204,
-0.023343705,
0.0047865426,
-0.0018347284,
-0.004420951,
0.008395067,
-0.015327768,
0.0041907635,
-0.0023018734,
0.031495042,
-0.0021038444,
-0.015287147,
-0.037127864,
0.002633614,
-0.0055109556,
-0.023289543,
-0.0053315447,
0.023790538,
0.004908406,
0.00043075497,
0.035475932,
-0.17212597,
0.044737585,
0.00026573095,
-0.023289543,
0.023993645,
-0.016790135,
0.03073678,
-0.0066246563,
-0.001286341,
-0.011130234,
0.011766635,
-0.017913992,
-0.023343705,
-0.037859045,
0.017507778,
-0.013127448,
-0.0048203934,
0.03799445,
-0.0022037053,
0.01855039,
0.015612117,
0.0053484705,
0.013662295,
-0.008665876,
0.014515342,
0.005991641,
-0.0023289542,
0.036884136,
-0.0024525106,
0.010575077,
-0.0058190003,
-0.006438475,
0.03758824,
0.01883474,
-0.0112317875,
-0.028137017,
-0.013405027,
-0.0138789425,
0.012829559,
0.018645175,
0.027541237,
0.018387906,
0.01474553,
0.022978112,
-0.018591013,
0.008659106,
-0.007873761,
-0.040188,
0.015178824,
-0.009755881,
0.016194357,
-0.0065095625,
0.0029585843,
0.02068978,
-0.0037303888,
-0.008564323,
0.009634017,
-0.019010765,
0.013919563,
0.011130234,
-0.0140955895,
0.015544415,
0.017683804,
-0.0025625266,
-0.00067702157,
-0.0077925185,
-0.014962177,
0.023709295,
-0.005433098,
0.015774602,
-0.0097288,
0.02357389,
0.008909604,
0.0011788638,
0.02762248,
0.017196348,
-0.011597379,
-0.011157315,
0.010378741,
0.0048474744,
-0.018062936,
-0.021569908,
-0.0103652,
-0.010825575,
0.023722837,
0.00909917,
-0.0047323806,
0.019322196,
-0.002725012,
-0.00075276336,
0.026918378,
-0.014190372,
0.011055762,
-0.015761063,
0.01758902,
0.00033914548,
-0.0047222255,
0.00974234,
0.0112859495,
0.00046206723,
0.015788144,
-0.002010754,
-0.021800095,
0.023330163,
0.034419775,
-0.0065027922,
0.005835926,
0.005250302,
0.02514458,
-0.01788691,
-0.0022070904,
0.00847631,
-0.000537809,
0.029139008,
-0.014528883,
0.028895281,
-0.0013972033,
-0.016803676,
0.020351268,
-0.015652739,
0.04332938,
-0.0000783864,
0.028055774,
0.019863812,
-0.02196258,
-0.0038962592,
-0.11086905,
-0.014637207,
-0.00075318647,
-0.011245328,
-0.00911271,
0.010399051,
0.014149751,
0.003400341,
-0.009058549,
0.017778587,
0.008726808,
-0.011346881,
0.0063267667,
-0.012118686,
0.03320114,
0.014366398,
-0.021407422,
0.0077925185,
-0.020757481,
0.021529285,
0.0002331493,
-0.0079820845,
0.0037506996,
-0.0016561641,
-0.0019345891,
0.009254885,
-0.019281574,
0.02068978,
0.0077451267,
0.028326582,
0.009078859,
0.0066145007,
-0.0014835235,
-0.0079550035,
-0.023465568,
-0.010453213,
-0.015585037,
-0.011441665,
0.0085033905,
-0.013086827,
0.00204122,
-0.00068802317,
0.009911596,
-0.012599371,
0.02949106,
-0.005466949,
-0.025239363,
0.029951435,
0.00690562,
0.0013870479,
0.006485867,
-0.0140414275,
-0.031170074,
-0.009166872,
0.024440479,
-0.0031853865,
-0.00878774,
-0.007379535,
0.0015249911,
-0.025699738,
-0.019240953,
0.0040959804,
-0.025009178,
0.017142186,
0.03320114,
-0.00087589666,
-0.011360422,
-0.027094403,
0.0056700557,
-0.032605357,
-0.014190372,
-0.010195944,
0.0070545645,
0.018333744,
-0.0074201566,
-0.012788937,
-0.03206374,
-0.008489851,
0.015896466,
-0.010195944,
0.010683401,
-0.017521318,
0.020107541,
0.0023086437,
-0.026200734,
0.026241357,
0.032172065,
0.016722433,
0.0051013576,
-0.00910594,
-0.008510161,
0.03479891,
0.012389495,
-0.010608928,
-0.006973322,
0.029978516,
-0.0039097997,
-0.011008371,
0.035259284,
-0.0039910423,
-0.024061346,
-0.018022314,
-0.055949062,
0.016668271,
0.011868188,
0.009160101,
-0.019186791,
-0.0049422574,
0.02664757,
0.017358834,
0.0073253736,
0.023303082,
-0.016045412,
0.031467963,
-0.021461584,
-0.015463172,
-0.021813635,
-0.011143775,
0.037913207,
0.028624471,
0.018333744,
0.019917974,
-0.001512297,
0.0120780645,
0.0051961406,
0.024521722,
0.000797616,
-0.0030635225,
-0.018739957,
0.022991652,
-0.014718449,
-0.018266043,
0.0067025134,
-0.017507778,
0.005903628,
0.02105537,
-0.0066652773,
-0.0026386916,
-0.024223832,
-0.0020987669,
0.024968555,
-0.0052469173,
-0.006902235,
-0.020771021,
-0.012741546,
-0.023357244,
0.0044412613,
-0.007630033,
-0.02012108,
0.007189969,
0.017372373,
-0.00088182057,
0.041217074,
0.015341309,
0.0112588685,
-0.04460218,
-0.017223429,
0.020297106,
0.017981693,
0.00011562259,
0.002716549,
-0.02794745,
0.020202324,
0.010845886,
-0.009634017,
-0.010392281,
-0.031278398,
-0.041975338,
0.010229796,
-0.00911271,
-0.0023374169,
-0.03046597,
-0.02699962,
-0.00054415606,
0.009898055,
0.018266043,
0.0008090408,
0.0026623872,
-0.023181219,
0.00046714488,
-0.0076029524,
0.024047807,
0.0010984675,
0.0059679453,
-0.04016092,
0.0369383,
0.0027944066,
0.0013227309,
-0.012653533,
0.0040282784,
-0.0030872184,
0.020324187,
0.0071764286,
0.0011128542,
0.0076977354,
-0.008699727,
-0.0076029524,
0.022991652,
0.013046206,
0.0021156925,
0.0057614534,
-0.0022443265,
0.007332144,
-0.000088277266,
-0.009749111,
-0.016451623,
-0.02449464,
-0.010324579,
-0.034446858,
-0.021136614,
-0.009254885,
0.021475125,
0.027920369,
-0.0025828374,
-0.006770216,
0.00089197594,
0.0029382736,
0.006113505,
-0.014298695,
0.022368792,
-0.01098806,
0.032497037,
-0.0020970744,
0.031901255,
0.02984311,
0.002621766,
0.008070097,
-0.011786945,
0.027717263,
-0.020215863,
0.02667465,
-0.021041831,
0.002625151,
0.015232985,
-0.014447641,
0.0033478716,
0.0018161103,
-0.0021580062,
0.012822788,
0.029409816,
-0.025780981,
0.068947874,
0.0035103569,
0.00034422317,
-0.0066618924,
0.018807659,
0.0015072193,
0.0024423553,
0.023939483,
-0.017101565,
0.002701316,
0.0044378764,
-0.0072915223,
0.01098806,
-0.036775813,
-0.020974128,
0.024156129,
-0.0069259307,
0.028001612,
-0.027893288,
-0.02949106,
0.02228755,
-0.017995233,
-0.0021004595,
0.001756871,
-0.016573489,
-0.008036246,
0.03138672,
-0.0029721246,
0.015449632,
-0.020594995,
-0.010900048,
0.04389808,
-0.037452832,
-0.02005338,
-0.0013142681,
-0.00846277,
0.015043419,
0.0042923167,
-0.01192235,
0.0075081694,
-0.0049964194,
0.030980507,
-0.013594593,
-0.018414987,
-0.024955016,
-0.016735973,
-0.0017060944,
-0.0033884929,
-0.027690182
] |
BACKGROUND There is a widespread interest in developing renewable sources of islet-replacement tissue for type I diabetes mellitus. Human mesenchymal cells isolated from the Wharton's jelly of the umbilical cord (HUMSCs), which can be easily obtained and processed compared with embryonic and bone marrow stem cells, possess stem cell properties. HUMSCs may be a valuable source for the generation of islets. METHODOLOGY AND PRINCIPAL FINDINGS HUMSCs were induced to transform into islet-like cell clusters in vitro through stepwise culturing in neuron-conditioned medium. To assess the functional stability | [
-0.025983606,
-0.016555572,
0.012007777,
-0.0016347796,
-0.0037000708,
-0.009587605,
-0.009321651,
0.005904156,
-0.020837415,
-0.021169856,
0.005225976,
0.011927991,
-0.014427949,
-0.0013239471,
-0.013304298,
0.024893198,
0.039281253,
0.0066454997,
-0.009321651,
0.011901395,
-0.032871787,
-0.001129469,
0.0001062773,
-0.0009649106,
-0.017060883,
0.022512918,
0.024454376,
-0.013975829,
-0.010571631,
-0.030850545,
0.0106647145,
0.0070942957,
-0.015691224,
-0.008470602,
-0.013151375,
-0.00045627556,
0.0013638401,
-0.0035438233,
0.030318638,
-0.0024650516,
0.017898634,
0.00042053813,
0.0009300043,
-0.013909341,
-0.007985238,
0.002927145,
-0.007333653,
-0.020744331,
0.00916208,
0.022180477,
0.020212425,
0.012586224,
-0.012080913,
-0.0009873504,
-0.031196283,
-0.010192648,
0.009315003,
0.017007692,
0.0186566,
-0.014334865,
0.015239106,
-0.0020395268,
-0.019321483,
0.003799803,
0.018802876,
0.009288408,
-0.042712048,
0.0007575504,
0.017087478,
0.0041688127,
0.026542107,
0.0040125656,
0.0016763348,
-0.008357572,
0.02063795,
-0.008550388,
-0.0006490915,
-0.0076993387,
0.005156163,
0.00058509654,
0.0060604033,
-0.02708731,
-0.02324429,
0.03829723,
0.0006224962,
0.015411975,
-0.021981014,
0.0030950278,
0.0025863927,
-0.011801663,
0.009733879,
0.030478211,
-0.0013580223,
-0.004195408,
-0.007865559,
0.0010671363,
-0.019653924,
0.03454729,
0.009467926,
-0.014786985,
-0.012752445,
0.01599707,
-0.010272433,
-0.022685789,
-0.023390563,
-0.00013484647,
0.029440993,
-0.009474575,
0.037419584,
0.007227272,
-0.006854938,
0.036914274,
-0.022978337,
-0.015079534,
0.01928159,
0.01147587,
0.022672491,
0.0154651655,
0.00672861,
0.0021725034,
0.011296352,
0.014826878,
-0.00048785747,
-0.033909004,
0.02555808,
0.016688548,
-0.012918666,
0.00054645026,
-0.02341716,
-0.006356276,
0.005186083,
-0.013158023,
0.015132724,
0.013297648,
-0.01249979,
0.008151459,
-0.014414651,
-0.011635442,
-0.0006091985,
-0.02906866,
-0.021821441,
0.026927738,
0.0045344983,
0.0056016343,
-0.007652797,
0.0112697575,
0.03178138,
-0.00051569944,
0.0017403298,
0.025212342,
0.0108442325,
-0.02477352,
0.012566278,
-0.004122271,
0.01476039,
0.0052326247,
0.015159319,
0.025943711,
-0.01266601,
0.0070942957,
-0.00025161644,
-0.025996903,
0.0017203833,
-0.0034972816,
0.021010285,
0.023789493,
-0.008410763,
-0.017579492,
0.013749769,
0.01051844,
-0.014361461,
0.021568786,
-0.005066404,
0.022765575,
-0.021409214,
0.010877476,
-0.011901395,
0.0071341884,
-0.04765877,
-0.023842683,
-0.025278829,
0.026129879,
0.0051195947,
0.014427949,
-0.008902776,
-0.019294888,
0.005737935,
-0.016927907,
0.0008701649,
-0.017180562,
-0.0028490212,
0.0055151996,
-0.011775068,
-0.02362992,
-0.6497763,
-0.047126867,
0.028244205,
0.005096324,
0.013523709,
0.016542275,
0.017286943,
0.00043591353,
-0.010564982,
-0.010378814,
0.0058941827,
0.010538386,
-0.00028465278,
-0.0055451193,
-0.0075131715,
-0.010259136,
-0.000862685,
-0.03715363,
0.023510242,
-0.013563601,
-0.025571378,
0.0066820686,
-0.005614932,
0.011296352,
0.010997156,
0.0031581915,
0.019866686,
-0.0013131428,
-0.012619468,
0.013882745,
-0.005817721,
0.018390648,
-0.010185999,
0.003444091,
0.05241933,
0.012845528,
-0.037818514,
0.0014211861,
-0.015571547,
0.02630275,
-0.0029670377,
0.0070078606,
0.019201804,
0.0058941827,
-0.029547375,
0.023191098,
0.008217947,
0.0020777576,
-0.010983857,
0.018284267,
0.012759094,
0.018962447,
-0.013736471,
-0.0033410343,
0.018191183,
-0.015784308,
0.028802706,
-0.014919962,
0.021981014,
0.01599707,
0.009301705,
0.043988623,
-0.010884126,
-0.018802876,
0.024294805,
0.02698093,
0.00033306453,
0.006881533,
0.029201636,
-0.030850545,
0.01662206,
0.03425474,
-0.019879984,
0.017778955,
0.01385615,
0.025411807,
0.007606255,
-0.021808144,
0.0020960418,
-0.0027775464,
0.00814481,
-0.002057811,
-0.000040698076,
-0.004963347,
0.012586224,
-0.0007130864,
-0.0015308918,
0.014241782,
-0.028297396,
0.02347035,
-0.0037333148,
0.015225807,
-0.0015433583,
-0.07170092,
-0.015026343,
0.026449023,
-0.015903987,
0.0043682777,
0.008583632,
-0.023789493,
-0.009507819,
-0.001968052,
0.009002508,
-0.015358784,
0.02081082,
-0.007639499,
-0.051993806,
0.003670151,
0.03579727,
-0.0384568,
0.015797606,
0.006130216,
-0.0026645162,
0.002782533,
0.007639499,
-0.021169856,
0.008071673,
-0.0016580506,
0.0037100438,
-0.03284519,
0.002750951,
-0.012858826,
0.0049101566,
0.004414819,
0.011681984,
0.015185915,
0.004710692,
-0.018962447,
0.0028656432,
-0.015172617,
-0.0033992114,
-0.017313538,
0.007619553,
-0.023217695,
0.03694087,
0.0026877872,
0.0034806596,
-0.0139625305,
0.019747008,
-0.012938612,
-0.008517144,
0.009088943,
0.002830737,
-0.028297396,
-0.0042785183,
-0.001653895,
-0.008025131,
-0.0054553603,
0.011549008,
-0.013058291,
-0.0039527263,
-0.016076857,
-0.008902776,
0.015425272,
0.011608847,
-0.0152657,
0.0015641359,
-0.026515512,
0.023789493,
-0.0020611356,
-0.031089902,
0.03874935,
-0.019002339,
0.00320972,
0.006881533,
-0.021608679,
-0.016808229,
-0.008104917,
-0.02493309,
-0.029706948,
-0.014866771,
0.0058443164,
0.0074001416,
0.03199414,
-0.019148614,
-0.004391548,
-0.013989126,
-0.015917284,
-0.018244375,
0.0058675874,
0.008849585,
-0.022925146,
-0.00050073955,
-0.019254996,
0.010026427,
-0.0027925062,
0.020757629,
0.0070211585,
-0.003540499,
0.026050093,
-0.023310779,
0.019853389,
0.0047173407,
0.0175263,
0.014148698,
-0.031169688,
-0.005701367,
0.0022157207,
0.0047372873,
0.014906664,
0.030584592,
-0.00865012,
0.018696494,
-0.0013214538,
0.016236428,
-0.042153545,
-0.008690014,
-0.019321483,
0.020239022,
0.035478126,
0.0036834485,
-0.007187379,
-0.01934808,
0.00049575296,
0.019919878,
0.0033177633,
-0.021808144,
-0.016821526,
-0.0076993387,
-0.0023802791,
0.0049101566,
0.0079054525,
0.0139625305,
-0.013556953,
-0.010106212,
0.014481139,
0.010019778,
0.0051727854,
-0.015970476,
-0.021023583,
0.013350839,
0.0130051,
0.015957179,
0.004218679,
-0.0022971688,
0.0053589526,
0.006023835,
-0.029308017,
0.022486323,
0.011914693,
0.023895875,
0.009128836,
0.01182161,
0.015531654,
-0.011017102,
-0.016489085,
0.02295174,
-0.0059241024,
-0.011721877,
0.01945446,
-0.03760575,
0.005245922,
-0.0020046206,
0.0017968448,
0.01142268,
-0.019747008,
-0.01040541,
-0.0018467109,
0.028456967,
0.011615496,
0.0068748845,
0.0046674744,
-0.0025182422,
-0.0036202848,
0.012380111,
0.0012998452,
0.014880069,
-0.010072969,
-0.023164503,
-0.0029969576,
-0.01912202,
0.009973236,
0.019826794,
-0.031089902,
0.0120343715,
0.011748472,
0.037286606,
-0.0034241446,
0.012812285,
-0.010870827,
-0.019720413,
-0.033669647,
0.0054586846,
0.021754952,
-0.0140290195,
-0.0035737432,
-0.028323991,
-0.019042233,
-0.007107593,
-0.0030617835,
0.0025697707,
0.0012757431,
0.026316047,
-0.0064659817,
-0.0018251023,
-0.0068349913,
0.0050231866,
0.0048602903,
0.018696494,
0.01181496,
0.022087393,
-0.0032313287,
-0.003856318,
-0.007719285,
0.02991971,
0.004175462,
-0.013816257,
-0.0012075927,
0.004856966,
-0.03726001,
-0.029015468,
-0.022459729,
0.011681984,
0.011655389,
0.009687337,
0.011628794,
0.01097056,
0.004597662,
0.01747311,
0.000012752237,
0.009534414,
-0.0305314,
-0.020504974,
-0.011622145,
0.037818514,
0.031462237,
0.00062956056,
0.010717905,
0.0023752924,
0.000024985035,
-0.0031482184,
-0.040238686,
-0.0015724469,
-0.009747176,
0.014454544,
-0.0063828714,
0.021422511,
-0.009567658,
-0.009454628,
0.010392113,
-0.036063224,
-0.017087478,
0.012685956,
-0.0072804624,
0.00065033813,
-0.010704607,
0.024627246,
0.034174956,
0.035212174,
0.0036502045,
0.037073843,
0.016888013,
-0.03098352,
0.005249247,
-0.015531654,
0.0016272997,
0.0040557827,
0.007619553,
-0.0020312157,
-0.02957397,
0.011808312,
0.010837584,
0.029600566,
0.0026578675,
0.015704524,
0.03529196,
0.0071275397,
-0.0073070577,
-0.0065224967,
-0.029414399,
-0.0008759826,
0.012060967,
-0.008616876,
-0.014401353,
0.027738895,
-0.04263226,
0.0072472184,
-0.018058207,
0.013503762,
0.012393408,
-0.010272433,
0.0036801242,
-0.008011833,
-0.013164672,
-0.004607635,
-0.022592705,
0.010525089,
-0.0023836035,
-0.02442778,
-0.010471898,
-0.00320972,
-0.0024617272,
-0.02668838,
-0.0076926895,
0.028935684,
0.0021076773,
-0.026887845,
0.015877392,
-0.0021990987,
0.010451952,
0.021023583,
0.0040557827,
0.005202705,
0.018962447,
0.0119878305,
-0.026728274,
0.0008818003,
-0.013158023,
-0.009022455,
0.014002424,
-0.0021558814,
-0.0175263,
-0.0054786312,
-0.001476039,
0.0035272012,
0.011342894,
-0.0061834063,
-0.00008799303,
-0.015518356,
0.0039494014,
0.025172448,
0.00021546346,
-0.01662206,
-0.004840344,
-0.009760474,
-0.044946052,
-0.012606171,
-0.013922638,
0.011416031,
0.0032296665,
-0.0071474863,
0.00978707,
-0.009414735,
-0.011010453,
0.012067616,
-0.00455112,
0.007865559,
-0.001750303,
0.013949233,
0.020079449,
-0.016755037,
-0.0034141713,
0.017513003,
-0.005219327,
0.0007891323,
-0.03433453,
0.036329176,
0.0051761097,
-0.027047418,
-0.008736555,
0.009002508,
-0.013510411,
-0.028589945,
-0.008045077,
-0.0034474153,
0.047578987,
-0.01238676,
-0.021927822,
-0.012745796,
-0.028855897,
0.019933175,
0.007599606,
-0.0044314414,
0.002566446,
0.021289535,
0.009248515,
0.014454544,
-0.024693733,
-0.0026445698,
-0.039334446,
-0.015757713,
0.024308102,
0.021808144,
-0.0032196932,
-0.021116666,
0.006293112,
0.009826962,
-0.010146106,
0.0011120158,
-0.014946557,
0.011515764,
-0.04116952,
0.032419667,
0.044041812,
0.030079281,
-0.0024866604,
0.0029171717,
0.017539598,
0.00066322024,
0.012599522,
-0.005558417,
0.020877307,
-0.019148614,
0.021223048,
0.0033792648,
0.009620849,
0.000677349,
-0.006203353,
0.020970391,
0.022207074,
-0.0052957884,
-0.023536839,
-0.0024966334,
-0.039041895,
-0.035026006,
-0.008749853,
-0.0003222602,
-0.017619384,
-0.04252588,
-0.008178053,
0.018164588,
-0.007380195,
-0.0019547543,
0.008630174,
0.031302664,
-0.025531486,
0.038190845,
0.0061767576,
0.008683365,
0.007985238,
-0.010505143,
-0.0031914357,
-0.033722837,
0.01611675,
0.01934808,
-0.013882745,
0.031807974,
-0.037286606,
0.011263108,
0.023390563,
-0.03704725,
-0.0073535996,
0.00016300008,
-0.031488832,
-0.004856966,
-0.011056995,
-0.03082395,
-0.016755037,
-0.011170025,
0.005784477,
-0.021515595,
0.010877476,
-0.0150396405,
0.0018699819,
0.023723004,
-0.007220623,
0.0072006765,
-0.0067585297,
0.024893198,
0.056116078,
0.0031066632,
-0.020877307,
-0.009800367,
0.010525089,
-0.009707283,
0.029387804,
0.016050262,
0.012632766,
-0.038004678,
0.012087562,
0.017233752,
-0.0051162704,
-0.021768251,
-0.000697711,
0.021223048,
0.0044879564,
-0.0027326667,
-0.016608763,
-0.021422511,
0.0016605438,
-0.015505058,
0.008051726,
-0.0033094522,
0.0039194818,
-0.011801663,
0.04835025,
0.0018400621,
0.00206446,
0.008111565,
-0.0014735457,
-0.023363968,
-0.043962028,
-0.041435473,
-0.007459981,
0.008151459,
0.005644852,
-0.029201636,
0.0009574307,
0.031568617,
-0.017207157,
0.0018832795,
0.0060637277,
-0.013257756,
0.028403778,
0.0036302581,
0.008949317,
0.028563349,
-0.0080849705,
-0.010618173,
-0.019747008,
-0.009541063,
0.015518356,
-0.02968035,
-0.014228484,
0.032792002,
0.030584592,
0.007832315,
0.010358868,
-0.017459812,
-0.012180646,
-0.04332374,
-0.028722921,
-0.014786985,
-0.029946305,
0.0024384563,
0.014095508,
0.010485196,
0.013184618,
-0.020159235,
0.007991887,
0.024520865,
0.027552728,
0.0027542755,
0.0367547,
0.019986365,
0.029893113,
-0.006283139,
0.0005024018,
0.0130051,
-0.030797355,
0.002338724,
-0.017034288,
-0.02477352,
0.023137908,
0.00345074,
0.003959375,
-0.019653924,
0.00018824484,
0.0072073257,
0.023124611,
0.033270717,
0.0022074096,
-0.014840175,
0.014627414,
-0.01385615,
-0.020398593,
0.0072139744,
-0.008736555,
-0.0030584591,
0.007120891,
-0.013144726,
-0.017672574,
-0.016755037,
-0.014002424,
-0.028058039,
0.02595701,
-0.019095423,
0.019401269,
-0.028643135,
-0.00876315,
-0.013696578,
-0.0021907876,
0.01430827,
-0.0175263,
-0.027526133,
0.02380279,
0.014667306,
0.033643052,
-0.015651332,
0.009062348,
-0.027871871,
-0.014122102,
-0.015505058,
0.01385615,
-0.018231075,
0.03308455,
0.00090008456,
0.0009067334,
-0.031648405,
0.011788365,
-0.051036377,
-0.03811106,
-0.0023703058,
0.0150396405,
-0.007366897,
-0.002371968,
0.003186449,
0.00027904284,
0.00661558,
0.0074001416,
-0.015957179,
-0.0095211165,
0.039228063,
-0.0048436685,
0.016688548,
0.013656685,
-0.03749937,
-0.012878773,
0.028111229,
-0.012945261,
0.002573095,
0.0033909003,
0.007047754,
0.02991971,
-0.009833612,
0.028191015,
0.014042317,
0.008729906,
0.0052226516,
-0.036435556,
-0.011808312,
0.019308185,
-0.014042317,
0.0062133265,
-0.025571378,
-0.014268377,
-0.009188675,
0.0014386394,
-0.0055384706,
-0.002047838,
0.013271053,
-0.010033076,
0.019520948,
-0.027898466,
-0.0036734755,
-0.0030268773,
0.007486576,
-0.0055850125,
-0.015611439,
0.0180981,
0.02018583,
-0.005043133,
0.005840992,
-0.011662038,
-0.015810905,
-0.015239106,
-0.0039992677,
-0.03829723,
0.008184703,
0.010166053,
0.003816425,
0.0005331526,
0.018364053,
0.0005319059,
-0.0299729,
-0.029334612,
0.008463954,
0.00054645026,
-0.012739147,
-0.0007995211,
0.006216651,
-0.005212678,
-0.005452036,
0.010019778,
-0.031940952,
-0.009986534,
0.012233837,
-0.017114073,
-0.0012865475,
-0.005508551,
0.18914576,
-0.017898634,
0.020717736,
0.02002626,
0.0023869278,
-0.006067052,
0.009793718,
0.008410763,
0.0008693338,
0.007832315,
0.002847359,
-0.011688633,
-0.018483732,
-0.011176674,
0.020571463,
-0.010079618,
-0.00062000286,
0.0027642488,
-0.010564982,
-0.022446431,
-0.0069413725,
-0.020544866,
0.019401269,
-0.0051594875,
0.028882492,
-0.017845444,
-0.015026343,
0.009361545,
0.035717484,
0.026369236,
-0.0333505,
0.015066236,
-0.006848289,
0.011356192,
0.021954417,
-0.019215101,
0.00047580648,
-0.011017102,
0.019188507,
0.008344274,
0.008178053,
-0.011775068,
-0.017060883,
0.016608763,
0.0057778284,
0.01957414,
-0.007998535,
0.007971941,
0.016555572,
0.002234005,
-0.025292128,
0.007027807,
0.01843054,
0.004218679,
0.01849703,
-0.0140290195,
0.018523624,
0.028536754,
0.010318975,
0.008776448,
-0.026794761,
0.0025282155,
-0.016036965,
0.033323906,
-0.019042233,
0.012207242,
-0.009454628,
-0.011688633,
0.0014893366,
0.00088761805,
-0.014786985,
-0.014095508,
-0.016036965,
0.009793718,
-0.017406622,
-0.009002508,
0.036781296,
0.010352219,
-0.00217749,
-0.0023071421,
0.0038596424,
0.0036734755,
-0.027286775,
-0.00027488734,
-0.0025232288,
-0.03659513,
0.022592705,
0.014414651,
-0.015013046,
-0.014800283,
0.0018566842,
0.023230992,
-0.0020827441,
-0.024574054,
0.005282491,
-0.0020993662,
0.015731119,
0.0032994791,
0.0012109171,
-0.016435893,
-0.016382704,
0.053616118,
0.019401269,
0.005648176,
-0.0011893085,
-0.0067950985,
-0.011721877,
-0.008470602,
-0.017898634,
0.004268545,
0.00627649,
-0.02364322,
-0.0012325258,
-0.021528892,
-0.0032529372,
0.015518356,
0.012918666,
-0.02041189,
0.024919793,
-0.012054319,
0.01860341,
-0.01968052,
0.0050929994,
0.0076926895,
-0.006921426,
0.011881449,
0.008729906,
0.016435893,
-0.0063529518,
-0.02538521,
-0.006751881,
-0.026648488,
0.0014461193,
0.027419752,
0.01667525,
-0.0010995494,
-0.0058775605,
0.009374842,
-0.0186566,
0.008656769,
-0.02249962,
-0.021050178,
0.0083775185,
-0.0026163124,
0.008630174,
-0.024733625,
0.03523877,
0.0044081705,
-0.0037698834,
-0.04082378,
-0.011156728,
-0.030451614,
0.016435893,
-0.017885337,
0.037180226,
0.0007799902,
-0.0299729,
-0.039494015,
-0.015850797,
0.015305594,
-0.014587521,
0.018736387,
0.009168728,
0.0033443586,
-0.009082294,
-0.01933478,
-0.16808228,
0.0013247782,
0.027393157,
-0.03172819,
0.025810735,
-0.0057811528,
-0.01272585,
-0.010564982,
-0.00008253892,
0.017792253,
0.03997273,
-0.011575603,
-0.039892945,
-0.004175462,
0.009022455,
-0.012798986,
0.00042012258,
0.032313287,
0.0016090155,
-0.0027143825,
0.018137993,
-0.0033293988,
0.008995859,
-0.011482519,
0.008091619,
-0.015199212,
0.012373462,
-0.008051726,
-0.022220371,
-0.022140585,
0.00094330194,
0.0069413725,
0.031036712,
-0.0050630798,
0.010325624,
0.0037898298,
0.0058609387,
-0.001000648,
0.02369641,
0.013949233,
0.037419584,
0.009507819,
0.00876315,
0.006422764,
-0.00548528,
0.022353347,
-0.0048303707,
-0.021542192,
0.026169773,
-0.010717905,
0.0175263,
-0.000721813,
-0.014866771,
0.031036712,
0.011728526,
0.024800114,
0.008696662,
-0.001628962,
-0.0035737432,
0.0023819413,
0.008716608,
-0.009999832,
0.001758614,
-0.019441161,
0.014587521,
-0.04167483,
0.008098268,
-0.0026246235,
-0.018550219,
-0.0029238204,
-0.03420155,
-0.0008398296,
0.013284351,
-0.02013264,
0.030478211,
0.018071504,
0.007573011,
0.0068150447,
-0.0068283426,
-0.0038463448,
-0.014494437,
0.008503846,
-0.018776279,
-0.0034939572,
-0.0022290184,
0.016010368,
0.0054719825,
0.0013364137,
-0.0065690386,
0.002702747,
0.020757629,
-0.02968035,
-0.010205945,
-0.0130051,
0.009926694,
0.01679493,
-0.013124779,
-0.012931963,
0.0047040433,
0.0038862377,
0.02013264,
-0.0039294553,
-0.015917284,
0.019387972,
0.017433217,
0.0052957884,
-0.0333505,
-0.003926131,
0.02861654,
-0.010172701,
-0.017406622,
-0.0023536838,
0.020770928,
0.031701595,
0.008550388,
0.022738978,
-0.0075198202,
-0.008244542,
0.02567776,
-0.0373132,
0.03739299,
0.013736471,
-0.01656887,
0.018417243,
0.014680604,
-0.0096341465,
-0.12510428,
-0.01611675,
0.005269193,
0.015598142,
-0.023031527,
0.022459729,
0.0008851247,
0.0030019442,
-0.02776549,
0.026103284,
-0.020318806,
-0.036621723,
0.00684164,
-0.00582437,
0.04760558,
-0.017313538,
-0.00011001727,
0.011914693,
-0.020784225,
0.032924976,
0.013935936,
-0.01589069,
-0.025345318,
-0.02776549,
0.014161996,
0.03382922,
-0.041940782,
0.04835025,
0.029015468,
0.03534515,
0.0048303707,
0.00016383118,
0.02256611,
-0.006219975,
-0.018005015,
-0.00955436,
-0.028350586,
-0.022645896,
0.018909257,
-0.024281505,
0.014228484,
0.01266601,
0.019414566,
-0.008636823,
-0.005112946,
0.0045710667,
-0.024680436,
-0.017539598,
0.012759094,
-0.019294888,
-0.022592705,
-0.015651332,
-0.015013046,
0.00006892961,
0.02272568,
-0.020850712,
0.019720413,
0.0083775185,
-0.0021874632,
-0.030664377,
-0.0010771095,
-0.008470602,
-0.035531316,
-0.00024226653,
0.033164337,
-0.0035604455,
-0.018789578,
-0.0125729265,
-0.0014311594,
-0.020371998,
-0.004710692,
0.00010243345,
-0.009454628,
-0.009481223,
-0.006342978,
-0.007506523,
0.004484632,
0.008882829,
-0.015731119,
-0.010990507,
-0.009800367,
-0.025531486,
0.012632766,
-0.0041422173,
-0.0013763066,
-0.000774588,
0.03704725,
-0.006180082,
0.0012790676,
-0.020478379,
-0.0067884494,
0.023044825,
-0.011781717,
-0.009148782,
0.003879589,
0.0038596424,
-0.0037166928,
0.0037599101,
0.023935767,
0.018709792,
-0.0047638826,
0.00054728135,
-0.052685283,
0.015744416,
-0.0069879144,
-0.012506438,
-0.0006781801,
-0.03162181,
-0.016396001,
0.0022838712,
0.02539851,
-0.00078331464,
-0.01882947,
0.005575039,
-0.019653924,
0.006000564,
-0.031648405,
-0.005096324,
0.02171506,
-0.017167265,
0.013271053,
0.0061734333,
-0.0013322581,
-0.019866686,
-0.012114158,
0.011954586,
-0.010053022,
0.011828259,
-0.021754952,
0.030265449,
0.008204649,
-0.019294888,
0.014680604,
-0.038270634,
-0.020292211,
0.015239106,
-0.0015317228,
-0.00559831,
0.0057146642,
0.020983689,
0.021023583,
0.019853389,
-0.0090955915,
-0.025318723,
0.011209917,
0.0243214,
-0.0099931825,
0.003597014,
-0.028802706,
0.032206904,
-0.007858911,
-0.01606356,
0.049068324,
0.02640913,
0.0075198202,
-0.024866603,
-0.012632766,
0.00842406,
0.016236428,
0.009175378,
-0.02279217,
0.0002580575,
0.027472941,
0.00579445,
0.0025298777,
0.009075645,
-0.01549176,
-0.030797355,
-0.022938443,
0.01119662,
0.00011427667,
-0.00080533884,
-0.029627161,
0.0030218905,
0.003816425,
0.018231075,
0.014707199,
0.0012325258,
-0.005282491,
0.026808059,
0.004105649,
0.023377266,
0.0086700665,
0.0022955067,
-0.03404198,
0.02272568,
0.027393157,
-0.004175462,
-0.000592992,
0.030557996,
0.011376139,
-0.01017935,
0.003879589,
0.02425491,
0.0048104245,
0.0018483731,
-0.0024550783,
0.017047586,
-0.010604875,
0.007114242,
0.0050364845,
0.039946135,
-0.0080849705,
0.0058376677,
0.020824118,
-0.025278829,
-0.02341716,
0.004790478,
-0.017566193,
-0.03654194,
-0.013151375,
-0.017792253,
0.008955967,
0.012592874,
0.00074965495,
0.0047505847,
-0.023217695,
-0.0034075223,
0.0028506834,
-0.009068997,
-0.003090041,
0.043962028,
0.0074666296,
0.0027127203,
0.011296352,
0.001194295,
-0.0039161574,
0.028430372,
0.012699255,
-0.0063363295,
0.021063475,
0.004687421,
0.0243214,
-0.0012923653,
-0.01888266,
-0.028536754,
-0.0025464997,
-0.025464997,
0.0014968165,
0.008131512,
-0.0151061285,
0.084732614,
0.016888013,
-0.014215186,
0.009920046,
-0.027060715,
0.021608679,
0.0024800114,
0.009514468,
-0.016462488,
0.0024168475,
0.023789493,
-0.018084802,
0.018749684,
-0.034520697,
-0.03313774,
0.020598058,
0.013031696,
0.008503846,
-0.014002424,
-0.009793718,
0.021462405,
-0.017486408,
0.0018600086,
0.006160136,
-0.024946388,
-0.0053656013,
0.030238852,
-0.031063307,
0.008131512,
-0.01775236,
0.007227272,
0.017739063,
-0.03630258,
0.005016538,
0.004783829,
-0.009334949,
0.00051777717,
-0.029201636,
0.0041887593,
0.018177886,
-0.00568142,
0.03420155,
-0.01797842,
0.0045112274,
-0.0109572625,
-0.028536754,
-0.025145853,
-0.006283139,
-0.0064327377
] |
OBJECTIVE To determine whether the perioperative use of hydroxyethyl starch 6% and albumin 5% in elective joint arthroplasties are associated with an increased risk for perioperative complications. DESIGN Retrospective cohort study of population based data between 2006 and 2013. SETTING Data from 510 different hospitals across the United States participating in the Premier Perspective database. PARTICIPANTS 1,051,441 patients undergoing elective total hip and knee arthroplasties. EXPOSURES Perioperative fluid resuscitation with hydroxyethyl starch 6% or albumin 5%, or neither | [
0.0052064923,
0.0006583305,
0.0049291244,
-0.034754504,
-0.004133781,
0.02152106,
-0.00029052593,
0.008387866,
-0.018272849,
-0.0026400057,
0.0011537493,
0.002469575,
-0.0006274191,
0.015519223,
-0.022777569,
-0.006950901,
0.036251623,
0.008782196,
-0.008615107,
-0.006833939,
-0.008341081,
0.016615327,
-0.01710991,
0.009757996,
-0.0040535782,
0.002756968,
0.02304491,
-0.023125112,
0.013901802,
-0.015666261,
0.008935918,
-0.004407807,
-0.027830338,
-0.00049625424,
-0.010025338,
-0.004631706,
0.00025251321,
0.005764569,
0.008454702,
0.010793948,
0.009363665,
0.0027820312,
0.0012247622,
-0.013139877,
-0.00016291175,
-0.0039934264,
0.0015296995,
-0.004578238,
-0.0011955216,
0.029487861,
0.021200249,
0.012077191,
0.002482942,
0.0064429506,
-0.0028020819,
0.009149792,
-0.014690462,
0.01735052,
0.012966104,
-0.019181814,
0.010700378,
0.018767433,
-0.022216149,
0.0017661303,
-0.014436487,
-0.010526605,
-0.029273987,
0.0027068413,
0.024876205,
-0.0020702323,
0.01891447,
0.033551466,
-0.016722264,
-0.034941643,
0.028819505,
0.010045389,
0.0005426214,
-0.0042975284,
0.003226488,
0.013928536,
0.022015642,
-0.0098448815,
0.014249347,
0.017818367,
0.010733795,
-0.012578458,
-0.0065632546,
0.014449853,
0.002832158,
-0.013347067,
0.015158311,
0.032214753,
0.0006495584,
0.0227241,
-0.016200947,
0.023258785,
-0.020839335,
0.020719033,
0.0074187503,
-0.0025648156,
-0.025985677,
0.00062658364,
-0.014195879,
-0.021026475,
-0.012063824,
0.009704527,
-0.0090495385,
0.00086552085,
0.012277697,
0.01673563,
-0.014489955,
0.03181374,
0.0032498804,
-0.007057838,
-0.017657962,
-0.015987072,
0.0033033488,
-0.000097955904,
-0.0017694721,
-0.030851306,
0.022804303,
0.019729866,
0.02045169,
-0.020612095,
0.013594358,
0.016321251,
-0.032081082,
-0.0015664591,
0.0015764844,
-0.011856633,
0.0056709996,
-0.0005422037,
0.022416655,
0.010533288,
-0.021988908,
0.022884505,
-0.02619955,
-0.025464358,
-0.016722264,
-0.025918841,
-0.010720428,
-0.007498953,
0.0054003154,
-0.0052465936,
-0.019622928,
0.021668097,
0.0145968925,
0.028365023,
-0.0020869412,
0.015759831,
-0.000050492195,
-0.015666261,
-0.01530535,
0.0075925225,
0.0019783333,
-0.014436487,
0.0029624873,
0.017965406,
-0.03389901,
-0.007980169,
-0.030824572,
-0.011067973,
-0.017738165,
0.0038530715,
0.0050795046,
0.004407807,
-0.01027263,
-0.0046183392,
0.0058681644,
0.009069589,
-0.023633063,
0.0020802577,
-0.022363188,
-0.015773198,
0.01725695,
0.010065439,
-0.017123278,
0.0010718757,
-0.045367997,
-0.046998784,
-0.034246556,
0.01335375,
0.00867526,
0.022683999,
-0.007679409,
0.009791413,
0.04066277,
0.007091256,
0.007692776,
0.01057339,
0.018219382,
0.021975541,
-0.020946274,
-0.013293598,
-0.64974886,
-0.0503673,
0.007164775,
-0.019649662,
0.009256729,
0.01900804,
0.019355586,
0.021534426,
-0.02267063,
0.027148616,
0.005380265,
0.046758175,
0.01008549,
-0.021681465,
0.0020852704,
-0.020064043,
0.003802945,
-0.022189414,
-0.00009466634,
-0.029808672,
-0.025852004,
0.011101391,
-0.027857073,
0.004842238,
0.012651976,
0.026453525,
0.02758973,
-0.014463221,
-0.007986853,
0.003986743,
-0.0025481067,
0.04159847,
0.0028288162,
0.025009876,
0.048014686,
-0.017176745,
-0.015144944,
0.0053067454,
0.03181374,
0.025731701,
0.0026099298,
-0.006870698,
0.009443868,
0.0027135247,
-0.029487861,
0.017002974,
0.010767213,
0.0053568725,
-0.015358818,
0.0062190513,
0.005560721,
0.0026633982,
0.0014378006,
0.005056112,
0.0056041637,
-0.013901802,
0.01735052,
0.0070043695,
0.011402152,
0.0018713964,
0.007358598,
0.005527303,
-0.013875068,
-0.02424795,
-0.018633762,
0.019021409,
-0.014703829,
0.0061254813,
0.014062207,
-0.004574896,
0.015960338,
0.013066357,
0.01641482,
0.008381182,
0.031867206,
0.018954573,
0.0015355475,
0.01710991,
-0.013968637,
0.011482353,
-0.0047119088,
0.020411588,
0.0017160036,
0.018807534,
0.015572691,
0.0068840655,
-0.03667937,
0.031893943,
0.0040936796,
-0.023432557,
0.012010355,
0.032428626,
-0.0038363626,
-0.014690462,
-0.008768829,
0.025170282,
-0.0067771287,
-0.00026859553,
0.020719033,
-0.016962873,
-0.019823436,
-0.006509786,
0.010586757,
0.014663728,
0.0005129631,
0.008448018,
-0.031198852,
0.03566347,
0.029300721,
-0.017911937,
0.014249347,
-0.002513018,
0.0073986994,
-0.0049458332,
0.03403268,
-0.027696667,
0.009884983,
0.0012030406,
-0.015131577,
-0.030824572,
0.03440696,
-0.007525687,
0.020197714,
0.011462303,
0.009684476,
0.026600564,
-0.0066367737,
-0.017403986,
-0.0072783954,
-0.0197566,
0.01254504,
-0.0020652197,
0.014262714,
-0.009042854,
0.020986374,
-0.014276082,
0.016187578,
0.003665932,
-0.000711799,
-0.037080385,
-0.016120743,
-0.005858139,
0.015078109,
-0.0267075,
-0.013834966,
-0.013527523,
-0.012090557,
-0.0016241048,
0.015545958,
-0.002845525,
-0.005259961,
-0.01748419,
-0.0025197016,
0.0056242147,
-0.005386948,
-0.0012648635,
-0.005039403,
-0.014556791,
-0.0066167233,
0.008955969,
-0.0012698761,
0.015586059,
-0.0207324,
-0.011442252,
-0.006767103,
-0.04167867,
-0.0015121552,
-0.014222613,
-0.005931658,
-0.015786566,
-0.01859366,
-0.019729866,
0.0021571186,
0.024141014,
0.0023977268,
0.024314787,
0.018246114,
0.00014338322,
0.014717196,
-0.000651647,
0.000024828376,
-0.015880136,
-0.015158311,
0.020144247,
0.03371187,
0.0028087655,
0.0024294737,
0.0005058618,
-0.005968418,
0.014957804,
-0.00084129296,
0.018740699,
-0.022135947,
-0.0035322607,
-0.0090027535,
-0.0405291,
-0.0054203663,
-0.0042073,
0.0005973431,
0.022176048,
0.04919099,
-0.008187359,
0.03806955,
-0.017310416,
0.005637582,
-0.0077328775,
-0.0022189415,
-0.0032615766,
0.02828482,
-0.008167309,
-0.0014511676,
-0.014169144,
0.016521757,
-0.038657703,
-0.0041605155,
0.006132165,
-0.011027872,
-0.012932686,
-0.013387168,
-0.0031262345,
0.002437828,
0.006205684,
0.031011712,
0.010940986,
-0.009717895,
-0.024194483,
0.025731701,
0.0074454844,
-0.0054003154,
-0.003863097,
-0.002362638,
0.024889572,
0.005082846,
0.0121974945,
0.027723402,
-0.00041438063,
0.0058982405,
-0.01363446,
0.019703131,
0.02156116,
0.00212203,
0.018326318,
0.015104842,
0.008167309,
0.0068840655,
0.002711854,
0.014249347,
0.009216627,
-0.006710293,
0.009430502,
0.01571973,
0.005376923,
0.0015756489,
0.012210862,
-0.0030560573,
0.0052265427,
0.0015330412,
0.02841849,
0.02986214,
0.01175638,
0.0048556053,
0.0346743,
0.0021671439,
0.009443868,
-0.0045047184,
-0.028766036,
-0.0009231665,
0.0019064851,
-0.016200947,
0.0030360066,
-0.029621532,
-0.014262714,
0.0345139,
-0.012792331,
-0.00614219,
0.014770664,
0.03427329,
-0.0028756012,
0.018433254,
-0.001446155,
0.003256564,
-0.029514596,
-0.0014294462,
0.02916705,
0.0018563584,
0.004454592,
0.00034065262,
0.002165473,
-0.010045389,
0.03547633,
-0.010753846,
0.016254414,
0.015278615,
0.015773198,
0.008828981,
-0.017698063,
0.030450294,
-0.017845102,
0.0015447375,
-0.043817412,
-0.014730563,
-0.0059884684,
-0.010098857,
-0.013079724,
0.039165653,
0.0112083275,
-0.0011946862,
-0.030156218,
-0.0032398552,
-0.024154382,
0.019983841,
-0.01502464,
0.0055841133,
0.023018176,
0.0058046705,
0.004892365,
-0.030156218,
-0.007131357,
0.028151149,
-0.0073986994,
0.0073051294,
-0.022336453,
-0.0014102309,
-0.011168227,
0.028872974,
0.0032381841,
0.01254504,
0.020331385,
0.022363188,
0.009945136,
-0.010673643,
-0.016682163,
-0.0027820312,
0.010098857,
0.001316661,
0.0011621037,
0.016347984,
-0.009276779,
0.0054270495,
0.014917703,
0.008448018,
-0.0050795046,
-0.012083874,
-0.010733795,
-0.0036358559,
-0.024675699,
0.018807534,
0.020211082,
0.012344533,
-0.025464358,
0.017096544,
0.012698761,
-0.015131577,
-0.003121222,
-0.010813998,
-0.0098783,
0.00080912834,
-0.0071981926,
-0.014837501,
-0.018740699,
0.023993976,
-0.019515991,
0.015479122,
0.0152518805,
0.004317579,
0.004407807,
0.0030376774,
0.00052048214,
0.017056441,
-0.012498255,
0.0009816476,
0.021734932,
-0.025811903,
-0.0247559,
0.0073051294,
-0.0056509487,
-0.021226982,
-0.011595975,
-0.006402849,
-0.01363446,
0.007345231,
-0.011883367,
-0.0010702049,
-0.02619955,
0.0009231665,
0.004290845,
0.003438691,
0.0018580293,
-0.028017478,
-0.030878041,
-0.051490135,
-0.01715001,
-0.01354089,
-0.0034320073,
-0.016775733,
-0.0010560022,
-0.03408615,
0.008087106,
0.0035255773,
-0.0038196538,
0.009657742,
-0.00424406,
-0.008969336,
0.004972568,
-0.014757298,
0.013955271,
-0.0004824694,
-0.029648267,
-0.0035088684,
-0.0045013768,
-0.020251183,
-0.005948367,
0.0032532222,
0.0188209,
0.009356982,
-0.029327456,
0.007899966,
0.0024278027,
0.0075190035,
-0.01066696,
0.018018873,
0.030878041,
-0.0077195102,
-0.022510225,
-0.010312731,
-0.012418052,
-0.01126848,
-0.021347286,
-0.011736329,
0.0068205716,
-0.04205295,
-0.004180566,
0.01414241,
-0.002075245,
0.0153454505,
-0.0030410192,
-0.00073769776,
-0.028311554,
0.035075314,
0.02114678,
-0.00929683,
0.0041237557,
0.021801768,
0.014663728,
0.009169842,
0.0094238175,
0.009310197,
0.01600044,
-0.012765597,
0.01859366,
0.01706981,
-0.0247158,
-0.033925746,
-0.0040201605,
-0.025972309,
0.04419169,
-0.0046450733,
0.007138041,
-0.009798097,
-0.025985677,
-0.009437185,
0.0069843186,
0.00089559687,
-0.017497556,
0.016160846,
-0.00493915,
-0.0045648706,
-0.012538356,
0.006526495,
-0.019703131,
-0.021855237,
-0.0016224339,
-0.043657005,
-0.0060553043,
0.004962542,
0.015840035,
-0.00259155,
-0.008474752,
-0.010279314,
-0.0168292,
0.006319305,
-0.0089025,
0.047934484,
0.012384634,
0.054644775,
-0.0038597551,
0.024822736,
0.022710733,
0.01008549,
0.011642759,
-0.0015330412,
0.006466343,
-0.010219161,
0.01725695,
0.023205316,
0.0046952,
0.015425653,
0.005046087,
0.02452866,
0.014369651,
-0.005249935,
-0.049832612,
-0.0005869,
-0.040181555,
-0.014944437,
-0.012832433,
0.0013275219,
-0.00187808,
-0.048656307,
0.0020518524,
-0.010566706,
0.01799214,
0.009804781,
-0.008768829,
0.037080385,
-0.015479122,
-0.009417134,
0.03732099,
0.007846498,
0.009664426,
-0.008628475,
-0.0038798058,
0.001423598,
0.017684696,
0.010165692,
0.01660196,
-0.007138041,
0.008635158,
-0.032749437,
0.0022122578,
-0.0080135865,
-0.0006144697,
0.0024662332,
-0.019957107,
0.0015455729,
-0.019783333,
-0.005039403,
-0.018620394,
-0.017938672,
0.009624325,
0.0010543314,
0.017724797,
-0.032428626,
0.0075390544,
-0.0024010683,
-0.03542286,
0.012932686,
-0.022309719,
0.012845799,
0.0336584,
-0.0126653435,
-0.012364583,
0.02095964,
0.01354089,
-0.0053067454,
0.022042377,
0.032268222,
-0.02267063,
-0.012999522,
-0.009550805,
0.0010409643,
-0.018446622,
-0.027910542,
0.0070043695,
0.01735052,
0.0051864414,
-0.011201644,
-0.01706981,
-0.035529796,
0.025023244,
-0.008849031,
-0.0068573314,
0.013687928,
-0.024555394,
0.009684476,
0.019823436,
-0.009965186,
0.014743931,
-0.002225625,
-0.017310416,
0.008133891,
-0.020531893,
-0.014302815,
0.015920237,
-0.013594358,
0.02434152,
-0.012478204,
0.0060954057,
0.020518525,
-0.0033685137,
-0.0070979395,
-0.003089475,
-0.0063594063,
0.03376534,
-0.0033267413,
-0.011007821,
0.044672906,
0.025170282,
-0.008708677,
-0.030984977,
-0.016521757,
-0.00820741,
-0.0197566,
-0.00029971584,
0.021601262,
0.013006205,
-0.016094008,
-0.007960118,
-0.027429326,
0.0076259403,
-0.017323785,
-0.01924865,
0.0074922694,
-0.05360214,
-0.019141711,
-0.011101391,
-0.011642759,
0.011402152,
-0.0055674044,
0.015786566,
-0.0039098817,
-0.01660196,
-0.0059149493,
0.014195879,
0.01154919,
0.016160846,
-0.018112443,
0.004621681,
-0.034246556,
-0.009129741,
0.005894899,
0.0069308504,
-0.03042356,
-0.014396385,
-0.0072048763,
0.016147478,
0.01237795,
0.009497337,
0.025798537,
0.004528111,
0.0031613233,
0.0066367737,
-0.01539892,
0.021574527,
-0.023178581,
0.011542506,
0.01078058,
-0.018018873,
0.0137012955,
-0.0016750669,
0.007057838,
-0.006767103,
-0.017738165,
0.012070507,
0.0049792514,
0.04272131,
-0.019596195,
-0.012558407,
-0.002890639,
-0.00475201,
-0.01451669,
0.009737945,
0.004574896,
-0.034059417,
-0.016802467,
-0.018834269,
0.0031563106,
-0.0013099775,
-0.014316183,
-0.005664316,
-0.0009106349,
-0.010519922,
-0.011148176,
0.013687928,
-0.014984539,
0.036224887,
0.0075657885,
-0.030209685,
-0.02146759,
-0.004832213,
-0.027375856,
-0.0058882153,
-0.018219382,
-0.0022139288,
-0.016147478,
-0.0043042116,
0.016361352,
0.037481397,
-0.005754544,
0.0033668426,
-0.005724468,
-0.011408835,
0.015786566,
-0.038737904,
0.022069111,
0.013681245,
-0.065391935,
-0.01562616,
0.017698063,
0.0009281792,
0.011636076,
0.025210382,
0.002634993,
-0.00941045,
-0.01562616,
0.018219382,
-0.023151847,
0.007940068,
0.002651702,
-0.046998784,
-0.005801329,
0.0054838597,
0.008307664,
-0.0017026366,
0.0073986994,
-0.01068701,
0.013601042,
0.003863097,
0.0012623571,
-0.003121222,
0.00929683,
-0.014129043,
0.0038430463,
-0.0036391977,
-0.005637582,
0.0048823394,
0.027990744,
-0.005757886,
0.0010710403,
0.009116374,
0.00011884203,
-0.014088942,
-0.0020485108,
0.006336014,
-0.019074876,
0.0060553043,
-0.006583305,
0.002075245,
0.0006842293,
0.021708198,
-0.014062207,
0.014743931,
0.012778964,
-0.005453784,
-0.03796261,
-0.0063827983,
-0.0016107376,
-0.0019716497,
0.012732179,
-0.01706981,
0.011148176,
-0.027161982,
-0.017644595,
-0.010807314,
-0.023031544,
0.0105065545,
0.015706362,
-0.019502625,
-0.016722264,
0.023820203,
0.18371765,
0.006800521,
-0.0010718757,
0.016535124,
-0.0033685137,
-0.016374718,
0.005029378,
0.005497227,
-0.02509008,
0.032990046,
0.014743931,
0.010947669,
-0.02411428,
-0.0059082657,
0.018901104,
-0.0021019792,
-0.01228438,
-0.023298886,
-0.004447908,
0.0042173257,
-0.007138041,
0.008935918,
0.014155777,
-0.00024415876,
0.015291982,
-0.00867526,
0.0047586937,
0.013066357,
0.016160846,
-0.0015764844,
-0.0121974945,
-0.0167891,
-0.003406944,
-0.010466453,
0.023833571,
-0.01562616,
0.004578238,
0.009731261,
-0.0036692738,
-0.0042774775,
-0.029060112,
-0.00012197495,
-0.0033685137,
0.0011545848,
0.0069776354,
-0.005654291,
0.00073728006,
-0.013153244,
-0.029514596,
-0.004862289,
-0.01502464,
-0.015973706,
0.009082956,
0.0030309937,
-0.010011971,
-0.0027436009,
0.040956847,
-0.0011729646,
-0.013661194,
0.022122579,
0.015826667,
0.015773198,
-0.007392016,
0.0018079026,
-0.015492489,
0.0207324,
-0.025557928,
-0.016214313,
-0.023967242,
0.007191509,
0.013848334,
-0.015639527,
-0.025557928,
0.03432676,
-0.015479122,
-0.033230655,
0.01451669,
0.038363628,
-0.0082007265,
0.013641143,
0.01156924,
-0.0227642,
-0.017083175,
0.0077930293,
-0.03111865,
-0.032909844,
0.02550446,
0.008909184,
0.0047185924,
0.032188017,
0.014356284,
0.009477287,
-0.025009876,
-0.03389901,
0.020705665,
-0.017002974,
0.015465755,
0.0045715543,
-0.016802467,
0.009744628,
-0.02559803,
0.08164635,
-0.023552861,
0.008240828,
-0.004741985,
-0.010346149,
-0.036064483,
0.019930372,
-0.010259262,
0.014476588,
0.016575225,
-0.027562996,
-0.00008255239,
-0.02341919,
-0.0024127646,
0.036518965,
0.012765597,
-0.018673863,
0.039112184,
-0.0306107,
-0.0074388008,
-0.017470822,
0.0016976239,
0.021226982,
-0.003181374,
0.002105321,
0.014369651,
-0.0074922694,
-0.025758436,
-0.04507392,
-0.00478877,
0.014222613,
0.02253696,
0.010566706,
-0.01414241,
-0.015652895,
-0.014890969,
-0.009818148,
-0.021721566,
0.036251623,
-0.013995372,
-0.01701634,
0.02809768,
0.013955271,
0.014155777,
-0.028258085,
0.020104144,
-0.0066167233,
-0.027910542,
-0.0067270016,
0.004197275,
-0.007138041,
0.009129741,
-0.011729646,
0.021120045,
-0.022456758,
-0.02680107,
-0.02291124,
-0.011128125,
0.018446622,
-0.03812302,
0.010299364,
0.040368695,
0.011462303,
-0.0063995076,
0.016027173,
-0.16938812,
-0.00023162708,
0.021347286,
-0.017551025,
0.032909844,
-0.0049324664,
0.014088942,
0.010392934,
-0.038096283,
-0.023526127,
0.027669933,
0.00948397,
-0.025958942,
-0.044432297,
0.0064730267,
0.0113821,
-0.0037093752,
0.0047018835,
0.02341919,
0.005510594,
0.011021188,
-0.0022206123,
0.01335375,
-0.003288311,
0.00614219,
0.022095844,
-0.00057311513,
0.030263154,
-0.013106459,
0.0061555575,
-0.0001890194,
0.0078732325,
0.035636734,
0.021293817,
-0.022657264,
0.0041772244,
-0.0095641725,
0.026319854,
0.0036492231,
0.04191928,
0.008615107,
0.023058277,
0.012077191,
0.010078806,
-0.018419888,
0.022216149,
0.029648267,
-0.00967111,
0.023445923,
-0.02494304,
0.019716498,
0.0074454844,
0.0011679519,
0.017831735,
-0.005831405,
0.004347655,
0.003665932,
0.0065031024,
-0.003330083,
0.015318717,
-0.007692776,
-0.028311554,
0.030022545,
-0.013286915,
-0.020932905,
-0.009771363,
-0.007178142,
-0.012966104,
-0.0167891,
-0.00095324253,
-0.018446622,
0.0005885709,
-0.0069843186,
-0.003876464,
0.02114678,
0.035877343,
-0.001121167,
0.019689763,
-0.002165473,
0.0005188112,
-0.0010234199,
0.002270739,
-0.024328154,
-0.019970473,
0.0071246736,
0.0007677738,
-0.0038096285,
0.0027452717,
-0.0029959052,
-0.015545958,
0.032428626,
-0.029568063,
-0.0025247142,
0.022002276,
-0.000012851491,
0.004651757,
0.0023125112,
-0.0018379786,
0.013380485,
-0.022470124,
0.022323087,
-0.008782196,
0.00019820928,
0.006148874,
0.015265248,
-0.0022189415,
-0.0014804082,
-0.005998494,
0.030316623,
-0.01910161,
-0.0058547975,
-0.004133781,
0.026627298,
0.018312952,
0.011702911,
0.027456058,
0.022029009,
-0.0025380815,
0.021079944,
-0.026506994,
0.048282027,
0.004377731,
-0.031733535,
-0.011849949,
-0.0158133,
-0.0028572213,
-0.12169424,
-0.025491092,
-0.0000808815,
-0.006890749,
0.024983142,
0.008240828,
-0.010105541,
-0.002060207,
-0.03042356,
0.037855677,
-0.025116814,
-0.02323205,
-0.02689464,
-0.016027173,
0.057906352,
0.03833689,
-0.0008947614,
-0.03491491,
-0.008274246,
0.035716936,
0.011221695,
0.013413902,
0.012237596,
-0.025424257,
0.014316183,
-0.03194741,
-0.02341919,
0.020852704,
0.016775733,
0.027723402,
0.015465755,
-0.0004452921,
-0.013093092,
-0.016347984,
-0.0072984463,
-0.027068412,
-0.027696667,
-0.008254195,
0.027776869,
-0.0345941,
0.008260879,
0.0027085121,
0.016802467,
0.0068272552,
0.016120743,
0.024100913,
-0.018326318,
-0.016748998,
-0.00038806413,
-0.01692277,
-0.015412286,
-0.022683999,
0.013714663,
0.0070979395,
0.01530535,
0.00009132456,
-0.0054738345,
0.026226284,
0.0072048763,
-0.003863097,
0.00046952,
0.014396385,
-0.0345941,
0.003876464,
0.019769967,
-0.033257388,
0.004955859,
-0.02685454,
-0.018927839,
0.0009515717,
-0.01729705,
0.046357162,
-0.007692776,
0.0016817504,
-0.025798537,
-0.016160846,
-0.018901104,
-0.008441335,
0.02058536,
-0.011241746,
0.010105541,
-0.016815834,
-0.0032348423,
0.0012088887,
0.0012840787,
0.02509008,
0.0005538999,
0.005544012,
0.016588593,
-0.01729705,
-0.019021409,
0.0227241,
-0.00021617135,
-0.015104842,
0.015291982,
0.017818367,
-0.02114678,
-0.035850607,
0.014717196,
0.0017059783,
-0.020064043,
0.023526127,
-0.06560581,
0.0051429984,
0.014035474,
-0.0047386433,
-0.017952038,
-0.006797179,
0.001741067,
0.022456758,
0.001771143,
-0.02860563,
-0.032802906,
0.005998494,
-0.032348424,
-0.0044311993,
-0.00082416635,
0.012063824,
0.021079944,
0.020705665,
0.029915608,
0.008962652,
-0.027402591,
-0.010045389,
-0.012484888,
0.017778266,
0.013193345,
-0.00028843732,
-0.0057344935,
0.013848334,
-0.007358598,
0.0027920566,
0.027536262,
-0.024542028,
-0.02026455,
-0.009851566,
-0.013687928,
-0.03125232,
0.012591825,
0.00087471073,
0.029434392,
-0.0029775253,
-0.03486144,
-0.026587196,
0.021347286,
-0.01915508,
-0.011950203,
0.013794865,
-0.0137012955,
0.024822736,
-0.014944437,
-0.019876903,
0.036919978,
0.018286217,
0.013026256,
-0.035770405,
-0.02847196,
0.010907568,
-0.005858139,
0.004240718,
-0.00061363424,
-0.008367815,
0.0045916047,
-0.014677095,
-0.007846498,
0.00087638164,
0.011595975,
-0.0005129631,
-0.00014829145,
-0.008915868,
0.014837501,
-0.0074922694,
-0.01891447,
0.0061254813,
-0.014556791,
0.026052512,
0.009310197,
-0.005654291,
-0.005544012,
0.040609304,
-0.017831735,
0.012271014,
0.010205794,
-0.00076359656,
-0.015586059,
0.047881015,
0.006830597,
0.0024194482,
-0.011321949,
0.026587196,
-0.0021487642,
0.011081341,
-0.039967682,
0.0056409235,
-0.02694811,
0.0032682603,
-0.002030131,
0.016962873,
-0.0048556053,
-0.012825749,
0.001893118,
0.026493626,
0.0049157576,
0.0079200175,
-0.013754764,
-0.008688626,
-0.031974144,
-0.004190591,
-0.018660495,
-0.014276082,
-0.0024662332,
0.0060553043,
0.021120045,
-0.0022306377,
0.011088024,
0.00015434844,
-0.004878998,
-0.023713266,
-0.005694392,
-0.024274684,
-0.009791413,
0.034807973,
-0.0038363626,
0.008361132,
0.014062207,
-0.0005781278,
0.026680766,
0.018513458,
0.026279753,
-0.0039566667,
0.015078109,
-0.0050661373,
0.011970254,
-0.0054571256,
-0.027028311,
-0.016120743,
0.00950402,
-0.019395687,
0.009925084,
0.03713385,
-0.0072516613,
0.090735994,
-0.010212477,
-0.018206013,
0.0026633982,
-0.0022473466,
0.0057478603,
-0.0022456758,
0.0074120667,
-0.01571973,
-0.0109276185,
0.015746465,
-0.0096109575,
0.01799214,
-0.010212477,
-0.01049987,
-0.01891447,
0.0072717117,
0.032909844,
0.00781308,
0.010399617,
0.009584223,
-0.013066357,
-0.0076125734,
0.0017828393,
-0.012458153,
0.0029424366,
0.017925303,
-0.020010574,
-0.010078806,
-0.025063345,
-0.025852004,
0.019181814,
-0.028685834,
-0.030102748,
0.025905473,
0.024689065,
-0.016428187,
-0.0006240773,
0.013821599,
-0.033551466,
-0.01859366,
0.03213455,
-0.012050456,
-0.01342727,
-0.036091216,
-0.03515552,
-0.01872733,
-0.0047653774,
-0.00133337
] |
Circadian timing is generated through a unique series of autoregulatory interactions termed the molecular clock. Behavioral rhythms subject to the molecular clock are well characterized. We demonstrate a role for Bmal1 and Clock in the regulation of glucose homeostasis. Inactivation of the known clock components Bmal1 (Mop3) and Clock suppress the diurnal variation in glucose and triglycerides. Gluconeogenesis is abolished by deletion of Bmal1 and is depressed in Clock mutants, but the counterregulatory response of corticosterone and glucagon to insulin-induced hypoglycaemia is retained. Furthermore, a high-fat | [
-0.04187895,
-0.0026585632,
0.02141328,
-0.037877943,
-0.025664348,
0.0061397017,
-0.015885573,
-0.014858999,
-0.024203453,
-0.0023821779,
0.020952636,
0.004534035,
0.0009903806,
0.0116081815,
-0.024177132,
-0.004580099,
0.023453265,
0.0023114365,
0.0019972126,
0.01257553,
-0.021136893,
0.023137396,
-0.0069688577,
-0.007672982,
-0.0021140184,
0.0031257858,
-0.010186772,
-0.02950742,
-0.013338881,
-0.019754967,
0.016451504,
-0.010469737,
-0.014911644,
0.018096656,
0.008331042,
-0.01934697,
0.0018014398,
-0.021505408,
-0.0018590201,
-0.015609188,
0.015451253,
0.014121972,
-0.0016632471,
0.0040733926,
-0.024006035,
0.013911393,
0.04011535,
-0.0056362855,
-0.01017361,
0.016004024,
-0.0039812643,
0.019754967,
-0.00830472,
-0.020307738,
-0.003094528,
0.0039088777,
0.023400621,
0.020715736,
-0.0051098373,
-0.02045251,
-0.001880407,
-0.014714226,
-0.020926313,
0.0069885994,
0.033929583,
-0.013398105,
-0.0064127967,
0.0010092999,
0.0051953853,
-0.007751949,
0.03192908,
0.009430002,
-0.0049387417,
0.012608433,
0.019307487,
-0.031428955,
-0.029375806,
-0.0035831379,
0.0069688577,
0.0010191707,
0.0069951797,
0.0004084086,
-0.018530976,
0.039352,
-0.0021123732,
0.0049782256,
0.002581241,
-0.0061298306,
-0.0020366963,
0.016280409,
0.005702092,
0.0063272486,
0.035772152,
0.011562117,
-0.024532484,
0.0071531143,
-0.01125283,
0.029717999,
-0.0018573749,
-0.0024282422,
0.0071991784,
0.012957205,
-0.017293822,
-0.022439852,
-0.014490485,
-0.025835443,
0.014635259,
-0.030981474,
0.011160701,
-0.00328043,
-0.01704376,
0.038851876,
-0.015543382,
-0.04943348,
-0.008706137,
0.0021567922,
0.002525306,
-0.00470184,
0.014240422,
-0.013845586,
0.028059687,
0.020794703,
0.025769638,
-0.014043004,
0.008021754,
0.0082125915,
0.010588189,
-0.018754715,
-0.013398105,
-0.014161455,
-0.026256602,
0.011331797,
-0.014832677,
0.0058435746,
-0.021702826,
0.0057547363,
-0.017017437,
0.013977199,
-0.016885825,
-0.0212027,
-0.011305475,
0.014069327,
-0.03200805,
0.018333558,
0.011391022,
0.03595641,
0.022821527,
0.03342946,
-0.026190795,
-0.0042477786,
0.018465169,
-0.0062384107,
0.0057514464,
-0.0007119389,
0.027559562,
0.026506664,
-0.010844832,
0.033745326,
-0.010403932,
-0.021229021,
0.01889949,
-0.01639886,
0.03793059,
0.016596278,
0.023795458,
0.0015217642,
0.012404434,
-0.018109817,
0.010884316,
0.000923752,
0.0052644815,
0.011680569,
-0.022874173,
0.033534747,
-0.02307159,
0.041089278,
0.018596781,
0.0064358287,
-0.003124141,
-0.009930128,
-0.047617234,
0.0012281048,
0.009607679,
0.017859753,
-0.0035568154,
-0.0059554446,
0.020136641,
-0.030744573,
0.026743567,
-0.023558555,
-0.008350784,
0.0019856966,
-0.010989605,
-0.02229508,
-0.6346859,
-0.007837497,
0.001131041,
-0.01179902,
-0.0089825215,
0.026256602,
0.01782027,
-0.0036588148,
0.012700561,
0.023927068,
-0.000923752,
0.014635259,
0.014832677,
-0.028902004,
-0.016425183,
-0.03527203,
-0.0026273055,
-0.026164474,
0.018741554,
-0.015122224,
-0.011068572,
-0.0020185998,
0.004942032,
0.012062243,
0.001814601,
0.0129703665,
0.03848336,
-0.01770182,
-0.0031570438,
0.041484114,
-0.007508467,
0.013674491,
-0.0047808075,
-0.007666401,
0.04645905,
-0.010956703,
-0.03292933,
0.021176377,
0.0030961733,
0.034613967,
-0.020689413,
-0.001803085,
0.030481348,
0.004221456,
-0.020689413,
0.007521628,
0.003356107,
-0.0077453684,
0.0036259117,
-0.019847095,
0.024216615,
0.0044287452,
-0.023848101,
-0.010338126,
0.011127798,
0.0066529885,
0.009857742,
-0.012753206,
0.010785607,
0.0050144186,
0.0067582782,
0.03071825,
0.0019050842,
-0.0021765342,
-0.0051953853,
0.0033001718,
-0.019149551,
0.011680569,
0.012114888,
-0.014372035,
0.017399112,
0.010403932,
-0.010272319,
0.02132115,
0.01749124,
0.014793193,
0.01596454,
-0.002941529,
0.0023821779,
0.021913406,
0.0078111747,
0.0069359546,
-0.016372537,
-0.015424931,
0.029744321,
-0.009745872,
0.013977199,
0.009199682,
-0.014661581,
0.005639576,
0.02165018,
-0.007311049,
0.010522382,
-0.024321904,
-0.01847833,
0.03442971,
-0.01782027,
0.007462403,
0.028796714,
-0.033324167,
-0.009476067,
-0.0043102945,
0.00092868746,
0.005060483,
0.020649929,
-0.005399384,
-0.02034722,
0.000064469335,
0.03674608,
-0.027664851,
-0.00044254548,
0.009357616,
-0.001010945,
0.008883812,
0.006363442,
-0.026940985,
0.031244699,
-0.0031011086,
0.015872411,
-0.022545142,
-0.004734743,
-0.010371028,
0.01234521,
-0.013194107,
0.008028334,
0.0035173318,
0.027138403,
-0.015911896,
-0.0046491954,
-0.02130799,
0.0063502807,
-0.007896722,
0.015819767,
-0.021505408,
0.04056283,
0.0011269281,
0.030586638,
-0.007028083,
0.0074492414,
-0.032060694,
-0.015030095,
-0.0045965505,
-0.01278611,
-0.0006843826,
0.00009146008,
-0.005192095,
-0.00775853,
0.014240422,
0.02950742,
0.01749124,
0.022834688,
-0.011061992,
-0.013444169,
0.0064095063,
0.006100218,
-0.012068824,
-0.043984745,
-0.008396848,
-0.00809414,
0.012371532,
0.010469737,
0.013036173,
-0.009693227,
0.0035897184,
-0.009199682,
0.0045735184,
0.008469235,
-0.01553022,
-0.0070544053,
-0.023690168,
0.0033001718,
-0.016385699,
-0.010575027,
0.0029793675,
0.0021502117,
0.018491492,
-0.015016934,
0.00053385133,
-0.014016682,
-0.020886831,
0.0031932371,
0.0018968586,
-0.013911393,
-0.013194107,
0.045748346,
0.007837497,
0.016543634,
-0.0018178913,
0.00010086829,
0.033587392,
-0.00082586554,
0.032639787,
-0.019794451,
0.0030863024,
0.0068569873,
-0.042800236,
0.004655776,
-0.009811678,
0.0079164645,
0.018201945,
0.02141328,
-0.033403136,
0.014898483,
-0.021347472,
0.019610194,
-0.034377065,
0.011706891,
-0.01223992,
0.0046195826,
-0.0018063752,
0.00043843262,
0.028507167,
0.0069491155,
-0.007258404,
0.018280912,
-0.000006953331,
-0.019202197,
-0.015911896,
-0.004613002,
-0.0021354053,
0.013674491,
0.017333306,
0.026822533,
-0.00940368,
0.0014576033,
0.028507167,
0.0011935567,
0.009133875,
-0.0040371995,
-0.00015885984,
-0.01060135,
0.018623104,
-0.0045274543,
0.0040832637,
0.003586428,
0.0024956933,
-0.017241178,
-0.0015266996,
0.03398223,
0.012266242,
-0.00040758605,
0.008666653,
0.025019448,
-0.0040799733,
-0.008396848,
-0.0040733926,
0.014121972,
0.008107302,
0.008442912,
0.003991135,
-0.019623356,
-0.007028083,
-0.021360634,
-0.008936457,
0.012095147,
0.0018178913,
0.007120211,
-0.013398105,
0.024335066,
0.01826775,
-0.0012799271,
0.025716992,
-0.016780535,
-0.022768883,
-0.00024697822,
-0.0011162346,
0.027270015,
-0.007304468,
-0.030139158,
0.008975941,
-0.024756225,
0.021584375,
-0.0030073351,
-0.043879453,
0.047090787,
-0.003685137,
0.010555286,
0.00024821208,
0.029349485,
0.022703078,
-0.0049913866,
-0.027191047,
0.019597033,
0.0129966885,
-0.013088818,
-0.0039977157,
-0.029033616,
-0.002763853,
0.017557045,
0.00020050272,
-0.003695008,
0.008206011,
0.010331545,
-0.011720052,
-0.016096152,
-0.0010808639,
0.022703078,
-0.0149774505,
-0.009541873,
-0.0075479504,
0.0050440314,
0.039246712,
-0.016806858,
-0.018188784,
0.013358622,
0.014740548,
0.01070664,
-0.0025318866,
0.007205759,
-0.018359879,
0.012944045,
-0.0019988578,
0.0046656467,
-0.025953894,
0.0113120545,
0.026006538,
0.0066398275,
0.009535292,
0.0012667659,
0.0070346636,
-0.021873921,
-0.008916716,
-0.01334546,
0.003081367,
0.028296588,
0.020847347,
-0.0076993043,
0.012062243,
-0.008548202,
0.011838503,
-0.03258714,
-0.029428452,
0.02458513,
-0.017004276,
0.003737782,
-0.010910638,
-0.02240037,
0.010338126,
0.002383823,
0.010213094,
-0.015490737,
-0.012364951,
0.019557549,
0.02832291,
0.014108811,
-0.026717244,
0.011595021,
0.048512198,
0.017767625,
-0.004425455,
-0.016148798,
0.013088818,
-0.007771691,
-0.034140162,
0.012167533,
0.0014913289,
-0.0061989273,
0.023545394,
0.0042773914,
-0.016122475,
0.020018192,
0.015556543,
0.0067911814,
-0.0011631214,
0.025453769,
0.012608433,
0.0018721813,
0.00010292473,
-0.0015612479,
-0.02908626,
-0.005389513,
0.024493001,
-0.013582363,
-0.0034252033,
0.022900496,
-0.014951128,
0.0015217642,
-0.01792556,
0.022966301,
0.0020301158,
-0.00073949515,
-0.006922793,
0.0063206684,
0.0079164645,
-0.021386957,
-0.009634001,
0.019636516,
0.005991638,
0.001103896,
0.017622853,
0.0035831379,
-0.011338377,
-0.022663593,
-0.0069820187,
0.008896974,
-0.027664851,
-0.011397603,
0.0009813323,
0.015938219,
0.030691927,
0.040957667,
-0.018280912,
0.013635008,
0.02404552,
-0.022768883,
-0.022584626,
-0.004086554,
-0.018570459,
0.0030435284,
0.005376352,
0.049880963,
-0.022374047,
-0.0052282885,
0.0020037934,
-0.002592757,
0.010871154,
0.036851373,
-0.0020087287,
-0.015438092,
-0.0062811845,
0.027164726,
0.026651438,
0.014687903,
-0.014029844,
0.004132618,
-0.014227262,
-0.018399363,
-0.009028586,
-0.004109586,
-0.007554531,
0.005336868,
0.005517835,
-0.0039417804,
0.013424428,
-0.0014247004,
0.006330539,
-0.007060986,
0.0080151735,
0.010528963,
0.0029678515,
-0.016530473,
0.019281164,
-0.0076269177,
-0.009548454,
-0.009976192,
-0.02634873,
0.014200939,
-0.0049255807,
-0.025545897,
0.024571968,
-0.010028837,
-0.010561866,
-0.012753206,
0.006353571,
-0.0023262429,
0.026309246,
-0.007172856,
-0.03103412,
-0.014661581,
-0.008008593,
-0.015925057,
0.011114636,
-0.018004527,
0.010265739,
-0.026111828,
0.012489983,
0.01901794,
-0.022018693,
0.019768128,
-0.037483107,
0.0018573749,
-0.007890142,
0.004853194,
0.020057674,
-0.013174365,
-0.004613002,
-0.035587896,
-0.014503647,
-0.007929625,
-0.03398223,
-0.0062449914,
-0.023045268,
0.047801495,
0.037667368,
0.023795458,
-0.005609963,
0.00874562,
0.012391274,
0.029428452,
0.0037739752,
-0.013542878,
0.003882555,
-0.031665858,
0.006218669,
-0.015424931,
-0.0061232504,
0.029823288,
0.0011376216,
-0.0016739407,
0.024111325,
0.0056033824,
-0.012634756,
-0.026506664,
-0.012562369,
-0.017714981,
0.01508274,
-0.014714226,
-0.020018192,
-0.029323163,
-0.03674608,
0.047564592,
0.019794451,
0.015280158,
-0.03845704,
0.011752956,
-0.041510437,
0.049328193,
-0.01946542,
0.0065937634,
-0.016201442,
-0.028296588,
0.0008949619,
0.0010084773,
0.016359376,
-0.0010175256,
-0.008265236,
-0.003586428,
-0.04493235,
-0.010272319,
-0.0020465672,
-0.0187942,
0.005366481,
-0.013937715,
-0.0076334984,
-0.013937715,
-0.020531477,
-0.045511443,
-0.041010313,
0.0011351538,
0.02633557,
-0.028717747,
0.029217873,
0.004613002,
-0.0008538331,
0.033824295,
-0.014253584,
0.033271525,
-0.0003051754,
0.045432474,
-0.0012799271,
0.008673233,
0.011114636,
-0.018083494,
0.012792691,
-0.008021754,
0.023979714,
0.013312558,
-0.019294325,
-0.0058633164,
0.016148798,
0.03342946,
-0.015043256,
-0.02141328,
0.022110824,
0.010298642,
-0.015385447,
-0.019215358,
-0.015872411,
-0.017228017,
-0.006689182,
-0.021768631,
0.012318887,
-0.006172605,
-0.018122979,
-0.025730154,
0.02351907,
-0.0023788877,
0.002337759,
0.009199682,
-0.02370333,
0.012654497,
-0.0027819495,
-0.019294325,
0.0037114595,
0.005017709,
0.023742812,
0.0025285962,
0.0064489897,
-0.0062976363,
0.00929181,
0.005731704,
-0.012285984,
-0.029165229,
0.03750943,
0.0073373714,
-0.0028921745,
-0.000068736445,
0.006712214,
0.012141211,
0.0133915255,
0.0016031992,
-0.011772697,
-0.019110069,
0.007936206,
0.017122727,
0.023690168,
-0.028902004,
-0.0065773115,
-0.024453517,
-0.021084249,
-0.03245553,
-0.019004779,
0.011404184,
-0.04832794,
0.026032861,
-0.025085256,
0.018122979,
0.023018945,
0.011423925,
-0.007705885,
-0.007923045,
0.009285229,
-0.027980719,
0.048170008,
0.0034416548,
0.012726884,
-0.007014922,
0.0016961502,
-0.008607428,
-0.04090502,
0.03258714,
-0.0044748094,
-0.037272528,
0.00059431064,
0.004889387,
0.015069579,
0.002318017,
-0.005521125,
0.013648168,
-0.00094267126,
0.019794451,
-0.0029629162,
-0.00097639684,
0.0014691195,
-0.041010313,
-0.0013983779,
0.012121469,
-0.0063140877,
-0.0076861433,
0.009127295,
-0.009285229,
-0.01541177,
0.0061528627,
0.007409758,
-0.027348982,
0.022979463,
0.0070346636,
0.003968103,
-0.027270015,
-0.011904309,
-0.028164977,
0.02570383,
-0.025861766,
-0.0021913406,
-0.022360886,
-0.027796462,
-0.0047051306,
0.032508172,
-0.015372287,
0.0028823037,
0.019162713,
-0.04951245,
-0.033850618,
-0.021939727,
-0.013924554,
0.035140414,
0.00874562,
-0.01093038,
-0.014845838,
-0.009443164,
-0.014595775,
-0.03803588,
0.017017437,
0.005626415,
0.0017405692,
-0.0042379075,
0.015556543,
0.012957205,
-0.008752201,
0.023426943,
-0.00015988806,
-0.016161958,
0.011226507,
-0.009541873,
0.03390326,
0.0047413236,
-0.0027622078,
0.0076005952,
0.005540867,
-0.027164726,
-0.0130690755,
0.025190545,
-0.008673233,
0.010660575,
-0.010844832,
0.010364448,
0.017149048,
0.013779781,
0.010101224,
-0.003912168,
-0.0075808535,
0.014345712,
-0.007824336,
-0.014964289,
-0.009831419,
0.007955948,
-0.0004886097,
0.0067846007,
-0.01999187,
-0.013740297,
0.017714981,
-0.012700561,
0.010785607,
0.021255344,
0.041826308,
0.0017849883,
0.010305223,
-0.010634253,
-0.0061528627,
0.00069630996,
-0.0052184174,
0.0024595,
-0.008975941,
-0.00037817896,
-0.004711711,
0.006731956,
0.03071825,
-0.029270519,
0.016517311,
-0.013246751,
0.009989354,
-0.025756476,
0.021715987,
-0.011068572,
-0.0091799395,
-0.014056166,
-0.00043719873,
-0.00907465,
0.003596299,
0.009884064,
-0.01924168,
-0.006817504,
-0.0005766252,
0.017122727,
-0.011022508,
0.013898231,
-0.0029316582,
-0.020834185,
-0.0054618996,
-0.0022916947,
0.17330673,
-0.02165018,
-0.010239417,
0.016359376,
-0.0025549186,
0.005889639,
0.0031619791,
0.011535795,
-0.0067977617,
0.024571968,
-0.0050341603,
0.0076927235,
-0.025861766,
0.004142489,
-0.0065082153,
-0.004636034,
-0.014016682,
-0.0030451736,
-0.007988851,
-0.019373292,
0.022887334,
-0.016754212,
-0.0040832637,
-0.008041495,
0.04098399,
0.0023311782,
-0.0021354053,
0.005290804,
0.01181218,
0.02919155,
-0.020899992,
0.019768128,
-0.017030599,
0.004274101,
-0.0046195826,
0.010502641,
-0.027901752,
-0.01596454,
-0.0066003436,
0.0071399533,
-0.021465924,
-0.0023476298,
0.0025269513,
-0.017662335,
0.018741554,
0.016161958,
0.0003750943,
-0.013806103,
0.00018076091,
-0.012114888,
-0.04032593,
0.025414284,
0.028559813,
0.042931847,
0.0029349485,
-0.014740548,
0.015253835,
0.015438092,
0.011660826,
0.033271525,
-0.014740548,
0.002393694,
-0.01595138,
0.024979966,
-0.020202449,
-0.0005412545,
-0.037404142,
0.007304468,
0.024729902,
-0.02043935,
0.008271817,
-0.008146785,
-0.014780032,
0.0025269513,
0.020505156,
-0.007508467,
0.027796462,
0.03869394,
0.0056527373,
0.024124486,
-0.020755218,
0.0090549085,
-0.020584123,
-0.020294577,
-0.0025516285,
-0.027980719,
0.031402633,
-0.008284978,
-0.0203209,
-0.029586386,
0.003727911,
-0.0018886328,
0.0031438826,
0.008350784,
-0.00161307,
-0.041905273,
0.0024019198,
-0.0060771857,
0.001049606,
-0.030981474,
-0.018530976,
0.04943348,
0.02261095,
0.023584878,
-0.0060607344,
-0.02887568,
-0.026401374,
-0.013134882,
0.009745872,
-0.0052513205,
0.012930883,
-0.036009055,
0.0102789,
-0.009831419,
-0.005126289,
0.028559813,
0.02196605,
-0.013977199,
0.0037312014,
-0.02045251,
-0.0011178798,
-0.0032080435,
-0.0029316582,
0.025111577,
-0.013503395,
-0.0031981727,
-0.021400118,
-0.01312172,
0.008548202,
-0.026598793,
0.0118056,
-0.015240674,
0.0027408206,
0.0013037818,
0.01978129,
-0.0046656467,
0.012397855,
-0.018122979,
0.0061232504,
0.020018192,
-0.022716237,
0.012700561,
-0.009653743,
0.010838252,
0.018860005,
-0.036798727,
0.018873166,
0.0040832637,
-0.030349737,
0.007554531,
-0.00097146136,
-0.017293822,
-0.005998219,
-0.018609943,
0.0143325515,
-0.008127043,
0.0028329492,
-0.06480577,
0.0010191707,
-0.004787388,
-0.019268002,
0.011680569,
-0.0028905293,
0.0064424095,
0.02087367,
0.0059784767,
-0.1645677,
0.0072847265,
0.023321653,
-0.029639032,
0.007192598,
0.0072978875,
-0.009193101,
-0.008324461,
-0.01693847,
0.0071531143,
0.016319893,
0.0037180402,
-0.020886831,
-0.012035921,
0.0024233067,
-0.0035765572,
-0.032534495,
0.04590628,
0.007455822,
0.0087587815,
0.011818761,
-0.02546693,
0.020781541,
-0.040378574,
-0.0057876394,
0.018596781,
0.019926064,
0.013213849,
-0.00092621974,
-0.027612206,
-0.03485087,
0.0001637953,
0.011989857,
0.01782027,
0.028296588,
-0.020360382,
-0.021518568,
-0.0061824755,
-0.0005309723,
0.009061489,
0.024782548,
0.018530976,
-0.011956953,
0.008686394,
-0.018096656,
0.04777517,
0.002765498,
0.0041589406,
0.0040733926,
-0.000795019,
0.030376058,
-0.00053385133,
0.005162482,
0.014766871,
0.0063042166,
0.011595021,
0.0032524625,
0.022887334,
-0.007258404,
-0.016569955,
-0.00015793445,
-0.013595523,
0.030349737,
0.0025845314,
-0.00013017253,
-0.013635008,
0.0038397813,
-0.003987845,
-0.004675518,
0.010509222,
-0.023453265,
-0.0007098824,
0.016635763,
-0.020097159,
0.019504905,
0.0098248385,
0.00289711,
0.0069951797,
0.019439097,
0.01443784,
0.0052118367,
0.0030632701,
-0.037562076,
-0.026177635,
-0.004708421,
0.0015217642,
0.021729147,
0.04337933,
0.003586428,
0.008752201,
0.0011450248,
-0.016135637,
0.015780283,
-0.025980217,
0.0062910556,
0.0061462824,
0.013766619,
-0.025730154,
0.021163216,
-0.0018228268,
0.016859502,
-0.013411267,
-0.0009147037,
0.003127431,
0.018004527,
-0.001404136,
-0.022874173,
-0.008870652,
0.036219634,
-0.016885825,
-0.003180076,
-0.018320397,
0.0028016912,
0.030455027,
-0.018241428,
0.018649425,
0.011858244,
-0.009331293,
0.016267247,
-0.023505911,
0.06996496,
0.0108645735,
-0.005346739,
0.02359804,
-0.020307738,
-0.020899992,
-0.124031186,
-0.03803588,
0.004349778,
0.007126792,
-0.0062219594,
0.020386705,
-0.0018557297,
0.024545645,
-0.0036719758,
0.02874407,
-0.02863878,
-0.0025220157,
-0.0023130816,
-0.006916213,
0.021768631,
-0.022242434,
0.025216866,
-0.024519322,
0.00022826463,
0.029270519,
-0.0024019198,
-0.014819516,
-0.02447984,
-0.0031175602,
0.017530724,
-0.001448555,
-0.02874407,
0.014766871,
0.006876729,
0.02404552,
-0.0018771167,
0.0008139382,
0.004655776,
0.00808756,
-0.0032919461,
-0.0071399533,
-0.002722724,
-0.04161573,
0.038536005,
-0.01530648,
-0.006830665,
0.011516053,
0.0439321,
0.016254086,
0.01826775,
-0.007824336,
-0.013108559,
-0.0016764083,
0.0024611452,
-0.01660944,
-0.017372789,
-0.0152011905,
-0.030586638,
-0.03103412,
0.033271525,
-0.0034416548,
0.0033264942,
0.029586386,
0.0011458474,
-0.00033684456,
0.022900496,
0.02437455,
-0.0037575238,
0.011489731,
0.009989354,
-0.019491743,
-0.027191047,
-0.034613967,
0.029165229,
-0.01705692,
0.005540867,
0.027743818,
-0.000923752,
-0.026980469,
-0.030876184,
0.01913639,
-0.010068321,
-0.023374299,
-0.03145528,
-0.0032195596,
0.0028559812,
-0.0118056,
0.032192305,
-0.0022949849,
-0.00546519,
-0.022887334,
0.015372287,
0.007666401,
-0.0067220847,
-0.003124141,
-0.0062680235,
0.025901249,
0.018412525,
-0.022097662,
-0.015424931,
0.013384945,
0.002329533,
0.007093889,
0.032323916,
0.011094895,
-0.0036686857,
-0.01705692,
-0.043274038,
0.0048499038,
-0.001706021,
0.016425183,
0.021768631,
-0.021255344,
0.011009347,
-0.0060640248,
-0.0071004694,
0.002099212,
-0.015477576,
0.010232836,
-0.006156153,
-0.013595523,
-0.030323414,
-0.02633557,
0.017622853,
-0.01584609,
0.012562369,
0.020715736,
0.0009418487,
0.012601852,
-0.015898734,
0.024427194,
-0.0024529195,
-0.012733465,
-0.009541873,
0.037562076,
-0.012121469,
-0.020241931,
0.015030095,
-0.032981977,
-0.0042773914,
0.004188553,
-0.016688406,
-0.018925812,
0.005412545,
0.03835175,
0.021163216,
0.03595641,
-0.0070544053,
-0.021913406,
0.0045439056,
-0.010772445,
0.009712969,
-0.019202197,
-0.041799985,
-0.01279927,
0.005632995,
-0.049749352,
0.015214352,
0.015503898,
-0.0074360804,
-0.018991617,
-0.019110069,
-0.0010372674,
-0.017912399,
-0.0054257065,
-0.02175547,
-0.034245454,
-0.00045406155,
0.028164977,
-0.0010150579,
-0.03061296,
-0.011338377,
-0.005106547,
-0.035377316,
-0.0010249288,
0.0026667889,
-0.0203209,
-0.037061952,
0.012812432,
0.026467182,
0.0051131276,
-0.0035765572,
-0.008021754,
-0.028296588,
0.0016492634,
-0.012687401,
0.0108645735,
0.030586638,
-0.004675518,
-0.018873166,
0.014490485,
0.020794703,
-0.014240422,
-0.006929374,
0.015240674,
0.014898483,
0.0019215358,
0.008567944,
0.006330539,
0.022545142,
0.007113631,
0.011516053,
0.040483862,
-0.010621091,
-0.0026602084,
-0.008048076,
0.03150792,
-0.0012149436,
0.017083243,
-0.0012215242,
-0.01912323,
-0.002995819,
0.038614973,
-0.014108811,
-0.0428792,
-0.009153618,
-0.0017487949,
0.0032179144,
0.006294346,
0.016096152,
0.010917218,
-0.008949619,
0.022018693,
-0.009910387,
0.025901249,
0.00047750495,
-0.000102153565,
0.006383184,
-0.0035831379,
0.0065312474,
-0.015885573,
-0.008771942,
-0.0017603111,
0.011450248,
-0.032481853,
0.031007797,
-0.024993127,
0.046748597,
0.006550989,
-0.040957667,
-0.026006538,
-0.026638277,
-0.043247715,
-0.007949367,
0.023966553,
-0.02905994,
0.08412641,
0.0090812305,
-0.0076334984,
-0.0068504065,
-0.00852846,
0.02950742,
0.0009805097,
0.013950876,
-0.044616483,
-0.008179688,
0.032481853,
-0.015714478,
-0.000890849,
-0.048828065,
-0.022834688,
0.033297844,
0.0041062958,
-0.0106671555,
0.0115094725,
-0.007390016,
0.012601852,
-0.012233339,
-0.009410261,
-0.0011080089,
-0.028507167,
-0.010351287,
0.032087017,
0.007988851,
-0.007021502,
-0.023361137,
0.011562117,
-0.013595523,
-0.03682505,
0.0059258323,
0.020255093,
-0.0059653157,
-0.009436583,
-0.017254338,
0.016648922,
0.02359804,
-0.016490988,
0.0132928165,
-0.014635259,
0.012457079,
-0.0061758948,
-0.026585633,
-0.0076993043,
0.0023657265,
-0.019531226
] |
The incidence of chronic kidney diseases is increasing worldwide, and these conditions are emerging as a major public health problem. While genetic factors contribute to susceptibility and progression of renal disease, proteinuria has been claimed as an independent predictor of outcome. Reduction of urinary protein levels by various medications and a low-protein diet limits renal function decline in individuals with nondiabetic and diabetic nephropathies to the point that remission of the disease and regression of renal lesions have been observed in experimental animals and even in humans. In animal models, regression of glomerular structural changes is associated with remodeling of the glomerular architecture. Instrumental to this discovery | [
0.011615272,
-0.019493977,
0.03135525,
-0.030318053,
-0.0018383644,
0.020677444,
-0.011854624,
-0.0021076365,
-0.039227307,
-0.002712668,
0.009707096,
0.010086072,
0.015863787,
0.016196223,
-0.015544651,
-0.017858397,
0.05015776,
-0.007519675,
0.028536202,
0.008277627,
-0.029068097,
0.014281399,
-0.0040656775,
-0.02340341,
-0.025637371,
0.0078055686,
0.022352915,
-0.050370518,
0.0032977532,
-0.032020118,
0.0047272225,
-0.0041288403,
-0.025956508,
-0.011954355,
0.007446539,
0.016807903,
0.0041122185,
0.013270797,
0.003773135,
-0.029679779,
0.029706372,
-0.00052524696,
-0.010777536,
-0.0030816705,
-0.023270436,
0.012366574,
0.034839164,
0.0061134757,
-0.018270615,
0.014946268,
0.015079242,
0.00026823333,
0.00078205287,
-0.002494923,
-0.007606108,
-0.0021225961,
0.0061965846,
0.023270436,
-0.0051261443,
-0.023815628,
0.006572236,
0.013789395,
-0.017140338,
0.00030542447,
-0.014560644,
0.016222818,
-0.00078413053,
0.014042046,
0.0046008974,
-0.0073601063,
0.032232877,
0.040158123,
-0.006126773,
-0.014640428,
0.01315112,
-0.01642228,
-0.00835741,
0.0016015046,
-0.018190831,
0.0039227307,
0.0061866115,
-0.021555072,
-0.018376995,
0.0071872403,
0.0056779864,
-0.0139356665,
-0.014467562,
0.014201614,
0.0010089396,
-0.009368013,
-0.011189755,
0.008603413,
0.003583647,
-0.006299639,
-0.021116259,
0.0053555244,
0.0067583993,
0.03002551,
-0.011987599,
-0.015185622,
-0.028961718,
0.027259653,
-0.007080861,
-0.015225514,
-0.033988133,
0.016302602,
-0.010930456,
-0.021275826,
0.017552556,
-0.006419316,
-0.03247223,
0.046780225,
0.011209701,
-0.033456236,
0.021887507,
-0.013044741,
0.020584362,
-0.016847795,
0.0028805474,
-0.004368193,
0.012984903,
0.007892002,
0.020504577,
-0.010411858,
0.02227313,
0.027977712,
-0.026594784,
0.0074199447,
-0.016701523,
-0.0051294686,
-0.018257318,
0.013696313,
0.013117877,
0.019999277,
-0.016488766,
0.01620952,
-0.0140287485,
-0.019201433,
-0.02741922,
-0.03970601,
-0.00016891843,
0.016289305,
-0.03930709,
0.006545641,
-0.0007629378,
0.03441365,
0.013417068,
0.0024035035,
0.005415363,
0.0010280546,
-0.0046374653,
-0.0049266834,
0.013596583,
-0.02324384,
-0.006136746,
0.0059406096,
0.008138004,
0.039626226,
-0.036780585,
0.011661813,
-0.012625873,
-0.007858759,
0.0049266834,
0.0005742811,
0.0003924808,
0.021807723,
0.007127402,
-0.0036168904,
0.0041554347,
0.003736567,
0.0010230681,
0.029280856,
-0.025158664,
0.014999458,
-0.0039991904,
0.0071606454,
-0.012479602,
0.0067617237,
-0.049359918,
-0.0014494157,
-0.022565674,
0.012838632,
0.020305118,
0.005707905,
-0.014706915,
0.010584724,
0.03342964,
-0.010052828,
-0.008377356,
-0.010558129,
0.0014344561,
0.0085834665,
-0.023616167,
-0.03457322,
-0.6501893,
-0.03170098,
0.027007002,
0.0042485166,
0.0080515705,
0.02941383,
0.035078518,
0.01503935,
-0.000013310378,
0.013343932,
-0.006020394,
0.02232632,
-0.0050796038,
-0.024201253,
-0.00037087256,
-0.021209339,
-0.015571246,
-0.022632161,
0.016688226,
-0.002034501,
-0.0033758753,
0.0056314454,
-0.00871644,
0.0099398,
0.011615272,
0.016435577,
0.007825515,
-0.01840359,
0.0149329705,
0.01743288,
-0.01203414,
0.009560824,
-0.020557767,
0.012878524,
0.05366827,
-0.019666841,
0.013776097,
0.0088627115,
0.016488766,
0.039679416,
-0.012552737,
-0.0036534583,
0.038216703,
0.01442767,
-0.005299011,
0.023017785,
0.02604959,
0.0062763686,
0.015611137,
-0.00088095217,
0.020890202,
0.022805026,
-0.014613833,
-0.014254804,
0.028137282,
0.015890382,
0.014494156,
-0.027179869,
0.0016447211,
-0.008603413,
-0.0031714279,
0.0015981803,
-0.0016995729,
0.008337464,
-0.012446359,
0.0033609157,
-0.019746626,
0.003497214,
-0.005648067,
0.014760105,
-0.0001977987,
0.039333683,
0.006691912,
-0.009826773,
0.020757228,
0.0066786148,
-0.002110961,
0.017978074,
-0.02589002,
0.00092416874,
0.00067692035,
0.0019630275,
-0.0076592974,
0.005618148,
0.011016889,
0.00087762787,
-0.009102064,
0.024453903,
0.013696313,
-0.0006831535,
-0.0019065135,
-0.0070476173,
-0.01575741,
-0.03156801,
-0.024094874,
0.03547744,
-0.03436046,
0.016861092,
0.010132613,
-0.0064359377,
-0.02324384,
-0.02604959,
-0.008696494,
0.011309432,
0.015637733,
0.012905119,
-0.027046895,
0.026315538,
0.032950938,
-0.014055343,
0.012413115,
-0.022047075,
-0.016488766,
-0.038881574,
0.027738359,
-0.015916977,
0.008902604,
-0.026927218,
0.014055343,
-0.017153636,
-0.013776097,
0.006612128,
0.023523085,
-0.00256141,
-0.007519675,
0.0010679468,
0.0042850845,
0.0059838262,
0.00835741,
-0.043056954,
-0.0014460913,
-0.0055483365,
0.03241904,
-0.014879781,
0.02100988,
-0.023257138,
0.013802692,
-0.00065946754,
-0.0067617237,
-0.029706372,
0.007426593,
-0.017831802,
0.011502244,
0.0021741234,
0.008317518,
-0.012140519,
-0.012659117,
0.004308355,
0.005368822,
0.004424707,
0.0049167103,
-0.00922839,
0.0027243032,
0.04287079,
-0.011302783,
-0.0022971244,
0.008344113,
-0.03446684,
-0.013922369,
0.007499729,
0.01152219,
-0.009062172,
-0.04098256,
0.0016197885,
-0.009461094,
-0.052019395,
0.0030833327,
0.021581667,
-0.042126138,
-0.0103919115,
0.004953278,
-0.007971786,
-0.021329015,
0.02406828,
-0.003726594,
-0.0024118144,
-0.009840069,
-0.0062963148,
-0.015717518,
0.000023088634,
0.0016422279,
-0.039440062,
-0.029679779,
-0.00397592,
0.0183504,
0.0148398895,
0.028615987,
0.029387236,
0.0076526487,
0.036115717,
-0.038216703,
0.017392987,
-0.024507092,
0.005525066,
0.0035670253,
-0.019507274,
0.022472592,
-0.00033929126,
-0.0045211134,
0.0148398895,
0.021023177,
-0.0361955,
-0.01356334,
-0.037791185,
0.026594784,
-0.03047762,
-0.006994428,
-0.00988661,
0.00785211,
0.0052757403,
-0.0033044019,
0.010371965,
-0.012419764,
-0.019148244,
-0.010425155,
0.02696711,
0.00085768173,
-0.031275466,
-0.027033597,
-0.01636909,
-0.0007122415,
-0.0024068279,
0.03686037,
-0.009746988,
-0.041009154,
0.022445997,
0.0013097931,
0.03542425,
0.014799997,
-0.013064687,
-0.014015451,
0.006688588,
0.024094874,
-0.0012524481,
-0.024999097,
0.014640428,
0.0030816705,
-0.028403228,
0.028084092,
0.013596583,
-0.008058219,
-0.015624435,
0.0021924074,
0.014068641,
-0.008251032,
-0.0062165307,
0.02232632,
0.019201433,
-0.0031182384,
0.03191374,
0.005072955,
0.014055343,
-0.008423897,
-0.01585049,
0.0005946427,
-0.008955793,
0.01850997,
0.002245597,
0.056912836,
0.0133572295,
0.018416887,
-0.0029503587,
-0.005305659,
-0.00008108292,
0.015358487,
-0.010352019,
0.029041503,
-0.022339618,
0.012978254,
0.011994247,
-0.0489344,
-0.012140519,
0.005791014,
-0.017419582,
-0.014467562,
0.01121635,
0.019799815,
0.019228028,
0.021555072,
0.013736205,
-0.010046179,
-0.002923764,
0.017924884,
0.009294877,
-0.0074664853,
-0.019440787,
-0.0034174297,
0.004570978,
-0.0036168904,
0.005927312,
-0.0059306365,
0.0065389923,
0.005152739,
0.0010920482,
-0.0010637913,
-0.0076858923,
0.012127222,
-0.008018327,
-0.0072603757,
-0.0031481574,
0.0070675635,
-0.006755075,
-0.016448874,
0.0155579485,
0.018576456,
0.010465047,
0.006239801,
0.012546089,
-0.01126954,
-0.01473351,
0.008397303,
-0.012273492,
0.008663251,
0.008244383,
0.009308174,
-0.011582028,
0.0056779864,
0.0016389035,
0.0051394417,
0.023576275,
-0.0018267292,
-0.0356902,
-0.010125964,
0.006299639,
0.030663785,
0.023084272,
0.01294501,
0.031115897,
-0.0059871506,
0.05215237,
-0.007872056,
-0.044732425,
0.042498462,
0.007978435,
-0.016222818,
0.010644562,
0.0024716526,
0.0064159916,
0.00137628,
0.01590368,
0.0030467648,
-0.03002551,
-0.006462532,
0.0077789742,
-0.00019250052,
-0.006854805,
0.030105295,
0.028376633,
0.0061666653,
0.0009449459,
0.010292181,
0.014706915,
-0.0047205742,
-0.008809522,
-0.011994247,
0.019759923,
-0.0029121288,
0.015770707,
-0.009700447,
0.007759028,
0.028403228,
-0.009102064,
0.0331371,
-0.00019250052,
0.017260015,
0.017579151,
0.021049771,
0.016807903,
-0.0011444067,
-0.011429108,
0.0016280994,
0.012207005,
-0.009640609,
-0.0041986513,
-0.0024483823,
-0.00367008,
-0.008683196,
-0.019746626,
0.02991913,
-0.0025298288,
0.03358921,
-0.0033176993,
-0.0059140148,
0.00083773566,
-0.021727938,
-0.011695056,
-0.0037997297,
-0.02237951,
-0.031062707,
-0.0011036835,
-0.0168212,
-0.00061791315,
-0.023895413,
0.00734016,
0.028695771,
-0.026807541,
-0.021634856,
-0.0046873307,
-0.0027558843,
0.017499367,
0.014999458,
-0.020464685,
-0.00046707087,
0.01370961,
-0.009128659,
0.0030052105,
0.0068814,
-0.02493261,
0.0054386333,
0.0032977532,
-0.022818323,
-0.014042046,
-0.025916616,
0.0004861859,
-0.018004669,
-0.027286248,
0.025424613,
0.0070875096,
-0.018736025,
-0.047391903,
0.022352915,
0.011648515,
0.007253727,
-0.025211854,
-0.005704581,
-0.008270978,
-0.024600174,
-0.038296487,
-0.0005792676,
-0.012831983,
-0.008503682,
-0.029732967,
0.0043615443,
-0.024134766,
0.01692758,
-0.016249413,
0.009035578,
0.0019613653,
0.02656819,
0.006256423,
-0.007765677,
-0.012645819,
0.020172143,
0.008344113,
-0.02135561,
0.0022223266,
0.037392266,
-0.00066860946,
-0.010837374,
0.022632161,
0.009188497,
-0.019068459,
-0.02763198,
-0.018882297,
-0.017100446,
0.0550512,
0.0050097923,
-0.027086787,
-0.022459295,
-0.0040822993,
-0.0059206635,
0.000012881848,
-0.0048036827,
-0.011209701,
-0.0124995485,
-0.013569988,
0.010817428,
0.011409162,
0.030504216,
-0.028456418,
0.004088948,
-0.008124706,
-0.01570422,
-0.0027392628,
0.010518237,
0.013855882,
-0.024693256,
0.004996495,
-0.0025680587,
-0.026009697,
0.0057378244,
-0.003640161,
0.020890202,
0.031594604,
0.019188136,
-0.000038671515,
0.004797034,
0.015212216,
0.013962261,
0.010824077,
-0.0025248423,
0.028669177,
-0.03441365,
0.00014897234,
0.013177715,
0.008510331,
0.0078055686,
-0.012240249,
-0.0077523794,
0.008849414,
-0.0066154525,
-0.012991551,
-0.02085031,
-0.047498282,
-0.018775918,
0.020983284,
0.006572236,
0.0209035,
-0.016794605,
-0.0059106904,
-0.0036035932,
-0.0018982027,
0.013317337,
-0.019892897,
0.014042046,
-0.0061699897,
0.023217246,
-0.0007554581,
-0.007453188,
0.010917159,
-0.018988675,
-0.00020008419,
-0.021249231,
0.007054266,
-0.007845461,
0.01881581,
-0.011196404,
0.018829107,
-0.00087845896,
-0.0060935295,
-0.033403046,
-0.035397656,
0.011488946,
-0.022645459,
0.0058043115,
0.009979692,
-0.030823354,
-0.023257138,
-0.0056015262,
0.010465047,
-0.016302602,
0.012931713,
0.0032512122,
-0.017765315,
-0.0038163513,
-0.019613653,
0.010026233,
-0.018190831,
0.017007364,
0.046274923,
-0.011189755,
-0.018031264,
0.006037016,
0.017499367,
-0.0022555701,
0.031275466,
0.0041388134,
0.01238652,
-0.03186055,
-0.0059406096,
-0.0049300077,
-0.014334588,
-0.04914716,
0.03837627,
0.013643124,
-0.0006931265,
0.0073335115,
0.003018508,
0.0044579506,
-0.0024384093,
-0.018124344,
-0.007825515,
-0.022086967,
-0.008935847,
-0.004863521,
0.0034672949,
-0.015784005,
0.014401075,
-0.013589934,
-0.026195861,
-0.011282837,
-0.01626271,
0.0035902958,
0.016900985,
0.01218041,
0.006392721,
0.00021649816,
0.00014502468,
0.00856352,
-0.0030816705,
0.030344648,
0.011515541,
-0.032897748,
0.04715255,
-0.015744112,
-0.03186055,
0.037046533,
0.0018782566,
-0.019839708,
-0.013363878,
-0.012772145,
-0.023735844,
-0.02819047,
0.016129736,
0.019892897,
0.018696133,
-0.02176783,
0.009201795,
-0.019560464,
0.01728661,
-0.017166933,
-0.0034174297,
0.018416887,
-0.031780764,
-0.009733691,
-0.014374481,
0.022618864,
0.009826773,
-0.009707096,
-0.0063661262,
0.0106246155,
0.018217426,
-0.025065582,
0.019307813,
-0.01870943,
0.010219045,
0.0008472932,
-0.0002698955,
-0.047072764,
-0.021036474,
0.028589392,
-0.013350581,
-0.027711764,
0.009015632,
-0.02248589,
0.011681759,
-0.0038097026,
0.004923359,
0.0147468075,
0.0031032788,
0.023469897,
-0.014414373,
0.0018200804,
0.030211674,
-0.011336027,
0.009401256,
0.013683016,
-0.011914463,
0.018669538,
-0.007905299,
-0.0048203045,
0.018124344,
-0.010046179,
-0.01468032,
-0.04042407,
0.024600174,
-0.02533153,
-0.014055343,
0.0071805916,
0.00017151558,
-0.018044561,
0.003803054,
0.007898651,
0.0056314454,
-0.0024600173,
-0.0058142846,
-0.01101024,
0.024719851,
-0.02503899,
-0.0030982923,
-0.012778793,
-0.019028567,
-0.020065764,
0.0070941583,
-0.015504759,
0.047790825,
0.006163341,
0.0011859611,
-0.013789395,
0.017220123,
-0.029865941,
-0.0071539967,
-0.006462532,
0.0062663956,
-0.0058674742,
0.012559386,
0.012027491,
0.010830726,
-0.034094512,
0.024307631,
0.003736567,
-0.011608623,
0.0048302775,
-0.011615272,
0.02574375,
-0.006153368,
-0.030052105,
-0.00861671,
0.035211492,
-0.018682836,
0.025185259,
0.017525962,
0.0073069166,
0.029334046,
-0.008929199,
0.015863787,
0.007958489,
-0.004015812,
-0.0054519307,
-0.028483013,
-0.012167113,
0.009195146,
-0.0022489214,
-0.011502244,
-0.0035071871,
0.0032844557,
0.008011678,
-0.020637551,
-0.024241146,
-0.007958489,
0.007473134,
-0.0025265045,
0.018496672,
0.0129184155,
-0.00065198774,
0.006066935,
0.024693256,
0.0060037724,
-0.024480497,
-0.007100807,
0.013696313,
-0.0137628,
0.024347523,
0.010385263,
-0.00815795,
0.013643124,
0.0016181263,
-0.012991551,
-0.004059029,
0.0017419583,
-0.01498616,
-0.0033093884,
0.005664689,
0.01269236,
-0.004700628,
0.022140156,
-0.005132793,
-0.022552377,
0.010072774,
-0.0067118583,
0.0102057485,
-0.025969805,
-0.021315718,
-0.006439262,
-0.008324167,
0.021688046,
-0.004368193,
-0.015478164,
-0.02182102,
0.020278523,
0.18690814,
-0.023616167,
0.0043715173,
-0.0031331978,
0.0016605118,
0.014334588,
0.022313023,
-0.0065689115,
-0.012140519,
0.011322729,
0.0058142846,
0.008038273,
-0.03457322,
0.00043133413,
0.005591553,
-0.018137641,
-0.041993164,
-0.010711049,
0.005455255,
0.0027675196,
-0.00785211,
-0.01116316,
-0.002110961,
-0.0030068727,
0.03547744,
0.0061234487,
0.0036135663,
0.02202048,
0.03752524,
0.0070343204,
0.003450673,
-0.005089577,
-0.0033293343,
0.006179963,
0.01218041,
0.011429108,
-0.018536564,
-0.012958308,
0.0032179689,
-0.016488766,
0.008470438,
-0.0045244377,
-0.0029570074,
-0.02335022,
-0.0032844557,
-0.0011194742,
-0.019307813,
-0.020451387,
0.004617519,
0.0027791548,
-0.025823535,
0.0028123984,
0.011808083,
0.0072603757,
-0.0015391731,
-0.004118867,
0.00481698,
0.0057743923,
-0.011462351,
-0.0020594336,
-0.018483374,
0.0033575913,
-0.034653004,
0.019919492,
-0.03574339,
0.03337645,
-0.011794786,
-0.008696494,
0.0024118144,
-0.02604959,
-0.0055849045,
-0.016049951,
-0.017884992,
0.018948782,
0.0046474384,
-0.0149329705,
0.0053289295,
0.021940697,
0.018882297,
0.005551661,
-0.013749503,
0.0073999986,
-0.020092359,
0.0053023347,
-0.022645459,
-0.037844375,
0.020757228,
-0.002358625,
-0.0134503115,
-0.0024650039,
0.00094079046,
-0.023895413,
-0.020118954,
-0.0022090292,
0.017539259,
-0.0052026045,
-0.01177484,
-0.0052890377,
0.008510331,
-0.019520571,
-0.012838632,
0.091113724,
0.014042046,
0.021102961,
-0.009607365,
-0.004268463,
-0.025411315,
0.018044561,
0.009514283,
-0.014095235,
0.016435577,
-0.016555253,
0.011987599,
-0.0133572295,
0.010671156,
0.01565103,
0.012014193,
-0.009500986,
0.0041554347,
-0.006429289,
0.00055558165,
-0.02029182,
0.011974301,
0.0024500445,
-0.022924703,
0.0003463555,
0.015784005,
0.017087149,
-0.02207367,
-0.033881754,
0.0010081085,
-0.037179507,
-0.008091463,
0.001233333,
0.0022505836,
0.009314823,
0.00081488077,
-0.006708534,
0.011754895,
0.016967472,
-0.005598202,
-0.013609881,
0.016728118,
0.007021023,
0.015983464,
-0.0050563333,
0.008703142,
0.0073734038,
-0.010238991,
-0.0019763247,
-0.0007608601,
-0.014095235,
-0.0066786148,
-0.015770707,
-0.002636208,
-0.01865624,
-0.016129736,
-0.028669177,
0.005854177,
-0.0009790205,
-0.027113382,
0.025171962,
0.036089122,
-0.022406105,
0.0013579961,
-0.0045144646,
-0.16744076,
0.010957051,
0.009314823,
-0.020384902,
0.017712126,
-0.010784185,
-0.0040357583,
-0.0012416439,
0.0045809513,
-0.01116316,
0.02997232,
-0.02115615,
-0.020584362,
-0.025158664,
0.0140287485,
0.0053754705,
-0.00010144455,
0.045317512,
0.024560282,
0.022578971,
0.018443482,
-0.015996762,
0.009667204,
-0.019361002,
-0.0014319628,
0.013683016,
0.0031597926,
-0.010524886,
-0.015065945,
-0.009494337,
0.0027110057,
0.020305118,
0.039945364,
-0.0057743923,
-0.0026096131,
-0.008915901,
0.0006652851,
0.00086516154,
-0.0074598365,
0.012240249,
0.017619044,
0.043003764,
0.03047762,
0.007173943,
-0.011076727,
0.03284456,
0.018829107,
0.001003122,
0.012519495,
0.008889306,
0.02385552,
-0.0014984498,
0.013869179,
-0.0037166208,
0.015052647,
0.0017569179,
-0.020677444,
0.026209159,
-0.004414734,
-0.0011485622,
-0.017260015,
-0.016994067,
0.023616167,
0.027286248,
0.014002154,
-0.018124344,
-0.005515093,
0.0060070967,
-0.005697932,
0.0076592974,
-0.02885534,
-0.013363878,
0.00036131506,
0.022219941,
0.02941383,
0.0072670244,
-0.005282389,
0.0163159,
-0.02579694,
-0.026249051,
-0.0134503115,
-0.017818505,
-0.013476906,
-0.008290923,
-0.012885173,
-0.01620952,
0.011754895,
-0.0014627131,
-0.026927218,
-0.012207005,
0.019746626,
-0.03385516,
0.025358126,
0.006000448,
-0.01045175,
0.024148064,
0.0019912843,
0.011475649,
-0.009999638,
-0.008836117,
0.017658936,
0.0006478323,
-0.012293438,
0.009467742,
0.029998915,
-0.006525695,
0.0094411485,
-0.004022461,
0.01748607,
0.0057311757,
0.013237554,
0.018669538,
0.001042183,
0.020810418,
-0.007692541,
0.0089092525,
0.018736025,
0.00221734,
-0.007965137,
-0.029493615,
0.054519307,
-0.007712487,
0.012047437,
0.0052026045,
-0.0028123984,
-0.0045477077,
-0.1335058,
-0.0254911,
-0.0059306365,
0.019028567,
0.0020095683,
0.0058907443,
-0.0029353993,
0.0020095683,
-0.007499729,
0.037498645,
-0.031195682,
0.005704581,
-0.02952021,
-0.019653546,
0.023310328,
-0.0037432157,
0.007872056,
-0.01534519,
-0.024653364,
0.039466657,
-0.0147468075,
-0.011635218,
0.018283913,
-0.01620952,
-0.0045909244,
0.012047437,
-0.020650849,
0.014706915,
0.0025929913,
-0.008603413,
0.012705658,
-0.0006681939,
-0.00018990337,
-0.014667023,
-0.0043548956,
-0.019999277,
-0.0037398913,
-0.0023519762,
0.05292362,
-0.01468032,
0.0014652064,
0.004826953,
0.024374118,
-0.0010571426,
0.0073800525,
-0.014799997,
-0.03981239,
0.02176783,
0.013210959,
-0.008124706,
-0.017818505,
-0.034440245,
-0.030052105,
-0.011754895,
0.014440968,
-0.017153636,
-0.03013189,
0.024028387,
-0.013290743,
-0.0064924513,
-0.02763198,
0.01585049,
0.005235848,
0.012160464,
-0.0053123077,
-0.024653364,
-0.0034407,
-0.033083912,
0.017579151,
-0.020650849,
0.0007903637,
-0.014667023,
-0.021169448,
0.009494337,
0.00016590573,
0.022605566,
-0.004251841,
-0.024453903,
0.022166751,
-0.039360277,
0.00048203045,
-0.0031199006,
0.004979873,
-0.02146199,
0.03970601,
0.011555433,
0.02768517,
-0.010943754,
0.008995686,
0.0024982474,
-0.0239619,
0.021608261,
0.008576818,
-0.027738359,
0.026794244,
0.0052125775,
0.0014984498,
-0.016036654,
0.013895774,
0.018616349,
0.00210265,
-0.007147348,
-0.031381845,
0.0074332417,
0.007646,
0.012858578,
-0.0045942487,
-0.006907995,
-0.005561634,
0.006462532,
0.005495147,
0.019666841,
-0.028775556,
0.017406285,
-0.0077989204,
-0.005062982,
-0.03452003,
-0.008324167,
0.030451028,
-0.00050488533,
0.01876262,
0.019121649,
-0.0006278862,
0.035291277,
0.015105837,
0.0438548,
0.0044080853,
-0.021754533,
-0.020318415,
0.014228209,
0.0027209788,
-0.021036474,
0.011708354,
-0.032924343,
0.014773402,
-0.012718955,
0.015784005,
-0.022765134,
0.0023486519,
0.02646181,
0.028403228,
0.024959205,
-0.0020045817,
-0.02503899,
0.016302602,
-0.0078188665,
-0.011588677,
0.0037099724,
-0.05271086,
0.012931713,
-0.011482297,
-0.03342964,
0.022047075,
0.006821562,
0.00031290425,
0.0003478099,
-0.02936064,
0.008809522,
-0.001672978,
-0.0039925417,
-0.016807903,
-0.0037531888,
-0.0017369718,
-0.0029304128,
-0.02253908,
-0.020916797,
-0.0039227307,
0.011402513,
-0.008683196,
0.017020661,
0.012785442,
-0.01162192,
-0.00093331066,
0.011715002,
0.0037232696,
-0.004577627,
0.015983464,
-0.019786518,
-0.006861454,
0.005043036,
0.00025036494,
0.021222636,
0.030663785,
0.010903861,
-0.02543791,
0.024187956,
0.027951118,
-0.014055343,
0.0054419576,
0.0073069166,
0.01085732,
0.014108532,
-0.016302602,
0.023283733,
-0.00443468,
0.04659406,
0.0060602864,
0.025504397,
0.002466666,
-0.01890889,
0.0027941144,
0.031780764,
0.0033093884,
-0.02554429,
-0.0058707986,
-0.010950402,
-0.014188317,
0.0031697657,
-0.02610278,
-0.027791549,
-0.01370961,
0.0010197437,
0.012605927,
0.0141218295,
-0.011302783,
-0.0026827487,
0.010824077,
0.023416707,
-0.0015557948,
0.00033326587,
-0.012419764,
0.022552377,
0.002953683,
0.027951118,
-0.022871513,
0.00028610168,
0.030929733,
0.01768553,
0.00093995937,
-0.0072404295,
0.02354968,
0.0032744827,
-0.003959298,
-0.013323986,
-0.012366574,
0.00094993244,
0.0018799187,
-0.030823354,
0.012320033,
0.01330404,
-0.0034174297,
0.06478489,
0.00022460126,
-0.025717156,
0.019148244,
0.01198095,
0.017778613,
0.0006125111,
0.019294515,
-0.0065788846,
0.000692711,
-0.0027824792,
-0.010917159,
0.0155579485,
-0.03558382,
-0.008384005,
0.01789829,
0.015996762,
0.0067583993,
-0.010711049,
0.00016923009,
0.014440968,
0.0024217875,
0.0018616348,
0.009933151,
-0.015012755,
-0.0058907443,
0.02763198,
0.0003675482,
0.012672414,
-0.035211492,
-0.02232632,
0.028270254,
-0.013503501,
-0.016541956,
0.028988313,
-0.026940515,
0.0057843653,
-0.017658936,
-0.007074212,
-0.016103141,
0.00259964,
0.019134946,
-0.01850997,
-0.0039061087,
-0.014042046,
-0.02962659,
-0.03481257,
-0.013629827,
-0.017539259
] |
OBJECTIVE To compare contemporary pregnancy outcomes in women with and without type 1 diabetes, and to examine the effects of obesity and glycaemic control on these outcomes. DESIGN AND SETTING Historical cohort study in a specialist diabetes and maternity network in Victoria. PARTICIPANTS All singleton births (at least 20 weeks' gestation), 2010-2013, were analysed: 107 pregnancies to women with type 1 diabetes and 27 075 pregnancies to women without diabetes. Women with type 2 diabetes or gestational diabetes were excluded. METHODS Data were extracted from the Birthing Outcomes System database; associations between type 1 | [
-0.012813824,
-0.02686705,
0.023695245,
-0.0376885,
0.00006278224,
0.0026437258,
0.0051708412,
0.013406872,
-0.032411046,
-0.03984746,
-0.0035682803,
0.019337347,
-0.018857578,
0.009801942,
-0.0034100232,
0.0015184348,
0.042459536,
0.0017374959,
0.013953275,
-0.006776734,
-0.02790655,
0.017058445,
-0.011694363,
0.015166024,
-0.009682,
-0.010674855,
0.005737235,
-0.027879896,
0.0016250501,
-0.026147397,
-0.00711657,
0.012014209,
-0.023641938,
0.0031618094,
-0.018777616,
-0.025227841,
-0.016138889,
0.00210232,
0.016751926,
-0.02173619,
0.016032273,
0.017151734,
-0.0073631178,
0.037581887,
-0.003385035,
0.009801942,
0.0039680875,
0.007043272,
0.010581567,
-0.004950947,
-0.004427866,
0.030038856,
-0.017618176,
0.015605812,
-0.010275047,
0.017911367,
-0.009002328,
0.013266939,
0.0027703315,
-0.04062042,
-0.009555395,
0.015126043,
-0.033317275,
-0.013700063,
-0.005600634,
-0.008795761,
-0.008342646,
0.03307739,
0.0012169135,
-0.005444043,
0.021376364,
0.029825624,
0.0060470854,
0.0011577753,
0.010794797,
-0.02958574,
-0.015632465,
-0.0032001243,
0.015605812,
0.021429671,
0.004461183,
0.0022056035,
-0.00037565228,
0.030545278,
-0.013333574,
0.017045118,
-0.011387845,
0.012314064,
-0.005770552,
-0.03446339,
-0.002836966,
-0.005613961,
0.012953756,
0.019830443,
0.006643465,
0.014646274,
-0.016565349,
0.025827551,
-0.0013235287,
0.0071832044,
-0.0020523441,
0.02277569,
-0.012200786,
-0.02665382,
-0.005314105,
0.0018807602,
0.0010086806,
-0.002200606,
0.012947093,
0.00021323057,
-0.013713391,
0.04632434,
-0.010381663,
-0.0010653199,
-0.020590076,
-0.004507827,
-0.0045044958,
0.003911448,
-0.018524405,
-0.0021306397,
0.025760917,
0.0045911204,
0.036355812,
-0.010315028,
0.01681856,
0.010881422,
-0.033530507,
-0.005663937,
-0.0077962424,
0.0034100232,
-0.013493496,
0.006636801,
0.032704238,
-0.003824823,
-0.01172768,
0.021416344,
-0.025201187,
-0.0045178225,
-0.023228804,
-0.03321066,
-0.007449743,
0.03574277,
-0.0068133827,
0.011267902,
-0.017111752,
0.032384392,
0.024828034,
0.011254575,
-0.019257385,
-0.005663937,
0.005770552,
-0.011381181,
0.004501164,
0.001895753,
0.04123346,
0.0006459387,
0.01992373,
0.03433012,
-0.03683558,
-0.0073897718,
-0.005054231,
0.010281711,
-0.020736672,
0.019297365,
0.009408798,
0.0073431274,
-0.0037082126,
-0.026027456,
0.019643866,
-0.004501164,
-0.010788133,
0.015792388,
-0.018737635,
0.011914258,
-0.0010170098,
0.022269268,
-0.015672445,
0.013993256,
-0.02526782,
-0.020736672,
-0.02256246,
0.03342389,
0.024894668,
0.019403981,
-0.040780343,
0.005514009,
0.010328355,
0.008782433,
0.01114796,
-0.011827633,
-0.0010345014,
0.009428789,
0.0025587666,
-0.0023022238,
-0.65461785,
-0.004477842,
0.021856133,
-0.008196049,
0.01608558,
0.02881278,
-0.004344573,
0.010808124,
-0.013793352,
0.030651893,
-0.00894902,
0.018830923,
-0.0030601916,
-0.008529223,
-0.015086062,
-0.020150287,
-0.002543774,
-0.00547736,
-0.0050775525,
-0.030012202,
-0.014739563,
0.025481053,
0.0037715156,
0.015565831,
0.02225594,
0.009908558,
0.010281711,
-0.010168432,
-0.002430495,
0.024534842,
-0.020470133,
0.007543031,
-0.011960901,
0.010348346,
0.042113036,
-0.027293513,
-0.019030828,
0.017764771,
-0.011414498,
0.016405426,
-0.045657992,
-0.0038314867,
0.0047776974,
0.0048343367,
0.0008362636,
0.0270403,
-0.0053840717,
-0.0014201489,
0.030811816,
0.010381663,
0.013013728,
0.026880378,
-0.02134971,
-0.028013164,
0.0057039177,
-0.020430153,
0.031478163,
-0.008989001,
0.0047876923,
-0.0016542027,
-0.003911448,
0.0020856615,
-0.00055598206,
-0.014912812,
-0.0035183043,
0.023761882,
0.008642501,
0.024081726,
-0.0018241208,
-0.0032467684,
0.009348827,
0.04144669,
0.014113198,
0.00628697,
0.035209697,
0.011201268,
0.021722862,
0.032117855,
-0.015086062,
0.011207932,
0.012360709,
-0.0045511397,
0.015832368,
-0.0033583813,
0.029212587,
-0.0021223105,
-0.005440711,
0.028999357,
-0.0141931595,
-0.020723345,
0.0015567497,
0.013206968,
-0.018870905,
-0.009182241,
-0.0081227515,
0.024828034,
-0.0064368974,
0.0053574177,
0.029958894,
-0.01811127,
-0.03859473,
-0.0053007784,
-0.0045578033,
0.005700586,
0.017138407,
0.018884232,
-0.034516696,
0.028546242,
0.04136673,
-0.022549132,
-0.009082289,
0.0026820407,
0.004081366,
0.010095134,
0.03670231,
-0.032011237,
-0.0054007303,
-0.019950384,
-0.0062170033,
-0.0057172445,
0.016232176,
-0.01074149,
-0.0055906386,
-0.0014401393,
-0.020883268,
0.021029864,
-0.009548731,
0.0009853584,
0.009522078,
-0.017738117,
0.008655828,
0.014899486,
0.024414899,
0.003301742,
0.024214996,
-0.019297365,
-0.009195568,
-0.012320728,
-0.002285565,
-0.023428708,
-0.0017424935,
-0.0029036005,
-0.0036649003,
-0.026040781,
0.013780025,
-0.021642901,
0.00528412,
-0.0022722383,
0.012307402,
-0.0016192195,
-0.0031518142,
-0.030305393,
-0.009981856,
0.011241249,
-0.0067167627,
-0.0153659275,
-0.012913776,
-0.043632302,
0.011714354,
0.021896113,
0.012180796,
0.026533877,
-0.010441634,
-0.02298892,
-0.010215077,
-0.04123346,
-0.03579608,
0.00034441732,
-0.01841779,
-0.015592485,
-0.0028303026,
-0.027693318,
0.011374517,
0.027240204,
-0.004914298,
0.016631983,
-0.011454479,
0.0008162732,
-0.011521114,
0.014926139,
0.0005917981,
-0.0075630215,
-0.03371708,
0.012107498,
0.02811978,
-0.010774807,
-0.009995183,
-0.0042212987,
-0.010488278,
0.019590558,
-0.021269748,
0.031718045,
-0.0031384872,
0.026640493,
-0.0116877,
-0.010408317,
-0.008655828,
-0.007323137,
-0.022349227,
0.013440189,
0.04611111,
-0.012680555,
0.020789979,
-0.001174434,
0.034036927,
-0.01350016,
0.0045278175,
-0.020136962,
0.035822734,
-0.007156551,
-0.00029319202,
0.0051875,
-0.0055839755,
0.0012002549,
0.0010336684,
0.019990366,
-0.016338792,
0.0072298488,
-0.009128934,
-0.0011261239,
0.011234585,
-0.0039914097,
0.018191231,
-0.008209377,
-0.02678709,
0.01565912,
-0.0024404903,
-0.004990928,
-0.0067067672,
-0.011501123,
-0.013047045,
0.0038281549,
0.011900931,
-0.0008595857,
0.00021906108,
0.004721058,
0.019430635,
-0.02410838,
0.0011760998,
0.02445488,
0.0031368216,
-0.011734344,
0.02971901,
-0.013646756,
-0.00748306,
-0.011887603,
0.019657193,
0.014819524,
-0.01911079,
0.0025104566,
0.013446853,
-0.0051541827,
-0.014086544,
0.0044545196,
0.0060437536,
0.007922848,
-0.010781471,
-0.018257868,
-0.00044645148,
0.032544315,
-0.0023072213,
0.01367341,
-0.0068200463,
0.009622029,
0.006063744,
0.014979447,
0.0022272598,
0.0020306879,
0.0050942115,
-0.010888086,
-0.025494378,
-0.004904303,
0.007556358,
0.010788133,
0.016245503,
0.007583012,
0.005074221,
-0.0038414819,
0.03459666,
0.006700104,
0.0019973707,
-0.026067436,
0.015605812,
0.02833301,
0.0056439466,
-0.014153179,
0.010574903,
0.0039547607,
0.00091039453,
0.011754335,
0.019643866,
0.0031934609,
0.016312137,
-0.0125606125,
0.0036349148,
0.009928548,
0.025720937,
-0.021589594,
-0.0020007023,
-0.010494942,
0.024041746,
0.0037115444,
-0.01440639,
-0.0020673368,
0.028226396,
-0.0015167689,
0.0041046883,
-0.0032700906,
-0.01643208,
-0.030518623,
0.0070765894,
-0.021989401,
0.013713391,
0.012600593,
0.012207449,
0.015405908,
-0.010008509,
0.0018824261,
0.011561095,
-0.00047310532,
-0.0071099065,
-0.021882785,
-0.0066201426,
0.0056439466,
0.05741233,
0.040407192,
0.014219813,
0.015299292,
0.0038348183,
0.011874277,
-0.008695809,
-0.019777134,
0.008362636,
0.022442516,
0.016245503,
0.012214113,
0.015032754,
-0.00862251,
0.010921403,
-0.0018790943,
-0.0057438985,
-0.027719973,
0.010521595,
0.010974711,
-0.001296042,
0.0014609625,
0.041393384,
0.006883349,
0.0266938,
-0.022149324,
0.016618656,
0.013686737,
-0.022749035,
-0.0060171,
-0.033877004,
0.019470615,
-0.0031201628,
0.05474695,
-0.010868095,
0.00031755527,
0.030651893,
-0.020163614,
0.04507161,
0.011634393,
0.014326428,
0.006160364,
0.0092755295,
0.0038714674,
-0.011034681,
-0.014819524,
0.0031351557,
0.032357737,
-0.008382627,
-0.018924212,
0.048829798,
0.012040863,
0.0034316794,
-0.033184007,
0.002801983,
0.0011969231,
-0.009215558,
-0.023082208,
0.014872831,
-0.0103416825,
0.00095120823,
-0.024588149,
-0.013766698,
-0.028279703,
-0.018697655,
-0.011980892,
-0.026360627,
-0.010968047,
-0.0270403,
-0.006446893,
0.01807129,
0.0052041584,
0.0020989883,
0.018617693,
0.018830923,
0.0190175,
0.016978484,
0.00912227,
0.019310692,
0.024721418,
-0.02518786,
-0.0077962424,
-0.007223185,
-0.010994701,
0.00418465,
0.002775329,
-0.00068633584,
-0.037768465,
-0.029212587,
0.011467806,
-0.014419717,
-0.0071432237,
-0.008522559,
-0.00012056689,
0.0101284515,
-0.008415944,
-0.005444043,
0.01712508,
-0.018231213,
-0.027693318,
0.0018674333,
-0.0247614,
0.00070715917,
-0.017978001,
-0.010668191,
0.0013151994,
-0.023988439,
-0.009801942,
-0.008889049,
-0.0073164734,
0.01587235,
-0.023855168,
0.019044155,
0.013400208,
0.01828452,
0.046937376,
-0.010321692,
0.024788052,
0.023388727,
-0.018817596,
-0.0045278175,
-0.0160456,
0.008136079,
-0.010088471,
-0.015392581,
0.026800416,
0.0058405185,
-0.0313982,
-0.03467662,
-0.014872831,
0.017364964,
0.022096017,
0.012640574,
-0.0077895788,
-0.0071765413,
-0.008442597,
-0.029292548,
0.002688704,
-0.014393063,
-0.001760818,
-0.00094454474,
0.009935211,
0.00557398,
-0.034783237,
0.05154849,
-0.03643577,
0.00042354586,
0.013433525,
-0.009941875,
0.03696885,
0.0037082126,
0.007356454,
-0.024294958,
-0.016205523,
-0.015605812,
-0.021442998,
-0.0058838306,
-0.009455442,
0.041713227,
0.016711945,
0.023415381,
0.009622029,
0.011034681,
0.0113412,
0.017738117,
0.0334772,
-0.0055539897,
0.019857096,
-0.0026387281,
0.0055939704,
-0.033157352,
-0.0020057,
-0.0123473825,
0.007396435,
0.031078354,
-0.0034583332,
-0.04144669,
-0.0313982,
-0.014912812,
-0.024788052,
0.00012858385,
-0.013260275,
0.006800056,
0.0067933924,
-0.04667084,
-0.014153179,
0.011987556,
0.0099152215,
0.0005359917,
-0.0063302824,
0.016671965,
-0.022375882,
0.029905586,
-0.0153659275,
-0.0003519137,
-0.01405989,
-0.0054873554,
-0.010888086,
-0.017738117,
0.004314587,
0.021949422,
0.017911367,
0.00983526,
0.0038281549,
-0.006087066,
0.022282593,
-0.04835003,
0.0074364156,
-0.0025837547,
-0.018511077,
0.0036115926,
-0.019044155,
-0.02613407,
-0.018644348,
-0.008742453,
0.0059371386,
-0.007649646,
0.015632465,
-0.003521636,
-0.020070327,
-0.028066473,
-0.021749517,
0.019977039,
0.007069926,
0.015619138,
0.015925657,
-0.013433525,
-0.0083693,
-0.0035149725,
0.0073098103,
-0.0057172445,
0.025640976,
-0.012267421,
-0.008675818,
-0.0147262355,
0.0240684,
0.024081726,
-0.02148298,
-0.03934104,
0.010968047,
0.015952311,
-0.026333975,
-0.004121347,
0.006810051,
-0.02449486,
0.01587235,
-0.02294894,
-0.000028319684,
-0.004594452,
-0.008835741,
-0.004781029,
0.03118497,
-0.038621385,
0.048483297,
0.0013793352,
-0.007583012,
0.01041498,
-0.028492933,
-0.009288857,
0.0051541827,
-0.005723908,
0.0012094171,
-0.0021106494,
-0.0038448134,
0.007942839,
-0.011261239,
0.0041346736,
0.00657683,
-0.021109825,
0.03145151,
0.014752889,
-0.0051675094,
0.039181117,
0.0120342,
-0.00854255,
0.00482101,
-0.016125562,
-0.0129870735,
-0.017111752,
-0.010994701,
0.01313367,
0.0047243894,
-0.019044155,
0.006666787,
-0.009395472,
-0.0010053487,
0.002188945,
-0.024521515,
0.0051308605,
-0.02833301,
0.0073631178,
-0.017045118,
-0.027240204,
-0.0018890895,
-0.004211304,
-0.013000401,
0.011561095,
0.0055339993,
-0.024228323,
0.027053628,
0.014433044,
-0.0030385356,
-0.0097552985,
0.011054672,
-0.04339242,
-0.0146196205,
0.016032273,
0.026254013,
-0.0149394665,
-0.0075963386,
0.014952793,
-0.014259794,
-0.014739563,
-0.025254495,
0.021936094,
0.020696692,
0.009422125,
-0.008129415,
-0.012907112,
0.013313583,
0.004841,
0.012407353,
0.007982819,
0.0037348666,
0.014846178,
-0.018857578,
-0.012287411,
-0.010494942,
-0.038701348,
-0.015339273,
-0.02065671,
0.04309923,
-0.009342164,
0.025734263,
-0.02345536,
-0.011914258,
-0.010734826,
0.01884425,
0.013753371,
-0.021536287,
-0.018897558,
-0.0017324983,
-0.008422608,
0.021549614,
-0.014499678,
-0.016098907,
-0.016445408,
0.0051441872,
-0.018324502,
-0.009781952,
-0.009821933,
0.04909634,
0.012567276,
-0.018377809,
-0.02246917,
0.013526814,
-0.023295438,
0.009841923,
-0.01056824,
0.0130403815,
-0.0006655126,
0.013713391,
0.013726718,
0.0127738435,
-0.00070341094,
0.017151734,
-0.052774563,
-0.014393063,
-0.00019802955,
-0.0062936335,
0.05112203,
-0.009162251,
-0.038381502,
-0.008675818,
0.0027186896,
-0.01660533,
0.023415381,
0.00074505754,
-0.004964274,
0.022175979,
-0.013333574,
-0.00854255,
-0.011721018,
-0.0073431274,
0.003824823,
-0.025467725,
0.006213672,
0.0012693881,
0.0023272117,
0.01024173,
-0.050988756,
-0.016178869,
-0.007003291,
0.0061437055,
-0.013166987,
-0.006969974,
-0.026707128,
0.016845215,
0.002103986,
0.009222222,
0.0005822194,
-0.009242212,
0.011747671,
0.008762443,
-0.01056824,
0.013533477,
0.0061103883,
-0.0001572159,
-0.0049309568,
-0.0016808566,
-0.029958894,
-0.01276718,
0.017658155,
0.002543774,
0.015086062,
0.0060670758,
-0.010708172,
-0.016165541,
0.004364563,
-0.002873615,
-0.02134971,
0.0039947415,
0.0031534801,
-0.002655387,
0.009208895,
-0.004241289,
0.0053640814,
-0.020216923,
-0.017538214,
-0.0030235427,
-0.020216923,
0.026947012,
-0.012067517,
-0.014872831,
-0.026760435,
0.00374153,
0.18572381,
-0.005317437,
0.0037881741,
0.029052664,
0.007809569,
0.009735308,
0.031931277,
0.012953756,
-0.0041313423,
0.0048509953,
0.0072298488,
0.000015331152,
0.0064269025,
-0.0012602259,
0.010115124,
-0.019777134,
-0.027186897,
-0.014313102,
0.0020373515,
-0.0152060045,
0.001344352,
-0.0116010755,
0.021642901,
-0.012540623,
0.02958574,
0.009368817,
0.0029036005,
0.0167386,
0.02086994,
0.022029383,
-0.0107148355,
0.0014742895,
0.016098907,
0.037981693,
0.014179832,
0.0008012805,
0.007203195,
-0.027240204,
0.016058927,
-0.0100285,
-0.01729833,
0.0010045158,
-0.024095053,
-0.004900971,
-0.014832851,
0.01244067,
-0.0078562135,
-0.026840396,
-0.012320728,
-0.004887644,
-0.020803306,
-0.012114162,
-0.004924293,
-0.018031308,
-0.0100218365,
0.0025471058,
0.061037246,
-0.007336464,
-0.009068962,
0.022722382,
0.002187279,
0.014486351,
-0.019097462,
0.020843288,
-0.011967565,
0.014513005,
-0.01647206,
-0.023042228,
-0.03411689,
-0.000672176,
0.012207449,
-0.015645793,
-0.018031308,
-0.0019007506,
-0.00862251,
-0.018617693,
0.03342389,
0.021816151,
0.0146196205,
0.0038281549,
-0.011847623,
0.0038015011,
0.0029369178,
-0.018297847,
-0.021789499,
-0.010814788,
0.009075626,
0.0025387763,
0.007969492,
0.0077229445,
-0.00667345,
0.025241168,
-0.026027456,
-0.013979929,
0.009515414,
-0.019177424,
-0.020230249,
0.0071365605,
-0.008769107,
-0.021016536,
-0.009442116,
0.059278097,
0.0042846017,
0.0054940186,
-0.0018591039,
-0.01716506,
-0.010015173,
0.011001364,
-0.0021289738,
-0.016352119,
0.007822896,
-0.0030285404,
0.004231294,
-0.028652856,
-0.010248394,
0.023828516,
0.022056036,
-0.015965639,
-0.0083892895,
-0.006713431,
0.0060337586,
-0.025680955,
0.0049676057,
0.012067517,
-0.02053677,
-0.011421162,
0.003988078,
0.0061936816,
-0.019603884,
-0.013273602,
-0.000072308896,
-0.035902694,
0.006553508,
-0.0007925347,
0.0071432237,
-0.021989401,
0.004471178,
0.010454961,
0.010534923,
0.021602921,
0.0060970616,
-0.011947575,
-0.009781952,
-0.024814706,
0.0022722383,
-0.02700032,
0.023868496,
-0.0149927735,
-0.004697736,
-0.006640133,
-0.00728982,
-0.004694404,
0.0017275007,
-0.026507225,
0.04960276,
-0.0073897718,
-0.012693882,
-0.042592805,
-0.0014193159,
0.008489242,
-0.020456808,
0.008482578,
0.028759472,
-0.018191231,
-0.0050109182,
-0.0032084535,
-0.16877198,
0.031984583,
0.007842886,
-0.018857578,
0.022522477,
-0.0015967304,
0.015339273,
0.0017908035,
0.005467365,
-0.005340759,
0.04291265,
0.008809088,
-0.027693318,
0.016325464,
-0.015739081,
0.0018274526,
-0.021722862,
0.053254332,
0.025947494,
0.013333574,
0.003921443,
-0.0025737595,
0.0012643905,
-0.014899486,
-0.0072565023,
0.037102118,
-0.013833333,
0.046590876,
0.0009770291,
-0.007456406,
0.00017324983,
0.014566313,
0.025760917,
0.00077129493,
-0.0030268745,
-0.0067534116,
0.010408317,
-0.0054607014,
0.01565912,
-0.0016583673,
0.03502312,
0.010688182,
0.0034250158,
-0.0154192345,
0.00072548364,
0.02273571,
0.01643208,
-0.002958574,
0.027853241,
-0.0128271505,
0.02505459,
-0.02717357,
0.007869541,
-0.017444925,
0.0057905423,
-0.0060804025,
0.008675818,
0.0010336684,
0.0026687137,
0.0049309568,
-0.002088993,
-0.051948294,
0.012893786,
0.017018463,
-0.00035274666,
-0.006100393,
-0.0064735464,
-0.013053709,
-0.014872831,
-0.012007546,
-0.04563134,
0.006420239,
0.013513487,
0.0007483893,
0.037901733,
0.014473025,
0.006956647,
0.017311657,
0.017498232,
-0.011327874,
-0.006936657,
-0.01259393,
-0.033397235,
-0.0038947894,
0.010328355,
0.011960901,
0.011880941,
0.029452471,
0.0029768986,
0.008529223,
0.016778579,
-0.038967885,
-0.0027436777,
-0.016565349,
-0.014646274,
-0.00011327874,
0.0057405666,
-0.00305686,
0.027986512,
-0.021243095,
0.017018463,
-0.009761961,
-0.014086544,
0.010841441,
0.004704399,
-0.009288857,
-0.004761039,
-0.00038169103,
0.040140655,
-0.014872831,
-0.018884232,
-0.011021354,
-0.015285966,
0.028786127,
-0.0014268123,
0.030945085,
0.0016958494,
-0.018177906,
0.02902601,
-0.0034816551,
0.023761882,
-0.0031984583,
0.008049454,
0.020057,
-0.0032834176,
-0.00860252,
-0.11194605,
-0.037155427,
0.0019673852,
-0.004601116,
0.00048060168,
0.011114643,
-0.02082996,
-0.0033683765,
-0.005414057,
0.021829478,
-0.020243576,
-0.021616248,
-0.0036482415,
-0.013560131,
0.038035,
-0.022135997,
0.0013560131,
-0.029852279,
-0.0154725425,
0.040647075,
0.010115124,
-0.021336382,
0.0022172646,
-0.018884232,
-0.00028756974,
-0.018444443,
-0.012887122,
0.014113198,
-0.006456888,
0.018870905,
0.004987596,
0.010261721,
0.010948056,
-0.014486351,
-0.011960901,
-0.01807129,
-0.022908958,
-0.02082996,
0.01244067,
-0.022722382,
-0.0012010877,
0.0004964274,
0.018950867,
0.0143530825,
-0.014566313,
-0.0013801681,
-0.014952793,
-0.02306888,
0.014126524,
-0.025401091,
-0.017111752,
-0.0063735945,
-0.0037115444,
-0.016312137,
0.0015059408,
-0.021029864,
0.0022755698,
-0.0059004896,
0.026986992,
0.01988375,
-0.0015584156,
0.037928388,
-0.0064135753,
0.02696034,
0.012467325,
-0.010574903,
-0.017058445,
-0.018910885,
0.003531631,
-0.01608558,
-0.013913294,
0.012953756,
0.0045511397,
-0.0022955602,
-0.0075297044,
0.002703697,
-0.022482498,
-0.009775288,
0.013120343,
-0.016658638,
-0.015952311,
-0.010634874,
0.027093608,
0.009841923,
0.01294043,
0.0033450543,
0.0062070084,
-0.019697173,
0.0021822816,
-0.011561095,
0.008209377,
0.026160724,
0.013593448,
-0.03662235,
0.010654865,
0.006040422,
-0.00675008,
-0.018564386,
0.012320728,
0.0058471817,
-0.019963712,
-0.00574723,
-0.05671933,
0.0233754,
0.0067833974,
-0.008129415,
-0.010488278,
0.0021423008,
-0.00070590974,
-0.00071507203,
0.0038781308,
-0.00042208823,
-0.037768465,
0.022135997,
-0.0141931595,
-0.0012002549,
-0.0122940745,
-0.026054109,
0.004214635,
0.020816633,
0.0141931595,
0.038807962,
-0.0148861585,
-0.01565912,
0.020083653,
0.028492933,
-0.0037182078,
0.00964202,
-0.017938022,
0.00912227,
0.004841,
-0.023615284,
0.021229768,
-0.0131469965,
0.012234104,
0.005317437,
-0.0047776974,
-0.0062403255,
0.013553468,
0.018017983,
0.031718045,
0.019763807,
0.001344352,
0.0014051561,
0.0032984102,
-0.007216522,
-0.021856133,
0.00081710616,
-0.0068566953,
0.019870423,
-0.007129897,
0.0057505616,
-0.012747189,
0.010601557,
0.018057963,
-0.018657673,
-0.00985525,
0.027320165,
-0.0013010396,
0.018337829,
-0.041819844,
-0.0006451057,
0.046430953,
-0.010788133,
-0.011094653,
0.0035982658,
0.030225432,
-0.03097174,
-0.01457964,
0.021842806,
-0.007956165,
-0.019430635,
-0.0076629734,
-0.0034033596,
-0.017831406,
0.017991329,
0.004021395,
-0.0004964274,
0.01841779,
0.022002729,
0.028572895,
0.045951188,
-0.0032834176,
0.0044178707,
-0.041899804,
0.024028419,
0.027213551,
0.005770552,
0.0045911204,
0.013073699,
0.00004289599,
0.0055206725,
0.00057805475,
0.015405908,
-0.023202151,
-0.0018857578,
0.017231695,
0.0150460815,
0.0074164253,
-0.01720504,
0.0063735945,
0.0033217324,
-0.0090089915,
0.0064635514,
-0.0024021755,
-0.016765254,
-0.0057438985,
0.005294115,
-0.014846178,
-0.043499034,
-0.019643866,
0.0062336624,
0.015325947,
0.024175014,
-0.02117646,
-0.0020989883,
-0.011614402,
-0.0046844087,
-0.004524486,
0.020456808,
-0.027266858,
0.018084617,
-0.00520749,
-0.00042895993,
0.011114643,
-0.030438663,
0.027093608,
0.01988375,
0.041766535,
-0.025387764,
0.019937057,
0.012107498,
0.018204559,
-0.010195086,
-0.033583812,
-0.019843768,
0.013193641,
-0.041420035,
0.0154192345,
0.017364964,
-0.0090089915,
0.07052601,
0.019483943,
-0.010701509,
-0.0059471335,
-0.01056824,
0.011001364,
0.025014611,
0.008835741,
-0.019297365,
-0.0029285885,
0.00071215676,
-0.011541104,
-0.01772479,
-0.023868496,
-0.010701509,
0.0007596339,
0.019563904,
-0.020896595,
-0.011554431,
-0.0007404764,
0.0103416825,
-0.0081227515,
0.0082293665,
0.007936175,
-0.0061703594,
-0.015432562,
0.01132121,
0.020110307,
-0.021896113,
-0.03294412,
-0.01741827,
-0.0036382463,
-0.022109345,
-0.013220294,
0.017658155,
-0.011301219,
0.0024987957,
-0.009841923,
0.0150993895,
-0.0045844573,
0.0072565023,
-0.013820006,
-0.04757707,
-0.0066701183,
-0.0341702,
-0.048749838,
-0.00019115787,
-0.012274085,
-0.018644348
] |
The hormonal metabolite of vitamin D, 1α,25-dihydroxyvitamin D3 (1,25D), initiates biological responses via binding to the vitamin D receptor (VDR). When occupied by 1,25D, VDR interacts with the retinoid X receptor (RXR) to form a heterodimer that binds to vitamin D responsive elements in the region of genes directly controlled by 1,25D. By recruiting complexes of either coactivators or corepressors, ligand-activated VDR-RXR modulates the transcription of genes encoding proteins that promulgate the traditional functions | [
-0.030785339,
-0.01836273,
-0.007799641,
-0.021152006,
-0.050620187,
0.036312237,
-0.008451764,
-0.012183711,
-0.02190098,
-0.012538827,
0.015986681,
0.017135967,
-0.015857548,
-0.0024325454,
-0.023011524,
-0.001434992,
0.043311253,
-0.016283687,
0.017174706,
0.0027618348,
-0.004687533,
-0.0064857113,
0.011751115,
0.0020031778,
-0.006285555,
0.013907638,
0.009129712,
-0.044680063,
-0.0014220786,
-0.024690254,
0.009730182,
0.009730182,
-0.0040160404,
0.0012969809,
0.03267068,
0.012558197,
-0.016541954,
-0.027608663,
-0.01085364,
-0.014152991,
0.024251202,
0.0031928166,
0.008994123,
-0.004916744,
-0.0010387147,
0.011266866,
0.028202675,
-0.04493833,
-0.009103886,
0.043905266,
0.00046972177,
0.028512595,
-0.021177834,
-0.028899994,
-0.0050749322,
0.0033477764,
0.03391036,
0.014501651,
-0.00035491434,
-0.02361845,
-0.03460768,
-0.024806473,
-0.016981008,
0.016064161,
-0.0048424923,
0.012048121,
0.01652904,
0.02159106,
0.009187822,
0.013223233,
0.03910151,
0.0126679605,
0.0034349412,
0.01095049,
0.014759917,
-0.005420363,
-0.024315769,
0.012700243,
0.012816464,
-0.005969179,
0.021371532,
-0.006001462,
-0.01073742,
0.017278014,
0.011131275,
-0.005743196,
-0.012299931,
0.030475419,
0.0127196135,
-0.026201112,
0.0057948492,
0.00070942513,
0.031276044,
0.0313277,
-0.01645156,
0.0069473623,
0.037500262,
0.015870461,
-0.022314206,
-0.014488737,
-0.02373467,
0.011305606,
-0.016232034,
-0.016038334,
-0.025400486,
0.009310499,
-0.03538248,
-0.0030265579,
0.014785743,
-0.013662285,
-0.028590076,
0.04945799,
0.0021274684,
-0.04225236,
0.025581272,
-0.005575323,
0.016038334,
0.00884562,
0.0075930282,
-0.009194279,
0.016851874,
0.04400857,
-0.0026407726,
-0.010956946,
0.03352296,
0.011563872,
0.0003064894,
-0.011027969,
-0.0061273673,
0.0075284615,
0.01730384,
-0.013119926,
-0.019692803,
0.008070821,
-0.046978634,
0.0028393148,
-0.012835833,
-0.004693989,
0.003844939,
-0.020183507,
0.012093318,
0.009007036,
-0.031172737,
0.009471915,
0.0162966,
0.025620013,
0.011324976,
0.008484047,
-0.0021193975,
-0.0009886755,
0.002400262,
-0.02147484,
0.015715502,
0.003363918,
0.0004790032,
0.01633534,
0.0022791997,
0.014295038,
0.0064050034,
-0.011002143,
0.038352538,
-0.014837396,
-0.0076769646,
0.0047036745,
0.028667554,
0.03243824,
0.03091447,
-0.0025842767,
-0.01065994,
-0.013946378,
-0.0038513956,
0.018026985,
-0.044654235,
0.015056923,
-0.023515143,
0.014307951,
-0.011964184,
-0.0063275234,
-0.004836036,
0.024974348,
-0.01711014,
-0.007973971,
0.03422028,
0.005378395,
-0.014217557,
0.00841948,
0.0036350975,
-0.009078059,
-0.008393654,
-0.031818405,
-0.00031375315,
0.0069021657,
0.013042446,
-0.025026001,
-0.6429797,
0.0036157276,
-0.0066826395,
-0.0084001105,
0.009213649,
0.017342579,
0.000038311176,
0.008425937,
0.015960855,
0.015069837,
-0.0063113817,
0.019666975,
0.0047359574,
-0.039669696,
-0.03176675,
-0.025968673,
-0.02112618,
-0.02591702,
0.031250216,
0.0036221843,
-0.014191731,
-0.0030862817,
-0.02151358,
0.024625689,
0.021022873,
-0.0012017452,
0.004781154,
-0.0077415314,
0.02840929,
0.037087034,
-0.014437084,
0.025271354,
0.008877902,
0.025594186,
0.045351554,
-0.0046778475,
0.014953616,
0.02732457,
0.019744456,
0.041141815,
-0.036079798,
0.01633534,
0.022585385,
0.0132361455,
-0.030449592,
0.007760901,
0.010801987,
0.019279577,
0.016684001,
0.004203283,
0.010227344,
0.005568866,
-0.01264859,
-0.030836992,
0.017575018,
0.00016575448,
-0.005113672,
-0.011854421,
-0.002566521,
0.013391105,
-0.02108744,
0.0028554564,
0.0076575945,
-0.0047198157,
-0.01069868,
0.016270775,
-0.0011888319,
0.025942845,
0.0048844605,
0.013933465,
0.0055494965,
0.03760357,
0.014901963,
0.009833488,
0.022249639,
0.0024373878,
0.018388558,
0.014617871,
-0.00841948,
0.056715272,
-0.006785946,
-0.009665615,
-0.044292662,
0.0035576178,
0.030191327,
-0.021229487,
-0.013107013,
0.023825062,
0.0008998965,
-0.009872228,
0.01964115,
-0.0113314325,
-0.020751694,
-0.03352296,
-0.009336325,
0.023334356,
-0.007786728,
0.027660316,
-0.004610053,
-0.021035787,
-0.034452718,
0.0070183855,
-0.01878887,
0.005526898,
0.020028548,
-0.012170797,
-0.047675952,
-0.0015358771,
0.038016792,
-0.04576478,
-0.002852228,
-0.0062274453,
-0.021616885,
0.012790636,
-0.009801204,
-0.013429846,
0.017342579,
-0.0044324948,
-0.013429846,
-0.021139093,
0.021345707,
0.0039934423,
0.0054235915,
-0.00032000802,
0.0074509815,
0.004545486,
-0.009691441,
-0.01286166,
-0.009549395,
-0.0017158565,
0.026937172,
0.017355492,
0.015147316,
-0.020958306,
0.017665412,
0.0113314325,
0.017394233,
0.0020903426,
0.00066584273,
-0.025878279,
-0.015302276,
-0.011828595,
0.0011016671,
-0.011286235,
0.0020709725,
-0.004061237,
-0.003294509,
0.017846199,
-0.0036576958,
0.015780069,
-0.003097581,
-0.013391105,
-0.008393654,
0.01457913,
-0.00863255,
-0.0055430396,
-0.0043195034,
0.0043001333,
-0.0037287192,
0.0069861026,
0.01027254,
-0.0034801378,
-0.012287017,
-0.005284773,
-0.03290312,
-0.025026001,
-0.010931119,
0.020829175,
0.0066955527,
-0.03484012,
0.017484626,
0.011822138,
-0.038455848,
0.004571313,
0.002724709,
0.012732526,
-0.0032218716,
-0.00055043,
0.007070039,
-0.009446088,
-0.014592044,
-0.006992559,
-0.03644137,
0.00006285152,
0.023644276,
-0.000506444,
0.019951068,
0.005184695,
0.021152006,
0.006059572,
-0.014876137,
0.021875152,
-0.0022194756,
0.03551161,
-0.00034099218,
-0.045738954,
0.025826626,
0.016981008,
-0.01871139,
0.019240836,
0.02139736,
-0.021526493,
0.030294633,
-0.024509469,
0.01021443,
-0.00051370775,
-0.0058432743,
0.0012533985,
-0.004219425,
-0.0031621475,
-0.0021758932,
-0.012777723,
0.009084515,
-0.009362152,
-0.019899415,
0.02193972,
-0.004451865,
0.014992356,
-0.012635677,
-0.020764608,
0.00070256495,
-0.012209537,
0.02193972,
-0.014062598,
-0.014992356,
0.0106212,
-0.009207192,
-0.006844056,
-0.0022582156,
-0.0065922462,
-0.0057948492,
-0.02280491,
-0.013287799,
-0.013894725,
0.0043808413,
-0.011073166,
-0.016038334,
-0.0162966,
0.0008228202,
0.01038876,
0.016051248,
-0.003618956,
0.033316348,
-0.012558197,
-0.00060046907,
-0.0212424,
0.02303735,
0.0025310093,
-0.021539407,
0.001415622,
-0.0051976084,
0.01291977,
-0.006559963,
-0.00021407852,
0.0019321544,
0.018504778,
0.012119144,
0.011925445,
0.027531184,
0.020144768,
0.03347131,
0.025361747,
0.00859381,
-0.011363716,
0.0015705817,
0.03566657,
-0.0048554055,
0.016283687,
-0.02365719,
-0.032128323,
-0.023127744,
-0.0077544446,
0.009052233,
-0.026859691,
0.011389542,
-0.0037642308,
0.017549193,
0.0036835226,
0.016012508,
0.020222249,
0.012112687,
-0.024793562,
0.020015635,
0.034504373,
-0.0035543893,
-0.009459002,
-0.03788766,
0.009446088,
0.020209335,
0.007973971,
0.010182147,
-0.004819894,
0.015676763,
-0.01473409,
-0.022946957,
0.004603596,
0.02670473,
-0.022288378,
0.011053796,
-0.010453327,
0.0305529,
-0.0022711288,
0.011918988,
-0.009052233,
0.021487752,
-0.004277535,
-0.0015173142,
-0.004032182,
-0.0025455367,
-0.026007412,
0.007463895,
0.018285252,
0.006559963,
-0.03496925,
-0.0048747757,
0.014914877,
-0.00880688,
0.014398344,
0.0042355666,
-0.002506797,
-0.006785946,
-0.020829175,
0.01527645,
-0.0043421015,
0.011990011,
0.00863255,
-0.018620998,
0.016632346,
-0.018453125,
0.0011452495,
-0.008529243,
-0.020441774,
0.0064824834,
0.012383867,
0.0036996643,
0.0075994846,
0.0032525407,
-0.011531589,
0.0070764953,
0.0011347574,
0.0028893538,
-0.018117378,
-0.018892176,
-0.01929249,
0.01079553,
0.009613962,
0.01469535,
0.02962314,
0.034246106,
-0.023437664,
-0.0035931293,
0.02556836,
0.019085877,
-0.033419654,
0.009549395,
0.012028751,
0.0057980777,
0.011873791,
-0.004781154,
-0.034710985,
-0.004493833,
0.007838381,
0.010078841,
0.00822578,
0.0052298917,
0.01243552,
0.013765592,
-0.008484047,
0.0021791216,
-0.006766576,
0.0072314553,
-0.016244948,
0.0042710784,
-0.008839163,
-0.014824484,
-0.01056309,
-0.005714141,
-0.026833864,
-0.037396956,
-0.0021984915,
0.008800423,
-0.021888066,
0.0018562888,
-0.025878279,
-0.0017336123,
-0.010014274,
0.020609647,
-0.023011524,
0.013610632,
-0.008096647,
-0.0072508254,
-0.008090191,
0.013765592,
0.0038643088,
0.007780271,
-0.0293907,
-0.019202096,
0.008877902,
0.001956367,
-0.00097414805,
0.0059336675,
-0.011079622,
0.017639585,
0.003677066,
-0.043078814,
-0.004800524,
-0.0051524118,
-0.0041742283,
-0.016128728,
-0.016025422,
0.021384446,
-0.02151358,
-0.0070571257,
0.0105114365,
-0.00820641,
0.004652021,
0.02514222,
-0.032283284,
-0.014475824,
0.016826047,
0.01882761,
0.022856563,
0.020725867,
-0.010924662,
-0.010743876,
-0.015870461,
-0.008600267,
-0.01711014,
0.0113830855,
-0.014721177,
0.0129004,
0.031508483,
-0.022236725,
-0.026833864,
-0.006863426,
0.00097495515,
0.003325178,
-0.0020774293,
0.009827031,
0.010195061,
0.00411289,
0.003197659,
-0.009936795,
-0.010937576,
-0.00059199467,
-0.02506474,
0.024070416,
-0.0084001105,
-0.03437524,
0.005568866,
0.0033380913,
-0.014269211,
-0.027711969,
0.004958712,
0.03584736,
0.011144189,
-0.0057076844,
-0.035098385,
-0.022417512,
0.029519834,
-0.014592044,
-0.0026536859,
-0.010995686,
-0.004196827,
-0.00038861,
0.004836036,
0.0018740445,
-0.017587932,
0.0032234858,
-0.031973362,
0.0051782387,
0.0028280155,
-0.005604378,
0.022443337,
0.01714888,
-0.020609647,
-0.02709213,
-0.023553884,
-0.01454039,
-0.041735828,
-0.011867335,
-0.011867335,
0.027711969,
0.0088649895,
0.026265679,
-0.0016480616,
-0.0041645435,
0.006805316,
0.012125601,
0.013081186,
0.0065179947,
0.019628236,
-0.031431004,
-0.0066632694,
-0.0015076293,
-0.008329087,
0.03796514,
-0.015521802,
0.028254328,
0.027453704,
-0.011764028,
-0.037035383,
0.004464778,
-0.015780069,
-0.023631362,
0.011318519,
-0.0045487145,
0.0008966682,
-0.015263536,
-0.0010637342,
0.03137935,
0.01073742,
0.026368985,
-0.017717065,
0.013998032,
-0.02709213,
0.024574034,
0.008561526,
0.0061209104,
-0.018737217,
-0.0046261945,
0.014411258,
0.0035188778,
0.027350398,
-0.005342883,
0.021423187,
0.024302855,
-0.010072384,
0.022340031,
0.006876339,
0.004729501,
-0.016593607,
-0.025555447,
-0.012596937,
-0.018220685,
0.009181365,
-0.008716486,
-0.039024033,
-0.005775479,
0.009601048,
-0.02249499,
0.02361845,
0.004839264,
-0.016270775,
0.011182929,
-0.022985697,
0.026962997,
-0.028460942,
0.022843651,
0.020893741,
0.02128114,
-0.011034426,
-0.00828389,
-0.007799641,
-0.01247426,
0.04400857,
0.0013655828,
-0.02494852,
-0.0064534284,
0.0045261164,
0.003935332,
-0.019809023,
-0.02116492,
-0.00067350996,
-0.0075478316,
-0.008994123,
0.007973971,
-0.0041935984,
-0.0017093999,
-0.010182147,
-0.011990011,
-0.004196827,
-0.0023469946,
-0.0071087787,
-0.020183507,
0.024935607,
-0.013326539,
0.0064986246,
0.0013228075,
0.000717496,
-0.018323991,
-0.022662865,
-0.009439631,
0.0170714,
-0.012577567,
0.016890613,
0.0056915428,
0.022081764,
0.00023506265,
0.0035511611,
0.016684001,
-0.016077075,
-0.019821936,
0.03651885,
-0.0021775074,
0.007141062,
0.0325932,
0.020725867,
0.009497742,
0.013455672,
-0.011350802,
0.0053073717,
-0.022146331,
0.006530908,
0.017910765,
0.0075672013,
-0.017239273,
0.01046624,
-0.0070571257,
-0.004438951,
-0.028590076,
-0.0017239273,
0.01301662,
-0.033936188,
0.010382304,
0.0068182293,
0.009613962,
0.010588917,
0.016580693,
0.014152991,
-0.0075349184,
0.0002059068,
-0.020648388,
0.027453704,
0.020118942,
0.021952633,
-0.025749147,
0.0018449896,
-0.020028548,
-0.039643873,
0.030372113,
-0.006117682,
-0.044421796,
-0.013190949,
-0.009762465,
-0.004603596,
0.021758933,
-0.022210898,
0.023282703,
-0.019163357,
0.023954196,
0.013210319,
-0.005946581,
0.010989229,
-0.0006351736,
0.014785743,
-0.007160432,
0.0039095054,
-0.010956946,
-0.026188198,
-0.0034058862,
-0.0031702183,
-0.0065631913,
0.022649951,
-0.02549088,
0.023321444,
-0.013959291,
0.0066438997,
-0.01274544,
0.003954702,
-0.03522752,
0.045661476,
0.013804331,
-0.021139093,
-0.024909781,
0.02031264,
0.018117378,
0.012990793,
-0.008135388,
0.0040289536,
-0.003706121,
-0.023553884,
-0.029907232,
0.009717268,
-0.021423187,
0.0345302,
0.0034930513,
-0.020867914,
-0.0018336904,
-0.012358041,
-0.031095257,
-0.012106231,
0.014824484,
-0.009497742,
0.0047650123,
0.013081186,
0.0071023223,
0.017781632,
-0.0047650123,
0.0018320762,
-0.0012340285,
-0.024483642,
0.012422607,
-0.004309818,
0.04080607,
0.016438648,
-0.029106608,
0.004119347,
0.02545214,
-0.029519834,
-0.022908218,
0.017652499,
-0.012893943,
0.02908078,
-0.019072963,
0.017562106,
-0.0021888067,
0.019770281,
0.027660316,
-0.014346691,
-0.00040233042,
-0.0049393424,
0.0072508254,
-0.014682437,
0.00083613704,
-0.022430426,
0.010324194,
0.023089003,
-0.009736638,
-0.017097227,
0.01038876,
-0.002773134,
0.014837396,
0.021061614,
0.019976895,
0.00627587,
0.012151428,
-0.0067407493,
0.010808443,
0.01067931,
-0.027272917,
0.009620418,
0.005882014,
0.008826249,
0.0045196596,
-0.0077738143,
-0.014798657,
-0.028822515,
0.026523946,
-0.0017642814,
-0.005775479,
-0.026123632,
0.015095663,
-0.004819894,
-0.0056398893,
-0.002527781,
-0.0031734467,
-0.0043905266,
-0.005439733,
-0.00849696,
0.011073166,
-0.0120545775,
-0.011667178,
0.011621982,
-0.023799235,
0.0054300483,
0.014217557,
-0.011621982,
-0.014992356,
0.017897852,
0.18037316,
0.0003476506,
-0.0069473623,
0.0131844925,
0.023050264,
0.0074380683,
0.012467803,
-0.0047553275,
0.0152893625,
0.0009571993,
0.012022294,
0.013003706,
-0.01714888,
-0.006166107,
0.0032702966,
-0.01046624,
-0.022275465,
0.00002051754,
-0.0035543893,
-0.012829376,
0.018879263,
-0.0039676153,
-0.0072314553,
-0.027582837,
0.058884706,
0.022197986,
-0.018969657,
-0.0016044792,
-0.0062209885,
0.013261973,
-0.008038538,
0.0036867508,
0.01481157,
0.013300712,
0.0046197376,
-0.011951271,
-0.013274886,
-0.017097227,
0.004710131,
0.015676763,
-0.00037610024,
0.019434536,
-0.029209914,
-0.022520818,
0.011350802,
0.01652904,
0.0062113036,
-0.021888066,
-0.012306388,
0.0036802941,
-0.0216298,
0.006856969,
0.023205224,
0.026653077,
-0.007922318,
-0.00896184,
0.02419955,
0.016115814,
-0.008664833,
0.027815277,
-0.010053014,
0.0031750607,
-0.017407145,
0.02159106,
-0.0037028925,
0.030836992,
-0.02226255,
0.0024212461,
0.016115814,
-0.013068273,
-0.006214532,
0.015728416,
-0.0153926695,
0.018401472,
0.023386009,
-0.0052363486,
0.01500527,
0.021978458,
0.022146331,
0.01317158,
-0.0074897218,
0.006007919,
-0.030501245,
0.0016149712,
-0.015767155,
-0.026833864,
0.021074526,
0.013972205,
-0.014359604,
0.013126383,
0.01936997,
-0.023218136,
-0.005733511,
0.0018159347,
-0.008128931,
-0.013701025,
-0.01718762,
0.007128149,
-0.0068957093,
-0.01067931,
-0.013261973,
0.08677746,
-0.011467022,
0.018181944,
0.0006932835,
0.0147728305,
0.0053654816,
0.019847762,
-0.004258165,
-0.0014236928,
0.016167467,
-0.022185072,
0.014398344,
0.003906277,
-0.033807054,
0.0017610531,
0.007367045,
-0.02786693,
-0.0033154932,
0.0024357736,
-0.011563872,
-0.028047716,
-0.0075801145,
0.027892755,
-0.01259048,
-0.0032686824,
-0.008729399,
-0.01500527,
-0.0026181743,
-0.032515723,
0.0021306966,
-0.007967514,
-0.0039030488,
0.024212463,
0.0059142974,
-0.01956367,
0.03145683,
-0.012144971,
-0.0041290317,
0.036415543,
-0.010130494,
-0.0017158565,
0.02670473,
0.013520239,
0.0057012276,
-0.026368985,
0.011776942,
-0.000614593,
0.0064889397,
0.02357971,
-0.03024298,
0.00036379223,
0.005242805,
-0.02077752,
0.011944815,
-0.0118996175,
-0.01641282,
-0.04103851,
0.027815277,
0.023902543,
-0.00874877,
-0.011776942,
0.0046487926,
-0.026498118,
-0.011040882,
0.0152893625,
-0.1603317,
0.016270775,
0.043672826,
-0.046126354,
0.016154554,
0.020351382,
0.019666975,
0.0060853986,
-0.0027279374,
-0.0056786295,
0.0258008,
0.00820641,
-0.021152006,
-0.04232984,
-0.0046391077,
0.0004535801,
-0.016684001,
0.026368985,
0.013507325,
0.014320864,
0.03372957,
-0.0057948492,
0.0064953966,
-0.028951649,
0.008677746,
0.009155539,
0.011337888,
-0.004984539,
0.015728416,
0.016089989,
-0.008387197,
0.0151860565,
0.013649371,
-0.008677746,
0.029674793,
-0.022327118,
0.009310499,
-0.0039159623,
-0.016051248,
0.004897374,
0.010808443,
-0.00018996694,
-0.010556634,
0.002547151,
-0.031198565,
0.034246106,
-0.017278014,
-0.0011904461,
0.02237877,
-0.01882761,
0.02884834,
-0.015315189,
0.01929249,
0.019382883,
0.042045746,
0.004839264,
0.006792403,
0.037758525,
-0.01237741,
-0.014359604,
-0.0017610531,
-0.01465661,
0.038636632,
-0.004723044,
0.01036939,
-0.012312844,
-0.017226359,
-0.012777723,
-0.04124512,
0.0059950054,
-0.02993306,
-0.018298164,
-0.021255312,
-0.016089989,
0.013365279,
0.017587932,
-0.009155539,
0.0027553781,
0.0012114302,
0.00845822,
-0.011680092,
-0.009904511,
-0.028228503,
-0.004493833,
-0.04540321,
0.012299931,
0.017084314,
0.030836992,
0.004978082,
0.0063081533,
0.026730558,
-0.02915826,
0.0015721959,
-0.013249059,
0.0086067235,
-0.0007304093,
0.015056923,
-0.00058997696,
-0.013300712,
0.0018223913,
0.02763449,
-0.025155134,
0.002869984,
-0.0034058862,
0.011628439,
-0.011654265,
-0.023076091,
-0.0028489996,
0.03742278,
0.0008732628,
0.014101338,
-0.0041161184,
-0.0065954747,
-0.0010750333,
-0.011764028,
0.021255312,
-0.011499305,
0.0030814393,
0.0107180495,
-0.016671088,
0.048476577,
0.031637616,
-0.00050119794,
0.013061816,
-0.012248278,
-0.029881407,
-0.13264555,
-0.020015635,
0.017781632,
-0.0023970336,
-0.0003906277,
0.038171753,
0.0008506645,
0.00027662737,
0.007483265,
0.008258063,
-0.030088019,
-0.0033510048,
0.0038481674,
-0.014514564,
-0.00032404345,
-0.0056108343,
0.02128114,
-0.011609068,
-0.0218235,
0.045222424,
-0.0052395766,
-0.01500527,
-0.0061144535,
0.00019047137,
-0.013713938,
0.0001012888,
-0.009510655,
-0.00085469993,
0.0012049736,
-0.00025100252,
-0.016180381,
-0.0028506138,
0.027272917,
-0.00529123,
-0.04393109,
-0.02786693,
0.001267926,
-0.011053796,
0.008923099,
-0.0056657162,
0.021332793,
0.009039319,
0.014592044,
0.0071023223,
0.01902131,
-0.004451865,
-0.031585965,
-0.006863426,
0.010421043,
0.019628236,
-0.032980602,
-0.011712375,
-0.023915457,
-0.0172651,
0.0016101287,
-0.017200533,
0.010433957,
0.009149082,
-0.018633911,
0.0056237476,
-0.01307473,
0.018065725,
-0.015857548,
0.006395318,
0.004167772,
-0.02193972,
0.0003222275,
-0.03261903,
0.006098312,
-0.006747206,
-0.010750333,
0.016386995,
0.017678326,
-0.003941789,
-0.019576583,
0.03481429,
-0.025813714,
-0.007812554,
0.005830361,
-0.029003302,
-0.013894725,
-0.014372517,
0.019034224,
-0.0018966428,
0.0018272338,
0.0052524903,
-0.0059853205,
-0.013546065,
0.007031299,
-0.03713869,
-0.042458974,
0.023786323,
0.009646245,
0.005103987,
-0.019589497,
0.0045196596,
0.015366843,
-0.0070442124,
0.0064986246,
0.019434536,
-0.033497132,
-0.02354097,
-0.049561296,
0.017884938,
0.0043808413,
-0.005697999,
0.0055946927,
-0.025284266,
-0.0015939871,
-0.0023582939,
0.00422911,
-0.005830361,
-0.0033703747,
0.0172651,
-0.0047617843,
0.010195061,
-0.012332214,
-0.023747582,
0.034710985,
0.006059572,
0.012067491,
0.023011524,
-0.014604957,
0.008406566,
0.021113267,
0.0019547527,
-0.026304418,
0.00411289,
-0.009052233,
0.0002292113,
-0.0076446813,
-0.0075090914,
-0.0048812325,
-0.04537738,
-0.022094678,
0.012790636,
-0.015818808,
-0.0026262451,
-0.019047137,
0.032412417,
0.010879466,
0.022456251,
-0.024716081,
-0.04426684,
0.0002251759,
-0.0024954977,
0.0022275464,
-0.0025907333,
-0.046823673,
-0.009820575,
-0.01792368,
-0.02334727,
0.007999797,
0.012267647,
-0.009781835,
-0.025335921,
-0.017936591,
-0.014876137,
-0.030423766,
-0.04171,
-0.011053796,
-0.022817824,
0.004426038,
0.030604552,
0.015056923,
-0.025129307,
0.005969179,
-0.032102495,
-0.011550958,
0.0022856565,
0.013778505,
-0.00843885,
-0.044370145,
0.015702588,
0.014359604,
-0.0037577741,
0.0044712345,
-0.007864208,
-0.0015730029,
0.000703372,
-0.013817245,
0.0089682955,
0.00448092,
-0.005462331,
-0.008819792,
0.023024438,
0.022753257,
0.020273902,
-0.017123053,
0.005313828,
0.019421622,
0.011163559,
0.0017255414,
0.0028489996,
0.011944815,
0.025090568,
0.012816464,
0.0012186939,
0.009349239,
0.0041161184,
-0.007334762,
0.028125197,
0.011395998,
0.008942469,
0.012538827,
-0.021526493,
-0.007838381,
0.02747953,
-0.011189385,
-0.047417685,
-0.030991951,
-0.0004959519,
-0.012157884,
-0.008503417,
0.021952633,
-0.0037803724,
-0.0027747483,
0.00822578,
-0.007560745,
0.003815884,
-0.011292692,
0.0256071,
0.01967989,
0.021875152,
-0.0011283007,
-0.0019482961,
0.021539407,
0.00012408887,
0.041632522,
-0.012106231,
0.028925821,
-0.022197986,
0.00057988847,
0.001691644,
-0.00869066,
-0.009969078,
-0.0020306185,
-0.0037900573,
-0.008393654,
0.029752273,
-0.022598298,
0.07753153,
0.011312062,
-0.015676763,
0.0011952885,
-0.014269211,
0.03584736,
-0.010246714,
0.0132361455,
-0.05289293,
0.0008139423,
0.022637038,
-0.013688112,
0.02603324,
-0.018143205,
-0.01975737,
0.031043604,
-0.000100582605,
0.0018159347,
0.009342782,
-0.015844636,
0.006046659,
-0.0054042214,
0.004290448,
-0.0037997423,
-0.049096417,
-0.012906857,
0.042226534,
0.01718762,
-0.0059433524,
-0.040702764,
-0.0039998987,
0.00816767,
-0.035795704,
0.006708466,
0.00011057024,
-0.030346286,
-0.008193498,
-0.00080788916,
0.004445408,
0.030501245,
0.008057907,
0.01738132,
-0.00085792824,
-0.02193972,
-0.011822138,
0.011395998,
-0.022791997,
-0.01894383,
-0.0024696712
] |
A systematic quantitative analysis of temporal changes in host and viral proteins throughout the course of a productive infection could provide dynamic insights into virus-host interaction. We developed a proteomic technique called "quantitative temporal viromics" (QTV), which employs multiplexed tandem-mass-tag-based mass spectrometry. Human cytomegalovirus (HCMV) is not only an important pathogen but a paradigm of viral immune evasion. QTV detailed how HCMV orchestrates the expression of >8,000 cellular proteins, including 1,200 cell-surface proteins to manipulate signaling pathways and counterintrinsic, innate, and | [
-0.0382456,
-0.0077018724,
-0.007761219,
-0.037348807,
-0.00072369905,
0.016181845,
-0.013755227,
-0.014678397,
-0.042597685,
-0.014994912,
0.017447906,
0.016973132,
0.0040223817,
0.0042366893,
0.0013822817,
-0.014625644,
0.03115038,
-0.00460266,
-0.013313425,
-0.034737553,
-0.03816647,
0.012654018,
-0.0033959453,
-0.010154866,
-0.010979124,
0.04228117,
0.006897396,
-0.030200835,
-0.0054170275,
-0.001555376,
0.0026293849,
-0.0064984546,
-0.011368174,
0.0023788102,
-0.0013995911,
-0.023633143,
0.020758128,
0.012166057,
0.02917216,
-0.0024678302,
0.011559403,
0.021760426,
-0.0011523135,
0.011308827,
-0.011084629,
-0.0063401973,
0.014322317,
-0.0008737141,
-0.017302837,
0.0070292773,
0.004150966,
0.00084074377,
-0.0013756875,
0.0025519046,
-0.02003278,
-0.015773013,
0.01529824,
-0.0024942064,
0.014427822,
-0.028618257,
-0.0018727155,
0.010418628,
-0.021918684,
0.011994611,
0.012522137,
0.006650118,
-0.025650928,
0.0024694786,
0.014889407,
0.011922076,
0.022485774,
0.03993368,
-0.022973735,
0.01947888,
0.022644032,
-0.028987527,
-0.03434191,
-0.00053082255,
-0.010280153,
0.01649836,
0.02074494,
-0.021285653,
-0.005571988,
0.012179245,
-0.00073606294,
0.009508647,
0.011988017,
0.019769019,
0.017566599,
-0.007978823,
0.0080183875,
0.0067721084,
0.011579185,
0.01925468,
-0.036768526,
0.02562455,
-0.005746731,
0.039617166,
0.009811974,
0.0152322985,
-0.00022708325,
-0.013359583,
-0.03518595,
-0.020296544,
-0.012621048,
-0.0009940559,
0.011796789,
-0.0054499977,
0.0060995137,
-0.018661214,
-0.024622252,
0.026732355,
-0.026376275,
-0.03674215,
0.024134291,
0.027642336,
0.024727758,
-0.012317721,
0.0033267078,
-0.0009792192,
0.0089877155,
0.0036432229,
0.019571196,
-0.0027777515,
0.04217566,
0.00082013727,
-0.011882512,
-0.0068248613,
0.0018974433,
-0.012363879,
0.026705978,
-0.005974226,
0.0060962164,
0.0091393795,
-0.01982177,
0.031335015,
-0.017962243,
-0.0011630289,
-0.01550925,
0.0018512848,
0.010227401,
0.032310937,
-0.0040553524,
-0.0010270262,
-0.0059841173,
0.0019551413,
0.00642592,
0.02293417,
0.010675797,
0.0023837558,
0.0075106444,
-0.011691283,
0.012344097,
0.008143675,
0.0007917004,
0.019399751,
-0.002741484,
0.017579786,
-0.02988432,
-0.035660725,
-0.014348693,
0.014823467,
0.020520741,
0.0052257995,
-0.0065775835,
0.019703077,
0.023699082,
0.008717359,
0.008493161,
-0.004770809,
-0.018911788,
0.029435923,
-0.028565506,
0.017738044,
0.0018133689,
0.01925468,
0.008915181,
0.008051358,
-0.01359697,
-0.024965145,
-0.008163457,
0.020903198,
0.028934773,
0.0013682692,
-0.030042578,
0.012014393,
0.02435849,
-0.008348091,
0.01437507,
-0.019056858,
0.017329212,
0.010524133,
-0.006343494,
0.00027200533,
-0.6473793,
-0.03199442,
0.010524133,
-0.0052620666,
-0.0021249386,
0.014414635,
0.025743244,
0.0019485473,
-0.022709973,
0.025941066,
-0.020586682,
0.016630242,
0.0037784013,
-0.016880816,
-0.01423,
-0.024820074,
-0.0043850555,
-0.018924978,
0.009007498,
0.0157862,
-0.023356192,
0.0065578013,
0.0075436146,
0.0300162,
0.014757526,
0.011038471,
0.019887712,
-0.018806284,
-0.015601567,
0.037849955,
-0.022498962,
0.028539129,
-0.024160668,
0.0039861146,
0.057764042,
-0.013755227,
-0.014902595,
0.031466898,
0.007497456,
0.018740343,
-0.01806775,
-0.023699082,
0.004807076,
0.01529824,
-0.033260483,
0.024622252,
-0.0030464598,
0.00403557,
-0.022683596,
-0.015667507,
-0.005173047,
-0.02166811,
-0.019030482,
-0.0025997115,
0.00046653036,
-0.009508647,
0.016537925,
-0.028618257,
0.026560908,
0.013379365,
-0.007002901,
-0.006053355,
0.022340706,
-0.02343532,
-0.008664606,
0.009996608,
-0.016115904,
0.00049414305,
0.0033794602,
0.0062610684,
0.025097026,
0.017210519,
0.0014844898,
-0.008644824,
0.004025679,
0.04220204,
0.021470288,
-0.0077810013,
-0.0021463693,
0.00011323253,
0.005182938,
-0.011143976,
-0.034078147,
0.0020276762,
-0.0016963242,
-0.01341893,
-0.028776515,
0.026283957,
0.022973735,
0.022222012,
-0.009350389,
0.018516146,
-0.0011341798,
-0.026086137,
-0.036926784,
0.02988432,
0.007866724,
0.001051754,
-0.014454199,
-0.011460491,
-0.00472465,
-0.024173856,
0.028512754,
0.007095218,
0.00039028644,
0.0076293377,
-0.017751234,
0.005459889,
0.04745092,
-0.0040091937,
-0.012983722,
-0.03708504,
0.0058192657,
-0.020573495,
0.0036794904,
-0.030860242,
0.037322428,
0.010946154,
-0.010201024,
-0.020072345,
0.015416932,
-0.016551113,
0.0034388069,
0.018661214,
0.017645728,
0.02400241,
0.01380798,
-0.017408341,
-0.016986322,
-0.015179547,
0.010853837,
-0.02265722,
0.02909303,
-0.008077734,
0.020059157,
0.008209616,
0.029251289,
0.011374769,
-0.047767434,
-0.03753344,
-0.00050856755,
-0.029462298,
-0.0068908017,
0.020125099,
-0.017764421,
-0.009825163,
-0.008473379,
-0.0005543139,
0.017724857,
0.004533422,
0.008084328,
0.0058324537,
0.012185839,
0.0041707484,
0.01699951,
-0.012245186,
-0.010853837,
-0.03690041,
0.012924375,
-0.01586533,
0.0032080144,
0.020652624,
0.011915483,
-0.007787595,
0.010332906,
-0.006534722,
0.0046323333,
0.00013744512,
0.0022452804,
-0.03051735,
0.019215116,
-0.005555503,
-0.009818568,
0.023817776,
0.017869927,
0.022353893,
0.0060599493,
-0.005077433,
-0.009541618,
-0.014150872,
0.016551113,
-0.019399751,
-0.019294245,
-0.019848147,
0.040672217,
0.02011191,
0.012779305,
0.0028123702,
0.01150665,
0.021325218,
0.024384866,
-0.0039828173,
-0.01622141,
0.017527035,
0.016260974,
-0.010260371,
-0.004899393,
0.027273068,
0.014572891,
0.031071251,
0.01249576,
-0.01784355,
-0.01862165,
0.0034025395,
-0.00079870655,
-0.035133198,
0.0066435244,
-0.027352197,
0.009792192,
0.012568295,
0.007583179,
-0.009033875,
-0.01699951,
-0.006976525,
-0.008440408,
0.013557405,
0.00016021526,
-0.0070358715,
-0.008341497,
-0.009225102,
-0.008440408,
-0.029515052,
0.026560908,
-0.0074447035,
-0.008473379,
0.029910695,
-0.009014092,
0.032231808,
-0.002546959,
-0.003229445,
-0.010313123,
0.006831455,
0.029356794,
0.011348392,
0.020784505,
0.016682994,
0.013834356,
-0.01171766,
0.03384076,
0.02089001,
-0.038008213,
0.0069633364,
0.0018282055,
-0.0057104635,
0.0053181164,
-0.016762123,
0.014441011,
0.00010818394,
0.008809675,
0.004625739,
-0.0033679206,
-0.0075238324,
-0.01614228,
0.0045729866,
0.0036201437,
-0.025162967,
0.0013377717,
0.003554203,
0.053992234,
0.020138286,
0.0024826669,
0.0016295592,
-0.02046799,
-0.012634235,
0.0076029613,
0.0037849955,
0.003089321,
-0.019980028,
-0.020059157,
-0.00824918,
-0.0061588604,
-0.0052455817,
0.008361279,
-0.009409736,
0.0055588,
0.009014092,
-0.0025271769,
-0.0057038693,
0.0043586795,
0.012779305,
-0.03186254,
-0.025901502,
-0.004807076,
-0.002068889,
-0.0070556537,
-0.020850446,
-0.012047363,
-0.012818869,
-0.007101812,
0.0056049586,
0.02492558,
-0.003745431,
0.010385659,
-0.0024777213,
-0.020085534,
-0.009231696,
0.030200835,
-0.009871321,
-0.026152076,
0.0009718009,
-0.021496665,
0.01607634,
-0.023712272,
-0.023343002,
0.019426126,
0.01465202,
-0.025242096,
-0.010049361,
-0.017170954,
-0.00863823,
0.01153962,
-0.01150665,
0.0006717708,
-0.0038641242,
0.0028140189,
0.020718563,
-0.0074183275,
0.0089613395,
0.031546026,
0.017592976,
-0.00018247025,
-0.03547609,
-0.021351594,
-0.013715663,
0.027431326,
0.012621048,
-0.008512943,
0.0315724,
-0.00017649437,
0.0050477595,
-0.031071251,
-0.030464597,
0.035291456,
-0.019637136,
-0.019518444,
-0.0010599965,
-0.00082096155,
0.014269564,
0.01309582,
0.020784505,
0.018094124,
-0.010946154,
0.011064847,
0.028512754,
-0.0036794904,
-0.010385659,
0.021193337,
0.026072947,
0.025242096,
-0.012759523,
0.021694487,
0.02547948,
0.007517238,
-0.023382567,
-0.007009495,
0.016129091,
-0.005087324,
0.003639926,
-0.009897697,
-0.025690492,
0.0003841045,
0.016195033,
0.01897773,
0.012001205,
0.0026508155,
0.025571799,
0.0017227004,
0.027246691,
0.006129187,
-0.0064951577,
-0.008011794,
0.015891705,
-0.008301932,
-0.038140092,
0.022208823,
0.008328308,
-0.007180941,
-0.045630954,
0.0008654715,
0.007866724,
-0.0091657555,
-0.009047062,
-0.01925468,
-0.014836655,
-0.02464863,
-0.021813178,
0.0011267615,
-0.005535721,
-0.012172651,
-0.008163457,
-0.015693884,
-0.017118203,
-0.021259278,
-0.028011603,
0.007846942,
-0.024701381,
-0.02110102,
-0.006650118,
0.008064546,
0.012812275,
0.0039795204,
-0.017170954,
0.0086052595,
0.021734051,
-0.024332114,
-0.013781603,
-0.016379667,
-0.05148649,
-0.0047477293,
-0.01769848,
-0.0060006026,
-0.009113003,
-0.011460491,
0.010827461,
-0.0077150604,
-0.016036775,
0.02089001,
0.014454199,
-0.0007583179,
0.014546515,
0.0070688417,
0.029937072,
0.001963384,
-0.013089227,
-0.0052950373,
-0.044259388,
0.015970834,
-0.027220316,
-0.008209616,
-0.011275858,
-0.005954444,
0.0011597319,
-0.014071743,
-0.03138777,
0.009719658,
-0.002311221,
-0.01550925,
0.007279852,
0.032469194,
0.013372771,
0.0009569642,
0.008479972,
0.012535324,
-0.020217415,
-0.003847639,
0.0034783713,
0.013352989,
-0.008011794,
-0.0031025093,
0.02429255,
0.02238027,
-0.024477184,
0.0013748633,
-0.015970834,
-0.00004979037,
0.033392362,
0.0067787026,
-0.030965747,
-0.031071251,
-0.020626247,
0.009528429,
0.01572026,
0.03136139,
-0.015403745,
-0.008110705,
0.011559403,
0.004919175,
-0.00032517003,
0.008532725,
-0.035502467,
0.0018908492,
0.008420626,
-0.0020804286,
0.0019304137,
0.0017259975,
-0.014282753,
-0.012621048,
0.011420927,
-0.02536079,
-0.03252195,
-0.021074643,
-0.0005411258,
0.031176757,
0.015285051,
0.04531444,
-0.010754926,
0.008585477,
0.012053957,
0.01192867,
0.010557104,
-0.016511548,
-0.0017012698,
-0.0001326026,
-0.00084239227,
0.024688194,
-0.013227702,
-0.021470288,
-0.014955347,
0.005074136,
0.0075238324,
-0.004615848,
-0.016841251,
0.0043520853,
-0.029356794,
-0.0060137906,
0.016696181,
-0.012192433,
0.0004214022,
-0.042940576,
-0.007774407,
0.0077150604,
0.010233995,
0.02096914,
0.018423827,
0.024147479,
-0.0030233804,
-0.0050246804,
-0.020309731,
0.009422924,
0.0077282484,
0.0028799595,
-0.008730547,
0.0032986829,
0.040276572,
0.004737838,
0.012185839,
0.006818267,
-0.0010781302,
-0.0021562604,
0.027853345,
-0.03215268,
-0.036636647,
0.013161761,
-0.025664115,
-0.028882021,
-0.025387164,
-0.0054961564,
-0.03165153,
0.0046850857,
-0.000007682348,
-0.008354685,
-0.007517238,
-0.010029579,
0.00039234708,
0.047055274,
-0.005189532,
0.040645838,
-0.03328686,
0.02740495,
0.020982327,
-0.005726949,
-0.032891214,
-0.01771167,
0.0012108359,
0.013300236,
0.023343002,
0.020204227,
0.011724254,
-0.0005032099,
0.027879722,
-0.010135083,
-0.016551113,
-0.05586495,
0.007378763,
0.0000800046,
0.0033349502,
-0.011203323,
-0.0054203244,
-0.015904894,
0.019623948,
-0.021760426,
0.013649723,
0.0049422546,
-0.005357681,
-0.01037247,
0.010998907,
-0.0052455817,
0.018885413,
-0.013227702,
-0.029726062,
0.015443309,
-0.02499152,
-0.0059841173,
-0.025861938,
-0.021404346,
0.015258675,
0.005097215,
-0.008585477,
0.010121896,
0.001290789,
-0.0010245534,
0.0028634744,
-0.011308827,
0.0352387,
-0.01657749,
0.0018694184,
0.014665209,
0.0014976779,
0.0024612362,
-0.0072864457,
0.005918177,
-0.03434191,
-0.027589584,
-0.0045861746,
0.02648178,
0.02988432,
0.010332906,
-0.000043119027,
-0.00023038028,
0.0070556537,
-0.038799502,
-0.02492558,
0.015205923,
-0.052093145,
-0.00782716,
0.00072205055,
0.022195635,
0.044655032,
0.016366478,
0.005753325,
-0.019637136,
0.029989824,
-0.0093174195,
0.0019617355,
0.021298843,
-0.0068644257,
-0.02824899,
-0.018951353,
-0.028591882,
-0.01228475,
0.025875125,
-0.020375673,
-0.015285051,
-0.015258675,
0.010233995,
0.02591469,
0.012152868,
-0.025690492,
0.010339499,
-0.001224024,
0.0026112513,
0.0007888155,
-0.0017935866,
0.042149287,
-0.019597571,
0.009152567,
0.01947888,
-0.023962846,
0.0053280075,
0.012878216,
-0.01982177,
-0.0031585589,
-0.040250197,
-0.016814874,
-0.02442443,
0.011368174,
-0.0022930873,
-0.006811673,
-0.001580928,
-0.0019996513,
-0.007569991,
-0.0087569235,
-0.0191228,
-0.02293417,
-0.0036695993,
-0.0061852364,
-0.018713968,
-0.012482572,
-0.021048266,
-0.0017424827,
0.0019980029,
-0.032548323,
-0.0065446133,
-0.007741437,
-0.032310937,
0.017395154,
0.009389954,
-0.02236708,
-0.02096914,
0.014282753,
-0.045419946,
-0.008367873,
0.007741437,
-0.0013913485,
0.0049587395,
0.021193337,
0.0009314122,
0.0054137306,
-0.014506951,
0.014361882,
0.001973275,
-0.004962037,
0.00839425,
-0.0015512547,
0.029910695,
0.012159463,
-0.0061489693,
-0.0018578789,
0.0059676324,
0.003923471,
-0.01670937,
0.023751836,
0.005084027,
-0.0032657126,
-0.031203134,
0.0057071666,
-0.010214212,
0.0014441011,
0.0029459002,
-0.022920983,
-0.02236708,
0.0066633066,
-0.026231205,
-0.022855042,
0.01246279,
0.011467085,
-0.009126191,
0.0018545819,
-0.016181845,
-0.054071363,
0.022406645,
-0.0196767,
0.018094124,
0.015812578,
0.007075436,
0.0005506047,
0.027589584,
0.0016682994,
0.004714759,
0.020639434,
-0.0061918306,
-0.0040817284,
0.009976826,
0.0034091335,
-0.009231696,
-0.0072270995,
0.01494216,
-0.000059964812,
0.00096273405,
0.0035113415,
-0.016274162,
-0.03753344,
0.000538653,
0.03376163,
-0.0032376877,
-0.01072855,
-0.0009099815,
-0.020296544,
0.0022007704,
0.011104411,
-0.00902728,
-0.014480575,
-0.006620445,
0.0040124906,
0.006356682,
-0.005674196,
-0.016867628,
0.0009957043,
-0.015562003,
-0.010141677,
0.18779908,
-0.0008967933,
-0.0035970644,
0.002588172,
-0.009159162,
0.01030653,
0.0055093444,
0.0017523738,
0.023395756,
-0.010590075,
0.039538037,
0.0008720656,
0.009680093,
0.0057335426,
-0.006518237,
-0.015852142,
-0.014836655,
-0.020652624,
-0.019386562,
-0.008057952,
-0.0008275556,
-0.009686687,
0.020837257,
0.0026063058,
0.022538526,
-0.0011547863,
-0.0038773124,
-0.0013394202,
0.010603262,
0.0076227435,
-0.025690492,
-0.010379064,
0.00068825594,
0.017738044,
0.008051358,
0.025861938,
-0.004052055,
-0.005928068,
0.0030184349,
0.008117299,
0.015535626,
0.026666414,
-0.0093174195,
-0.01996684,
0.003461886,
0.010445005,
0.0055192355,
-0.012944157,
-0.016379667,
-0.0167885,
-0.031414144,
0.01607634,
-0.011302234,
0.0068380493,
-0.008506348,
0.0019073344,
-0.0072600697,
0.0016402745,
-0.025677303,
0.0325747,
-0.017381964,
0.0089877155,
-0.024477184,
0.018226005,
-0.0010632935,
0.036583893,
-0.0065808804,
-0.00053082255,
0.011256075,
-0.018529333,
0.0082228035,
0.0064720786,
-0.026257582,
0.004615848,
0.0045301253,
-0.0035640942,
0.01670937,
0.015746636,
0.02464863,
0.002304627,
0.00038657727,
0.007846942,
-0.03244282,
0.009132785,
-0.0140849305,
-0.024477184,
0.058924597,
-0.010055955,
-0.009844945,
0.01897773,
0.014572891,
-0.0044839666,
-0.016406043,
0.008809675,
-0.0050345715,
0.009488865,
-0.0085788835,
-0.013320019,
0.026864236,
-0.029620556,
-0.011691283,
0.0713742,
0.01048457,
-0.002359028,
0.019030482,
0.013445307,
-0.02387053,
0.004431214,
0.011111006,
-0.042228416,
0.0014309129,
-0.000040646253,
0.0071743466,
-0.0034454009,
-0.004220204,
0.021641733,
0.013742039,
-0.015377368,
0.030174458,
0.015680695,
0.032231808,
-0.008875617,
0.006594069,
0.0140849305,
0.0057895924,
-0.033893514,
-0.020322919,
0.021813178,
-0.011856136,
-0.035792604,
0.011341798,
0.0010146623,
-0.0045663924,
0.011941859,
0.024806887,
-0.021206524,
0.0095614,
-0.016735746,
-0.0325747,
0.017395154,
-0.025439918,
-0.014717962,
0.00460266,
0.0054434035,
0.013636534,
-0.011585779,
0.011143976,
0.02108783,
0.000717105,
-0.023699082,
0.005176344,
-0.012475978,
-0.00090091466,
-0.016063152,
0.011935265,
-0.022815477,
-0.027721465,
-0.009442707,
-0.006310524,
-0.015891705,
-0.014638833,
-0.0043949466,
0.027141187,
-0.00160648,
-0.0081964275,
0.011414333,
-0.1655375,
0.00059305405,
-0.011262669,
-0.0037849955,
0.0040751346,
0.011704472,
0.017289648,
0.004579581,
-0.02011191,
0.022208823,
0.021931872,
0.0000016452974,
-0.032179054,
-0.02435849,
0.015773013,
-0.017105015,
-0.021931872,
0.020164663,
0.03421003,
-0.011401145,
0.028618257,
-0.016379667,
0.0073457924,
-0.009482271,
0.027141187,
0.02547948,
0.0004949673,
0.015773013,
0.0009610855,
-0.024094727,
-0.011697878,
-0.013194731,
0.026297146,
-0.006244583,
0.013728851,
-0.003758619,
0.0068512373,
0.0080447635,
0.008545913,
0.007563397,
0.041437127,
0.021931872,
0.018740343,
0.009970232,
-0.0021941764,
0.018990917,
-0.007998605,
-0.007385357,
0.00729304,
-0.00034289158,
0.034843057,
-0.019940464,
0.019056858,
0.019505255,
0.016551113,
-0.03180979,
-0.008875617,
0.006524831,
0.011150571,
0.0047774026,
-0.016946757,
-0.017210519,
0.030570103,
0.0014638832,
0.005374166,
-0.037375182,
-0.01818644,
0.0034454009,
-0.0022848449,
0.007945852,
-0.008381061,
-0.00023656222,
0.00087865966,
-0.0034454009,
0.01727646,
0.031941667,
-0.022986924,
0.0010459841,
0.0052950373,
0.0009652068,
0.01806775,
0.005074136,
-0.023422131,
0.0021414238,
-0.0063929497,
-0.014915784,
-0.010253777,
0.011322016,
-0.0035014504,
0.004286145,
-0.016959945,
-0.018990917,
-0.0047345413,
-0.014282753,
0.028196238,
0.02421342,
0.010543915,
0.015878517,
0.009884509,
-0.012528731,
0.008262368,
-0.010240588,
-0.011678096,
0.0155883785,
0.019953651,
-0.007820565,
0.0022320922,
0.013155167,
0.036768526,
0.02025698,
-0.050405063,
-0.0008869023,
0.008882211,
0.019201929,
0.0093437955,
0.00803817,
-0.0063995435,
0.0000793864,
-0.010998907,
-0.018291947,
0.074644856,
0.015021289,
-0.032231808,
0.0053181164,
-0.017527035,
-0.008295339,
-0.14665209,
0.008447002,
-0.0023985924,
0.018107312,
-0.0033679206,
0.041463505,
0.0039696293,
0.008690982,
-0.024543123,
0.024134291,
-0.03315498,
-0.026086137,
-0.0064984546,
-0.028987527,
0.0027101622,
0.0077282484,
0.012053957,
-0.012904593,
-0.02491239,
0.018648027,
0.007596367,
-0.0091657555,
0.010853837,
-0.0049389573,
0.016630242,
-0.0021183447,
-0.0148498425,
0.033313233,
0.0077348426,
0.004127887,
0.019597571,
-0.023039676,
0.014928971,
-0.014533328,
-0.016023587,
-0.00084486505,
0.00472465,
-0.018859036,
0.025400354,
-0.011994611,
0.014164059,
0.016036775,
0.016748935,
0.000019795085,
0.03816647,
-0.0024562906,
-0.028802892,
0.0056774933,
0.0007278203,
-0.010319717,
-0.011440709,
-0.014098119,
-0.03534421,
-0.03539696,
-0.000033408232,
-0.039247897,
0.0020804286,
0.024701381,
-0.01947888,
0.0040025995,
-0.014414635,
0.010346094,
-0.0095482115,
0.01876672,
0.02988432,
-0.02930404,
-0.0032096629,
-0.020507554,
0.024714569,
-0.04022382,
0.008367873,
-0.018344698,
-0.018661214,
-0.016617052,
-0.017025886,
0.004233392,
0.0008753626,
-0.008427219,
0.01348487,
0.0023656222,
-0.014335506,
-0.02059987,
0.019531632,
0.016181845,
0.037638944,
0.02257809,
0.010293341,
0.0023095727,
-0.012251779,
-0.004223501,
0.010695579,
0.042228416,
0.010326312,
0.00056956266,
-0.020626247,
0.0038113717,
-0.015891705,
-0.018120501,
0.013155167,
0.04017107,
-0.01771167,
0.002171097,
-0.04716078,
-0.007167753,
-0.00042160827,
-0.014612456,
0.0010212564,
0.0031453709,
-0.023448508,
-0.0076227435,
0.009640529,
0.03795546,
-0.042518556,
0.014111307,
-0.016260974,
0.013504652,
-0.03165153,
0.012891404,
0.029726062,
-0.0056280377,
0.021773614,
0.028143486,
-0.0029788706,
-0.008493161,
-0.0028601773,
0.0403557,
0.0014572892,
-0.00066641305,
-0.0010979124,
0.010339499,
-0.0068446435,
-0.005367572,
0.012766117,
-0.0022254982,
0.010055955,
0.006521534,
0.009877915,
-0.008447002,
-0.012904593,
0.009779003,
0.005400542,
0.04993029,
-0.030121706,
-0.01359697,
0.0063171177,
0.0007039168,
-0.023844153,
0.016867628,
-0.027009305,
0.0054236217,
0.0063731675,
-0.021892307,
0.02464863,
-0.0051334826,
-0.008499755,
-0.037375182,
-0.008229398,
0.013458494,
-0.016340103,
-0.01366291,
0.0042564715,
-0.018437017,
0.01841064,
0.016590677,
0.015535626,
-0.00786013,
0.004005897,
0.00063797616,
-0.018924978,
0.0029491973,
0.004807076,
-0.014915784,
-0.0058225626,
0.013689287,
0.0005860479,
0.019070046,
-0.010860431,
0.00225682,
0.0085525075,
0.008717359,
0.0030019497,
-0.0067918906,
0.027958851,
0.011302234,
0.0008877265,
0.022314329,
0.019360187,
0.014190436,
0.0061687515,
0.02882927,
-0.0048466404,
0.007833754,
-0.005199423,
0.0150081,
0.0070358715,
-0.003550906,
0.0060863253,
0.0032706582,
0.007095218,
0.017672105,
0.011737443,
0.035818983,
-0.0058357506,
0.008625042,
0.008077734,
-0.0073391986,
-0.013636534,
-0.0040586493,
-0.037507065,
-0.03753344,
-0.0036234409,
0.0049488484,
0.0006977349,
0.006818267,
0.010445005,
-0.00660396,
-0.013768416,
0.0008399195,
0.00962734,
-0.011981423,
-0.020230602,
0.032759335,
0.0034750742,
0.005875315,
0.007009495,
-0.026494969,
0.016063152,
0.017751234,
-0.00046941527,
-0.023092428,
0.02387053,
-0.004507046,
0.005153265,
-0.0063171177,
-0.008348091,
-0.027352197,
-0.008717359,
-0.010576886,
-0.0061159986,
0.0065742866,
0.002457939,
0.07786276,
0.010313123,
-0.0076293377,
0.0017523738,
-0.0325747,
0.0110516595,
0.024121104,
0.013926673,
-0.006785297,
-0.028882021,
0.03476393,
-0.0037256489,
0.014164059,
-0.036293752,
-0.026521344,
0.0012347393,
-0.009976826,
0.006561098,
-0.008453596,
0.0104647875,
0.006439108,
-0.008565695,
0.011236293,
0.0032343906,
-0.020098722,
0.01192867,
0.024187043,
0.014625644,
-0.008479972,
-0.024094727,
0.012818869,
-0.010708768,
-0.02875014,
-0.019294245,
-0.007266664,
-0.016986322,
-0.012278156,
-0.0062280977,
0.004137778,
0.0108736195,
-0.013939861,
0.008268963,
-0.0048433435,
0.004737838,
-0.011592373,
-0.029145783,
-0.023554014,
-0.025123402,
-0.0019089829
] |
Sleep disturbances, including sleep insufficiency and sleep fragmentation, have been linked to abnormal glucose metabolism and increased diabetes risk. Well-controlled laboratory studies have provided insights regarding the underlying mechanisms. Several large prospective studies suggest that these sleep disturbances are associated with an increased risk of incident diabetes. Obstructive sleep apnea, which combines sleep fragmentation and hypoxemia, is a major risk factor for insulin resistance and possibly diabetes. Whether glycemic control in type 2 diabetes patients can be improved by treating sleep apnea remains controversial. Recently, sleep disturbances during pregnancy and their relationship to gestational diabetes and hyperglycemia have received considerable attention owing to | [
0.009474526,
-0.017489497,
0.03241219,
-0.033594932,
-0.00944307,
0.015979612,
-0.013324731,
0.0026029781,
-0.01464588,
-0.01538824,
-0.0032965813,
0.029795056,
0.024837602,
-0.0058979867,
-0.00506755,
-0.008738457,
0.058331873,
0.00036685477,
0.014985604,
-0.0018102888,
-0.03364526,
0.0019691412,
-0.0039571556,
0.010594357,
-0.008751039,
0.016860377,
-0.0057281246,
-0.025089249,
-0.0065805805,
-0.01124864,
0.016118018,
-0.019188117,
-0.03193406,
0.010103644,
0.0025605126,
-0.01979207,
-0.0038156041,
0.004020068,
0.0036646158,
-0.039382823,
0.021113219,
0.0041270177,
-0.0060238102,
0.021629097,
0.0025746678,
0.015979612,
0.027177922,
-0.002634434,
-0.0081848325,
0.020886736,
0.007461346,
0.023931671,
-0.0126264095,
-0.007348105,
0.007882856,
0.011066196,
-0.005221684,
0.027505064,
-0.0032934358,
-0.029191103,
0.011751935,
0.0077004116,
-0.022258215,
-0.0056306114,
0.0009271635,
0.018433174,
0.007788488,
0.01639483,
0.001139491,
0.0053191977,
0.047309715,
0.034425367,
-0.0036268686,
-0.0019455492,
0.007889147,
-0.014809451,
-0.019188117,
-0.019716576,
0.021993985,
0.014092256,
0.008606342,
-0.015375658,
-0.027404405,
0.042226437,
-0.0045548184,
0.013236655,
-0.020496683,
-0.0030543706,
-0.014935275,
0.0005249208,
-0.015526647,
0.0033940948,
0.013224073,
0.004149037,
-0.0049008336,
0.01708686,
0.00045964975,
0.023264805,
-0.004721535,
-0.0031817672,
-0.009260626,
0.027203087,
-0.02276151,
-0.0119658355,
0.0031943496,
-0.023214476,
0.0025872502,
0.008870572,
-0.0013934977,
-0.008191124,
-0.005268868,
0.035054486,
0.0028577712,
-0.027983194,
-0.014280992,
-0.0067944806,
0.010695016,
0.0066309096,
-0.024762107,
-0.035356466,
0.018445756,
0.0121356975,
0.023315134,
-0.008719583,
-0.016407412,
0.005835075,
-0.027882535,
-0.005794182,
-0.011236058,
-0.026347486,
-0.011449958,
0.004976328,
0.022774093,
-0.02737924,
-0.034777675,
0.012834019,
-0.019125205,
-0.028410995,
-0.03213538,
-0.03349427,
0.0011567918,
0.027454734,
-0.031581752,
-0.008304365,
0.0029143917,
0.030726152,
0.022950245,
-0.003922554,
-0.016457742,
-0.00082257256,
-0.0072096987,
-0.0118840495,
-0.008606342,
0.009040434,
0.017917298,
0.021729756,
0.0053821094,
0.025756115,
-0.048718944,
-0.0134505555,
-0.006561707,
-0.010311253,
0.005237412,
0.025718367,
-0.01543857,
-0.0024755816,
-0.010053315,
-0.021402614,
-0.0032902902,
0.0030527979,
0.005152481,
0.01819411,
-0.02954341,
0.01347572,
0.0015098846,
0.02637265,
-0.00043998982,
0.0012448684,
-0.017036531,
-0.02068542,
-0.040917873,
0.021503273,
0.017892132,
-0.0012566644,
-0.032236036,
0.009858288,
0.014079674,
0.008159668,
0.016004777,
-0.02546672,
0.0107327625,
-0.012922095,
-0.011783391,
-0.042352263,
-0.63294363,
-0.0148471985,
0.008474227,
-0.011380755,
0.012909513,
0.025567379,
0.0127081955,
0.008096756,
-0.0022034878,
0.011468831,
-0.0028797903,
0.024372054,
-0.00095626025,
-0.029115608,
0.014469727,
-0.01926361,
-0.009468234,
-0.020345695,
0.0019408308,
0.0018905014,
-0.010638395,
0.00029312994,
-0.0050644046,
0.0074298903,
0.010267215,
0.019804653,
0.023063486,
-0.011707896,
-0.013022754,
0.037998762,
-0.010525154,
0.021616515,
0.0025699495,
0.015224669,
0.054456502,
-0.019880148,
-0.007681538,
0.02785737,
0.014079674,
0.03221087,
-0.011739353,
0.0019046565,
0.02929176,
0.019817235,
0.0161306,
0.010091062,
0.009216587,
-0.0058287834,
0.022975411,
-0.009134802,
0.012538333,
0.023378046,
-0.023264805,
0.00068416644,
0.02515216,
-0.015488899,
0.011701605,
-0.02939242,
0.022459533,
0.008342112,
0.014029345,
0.018080868,
0.002604551,
0.003755838,
-0.028939454,
0.030172527,
0.013060502,
-0.0007852186,
0.013110831,
0.0019455492,
0.0004930717,
0.03729415,
-0.012330724,
0.024346888,
0.026171332,
0.018332515,
0.021792667,
0.04758653,
-0.014595551,
-0.008493101,
0.008832824,
0.019703994,
-0.014268409,
-0.007964641,
0.022660851,
0.009455652,
-0.00025145084,
0.02323964,
-0.019339105,
-0.027781876,
0.018269604,
0.013815444,
0.0056117377,
-0.03427438,
-0.0113052605,
0.028637478,
-0.014029345,
0.008027553,
0.013714785,
-0.0062691667,
-0.022509862,
0.0038816617,
-0.03460152,
-0.0040169223,
0.034928665,
0.005073841,
0.0024158154,
-0.023227058,
0.039533813,
-0.015463735,
0.020194706,
0.000001910702,
-0.0018732005,
-0.027530229,
0.032563176,
-0.012160862,
-0.00037629154,
-0.010393039,
-0.005152481,
-0.022937663,
-0.011714187,
-0.0047844467,
0.00917884,
-0.015451152,
0.0018857829,
0.0031723303,
0.011921797,
-0.016935872,
-0.0083484035,
-0.027253417,
-0.011129107,
-0.0052028107,
-0.0031503113,
-0.008574886,
-0.02536606,
-0.020031136,
-0.0016262715,
-0.013073084,
0.013614126,
-0.042578746,
-0.0107327625,
0.015564393,
-0.0064484654,
-0.007757032,
0.008669254,
0.006335224,
-0.0078073614,
-0.015602141,
0.02520249,
-0.008411315,
-0.0002762224,
-0.036312725,
-0.019590752,
0.02254761,
-0.00769412,
-0.01639483,
0.0046617687,
-0.02457337,
-0.020547012,
0.014268409,
0.021251626,
0.00307639,
-0.014343903,
-0.011896633,
-0.008373568,
-0.047309715,
-0.004551673,
-0.002024189,
-0.04849246,
-0.021943657,
-0.0026674627,
-0.026724957,
-0.0047120983,
0.02881363,
0.0078513995,
0.013236655,
-0.0010223177,
0.0111479815,
-0.016684225,
0.008681837,
0.010669851,
0.010669851,
-0.025655456,
0.0017033386,
0.03978546,
0.0042528417,
0.01660873,
0.0047624274,
-0.0074235993,
0.03236186,
-0.037671622,
0.049046084,
-0.006376117,
0.0024850185,
-0.009405322,
-0.005385255,
0.0011929661,
-0.0119658355,
-0.013765114,
0.023831012,
0.03915634,
-0.03369559,
-0.0074361814,
-0.018370263,
0.049801026,
-0.022245632,
0.011733062,
-0.009984111,
0.013236655,
-0.010311253,
-0.018496087,
0.010783092,
0.010198012,
0.00037963374,
-0.0016435722,
-0.0010718608,
-0.017753726,
0.0036929261,
-0.0028860816,
-0.017678233,
0.0049574543,
-0.0028153057,
0.01708686,
0.0016372812,
-0.02079866,
0.00885799,
0.016847795,
-0.012129406,
0.0198424,
-0.023893924,
-0.023843594,
0.009531147,
0.009984111,
0.01321149,
-0.0024283978,
0.019062294,
-0.002511756,
-0.0200563,
0.026045509,
0.011538034,
0.0027885681,
0.012475422,
0.036891513,
-0.0054796226,
-0.016835213,
0.0067881895,
0.037596125,
0.008499392,
-0.009216587,
-0.008096756,
-0.0077696145,
0.005533098,
-0.01194067,
0.012651575,
0.00045493137,
0.0055268067,
0.013110831,
-0.004366083,
0.045950823,
0.014935275,
0.0074676373,
0.003167612,
-0.022107227,
0.003979175,
0.007524258,
0.013463138,
0.024233647,
-0.006042684,
0.033745922,
0.019351687,
-0.03653921,
0.010122518,
-0.00037353917,
-0.027832206,
0.017816639,
-0.0005221684,
-0.015249834,
0.0045957114,
0.04059073,
0.0049731825,
0.004331481,
-0.029518243,
0.017388837,
-0.000048904138,
-0.01596703,
0.0027492482,
-0.0017363672,
0.010160265,
0.0053632357,
0.011550617,
0.00085324206,
0.001877919,
0.01103474,
-0.03253801,
0.0081848325,
0.0007985874,
0.013412808,
-0.0038156041,
0.019087458,
0.022736344,
0.006542833,
0.030449338,
-0.036514044,
0.019402018,
0.024309142,
0.0053758183,
0.0078010703,
0.0020524994,
-0.008052718,
-0.019213282,
0.01787955,
-0.009166257,
-0.0034507154,
0.011292678,
0.020974813,
0.018546415,
-0.01140592,
0.000042219755,
0.011550617,
-0.00923546,
-0.008719583,
-0.026901111,
-0.019389434,
0.012727069,
0.030499669,
0.020018553,
0.0045642555,
0.035784263,
0.0075934613,
0.015803458,
-0.0065931627,
-0.046705764,
0.0161306,
-0.006681239,
0.0020147522,
-0.015727965,
0.028738137,
0.0026391523,
0.007819944,
0.0052499943,
0.00073606876,
-0.035884924,
0.0021846143,
0.02079866,
-0.0048567955,
-0.009984111,
0.02302574,
0.04101853,
0.040615894,
-0.03193406,
-0.006567998,
0.016206095,
-0.017187519,
-0.01777889,
-0.011739353,
0.014155168,
-0.002960003,
0.048291143,
-0.007354396,
-0.010361583,
0.0040420867,
-0.010952954,
0.015853789,
-0.008549722,
-0.0003196709,
0.03613657,
0.009241752,
0.008864281,
-0.00027523938,
-0.026171332,
-0.0053632357,
0.023101235,
-0.000801733,
0.008600051,
0.018068286,
0.0074047255,
-0.020823825,
-0.00885799,
0.0155895585,
-0.015727965,
0.003353202,
-0.005423002,
-0.012374762,
-0.01146254,
-0.010537736,
-0.00091300835,
0.007272611,
-0.029040113,
-0.020383442,
-0.0032714165,
0.013588961,
-0.0150107695,
-0.028159348,
0.005470186,
0.04149666,
-0.022912499,
-0.017124608,
0.010556609,
0.014608134,
0.012959843,
0.0054135653,
-0.00018794918,
0.0001345724,
0.005979772,
-0.023428375,
0.0017536681,
0.0031896313,
0.00065389014,
0.016797466,
-0.01708686,
0.0049952017,
-0.02742957,
0.00418993,
-0.003545083,
-0.0030732444,
-0.0050423853,
0.009260626,
-0.0075745876,
0.010965536,
-0.02164168,
0.011292678,
0.012714487,
-0.0035136272,
-0.024070077,
0.019980807,
-0.012261521,
-0.0017190665,
-0.02043377,
0.002208206,
-0.005221684,
-0.012500586,
-0.024472713,
0.00795835,
0.003862788,
0.027127594,
0.0012409363,
0.010462242,
0.0025211927,
0.03814975,
0.023101235,
-0.02584419,
0.01321149,
-0.003128292,
0.0005819347,
-0.01730076,
-0.016306754,
0.018206691,
0.0066623655,
0.008618925,
0.012129406,
0.015249834,
-0.013060502,
-0.028763302,
-0.02302574,
-0.03460152,
0.06260988,
0.008071591,
-0.017539825,
-0.047309715,
0.003793585,
-0.011135398,
-0.00939274,
-0.009940074,
0.002209779,
-0.013991597,
-0.019137787,
0.010902625,
-0.037872937,
0.04886993,
-0.03895502,
-0.009537438,
-0.0092543345,
-0.005092715,
0.01575313,
0.0044635963,
0.0069832164,
-0.049046084,
-0.005718688,
-0.020421188,
-0.014809451,
-0.021176131,
-0.016432578,
0.047964,
0.028083853,
0.022132391,
0.016558401,
0.018332515,
0.023742935,
0.013060502,
0.0078010703,
-0.0019282484,
0.010745346,
-0.028209677,
0.0046774964,
0.0011819565,
-0.0015806605,
0.02185558,
-0.0025133288,
0.03772195,
-0.009789085,
-0.022006568,
-0.028889125,
-0.026548805,
-0.017414002,
-0.0035167728,
0.00086975645,
0.01072018,
0.0050266576,
-0.0361869,
-0.02685078,
0.01862191,
0.011751935,
-0.0048316307,
-0.03150626,
0.019628499,
-0.023164146,
0.04217611,
-0.0003560418,
0.007310358,
-0.021968821,
-0.012110532,
-0.00014823607,
-0.012192318,
0.008096756,
-0.0064170095,
0.0097073,
-0.014884946,
0.0066246185,
-0.0058287834,
0.016193513,
-0.011361881,
-0.002162595,
0.011644985,
-0.018433174,
0.0008524557,
-0.016872961,
-0.033771086,
-0.024309142,
-0.019527841,
0.030499669,
-0.023843594,
0.018848393,
-0.018395428,
-0.010795675,
-0.009575184,
-0.0017992791,
-0.010015568,
-0.0050486764,
0.012236357,
-0.0074676373,
-0.01114169,
0.000033938,
0.022157555,
0.020597342,
-0.004227677,
0.023705188,
-0.0012865475,
0.005718688,
-0.024019748,
0.0016058251,
0.021830415,
-0.012802563,
-0.028687807,
0.014243244,
0.02457337,
-0.018231856,
0.00003329905,
-0.027354077,
-0.01713719,
0.01910004,
-0.01421808,
0.013928685,
-0.010776801,
-0.0071593695,
-0.03943315,
0.022107227,
-0.022786675,
-0.0053884005,
-0.0029725854,
0.0069706338,
0.020005971,
-0.013865774,
-0.02191849,
0.007517967,
0.004435286,
0.010273506,
-0.018609328,
-0.0077004116,
0.011978418,
0.01209795,
0.009820541,
0.0057658716,
-0.034526028,
0.03653921,
0.00016081844,
-0.017011367,
0.010764219,
-0.01368962,
0.004891397,
0.008606342,
-0.003988612,
0.015035934,
-0.017602738,
0.0032100775,
0.0010333273,
0.03213538,
-0.015665052,
0.012016165,
-0.03246252,
-0.010021859,
-0.015954448,
-0.012475422,
0.013538632,
-0.02276151,
-0.014708792,
-0.008908319,
-0.016570983,
0.0028231696,
-0.0077759055,
0.0066875303,
-0.0037872938,
0.020282783,
-0.02318931,
0.033192296,
0.0049417266,
0.012173444,
0.024384636,
0.010298671,
-0.026347486,
-0.04101853,
0.0132869845,
-0.00034149343,
-0.035205476,
0.006567998,
0.022295963,
-0.0041993666,
-0.01124864,
0.0066497833,
0.021616515,
0.01730076,
0.014356486,
-0.009197714,
-0.026724957,
0.018798063,
-0.02647331,
0.0021279936,
0.025064085,
-0.0040515237,
0.001255878,
0.0066497833,
0.013400226,
0.021289373,
-0.0031959224,
-0.009348702,
-0.0069643427,
0.029467914,
-0.011116525,
0.006140197,
0.0042119487,
-0.00032458585,
-0.026976604,
0.007354396,
-0.006932887,
0.009021561,
-0.040792048,
-0.017112026,
-0.016143182,
0.02642298,
-0.0063320785,
-0.0042182403,
-0.021452943,
-0.018156363,
-0.020257618,
-0.0024283978,
-0.006838519,
0.029795056,
0.0047844467,
-0.02939242,
-0.00010006917,
-0.0034632978,
-0.0017001929,
0.005567699,
0.00522483,
0.019980807,
0.00019483017,
0.0066623655,
-0.008776204,
0.037973598,
0.010965536,
0.017816639,
-0.0401126,
0.0031393017,
0.005051822,
0.0012252084,
0.037319314,
-0.015149175,
-0.022509862,
0.0040295045,
0.028939454,
-0.011575782,
0.009046725,
0.0061496343,
0.011468831,
0.017061695,
-0.0061433427,
0.020635089,
-0.0054890597,
-0.013614126,
0.0036488879,
-0.022509862,
-0.001139491,
0.009317246,
-0.011324135,
-0.005246849,
-0.020496683,
0.006807063,
-0.0146836275,
-0.007920603,
-0.024976008,
-0.008203706,
0.00055716315,
-0.014570386,
-0.0045107803,
0.019276192,
-0.0023607675,
-0.0036488879,
-0.006775607,
0.0038879528,
-0.0036268686,
0.006712695,
0.017665649,
0.0057910364,
0.01496044,
-0.0035796848,
-0.037394807,
-0.0012668875,
0.030197691,
0.0018558998,
0.0115569085,
-0.016986202,
-0.013073084,
-0.026674628,
0.0063478067,
-0.003856497,
-0.006121324,
0.010990702,
0.007882856,
-0.0074298903,
0.0022129246,
0.012569789,
-0.00769412,
-0.008442772,
0.0003572214,
-0.009606641,
-0.006096159,
0.021666843,
-0.024812436,
-0.024183318,
-0.029216267,
0.0031330106,
0.17403936,
-0.018496087,
-0.018483505,
0.02695144,
-0.0010569192,
-0.005171355,
0.01284031,
-0.0020509264,
-0.024648866,
0.008367277,
0.013148578,
-0.0058508026,
-0.0069957986,
0.0008327957,
-0.0034035314,
0.012834019,
-0.036488876,
0.0028451888,
0.0064610476,
-0.023805847,
-0.00096333784,
-0.011714187,
-0.005300324,
-0.012274103,
0.024233647,
0.00822258,
0.0014579823,
-0.0071593695,
0.037898105,
0.03039901,
-0.014004179,
0.008625216,
-0.008713292,
0.017212683,
0.0114751225,
0.008725875,
0.007316649,
-0.010588066,
-0.0115569085,
-0.017539825,
-0.015677635,
-0.0019188117,
-0.018835811,
-0.011695314,
0.013324731,
-0.0014430408,
-0.0036960717,
-0.005190228,
0.013765114,
-0.0006822005,
-0.019666247,
-0.025756115,
0.012676739,
0.01581604,
0.01682263,
-0.0021311392,
0.0073669786,
0.00087997963,
-0.0006483853,
0.018294768,
0.0046082935,
0.0062691667,
-0.029266596,
0.041194685,
-0.01517434,
0.02795803,
-0.04212578,
0.013928685,
-0.0043000253,
-0.020245036,
-0.0011158991,
-0.016331919,
-0.023843594,
-0.0010812975,
-0.008008679,
-0.0027240834,
0.037646454,
0.010254633,
-0.013337314,
0.007643791,
-0.020760912,
-0.004488761,
0.006574289,
-0.01782922,
-0.013815444,
-0.03369559,
0.022182722,
-0.001684465,
-0.0016891834,
0.00063658936,
-0.007140496,
0.006945469,
-0.0047183894,
0.012494295,
0.010229468,
-0.034878332,
-0.012469131,
-0.006218837,
-0.00036469218,
-0.028184513,
-0.012532042,
0.081936404,
0.018546415,
0.02328997,
-0.03887953,
-0.013664455,
-0.00907189,
0.013437972,
0.023214476,
0.011814847,
-0.0056117377,
-0.03714316,
-0.00028880476,
-0.026750121,
-0.0032997269,
0.030726152,
0.025718367,
-0.02934209,
-0.014054509,
-0.020068882,
-0.0006192886,
-0.017816639,
0.045950823,
0.00939274,
-0.012003583,
0.0077696145,
0.009380158,
0.0009145811,
-0.014029345,
-0.04089271,
0.005385255,
-0.049851354,
-0.009329828,
-0.020773495,
0.0029946044,
-0.0034318417,
0.0080653,
0.0017898424,
0.04600115,
0.020622507,
-0.003359493,
0.003346911,
-0.001498875,
0.0014194488,
-0.006086722,
-0.010657269,
0.016432578,
-0.018609328,
-0.0075620054,
0.0037715659,
-0.022849586,
-0.010952954,
0.026171332,
-0.009122219,
0.03538163,
-0.020282783,
-0.006700113,
-0.049599707,
-0.016218677,
0.008644089,
-0.011833721,
0.018596746,
0.025567379,
-0.016432578,
0.0013974296,
0.01214828,
-0.15330361,
0.03193406,
0.012450256,
-0.031229446,
0.022094645,
-0.006498795,
0.0010608512,
-0.004079834,
-0.0018936469,
-0.009594059,
0.024812436,
-0.0026942003,
-0.004875669,
0.02053443,
0.032085046,
0.0042528417,
-0.009619223,
0.023692606,
0.014532639,
0.00025872502,
-0.020949649,
-0.040414575,
0.0120476205,
-0.021616515,
-0.0028310337,
0.014041927,
0.0110599045,
0.036690194,
-0.024699196,
0.0035419376,
-0.030122198,
0.012525751,
0.03198439,
0.009405322,
0.008606342,
-0.012922095,
0.0003039429,
-0.023466123,
-0.0047089527,
0.0198424,
0.036992174,
0.02843616,
0.016495489,
0.025768697,
-0.013727367,
0.012091659,
0.022371456,
0.010411913,
0.014784287,
0.016835213,
0.009260626,
0.00987087,
-0.0075934613,
0.0007112972,
-0.027630888,
-0.00028408636,
-0.012651575,
0.002278982,
0.0025416391,
-0.01029238,
-0.006914013,
-0.044742912,
0.031053293,
0.012267812,
0.0013195762,
-0.006275458,
0.019439764,
-0.0030496523,
-0.0067630247,
0.019779488,
-0.027656052,
0.0053758183,
-0.0027177923,
0.00068613247,
0.032160543,
-0.005322343,
-0.0074298903,
0.025315732,
-0.014872363,
-0.004372374,
-0.015690217,
-0.010544027,
-0.022308545,
-0.030700987,
-0.006275458,
-0.008254035,
0.022295963,
-0.0010223177,
-0.012557207,
-0.0028546255,
0.044239618,
-0.029090444,
0.025579961,
-0.016281588,
0.005677795,
0.0034632978,
0.02457337,
0.0017033386,
0.026221663,
0.0068573924,
-0.009902326,
0.0016435722,
-0.004186784,
0.014155168,
0.014520057,
-0.006718986,
-0.01448231,
-0.037042502,
0.028360665,
-0.0349035,
-0.019137787,
-0.011047322,
0.00732294,
0.018584162,
-0.0080653,
0.027630888,
0.03862788,
-0.012261521,
0.04192446,
-0.023101235,
0.051738713,
-0.00014715477,
0.0030417882,
0.02180525,
-0.020547012,
-0.01830735,
-0.12693097,
-0.035884924,
-0.0057910364,
-0.0020965377,
0.0000054433503,
0.02185558,
0.0005850803,
-0.012884349,
-0.000016538937,
0.01782922,
-0.019188117,
-0.009134802,
-0.0016199803,
-0.0064295917,
0.022031732,
-0.0011567918,
-0.0022317981,
-0.020836407,
-0.015639888,
0.033670425,
0.002634434,
-0.011846303,
0.0011339863,
-0.0005123384,
-0.004164765,
-0.005926297,
-0.0194146,
-0.0030716714,
-0.0035513744,
0.013878356,
0.0025841047,
0.003894244,
0.009833124,
-0.021050308,
-0.00037432555,
0.0048033204,
-0.023390628,
-0.023755517,
0.030499669,
-0.010833422,
-0.0016003203,
0.026121004,
0.02737924,
0.0018826374,
-0.019590752,
-0.0042780065,
-0.03135527,
0.007115331,
0.031707577,
-0.010286089,
-0.007838817,
-0.009833124,
-0.019452346,
-0.03331812,
0.029795056,
-0.011028449,
0.0079394765,
0.03613657,
0.010682434,
0.011663859,
0.01044966,
0.027656052,
-0.016810048,
0.0013911384,
0.0037117996,
-0.016294172,
-0.014733957,
-0.024372054,
0.01214828,
-0.010084771,
-0.01862191,
-0.00033775804,
-0.0067252778,
-0.013073084,
-0.019490093,
0.00021566972,
-0.0020839553,
-0.022912499,
-0.015904117,
-0.0132869845,
-0.010468533,
0.0022443805,
0.029518243,
-0.003777857,
0.031581752,
0.014280992,
0.017376255,
-0.0118903415,
-0.008090465,
0.011921797,
-0.01018543,
0.03349427,
0.009556311,
-0.027505064,
0.005970335,
0.012355889,
-0.015287582,
-0.025064085,
0.020521848,
0.015576976,
-0.010141391,
-0.0034129682,
-0.028587148,
0.011594655,
0.010430786,
0.007650082,
0.0049417266,
-0.0022066333,
0.0072222813,
-0.0035828303,
0.00040027668,
-0.014004179,
-0.0014328175,
0.012154571,
-0.0049794735,
-0.006920304,
-0.042780064,
-0.03178307,
0.01586637,
0.010657269,
0.026800452,
0.0056148833,
-0.029115608,
0.014671045,
-0.0092543345,
0.059388794,
0.0032242327,
-0.014318739,
0.0036709069,
0.03077648,
-0.020672837,
-0.0153379105,
0.019276192,
-0.023931671,
-0.025378643,
-0.0110599045,
-0.037218656,
-0.02264827,
-0.014079674,
0.023629693,
0.02340321,
0.024686612,
0.0061055957,
0.002271118,
0.0073795607,
-0.023529034,
0.0141048385,
-0.009367576,
-0.03973513,
0.018848393,
-0.0032053592,
-0.026271991,
0.0090907635,
0.014658463,
-0.006706404,
-0.0032493975,
-0.030625492,
0.00032458585,
0.0010765792,
-0.0041081444,
-0.039986778,
-0.011896633,
0.024925677,
0.016835213,
0.012060203,
-0.012613827,
0.009065598,
0.004737263,
-0.027731547,
-0.017904716,
-0.009833124,
0.009543729,
-0.024346888,
0.00870071,
0.01957817,
0.019011963,
0.006542833,
0.016105436,
-0.0013235082,
0.0036425965,
0.0055739908,
0.03671536,
0.032865155,
-0.0032037864,
-0.06291186,
0.017162355,
0.052242007,
-0.009122219,
-0.010789383,
0.045548186,
0.009411613,
-0.005347508,
-0.0032195144,
0.009141093,
-0.00854343,
0.015614723,
0.023113817,
0.03862788,
-0.0076060435,
0.0046774964,
0.003607995,
0.0025416391,
-0.016004777,
-0.013815444,
0.0018087159,
-0.031556588,
-0.01654582,
0.011657567,
-0.010273506,
-0.023466123,
0.008662962,
0.01077051,
0.020408606,
0.016432578,
0.008971231,
-0.0032871445,
-0.0075620054,
0.0006790549,
-0.032512847,
0.011852594,
-0.023227058,
-0.0030496523,
0.014947858,
0.026599133,
-0.0069706338,
0.007417308,
0.0046397494,
0.0013415953,
0.016055105,
-0.019326523,
0.025189908,
0.005885404,
0.013966433,
-0.01092779,
-0.03646371,
-0.011770808,
-0.012777398,
-0.04897059,
0.0014532639,
0.0030292058,
-0.0029033823,
0.055261776,
0.01018543,
-0.01491011,
-0.00072820473,
-0.0033500565,
0.030373845,
0.006561707,
0.018395428,
-0.019527841,
0.0035985583,
0.021968821,
-0.013437972,
-0.010808257,
-0.04240259,
-0.007140496,
0.022623103,
0.022396622,
-0.0063132048,
0.015274999,
0.0051021515,
0.021239042,
-0.024686612,
0.007624917,
-0.0056998143,
-0.018395428,
-0.027731547,
0.042478085,
0.020949649,
-0.005158772,
-0.039936446,
-0.0067630247,
-0.0024755816,
-0.033066474,
-0.0030103324,
0.029971208,
0.008209998,
-0.014180332,
-0.027706383,
0.013588961,
-0.0081848325,
-0.02127679,
0.0061244695,
-0.027781876,
-0.0045296536,
-0.034928665,
-0.0090907635,
0.013224073,
-0.0015295446,
-0.026498474
] |
The Global HIV Vaccine Enterprise convened a two-day workshop in May of 2007 to discuss humoral immune responses to HIV and approaches to design vaccines that induce viral neutralizing and other potentially protective antibody responses. The goals of this workshop were to identify key scientific issues, gaps, and opportunities that have emerged since the Enterprise Strategic Plan was first published in 2005 [1], and to make recommendations that Enterprise stakeholders can use to plan new activities. Most effective viral vaccines work, at least in part, by generating antibodies that inactivate or neutralize the invading virus, and the existing data strongly suggest that an optimally effective HIV-1 vaccine | [
-0.05222359,
-0.011893475,
-0.0021934959,
-0.011571676,
-0.001581911,
-0.0016007922,
-0.010087454,
-0.007946497,
-0.022223921,
-0.015183719,
0.007972766,
0.00395683,
-0.019137265,
-0.007847986,
-0.0023888745,
0.02255229,
0.038064376,
-0.01630017,
-0.00032015843,
0.0019258761,
-0.014789678,
-0.0043344526,
0.0059073335,
-0.009995511,
-0.019531306,
0.01761364,
0.023300966,
-0.029763242,
-0.03425531,
0.008005603,
0.012707828,
-0.0023576797,
-0.004830288,
0.0035660726,
0.0029273974,
-0.019308016,
0.009253399,
-0.0011033153,
0.040770125,
0.024167858,
0.015998071,
0.01803395,
-0.0015137747,
0.0001234457,
-0.012970521,
0.010547169,
0.006705267,
-0.00042728838,
-0.005237464,
0.027136302,
0.001582732,
0.01046836,
-0.021816745,
0.0077888803,
0.00030722897,
-0.014198616,
-0.026676586,
0.017955141,
0.0016812423,
-0.038090646,
-0.0077100717,
-0.0026729126,
-0.01630017,
0.0011287638,
-0.0080909785,
-0.00577927,
0.0015761646,
0.0048335716,
-0.00026577254,
0.02805573,
0.011551973,
0.017088251,
-0.0022443926,
0.037223753,
0.03436039,
-0.012136468,
-0.022565423,
-0.02431234,
-0.005434484,
-0.010724487,
0.018047085,
-0.0052670166,
-0.0045413245,
0.009995511,
0.015288797,
0.018375453,
0.018940244,
0.008800252,
0.012451701,
0.00066986994,
-0.010100588,
-0.0091614565,
0.00644914,
0.010704785,
-0.030682672,
0.015866723,
0.022933194,
0.01079016,
0.0062225666,
-0.013423668,
-0.016628537,
-0.021974362,
-0.0074211084,
-0.018690685,
-0.012418863,
0.0075196186,
0.002677838,
-0.0060025603,
0.0073488676,
-0.011171067,
-0.0065969056,
0.019452497,
-0.046181623,
-0.035516243,
0.018362317,
0.006422871,
0.0021245386,
0.012661856,
0.015551491,
-0.015722241,
0.01887457,
0.012175872,
0.034990855,
-0.0048040184,
0.03212749,
-0.009207428,
-0.043843646,
-0.029710703,
0.0055658314,
-0.0069810958,
0.010225368,
0.020424467,
-0.0033789028,
0.004879543,
-0.005152088,
0.020700295,
-0.01624763,
-0.0003454017,
-0.011348385,
-0.007040202,
0.023471719,
0.029185316,
-0.011946014,
0.010527466,
-0.003874738,
0.021751072,
0.02711003,
0.008255162,
0.0026909728,
0.011322116,
-0.017705582,
-0.027083762,
0.018139027,
0.007388272,
0.0041472833,
0.0063177934,
-0.02760915,
0.038011838,
-0.016654806,
0.0045577427,
0.008058142,
-0.015315066,
0.017061982,
0.010376417,
0.0045084874,
0.02071343,
0.01619509,
-0.0036284623,
0.0036547317,
-0.01582732,
-0.014172347,
0.03730256,
-0.019675788,
0.006823479,
-0.022841252,
0.027293917,
0.015984936,
0.013095301,
-0.01825724,
-0.025192365,
-0.0030915812,
0.022617962,
0.01607688,
0.004400126,
-0.028607387,
-0.008301133,
-0.0029339648,
-0.024903402,
0.014027865,
-0.00059886044,
0.010645678,
0.0030176984,
0.019991022,
-0.003176957,
-0.6476986,
-0.01014656,
0.031470753,
-0.0038550359,
0.0012707827,
0.004646402,
0.007092741,
-0.0022164816,
-0.022000631,
0.029316662,
-0.013765171,
0.01962325,
0.00053195556,
-0.033572305,
-0.018493665,
-0.02029312,
-0.005155372,
-0.017153924,
0.02805573,
-0.013988461,
-0.012648721,
0.017075116,
-0.006015695,
0.005312988,
0.010317311,
0.0005479635,
0.017416619,
-0.010573437,
-0.008517857,
0.015761646,
-0.004899245,
0.027136302,
-0.001369293,
0.0029273974,
0.045945197,
0.008662338,
-0.002707391,
0.02026685,
0.001309366,
0.024877131,
-0.018099623,
-0.0034872643,
0.027477803,
0.00561837,
-0.012037957,
0.031418215,
0.013581285,
0.00047202848,
0.0054509025,
-0.01580105,
0.016930634,
0.0013610838,
-0.016838692,
0.0053491085,
0.021173144,
-0.011716157,
0.0053819455,
-0.018638147,
0.00269754,
-0.003753242,
0.010987181,
0.0037466746,
-0.024614437,
-0.025139825,
-0.014382502,
0.007959631,
-0.004462516,
0.037276294,
-0.02758288,
-0.0074408106,
0.011913178,
0.01711452,
-0.01982027,
-0.0066757137,
0.012261247,
0.021015529,
-0.0033526334,
-0.028003192,
-0.03162837,
0.011486299,
0.0068628835,
-0.0029044116,
-0.018690685,
0.005890915,
0.0097065475,
-0.0073094633,
-0.023970837,
0.015393875,
0.0026023134,
0.02473265,
0.005102833,
0.011499435,
0.00820919,
-0.035332356,
-0.025481328,
0.019518172,
-0.0083865095,
-0.003135911,
-0.016733615,
-0.0036777174,
-0.022762444,
-0.014408772,
0.030997904,
-0.003589058,
0.020201176,
0.012543644,
-0.011952582,
0.03386127,
0.056164,
-0.029999666,
-0.017048847,
0.0067315362,
-0.01808649,
-0.0111185275,
0.00932564,
-0.02934293,
0.008570395,
-0.000004931928,
0.017245868,
-0.009982375,
0.011867207,
-0.013555015,
0.008340538,
-0.019321151,
-0.010304176,
0.012083929,
-0.0018913975,
-0.042477638,
-0.02133076,
-0.0103435805,
0.0052834353,
-0.0005992709,
0.0048861103,
0.014132943,
0.027766766,
0.009424151,
0.019636383,
0.012412297,
-0.042687792,
-0.011998553,
-0.0011977209,
-0.012839174,
-0.0010466718,
0.014369368,
-0.0014817589,
-0.012602749,
-0.00845875,
0.019110996,
0.00513567,
0.021882419,
0.019899078,
-0.0033509918,
-0.010783593,
0.021527782,
0.039088883,
-0.0014251155,
-0.0048828265,
-0.052722707,
-0.00034663308,
-0.009778788,
0.005963156,
0.012431999,
0.022959465,
0.009594902,
-0.012977089,
-0.006642877,
0.007749476,
0.01619509,
0.0007872614,
-0.04815183,
-0.0029175463,
-0.035778936,
-0.032258835,
0.042897947,
0.010908373,
0.0069022877,
-0.018546203,
-0.01865128,
-0.008274864,
-0.000107745625,
-0.012760366,
-0.0058350926,
-0.0017666179,
0.004695657,
0.03239018,
-0.03601536,
0.01138779,
0.013206946,
0.027372725,
0.00539508,
-0.0052505983,
0.0020949855,
-0.014540118,
0.009148322,
-0.008649203,
0.003398605,
-0.013633824,
-0.00001936856,
0.0010146559,
0.0100480495,
-0.0029684433,
-0.0041505666,
0.010901805,
0.0010401044,
0.0047055082,
-0.026466431,
0.009864164,
-0.021816745,
0.015998071,
0.00969998,
0.017928872,
-0.029789511,
-0.016221361,
0.011919745,
-0.005247315,
-0.012195574,
-0.0043443036,
0.0033197966,
-0.030183552,
0.014750274,
-0.0012223485,
-0.0034018885,
0.003874738,
-0.026335083,
-0.016759884,
0.015275662,
-0.0025530583,
0.036278054,
-0.0060386807,
-0.014211751,
0.006830047,
-0.0053885127,
0.0053523923,
0.0046989406,
0.012944252,
-0.0045478917,
-0.009332208,
-0.013377697,
0.021238819,
0.010133425,
0.0017304973,
-0.0143956365,
0.010428956,
0.014605792,
0.02076597,
0.0036580153,
0.021068066,
0.0175611,
-0.01235319,
0.01619509,
-0.040665045,
0.007473647,
-0.01081643,
-0.01689123,
0.0032886018,
-0.0020243863,
-0.008333971,
0.00969998,
0.025310576,
0.039535463,
0.024942804,
0.003369052,
0.009555498,
0.0051488043,
-0.0027878413,
0.00015525632,
-0.004015936,
-0.019715192,
-0.0077100717,
0.020503275,
0.0039404114,
-0.023012003,
0.021094337,
-0.0015367605,
0.010882103,
0.01669421,
0.0121430345,
-0.0026220155,
0.010231935,
0.023800086,
-0.023406044,
-0.013896518,
0.0029290393,
0.013095301,
0.007907093,
-0.006166744,
0.014789678,
-0.004652969,
-0.023524256,
-0.0011886908,
-0.013154407,
0.024207262,
0.006705267,
0.0046398346,
-0.005398364,
-0.02294633,
0.037959296,
-0.016155688,
-0.0076049943,
-0.015262527,
-0.0062192827,
-0.014868486,
-0.011052854,
-0.029211584,
0.0146451965,
0.008274864,
0.0048532737,
-0.03207495,
-0.0009563707,
-0.010849266,
0.020805374,
0.002334694,
0.017153924,
-0.009988943,
-0.0051586553,
0.023629334,
-0.02269677,
0.022342134,
0.012037957,
-0.015104911,
-0.008347105,
-0.022486616,
-0.0017699015,
-0.018454261,
0.07407974,
0.011794965,
0.0050798473,
0.018362317,
0.0065377993,
0.027398994,
-0.0012239903,
-0.047153592,
0.024863997,
-0.021251952,
-0.017968277,
-0.020857912,
0.007966199,
-0.01267499,
0.01235319,
0.01716706,
-0.006058383,
-0.00826173,
0.0150786415,
0.014763408,
0.00084144203,
-0.003457711,
0.020214312,
0.021015529,
0.025205499,
-0.0040750424,
0.014500715,
0.019991022,
-0.001267499,
-0.029369202,
0.025678348,
0.01146003,
0.00019825196,
0.016575998,
-0.019505037,
-0.03475443,
-0.0053655272,
0.013417101,
0.021370165,
0.00209006,
0.021593455,
0.02116001,
-0.0020522976,
0.020726565,
-0.0029684433,
0.00679721,
0.0021688682,
0.010212233,
-0.005598668,
-0.019885944,
0.009397881,
-0.022145113,
-0.008406212,
-0.019912213,
-0.013200379,
0.013673228,
0.0010277907,
-0.009667143,
0.006928557,
-0.032679148,
-0.027267648,
-0.015288797,
0.018125894,
0.0008775625,
-0.030630132,
-0.009601469,
-0.00533269,
0.011545406,
0.0051586553,
-0.013515611,
-0.009043245,
-0.027031222,
-0.009148322,
0.0051061166,
0.007276627,
0.012766933,
0.015617165,
-0.0064786933,
0.004288481,
-0.01203139,
-0.00625212,
-0.01146003,
-0.01324635,
-0.017679313,
0.021948092,
0.01714079,
-0.013200379,
-0.0021114037,
-0.007289761,
0.007578725,
0.0030587444,
-0.012872011,
0.025507597,
0.020227445,
-0.0054837395,
0.025954178,
0.03302065,
0.01830978,
-0.015551491,
-0.017193329,
-0.022539154,
-0.027950652,
0.024010241,
-0.016221361,
-0.0052079107,
-0.008721444,
-0.017272137,
-0.0003839849,
-0.018165298,
-0.025757156,
0.0360679,
-0.028922621,
0.0021721518,
0.0027008238,
0.021974362,
0.0213833,
0.034071427,
-0.011052854,
0.01493416,
-0.024772054,
-0.025704619,
-0.016667942,
0.004554459,
-0.0035660726,
-0.013633824,
0.0049846205,
0.013252918,
0.0009678636,
-0.008189488,
0.0048959614,
-0.0034215907,
0.029763242,
0.014185482,
-0.0035824908,
-0.026111795,
-0.01853307,
0.010317311,
0.002241109,
0.021567186,
-0.041032817,
0.009312506,
-0.010809862,
0.009949539,
-0.008885628,
0.03028863,
-0.02671599,
-0.01069165,
0.020568948,
-0.021777341,
0.0028978444,
0.014343098,
0.00025366398,
-0.014277425,
0.009266535,
-0.02582283,
-0.022013767,
-0.014251155,
-0.008603232,
0.009831327,
0.010310744,
0.020779103,
-0.01996475,
-0.021974362,
0.01830978,
0.022394672,
0.004350871,
-0.016575998,
-0.0025793277,
-0.029159045,
0.017994545,
0.010888671,
-0.0039042912,
-0.008911897,
-0.02671599,
0.021908687,
-0.004137432,
0.0040520565,
-0.028003192,
0.00028239615,
-0.03123433,
-0.008997273,
0.020082964,
-0.0025103705,
0.02626941,
-0.062416118,
0.0019521456,
0.01580105,
0.016759884,
0.014159212,
-0.0012404087,
0.006097787,
0.0031178505,
-0.0019833404,
-0.0097065475,
0.0016976607,
-0.000008215604,
-0.000012044422,
-0.008347105,
0.0048828265,
0.042477638,
0.010218801,
-0.016654806,
0.023038274,
0.0018946812,
-0.0057497174,
0.0024479807,
-0.021934958,
-0.003946979,
-0.009634307,
-0.024456821,
-0.015433279,
-0.010087454,
-0.022066304,
-0.012635587,
-0.016142553,
-0.009082649,
0.009384747,
-0.0037007031,
-0.025809696,
-0.019833405,
0.025612675,
-0.019807136,
0.023143351,
-0.020871047,
0.039404117,
0.041663285,
0.012826039,
-0.013660094,
-0.0121299,
0.0061503258,
0.02066089,
0.0024693245,
0.018992784,
-0.001794529,
-0.026335083,
0.018716956,
0.020779103,
0.015433279,
-0.033624846,
0.04184717,
0.016851828,
-0.0047514797,
-0.02249975,
-0.03283676,
-0.015617165,
0.035936553,
0.0047317776,
0.016825557,
-0.0032294956,
-0.028344695,
-0.020871047,
0.0038419012,
-0.001146824,
0.02383949,
0.015301932,
-0.037617795,
-0.018638147,
-0.025336847,
0.004350871,
0.014251155,
-0.00022328999,
0.026518969,
0.0028469474,
-0.00084636756,
0.014842217,
-0.0015884785,
0.0065476503,
0.03966681,
0.0014103389,
0.030104743,
-0.0025826113,
-0.014671465,
0.021146875,
-0.017508563,
0.021475242,
0.005812107,
-0.0031933752,
-0.017259002,
-0.0077035045,
0.0021754354,
0.031076713,
0.015512086,
-0.014356232,
-0.0054509025,
-0.0024003673,
0.00046094606,
-0.010015213,
-0.01630017,
0.00035833116,
-0.02802946,
-0.017061982,
-0.005700462,
-0.020082964,
0.026151197,
-0.0055822497,
0.012569913,
0.017429754,
0.015393875,
-0.0236162,
0.0013307098,
0.0027829157,
0.01401473,
-0.025166094,
-0.0037401072,
-0.030052206,
-0.00018183357,
0.0110725565,
-0.023379775,
-0.018270375,
-0.014185482,
-0.017889468,
0.019885944,
0.016063744,
-0.024220396,
0.012110198,
-0.006472126,
0.012116766,
-0.014618927,
-0.020818507,
0.038432147,
0.005703746,
-0.004281914,
0.025507597,
-0.03215376,
0.01046836,
-0.0014439967,
0.010928075,
-0.0169175,
-0.039588,
-0.029710703,
-0.020201176,
-0.0072569246,
0.012077361,
-0.01513118,
-0.0022657367,
-0.0029454576,
-0.0054016476,
-0.010159695,
0.007834852,
-0.019452497,
-0.008537558,
-0.0073160306,
0.007000798,
0.009168024,
-0.01711452,
0.0059106173,
-0.0022772294,
-0.042924218,
-0.021422705,
0.002942174,
-0.004130865,
0.049255144,
0.02716257,
-0.0044395304,
-0.010396119,
-0.020779103,
-0.05025338,
0.011972284,
0.009122053,
0.0019488619,
0.0149866985,
0.040349815,
0.0022624529,
0.021934958,
-0.013069032,
0.0016278825,
-0.01250424,
-0.018020816,
0.03212749,
-0.035437435,
0.020647757,
0.017508563,
-0.017889468,
0.007834852,
0.033966348,
0.0033132294,
-0.019977886,
0.009765653,
-0.014724004,
-0.0001819362,
0.0037007031,
0.028870082,
0.004584012,
0.023012003,
0.011604512,
-0.012661856,
-0.031864796,
0.009122053,
-0.012011688,
-0.014789678,
-0.020568948,
0.006245552,
0.008524423,
0.015525222,
-0.014027865,
-0.011873773,
0.016786152,
-0.014658331,
0.024010241,
0.008846224,
0.009010408,
-0.014947294,
-0.010277906,
-0.0046989406,
0.015118046,
-0.00027090329,
-0.016864961,
0.0026450013,
0.013417101,
0.0061207726,
0.0022805133,
0.0073291655,
-0.014001596,
-0.015748512,
-0.006803777,
-0.00017064855,
0.0048105856,
-0.02076597,
0.008629501,
0.0046332674,
-0.003134269,
0.0010647321,
-0.0015145957,
-0.0037992136,
-0.0106391115,
0.0106850825,
0.0057234475,
0.030603863,
0.0026745542,
-0.008268297,
-0.010960911,
-0.016562862,
0.012714394,
0.0025908207,
-0.015748512,
-0.008649203,
0.20826389,
-0.003359201,
0.011565108,
-0.021094337,
-0.041925978,
0.00545747,
0.02889635,
0.0029224718,
0.017153924,
-0.00021323372,
0.0047252104,
0.00046422973,
-0.025520733,
-0.0038024972,
-0.0143956365,
-0.02900143,
-0.034990855,
-0.0006817733,
-0.024982208,
-0.006908855,
0.009384747,
0.017666178,
0.009089216,
-0.0020539395,
0.021133741,
-0.006823479,
-0.02066089,
0.025376251,
0.0040717586,
0.002993071,
-0.01887457,
-0.02066089,
-0.0020342374,
0.008110681,
0.028449772,
0.0011739143,
-0.013344861,
-0.01982027,
-0.009772221,
0.0116636185,
-0.02001729,
0.031470753,
-0.03073521,
0.0038517523,
-0.00094898243,
0.01607688,
0.0016894514,
-0.017955141,
-0.01138779,
-0.0070205,
-0.024496226,
-0.010067752,
0.01193288,
0.01887457,
-0.001227274,
-0.00047449121,
0.015485818,
-0.011407492,
-0.004646402,
0.031155521,
-0.013436804,
-0.0014374293,
-0.0136206895,
0.03520101,
-0.003043968,
0.020844776,
-0.009969241,
-0.016208226,
0.008767416,
-0.010172829,
0.011742426,
-0.011295847,
-0.02475892,
0.01471087,
-0.03336215,
-0.015301932,
0.02805573,
0.03748645,
0.0031539712,
-0.00065016793,
0.007112443,
0.014132943,
-0.027661689,
0.009036677,
-0.006235701,
-0.0058482275,
0.0033789028,
0.02277558,
-0.025074152,
0.03123433,
-0.008412778,
0.0008775625,
-0.023038274,
0.0010934642,
0.00092928036,
0.009135188,
-0.0009612962,
-0.00024340251,
0.008123815,
-0.020332523,
-0.017416619,
0.06772254,
0.0058482275,
0.0027057494,
0.0032475558,
-0.00756559,
-0.014632061,
-0.0038583197,
-0.010612842,
-0.023025138,
0.0069745285,
-0.024469955,
0.014408772,
-0.0120510915,
-0.004797451,
0.019216074,
0.003763093,
-0.018559339,
0.033204533,
0.0038024972,
0.009667143,
-0.015984936,
0.0049353656,
0.013476208,
-0.003927277,
-0.0026729126,
-0.021527782,
0.027004953,
0.008248595,
-0.017692449,
0.023905164,
-0.0067085507,
-0.011545406,
-0.0056741927,
0.008596664,
-0.017259002,
-0.0056676255,
-0.02029312,
-0.008189488,
-0.0011098826,
-0.005785838,
-0.02889635,
0.014737139,
0.010711352,
-0.0025218634,
-0.02894889,
0.046024006,
0.015223123,
-0.0034412928,
0.008747714,
-0.014251155,
-0.009654008,
-0.005326123,
-0.054272603,
0.011716157,
0.0023708143,
-0.00501089,
-0.01689123,
-0.0021885703,
0.0058186743,
-0.033546038,
0.03170718,
0.025455058,
-0.007526186,
-0.019386824,
0.0037072706,
-0.1649719,
0.019702058,
0.004603714,
-0.012609317,
0.026453296,
-0.00019322382,
0.022512885,
0.0058088233,
-0.02071343,
0.027372725,
0.03344096,
-0.007112443,
-0.039798155,
-0.02847604,
-0.0009875656,
0.0032574069,
-0.025547002,
0.03028863,
0.033546038,
0.0042851977,
0.041242976,
-0.023051407,
-0.005772703,
-0.01155854,
0.005244031,
0.008189488,
-0.023800086,
0.007769178,
-0.019491902,
-0.0069219894,
-0.012103631,
-0.0040684748,
0.049754262,
-0.011959149,
0.022604827,
-0.00590405,
0.008182921,
0.0037893625,
-0.0056150863,
0.023773815,
0.047889136,
-0.0029191882,
0.0021458825,
-0.0018224403,
-0.015118046,
0.010606274,
0.018546203,
0.00046094606,
0.027004953,
-0.004308183,
0.021028662,
-0.0040586237,
0.008268297,
0.025638944,
0.020949855,
-0.019032188,
0.009181159,
0.011335251,
0.009640873,
-0.016090013,
-0.0032590488,
-0.021974362,
0.030341169,
-0.02448309,
-0.008879061,
-0.023327237,
-0.010376417,
-0.001684526,
-0.013193811,
0.021540916,
-0.028581118,
0.008629501,
-0.0069942307,
-0.03341469,
0.024286069,
0.018270375,
-0.021173144,
-0.010028347,
0.017009443,
-0.014763408,
-0.0065180976,
-0.0039929505,
-0.005703746,
-0.010133425,
0.000020741034,
-0.0048171533,
-0.004666104,
0.017206464,
0.008478452,
-0.0021820029,
0.005956589,
-0.039745618,
-0.0015958666,
-0.018244106,
0.012451701,
0.008478452,
0.023419179,
0.015498952,
-0.020897316,
0.02140957,
0.01848053,
0.0052407472,
-0.02716257,
0.006948259,
0.0016623611,
-0.0103895515,
-0.0017485577,
0.01778439,
0.043449603,
0.010291042,
-0.028633658,
0.01806022,
0.006816912,
0.027714228,
-0.011998553,
0.008176354,
-0.014526984,
0.007204386,
0.020674026,
-0.031418215,
0.053747214,
0.011033152,
-0.016759884,
0.012583047,
-0.028449772,
-0.020779103,
-0.12935057,
-0.022880657,
0.009194294,
-0.008379942,
0.008747714,
0.033624846,
0.010474928,
0.028975159,
-0.027372725,
0.017324677,
-0.037617795,
-0.011978851,
0.0019767731,
0.0011829444,
0.0383008,
0.009824759,
0.005982858,
0.0012428715,
-0.03249526,
0.026781663,
0.0049977554,
-0.014290559,
0.014224886,
-0.0024709664,
0.0020375212,
0.015735377,
-0.012819472,
0.018716956,
0.021094337,
0.0062192827,
-0.015840454,
-0.020385062,
0.024207262,
-0.019242343,
-0.02001729,
0.014500715,
-0.03170718,
-0.00034622263,
0.014435041,
-0.014211751,
0.012313786,
-0.00088495074,
0.008228892,
-0.007907093,
0.016142553,
-0.01136152,
-0.016536593,
-0.008064709,
0.004311467,
-0.012057659,
-0.023511123,
-0.014185482,
-0.054272603,
-0.012819472,
0.0062159994,
0.002626941,
0.007834852,
0.035857745,
-0.00025756337,
-0.008655771,
-0.0042589284,
0.0020145355,
-0.021370165,
-0.0023117082,
0.01959698,
-0.0012666781,
-0.026978685,
-0.030157283,
0.014067269,
-0.01136152,
-0.018441126,
-0.023997106,
-0.022407807,
0.010297609,
-0.005060145,
0.017364081,
0.003357559,
-0.008826522,
0.0088199545,
0.016103148,
-0.0036218949,
-0.02604612,
0.012366325,
0.016667942,
0.02802946,
0.010717919,
0.00756559,
0.016313303,
0.01381771,
-0.010304176,
-0.022749308,
0.022828117,
-0.017600505,
-0.029369202,
0.008491587,
0.012294084,
-0.012799771,
-0.030656401,
0.023471719,
0.03609417,
-0.0172196,
-0.0025464909,
-0.05211851,
0.020096099,
0.0024200694,
-0.0022755878,
-0.0016516892,
-0.013226648,
-0.0022985735,
-0.011144797,
0.009450421,
-0.0050273086,
-0.031864796,
-0.0020851344,
-0.017889468,
0.0012141393,
-0.02088418,
-0.015998071,
0.023432314,
0.019754596,
0.0048729754,
0.026427027,
0.00073184934,
0.001876621,
-0.009010408,
0.019005919,
0.004899245,
0.002282155,
-0.008957868,
0.009962674,
0.0029963546,
-0.0018142312,
0.0047252104,
-0.03207495,
-0.0025481328,
0.012543644,
0.0021081201,
0.0016270616,
0.028817544,
0.016904365,
0.020555813,
0.033257075,
-0.026479565,
-0.033598576,
-0.0003041505,
-0.0064852606,
-0.009949539,
-0.0044690836,
-0.02386576,
0.01203139,
0.0026926144,
-0.034885775,
0.04329199,
0.030183552,
-0.022906926,
-0.016786152,
-0.026427027,
0.020818507,
-0.0025317145,
0.009043245,
-0.00007372879,
-0.018244106,
0.022749308,
0.0063768993,
0.0016787795,
-0.0023888745,
-0.01079016,
-0.012714394,
-0.019872809,
0.000032554573,
0.018519934,
0.010888671,
-0.021672264,
0.010100588,
-0.0005812107,
0.0015646718,
-0.0078414185,
-0.00781515,
0.0041439994,
0.025665214,
-0.010284474,
0.012090496,
0.015393875,
-0.010908373,
-0.0057234475,
0.018506799,
0.028318424,
-0.0041637016,
0.006084652,
0.0156303,
0.0035989091,
-0.010251638,
0.0055658314,
0.00932564,
-0.03207495,
0.012464835,
-0.0057234475,
0.02607239,
0.0095752,
-0.0069416915,
0.017088251,
0.028423501,
0.0062258504,
0.01761364,
0.025047883,
-0.011703022,
-0.015892994,
0.0065673525,
-0.02986832,
-0.021133741,
-0.019321151,
-0.009634307,
0.0091614565,
0.0027106747,
0.0007211774,
-0.0061404747,
-0.025599541,
0.003032475,
0.004646402,
0.0072437897,
-0.031680908,
0.041216705,
0.0031424782,
0.010264772,
-0.010034915,
-0.024785189,
0.0074211084,
0.014185482,
0.009956107,
-0.014526984,
0.017022578,
0.0009251758,
-0.0021261803,
-0.017758122,
-0.0076049943,
-0.00937818,
-0.015695972,
-0.017206464,
0.023235293,
0.016549729,
0.0044099772,
0.055008147,
0.016050609,
-0.00845875,
-0.002981578,
-0.027372725,
0.009942972,
0.012044525,
0.0027221676,
-0.007847986,
-0.016063744,
0.02889635,
0.013344861,
0.016970038,
-0.04150567,
-0.026571508,
0.029500548,
0.002626941,
0.010547169,
-0.018493665,
0.0016484055,
0.03688225,
-0.0055329944,
0.020096099,
-0.0060222624,
-0.039509192,
-0.0017419902,
0.0058482275,
-0.0073488676,
0.008340538,
-0.03283676,
0.0010614484,
0.012077361,
-0.033178266,
-0.019058457,
-0.007972766,
-0.011131663,
-0.007637831,
-0.0014875054,
0.0012280949,
-0.008925032,
0.018506799,
0.017994545,
-0.021895554,
-0.040691316,
-0.014316829,
-0.024220396,
-0.049675453,
0.0044198283,
0.0084324805
] |
Data from certain leukemias as well as brain and breast cancer indicate that there is a small population of tumor cells with ‘stem cell’ characteristics and the capacity for self-renewal. The self-renewing cells have many of the properties of normal stem cells and have been termed ‘cancer stem cells’. These cancer stem cells make up as few as 1% of the cells in a tumor, making them difficult to detect and study. Like normal stem cells, cancer stem cells have a number of properties permitting them to survive traditional cancer chemotherapy and radiation therapy. These cells express high levels of ATP-binding cassette (ABC) drug transport | [
-0.002740934,
-0.0023084108,
-0.007872895,
-0.038878497,
-0.016989904,
0.012713268,
-0.003929968,
0.0055466658,
-0.020022426,
-0.009233643,
0.014203611,
0.024959994,
-0.010464796,
0.01319925,
-0.01266791,
0.014955262,
0.03343551,
0.004270155,
-0.03208772,
-0.0029369465,
-0.010659188,
0.0043608714,
-0.005154641,
0.010950777,
0.000220109,
0.011514515,
0.020126102,
-0.022057068,
0.01526629,
-0.026178189,
0.008967973,
0.0029142674,
-0.038956255,
0.012622552,
-0.009978814,
0.0017657317,
0.008378316,
-0.019594762,
0.01761196,
0.0025190026,
-0.0015348906,
0.008922615,
-0.0014020558,
-0.021111025,
-0.004600622,
-0.0039688465,
-0.0078793755,
0.0012254827,
0.003521744,
0.01809146,
0.020216819,
0.008514391,
-0.020748157,
0.0050736438,
-0.032191396,
-0.01163763,
-0.009129967,
0.010957257,
-0.0045455443,
-0.012447598,
0.00042604352,
-0.011760745,
-0.016238252,
0.011754266,
0.003260934,
0.017599,
0.00027255446,
0.023171585,
0.01139788,
0.0059354506,
0.024208345,
-0.0010966976,
0.0042312765,
-0.02065744,
0.002509283,
-0.018558003,
-0.010199126,
0.010834142,
-0.003800373,
0.006340435,
0.007898815,
-0.027888842,
-0.013814826,
0.008870777,
0.0060909647,
0.022614326,
-0.004114641,
-0.006282117,
0.013439001,
0.007283238,
0.005588784,
0.011682988,
0.0075748274,
0.017676756,
0.02353445,
0.030454822,
-0.011261805,
0.029262548,
-0.007989531,
-0.05463725,
-0.0027214948,
0.022057068,
-0.001914766,
-0.02222554,
-0.029884605,
0.011242365,
0.028277626,
0.0054753884,
0.021538688,
0.014294327,
-0.011099811,
0.024830401,
0.005404111,
-0.02794068,
0.035327595,
0.019296695,
-0.0053879116,
-0.011235885,
-0.026333703,
-0.0018143299,
0.015486602,
0.013043736,
0.022368096,
-0.023845479,
0.008345918,
0.031102797,
-0.014968221,
-0.0015324608,
-0.001971464,
0.0081061665,
0.0059354506,
0.0007034578,
0.004163239,
0.021435011,
-0.025076631,
-0.016095698,
-0.007911774,
0.0075100297,
-0.022173703,
-0.02923663,
0.007011089,
0.027629651,
0.00046168215,
0.017223174,
-0.00284461,
-0.004266915,
0.024117628,
-0.0092401225,
0.002818691,
0.0020314015,
0.007607226,
-0.008209842,
0.024947036,
-0.008397755,
-0.025011834,
-0.0025303422,
0.012583674,
0.018311772,
-0.029029278,
-0.01138492,
0.018830152,
0.0007702802,
0.021681242,
-0.004759376,
0.009246603,
0.02480448,
-0.008229282,
0.0150071,
-0.010425917,
-0.009227163,
0.010620309,
0.022886476,
-0.0023213702,
0.0018710276,
-0.038075007,
0.013464919,
-0.029055197,
0.018259933,
-0.03594965,
-0.0263985,
0.012765107,
0.031932205,
0.0025740806,
0.005851214,
-0.004302554,
0.0007557008,
0.039993014,
-0.013568595,
0.009129967,
-0.014022178,
-0.0014871025,
0.001602928,
0.0034861052,
-0.0047982545,
-0.6506705,
-0.03027339,
0.011857942,
-0.010523113,
0.027577814,
0.030143796,
0.01654928,
-0.024104668,
-0.048287094,
-0.011462677,
0.0004633021,
0.003257694,
0.001447414,
-0.0031459185,
-0.006628784,
-0.03239875,
-0.019957628,
-0.0016175074,
0.029418062,
-0.005154641,
-0.004626541,
0.0096548265,
-0.044813946,
0.02248473,
-0.0048468527,
0.016873268,
0.021901553,
-0.011151649,
-0.004603862,
0.02900336,
-0.030584417,
0.019724358,
0.0017511523,
0.019478127,
0.045902546,
0.024454575,
-0.0019568843,
0.0137759475,
0.0012044235,
0.03675314,
0.023340058,
-0.0061460426,
0.015123735,
0.00465894,
-0.03283937,
-0.0009509032,
-0.005229158,
0.01656224,
-0.016847348,
-0.011359001,
0.009777942,
0.010393518,
-0.031698935,
-0.003207476,
0.038878497,
0.014955262,
0.024000993,
-0.017262053,
0.012311524,
-0.00906517,
-0.006411712,
0.022018189,
-0.011462677,
-0.0043576313,
-0.0069203726,
0.02713719,
-0.0110544525,
0.0015664794,
0.014605355,
-0.016173454,
0.0025999995,
0.024415696,
-0.017922986,
0.0044353884,
0.013147412,
0.029132953,
0.0028397501,
-0.016341928,
0.0008909656,
-0.014773829,
0.004989407,
-0.013620433,
-0.018907908,
-0.00037177562,
0.021668283,
0.0019520245,
0.0034342671,
-0.00077271013,
-0.008754142,
0.017663797,
0.0043057934,
0.015020059,
0.009914016,
-0.058317747,
-0.0016701554,
0.017871149,
-0.026074512,
0.00077918987,
0.007296198,
-0.021823796,
-0.016704794,
-0.020061305,
0.034005724,
0.005919251,
0.007166603,
-0.007633145,
-0.010114889,
-0.01476087,
0.023715883,
-0.026281863,
0.003236635,
0.013153891,
0.0023991272,
0.005556385,
-0.00056535815,
-0.0062302793,
0.0051060426,
0.01783227,
-0.0065056686,
-0.035897814,
0.0003183177,
0.008099687,
0.007885856,
0.012998378,
0.016497442,
-0.00095576304,
0.01112573,
-0.0060423664,
0.0034504666,
-0.031698935,
-0.012551275,
-0.028692331,
0.009648347,
-0.025452456,
0.028277626,
-0.019504046,
0.001474953,
-0.010199126,
0.012538316,
-0.022743922,
-0.027759247,
-0.017145418,
0.0027328343,
-0.017534202,
-0.016445605,
0.009661307,
-0.032165475,
-0.018350651,
-0.023871398,
-0.011255325,
-0.007011089,
0.0016409965,
-0.013685231,
0.018441368,
0.029262548,
-0.012369842,
0.0030471021,
-0.017897068,
0.017145418,
-0.00568922,
-0.015810588,
0.013918502,
0.00959003,
0.0044645476,
0.0028640493,
-0.00310056,
-0.004347912,
0.013568595,
-0.008728223,
-0.045487843,
-0.013931462,
-0.019957628,
-0.013788907,
0.0017738314,
0.0044094697,
0.0017948906,
-0.022121865,
0.0027344543,
0.010471275,
-0.01683439,
-0.013529717,
-0.023741802,
0.0012036135,
-0.013251088,
0.017961865,
0.021862675,
0.037867658,
0.0049084104,
-0.019853953,
0.0062076002,
-0.01395738,
0.02354741,
-0.012486477,
0.015706914,
0.019568844,
-0.01318629,
-0.00802193,
0.018311772,
0.013374203,
0.018441368,
0.0037064168,
0.00048557622,
0.0005276946,
-0.017158376,
0.018596882,
-0.03623476,
-0.014592396,
-0.015460682,
0.024947036,
-0.0042831143,
-0.0023165105,
0.009803861,
-0.017650837,
0.009453954,
0.0042863544,
0.015084857,
0.0066547026,
-0.0044645476,
0.017417567,
-0.019504046,
-0.009259562,
0.013581555,
-0.0035347033,
-0.010911898,
0.00958355,
0.008456073,
0.02225146,
0.0063598743,
-0.017871149,
-0.005818815,
0.013024297,
0.016160496,
0.033461425,
0.022199621,
0.0150071,
0.01424249,
0.028122112,
-0.01860984,
0.02558205,
-0.004807974,
-0.006606105,
0.02485632,
-0.021759,
0.005507787,
0.004474267,
-0.008527351,
0.025193267,
0.004315513,
0.010445356,
0.012052334,
-0.018959748,
0.0027247346,
-0.014657194,
0.01736573,
-0.014462801,
-0.0098233,
0.0027992518,
0.0201909,
0.015395884,
-0.0030552018,
0.023301179,
-0.012583674,
0.0012570714,
0.0026680368,
0.0047658556,
-0.007710902,
0.024597129,
-0.005579064,
0.0029644854,
0.022432894,
-0.029055197,
-0.0053425534,
0.020994388,
-0.022394015,
0.017339809,
0.015810588,
-0.001343738,
0.004522865,
0.0013121492,
0.017599,
-0.007827537,
-0.013646352,
0.02302903,
0.04346616,
-0.007373955,
-0.019970588,
-0.021111025,
0.002872149,
0.0067324596,
0.0065024286,
0.007108285,
0.010238004,
-0.0020378812,
0.019529965,
-0.011566353,
-0.019568844,
0.0027992518,
-0.012914141,
0.008695824,
-0.0026599371,
0.0060358867,
-0.027551895,
-0.0058576935,
0.020009467,
0.018208096,
0.012473518,
-0.0036318996,
-0.00904573,
-0.006965731,
-0.018195137,
-0.02403987,
-0.042325724,
0.004088722,
0.0028689092,
0.0028818685,
-0.002974205,
0.050775316,
0.011151649,
0.012765107,
-0.0035411832,
-0.0029418063,
-0.014812707,
0.0036902174,
-0.0030892205,
0.025491334,
0.006084485,
-0.013205729,
0.017093578,
0.009026291,
-0.01784523,
0.0046200613,
-0.0035282236,
0.01498118,
-0.025776444,
0.0073869145,
-0.0060002482,
0.020877752,
0.0011177568,
0.0104129575,
0.029651335,
-0.026592892,
-0.0034213078,
-0.0028284106,
-0.0055952636,
0.00069697807,
-0.008481992,
0.042273887,
0.048442606,
0.012551275,
-0.004947289,
-0.0011485356,
0.0165104,
-0.005196759,
0.007788659,
-0.02122766,
0.0094280355,
0.008294079,
0.0132834865,
0.0035541425,
-0.027992519,
0.007697942,
0.026450338,
-0.009862179,
0.003699937,
0.022743922,
0.022938313,
0.015447723,
0.00415028,
-0.014164733,
-0.005663301,
0.02172012,
-0.006356634,
-0.002123738,
-0.047328092,
0.024143547,
-0.023340058,
-0.009972335,
-0.010503674,
0.006259438,
0.0025627408,
-0.008112647,
-0.0064797495,
-0.006265918,
0.009214204,
-0.0051708403,
-0.015318128,
0.013607474,
0.010393518,
-0.006881494,
-0.0011347661,
0.0012125231,
0.006278877,
-0.02921071,
-0.0141906515,
0.015395884,
-0.027214948,
-0.031621177,
0.015305168,
0.02376772,
0.0106786275,
0.0132834865,
-0.01736573,
-0.054170705,
0.021655323,
0.011145169,
-0.010516633,
-0.016769592,
-0.03618292,
0.001343738,
0.009641867,
0.0013315885,
-0.01660112,
-0.009602989,
0.013477879,
-0.010361119,
-0.014281368,
0.005637382,
0.00097601226,
-0.0008439874,
0.013983299,
0.03309856,
0.0021285978,
-0.01991875,
-0.0006487849,
-0.006103924,
-0.021668283,
-0.015927223,
0.018000744,
-0.016899187,
-0.030169714,
-0.011773705,
0.012130091,
-0.0072573195,
-0.018000744,
0.023664046,
-0.026981678,
0.009888098,
0.00069495314,
0.0035087843,
-0.006029407,
0.00057143293,
0.013931462,
0.014255449,
0.008209842,
0.0012327724,
-0.029884605,
0.014410963,
-0.004172959,
-0.012395761,
-0.0029806849,
0.0078404965,
-0.0074841105,
-0.023158625,
-0.028510898,
0.008546789,
0.02871825,
-0.022743922,
-0.030843608,
-0.008404235,
-0.009259562,
0.013264047,
0.029262548,
0.020398252,
-0.010212085,
-0.007885856,
0.03076585,
-0.0026955758,
-0.0121884085,
0.018389529,
-0.028044356,
-0.0051028025,
0.015149655,
0.016989904,
-0.01422953,
-0.0050930833,
0.023106787,
0.0049829273,
-0.023949154,
-0.001189844,
-0.008378316,
0.021810837,
-0.015369966,
0.050593883,
0.022394015,
0.030221552,
0.009888098,
0.025530213,
0.019996507,
0.007633145,
0.007522989,
0.008462553,
0.01552548,
-0.006486229,
0.008469033,
-0.012940059,
-0.0035055445,
0.015823549,
-0.012635511,
0.012810465,
0.04084834,
-0.001113707,
-0.00017880059,
-0.005229158,
-0.029132953,
-0.05536298,
0.006256198,
-0.011566353,
0.009726104,
-0.025283983,
0.008449594,
0.0087865405,
0.0021431772,
-0.015979063,
0.0008196883,
0.018856071,
0.004519625,
0.0073674754,
-0.0015138314,
0.016380807,
-0.026852082,
-0.005511027,
-0.01268087,
-0.014436882,
0.02197931,
-0.0052939556,
-0.001964984,
0.024065789,
-0.040070772,
0.01809146,
-0.011857942,
-0.033798374,
-0.032243233,
-0.010114889,
-0.02690392,
-0.009136447,
0.008345918,
-0.0300142,
-0.010970216,
-0.01889495,
0.0110544525,
-0.0046686595,
0.013503798,
-0.015888346,
-0.01756012,
0.039656065,
-0.010276883,
0.01942629,
-0.020268656,
0.017948907,
0.008838378,
-0.0019423049,
-0.013983299,
-0.0042215567,
-0.017573081,
0.007989531,
0.029936442,
0.025296941,
-0.011592272,
-0.019452209,
0.01164411,
0.011209967,
0.0045909025,
-0.0387489,
0.0105619915,
-0.004467787,
0.014074016,
-0.011488596,
-0.016406726,
-0.029832767,
0.011890341,
0.009266042,
0.017806351,
-0.004315513,
-0.02225146,
-0.02098143,
0.030999122,
0.0005098753,
-0.00012493767,
0.0016118377,
-0.004344672,
-0.0016474763,
-0.009661307,
-0.026592892,
-0.012732708,
-0.010024172,
0.025685728,
-0.01679551,
-0.0015883486,
0.039656065,
-0.021694202,
-0.025076631,
0.015395884,
-0.009790901,
0.03799725,
-0.026022675,
0.00905869,
0.012253206,
0.005744298,
-0.0022306538,
0.0051902793,
-0.015473641,
0.020307535,
-0.04424373,
-0.023975072,
0.029806849,
0.03232099,
0.0058803726,
-0.013115013,
-0.03473146,
-0.008903176,
-0.016873268,
-0.02170716,
-0.003414828,
-0.038463794,
-0.01631601,
0.0066676624,
0.024661927,
0.017689716,
-0.009713145,
0.0000988668,
-0.014294327,
0.03027339,
-0.0047561363,
0.00903925,
0.0015170714,
0.021098064,
-0.010892459,
0.0068426155,
0.017093578,
-0.028044356,
-0.0059613697,
-0.019555883,
-0.030066038,
-0.02357333,
-0.014618315,
0.018246975,
-0.0075424286,
-0.00413732,
-0.0075424286,
0.029158873,
0.01863576,
-0.0101861665,
-0.035379432,
0.010063051,
-0.02407875,
-0.0034083482,
0.0062173195,
-0.018389529,
-0.011514515,
-0.019840993,
-0.016575199,
0.00803489,
-0.0026259185,
-0.0015648595,
-0.026165228,
0.0066676624,
-0.0013923362,
0.018415447,
0.0024218063,
-0.015227411,
-0.007263799,
0.010950777,
0.012577194,
-0.006700061,
-0.0062756375,
0.005219438,
0.021940432,
0.017624918,
-0.029366225,
-0.007011089,
-0.022666164,
-0.03286529,
-0.019581802,
0.016147535,
-0.019737316,
0.03592373,
0.006184921,
0.0077756993,
-0.026437378,
-0.00024744542,
-0.030558499,
0.0034375072,
0.021499809,
0.031102797,
-0.013581555,
0.024895197,
-0.012739187,
-0.0046135816,
-0.009745543,
0.023197504,
-0.0013251088,
-0.0067842975,
0.027059434,
0.0050930833,
-0.00077595003,
-0.0045390646,
-0.02848498,
-0.020100184,
0.01660112,
-0.013555636,
0.017339809,
0.0051870393,
-0.018532084,
0.025595011,
0.0034504666,
0.022860557,
0.008579188,
0.037012327,
0.0015972583,
-0.016575199,
-0.004840373,
0.0008974453,
0.008209842,
0.004814454,
0.003281993,
-0.018428408,
0.014851586,
-0.0066093444,
-0.0031313389,
-0.015849467,
0.0018191896,
0.006495949,
0.021447971,
0.0024866038,
0.0026340182,
0.030869527,
0.0034439869,
0.003826292,
-0.003204236,
-0.03343551,
-0.010723986,
-0.0075618676,
0.00028348903,
-0.0045390646,
-0.012194889,
0.0041761985,
-0.00517732,
0.0014757629,
0.01474791,
-0.0045714634,
-0.017650837,
-0.009434516,
0.040174447,
-0.013568595,
-0.026878001,
-0.014074016,
0.009628908,
-0.0061622416,
-0.020113142,
-0.010205605,
0.00698517,
-0.02222554,
0.0010853581,
-0.009512273,
-0.005556385,
-0.004237756,
0.0021042987,
-0.00932436,
-0.011520995,
-0.008287599,
0.19885056,
-0.022912394,
-0.013244608,
0.028173951,
0.0025805603,
-0.000647165,
0.017378688,
0.0037906535,
-0.009926977,
0.009855699,
0.017599,
-0.00079538923,
-0.028148033,
-0.0039785663,
0.01784523,
0.00028409652,
-0.026437378,
-0.024195384,
-0.017728595,
-0.021020308,
-0.011540434,
-0.0137370685,
0.019244855,
-0.004869532,
0.015719872,
-0.005822055,
-0.0055175065,
-0.0072573195,
0.02791476,
-0.035146162,
-0.031932205,
0.0029191272,
-0.013672272,
0.0022792518,
0.006356634,
-0.008319998,
0.0030325227,
0.0011712147,
0.015642116,
-0.018467287,
-0.0023489092,
0.01989283,
-0.0046718996,
0.0004940809,
-0.0027052953,
0.034005724,
-0.014307287,
0.0049958867,
0.020216819,
-0.018674638,
-0.04605806,
0.012998378,
0.0110933315,
0.010898938,
-0.0067130206,
0.01295302,
0.018013705,
0.016173454,
-0.016108658,
0.034679618,
-0.013568595,
0.006803737,
-0.028847845,
0.023508532,
0.0017916508,
0.009149406,
-0.014410963,
0.03053258,
0.025011834,
-0.0064700297,
-0.024013951,
-0.0025983795,
-0.01395738,
0.016134577,
-0.00750355,
-0.029340306,
0.022627285,
-0.0032900928,
0.0075100297,
-0.0015818689,
0.010918378,
0.007458192,
-0.030584417,
-0.0022922114,
0.009434516,
-0.026955757,
0.008190404,
0.025802363,
-0.00750355,
-0.03493881,
0.0045941425,
-0.01918006,
-0.003155638,
0.0048954505,
0.012784546,
0.0008176634,
0.0036157002,
0.008410715,
-0.004519625,
-0.027007597,
-0.039681986,
0.04945345,
0.02921071,
0.0320618,
0.00013546726,
-0.0016231772,
-0.016432645,
0.004292834,
-0.010762864,
-0.0025514013,
0.015668035,
-0.017754514,
0.017910028,
-0.003699937,
-0.006363114,
0.020048345,
-0.008242241,
-0.03361694,
0.022355136,
-0.0071536433,
-0.0082552,
-0.0424294,
-0.0070240484,
0.03133607,
-0.006593145,
0.024739685,
-0.032709777,
-0.010393518,
-0.0008103737,
-0.031724855,
-0.027837005,
-0.008319998,
-0.008955014,
0.016432645,
0.006155762,
-0.01498118,
-0.008125606,
0.0030973202,
-0.026800243,
0.009726104,
-0.0150589375,
-0.0063793133,
0.002925607,
0.022679124,
-0.0010659188,
-0.026955757,
0.0063533946,
0.009888098,
-0.0121884085,
-0.021046227,
0.0052680364,
-0.027603732,
-0.0032674137,
0.004882491,
0.01371115,
-0.003985046,
-0.01969844,
-0.014022178,
0.0018289093,
0.03024747,
-0.028251708,
0.01240872,
0.009544671,
-0.0053976313,
-0.0055239866,
-0.022575447,
-0.16173455,
0.0059613697,
0.017689716,
-0.006058566,
0.013918502,
0.018467287,
-0.014553517,
-0.007192522,
-0.0013874763,
0.02302903,
0.034264915,
-0.0048274132,
-0.035483107,
-0.009123487,
0.01736573,
-0.027629651,
0.013762988,
0.051293697,
0.027551895,
0.014657194,
0.015020059,
-0.012888222,
0.026696568,
-0.009648347,
-0.004859812,
-0.009071649,
-0.0032917128,
0.007950652,
-0.0141906515,
-0.0146442335,
0.00931788,
0.0012084732,
0.010497194,
-0.013516758,
-0.006751899,
0.009337319,
-0.008715263,
0.000105700914,
0.0033467906,
0.015862428,
0.0061719613,
0.018843113,
0.007684983,
0.0067389393,
0.016989904,
0.049764477,
0.0018694077,
-0.015382925,
0.0047885347,
-0.0073545156,
0.039681986,
-0.0137759475,
-0.0007783799,
0.004717258,
0.019218937,
0.0044710273,
0.0009841119,
0.009162365,
0.003981806,
0.0021869154,
0.0071536433,
-0.01888199,
0.012557754,
-0.00031204044,
-0.0020330213,
-0.024661927,
-0.0026761366,
-0.0001087383,
-0.028588654,
0.013646352,
-0.030973203,
0.015382925,
0.020229777,
-0.008430154,
0.01706766,
0.013127972,
0.012091213,
-0.0033435507,
-0.010536073,
0.015395884,
-0.008967973,
0.03880074,
-0.013335325,
-0.018065542,
-0.013400122,
-0.011501555,
0.021590525,
0.009713145,
-0.01942629,
-0.024947036,
0.023612207,
-0.017741553,
-0.007296198,
0.0013834265,
0.012032894,
0.042636752,
0.005899812,
-0.021668283,
0.017624918,
-0.011391399,
0.022419933,
-0.012214328,
-0.02768149,
0.013788907,
0.034083482,
0.0035735818,
-0.013400122,
-0.01680847,
0.023456693,
0.00013182241,
-0.018946787,
-0.002300311,
0.019866912,
0.01863576,
0.0028899682,
0.025698686,
-0.0066871014,
0.005384672,
0.0048533324,
-0.023612207,
0.05194167,
-0.005025046,
0.0020735199,
0.03278753,
0.019063422,
-0.010646229,
-0.1286619,
-0.021007348,
0.0065477868,
0.007270279,
-0.016899187,
0.018545043,
-0.018506164,
-0.0045649833,
-0.011825543,
0.02455825,
-0.014670153,
-0.016160496,
-0.011812584,
-0.013879623,
0.0035833016,
0.0050801234,
0.0027555134,
0.008605108,
-0.031880368,
0.009350278,
0.0108276615,
-0.0019730837,
-0.017910028,
-0.025815323,
0.023988033,
0.021875635,
-0.045384165,
0.025141427,
0.026489217,
0.0146442335,
-0.006126603,
-0.011300683,
0.0019228656,
-0.009615948,
0.0035800617,
0.0103352005,
-0.018687598,
-0.031854447,
0.016186414,
-0.035042487,
0.0037614945,
0.02996236,
0.01498118,
0.008060808,
0.006836136,
-0.029158873,
-0.035301674,
0.0044062296,
0.009499312,
-0.018182177,
-0.02432498,
-0.009628908,
-0.0040660426,
-0.0043381923,
0.004169719,
-0.02794068,
0.013056695,
0.010587911,
0.0018515884,
-0.03156934,
0.0071342043,
-0.0069916495,
-0.009395637,
0.008760622,
0.00724436,
-0.0090133315,
-0.022925355,
-0.010989655,
0.03747887,
-0.020203859,
0.0047237375,
-0.015499561,
-0.018583922,
0.0034601863,
-0.011151649,
0.009991773,
0.007030528,
-0.0054203104,
0.0068944534,
-0.017987784,
-0.014838627,
-0.0043381923,
-0.019633641,
-0.014255449,
0.030402984,
-0.0006338005,
0.016328968,
-0.012920621,
0.02043713,
-0.0031102798,
0.0076720235,
0.03278753,
-0.015668035,
-0.02952174,
0.0019018064,
0.00984922,
0.0008642366,
0.0045909025,
0.014955262,
0.026528094,
-0.009110528,
-0.009810341,
-0.04504722,
0.015331088,
-0.016523361,
-0.0064279116,
0.008443113,
-0.010387039,
0.011929219,
-0.009641867,
-0.0018289093,
0.018869031,
0.022562487,
0.02227738,
-0.006100684,
-0.0038522112,
-0.031932205,
-0.012259686,
0.002893208,
-0.016212333,
-0.00080510887,
0.03159526,
-0.011365481,
-0.009797381,
0.018039623,
0.0051708403,
0.0129271,
0.01476087,
0.011333082,
0.052174944,
-0.007652584,
-0.010743424,
0.0033727097,
-0.034213077,
-0.01395738,
-0.007315637,
-0.014721991,
-0.007633145,
0.00064676,
0.025387658,
0.0011890341,
0.016173454,
-0.01345196,
-0.02457121,
0.022692082,
0.009732584,
-0.020320494,
0.0026809964,
-0.020579685,
0.01736573,
0.006648223,
0.016847348,
0.049012825,
0.020229777,
0.0151755735,
-0.04476211,
-0.014942302,
-0.019257816,
-0.006181681,
-0.013853705,
-0.036053326,
-0.0029013078,
0.029936442,
0.03729744,
0.015149655,
0.0058155754,
-0.046187654,
-0.014864545,
-0.022394015,
-0.0081061665,
-0.00020320089,
-0.025711646,
-0.012635511,
0.011067412,
0.007380435,
-0.004033644,
0.021149902,
0.001500872,
-0.029806849,
0.015123735,
-0.01321221,
0.024830401,
0.0059386906,
0.00012888627,
-0.0034051083,
0.006444111,
0.033409588,
0.0017705916,
-0.007898815,
0.032761615,
0.009596509,
-0.023495572,
-0.011799624,
0.011631151,
0.0027587533,
-0.00045074758,
0.016199375,
0.022692082,
-0.026502175,
0.014048097,
0.003231775,
0.050231017,
0.0004552024,
-0.0077756993,
0.0047464166,
-0.018246975,
-0.012512396,
0.00620112,
-0.028303545,
-0.0077692196,
-0.03102504,
-0.00097115245,
0.023689965,
0.00672598,
0.005096323,
-0.011579312,
-0.014436882,
-0.005481868,
-0.015214452,
-0.0019001865,
-0.0014376944,
0.022018189,
0.01552548,
0.016782552,
0.022199621,
0.0025044233,
0.011197007,
0.017871149,
0.021123983,
-0.011041493,
0.0131344525,
-0.014385044,
0.02485632,
0.009142927,
-0.040640987,
-0.010458316,
-0.017275013,
-0.021590525,
0.03359102,
0.026878001,
-0.033072643,
0.06982578,
0.006965731,
-0.019685479,
0.01989283,
-0.020113142,
0.033565104,
0.014009219,
-0.013685231,
-0.02560797,
-0.014877505,
0.033072643,
-0.03359102,
0.026644731,
-0.0424294,
-0.012991898,
0.022355136,
0.0026259185,
0.006751899,
-0.0007961992,
-0.0055401856,
0.0015551399,
-0.0029434261,
0.008955014,
0.0021107784,
-0.021331334,
-0.010179686,
0.022044107,
-0.017482365,
0.01526629,
-0.013879623,
0.016108658,
-0.01574579,
-0.054222543,
-0.024208345,
0.029262548,
-0.01111277,
-0.012194889,
-0.058836125,
0.016341928,
0.030636257,
-0.0040271645,
0.02739638,
-0.012136571,
-0.016406726,
-0.012194889,
-0.022355136,
-0.010626789,
-0.036804978,
0.020527847
] |
Alzheimer's disease (AD) is hypothesized to be caused by an overproduction or reduced clearance of amyloid-β (Aβ) peptide. Autosomal dominant AD (ADAD) caused by mutations in the presenilin (PSEN) gene have been postulated to result from increased production of Aβ42 compared to Aβ40 in the central nervous system (CNS). This has been demonstrated in rodent models of ADAD but not in human mutation carriers. We used compartmental modeling of stable isotope labeling kinetic (SILK) studies in human carriers of PSEN mutations and related noncarriers to | [
-0.012407881,
0.0104013905,
0.0021262332,
-0.013928931,
-0.03790326,
0.03161194,
-0.01963772,
0.017294658,
-0.03404562,
-0.001478169,
-0.0028204143,
0.010893304,
0.008731472,
0.038369287,
0.0088803405,
-0.0077994247,
0.024738092,
0.02447919,
0.0071910047,
-0.0039417837,
-0.028064983,
0.018809235,
0.025411237,
-0.020906342,
0.011579394,
0.017204043,
0.020000184,
-0.040828854,
-0.010161906,
-0.0077411714,
0.011572922,
-0.0022022857,
-0.013359346,
-0.014330229,
0.018485608,
0.015534123,
-0.0013479089,
0.001794515,
0.01956005,
-0.035702594,
0.004598748,
0.013165169,
-0.008789725,
-0.003038863,
0.002124615,
0.014136053,
-0.018123144,
-0.001385126,
-0.010000092,
0.018226705,
0.0013001738,
0.029463055,
-0.021204079,
-0.011786516,
0.0017168443,
-0.023495361,
0.01222665,
0.02321057,
-0.009993619,
-0.010970974,
0.005812351,
-0.0103755,
-0.018990466,
0.01745,
-0.012627948,
0.0027039084,
0.011650593,
0.010582621,
-0.0032589296,
0.0060841986,
0.03624629,
0.0014773599,
-0.019909568,
-0.011307548,
0.009314002,
-0.0153787825,
-0.0009894914,
-0.0042913016,
-0.03000675,
0.018045474,
0.028453337,
-0.020971067,
-0.0047929245,
0.016077818,
0.026615132,
0.0073657637,
-0.01948238,
0.0078576775,
-0.0014538969,
0.007993601,
0.024802817,
0.00055218954,
0.0097282445,
0.0012937012,
-0.0054434156,
0.018990466,
0.030032638,
0.025786646,
-0.012796234,
-0.025644248,
-0.0066117113,
0.019456489,
-0.041191317,
-0.012026001,
-0.0048738313,
-0.01805842,
-0.0132493125,
0.017268768,
0.012407881,
-0.015896587,
-0.01390304,
0.022951668,
0.011242822,
-0.029799627,
0.012479079,
0.0014636057,
0.0124014085,
0.018433826,
-0.013178115,
-0.010213686,
0.019857788,
0.018498553,
0.011106898,
-0.006313974,
-0.0036440464,
0.0041100704,
-0.018252594,
-0.0057314443,
0.0018657129,
-0.0007969329,
-0.005786461,
0.002959574,
0.0036472827,
-0.0032265668,
-0.028634567,
-0.009171605,
-0.01699692,
-0.0127703445,
-0.012511442,
-0.033217136,
0.0053074923,
0.030990576,
-0.04020749,
0.017644174,
0.014084272,
0.042563498,
0.02508761,
0.01686747,
0.00057686615,
0.019689502,
-0.0040809438,
0.0002259325,
0.0052751293,
-0.0074628517,
0.025941987,
0.026977595,
-0.00717806,
0.020440318,
-0.03249221,
-0.009676465,
0.018524442,
0.008038909,
-0.030887015,
0.014757417,
0.013644138,
0.01382537,
-0.014602076,
-0.014822143,
-0.01133991,
-0.033087682,
-0.03018798,
0.011346383,
-0.020556824,
0.008731472,
0.0034013258,
-0.006252485,
0.016090764,
0.02886758,
-0.023249405,
-0.019055191,
-0.011346383,
0.0077282265,
0.018394992,
-0.007475797,
0.009126297,
0.013411127,
0.02658924,
-0.005799406,
0.012789762,
-0.019119916,
0.00084466796,
0.0081618875,
0.0054304707,
-0.066227145,
-0.6387632,
-0.028401555,
0.0023268822,
0.0062330673,
-0.012446716,
0.05405875,
0.010388445,
-0.0072363126,
-0.028401555,
0.038213942,
0.0058479505,
0.023754263,
0.019391764,
0.0018106963,
0.00080785534,
-0.020336756,
0.00050769077,
-0.019611832,
0.023637759,
0.009650574,
-0.017851297,
0.011165151,
0.0037346622,
-0.009780025,
0.010899777,
0.013132807,
-0.00084143167,
-0.02513939,
0.0030242996,
0.025514798,
-0.007618193,
0.025941987,
-0.002101961,
0.0078576775,
0.050926033,
0.0100454,
0.0037022994,
0.019572996,
0.023482418,
0.024194397,
0.013029246,
0.00058091147,
-0.004611693,
-0.005265421,
-0.009572904,
0.024776926,
-0.006258957,
0.00049595925,
0.038602296,
-0.020738054,
0.009508179,
-0.0010250903,
-0.014485571,
-0.019171698,
0.018174924,
-0.0037767338,
0.021890169,
-0.025230005,
0.0340974,
-0.011747681,
0.013346401,
0.042045694,
-0.02003902,
-0.008025964,
-0.014809198,
-0.0024466245,
-0.03394206,
0.012653838,
-0.0014579422,
-0.034589317,
0.012951575,
0.034304522,
-0.005093898,
0.005789697,
0.015158716,
0.0016043837,
0.013993656,
0.0200908,
-0.020026075,
0.00036306967,
-0.00015968998,
0.015352892,
-0.034459863,
0.0021683048,
0.01805842,
0.0012928921,
-0.0059547476,
0.017204043,
-0.011825352,
0.00010270119,
0.014006602,
0.0040162182,
-0.01818787,
-0.03148249,
-0.0042524664,
0.028738128,
-0.0032573114,
0.00078843767,
0.007359291,
0.018226705,
-0.026097327,
0.0042459937,
-0.0060291816,
0.011767099,
0.05123672,
0.025786646,
-0.025501853,
0.015547069,
0.048233453,
-0.00140778,
0.009320474,
0.004728199,
-0.003521068,
-0.014187833,
-0.011456416,
-0.023327075,
0.002451479,
-0.005812351,
0.015495288,
-0.017113427,
0.0104013905,
-0.009747663,
-0.020958122,
-0.009948311,
0.0039061848,
-0.0032573114,
0.01435612,
-0.029152371,
-0.008912703,
-0.0020501807,
-0.019883677,
-0.024945213,
-0.004598748,
-0.009870641,
0.012983939,
-0.016220214,
0.009598793,
-0.01641439,
-0.00076214294,
-0.014964539,
-0.018602112,
-0.0033074738,
-0.007307511,
0.010356083,
-0.01382537,
-0.0011602049,
-0.007922403,
-0.020194361,
-0.0044725332,
-0.019896623,
0.0141619425,
-0.0038188053,
-0.019650666,
0.04789688,
0.006077726,
-0.011631175,
-0.0034887053,
0.0026278559,
-0.01075738,
-0.010317247,
0.021618322,
0.01200011,
-0.003061517,
0.015443508,
-0.013657084,
-0.023391802,
0.0011998492,
0.007087444,
-0.013449962,
-0.029721957,
-0.0041100704,
-0.005495196,
-0.02871224,
0.009948311,
0.019754227,
0.0140972175,
-0.00080219185,
-0.0244533,
0.0016634457,
-0.013786535,
-0.022174962,
-0.0140972175,
-0.014912759,
-0.0020242904,
0.033217136,
0.010576149,
0.030420993,
0.013670029,
0.0087703075,
0.04271884,
0.024246179,
0.056285307,
0.010038927,
0.00054248073,
-0.005071244,
-0.013126334,
0.024932269,
0.0032233307,
0.01032372,
0.010951557,
0.015818916,
-0.002922357,
0.030317431,
-0.012725037,
0.03787737,
-0.04111365,
0.0044401702,
0.0005388399,
0.022330303,
-0.008912703,
-0.0111845685,
0.009100407,
0.00358903,
-0.020517988,
-0.017009865,
0.029696066,
0.009754135,
-0.00019609809,
0.0031068248,
-0.035935607,
-0.017916022,
0.008815615,
-0.0047476166,
-0.016479116,
-0.00072128495,
0.028168544,
0.03671231,
0.0024110253,
0.010271939,
-0.020194361,
0.00485765,
0.0016399827,
-0.007391654,
0.028401555,
-0.020945176,
0.0047993967,
-0.00017728723,
0.016983975,
0.023223516,
0.001794515,
0.003027536,
-0.014084272,
-0.0016246104,
0.004915903,
0.009844751,
0.010310775,
0.035624925,
0.045747995,
-0.019145807,
0.016530896,
-0.030110309,
0.007449907,
-0.0045404946,
0.008996846,
-0.010524369,
-0.009547014,
0.01451146,
0.002089016,
0.03614273,
0.01694514,
0.031508382,
-0.02077689,
-0.01509399,
-0.007087444,
-0.012479079,
-0.007631138,
-0.0036667003,
-0.029618395,
0.018394992,
0.013670029,
-0.024362683,
0.0022152308,
-0.023508307,
-0.033320695,
0.0017864242,
0.012718564,
0.0034013258,
0.005479015,
0.03528835,
0.010912722,
-0.024129672,
-0.024323849,
0.024543915,
0.0264339,
-0.027029375,
-0.02387077,
0.0052913106,
-0.024919324,
-0.0022945195,
-0.0031310967,
-0.030602224,
0.029592505,
-0.011443471,
0.015352892,
-0.011540559,
-0.0003654969,
0.028582787,
0.00405829,
0.0067767613,
-0.00976708,
-0.020026075,
0.014744473,
-0.011682956,
-0.01042728,
0.026537461,
0.02064744,
-0.007928875,
0.019521216,
-0.00405829,
-0.022964614,
0.007605248,
-0.01443379,
-0.01385126,
0.017281713,
0.0027831972,
-0.0058317687,
-0.005653774,
0.010835052,
0.0317155,
0.004006509,
-0.011113371,
-0.022938723,
-0.008077744,
0.004187741,
0.03629807,
0.02384488,
-0.027184715,
0.014174888,
0.009145715,
0.024207342,
-0.022990502,
-0.014990429,
0.025540689,
0.005433707,
-0.04427225,
-0.016090764,
0.010038927,
-0.002616529,
0.020000184,
0.022291467,
-0.0018721855,
-0.027935533,
0.000064118714,
0.0003185709,
0.018640948,
-0.004423989,
0.010025982,
0.029048812,
0.020297922,
-0.011482307,
-0.014265504,
0.01167001,
0.0048414683,
-0.00847257,
-0.012848015,
0.012174869,
-0.009721773,
0.021657158,
0.023275295,
-0.008310756,
-0.004919139,
0.014938649,
0.005093898,
-0.0057249716,
0.012789762,
-0.0021456508,
0.010213686,
-0.0027993785,
0.0026909632,
-0.012440244,
0.0026941996,
-0.0054434156,
0.00943698,
-0.029592505,
0.0042913016,
-0.0061909957,
-0.017385274,
0.0033495454,
0.024893433,
-0.013682974,
0.016556786,
-0.031793173,
0.0010639257,
-0.01927526,
-0.0065308046,
-0.016673293,
0.016000148,
-0.01821376,
-0.008388427,
-0.014563241,
0.005469306,
0.017747736,
-0.00816836,
-0.025152335,
0.008893286,
-0.010860941,
-0.024103781,
-0.00022573023,
0.0152493315,
0.016297884,
0.0038900035,
-0.034874108,
0.021411201,
0.03477055,
-0.017087536,
-0.016323775,
0.0022039039,
-0.01874451,
0.005220113,
0.018459717,
0.0025857843,
-0.036220398,
0.010110125,
0.022951668,
0.010835052,
-0.024776926,
0.012414354,
0.011987166,
-0.019780118,
-0.005818824,
0.011534086,
0.0351589,
-0.0116635375,
-0.010886831,
0.009475815,
-0.017281713,
-0.019094028,
-0.031870842,
-0.0052395305,
-0.03394206,
-0.0051036067,
-0.017126372,
0.0010970975,
-0.029747847,
-0.014446734,
0.00039482565,
0.024233233,
0.011106898,
0.017216986,
0.012757399,
0.008835033,
0.019572996,
-0.0007346346,
-0.00033192054,
0.0026310922,
-0.015106935,
0.031870842,
-0.011611758,
-0.035832044,
0.011508197,
0.0065987664,
-0.018524442,
-0.013967766,
0.00033313414,
0.00082808203,
0.049890425,
0.011210459,
-0.028738128,
-0.0314566,
-0.0033171827,
-0.025450073,
0.00007504114,
0.0030016457,
0.0058382414,
-0.010155433,
-0.0044660605,
-0.030628113,
-0.00091991137,
0.031508382,
-0.039534345,
-0.017411163,
0.0071974774,
0.0253724,
0.0038867672,
-0.03249221,
-0.0021650684,
-0.032388646,
0.0010032455,
0.0028592497,
-0.00394502,
0.015883641,
0.0037832062,
0.027365947,
0.031741392,
0.026563352,
-0.004530786,
0.005621411,
0.02638212,
0.01311339,
0.012071309,
-0.010602039,
0.019624775,
-0.012381991,
0.001326064,
0.005394872,
0.0070486087,
0.05395519,
-0.020880451,
0.016738018,
0.009987147,
0.015676519,
-0.036971215,
-0.00018790626,
-0.05152151,
-0.020984013,
0.009391672,
-0.00789004,
0.014304339,
-0.035573144,
-0.026666911,
0.006045363,
0.012246068,
0.009326947,
-0.026239723,
0.025540689,
-0.020906342,
0.012970993,
0.009417563,
-0.008602021,
-0.011385218,
-0.0338385,
0.020634495,
0.0046181655,
0.028582787,
-0.001969274,
0.022498589,
0.018446771,
0.0029401565,
-0.0036764091,
0.008602021,
-0.02500994,
-0.0038641132,
-0.020323811,
-0.024880487,
-0.03132715,
-0.019689502,
-0.008362536,
-0.03924955,
0.0060518356,
0.023987276,
-0.0030550442,
0.01866684,
-0.016802743,
-0.026563352,
0.0007152169,
-0.0065210955,
0.0070227184,
-0.016323775,
0.0274954,
0.03414918,
-0.014498515,
-0.017152261,
0.0049223755,
0.0150681,
0.018848069,
0.03427863,
0.0047929245,
-0.01963772,
0.012511442,
-0.014058382,
0.00244177,
-0.028893469,
-0.024893433,
0.025553633,
0.007055081,
0.0052880747,
-0.0021990493,
-0.013307566,
0.010867414,
-0.006420771,
-0.031353038,
-0.011346383,
-0.004025927,
-0.019624775,
-0.007883567,
0.0072880927,
0.0016796271,
-0.0014951593,
-0.007935348,
-0.024828708,
0.0023123191,
-0.0026213834,
-0.0026844908,
0.007100389,
0.0015072954,
0.019780118,
-0.021760719,
0.0031068248,
0.0013689446,
0.014835088,
-0.00056958455,
-0.005902967,
-0.028556896,
0.037696138,
-0.017488834,
-0.011119843,
0.0055663944,
-0.001760534,
-0.0050227,
-0.004035636,
0.0059806374,
-0.023081118,
-0.013152225,
-0.00091020257,
0.023327075,
0.007301038,
0.0017815698,
0.014420845,
-0.02400022,
0.014731527,
-0.019831898,
-0.027987313,
0.009747663,
-0.035832044,
-0.0140324915,
0.00019670489,
0.008427262,
0.02463453,
0.0065049143,
-0.01379948,
0.001043699,
0.02561836,
-0.019094028,
0.01131402,
-0.0043236646,
0.0014118253,
-0.017941913,
0.0008754126,
-0.0057799886,
0.016427336,
0.009042154,
-0.011721791,
-0.030343322,
0.0034336885,
-0.007521105,
0.020336756,
0.022848107,
-0.023404745,
0.043599106,
-0.020738054,
0.0122719575,
0.013915986,
-0.022239687,
0.000598711,
-0.00921044,
0.016983975,
-0.01225254,
0.012712091,
-0.0116635375,
0.022977557,
-0.004504896,
0.014666801,
0.0049741557,
-0.0019385292,
-0.01927526,
0.0113658,
-0.008440207,
-0.0084660975,
-0.0038997123,
-0.023987276,
-0.009890059,
0.009534068,
0.008582603,
-0.0064854966,
-0.029126482,
0.016492061,
-0.0070162457,
0.013721809,
-0.000074029806,
0.0023123191,
-0.0015226677,
-0.02765074,
-0.0290747,
-0.019521216,
-0.014110162,
0.0340974,
0.03787737,
0.011145733,
0.0020582713,
-0.0019029301,
-0.03637574,
-0.003543722,
-0.012569695,
-0.007275148,
0.0055922843,
0.03293234,
-0.008479042,
0.012602057,
0.013631193,
0.01686747,
-0.0059806374,
-0.010634402,
0.025048774,
-0.020893397,
-0.00596122,
0.008084217,
0.0029611923,
-0.0030712257,
0.03029154,
-0.0029676647,
-0.038110383,
0.028427446,
-0.0061877593,
0.022899887,
-0.025268842,
0.017061645,
0.00551785,
-0.009695882,
0.021799553,
-0.011456416,
0.00260682,
0.0085761305,
-0.009747663,
-0.009145715,
-0.002559894,
-0.0028738128,
0.002546949,
-0.012194287,
0.0016763909,
-0.013877151,
0.0038349868,
-0.013346401,
0.01578008,
0.019327039,
-0.010103653,
0.010187796,
0.011987166,
-0.003098734,
-0.013165169,
-0.003224949,
0.0019110208,
-0.018757455,
-0.0005275129,
-0.00028378092,
0.0019886915,
-0.013081026,
0.011818879,
-0.04046639,
0.0005351991,
-0.020466208,
-0.016026037,
-0.03272522,
0.033605486,
-0.011203987,
-0.013081026,
0.010174851,
0.00027508344,
-0.0170487,
-0.007184532,
-0.0008721763,
0.013657084,
-0.0022637749,
0.0025728391,
0.018032528,
-0.023547143,
-0.0026569823,
0.0028786673,
-0.024220288,
-0.026822254,
0.007417544,
0.19645488,
-0.0027864333,
0.01227843,
0.004239521,
-0.007792952,
-0.006912685,
-0.0037120082,
0.006242776,
-0.011514669,
0.023624813,
0.0035243044,
0.008938594,
-0.015339947,
0.008977429,
0.007877096,
-0.02199373,
-0.026666911,
-0.020453263,
-0.013035718,
-0.0011391691,
0.025579523,
-0.0069321026,
-0.004203922,
-0.0068479595,
0.052427668,
-0.005809115,
-0.014446734,
-0.0075016874,
0.018174924,
0.013527633,
-0.02780608,
-0.0075405226,
0.007443434,
0.009993619,
-0.02011669,
-0.011255767,
-0.019585941,
-0.0013972621,
0.0010226631,
0.004614929,
0.0075664124,
0.011585867,
-0.009935367,
0.00610038,
-0.023094064,
0.010148961,
0.014977484,
-0.030835235,
-0.0053463276,
0.0060356543,
-0.026615132,
0.0039288388,
0.0016367465,
0.022498589,
0.025204115,
-0.008602021,
0.0020922523,
0.038576405,
0.001912639,
0.016323775,
0.0022039039,
-0.005835005,
-0.044608824,
0.028090874,
-0.011572922,
0.037980933,
-0.01329462,
-0.018019583,
0.019818952,
-0.011048646,
0.017242877,
-0.029152371,
-0.009326947,
0.009812388,
0.00689974,
-0.009385199,
0.047404967,
0.019844843,
0.015637685,
0.00809069,
0.00027508344,
0.0231329,
-0.037307788,
-0.014485571,
-0.015352892,
-0.04258939,
0.024893433,
-0.0016505006,
-0.0134240715,
-0.017061645,
0.0030323903,
0.007430489,
-0.007262203,
0.008912703,
0.0097929705,
-0.0014045436,
0.020634495,
-0.015818916,
-0.00013693492,
-0.017566504,
-0.021734828,
0.060686644,
-0.010595567,
0.021579487,
-0.014886868,
-0.009242804,
-0.007223367,
0.019365873,
0.0013746081,
0.004317192,
-0.021204079,
-0.029281823,
-0.00009693657,
-0.008627911,
-0.016893359,
0.03650519,
0.012731508,
-0.0026941996,
0.029437164,
-0.009721773,
-0.0033107102,
-0.023689538,
-0.009935367,
0.018809235,
-0.0049806284,
0.0038188053,
-0.023223516,
0.0072039496,
-0.013812425,
-0.052013423,
-0.0046699457,
0.008440207,
-0.005068008,
0.003333364,
-0.0072104223,
-0.0070744986,
0.010841523,
0.00082686846,
0.010142488,
0.01963772,
-0.0059288573,
-0.013475852,
0.019883677,
-0.00008657038,
0.0074693244,
-0.022395028,
0.011462889,
0.013255785,
-0.008511405,
-0.013682974,
-0.027132936,
-0.019831898,
-0.005530795,
-0.009825333,
-0.009158661,
-0.024893433,
-0.01927526,
-0.029230043,
-0.028246215,
0.009547014,
-0.02884169,
0.031637833,
0.0022475936,
0.004776743,
0.006783234,
-0.023831934,
-0.16103709,
0.007579358,
0.006116561,
-0.011903022,
-0.0053689815,
0.006679673,
0.011210459,
0.0016634457,
0.013514687,
-0.006349573,
0.012330211,
-0.043702666,
-0.016776854,
0.012349628,
0.02077689,
-0.003123006,
-0.008712054,
0.032155637,
0.0040777074,
-0.001889985,
0.022783382,
-0.023119954,
0.020763945,
-0.013695919,
0.014369064,
0.008291339,
0.013449962,
-0.004902958,
-0.020841615,
-0.012634421,
-0.0128156515,
-0.022990502,
0.034408085,
0.016207268,
0.012174869,
-0.013320511,
-0.0064013535,
-0.012498497,
-0.0012492024,
0.003967674,
0.03746313,
0.051883973,
0.014886868,
0.011993638,
0.0069774105,
0.015430563,
0.016621511,
-0.008737944,
0.0009708827,
0.018809235,
0.021126408,
0.017152261,
0.007436962,
0.03280289,
0.017100481,
0.008666746,
0.0103755,
0.013016301,
-0.0022330303,
0.00051456783,
-0.0150681,
-0.009359309,
0.026149107,
0.016828634,
0.0060874345,
-0.020996956,
-0.0063301553,
-0.0028560134,
-0.0200908,
0.019094028,
-0.017255822,
-0.029178262,
0.016375555,
-0.016103707,
0.014692692,
0.02651157,
-0.010770326,
0.008822087,
-0.0013066464,
-0.009890059,
-0.019210532,
0.00394502,
-0.02645979,
-0.014407899,
-0.033191245,
-0.0044304617,
0.009825333,
0.011229876,
0.00094418344,
-0.02146298,
-0.017359383,
-0.012356101,
0.025734864,
-0.026045548,
0.0200908,
0.030757565,
-0.010576149,
0.0013568086,
-0.0031731683,
0.013359346,
0.0053528002,
-0.003637574,
-0.019754227,
0.006417535,
0.030420993,
-0.008330174,
-0.03236276,
-0.0012597203,
0.027055265,
-0.019909568,
0.0134240715,
0.013126334,
0.010200741,
0.02516528,
-0.016880414,
0.018200815,
0.00347576,
0.0019967821,
0.0043754447,
-0.0047443802,
0.06897151,
0.0048738313,
0.00082444126,
0.015883641,
0.012246068,
-0.019236423,
-0.12779406,
-0.03772203,
-0.004333373,
0.028297994,
0.0033657267,
-0.005915912,
0.011197514,
0.05908145,
-0.0349,
0.02191606,
-0.002957956,
-0.009236331,
-0.0049515017,
-0.008569658,
0.01390304,
-0.010038927,
0.019469434,
0.007087444,
-0.031508382,
0.02884169,
-0.0094240345,
0.0117929885,
0.02138531,
-0.02024614,
0.0022233215,
0.00039624152,
-0.034692876,
0.013035718,
-0.004307483,
0.03023976,
0.01768301,
-0.009339891,
-0.0031472782,
0.0076893913,
0.001608429,
-0.019857788,
0.007301038,
0.0010671619,
0.038006824,
-0.007449907,
-0.004598748,
-0.009346364,
0.016828634,
0.023663647,
0.008317228,
-0.009760608,
-0.025411237,
-0.0025793118,
0.012595586,
-0.018019583,
-0.03158605,
-0.00027629704,
-0.020958122,
-0.0038900035,
0.011657065,
-0.016168434,
0.012427299,
0.017372329,
-0.025864316,
-0.021488871,
-0.0032200944,
0.0032120037,
-0.028168544,
-0.015288167,
0.017695956,
-0.014084272,
-0.034874108,
-0.03521068,
0.0025615122,
-0.027340058,
0.005563158,
-0.009456398,
-0.008983902,
-0.0003066371,
-0.02072511,
0.018032528,
-0.010783271,
-0.016090764,
0.0037767338,
-0.0029838462,
-0.020272031,
-0.000498791,
0.024362683,
-0.014213723,
0.006880322,
0.006268666,
0.014809198,
-0.00051456783,
-0.014951594,
-0.015301112,
-0.0153787825,
0.01646617,
-0.009314002,
0.00032807744,
-0.014951594,
0.008252503,
-0.010602039,
-0.03611684,
0.017398218,
0.031793173,
-0.030524552,
-0.03293234,
-0.032000296,
0.010550259,
0.016828634,
-0.0047217263,
0.00361492,
0.002708763,
0.008038909,
-0.012925685,
-0.010090708,
0.01032372,
-0.0071133343,
-0.0025987295,
-0.001091434,
0.0027556887,
-0.024336794,
-0.022032565,
0.0388612,
0.0044434066,
0.013372292,
0.03293234,
0.016686238,
0.030446881,
0.00014765508,
0.023469472,
-0.024246179,
-0.025929041,
-0.013462907,
0.019456489,
-0.00039603925,
-0.0043851538,
0.022343248,
-0.029178262,
0.0030356266,
-0.00022269622,
-0.0046472917,
-0.018174924,
0.006197468,
0.01585775,
0.027055265,
0.04015571,
0.0033721994,
-0.047948662,
-0.0019628012,
-0.03280289,
-0.02440152,
-0.0075923027,
-0.043780338,
0.00022431437,
0.01161823,
-0.003087407,
0.051133156,
0.01826554,
0.0010962884,
-0.027365947,
-0.024077892,
0.01633672,
0.010013037,
-0.008893286,
-0.011760626,
-0.012246068,
0.018459717,
0.0065049143,
0.00695152,
0.015572959,
0.00043366096,
-0.009689409,
-0.034537535,
0.01390304,
-0.016932195,
-0.0024482426,
-0.002993555,
0.0190293,
0.008258976,
0.007029191,
0.0033819082,
-0.0124661345,
-0.021346474,
-0.015547069,
-0.004589039,
0.0036828818,
-0.0010469352,
-0.003110061,
-0.024272067,
0.011074536,
0.014899814,
-0.008038909,
0.0084660975,
0.010796216,
0.008653801,
-0.0011618229,
0.007909458,
0.03018798,
-0.007443434,
0.007301038,
0.011754153,
0.004074471,
-0.012207232,
-0.019728336,
0.0052848384,
0.011398163,
-0.004038872,
-0.007747644,
-0.019883677,
-0.019831898,
-0.019456489,
0.026796363,
-0.034537535,
-0.03624629,
0.010614985,
-0.0163885,
0.016207268,
0.005116552,
-0.003064753,
0.0013721809,
-0.013126334,
0.02450508,
0.0066732005,
-0.00080785534,
-0.007132752,
0.02130764,
0.01702281,
-0.005948275,
-0.001151305,
0.037230115,
0.0062848474,
-0.0064466614,
0.024673367,
-0.029437164,
0.016776854,
-0.0134240715,
0.0016844815,
-0.041864462,
-0.036194507,
0.003954729,
-0.014744473,
-0.032155637,
0.019068137,
0.042252816,
-0.012906267,
0.07689391,
0.0068479595,
0.0024789872,
-0.0038090965,
-0.0052751293,
0.0033107102,
-0.010161906,
0.00933342,
-0.0013009829,
-0.015987203,
0.0036116836,
-0.025734864,
0.029592505,
-0.03127537,
-0.021695992,
0.0046990723,
-0.00488354,
0.0010809161,
-0.009650574,
-0.026537461,
0.023042284,
0.003909421,
-0.007631138,
-0.008906231,
-0.014731527,
0.0067443987,
0.0504859,
-0.011281657,
0.0043722084,
-0.020789836,
-0.014925703,
0.009307529,
-0.024362683,
-0.013016301,
0.016686238,
-0.023301186,
0.0054498883,
-0.004495187,
0.0094240345,
-0.0040777074,
-0.011326965,
0.035003558,
-0.014265504,
-0.020453263,
-0.00036448555,
-0.010556731,
-0.019974293,
-0.0257737,
-0.016725073
] |
The T-cell receptor (TCR) consists of a TCRαβ heterodimer, a TCRζ homodimer, and CD3γε and CD3δε heterodimers. The precise mechanism of T-cell triggering following TCR ligand engagement remains elusive. Previous studies reported that the cytoplasmic tail of CD3ε binds to the plasma membrane through a basic residue-rich stretch (BRS) and proposed that dissociation from the membrane is required for phosphorylation thereof. In this report we show that BRS motifs within the cytoplasmic tail of TCRζ mediate association with the | [
-0.031521656,
-0.004262797,
-0.015760828,
-0.022278463,
-0.0011883164,
0.030204961,
-0.011606658,
0.000931561,
-0.016972186,
-0.021554282,
0.006807308,
-0.0055004894,
-0.023305485,
0.016287506,
-0.0043022977,
0.0058066207,
0.009829121,
-0.0003081887,
-0.011784412,
0.0029609157,
-0.018012375,
0.0052503175,
-0.006511052,
-0.0071496484,
-0.0053984453,
0.0019026229,
0.031073978,
-0.04479393,
-0.012758765,
-0.0044899266,
-0.008433425,
0.021093437,
-0.026807891,
0.011033896,
0.0052338587,
-0.012383508,
0.0123571735,
0.0046183043,
0.020277089,
0.01364095,
0.0069258106,
0.033944372,
0.017367193,
0.0063168397,
-0.003936915,
-0.011481572,
0.021764953,
-0.014325631,
-0.020803766,
0.030705305,
0.017077522,
0.0061094603,
-0.0091839405,
-0.01961874,
-0.028335255,
-0.010823225,
0.0027436612,
0.0208696,
0.0240165,
-0.034708053,
-0.016748348,
-0.013423695,
0.0010368965,
-0.0030251045,
0.013798953,
0.024029667,
0.000023042145,
0.007926498,
-0.0116527425,
-0.0065571363,
0.022528635,
0.023608323,
-0.009190524,
-0.0015076146,
0.026228545,
0.0004048834,
-0.020198086,
-0.016577179,
-0.0046413466,
0.009690868,
0.012567844,
-0.016011,
-0.0001740505,
0.032891016,
0.016590344,
-0.0033509864,
0.02693956,
0.008900852,
0.016419174,
-0.020961769,
0.013476363,
0.016300673,
0.013746286,
0.034497384,
-0.0008764245,
-0.012699514,
0.004200254,
0.021317277,
-0.022712972,
-0.024819683,
-0.004328632,
0.012679763,
-0.012455925,
-0.013575115,
-0.03971149,
-0.022581302,
0.0070048124,
-0.013199857,
0.0021560865,
-0.010507219,
-0.013436862,
0.025320025,
-0.020974936,
-0.041317858,
0.027729576,
0.028519593,
-0.00029502175,
-0.0066295546,
-0.018670721,
0.006892893,
0.0104940515,
0.022186294,
0.005033063,
0.0048618927,
0.018947227,
0.017893871,
-0.011567157,
-0.0043780077,
-0.010105627,
-0.0053622364,
0.035182063,
0.014733806,
-0.02005325,
0.003690035,
-0.024964519,
0.0056683677,
-0.020369256,
0.006794141,
-0.0033378194,
-0.035103064,
0.0015438237,
0.028466925,
0.005467572,
-0.01151449,
0.027782245,
0.028940935,
0.019434404,
0.0106454715,
-0.018433716,
0.01686685,
-0.005951457,
0.0027897456,
0.012771932,
-0.009499948,
-0.01157374,
0.009394612,
-0.02185712,
0.028993603,
0.00087889325,
-0.03128465,
0.003041563,
0.0028127877,
0.013575115,
-0.0008110012,
0.033338692,
0.033338692,
0.017749036,
0.0125085935,
0.00055095414,
-0.010368966,
-0.00417392,
0.025873037,
0.00023577052,
0.0056848265,
-0.035735074,
0.0015495843,
0.008058167,
-0.003640659,
-0.016498176,
-0.007465655,
-0.010698139,
-0.006873143,
0.029362276,
-0.0058428296,
-0.0073010684,
-0.01187658,
0.010118794,
-0.019987416,
-0.009585532,
-0.034997728,
-0.004203546,
0.007419571,
0.0084795095,
-0.024622178,
-0.6227436,
-0.012982603,
0.006998229,
0.00018289703,
0.008808683,
0.03541907,
0.0065077604,
0.0038579134,
-0.013904289,
0.02237063,
-0.00046413465,
0.00083733513,
-0.004085043,
-0.036525093,
-0.032390673,
-0.024740681,
0.00088136207,
0.009164191,
0.022502301,
0.0026547844,
-0.013759453,
-0.016195336,
-0.008459759,
0.02215996,
-0.0147864735,
-0.004634763,
-0.0020359382,
-0.012877268,
0.0036077416,
0.025425361,
-0.002521469,
0.008611179,
0.0023371319,
-0.020079585,
0.041133523,
-0.0073339855,
-0.012627096,
0.029441278,
0.02607054,
0.023134314,
0.0005735848,
-0.00043862368,
0.025122521,
0.010652055,
-0.03570874,
0.010079293,
0.0027815162,
0.00002377507,
0.0042463383,
-0.0066130958,
0.023213316,
-0.0069653112,
-0.017117022,
0.009012771,
0.01381212,
-0.0038480384,
0.009085189,
-0.008505844,
-0.0030448548,
0.000263956,
-0.010375549,
0.006859976,
-0.012100418,
-0.030836973,
-0.0063793827,
-0.008472926,
-0.0176832,
0.007491989,
0.010994395,
0.014825975,
0.0043812995,
0.022607636,
0.0014327277,
-0.0063563404,
-0.007215483,
0.034866057,
0.0076894932,
0.009888372,
0.015866162,
0.029809952,
-0.004934311,
-0.0002688936,
-0.011600074,
0.014180794,
0.028624928,
-0.010974645,
-0.009137857,
0.018223045,
-0.00097023894,
0.024516843,
0.009802787,
0.0067283064,
-0.009671117,
-0.00007272677,
-0.022067793,
0.018236212,
0.0022910477,
0.006191754,
-0.0071298983,
-0.003578116,
-0.011995083,
-0.040053833,
0.008900852,
0.0014121543,
0.009322193,
-0.016432341,
-0.037183437,
0.005556449,
0.07884364,
-0.027571572,
-0.004085043,
0.002546157,
-0.007906748,
0.0029888954,
-0.002174191,
-0.017656866,
0.0061193355,
0.037789118,
0.01971091,
-0.029019937,
0.018710222,
0.019315902,
0.0050133127,
-0.01058622,
0.028308922,
0.013851621,
0.0041311276,
-0.0272819,
-0.0010130315,
-0.006208212,
0.020895934,
0.0040883347,
0.02052726,
-0.01682735,
0.029467613,
0.0032588176,
0.02267347,
0.009598699,
0.0014343736,
-0.03989583,
-0.03465539,
-0.01777537,
0.008433425,
-0.008203004,
-0.017117022,
-0.010171461,
-0.015168315,
-0.005829663,
0.00544453,
-0.013838454,
0.035735074,
0.008703347,
0.0026778264,
-0.0153789865,
0.004075168,
-0.0018433717,
-0.02547803,
-0.009796203,
0.0053161522,
-0.013575115,
-0.017551532,
0.006873143,
-0.01842055,
0.018486384,
0.0023865078,
-0.0045294273,
0.013956957,
0.006050209,
-0.0030267504,
-0.052615095,
0.006237838,
-0.00738007,
-0.035392735,
0.02194929,
-0.0015174899,
0.020593094,
-0.009058855,
-0.021830786,
0.019724077,
-0.012910184,
-0.013733119,
-0.014812808,
-0.011000979,
-0.014022792,
0.021277776,
-0.011883164,
0.036077417,
0.018091375,
0.0030777722,
0.039211147,
-0.029625615,
0.004483343,
-0.022963144,
0.03215367,
0.0065406775,
-0.017419862,
0.035392735,
0.019855745,
-0.03386537,
0.024332505,
-0.00663943,
0.005072564,
0.022449633,
-0.026821056,
-0.0012475676,
-0.012416424,
0.00787383,
-0.0062674633,
0.004749974,
0.018170377,
-0.0013981644,
-0.0031386693,
0.011494739,
-0.0071496484,
-0.0023190274,
0.015892496,
0.0022696513,
0.006622971,
0.0023618198,
-0.013331527,
-0.0026383256,
0.019895246,
0.03136365,
-0.007952832,
-0.010915393,
-0.004361549,
0.005566324,
0.019487072,
-0.014773307,
-0.0074393214,
-0.021106604,
-0.0055334065,
-0.004312173,
0.02069843,
0.013245942,
0.0040587094,
0.007893581,
0.0026745347,
0.02500402,
-0.0026235129,
0.0045853867,
0.025438529,
-0.023318652,
-0.008124002,
-0.005164732,
-0.015694993,
0.012969436,
0.015523823,
-0.0057078684,
0.010099043,
-0.004048834,
0.027861245,
-0.02439834,
0.011237984,
0.0072023165,
0.004157461,
0.020922268,
0.015365819,
0.04463593,
0.030283963,
0.016801016,
0.0053852787,
0.024674846,
-0.014325631,
-0.0050528133,
0.017196024,
-0.016590344,
0.0029839578,
-0.014088626,
0.006274047,
-0.0030349798,
0.00010461546,
0.008091085,
-0.014918143,
-0.012423008,
0.0054346547,
0.02117244,
0.0014335506,
-0.0044208,
-0.0020688556,
-0.016945852,
-0.04015917,
0.022620803,
0.031811327,
-0.030547302,
-0.0075183227,
-0.034497384,
0.007900164,
-0.0013701847,
0.022778807,
-0.009072022,
-0.0017495572,
0.020724764,
0.005105481,
-0.0000642917,
-0.023845328,
0.031179314,
-0.01060597,
0.016511343,
0.0012146502,
0.0139306225,
0.012528344,
-0.023766328,
0.0077816616,
0.048191,
-0.0043845912,
-0.00834784,
-0.02676839,
0.0053885705,
-0.018578554,
0.0019964373,
-0.02358199,
-0.0051120645,
-0.03623542,
0.016708847,
-0.009954207,
0.004433967,
0.023766328,
0.005467572,
-0.0058823307,
-0.01678785,
-0.0096250335,
0.008367591,
-0.006669055,
0.0033032561,
0.042107876,
-0.005276651,
0.029283276,
-0.0019733952,
0.0025527405,
-0.0043780077,
-0.02453001,
0.01747253,
0.0066032205,
-0.036077417,
-0.0064155916,
0.012712681,
0.007906748,
0.0074722385,
0.02039559,
0.010935144,
-0.01751203,
0.024240337,
0.007123315,
0.018947227,
0.0011899623,
0.024569511,
0.019842578,
0.015036645,
-0.009855455,
0.018670721,
0.019263234,
0.00961845,
-0.036130086,
0.0160505,
-0.0064682593,
-0.008301755,
-0.00688631,
-0.008426841,
-0.026663054,
-0.012258422,
0.040080167,
-0.008802099,
0.008900852,
0.0076368256,
0.0054741553,
0.00882185,
0.00079001643,
-0.0044010496,
-0.0071759825,
0.020711597,
0.0030119375,
0.014404633,
-0.0075644073,
0.009763286,
-0.015984666,
-0.011165565,
-0.012883851,
-0.02999429,
-0.002906602,
-0.0035089895,
-0.027703242,
0.0074985726,
-0.025320025,
-0.0019980832,
-0.0055498653,
0.008512427,
-0.010046375,
-0.01092856,
-0.020935435,
0.008644097,
0.004921144,
-0.03291735,
-0.038026124,
0.010388716,
-0.020751098,
-0.029757285,
-0.0030135834,
0.0132130245,
0.0050231875,
0.024253504,
0.026544552,
0.020369256,
0.050745387,
-0.03278568,
0.00056947017,
-0.0026432632,
-0.042081542,
-0.022094125,
0.009743536,
0.021804454,
-0.015984666,
-0.0076894932,
0.016893184,
-0.024214003,
-0.011033896,
0.00023577052,
-0.00802525,
-0.007979166,
0.02001375,
0.023739994,
0.013015521,
-0.0021774827,
0.0026514926,
-0.021672783,
-0.029098937,
-0.0054741553,
0.00031271484,
0.012172836,
-0.0062773386,
0.0038743722,
0.0030168751,
-0.0035386153,
0.003492531,
0.010178044,
-0.013285442,
-0.00016983296,
-0.0057967454,
0.020342922,
0.012679763,
-0.0104940515,
-0.008235921,
-0.0024655096,
-0.03278568,
0.0004497333,
-0.030362964,
0.030652637,
0.0034234044,
-0.0077355774,
0.011567157,
-0.014839142,
-0.017801704,
0.001975041,
-0.009967374,
0.006721723,
0.025728201,
0.017077522,
0.013081355,
0.015286817,
0.0054346547,
-0.0070508965,
0.022265296,
0.003229192,
-0.012581011,
-0.011632992,
0.036130086,
-0.014957644,
-0.0027634115,
-0.014562636,
-0.036867432,
-0.015734494,
0.0061654197,
0.008400508,
0.024108667,
-0.00081552734,
0.0008657263,
-0.029362276,
-0.010099043,
-0.016327007,
-0.037236106,
0.00457222,
-0.024740681,
0.025425361,
0.02754524,
0.029599281,
-0.00091016473,
0.02986262,
0.018381048,
0.008677013,
0.015365819,
0.017248692,
0.03170599,
-0.016682513,
0.026623553,
0.01910523,
0.0011726806,
0.014444133,
-0.033128023,
0.026649887,
0.017696368,
-0.0074261543,
-0.013153774,
0.015457988,
-0.018065043,
-0.019908413,
0.015681826,
-0.00092909223,
-0.01254151,
-0.023476655,
-0.0027140356,
-0.0059448737,
0.0123703405,
0.007663159,
0.013114273,
0.025109354,
-0.025096187,
0.031100312,
-0.016155835,
0.0008435071,
-0.0034398632,
-0.015339485,
-0.0069258106,
0.009282693,
0.021462113,
-0.0021939415,
-0.0014639992,
0.022739306,
0.0059646238,
-0.0004707181,
0.002223567,
-0.0033131314,
-0.010902227,
-0.012469092,
0.016406007,
-0.009651368,
-0.020843266,
-0.001539709,
-0.012416424,
-0.008216171,
0.018236212,
-0.003143607,
0.01269293,
-0.017459363,
-0.016129501,
0.020356089,
0.005602533,
0.02487235,
-0.021185607,
0.0075644073,
0.016076835,
0.0043549654,
-0.03989583,
-0.028940935,
-0.010158295,
0.003041563,
0.027913913,
0.03007329,
0.0043385066,
-0.010625721,
-0.0106454715,
0.0037295357,
-0.023002645,
-0.028282588,
0.000608971,
-0.0067151394,
-0.008854767,
-0.017920205,
-0.009249776,
0.0026103458,
0.022686638,
-0.023002645,
0.005339194,
-0.006820475,
-0.0081766695,
-0.033233356,
0.037130773,
-0.018512718,
0.008222754,
-0.01961874,
-0.009361695,
0.0017544947,
-0.027466238,
-0.002185712,
-0.014878643,
-0.00046536906,
0.025912538,
0.01669568,
-0.013496114,
0.018394215,
0.0125085935,
0.0037690366,
-0.021672783,
0.0063398816,
0.048902016,
-0.002771641,
-0.015444821,
0.010184628,
-0.0043220483,
0.0029378736,
0.019421237,
0.009006187,
-0.00014092741,
-0.03726244,
-0.016893184,
0.019855745,
0.007123315,
-0.013956957,
-0.00865068,
-0.019829413,
-0.006919227,
-0.058671884,
-0.012449342,
0.002584012,
-0.04921802,
0.00025510948,
-0.002559324,
0.015299984,
0.053984456,
-0.00015646029,
0.021146106,
-0.008301755,
0.045768283,
-0.02822992,
0.0036801598,
0.012989187,
0.006576887,
0.0013101106,
-0.012041166,
-0.012153086,
-0.04242388,
0.024200836,
-0.014167627,
-0.029915288,
-0.029625615,
-0.0015643971,
0.014404633,
0.013667284,
-0.018604886,
0.03033663,
-0.001900977,
0.029836286,
0.0016804307,
-0.017538365,
0.017656866,
-0.009546031,
0.0020161876,
0.0051285233,
-0.020158585,
-0.008624346,
0.0130747715,
-0.028335255,
0.0018071625,
-0.0045656366,
0.00023474186,
-0.025530698,
-0.0047894744,
-0.020579927,
0.008551927,
0.00010024362,
0.01327886,
-0.027176565,
0.019737244,
0.024595844,
-0.02595204,
-0.01975041,
0.0020935435,
-0.005302985,
0.009802787,
-0.011922664,
-0.008163503,
-0.0012492135,
-0.031653326,
-0.031574324,
-0.0031913372,
-0.046373963,
0.02801925,
0.004634763,
-0.020711597,
0.0067250147,
-0.004697306,
-0.05735519,
-0.0049145604,
0.009513115,
0.0026152835,
0.001925665,
0.0048388503,
-0.010336048,
0.0120675005,
-0.007169399,
0.0055959495,
0.0041344194,
0.0009546032,
0.036735762,
-0.014667971,
0.016919518,
0.020263921,
-0.043687906,
-0.018525885,
0.054458465,
-0.0069718948,
0.0008110012,
0.030599969,
-0.012686347,
0.03404971,
0.0039039978,
-0.0052009416,
-0.012390091,
0.017327694,
0.014180794,
-0.024859183,
0.0104348,
0.0014804578,
-0.016419174,
-0.007952832,
0.015510656,
-0.013193274,
0.015510656,
0.0032785682,
-0.012291338,
-0.03404971,
0.011178732,
-0.014944477,
0.016406007,
0.0029263524,
-0.005214108,
0.0054214876,
0.0087691825,
0.006701973,
-0.013351277,
0.003900706,
-0.019276401,
0.015523823,
-0.016116334,
-0.0030234586,
0.007834329,
-0.002498427,
-0.00076368253,
-0.029757285,
0.0125085935,
-0.023121146,
-0.008235921,
-0.025833536,
0.012495426,
0.018473217,
-0.027518906,
0.0005246203,
-0.0052733594,
-0.03781545,
-0.006517635,
0.011948998,
-0.0020951894,
-0.030757973,
-0.002918123,
-0.0142334625,
-0.023015812,
0.004190379,
-0.005911956,
-0.0086309295,
-0.023726827,
0.008446592,
0.19086796,
-0.023358151,
-0.013535614,
-0.0022466092,
-0.0015067917,
-0.007294485,
-0.0073010684,
-0.008657264,
-0.0047532655,
-0.022133626,
0.009434112,
0.02585987,
-0.019473905,
-0.0044142166,
0.008723098,
0.002172545,
-0.021146106,
-0.013423695,
-0.02538586,
0.006451801,
0.0014853955,
-0.0011817329,
0.0009949269,
-0.0007476353,
0.04953403,
-0.0034332797,
-0.028835598,
-0.000054570795,
0.002212046,
0.022791974,
-0.057987206,
0.0022054624,
-0.0061950455,
0.0010846267,
0.013733119,
0.017788537,
-0.017314527,
0.001241807,
0.01267318,
0.0023634657,
-0.012212337,
0.002955978,
-0.015602824,
-0.015852995,
-0.0061818785,
0.015839828,
0.015115648,
-0.025622865,
0.0017577865,
-0.0021313985,
-0.043134898,
0.012903602,
0.0058461213,
0.020461425,
0.0023173816,
-0.0055498653,
0.012633679,
0.029019937,
-0.0026037623,
0.038263127,
-0.02284464,
0.01090881,
-0.030178627,
0.03644609,
-0.009269526,
0.004038959,
-0.008894268,
0.021264609,
0.025148856,
-0.035524406,
-0.007590741,
0.0011990145,
-0.0058428296,
-0.008466342,
-0.029572947,
-0.009901539,
0.032048333,
0.00914444,
0.042186875,
0.014957644,
0.009190524,
-0.0018581845,
-0.0050528133,
-0.0026514926,
0.008505844,
-0.0010500635,
0.026755223,
0.005378695,
-0.008887685,
0.013482947,
0.018539052,
0.008874518,
-0.004410925,
-0.008887685,
0.0043911748,
0.0005233859,
-0.020132251,
-0.022594469,
-0.0005423133,
-0.015497489,
-0.006919227,
0.07315552,
0.030178627,
0.0079133315,
-0.026399715,
0.016669346,
0.0015010312,
0.006642721,
0.006201629,
-0.027123896,
0.0011249505,
-0.015155148,
0.015721327,
0.0005814027,
-0.01794654,
0.0017594324,
-0.0021955874,
-0.017735869,
0.036472425,
-0.0021610241,
0.0025741367,
-0.03244334,
-0.009967374,
0.02693956,
0.011007562,
0.0055827824,
-0.011804162,
-0.0045228438,
0.00882185,
-0.03752578,
0.020132251,
0.007775078,
0.0001780623,
0.027518906,
-0.0029658533,
-0.015457988,
0.0022795266,
-0.030020624,
-0.027992915,
0.022515468,
-0.003380612,
-0.019737244,
0.013864788,
-0.007432738,
0.002024417,
-0.003390487,
0.025030354,
0.025122521,
-0.033970706,
-0.007900164,
0.008914019,
-0.01846005,
-0.02345032,
-0.019737244,
0.019184232,
-0.030204961,
-0.021527948,
-0.034971394,
-0.008110835,
0.029046271,
-0.022963144,
-0.0047269315,
0.021290943,
-0.010441383,
-0.00074557797,
0.007998916,
-0.1636914,
0.027202899,
0.010671805,
-0.015444821,
0.016985353,
0.017406695,
0.0035748242,
0.018776057,
-0.014049125,
0.007491989,
0.044609595,
0.013265693,
-0.032548677,
-0.0123703405,
-0.0027815162,
0.0025790744,
-0.03428671,
0.019631907,
0.01267318,
0.0013718306,
0.0093353605,
-0.0432929,
0.025030354,
-0.004447134,
0.021106604,
0.021896621,
-0.007906748,
-0.02663672,
-0.0032851517,
0.009019354,
-0.003910581,
0.014141294,
0.03412871,
-0.013877955,
0.027729576,
0.021922955,
0.007827746,
0.0024029666,
-0.0028012665,
0.041475862,
0.038315795,
0.010388716,
-0.005454405,
0.0052108164,
-0.01975041,
0.035866745,
0.0053457776,
-0.0044438425,
0.02048776,
-0.009012771,
0.023160648,
-0.013904289,
0.012548094,
0.023476655,
0.029757285,
0.0056354506,
0.006251005,
0.00065793557,
0.001416269,
0.012982603,
-0.0032143793,
-0.0046940143,
0.045083605,
-0.021843953,
0.00023556479,
-0.014944477,
-0.003887539,
0.0075512403,
-0.023555657,
0.012765349,
-0.011619825,
-0.008979853,
0.0014393112,
-0.031231983,
-0.0012031292,
0.034734387,
-0.00770266,
-0.0061028767,
0.023897996,
-0.009355111,
0.018236212,
0.0011224817,
-0.020935435,
-0.016656179,
-0.027650574,
-0.006807308,
-0.0069587277,
0.009783037,
-0.01523415,
0.007840913,
0.01631384,
-0.038315795,
0.0035089895,
-0.03339136,
0.013055021,
0.011909498,
-0.0044405507,
-0.014180794,
-0.021251442,
-0.0069718948,
0.0074722385,
-0.016564012,
-0.013232775,
0.018618053,
0.010724473,
0.0075512403,
-0.015023479,
0.0052108164,
0.02138311,
0.011145815,
-0.011527657,
-0.006349757,
0.015510656,
0.04015917,
0.0019421236,
0.008084501,
0.0068994765,
0.0024786766,
0.021330442,
-0.006112752,
0.0723655,
0.0037591613,
0.008334673,
0.0070377295,
-0.008663847,
-0.010968061,
-0.13714685,
-0.0046183043,
0.01798604,
0.002607054,
0.013522448,
0.015049812,
-0.017801704,
0.009295859,
-0.01364095,
0.017999208,
-0.03710444,
0.008393925,
-0.0059448737,
-0.03570874,
-0.008723098,
0.01738036,
0.017959706,
-0.0130747715,
-0.027966581,
0.024569511,
0.0016203566,
-0.019171065,
-0.00088876847,
-0.012620512,
0.020290256,
0.003365799,
-0.04676897,
0.008150336,
0.016063668,
0.015352652,
-0.010559886,
-0.010763974,
0.023516156,
-0.0048981016,
-0.02069843,
-0.0056255753,
-0.014681138,
-0.023305485,
0.04376691,
0.005131815,
-0.0028917892,
0.0061193355,
-0.0021231691,
-0.009914706,
-0.0064616757,
-0.0075117396,
-0.017999208,
0.011395987,
0.015181482,
-0.005194358,
-0.017801704,
-0.029467613,
-0.027808579,
-0.015010312,
0.010862726,
0.0035879912,
-0.0041837953,
0.027992915,
-0.01678785,
-0.010559886,
0.020843266,
-0.008835017,
0.01493131,
0.017235525,
0.047190312,
0.0034102376,
-0.008835017,
-0.025846703,
0.03936915,
-0.011468405,
0.012594178,
-0.0010451259,
-0.01699852,
-0.008551927,
-0.022041459,
-0.007505156,
-0.04213421,
-0.0049145604,
0.009717202,
-0.027703242,
-0.0112314,
-0.015181482,
0.0037361193,
0.017788537,
0.025978373,
0.0005188597,
0.012982603,
0.0036999101,
0.0336547,
-0.03007329,
-0.0070640636,
0.04073851,
0.0021840662,
-0.015839828,
-0.0058592884,
-0.030152293,
-0.007715827,
-0.007182566,
0.010388716,
0.01411496,
-0.02215996,
-0.008374174,
-0.06304331,
0.0133644445,
-0.036077417,
-0.0067875576,
0.017235525,
-0.025425361,
-0.005566324,
-0.024582677,
0.00084433006,
0.0008212879,
0.008407092,
0.0005056928,
-0.010744223,
0.010197795,
-0.03710444,
-0.020764265,
0.02314748,
-0.022910476,
0.010441383,
0.035682406,
-0.018855058,
-0.022054626,
0.00897327,
0.01587933,
-0.017024854,
0.008979853,
-0.0013010583,
0.021699117,
-0.026017874,
0.01235059,
0.004437259,
-0.037631117,
-0.04110719,
0.011415737,
-0.01798604,
-0.0113630695,
-0.015339485,
0.037157107,
0.024240337,
0.024082333,
-0.0103426315,
-0.040527843,
-0.0022647136,
-0.00046454612,
-0.021238275,
-0.01428613,
-0.045978956,
-0.006053501,
-0.007952832,
-0.007952832,
0.0207906,
0.014154461,
0.013706785,
-0.021620115,
-0.012442758,
0.009783037,
-0.0032324838,
-0.02870393,
-0.03283835,
-0.042924225,
0.024148168,
0.027650574,
0.0046676802,
-0.0019602282,
0.021238275,
-0.02345032,
-0.0369201,
0.0074393214,
0.005977791,
-0.000107084255,
-0.013917455,
0.033496697,
0.0053095687,
0.010105627,
-0.011481572,
0.009447279,
-0.02267347,
0.005800037,
-0.014075459,
0.0052239834,
0.014825975,
-0.0049277274,
-0.01458897,
-0.010421633,
0.026992228,
-0.009420945,
0.010671805,
0.0029510404,
-0.006892893,
0.006580178,
0.008749432,
0.035603408,
0.016432341,
0.013693618,
-0.0091971075,
0.025333192,
0.014970811,
-0.0029510404,
-0.000251612,
0.04276622,
0.0038315796,
0.012436175,
0.012679763,
-0.026584052,
0.0003518042,
0.00819642,
-0.034734387,
-0.046505634,
-0.022028292,
-0.0037822037,
0.015141982,
-0.009980541,
0.004371424,
-0.0041442947,
-0.004670972,
0.014720639,
0.0050001456,
-0.021225108,
0.0025922414,
0.015602824,
0.0153921535,
0.034023374,
-0.011086564,
-0.004358257,
0.008268839,
0.0016952435,
0.03942182,
-0.007998916,
0.023160648,
-0.009322193,
0.01284435,
0.00036620552,
-0.029888954,
-0.0025000728,
-0.026360214,
0.0032538802,
0.003280214,
0.012739015,
-0.03494506,
0.09143123,
0.021290943,
-0.0014969165,
-0.006300381,
-0.015207816,
0.03663043,
0.0063234232,
0.01381212,
-0.02164645,
-0.031521656,
0.030204961,
-0.0016203566,
0.010981228,
-0.024806516,
-0.0052667763,
0.021067105,
-0.010948311,
0.016327007,
0.006945561,
-0.021883454,
0.008788933,
-0.020816933,
-0.0069521447,
0.004782891,
-0.02715023,
0.0059448737,
0.022423299,
0.004993562,
0.011468405,
-0.015010312,
0.0077092433,
-0.034102377,
-0.044267252,
-0.006945561,
-0.008301755,
-0.017920205,
-0.0034596135,
-0.022278463,
-0.0054511135,
0.0008200535,
0.012060917,
0.025451696,
-0.010415049,
-0.032733012,
-0.008578261,
-0.0047697243,
-0.012442758,
-0.0069718948,
-0.002980666
] |
BACKGROUND Cali, Colombia, has a high incidence of interpersonal violence deaths. Various alcohol control policies have been implemented to reduce alcohol-related problems. The objective of this study was to determine whether different alcohol control policies were associated with changes in the incidence rate of homicides. METHODS Ecologic study conducted during 2004-08 using a time-series design. Policies were implemented with variations in hours of restriction of sales and consumption of alcohol. Most restrictive policies prohibited alcohol between 2 a.m. and 10 a.m. for 446 non-consecutive days. Moderately restrictive policies prohibited alcohol between 3 a.m. and 10 a.m. | [
0.005700262,
-0.008535224,
0.010544305,
-0.041368194,
-0.0079217125,
0.004611448,
0.004574368,
0.040154655,
-0.005356426,
-0.019349204,
-0.036594942,
0.0025113514,
0.011299396,
0.0098296655,
-0.017528895,
0.012661256,
0.04120639,
-0.034059994,
0.011966842,
0.010989269,
-0.018567145,
0.03387122,
0.015816458,
0.014346727,
-0.01414447,
0.024702258,
0.0025315771,
-0.0264956,
0.029313708,
-0.007820584,
0.015762523,
-0.013200607,
-0.0077531654,
0.013659054,
-0.031174466,
-0.02481013,
0.020495323,
-0.01911998,
0.000081850674,
0.0071801054,
0.0086835455,
0.0023630299,
0.003251273,
-0.023677493,
0.015088334,
0.031525046,
0.025619155,
0.00955999,
-0.009270089,
0.027304625,
0.02617199,
0.028990097,
-0.017771604,
0.0124657415,
0.015762523,
-0.010962302,
-0.00142338,
0.035138693,
0.014737756,
-0.009195928,
-0.00669469,
-0.0059598247,
-0.028369844,
0.03233407,
-0.016733354,
-0.01693561,
-0.039938916,
0.016962577,
0.01256687,
0.013375896,
0.03505779,
0.025929281,
0.0032849824,
-0.020616679,
0.0077531654,
-0.0036709553,
-0.0063710795,
-0.0021978538,
0.012587096,
0.02048184,
0.024068521,
-0.028208038,
-0.013375896,
0.0264956,
0.011973584,
-0.013308477,
0.013342186,
0.0037215194,
0.0057407133,
0.0006442712,
0.0049687675,
0.0029242916,
0.019578427,
0.009822924,
-0.025362963,
0.014899561,
0.0038765827,
0.02141222,
0.023515688,
0.006522772,
0.011825263,
-0.015560266,
-0.023610074,
-0.011737619,
-0.020144746,
-0.022356084,
-0.0057676807,
-0.014157954,
0.010733077,
-0.0036776972,
-0.022868467,
0.0202661,
0.01765025,
-0.026859662,
0.0027439464,
0.00041104417,
-0.01578949,
-0.017839022,
0.020131262,
-0.022571824,
0.0022652727,
0.01346354,
0.010827464,
-0.0046249316,
-0.003933889,
-0.016099617,
0.0005043771,
0.00012325005,
0.0010542619,
-0.018917723,
-0.020899838,
0.01797386,
-0.007335169,
0.015088334,
-0.026050635,
0.013375896,
-0.028666487,
-0.019052561,
-0.009897084,
-0.023542656,
0.0011233663,
-0.0041294033,
-0.014346727,
-0.0016045681,
0.0038327605,
0.027304625,
0.005821616,
0.0405322,
-0.008211614,
0.011602781,
0.0058081322,
-0.015560266,
0.0050328155,
0.0033524013,
0.002066387,
0.006216016,
-0.020131262,
0.029799122,
-0.012917448,
-0.024230327,
-0.006280064,
-0.029421577,
-0.009465603,
0.020131262,
0.026252892,
0.013652313,
0.0066036745,
0.008454321,
-0.0004630831,
-0.0064149015,
-0.0032563293,
0.014306275,
-0.019511009,
0.007995873,
0.012863512,
0.021857185,
0.017488444,
0.0145355,
-0.028477713,
-0.023583107,
-0.022747112,
0.019093012,
0.026954047,
0.033170063,
-0.01357141,
-0.012728675,
0.022868467,
-0.002964743,
-0.008211614,
-0.011730876,
-0.0063710795,
0.010085857,
-0.0038327605,
0.006691319,
-0.65757626,
-0.029637318,
-0.018351406,
-0.02764172,
0.016611999,
0.0075913602,
0.039183825,
0.01851321,
-0.020185197,
0.027938362,
0.01414447,
0.04055917,
0.006114888,
-0.030095765,
-0.018297471,
-0.024998901,
-0.01529059,
-0.007470006,
0.0016416485,
0.010989269,
-0.0052721524,
0.01786599,
0.011272429,
0.016194003,
0.006428385,
0.012823061,
0.022922402,
-0.01747496,
0.0018843563,
0.016086133,
0.00077405246,
0.01650413,
0.007038526,
0.015384977,
0.056523945,
-0.023178594,
0.0049957354,
0.003633875,
0.0343027,
0.027318109,
-0.009566732,
-0.0055957627,
0.02893616,
-0.012310678,
0.0039001792,
-0.008184646,
0.0131466715,
-0.023677493,
0.019093012,
-0.0076790047,
0.029205836,
0.0095330225,
-0.016517613,
-0.017555863,
0.0096611185,
-0.024392132,
0.0043957075,
-0.035354435,
-0.000045692057,
-0.015560266,
0.006681206,
-0.01697606,
-0.023623558,
0.0062362417,
-0.023407817,
0.012910706,
-0.00970157,
0.013584894,
-0.00805655,
0.010544305,
-0.0020781853,
0.015304075,
-0.03187562,
-0.028558616,
0.017501928,
-0.006118259,
0.03254981,
0.0018000827,
-0.02005036,
-0.021209965,
-0.013699506,
0.009425152,
-0.04153,
0.004496836,
-0.002002339,
-0.02005036,
-0.011953359,
0.008373419,
0.008117227,
0.013072511,
0.024985418,
0.0021927974,
0.021951571,
-0.0039204047,
-0.009694828,
0.038266927,
-0.014373695,
-0.003735003,
-0.0071801054,
-0.007031784,
-0.02574051,
0.0040013073,
0.012405065,
0.014495049,
0.011623006,
0.01944359,
-0.009971245,
-0.013942214,
0.035435338,
-0.010274629,
0.0024624728,
-0.0016820998,
-0.002352917,
0.015358009,
0.016099617,
-0.026266376,
0.003852986,
0.0094925715,
-0.0025871976,
-0.00018024002,
0.025147224,
0.0014419202,
0.011838746,
-0.019214366,
0.0059699374,
0.021533575,
0.008029583,
-0.014562467,
-0.014157954,
-0.036945518,
0.010106082,
0.021344801,
0.039858013,
0.0096611185,
0.03384425,
-0.0074430387,
0.018391857,
-0.010746561,
-0.007240782,
-0.008966704,
-0.028828291,
-0.01574904,
0.0024473034,
-0.0018118811,
-0.0038732118,
-0.030823888,
-0.012115164,
-0.0015936126,
-0.020967256,
-0.0010281372,
0.023205562,
-0.019416623,
-0.009951019,
-0.0043282886,
-0.017663734,
0.00032382106,
-0.0073553943,
-0.006691319,
0.0074093295,
-0.006971107,
0.011838746,
0.02130435,
-0.0029023807,
0.002015823,
0.007308201,
-0.019753717,
0.020306552,
-0.004776624,
-0.011022978,
-0.022099892,
0.0059058894,
-0.011144333,
-0.0063171443,
0.022248214,
0.007099203,
0.018324438,
-0.032873422,
0.00819813,
-0.018310955,
-0.00887906,
-0.012067971,
-0.019524492,
-0.01940314,
0.010267887,
0.030877823,
0.017569346,
0.00056758226,
0.0031282336,
-0.02348872,
0.024014587,
0.028558616,
0.018499726,
-0.0073891035,
0.0108072385,
-0.017704185,
0.02982609,
-0.011575813,
0.008899285,
0.017609797,
0.025470834,
0.037377,
-0.0034417312,
0.0077261976,
0.0014764724,
0.0021742573,
-0.0042507574,
-0.013760183,
-0.041233357,
0.028639518,
0.003343974,
0.024082005,
-0.0016989545,
-0.01338938,
-0.0031720558,
-0.025632638,
0.024297746,
-0.024864065,
0.019200882,
-0.010416209,
0.010375758,
0.012270227,
0.0120410025,
0.03263071,
0.00062783784,
-0.006216016,
-0.020778483,
-0.017286187,
0.019578427,
0.012108422,
-0.013847828,
-0.010375758,
0.0113600725,
0.0040619844,
0.026441665,
0.0171109,
0.00680256,
-0.0020579598,
-0.011501652,
0.0148860775,
0.020279584,
0.0014124245,
0.032954324,
0.020320036,
0.005181137,
0.013578152,
-0.010524079,
0.021600993,
0.0035866818,
0.00045676256,
0.028801324,
0.002445618,
-0.014360211,
-0.0014528758,
-0.014050084,
0.010658917,
-0.01392873,
-0.0062362417,
0.008980188,
0.02677876,
0.036406167,
0.02108861,
0.0041091777,
-0.00089245674,
-0.027021466,
-0.031390205,
-0.01231742,
-0.02402807,
-0.02201899,
0.002069758,
-0.013200607,
-0.0060103885,
-0.025403414,
0.021115577,
-0.0015464193,
0.034248766,
0.019093012,
0.017636765,
-0.0027085515,
0.013632087,
-0.0030540728,
-0.01797386,
-0.015695103,
0.0033507159,
0.03573198,
0.004938429,
-0.0045945933,
-0.0076857465,
-0.021681895,
-0.02201899,
0.008245323,
0.011575813,
0.013085995,
-0.015128785,
-0.0028905822,
0.008373419,
0.0037114066,
0.027412497,
-0.0264956,
0.0013138244,
0.006276693,
-0.0011334791,
0.008016099,
-0.010524079,
-0.0028012523,
0.034815084,
0.013038802,
0.018944692,
-0.028127136,
-0.0019349204,
-0.012580354,
-0.0030153072,
0.029044032,
-0.016167035,
0.009108284,
-0.000066418084,
0.010079115,
-0.00019119559,
-0.0049856226,
0.03198349,
-0.02574051,
0.0038900664,
-0.027291141,
-0.018540177,
-0.040127687,
0.076102376,
-0.008757706,
0.008103743,
0.022261698,
0.02069758,
-0.014319759,
-0.013375896,
-0.025969733,
0.00340128,
0.015331042,
-0.014009633,
0.006044098,
0.0099173095,
-0.020765,
0.017623281,
0.011467943,
0.0061317426,
-0.038212992,
0.014710789,
0.013665796,
0.017919924,
-0.023259496,
0.006222758,
0.029906992,
-0.011865714,
-0.025497802,
0.021533575,
0.031552013,
-0.0069778487,
-0.013092737,
-0.024122458,
0.01475124,
0.0007820584,
0.017056964,
-0.011414008,
0.003347345,
0.0073958454,
-0.01775812,
0.008076776,
0.01185223,
0.04905394,
0.006923914,
-0.014522016,
0.00041146553,
0.01285677,
-0.01700303,
0.018351406,
0.036648877,
0.0057272296,
-0.0075576506,
0.005922744,
0.0048710103,
-0.020630162,
-0.015735555,
-0.0019939118,
-0.009465603,
-0.004375482,
-0.00029938173,
-0.020495323,
0.008346451,
-0.019187398,
-0.016665934,
0.033682447,
-0.00041778607,
-0.0041226614,
-0.012357871,
-0.03494992,
-0.01049037,
-0.01836489,
-0.009755504,
0.0010365645,
-0.029799122,
-0.03079692,
0.03058118,
0.0071463957,
0.010571272,
0.031012662,
0.006964365,
0.001286857,
0.0015084964,
-0.03465328,
0.0016787288,
-0.016625483,
-0.014211889,
-0.010685884,
0.016706387,
-0.012094938,
-0.008029583,
-0.0067722215,
0.0038327605,
-0.016598515,
-0.0040552425,
0.028154103,
-0.019187398,
-0.02216731,
-0.004887865,
-0.0046923505,
0.027129337,
-0.007207073,
-0.0059665665,
0.017879473,
-0.003933889,
-0.04039736,
-0.030958727,
0.012775868,
-0.023664009,
-0.011326363,
0.005238443,
0.011724134,
0.004028275,
0.021290867,
-0.033709414,
0.03168685,
0.004075468,
0.023299947,
0.03157898,
-0.0026849548,
0.016126584,
0.016234454,
-0.013699506,
-0.0076790047,
0.010773529,
-0.0069373976,
0.025929281,
-0.017380575,
0.007544167,
0.0106386915,
-0.03190259,
-0.012654514,
-0.000009046237,
-0.005295749,
0.015034399,
0.0028990097,
-0.02173583,
-0.032927357,
0.0048170756,
0.0007218028,
0.02298982,
-0.023246013,
-0.033412773,
-0.011569071,
-0.028450746,
-0.012115164,
-0.041152455,
0.015735555,
-0.026091088,
0.011879197,
0.017380575,
-0.01378715,
-0.010726335,
-0.003461957,
-0.0052721524,
-0.017367091,
0.012876997,
-0.024918,
-0.034707215,
-0.011832004,
-0.012802836,
0.040936712,
0.016194003,
0.035866816,
-0.0025518027,
-0.0002852659,
0.0032377893,
0.012796094,
0.0031669994,
-0.00012251265,
0.009964503,
-0.02130435,
0.018135665,
0.021358285,
0.0023731429,
0.002760801,
-0.010699368,
0.011832004,
0.0047631403,
-0.0065935613,
-0.017124383,
-0.01095556,
-0.014913045,
-0.009391443,
0.0018995255,
-0.010915108,
0.006799189,
-0.0363792,
-0.010753303,
0.021358285,
-0.00031644714,
0.0039878236,
0.0015514758,
0.011751102,
-0.0019821136,
-0.003913663,
0.004641786,
-0.014184922,
-0.0092363795,
-0.02005036,
-0.030365441,
0.008029583,
0.034922954,
0.012411807,
0.021048158,
-0.009101542,
-0.013470282,
-0.0156142,
0.0244191,
-0.0053699096,
0.015047883,
-0.0075171995,
-0.0075239413,
-0.0024675291,
-0.007834068,
-0.010692626,
-0.0013525903,
-0.014063568,
0.014805174,
-0.0023664008,
0.020171713,
-0.005005848,
-0.017461477,
0.0041732257,
-0.019106496,
0.018418824,
-0.020994224,
0.009499313,
0.011366814,
-0.01600523,
-0.0151827205,
0.018391857,
0.01665245,
0.0071868473,
-0.004776624,
0.011697167,
-0.012519676,
-0.014548983,
0.0011014551,
0.029610349,
-0.014427629,
-0.024473036,
0.023151627,
0.030877823,
0.004712576,
-0.018445792,
0.0085149985,
-0.02112906,
-0.019052561,
0.013793892,
0.010766787,
0.039210793,
-0.02223473,
-0.012991608,
0.025807928,
-0.02359659,
0.011919649,
0.015708588,
-0.022868467,
-0.004149629,
-0.0049586548,
-0.020495323,
0.01879637,
0.007982389,
0.018122181,
-0.022895435,
0.010456661,
0.0035226338,
-0.012128647,
-0.0007989131,
0.00094302086,
-0.010854431,
0.028990097,
-0.007982389,
-0.024405615,
0.0013955698,
0.006930656,
-0.0005220746,
-0.0044226754,
-0.008528482,
-0.056793623,
-0.014845626,
0.001111568,
0.025147224,
0.020940289,
-0.008831867,
-0.0027490028,
-0.004881123,
-0.018648049,
-0.026913596,
-0.019268302,
0.011798295,
0.005073267,
-0.013261284,
-0.009013898,
0.00017760647,
0.013982665,
0.016625483,
0.004736173,
-0.0055081183,
0.027318109,
-0.04446946,
0.013625345,
-0.00086001144,
0.01944359,
-0.022410018,
0.016841223,
-0.043768305,
-0.0142927915,
0.026239408,
0.007099203,
-0.04479307,
-0.027884427,
-0.019969458,
0.029367642,
0.004678867,
-0.0032563293,
0.007840809,
0.006671093,
0.0072812336,
-0.01667942,
-0.021156028,
0.023475237,
-0.03597469,
-0.0021253787,
0.020684097,
-0.012391581,
0.024553938,
-0.02251789,
0.033385806,
-0.0056092464,
-0.0092363795,
0.013193865,
-0.020845901,
0.03198349,
-0.004068726,
0.011440976,
0.014575951,
-0.009108284,
-0.010052147,
0.012796094,
0.001983799,
-0.0034231911,
0.021506606,
-0.0039406307,
-0.020738032,
-0.0014958553,
0.00980944,
-0.0244191,
0.0076790047,
-0.003229362,
-0.032576777,
-0.0054373285,
-0.01138704,
0.026724825,
0.019713266,
0.002324264,
0.00040893734,
0.00331195,
-0.052182175,
-0.002728777,
-0.011272429,
0.0049182037,
0.009519539,
0.007254266,
0.009782472,
0.02162796,
0.0056159883,
0.02145267,
-0.026306827,
-0.0029462029,
0.017232252,
-0.0244191,
0.031120531,
-0.010497112,
-0.016895158,
-0.002137177,
0.00082840887,
0.007820584,
0.006630642,
0.04271657,
-0.0073553943,
-0.009000414,
0.005851954,
-0.009249863,
-0.0032849824,
-0.0118724555,
-0.012539902,
-0.020400938,
0.0032023943,
0.013294993,
0.011730876,
-0.003251273,
0.01725922,
-0.009539764,
-0.00022374623,
-0.011926391,
-0.015964778,
-0.040073752,
0.0145894345,
-0.020886354,
0.0022652727,
0.02048184,
-0.0032529584,
0.02474271,
0.011690425,
-0.001254833,
-0.010018438,
0.01790644,
-0.02893616,
0.010416209,
-0.008508257,
-0.015533298,
0.014629886,
-0.022032473,
-0.0017115956,
0.0071194284,
-0.0018877272,
-0.016355809,
-0.020036876,
-0.007982389,
0.037511837,
0.0061991615,
-0.012148873,
0.00033056294,
0.013436573,
-0.01092185,
-0.0046283025,
-0.031174466,
0.011596039,
-0.018472759,
0.021749314,
0.0055991337,
-0.0035597142,
0.01639626,
0.014157954,
-0.008568933,
-0.015910843,
0.024621356,
0.1819769,
0.00095903286,
-0.0064351275,
0.004550771,
-0.041745737,
0.0061418554,
0.009782472,
-0.005811503,
0.0005692677,
0.031740785,
-0.016598515,
0.008757706,
-0.0050328155,
0.014104019,
0.006735141,
-0.003964227,
-0.03597469,
-0.03311613,
-0.009324024,
0.010402725,
-0.009256605,
-0.015870392,
-0.031552013,
0.004887865,
0.034545407,
0.032711618,
-0.019915523,
0.014387178,
0.017663734,
0.012014035,
-0.01961888,
-0.018715467,
0.019888554,
0.00046055487,
0.0034922953,
-0.0019955973,
-0.021034675,
-0.024702258,
0.011447717,
-0.014279308,
-0.0073553943,
-0.004210306,
0.0120410025,
-0.022976337,
0.008811641,
0.00020773427,
-0.0075846184,
0.007368878,
-0.008649835,
0.000050564122,
-0.03608256,
-0.017447993,
0.003060815,
0.022140343,
0.008447579,
0.0045608836,
0.021236932,
0.013719732,
-0.0156142,
0.012216291,
0.02245047,
-0.003519263,
-0.0045844805,
-0.006401418,
-0.015115301,
0.0043417728,
-0.01264103,
-0.016261421,
-0.0036776972,
-0.03079692,
0.022369567,
-0.010618466,
-0.021965055,
-0.0040181624,
-0.007955422,
-0.012485967,
0.03683765,
0.046707764,
0.0161131,
0.028531648,
0.0071126865,
-0.007840809,
0.011690425,
0.0056665526,
-0.021385252,
-0.024162909,
0.008029583,
0.024216844,
-0.025443867,
-0.005460925,
-0.0027877686,
-0.0014790006,
-0.010274629,
-0.012236518,
0.0016104673,
-0.015964778,
0.014481564,
0.011987068,
-0.00966786,
-0.014805174,
-0.028585583,
0.05477106,
0.022423502,
0.000625731,
-0.0094521195,
0.020441389,
-0.010989269,
0.010652175,
0.009357734,
-0.009600441,
-0.005235072,
-0.031417176,
0.006286806,
-0.024783162,
0.013335444,
-0.000067313485,
0.0228415,
-0.037808478,
0.010112824,
-0.00605084,
-0.007335169,
-0.005181137,
0.0065497393,
0.024729226,
0.013659054,
0.0001683364,
-0.01299835,
-0.0026546165,
-0.015223172,
-0.0343027,
0.012216291,
-0.010692626,
-0.00848803,
-0.011629748,
-0.005238443,
0.0061823064,
0.024446068,
-0.014090535,
0.010281372,
-0.005053041,
-0.009937535,
0.010227436,
0.0012160671,
-0.0071531376,
0.009586957,
-0.009404927,
-0.008070034,
-0.008872318,
-0.022828016,
-0.019794168,
0.007429555,
-0.01070611,
-0.012863512,
-0.019146947,
0.010948818,
-0.021614477,
-0.0068902043,
-0.043849207,
-0.0015211373,
0.040586136,
-0.01961888,
0.015951294,
0.030068798,
0.0039001792,
-0.009270089,
0.0139961485,
-0.17205285,
0.019794168,
0.0118724555,
-0.022868467,
0.024338197,
0.006125001,
0.01013305,
0.008818382,
-0.028261973,
-0.0006143541,
0.017933408,
0.016274905,
-0.023893233,
-0.014872594,
0.014575951,
-0.006526143,
0.00966786,
0.019322237,
0.008279032,
0.014198406,
0.036945518,
-0.016922126,
0.012742159,
-0.014157954,
-0.017164834,
0.011326363,
-0.019430107,
0.032307103,
0.004544029,
-0.010436434,
-0.0353005,
0.0038698409,
0.012499451,
0.0037788253,
-0.020576227,
-0.008299258,
-0.020414421,
-0.01879637,
0.0059395987,
0.022935886,
0.030284539,
0.03354761,
-0.013342186,
0.02893616,
-0.010395983,
0.04206935,
0.03025757,
-0.0063407407,
0.0059126313,
-0.006111517,
0.0071598794,
-0.026913596,
0.010301597,
0.007665521,
0.0029040661,
-0.0025686573,
-0.011906166,
-0.019578427,
-0.0016669305,
-0.0030321619,
-0.016895158,
-0.011562329,
0.0082183555,
0.008123969,
0.008926253,
-0.030230602,
-0.019389655,
0.024068521,
-0.0027372045,
0.013874795,
-0.026414698,
0.006900317,
-0.009276831,
-0.023016788,
0.02387975,
0.010456661,
-0.012694965,
0.0061924197,
0.013133188,
-0.010733077,
0.0024405615,
0.0120814545,
-0.024392132,
-0.008427354,
0.0012421919,
0.011205009,
-0.0008132396,
0.024729226,
-0.0044597555,
-0.017690701,
0.028396811,
-0.01747496,
0.021803249,
-0.01693561,
-0.012250002,
0.0053395713,
0.008885802,
0.0008330439,
0.0036507295,
-0.013348928,
0.010335307,
-0.009499313,
-0.022275181,
0.006856495,
0.013807376,
-0.002069758,
-0.011393782,
-0.009951019,
0.0156142,
-0.014656854,
-0.004196822,
0.01940314,
-0.0054272157,
-0.0024253924,
0.0010744876,
0.024540454,
0.030068798,
-0.006681206,
-0.0023748283,
-0.0060171303,
0.034356635,
-0.013220833,
-0.010119567,
-0.019052561,
-0.01729967,
-0.0264956,
-0.1216775,
-0.00006599671,
0.0046990924,
-0.015317558,
-0.0007989131,
0.044253718,
-0.008326225,
0.0117848115,
-0.015250139,
0.01220955,
-0.012067971,
0.005990163,
-0.007078977,
-0.0148860775,
0.05210127,
0.0016526041,
0.0064688367,
-0.02509329,
0.008252065,
0.028639518,
-0.013699506,
-0.0054373285,
-0.0092363795,
-0.0048069623,
-0.0120814545,
-0.0013433201,
-0.0119129075,
0.02309769,
0.0023647153,
0.032064397,
-0.01149491,
0.009870117,
0.0000396349,
0.0019635735,
-0.025511285,
-0.01994249,
-0.015991746,
-0.004648528,
0.0145355,
-0.027291141,
0.014211889,
0.012850028,
0.02294937,
-0.010267887,
0.0099173095,
-0.020117778,
-0.024459552,
0.002277071,
0.0032546439,
-0.007834068,
-0.024931483,
-0.032468908,
-0.014724272,
-0.015776007,
0.009694828,
-0.0011419064,
0.010011696,
0.01142075,
-0.031390205,
0.031956524,
-0.02130435,
0.014454597,
-0.010449919,
0.0156142,
0.020077327,
-0.030716019,
-0.039129887,
0.0069845906,
-0.0035967946,
-0.020036876,
-0.04533242,
0.007436297,
-0.016585032,
0.01622097,
-0.032091364,
0.014130986,
-0.0064755785,
0.009040865,
0.011825263,
-0.010571272,
-0.008993672,
-0.005423845,
0.0023259495,
-0.0037046648,
-0.0021489752,
0.005346313,
-0.0026967532,
0.023030272,
-0.0029765414,
-0.008036325,
0.016854707,
0.03670281,
0.02052229,
-0.027291141,
0.0066474965,
0.01823005,
-0.017232252,
-0.00011692953,
0.019699782,
0.018068247,
-0.026576502,
-0.008454321,
-0.054878928,
0.018526694,
0.0113600725,
-0.0026377616,
-0.0234213,
-0.0011730876,
0.019969458,
0.014346727,
-0.0032209347,
-0.004668754,
-0.003079355,
0.008097001,
-0.034329668,
-0.022571824,
-0.030877823,
0.0053732805,
0.01152862,
0.022760596,
0.02277408,
0.0022838127,
-0.0074632643,
0.0046249316,
-0.007031784,
0.015722072,
-0.0066137873,
-0.009998213,
0.01686819,
0.031363238,
0.007031784,
-0.02223473,
0.0156142,
-0.021951571,
-0.0041799676,
0.0011444347,
-0.0117848115,
-0.02538993,
-0.0029832833,
0.014980464,
0.03648707,
0.015236655,
-0.017421026,
-0.0042541283,
0.006728399,
-0.021654928,
0.012843287,
0.010112824,
-0.016477162,
0.013510733,
-0.00090931146,
-0.012391581,
0.009924051,
0.0008983559,
-0.0154793635,
-0.022976337,
-0.009168961,
0.010712852,
-0.011858972,
0.010470144,
-0.029017065,
-0.044631265,
0.0145894345,
0.0145894345,
0.017946891,
-0.014670338,
0.004490094,
-0.020791966,
-0.01152862,
-0.0025720284,
0.0096206665,
-0.012526418,
-0.0218437,
-0.012438774,
0.0026765275,
0.009526281,
-0.025794445,
-0.010544305,
0.013578152,
0.045278486,
0.00097420206,
0.012978124,
0.009081316,
-0.014993948,
-0.012937673,
0.009634151,
0.037377,
0.026360761,
-0.0080902595,
0.016355809,
0.005639585,
0.0003962963,
-0.020400938,
0.0011823577,
-0.019699782,
-0.017286187,
-0.0019955973,
0.03335884,
-0.002245047,
-0.02660347,
0.030527245,
0.0066778352,
-0.0035765688,
-0.0054440703,
-0.015317558,
-0.01446808,
-0.019200882,
-0.0022467326,
-0.006259838,
-0.034491472,
-0.0053901356,
0.01285677,
0.029475512,
0.0060407273,
-0.0038765827,
-0.0059564537,
0.00723404,
0.017178318,
0.0012270227,
-0.008899285,
-0.011178042,
0.035381403,
-0.01797386,
0.020845901,
-0.004540658,
-0.015776007,
0.013045544,
-0.0048575266,
0.014993948,
-0.0056058755,
0.019902037,
-0.023043755,
0.015209688,
-0.0016576605,
-0.0416109,
-0.005875551,
0.0068733497,
-0.005851954,
0.020131262,
-0.0016045681,
0.0015497904,
0.04139516,
0.0050934926,
-0.0061856774,
-0.0029377756,
-0.00010212899,
0.02893616,
-0.0024321342,
0.013942214,
-0.02567309,
-0.03934563,
0.021142544,
0.0097487625,
0.00787452,
-0.07054706,
-0.0056362143,
0.013888279,
-0.019537976,
0.015910843,
0.021331318,
-0.0026832693,
0.03494992,
0.010146534,
-0.0037282612,
0.012027519,
-0.025727024,
-0.0139961485,
0.008393644,
0.00443953,
-0.014791691,
-0.021924604,
-0.01632884,
-0.0015936126,
-0.013746699,
-0.03090479,
0.022585308,
-0.0048608975,
-0.011440976,
0.01095556,
0.00043190186,
0.02015823,
0.011805037,
0.0017090673,
-0.021708863,
-0.02141222,
-0.01693561,
-0.021493122,
-0.0036642135,
-0.01070611,
-0.010888141
] |
Maltose metabolism of baker's yeast (Saccharomyces cerevisiae) in lean dough is negatively influenced by glucose repression, thereby delaying the dough fermentation. To improve maltose metabolism and leavening ability, it is necessary to alleviate glucose repression. The Snf1 protein kinase is well known to be essential for the response to glucose repression and required for transcription of glucose-repressed genes including the maltose-utilization genes (MAL). In this study, the SNF1 overexpression and deletion industrial baker's yeast strains were constructed and characterized in terms of maltose utilization, growth and fermentation characteristics, mRNA levels of MAL genes ( | [
-0.02760222,
-0.037920423,
0.010201418,
-0.027588481,
-0.025280282,
0.002811401,
-0.003335211,
-0.012640141,
-0.03547483,
-0.0218592,
0.022353815,
0.019441087,
0.021886678,
0.008504616,
-0.016198615,
0.0032630798,
0.030748516,
-0.011094471,
-0.01687184,
-0.00044094512,
-0.015800176,
0.009102276,
0.012200484,
-0.016954275,
-0.010050286,
0.030721037,
0.0018067157,
-0.038799737,
-0.03412838,
-0.00096776074,
0.012770664,
-0.010641075,
-0.009322104,
0.004448093,
-0.001307808,
-0.03566718,
-0.008511486,
-0.022202682,
0.01860299,
-0.025568806,
0.016734447,
0.0075978236,
-0.010668553,
0.012358486,
-0.0049358374,
0.012159266,
0.007927567,
-0.0011944589,
0.010799076,
0.010854034,
0.00011828664,
0.013361453,
-0.014137723,
0.011802045,
-0.025266541,
-0.009150363,
0.015594087,
0.00206261,
-0.01783359,
-0.016995493,
-0.014604858,
0.008800011,
-0.032699496,
0.014343812,
0.013718675,
0.010057155,
0.0063200705,
-0.016143657,
-0.009514454,
-0.015099472,
0.030198945,
0.0004211949,
0.012784403,
0.006745988,
0.029786766,
-0.024414707,
-0.03030886,
0.0024610492,
0.013979721,
0.0035893878,
0.026324468,
-0.011163168,
-0.02778083,
0.013519455,
-0.0034176467,
0.005784238,
0.0023837658,
0.024634534,
-0.004142394,
-0.007130688,
0.008147395,
0.028467795,
0.03797538,
0.020306662,
-0.024840625,
0.015236865,
-0.010792207,
0.04759288,
0.021927897,
-0.006993295,
-0.013622499,
0.011080732,
-0.00978237,
-0.027588481,
-0.014439987,
-0.0118638715,
0.00044352125,
-0.021364586,
0.009693065,
-0.01055864,
-0.015236865,
0.04160255,
-0.014453726,
-0.031298086,
0.004022175,
0.004235134,
0.023425478,
-0.0033867334,
0.0035928227,
-0.038607385,
0.037837986,
0.0067047705,
0.013203451,
-0.02511541,
0.021584414,
0.02052649,
0.009576281,
-0.0022463729,
-0.025816113,
-0.023617828,
0.019853264,
0.011382996,
0.0371785,
0.004953012,
-0.021048581,
0.0079069575,
-0.010036547,
-0.0203204,
-0.009617498,
-0.023301825,
0.012248571,
0.026406903,
-0.033386458,
0.0022137421,
0.0031531656,
0.015278083,
0.0066841613,
0.010599857,
-0.0052037537,
-0.009486975,
0.0008204928,
-0.020169267,
0.0009926632,
0.0049220985,
0.037151024,
0.011183777,
-0.019784568,
0.012248571,
-0.039404266,
-0.01150665,
0.0053033633,
-0.011850132,
-0.0018049984,
-0.0049598813,
-0.017682457,
0.029951638,
0.007838261,
-0.020389097,
0.003184079,
-0.02187294,
0.012818751,
0.012605793,
-0.027107606,
0.029786766,
-0.013485107,
0.021392064,
-0.00709634,
-0.0066120303,
-0.013972851,
-0.0017775198,
-0.015965046,
0.022875907,
0.028247967,
0.021227192,
-0.014288855,
0.0042213947,
0.013471368,
-0.0053033633,
-0.00086643355,
-0.022147724,
-0.013828589,
0.014275115,
-0.0026722907,
-0.010256375,
-0.626951,
-0.034375686,
0.027945703,
0.006962382,
-0.022395032,
0.027327435,
0.020457793,
-0.008085568,
0.028934931,
0.025211586,
-0.0003552893,
0.017160365,
0.006464333,
-0.019042647,
-0.014343812,
-0.016377226,
0.000055923178,
-0.026874037,
0.025005495,
-0.005255276,
-0.039953835,
0.008470268,
-0.004331309,
0.0057979776,
0.027931962,
0.017132886,
0.041300286,
-0.029402066,
-0.003166905,
0.025651243,
-0.02624203,
0.0371785,
-0.010325071,
0.0036409101,
0.045202244,
0.012564574,
-0.022133986,
0.0035756484,
0.04124533,
0.026983952,
-0.015333041,
-0.021721806,
0.017325236,
0.0019784567,
-0.012701968,
0.031957574,
0.010132722,
0.018108375,
0.01475599,
-0.014034678,
-0.009404539,
-0.007336777,
-0.0094594965,
-0.0070482525,
0.039981313,
0.018355682,
0.017160365,
-0.027849527,
0.023686524,
0.011231864,
0.0023477,
0.029951638,
0.001150665,
0.009109145,
-0.029374588,
-0.006807815,
-0.00881375,
-0.0044961805,
0.031298086,
-0.0019509782,
0.022298858,
0.011492911,
0.009535063,
0.0214745,
0.00882062,
0.031545393,
-0.0012768947,
0.009851066,
-0.023823917,
0.0040908717,
0.003026077,
0.004733183,
-0.029759288,
-0.030198945,
0.027588481,
-0.016432183,
-0.014137723,
0.020045614,
-0.015401737,
-0.013739283,
0.00422483,
0.015594087,
-0.014646076,
-0.03607936,
-0.022930864,
0.021062322,
-0.018822819,
0.014508683,
0.030803474,
-0.015387997,
-0.0058494997,
0.0059010223,
0.011589086,
-0.015965046,
-0.0037164763,
0.009651846,
-0.020911189,
0.028412838,
0.03300176,
-0.030721037,
0.0026963344,
-0.008222961,
-0.017778633,
-0.00011098765,
0.0061586336,
-0.0160887,
0.025087932,
-0.0057224114,
-0.00077240536,
-0.024826884,
-0.009892284,
0.008113047,
0.004568312,
0.015841393,
-0.02589855,
0.01783359,
0.010840295,
-0.015745219,
0.0038985217,
-0.0070826006,
-0.009569411,
0.0035413003,
0.03470543,
-0.025266541,
0.014989559,
0.010874643,
0.012385964,
0.0015284952,
-0.00027693243,
-0.031188173,
-0.013121015,
-0.006100242,
-0.011005166,
-0.011211256,
-0.00074492674,
0.013437019,
0.008573313,
-0.0086214,
0.008030611,
0.019248735,
0.016322268,
0.00393287,
-0.017764894,
0.008786271,
-0.011142558,
-0.013402671,
-0.025912289,
-0.033826116,
-0.020732578,
-0.00021789645,
0.014069026,
0.012660749,
-0.010318202,
-0.0051831445,
-0.025568806,
-0.020856231,
0.016143657,
-0.0040668277,
-0.010771598,
-0.003853869,
-0.0074123433,
-0.009006101,
-0.019289954,
0.008394702,
0.015223126,
0.0156078255,
-0.011843262,
0.015415476,
-0.0005654574,
-0.002112415,
0.0062238956,
-0.008841229,
-0.013079798,
0.008071829,
0.023590349,
0.018864036,
-0.0081680035,
-0.003530996,
-0.00085527037,
0.039019566,
-0.02012805,
0.0075016487,
0.009129753,
-0.005612497,
0.010462464,
-0.01709167,
-0.0026980517,
-0.02548637,
-0.020073093,
0.017517587,
0.011870741,
-0.009796109,
0.0014675272,
-0.02857771,
0.015333041,
-0.032424707,
0.009651846,
-0.019468565,
0.011444823,
0.019853264,
0.0011901654,
-0.01341641,
-0.00805809,
0.011005166,
-0.00043321677,
0.00824357,
0.014048417,
-0.0026224856,
-0.015099472,
-0.008030611,
-0.020086832,
-0.02838536,
0.02375522,
-0.0062101563,
-0.023178171,
0.03734337,
-0.015044515,
0.011149429,
-0.005196884,
-0.012722576,
-0.017146626,
0.031875137,
0.0042626127,
0.011712739,
0.005481974,
0.011238734,
0.03544735,
-0.0031411436,
0.045889206,
0.0034863432,
-0.011293691,
0.008971752,
0.0128943175,
-0.010675423,
-0.000035153244,
0.018561771,
0.014824687,
0.024881842,
-0.010476204,
0.011788305,
-0.00055300613,
0.030858431,
-0.011698999,
-0.008030611,
0.010386898,
-0.0069658165,
0.014398769,
0.0033987553,
0.03544735,
0.02107606,
-0.018204551,
0.008140526,
-0.010764728,
-0.020691361,
-0.015580348,
0.013320236,
0.03492526,
-0.0059285006,
0.010771598,
0.0052587106,
-0.042289514,
0.015937569,
0.0010579248,
-0.012674489,
0.005708672,
0.004173307,
0.003661519,
0.0048224884,
0.020828754,
0.0009832175,
-0.01780611,
-0.012015004,
0.032287315,
0.006350984,
0.0032888409,
-0.011657782,
-0.015017036,
0.012015004,
-0.007192515,
-0.0049324026,
-0.00009950247,
0.014439987,
-0.017943503,
-0.014797208,
-0.010750989,
-0.008511486,
0.005045752,
-0.017338976,
0.019976918,
0.006254809,
0.013361453,
0.035200045,
-0.0036168664,
-0.035117608,
0.052676413,
-0.008394702,
-0.014989559,
-0.0028337273,
0.0031291218,
-0.040998023,
0.017201582,
0.024620796,
0.0070310785,
-0.021969113,
-0.010579248,
0.01148604,
-0.004561442,
-0.009514454,
0.010132722,
-0.0029642503,
-0.009150363,
-0.050148383,
0.011602825,
0.0029522285,
0.017902287,
0.05957353,
-0.012001264,
-0.008174874,
-0.003012338,
0.03432073,
-0.0020523055,
-0.019180039,
0.0075016487,
-0.027258739,
-0.010105243,
-0.008353484,
0.009081666,
-0.0013799393,
-0.0026293553,
0.008422181,
0.012969883,
-0.029044844,
-0.0076939985,
0.010345681,
0.014096505,
-0.02970433,
-0.00035314253,
0.035062652,
0.026805341,
0.0074879094,
0.012379094,
0.04270169,
-0.0035893878,
-0.0005105002,
0.0025160064,
0.00958315,
0.004269482,
0.0062994612,
-0.015181908,
-0.0060830675,
0.032287315,
0.002117567,
-0.015319301,
0.028124314,
0.019001428,
-0.0020694796,
0.011829523,
0.018080898,
-0.014020938,
-0.02877006,
-0.011279952,
0.015305562,
0.0012365355,
-0.027712135,
0.025926027,
-0.020018136,
-0.020581447,
0.0043622223,
0.008710706,
-0.015649043,
0.016349748,
0.000519946,
0.0051659704,
-0.0062376345,
-0.018520555,
-0.011190646,
0.022188943,
-0.0073917345,
-0.011630303,
0.008745054,
-0.000024674357,
-0.016033744,
-0.012413442,
-0.0027014867,
0.00937706,
-0.025046714,
-0.024813145,
-0.00012365355,
0.017215323,
0.03434821,
0.000057264904,
-0.033441417,
0.0044206143,
0.0049942294,
-0.029044844,
-0.015236865,
-0.007982523,
-0.031517915,
-0.011657782,
-0.017709937,
0.020691361,
-0.024716971,
-0.012344746,
-0.008408441,
0.0077146078,
-0.0027066388,
0.004255743,
-0.016706968,
-0.009919763,
0.0042282646,
0.029099802,
0.029979117,
-0.0017431716,
-0.021708068,
0.00633381,
-0.0017861068,
-0.029017366,
0.00013374334,
-0.02202407,
-0.018286986,
-0.0088549685,
-0.0009772065,
0.0050491868,
0.025774896,
0.0066566826,
0.0008715858,
0.0020677622,
0.0105449,
0.020457793,
0.031902615,
0.005904457,
0.0103594195,
-0.0058323257,
0.010345681,
0.004654182,
-0.027753353,
0.035145085,
-0.016913058,
-0.022958342,
0.0123378765,
0.008518356,
-0.036189273,
-0.0015611261,
0.008662618,
-0.027478566,
0.035914488,
0.008559573,
-0.026145857,
-0.06270609,
-0.012990492,
-0.016981754,
-0.0019939134,
0.0010433268,
-0.003871043,
-0.037645638,
-0.018067157,
0.0060899374,
-0.029594416,
0.01342328,
-0.038030338,
-0.01303171,
0.0068112495,
0.0067837713,
0.022834688,
-0.0131072765,
0.017957244,
-0.031105738,
-0.007852,
-0.003908826,
-0.019633437,
0.00050878286,
0.008147395,
0.047620356,
0.022079028,
0.04028358,
0.0008660042,
0.0115203895,
0.011176907,
0.003719911,
0.0069726864,
-0.0073505165,
0.011142558,
-0.021021103,
0.01650088,
0.028852494,
0.011115081,
0.04066828,
0.007961915,
0.014137723,
0.020416575,
-0.009383931,
-0.031545393,
-0.012859969,
-0.039184436,
-0.012949275,
0.019125082,
-0.014865905,
-0.010860903,
-0.014467466,
-0.014907123,
0.020444054,
0.021405803,
0.0013490259,
0.009170972,
0.024455924,
-0.018328205,
0.03984392,
0.018493075,
0.0013593304,
-0.0055575403,
-0.023150692,
0.014330072,
-0.017338976,
0.015978787,
0.003166905,
0.010984557,
-0.027849527,
-0.018149594,
-0.024675753,
0.017600022,
-0.008463399,
-0.006271983,
-0.01687184,
-0.039981313,
-0.020746319,
-0.004334744,
-0.034622993,
-0.03682128,
0.024799407,
0.0020488705,
-0.023109475,
0.0176275,
-0.003737085,
0.0022463729,
0.022449989,
-0.00056588673,
0.031408,
-0.001255427,
0.029319631,
0.00067708903,
0.000040976338,
0.0014005481,
-0.0020591752,
0.031600352,
-0.018273247,
0.02819301,
-0.0029350545,
-0.0031772093,
-0.021392064,
0.00901984,
0.0059319357,
-0.00976863,
-0.01765498,
0.024208616,
0.0036855629,
-0.012173005,
-0.017421411,
-0.008353484,
-0.011073862,
-0.0012416877,
-0.00063243636,
0.02202407,
-0.020183008,
-0.017407672,
-0.01589635,
0.021927897,
0.012495878,
0.009988459,
0.020444054,
0.0025675285,
0.007927567,
0.009074797,
-0.018149594,
0.023714002,
-0.016555836,
0.04751044,
-0.0062376345,
0.005694933,
-0.017174104,
0.00748104,
0.0020196748,
-0.0030071856,
-0.01266762,
0.03275445,
0.014522422,
-0.0017320084,
0.00882062,
-0.013148494,
0.020553967,
0.007996263,
-0.00527932,
-0.017943503,
-0.035392392,
0.0008333734,
0.025623763,
0.016968016,
-0.028412838,
0.0007337636,
-0.013395801,
-0.008401572,
-0.010881512,
-0.016390964,
0.0033832986,
-0.025788635,
0.0046954,
-0.0257062,
0.015690261,
0.01552539,
0.0032699495,
0.004413745,
0.0018290421,
0.022161463,
0.0023751785,
0.040146187,
0.0023631568,
-0.0030827518,
-0.007268081,
0.008326006,
-0.03434821,
-0.0129767535,
0.017668718,
0.006694466,
-0.012502748,
0.01283936,
-0.010064025,
0.011094471,
0.021556936,
-0.014783469,
-0.00006671066,
-0.0035516047,
0.030583644,
-0.0006955512,
-0.0050114035,
0.008566443,
-0.022669818,
-0.008374093,
0.014247637,
-0.015442954,
-0.018067157,
0.01802594,
-0.0069383383,
0.00072989945,
-0.016748186,
-0.025046714,
-0.007061992,
0.014549901,
0.016789405,
0.012008133,
0.031957574,
-0.021625632,
-0.0065605077,
0.0063166353,
-0.0040599583,
-0.026709167,
-0.032891843,
-0.023906354,
-0.011417344,
0.01016707,
-0.023590349,
-0.013210321,
-0.013127885,
-0.026695428,
-0.02203781,
-0.011087602,
-0.02202407,
0.0444878,
-0.0060865027,
-0.012063091,
-0.025843592,
-0.003915696,
-0.018548032,
-0.011575346,
-0.009239668,
-0.012956144,
0.0015345062,
0.010826555,
-0.022010332,
-0.012784403,
-0.015704,
0.029099802,
-0.009040449,
-0.005083535,
0.009940372,
0.0032527754,
0.027918223,
-0.00422483,
-0.01972961,
-0.00287151,
0.0176275,
0.0009978154,
0.0030861865,
0.031133216,
0.0016452792,
0.008442789,
-0.012241702,
0.01496208,
0.01994944,
0.007838261,
0.03162783,
-0.005004534,
-0.026008463,
0.0054201474,
-0.00022498076,
0.011170037,
0.0049495767,
-0.009102276,
-0.015676523,
0.017723676,
0.0122073535,
-0.0029642503,
-0.005478539,
-0.006745988,
0.0094594965,
0.021447022,
0.0078245215,
-0.0011893067,
0.014934601,
-0.021392064,
-0.00023335314,
-0.010647944,
-0.013883546,
-0.0053377114,
0.0052243625,
-0.0069726864,
-0.025458893,
0.018067157,
0.00091452105,
0.013684326,
0.004698835,
0.010029677,
-0.019262476,
-0.023823917,
0.0011540998,
-0.011252473,
-0.015470433,
-0.023054518,
0.012784403,
-0.0050182734,
0.011437953,
0.010599857,
0.0036168664,
0.010654815,
-0.021378325,
0.0077352165,
-0.026406903,
-0.0033146022,
-0.0086214,
-0.01879534,
-0.011547867,
0.0023288084,
0.19454825,
-0.008648879,
-0.009301495,
0.035419874,
-0.0022034375,
-0.005674324,
0.0035584744,
-0.008195482,
-0.013979721,
0.006735684,
0.017517587,
0.010785338,
-0.025541328,
-0.013100407,
-0.0043416135,
0.014412508,
-0.028247967,
-0.02626951,
-0.009555671,
-0.019331172,
0.01611618,
-0.013856067,
-0.013299626,
-0.0058391956,
0.028879974,
-0.009837327,
-0.014412508,
0.008875577,
0.022985822,
0.01170587,
-0.01033881,
0.008758794,
-0.010139591,
-0.011479171,
-0.021213453,
-0.008903055,
0.021927897,
-0.017517587,
0.005176275,
0.013519455,
-0.0017792372,
-0.0034004727,
0.01858925,
0.014494944,
-0.017366454,
-0.019138822,
-0.010812816,
0.01130743,
-0.0021656544,
-0.020938668,
-0.044213016,
-0.0074535613,
0.009603759,
0.019331172,
0.030418774,
-0.0176275,
0.035227522,
0.006862772,
-0.0002273422,
0.01552539,
-0.036189273,
-0.00421796,
-0.0464113,
0.010421246,
-0.023068257,
0.014096505,
-0.019028908,
0.004698835,
0.009727413,
-0.008174874,
-0.0054957136,
-0.017764894,
0.008868707,
0.0078039127,
-0.007934436,
0.002674008,
0.025472632,
0.011293691,
0.01626731,
0.018575512,
-0.021982854,
0.01112882,
-0.028247967,
0.0072955596,
0.0009231081,
-0.032672014,
0.010256375,
-0.020279182,
-0.020760057,
-0.019289954,
0.017558804,
0.010895251,
-0.005251841,
-0.020251704,
-0.020224225,
-0.025816113,
0.0222439,
0.0014074178,
0.0074947793,
-0.022326335,
-0.034403164,
0.0479501,
-0.028330402,
0.029044844,
-0.015195647,
-0.017517587,
-0.005323972,
0.0018616728,
-0.0030879038,
-0.0062341997,
0.0036099968,
-0.04042097,
0.005056056,
-0.015965046,
-0.010070895,
0.0013335692,
-0.004485876,
-0.020292921,
0.025005495,
-0.030940866,
0.011850132,
-0.008415311,
0.014426247,
0.01626731,
-0.040915586,
0.010476204,
-0.018396901,
0.008147395,
-0.02051275,
-0.05240163,
0.018300725,
-0.007364256,
-0.0033953204,
0.018657947,
0.012021873,
-0.010826555,
0.003754259,
0.012908056,
0.005427017,
0.012097439,
-0.01819081,
-0.0078039127,
0.00393287,
0.007405474,
-0.022656078,
-0.04261926,
0.017929764,
0.018245768,
-0.022601122,
0.0049667507,
0.000438369,
-0.025596285,
0.011025775,
-0.0344856,
0.0070826006,
-0.015278083,
-0.002406092,
-0.051082656,
-0.0065433336,
0.015360518,
-0.055891406,
0.020183008,
0.0028268576,
-0.0042316993,
0.017380193,
0.009603759,
-0.17465377,
0.019509783,
-0.00038384122,
-0.03028138,
0.028495274,
0.023672786,
0.018493075,
0.010125852,
-0.0023081996,
0.022381293,
0.009225929,
-0.012866839,
-0.03143548,
-0.006213591,
-0.017558804,
0.017792372,
-0.02107606,
0.031545393,
0.010421246,
0.0018651077,
0.02319191,
-0.014618598,
-0.016390964,
-0.01706419,
-0.009631238,
0.023246868,
0.008532095,
-0.0004765814,
-0.03984392,
-0.0150032975,
-0.029457023,
0.008264179,
0.020499012,
-0.010249506,
0.03316663,
-0.015511651,
0.006574247,
0.005406408,
-0.009315234,
0.010064025,
0.02146076,
0.02626951,
0.007831392,
0.008958013,
0.0060384152,
0.030830951,
-0.0036683886,
0.007405474,
0.018149594,
0.013959112,
0.016061222,
0.0037611288,
0.010764728,
0.032644536,
0.007742086,
0.0025589415,
0.010132722,
0.004327874,
-0.0036580842,
-0.014062157,
0.009603759,
-0.022601122,
0.04261926,
0.002691182,
-0.009576281,
-0.024304792,
-0.009074797,
0.0015757241,
-0.018245768,
0.004637008,
-0.00996098,
0.00708947,
0.009713673,
0.021199714,
0.0073161684,
0.00029281847,
0.0024163965,
0.007364256,
-0.018273247,
-0.0025606588,
-0.008566443,
0.022917125,
-0.03278193,
-0.0034176467,
0.027767092,
0.00022412206,
0.012063091,
0.026558034,
-0.0036512145,
0.0062032863,
0.014426247,
-0.0030913388,
-0.00057747925,
-0.01764124,
0.03742581,
0.0054922784,
0.023466695,
0.0071238186,
0.004345048,
0.02740987,
0.0094594965,
-0.02606342,
-0.021405803,
-0.0046850955,
0.034787867,
-0.000586925,
-0.03030886,
0.008800011,
0.03932183,
-0.027093867,
-0.007013904,
-0.002184546,
0.019317433,
0.015374258,
-0.0073573864,
0.028110573,
0.012385964,
-0.023837656,
0.008964882,
-0.019894483,
0.033276543,
0.0073161684,
-0.021570675,
0.00805122,
-0.01765498,
0.0005770499,
-0.13057815,
-0.05215432,
-0.013773631,
-0.0042282646,
-0.014261376,
0.011911958,
-0.0017113995,
0.024373489,
-0.005176275,
0.012557705,
-0.025623763,
-0.019372389,
0.001887434,
-0.0072543416,
0.014783469,
-0.017036712,
0.021364586,
0.008978622,
-0.006423115,
0.023741482,
-0.025582546,
0.014343812,
0.000048355836,
-0.0045923553,
0.0039637834,
0.021034842,
-0.02816553,
0.0132377995,
0.015800176,
0.028247967,
0.03011651,
-0.023810178,
0.006653248,
0.0011824371,
-0.010826555,
0.00059851754,
-0.008669488,
-0.018465597,
0.016171137,
-0.015470433,
-0.010139591,
-0.0022446555,
0.032562103,
-0.011492911,
-0.0073161684,
0.013945373,
-0.019042647,
0.012413442,
0.02473071,
-0.0237827,
-0.017132886,
-0.011204385,
-0.03742581,
-0.024208616,
0.018438118,
-0.024455924,
0.026420642,
0.023906354,
-0.018204551,
0.010009068,
0.016171137,
0.025266541,
0.004022175,
-0.0050526215,
0.00053754944,
-0.008154265,
-0.0029230325,
-0.05314355,
0.007948175,
-0.03530996,
-0.006958947,
0.013299626,
0.00450992,
-0.0214745,
-0.026722906,
0.014879644,
-0.028934931,
-0.019125082,
-0.007900088,
-0.027272478,
-0.021213453,
-0.015937569,
0.026159596,
-0.03127061,
0.031160695,
0.005852935,
0.017160365,
0.012296659,
0.0013868089,
-0.0049358374,
-0.008916795,
0.017751154,
0.010496813,
0.0011188929,
-0.031408,
0.03890965,
-0.037453286,
-0.0068971203,
0.02357661,
-0.0043622223,
-0.019496042,
-0.0058014123,
-0.05677072,
0.001514756,
0.008133655,
0.002121002,
0.011389866,
0.005825456,
-0.009665586,
0.015868872,
-0.019289954,
0.02089745,
-0.024057485,
-0.009006101,
-0.014426247,
-0.0064746374,
-0.02379644,
-0.004643878,
0.05119257,
-0.004235134,
0.03143548,
0.029182239,
-0.014330072,
0.021295888,
-0.011328039,
0.031160695,
-0.03280941,
-0.004832793,
-0.020389097,
0.027835788,
-0.00556441,
-0.015621565,
0.020663882,
-0.035392392,
0.0002481658,
-0.0057739336,
-0.026860299,
-0.012489009,
0.006636074,
0.016212353,
0.02628325,
0.016816882,
-0.008064959,
-0.021172235,
0.0035344306,
-0.0013558955,
-0.004430919,
-0.00017624925,
-0.028825017,
0.019976918,
0.0007457855,
-0.014618598,
0.037233457,
0.004159568,
0.0152643435,
-0.022010332,
-0.000445668,
-0.0030655777,
-0.0046129646,
0.0030982085,
-0.020100571,
-0.033029236,
0.029127281,
0.0056262366,
0.034732908,
-0.0005980882,
0.0008956295,
0.010551769,
-0.009274016,
0.008099307,
0.0061998516,
-0.04404814,
-0.015621565,
0.012482139,
0.031600352,
0.0027169434,
0.02243625,
0.012200484,
-0.010641075,
0.003038099,
-0.006807815,
0.0063715926,
0.028605187,
-0.013636239,
-0.0140552865,
0.018438118,
0.03275445,
-0.008655748,
0.0069314684,
0.029951638,
0.021955375,
0.0018221724,
0.0052655805,
0.0150857335,
0.02626951,
-0.0046129646,
0.03201253,
0.0514124,
-0.003585953,
0.021584414,
0.0022206118,
-0.0071856454,
-0.018548032,
0.014508683,
-0.009899153,
-0.018685425,
-0.0073505165,
0.026695428,
-0.021721806,
-0.011286821,
-0.004671356,
-0.006687596,
0.017352715,
0.010627336,
0.0035086696,
0.0017586283,
-0.0077352165,
-0.0013619064,
-0.004314135,
-0.008353484,
-0.00031063662,
0.0019973484,
0.0073161684,
0.0039363047,
0.008456529,
-0.005694933,
0.024785668,
0.0055163223,
0.025967246,
-0.027382392,
0.002498832,
-0.018520555,
0.022889646,
-0.0029316195,
-0.025637502,
-0.027478566,
-0.005784238,
0.0039397394,
0.012990492,
0.014137723,
-0.009315234,
0.0832051,
0.02992416,
-0.0073299077,
-0.01626731,
0.027354913,
0.013670587,
-0.005427017,
-0.008216091,
-0.0045545725,
-0.024716971,
0.019042647,
-0.019289954,
0.009438887,
-0.029841723,
-0.013100407,
-0.003895087,
-0.0030861865,
0.022532424,
-0.012825621,
-0.009308364,
0.009912893,
-0.0068765115,
0.003192666,
-0.00021864781,
-0.011650912,
-0.022683557,
0.055836447,
0.007721477,
0.0038435645,
-0.032672014,
0.002674008,
0.004472137,
-0.029841723,
-0.012131787,
0.0074260826,
0.010118982,
0.0058598043,
0.014357551,
0.015291822,
0.01938613,
-0.011609694,
-0.019784568,
-0.0059113265,
-0.012928666,
-0.018506814,
-0.0047778357,
0.00021875516,
-0.006247939,
-0.014330072
] |
Ribosomopathies compose a collection of disorders in which genetic abnormalities cause impaired ribosome biogenesis and function, resulting in specific clinical phenotypes. Congenital mutations in RPS19 and other genes encoding ribosomal proteins cause Diamond-Blackfan anemia, a disorder characterized by hypoplastic, macrocytic anemia. Mutations in other genes required for normal ribosome biogenesis have been implicated in other rare congenital syndromes, Schwachman-Diamond syndrome, dyskeratosis congenita, cartilage hair hypoplasia, and Treacher Collins syndrome. In addition, the 5q- syndrome | [
-0.028253103,
-0.0083705485,
0.010118025,
-0.044607352,
-0.039271545,
0.028413177,
-0.0051190406,
-0.0067397924,
-0.019462358,
-0.0024044483,
0.0063729556,
-0.013066059,
-0.0030530826,
-0.0043086647,
-0.00034349263,
0.01663438,
0.023490895,
0.001500696,
0.012619185,
0.012299037,
-0.016460966,
0.01499362,
-0.012345726,
-0.029747128,
0.013699686,
-0.0014681809,
0.030760933,
-0.01778158,
-0.021183157,
0.009604454,
0.022903955,
-0.024291266,
0.01053822,
-0.00079953746,
0.0035416423,
-0.008810753,
0.026465606,
0.002319409,
0.015673935,
-0.0097045,
0.024584735,
0.01918223,
-0.008150446,
0.016981209,
0.002694583,
0.0011063464,
-0.009257627,
0.008724046,
-0.024598073,
-0.018328499,
0.02334416,
0.009651142,
-0.019195568,
-0.008177126,
0.0032498403,
0.00032911095,
-0.010618257,
0.016340911,
-0.008143777,
-0.00029472,
0.013532942,
-0.0024811507,
-0.022250319,
-0.012625855,
-0.010471523,
0.0025211691,
0.026492286,
0.013352859,
-0.00016132482,
0.006969899,
0.0472219,
0.018168425,
-0.015140355,
0.0017291352,
0.017901635,
-0.033962417,
-0.009511078,
-0.005299124,
-0.01137194,
0.006769806,
0.011832153,
0.016020764,
0.0072833775,
0.010464853,
0.008223814,
-0.017874956,
-0.021049762,
0.026198816,
-0.0018025025,
-0.006863183,
0.009404361,
0.025185013,
-0.0014314972,
-0.0007624369,
-0.016220856,
0.0011471987,
0.01778158,
0.032655142,
-0.008590651,
-0.02277056,
0.00036871264,
0.032281637,
-0.02529173,
-0.00072783756,
0.007876987,
-0.002721262,
-0.0057593375,
0.025465142,
-0.002482818,
-0.012312377,
-0.016581023,
0.03193481,
0.01886208,
-0.04188609,
0.024344623,
-0.0009270966,
0.036763716,
0.017541468,
0.01499362,
-0.022023547,
0.015420484,
0.022090245,
0.009030854,
-0.020222712,
0.024051154,
-0.026679039,
-0.046261452,
-0.017794918,
-0.017087925,
-0.016500985,
-0.009017515,
0.005659291,
0.007970363,
-0.003229831,
0.0026278854,
-0.0048122318,
-0.025691915,
-0.016621042,
-0.017368054,
-0.024091173,
0.011978889,
0.03212156,
-0.04185941,
0.006496346,
0.012879306,
0.013306171,
-0.0023777694,
0.004325339,
-0.00693655,
-0.013592971,
0.010611588,
0.011291903,
0.0014073193,
-0.011898851,
0.013066059,
0.026732396,
0.0037083863,
0.02693249,
-0.013766384,
-0.023384178,
-0.00023552589,
0.010564899,
-0.017741561,
0.014806867,
0.00652636,
0.01695453,
-0.00094543846,
-0.013699686,
-0.0039051443,
-0.0058727236,
-0.012799269,
0.0104581835,
-0.030120635,
0.025451804,
0.002539511,
0.005089027,
-0.010978425,
0.017261337,
-0.0322016,
-0.018488575,
0.0016449295,
-0.006889862,
0.037110545,
0.0043086647,
-0.008904129,
0.008170456,
0.039004754,
-0.0017508119,
0.01638093,
-0.008570641,
-0.014886904,
0.021023083,
0.028653288,
-0.025211692,
-0.61724627,
-0.04020531,
0.0010446511,
-0.021503305,
0.013619649,
0.019048834,
0.0069165407,
-0.01606078,
0.0006040301,
0.012712562,
-0.0048755943,
0.017981673,
0.027372694,
-0.030760933,
0.0019075513,
-0.025438463,
0.015780652,
-0.0112118665,
0.01888876,
0.015673935,
-0.01859529,
0.0053091287,
-0.0028113038,
0.0017191306,
-0.0044387253,
-0.0016841143,
0.029773807,
0.0036450238,
0.020369446,
0.015887368,
-0.034042455,
0.033962417,
0.003164801,
-0.0035649866,
0.045140933,
0.0063729556,
-0.0024794831,
0.02361095,
0.02305069,
0.007743591,
-0.0107116345,
0.011438638,
0.036310174,
0.011865502,
-0.010051328,
0.032041527,
0.008230483,
0.01580733,
0.012245679,
-0.017154623,
-0.005505887,
0.009611124,
-0.016914511,
0.008924139,
0.030867647,
-0.0006978236,
0.023090709,
-0.029587055,
0.037884235,
0.0048155664,
-0.0107116345,
0.01835518,
-0.014019835,
-0.011598712,
-0.0030580848,
0.015927386,
-0.023024011,
0.0112518845,
-0.001438167,
-0.021089781,
0.017047906,
0.028466534,
-0.014019835,
0.023677647,
-0.004075223,
0.03412249,
-0.010037988,
0.039751768,
-0.027692843,
0.00889079,
-0.019355644,
0.005799356,
-0.041219115,
-0.00831719,
0.032548428,
0.0106249275,
-0.02357093,
0.027426053,
-0.011685419,
-0.00012120204,
0.014526737,
-0.006079486,
-0.013659668,
-0.044874143,
-0.02550516,
-0.007016587,
0.010418165,
0.01165207,
0.010198062,
-0.015380466,
-0.034789465,
-0.003831777,
-0.014806867,
-0.0025578528,
0.012819278,
0.006086156,
-0.025945365,
-0.018115068,
0.031054402,
-0.015874028,
0.009464389,
-0.016460966,
0.0014223263,
-0.008950817,
-0.011725438,
-0.022637164,
0.01084503,
0.0099579515,
-0.015420484,
-0.024904883,
-0.013459575,
0.01055823,
0.0062528998,
-0.017528128,
-0.0012647532,
0.020049298,
0.014606774,
-0.021983529,
-0.006743127,
-0.013859761,
0.0044487296,
-0.009024185,
0.018661987,
-0.020702934,
0.015447164,
-0.018168425,
0.026478946,
0.023757685,
-0.008777404,
-0.026665699,
-0.00016486812,
-0.021223176,
-0.014113212,
0.007850307,
-0.016327571,
0.008090419,
-0.03719058,
-0.015393806,
0.01939566,
0.0077302516,
-0.0053324727,
0.010384816,
-0.01719464,
0.041005682,
0.014046514,
-0.012352395,
-0.017741561,
-0.013166105,
-0.015073657,
-0.015233731,
0.02026273,
0.01084503,
-0.0062095462,
0.0038417815,
-0.017421413,
-0.031214476,
-0.0023911088,
-0.01165207,
-0.021263193,
-0.01388644,
-0.007903665,
-0.006432983,
0.0038384467,
-0.009097552,
-0.01222567,
0.018501913,
0.0066664247,
0.0013773054,
-0.029587055,
-0.0049489615,
0.013766384,
-0.0098312255,
-0.017061245,
-0.010464853,
0.009384352,
0.022130262,
0.03692379,
-0.004415381,
0.019048834,
0.03246839,
-0.0338557,
0.04418049,
-0.021276534,
-0.0064830063,
0.0038451166,
0.0019092187,
0.0019459024,
0.006673095,
-0.026879132,
0.028519893,
-0.002441132,
-0.030921007,
0.018195104,
-0.00554924,
0.018835401,
-0.038711287,
0.0021443279,
-0.012925995,
-0.010318118,
0.020222712,
-0.012192321,
0.017034566,
0.009657812,
0.014033174,
0.009117561,
0.012819278,
-0.013106078,
0.0009220943,
-0.021610022,
-0.022063565,
-0.0044287206,
0.006362951,
0.014059854,
0.0009996302,
0.024891544,
0.008410567,
0.022503769,
0.023931097,
0.002342753,
-0.0027412712,
-0.003248173,
0.021596681,
0.024731468,
0.016194176,
-0.02439798,
0.012432432,
-0.0035950006,
-0.018968796,
0.03663032,
-0.00485225,
-0.011992228,
-0.007556838,
0.01583401,
0.012272358,
0.012259019,
-0.003695047,
0.028493214,
0.018742025,
-0.036523603,
0.026705718,
-0.047808837,
0.020676255,
-0.023704326,
0.0053758263,
-0.02052952,
-0.0072033405,
0.027452732,
0.027399372,
0.030120635,
-0.0019308955,
0.0063329367,
-0.012245679,
-0.006216216,
0.0007357579,
0.0026462271,
0.0046188086,
0.005802691,
-0.009237617,
-0.012619185,
-0.0029813827,
-0.03302865,
-0.0043520182,
0.0039484976,
-0.020302748,
0.025638556,
-0.010138035,
-0.014780188,
0.0077302516,
0.026265513,
0.005779347,
0.017047906,
-0.035136294,
0.034309246,
0.029026795,
-0.0117120985,
0.0041752695,
-0.018635308,
0.0144467,
-0.0058760582,
0.03134787,
0.030414104,
0.007636875,
0.0027829572,
0.018141747,
-0.0018475235,
-0.006863183,
0.023997795,
-0.009070873,
0.01303271,
-0.0027829572,
-0.004078558,
0.008350539,
-0.002584532,
0.0040452094,
0.045914628,
-0.0014398344,
-0.0072967173,
-0.008150446,
-0.00969783,
-0.022343695,
-0.015673935,
-0.02219696,
-0.008490604,
-0.0031247823,
0.0064996807,
-0.009057534,
-0.01835518,
0.011998897,
0.0058560492,
-0.014273286,
-0.008223814,
-0.041219115,
0.0073434054,
0.0020176023,
0.020449484,
0.023370838,
-0.027426053,
0.001402317,
0.006079486,
0.024944901,
0.0096644815,
-0.028706646,
0.0142999645,
-0.011738777,
0.007410103,
-0.010658276,
0.033829022,
0.013072729,
-0.015046978,
0.028386498,
0.012519139,
-0.027052546,
0.004965636,
0.012939334,
0.0073434054,
0.006272909,
0.015140355,
0.03468275,
0.017341375,
0.0048155664,
-0.0059394212,
-0.0014248274,
-0.007683563,
-0.030947685,
-0.025651896,
-0.0054025054,
-0.027612805,
0.026145458,
0.010398155,
-0.018288482,
0.022610486,
-0.0022026883,
0.013019371,
0.019382322,
-0.0015473843,
0.0098312255,
0.018768704,
-0.0007761933,
0.0015707284,
0.006856513,
-0.030867647,
-0.012372404,
0.0014823541,
-0.025318408,
0.024224568,
-0.010378147,
-0.003524968,
-0.009557766,
0.01996926,
-0.0112518845,
-0.0039284886,
-0.011885512,
-0.014500057,
-0.008310521,
-0.004888934,
-0.019022156,
0.009777868,
0.012365734,
-0.011058462,
-0.010858369,
-0.011805475,
0.000013365573,
-0.041005682,
-0.012365734,
-0.016567683,
-0.009804547,
-0.009577775,
-0.0021043092,
0.008657348,
0.010938406,
0.0056292773,
-0.011071801,
0.0061661927,
-0.008377219,
-0.028493214,
-0.0155938985,
0.02803967,
-0.008170456,
-0.013012702,
0.007990372,
0.016487647,
-0.022583807,
-0.016447628,
0.01778158,
0.023917759,
0.00084205717,
0.00832386,
0.006493011,
0.006016123,
0.009084213,
0.011665409,
0.028946757,
-0.019368982,
-0.0048422455,
-0.0030530826,
-0.019649113,
-0.032361675,
-0.010764992,
-0.013592971,
-0.008303851,
-0.02169006,
0.01053155,
-0.004075223,
-0.010017979,
0.0039851815,
-0.0041052373,
0.00032744353,
0.020196032,
0.014846886,
0.02165004,
-0.007183331,
0.024904883,
0.019328963,
-0.013306171,
0.005552575,
-0.02582531,
0.028706646,
0.0119322,
-0.033508874,
0.02441132,
-0.0074301125,
-0.035616517,
-0.04196613,
-0.008377219,
-0.006352946,
0.05389166,
0.0035783262,
-0.02165004,
-0.014913583,
-0.0054025054,
-0.0026695714,
-0.004081893,
-0.013899779,
-0.012372404,
0.0033815682,
0.02167672,
0.0065597086,
0.002831313,
0.01776824,
-0.034869503,
-0.0012289032,
-0.008130437,
-0.009591115,
0.01081835,
-0.016340911,
0.0076435446,
-0.02747941,
-0.0018158421,
0.009977961,
-0.039858483,
0.006432983,
-0.019915903,
0.030200671,
0.028253103,
0.025745273,
0.0017066248,
0.04004524,
0.024224568,
0.001333952,
0.008503944,
0.00079245085,
0.003316538,
-0.014886904,
0.00471552,
0.0026845783,
0.000012101967,
0.011051792,
-0.03529637,
0.038844682,
0.023024011,
0.0017591491,
-0.029827166,
0.010017979,
-0.034095813,
-0.028413177,
0.0028830036,
-0.004638818,
0.019222248,
-0.039858483,
-0.0067497967,
0.022757221,
-0.027879596,
-0.016821135,
-0.020769631,
0.022503769,
-0.00010233912,
0.058693886,
-0.010564899,
0.011498665,
0.013819742,
-0.032521747,
0.01303271,
-0.01722132,
0.0099913,
0.008984166,
0.030360747,
-0.0016157493,
-0.025731932,
0.021583343,
-0.003218159,
-0.024011135,
-0.02246375,
-0.004385367,
-0.0077969492,
-0.032041527,
-0.022170281,
0.0074567916,
-0.044047095,
-0.00093793496,
0.01303271,
-0.03137455,
0.030360747,
-0.021156479,
-0.0070699453,
0.011865502,
-0.017834937,
-0.007803619,
-0.022810578,
0.031454585,
0.023824383,
-0.03158798,
-0.03161466,
0.0060728164,
0.015140355,
-0.018661987,
0.03913815,
0.023010671,
-0.011852163,
-0.0028029666,
0.013139427,
-0.0058427094,
-0.030707574,
-0.029320264,
0.00651969,
-0.022090245,
0.018835401,
0.0077636004,
-0.00040414574,
-0.016474307,
0.0027662828,
-0.04025867,
-0.000089260146,
-0.012052256,
-0.009451049,
-0.0102914395,
0.009857905,
-0.005599263,
0.019115532,
-0.0013556287,
-0.010698294,
-0.009757859,
-0.0227839,
-0.013699686,
0.02663902,
-0.0038684607,
0.035990022,
0.01470015,
0.009577775,
-0.009297645,
0.0016782783,
0.026585663,
-0.009117561,
-0.025038278,
0.04273982,
-0.013126087,
-0.0058327047,
-0.0042119534,
0.01084503,
0.015967404,
0.01584735,
-0.0024427995,
-0.017541468,
-0.019609094,
0.0047822176,
0.012952673,
0.0071766614,
-0.004672167,
0.020782972,
-0.012819278,
-0.022397052,
-0.004358688,
-0.04164598,
0.017968332,
-0.03809767,
-0.022917295,
-0.010238081,
0.019609094,
0.013279492,
-0.0060094534,
-0.0065663783,
-0.0061795325,
0.018982137,
-0.025625218,
0.009270966,
0.0061495183,
-0.017354716,
-0.0031514615,
-0.00039560013,
-0.01862197,
-0.019315625,
0.0039751767,
-0.002611211,
-0.014620113,
-0.014660132,
0.0017032899,
-0.008223814,
0.009511078,
-0.016981209,
0.036817074,
-0.024798166,
0.014846886,
-0.025158335,
-0.027612805,
0.025451804,
0.0027579456,
0.040151954,
-0.012605846,
0.01055156,
-0.010871708,
0.0025211691,
-0.012805939,
-0.011311913,
0.009877915,
-0.014473379,
0.011051792,
0.028760005,
-0.008944148,
0.00029638744,
-0.004662162,
-0.007163322,
-0.005722654,
0.02610544,
0.01856861,
-0.00693655,
-0.016887832,
0.017408073,
-0.0050356686,
0.02249043,
-0.0166744,
0.0074901404,
0.010738313,
0.0005852714,
-0.017394733,
-0.004338679,
-0.02582531,
0.047915556,
0.017274678,
0.0017491445,
-0.009184259,
-0.0018708676,
-0.023170745,
-0.0120856045,
0.016207516,
0.026052082,
0.011852163,
0.02027607,
0.014606774,
0.0072900476,
-0.013793063,
0.013766384,
-0.012685883,
-0.009110892,
0.005806026,
0.01305939,
0.005589259,
-0.006026128,
-0.020903027,
-0.009531086,
0.041485906,
0.002197686,
-0.009204268,
-0.0021843463,
-0.0025195018,
0.00016038687,
-0.009511078,
0.007957024,
0.0037684143,
-0.008817422,
0.022757221,
-0.010178054,
-0.008970827,
0.013713026,
0.005442524,
-0.014313305,
0.018968796,
0.009024185,
0.006779811,
-0.0032415031,
-0.0060127885,
-0.003778419,
-0.0046054693,
-0.021303212,
0.026345551,
0.013739705,
-0.009597784,
-0.00017258004,
0.010678286,
-0.018328499,
0.0036583631,
-0.0024728135,
0.016794454,
-0.007523489,
-0.008170456,
-0.004775548,
-0.019195568,
0.002194351,
-0.0016749434,
-0.024838185,
-0.011818814,
-0.026145458,
-0.026465606,
-0.034576036,
0.01663438,
-0.019742489,
-0.010111356,
-0.017341375,
-0.0120856045,
-0.026025403,
0.0073100566,
0.010244751,
0.013899779,
-0.00915091,
0.0013097741,
-0.0054158447,
-0.024931561,
-0.0067331223,
-0.006412974,
-0.01611414,
-0.033962417,
0.010951745,
0.17330703,
-0.006576383,
-0.0008595653,
0.006766471,
-0.003313203,
-0.040418744,
0.012098944,
-0.005335808,
-0.0107516525,
0.02633221,
0.031027723,
-0.0101246955,
0.01220566,
-0.00125058,
0.010151374,
-0.0053691566,
-0.04356687,
0.0077836094,
-0.035589837,
-0.018635308,
-0.012392414,
-0.007183331,
-0.010678286,
0.011698758,
0.024197888,
0.014913583,
-0.044313885,
0.012359065,
0.028413177,
-0.0015182041,
-0.004111907,
-0.0020559535,
-0.013139427,
-0.020716274,
-0.0015557215,
-0.00046646633,
0.00046313144,
-0.02002262,
-0.0060628117,
0.025064956,
-0.007303387,
0.0383111,
-0.00028263108,
0.0052924543,
-0.021756757,
-0.0072366893,
-0.014206588,
-0.027906274,
-0.009571105,
-0.0108783785,
-0.04855585,
-0.0021960184,
-0.00044020414,
0.031748056,
0.011718768,
-0.018168425,
-0.0018291816,
0.029613733,
-0.006689769,
-0.014780188,
-0.009591115,
0.02413119,
-0.021810114,
0.019462358,
-0.003695047,
0.04644821,
-0.006856513,
-0.0024944902,
0.019342303,
-0.03390906,
-0.005409175,
-0.042633105,
-0.011425299,
-0.004255307,
-0.008243823,
-0.02191683,
0.031481266,
0.019782508,
-0.007530159,
0.022450412,
-0.002316074,
0.005529231,
-0.04916947,
0.01944902,
-0.0051990775,
-0.04407377,
0.02083633,
0.019795846,
-0.0032231614,
-0.02803967,
0.00777027,
-0.0043720277,
-0.007696903,
0.010244751,
0.007576847,
0.012972683,
-0.0000052628575,
-0.0030580848,
0.008583981,
-0.039244868,
-0.032975294,
0.09492402,
-0.0110451225,
-0.02219696,
-0.028493214,
0.017301356,
-0.012619185,
0.011171848,
0.0017124608,
0.0073967637,
-0.013072729,
-0.0051657287,
-0.00944438,
-0.002384439,
0.025225032,
0.008784073,
0.02694583,
-0.024864864,
0.014940262,
-0.00092793035,
0.004635483,
-0.011685419,
0.0114186285,
0.0075968564,
-0.011665409,
0.0052591055,
0.0038484514,
-0.011038452,
0.0010604918,
-0.042259596,
0.002986385,
0.01642095,
0.013239473,
-0.010738313,
-0.005329138,
0.003153129,
0.013532942,
0.0030797615,
-0.0088707805,
0.0030230687,
-0.016514326,
0.019315625,
0.0044520646,
0.008197134,
-0.008510614,
-0.033962417,
0.036576964,
-0.0004898105,
-0.03196149,
-0.0066764294,
-0.045701195,
-0.008110428,
-0.01305939,
0.010951745,
0.002206023,
-0.026465606,
-0.025785292,
-0.015740633,
0.0034099147,
0.023784364,
-0.023437535,
0.023264121,
0.022703862,
-0.007663554,
0.00019123452,
0.0055925935,
-0.16722421,
0.007850307,
0.013519603,
-0.04879596,
0.050423384,
-0.010658276,
0.030467462,
-0.0025178343,
-0.0017224655,
0.011325252,
0.018702006,
0.0012739241,
-0.012885976,
-0.038924716,
-0.00222103,
-0.010078007,
-0.021249855,
0.024291266,
0.031027723,
-0.00638963,
0.014793527,
-0.022810578,
0.016274214,
-0.0061495183,
0.00117888,
0.01555388,
0.01831516,
-0.01747477,
0.0024194554,
0.012659204,
-0.025185013,
-0.022610486,
0.025892008,
-0.012405753,
0.015900707,
-0.006776476,
0.0013222799,
0.019942582,
0.0047388645,
-0.012879306,
0.020702934,
0.015607238,
0.026585663,
0.00008863486,
-0.012472451,
0.03668368,
0.032548428,
0.007256699,
0.029533695,
-0.009057534,
0.0048455806,
0.011011774,
0.027239298,
0.01249246,
0.034869503,
0.019355644,
-0.0035783262,
0.03140123,
-0.013846422,
-0.029827166,
-0.013639659,
-0.017648185,
0.03476279,
-0.01695453,
0.023557592,
-0.0026578992,
-0.006883192,
0.0026195482,
-0.017648185,
0.009477729,
-0.0072500287,
-0.004422051,
-0.010518211,
-0.010057998,
0.019662451,
-0.00277462,
-0.022383714,
0.0070966245,
-0.010778332,
-0.01690117,
0.005005655,
0.020689595,
-0.002622883,
-0.008810753,
0.012078935,
0.010318118,
0.021996867,
0.01137194,
-0.0077369213,
-0.021129798,
0.007823628,
-0.014540076,
0.030921007,
-0.0011196859,
0.01193887,
0.02719928,
-0.017794918,
-0.004598799,
-0.015287089,
-0.0069498895,
0.0097045,
-0.004805562,
-0.019222248,
0.028519893,
0.030894328,
-0.008717376,
0.0046488224,
0.009651142,
0.059867762,
-0.027506089,
0.017181301,
0.014139891,
0.010091347,
0.03158798,
-0.002467811,
0.031187797,
-0.0070966245,
-0.00037955103,
0.010371476,
-0.0027079224,
0.078222945,
0.011838824,
-0.011458647,
0.03609674,
0.011512006,
-0.01690117,
-0.11728106,
0.0010338128,
-0.021543324,
0.0030163988,
-0.00090458617,
0.013913119,
0.0012005568,
0.019102192,
-0.010871708,
0.0075835166,
-0.017594825,
-0.05327804,
-0.007376754,
-0.010304779,
-0.0047021806,
-0.00014058602,
0.0049256175,
-0.010104686,
-0.024197888,
0.027426053,
-0.0039518327,
0.0056526214,
-0.012239009,
0.00037642458,
-0.018955458,
-0.017341375,
-0.027292658,
-0.0002876334,
-0.00069865736,
0.0033899054,
-0.00270959,
-0.010971755,
0.013359529,
-0.007383424,
-0.014913583,
-0.0063929646,
-0.009050864,
-0.016274214,
0.032014847,
-0.017047906,
0.011978889,
0.015020299,
0.021463286,
-0.0017016225,
0.014913583,
-0.011592043,
-0.02607876,
0.027879596,
0.02665236,
-0.015287089,
-0.0030530826,
-0.02362429,
-0.03110776,
-0.016727757,
0.017754901,
-0.0288934,
0.003024736,
0.04444728,
-0.004278651,
-0.006723118,
-0.013286161,
0.0022193627,
-0.0033565566,
0.025985384,
-0.0028713315,
-0.02466477,
-0.016154159,
-0.044527315,
0.03887136,
-0.0449275,
-0.0035583167,
0.0101246955,
-0.01167875,
-0.029373622,
-0.021890152,
0.010758323,
-0.039911844,
-0.028012991,
0.008190465,
-0.022437071,
-0.0030947686,
-0.013066059,
0.042019486,
-0.008904129,
0.020209372,
0.034736108,
0.005472538,
-0.012445772,
-0.009050864,
-0.013713026,
0.006136179,
0.010965085,
0.0010946743,
-0.009691161,
-0.01668774,
0.011078471,
-0.010138035,
-0.003965172,
0.028119707,
0.021556664,
-0.03772416,
-0.033935737,
-0.04826238,
0.033989094,
0.011832153,
-0.023450876,
0.0025995388,
-0.018488575,
-0.004278651,
-0.010057998,
0.023517573,
0.020462822,
-0.02195685,
0.008090419,
0.011345262,
-0.015287089,
-0.0142599465,
-0.024824847,
0.04660828,
0.012579167,
0.035696555,
0.018822063,
-0.016300892,
0.013439566,
0.004395372,
0.051437188,
0.023704326,
-0.019955922,
-0.009471059,
0.023797702,
-0.0021093115,
-0.0072900476,
0.010438174,
-0.039991878,
-0.0097912075,
-0.006439653,
-0.009797877,
-0.025491823,
-0.021770095,
0.02303735,
0.03414917,
0.058373738,
-0.0028696642,
-0.0140064955,
-0.010411495,
0.0035349727,
0.010071337,
-0.0011096813,
-0.04996984,
0.011905521,
-0.0003239002,
-0.0005969435,
0.021610022,
0.0112118665,
-0.019355644,
-0.020035958,
-0.018235123,
-0.0021409928,
0.0034916191,
-0.007823628,
-0.004265311,
-0.008630669,
0.023264121,
-0.0005052343,
0.014860225,
-0.023797702,
0.00055984297,
-0.009877915,
-0.019595753,
0.0047388645,
-0.0062262206,
-0.047275256,
-0.035696555,
0.03028071,
0.014126551,
0.019835865,
0.009190929,
0.0073233964,
-0.010718304,
0.007930344,
0.0070699453,
0.015580559,
-0.0036550283,
0.009944612,
-0.02111646,
0.006292918,
0.020903027,
-0.0166744,
-0.0041252463,
0.0135062635,
-0.011718768,
0.011265224,
-0.028146386,
0.023731004,
-0.0074034333,
0.016541004,
0.005826035,
0.0073100566,
0.0083372,
-0.00889079,
-0.0032398358,
0.026785756,
-0.009397691,
-0.007376754,
-0.02830646,
-0.027119244,
0.0022276998,
0.01690117,
-0.026478946,
-0.03777752,
0.013546282,
-0.0072633685,
0.013966477,
0.017661523,
-0.0039618374,
0.0025111646,
-0.0028513223,
-0.0009521082,
-0.015500521,
-0.007830298,
0.011552024,
0.023757685,
0.027079225,
0.020196032,
-0.0006961562,
0.023437535,
0.007196671,
0.005515891,
0.0040118606,
-0.046661638,
0.0227839,
0.0022293671,
-0.0065663783,
0.008290512,
-0.03518965,
0.0072500287,
-0.0074634613,
-0.014246607,
0.022370374,
0.011471987,
-0.0063929646,
0.07288714,
0.0011213534,
0.014580095,
0.008497274,
-0.02553184,
0.018835401,
0.013232803,
0.000114219634,
0.0035016239,
-0.027532768,
0.027959634,
-0.015633916,
0.032441713,
-0.015220392,
-0.029186869,
0.02277056,
0.006506351,
0.017528128,
-0.008730715,
-0.005912742,
0.0018892095,
0.0014039844,
0.02607876,
0.025705254,
-0.0042086183,
-0.0037083863,
0.04468739,
-0.0031681359,
0.02331748,
-0.034576036,
0.003908479,
-0.012178982,
-0.020436144,
-0.013086068,
-0.0028413176,
-0.028466534,
-0.0068365037,
0.0149269225,
0.0049489615,
-0.006876522,
-0.007303387,
0.003721726,
-0.016194176,
-0.017234659,
-0.00638963,
-0.0036316842,
-0.0035049587,
-0.01776824,
-0.007843638
] |
PD-L1 is an immunoinhibitory molecule that suppresses the activation of T cells, leading to the progression of tumors. Overexpression of PD-L1 in cancers such as gastric cancer, hepatocellular carcinoma, renal cell carcinoma, esophageal cancer, pancreatic cancer, ovarian cancer, and bladder cancer is associated with poor clinical outcomes. In contrast, PD-L1 expression correlates with better clinical outcomes in breast cancer and merkel cell carcinoma. The prognostic value of PD-L1 expression in lung cancer, colorectal cancer, and melanoma is controversial. Blocking antibodies that target PD-1 and PD-L1 have achieved remarkable | [
-0.014618842,
0.008827834,
0.016038656,
-0.024360353,
-0.011036437,
0.0019489598,
-0.036652274,
0.014592549,
-0.02563556,
-0.010484286,
0.014829185,
0.008150793,
0.011082449,
0.020061469,
-0.028133383,
0.017353302,
0.03786175,
-0.031235943,
-0.003960365,
0.004213434,
-0.031630334,
-0.020232372,
-0.018891435,
-0.018444456,
-0.01724813,
0.022625023,
0.02518858,
-0.0535586,
-0.001409134,
-0.0057877204,
0.0034115012,
0.0070662117,
-0.011522855,
0.023387518,
0.012521984,
-0.010556592,
0.003835474,
-0.0052552894,
0.019036045,
0.0012464469,
0.022927392,
0.008209952,
0.0051534045,
-0.0013401152,
-0.020061469,
-0.00072839495,
0.009511449,
-0.017905451,
-0.020140346,
0.009432571,
0.006119668,
0.0005028513,
-0.0046899924,
-0.02230951,
-0.0072699813,
-0.020823961,
0.00949173,
0.026135122,
-0.0044402103,
-0.017090373,
-0.010188491,
-0.018720532,
-0.033365667,
0.011332232,
0.014408498,
0.01898346,
-0.008019328,
0.034838066,
0.013777469,
-0.0000386947,
0.03762511,
0.03778287,
-0.030604914,
-0.0046406933,
0.01831299,
-0.039097514,
-0.031078184,
0.0034706602,
-0.005656256,
0.014434791,
0.016538221,
-0.038939755,
0.0007772833,
0.0069807596,
0.021783652,
0.022533,
-0.01857592,
0.006336584,
-0.00037816557,
-0.023348078,
0.021691626,
0.019417292,
-0.0029941017,
0.01373803,
-0.0069150277,
0.013803762,
0.0030335411,
0.02839631,
-0.0008356206,
-0.03851907,
0.0042923125,
-0.005547798,
-0.024991384,
-0.005781147,
-0.028264847,
0.0030154646,
0.0037303024,
0.00066718186,
0.010227931,
0.0050942455,
-0.035521682,
0.042147487,
-0.008808115,
-0.03678374,
0.034364793,
-0.01592034,
0.0032734636,
0.007197676,
-0.0051862705,
-0.015355042,
0.022848513,
-0.005426193,
0.030631205,
-0.025162287,
0.010668336,
-0.0025668424,
0.010760361,
-0.0106223235,
-0.015946632,
0.020258665,
0.01820782,
0.035916075,
0.0027952618,
0.010326529,
0.00039952854,
-0.011752917,
-0.02245412,
-0.016393611,
-0.012502264,
-0.020403275,
-0.00057022687,
0.021139476,
0.0061985464,
-0.00832827,
0.006221553,
0.01333049,
0.020837108,
0.00078755396,
0.0014904777,
0.002359786,
-0.021717919,
-0.019298974,
-0.01724813,
-0.004703139,
-0.0056266766,
-0.0042200075,
0.016117536,
0.036126416,
-0.0033605588,
-0.01853648,
-0.0025191866,
-0.013856348,
0.005505072,
0.02408428,
0.012922951,
0.026345467,
0.021218354,
0.0310256,
-0.026687274,
0.0024830338,
0.0045289486,
0.055793494,
-0.028606653,
0.02415001,
-0.019272681,
0.0059717703,
-0.008032475,
0.003388495,
-0.0034772335,
-0.004476363,
-0.0064253225,
0.028816996,
0.0034279344,
-0.010024161,
-0.0127389,
-0.000815901,
0.017497912,
-0.024491819,
-0.014816038,
-0.031078184,
0.0033917816,
0.021441843,
0.01198298,
-0.033365667,
-0.6230361,
-0.029185098,
0.016117536,
0.00062075845,
0.009077617,
0.03186697,
0.016117536,
-0.009583755,
-0.028185967,
0.010523725,
-0.00049422396,
-0.002047558,
-0.009425998,
-0.00736858,
-0.00734886,
-0.041490164,
-0.009886123,
-0.004482936,
-0.0019226669,
0.009136776,
-0.0064746216,
0.0013368287,
0.01547336,
0.0061985464,
-0.015144699,
0.004831317,
0.03202473,
-0.00984011,
-0.00072675163,
0.036179002,
-0.016209561,
0.01857592,
-0.0024041552,
-0.020455861,
0.04446126,
0.003809181,
-0.013646005,
-0.007223969,
0.01275862,
0.055320222,
0.0024337347,
0.01179893,
0.012239336,
-0.007585496,
-0.02263817,
0.008499173,
0.011286219,
0.0072371154,
0.0015512799,
-0.013153014,
-0.0005739243,
0.026227148,
-0.036810033,
0.0005164086,
0.01296239,
0.011792357,
0.031525165,
-0.026766153,
0.0139483735,
-0.0139483735,
0.015775729,
0.0042002876,
-0.0030335411,
-0.009958428,
0.00077974825,
0.015788876,
0.021060597,
0.0022168185,
-0.003114063,
0.007901011,
0.000792073,
0.037125546,
0.011700332,
-0.0020459148,
0.04306774,
0.04845778,
-0.010688056,
-0.0013113574,
-0.002806765,
0.006675105,
0.016906323,
0.0015364902,
-0.038545363,
0.017852865,
0.0066619585,
-0.008137646,
-0.02404484,
0.027318303,
0.007697241,
0.0133830765,
0.034312207,
-0.015815167,
-0.009616621,
-0.030736377,
-0.019285828,
0.011338805,
-0.020035176,
0.009833537,
0.0015594965,
-0.024255183,
-0.037125546,
-0.014158716,
0.008453161,
-0.0074145924,
0.037125546,
0.009057897,
-0.031104477,
0.014526816,
0.02921139,
-0.040201813,
-0.004305459,
-0.0018766543,
-0.01816838,
-0.0026407912,
0.02921139,
-0.016025512,
0.015328749,
0.020153493,
0.000040158266,
-0.016525075,
0.0002736103,
-0.005899465,
0.009925562,
-0.002806765,
0.013277905,
0.00598163,
0.0054327664,
-0.0077761193,
0.019338414,
-0.007993036,
-0.011286219,
-0.01857592,
0.02116577,
-0.010398834,
0.014973795,
0.012324788,
0.01953561,
0.007053065,
0.0074145924,
-0.009294533,
-0.025017675,
-0.023085149,
0.023150882,
0.003324406,
-0.013777469,
-0.016038656,
-0.015525946,
0.00832827,
0.0075066173,
0.0153156025,
0.0046472666,
-0.028527776,
0.007072785,
0.023177175,
0.016564514,
-0.0020672777,
0.012232763,
0.0058600255,
-0.0044007706,
-0.008137646,
-0.015933486,
-0.0069741867,
-0.004897049,
-0.023072002,
-0.012890085,
-0.0061459607,
0.027607525,
0.02839631,
-0.016301585,
-0.048484072,
-0.007309421,
-0.0009637984,
-0.0011149824,
0.0049036224,
0.012784913,
-0.012449679,
-0.01279806,
-0.016538221,
0.017011493,
0.008873847,
0.010582885,
-0.02729201,
0.0023959388,
0.010510579,
0.02153387,
0.011976407,
0.026200855,
0.01592034,
0.010872106,
0.03504841,
-0.011568868,
0.03570573,
-0.013895787,
0.012055285,
-0.010957558,
-0.009195935,
-0.00079248386,
0.0134290885,
0.004341612,
0.024649575,
-0.0043284656,
-0.004154275,
0.01676171,
-0.0051698377,
0.0050942455,
-0.011785784,
0.00639903,
-0.023177175,
-0.0029973884,
0.020390129,
0.01728757,
0.0064023165,
-0.013231892,
-0.0030943435,
-0.0030351845,
0.01373803,
-0.0066520986,
-0.012456252,
-0.009912416,
-0.0053637475,
-0.00869637,
0.018299844,
0.006431896,
-0.027923038,
-0.0116608925,
-0.0097743785,
0.0313937,
0.018996606,
-0.009478583,
-0.013205599,
-0.02415001,
0.011345378,
0.0068492955,
0.006349731,
-0.008085061,
0.015092113,
0.022874806,
-0.0032718203,
0.046959084,
-0.0031419992,
-0.008637211,
0.0084926,
-0.01392208,
0.01835243,
-0.011838369,
-0.014842331,
0.022362094,
-0.006044076,
-0.025464654,
0.035311338,
-0.002941516,
0.02422889,
-0.013646005,
-0.0034673735,
-0.011838369,
-0.015565385,
0.02104745,
0.009800672,
0.06152534,
0.012653449,
0.01204214,
-0.030499741,
0.021744212,
0.004045817,
0.0023203467,
-0.0011536002,
0.017300716,
-0.015631117,
0.005209277,
0.008065341,
-0.025872195,
-0.0069413204,
0.03557427,
-0.046696156,
-0.004620974,
0.01592034,
-0.0011930395,
0.02810709,
0.019640781,
0.019298974,
-0.013790616,
-0.019601343,
0.031051893,
0.027239425,
-0.009163069,
-0.029500611,
-0.035442803,
0.0026868037,
-0.018444456,
-0.015210431,
0.017353302,
0.0065370672,
-0.0041674217,
0.019049192,
-0.0012875295,
-0.014802892,
0.0085714795,
0.02008776,
0.00716481,
0.0072436887,
0.0033753486,
-0.0067309774,
-0.004551955,
-0.011121889,
0.023795057,
0.019298974,
0.00022903564,
-0.01102329,
-0.004693279,
-0.0044204905,
-0.016091242,
-0.020771375,
0.00031099547,
-0.01824726,
0.010911546,
0.006993906,
0.025727583,
0.011095596,
0.011397963,
0.018273553,
-0.028264847,
-0.02304571,
0.007868145,
-0.0017287569,
0.015604825,
0.017471619,
-0.00086273515,
0.015999218,
-0.0101753445,
0.011562294,
-0.02278278,
-0.02702908,
0.018523334,
-0.020850254,
-0.025990512,
-0.0032833235,
-0.01081952,
-0.005067953,
0.016998347,
0.021139476,
0.00484775,
-0.032629464,
-0.0005866599,
-0.0022381814,
-0.005337455,
-0.007901011,
0.036836326,
0.013107001,
0.009452291,
-0.008683224,
0.028317433,
0.026529517,
0.025661852,
-0.024623282,
-0.012252483,
0.02810709,
0.009925562,
0.009780952,
-0.014421645,
-0.024294622,
0.03231395,
0.003232381,
0.014316473,
0.010668336,
0.008301977,
0.020889694,
0.008262537,
-0.0016424834,
0.006211693,
0.0019243102,
-0.007079358,
0.03021052,
0.009669207,
-0.024531258,
0.011621453,
-0.021547016,
-0.0070596384,
-0.023584714,
0.0007366115,
0.00967578,
0.008236245,
-0.0065436405,
0.007993036,
-0.0046406933,
0.006783563,
-0.028527776,
-0.008012756,
-0.0015036241,
-0.013724884,
-0.0030631206,
-0.005058093,
-0.022204338,
-0.014631988,
-0.016722271,
0.022243777,
-0.021178916,
-0.01761623,
0.003733589,
0.0063267243,
0.00736858,
0.009452291,
-0.00465384,
0.007828705,
0.04893105,
0.01716925,
-0.005636536,
-0.012732327,
-0.047511235,
0.00021116469,
-0.010273943,
-0.0028840003,
-0.019193802,
-0.033628594,
-0.0113782445,
-0.007979889,
-0.014474231,
-0.00212315,
0.002639148,
-0.0039143525,
0.013935227,
0.014829185,
0.016735418,
-0.002090284,
-0.0069676135,
-0.018326137,
-0.017221836,
-0.024176303,
-0.010589458,
-0.0040523903,
-0.034022987,
0.012410239,
0.0075723496,
0.005008794,
-0.00031079006,
0.0097743785,
-0.013527687,
0.002931656,
0.003700723,
0.009031604,
0.030368278,
-0.0062544188,
0.0048444634,
0.006159107,
-0.012587717,
-0.027265716,
0.0011059443,
0.03076267,
-0.0021839524,
0.0012842428,
-0.017721402,
-0.012259056,
-0.018339284,
-0.018786263,
-0.0131464405,
-0.012896658,
0.023795057,
0.01565741,
0.0043711914,
-0.021717919,
0.0059651975,
-0.0076315086,
0.0015767511,
-0.008538613,
-0.032734636,
-0.021744212,
0.020008883,
0.015065821,
-0.019417292,
0.030552328,
-0.029290268,
-0.023518981,
0.018115794,
0.015039528,
0.0018289984,
-0.0017205403,
0.024754748,
-0.020363836,
0.005445913,
-0.00004909374,
-0.030973013,
-0.01196326,
-0.0040030912,
0.043330666,
0.029737247,
0.026371758,
-0.00853204,
0.011726624,
0.027370889,
0.009143349,
0.0017435467,
-0.007046492,
0.022151751,
-0.0014945859,
0.011463696,
0.0048444634,
-0.016262146,
0.04830002,
-0.0122261895,
0.013100428,
-0.0017041073,
-0.010550018,
-0.0063267243,
-0.00097530155,
-0.020192932,
-0.053348254,
0.024938798,
-0.011568868,
0.0071779564,
-0.022835366,
-0.019022899,
0.008387429,
0.014014105,
-0.0046998523,
-0.0070399186,
0.007901011,
-0.022151751,
0.020455861,
0.003750022,
0.002052488,
-0.0041509885,
-0.017563645,
0.005774574,
-0.010530299,
0.020929134,
0.0037664552,
0.026319174,
0.00427588,
-0.035469096,
-0.009156495,
-0.016262146,
-0.023834497,
-0.007467178,
-0.028264847,
-0.035679437,
-0.011299365,
-0.008702943,
-0.015552239,
-0.042568173,
0.01684059,
0.012883511,
-0.01728757,
0.013843202,
0.0068098563,
-0.03147258,
0.035547975,
0.009143349,
0.00794045,
-0.020561032,
0.025438363,
0.020666204,
-0.0012423386,
-0.018444456,
-0.013435662,
0.0045059426,
-0.003506813,
0.014342766,
0.0197591,
0.010904972,
-0.006168967,
-0.020258665,
0.0131464405,
0.005452486,
-0.02282222,
0.022178045,
0.009458864,
-0.011075876,
-0.027186839,
-0.027528645,
-0.01220647,
-0.012699462,
0.0021083604,
0.0037697416,
-0.011562294,
-0.007697241,
-0.00541962,
-0.004683419,
-0.008821261,
0.0048576095,
-0.0045716744,
-0.03972854,
-0.01853648,
-0.036100123,
0.013402795,
0.0013951659,
-0.010766935,
0.019141218,
0.0039899447,
0.0030894135,
0.012298495,
-0.0016235854,
0.023334932,
0.007315994,
-0.015263017,
0.040306985,
-0.0023564994,
-0.0018092789,
-0.0046144007,
-0.021034304,
0.009866403,
-0.021034304,
-0.004722859,
-0.026582101,
-0.030341985,
-0.0021510862,
0.016853737,
0.009412851,
-0.01831299,
0.008387429,
-0.029605784,
-0.01469772,
-0.01983798,
-0.025320044,
0.018786263,
-0.02666098,
-0.022099165,
-0.012364227,
0.01336993,
0.033365667,
0.034259625,
-0.010306809,
0.009853257,
0.036205295,
-0.021586455,
0.00755263,
-0.0000845275,
0.012811206,
-0.0043448983,
0.008334843,
-0.012995256,
-0.019391,
0.011108742,
-0.016682833,
-0.015092113,
-0.046406936,
-0.012896658,
-0.007710387,
0.019601343,
-0.0057877204,
0.018365577,
0.012686315,
0.020390129,
0.0016202987,
-0.017839719,
0.0251097,
-0.015815167,
-0.0039998046,
0.02300627,
-0.01528931,
-0.013567126,
-0.012364227,
0.0075723496,
0.0077498266,
-0.006717831,
-0.028632946,
-0.041516457,
0.017379593,
-0.012101298,
0.003894633,
-0.020534739,
0.0054984987,
-0.018457603,
0.027949331,
0.00734886,
0.01979854,
0.0037072962,
0.004959495,
-0.0011379888,
0.013724884,
-0.027923038,
-0.023847643,
-0.00832827,
-0.02186253,
-0.010392261,
-0.00869637,
-0.01432962,
0.015131553,
0.017760841,
-0.014645134,
-0.026766153,
0.008282257,
-0.03633676,
-0.0037434488,
0.0033687754,
0.010076746,
0.013619713,
0.027686404,
-0.028527776,
0.0002974382,
0.0028478475,
0.025977366,
-0.004315319,
-0.044408675,
-0.005445913,
-0.02496509,
0.027265716,
0.023150882,
-0.032445416,
-0.025083408,
0.03670486,
0.0019160936,
-0.019259535,
0.033812646,
-0.041753095,
0.018483896,
-0.025977366,
0.009524596,
-0.006684965,
0.0031124197,
0.005097532,
-0.0022020286,
-0.0069478936,
0.0254778,
0.01710352,
0.012357654,
0.016170122,
0.003884773,
-0.0023630727,
-0.014198155,
0.008893567,
-0.02422889,
0.015670557,
-0.008775249,
-0.0070925043,
0.017879158,
-0.0037303024,
0.025674997,
-0.010609177,
0.014763452,
-0.027554939,
-0.018010624,
-0.009097337,
0.0024008686,
0.016222708,
0.004413917,
-0.028001918,
-0.0062839985,
-0.00051394367,
-0.01990371,
0.0029776688,
-0.0075394833,
-0.007947023,
-0.031525165,
0.026240295,
0.0021691627,
-0.012600863,
-0.010753788,
-0.008860701,
-0.019916857,
-0.03223507,
-0.0051534045,
0.008538613,
-0.030236812,
-0.0037237292,
-0.0006766308,
0.0040425304,
0.011273072,
-0.003199515,
-0.0026966636,
-0.01990371,
-0.00012191269,
0.1957242,
-0.016012365,
-0.010563165,
0.0035889782,
0.0096560605,
0.023795057,
0.010280516,
-0.008255964,
0.008446588,
-0.0022151752,
0.014553109,
-0.016301585,
-0.018996606,
0.007131944,
0.020731937,
-0.0023614294,
-0.040938016,
-0.019916857,
-0.008157366,
-0.006070369,
-0.020035176,
-0.00677699,
0.020666204,
0.020298103,
0.020810815,
-0.014382206,
0.0047557247,
0.0151972845,
0.024649575,
0.018220967,
-0.015052674,
0.026108831,
-0.0044270637,
-0.0048839026,
0.008926433,
0.000619526,
-0.030552328,
-0.02278278,
-0.0017435467,
-0.0013327204,
-0.010865533,
-0.0095377425,
-0.023400664,
-0.01351454,
0.008453161,
0.0022989837,
0.009347119,
-0.006034216,
0.017760841,
-0.013415942,
-0.035153583,
0.026950203,
0.032576878,
0.019285828,
-0.013816909,
0.015604825,
0.02378191,
0.011102169,
-0.013685444,
0.014000959,
-0.0028905736,
-0.009301106,
-0.009912416,
0.0201272,
-0.008374282,
0.025122847,
-0.028185967,
0.02163904,
-0.005150118,
-0.015815167,
0.008486027,
-0.007795839,
-0.016590808,
-0.021560162,
-0.005892892,
-0.016551368,
0.030368278,
0.016577661,
-0.0022053153,
0.040859137,
0.003334266,
0.009853257,
-0.009610048,
-0.0049332017,
-0.01724813,
-0.029316561,
0.007112224,
0.004752438,
-0.015013235,
-0.0026555809,
-0.012837498,
-0.017419033,
-0.01547336,
0.0130741345,
0.025688143,
-0.010122759,
0.005455773,
0.0052815825,
-0.014132423,
-0.04325179,
-0.015486507,
0.07667004,
0.021954555,
0.026200855,
-0.0035166729,
-0.0038124677,
-0.011010144,
-0.008624065,
0.0007497579,
-0.0036810033,
0.0047853044,
-0.027213132,
0.013935227,
-0.015092113,
-0.01957505,
0.020232372,
0.02541207,
-0.008341417,
0.02016664,
-0.004949635,
0.0043021725,
-0.0053144484,
0.010149051,
0.02282222,
-0.010129333,
0.022940539,
-0.013527687,
0.00792073,
0.00987955,
-0.0229011,
0.00011924232,
-0.012567997,
-0.0096955,
0.022664463,
0.010162198,
-0.007526337,
0.009176215,
-0.0047655846,
-0.021665333,
0.009189362,
-0.017340155,
-0.0036678568,
0.00016463862,
0.011319085,
0.027923038,
0.0062314128,
0.01257457,
-0.011358525,
-0.02574073,
-0.014566256,
-0.0069413204,
-0.027791575,
-0.029553197,
-0.0058205863,
0.025438363,
0.0006712901,
-0.018970313,
-0.0016046873,
-0.0030023183,
0.022467267,
-0.020245519,
0.009583755,
0.024859918,
-0.031919558,
-0.00057022687,
-0.0087358095,
-0.1632262,
0.011956687,
0.022125458,
-0.02578017,
0.010221357,
0.015210431,
-0.016511928,
-0.015236724,
0.0011577083,
0.020074613,
0.027607525,
-0.010241077,
-0.02145499,
-0.0011059443,
-0.0031107764,
0.016827444,
-0.0016630247,
0.042200074,
0.024689015,
0.01816838,
0.016722271,
-0.0066718184,
0.008426868,
-0.021297233,
-0.02426833,
0.009991295,
0.010352822,
-0.011253353,
-0.027265716,
-0.0026161417,
0.000038463608,
0.010878679,
0.013245039,
0.007795839,
0.014934356,
-0.0000133005005,
-0.0011724981,
-0.032419123,
-0.0038058944,
0.03239283,
0.037362184,
0.03959708,
0.030052762,
-0.010688056,
-0.009978148,
0.031735506,
0.01935156,
-0.019640781,
0.036810033,
0.014710867,
0.040201813,
-0.020994864,
0.01063547,
-0.0024386647,
0.0043383255,
0.019811686,
0.04306774,
0.005426193,
-0.011739771,
0.004394198,
-0.0016942475,
-0.016301585,
0.012936098,
0.010970704,
0.015157846,
-0.024833625,
-0.000115544884,
0.0321299,
-0.0169852,
0.000910391,
-0.031104477,
-0.02241468,
0.04133241,
-0.017918598,
0.0063004317,
0.010168771,
0.015775729,
0.015604825,
-0.012567997,
0.009662634,
-0.00024177125,
-0.02684503,
-0.009748085,
-0.014908063,
-0.011069302,
0.008867274,
0.009379985,
0.039097514,
-0.001511019,
-0.022427827,
0.033076443,
-0.0063332976,
-0.009997868,
-0.009156495,
-0.009472011,
0.02655581,
-0.011279645,
0.0042035743,
-0.022993123,
0.007986463,
0.01473716,
-0.013816909,
-0.017971184,
-0.010129333,
0.029132511,
0.0051961304,
-0.020639911,
0.0028987902,
0.037441064,
-0.003421361,
-0.024163157,
0.0117792105,
0.0069084545,
0.014000959,
-0.012377374,
0.017274423,
-0.0005307875,
0.014842331,
-0.020547885,
-0.035653144,
0.06783563,
-0.013856348,
0.017445326,
0.0075460565,
0.011167901,
-0.026227148,
-0.13693333,
-0.036547106,
0.03922898,
-0.005636536,
-0.024951944,
0.017300716,
-0.0010393905,
0.021205207,
-0.021573309,
0.03943932,
0.009715219,
0.014198155,
-0.0028889303,
-0.016314732,
0.01196326,
-0.0022759775,
0.023282345,
-0.004476363,
-0.01592034,
0.026095685,
-0.00386834,
0.0021839524,
0.012903231,
-0.018510187,
-0.002391009,
-0.009386558,
-0.029710954,
0.023177175,
0.010668336,
0.014421645,
-0.009294533,
0.010017588,
0.016380465,
-0.001201256,
-0.00890014,
-0.01410613,
-0.010359395,
-0.0050548064,
0.031735506,
-0.0002674479,
-0.007841852,
0.01953561,
-0.0023088437,
0.00067046843,
-0.014631988,
-0.025806462,
-0.022217484,
0.0052454295,
0.0458022,
-0.006921601,
-0.027581232,
-0.045223754,
-0.028080797,
0.009905843,
0.0151972845,
-0.009603474,
0.009833537,
0.025320044,
-0.00601121,
-0.0072962744,
-0.0034246477,
-0.0130741345,
-0.018260406,
0.005219137,
0.0063825967,
0.0130741345,
0.010766935,
-0.04007035,
0.025674997,
-0.01473716,
-0.023689885,
-0.020837108,
-0.022874806,
-0.008564906,
0.0045223753,
-0.00030093023,
0.008367709,
-0.014960649,
0.0066619585,
-0.023479542,
-0.029684663,
-0.016051803,
0.017497912,
-0.037809163,
0.051902145,
-0.0109772775,
0.00716481,
-0.018497042,
0.01820782,
-0.00658308,
-0.013646005,
0.048063386,
0.0039307857,
-0.02433406,
-0.008676651,
0.020968571,
-0.008650358,
-0.0153156025,
0.018418163,
0.019338414,
-0.019653928,
-0.007927303,
-0.057002965,
0.001667133,
-0.016853737,
0.015907193,
0.0028560641,
-0.012567997,
0.0050778124,
-0.015210431,
0.030315692,
-0.0025619126,
-0.014395352,
0.018851995,
-0.005791007,
0.0013968092,
-0.01216703,
-0.003076267,
0.028580362,
0.003243884,
-0.010918119,
0.026043098,
-0.00016607651,
0.0009013528,
-0.0057351347,
-0.026713567,
-0.01684059,
-0.009005312,
-0.01953561,
0.022164898,
-0.014855477,
-0.01179893,
0.016196415,
-0.02104745,
-0.029895006,
0.00023827923,
-0.024715308,
-0.018234113,
0.022086019,
0.027265716,
0.005814013,
0.020837108,
0.0030614773,
-0.04269964,
0.02496509,
0.010707775,
-0.007230542,
-0.009583755,
-0.02784416,
0.013060988,
0.014079837,
-0.008025901,
0.03252429,
0.0089724455,
0.00026785873,
-0.0138300555,
0.0096560605,
-0.0020064753,
0.006901881,
-0.014829185,
-0.03239283,
-0.0035692586,
0.023768764,
0.017681962,
-0.0072371154,
0.012160458,
0.02112633,
-0.018825702,
-0.040491037,
-0.013258185,
-0.00755263,
0.021021158,
-0.017958038,
-0.0068230024,
-0.013488248,
-0.00658308,
0.034548845,
-0.013593419,
-0.025162287,
-0.0044040573,
-0.007611789,
0.012600863,
0.00792073,
0.01081952,
-0.024623282,
0.014592549,
0.028238554,
0.007381726,
-0.024820479,
0.009741512,
0.0100636,
0.010517152,
-0.0044895094,
0.012916378,
0.0059553375,
0.021244647,
0.016866883,
0.003917639,
0.010964131,
0.0048674694,
-0.0075920695,
0.03157775,
0.013021549,
0.0009391488,
0.0024600276,
0.013606566,
-0.018733677,
0.01255485,
-0.040096644,
-0.028317433,
-0.0016202987,
-0.010425127,
0.018234113,
-0.002558626,
-0.0051796976,
-0.001239052,
-0.030657498,
0.0025832755,
0.017129812,
0.0060966616,
-0.014894917,
0.043199204,
-0.004223294,
0.0014888344,
-0.0066455253,
-0.00047286102,
-0.0045716744,
-0.009182788,
0.02386079,
-0.031998437,
0.036836326,
-0.009951855,
0.0013959876,
-0.021073744,
-0.029500611,
-0.015591678,
-0.0008758816,
-0.0030746236,
0.00987955,
0.0025734156,
-0.0067704166,
0.07214767,
0.005784434,
-0.040675085,
0.016078096,
-0.009853257,
0.0100110145,
0.0056694024,
0.005294729,
-0.014211302,
-0.037888043,
0.011621453,
-0.004358045,
0.019325268,
-0.04269964,
-0.008847554,
0.026976496,
0.0034838067,
0.00071565935,
-0.014040398,
-0.0076512285,
0.018970313,
-0.0033819217,
-0.00792073,
0.02259873,
-0.052454296,
-0.014250741,
0.03331308,
0.0056891222,
0.0067901365,
-0.041279823,
0.027423475,
-0.009274813,
-0.03549539,
-0.027765281,
0.025346337,
-0.009518023,
-0.008196806,
-0.027370889,
0.011010144,
0.027607525,
0.011483416,
0.03239283,
-0.010852386,
-0.027975624,
0.011536001,
-0.021836238,
-0.0115425745,
-0.0027065233,
0.003657997
] |
An open reading frame (ORF) with homology to interleukin-10 (IL-10) has been identified in rhesus cytomegalovirus (RhCMV). The IL-10-like protein is generated from a multispliced, polyadenylated early gene transcript encompassing part of the corresponding UL111A ORF of human CMV (HCMV). Immunological analyses confirm expression of the IL-10-like protein both in tissue culture and in RhCMV-infected rhesus macaques. Conserved ORFs were subsequently identified in human, baboon, and African green monkey CM | [
-0.03254755,
-0.026883699,
-0.044710465,
-0.028162632,
0.0030374664,
0.011967162,
-0.0103228185,
-0.0067861765,
-0.027484015,
-0.0077453763,
0.025487313,
-0.0075169955,
-0.0013335815,
-0.016469529,
-0.019706013,
0.0013743639,
0.021115448,
0.0014812135,
-0.020554285,
0.0031255563,
-0.0384724,
0.018596733,
0.00072959554,
-0.023255704,
0.0021076298,
0.020097522,
0.012756707,
-0.03262585,
-0.0055137686,
-0.015960565,
0.005213611,
-0.011040587,
-0.0026100678,
0.0067078746,
-0.005543132,
-0.016678333,
0.023138251,
-0.0075822473,
0.016952392,
-0.006215224,
0.019001294,
0.035314217,
-0.0016639183,
-0.025226306,
0.005817189,
-0.010557724,
0.019131798,
-0.026857598,
-0.02962427,
0.01618242,
0.007608348,
0.030276788,
-0.010081387,
0.0037911236,
-0.012273844,
0.0038726882,
0.015686508,
-0.003986879,
0.011040587,
-0.0538196,
-0.011503874,
-0.00086947886,
-0.020489033,
0.02034548,
0.009422345,
0.040925864,
-0.02616593,
0.013337447,
0.007151586,
0.0008209479,
0.033278365,
0.024143128,
-0.012241218,
0.01619547,
0.022015922,
-0.021011047,
-0.009755129,
0.0006635282,
0.004743798,
-0.016339025,
0.01095576,
-0.042518005,
-0.019340603,
0.02881515,
0.009585475,
-0.021441707,
0.015529904,
0.028188733,
-0.005487668,
-0.022472685,
0.016795786,
0.017983368,
0.023268756,
0.017187297,
-0.01383336,
0.0043555507,
0.010466373,
0.030981505,
0.012613153,
-0.0033310992,
-0.012352146,
0.0023572175,
-0.0131482165,
-0.00088660745,
-0.037141267,
-0.005004805,
0.016769687,
-0.0028090857,
0.022994699,
-0.01136032,
-0.019562459,
0.03575793,
-0.012972037,
-0.03766328,
0.00963115,
-0.0066524106,
0.0173178,
-0.0012471231,
-0.02225083,
0.01038807,
0.025970176,
0.032103837,
-0.00786283,
-0.024521587,
0.028006028,
0.009879107,
-0.0016280299,
-0.014655531,
-0.037141267,
-0.0016704435,
0.028240934,
-0.023764668,
0.01133422,
0.013885561,
-0.017918115,
0.029833077,
-0.018400978,
0.0010105857,
0.0023637428,
-0.012717556,
0.015047042,
0.025839671,
-0.000472667,
0.012025888,
-0.0053734775,
-0.0041761086,
0.013043814,
0.007562672,
0.0048221005,
-0.009709452,
-0.003614944,
-0.027797222,
0.025709169,
0.0012324414,
0.022459634,
0.02617898,
-0.00963115,
0.03163402,
-0.018870791,
-0.013285246,
-0.007138536,
-0.011588701,
0.009069986,
0.020619536,
0.0033735128,
0.009246166,
0.009748603,
0.013572353,
-0.000744685,
0.0086001735,
-0.016821887,
0.020567335,
-0.03891611,
0.020893594,
-0.0060064187,
0.0172656,
0.0010994911,
0.0147990845,
-0.0038009114,
-0.020267177,
-0.008273915,
0.026857598,
0.01842708,
0.013428799,
-0.025187155,
-0.0012169442,
0.02574832,
-0.011999787,
0.0023066476,
-0.017800663,
0.009350568,
0.01037502,
0.0022250828,
-0.03155572,
-0.64353836,
-0.029389365,
0.0053310636,
-0.00020136267,
-0.009918258,
0.015895313,
0.007608348,
-0.011503874,
-0.022590138,
0.017148146,
-0.012652304,
0.010818731,
0.023908222,
-0.015047042,
-0.020449882,
-0.0384724,
0.0035040162,
-0.013898611,
0.005784563,
-0.0006533326,
-0.020658687,
-0.004815575,
0.0065284325,
0.0045610936,
-0.00864585,
0.00999656,
0.035549123,
-0.027196907,
-0.0173178,
0.04032555,
-0.004825363,
0.014851286,
-0.008561023,
-0.013728957,
0.05261897,
-0.006107559,
-0.017383052,
0.016325975,
0.014929588,
0.012704506,
-0.0053963154,
0.005393053,
0.0008050428,
0.0005501534,
-0.023699416,
0.017539656,
0.004786212,
0.018283525,
0.011575651,
-0.021063248,
0.008619749,
0.0033376242,
-0.008900331,
-0.022263879,
-0.01117109,
0.00067331595,
0.026100678,
-0.030877104,
0.03340887,
-0.0032479032,
-0.021324255,
0.010916609,
0.0067339754,
-0.006065145,
0.0074386937,
-0.019157898,
-0.007151586,
-0.0060879835,
0.019510258,
-0.011034062,
0.01691324,
0.041265175,
-0.0050570066,
0.0021826692,
-0.009389719,
0.031190312,
0.007915031,
-0.00018494778,
0.0065838965,
0.012162916,
0.0014526659,
-0.007804103,
-0.023608064,
0.003464865,
0.0014510346,
-0.015973616,
-0.014303172,
0.010916609,
-0.0024338884,
0.013481,
0.027536217,
-0.004424065,
-0.016391227,
-0.023581963,
-0.025148004,
0.005415891,
-0.000047868238,
0.01692629,
-0.0034616026,
0.0037160842,
0.009063461,
-0.021781016,
-0.015242796,
-0.008202138,
0.016743585,
0.005239711,
-0.032599747,
0.010309768,
0.03656705,
-0.017004592,
-0.01884469,
-0.015334149,
-0.0021337306,
-0.0028824937,
0.018635884,
-0.01880554,
0.008404419,
0.013200418,
0.015686508,
-0.020580385,
0.005194035,
-0.0032071208,
-0.0042870366,
0.020893594,
0.021689665,
0.01961466,
0.005021118,
-0.042439703,
0.0025415537,
-0.010903559,
0.023151303,
-0.013637605,
0.026779296,
-0.020201925,
0.03497491,
0.020619536,
0.050061103,
0.007810628,
-0.0048840893,
-0.026257282,
-0.022433534,
-0.016051918,
-0.006114084,
-0.034452897,
0.0029085944,
-0.008685001,
-0.012998138,
0.011588701,
0.005517031,
-0.010479422,
0.014655531,
-0.024038725,
0.0020179087,
0.00080259587,
-0.0115365,
-0.020293279,
-0.000617852,
-0.029180558,
0.003637782,
-0.012658829,
-0.0016043761,
0.012423923,
-0.0030994557,
0.000054495362,
-0.01040112,
-0.0036769332,
-0.0030195222,
0.00044004113,
-0.0121563915,
-0.027536217,
-0.008228239,
-0.0028139795,
-0.012260794,
0.0045839315,
0.003725872,
0.014264021,
-0.013154742,
-0.013650655,
0.0064631808,
-0.0122673195,
0.0053408514,
0.010916609,
0.009011259,
-0.03544472,
0.02925886,
0.010844832,
0.016208522,
0.03536642,
0.029833077,
0.032156035,
-0.018009469,
0.006169548,
-0.00547788,
0.037506677,
0.022916395,
-0.00905041,
0.006753551,
0.01576481,
0.009578949,
0.021337304,
-0.012958987,
-0.024521587,
-0.0033066298,
-0.010870933,
0.003241378,
-0.03004188,
-0.0046981224,
-0.032886855,
0.0024061564,
-0.0003303367,
0.000031020045,
-0.00566711,
0.0018874053,
0.010629501,
-0.013167793,
0.004221785,
-0.01889689,
0.0024404135,
0.005278862,
-0.024143128,
-0.017095944,
-0.0068710037,
0.018818589,
-0.009141763,
0.0022234516,
0.0036638828,
-0.014498927,
0.02272064,
0.009376669,
-0.015895313,
-0.01880554,
0.001768321,
0.019692963,
0.030302888,
0.0010701278,
-0.010740429,
0.017239498,
-0.022055075,
0.041186873,
0.0076801246,
0.0016076387,
0.00029791478,
0.018596733,
0.000055820787,
0.0016451584,
-0.03891611,
0.017135095,
-0.00055545504,
-0.0032332216,
0.029963579,
-0.014864337,
0.012789332,
-0.0044534286,
0.017539656,
0.004319662,
0.017617958,
0.00022858485,
-0.0026084366,
0.048468962,
0.02769282,
0.0005146728,
-0.011693104,
-0.014642481,
0.003569268,
-0.0055659697,
0.01688714,
0.0012773019,
-0.01773541,
-0.024351934,
-0.0093701435,
-0.014485877,
0.009781229,
0.008371793,
-0.015294998,
0.0016590244,
0.0053245383,
-0.0052331863,
0.022694541,
0.010681703,
0.01154955,
-0.038994413,
-0.025200205,
-0.007301665,
0.009833431,
-0.015934464,
-0.0032903168,
-0.033722077,
0.009598524,
-0.0019118747,
0.03385258,
-0.011151515,
0.02268149,
0.016430378,
-0.009180914,
0.0064272922,
-0.00094696524,
0.03275635,
-0.017748462,
-0.0027960353,
0.013768109,
-0.0087111015,
0.0033996133,
0.0025333972,
-0.014342323,
0.041369576,
-0.00345834,
0.003402876,
-0.01807472,
-0.0052331863,
0.01461638,
0.0027046828,
-0.0036997711,
0.008039009,
-0.010844832,
0.0134418495,
-0.0034159264,
-0.008776354,
0.003582318,
0.007073284,
0.00051671185,
0.0012226537,
-0.026387786,
-0.0007324503,
-0.008423994,
0.0075887726,
0.022068124,
-0.014812135,
0.026570491,
0.0023327481,
0.010720854,
-0.028058229,
-0.022394383,
0.011875809,
-0.017370002,
-0.024299731,
-0.01883164,
0.004534993,
-0.009905208,
0.0122673195,
-0.0041597956,
0.02850194,
-0.03152962,
0.009931308,
0.025513414,
0.00921354,
0.0048514637,
-0.0011370109,
0.021415606,
0.012228168,
-0.01461638,
0.0025170841,
0.026231183,
-0.027431814,
-0.032860756,
-0.0034355018,
0.009768179,
-0.008750252,
-0.0045610936,
0.0008613224,
-0.03387868,
0.009533273,
0.0020260653,
0.011034062,
0.0046165576,
0.024051776,
0.042465806,
0.00004488603,
-0.0033669877,
-0.0022332394,
0.008502296,
-0.026387786,
0.024678191,
-0.0012985087,
-0.03881171,
0.023216553,
-0.020254128,
0.0010162952,
0.0031386067,
-0.0011394578,
0.0051092077,
-0.012645779,
0.013663705,
-0.01999312,
-0.011412522,
-0.024795646,
-0.016965441,
0.007797578,
-0.005582283,
-0.030172385,
-0.019014345,
0.0047405357,
-0.006407717,
-0.01958856,
-0.017461354,
0.014564179,
-0.026648793,
-0.008639324,
0.025917973,
0.009637675,
-0.0019820202,
0.015490753,
-0.027170807,
0.025448162,
0.02187237,
-0.021154601,
-0.0063783536,
0.01693934,
-0.040560454,
-0.0067470255,
0.010733904,
0.0028107169,
-0.0113146445,
-0.021585261,
-0.009422345,
-0.0033164176,
0.00786283,
0.03228654,
0.003898789,
0.000044248805,
0.011301594,
0.013533202,
0.03199943,
-0.0063489904,
-0.03609724,
-0.008508821,
-0.026661843,
-0.01961466,
-0.010335869,
-0.007732326,
0.0069754063,
0.011060162,
0.02272064,
-0.036645353,
-0.019497206,
0.021259002,
-0.008541447,
0.003960778,
0.012352146,
0.019745164,
0.009859531,
-0.0061825984,
0.004825363,
0.021820167,
-0.03959473,
-0.009272266,
-0.0192623,
0.022603188,
0.0019706013,
-0.004534993,
0.019053496,
0.018113872,
0.0073669166,
-0.011804032,
-0.016117169,
-0.012932886,
0.032808553,
0.030433392,
-0.01768321,
-0.016808838,
-0.024834797,
-0.00029179742,
0.0013817047,
-0.005145096,
-0.010538149,
0.011967162,
-0.0039575156,
-0.00065577956,
0.0076735998,
0.0014763196,
-0.030694399,
0.0138072595,
0.025461212,
0.0022887033,
0.012978562,
0.0012732238,
0.00088987005,
-0.016952392,
0.008221714,
-0.01769626,
-0.019327553,
-0.00014834566,
-0.015086193,
0.04275291,
0.013017714,
0.04348373,
-0.022746742,
0.0063489904,
0.008750252,
0.023634166,
-0.0052070855,
0.00047959998,
-0.012260794,
-0.01847928,
-0.012906786,
0.021402556,
-0.00864585,
0.0010994911,
-0.017148146,
0.009278791,
0.015229746,
-0.0015325992,
-0.026035428,
-0.009500647,
-0.0151644945,
-0.022237778,
0.019484157,
-0.020162774,
0.0035921058,
-0.024077876,
-0.0043131374,
0.025161054,
0.019379754,
0.0153471995,
-0.015060091,
0.0028971753,
-0.01248265,
0.025970176,
-0.022002872,
0.01056425,
-0.0033310992,
0.016051918,
0.00094288704,
0.019575508,
0.034400694,
0.013885561,
-0.00083929993,
0.027979927,
-0.0017079632,
0.0093701435,
0.015830062,
-0.0192362,
-0.010479422,
-0.016717484,
-0.0046263454,
-0.018361827,
-0.045519583,
0.0033767754,
-0.044840965,
0.0027519902,
0.007999858,
-0.015660407,
0.012143341,
-0.006358778,
-0.020045321,
0.0460677,
-0.00225934,
0.03544472,
-0.018296575,
0.0046035075,
0.011784457,
-0.0012185754,
-0.033643775,
-0.018688086,
0.010857882,
0.004502367,
0.032156035,
0.030094083,
0.007262514,
-0.010629501,
0.034113586,
-0.003202227,
-0.009670301,
-0.029702572,
0.018035568,
0.01581701,
0.014381474,
-0.0036247317,
-0.006962356,
-0.02153306,
0.028606344,
0.0074843694,
-0.00432945,
-0.008619749,
-0.01769626,
-0.018192174,
-0.00045553842,
-0.011347271,
0.019144848,
-0.0030472542,
-0.035784032,
-0.005830239,
-0.026348636,
-0.0018564108,
0.007223363,
0.0006928915,
0.030015782,
0.0109492345,
-0.016769687,
0.0029461142,
-0.018570634,
0.01653478,
-0.0059607425,
-0.020932745,
0.035575226,
-0.00942887,
0.0071842116,
0.0029037006,
-0.0022267143,
0.0015334149,
-0.004959129,
0.014355374,
0.0055235564,
-0.017474404,
0.002058691,
0.034400694,
0.024534639,
-0.0071711615,
0.02766672,
-0.023177402,
-0.0016631027,
-0.048677765,
-0.030981505,
-0.008717626,
-0.042831212,
-0.0017617958,
-0.00095430604,
0.026231183,
0.027901625,
0.031660125,
0.015790911,
0.0071320105,
0.039699133,
-0.033695977,
0.010459847,
0.0066687237,
-0.0002204284,
-0.013017714,
-0.011184141,
0.0013237938,
-0.033722077,
0.01999312,
-0.01958856,
-0.029493768,
-0.014890437,
0.001397202,
0.0035921058,
-0.0071581113,
-0.032912955,
0.020645637,
0.0032837917,
0.014459776,
0.0053702146,
-0.01461638,
0.028475842,
-0.011458198,
-0.026687944,
0.024130078,
-0.0056540594,
-0.014381474,
0.020541234,
-0.012593578,
0.0070993844,
-0.021728816,
-0.024469387,
0.005350639,
0.016273774,
0.010094438,
-0.0033441496,
-0.017069845,
-0.0063065765,
-0.021702714,
0.009924783,
-0.0031027182,
-0.01499484,
-0.017787613,
0.010897034,
-0.0026100678,
0.0036116815,
-0.01808777,
-0.0006749472,
0.015360249,
-0.023386208,
-0.022420483,
-0.01136032,
-0.02150696,
0.029076157,
-0.0045545683,
-0.004469741,
-0.028919552,
-0.011993262,
-0.043588135,
-0.019771265,
0.019249251,
0.02615288,
0.0057029985,
0.010485948,
0.0017112257,
-0.008052059,
-0.02230303,
0.0024648828,
-0.011875809,
-0.014133518,
0.010857882,
0.0062347995,
0.030929305,
0.014159618,
-0.0077388515,
0.0038204868,
0.03500101,
0.012038938,
-0.0062119616,
0.041291274,
-0.009461496,
0.009898682,
-0.02033243,
0.015673459,
-0.012613153,
-0.0060618827,
0.020358529,
-0.02116765,
-0.019405855,
0.021350356,
-0.0015660407,
0.013467951,
-0.008946008,
-0.016495628,
0.010094438,
0.011640903,
-0.0064468677,
-0.019849567,
0.003983616,
-0.01076653,
0.023255704,
0.032338742,
-0.00025162686,
-0.0090765115,
-0.018949093,
0.0012299945,
-0.003464865,
0.010035711,
0.009729028,
-0.01572566,
0.028188733,
0.014733833,
-0.012521801,
0.022211678,
0.014812135,
-0.013128641,
-0.0123782465,
0.007621398,
0.018818589,
-0.030537793,
-0.009833431,
0.0124957,
-0.005311488,
-0.014381474,
-0.0068318527,
0.007073284,
-0.01725255,
0.004094544,
-0.013702856,
-0.013781158,
-0.026374737,
0.016495628,
-0.028345337,
-0.018022519,
-0.024704292,
-0.020306328,
-0.011034062,
-0.0038237495,
0.18677646,
-0.004629608,
-0.011053638,
0.0077910526,
-0.004179371,
-0.0028629182,
0.01730475,
-0.00982038,
0.0030162598,
0.013742007,
0.021024097,
-0.01614327,
0.0044925795,
-0.0037128215,
-0.014511977,
-0.011223292,
-0.014838236,
0.0011019381,
-0.024443286,
-0.016260723,
-0.0052886503,
-0.00568016,
0.0059313793,
-0.012143341,
0.04267461,
0.009859531,
-0.04272681,
0.014446726,
0.0029151195,
0.014472826,
-0.04450166,
0.012534851,
-0.021624412,
0.028188733,
0.0061108214,
0.023542812,
-0.013030764,
-0.0042250473,
0.014107417,
-0.0058269766,
-0.0040814937,
0.0058106636,
-0.020084472,
-0.0041858964,
0.002531766,
0.021833219,
0.0036116815,
-0.015895313,
-0.004756849,
-0.0017748461,
-0.014290121,
0.019353654,
0.020893594,
0.019353654,
0.025709169,
-0.010844832,
0.010329343,
0.020201925,
-0.023673316,
0.004088019,
-0.012091139,
0.020528184,
-0.024469387,
0.013357023,
-0.011621327,
0.03155572,
-0.015699558,
0.0005929748,
-0.009833431,
-0.039438125,
0.017200347,
-0.0015693033,
-0.0039020516,
-0.010825257,
-0.014185719,
-0.015294998,
0.010701278,
0.020893594,
0.017513556,
0.017200347,
-0.0192623,
-0.0015660407,
-0.028423639,
0.010688228,
-0.00058889657,
-0.03004188,
0.03226044,
0.011693104,
-0.01618242,
-0.004714435,
0.023112152,
-0.016639182,
-0.016978491,
0.007947656,
0.026439987,
-0.02388212,
-0.016704435,
0.005585545,
-0.0021891946,
-0.02081529,
-0.02153306,
0.050504815,
0.022446584,
-0.0071842116,
-0.015542954,
0.007856305,
-0.008358742,
-0.002314804,
0.009304892,
-0.025187155,
0.012476125,
-0.025839671,
-0.0015391244,
-0.0052201357,
0.019849567,
0.011079738,
0.00016628987,
-0.019131798,
0.0039281524,
0.006192386,
0.0016769686,
-0.021794068,
-0.0047894744,
0.018400978,
-0.009259216,
0.008574073,
-0.016169371,
0.009063461,
0.001530968,
-0.030250687,
0.012189017,
-0.0043555507,
0.01609107,
0.016078018,
0.020893594,
0.0044827918,
0.007999858,
-0.004375126,
-0.018949093,
0.0020407469,
-0.01964076,
-0.005455042,
0.018609785,
-0.0132591445,
0.005941167,
-0.00384985,
0.024926148,
0.024077876,
-0.012234693,
-0.009833431,
-0.014707733,
-0.032834653,
-0.0027291523,
-0.007921556,
0.012345621,
-0.019301452,
-0.012665355,
-0.022825044,
-0.019666862,
-0.00026895935,
-0.030067982,
0.0069427807,
0.025343759,
-0.028371438,
-0.01384641,
-0.0015024203,
-0.16380785,
0.00038049897,
-0.010035711,
-0.029676473,
0.022198627,
0.037402272,
0.007901981,
-0.010557724,
0.007458269,
0.012058513,
0.04337933,
0.0055594444,
-0.04849506,
-0.011216767,
-0.011229817,
-0.0005941983,
-0.024443286,
0.024025675,
0.025474263,
0.0024502012,
0.034191888,
-0.037167367,
0.015190595,
-0.018922992,
0.011529975,
0.016821887,
-0.007647499,
0.010446797,
0.0024958774,
-0.02659659,
0.003151657,
0.01883164,
0.032103837,
-0.014772984,
0.012887211,
-0.011027537,
0.029833077,
0.004675284,
-0.00844357,
0.013911662,
0.022133376,
0.014459776,
0.0036606202,
0.018283525,
-0.007001507,
0.03815919,
0.023334008,
-0.010074862,
0.011086264,
0.0025480788,
0.027484015,
-0.031477418,
0.021689665,
0.0011671897,
0.0029738462,
0.018257424,
0.0015766441,
0.009729028,
0.00292817,
-0.009905208,
-0.02384297,
-0.009774704,
0.016613083,
-0.009513698,
0.028371438,
-0.025552565,
-0.014368423,
0.027144706,
-0.013611504,
-0.00013407184,
-0.020789191,
0.0050667943,
0.025291558,
-0.009220065,
0.0075887726,
0.02384297,
-0.016795786,
0.034687802,
0.0053734775,
0.0032919482,
-0.0047274856,
0.011751831,
-0.023816869,
0.0001332562,
-0.016012767,
0.008410944,
-0.004101069,
0.019066546,
0.00038865543,
-0.008358742,
0.00412717,
-0.01425097,
0.0006325336,
-0.019301452,
0.026309485,
0.034191888,
-0.0029037006,
0.00284008,
-0.009892157,
0.014498927,
0.020971896,
-0.018531483,
-0.017996417,
-0.002716102,
0.030511694,
-0.02152001,
-0.027562317,
0.0036899834,
0.03152962,
-0.007797578,
-0.0067209247,
0.0066621983,
0.00585634,
0.033173963,
-0.0013727326,
0.028580243,
-0.025722219,
-0.0088938065,
0.007856305,
-0.025643917,
0.06478188,
0.010636027,
-0.010642552,
0.004534993,
-0.04306612,
-0.0155690545,
-0.12215117,
-0.020228026,
0.0072103124,
-0.0103228185,
-0.0249653,
0.020515133,
-0.007849779,
0.02077614,
-0.017826764,
0.011810557,
-0.027797222,
-0.014146568,
0.013650655,
0.015477703,
0.009056936,
0.00045839316,
0.005817189,
-0.0027095766,
-0.035131514,
0.023320956,
0.026753196,
-0.0019983333,
-0.008332642,
-0.0036475698,
0.01773541,
0.011751831,
-0.037741583,
0.014890437,
0.024691243,
0.017604908,
0.02732741,
-0.007549621,
0.022811994,
0.0017617958,
-0.029650372,
-0.017813714,
-0.033904783,
-0.009918258,
0.038315795,
-0.006404454,
0.004854726,
0.015869213,
-0.0006786176,
-0.018153023,
0.029284962,
-0.0051679346,
-0.017448304,
0.010805681,
0.008606699,
-0.017996417,
-0.023360107,
-0.015634306,
-0.052906077,
-0.017422203,
0.006570846,
-0.026583541,
0.02495225,
0.020789191,
-0.019927869,
-0.009409294,
0.0042544105,
0.010733904,
0.00060031563,
0.015425501,
0.013193893,
-0.012352146,
0.012404348,
-0.028945653,
0.03351327,
-0.029859176,
0.00020666436,
-0.0015529904,
-0.008652375,
-0.04374474,
-0.0015660407,
0.010453322,
-0.023986524,
-0.027196907,
0.009533273,
-0.019105697,
-0.021846268,
-0.027510116,
0.026309485,
0.010492473,
0.0020489034,
0.033173963,
-0.00019810007,
-0.0061989115,
0.0037226093,
-0.011660478,
-0.0016867564,
0.053271487,
-0.0071581113,
-0.012658829,
-0.010074862,
0.014498927,
-0.01656088,
-0.0104337465,
0.022564037,
0.01884469,
-0.01806167,
-0.018753339,
-0.06854038,
0.011804032,
-0.0061434475,
-0.0024942462,
-0.0030227848,
-0.018949093,
-0.004156533,
-0.010309768,
0.01807472,
0.03387868,
-0.022368282,
0.028710747,
-0.015699558,
0.03870731,
-0.0138072595,
0.022015922,
0.02225083,
-0.004825363,
0.026583541,
0.017878965,
-0.00054485165,
-0.003363725,
0.00826739,
0.036253843,
-0.010342394,
0.0042576734,
-0.007836729,
0.034557298,
-0.017513556,
-0.002455095,
-0.0045219427,
-0.038759507,
-0.01885774,
0.030589996,
-0.011595227,
-0.022237778,
-0.00451868,
0.022811994,
0.0038204868,
0.027927727,
-0.018270476,
-0.043562032,
0.018009469,
0.009572424,
0.0042805113,
0.010883983,
-0.03145132,
0.0052723372,
0.0047340104,
-0.0173178,
0.04812965,
0.004760111,
-0.016678333,
-0.052801672,
0.0024224692,
0.020554285,
-0.0058922283,
-0.024378033,
-0.0050798445,
-0.004110857,
0.01650868,
0.007823679,
0.011856234,
0.005712786,
0.0028988067,
0.00586939,
-0.0172656,
0.005813926,
0.011529975,
-0.007908505,
-0.030433392,
0.010714329,
-0.0065675834,
0.02268149,
-0.006074933,
-0.0024387822,
-0.01884469,
0.033722077,
-0.0067209247,
0.0017259074,
0.006593684,
0.0033033672,
-0.009207015,
0.0022789156,
0.0134418495,
0.011047113,
-0.0020211714,
0.030955406,
-0.0054583047,
0.022146426,
-0.0072820894,
0.016286824,
0.007986808,
0.0052755997,
0.012254269,
0.019849567,
-0.018139971,
0.02188542,
0.005663847,
0.037767682,
-0.0037584978,
-0.0075039454,
0.007138536,
-0.026309485,
-0.009207015,
0.006851428,
-0.025891874,
-0.03035509,
-0.013911662,
-0.0074452185,
0.017174246,
-0.0029151195,
0.00921354,
0.0019037182,
-0.02727521,
-0.018205224,
0.00006438507,
-0.011216767,
-0.017448304,
0.020567335,
0.014159618,
0.021715764,
-0.0011908435,
0.005399578,
-0.010048761,
0.017957266,
0.020423781,
-0.0024404135,
0.010936185,
-0.013285246,
-0.0075561465,
0.0029183822,
-0.015608206,
-0.017839814,
-0.013174318,
0.003898789,
0.002097842,
0.0061564976,
0.018557582,
0.072820894,
0.01094271,
-0.016339025,
0.0019608135,
-0.009324468,
0.024795646,
0.012417398,
0.017226448,
-0.015007891,
-0.024391085,
0.021154601,
-0.029598169,
0.030903203,
-0.024025675,
-0.030903203,
0.0016622869,
0.000048887796,
0.012600102,
-0.0071842116,
-0.0003902867,
0.017591858,
-0.01883164,
0.008130361,
0.008241289,
-0.033983085,
0.004580669,
0.027379612,
-0.00461982,
0.0015325992,
-0.03346107,
0.009513698,
0.0017373264,
-0.023621114,
-0.0030162598,
0.004143483,
-0.02225083,
0.010910084,
-0.0075561465,
0.011105839,
0.0071842116,
-0.004414277,
0.00090781425,
-0.003859638,
-0.013702856,
0.0074713193,
-0.016299874,
-0.01692629,
-0.0005574942,
-0.03413969
] |
The Tasmanian devil (Sarcophilus harrisii), the largest marsupial carnivore, is endangered due to a transmissible facial cancer spread by direct transfer of living cancer cells through biting. Here we describe the sequencing, assembly, and annotation of the Tasmanian devil genome and whole-genome sequences for two geographically distant subclones of the cancer. Genomic analysis suggests that the cancer first arose from a female Tasmanian devil and that the clone has subsequently genetically diverged during its spread across Tasmania. The devil cancer genome contains more than 17,000 somatic base substitution mutations and bears the imprint of | [
-0.028654983,
-0.0058463905,
-0.0019109993,
-0.009424929,
-0.022651846,
0.028014649,
-0.025946902,
0.00035727015,
-0.013993984,
-0.010638896,
0.0077974107,
0.02680068,
0.021224432,
-0.012046299,
0.010625556,
0.012153022,
0.028841749,
-0.0020160542,
-0.0012923424,
-0.012606592,
-0.015234633,
0.009211483,
-0.0049692653,
-0.0077040284,
-0.0118728755,
0.03239027,
0.0050393017,
-0.02113105,
-0.02074418,
0.004795841,
0.0047724955,
0.0079908455,
-0.013887262,
-0.0043389355,
-0.021944808,
-0.0017725936,
0.009524981,
-0.030309182,
0.012239734,
-0.029108554,
0.006936961,
0.012760006,
0.0047291396,
-0.01338033,
-0.012719985,
0.0005661294,
-0.008551138,
-0.024799636,
-0.004225543,
-0.0013498726,
0.020477375,
0.009551661,
-0.0018593055,
0.0017992742,
-0.03279048,
-0.017929375,
0.023505624,
-0.0086044995,
0.006630134,
-0.014034005,
0.011732802,
0.0007037013,
-0.0388203,
0.0150878895,
-0.009238164,
-0.0000802503,
0.008044207,
0.006950301,
-0.013160215,
0.005816375,
0.050666496,
0.04007429,
0.001875981,
0.0010705598,
-0.0061899032,
-0.029161915,
-0.016715407,
0.005506213,
-0.0069636414,
0.016768768,
0.027854566,
-0.013627126,
0.013480382,
0.008951347,
0.021197751,
0.011199189,
-0.0027814545,
0.0010080271,
-0.0054595214,
0.020877585,
0.00068952725,
0.00861784,
-0.02459953,
0.020103846,
-0.031990062,
0.007243788,
-0.002678067,
0.028228095,
0.011472666,
-0.046797805,
0.010432121,
-0.0014749379,
0.0009913517,
-0.01423411,
0.0045457105,
0.0032933888,
0.0076573375,
-0.012953441,
-0.008791264,
-0.022571804,
-0.010185326,
0.017088937,
0.003303394,
-0.051867124,
0.0249864,
-0.0051660347,
0.054428462,
0.013767199,
0.010051923,
-0.008958017,
0.03890034,
0.005779689,
0.007937484,
-0.029855613,
0.03401779,
0.007290479,
-0.02287863,
-0.013180225,
0.01511457,
-0.023172118,
0.024332725,
-0.012039629,
0.027267592,
-0.0035752028,
-0.0038086583,
0.018236203,
-0.023612347,
-0.023092074,
0.014180749,
-0.03962072,
0.008817945,
0.03959404,
-0.0053594694,
0.0020777532,
0.0044123074,
0.008471096,
0.017195659,
0.022198275,
0.011759482,
0.0036986007,
0.034257915,
-0.014540937,
-0.00039312223,
-0.017342402,
0.020570757,
-0.0029198602,
-0.016782109,
0.023118757,
-0.013967304,
-0.0124932,
-0.0207175,
0.01596835,
0.0034184542,
0.017449124,
0.0033984438,
0.034417998,
0.013647136,
-0.008998038,
-0.000053517568,
-0.022131573,
0.008597829,
0.027694482,
-0.010598876,
0.039460633,
-0.015861627,
0.012933429,
-0.05218729,
0.021051008,
-0.0096783945,
-0.025693435,
-0.022304997,
0.025920222,
0.04314256,
0.0142207695,
-0.011692781,
-0.012359796,
0.0014115715,
-0.02074418,
0.027080828,
-0.04138164,
0.00045773937,
-0.003039923,
0.025613394,
-0.002071083,
-0.6322239,
-0.014714361,
0.0027531064,
-0.006603453,
-0.009078081,
0.012319775,
0.009178133,
-0.005309443,
-0.018276224,
0.018489668,
-0.008357704,
0.0015966683,
0.01467434,
-0.032577034,
-0.009191473,
-0.019170024,
-0.009665054,
-0.00031995898,
0.007984175,
0.00040458658,
-0.0362056,
0.0066768248,
0.005092663,
-0.0010196998,
-0.0017425779,
0.0046757786,
0.018022757,
-0.036819253,
0.006733521,
0.020077165,
-0.050746538,
0.0025846849,
-0.0067235157,
-0.0014807744,
0.046664402,
-0.018316245,
0.01164609,
0.021277793,
0.021024328,
0.015194613,
-0.014687681,
0.014194089,
0.0006849415,
0.006513406,
-0.036125556,
0.0037819776,
0.022758568,
-0.0061131967,
-0.00731716,
-0.023092074,
0.008057547,
0.0054028253,
-0.020997647,
0.0008183446,
0.011425975,
-0.020063825,
0.040634584,
-0.015314675,
0.000005328307,
0.004822522,
0.0020160542,
0.020183887,
0.018689774,
-0.009211483,
0.00040583723,
0.014194089,
-0.016608685,
0.029908974,
-0.00080750557,
-0.009364897,
0.019943763,
0.029562125,
-0.024132619,
-0.0031783287,
0.030736072,
0.03241695,
0.009018049,
-0.015221293,
0.017515825,
0.00082626543,
0.015648182,
-0.0009246502,
-0.030095737,
0.019583574,
0.020250589,
-0.023025373,
-0.004185522,
0.030922838,
0.007884122,
0.017969396,
0.028841749,
-0.0010030245,
-0.016275177,
-0.027214231,
-0.0017158972,
-0.007824091,
-0.002467957,
-0.013847241,
-0.020544076,
-0.024119278,
0.0038486791,
-0.010278708,
0.034711484,
-0.012426498,
0.052454095,
-0.0013982311,
-0.038340047,
0.004265564,
0.03156317,
-0.016942192,
-0.015995031,
0.008531128,
0.0023829127,
0.013820561,
-0.025680095,
-0.022158254,
0.023839133,
0.015621502,
0.018716455,
-0.040687945,
0.013313629,
0.034151193,
-0.0008671201,
0.006516741,
0.0241593,
0.01895658,
-0.012233064,
-0.021864766,
0.0008016692,
-0.026507195,
-0.0071504056,
-0.00904473,
0.010078603,
-0.019103322,
0.0018509679,
0.018156162,
0.01859639,
0.012553231,
-0.0319367,
0.0058397204,
-0.02503976,
-0.010665577,
0.0057863593,
0.007297149,
-0.010191997,
-0.010652237,
-0.0026197033,
-0.015074549,
-0.006936961,
-0.010332069,
-0.001261493,
-0.00947829,
0.0032983914,
0.004012098,
0.031963382,
0.008684541,
-0.0144742355,
-0.025373269,
0.0061031915,
-0.004759155,
0.007864112,
0.024506148,
-0.025199844,
-0.020464035,
0.0021644651,
-0.0051126736,
0.008664531,
0.03668585,
0.006206579,
-0.040447816,
-0.021064349,
-0.026907403,
0.002346227,
0.00690361,
0.005739668,
0.0022545122,
0.00050651486,
-0.018769816,
-0.02638713,
-0.003755297,
0.0034417997,
-0.014821083,
0.033510856,
-0.00033454993,
0.021891447,
-0.00069703115,
0.010498824,
-0.005172705,
-0.011445985,
0.020383993,
-0.019543553,
0.018262884,
0.014207429,
0.014514256,
0.005649621,
-0.016061733,
0.037859797,
0.017569188,
0.02934868,
0.009585012,
0.000013496641,
-0.024466127,
0.008584489,
-0.0028648314,
0.018943239,
-0.023532305,
-0.010198667,
-0.018316245,
0.014687681,
-0.009344887,
0.022705207,
0.01426079,
-0.0062699453,
0.01937013,
0.0034851558,
0.020037144,
-0.0082976725,
-0.005779689,
0.00040208525,
-0.007003662,
-0.0040354435,
-0.007430552,
0.0100319125,
-0.009124772,
0.0075973063,
0.006126537,
0.0064600445,
0.018903218,
-0.022985352,
-0.008250982,
-0.0041154856,
-0.012399818,
-0.0026864049,
0.0023362217,
0.02926864,
-0.029055193,
-0.0074905837,
-0.004275569,
0.03535182,
0.0037419568,
-0.014354173,
0.00775739,
0.019343449,
-0.008964688,
0.027254252,
0.009731756,
0.008077557,
-0.008717892,
-0.006560097,
0.01075896,
-0.0033817685,
-0.0042522238,
-0.021384515,
0.014167408,
0.0017409103,
-0.019250067,
0.019570233,
0.028441539,
0.030335864,
-0.013820561,
0.012880068,
-0.00094132556,
0.0025313236,
-0.0019160019,
0.007117055,
-0.002226164,
-0.008491107,
-0.0038620196,
0.018262884,
0.00030411736,
-0.0021678002,
0.0035518573,
0.013440361,
-0.039967567,
0.009091421,
0.018156162,
-0.033324093,
0.027481036,
0.00019947931,
0.00731716,
-0.004018768,
-0.053254515,
0.0021244443,
-0.001521629,
0.002281193,
-0.008971358,
0.011952917,
0.00089880335,
-0.021411195,
0.025653414,
0.021437878,
0.030575989,
-0.01079231,
0.006943631,
-0.0042155376,
-0.014554277,
0.013527074,
-0.024212662,
-0.0024262688,
0.024959719,
0.000011477356,
-0.0077106985,
-0.0028381508,
-0.013053493,
0.03876694,
0.00670017,
-0.018689774,
-0.0053728097,
-0.029402042,
-0.01594167,
0.0012264746,
-0.022118233,
-0.01591499,
-0.01076563,
-0.012646613,
0.018236203,
0.0064633796,
0.0015024523,
0.023185458,
-0.003451805,
-0.014661,
-0.022398379,
-0.014207429,
-0.024852997,
0.070917085,
0.028228095,
-0.003253368,
0.008744572,
0.014314151,
0.0013632128,
-0.001630019,
-0.024519488,
0.012206383,
-0.02458619,
0.0041154856,
0.0044690035,
0.0047658253,
0.020023804,
-0.00050443044,
0.009338217,
-0.0074038715,
-0.0189966,
-0.02075752,
0.008571149,
0.0002738932,
-0.008070887,
0.013173555,
0.039513994,
0.018889878,
-0.02804133,
0.019476851,
0.022371698,
0.0014482574,
-0.024546169,
-0.018022757,
0.00733717,
-0.010038583,
0.03185666,
0.019316768,
-0.0060231495,
0.008958017,
0.013280278,
0.018769816,
0.0095716715,
0.021931468,
0.017342402,
0.01550144,
-0.012626602,
0.017075596,
0.007563955,
-0.0063299765,
0.0034651454,
0.007130395,
-0.027254252,
0.05277426,
-0.023225479,
-0.006556762,
-0.01767591,
0.023612347,
0.0100319125,
-0.01165276,
0.0067168456,
-0.020130526,
0.017449124,
-0.012166362,
-0.011452655,
-0.014741042,
-0.007890793,
-0.007030343,
-0.006560097,
-0.01762255,
0.009965211,
-0.026707299,
-0.014794403,
0.019156683,
-0.030922838,
0.0067035053,
-0.02637379,
0.014821083,
-0.010292049,
0.009344887,
-0.011992938,
0.025199844,
0.033377454,
-0.005065982,
0.004005428,
-0.01726236,
-0.017128957,
-0.0037352866,
0.008324353,
0.036872614,
-0.03745959,
-0.019490192,
0.019703636,
0.002909855,
0.014847764,
-0.011272562,
-0.008851295,
-0.0067268508,
0.020850902,
0.004238883,
0.038260005,
-0.021277793,
0.000109744884,
0.005432841,
-0.032843843,
-0.039167147,
0.0020827558,
0.008671201,
-0.019650275,
0.004995946,
0.012166362,
-0.03367094,
-0.03497829,
0.0198237,
-0.012960111,
-0.007290479,
-0.012419828,
0.02680068,
0.006179898,
0.001391561,
-0.002309541,
-0.0026130332,
-0.0040787994,
0.012159692,
-0.005519553,
0.0030282503,
0.01682213,
-0.0064867255,
0.023652367,
0.0028248106,
-0.023438923,
-0.013220247,
-0.031403087,
0.037886478,
0.012873398,
0.0053694746,
-0.04517029,
-0.00777073,
0.0022678527,
0.01551478,
0.013740518,
-0.009785117,
-0.027747843,
-0.015981691,
0.0034284594,
-0.0033984438,
0.0015533123,
0.0057163225,
-0.030896157,
-0.011699451,
0.013140204,
0.046531,
-0.0033334098,
-0.022038192,
-0.015354696,
0.0068369084,
-0.0029198602,
0.0025863524,
0.004398967,
-0.020197228,
0.00518938,
0.030442586,
0.013213576,
0.022024851,
-0.016622026,
0.016048392,
0.02501308,
-0.005122679,
0.0006657648,
-0.00057488395,
0.00495259,
-0.023425583,
0.0095716715,
0.013433691,
0.04517029,
-0.0050326316,
-0.009858488,
0.02977557,
0.0029448732,
-0.0014424209,
-0.013967304,
0.0015157927,
-0.03279048,
-0.018022757,
0.007684018,
-0.006209914,
0.017088937,
-0.03535182,
-0.0023428919,
0.036312323,
0.034177873,
-0.0013115192,
-0.0020510724,
0.016795449,
0.0044156425,
0.027961288,
-0.0028564937,
0.01252655,
-0.0025646745,
-0.03409783,
0.0018226197,
-0.013440361,
-0.003498496,
-0.016622026,
0.0024412766,
0.025906881,
-0.02370573,
-0.0011305913,
-0.0026864049,
-0.0044189775,
0.0018376276,
-0.0014282468,
-0.01687549,
-0.022558464,
-0.03105624,
-0.019690296,
-0.03887366,
0.019570233,
-0.004579061,
-0.03102956,
0.010905703,
0.00031787457,
-0.023065394,
0.0041588414,
0.0016708737,
0.032923885,
-0.003371763,
0.039834164,
0.016501963,
-0.027240911,
-0.024025897,
0.008584489,
0.01510123,
0.0036852604,
0.01588831,
0.015768245,
0.0040754643,
0.0018659758,
0.031296365,
0.0011039106,
-0.03535182,
-0.050159562,
0.017782632,
-0.010572195,
0.012813367,
-0.021331154,
-0.0051160087,
-0.010065263,
-0.005562909,
-0.028254775,
0.014180749,
-0.0073571806,
-0.049732674,
-0.022078212,
-0.00014851516,
-0.013293618,
0.018422967,
-0.0008879643,
0.006436699,
-0.0054161656,
-0.019343449,
-0.019716976,
-0.0023245488,
-0.013673817,
0.016955532,
-0.015741564,
0.0018726459,
-0.0057863593,
-0.018342925,
0.012980121,
0.005869736,
0.0041121505,
0.041648444,
-0.023038713,
0.0064200237,
-0.014060686,
-0.006390008,
-0.017782632,
0.021357834,
-0.0006282452,
-0.008524458,
-0.032897204,
0.005085993,
0.027374314,
0.023599006,
0.010939053,
-0.03145645,
-0.0071437354,
-0.0125865815,
-0.053387918,
-0.01424745,
-0.0064733853,
-0.020890925,
-0.018049438,
0.0035618625,
-0.010232017,
0.022718547,
0.017155638,
-0.006876929,
0.0044223126,
0.04010097,
-0.008344363,
0.02756108,
0.0029815591,
0.011032436,
-0.018703114,
0.003278381,
0.014701021,
-0.027774524,
0.00088963186,
-0.011699451,
-0.007463903,
-0.02501308,
-0.017555848,
0.015741564,
-0.018196182,
-0.00041000606,
0.029402042,
0.004482344,
0.03930055,
-0.009338217,
-0.025586713,
0.008050877,
0.00865119,
0.0020377322,
-0.0011372614,
-0.008991368,
0.0021928134,
-0.008531128,
-0.006199909,
-0.007824091,
-0.002186143,
-0.025479991,
-0.027774524,
-0.004125491,
0.020784201,
-0.009311535,
-0.013833901,
0.002309541,
-0.011279232,
0.0041521713,
0.0045557157,
-0.022998692,
-0.006116532,
0.01811614,
-0.015981691,
0.0017825988,
-0.018916558,
-0.007210437,
-0.019917082,
-0.011959587,
-0.03577871,
-0.008417735,
-0.030842794,
0.011892886,
0.018142821,
-0.0029832267,
-0.033377454,
0.0028815067,
-0.050266284,
-0.01251321,
-0.0018376276,
0.021411195,
0.009091421,
0.027427675,
0.006303296,
0.016008371,
0.004398967,
0.021878107,
0.003058266,
-0.018823177,
0.009651714,
0.0026147007,
0.020677479,
0.017329061,
-0.044289827,
-0.008771254,
0.021411195,
-0.0048425323,
-0.030736072,
0.005512883,
-0.031189643,
-0.005913092,
-0.022318337,
0.005639616,
0.0011114145,
0.013440361,
0.0077106985,
0.018529689,
-0.027040808,
-0.010925713,
0.002693075,
0.00268974,
0.007957495,
0.003968742,
0.018236203,
0.02070416,
-0.0041221557,
-0.019663615,
-0.005689642,
-0.0034317945,
-0.00731716,
0.016635366,
0.0090647405,
0.021371175,
-0.011752812,
-0.022571804,
0.0085044475,
0.009798457,
-0.032630395,
-0.01076563,
0.0064733853,
-0.02331886,
0.007897463,
-0.0051993853,
-0.017168978,
-0.02110437,
0.009351557,
-0.010525504,
-0.014554277,
-0.04364949,
0.047731627,
-0.006333312,
-0.016795449,
-0.02886843,
0.010585535,
-0.015421397,
0.0042955796,
-0.017088937,
0.001969363,
0.007117055,
0.023812452,
-0.016928852,
-0.020450694,
-0.025159823,
-0.016795449,
0.006380003,
-0.025653414,
-0.0038320038,
0.18932568,
-0.01588831,
-0.005682972,
0.046664402,
-0.020637458,
0.011486006,
0.037779756,
-0.009751766,
-0.018823177,
0.008471096,
0.033804342,
0.0035151716,
0.004559051,
0.010825661,
0.020130526,
-0.011579389,
-0.03575203,
-0.005059312,
-0.0023612347,
-0.048025113,
0.015314675,
-0.020464035,
-0.008657861,
0.004018768,
0.017956056,
-0.012133012,
-0.030976199,
-0.032123465,
0.0012173032,
0.007810751,
-0.037352867,
-0.0061398773,
-0.008864636,
0.018903218,
-0.019089982,
0.01595501,
-0.022131573,
0.0038253337,
0.008791264,
0.0024879677,
-0.008904656,
-0.0072637983,
-0.014981167,
-0.019476851,
-0.0130468225,
-0.003491826,
-0.00775739,
-0.0097784465,
-0.009578342,
0.0022428394,
-0.032230187,
0.01467434,
0.0154480785,
-0.0027164205,
-0.002186143,
-0.0033634254,
0.050746538,
-0.0051493593,
0.019130003,
0.02499974,
-0.020063825,
0.01977034,
0.00017967728,
0.015408057,
-0.014420874,
0.018209523,
-0.020370653,
0.01941015,
0.011726132,
-0.028761707,
-0.009585012,
-0.040767986,
-0.029028513,
-0.00041792687,
0.005082658,
-0.0029532108,
0.021838086,
0.0024712924,
0.022972012,
0.0154480785,
0.0007637327,
-0.01590165,
0.000026498232,
-0.0016767101,
-0.0036318991,
-0.03236359,
0.029722208,
0.0012464852,
-0.0150878895,
-0.0009946869,
-0.0038953703,
0.0071704164,
0.016101753,
-0.015808266,
0.014047345,
0.033404134,
0.010859012,
0.0067235157,
-0.0005077655,
-0.018396286,
-0.04183521,
0.022104893,
0.011739472,
0.0091647925,
-0.0027230906,
0.005883076,
-0.006503401,
0.014540937,
0.026934084,
-0.03711274,
-0.012613262,
-0.021678003,
0.0011872875,
-0.0094716195,
0.022665186,
0.0337243,
0.0041655116,
-0.008844625,
0.008137588,
0.013467042,
0.018729795,
-0.017795973,
0.020183887,
0.013927283,
-0.011946247,
-0.032523673,
-0.03807324,
0.0003516422,
0.0150878895,
-0.022131573,
0.0016925518,
-0.022718547,
-0.012459849,
0.026907403,
-0.00010901534,
0.00216113,
-0.0020777532,
-0.034898248,
-0.020984307,
0.0030265828,
0.0003535182,
0.016955532,
0.0104921535,
-0.0030482607,
-0.027000787,
-0.019743657,
0.030736072,
-0.0073305,
-0.019943763,
-0.019583574,
-0.021824745,
-0.023945855,
0.0015733227,
-0.00776406,
0.03495161,
-0.024959719,
-0.011012426,
-0.04236882,
-0.019610254,
-0.011072457,
-0.043382686,
-0.0007995848,
0.019236727,
-0.024346065,
-0.009971881,
0.005139354,
-0.16851479,
0.0069703115,
0.023879154,
-0.041328277,
0.032843843,
-0.004739145,
0.017515825,
0.0038119934,
-0.0019109993,
-0.010939053,
0.058644,
0.0026197033,
-0.016648706,
-0.01590165,
-0.008511118,
-0.0013140205,
-0.010038583,
0.020917606,
0.014274131,
0.0017742611,
0.020077165,
-0.013927283,
-0.004619082,
-0.031749938,
-0.00084294076,
0.01979702,
0.010318729,
-0.0029148576,
-0.008804604,
-0.003451805,
-0.0129467705,
-0.009464949,
0.00947829,
-0.03505833,
0.0069236206,
-0.006186568,
-0.015047869,
-0.022985352,
-0.011299242,
-0.0037252815,
0.01121253,
0.02717421,
-0.0039520664,
-0.011119148,
-0.000060239832,
-0.0014065688,
-0.006600118,
-0.0014991172,
0.02926864,
-0.016088413,
0.019103322,
0.0117194615,
0.014941147,
0.009191473,
0.0153947165,
0.0115660485,
0.029375361,
0.014060686,
0.0041054804,
-0.005062647,
-0.005649621,
-0.009304865,
0.018076118,
-0.006213249,
0.018409627,
-0.052907668,
-0.030069057,
0.018462988,
-0.026520535,
0.017329061,
-0.033297412,
0.013126864,
0.005382815,
-0.0056329453,
0.013820561,
-0.01123921,
-0.03191002,
0.0070970445,
-0.020410674,
-0.023345541,
0.0028681664,
0.030042376,
-0.010232017,
-0.027907927,
0.0046024066,
-0.014861104,
-0.014821083,
-0.0032900537,
0.03407115,
0.008884646,
-0.008277662,
-0.033884384,
0.0012815035,
-0.025146483,
0.029562125,
0.015781585,
-0.00024450285,
0.002002714,
0.007190427,
-0.019330109,
0.0039854175,
-0.00819762,
-0.0018276224,
0.033083968,
0.006066506,
0.02542663,
-0.0060598357,
0.014327492,
0.024306044,
0.009865158,
-0.014794403,
-0.0029498758,
0.0070503536,
0.0025313236,
-0.003169991,
0.03281716,
-0.009324877,
-0.018663093,
0.020050485,
-0.010839001,
0.04367617,
0.004825857,
0.020837562,
0.016782109,
0.020517396,
-0.029668847,
-0.11003087,
-0.01941015,
-0.007897463,
0.024506148,
-0.01682213,
0.03575203,
-0.00334675,
0.026960764,
-0.034898248,
0.029455403,
0.0074905837,
-0.025213184,
0.011132488,
0.0054528513,
0.021010987,
-0.0112058595,
0.0050759874,
-0.0012097993,
-0.0065867775,
0.021037668,
0.0051960503,
0.0015766578,
-0.007984175,
-0.024279363,
-0.0036052186,
0.00990518,
-0.017755952,
0.019250067,
0.010091944,
0.013560425,
0.012906749,
-0.009718415,
-0.003885365,
0.0041054804,
-0.013727178,
-0.00036248122,
-0.012426498,
-0.028334817,
0.028441539,
-0.009404918,
-0.01467434,
0.020077165,
0.015354696,
0.00862451,
-0.0024095934,
-0.025666755,
-0.011772823,
0.015314675,
0.0010322065,
-0.036472406,
-0.017382422,
-0.0016275177,
-0.022358358,
0.004442323,
0.013993984,
-0.022598485,
0.0030549308,
0.0042455536,
0.007070364,
0.011832855,
0.00988517,
0.009805127,
0.007030343,
0.013420351,
-0.0032583706,
-0.012706645,
0.002006049,
-0.0045090243,
0.00904473,
-0.051093385,
0.0077240393,
0.015608162,
-0.0057596783,
-0.03457808,
-0.02327884,
0.00366525,
-0.01034541,
0.010592205,
0.009211483,
-0.0032667082,
-0.0039554015,
-0.008531128,
0.024426106,
0.008824615,
0.038660217,
-0.007924143,
-0.011806173,
-0.009658384,
-0.014901126,
-0.0051460243,
-0.0050993334,
0.04180853,
-0.011946247,
-0.019103322,
-0.017782632,
0.012880068,
-0.010839001,
0.016702067,
0.013660477,
0.021878107,
-0.02457285,
0.0019910412,
-0.06867591,
0.01686215,
0.0036352342,
-0.013020142,
0.01336032,
-0.004882553,
-0.004929244,
-0.010212007,
0.004182187,
0.013427021,
-0.012459849,
0.013940623,
-0.018462988,
-0.001640858,
-0.020477375,
-0.008524458,
-0.011826184,
0.0054195006,
0.012012948,
0.041114833,
0.009004708,
0.008597829,
0.011959587,
0.025613394,
0.012726655,
0.0116661005,
0.024933038,
0.03324405,
-0.0092648445,
-0.0018159496,
0.0017625884,
-0.002201151,
0.0029298654,
0.0057096523,
0.0011080795,
-0.0241593,
0.009958541,
0.006740191,
0.010058593,
0.04877217,
-0.009138112,
-0.018716455,
0.01900994,
-0.02073084,
-0.0003643572,
0.008591159,
-0.0044189775,
0.0019927088,
0.031990062,
0.031109601,
0.030042376,
0.0008512785,
-0.010212007,
-0.025546692,
-0.030069057,
-0.011672771,
0.010932383,
0.0052160607,
-0.016595345,
-0.00905807,
0.01252655,
0.027280932,
0.013980644,
0.0005127681,
-0.0065300814,
-0.017929375,
-0.014701021,
-0.002309541,
0.016595345,
-0.03404447,
-0.016341878,
0.0011981265,
0.01512791,
-0.0022578472,
-0.0013465375,
-0.012113001,
-0.031189643,
0.014367513,
-0.017155638,
0.0047658253,
0.002569677,
-0.014100707,
0.01762255,
0.01380722,
0.042528905,
0.016928852,
-0.011199189,
-0.0077040284,
0.006069841,
0.01380722,
-0.011832855,
0.014074027,
0.008524458,
0.0013015139,
-0.0025196509,
0.050186243,
0.024893017,
0.0032717108,
0.017128957,
0.01249987,
0.009438269,
0.015981691,
0.002241172,
0.002996567,
-0.00017467467,
-0.012820037,
-0.016115094,
-0.04866545,
-0.00861117,
0.0026847373,
0.01811614,
-0.0034751506,
-0.005396155,
0.0038920352,
-0.012646613,
-0.0036318991,
0.004435653,
0.013713838,
-0.019650275,
0.04959927,
0.0034851558,
0.024306044,
0.011499346,
0.0034584752,
0.0011622744,
0.027507717,
0.015328015,
-0.011866205,
0.007630657,
-0.005823045,
0.005612935,
0.02111771,
-0.013240257,
-0.011792833,
-0.002541329,
0.002476295,
0.017168978,
0.020824222,
-0.01552812,
0.050746538,
0.020664139,
0.011025766,
0.0074772434,
-0.02075752,
0.005506213,
0.044183105,
0.03231023,
-0.0049692653,
-0.002096096,
0.0017392428,
-0.021237772,
0.01208632,
-0.026066964,
-0.017822653,
0.036952656,
-0.011125818,
0.01165276,
-0.02073084,
-0.020263929,
0.003151648,
0.02114439,
0.0014040675,
-0.0052394066,
-0.03022914,
-0.003928721,
0.039807484,
0.015714884,
-0.0043456056,
-0.0172757,
-0.0050326316,
-0.004572391,
-0.030575989,
-0.017155638,
0.016968872,
0.01730238,
-0.014274131,
-0.008030866,
0.025786817,
-0.0026713968,
-0.0035785378,
0.0006224088,
-0.006263275,
-0.006740191,
0.004192192,
-0.010745619,
0.010125294,
-0.018129481,
-0.012973451
] |
Melanomas are highly heterogeneous tumors, but the biological significance of their different subpopulations is not clear. Using the H3K4 demethylase JARID1B (KDM5B/PLU-1/RBP2-H1) as a biomarker, we have characterized a small subpopulation of slow-cycling melanoma cells that cycle with doubling times of >4 weeks within the rapidly proliferating main population. Isolated JARID1B-positive melanoma cells give rise to a highly proliferative progeny. Knockdown of JARID1B leads to an initial acceleration of tumor growth followed by exhaustion | [
-0.030953104,
-0.014430476,
0.00082269474,
-0.024287725,
-0.031730954,
0.004797865,
-0.023402585,
0.0013486661,
-0.032267403,
-0.000023705385,
0.008589889,
0.012251153,
0.012412087,
-0.004455879,
-0.029075531,
0.0065681464,
0.026285997,
-0.0050727953,
0.0021139442,
0.014417065,
-0.02741254,
0.01711272,
-0.009414678,
-0.004442468,
-0.00822108,
0.0438547,
0.0086100055,
-0.0280831,
-0.0023318764,
0.0048548626,
0.01798445,
0.005113029,
-0.006732434,
0.012251153,
-0.006095401,
0.011164843,
0.01255961,
-0.012720545,
0.028887775,
-0.011815288,
0.0070543033,
-0.0019211577,
0.008784351,
-0.03398404,
-0.009495146,
-0.010856385,
0.030979926,
-0.021887116,
-0.0280831,
0.0071884156,
-0.0039160773,
0.0140683735,
-0.008214374,
0.007805332,
-0.010903324,
-0.0017887219,
0.034815535,
0.034708247,
-0.0075907526,
-0.009387856,
0.009126337,
-0.00506609,
-0.020478938,
0.022960015,
0.009106221,
-0.005642772,
-0.0153424395,
0.009568907,
0.012633372,
0.0019027173,
0.03473507,
0.014001317,
-0.008435659,
-0.027278429,
0.027493007,
-0.032642916,
-0.017233422,
0.012888186,
-0.0042379466,
-0.00058506464,
0.027358895,
-0.02926329,
-0.016603094,
0.016240992,
0.0136258025,
0.006353567,
-0.022745434,
-0.0010335024,
0.026339643,
0.0027912108,
0.027104082,
0.011198372,
0.02446207,
0.0096627865,
0.004224535,
0.009139748,
0.003007467,
0.02412679,
0.023483051,
-0.03079217,
-0.008268019,
0.0034668013,
-0.0034802125,
-0.0048649213,
-0.031167682,
0.014524355,
-0.0065513826,
-0.00053770625,
0.023322117,
0.0041708904,
-0.0067760204,
0.03148955,
0.0031214622,
-0.021672538,
0.015181505,
-0.00427818,
-0.0012749044,
0.013531924,
-0.006373684,
-0.0074499343,
0.020680105,
0.042057596,
0.008750823,
-0.03323301,
0.015691131,
0.020036368,
-0.011392834,
-0.015691131,
-0.011607414,
-0.005525424,
0.016080057,
0.015865477,
-0.002035153,
0.0014785874,
0.004248005,
-0.014229308,
-0.0111044925,
-0.01700543,
-0.024730295,
-0.019499918,
-0.006162457,
0.027895344,
-0.004677164,
0.0017124455,
-0.017528469,
0.0021776473,
0.0018205736,
0.0036377944,
0.0028280916,
-0.007094537,
-0.01524856,
-0.0017116073,
0.01557043,
-0.012935124,
0.0010779271,
-0.0011952752,
0.043801054,
0.0140817845,
-0.030094786,
0.01260655,
0.0065346183,
-0.001718313,
0.026138473,
0.010735684,
0.036210302,
0.03331348,
-0.0061591044,
0.0014014728,
-0.0011542034,
-0.015007159,
-0.008650239,
0.020009546,
-0.036156658,
0.019674264,
-0.03237469,
0.013974494,
-0.009347622,
-0.0011122933,
-0.03242834,
-0.026379876,
-0.0060786367,
0.02698338,
0.01124531,
-0.0006353567,
-0.010031595,
-0.0071414765,
0.02367081,
-0.012251153,
-0.0076511027,
-0.0026168649,
0.018440431,
0.0019965959,
-0.001489484,
-0.002529692,
-0.6385888,
-0.030684879,
-0.0011290574,
0.007993089,
0.0022983484,
0.03473507,
0.019808376,
0.0026721861,
-0.005830529,
0.012130451,
0.00909281,
0.012345031,
0.004868274,
-0.010460754,
-0.014712112,
-0.02214193,
-0.01677744,
-0.020022957,
-0.006594969,
-0.020425294,
-0.031382263,
0.0018725421,
0.009159866,
0.013585569,
-0.01080274,
0.00805344,
0.025427679,
-0.0069470135,
-0.003087934,
0.0359689,
-0.03454731,
0.011426362,
0.0035372102,
-0.0057064756,
0.058312,
-0.018239263,
0.0053477255,
0.015543608,
0.022276042,
0.030738523,
-0.0024726943,
-0.00036901818,
0.025870249,
-0.009280566,
-0.020452116,
0.019271927,
-0.005763473,
0.0030946399,
0.009340917,
-0.011929283,
0.004573227,
0.026125062,
-0.032616094,
-0.011647647,
0.0075840466,
0.012244447,
0.009783488,
-0.0071414765,
0.00033402327,
0.0025833368,
0.0051197344,
0.014712112,
0.0033511294,
-0.0020619757,
-0.02116291,
0.016696973,
-0.008013206,
0.020116834,
0.01145989,
-0.01184211,
0.0032924553,
0.013639214,
0.004264769,
0.0022312922,
0.028190391,
0.028109923,
0.008415543,
0.0040133083,
-0.0041843015,
0.0010343406,
0.020975154,
-0.0172066,
-0.030684879,
0.0041910075,
0.029558336,
0.0073426445,
-0.0075907526,
0.02851226,
-0.020680105,
0.023174593,
0.01689814,
-0.0023654045,
-0.0043552946,
-0.022812491,
-0.013531924,
0.00029253232,
0.002633629,
0.009314095,
-0.012941831,
-0.025347212,
-0.020049779,
-0.008475893,
0.022182163,
-0.0016487422,
0.01940604,
-0.004640283,
-0.028753662,
-0.0007828802,
0.013458163,
-0.026031185,
0.015208327,
0.005622655,
-0.004787807,
0.0019932431,
-0.016388515,
-0.025226511,
0.016053233,
-0.0008210183,
0.018292908,
-0.036800396,
0.00029148455,
0.0028683254,
0.00997795,
-0.012485849,
0.017689403,
0.018467255,
0.004418998,
0.005770179,
0.012485849,
-0.031543195,
-0.0047207507,
0.015878888,
0.021565247,
-0.013062531,
0.024730295,
-0.01599959,
0.0075840466,
-0.0017124455,
0.0074834623,
-0.02861955,
-0.01689814,
-0.013840382,
0.004509524,
-0.010977087,
-0.007275589,
-0.014443887,
-0.019768143,
0.00256322,
0.007932738,
0.009615847,
0.004036778,
0.0018121916,
-0.015382673,
0.024542538,
0.008891641,
-0.009776781,
-0.023362352,
-0.007798626,
-0.0074834623,
-0.0040166616,
0.0013327403,
0.010621688,
0.0028180333,
-0.0035070349,
0.0068631936,
-0.0075505185,
0.0027325368,
0.0036042663,
-0.0034768595,
-0.018359965,
-0.0073292335,
-0.0050258557,
-0.02718455,
-0.010380287,
0.000015768665,
0.017072488,
-0.025736138,
-0.0054315454,
-0.017394356,
-0.0029068827,
0.000811379,
0.0012480819,
-0.0045631686,
-0.008060145,
0.046885636,
0.008341781,
0.014980337,
0.011412951,
0.015302205,
0.031596843,
0.00041428106,
0.020385059,
-0.006732434,
-0.0021692654,
0.016522627,
-0.02599095,
0.037444137,
0.0017250186,
-0.010581455,
0.031167682,
0.01754188,
-0.013203349,
0.013907438,
-0.029558336,
0.0074700513,
-0.011922577,
0.0032891026,
-0.027922167,
0.019231694,
0.0018641601,
0.011989634,
0.016093468,
-0.0054784846,
0.014940103,
-0.014564589,
0.015074215,
-0.021779826,
0.0013629155,
-0.02379151,
-0.000678105,
0.0052907276,
0.016817674,
0.014618233,
-0.020224124,
0.007356056,
-0.015382673,
0.017823515,
0.022986837,
0.02400609,
-0.0042714747,
0.0002072453,
0.029397402,
0.0053779003,
-0.00029651375,
0.0064373873,
0.0041910075,
0.020331414,
-0.016066646,
0.0383561,
0.005434898,
-0.012479143,
0.012713839,
-0.0065178545,
0.0077248644,
0.006269747,
-0.006641908,
0.009937717,
0.008925169,
-0.021431135,
0.017327301,
-0.0012271269,
-0.003419862,
0.0024307843,
0.00578359,
0.01962062,
-0.020492349,
0.017327301,
0.023120949,
0.022571089,
0.01645557,
0.0225845,
0.002841503,
0.0062093963,
-0.024837585,
0.016321458,
0.0043552946,
0.004073659,
-0.008958697,
-0.0036813808,
0.003966369,
-0.0200766,
0.010614983,
0.016160524,
-0.057185456,
-0.0016512568,
0.012083512,
0.0031901947,
0.018655011,
0.013612391,
0.018386787,
-0.006675436,
-0.025266744,
0.021310434,
0.018668422,
-0.017045666,
-0.036263946,
-0.02926329,
-0.0035606797,
-0.00294544,
0.004258063,
-0.0023352292,
0.008844702,
-0.017072488,
0.027653942,
-0.009890777,
-0.0025716021,
0.018789124,
-0.0064943847,
0.009736548,
-0.004613461,
0.00056662416,
0.0036813808,
0.008033323,
-0.01853431,
0.020854453,
0.008911758,
-0.0042412993,
-0.009817015,
-0.024703473,
-0.0071079484,
-0.020318003,
-0.027117493,
-0.0013880616,
0.0038255514,
-0.016844496,
0.013672742,
0.0172066,
-0.0016831085,
0.016817674,
0.014940103,
-0.023402585,
-0.0043452363,
-0.0051163817,
0.003366217,
0.0140549615,
0.038999837,
-0.014443887,
0.01557043,
-0.0015406143,
0.013934261,
0.0030326128,
-0.021069031,
0.025937306,
-0.012049984,
-0.014336597,
-0.010407109,
-0.006216102,
0.00644074,
-0.0035070349,
0.008469188,
0.008931874,
-0.01091003,
-0.011962811,
0.012083512,
-0.0033695698,
-0.02629941,
0.01656286,
0.039321706,
0.020291181,
0.001830632,
0.02631282,
0.010145591,
0.018346554,
-0.008127201,
0.005491896,
0.0034500372,
-0.010474165,
0.029585158,
0.014202486,
-0.03781965,
0.034279086,
0.002759359,
-0.0033595115,
0.0067257285,
0.02346964,
0.01610688,
0.011748232,
0.00095219683,
0.011607414,
-0.0015204974,
-0.014417065,
0.007899211,
0.0024726943,
-0.026701745,
0.019043937,
-0.0065312656,
-0.001243891,
-0.011795171,
0.013129587,
0.03355488,
0.005609244,
-0.01842702,
-0.0007154049,
-0.007852271,
0.012257858,
-0.023939034,
0.02357693,
-0.002633629,
-0.0024961638,
0.010373581,
-0.009783488,
-0.025575202,
-0.023429407,
-0.00936774,
0.0128211295,
-0.020331414,
0.00017382203,
0.0017040635,
0.000111690344,
0.015825244,
0.02194076,
-0.02861955,
-0.0018172207,
0.0050392672,
-0.017045666,
-0.00302926,
0.0040200143,
-0.028968243,
-0.012988769,
0.008241197,
0.0059881113,
-0.017380945,
-0.049836107,
0.027707588,
-0.004593344,
-0.0045631686,
0.026044596,
-0.02751983,
-0.020049779,
-0.0009245362,
0.04144068,
0.031301796,
-0.017488236,
-0.0052437885,
0.010333347,
-0.019271927,
-0.022758845,
-0.001926187,
-0.014832813,
-0.018869592,
0.005944525,
0.004197713,
-0.021390902,
0.0019446274,
-0.02125679,
-0.0072957054,
-0.0057433564,
0.0027727704,
0.030765345,
0.015141271,
-0.007966267,
0.008200963,
-0.008958697,
0.009099515,
-0.01709931,
-0.014309775,
0.024757119,
0.0021474722,
-0.022557678,
0.004918566,
-0.003956311,
-0.017233422,
-0.011573886,
-0.011493418,
-0.0070744203,
0.03114086,
-0.019902255,
-0.03398404,
-0.020090012,
-0.0058238236,
0.009736548,
0.00430165,
0.0033511294,
-0.009910894,
-0.008589889,
0.020183891,
0.017528469,
-0.012351736,
0.01008524,
-0.021980995,
-0.025038755,
0.028136747,
-0.01124531,
0.0007497712,
-0.023590341,
0.011915872,
-0.0016202434,
-0.02149819,
-0.008797762,
-0.017045666,
0.013122882,
0.0031315207,
0.047287975,
0.03221376,
0.026487166,
0.0025112515,
0.016026411,
0.028860953,
0.012720545,
-0.012418793,
-0.012036573,
-0.0026470402,
-0.014189074,
0.0046872227,
0.006202691,
0.013686153,
0.006373684,
-0.016361693,
0.028109923,
0.027010204,
-0.019271927,
-0.0055321297,
0.014604822,
-0.041467503,
-0.0425404,
0.00542484,
-0.028646372,
-0.009300684,
-0.047770776,
-0.016938375,
0.012405382,
0.014403653,
0.00660838,
-0.0009203452,
0.015650898,
-0.007858977,
0.032857496,
-0.016281225,
0.010661922,
-0.004248005,
-0.000044765195,
0.00079838687,
0.016401926,
0.023067303,
0.0057902955,
0.009884072,
0.028136747,
-0.03167731,
0.020908097,
-0.0003558165,
-0.024167024,
-0.024408426,
-0.023295294,
-0.009823721,
-0.01249926,
-0.025025342,
-0.021913938,
-0.027399128,
-0.008335075,
0.012733957,
-0.029585158,
0.0018406904,
0.005330961,
-0.008563066,
0.03881208,
0.0016118614,
0.019325573,
-0.023804922,
0.028646372,
0.011775054,
0.01321676,
-0.0050727953,
-0.010232763,
-0.0043452363,
0.014323186,
0.0211495,
0.015650898,
-0.0153156165,
-0.013826971,
0.037846472,
-0.0015230121,
-0.013290523,
-0.02444866,
0.019017115,
-0.027707588,
0.003899313,
-0.00849601,
-0.0062060435,
-0.030872636,
0.0018205736,
-0.013773326,
0.020318003,
-0.0037517897,
-0.01013218,
-0.0225845,
0.016589683,
-0.0067022587,
0.004472643,
0.0013251965,
-0.034171797,
-0.007476757,
-0.015919123,
-0.009991361,
0.011238605,
-0.01578501,
0.00805344,
-0.0030594354,
-0.001668859,
-0.0009681227,
-0.008804468,
-0.0052404352,
-0.023000248,
-0.029746093,
0.04251358,
-0.026956558,
0.0009731519,
0.021229966,
0.0019898904,
-0.007322528,
-0.007530402,
-0.0069134855,
-0.012210919,
-0.02696997,
0.014698701,
0.028244035,
0.010051711,
-0.0070543033,
0.016375104,
-0.024140202,
-0.01566431,
-0.0372832,
-0.022718612,
0.025199689,
-0.065607704,
-0.017675992,
-0.0074700513,
0.0028884422,
0.024260903,
0.016160524,
-0.005495249,
0.010856385,
0.021431135,
-0.013142998,
0.015369262,
0.013947672,
0.0017954275,
-0.025239922,
0.009582319,
0.0006550544,
-0.041494325,
0.012646783,
-0.009280566,
-0.03132862,
-0.019325573,
-0.014524355,
0.010547927,
-0.005693064,
-0.019124404,
0.014282953,
-0.002181,
0.023013659,
0.0040837172,
-0.022182163,
0.022262631,
-0.042915914,
-0.00023511551,
0.0035103876,
0.0027057142,
-0.015878888,
-0.013397812,
-0.019566976,
-0.008288136,
-0.011205077,
0.0014341627,
-0.010474165,
0.014108607,
-0.010990498,
0.009059281,
-0.01260655,
-0.02171277,
-0.029477868,
0.0063569196,
0.005729945,
-0.003952958,
-0.017890573,
-0.0014936749,
-0.017448,
0.018064918,
-0.022450387,
-0.0059646415,
0.01178176,
-0.032160114,
-0.017836927,
-0.008066851,
-0.026607867,
0.029692449,
0.003969722,
-0.0057198866,
-0.021887116,
0.006987247,
-0.01557043,
-0.028297681,
0.023979267,
0.00805344,
-0.0022916428,
0.017568702,
0.0077114534,
0.0031901947,
-0.007081126,
0.01107767,
-0.0077248644,
-0.031301796,
0.012036573,
-0.009086104,
0.019365806,
-0.012492554,
-0.01996931,
-0.010608277,
0.00926045,
0.004318414,
-0.0057668258,
0.032508805,
-0.023630576,
0.0017920746,
0.0144707095,
0.015717953,
0.017193189,
0.028029457,
0.015114449,
-0.023080716,
-0.021390902,
-0.0063300976,
0.012271269,
-0.004144068,
-0.003540563,
0.0043653534,
0.026379876,
0.012552905,
-0.015744776,
-0.01940604,
0.004398881,
-0.032267403,
0.015637487,
0.007865682,
0.023965856,
0.027104082,
-0.012371853,
-0.013746504,
0.0073493505,
-0.010487577,
-0.017032253,
-0.034493666,
0.006014934,
-0.010581455,
0.008683767,
-0.0040334254,
-0.008703884,
-0.032294225,
-0.015583841,
0.00056746235,
-0.0047911596,
-0.014095196,
0.026661512,
-0.025467914,
-0.015074215,
-0.014578,
0.0061825737,
-0.011024025,
0.0036176774,
-0.013679448,
0.0031533139,
-0.003124815,
0.010588161,
-0.020532582,
-0.015597252,
0.01774305,
0.015369262,
-0.0069000744,
-0.0000031596267,
0.011003909,
0.21189733,
-0.011258722,
0.004442468,
0.027814876,
0.0016386838,
0.0041910075,
0.025092399,
0.0038188458,
0.008911758,
-0.00020399728,
0.044149745,
-0.0010930147,
-0.0061892797,
-0.005994817,
0.021806648,
-0.0015758188,
-0.01972791,
-0.01667015,
-0.028673194,
-0.015074215,
-0.0064809737,
-0.02751983,
-0.024716884,
-0.0027241546,
0.015047393,
-0.003470154,
-0.017930806,
0.0027140963,
-0.0023922268,
0.0024576066,
-0.032294225,
0.0027895344,
-0.008931874,
-0.0038557267,
-0.0030275837,
-0.006873252,
-0.027010204,
-0.032508805,
0.003627736,
0.010997203,
-0.010601572,
0.013840382,
-0.026446933,
-0.009314095,
-0.008502715,
0.009173277,
-0.005736651,
0.013987905,
0.015878888,
-0.01799786,
-0.033420768,
0.00006936117,
0.0144707095,
0.002962204,
-0.0047710426,
0.005820471,
0.009991361,
0.009441501,
-0.019164639,
0.03980451,
-0.0073493505,
-0.010306525,
-0.02094833,
0.012740662,
-0.0038087873,
0.016965197,
-0.030953104,
0.008516126,
0.015288794,
-0.030979926,
0.0051867906,
-0.015731364,
-0.007892505,
0.0046604,
0.01343134,
-0.038409743,
0.033715814,
0.02686268,
0.029692449,
0.029907027,
0.0057098283,
-0.0012858011,
-0.024421837,
0.0098706605,
-0.0010435608,
-0.023751276,
0.0075840466,
0.006283158,
-0.02674198,
-0.014296364,
0.014698701,
-0.010199235,
0.0007070229,
0.008683767,
0.0041876542,
0.0031734307,
-0.0034064506,
0.00970302,
0.00021353182,
-0.03800741,
-0.020492349,
0.069684714,
0.035942078,
0.009971244,
-0.023161182,
0.0062395716,
-0.013055826,
0.00027451097,
0.040501893,
-0.018480666,
0.025695903,
-0.02993385,
0.015047393,
-0.010963675,
-0.008288136,
0.017367534,
0.00071414764,
-0.023496464,
0.020344825,
-0.008040029,
-0.0022614675,
-0.012707134,
-0.0048179817,
0.029746093,
-0.030470299,
-0.011265428,
-0.014403653,
-0.021967584,
0.004573227,
-0.0009396238,
-0.019808376,
-0.008516126,
0.017582113,
-0.0045162295,
0.005853999,
-0.01754188,
0.0024123439,
0.011620825,
-0.0252131,
0.025669081,
-0.013270405,
0.0076511027,
0.008455777,
0.0016805939,
-0.010628395,
-0.018547721,
0.019352395,
0.014873046,
-0.023831744,
-0.018869592,
-0.02050576,
-0.032321047,
-0.020116834,
-0.007335939,
0.03060441,
0.0025950717,
-0.0065513826,
-0.014765757,
-0.0130021805,
0.008918463,
-0.028995065,
0.016924964,
0.014095196,
-0.01188905,
-0.02006319,
0.0025665727,
-0.17005432,
-0.0007434847,
0.039107125,
-0.025897073,
0.022101697,
0.0066050272,
0.004056895,
-0.0140549615,
-0.037229557,
0.010796035,
0.027761232,
0.026406698,
-0.02313436,
-0.0128211295,
0.00027136772,
0.022732023,
0.009200099,
0.051284518,
0.033608526,
0.0009396238,
0.020961741,
-0.027466185,
0.009575614,
-0.01700543,
-0.014537766,
-0.0034131564,
0.009314095,
0.017354123,
-0.007356056,
-0.029102355,
-0.02412679,
-0.004569874,
0.011506829,
-0.01025288,
0.020961741,
0.005009092,
-0.020344825,
0.0042547104,
0.0026705097,
0.017568702,
0.02148478,
0.013934261,
0.013250289,
0.00008434402,
0.001468529,
0.050479844,
0.015449729,
-0.00023825876,
0.023496464,
-0.0144975325,
0.00970302,
-0.020090012,
0.00041470016,
0.012485849,
0.026165297,
0.016643329,
0.02061305,
0.016321458,
-0.010118768,
-0.012546199,
-0.004442468,
-0.014403653,
0.024971697,
0.00066637015,
-0.022061462,
-0.031838246,
-0.007134771,
0.017166365,
-0.0113391895,
0.00023029585,
-0.033742636,
0.0052739633,
0.022369921,
-0.006108812,
0.019245105,
-0.00887823,
0.019647442,
0.015288794,
-0.011667764,
0.012512671,
-0.0075840466,
0.027318662,
-0.023067303,
-0.003932841,
0.0005787781,
0.028324503,
0.0093208,
0.020586228,
0.00084155425,
-0.0072822943,
-0.0035372102,
-0.029907027,
0.009602436,
-0.01124531,
0.011587297,
0.021095853,
-0.016415337,
-0.01656286,
0.0015825244,
0.0022128518,
0.009287272,
-0.020492349,
-0.024810763,
0.011359306,
0.055522464,
-0.0001042513,
-0.007543813,
0.0062965695,
0.04012638,
-0.008864818,
-0.015945945,
-0.016522627,
0.0092470385,
0.0059612887,
-0.002450901,
0.046000496,
0.00548519,
-0.002787858,
0.0051432042,
-0.028646372,
0.060243215,
-0.009374445,
-0.009206804,
0.014189074,
0.010333347,
-0.030684879,
-0.12821129,
-0.00091363955,
-0.0015917446,
-0.0048984494,
0.0031281677,
0.01578501,
0.005971347,
0.017327301,
-0.018252674,
0.02511922,
-0.029853383,
0.009119632,
0.008107085,
-0.01656286,
0.0140683735,
-0.008703884,
0.023094127,
0.0006219455,
-0.028324503,
0.033420768,
-0.003191871,
0.0038188458,
-0.008422248,
-0.006162457,
0.01709931,
0.010695451,
-0.038409743,
0.014376831,
0.011681176,
0.017903984,
-0.00899893,
-0.0094280895,
0.013826971,
-0.0046604,
-0.012619961,
0.0023704336,
-0.020478938,
-0.024435248,
0.020921508,
-0.021994406,
0.0024492247,
0.021846883,
0.010655217,
0.006665378,
0.0252131,
-0.012063395,
-0.0072353547,
0.017421179,
0.0073761726,
-0.007952855,
-0.040609185,
-0.0153424395,
-0.023737865,
-0.013552041,
0.010118768,
-0.038195163,
0.017515058,
0.014604822,
-0.025159454,
-0.02160548,
-0.0134179285,
-0.0005766826,
0.0018809241,
0.005216966,
0.01818562,
-0.036263946,
-0.012593139,
-0.0068095485,
0.01052781,
-0.0028549142,
-0.013511808,
0.009307389,
-0.011473302,
-0.00036797044,
-0.009682903,
0.0057400037,
-0.019835198,
-0.008100379,
-0.0104942825,
-0.01667015,
-0.022866135,
-0.012210919,
0.006108812,
-0.006960425,
0.029182822,
0.00056159496,
0.0035942078,
-0.009521969,
0.011728114,
0.0012757427,
-0.0064139175,
0.057936486,
-0.011278839,
-0.039214417,
-0.021900527,
0.023858566,
-0.0010192529,
0.01480599,
0.031382263,
0.018775713,
-0.013075942,
-0.009314095,
-0.060672373,
0.025159454,
0.00855636,
0.009019048,
0.01908417,
-0.006236219,
-0.00045681978,
0.00085664185,
-0.013478279,
0.037766006,
0.016911553,
0.010903324,
-0.049728815,
-0.01036017,
-0.025628848,
-0.00038138166,
0.010018184,
-0.0025766313,
0.013075942,
0.020881275,
0.00066301733,
0.0107155675,
0.010943558,
0.00032794633,
-0.013277111,
-0.012123746,
-0.032079645,
0.033957217,
-0.0056494777,
-0.011667764,
0.01578501,
-0.03401086,
-0.018708656,
-0.012680312,
-0.014108607,
-0.013947672,
0.0068799574,
0.03004114,
0.0088178795,
0.03795376,
-0.006578205,
-0.037846472,
0.002251409,
-0.00082227564,
-0.008844702,
0.0038020818,
-0.02204805,
0.008656944,
-0.019459685,
-0.0031482847,
0.040045913,
0.013686153,
0.0046235193,
-0.045624983,
-0.015007159,
-0.008469188,
-0.02827086,
-0.008187552,
-0.019473096,
-0.030067962,
0.015275383,
0.020693518,
0.0077583925,
0.009991361,
-0.008100379,
-0.0126132555,
-0.020291181,
-0.0025766313,
0.0062965695,
-0.027707588,
-0.037363667,
0.0020653284,
0.023201415,
-0.01688473,
0.0069134855,
-0.02422067,
-0.013659331,
-0.0013344167,
-0.012096924,
0.010246174,
0.01101732,
-0.015771598,
-0.0013629155,
-0.0056897113,
0.02707726,
-0.0025196336,
0.012680312,
0.016790852,
0.004248005,
0.015530196,
-0.0076980423,
0.009407973,
0.03604937,
0.0252131,
-0.0005196849,
0.01107767,
-0.0077919206,
0.0055723633,
0.020961741,
0.04267451,
-0.012345031,
-0.013826971,
0.018038096,
-0.0004672973,
-0.012438909,
0.017890573,
-0.014202486,
-0.01754188,
-0.003237134,
0.0009672845,
0.013552041,
0.0053074914,
-0.0092202155,
0.0059177023,
-0.021980995,
0.0008545464,
-0.0009999743,
0.0031985766,
-0.012257858,
0.047797598,
0.022007817,
-0.0076980423,
0.015449729,
0.007684631,
0.010433932,
0.0037752592,
0.025266744,
-0.0115604745,
0.036693107,
-0.017608937,
0.021873705,
-0.0032572509,
-0.005656183,
-0.015489963,
-0.015422907,
-0.00893858,
0.026809035,
0.04267451,
0.016147112,
0.09591707,
0.021511601,
-0.04012638,
0.006128929,
-0.02259791,
0.01755529,
0.031194504,
0.005005739,
-0.04055554,
-0.027868522,
0.0117683485,
-0.043345075,
0.00893858,
-0.029907027,
-0.018453844,
0.026178708,
0.011057554,
0.004955447,
0.026715156,
-0.011064259,
0.003731673,
-0.0061825737,
-0.009119632,
0.026245764,
-0.03454731,
-0.020841042,
0.014631645,
-0.008992225,
0.0032253992,
-0.03379628,
0.017220011,
-0.022544267,
-0.022262631,
0.0008809497,
0.017300477,
-0.015878888,
-0.004559816,
-0.01436342,
0.011714703,
0.026822446,
-0.0020083308,
-0.01689814,
-0.0115604745,
-0.0054617207,
0.009052576,
-0.0064005065,
-0.01709931,
-0.019902255,
0.00970302
] |
Cellular circular RNAs (circRNAs) are generated by head-to-tail splicing and are present in all multicellular organisms studied so far. Recently, circRNAs have emerged as a large class of RNA which can function as post-transcriptional regulators. It has also been shown that many circRNAs are tissue- and stage-specifically expressed. Moreover, the unusual stability and expression specificity make circRNAs important candidates for clinical biomarker research. Here, we present a circRNA expression resource of 20 human tissues highly relevant to disease-related research: vascular smooth muscle cells (VSMCs), human umbilical vein | [
-0.040005766,
-0.009988212,
0.014102562,
-0.0020439455,
0.0068991426,
-0.005791179,
-0.024818392,
0.009287053,
-0.016523546,
0.0021663175,
0.00067842123,
-0.012878841,
-0.01826983,
-0.0027732172,
-0.0017562056,
0.024725787,
0.009915451,
0.005959854,
0.004230107,
0.003055996,
-0.03241208,
0.021087697,
-0.022026984,
-0.008083176,
0.00075903797,
0.016933657,
0.016285416,
-0.035428386,
0.0035157185,
-0.049028233,
0.010292489,
-0.013546927,
-0.034026068,
-0.029237019,
0.0038497613,
0.0016908853,
0.005347993,
-0.022754602,
0.005037102,
0.006287282,
0.037465718,
0.008625582,
-0.006131836,
-0.0025764296,
-0.005235543,
-0.0034065756,
0.01197924,
-0.016020829,
0.0095781,
0.02144489,
0.027173229,
-0.008989391,
-0.025440175,
-0.009888992,
-0.018521188,
0.01595468,
-0.011106098,
0.029131183,
-0.020439455,
-0.008929859,
0.0027351826,
-0.00057506637,
-0.023005962,
-0.0033271993,
0.013798285,
0.011840331,
-0.000746222,
0.022992732,
0.0036810862,
0.0004175536,
0.021802085,
0.002103478,
0.0044186264,
0.018534418,
0.013811515,
-0.032729585,
-0.014949245,
-0.0009293668,
0.0024127155,
-0.0053513004,
0.0038993717,
-0.00025280594,
0.021087697,
0.030956844,
0.012257058,
-0.0066180173,
-0.011846946,
0.021061238,
0.0035984023,
-0.013560156,
0.046488184,
0.04471544,
0.012038773,
0.017449606,
-0.024315674,
-0.005820945,
-0.00832792,
0.0287343,
-0.008843867,
-0.036195695,
-0.008572664,
0.023561597,
-0.011006878,
-0.003734004,
-0.0125679495,
-0.01084151,
0.011860175,
-0.005093327,
0.020386538,
0.0019480322,
-0.021259679,
0.013116971,
-0.002928663,
-0.032226868,
0.025837058,
0.008030258,
0.043657087,
-0.0052024694,
-0.007157116,
-0.014208398,
0.033417515,
0.0023217632,
0.011079639,
-0.035719436,
0.016999805,
0.0064658793,
0.00053496467,
0.012812694,
-0.0005944971,
-0.0013708987,
-0.00086073915,
-0.012462114,
-0.0007954189,
0.035243176,
-0.007739211,
-0.01106641,
0.004498003,
-0.00797734,
-0.011939552,
-0.02897243,
-0.020505602,
0.03241208,
-0.027279064,
0.00025280594,
0.014539133,
0.007031437,
0.029263478,
0.017145328,
0.0184815,
0.0065518706,
0.0100345155,
-0.011767569,
0.01643094,
-0.016774906,
-0.001974491,
0.018402124,
-0.0008065812,
0.032729585,
0.004220185,
-0.013408017,
-0.005662192,
0.0018587336,
0.027279064,
0.009174603,
0.0074812374,
0.017978782,
-0.02009549,
-0.0005258695,
-0.0022026985,
-0.0026095032,
-0.011846946,
0.014790492,
-0.036195695,
0.011615431,
-0.019923506,
0.013216191,
0.0006722199,
0.014353921,
-0.027040936,
-0.031803526,
0.008652041,
-0.011906479,
0.018560877,
-0.011747725,
-0.018415352,
-0.00969055,
0.016761675,
-0.005662192,
0.0046898294,
-0.027517194,
-0.02032039,
0.010874583,
0.021590414,
-0.008255159,
-0.6312021,
-0.054558128,
0.004240029,
-0.021180302,
0.023574827,
0.019023906,
0.011463293,
-0.015227063,
-0.014102562,
0.022635538,
-0.008136094,
0.0065617925,
0.0154651925,
-0.0020290622,
-0.035507765,
-0.044133347,
0.0052851536,
-0.011112713,
0.026061958,
-0.006062382,
-0.033020634,
0.00808979,
0.023098568,
0.011820487,
0.0076598343,
0.01060338,
0.022198968,
-0.015928222,
-0.01072906,
0.02145812,
-0.022331262,
0.02809929,
-0.027755324,
-0.011423605,
0.046276513,
-0.010411554,
-0.03405253,
0.011159016,
-0.005113171,
0.023111798,
-0.0037836141,
0.009042309,
0.029792655,
0.015412275,
-0.020029342,
0.010180039,
0.0037869215,
-0.015081539,
0.009525183,
0.006062382,
-0.022794291,
0.01438038,
-0.017621588,
0.00051098637,
0.0058011007,
0.009167988,
0.03217395,
-0.028945971,
0.01129131,
0.0014742535,
-0.00015368866,
0.022728145,
-0.027305523,
-0.031856444,
0.009968368,
0.013546927,
-0.016364792,
-0.006885913,
0.02077019,
0.012687014,
0.009723624,
0.037571553,
0.002164664,
-0.014009956,
-0.010967189,
0.038497612,
0.012395967,
0.007719367,
0.0029270092,
0.022119591,
0.014671427,
-0.003528948,
-0.016589694,
0.014036415,
0.008017029,
0.010755518,
-0.023005962,
0.028258042,
0.004117657,
0.012303361,
-0.009882377,
-0.010649683,
-0.0028443253,
-0.03265021,
-0.03265021,
0.02854909,
0.0065088747,
0.019354641,
0.016841052,
-0.013282338,
-0.016682299,
0.010127122,
-0.010524004,
-0.0132029615,
0.004603838,
0.0006585771,
-0.020717273,
0.011919708,
0.025082981,
-0.051647656,
0.015425504,
-0.0036248611,
0.004266488,
0.0058507114,
-0.016721988,
-0.017462835,
0.019751525,
0.019063596,
-0.008096405,
-0.033496894,
-0.0014998856,
-0.017700965,
0.0102461865,
-0.013315411,
0.025321111,
0.002908819,
-0.006330278,
-0.025995811,
0.001558591,
-0.011708037,
-0.004891578,
-0.009048924,
0.02443474,
-0.019486936,
0.013573385,
-0.0042532585,
0.012343049,
0.014102562,
-0.00091613736,
-0.033073552,
-0.012389353,
-0.01322942,
0.0011145787,
-0.0057415683,
-0.0029121262,
-0.021696249,
-0.028522631,
0.012720088,
0.00049775693,
0.011648505,
0.003614939,
-0.01186679,
0.01016681,
0.0076135313,
0.007395246,
-0.0063567366,
-0.039476592,
-0.028522631,
-0.0064328057,
-0.017886177,
-0.0006581637,
0.028469713,
-0.021180302,
0.015901763,
-0.011132557,
0.00009400123,
-0.02029393,
-0.0034528787,
-0.00405151,
-0.033179387,
0.0054339846,
0.004266488,
0.005354608,
0.00879095,
0.007229878,
0.012673785,
-0.017687734,
0.014816951,
-0.0106364535,
-0.012918529,
-0.0022126206,
-0.028284501,
-0.020717273,
-0.01221737,
0.01117886,
0.013335256,
0.027305523,
-0.00008159865,
0.033179387,
0.01711887,
-0.0054141404,
0.015240292,
-0.028363878,
0.02030716,
0.014737574,
-0.030189537,
-0.0030593034,
0.010431398,
0.010775363,
0.006032616,
0.019328183,
-0.022661997,
-0.0018339284,
-0.02124645,
-0.009267209,
-0.018388893,
0.0075209253,
0.009664091,
0.017608358,
0.0037273893,
0.021788856,
0.017065952,
-0.006780078,
-0.00045476132,
0.0060425377,
0.010484315,
-0.0010434706,
-0.022026984,
0.0036380906,
-0.006035923,
-0.0013816475,
0.005063561,
0.0019116512,
-0.004574072,
-0.00924075,
0.012078461,
-0.015928222,
0.014803722,
-0.011714652,
-0.001625565,
0.000979804,
0.014274545,
0.011125943,
0.013864432,
0.007831817,
0.008169167,
0.008876941,
-0.022754602,
0.03770385,
0.01460528,
-0.008275002,
0.00622775,
-0.009545026,
-0.021802085,
0.003565329,
-0.0016594654,
0.025440175,
0.0069256015,
0.00427641,
0.008308076,
-0.02194761,
0.0012162798,
-0.033073552,
-0.008248543,
0.013361715,
-0.008056717,
0.011959396,
0.007401861,
0.042307686,
0.01710564,
0.011211934,
0.0037306966,
-0.004154038,
-0.018388893,
-0.011264851,
0.011622046,
0.017185017,
-0.010199883,
-0.034105446,
0.015795927,
-0.015187374,
-0.0074812374,
0.017555442,
-0.031221433,
0.020730501,
0.005744876,
0.013718909,
0.022225427,
0.002374681,
0.0019364564,
-0.0200558,
-0.029316396,
0.015597487,
-0.0034429566,
-0.011251622,
-0.034158364,
-0.01084151,
0.0037902289,
-0.004312791,
0.010008057,
-0.0053116125,
0.007236493,
-0.0010939077,
0.01599437,
-0.0023151485,
0.019791214,
0.023217633,
-0.02533434,
0.029051807,
-0.0032957795,
-0.0054835947,
-0.0007185229,
0.010193269,
-0.011218549,
0.035560682,
0.003189944,
-0.0053182268,
0.024223069,
-0.008599123,
-0.009048924,
-0.024950687,
-0.03243854,
0.0021133998,
-0.012349664,
0.009068768,
0.009597944,
0.026379464,
-0.01759513,
0.022437098,
0.009485494,
-0.019738296,
-0.022172509,
-0.007970726,
0.0076995227,
0.0184815,
0.018865153,
-0.012885455,
0.015491651,
-0.002445789,
-0.019830901,
-0.028284501,
-0.014181939,
0.014816951,
-0.021100925,
-0.004041588,
-0.016020829,
-0.0028807062,
-0.016364792,
0.0014081064,
0.023588056,
-0.015372586,
-0.014234857,
-0.009373045,
0.0129053,
0.033179387,
0.0070182076,
0.012362894,
0.04632943,
0.0278347,
0.0036380906,
0.0053513004,
0.016907198,
0.02145812,
-0.023945251,
0.012303361,
0.020280702,
-0.0028079445,
0.015227063,
-0.005860633,
-0.009743468,
0.020267472,
0.0074613933,
0.0029716585,
-0.007011593,
0.0200558,
0.029713279,
0.021193532,
0.0033966536,
0.011264851,
-0.011794028,
-0.008129478,
0.0043425574,
-0.008982777,
-0.006885913,
0.022026984,
-0.009617789,
0.009220906,
-0.030163078,
0.01598114,
-0.0060590743,
0.0038596834,
0.014089333,
-0.0034032683,
-0.022833979,
0.015663633,
0.0032031734,
-0.0022291574,
-0.0065584853,
0.0035091038,
-0.0067304675,
-0.0015048466,
-0.0012063577,
-0.016721988,
-0.006184754,
-0.00061971566,
-0.026181024,
-0.018230142,
0.005040409,
0.021180302,
0.019751525,
0.023707122,
-0.004220185,
0.007421705,
0.0273849,
0.004944496,
-0.031168515,
0.0033867317,
-0.032544374,
-0.012475343,
-0.0011716306,
-0.008910014,
-0.016232498,
-0.027993454,
-0.025413716,
0.0033718485,
0.008347765,
0.02510944,
-0.015637174,
0.013434476,
0.015544569,
0.03198874,
0.010689371,
0.0002579737,
-0.01175434,
-0.010180039,
-0.037095293,
-0.020016113,
-0.022013756,
-0.0054240623,
-0.030956844,
-0.01084151,
0.02735844,
-0.01665584,
-0.00059573737,
0.007884734,
-0.008698344,
-0.0010029555,
0.021418432,
0.0052586948,
0.009445806,
-0.0017099025,
0.018388893,
-0.0010674489,
-0.025559241,
-0.028496172,
0.014062874,
0.016351564,
0.000057723682,
-0.022900127,
0.03405253,
0.0016131625,
-0.014988934,
-0.03421128,
0.0028079445,
-0.018931301,
0.04455669,
0.0067304675,
-0.03537547,
0.0018041622,
-0.024342133,
0.018904842,
0.010510774,
-0.009452421,
-0.0016908853,
-0.017714193,
0.017542211,
-0.0070446664,
-0.003482645,
-0.004481466,
-0.027490735,
0.01095396,
0.029184101,
0.026392695,
-0.0008111288,
0.0045906086,
0.007646605,
-0.009280439,
-0.008069946,
0.01850796,
-0.03360273,
-0.0065816366,
0.0024623259,
0.035031505,
0.020399766,
0.03265021,
-0.0034396492,
-0.012865611,
0.040270355,
0.0111193275,
0.0035818655,
-0.021828543,
0.0021200145,
-0.0064195762,
0.011780798,
0.038259484,
0.005056946,
-0.013156659,
-0.02762303,
-0.023244092,
0.006429498,
-0.015822386,
-0.024818392,
0.014089333,
-0.00969055,
-0.041434545,
-0.018997448,
-0.014248086,
0.0023366464,
-0.035481304,
-0.013540312,
0.014909557,
-0.009306897,
0.02854909,
-0.032544374,
0.022212196,
-0.0014469678,
0.018071389,
-0.015319669,
0.04220185,
-0.017833259,
-0.017899405,
-0.014208398,
0.003724082,
0.033020634,
0.0064228834,
0.01369245,
0.014234857,
-0.00914153,
0.0107885925,
0.0061516804,
-0.04630297,
0.0022490015,
0.011231778,
-0.0120850755,
-0.0030725328,
-0.01255472,
-0.018627023,
-0.03635445,
-0.005830867,
0.020823108,
-0.011860175,
0.023085339,
-0.015809158,
-0.022410639,
0.04524462,
0.0003241208,
0.018560877,
-0.0041242717,
0.0046898294,
0.008420526,
-0.019447248,
-0.026551446,
-0.019288495,
0.014234857,
-0.028337419,
0.04315437,
0.01483018,
-0.004160653,
-0.0031056064,
0.016616153,
0.020241013,
-0.004722903,
-0.030083701,
0.002445789,
-0.009075383,
-0.0055166683,
-0.005768027,
-0.008943088,
0.0010095701,
0.022410639,
-0.019314954,
0.0044583147,
-0.016378023,
0.010563692,
-0.016086975,
0.030745173,
-0.0144994445,
0.018772548,
-0.0005221487,
-0.025506323,
-0.027027706,
-0.022053443,
-0.0009789771,
-0.0020869412,
0.017661275,
0.004918037,
-0.0070711253,
-0.0013320373,
0.027279064,
-0.0065981736,
0.0042962544,
-0.015888534,
-0.00491473,
0.04267811,
-0.03444941,
-0.012878841,
0.029713279,
0.02968682,
0.00079211156,
-0.010795207,
0.002938585,
-0.0052686166,
-0.0116022015,
-0.002958429,
0.025823828,
0.014856639,
-0.0011360765,
-0.011350843,
-0.012468728,
-0.00552659,
-0.046752773,
-0.011278081,
0.0028410181,
-0.04561504,
-0.03534901,
0.013408017,
0.040508486,
0.041857887,
0.005811023,
0.005225621,
-0.014512674,
0.038497612,
-0.006498953,
0.014459756,
-0.014129021,
-0.024474427,
-0.016510317,
0.019685378,
0.0062938966,
-0.039847013,
0.019195888,
-0.032676667,
-0.010867969,
0.0053149196,
-0.008069946,
0.027808242,
0.005506746,
-0.01460528,
0.010285874,
0.02168302,
-0.002467287,
0.011350843,
-0.012594408,
0.020214554,
-0.021735938,
-0.014115792,
-0.00518924,
0.0012179335,
-0.0014386994,
-0.0039059864,
-0.014393609,
0.01436715,
-0.013851203,
-0.015319669,
-0.016576463,
0.0066345544,
-0.01438038,
-0.0041738823,
0.0034859523,
0.013176503,
-0.016602922,
0.015610716,
0.002652499,
-0.0071108136,
-0.03553422,
0.008480058,
0.027675947,
0.016007598,
0.013732138,
0.020267472,
-0.013639532,
-0.032464996,
-0.027966995,
0.0034793376,
-0.009809615,
0.025162358,
0.0193811,
-0.009346586,
-0.0022473477,
0.00844037,
-0.05135661,
-0.03011016,
0.032517914,
0.03558714,
0.001051739,
0.015663633,
0.025519552,
-0.022119591,
-0.01072906,
-0.0032230176,
0.013705679,
-0.025254963,
0.016550004,
0.009882377,
0.0067470046,
0.011079639,
-0.052864764,
-0.02123322,
0.024911,
0.010570307,
-0.014539133,
0.0141687095,
-0.015359357,
0.020823108,
-0.026300088,
0.0045773797,
-0.008857097,
0.014671427,
0.029342854,
-0.034396492,
-0.02009549,
0.014353921,
-0.01620604,
0.0024044472,
0.012773005,
-0.017661275,
0.020016113,
0.010477701,
0.008202241,
-0.02143166,
0.032756045,
-0.010067589,
0.005897014,
0.0191562,
0.0061219144,
0.033867314,
0.018177224,
-0.01733054,
-0.021656562,
-0.026577905,
0.00043657087,
-0.010781977,
0.036777787,
0.013943809,
-0.0030543425,
0.013030979,
0.003882835,
-0.019698607,
-0.010828281,
-0.0036281685,
-0.017608358,
-0.011258237,
-0.009571485,
-0.02210636,
-0.014975704,
0.0045608426,
0.009154759,
-0.015332898,
-0.015835617,
0.017013034,
-0.005619196,
-0.0045376914,
0.03032183,
0.013546927,
-0.015213833,
-0.0005634906,
0.0049775694,
-0.0029749658,
-0.0191562,
0.009339971,
0.1882811,
-0.00023048131,
0.0043425574,
0.0034528787,
0.0010566999,
-0.022291573,
0.0018736167,
-0.0093532,
-0.018322747,
0.011661734,
0.013017749,
-0.0045409985,
-0.008652041,
0.00069495797,
0.0062542083,
-0.025995811,
-0.025360798,
-0.0012038773,
-0.008208855,
-0.018190453,
-0.015346128,
-0.020624666,
-0.0171321,
-0.013057438,
0.015676863,
-0.011615431,
-0.02759657,
0.0057051876,
0.0013188078,
0.010352021,
-0.02968682,
-0.015319669,
0.002348222,
0.018759318,
0.022278344,
0.010735675,
-0.009009236,
0.01015358,
0.0019546468,
-0.023786498,
-0.009631018,
-0.0007681332,
0.00009710188,
-0.005698573,
0.018402124,
0.009472265,
-0.015107998,
-0.0017611666,
-0.0018851924,
-0.013030979,
-0.051303692,
0.046170678,
0.010947346,
0.035984024,
0.015848845,
0.004378938,
0.0019678762,
0.030533502,
0.009121685,
0.03286188,
-0.01162866,
0.008301461,
-0.008420526,
-0.004471544,
-0.021537496,
0.028469713,
-0.01804493,
-0.013970268,
0.021722708,
-0.023707122,
0.007818587,
-0.013328641,
-0.024474427,
-0.00022882763,
-0.014962475,
-0.007785514,
0.034317117,
0.016814593,
-0.0021133998,
0.024183381,
0.0082220845,
-0.01106641,
-0.042334147,
0.0017495909,
0.019513395,
-0.046541102,
0.011397146,
0.011721266,
-0.01119209,
-0.014936016,
0.017357,
-0.018137535,
-0.0019711836,
-0.00088141015,
0.012045387,
0.005830867,
-0.026604364,
-0.01776711,
-0.0030973381,
-0.025744451,
-0.034555245,
0.086202905,
0.0062905895,
0.0077987434,
0.0073423283,
0.012647326,
-0.026842494,
0.0034760302,
0.005698573,
-0.03148602,
0.002923702,
-0.03011016,
0.017727423,
-0.0027814857,
0.0077061374,
0.016814593,
0.041910805,
-0.035005048,
0.033920232,
0.0068594543,
-0.0018289674,
-0.0068263807,
-0.0048485827,
0.024818392,
0.0027732172,
0.013533697,
-0.009498724,
0.0009425962,
-0.011086254,
-0.02237095,
0.0055861226,
-0.016351564,
-0.00070198614,
0.01619281,
0.023561597,
-0.025162358,
0.0105173895,
-0.00076441246,
0.010464472,
0.0107885925,
-0.010947346,
-0.00039398868,
0.0046600634,
-0.0100940475,
-0.004064739,
0.004498003,
0.023654204,
0.008446985,
-0.019341413,
-0.023852644,
-0.024487657,
-0.016325105,
0.0046799076,
-0.004719596,
0.023151485,
-0.016113434,
-0.016100205,
-0.026088417,
-0.002569815,
-0.0031304115,
-0.036433823,
-0.011774184,
0.01942079,
-0.015319669,
0.0009781503,
-0.005576201,
-0.16542067,
0.013295568,
0.013626303,
-0.042519357,
0.01894453,
-0.003697623,
0.00025073887,
0.019209119,
-0.0046137604,
0.013388174,
0.02510944,
0.0057514906,
-0.03198874,
-0.035560682,
0.018296288,
0.0020522138,
0.011833716,
0.026577905,
0.018759318,
0.0072232634,
0.0314331,
-0.016602922,
-0.002506975,
-0.027808242,
-0.007203419,
-0.0037009304,
0.0012179335,
-0.019592771,
-0.010682757,
-0.012052002,
-0.00552659,
0.011588972,
0.005308305,
-0.0023631053,
0.015795927,
0.005933395,
-0.017357,
-0.028469713,
-0.0084337555,
0.010080818,
0.020188095,
0.02124645,
-0.014949245,
-0.005979698,
-0.002204352,
0.022701686,
-0.0063203555,
-0.025823828,
0.0064427275,
-0.018349206,
0.009029079,
-0.006323663,
0.022503244,
0.008830638,
0.015372586,
0.013030979,
0.012534875,
0.044900652,
0.014909557,
-0.015690092,
-0.004461622,
-0.021365514,
0.01850796,
0.009968368,
0.0039258306,
-0.011430219,
0.017185017,
0.017899405,
-0.0043524792,
0.013970268,
-0.031353727,
-0.011721266,
0.00048039333,
-0.020069031,
0.019129742,
0.02465964,
-0.023230862,
0.027437817,
-0.00065568316,
-0.0003028297,
-0.0038993717,
0.015015393,
-0.012045387,
-0.017952323,
-0.0044450853,
-0.014790492,
0.012091691,
0.012845767,
-0.00787812,
-0.0116022015,
0.037598014,
-0.0018041622,
-0.0025780832,
-0.0019645689,
-0.014314232,
0.022053443,
-0.0035256406,
-0.022185737,
-0.0005271097,
-0.015266751,
0.023640973,
-0.0059730834,
-0.0072894106,
0.018018471,
0.025797369,
0.01129131,
-0.010047745,
-0.010352021,
0.05519314,
-0.008572664,
0.002753373,
-0.002272153,
0.015346128,
0.013408017,
0.0014262969,
0.020651124,
-0.029369313,
-0.021365514,
-0.0016594654,
-0.024924228,
0.065776676,
0.014777263,
0.0041474234,
0.009809615,
0.011608817,
-0.027781783,
-0.13388173,
-0.015028622,
-0.00285094,
0.03241208,
-0.032121032,
0.015425504,
-0.0073886313,
0.047625914,
-0.015028622,
0.031168515,
-0.015571028,
-0.018838694,
-0.0057514906,
-0.0020406381,
0.0059102434,
-0.013123585,
-0.01914297,
-0.013408017,
0.00091365684,
0.020360079,
-0.0034528787,
0.0002796782,
-0.014724345,
-0.021140615,
0.017383458,
0.0068263807,
-0.016470628,
0.0066114026,
0.027120313,
0.004021744,
-0.024381822,
-0.0006077265,
0.005040409,
0.0076796785,
-0.001532959,
0.0051561664,
-0.0032246711,
-0.02079665,
0.019195888,
-0.0059300875,
0.0032775889,
0.01733054,
0.008003799,
-0.0013609766,
0.009545026,
-0.00014097602,
-0.012223984,
0.00017559988,
-0.01641771,
-0.019672148,
-0.03148602,
-0.031829987,
-0.0110597955,
-0.028363878,
0.020439455,
-0.027966995,
0.017872946,
0.022093132,
-0.0013312104,
-0.02897243,
0.006088841,
-0.0025995811,
-0.02809929,
0.013560156,
0.026207482,
-0.012594408,
-0.012045387,
-0.03627507,
0.01438038,
-0.040429108,
-0.0075341547,
0.00325113,
-0.0044219336,
-0.00730264,
-0.01711887,
0.0069256015,
-0.009055538,
-0.01709241,
-0.0054141404,
-0.0065419483,
-0.00028898014,
-0.02372035,
0.024077546,
-0.019592771,
0.007124043,
-0.0004349172,
0.012773005,
-0.008241929,
0.0013055784,
-0.023654204,
0.011092869,
0.031009762,
-0.018799007,
-0.014208398,
-0.0040581245,
-0.005205777,
-0.0028443253,
-0.006591559,
0.0059466246,
0.0049974136,
-0.0063137407,
0.0026458842,
-0.054611046,
0.0054637506,
0.0039258306,
-0.001862041,
-0.0014312579,
-0.035666518,
0.01916943,
-0.009796386,
-0.011020107,
0.014539133,
-0.04151392,
0.006429498,
0.0024904383,
0.009650862,
-0.042783946,
0.0061913687,
0.039767638,
0.011205319,
0.022635538,
0.02807283,
-0.010815051,
0.022913355,
0.0007693735,
0.0044517,
0.00022882763,
-0.0013940502,
-0.009088612,
0.008744647,
-0.017304081,
-0.020174867,
0.006819766,
-0.018600564,
-0.01895776,
0.011086254,
-0.011747725,
-0.018455042,
0.0019513395,
0.039476592,
0.014988934,
0.02554601,
-0.015650405,
-0.05709818,
0.015160915,
0.048948854,
-0.013368329,
0.017264394,
-0.021087697,
-0.0075672283,
0.017396688,
-0.012647326,
0.026233941,
0.019804442,
-0.007686293,
-0.0262604,
-0.005625811,
0.0049246517,
0.005169396,
-0.012488573,
-0.0032627059,
-0.013269109,
0.033020634,
0.03196228,
0.008334535,
0.0047460548,
0.0007305121,
0.00797734,
-0.024302445,
-0.013328641,
0.012415811,
-0.026392695,
-0.018693171,
0.010358636,
0.018878384,
-0.01711887,
0.0017777034,
-0.015795927,
-0.03534901,
0.016801365,
0.004355787,
0.02168302,
0.017780341,
0.020386538,
-0.015002163,
0.024104005,
0.015359357,
0.0052752313,
0.00901585,
0.020545289,
-0.0071968045,
0.0012187604,
-0.015504881,
0.028945971,
0.012243829,
0.014671427,
-0.0075407694,
0.0125679495,
-0.035005048,
0.016338333,
0.0037703847,
0.016788134,
0.00011937485,
0.0071769604,
0.002933624,
-0.021616872,
-0.0008045141,
0.014764033,
-0.012111534,
-0.014816951,
0.012349664,
-0.0016594654,
0.012250443,
-0.019830901,
0.023310238,
0.0038133804,
-0.0171321,
-0.00018438505,
0.0017065952,
-0.005304998,
-0.0022572698,
0.016999805,
0.018203683,
0.0061682174,
0.009518568,
-0.0058804774,
-0.0069917487,
0.020452684,
0.004656756,
-0.026339777,
0.03339106,
-0.01266717,
0.020373307,
-0.016854282,
-0.037598014,
-0.012819309,
-0.006016079,
-0.006780078,
0.0057349536,
0.009875762,
-0.020704042,
0.07688939,
0.014089333,
-0.00079831283,
0.012276902,
-0.036116317,
0.040693697,
-0.0022060059,
0.016166352,
-0.017383458,
-0.016100205,
-0.0048783487,
-0.019090053,
0.032226868,
-0.040561404,
-0.020730501,
0.056251496,
-0.004044895,
0.027490735,
-0.00028463925,
-0.008354379,
0.017462835,
-0.02577091,
0.018494729,
0.003995285,
-0.04106412,
-0.0051925476,
0.04857843,
-0.005420755,
-0.010623225,
-0.050774515,
0.029316396,
-0.002411062,
-0.024858082,
-0.002425945,
0.008116249,
-0.007600302,
0.009101842,
-0.009161374,
0.027755324,
0.018097848,
0.017423147,
-0.009419347,
-0.013150044,
0.00034127772,
-0.00776567,
0.00741509,
-0.006760234,
0.0015255176,
0.005113171
] |
Recent studies have investigated the dendritic actin cytoskeleton of the cell edge's lamellipodial (LP) region by experimentally decreasing the activity of the actin filament nucleator and branch former, the Arp2/3 complex. Here we extend these studies via pharmacological inhibition of the Arp2/3 complex in sea urchin coelomocytes, cells that possess an unusually broad LP region and display correspondingly exaggerated centripetal flow. Using light and electron microscopy, we demonstrate that Arp2/3 complex inhibition via the drug CK666 dramatically altered LP actin architecture, slowed centripetal flow | [
-0.014508007,
0.032352444,
0.011656999,
-0.013790127,
-0.022821737,
0.03511457,
-0.014111464,
0.013277356,
0.008621394,
-0.014193507,
0.010665641,
0.0124159,
0.007855655,
0.008826502,
-0.021782521,
0.01795383,
0.018582828,
-0.0106519675,
-0.0144943325,
0.018828958,
-0.035059877,
0.022903781,
0.011698021,
-0.036372572,
-0.0125936605,
0.009701631,
0.008477817,
-0.036071744,
-0.0047927015,
-0.013461953,
0.007992394,
-0.0046320334,
0.004406414,
-0.014904549,
-0.009578566,
-0.00089393114,
0.023341345,
0.0018425579,
0.003965431,
-0.00419105,
0.015560897,
-0.0027108504,
-0.023792583,
-0.010494717,
0.013591856,
-0.011233108,
0.0060130972,
-0.0078214705,
-0.0019092181,
0.020018589,
0.031121794,
0.007561666,
0.0025228343,
-0.014097789,
-0.0019143459,
-0.013079084,
0.015629267,
-0.010378489,
0.0014494333,
-0.018664872,
-0.003321048,
0.009872555,
-0.00918886,
0.014549028,
-0.0084299585,
0.02427117,
0.002413443,
0.014576376,
0.007199308,
-0.011807412,
0.018774264,
0.027662298,
-0.010166544,
-0.013058573,
0.031532012,
-0.019772457,
-0.023929322,
0.000019722997,
-0.018555481,
0.013673899,
-0.004693566,
-0.010221239,
0.011239945,
0.030848315,
0.00952387,
-0.012183444,
0.008245361,
-0.0033808716,
-0.0063412706,
-0.00010116549,
0.016791549,
0.04422139,
0.019553676,
0.01055625,
-0.009086306,
-0.006142999,
-0.021372303,
0.02991849,
-0.014248203,
-0.034102704,
-0.01201252,
-0.00034761615,
-0.0015759169,
-0.023642171,
-0.011547607,
-0.0068198573,
0.010392163,
-0.0051653152,
0.023478085,
-0.003435567,
-0.017352177,
0.0089564035,
0.013475628,
-0.025966734,
0.027935775,
-0.015137006,
0.015656615,
-0.009981946,
-0.008019742,
-0.0101255225,
0.020141654,
0.049280733,
0.0170787,
-0.016258266,
0.043483,
0.013742268,
-0.0052029183,
0.0048986743,
-0.0076505463,
0.004772191,
0.0047072396,
0.015738657,
0.0040269634,
0.006122488,
-0.012525291,
-0.008375263,
0.010433185,
-0.020975761,
-0.012374879,
-0.038150176,
-0.0046046856,
0.021221891,
-0.007992394,
0.003498809,
0.0063891294,
0.041131087,
0.025378756,
-0.0052473587,
0.002117745,
0.009168349,
-0.0042594196,
-0.018350372,
0.017830765,
-0.0064438246,
-0.016148875,
0.033364315,
-0.013215823,
0.0316414,
-0.029262144,
-0.020510849,
-0.019375915,
0.012422737,
0.00062429893,
-0.02969971,
0.036946874,
0.024503626,
-0.006064374,
0.008094948,
0.0038252731,
0.0036919527,
0.0073565575,
0.00012712453,
-0.020852696,
0.014740463,
-0.010193892,
0.0152600715,
-0.0012742365,
0.010098174,
-0.01634031,
-0.023081541,
-0.01192364,
-0.006871134,
0.011882618,
0.010105011,
-0.0032150755,
-0.02023737,
0.01743422,
-0.020647587,
0.0053533316,
-0.010091337,
0.0033432683,
0.00990674,
-0.030766273,
-0.008252198,
-0.6375319,
-0.049198687,
0.019143458,
-0.012074052,
-0.02279439,
0.02732045,
-0.004703821,
-0.0055686953,
-0.0063105044,
-0.008805991,
-0.0073770685,
0.01714707,
0.014425963,
-0.014986593,
-0.032461837,
-0.037302397,
-0.0043243705,
-0.013872171,
0.032817356,
-0.020770652,
-0.017051352,
0.001062291,
-0.0023057612,
0.006460917,
0.007869328,
0.013790127,
0.041267827,
-0.00912049,
-0.031094447,
0.026486343,
-0.0092367185,
0.014111464,
-0.02727943,
0.016463375,
0.054586206,
-0.0012520164,
-0.019416936,
0.017721374,
0.008334242,
0.042334393,
-0.020948414,
0.0017092373,
0.0134414425,
-0.017242787,
-0.015807027,
-0.010084501,
0.0063275965,
-0.00010367593,
-0.00018705467,
0.011759553,
0.011096369,
-0.008826502,
-0.035716224,
0.01651807,
0.018569155,
0.0077325897,
0.010002457,
-0.026158169,
-0.0054490487,
0.017625656,
-0.00072471664,
0.016969308,
-0.023204606,
-0.021481695,
-0.0133593995,
-0.010706663,
-0.03672809,
-0.008204339,
0.015383136,
0.00023202898,
0.013188476,
0.023915648,
-0.016395004,
0.008183829,
0.008532513,
0.028387014,
0.010843402,
-0.005161897,
-0.031340577,
-0.0068882266,
-0.0024954865,
0.01394054,
-0.025132626,
0.00063882745,
0.012757747,
0.026882885,
-0.015902745,
0.040584132,
0.0030646627,
-0.0073702317,
-0.016053157,
0.016914614,
-0.028250275,
-0.02844171,
-0.034430876,
0.01768035,
0.005654157,
0.0018869981,
0.00040615752,
-0.021632109,
0.004300441,
-0.010193892,
0.0029962931,
-0.027087994,
0.02991849,
0.0030253502,
-0.021837216,
0.013072248,
0.04706556,
-0.036919527,
-0.009701631,
-0.013947377,
-0.0135645075,
-0.009058958,
0.016559092,
-0.024216475,
-0.00090333197,
-0.00019773739,
0.01620357,
-0.048378255,
0.004625196,
-0.013810637,
0.037822004,
0.0013750815,
0.00006345544,
-0.016258266,
0.013728594,
-0.012600498,
-0.015875397,
-0.019375915,
0.007130938,
0.014480659,
0.028168231,
-0.023942998,
0.03590766,
0.035688877,
0.034759052,
-0.009400805,
0.021317609,
-0.048460297,
-0.022370499,
-0.011561281,
-0.0022784134,
-0.02196028,
0.0041602836,
-0.02967236,
-0.021563739,
-0.0047174953,
-0.010022968,
-0.0020203185,
0.001667361,
0.0020220277,
0.0015913,
0.0248318,
0.019594697,
-0.0031791816,
-0.0030971381,
-0.024845473,
-0.008635067,
-0.028851926,
0.012614172,
-0.0158207,
-0.019786132,
0.02570693,
0.009934087,
-0.018076895,
0.015697636,
-0.0048815818,
-0.010795543,
-0.026664102,
0.00008343215,
0.0022664487,
-0.015000267,
0.005746456,
-0.015041289,
0.022917455,
0.0075411554,
0.024107084,
-0.010016131,
0.0002638635,
0.00576013,
-0.0033244668,
0.008730784,
-0.0026903397,
0.019717762,
0.00045123865,
0.038423657,
0.01999124,
-0.01876059,
0.03738444,
-0.014234529,
0.03689218,
0.0042013056,
-0.017174417,
0.0035517951,
-0.00885385,
0.0251463,
0.010016131,
0.018350372,
0.03180549,
0.013092758,
-0.0033911269,
0.013345725,
-0.014125138,
0.006037026,
-0.013995236,
-0.013448279,
-0.021727825,
0.0291801,
0.013434606,
-0.0017622237,
-0.009968272,
-0.011622814,
-0.0038560394,
0.020292066,
0.003599654,
-0.014740463,
-0.018705893,
0.009011099,
0.0065292865,
-0.004809794,
0.004673055,
0.0024373725,
-0.008033415,
-0.0047482615,
-0.001022124,
0.0046217777,
0.036700744,
-0.030957706,
-0.014863528,
-0.031258535,
0.000765311,
0.012621009,
0.04047474,
-0.0049431142,
0.028195579,
-0.002859554,
-0.008915382,
0.039052654,
0.0014032839,
0.005746456,
0.0019792968,
-0.009811022,
0.011964661,
0.010795543,
0.010200729,
0.02409341,
0.028824579,
0.008170155,
0.0067514875,
0.0015024196,
0.012238139,
-0.025994081,
0.004963625,
-0.008703437,
-0.004587593,
0.005442212,
0.030164622,
0.040529437,
0.026390625,
0.00829322,
-0.004105588,
0.015137006,
-0.013933703,
-0.0053123096,
-0.0042662565,
0.01687359,
-0.0051106196,
-0.015861724,
0.016449701,
-0.0062899934,
0.00012979521,
0.026130822,
-0.030137273,
0.011595466,
-0.00070805155,
0.0066933734,
-0.014726789,
0.013256845,
0.014740463,
-0.009147839,
-0.042225,
0.0144122895,
0.00041128523,
-0.0023228535,
-0.016736852,
-0.026117146,
0.035552137,
0.004023545,
0.008881197,
0.002463011,
0.00596182,
0.027347798,
0.010925445,
-0.011547607,
-0.018282004,
0.017584633,
-0.01943061,
0.013974724,
-0.0035928169,
-0.008553023,
0.0031877276,
0.00029356152,
0.0006110524,
0.045616128,
0.006235298,
-0.0027758016,
-0.012484269,
-0.0013708083,
-0.010132359,
-0.0034577872,
-0.003767159,
0.010740847,
0.0011776645,
-0.013161127,
0.0029792008,
0.009428153,
-0.005373842,
0.03623583,
0.011998846,
-0.01869222,
-0.020524522,
-0.0026732471,
-0.013687572,
0.02297215,
0.013414095,
0.006546379,
0.027265754,
-0.0120672155,
-0.009893066,
-0.0037466483,
-0.016230918,
0.015834374,
-0.029754404,
0.0003572306,
-0.02010063,
0.019266523,
-0.011424542,
0.0028424617,
0.037193004,
-0.012292835,
-0.004262838,
-0.0019912615,
0.009646935,
0.029480927,
-0.010221239,
0.0211125,
0.043756478,
0.014808833,
0.013530323,
0.0011836468,
0.012709889,
0.0013742269,
0.0037534852,
0.009182023,
0.001163136,
0.0024937773,
0.01687359,
-0.035306007,
-0.026855538,
-0.00039675672,
0.01588907,
-0.0102075655,
-0.00017872213,
0.015314767,
0.0066865366,
0.009715305,
-0.0031364507,
-0.011848433,
-0.00813597,
0.02171415,
0.012689378,
-0.015574571,
-0.0020476663,
0.03672809,
-0.02868784,
-0.009988783,
-0.01819996,
0.0026817934,
-0.0007311263,
0.0066215857,
0.0077736117,
0.00065292866,
-0.01943061,
-0.0019604953,
0.0041226805,
-0.00495337,
-0.013728594,
-0.027306776,
-0.020210022,
-0.0079855565,
0.007322373,
-0.018883655,
-0.0038765504,
-0.0023228535,
-0.037739962,
-0.043045435,
0.005507163,
0.016859917,
0.020428805,
0.02669145,
-0.011574956,
-0.012969693,
0.03202427,
-0.0016887265,
0.0029057036,
-0.0051448043,
-0.03664605,
0.0039859414,
0.015027615,
0.02198763,
-0.014453311,
-0.003095429,
-0.016600113,
0.0067036287,
-0.014425963,
0.033391662,
-0.024995888,
-0.017092373,
0.021454347,
0.040802915,
0.036946874,
-0.0034406949,
0.0031637982,
-0.012566313,
-0.028906623,
-0.0017793161,
0.0011212598,
-0.015478853,
-0.013229497,
-0.0058592656,
0.01080238,
-0.0068779713,
0.0027313612,
0.0076573836,
-0.016654808,
-0.0107135,
-0.008265872,
0.022890106,
0.022999497,
0.0017793161,
0.0024818126,
0.01006399,
-0.018883655,
-0.014480659,
-0.009537544,
0.011294641,
0.0039209905,
-0.030738926,
0.017721374,
0.0086966,
-0.0035688877,
-0.018117916,
-0.002081851,
-0.019485306,
0.031504665,
0.000766593,
-0.029098056,
-0.01095963,
-0.009428153,
-0.0040338,
-0.0064062215,
-0.01160914,
-0.012860302,
-0.007199308,
0.0043961583,
0.014357594,
-0.01098014,
0.01799485,
-0.03388392,
0.0027997307,
0.037575874,
0.0036543494,
-0.00259975,
0.004197887,
-0.0030219317,
-0.019758783,
0.00374323,
-0.024982214,
-0.026076125,
0.000355735,
-0.008689763,
0.027840057,
0.014466985,
0.044932432,
0.000860601,
0.005712271,
0.008176992,
0.011308314,
-0.0143302465,
0.013947377,
0.012518454,
-0.024818126,
0.03131323,
0.029316839,
0.0063481075,
0.0077599376,
-0.030246664,
0.021085152,
0.023231953,
-0.013332051,
-0.010214402,
0.0044747833,
-0.0167642,
-0.021262912,
0.0005807134,
-0.016613787,
-0.024312193,
-0.028387014,
0.0010187054,
0.013701247,
-0.00813597,
-0.0043517184,
-0.022849085,
0.020743305,
-0.023313997,
0.047284342,
-0.01539681,
0.012094564,
-0.028031493,
-0.022329478,
-0.010193892,
0.008142807,
0.0008999135,
-0.008320567,
0.011752716,
0.008163318,
0.005004647,
-0.016477048,
0.0029997115,
0.017447894,
-0.006170347,
-0.008532513,
-0.03601705,
0.013291029,
-0.01929387,
-0.026431646,
-0.047585167,
-0.001734876,
0.016395004,
0.004256001,
0.015054963,
-0.0016947088,
-0.008758132,
0.02893397,
0.0011716823,
0.0054046083,
-0.019690415,
0.004211561,
0.0083068935,
0.004652544,
-0.019922871,
-0.0005131985,
-0.015492528,
-0.005431956,
0.036536656,
0.036837485,
-0.017065026,
-0.01718809,
-0.008628231,
0.024708735,
0.000092405644,
-0.032489184,
0.010405837,
-0.0065190312,
0.014795159,
0.0018100824,
-0.003907317,
-0.039927784,
0.02626756,
-0.0076095248,
-0.0083068935,
-0.0008452179,
0.0071035903,
-0.03191488,
0.018022198,
-0.0072813514,
0.034266792,
0.003859458,
-0.016572766,
0.014152485,
-0.010597272,
-0.0011614268,
0.013981561,
-0.00959224,
-0.0033894177,
0.010193892,
0.0027245244,
0.009824696,
0.020661261,
0.0158207,
-0.014754137,
-0.0054046083,
0.051742032,
-0.009469175,
-0.007062569,
0.006313923,
-0.0033535238,
0.023560127,
-0.020606566,
-0.0065805637,
0.004789283,
-0.029207448,
0.0040748217,
0.027744342,
0.0013998654,
0.0047858646,
-0.010918608,
-0.022985823,
0.0043038595,
-0.042170305,
-0.002404897,
-0.008354752,
-0.053546987,
-0.023901975,
0.00676858,
0.011759553,
0.010440022,
-0.0038423657,
0.0044166693,
-0.0065121944,
0.018364046,
-0.025898365,
0.03054749,
0.003955175,
0.0030937197,
-0.034950487,
0.008375263,
-0.012805606,
-0.029371535,
0.012627846,
-0.026240213,
-0.039052654,
-0.030684229,
-0.018555481,
0.020893717,
0.0154241575,
0.0076300357,
0.006180602,
-0.0020801418,
0.009434991,
0.0023570382,
-0.008464144,
-0.009831533,
-0.025788974,
0.0045192237,
0.016490722,
-0.021221891,
0.0035586322,
-0.008026578,
-0.023587476,
0.006689955,
-0.0023143075,
-0.0056575756,
-0.009113654,
-0.009058958,
-0.008635067,
-0.004232072,
0.011123717,
-0.013345725,
-0.016996656,
-0.007028384,
-0.0007277078,
-0.0038765504,
0.007322373,
0.0005597752,
0.004761935,
0.003527866,
-0.0063275965,
-0.0027279428,
-0.0009981946,
-0.009947762,
-0.025788974,
0.0070215473,
-0.028988665,
0.024695061,
0.00014784903,
-0.007274514,
-0.0143302465,
-0.008081274,
-0.03858774,
0.00028522898,
-0.007930862,
0.003838947,
-0.007937699,
0.0028681003,
0.00026835027,
0.0056678313,
-0.00885385,
0.0022373917,
0.019362241,
-0.014193507,
0.027716992,
-0.022097021,
0.015683962,
-0.006149836,
-0.025064256,
-0.015752332,
0.03188753,
0.009742653,
-0.0013306413,
0.033610445,
-0.002635644,
0.004789283,
0.0045910114,
0.0068369494,
-0.015465179,
0.008621394,
0.0033449775,
-0.044139344,
-0.0075001335,
-0.0014571248,
-0.00320482,
-0.0062899934,
0.015943766,
-0.009544382,
-0.0074796225,
0.021809869,
-0.011739043,
-0.039544914,
0.015506201,
-0.0033159205,
0.020633914,
-0.006149836,
0.01620357,
0.033090834,
0.022083346,
-0.0008101785,
-0.029043362,
-0.012545803,
-0.018856306,
-0.010898097,
0.005373842,
-0.0014648164,
-0.001721202,
0.004502131,
0.000983666,
-0.013236335,
0.0023502014,
-0.004225235,
0.01900672,
-0.013181639,
0.021932933,
0.0054661413,
0.021823542,
0.0015383136,
-0.0059925863,
0.0045260605,
-0.018049547,
-0.0049362774,
0.030027881,
-0.012470596,
0.0034577872,
0.0052952175,
-0.02360115,
-0.023108888,
-0.014056768,
-0.01781709,
-0.007677894,
0.0069941995,
0.18465233,
-0.015287419,
-0.0006995054,
0.00952387,
-0.021632109,
-0.0005807134,
-0.014084116,
-0.0012648356,
-0.0144943325,
0.010378489,
0.028633144,
0.006912156,
-0.005702016,
-0.0039688493,
0.029344186,
0.000060624512,
-0.018022198,
-0.008580372,
-0.011212597,
0.0046491255,
0.01949898,
0.0030492796,
0.018582828,
0.019772457,
0.03752118,
-0.01743422,
-0.027730666,
0.007151449,
-0.006286575,
0.013790127,
-0.011000652,
-0.0018459763,
-0.0018032454,
-0.0126346825,
0.015013941,
-0.0004142764,
-0.011431379,
0.007342884,
0.01313378,
0.002463011,
-0.0041876314,
-0.01873324,
0.0092367185,
-0.009728979,
-0.005766967,
-0.0010016131,
0.0048986743,
-0.020524522,
-0.0018340116,
0.019895524,
-0.055898897,
0.006334434,
0.033200227,
0.014193507,
0.011417706,
-0.008546187,
0.021372303,
0.01539681,
0.004204724,
0.048487645,
-0.037794657,
0.020387784,
-0.014904549,
0.0052097556,
-0.010105011,
-0.000119753444,
-0.012183444,
-0.011992009,
0.015642941,
-0.02788108,
0.024790779,
-0.020893717,
-0.013755943,
0.003644094,
0.0016929996,
-0.0107135,
0.028578449,
0.017502591,
0.039572265,
0.018869981,
0.027129015,
0.017584633,
-0.01634031,
0.013120106,
0.0069258297,
-0.016053157,
0.018213633,
0.008423122,
-0.023190932,
-0.0017135105,
0.010084501,
-0.01999124,
-0.021372303,
-0.0067890906,
0.033063486,
-0.0076642204,
0.009400805,
-0.012873976,
-0.041213132,
-0.0046422887,
-0.02507793,
0.04608104,
0.031258535,
0.020264719,
-0.021727825,
-0.0093597835,
0.0013853369,
0.018158937,
0.0066489335,
-0.02241152,
0.018172612,
-0.02115352,
0.00748646,
-0.008402611,
-0.0020989436,
0.012313346,
0.030492794,
-0.011445053,
0.035825614,
0.006761743,
-0.012156096,
-0.008976915,
-0.002750163,
0.016053157,
0.0039107352,
0.00015094703,
-0.035470095,
-0.0004057302,
-0.00035893984,
-0.027197385,
-0.01136301,
0.011992009,
-0.006826694,
0.014056768,
-0.016613787,
0.003119358,
-0.0044474355,
-0.016012136,
0.005011484,
-0.010105011,
-0.004406414,
0.0029997115,
0.00831373,
0.0052952175,
-0.0047004027,
0.00741809,
0.025857342,
0.034950487,
-0.020333087,
-0.035579484,
-0.00035210288,
-0.009831533,
-0.0027399075,
0.016641134,
0.015314767,
-0.021085152,
-0.02030574,
-0.0093597835,
0.003326176,
0.0013913192,
-0.03760322,
-0.00656689,
0.02788108,
0.003962012,
-0.0050593424,
-0.015328441,
-0.17349443,
0.0013340598,
0.015916418,
-0.022220086,
0.012443248,
0.025679583,
0.014357594,
-0.0012896196,
-0.015383136,
0.014986593,
0.026486343,
0.013639715,
-0.024777105,
-0.028851926,
0.006539542,
-0.008088111,
0.00015009241,
0.0153010925,
0.011971499,
0.015861724,
0.013256845,
-0.020497175,
0.021194544,
0.009298251,
0.015054963,
0.03973635,
-0.010351142,
-0.019075088,
0.011588629,
-0.025912039,
-0.014795159,
0.009058958,
0.04416669,
-0.0051653152,
0.004789283,
0.013858496,
-0.011356173,
0.0014169578,
-0.014097789,
0.016723178,
0.016654808,
0.041951522,
0.015355788,
-0.006382292,
-0.0011708275,
0.037165657,
-0.012942345,
-0.0335284,
0.009482848,
-0.020196348,
0.006977107,
-0.026732473,
-0.0076163616,
0.00354154,
0.006286575,
0.02115352,
0.011506586,
0.029973187,
-0.01848711,
-0.00038756957,
0.0010904934,
0.0015460051,
0.0291801,
-0.008737622,
-0.0017271844,
-0.022151716,
0.0042286534,
0.01634031,
-0.031094447,
0.013468791,
-0.012737237,
0.0011152774,
-0.011130554,
-0.030738926,
0.01943061,
0.0042765117,
-0.0004755953,
0.015027615,
0.004119262,
0.0068198573,
-0.023327671,
0.014111464,
-0.012313346,
-0.022370499,
-0.015683962,
0.001692145,
-0.01634031,
0.026869211,
-0.009216208,
0.011219434,
0.025816321,
-0.0341574,
0.0066865366,
-0.0034509501,
0.019950218,
0.025871016,
-0.025501821,
0.0041534468,
-0.015588244,
-0.004837142,
0.012901324,
-0.006525868,
-0.0010323793,
0.005107201,
0.023313997,
0.0031227767,
-0.008723947,
0.013079084,
0.049581558,
-0.021645783,
-0.0075411554,
-0.0051789894,
0.007958209,
0.016531743,
-0.013058573,
0.024298519,
0.01904774,
0.00885385,
-0.0072813514,
-0.026746146,
0.062024806,
0.009469175,
-0.00853935,
0.021796195,
0.019088764,
-0.0177077,
-0.1391456,
-0.032872055,
0.007007873,
0.026951255,
-0.017174417,
0.025570191,
-0.0021468021,
0.0105289025,
-0.016230918,
0.038560394,
-0.010768196,
-0.003355233,
-0.01127413,
0.014767811,
0.011896292,
0.0055276738,
0.002902285,
-0.008361589,
-0.023874627,
0.017024005,
-0.00454999,
-0.0036680233,
-0.00300313,
0.015807027,
0.006501939,
-0.008320567,
-0.0047756094,
0.042908695,
0.011629651,
0.02749821,
0.003852621,
-0.004536316,
0.010077664,
0.013776453,
-0.021645783,
-0.045260604,
-0.010166544,
-0.024941191,
0.030656882,
-0.025802648,
0.0075001335,
0.027484536,
0.023956671,
-0.0038423657,
0.0035517951,
-0.022179063,
-0.013585019,
0.0065908195,
0.0019775876,
0.0010016131,
-0.03103975,
-0.010371652,
-0.022097021,
0.011321988,
0.03864244,
-0.009284577,
0.0051516416,
0.008628231,
-0.015629267,
-0.014138811,
-0.025912039,
-0.012033031,
0.009715305,
-0.007438601,
0.037083615,
0.00045123865,
-0.013591856,
-0.030410752,
0.027197385,
-0.015137006,
0.0008982042,
0.005076435,
-0.015314767,
0.0072129816,
-0.01781709,
-0.029863795,
-0.028004145,
-0.015232723,
-0.002989456,
0.002182696,
-0.00788984,
-0.025036909,
0.01120576,
-0.0029877468,
0.025310386,
0.003321048,
0.0020903973,
-0.008764969,
0.014877202,
0.001936566,
-0.008566698,
0.038970612,
0.009674284,
-0.03566153,
-0.0071651232,
0.010850239,
-0.0023433645,
-0.010508391,
0.008457307,
-0.0042730933,
-0.028277623,
0.009612751,
-0.058196113,
0.013790127,
0.008231687,
0.007561666,
-0.0013032935,
-0.029809099,
0.011465564,
0.009537544,
0.001958786,
0.011103206,
-0.03664605,
0.0198545,
0.0016656518,
-0.004020126,
-0.049882382,
-0.036946874,
0.03908,
-0.024544649,
0.015369463,
0.030738926,
0.020114304,
-0.011390358,
-0.002830497,
0.007322373,
-0.01434392,
-0.030383402,
-0.019198153,
0.0073702317,
-0.0014776357,
0.0044474355,
0.0039141537,
-0.042142957,
0.0005106347,
0.009981946,
-0.0018408486,
-0.018774264,
-0.029453577,
0.03938083,
0.009161512,
0.032461837,
-0.0072129816,
-0.040802915,
0.0032287494,
-0.005421701,
-0.0032372957,
-0.015000267,
-0.02602143,
-0.0042867674,
-0.011219434,
-0.01459005,
0.043127477,
0.016189896,
-0.009147839,
-0.038423657,
-0.012149259,
-0.008737622,
-0.0007153158,
-0.0291801,
-0.009113654,
0.0014699441,
0.010098174,
0.011978336,
0.021509042,
-0.015519875,
-0.017981177,
-0.008997425,
-0.043264218,
-0.0072334926,
-0.009558056,
-0.035442747,
-0.008819665,
0.0027740921,
0.0029962931,
0.005596043,
-0.002821951,
-0.010405837,
-0.01577968,
-0.0047004027,
-0.010187055,
0.0010144324,
0.0058319177,
-0.013516649,
-0.013667062,
0.0022185901,
0.029098056,
-0.020210022,
0.005616554,
0.024052389,
-0.0039996156,
0.0031415783,
-0.009838371,
0.029316839,
0.0130380625,
0.022821737,
0.0008281255,
0.025939386,
-0.011848433,
0.00023865227,
0.010187055,
-0.0031774722,
0.0019485306,
0.01687359,
-0.0019057996,
-0.028168231,
0.018610176,
0.012908161,
-0.009981946,
-0.026992276,
-0.00082684355,
0.006638678,
0.011075858,
-0.02279439,
0.016545417,
-0.001559679,
-0.0006811311,
0.013120106,
-0.017174417,
-0.026349602,
-0.005134549,
0.0058079883,
0.018596502,
0.011568119,
0.00061917125,
0.021700477,
0.018405069,
0.01571131,
0.042799305,
-0.0097221425,
0.019116111,
-0.016258266,
0.009414479,
0.0024390817,
-0.050620772,
-0.02012798,
0.011875781,
0.0064574988,
-0.00044525633,
0.00038201455,
-0.04173274,
0.086966,
0.008053927,
-0.022958476,
0.00878548,
-0.029043362,
0.014152485,
-0.0023348182,
-0.0013562798,
0.00217415,
-0.05264451,
0.01799485,
-0.0044952943,
0.01873324,
-0.020032262,
-0.013680736,
0.010925445,
-0.028906623,
0.02942623,
-0.009612751,
-0.022370499,
0.0033825808,
-0.026636755,
0.0036919527,
0.016012136,
-0.019348567,
0.010822891,
-0.0016280486,
-0.0013314959,
0.014918224,
-0.02115352,
0.004738006,
0.0072266557,
-0.03664605,
-0.014863528,
-0.004269675,
-0.005141386,
-0.006939504,
-0.035169266,
0.008655578,
0.015738657,
-0.009291414,
0.02539243,
-0.013208986,
-0.025939386,
0.010522065,
0.017065026,
0.01402942,
-0.014918224,
-0.03019197
] |
The persistence of transcriptionally silent but replication-competent HIV-1 reservoirs in Highly Active Anti-Retroviral Therapy (HAART)-treated infected individuals, represents a major hurdle to virus eradication. Activation of HIV-1 gene expression in these cells together with an efficient HAART has been proposed as an adjuvant therapy aimed at decreasing the pool of latent viral reservoirs. Using the latently-infected U1 monocytic cell line and latently-infected J-Lat T-cell clones, we here demonstrated a strong synergistic activation of HIV-1 production by clinically used histone deacetylase inhibitors (HD | [
-0.030615231,
-0.005907783,
-0.0061093788,
-0.02777239,
0.007920325,
0.0013667514,
-0.00424718,
0.0039533284,
-0.027417034,
-0.0022465975,
0.026255295,
0.017166398,
0.010394145,
0.005063814,
-0.023289444,
-0.015375953,
0.025079887,
-0.016524024,
0.005518259,
-0.017508086,
-0.028401094,
-0.013093478,
-0.0058701974,
-0.033020712,
-0.028455764,
0.004390689,
0.026378302,
-0.041412566,
-0.0370663,
-0.007879321,
0.0045581157,
-0.0038132365,
-0.00236448,
0.002757421,
-0.019872565,
-0.00764014,
0.002967559,
-0.036710944,
0.034223456,
0.014829253,
0.009956784,
0.008781378,
-0.009820109,
-0.0028137995,
-0.000062678366,
-0.0015862859,
0.00060265197,
-0.0012394727,
-0.007592304,
0.025845269,
0.0134556675,
0.0085011935,
-0.008528529,
0.010523986,
-0.022073036,
-0.010831505,
-0.016127666,
0.039936475,
-0.020719951,
-0.025284901,
-0.022073036,
-0.036683608,
-0.0316813,
0.01913452,
-0.0022260963,
0.032173328,
0.01156955,
-0.0018024034,
0.0142825525,
0.009847444,
0.03501617,
0.006187967,
-0.012984138,
0.0071412763,
0.012820128,
-0.02056961,
-0.010394145,
-0.0060854605,
0.02655598,
0.011658389,
0.018738162,
-0.0096355975,
-0.0022517228,
0.018136792,
0.016182337,
0.0091230655,
0.009164068,
0.032063987,
0.030970586,
-0.0036799782,
0.00032972876,
0.021950027,
0.02397282,
0.035754215,
-0.015102603,
0.022893086,
0.014159544,
0.023275776,
0.00060436036,
-0.008467025,
-0.02451952,
-0.0016708536,
-0.025858937,
-0.021813352,
-0.017303072,
0.017644761,
0.0049920594,
0.004134423,
0.01102285,
0.005296162,
-0.04174059,
0.021895358,
-0.008685705,
-0.040209826,
0.044501424,
-0.013072977,
0.021950027,
-0.00026651652,
0.01456957,
-0.015088935,
0.013489836,
0.02413683,
0.016483022,
-0.013072977,
0.029549165,
0.019694887,
-0.023111766,
-0.019612882,
-0.008350851,
-0.0065604066,
0.024382845,
0.010681163,
-0.0036970626,
0.0042335126,
-0.010783669,
0.0130456425,
-0.0096424315,
-0.012246093,
-0.0131413145,
-0.027335027,
0.0024106079,
0.03725764,
-0.013947698,
-0.010646993,
-0.010209633,
0.0033707507,
0.00661166,
-0.009683434,
-0.012710788,
0.009806441,
-0.004841717,
-0.019558212,
0.0062323865,
-0.015854316,
-0.007708478,
0.0045922846,
-0.008289347,
0.005207323,
-0.026364634,
-0.00091999455,
0.00071199203,
-0.01929853,
0.028237084,
0.017111728,
0.0146925775,
0.0247382,
0.0103599755,
-0.006386146,
-0.0034202954,
-0.022742743,
-0.00055396144,
0.025079887,
-0.038077693,
-0.0008918053,
-0.0111868605,
0.022332719,
-0.0045376145,
0.020268923,
-0.019585548,
-0.019339532,
0.0016042244,
0.025708593,
0.012191422,
0.006437399,
-0.0071549434,
0.009922615,
0.01726207,
-0.020022908,
0.0012949969,
-0.017672095,
-0.015867984,
0.008125337,
0.0022414722,
-0.018615155,
-0.6359221,
-0.023029761,
0.004920305,
-0.009082063,
-0.0036799782,
0.018943174,
0.026036615,
0.0040114154,
-0.027540041,
0.017166398,
-0.007086606,
0.013175484,
0.027512705,
-0.011357704,
-0.010674329,
-0.027936399,
-0.009820109,
-0.010605991,
0.024546856,
0.004670873,
-0.013271156,
-0.00032652545,
-0.016906714,
0.013271156,
0.00731212,
0.0055011744,
0.024314508,
-0.011070686,
-0.015854316,
0.019913567,
-0.0105649885,
0.026788328,
-0.018382806,
-0.004916888,
0.05953569,
0.00731212,
0.000060596205,
0.024656195,
0.01462424,
0.035262186,
0.004534198,
0.0035945561,
0.01622334,
0.0051424024,
-0.026282629,
0.018984176,
-0.012136753,
0.0046879575,
0.022387387,
-0.017726766,
0.011371371,
-0.0041754255,
-0.028510435,
0.0057027703,
0.0155126285,
-0.0015657846,
0.015608301,
-0.015922654,
0.01693405,
0.010100293,
0.013585509,
0.01984523,
-0.002108214,
-0.0017263779,
-0.020337261,
0.009717602,
-0.001019084,
0.006300724,
0.0045444486,
0.007277951,
0.0030444388,
0.012943136,
-0.0034869246,
0.005033062,
0.008883884,
0.022401055,
-0.017344076,
-0.018000117,
-0.008159506,
0.025366906,
-0.00091657764,
-0.017508086,
-0.028237084,
0.005094566,
0.006587742,
-0.011446543,
-0.016619697,
0.030697236,
0.0071207746,
0.0153076155,
0.013195985,
0.032966044,
0.01979056,
-0.05179988,
-0.011180026,
0.020801956,
0.0019510377,
0.009833776,
-0.013476169,
-0.002080879,
-0.024724534,
-0.029275816,
0.021909025,
-0.0023610631,
0.0053542485,
-0.011173192,
-0.03039655,
0.008562697,
0.048082314,
-0.021403328,
-0.023453454,
-0.0056925197,
-0.0048724688,
-0.01737141,
-0.002174843,
-0.02777239,
0.024642527,
-0.0017058766,
0.012744957,
-0.036437593,
0.009451086,
-0.0018997844,
0.003290454,
-0.008631035,
0.0045581157,
0.005603681,
0.008788211,
-0.009000058,
-0.0029453493,
-0.0052517424,
0.007318954,
-0.002321769,
0.013018307,
-0.009184569,
0.0408932,
-0.0005048438,
0.027348695,
0.0028753032,
0.0018451144,
-0.014651575,
-0.0290298,
-0.008166339,
0.009000058,
0.022250712,
-0.014911258,
-0.018136792,
0.0075444677,
-0.01280646,
0.0031913645,
-0.007715312,
0.016428351,
-0.0023883982,
-0.007400959,
0.020104913,
0.031052591,
-0.017781436,
-0.012000077,
-0.039827134,
-0.0017169814,
-0.008084334,
-0.021430662,
0.0021270069,
0.0033656254,
0.0032853286,
-0.013558174,
-0.0027676716,
0.018710827,
0.015075268,
-0.02650131,
-0.040537845,
0.015485293,
-0.021047972,
-0.0063143913,
0.020842958,
0.019927235,
0.013804189,
-0.008542196,
-0.0097381035,
-0.001119882,
0.0042540138,
-0.009813275,
-0.0068132556,
-0.0017297948,
-0.012567279,
0.033786096,
0.002446485,
0.016783707,
-0.0099499505,
0.019872565,
0.021649342,
-0.020856626,
0.018929508,
-0.022250712,
0.014596905,
0.003239201,
-0.0153076155,
-0.0032767865,
0.027253022,
0.027280359,
0.037476324,
-0.0024123162,
0.0011275699,
0.007817818,
-0.020979634,
0.0067380844,
-0.015744977,
-0.003912326,
-0.028565105,
0.027061678,
-0.0099499505,
0.002839426,
0.011487545,
-0.008617368,
0.012785959,
-0.02523023,
0.010435147,
0.0024840706,
0.0049066376,
-0.019913567,
-0.0026258712,
-0.019175522,
0.010715331,
0.0060581258,
-0.036765613,
-0.009170902,
0.002559242,
0.010605991,
0.021895358,
-0.0022534314,
-0.020747287,
-0.006095711,
-0.012956804,
0.0085011935,
0.010031955,
0.0072711175,
0.005962453,
0.015690306,
-0.004694791,
-0.00005744627,
-0.004476111,
-0.015553631,
-0.012382768,
-0.015553631,
0.0011335495,
0.0075581353,
0.012854297,
0.02655598,
0.012444272,
-0.026870333,
0.011829234,
-0.003915743,
0.020350927,
-0.008562697,
-0.0076333066,
0.0075991377,
-0.00019721796,
0.010482984,
0.018861169,
0.040811196,
0.028319089,
0.0034407966,
0.005907783,
0.0059043663,
-0.011467044,
-0.012164087,
-0.0077426466,
0.0018656157,
-0.008378186,
0.000629987,
0.024205167,
-0.011159525,
-0.014528567,
0.01637368,
-0.030232541,
-0.0005044167,
0.021061638,
-0.014432895,
0.01462424,
0.02441018,
0.0037824844,
-0.002138966,
-0.023152769,
0.029549165,
0.010633326,
-0.0033280398,
-0.013407831,
-0.018232463,
-0.003293871,
-0.002866761,
-0.00360139,
0.011057019,
0.017070726,
0.016319012,
0.008849715,
-0.0023320196,
-0.02166301,
0.02930315,
-0.00089778483,
0.011842901,
-0.0039225766,
-0.013428332,
-0.006803005,
-0.017234735,
-0.010277971,
0.029439826,
0.0053952513,
0.0038064027,
-0.005207323,
-0.0023063929,
-0.014473897,
0.011897571,
0.0043565203,
0.0015760352,
-0.005989788,
0.0047187093,
0.0020637945,
-0.009915781,
0.021922693,
0.025981944,
-0.00011393154,
-0.010271137,
-0.025038885,
-0.000032353568,
-0.013708517,
0.02639197,
0.010646993,
-0.020132247,
0.013086645,
-0.0115968855,
0.034496807,
-0.0033690422,
-0.031134596,
0.015526296,
-0.030478556,
-0.0023508123,
-0.0045376145,
-0.00027676715,
-0.011405541,
0.022360053,
0.025025219,
-0.008248345,
-0.02451952,
-0.02006391,
-0.0020057077,
0.0051424024,
0.008180007,
0.017672095,
0.026842998,
0.034551475,
-0.03282937,
0.025435243,
0.013394164,
0.002683958,
-0.022496728,
-0.0049032206,
0.0033280398,
0.0028787202,
0.016182337,
-0.0040865866,
-0.045321476,
0.0023354364,
0.013708517,
0.010435147,
-0.012567279,
0.0241915,
0.026542312,
0.009184569,
0.014268884,
0.019899901,
0.005897532,
-0.0077563142,
0.015034266,
-0.017453415,
-0.015075268,
0.029057134,
-0.024259837,
-0.035590205,
0.010674329,
0.014159544,
0.00467429,
-0.008180007,
-0.009410083,
0.00494764,
-0.00703877,
-0.021786017,
-0.025120892,
0.0048861364,
-0.013954531,
-0.018615155,
-0.035125513,
0.010339474,
-0.021471664,
-0.008152672,
0.0071071074,
-0.0037312314,
-0.025025219,
-0.014774582,
0.027061678,
0.00009503193,
0.009211904,
0.015129938,
-0.0035262187,
-0.013202818,
0.020186918,
-0.03039655,
-0.004366771,
-0.008631035,
-0.047480945,
0.011296201,
0.0027010425,
-0.009888446,
-0.023275776,
-0.0015666388,
0.005036479,
0.024546856,
-0.015485293,
0.031489953,
-0.0023798558,
-0.023549126,
0.018574152,
0.036464926,
0.014924926,
-0.0033194975,
-0.0024174415,
-0.021471664,
-0.02682933,
0.00945792,
-0.025202896,
-0.006515987,
-0.02786806,
0.0009592886,
0.013571842,
-0.024328174,
-0.0177541,
0.00022957152,
0.0022004698,
-0.019161854,
-0.003857656,
0.031517286,
0.020706283,
0.0149932625,
0.00037991419,
0.007961327,
0.013284824,
-0.012416936,
-0.0002434526,
0.019544546,
-0.0094305845,
-0.0059180334,
0.010216467,
0.018246131,
-0.0020125415,
-0.015580966,
0.005149236,
-0.0188475,
0.057075538,
0.013776854,
-0.0220457,
-0.02495688,
0.0034425051,
0.013093478,
-0.0010242093,
0.029330485,
-0.03170863,
0.0068474244,
0.0036116405,
-0.0026890833,
0.0035364693,
0.008514862,
-0.029166475,
0.006218719,
0.021622008,
-0.015949989,
-0.023672134,
-0.0032511598,
-0.0038918245,
-0.008747209,
-0.0007538488,
-0.031134596,
-0.006328059,
0.010353141,
0.011467044,
0.029603835,
0.008227844,
0.031134596,
0.0053952513,
-0.013975034,
0.014104875,
0.016018327,
-0.0053542485,
-0.010995515,
0.015772311,
-0.018984176,
0.020637946,
0.026760992,
-0.004527364,
0.030669902,
-0.031981982,
0.025038885,
0.009505756,
-0.0019629968,
-0.03056056,
0.008118504,
-0.026966006,
-0.03170863,
0.014501233,
-0.015129938,
-0.01209575,
-0.043271348,
0.016975053,
0.028756449,
0.007441961,
0.019968238,
0.008965889,
0.026214292,
-0.0012975596,
0.019052515,
0.0022073034,
-0.008822381,
-0.017603759,
0.00731212,
-0.0033280398,
0.00758547,
0.0392531,
-0.004383855,
-0.004127589,
0.012034246,
-0.022141373,
0.016537692,
0.013469335,
-0.016127666,
-0.019599214,
-0.037202973,
-0.028510435,
-0.015799645,
-0.007817818,
-0.03419612,
-0.03299338,
0.0069225957,
0.004182259,
-0.0016947717,
0.0008482401,
0.0061982176,
-0.010421479,
0.03261069,
-0.004168592,
0.027034342,
-0.01294997,
0.019435205,
0.025339572,
0.005350832,
-0.02721202,
-0.014309887,
-0.0014410685,
0.010770001,
0.024232503,
0.015403288,
-0.013612844,
-0.012970471,
0.026925003,
0.020022908,
0.013913529,
-0.031653963,
0.013243821,
-0.020692617,
-0.005152653,
-0.019694887,
-0.023289444,
-0.02963117,
0.013421499,
-0.016633365,
0.037366983,
0.002193636,
0.00041600497,
-0.02253773,
0.013647012,
0.0026583315,
0.015854316,
-0.011856568,
-0.017275738,
-0.016401017,
-0.02924848,
0.004927139,
0.0010387311,
-0.014268884,
0.036683608,
-0.02242839,
-0.0051253177,
0.013230153,
-0.002190219,
0.0033810013,
0.016811043,
-0.01033264,
0.037640333,
-0.024642527,
-0.0052722436,
0.016975053,
0.0053303307,
0.009102564,
0.018451143,
-0.002291017,
-0.007879321,
-0.01578598,
-0.003628725,
0.02924848,
0.011145858,
-0.019940903,
-0.012293929,
-0.008289347,
0.0014906132,
-0.022018366,
-0.03501617,
0.021252984,
-0.04277932,
-0.0013078102,
-0.0071822787,
0.0023901064,
0.026952337,
-0.0007525675,
0.0039806636,
-0.017426081,
0.029849852,
-0.019749558,
0.020801956,
0.0062255524,
-0.0070729386,
-0.00082005083,
0.011760896,
-0.010394145,
-0.011009183,
0.0066868314,
-0.020678949,
-0.03039655,
-0.03184531,
-0.026925003,
0.008036498,
0.0111868605,
0.009485255,
0.025571918,
0.0061059617,
0.02348079,
0.00764014,
-0.013879361,
0.013811023,
-0.03359475,
-0.009006891,
0.014323555,
-0.023467122,
0.0059009492,
-0.0017665261,
0.009799607,
0.013886195,
-0.02897513,
-0.012717621,
-0.016811043,
0.009273408,
-0.018984176,
0.0035159679,
0.02357646,
-0.022278048,
-0.00923924,
-0.0035911393,
0.014528567,
-0.004216428,
-0.019763226,
0.010687996,
-0.012355433,
-0.0001373158,
-0.0003690229,
0.0057608574,
0.0068542585,
-0.029822515,
-0.024095828,
-0.0018997844,
-0.013927197,
0.026405636,
0.023767807,
-0.011323536,
-0.01627801,
-0.019257527,
-0.047180258,
0.019640218,
0.0057984428,
-0.0028804287,
0.018833835,
0.031981982,
-0.0043223514,
-0.014637908,
-0.013291657,
0.027663048,
0.009075229,
-0.019667553,
0.011631055,
-0.008754043,
0.01968122,
0.0050672307,
-0.04220528,
0.0010677745,
0.02908447,
0.0059180334,
-0.0020877128,
0.019886233,
-0.025366906,
0.0075991377,
0.0036355588,
0.028483098,
-0.004862218,
0.011521715,
0.015498961,
-0.020091245,
-0.005706187,
0.03244668,
0.024000155,
-0.008309849,
0.005060397,
-0.004445359,
0.020829292,
-0.008829214,
-0.008132171,
-0.02908447,
0.019339532,
-0.020391932,
0.012457939,
0.0075308,
0.012990972,
0.019530877,
0.018574152,
-0.012662952,
0.004978392,
-0.010886175,
-0.010127628,
-0.003932827,
0.022182375,
-0.0022619737,
-0.002010833,
0.010380477,
-0.0061196294,
-0.012990972,
-0.007974994,
0.012061581,
-0.009177736,
-0.024054825,
0.0060615423,
-0.00026737075,
-0.015184608,
0.0075308,
0.0045752004,
-0.018218797,
-0.0027625463,
-0.006037624,
0.004896387,
-0.0037038962,
0.015211944,
0.00015333242,
-0.013940864,
-0.005846279,
0.006748335,
-0.02786806,
-0.0055045914,
0.021854354,
0.19254793,
-0.019476207,
-0.0017050224,
-0.015635636,
-0.026952337,
0.007592304,
0.02468353,
-0.006406647,
-0.008015997,
0.01759009,
0.02611862,
0.008036498,
0.00024708302,
-0.010120794,
-0.0064271484,
-0.021362325,
-0.02568126,
-0.014528567,
-0.01973589,
-0.019489875,
0.0078109843,
0.01682471,
0.013647012,
-0.013004639,
0.021840688,
-0.024997883,
-0.017330408,
0.007025102,
0.0073052864,
0.0012454522,
-0.029658506,
0.0026805412,
-0.007339455,
-0.0058838646,
0.012177755,
0.0046640392,
-0.03348541,
0.0024413597,
0.00045316352,
0.003912326,
-0.003372459,
0.018150458,
-0.022934088,
-0.000914015,
-0.0057266885,
0.0125262765,
-0.00085080275,
-0.009280242,
0.011740395,
-0.022073036,
-0.02391815,
-0.015088935,
-0.00065048825,
0.008542196,
0.0027369198,
-0.0018382806,
0.02495688,
0.020200586,
-0.024341842,
0.035890892,
-0.009546759,
-0.0040455842,
-0.027075345,
0.018669825,
-0.0040626684,
0.03392277,
-0.016975053,
0.0096355975,
0.011535382,
-0.027143683,
0.022688074,
-0.009512589,
-0.010537653,
0.005661768,
-0.007947659,
-0.0050501465,
0.013175484,
0.02100697,
0.02820975,
0.009833776,
0.014309887,
-0.008412355,
-0.024724534,
0.020419266,
-0.0069055115,
-0.036492262,
0.0188475,
0.010558154,
-0.023849811,
0.019503543,
0.0027369198,
-0.030041195,
-0.023672134,
-0.0009225572,
0.009915781,
-0.00092426565,
-0.007175445,
-0.016264342,
0.015908986,
-0.020378264,
-0.020186918,
0.0735859,
0.020870294,
0.00800233,
-0.003830321,
0.0037893183,
-0.0007107107,
0.003476674,
-0.00007565183,
-0.02326211,
0.016428351,
-0.049503736,
0.0125262765,
-0.02050127,
-0.0028223416,
0.024779202,
0.012143586,
-0.012403269,
0.04513013,
0.0051355683,
0.01338733,
-0.017713098,
-0.004308684,
0.023234773,
-0.017945446,
-0.009587761,
-0.026624318,
-0.0035330523,
-0.012129919,
-0.034551475,
0.0051799878,
0.00818684,
-0.005241492,
0.008043332,
0.009259741,
0.007674309,
0.0027352113,
0.0013428333,
-0.030095866,
0.0072506163,
-0.0008098002,
-0.010079792,
0.027307693,
0.009170902,
0.0068747597,
-0.03755833,
0.016961385,
-0.006410064,
-0.014104875,
-0.011610554,
0.0041173385,
-0.012471607,
-0.016633365,
-0.0091299,
0.0049613076,
-0.0065945755,
-0.015075268,
-0.011385039,
-0.0062870565,
0.04420074,
-0.026801994,
0.01809579,
0.018273465,
-0.0033707507,
-0.014364557,
-0.014610573,
-0.17374144,
0.005227824,
0.015553631,
-0.01258778,
0.04452876,
0.018082121,
0.016182337,
0.009874779,
-0.016209671,
0.032966044,
0.007510299,
0.010756333,
-0.033950105,
-0.02248306,
-0.001054107,
0.000991749,
-0.021540003,
0.040045816,
0.041084547,
-0.006471568,
0.04045584,
-0.031079927,
0.021157311,
-0.029549165,
0.012902133,
-0.0055045914,
0.007571803,
0.008487526,
-0.005624182,
-0.008467025,
0.008084334,
0.0048998035,
0.0387064,
-0.0143782245,
0.012669786,
-0.01393403,
0.014309887,
0.0026685821,
-0.010230134,
0.019899901,
0.031763304,
0.017617425,
0.010209633,
-0.015826982,
-0.0071959463,
0.043353353,
0.0007841736,
-0.013216486,
-0.006526238,
0.008924887,
0.0056993533,
-0.024437515,
0.014173212,
0.007605972,
0.018587818,
-0.0071891122,
0.004219845,
0.022688074,
0.0053337472,
-0.015211944,
-0.008296181,
0.005200489,
0.047617618,
-0.0105649885,
0.021526335,
-0.039061755,
-0.00478363,
-0.01418688,
-0.015881652,
0.02413683,
-0.03594556,
0.0019971654,
-0.008296181,
-0.010168631,
-0.0012172629,
0.0087130405,
-0.024697198,
0.0021047972,
-0.0021731348,
-0.0022534314,
-0.02166301,
0.0043941056,
-0.01435089,
-0.018218797,
-0.0043565203,
-0.022551399,
0.011501213,
0.0047904635,
0.009936282,
0.0034988837,
0.0029333902,
-0.0046298704,
0.007865654,
-0.010271137,
0.017180065,
0.020815624,
0.00709344,
0.00796816,
-0.019448873,
0.0005022811,
0.015129938,
-0.028537769,
-0.0025131141,
-0.0063451435,
0.03392277,
-0.014200547,
-0.030095866,
0.0022585567,
0.05207323,
-0.007974994,
-0.021211982,
0.031626627,
0.0072096135,
0.040947873,
0.0031366944,
0.027007008,
-0.0139681995,
-0.0063246423,
0.0012497234,
-0.02413683,
0.06636945,
0.0072916187,
-0.027963733,
0.01853315,
-0.0066799973,
-0.013524005,
-0.13514438,
-0.016346347,
0.010592324,
-0.0139681995,
-0.02166301,
0.04496612,
0.016346347,
0.023344114,
-0.037038963,
0.0062597212,
-0.028483098,
-0.007134442,
0.0037619832,
-0.013489836,
-0.0020364595,
0.011815566,
0.0049920594,
0.01484292,
-0.029986525,
0.03662894,
-0.0026036615,
0.0057437727,
0.004479528,
-0.028483098,
0.014036537,
0.019257527,
-0.022250712,
0.021293987,
0.014747248,
0.030533226,
0.011268865,
-0.0010412937,
-0.00017063037,
-0.010435147,
-0.0150616,
-0.010250635,
-0.011398707,
0.0043701874,
0.015293948,
-0.020760953,
0.0028650525,
0.020514939,
0.00048989494,
0.013148149,
0.031927314,
-0.012020579,
0.013503504,
-0.0057608574,
-0.00424718,
-0.016291676,
-0.04277932,
-0.024601525,
-0.051171172,
-0.0088155465,
0.011692558,
-0.031380612,
0.026186956,
0.037476324,
-0.0033365819,
-0.022592401,
0.013694849,
0.008446524,
-0.0036765612,
-0.003473257,
0.009861112,
-0.0059419516,
0.0011070686,
-0.008938554,
0.009519423,
-0.020091245,
-0.003912326,
-0.028483098,
-0.020829292,
-0.00403875,
-0.014200547,
0.016975053,
-0.00920507,
-0.034442134,
0.007626473,
0.005460172,
-0.024341842,
-0.016346347,
0.022934088,
-0.0166607,
0.03941711,
-0.0065433225,
-0.0018621988,
-0.010592324,
-0.023316778,
-0.0069909333,
-0.027499039,
0.050105106,
-0.031380612,
-0.035043504,
-0.015225611,
0.017303072,
-0.019981906,
-0.0029709758,
0.012546778,
0.019981906,
-0.020186918,
-0.013893028,
-0.06713483,
0.008056999,
-0.0044009397,
-0.0017357743,
-0.0048451335,
-0.012970471,
-0.019380534,
-0.00048177986,
-0.0047050416,
-0.0013095187,
-0.011979576,
-0.010544487,
-0.0134556675,
0.011535382,
-0.023494456,
-0.002446485,
0.033950105,
-0.011166359,
0.010387311,
0.02078829,
0.010414646,
0.0084055215,
-0.010927177,
0.0088087125,
0.014829253,
-0.0010113961,
-0.004582034,
0.035316855,
-0.011959075,
-0.0038132365,
-0.00049416604,
-0.03539886,
-0.0043565203,
-0.009854278,
-0.0051082335,
0.008624202,
0.025339572,
0.010018288,
0.0093280785,
0.03359475,
-0.01753542,
-0.031107262,
-0.011275699,
0.015977323,
-0.0015290531,
0.021567337,
-0.02919381,
0.016688034,
-0.0056378497,
-0.012143586,
0.040073153,
0.024478517,
-0.008227844,
-0.01517094,
-0.02413683,
-0.007899823,
-0.0118224,
-0.01418688,
-0.018710827,
-0.00725745,
0.013770021,
-0.0007226698,
0.008829214,
0.024833873,
-0.0034903414,
-0.0091230655,
-0.0027471704,
-0.0026463724,
0.0050467295,
0.002967559,
-0.021854354,
-0.007899823,
0.007899823,
-0.0166607,
0.016947716,
-0.0048143817,
-0.007783649,
0.0017340658,
-0.0062563047,
0.003823487,
-0.004493195,
-0.027143683,
-0.003235784,
0.0054635885,
0.03936244,
-0.0071276086,
-0.008180007,
0.020214254,
-0.00612988,
-0.012799627,
0.0048861364,
0.0009635597,
0.012717621,
0.026706323,
-0.0045786174,
0.015375953,
0.0005915471,
0.0052483254,
-0.00854903,
0.031790636,
0.008323516,
0.025722262,
0.011426042,
-0.03159929,
-0.008562697,
0.04551282,
-0.034551475,
-0.03359475,
-0.009355414,
-0.000038226328,
0.022797413,
-0.00028253315,
0.0033160807,
0.0018741578,
-0.009587761,
0.00016924227,
-0.0039499113,
-0.010236968,
-0.026733657,
0.027348695,
0.017863441,
0.021266652,
0.009300743,
-0.0074146264,
0.023412451,
0.0063451435,
0.014132209,
-0.023836145,
0.026405636,
-0.018000117,
0.006967015,
-0.0018690325,
-0.024273505,
-0.017303072,
-0.030041195,
0.0018194878,
0.017344076,
0.021362325,
-0.03518018,
0.08249711,
0.021034304,
-0.03282937,
0.011719894,
-0.02941249,
0.0236448,
0.017904444,
0.010298472,
-0.018984176,
-0.022196043,
0.015854316,
-0.02963117,
0.03392277,
-0.035426196,
-0.0016213089,
0.016469354,
0.006779087,
0.014132209,
-0.014774582,
-0.0150616,
0.0011232988,
0.00085977203,
-0.0049613076,
-0.01962655,
-0.03952645,
-0.025790598,
0.020760953,
-0.0146925775,
-0.0029709758,
-0.01841014,
0.03056056,
-0.006205051,
-0.027540041,
-0.023193771,
0.0060649593,
-0.011890737,
-0.02661065,
-0.012375934,
0.02561292,
0.010906676,
0.010353141,
0.0074966312,
0.0068815933,
-0.024943214,
0.006355394,
0.0012830378,
-0.006478402,
-0.0075308,
0.003239201
] |
Many human tumours show centrosome aberrations, indicating an underlying deregulation of centrosome structure, duplication or segregation. Centrosomes organize microtubule arrays throughout the cell cycle, thereby influencing both tissue architecture and the accuracy of chromosome segregation. But what are the origins of centrosomal abnormalities in tumours, and what impact do they have on the generation of invasive, genetically unbalanced cells during cancer progression? | [
-0.006222283,
0.0030252612,
0.01006584,
-0.040600397,
-0.024111347,
0.018239068,
-0.0087111965,
0.005894965,
-0.0037560554,
0.0053537562,
0.008795457,
0.010227878,
-0.00010431236,
0.024552092,
-0.019522414,
0.02650952,
0.0422856,
0.0018115918,
-0.012852903,
-0.007181552,
-0.027118783,
0.012664939,
-0.0062449686,
-0.012042711,
-0.013001979,
0.027818792,
0.023165042,
-0.034792934,
0.004770417,
-0.018433513,
0.006455619,
0.010033431,
0.0022328922,
-0.023424303,
-0.013151054,
0.0056032958,
0.028259536,
0.00093982404,
0.0056843148,
-0.018537218,
0.0005347275,
0.009534352,
-0.011381593,
-0.008594529,
-0.005800983,
0.028207684,
0.005457461,
0.001673859,
-0.007920448,
0.01027973,
0.021661323,
0.03087808,
-0.039381865,
-0.0059857066,
-0.012036229,
-0.03767074,
-0.004271338,
0.013429761,
-0.016164973,
-0.016553866,
0.022115031,
-0.006682473,
-0.021920584,
0.012224194,
-0.01988538,
0.008477861,
0.018213142,
-0.0035292013,
-0.0045759706,
-0.017500171,
0.042985607,
0.02622433,
-0.0055870917,
-0.02542062,
0.0082056355,
-0.030152148,
-0.03637443,
-0.015089037,
-0.010480658,
0.023165042,
0.0076417415,
-0.0021291876,
0.02466876,
0.021972438,
-0.008192672,
0.01858907,
0.0012274425,
-0.010085284,
0.02542062,
0.011141776,
0.010493621,
0.011977895,
0.008166746,
0.02269837,
-0.006491267,
0.0051204204,
-0.023074301,
0.033833664,
-0.015750155,
-0.02202429,
-0.011070479,
0.012852903,
-0.007913967,
-0.02046872,
-0.0068509933,
-0.006591731,
0.0450597,
-0.0074148877,
0.01149826,
0.005058846,
-0.04275227,
0.006747288,
-0.012788088,
-0.015231631,
0.008335267,
0.019392783,
0.016839053,
0.012107526,
-0.026574334,
-0.010914922,
0.021000206,
0.042130042,
0.018213142,
-0.019457597,
0.03352255,
0.0064264517,
-0.0136890225,
0.01145289,
0.003687999,
-0.0274299,
0.014777922,
0.012814014,
0.016126083,
0.0108760325,
-0.005651907,
-0.015931638,
0.007350072,
-0.0033282733,
-0.025329879,
-0.056519073,
0.014894591,
0.028596576,
-0.025913216,
-0.00146807,
-0.0065171933,
0.027481752,
0.018796481,
0.012237157,
0.0076871123,
-0.00009747636,
0.013961248,
-0.008827864,
0.009683428,
0.004329672,
0.012509381,
0.019807601,
0.007952856,
0.018213142,
-0.042389303,
-0.0052241255,
0.0049389373,
0.029918812,
0.009417685,
0.0036361467,
0.028129905,
0.030800302,
-0.007453777,
0.0057037594,
0.014285325,
-0.022815038,
0.027352119,
0.007162107,
-0.020870576,
0.015957564,
-0.012386233,
0.015452003,
-0.023411341,
0.032070685,
-0.058541313,
-0.005593573,
-0.014363104,
0.023216894,
0.0017581191,
0.0018780277,
-0.03150031,
-0.0021599748,
0.016813127,
0.004326431,
0.005399127,
-0.0153482985,
-0.016022379,
-0.0034514228,
0.0013627448,
-0.017409429,
-0.6288654,
-0.015905712,
0.010759365,
-0.0076741492,
0.0020027973,
0.03868186,
0.0059176506,
0.019820565,
-0.02299652,
-0.014285325,
-0.0136890225,
0.032615133,
0.008218599,
-0.017227946,
-0.0131964255,
-0.037411477,
-0.00373337,
-0.009780651,
0.025705807,
-0.004472266,
-0.0012355446,
0.017863138,
-0.007038958,
0.0018002491,
-0.0030528076,
0.0026914615,
0.035000343,
-0.0037787408,
0.004031521,
0.042233746,
-0.035207752,
-0.0034125333,
-0.021881696,
-0.0029393807,
0.04093744,
0.010888996,
-0.009923246,
0.025394693,
0.0030560484,
0.03339292,
0.0067408066,
-0.014090879,
0.018264994,
-0.011459371,
-0.032200314,
-0.0056940373,
-0.0056324624,
-0.041170772,
0.020611312,
0.00536996,
-0.007868595,
-0.009676946,
-0.021233542,
0.011640855,
0.016839053,
0.0007263381,
0.026535446,
-0.032407723,
0.00031982374,
0.021790953,
0.002043307,
0.03258921,
-0.003960224,
-0.030515114,
0.000981954,
0.015464966,
-0.008160265,
0.008024152,
0.0076547046,
0.00566487,
0.015866822,
0.036867026,
-0.013339019,
0.00032326704,
0.0075315554,
0.037904076,
0.0007101343,
-0.0016608959,
0.007123218,
-0.0027238692,
0.0020530294,
-0.0013384391,
-0.030981785,
0.016424235,
-0.006909327,
-0.0127038285,
-0.028259536,
0.012606605,
-0.002080576,
-0.007265812,
0.0122047495,
-0.0029474825,
0.021376135,
-0.058074642,
-0.007842669,
0.027066931,
-0.0017289522,
0.014246436,
0.0028178517,
-0.03168179,
-0.010409361,
-0.019522414,
0.0040217987,
-0.0019444635,
0.025329879,
0.005953299,
-0.0120816,
0.01002695,
0.030255852,
-0.014363104,
0.007998226,
0.0063745994,
-0.021635396,
-0.020144641,
0.010888996,
-0.013079758,
-0.015037185,
0.038707785,
-0.00039962775,
-0.017279798,
0.011096405,
0.0054898686,
0.00826397,
-0.030281778,
0.029166952,
0.0012728134,
-0.007123218,
0.007025995,
-0.009197312,
-0.014492734,
-0.014259399,
-0.0042616157,
0.015076074,
-0.020546498,
0.015283483,
0.0077972985,
0.002006038,
-0.0028453982,
-0.013818654,
-0.021713175,
-0.028285462,
-0.008678788,
0.01560756,
-0.015464966,
-0.016139047,
-0.007745446,
-0.04853381,
0.00474125,
0.0032148464,
0.006883401,
-0.016813127,
0.016579792,
-0.008043597,
0.012139934,
0.017526098,
0.0020951594,
-0.0025099784,
-0.0356485,
-0.0008701474,
-0.028052127,
0.006079689,
0.010169544,
-0.026198404,
0.004119022,
-0.012496418,
-0.01598349,
-0.021077985,
-0.024215052,
-0.016722387,
-0.033885516,
-0.0050199567,
-0.019146483,
-0.030904006,
0.034792934,
-0.01838166,
0.02337245,
-0.0030673912,
-0.003083595,
-0.0079723,
-0.00310466,
0.013948285,
-0.011880672,
-0.01330013,
-0.011835301,
0.030722523,
0.020040937,
0.028622502,
0.0108695505,
0.003746333,
0.029348435,
-0.01862796,
0.008626936,
0.0027416935,
0.00001400115,
0.0021453914,
-0.024526166,
0.00027971918,
0.031370677,
-0.010150099,
0.03175957,
0.022944668,
-0.0041125403,
-0.004786621,
-0.0049648634,
0.023009485,
-0.0010718855,
-0.0059468173,
-0.020326125,
-0.011388075,
-0.0030803543,
0.0021794194,
0.011990858,
0.012139934,
0.0049907896,
0.0035972574,
-0.009936209,
0.012677902,
-0.026833596,
-0.0026963227,
0.008938051,
-0.028985469,
0.01002695,
0.017694619,
-0.010441769,
0.001392722,
0.018757591,
0.0059597804,
-0.0043069865,
0.004388006,
0.0044690254,
-0.014259399,
0.0222317,
0.004945419,
0.026250256,
0.019327966,
0.036452208,
0.005483387,
-0.010299175,
0.04111892,
-0.014985332,
0.006222283,
0.018277956,
-0.0019007131,
-0.0020238624,
0.018770555,
-0.0031370677,
0.033859592,
0.019807601,
-0.0047801393,
-0.01711128,
-0.002941001,
-0.020546498,
-0.02072798,
0.0023301155,
-0.0052694962,
-0.0014332316,
0.012729755,
0.016787201,
0.054393124,
0.004449581,
0.0028518797,
-0.038941123,
0.022685407,
0.0017435356,
-0.007525074,
0.0070713656,
0.03258921,
-0.008899162,
-0.0063745994,
0.008827864,
-0.008665825,
-0.007745446,
0.023165042,
-0.02999659,
0.0041805967,
0.010227878,
-0.001975251,
0.004728287,
0.016398309,
0.012639013,
-0.018355735,
-0.02337245,
0.008244526,
0.018692777,
0.008529713,
-0.025537288,
-0.009501945,
0.017992768,
0.0024095143,
0.0013100823,
0.0044657844,
0.0015345057,
-0.016385345,
-0.007304701,
-0.025978032,
-0.015840895,
-0.0021615953,
-0.007375998,
0.018965,
-0.008114894,
-0.0061088563,
-0.015827933,
0.011238999,
0.0148557015,
0.013559392,
0.015581634,
-0.018887222,
-0.009754725,
-0.017927954,
-0.019911306,
-0.015750155,
-0.024565056,
-0.016242752,
-0.00019859859,
-0.006539879,
-0.016255714,
0.014920517,
-0.014972369,
0.014168657,
0.0055773696,
0.002001177,
-0.027637308,
0.0014324214,
0.007920448,
0.025822476,
0.03958928,
-0.012237157,
-0.00255859,
0.006831548,
0.012412159,
-0.004718565,
-0.019937232,
0.019263152,
-0.023566898,
-0.012425122,
-0.03984854,
0.01744832,
0.000897694,
0.011601966,
0.033859592,
0.0048935665,
-0.002710906,
0.0051463465,
0.01455755,
-0.005823668,
-0.0013935321,
0.05449683,
0.051541246,
0.012937164,
0.0017159891,
-0.0036555913,
0.018420551,
-0.0028713243,
0.007363035,
-0.024409499,
0.03800778,
-0.0019849732,
0.025822476,
-0.018939074,
-0.034041073,
0.017098315,
0.023359489,
-0.008737123,
-0.010389917,
0.007162107,
0.014246436,
0.016359419,
-0.0012298732,
0.009631576,
-0.015231631,
0.011420482,
-0.0056713517,
-0.016579792,
-0.017992768,
0.008905643,
-0.030204,
-0.0080565605,
-0.032822542,
0.014168657,
-0.023657639,
-0.0141945835,
-0.0039699464,
-0.027922496,
-0.007317664,
0.009417685,
-0.01296309,
-0.0034579043,
-0.002668776,
0.011939006,
-0.010001024,
-0.01598349,
-0.011828819,
-0.027066931,
-0.007233404,
-0.004161152,
-0.049778264,
-0.02361875,
-0.007479703,
0.022270588,
0.017564988,
-0.0034935528,
-0.005995429,
-0.007790817,
0.027870644,
0.013650133,
-0.024137273,
-0.0146871805,
-0.01543904,
-0.013650133,
-0.004582452,
0.00046140497,
0.00028052938,
0.0015126306,
0.01761684,
-0.014816812,
-0.04073003,
0.019729823,
0.0028032681,
-0.019250188,
0.015568671,
0.026198404,
0.026379889,
-0.0074861846,
-0.011977895,
0.0038954085,
-0.035129976,
-0.024098383,
-0.0043653203,
-0.011679744,
-0.009663983,
-0.018342772,
0.013650133,
-0.019898344,
-0.022646518,
-0.0094825,
-0.025692845,
-0.0046764347,
0.0060019107,
0.013222352,
0.019327966,
0.013779765,
0.010273249,
0.012664939,
0.0052241255,
-0.01300846,
-0.021065021,
0.024279868,
-0.0048093065,
-0.016437197,
0.025031727,
-0.010091766,
0.010117692,
-0.035104048,
-0.039252236,
-0.007330627,
0.046174526,
0.0032197074,
-0.0070130317,
-0.0046472675,
-0.0014510559,
0.019224262,
0.0029442417,
0.005512554,
-0.012658457,
0.0010281351,
0.00074497255,
-0.0058333906,
-0.025187284,
0.0060148737,
-0.0356485,
-0.012295491,
0.039692983,
0.006792659,
0.011524187,
0.010305656,
0.034326263,
-0.012600123,
-0.02022242,
-0.0008620455,
-0.02579655,
-0.0121982675,
-0.010901959,
0.028155832,
0.030826228,
0.034818858,
-0.00230743,
0.041067068,
0.00005767562,
-0.005470424,
-0.0044917106,
0.002576414,
0.030255852,
-0.014985332,
0.017279798,
0.005130143,
0.016826091,
0.015413114,
-0.029296583,
0.01900389,
0.03603739,
-0.010720476,
-0.033496626,
0.0062611722,
-0.054600533,
-0.039667055,
0.013287167,
-0.010357508,
0.009113052,
-0.03419663,
-0.003435219,
0.007849151,
0.015114963,
0.006248209,
-0.003704203,
0.018679813,
0.00545422,
0.024461351,
-0.023644676,
0.0146871805,
-0.020572424,
-0.02001501,
0.0053764414,
-0.017409429,
0.013034387,
-0.0211428,
0.011835301,
0.020676129,
-0.004216245,
0.0025261822,
0.023437267,
-0.00385976,
-0.001694924,
-0.013740876,
-0.023178006,
-0.036400355,
-0.0048222695,
-0.021544656,
-0.033004027,
-0.0041546705,
0.0015053388,
-0.019055743,
0.021389099,
0.0024727094,
-0.012075119,
0.01313161,
0.005126902,
0.010901959,
-0.021168726,
-0.0018764073,
-0.0058042235,
-0.009138978,
-0.014000137,
-0.007862114,
-0.016346456,
0.006384322,
0.03175957,
0.0055741286,
-0.012924201,
0.00025845162,
0.024928022,
-0.01157604,
-0.0074343323,
-0.040807806,
-0.0013902914,
0.0010743161,
-0.0012339242,
0.009015829,
-0.008918606,
-0.024681723,
0.015750155,
-0.030489188,
-0.002017381,
-0.001015172,
-0.008840827,
0.004501433,
0.018187216,
-0.022283552,
0.038863342,
-0.0038532785,
-0.022426145,
-0.0037009623,
-0.011323259,
0.011945487,
0.0044528213,
-0.0034254966,
0.026859522,
-0.015970526,
0.005071809,
0.0222317,
0.0055384804,
-0.013559392,
-0.021440951,
-0.021427987,
0.050374568,
-0.022296514,
0.0013222352,
0.015037185,
0.017863138,
0.0010378574,
-0.00031617787,
-0.0015831174,
0.00010755314,
-0.029763255,
-0.010934366,
0.0113686295,
0.02823361,
0.014790885,
-0.011725115,
-0.013663096,
0.01002695,
-0.036685545,
-0.017940916,
0.0056616296,
-0.02945214,
-0.03536331,
0.009981579,
0.04324487,
0.026859522,
-0.005570888,
-0.009391759,
-0.036270726,
0.031733643,
-0.009164904,
0.018731665,
0.006675991,
0.014324214,
-0.033004027,
0.0014324214,
-0.0029312787,
-0.0025440063,
0.009443611,
-0.01271031,
-0.039952245,
-0.005084772,
0.007829706,
0.019470561,
0.011563077,
-0.015076074,
0.0017629802,
0.00897694,
0.0170335,
0.0051625506,
-0.045085628,
0.0070130317,
-0.016514977,
-0.002407894,
-0.004644027,
-0.034818858,
-0.01581497,
-0.021207616,
-0.011627892,
0.0010119312,
-0.008957495,
-0.0012752439,
0.015490892,
0.0023430786,
-0.015231631,
0.007901004,
-0.0052921814,
-0.03935594,
-0.0038241115,
-0.0024808114,
-0.00059427664,
-0.00574913,
-0.0057167225,
0.0016754793,
-0.0033007269,
0.008024152,
-0.0062190425,
-0.00005220682,
0.0041935598,
-0.012353824,
-0.034818858,
0.002589377,
-0.033704035,
0.018433513,
-0.005885243,
-0.0151927415,
0.0025148394,
-0.0025666917,
-0.037152216,
-0.032692913,
0.04174115,
0.0073111826,
0.0067408066,
0.03839667,
-0.0063000615,
0.012580679,
0.010726957,
0.01573719,
0.009929727,
-0.0035356828,
0.0035421643,
-0.0063065435,
0.006637102,
0.00398615,
-0.006708399,
-0.00049300253,
0.024850244,
0.0052630147,
0.008788975,
-0.010733439,
0.009430648,
0.020520572,
-0.00027627585,
0.023670603,
-0.0140131,
-0.0022328922,
0.037852224,
-0.029218804,
0.00032610275,
-0.009164904,
0.000102337515,
0.013494576,
0.014401993,
-0.011342703,
0.0039342977,
0.011264925,
0.016981648,
-0.016048305,
0.0046083783,
0.005068568,
0.013287167,
0.04399673,
0.0030787338,
0.018148325,
0.0063616363,
0.014272362,
0.0030900766,
-0.02001501,
-0.016242752,
-0.0075315554,
0.0023236338,
-0.012891793,
-0.009573242,
-0.01686498,
-0.007609334,
-0.013870507,
-0.0024905337,
0.004290783,
-0.004258375,
-0.046822682,
0.035000343,
-0.00012385828,
0.016385345,
0.0009787133,
-0.006993587,
-0.017668692,
-0.02958177,
0.008238044,
-0.0028389166,
-0.023165042,
0.015620523,
-0.0041676336,
-0.0015426077,
0.003950502,
-0.0066695097,
0.01363717,
-0.024228016,
-0.0025034968,
0.17318688,
-0.020157605,
-0.005531999,
0.018368699,
-0.007375998,
-0.026859522,
0.023929864,
0.015011258,
-0.016955722,
0.0076158154,
0.016826091,
0.009981579,
0.0027141469,
-0.0016430716,
0.03909668,
-0.012457529,
-0.023683565,
-0.0105714,
-0.0036685544,
0.0009317221,
0.011167702,
-0.014116805,
-0.0051722727,
0.0014632088,
0.029815108,
-0.019016853,
-0.034144778,
-0.007123218,
0.00095926865,
0.0027335915,
-0.019185374,
-0.008562121,
-0.0113686295,
-0.017720545,
-0.006857475,
0.009391759,
-0.0007615815,
0.007849151,
-0.0050167157,
-0.017085353,
0.009696391,
-0.012237157,
0.015957564,
0.009339906,
0.0013441104,
0.0069741425,
-0.01858907,
-0.017992768,
0.016489051,
0.0005877951,
-0.033470698,
0.0016835813,
0.021350209,
0.02521321,
0.0010354269,
0.005084772,
0.03958928,
-0.0038856862,
-0.0032553559,
0.035104048,
-0.018977964,
0.00016153225,
-0.016203862,
0.0155168185,
-0.0074343323,
0.013935322,
-0.019742787,
0.013572355,
0.02768916,
-0.016035343,
0.006549601,
0.0057070004,
-0.026729891,
-0.000013634031,
0.0003771449,
-0.018200178,
0.046641197,
-0.0003674226,
0.01254179,
0.011310296,
0.010480658,
0.013429761,
-0.021155763,
0.0018585831,
-0.0011666782,
-0.018939074,
0.023683565,
0.027041005,
0.00096899096,
-0.017927954,
0.004388006,
-0.015698303,
0.0027449343,
-0.015283483,
0.026522482,
0.0005310816,
0.03214846,
-0.008166746,
-0.019444635,
-0.025135431,
-0.029374361,
0.079437815,
0.017564988,
-0.024253942,
-0.0064621004,
-0.002650952,
0.0048903255,
0.0064880266,
0.00255859,
-0.00981954,
-0.008251007,
-0.03380774,
0.011919561,
0.0026120627,
-0.004958382,
0.024266904,
0.0135205025,
-0.03284847,
0.037152216,
-0.020611312,
-0.008257489,
-0.03523368,
0.021492803,
0.007265812,
0.02026131,
-0.00025237515,
-0.03087808,
0.00608293,
-0.00834823,
-0.023994679,
0.00078305166,
0.00050029426,
-0.009787133,
0.023774307,
-0.006031078,
-0.033496626,
0.028285462,
-0.015490892,
-0.02521321,
-0.010312138,
-0.013663096,
-0.018757591,
0.005596814,
0.004501433,
-0.021907622,
-0.019470561,
0.013948285,
0.022983558,
-0.017422393,
-0.05760797,
-0.0072593302,
-0.026172478,
0.010240841,
0.007110255,
0.009320462,
-0.030592892,
-0.018135363,
-0.0373337,
-0.008017671,
0.022815038,
-0.017500171,
0.007304701,
0.033081807,
0.011550114,
-0.00078305166,
-0.005169032,
-0.15980898,
-0.00017084947,
0.020909464,
-0.01581497,
0.013740876,
0.0054153306,
-0.0066565466,
0.011057516,
-0.0025877568,
0.007181552,
0.03191513,
-0.017253872,
-0.046459716,
-0.008497305,
0.004673194,
-0.010383435,
-0.009294535,
0.025978032,
0.032900322,
0.00011413595,
0.005373201,
-0.0239169,
0.03800778,
0.025524324,
0.0058755204,
0.016826091,
-0.015529782,
0.003574572,
-0.009138978,
-0.009864911,
-0.0155168185,
-0.017163131,
0.019846492,
0.0020141401,
0.0098778745,
-0.0020514089,
-0.016061269,
-0.03087808,
-0.009242683,
-0.014946443,
0.022815038,
0.015283483,
0.02453913,
-0.002650952,
0.0012752439,
0.056363516,
-0.003192161,
-0.03150031,
0.022970594,
-0.027222488,
0.026885448,
-0.00017986288,
0.019859454,
0.014803849,
0.016774239,
0.0252521,
0.032952175,
0.00029389755,
0.007408406,
0.0067602512,
-0.0013627448,
-0.019820565,
0.035467014,
-0.013403835,
-0.0048773624,
-0.020909464,
0.0008960736,
0.0061445045,
-0.041352257,
0.0058463537,
-0.019703897,
0.005739408,
0.020585386,
-0.018485365,
0.010772328,
0.00880842,
-0.029918812,
0.009573242,
-0.010720476,
-0.00872416,
-0.026574334,
0.040678177,
-0.02462987,
-0.0021470117,
-0.01838166,
0.0072009964,
0.0015385568,
0.017526098,
0.0023819678,
-0.007220441,
0.013176981,
-0.0076287785,
-0.018109437,
-0.0033072084,
0.02496691,
0.029607698,
-0.021363173,
-0.016813127,
-0.0068250666,
-0.0323818,
0.029478066,
-0.002479191,
-0.02059835,
0.013533466,
0.04376339,
0.022620592,
-0.015905712,
0.00792693,
0.034378115,
-0.00028559307,
-0.022789111,
0.010500103,
-0.01111585,
0.007946374,
0.0018569627,
0.040367063,
0.012451048,
0.026211368,
0.010590845,
-0.023022449,
0.069067344,
-0.017474245,
-0.020144641,
0.020909464,
0.00398615,
-0.0100399135,
-0.13035683,
-0.011336222,
-0.018096473,
0.031370677,
-0.033444773,
0.01388347,
-0.022918742,
0.019833528,
-0.0071880333,
0.034067,
-0.026055811,
-0.021013169,
-0.009929727,
-0.0130214235,
-0.026548408,
0.0034384597,
0.014324214,
0.0019558063,
-0.015089037,
0.015724229,
0.011051035,
-0.0016276779,
-0.0022085865,
-0.01363717,
0.0064296927,
0.0045500444,
-0.042804122,
0.01849833,
0.014648291,
0.014544587,
0.00025278024,
-0.00520144,
0.008225081,
-0.000130036,
-0.0125029,
-0.016852017,
-0.00030301223,
-0.04464488,
0.0016803405,
-0.01669646,
-0.014272362,
0.021622434,
0.023359489,
0.013001979,
0.009223239,
-0.01585386,
-0.028726207,
0.013572355,
0.024772465,
-0.011446408,
-0.022452071,
-0.0071685887,
-0.0038921677,
-0.030385483,
-0.0018958519,
-0.010817698,
0.016177936,
0.02483728,
-0.000053574022,
-0.007440814,
-0.009800096,
-0.0053472747,
0.011232518,
0.033496626,
0.025537288,
-0.0062028384,
0.0040801326,
-0.01371495,
0.022348367,
-0.03310773,
0.004462544,
-0.021039095,
-0.027248414,
-0.02232244,
-0.019289078,
0.0015174918,
-0.0064296927,
-0.007525074,
0.00482551,
-0.013164018,
0.0011221175,
-0.0075963708,
0.012489937,
0.0059306137,
0.028596576,
0.0068445113,
0.0024338202,
-0.008153783,
0.02151873,
0.015037185,
-0.0045889337,
0.04920789,
-0.01934093,
-0.006562564,
-0.008341748,
0.0043491167,
0.011595484,
0.0046116193,
0.0123667875,
0.029063247,
-0.02626322,
-0.008503787,
-0.042778198,
0.027300267,
0.0046796757,
0.00385976,
0.004582452,
-0.0065852497,
0.019561302,
0.0019363615,
0.0015863582,
0.03725592,
-0.011802893,
0.0038694823,
0.0066306205,
-0.017811285,
-0.040289283,
-0.029711403,
0.0065301564,
-0.0068250666,
-0.018057585,
0.024422461,
-0.0026298868,
0.004371802,
0.005301904,
0.019107595,
0.010947329,
-0.013585318,
0.0017419152,
0.02714471,
-0.015400151,
0.008834346,
0.02789657,
-0.012392714,
-0.017513134,
-0.0054282937,
-0.00012325063,
-0.014570513,
-0.017214984,
0.012515863,
0.0048773624,
0.037307773,
-0.017798323,
-0.016502013,
0.015477929,
0.0064880266,
0.0010629734,
0.020079827,
-0.019872418,
0.008562121,
0.003125725,
0.01527052,
0.028052127,
0.017124241,
0.006747288,
-0.035259604,
-0.0026655353,
0.0036004982,
-0.0092102755,
-0.013228834,
-0.012483455,
-0.025265062,
0.011355666,
0.02420209,
-0.007492666,
0.014376067,
-0.0034838305,
-0.0055514434,
-0.031552162,
0.002164836,
-0.00700655,
-0.035985537,
-0.0038338338,
0.02068909,
0.0153482985,
-0.0102019515,
-0.0032877636,
0.0024062735,
-0.02613359,
0.00965102,
-0.0027919256,
0.008931569,
0.009456574,
0.011096405,
-0.0102084335,
0.008199154,
0.046381935,
-0.020313162,
-0.0036231836,
0.030800302,
-0.00026756627,
-0.0049681044,
-0.017500171,
0.02370949,
0.004498192,
0.01778536,
-0.0006473443,
0.0122047495,
-0.012464011,
0.006792659,
0.009456574,
0.020922428,
0.0056227404,
-0.0035778128,
-0.0019233985,
-0.019703897,
-0.0135205025,
0.023852086,
-0.023411341,
-0.0323818,
0.00662738,
0.01405199,
0.0090612,
0.013215871,
0.028311389,
-0.0155168185,
0.00046950692,
0.008192672,
0.012010302,
0.0062611722,
0.001745156,
0.0138575435,
0.024279868,
0.0025618307,
0.0055773696,
0.008166746,
0.015802007,
0.011900117,
0.019652044,
-0.033963297,
0.009838985,
-0.00083936006,
0.028544724,
-0.0071556256,
-0.047470834,
-0.0044204136,
-0.0051949583,
-0.033678107,
0.025628028,
0.012483455,
-0.011601966,
0.0768452,
0.0016049925,
-0.0070324764,
0.0200539,
-0.032278094,
0.014777922,
0.0028000274,
0.005813946,
-0.03650406,
-0.03033363,
0.015724229,
-0.0065301564,
0.014376067,
-0.021103911,
-0.0161909,
0.02378727,
-0.017539062,
0.019846492,
-0.0010086905,
0.0066889543,
0.020183532,
-0.02072798,
0.012464011,
0.019950196,
-0.0137019865,
0.0039667054,
0.025109505,
0.018277956,
-0.007492666,
-0.01866685,
0.0064037666,
-0.01963908,
-0.035726275,
-0.008017671,
-0.016514977,
-0.0024662279,
0.0011107748,
-0.013001979,
0.030826228,
0.016022379,
-0.019574266,
0.017176094,
-0.012826977,
-0.012327898,
-0.017876102,
-0.00977417,
0.023800233,
-0.020753907,
-0.022633554
] |
QT intervals were measured over RR intervals ranging from 500 ms to 1000 ms in 13 normal male subjects, 13 male diabetic subjects without and 13 with autonomic neuropathy. There was a close linear relationship between QT and RR in all subjects. The slope of the regression line was significantly greater in the autonomic neuropathy group than the normal group. Thirty-two male diabetic subjects with varying degrees of autonomic dysfunction had repeat QT measurements 3 (range 2–6) years later. QT and QTC lengthened significantly at the second visit, unrelated to age or time between recordings, but which corresponded with changes | [
-0.00799913,
-0.005264834,
0.031260364,
-0.036097962,
-0.0065301033,
0.00007132544,
0.015327832,
-0.02004712,
-0.017233951,
0.008235752,
-0.008400072,
0.03244347,
0.012895886,
-0.00820946,
0.0001701746,
-0.0096029,
0.020691259,
0.025134489,
0.021466851,
-0.0011395639,
-0.01660296,
0.037701733,
-0.022281881,
0.0044366578,
-0.011193523,
0.00985924,
-0.015945677,
-0.029288515,
0.0036446324,
-0.005573757,
0.032259434,
0.0015158581,
-0.041829467,
-0.016366338,
0.0014632755,
-0.029814342,
0.0019225518,
0.0063164863,
0.016405774,
-0.029630302,
0.0033225638,
0.005577043,
-0.008610403,
0.019560732,
-0.001828889,
0.008945617,
0.00661555,
-0.022518504,
-0.0067174286,
0.019271528,
-0.012435788,
0.011147514,
-0.010943756,
-0.0021723192,
0.013355983,
-0.008945617,
0.021861222,
0.01599826,
-0.0051005133,
-0.029314807,
-0.0016226666,
0.0033357095,
-0.022452775,
-0.005764369,
-0.014131577,
-0.022755126,
0.0028213859,
0.02113821,
0.018246166,
0.0028443907,
0.018877158,
0.024437768,
-0.00006444451,
0.017378554,
0.051636126,
-0.02213728,
-0.0074470127,
-0.013500586,
-0.0012808796,
0.007624479,
0.01409214,
-0.03665008,
-0.029577719,
0.032338306,
-0.011397282,
-0.0032469763,
-0.025686607,
0.006424938,
-0.026225578,
0.0018502506,
0.00136304,
-0.0070526428,
0.01974477,
0.006720715,
0.0111146495,
-0.001837105,
-0.002288987,
0.024003962,
-0.0013942608,
-0.011397282,
0.0027638737,
0.0036939285,
-0.007893965,
-0.019731626,
-0.0076376246,
-0.010273328,
-0.0134217115,
-0.006862031,
-0.0018666828,
-0.016852727,
0.0028608227,
0.02760587,
-0.013224527,
-0.023819923,
0.006536676,
0.004739008,
0.018601099,
-0.0077756536,
-0.0011518878,
-0.034126114,
0.03643975,
-0.007506168,
0.040409736,
-0.01729968,
0.013737207,
0.013362557,
-0.009944687,
-0.0011839304,
0.00250589,
-0.017891234,
-0.0048376005,
0.020283742,
0.02234761,
0.015143792,
-0.014565384,
0.009267685,
-0.001435341,
-0.0063756416,
-0.022308173,
0.00043955777,
-0.0034967437,
0.0034178698,
-0.030287584,
-0.02555515,
0.003601909,
0.027842494,
0.00916252,
0.0067437203,
0.0332585,
-0.017680904,
0.0060009905,
-0.0052122516,
0.00087665074,
0.0006153809,
0.024608662,
0.0040981574,
0.0073089832,
0.011180378,
-0.048796665,
-0.00306951,
-0.010141871,
0.0087878695,
-0.001781236,
0.0035657585,
0.0019981393,
0.0028246723,
0.015012336,
-0.024661245,
0.024293168,
-0.011265825,
-0.01127897,
0.04451118,
0.006730574,
0.030681955,
0.026541073,
0.0013047061,
0.0048441733,
-0.014460218,
-0.03462565,
-0.024109127,
-0.02002083,
0.024109127,
0.015446142,
0.023938235,
0.0012422642,
0.018495934,
0.028342027,
0.012330622,
-0.0024368754,
-0.0027704465,
0.006720715,
-0.0024204433,
-0.009878959,
-0.03665008,
-0.6566517,
-0.0057380777,
0.023859361,
-0.0050052074,
0.0048474595,
0.010306192,
0.018219875,
0.023057476,
-0.0074535855,
0.018338187,
-0.0027622303,
0.030366458,
0.0163269,
-0.021926949,
-0.019521294,
-0.012291186,
-0.01271842,
-0.00050035643,
0.013132508,
0.013829228,
-0.012159729,
0.0080188485,
-0.016471503,
0.028131697,
0.0073681385,
0.009754075,
-0.004768586,
-0.011430145,
-0.018180437,
0.011699631,
-0.016865874,
-0.0030580075,
0.00941886,
0.011870525,
0.042539332,
-0.035572138,
-0.00038697515,
0.01302077,
0.0033258502,
0.051846456,
-0.016458359,
0.0003454842,
0.020822715,
-0.019981394,
-0.027526997,
-0.0015051772,
-0.016616106,
0.0077887997,
0.0011182021,
-0.0161823,
0.016366338,
-0.00072752975,
-0.01853537,
0.017063057,
0.035335515,
-0.0016226666,
0.0019028332,
0.012488371,
0.00354604,
0.010496804,
0.00045311422,
0.00041511506,
-0.00067617954,
-0.005235256,
-0.0002442216,
0.011522165,
0.005922117,
-0.0005767655,
0.003317634,
-0.014723131,
0.0035000301,
0.02211099,
-0.015143792,
0.012889313,
0.03283784,
0.01953444,
0.023188932,
0.02676455,
-0.021059336,
-0.007959693,
-0.014473364,
0.01439449,
-0.0015142149,
-0.005192533,
0.026567364,
0.008255471,
-0.002512463,
0.01232405,
-0.012310904,
0.0087878695,
-0.015340977,
0.010930611,
0.0134874405,
-0.025581442,
-0.024687536,
0.042118672,
-0.019692188,
0.007755935,
0.005462019,
-0.03948954,
0.0034770253,
0.004492527,
-0.0001743853,
-0.0067963027,
-0.0060305684,
0.02295231,
-0.00013186733,
-0.008511811,
0.025923228,
-0.0022561227,
-0.0022462634,
-0.0066221226,
0.017759778,
0.0029216213,
-0.005225397,
-0.03764915,
0.020678112,
0.014473364,
0.00021669788,
-0.028210571,
-0.0061587384,
-0.0015273605,
0.0338632,
-0.02234761,
-0.016879018,
0.009839522,
0.00872214,
0.020244306,
0.008853598,
-0.034099825,
-0.01590624,
0.003641346,
0.01662925,
-0.010529668,
0.0006831632,
-0.0024746691,
0.026698822,
-0.0075587505,
-0.0054061497,
-0.04167172,
-0.027421832,
-0.005330562,
-0.00043586057,
-0.00009237902,
0.017010475,
-0.023188932,
-0.028552359,
-0.0037990937,
0.0050676493,
0.002512463,
-0.0052122516,
-0.009083646,
-0.017036766,
0.009031064,
0.014407636,
-0.011338126,
-0.0036939285,
-0.02715892,
-0.015932532,
-0.01599826,
0.011903389,
0.007322129,
-0.0031549567,
-0.034362737,
-0.0110094845,
-0.02818428,
-0.0026126986,
0.00890618,
-0.017917525,
-0.01944242,
0.0066582733,
-0.01914007,
0.004173745,
-0.029893216,
-0.006641841,
0.0091296565,
-0.01950815,
-0.011732495,
-0.0038878268,
-0.026974881,
0.019915665,
0.000890618,
-0.02083586,
-0.0017056485,
0.041960925,
0.002831245,
0.0010220745,
-0.021046191,
-0.011035776,
0.032154266,
-0.034678232,
0.010707134,
-0.035913926,
-0.00035904066,
-0.0045056725,
0.006816021,
0.0047225757,
-0.006816021,
0.0066254092,
0.027684746,
0.01302077,
-0.004200036,
0.008833879,
-0.0012866308,
0.013369129,
-0.007880819,
0.009760647,
-0.02434575,
0.045562834,
0.0123963505,
0.012343768,
0.016287465,
-0.00057553314,
-0.022781417,
-0.03118149,
0.021519434,
-0.010003842,
0.0061521656,
0.00009576814,
0.00046297346,
0.011850806,
-0.0018666828,
0.01630061,
0.021085627,
-0.01116066,
0.010240464,
-0.0011987193,
0.007381284,
-0.014381344,
-0.0054587326,
-0.030944867,
-0.00005448257,
-0.008058285,
0.01041793,
0.002647206,
0.054475587,
-0.015919385,
0.0029396967,
0.0035098894,
0.023911944,
-0.00041901768,
-0.0067075696,
0.016879018,
-0.015551307,
0.007124944,
-0.01899547,
0.023517573,
0.011154086,
0.00855782,
0.021374833,
0.024437768,
0.022820855,
-0.02241334,
0.005416009,
0.00015425602,
0.0050873677,
0.025147634,
-0.0048540323,
0.018233022,
0.02304433,
0.021203939,
0.0018666828,
-0.0041540265,
-0.01772034,
0.0046009785,
-0.011824515,
0.037097033,
0.014368199,
0.013303401,
-0.0066747055,
-0.0036643508,
0.002307062,
-0.0043446384,
-0.0332585,
0.017943816,
0.0034310154,
0.007532459,
-0.0032551924,
0.011344698,
0.042355295,
0.00045516825,
-0.039174046,
0.024201147,
-0.0025009606,
-0.007013206,
-0.014867733,
0.006720715,
0.011732495,
0.0042197546,
0.014946608,
0.0024713827,
-0.0027523711,
0.00588268,
-0.006520244,
-0.0025420408,
-0.024989886,
0.032101683,
-0.018141001,
-0.0021033045,
-0.016773853,
0.00070370326,
0.02899931,
0.0014912101,
-0.012981333,
0.021111919,
0.015051773,
-0.019849936,
-0.0053732856,
-0.0088733155,
0.015958823,
0.015170083,
-0.025108198,
-0.0075653233,
0.01890345,
0.006273763,
0.024161711,
0.003378433,
-0.0030136409,
0.032496054,
-0.012205739,
-0.036702663,
-0.01953444,
-0.020402053,
-0.016550377,
0.034941144,
0.024056545,
0.008130587,
0.010523096,
-0.016471503,
0.014683695,
-0.01587995,
-0.019363547,
0.032522347,
0.017562592,
-0.026238723,
-0.007124944,
0.021427415,
0.01899547,
0.004048861,
0.013204808,
0.026304452,
-0.01974477,
0.0009193741,
0.0069869147,
-0.019797353,
-0.009530598,
0.026619948,
0.039962787,
0.0149597535,
-0.03154957,
0.017786069,
0.01602455,
0.0338632,
-0.0023119918,
0.028289445,
0.037149616,
-0.015735347,
0.012521234,
-0.014723131,
-0.007571896,
0.009563463,
0.012067709,
0.012251749,
0.008314625,
0.025936374,
0.023859361,
0.0009407358,
0.0018223162,
0.023096912,
-0.01488088,
-0.011035776,
-0.00051021564,
0.007230109,
-0.009175666,
0.00480145,
-0.0026340603,
-0.024017109,
-0.0020375762,
0.010214172,
0.012172875,
-0.02134854,
-0.021611454,
-0.015380414,
0.0074535855,
-0.0026899292,
-0.018167293,
0.021598307,
-0.0042854827,
-0.012935323,
-0.015643327,
-0.019863082,
-0.01853537,
-0.016248027,
0.005478451,
-0.005853102,
-0.02322837,
0.009806657,
0.014775714,
0.011982263,
0.003036646,
0.019126926,
0.006888322,
-0.00049049716,
0.021151356,
-0.02183493,
0.018311895,
0.0040652934,
0.004913188,
-0.0031188063,
0.020296888,
0.003251906,
0.005606621,
0.01369777,
0.016458359,
0.010490231,
-0.046982564,
0.022544796,
-0.0090442095,
-0.0022561227,
-0.0065333894,
0.009063927,
0.036203127,
0.011528738,
0.001733583,
-0.002433589,
-0.029630302,
0.0023004892,
-0.018745702,
0.0074601583,
0.0012225457,
-0.01853537,
0.010799154,
0.006415079,
-0.04167172,
0.0055474658,
-0.013316547,
-0.008472374,
0.01153531,
0.04064636,
0.024687536,
0.008472374,
0.008294907,
0.0039075455,
-0.0134874405,
-0.023609594,
0.008715568,
0.024017109,
-0.0061883163,
-0.012955042,
0.0384116,
-0.014144722,
-0.016879018,
-0.034546778,
0.00872214,
0.015590745,
0.017378554,
0.00669771,
-0.004834314,
-0.03360029,
0.0002512052,
-0.025449984,
0.0013991904,
0.007282692,
0.011817942,
-0.01016159,
0.015945677,
-0.0067634387,
0.0009193741,
0.035598427,
-0.026304452,
-0.018785138,
-0.008183169,
-0.0068817493,
0.017772922,
-0.0141052855,
0.022741979,
-0.036702663,
-0.008196315,
-0.015354123,
-0.013342838,
-0.013217954,
-0.021585163,
0.007078934,
0.03320592,
0.022242445,
0.0012775932,
-0.0049723433,
0.01932411,
-0.00545216,
0.012817012,
0.012251749,
-0.0011436718,
-0.0055638975,
0.006822594,
-0.010214172,
0.0037563704,
0.009372851,
-0.0011757143,
0.0074864496,
0.030918576,
-0.010266755,
-0.004643702,
-0.008991627,
-0.071354605,
0.019468712,
0.013816081,
0.0074075754,
0.0041014436,
-0.022544796,
-0.018509079,
0.035545845,
0.0045056725,
-0.010477086,
-0.0071052257,
0.016077133,
0.0016826435,
0.009326841,
-0.014486509,
0.025029324,
0.0037300792,
-0.015682764,
-0.017325971,
-0.02936739,
0.011929681,
0.008715568,
0.0032009666,
0.012494943,
0.0019373406,
-0.020651821,
-0.011969117,
-0.019731626,
-0.006224467,
-0.0100695705,
0.0062211803,
0.0056329123,
-0.0073352745,
-0.021716619,
-0.003904259,
0.0038943999,
0.016786998,
-0.011706204,
0.016103426,
-0.022820855,
0.000052788015,
0.022097843,
-0.00020519544,
0.051793873,
0.0037925208,
0.025279092,
0.0020063552,
-0.014604821,
-0.0023234943,
0.0038845404,
0.018522225,
0.003992992,
0.019376693,
0.020941025,
-0.029498845,
-0.004955911,
0.019705335,
-0.0033373528,
-0.03428386,
-0.022597378,
0.011528738,
0.004643702,
-0.01639263,
-0.021361686,
0.005931976,
-0.03806981,
0.021966387,
-0.013750353,
-0.034862272,
0.007197245,
0.017562592,
-0.016432066,
0.029472554,
-0.017694049,
0.012744711,
0.0051038,
-0.0097277835,
-0.0065235305,
-0.00074396183,
-0.032522347,
0.001201184,
0.0017220805,
0.013658334,
-0.010299619,
0.0066286954,
-0.007631052,
-0.004515532,
-0.0069606234,
-0.01787809,
-0.014381344,
0.040725235,
-0.014302471,
-0.0085315285,
0.008971908,
-0.0052188244,
-0.0026110553,
0.022663105,
-0.009405714,
-0.032890424,
-0.036728956,
0.0092151025,
0.015695909,
0.025095051,
0.003585477,
-0.0070000603,
-0.009405714,
-0.010575678,
-0.02588379,
-0.009458298,
0.008439509,
-0.053082146,
-0.015525016,
-0.01520952,
0.0007345134,
0.0077822264,
0.00035575425,
-0.009708065,
-0.012797293,
0.009353132,
-0.01929782,
0.027684746,
0.015170083,
0.022308173,
-0.013263964,
-0.010759717,
-0.031733606,
-0.010891174,
0.00990525,
-0.024477206,
-0.027842494,
-0.0046338425,
-0.018246166,
0.020520365,
-0.0018157433,
0.006829167,
-0.0023464991,
0.020218015,
-0.00060552167,
0.014433927,
-0.013171945,
-0.00402257,
0.010128725,
0.0034047242,
0.015893094,
-0.010128725,
0.01327711,
-0.015695909,
-0.008912752,
0.002448378,
-0.004706144,
-0.0056164805,
-0.017010475,
0.00475544,
-0.025542004,
-0.011180378,
-0.010109007,
0.0013408567,
-0.036466043,
0.028052824,
-0.0062441854,
-0.0014279466,
-0.02313635,
0.0003767051,
-0.001073014,
0.024674391,
0.0078611,
-0.006217894,
0.019192653,
0.015262104,
-0.023083767,
-0.0320491,
-0.00816345,
0.031470694,
0.03102374,
-0.023202078,
-0.004788304,
0.0033587143,
-0.035966508,
-0.004762013,
-0.024319459,
0.00872214,
0.009379423,
0.006888322,
-0.0010524739,
0.03686041,
-0.0046502748,
0.030971158,
-0.037491404,
-0.025318528,
0.009267685,
0.0097277835,
0.017759778,
-0.0029002598,
-0.028973019,
0.020033976,
0.00744044,
-0.007762508,
-0.0031598865,
0.002400725,
-0.010805727,
-0.0057052136,
-0.007834809,
0.020914733,
-0.00019050926,
-0.012146584,
-0.010174735,
-0.0246481,
0.0050610765,
-0.0038516764,
-0.016366338,
-0.021874366,
-0.0024368754,
0.02204526,
0.0135926055,
-0.00065974746,
-0.05371314,
-0.04127735,
0.0069080405,
-0.036676373,
0.020375762,
0.006980342,
-0.008597258,
0.016892165,
-0.0068423124,
0.016524086,
-0.008406646,
-0.010661124,
-0.0019044766,
0.0067634387,
0.00014224008,
-0.011909962,
-0.0024105841,
-0.008564393,
0.020796424,
-0.004768586,
0.01076629,
-0.007013206,
-0.024569226,
-0.035256643,
0.0072169635,
0.024845283,
-0.010358775,
-0.0028575363,
-0.005550752,
-0.013033915,
0.009359705,
-0.018338187,
0.007821663,
-0.027132628,
-0.012008554,
0.003365287,
-0.023714758,
0.012409496,
-0.011896816,
-0.036071673,
-0.020099703,
-0.00050446443,
0.17520526,
-0.005258261,
-0.0016777139,
0.019429276,
-0.010181309,
0.0022249017,
0.02936739,
-0.0026669244,
-0.018048981,
0.029656593,
0.013375702,
0.017970107,
-0.006894895,
-0.000099414,
0.0009596327,
-0.014263034,
-0.030865993,
-0.02976176,
0.009274258,
0.0018124569,
0.0077822264,
-0.018601099,
-0.0010171449,
-0.015419851,
0.029525137,
0.013073352,
-0.006608977,
-0.00678973,
0.02960401,
0.026028393,
-0.013434857,
0.005304271,
0.011903389,
0.009201957,
-0.030235002,
-0.014604821,
0.0013186734,
0.0049657705,
0.0039469823,
-0.00050939404,
0.003831958,
0.0029084757,
-0.011430145,
-0.022873437,
-0.008498665,
0.03601909,
0.003324207,
-0.020993607,
-0.015748492,
0.00042189332,
-0.018219875,
-0.00040648825,
0.021795493,
0.022544796,
0.005485024,
0.0019488431,
0.032496054,
-0.014486509,
0.027842494,
0.026659384,
-0.012304331,
-0.00085118104,
-0.013336265,
0.038990006,
-0.018482788,
0.029446263,
-0.0028328882,
-0.0015766568,
-0.0052155377,
0.0074535855,
-0.0034244426,
-0.026396472,
-0.017654613,
0.0161823,
-0.021374833,
-0.015104355,
0.03488856,
0.030918576,
0.0055014556,
0.009662055,
-0.008150305,
0.007959693,
-0.0048145954,
-0.00860383,
-0.038437888,
-0.017010475,
0.0135926055,
-0.00058374915,
-0.009057355,
0.014171014,
0.01011558,
-0.0161823,
-0.008334344,
0.00074971304,
0.0006905576,
-0.002242977,
-0.0015166798,
-0.012402924,
-0.0004448982,
-0.014223597,
-0.0042756237,
0.045668,
0.009274258,
0.00916252,
-0.030366458,
-0.018193584,
-0.03601909,
0.0144470725,
0.020730695,
-0.031286653,
-0.0011182021,
-0.012751283,
0.0077822264,
-0.018377623,
0.0037596568,
0.018088419,
0.001176536,
-0.0075916145,
-0.0103259105,
0.012245175,
0.00005065698,
-0.021098774,
0.0006486558,
0.006546535,
-0.016142862,
0.0015018908,
-0.007276119,
-0.012915604,
0.0049690567,
0.0022758413,
-0.00012591071,
-0.04729806,
-0.01146301,
0.016234882,
0.021203939,
0.018101564,
0.0039009727,
-0.00402257,
0.010352202,
0.0139343925,
0.017983254,
-0.011482728,
-0.008248897,
0.0053732856,
0.03864822,
-0.019481858,
0.017799214,
-0.0015528302,
-0.011804797,
0.0017450855,
-0.012001981,
-0.022978602,
-0.014591675,
-0.006300054,
0.011686485,
-0.00501178,
-0.0153015405,
-0.025134489,
0.005823524,
-0.000104703075,
-0.022084698,
-0.007657343,
0.015709056,
-0.004318347,
-0.012540953,
-0.006109442,
-0.16531974,
0.027921367,
0.02232132,
-0.017023621,
0.0023711473,
0.019521294,
0.027448123,
-0.007972838,
-0.017588884,
-0.0006404398,
0.01741799,
-0.016984183,
-0.0078019453,
-0.0056197667,
0.0034868845,
-0.010707134,
-0.030760828,
0.04388019,
0.006756866,
0.017772922,
0.011995409,
-0.02594952,
0.021690328,
-0.017838651,
0.02313635,
0.013152226,
-0.010930611,
0.0041375943,
0.00015076422,
0.0028509635,
-0.03625571,
-0.00709208,
0.041803177,
-0.0022018969,
0.0050873677,
-0.0047422945,
-0.020678112,
-0.009944687,
0.009839522,
0.025292236,
0.037728023,
0.02976176,
0.009412288,
0.004955911,
-0.020336326,
0.032127976,
-0.0036709236,
-0.019087488,
-0.011154086,
0.0010409714,
-0.0020655107,
-0.0039239773,
0.022071552,
-0.0049953484,
-0.019468712,
0.0063953605,
-0.028867854,
0.018469643,
0.0049066152,
-0.026514782,
0.012843303,
-0.020796424,
0.039121464,
0.0076376246,
-0.0011699632,
-0.024924159,
-0.011016057,
-0.033758037,
-0.0046535614,
0.02546313,
-0.02715892,
-0.016353192,
0.008498665,
-0.0034408746,
0.031155199,
0.0056329123,
-0.009497735,
-0.0027934513,
0.0030810125,
0.01539356,
0.0011264181,
0.019679043,
-0.014657403,
-0.0032929862,
-0.0131456535,
0.0058070924,
0.0007550535,
0.024214294,
0.0037892344,
-0.0032962726,
-0.011561602,
-0.034651943,
0.005573757,
-0.009524026,
-0.012508089,
-0.0007714855,
0.006730574,
-0.009234821,
0.005629626,
-0.026567364,
0.0009366278,
-0.0123963505,
-0.007867673,
-0.014775714,
0.011305261,
-0.0023744337,
-0.020139141,
-0.0016678547,
0.008748432,
0.004587833,
-0.01751001,
-0.00038738595,
0.00068603875,
0.037938356,
-0.012652691,
0.028631233,
0.002990636,
-0.007723071,
0.03057679,
-0.011653622,
0.05952352,
0.012028272,
-0.009885531,
0.027316667,
0.01369777,
-0.032943007,
-0.13408566,
-0.024293168,
0.031917647,
0.025857499,
-0.004683139,
0.005271407,
-0.009438579,
0.01271842,
0.021217084,
0.029840633,
-0.0056526307,
-0.017667757,
0.0025338246,
-0.012179447,
0.0317599,
0.0063329185,
0.032285724,
-0.0011839304,
-0.027027464,
0.05032156,
-0.026527928,
-0.02960401,
0.0063066273,
-0.003999565,
-0.0087024225,
-0.0017960249,
-0.021322249,
0.01760203,
0.0049756295,
0.028946728,
0.02594952,
0.0009448438,
0.016234882,
-0.010378493,
-0.01944242,
-0.009136229,
-0.009589754,
-0.012087428,
0.051583543,
-0.02376734,
-0.005225397,
0.029682884,
0.015682764,
-0.014867733,
0.013283682,
0.014368199,
-0.03381062,
0.009234821,
0.0025141062,
-0.017825505,
-0.000018588775,
0.0059944177,
-0.011936253,
0.009708065,
0.029630302,
-0.021848075,
0.002044149,
-0.020362617,
0.0067765843,
-0.0076704887,
-0.006687851,
0.00053075573,
-0.018745702,
0.016208591,
-0.0068751764,
-0.020283742,
-0.0041540265,
-0.010891174,
0.014986045,
0.0023169213,
0.003956842,
0.0028673955,
-0.009320268,
0.00012714311,
-0.036544915,
0.0031303086,
0.0004202501,
-0.020651821,
-0.012757856,
0.0065333894,
-0.017588884,
-0.0128038665,
-0.0020885156,
0.010358775,
0.01223203,
0.002210113,
0.0005217181,
0.0031155199,
-0.012146584,
-0.023925088,
-0.0042559053,
0.013894956,
0.017943816,
-0.0026997884,
-0.004768586,
0.024069691,
-0.004426799,
-0.012028272,
0.012731565,
0.0058695343,
-0.004640416,
-0.03885855,
-0.031076323,
0.009077073,
0.012166302,
-0.003831958,
0.006730574,
0.015183229,
0.023754194,
-0.011831088,
-0.007624479,
-0.009681773,
-0.0020145713,
0.015327832,
-0.02739554,
-0.021690328,
-0.044668928,
0.0015618679,
-0.0050216396,
-0.018075272,
0.03946325,
0.007887392,
-0.0017368695,
0.013191663,
-0.010477086,
0.041540265,
0.010437649,
-0.020888442,
0.00045434665,
-0.006178457,
-0.007539032,
-0.008840452,
0.033889495,
-0.040488612,
-0.0007616263,
-0.015117501,
-0.04004166,
-0.01772034,
-0.0025190357,
0.042959996,
-0.01581422,
0.021848075,
-0.012501516,
-0.02546313,
-0.0043512112,
-0.020678112,
-0.01669498,
-0.01183766,
-0.026409617,
0.014157868,
0.0054751644,
-0.009616045,
-0.0049756295,
-0.00016432066,
-0.009221676,
-0.017536301,
-0.030603081,
0.016195444,
-0.009392569,
-0.0025403975,
0.007972838,
-0.011482728,
0.037728023,
0.010174735,
-0.0032239715,
-0.024726974,
0.0021197365,
-0.014328762,
-0.016734416,
-0.0003454842,
0.010943756,
0.00060798647,
-0.024963595,
0.00505779,
0.019389838,
0.00972121,
0.01890345,
0.018640537,
-0.0032420468,
0.022518504,
-0.0062211803,
-0.00036294328,
0.018758846,
-0.006783157,
-0.027264085,
0.0030793692,
0.017970107,
0.023504429,
0.00886017,
0.022741979,
0.002583121,
0.022663105,
-0.008413218,
0.010641406,
-0.014591675,
-0.0004954268,
0.0038122395,
0.03985762,
0.017628321,
-0.019179508,
0.004055434,
0.035703596,
-0.025515713,
0.0033340664,
-0.019600168,
-0.04469522,
0.001965275,
-0.017260242,
-0.020599239,
-0.02679084,
-0.017549448,
0.008544674,
0.012652691,
0.023688467,
-0.001236513,
-0.0021575303,
-0.0046798526,
0.0064216517,
-0.036597498,
0.018601099,
-0.030839702,
0.024398332,
0.008354062,
0.005199106,
0.000035020843,
-0.0004699571,
0.019560732,
0.0075850417,
0.025187071,
-0.0018716124,
0.010884601,
0.014986045,
0.013868664,
-0.02092788,
-0.027106337,
-0.021992678,
-0.007893965,
-0.035572138,
-0.015630182,
0.010286474,
-0.00063222373,
0.07351049,
0.016865874,
-0.006862031,
-0.00064824504,
-0.0064709475,
0.023451846,
-0.004923047,
0.009655482,
-0.012692128,
-0.025594587,
0.03244347,
-0.015078064,
0.005977986,
-0.029235933,
-0.03018242,
0.0029511992,
0.017457427,
-0.0028115266,
0.0035328942,
-0.019955102,
0.0056657763,
-0.018640537,
-0.0090442095,
0.00769678,
0.0100695705,
-0.025003033,
0.049769443,
0.008426364,
-0.003657778,
-0.024700683,
0.009655482,
0.0043216334,
-0.03941067,
0.020704404,
0.025147634,
-0.01811471,
-0.008643267,
-0.024503497,
0.024398332,
0.013191663,
-0.020073412,
0.04146139,
-0.013388848,
0.027132628,
-0.0134874405,
-0.028236862,
-0.016261173,
-0.021506289,
-0.018456496
] |
Prolonged or intensive immunosuppressive therapy used after organ transplantation is complicated by an increased incidence of cancer. Striking differences in incidence are observed in heart and heart-lung transplant recipients when compared with renal transplant patients. The most significant increase was in the incidence of lymphomas in cardiac versus renal patients. Moreover, a two-fold greater increase of all neoplasms was found in cardiac recipients, with nearly a six-fold increase in visceral tumors. Several factors may account for these differences. In cardiac allograft recipients, intensive immunosuppression is frequently used to reverse acute rejection and the highest number of cardiac transplants was | [
-0.0072195693,
-0.002948046,
0.015458216,
-0.031287007,
-0.016331712,
0.01491559,
-0.027713617,
0.0012730198,
-0.033881024,
-0.0011994014,
0.010647376,
-0.009648151,
-0.0052872924,
-0.0004259943,
0.00807983,
0.01402886,
0.05203913,
-0.008589368,
-0.0119774705,
-0.010812811,
-0.031366415,
0.010634141,
-0.031287007,
-0.0037421323,
-0.017337555,
0.009112142,
0.01780077,
-0.035998587,
0.011626749,
-0.009204785,
0.015894964,
0.010812811,
-0.010316507,
0.012083349,
-0.01666258,
-0.002322703,
0.021480039,
-0.012440688,
0.016424354,
0.018687502,
0.028322417,
0.013373739,
-0.014002391,
0.01096501,
0.0018528684,
0.020950647,
0.007629847,
-0.034463353,
-0.019825691,
0.0153258685,
0.029381199,
-0.004317845,
0.017814007,
0.007517352,
-0.023584368,
-0.023822594,
0.0026039418,
0.021334456,
0.011606897,
-0.03348398,
-0.0030572328,
0.013420061,
-0.0032954589,
0.01840957,
-0.0023392464,
0.020328613,
-0.0120039405,
0.0069019347,
-0.005595001,
-0.016093485,
0.032398727,
0.03933375,
-0.02689306,
-0.00615417,
0.003391411,
0.0011596971,
-0.0028305873,
0.006935022,
-0.013009783,
-0.0002696585,
0.013082574,
-0.03411925,
-0.02226089,
0.038724948,
0.010759871,
0.01993157,
0.008311438,
0.006769587,
0.014187678,
-0.011196619,
0.008834212,
0.023941707,
0.008979795,
0.01322154,
0.006564448,
0.0051847226,
0.014227382,
0.042139523,
0.007881308,
-0.038486723,
-0.015167051,
-0.008926855,
-0.0055189007,
-0.018621327,
-0.032557543,
0.00891362,
0.005819992,
0.021255048,
0.030545859,
-0.00049506326,
-0.017033154,
0.051324453,
-0.00866216,
-0.017337555,
0.016093485,
-0.015762616,
0.03229285,
0.017655188,
0.0055321357,
-0.025013722,
0.021016821,
0.010296654,
0.031525232,
-0.023716716,
0.027925374,
-0.0058233007,
-0.031313475,
-0.002337592,
-0.009555507,
0.008907003,
0.014372964,
0.015167051,
-0.01243407,
0.027422452,
0.003682576,
0.0080401255,
0.005320379,
-0.023054976,
-0.010038576,
-0.038195558,
-0.016728755,
0.006369235,
0.022128543,
-0.0031614567,
-0.0009677929,
0.0037752194,
0.016530233,
0.01676846,
-0.012354662,
0.0024831744,
-0.0016071979,
-0.02406082,
0.001965364,
-0.020130092,
0.006620696,
0.00086770486,
-0.0072725085,
0.008291586,
-0.023637306,
-0.017694892,
-0.0045825406,
-0.021532977,
0.024974018,
0.00997902,
0.021082995,
0.0055685313,
0.010614289,
0.005247588,
-0.0095621245,
-0.0009231255,
-0.0035403022,
0.023332907,
-0.025516644,
0.023941707,
0.0013367122,
0.007351917,
-0.015842024,
-0.004221893,
-0.043568876,
-0.03231932,
-0.0062236525,
0.01937571,
0.009443011,
0.01760225,
-0.010296654,
0.00060549093,
0.012301723,
-0.017721362,
-0.016450824,
-0.006087996,
-0.028587112,
0.030598799,
-0.008271734,
-0.037242655,
-0.64246887,
-0.018316928,
0.027131287,
0.0015153816,
0.020169796,
0.029725304,
0.008807742,
0.014200913,
-0.03171052,
0.002256529,
0.0027462156,
0.019693345,
0.027184226,
-0.009012882,
0.012420836,
-0.03396043,
-0.012652444,
0.009231255,
0.02461668,
-0.011739245,
0.0033500523,
-0.00070061587,
-0.014690599,
0.02134769,
0.009072438,
0.01876691,
0.018886022,
-0.009840054,
0.002714783,
0.032557543,
-0.018608093,
-0.003191235,
-0.014306791,
-0.0119774705,
0.055427235,
0.014862652,
-0.01585526,
0.02666807,
-0.00072005444,
0.020275675,
-0.0030870112,
-0.010170924,
0.033616327,
-0.0064056306,
-0.025304887,
0.019362474,
0.029778242,
0.002499718,
0.006541287,
-0.0026932766,
0.020527136,
0.01099148,
-0.008165856,
-0.0035998586,
0.034939803,
-0.013274479,
0.032928117,
-0.007279126,
0.009350368,
-0.0000326475,
0.0131686,
0.030916432,
-0.012268635,
-0.01294361,
0.016397886,
-0.012798027,
-0.027422452,
0.008013655,
0.02345202,
0.013386974,
0.015656738,
0.018488979,
0.012414218,
-0.003669341,
0.01874044,
0.019772753,
-0.012698766,
-0.006471805,
-0.013029635,
0.010912071,
-0.015947903,
0.009105525,
-0.027581269,
0.003940654,
0.011335584,
-0.009965785,
-0.0012804645,
0.026496017,
-0.009529037,
0.0015567404,
-0.004403871,
0.013975922,
-0.0054064053,
-0.047327552,
-0.02552988,
0.020024214,
-0.021506509,
0.00607807,
-0.008582751,
-0.019547762,
-0.007980569,
-0.0065843,
-0.0053303055,
0.0011348819,
0.016530233,
-0.019084545,
-0.047909882,
0.013433296,
0.041186616,
-0.024960784,
0.00476121,
-0.007490882,
-0.004211967,
0.008827594,
0.0196007,
-0.006481731,
-0.0061409352,
0.0042384365,
0.0074445605,
-0.020950647,
0.016331712,
-0.00029612807,
0.008595986,
-0.0015236534,
0.012467157,
0.019733049,
-0.0028372048,
-0.008761421,
0.015100878,
-0.01402886,
0.017708128,
-0.022671169,
0.03406631,
-0.01555086,
0.034780987,
-0.014889121,
0.029090034,
0.014386199,
-0.016530233,
-0.0080467425,
-0.0074776476,
-0.0039571975,
0.018171346,
0.020672718,
-0.011917914,
0.008781273,
-0.013486235,
-0.000121491095,
-0.008099682,
-0.014624425,
0.005866314,
-0.024590211,
0.00055131107,
0.007801899,
0.019838927,
-0.00008323432,
0.022604994,
-0.0275548,
0.0049828924,
-0.021480039,
0.0141215045,
0.019058075,
-0.016516998,
0.018938962,
-0.02345202,
-0.023359377,
-0.010376063,
0.005214501,
-0.0057935226,
-0.03396043,
-0.016543468,
-0.026403375,
0.00091650814,
0.011739245,
-0.004655332,
-0.0065479046,
-0.023518194,
-0.016199363,
0.01602731,
0.025106367,
-0.004403871,
-0.027091583,
0.0032474827,
0.010098132,
0.010548115,
0.004049841,
0.010753254,
-0.0074776476,
-0.008933472,
0.032451667,
-0.021665325,
0.00747103,
-0.021162404,
0.008218795,
-0.00483731,
-0.014809713,
-0.006815909,
-0.0030009851,
0.016106721,
0.00587624,
0.008754803,
-0.022790281,
0.01762872,
-0.0051648705,
-0.0066967956,
-0.008801125,
0.0014822948,
-0.0012217351,
0.024801968,
0.0011778949,
-0.0049828924,
0.017522842,
0.008847446,
-0.009588594,
0.008172473,
0.01874044,
0.0064254827,
-0.016239068,
0.00010158723,
-0.013049487,
-0.0029927134,
0.014042095,
0.020831535,
-0.019680109,
-0.0006435409,
0.009787115,
0.010462089,
-0.013254627,
0.0043277713,
-0.019336006,
-0.007914395,
0.021056525,
0.012017175,
0.018647797,
-0.012453923,
0.011004715,
0.006435409,
0.00037408917,
0.026257792,
0.014928825,
-0.0025791267,
0.0052972184,
-0.011024567,
0.022234421,
0.018621327,
0.0014334915,
0.01638465,
0.007298978,
-0.0053964793,
0.025079897,
0.0013160328,
0.00074817834,
-0.006815909,
-0.011964235,
0.01291714,
-0.016305242,
0.016847868,
0.03223991,
0.04386004,
0.025926923,
0.016953746,
-0.0031035545,
-0.00038628996,
-0.009529037,
-0.021043291,
0.0026701158,
0.011223089,
-0.01203041,
0.011792184,
0.020831535,
-0.033245753,
-0.010733402,
0.027369512,
-0.05222442,
-0.0025923613,
0.023809358,
-0.004618936,
0.009429777,
0.012831113,
0.012407601,
0.003692502,
-0.03509862,
0.01433326,
0.025331357,
0.006269974,
-0.01175248,
-0.010263568,
0.011666453,
0.001980253,
0.017814007,
0.017112562,
-0.0116796885,
0.0038149236,
0.0070806043,
-0.00035320304,
-0.02023597,
0.021016821,
0.00777543,
0.0020910944,
-0.019587466,
0.0019091162,
-0.0064188656,
-0.031366415,
-0.014200913,
0.012553183,
0.015669974,
-0.009330516,
-0.03171052,
-0.015842024,
0.007815134,
-0.019918336,
-0.020315379,
-0.0021671944,
-0.03110172,
0.018105172,
-0.003910876,
-0.007073987,
0.017708128,
0.0054064053,
0.0052343532,
0.0028173525,
-0.029725304,
-0.00792763,
-0.03448982,
0.03470158,
-0.0116863055,
0.0010124602,
0.027925374,
0.0013102427,
-0.013975922,
0.011090741,
-0.028322417,
0.025013722,
0.0072328043,
-0.019428648,
-0.010495176,
0.018515449,
0.0051582535,
0.022115307,
0.037930865,
0.005250897,
0.001560049,
-0.018528683,
-0.010051811,
0.0034642022,
-0.01243407,
0.043198302,
0.044283554,
-0.001722175,
-0.0064949654,
0.02813713,
0.0072195693,
0.016834633,
0.0049398793,
-0.008457021,
0.026496017,
0.0054560355,
0.024246106,
0.002742907,
-0.0125995055,
0.026151914,
0.022088839,
0.007848221,
0.0024318898,
0.027210696,
0.021480039,
0.007782047,
0.002233368,
0.022141777,
-0.019071309,
-0.0032607175,
0.030148815,
-0.0017486445,
-0.014015626,
0.025926923,
-0.014545017,
-0.029778242,
-0.029937059,
0.015008234,
0.002600633,
-0.0005839844,
0.0033070392,
-0.022671169,
0.017536076,
0.023015272,
-0.010912071,
-0.01618613,
0.008225412,
-0.028348887,
0.010137837,
-0.026535721,
0.0015294435,
-0.021943256,
-0.02644308,
0.012831113,
-0.003487363,
0.0049266447,
0.013029635,
0.010508411,
-0.00433108,
0.016834633,
-0.007332065,
0.00092477986,
0.020725656,
0.01117015,
0.016252303,
-0.0080401255,
-0.036713265,
-0.0080401255,
-0.008622455,
-0.00039849078,
-0.00405315,
-0.0208183,
0.013148748,
-0.005595001,
-0.012692149,
-0.01289067,
0.014412669,
0.0063229133,
0.0033169652,
0.015352339,
0.004857162,
-0.000027994649,
-0.020262439,
-0.019587466,
-0.0059721917,
-0.029751772,
-0.00067249197,
-0.0045196754,
-0.029778242,
0.002914959,
-0.0081063,
0.012348045,
-0.015074408,
0.031154659,
-0.022247655,
0.002732981,
0.010276802,
0.026840122,
0.019177187,
0.00048720514,
-0.01218261,
0.030413512,
-0.00691517,
-0.011176767,
-0.0067894394,
0.019309536,
-0.008192325,
-0.020196265,
-0.026985705,
-0.0038777888,
-0.0043674754,
-0.027925374,
0.010878985,
-0.0025923613,
0.015961139,
-0.0057703615,
-0.017139032,
-0.027925374,
0.011289262,
0.016318476,
0.02752833,
0.028931217,
-0.03626328,
-0.02932826,
0.01243407,
-0.004969658,
-0.022750577,
0.021255048,
-0.028375356,
-0.021612387,
0.014571486,
0.017139032,
-0.01815811,
-0.0033070392,
-0.0058696223,
-0.020924179,
0.011335584,
-0.025397532,
-0.018475745,
-0.01433326,
-0.029513547,
0.022552056,
0.037930865,
0.040180776,
-0.015193521,
0.0042384365,
0.01666258,
-0.0055354442,
0.009529037,
0.0021076377,
0.04105427,
0.0004350932,
0.013300948,
0.022168247,
-0.0007928457,
-0.006190566,
-0.016371416,
0.0189919,
0.004522984,
-0.0089599425,
-0.015537625,
-0.014386199,
-0.046559937,
-0.022552056,
0.0071732476,
-0.0059953528,
0.012116436,
-0.01618613,
-0.014902356,
0.004575923,
0.007087222,
-0.00143101,
-0.003907567,
0.005819992,
-0.015100878,
-0.028348887,
0.014161209,
-0.017059624,
0.00802689,
-0.027448922,
-0.0038380846,
-0.018700736,
-0.011461315,
0.00026159358,
0.0196007,
0.0202095,
-0.024351984,
0.027607739,
0.0055552963,
-0.043595348,
-0.018886022,
-0.020103622,
-0.03268989,
0.008880533,
0.0017039772,
-0.023412315,
-0.029010626,
-0.012063497,
0.0068688476,
-0.0066140783,
0.015947903,
-0.013148748,
-0.0038480107,
0.0034278065,
-0.02406082,
0.006491657,
-0.04454825,
0.0027462156,
0.02193002,
-0.02813713,
-0.030281164,
-0.025900453,
0.0058398442,
-0.00046859373,
0.025013722,
0.020196265,
-0.014875886,
0.007457795,
0.0057902136,
0.023954941,
-0.023822594,
-0.033642795,
0.010713549,
0.0068291435,
0.0029199221,
-0.024404924,
-0.03861907,
-0.018647797,
-0.0014988382,
0.0029463917,
-0.0020431182,
0.00607807,
-0.023028508,
-0.020262439,
-0.0024567049,
-0.022062369,
-0.00077051204,
-0.0018644488,
-0.016014077,
-0.015749382,
-0.024431393,
-0.01435973,
0.008715099,
-0.00896656,
0.024576975,
0.013453148,
-0.0014070219,
0.0081063,
-0.0076166126,
0.011944383,
0.010614289,
-0.023319673,
0.041345436,
0.00997902,
0.0006059045,
0.010601054,
0.0033699044,
-0.00002858918,
-0.015762616,
0.0010008798,
0.008873916,
-0.029487077,
0.011845123,
0.020937413,
0.035892706,
-0.002565892,
0.014822947,
-0.02813713,
-0.004569306,
-0.004235128,
-0.014981764,
0.012625975,
-0.027898904,
-0.006640548,
0.000049578706,
0.00866216,
-0.009608446,
-0.0049928185,
-0.008238647,
0.0038149236,
0.03655445,
-0.014346495,
0.008556281,
0.019481588,
0.012480392,
-0.025384298,
0.006954874,
-0.013248009,
-0.02547694,
0.0060946136,
-0.017761067,
-0.05037155,
-0.020275675,
-0.011951001,
0.003573389,
-0.020646248,
-0.003606476,
0.018224284,
-0.00028682238,
0.005310453,
-0.010018724,
-0.02309468,
0.046004076,
-0.016516998,
-0.0019521292,
0.017655188,
-0.00995255,
0.00777543,
-0.020063918,
0.021135934,
0.003735515,
-0.01727138,
-0.01068708,
-0.01058782,
-0.0012854275,
-0.0064387177,
-0.014730304,
-0.021188874,
-0.008404082,
-0.014783243,
0.00881436,
0.025635758,
0.0016733718,
0.014161209,
0.0031019002,
0.010812811,
0.009184933,
-0.021996194,
0.014081799,
0.0007523142,
-0.014545017,
-0.0059655746,
0.0009355331,
-0.005906018,
0.051430333,
0.0030042937,
0.0048340014,
-0.0015757653,
0.0052641314,
-0.058444764,
0.004747975,
0.020725656,
0.031631112,
-0.006435409,
0.0122884875,
0.004314536,
0.020460961,
-0.01056135,
0.032584015,
-0.004575923,
-0.012970079,
0.019336006,
-0.0070607523,
0.026866592,
0.0014343186,
-0.038989644,
-0.023213794,
0.009985637,
-0.0042384365,
0.004857162,
0.031313475,
-0.009204785,
-0.0010629178,
-0.03692502,
0.005181414,
-0.038539663,
-0.00010360347,
-0.007762195,
-0.027925374,
-0.0024815202,
0.028190069,
0.0017469903,
-0.009628299,
0.002676733,
0.015114112,
0.013949452,
-0.010892219,
-0.0027776482,
-0.011242941,
0.008390847,
-0.03168405,
0.0026403375,
0.023902003,
0.0015873457,
0.0074644126,
-0.0075107343,
0.011798801,
0.0000068241807,
-0.012678914,
-0.000009486645,
-0.019111015,
0.018581623,
0.006670326,
-0.027607739,
0.030042937,
0.008867299,
-0.01007828,
-0.023266733,
0.018250754,
-0.0056413226,
-0.019997744,
0.03745441,
0.0074776476,
-0.023081446,
0.0076166126,
0.016040547,
-0.018912492,
-0.030916432,
-0.02613868,
0.012262018,
-0.0011026221,
-0.012705383,
-0.008132769,
-0.010475324,
-0.011792184,
-0.011434845,
-0.028243009,
-0.010111367,
0.015193521,
0.19248655,
-0.027104817,
-0.014147974,
-0.015392043,
-0.02489461,
0.006954874,
0.025093133,
-0.019190423,
-0.014412669,
0.023319673,
0.017946353,
-0.0016717174,
-0.0077886647,
0.0012142905,
0.0077158734,
-0.006759661,
-0.022327064,
-0.00790116,
0.005257514,
0.0023541355,
-0.009482716,
0.002905033,
0.026959235,
0.0072526564,
0.026946,
-0.0023905311,
-0.015881728,
0.01058782,
0.032213442,
-0.01696698,
-0.0035998586,
-0.013175217,
-0.009343751,
-0.0016287044,
0.015683208,
-0.016318476,
-0.015749382,
-0.03358986,
-0.003029109,
-0.003158148,
-0.026681304,
0.0016874337,
-0.0038083063,
0.0018561771,
0.003897641,
0.02805772,
0.0074644126,
-0.007801899,
-0.014677364,
-0.028401826,
-0.030122345,
-0.007126926,
0.012189227,
0.008457021,
0.027131287,
0.018661031,
0.030784085,
-0.009449629,
0.012050262,
0.013949452,
0.008887151,
0.010369445,
-0.028401826,
0.031366415,
-0.005810066,
0.024762264,
-0.01289067,
-0.006895317,
0.009443011,
-0.015233225,
0.0013168601,
-0.016014077,
-0.01494206,
0.003980358,
-0.00792763,
-0.0086555425,
0.0012647482,
0.0057306574,
-0.0129105225,
0.008986412,
0.0019984508,
-0.01083928,
-0.016424354,
0.006097922,
-0.004969658,
-0.018025763,
0.01785371,
0.009932698,
-0.012850965,
0.03287518,
-0.0033616326,
-0.016556703,
-0.019388944,
-0.01129588,
0.02056684,
-0.00009295361,
0.023954941,
-0.00040262664,
-0.018872788,
-0.007332065,
-0.021519743,
0.07787341,
0.004466736,
0.015947903,
-0.016040547,
0.0037421323,
0.012936992,
0.017469902,
0.005945722,
0.00863569,
0.03290165,
-0.02259176,
-0.0043906365,
-0.024193168,
0.006875465,
0.030969372,
0.0020249204,
-0.0052178097,
0.018859554,
-0.0045296014,
0.002623794,
-0.021294752,
0.01466413,
0.018912492,
-0.01463766,
-0.0116929235,
-0.033748675,
0.0046057017,
0.0020249204,
-0.014505313,
0.006058218,
-0.022353534,
-0.01577585,
0.01782724,
0.016516998,
-0.0072328043,
0.009906229,
-0.009363603,
-0.016530233,
0.022843221,
0.006329531,
-0.018687502,
0.01615966,
-0.011322349,
0.021215344,
-0.00949595,
0.0040961625,
0.010111367,
-0.019852161,
-0.009079055,
-0.016000843,
-0.0008114571,
-0.01466413,
-0.008701864,
0.01721844,
-0.0027296722,
-0.021691795,
-0.023584368,
-0.0003083289,
0.021321222,
-0.033086937,
0.015590564,
0.0008118707,
-0.0016535196,
-0.0064089396,
-0.006554522,
-0.16612288,
-0.001922351,
0.033060465,
-0.011004715,
0.03107525,
-0.008986412,
0.009714324,
0.0021738117,
-0.017191973,
0.031260535,
0.04637465,
0.012487009,
-0.024484333,
-0.03578683,
-0.00019200762,
-0.00838423,
-0.010931924,
0.05082153,
0.03568095,
-0.0015617034,
0.021241812,
-0.031154659,
0.011997323,
-0.032557543,
-0.005906018,
-0.003573389,
0.008059978,
-0.011395141,
-0.0032640263,
-0.021903552,
-0.034807455,
0.014399434,
0.0059887352,
-0.010984862,
-0.0046222447,
0.018025763,
0.013843574,
-0.00270982,
0.01375093,
0.034410413,
0.037269123,
0.015656738,
0.0030655046,
0.013565644,
-0.019772753,
0.020858005,
0.0022631465,
-0.01815811,
0.013989156,
0.021228578,
0.0266416,
0.006835761,
-0.0070408997,
0.0033285457,
-0.008999647,
0.0030721219,
0.024246106,
-0.0002824797,
-0.00062286155,
0.013473,
-0.0051350924,
-0.018541919,
0.011176767,
0.011342201,
0.007385004,
-0.038539663,
-0.0032574087,
-0.0026171766,
-0.023941707,
0.013631818,
-0.03560154,
0.0064188656,
0.019547762,
0.0006121083,
0.036580916,
0.005992044,
-0.0125598,
-0.00092477986,
0.010508411,
0.0023210486,
0.0024666311,
-0.0010472015,
-0.0054394924,
-0.018886022,
-0.015100878,
0.021493273,
0.020580074,
0.005856388,
-0.002852094,
-0.020977117,
0.016689051,
-0.042483624,
-0.015961139,
0.001927314,
-0.019269831,
0.028454764,
0.0011133754,
0.0009520766,
0.014452374,
-0.0029497002,
0.033192813,
-0.020672718,
-0.0211227,
-0.008887151,
0.011190002,
-0.03287518,
-0.008562899,
-0.0037222803,
0.029672364,
-0.0056876442,
-0.008099682,
0.04158366,
0.0013251317,
0.0134994695,
-0.009429777,
0.002914959,
0.0131686,
-0.009317281,
0.0023210486,
-0.029381199,
0.049630404,
0.017681658,
-0.003134987,
0.0049961274,
0.030598799,
-0.0020728966,
-0.12906551,
-0.02766068,
0.022777047,
-0.00014186023,
0.0065082004,
0.023994645,
0.006488348,
-0.0053402316,
-0.030413512,
0.03753382,
-0.011984088,
-0.011580427,
-0.021890316,
0.004678493,
0.040127836,
0.00008313092,
0.012930375,
-0.033192813,
-0.006167405,
0.044362962,
-0.01352594,
-0.009595212,
-0.012076732,
-0.014306791,
-0.00868863,
-0.0031068632,
-0.024206402,
0.020580074,
0.019097779,
0.01788018,
0.02453727,
0.019455118,
-0.000008213573,
-0.0034708194,
-0.015789086,
0.015114112,
-0.021850612,
-0.01375093,
0.038592603,
-0.015074408,
-0.011864975,
0.020037448,
-0.0092577245,
-0.00033438485,
0.005935796,
-0.011236323,
-0.030016469,
0.004536219,
0.023968177,
-0.027395982,
-0.015511155,
-0.058444764,
-0.0132016875,
0.024232872,
0.026522487,
-0.019150719,
0.013989156,
0.022035899,
-0.024749028,
0.0011861667,
0.0011969199,
-0.00031205115,
-0.0189919,
0.018502215,
0.0062236525,
-0.024166698,
-0.0062137265,
-0.016199363,
0.008119534,
-0.03464864,
-0.016344946,
-0.031895805,
-0.047618717,
-0.005313762,
-0.027065113,
-0.009171698,
-0.014518548,
-0.018687502,
0.026032802,
-0.021996194,
-0.01904484,
0.000982682,
0.028984156,
0.0067960564,
0.018515449,
0.023319673,
0.014492078,
-0.009628299,
-0.004073002,
0.00433108,
-0.009118759,
0.013148748,
-0.00691517,
-0.024881376,
0.0037288975,
-0.0008428897,
-0.022935864,
-0.021810908,
0.00860922,
0.014386199,
-0.013989156,
-0.0029000698,
-0.042324807,
0.01699345,
-0.0036792671,
0.001211809,
0.009059203,
-0.018475745,
0.010455471,
-0.015206756,
0.030784085,
-0.01671552,
-0.03237226,
0.0066868695,
-0.021797674,
0.0010141146,
-0.009158464,
0.011044419,
0.0028785635,
0.0051648705,
0.0006629795,
0.017893415,
-0.015934668,
0.0014012317,
-0.00919155,
0.021863848,
0.022141777,
-0.012175992,
-0.016464058,
0.019190423,
-0.004767827,
-0.01491559,
0.018594857,
-0.027687147,
-0.021109466,
-0.0063857785,
-0.022088839,
-0.028295947,
0.0012697112,
0.025543114,
0.0043906365,
0.030678207,
-0.027740087,
-0.0379838,
0.022697639,
0.016569937,
-0.019865396,
-0.0051781056,
-0.025331357,
0.039360218,
-0.006954874,
-0.013367122,
0.020302143,
0.0043244623,
0.005257514,
-0.021890316,
-0.010581202,
0.014902356,
0.018343396,
-0.00777543,
-0.026932765,
-0.005121858,
0.004466736,
-0.004122632,
-0.010117985,
-0.018290458,
0.015352339,
-0.020725656,
-0.03996902,
-0.0026734243,
0.008695247,
0.0026039418,
-0.014068565,
0.021016821,
-0.006716648,
0.003163111,
-0.0069019347,
0.02114917,
0.009806967,
0.0205139,
-0.0055685313,
0.01058782,
0.022181481,
-0.0019967966,
-0.0061045396,
0.011924531,
0.0058927834,
0.020725656,
-0.008543047,
0.04219246,
0.014650895,
0.01433326,
0.004436958,
0.007490882,
-0.011772332,
0.009290812,
0.012381132,
0.03811615,
0.007146778,
-0.007431326,
0.00058646593,
0.029513547,
0.01874044,
-0.008152621,
0.0053369226,
0.0034377326,
-0.009820202,
0.0043112277,
-0.044415902,
-0.027184226,
-0.019031605,
0.01660964,
0.031260535,
0.0011183384,
0.019336006,
0.0141215045,
-0.021003587,
0.009529037,
-0.0024864832,
-0.024709323,
-0.015074408,
0.03160464,
0.00747103,
0.0083511425,
-0.020196265,
0.006815909,
0.004231819,
0.004698345,
0.009165081,
-0.025159305,
0.012566418,
0.009813585,
0.023002038,
-0.012546566,
-0.030863494,
-0.022419708,
-0.009912846,
-0.040127836,
0.012414218,
-0.0010347939,
-0.0033302,
0.047089327,
-0.007126926,
-0.023994645,
0.016649347,
-0.0062137265,
0.015034704,
0.0050027445,
0.023068212,
-0.01205688,
-0.016093485,
0.009965785,
-0.009118759,
0.029195912,
-0.041821886,
-0.016781693,
0.030360572,
0.0031945435,
0.0049034837,
0.003153185,
-0.01129588,
0.019137483,
-0.009985637,
0.00995255,
0.008265116,
-0.013896513,
-0.01435973,
0.007087222,
-0.0122951055,
0.004655332,
0.0019984508,
0.0072195693,
0.020222735,
-0.039571974,
-0.016199363,
0.0027313265,
0.006693487,
0.00037119407,
-0.02403435,
-0.005022597,
-0.0047777537,
-0.023306437,
0.028243009,
-0.019428648,
-0.032557543,
-0.002299542,
-0.025648993,
-0.040683694,
-0.004251671,
-0.0183831
] |
The invasion of cancer cells into the surrounding tissue is a prerequisite and initial step in metastasis, which is the leading cause of death from cancer. Invasive cell migration requires the formation of various structures, such as invadopodia and pseudopodia, which require actin assembly that is regulated by specialized actin nucleation factors. There is a large variety of different actin nucleators in human cells, such as formins, spire and Arp2/3-regulating proteins, and the list is likely to grow. Studies of the mechanisms of various actin nucleation factors that are involved in cancer cell function may ultimately provide | [
0.0042132325,
-0.013259682,
0.00026228538,
-0.01099307,
-0.01765291,
0.027146017,
-0.039919045,
0.008106473,
-0.0111530665,
-0.005049879,
0.015919618,
0.0032315892,
0.021426152,
0.01694626,
-0.010826407,
0.008926453,
0.031092588,
-0.005676531,
-0.017412916,
0.014279658,
-0.02547939,
0.012526367,
0.0026399367,
-0.008379799,
0.00097164337,
0.015972951,
-0.00066331745,
-0.033865854,
0.012206375,
-0.029119302,
0.011046402,
-0.010233088,
-0.0034799166,
-0.017132923,
-0.02282612,
0.020852834,
0.011619722,
-0.019799525,
-0.004469893,
-0.012986355,
0.014452987,
-0.020372845,
-0.0000125452725,
-0.017972903,
-0.008679792,
-0.0078064795,
-0.01450632,
0.0037432436,
-0.02265279,
0.0017432916,
0.0121530425,
0.0059598573,
-0.016639601,
-0.016226279,
-0.005106544,
-0.0320259,
0.0041599004,
0.0088997865,
0.02473274,
-0.0036865782,
-0.014039664,
0.007533153,
-0.012466368,
0.024519412,
-0.013679672,
0.038132418,
-0.011486392,
-0.0053065396,
-0.0025366058,
0.0004529058,
0.03277255,
0.042398985,
-0.0030432604,
0.0007137329,
0.01223304,
-0.03738577,
-0.025119398,
-0.0024749406,
-0.029839285,
0.024226086,
-0.007946476,
-0.026039377,
0.016652934,
0.04551891,
0.0023332774,
0.007853145,
-0.001964953,
-0.0004358229,
0.0049398816,
-0.0025782716,
0.011246397,
0.02583938,
0.020186182,
0.014172994,
-0.006886502,
0.018079568,
-0.016706266,
0.0037799093,
0.005103211,
-0.023186112,
0.013559675,
0.016466273,
-0.020972831,
-0.017039591,
-0.016226279,
0.00094164413,
0.0076731495,
-0.00027436842,
0.027732668,
-0.0022966117,
-0.013199684,
0.034132514,
0.0010916406,
-0.03383919,
0.021226158,
-0.011646388,
0.032745883,
0.010746409,
-0.015639625,
-0.0115863895,
0.0032932544,
0.017186254,
0.023372773,
-0.011879715,
0.03034594,
0.005196542,
-0.0090664495,
0.013519676,
0.0013374679,
-0.024106089,
0.027466008,
0.0031132586,
0.009773099,
0.0060931873,
-0.0031799239,
-0.0049898806,
-0.009706434,
-0.02517273,
-0.025239395,
-0.027626004,
0.0017816239,
0.038239084,
0.008279801,
0.00765315,
-0.009626436,
0.01999952,
0.02459941,
-0.009666435,
0.011533057,
0.01862622,
0.017692909,
-0.009839764,
0.008533129,
-0.028879307,
-0.013799669,
0.025146063,
-0.009573104,
0.030719263,
-0.006999832,
-0.0121863745,
0.007966476,
0.02879931,
0.0012399703,
0.001100807,
0.021826144,
0.032212563,
0.008693125,
-0.0051465435,
-0.018146232,
-0.008193137,
0.014572985,
0.0048332177,
-0.029972615,
0.02879931,
-0.005586533,
0.0064665116,
-0.011713053,
0.038825735,
-0.029225966,
-0.012326371,
-0.0052798735,
0.0061998516,
0.01870622,
-0.0029349297,
-0.017186254,
0.0019516199,
0.020946166,
-0.012073044,
-0.01013309,
-0.00529654,
0.002754934,
0.008439798,
0.0005337372,
0.008679792,
-0.639558,
-0.032399222,
0.039439056,
-0.022026138,
-0.011593056,
0.023852762,
0.018586222,
-0.014252991,
-0.005683197,
-0.006086521,
-0.019266205,
0.025199397,
0.026039377,
-0.020599507,
-0.023719432,
-0.024319418,
-0.015852954,
-0.012666363,
0.013786336,
-0.0025349392,
-0.0077264817,
0.0063831806,
-0.0028465984,
0.007706482,
-0.016052948,
0.021426152,
0.024492746,
-0.007139829,
0.00018155815,
0.032905877,
-0.027172683,
0.016239611,
-0.009039784,
-0.007973142,
0.043572288,
0.0019149542,
-0.009059783,
0.036265798,
0.018346228,
0.032159228,
-0.018692885,
-0.0052932063,
0.006906501,
0.00654651,
-0.011866382,
0.00075831515,
0.0037465768,
-0.008406465,
0.014452987,
-0.0040832353,
0.015999617,
0.017546246,
-0.042718977,
-0.0047132205,
0.019119542,
-0.005193209,
0.02026618,
-0.025052734,
-0.0018582888,
0.0066098417,
0.00049082155,
0.01459965,
-0.026292704,
-0.036692455,
-0.026346035,
0.018172897,
-0.029492626,
0.02402609,
-0.012566365,
-0.0051632095,
0.017399583,
0.024932737,
0.00019187041,
0.0033165873,
0.013479677,
0.05021213,
-0.011746385,
0.001964953,
-0.00019384953,
-0.0015999617,
0.013133018,
0.0027865998,
-0.034425844,
-0.005933191,
0.020452844,
0.016746266,
-0.028212657,
0.017546246,
0.0058065276,
0.017039591,
0.0036465793,
0.010546414,
-0.011879715,
-0.04751886,
-0.020506175,
0.02597271,
0.013126352,
-0.0047398866,
-0.0049865474,
-0.0079998085,
-0.015959617,
-0.0051365434,
0.009479773,
0.00035790808,
0.016252944,
-0.014119661,
-0.03255922,
0.0046998872,
0.027546007,
-0.043145634,
-0.00049290486,
-0.009339776,
0.008506463,
-0.02725268,
-0.008986452,
-0.018399559,
-0.0022432795,
0.022159468,
-0.0040199035,
-0.010746409,
0.018252896,
0.0016999593,
-0.01870622,
-0.007139829,
0.03583914,
0.0022732788,
0.010613079,
-0.034425844,
-0.012993022,
-0.005876526,
-0.006406513,
-0.010093091,
0.0037832428,
-0.027332678,
0.021092828,
0.003169924,
-0.00074414886,
0.004243232,
0.013959666,
-0.026212705,
-0.020506175,
-0.012506367,
0.027759334,
-0.010206422,
-0.0013733004,
-0.022866119,
-0.02211947,
-0.005309873,
0.0069198343,
0.01711959,
-0.012059711,
0.01694626,
0.018066233,
0.017999569,
0.037759095,
-0.007326491,
-0.0047098873,
-0.022026138,
-0.0023816095,
-0.020279514,
-0.013946333,
0.0062831827,
-0.011359728,
0.014879644,
0.000028176408,
-0.008306468,
-0.0029215966,
-0.0048865494,
-0.0061965184,
-0.039519053,
-0.0031315917,
-0.004946548,
-0.01364634,
0.013919666,
-0.011566389,
-0.0012541367,
-0.015866287,
0.002259946,
-0.012699695,
0.012093044,
0.0051365434,
-0.030905927,
0.012459702,
-0.004943215,
0.010279754,
0.032799214,
0.034345843,
-0.011613055,
-0.0039599054,
0.027972663,
-0.013606341,
0.020866167,
0.021066163,
-0.00060165225,
0.026226038,
-0.04133234,
0.004693221,
0.028319322,
-0.0016649601,
0.020332847,
0.016599603,
-0.014346323,
0.005496535,
-0.012439702,
0.035679147,
-0.0029682622,
-0.009126448,
-0.015959617,
0.02242613,
-0.0081331385,
0.0120197125,
0.008446464,
-0.009386442,
0.014239659,
0.018919546,
0.0020866166,
-0.006386514,
-0.011733052,
-0.019759526,
0.0008941452,
-0.02265279,
-0.0071731615,
0.02933263,
-0.019412868,
-0.017572911,
0.0026816025,
0.022239467,
0.019132875,
0.00065165106,
-0.008906453,
-0.0059631905,
0.022892784,
-0.0061965184,
0.026799358,
0.00738649,
0.0027316012,
0.0075598187,
0.0008403965,
0.021732813,
-0.011193065,
0.005796528,
0.006286516,
-0.006459845,
-0.009786433,
0.012279706,
0.0005108211,
0.024639409,
0.006133186,
-0.007206494,
0.010359752,
-0.00039228227,
0.008533129,
-0.0013016355,
0.015359632,
-0.0067831706,
-0.036532458,
0.010466416,
0.015052972,
0.04485226,
0.009479773,
0.01999952,
-0.02534606,
0.015919618,
-0.012033045,
-0.014879644,
-0.021252824,
0.018279562,
0.007206494,
0.009099782,
-0.0045265583,
-0.029892618,
0.0006004023,
0.028132658,
-0.03637246,
-0.0016266278,
0.012613031,
0.017906237,
-0.005193209,
0.004879883,
-0.001486631,
0.0016899596,
-0.03986571,
0.016052948,
0.014279658,
-0.006666507,
-0.027892666,
-0.030319273,
0.02415942,
-0.0076731495,
0.015199636,
-0.011566389,
0.015892953,
-0.0049798805,
-0.014119661,
-0.015292967,
-0.005796528,
0.007006499,
-0.014692982,
0.033199206,
0.020492842,
0.013559675,
-0.006316515,
-0.0024932737,
-0.014212993,
0.057971943,
0.005156543,
0.012699695,
-0.0050465455,
-0.019666195,
-0.033679195,
-0.03658579,
0.011446392,
-0.012779694,
-0.008393132,
-0.0044598933,
-0.021746146,
0.016359609,
-0.007546486,
0.040879022,
-0.0011841384,
-0.0012566366,
-0.02587938,
0.008126472,
-0.00094164413,
0.025546055,
0.036559124,
0.0026582696,
0.007166495,
-0.006796504,
-0.01194638,
-0.0024832739,
-0.019386202,
0.026226038,
-0.029385963,
-0.0010541414,
0.010033093,
0.019919522,
-0.0027382676,
0.020772835,
0.042318985,
-0.0020916166,
-0.008006475,
-0.024706075,
-0.0055698664,
0.0024932737,
-0.020986164,
0.056265317,
0.024612743,
0.027212681,
-0.00020145351,
-0.0043965615,
0.0075531523,
0.0069265007,
-0.0027716001,
-0.010319753,
0.005789861,
0.003366586,
0.014652982,
-0.009346442,
-0.027332678,
-0.0046432223,
0.027492674,
-0.017839573,
-0.0028632646,
-0.0016132947,
0.002986595,
0.0018049567,
-0.012726362,
0.016799597,
-0.018919546,
0.00944644,
-0.00034790832,
0.017279586,
-0.00738649,
0.030159278,
-0.024852738,
-0.0016174612,
-0.031839237,
0.0025116066,
0.0017999569,
0.014479653,
-0.0063965134,
0.0058331937,
-0.016706266,
-0.012773028,
-0.015839621,
0.008953119,
-0.026639361,
-0.007313158,
-0.03671912,
-0.013153018,
-0.0037165775,
-0.024132755,
-0.012739695,
0.026906023,
-0.048558835,
-0.01681293,
0.0030515937,
0.010626412,
0.016626269,
0.013679672,
-0.02574605,
-0.017319584,
0.022839453,
0.0059898566,
-0.0047398866,
-0.0154396305,
-0.03418585,
0.0027566007,
-0.009153114,
0.0011424726,
-0.01127973,
0.013173018,
-0.003773243,
-0.005453203,
-0.0063465144,
-0.0153063,
-0.015772955,
-0.016439606,
0.016692933,
0.0002270779,
0.0077864802,
-0.010699743,
0.0036365795,
-0.008439798,
-0.032585885,
-0.023399439,
-0.026732692,
-0.01685293,
-0.0070798304,
0.021292822,
0.007993142,
-0.021812811,
-0.017732909,
0.006773171,
-0.022466129,
0.0069398335,
-0.01681293,
0.022852786,
0.033519197,
0.007179828,
0.015666291,
-0.012953023,
0.018386226,
-0.0003160341,
0.0078664785,
0.01973286,
0.0031899235,
-0.016692933,
-0.0023916094,
0.0023999426,
-0.000265202,
-0.017772907,
0.0010816407,
-0.0022966117,
0.017452914,
0.009186447,
-0.028239323,
0.004089902,
-0.0111264,
0.011266396,
0.0013699671,
-0.008346466,
-0.015586293,
-0.016866263,
0.0032165896,
-0.006316515,
-0.03562581,
0.02986595,
-0.032479223,
-0.0036432461,
0.016639601,
0.0050432123,
-0.00038019923,
-0.01937287,
0.0012733028,
-0.018786216,
-0.013299681,
-0.023146112,
-0.020332847,
-0.01870622,
-0.008373133,
0.04365229,
0.031119255,
0.028985972,
0.009559771,
0.037705764,
0.0043732286,
0.018426225,
-0.0036465793,
0.00820647,
0.010519748,
-0.013813002,
0.027106017,
0.014852977,
0.02547939,
0.018452892,
-0.022172801,
0.019786192,
0.011806384,
-0.02017285,
-0.021226158,
-0.002379943,
-0.04698554,
-0.02574605,
0.03154591,
-0.010526414,
-0.0010624746,
-0.040639028,
-0.0019049543,
0.00011843466,
-0.0040732357,
-0.003929906,
-0.017319584,
0.021066163,
0.0046398886,
0.013153018,
-0.025012733,
-0.006063188,
-0.0333592,
-0.013399679,
-0.0011458059,
-0.0019749526,
-0.0061065205,
-0.022026138,
0.013473011,
0.011613055,
-0.0065165106,
-0.015839621,
0.0124863675,
-0.014586317,
-0.017452914,
-0.0044098943,
-0.037305772,
-0.0030732597,
-0.016119614,
-0.029439295,
-0.025679385,
0.0057931948,
0.016319608,
-0.0021049497,
0.015466296,
-0.017012926,
-0.021506151,
0.032372557,
-0.0055698664,
-0.00820647,
-0.017279586,
0.022412796,
-0.0030432604,
-0.00862646,
-0.015652958,
-0.0036232464,
-0.016746266,
0.0076198173,
0.031039257,
0.0093331095,
0.0077131484,
-0.018919546,
-0.012006379,
0.013019688,
-0.012459702,
-0.03746577,
0.030639267,
-0.004676555,
0.024039425,
-0.0071598287,
-0.012913024,
-0.022746122,
-0.0038765739,
-0.00003351482,
0.0052098753,
0.0039332393,
-0.005683197,
-0.016732933,
-0.009206446,
0.0010524748,
0.023466105,
0.0051598763,
-0.03047927,
-0.0035732477,
-0.015052972,
0.0124197025,
0.0080664735,
-0.017346252,
0.013986331,
-0.00889312,
0.0061998516,
0.027652672,
0.038985733,
-0.010006427,
-0.011926381,
-0.010826407,
0.047918852,
0.0020066185,
-0.005103211,
-0.015479629,
0.0092664445,
0.021252824,
-0.023439439,
-0.00045457244,
0.02959929,
-0.029439295,
-0.0052932063,
0.022332799,
-0.016079614,
0.00640318,
-0.009593103,
-0.012579699,
-0.007139829,
-0.005509868,
-0.0047832187,
0.000847063,
-0.029652623,
-0.029892618,
0.01003976,
0.019146208,
0.010419751,
0.011159733,
0.0020082851,
0.0027699335,
0.04338563,
-0.021959474,
0.027679337,
0.005969857,
-0.0030265942,
-0.01499964,
0.019652862,
0.0057565286,
-0.030105945,
0.014172994,
-0.010599746,
-0.027266013,
-0.012926357,
-0.013679672,
0.015906285,
0.012059711,
-0.0065165106,
0.0046098894,
0.016066281,
0.0124197025,
0.023412772,
-0.012759694,
0.010786409,
-0.02826599,
0.013906334,
0.025772715,
-0.009606437,
-0.022306133,
-0.009233112,
-0.009306444,
0.013166351,
-0.017812906,
-0.013566341,
-0.01923954,
-0.0070131654,
0.005379871,
-0.0051865424,
0.010886406,
-0.015012974,
-0.018252896,
0.0064365123,
0.009053117,
-0.009166447,
-0.0021266157,
0.00076123176,
-0.008713124,
-0.0021482818,
-0.031359248,
0.0021516152,
0.007299825,
-0.027732668,
-0.014546318,
0.0083664665,
-0.02255946,
0.025372725,
0.0063698473,
-0.0016491271,
-0.022866119,
0.0054232036,
-0.041039016,
-0.011953047,
0.005473202,
0.014826312,
0.010459749,
0.0037432436,
-0.022052806,
0.019439533,
-0.00375991,
0.016346276,
-0.0068531693,
-0.0034832498,
0.014119661,
-0.013826336,
-0.002749934,
0.006523177,
-0.03170591,
-0.012506367,
0.02597271,
-0.008126472,
-0.011073068,
0.0076998156,
-0.0054665357,
-0.0007345657,
0.0027166016,
-0.0008316467,
0.0062898495,
0.022586126,
0.028505983,
-0.024919404,
-0.016026283,
0.013499676,
0.008159804,
-0.014346323,
0.015599626,
-0.013219683,
0.019146208,
0.009819765,
0.014412988,
-0.037705764,
-0.001584962,
-0.011159733,
0.045892235,
0.026892688,
0.020839501,
0.03455917,
0.0028315987,
0.0034899164,
-0.018599555,
-0.009979761,
-0.039839044,
-0.03197257,
-0.0039532385,
0.0047265533,
-0.019959522,
0.0050298795,
0.010793075,
-0.02017285,
-0.009013117,
0.0017349584,
0.004286564,
0.0043032304,
0.017306251,
0.00084914634,
0.007826479,
0.0064365123,
-0.008146471,
-0.022706123,
-0.034959164,
-0.009173114,
-0.018546222,
-0.010653079,
0.013586341,
0.0008599794,
0.01085974,
0.014346323,
-0.0013866335,
-0.012173042,
-0.018639553,
0.011166399,
0.18559556,
-0.015959617,
-0.0067365053,
0.03698578,
-0.010333085,
-0.011639721,
-0.003366586,
-0.023786096,
0.032399222,
-0.0019432867,
0.014399655,
0.0041232347,
-0.014706315,
-0.0015191303,
0.037305772,
-0.007506487,
-0.031119255,
0.009113115,
-0.03437251,
-0.0013283015,
0.007086497,
-0.023866095,
0.013666339,
0.009933095,
0.03530582,
0.010233088,
-0.024119422,
0.014359656,
0.0015607959,
-0.0026516032,
-0.023852762,
0.0050965445,
-0.015839621,
0.014172994,
-0.0023216112,
0.0167196,
0.00006989416,
-0.009593103,
0.0054898686,
-0.0069198343,
0.010513081,
0.0052665407,
-0.021532817,
-0.003706578,
-0.010206422,
0.008153138,
-0.0030749263,
-0.0034765834,
0.0010341419,
0.022892784,
-0.036692455,
-0.016026283,
-0.0041765664,
-0.010006427,
-0.024399415,
0.008886454,
0.019719528,
-0.0010866406,
-0.0037165775,
0.03047927,
-0.009893096,
0.0038965733,
-0.030425938,
0.00652651,
-0.016292943,
0.018252896,
-0.0052665407,
0.002353277,
0.014959642,
-0.038079087,
0.00542987,
-0.002853265,
-0.009073116,
0.014079663,
0.0004151984,
-0.023399439,
0.01857289,
0.010853074,
0.016519604,
0.036825784,
0.020639505,
0.0073598237,
-0.004606556,
-0.0040732357,
-0.003499916,
-0.02118616,
0.022146136,
0.015719624,
-0.021746146,
-0.021559484,
0.0013516343,
-0.005076545,
-0.0062431837,
0.0043665622,
0.020652838,
0.017186254,
0.014439654,
0.012586365,
-0.015452963,
-0.022972783,
-0.033012543,
0.061331864,
0.05079878,
0.02114616,
-0.015159637,
-0.013906334,
-0.007113163,
0.023052782,
0.013139686,
-0.01026642,
0.0035732477,
-0.0038165753,
0.00054790353,
-0.0020682837,
-0.021519484,
-0.0017982903,
0.00875979,
-0.013453011,
0.025092732,
-0.035865806,
0.0041199015,
-0.03645246,
0.005376538,
0.023119446,
-0.004406561,
0.0011924715,
-0.036239132,
0.011179732,
0.004813218,
-0.042185657,
-0.00012176792,
0.0046998872,
-0.011073068,
0.0018999545,
-0.011306396,
-0.011053069,
-0.00036853284,
-0.008259802,
-0.0042965636,
0.010913072,
-0.017932903,
-0.01263303,
0.0195062,
0.034585837,
0.0039365725,
0.004419894,
0.014612983,
0.0041765664,
-0.0030815927,
-0.023172779,
-0.024559412,
-0.010159757,
0.00736649,
0.0045932233,
0.01240637,
-0.01473298,
-0.011093068,
-0.04650555,
0.008779789,
0.008459797,
-0.029039305,
0.006723172,
0.027812667,
-0.015626293,
-0.008659792,
-0.012399703,
-0.16767599,
0.010473083,
0.01923954,
-0.008419799,
0.02933263,
0.008099806,
-0.023852762,
-0.0013283015,
-0.0033899187,
-0.008466464,
0.026426034,
-0.0010374752,
-0.01503964,
-0.0036399127,
0.02711935,
-0.0061698523,
0.012579699,
0.017772907,
0.025359392,
0.0060298555,
0.0030432604,
-0.017866239,
0.009513105,
-0.028959306,
-0.011026403,
-0.0041765664,
0.0013941333,
-0.026959354,
-0.0074198223,
-0.013453011,
-0.0046998872,
0.0035332488,
0.028452652,
-0.005299873,
0.0122197075,
0.010159757,
-0.012433035,
-0.023692766,
-0.0034632504,
-0.0012191375,
0.03141258,
0.0334392,
0.010819741,
-0.023199445,
0.00028457653,
0.012299705,
-0.025932712,
0.007413156,
0.030185943,
-0.004356562,
0.04047903,
-0.009439774,
-0.010219756,
0.026906023,
0.021706147,
0.0016857929,
0.017399583,
0.005789861,
0.00078914774,
0.0071331626,
0.0016232944,
0.00036019972,
0.03322587,
0.011339729,
-0.02402609,
-0.020772835,
-0.01897288,
0.03007928,
-0.0195062,
0.019919522,
-0.011686387,
0.00064706785,
0.013759671,
-0.026119374,
0.027652672,
0.007019832,
0.004496559,
0.027919332,
-0.0125197,
0.009606437,
-0.014399655,
0.014066329,
-0.01433299,
-0.025639385,
-0.0076464834,
-0.0061198534,
0.0052565406,
0.027492674,
-0.021599483,
0.0071598287,
-0.001614128,
-0.023412772,
0.0052765403,
-0.024252752,
0.0334392,
0.040985685,
-0.00041811497,
-0.025026066,
0.0022932785,
-0.012913024,
0.010106425,
-0.016159613,
-0.034079183,
0.010926405,
0.030585933,
0.0118530495,
0.012606365,
-0.015212969,
0.040879022,
-0.021919474,
-0.0039332393,
-0.004956548,
0.01450632,
0.009593103,
0.00048082182,
0.040639028,
0.0029232632,
-0.00723316,
-0.012573032,
-0.006566509,
0.06399847,
-0.00017520414,
-0.018932879,
0.0004049903,
0.013959666,
-0.019412868,
-0.13173018,
-0.007813146,
0.039225727,
0.035972472,
-0.016732933,
0.02158615,
-0.008113139,
0.017679576,
-0.026506031,
0.0334392,
-0.0066198413,
-0.017719576,
0.01601295,
0.016666267,
0.0024316085,
-0.0015032974,
-0.008053141,
-0.014412988,
-0.03941239,
0.017999569,
-0.010919739,
0.007206494,
-0.0066498406,
-0.021159492,
0.016666267,
0.009859764,
-0.011059735,
0.02467941,
0.0016099614,
0.0076064845,
-0.0063331816,
-0.0018516222,
0.011386394,
-0.016652934,
-0.01196638,
-0.00033561696,
-0.00036561623,
-0.01831956,
0.025759382,
-0.01517297,
-0.008586461,
0.021746146,
0.011086401,
0.006979833,
0.004173233,
-0.04445227,
-0.03250589,
0.0022066138,
0.00570653,
-0.024586078,
-0.009379775,
-0.027412677,
-0.019932855,
-0.04757219,
0.0045932233,
-0.006336515,
0.008793123,
0.020319514,
-0.007299825,
0.012266372,
-0.023399439,
0.0017966236,
0.009306444,
-0.0056431983,
0.028559316,
-0.023972759,
-0.0094664395,
-0.029225966,
0.01902621,
-0.009379775,
0.0012583032,
-0.0009774766,
-0.031919234,
-0.013246349,
-0.009379775,
-0.01459965,
-0.006473178,
-0.0057398626,
-0.009959761,
-0.014746313,
-0.008059807,
-0.015986284,
0.008979785,
-0.017532913,
0.054665357,
0.0060831876,
0.030372605,
0.00026499367,
0.005956524,
-0.0115863895,
-0.00025332728,
0.031892568,
-0.0041465675,
-0.02986595,
-0.0072798254,
0.006573176,
0.006866502,
0.0039499053,
0.0073998226,
0.024186088,
-0.026332702,
-0.00046582217,
-0.045545574,
0.000584986,
-0.013153018,
0.0033015877,
0.014892977,
-0.0055965325,
0.006019856,
0.0018449558,
-0.0028999306,
0.042452317,
-0.015639625,
0.009226446,
-0.0023099447,
0.006326515,
-0.024719408,
-0.016039615,
0.020012854,
-0.012793027,
-0.00079581427,
0.014479653,
-0.009953095,
-0.008846454,
0.029492626,
-0.005366538,
-0.0023416106,
0.0012899691,
0.01627961,
0.014479653,
-0.006709839,
0.006639841,
0.011559723,
-0.02853265,
0.0041132346,
-0.01154639,
-0.016866263,
-0.014146328,
-0.028719312,
0.021626148,
0.0069931657,
0.04730553,
0.01490631,
-0.028105993,
-0.0035032495,
-0.014612983,
-0.016479606,
-0.008479797,
-0.010493082,
0.0045265583,
0.0021149493,
-0.011666387,
0.028132658,
0.01517297,
-0.019012878,
-0.03047927,
0.0020866166,
-0.0045965565,
0.015626293,
-0.0195062,
-0.022626124,
-0.03282588,
0.01849289,
0.022452796,
0.01503964,
0.01973286,
0.00083622994,
0.0018599555,
-0.05733196,
0.00039082396,
0.008713124,
-0.024279417,
-0.013506343,
-0.0032782548,
0.005969857,
-0.006706506,
0.009613103,
0.016626269,
-0.0120197125,
-0.0037232442,
0.0026749359,
0.030879261,
0.01698626,
0.035945807,
-0.030665932,
0.015719624,
0.030905927,
-0.009546438,
-0.0040999018,
0.03778576,
0.009106449,
-0.0032032565,
-0.011799717,
0.030265942,
0.013233016,
0.00080664735,
0.017412916,
0.008739791,
-0.019799525,
0.025292728,
0.024572745,
0.0041998993,
0.0010799741,
-0.0053432053,
-0.0023566103,
-0.015986284,
-0.010679744,
0.01059308,
-0.0029215966,
-0.028852642,
-0.009053117,
0.0056731976,
0.0017849572,
0.012733028,
0.016386274,
-0.006719839,
0.003576581,
0.028959306,
0.027412677,
-0.012466368,
0.000530404,
0.019052876,
0.025732717,
0.030025948,
-0.021906141,
-0.0038365747,
0.02114616,
0.011073068,
0.02565272,
-0.03565248,
0.025719384,
-0.010186423,
0.025826048,
-0.020719504,
-0.04498559,
-0.0035332488,
-0.0025116066,
-0.0124863675,
0.031039257,
-0.0005033213,
-0.026732692,
0.075678185,
0.012006379,
-0.0030865928,
0.0027216014,
-0.02839932,
0.006473178,
0.027572673,
-0.0020432845,
-0.02906597,
-0.019932855,
0.01910621,
-0.010739743,
0.00237161,
-0.030639267,
-0.0068998346,
0.023746097,
-0.024759406,
0.037759095,
-0.009506439,
0.0024466082,
0.016612936,
-0.014386322,
-0.0013299681,
0.028452652,
-0.023066115,
0.011593056,
0.016559603,
0.0207995,
0.0166796,
-0.01986619,
-0.007019832,
-0.0091331145,
-0.030985923,
0.0031999233,
0.0038765739,
-0.007319825,
-0.0069265007,
-0.049838807,
0.019919522,
0.03303921,
-0.009246445,
-0.005823194,
-0.021786144,
-0.04122568,
-0.000025324915,
0.03799909,
-0.006483178,
-0.0044798926,
-0.006703173
] |
Recent studies have established that during embryonic development, hematopoietic progenitors and stem cells are generated from hemogenic endothelium precursors through a process termed endothelial to hematopoietic transition (EHT). The transcription factor RUNX1 is essential for this process, but its main downstream effectors remain largely unknown. Here, we report the identification of Gfi1 and Gfi1b as direct targets of RUNX1 and critical regulators of EHT. GFI1 and GFI1B are able to trigger, in the absence of RUNX1, the down-regulation of endothelial markers and the formation | [
-0.015164287,
-0.023933025,
-0.005158673,
-0.027244765,
-0.024375485,
0.012663721,
-0.022820173,
0.010270419,
-0.0010642486,
-0.024992246,
0.01708161,
-0.007494992,
-0.0045217997,
0.0014974901,
-0.027057055,
-0.006499459,
0.022136372,
-0.010364274,
-0.008131865,
0.009130751,
-0.02114419,
0.020849219,
-0.014708419,
-0.02259224,
-0.029014602,
0.014118474,
0.028826892,
-0.02027268,
-0.024804536,
-0.036576636,
0.0015402276,
0.013280483,
-0.026131913,
-0.009392204,
0.010317346,
0.010706174,
-0.01182573,
-0.00023317101,
0.0064424756,
-0.008681588,
0.029041419,
0.013903948,
0.0034072718,
0.011121818,
-0.015861494,
-0.004407833,
0.009083823,
-0.0054972214,
-0.018315133,
0.04993086,
0.0018000049,
-0.010163155,
0.0028960973,
-0.0073542097,
-0.02365146,
-0.012536347,
0.004920684,
0.000041768617,
0.0015209538,
0.010967627,
-0.01132964,
-0.009144159,
-0.022136372,
0.0022977716,
-0.002450286,
0.014118474,
-0.0077899653,
-0.00866818,
0.0028541975,
0.010994443,
0.021425756,
0.0004129201,
-0.015472667,
0.00919779,
0.018945303,
-0.020500613,
-0.008902817,
-0.019427985,
0.0024000064,
-0.009975445,
0.01445367,
-0.0064324196,
-0.024201183,
0.018905079,
0.009231309,
-0.01414529,
0.00007379559,
0.034082774,
0.008393318,
0.010659247,
0.022444753,
0.016719598,
0.026118506,
0.0149095375,
0.0019391114,
-0.008876001,
-0.0077899653,
0.033600092,
0.016411217,
-0.03410959,
-0.015874904,
-0.010163155,
0.0041832514,
-0.011530757,
-0.017483845,
0.0107933255,
0.014172105,
0.010076005,
0.008493878,
-0.0017396695,
-0.023195593,
0.020031339,
-0.010592207,
-0.0067877276,
0.019307315,
-0.015526298,
0.041886147,
0.01238886,
-0.009559802,
-0.00019902288,
0.02834421,
0.015378812,
0.00055935903,
-0.028451473,
0.021935254,
0.021412348,
-0.0070257173,
-0.0009821255,
-0.0063419165,
0.00024993083,
0.008467061,
-0.023892801,
0.010672654,
0.008755331,
-0.03791742,
-0.006224598,
-0.013917356,
0.0054737576,
-0.011966513,
-0.03923139,
0.021117374,
0.01645144,
-0.0057218033,
-0.010243603,
-0.0020245865,
0.0077698533,
0.005892753,
-0.0013491657,
0.034645904,
-0.009727401,
0.005363143,
-0.012884951,
0.035611268,
-0.023530789,
-0.0032279417,
0.017095018,
0.010746398,
0.043521903,
0.0004137581,
0.011175449,
0.0077162217,
-0.03365372,
0.033760983,
0.017255912,
0.002926265,
0.021868216,
-0.0040659327,
0.0006967896,
0.021157598,
-0.030543098,
0.0009980474,
0.019991115,
-0.06124709,
0.018274909,
0.014922945,
0.0058558816,
-0.009687177,
0.020044746,
-0.02928276,
-0.025662638,
0.010444721,
0.0045452635,
0.022927435,
-0.021130783,
-0.0081117535,
-0.014172105,
0.024938615,
-0.020044746,
-0.008346391,
-0.024375485,
-0.006566498,
0.03416322,
0.009861479,
0.0134011535,
-0.6264151,
-0.0078503005,
0.019870445,
-0.022793358,
0.025126325,
0.046471633,
-0.0021368773,
-0.01482909,
-0.008219017,
0.019065972,
-0.010739693,
0.021224638,
0.009921814,
-0.016558703,
-0.02032631,
-0.026949793,
-0.009861479,
-0.017604517,
0.026507333,
0.00054259924,
-0.011322935,
-0.0034273835,
-0.005302808,
0.011738579,
0.004062581,
0.026359847,
0.03172299,
-0.025622414,
-0.009968742,
0.023048107,
-0.01257657,
0.02214978,
0.0051921927,
0.031052597,
0.05481132,
-0.010082709,
-0.026574373,
0.026319623,
-0.000032053158,
0.035074953,
-0.025314035,
0.0051117456,
0.024898391,
-0.0034592273,
-0.0059530884,
0.024455931,
0.010840253,
0.007300578,
0.00976092,
0.0034960988,
-0.012087183,
0.011195561,
-0.012281598,
-0.0042771064,
-0.01047824,
0.031803437,
0.027888343,
0.0019022397,
-0.010250307,
-0.00024804537,
0.015325181,
0.02233749,
-0.009894999,
-0.012791096,
0.016008982,
0.0073340978,
-0.014118474,
0.0044312966,
0.018784408,
-0.015177694,
0.021130783,
0.021063743,
-0.0070056054,
-0.002919561,
0.013260371,
0.037756525,
0.000843438,
0.016759822,
-0.011524053,
0.01332741,
-0.013320706,
-0.0013198359,
-0.002718443,
0.021760952,
0.025005654,
-0.0053899586,
-0.023128554,
0.011973216,
-0.012972102,
-0.011966513,
-0.02090285,
-0.0060771112,
-0.013474897,
-0.03472635,
-0.009318461,
0.013810093,
-0.0049173315,
0.027311806,
0.013200035,
-0.043334194,
0.0033385565,
-0.006884935,
0.006626833,
0.0029631364,
0.010263715,
0.026185546,
-0.02114419,
-0.016545296,
0.02810287,
-0.041403465,
-0.009613434,
0.0016382725,
-0.019025749,
-0.008346391,
-0.019468209,
-0.02484476,
0.002926265,
0.0038648148,
-0.0048569962,
-0.030274943,
0.017363176,
-0.011765394,
0.00047220796,
-0.0071061645,
0.031106228,
-0.0014765402,
-0.0054335343,
-0.019562064,
-0.0027435827,
-0.011973216,
0.0024519619,
-0.017349767,
0.039285023,
-0.019830221,
0.024268221,
-0.021747544,
0.017430214,
0.02484476,
0.021224638,
-0.027070465,
-0.025702862,
0.0040055974,
0.0061139828,
-0.029068235,
-0.01257657,
-0.01771178,
0.0058726417,
-0.029121866,
0.021036929,
-0.01114193,
0.0011530757,
-0.015915127,
-0.038534183,
0.018824631,
0.0121542225,
-0.027244765,
0.0021301734,
-0.013850316,
0.0017312896,
-0.0033720762,
-0.0017396695,
0.031159861,
-0.002068162,
0.014105066,
-0.0016726302,
0.009613434,
-0.01602239,
-0.0013835232,
-0.01104137,
-0.011524053,
-0.0010441369,
-0.022055926,
-0.031964332,
0.013166516,
-0.005054762,
-0.0040089493,
-0.0076424787,
0.004032413,
-0.015995573,
-0.015164287,
-0.004216771,
-0.026359847,
-0.02697661,
-0.020406758,
0.014467078,
0.0067039286,
0.018717369,
0.012134111,
0.0150168,
0.017537476,
-0.026359847,
0.009827959,
-0.037407923,
0.02484476,
0.0012486067,
-0.027888343,
0.008554213,
0.018435804,
-0.017738596,
0.03290288,
0.037032504,
-0.029363208,
0.01370283,
-0.010096117,
0.02151961,
-0.014185513,
-0.017631331,
-0.013005622,
0.0015930211,
0.0037139764,
0.004484928,
-0.0011807295,
-0.015874904,
-0.019347537,
0.010022373,
-0.01895871,
-0.006375436,
0.012167631,
-0.015311773,
-0.01633077,
0.007823485,
0.0097877355,
0.020849219,
0.008299463,
0.0055910763,
0.011135225,
0.00013051712,
-0.0074681765,
0.0055273892,
-0.01721569,
0.002631292,
0.0053899586,
-0.00011511902,
-0.01054528,
0.0064223637,
0.0036201214,
0.022699503,
0.0002729756,
0.020058155,
0.008473766,
0.014252552,
-0.014225736,
-0.010994443,
-0.004706158,
0.0045854873,
-0.026560966,
0.037112948,
-0.0036100657,
-0.01839558,
0.0366839,
0.0047363257,
0.026279401,
-0.018757593,
-0.033439197,
0.020634692,
-0.009613434,
0.012274893,
0.012134111,
0.01614306,
0.009559802,
0.011269304,
-0.0043039224,
-0.004588839,
-0.014587749,
0.007863708,
0.010605616,
0.0026748676,
-0.013334114,
-0.039016865,
-0.007950859,
-0.02733862,
-0.00012412743,
-0.001981011,
-0.027486108,
0.020594468,
0.020540837,
0.025957612,
0.010417905,
0.009915111,
0.004498336,
0.005510629,
-0.007267059,
0.018382173,
0.018261502,
-0.017430214,
-0.0054871654,
-0.004210067,
-0.017993344,
-0.012750872,
0.008963153,
0.030489467,
-0.0019558712,
0.009653658,
-0.0045720795,
-0.009821256,
-0.00090586836,
0.01407825,
-0.028746447,
0.008574325,
-0.019039158,
0.017175466,
-0.018516252,
-0.020996705,
-0.004035765,
0.03649619,
0.0036469372,
0.0015326857,
-0.0042670504,
0.009486059,
-0.014882722,
-0.002344699,
-0.006781024,
-0.0054905177,
-0.019052565,
-0.012067071,
-0.0065262746,
0.009479355,
0.0053799027,
0.02233749,
0.0058894013,
-0.018677145,
-0.02871963,
-0.018650329,
-0.002725147,
0.031240307,
0.03040902,
-0.0038178873,
0.024764312,
-0.010860364,
-0.013528528,
-0.012844727,
-0.025139732,
0.015486076,
-0.018355357,
0.030382205,
0.0072603547,
-0.012328525,
-0.011745283,
-0.007796669,
0.01645144,
-0.01201344,
-0.041081674,
0.0021804527,
-0.008084938,
-0.023597829,
0.011155337,
0.022672687,
0.041886147,
0.02259224,
0.0076961103,
0.0162101,
0.02421459,
0.0019525192,
0.004494984,
0.011932993,
-0.00263632,
-0.0043542017,
-0.005058114,
-0.010505056,
-0.022699503,
0.014051435,
0.006747504,
0.022391122,
-0.0048134206,
-0.0011162041,
0.0103843855,
0.020406758,
-0.00960673,
-0.016692782,
-0.025421297,
0.0116313165,
-0.023731908,
-0.00050866057,
-0.030864887,
0.016531888,
-0.02890734,
-0.013521824,
-0.00039322732,
0.013696127,
0.002537437,
0.0038212393,
-0.0112223765,
-0.014105066,
-0.022940844,
-0.008259241,
-0.03148165,
0.011316231,
0.008185497,
0.007722926,
-0.0008250022,
-0.011912881,
-0.018797817,
0.0045553194,
-0.0013793333,
0.025166549,
-0.003573194,
-0.03459227,
0.0068178955,
0.014064842,
0.027941974,
0.031615727,
0.0077162217,
0.0061240387,
0.00866818,
0.0053396793,
-0.025300628,
0.0057955463,
-0.0074547688,
0.00061466644,
-0.0057720826,
-0.010639135,
-0.0135687515,
0.0041866032,
0.009626841,
-0.0011388299,
0.008694995,
0.01645144,
-0.012791096,
-0.020446982,
0.015392221,
0.033117406,
0.0015444176,
-0.012891655,
0.0082793515,
-0.014976577,
-0.03518222,
0.0061441506,
-0.024670457,
-0.02227045,
-0.00063226424,
0.0055843727,
0.01776541,
-0.029255945,
-0.03129394,
0.019575471,
-0.0035095066,
-0.00045880012,
-0.0028307338,
0.0052893995,
0.00019975612,
0.007991083,
0.025099508,
0.009539691,
-0.0077497414,
-0.0007969295,
-0.012348637,
0.036817975,
0.0029379968,
-0.017322952,
0.019843629,
0.023477158,
-0.016102837,
-0.038239207,
0.022511791,
-0.017604517,
0.044701796,
0.016665967,
-0.022042517,
-0.0168939,
0.005467054,
-0.014587749,
-0.0013432998,
0.0043575536,
-0.008031307,
-0.013729646,
0.0013416237,
0.0023212354,
-0.009928518,
-0.00013963027,
-0.033063777,
0.004991075,
0.028880525,
0.02322241,
-0.016464848,
-0.00658661,
0.0076692943,
-0.01721569,
-0.01663915,
-0.0042938665,
-0.041752066,
0.008688292,
-0.026628004,
0.01494976,
0.014989984,
0.04588169,
0.008460358,
0.00435085,
0.018677145,
0.02772745,
0.0035899538,
-0.021680506,
0.012891655,
-0.03555764,
0.015459259,
-0.021036929,
0.0017798931,
0.021573242,
-0.011436902,
0.029068235,
0.038239207,
-0.032366566,
-0.0025156492,
0.0132335555,
-0.043897323,
-0.02658778,
0.029926337,
-0.017899489,
0.0029396727,
-0.04617666,
-0.014252552,
0.044219114,
-0.00907712,
0.016692782,
0.007213427,
0.024737496,
-0.016907308,
0.030114047,
-0.024683865,
0.020232456,
0.0056715235,
0.0036938647,
-0.0068078395,
-0.007836892,
0.026547557,
-0.0087017,
0.006087167,
-0.006522923,
-0.0319107,
0.01257657,
0.005232416,
-0.019240275,
-0.011584389,
-0.0069050463,
-0.0143329995,
0.0008191363,
-0.018489435,
-0.00713298,
-0.035691716,
-0.008058122,
0.0038480551,
-0.025072694,
0.019240275,
0.0012025172,
-0.022914028,
0.019039158,
-0.014279368,
0.00916427,
-0.016800046,
0.04030402,
0.011048075,
0.0059530884,
-0.013153108,
-0.009559802,
-0.001225143,
-0.0022039164,
0.029819075,
0.01520451,
-0.018462619,
-0.035879426,
0.010062597,
0.016089428,
-0.009351981,
-0.02928276,
0.016169876,
0.007340802,
-0.0174034,
0.0068916385,
-0.014359815,
-0.019293906,
-0.01163802,
0.0049575553,
0.011530757,
-0.008245832,
-0.013427969,
-0.010987739,
0.03523585,
-0.017698372,
0.019468209,
0.011410086,
-0.0050413543,
-0.012067071,
-0.019548656,
-0.020286089,
0.0027452589,
-0.013381042,
0.036764346,
-0.01714865,
0.002527381,
0.009419019,
-0.008916225,
-0.006677113,
-0.007521808,
-0.007823485,
0.040196758,
-0.0016726302,
-0.012489419,
0.017872674,
0.001593859,
-0.00038882787,
-0.026038058,
-0.0010541928,
-0.006563146,
-0.033197854,
0.0036335294,
0.018744184,
0.008306168,
-0.001600563,
0.014788867,
-0.033439197,
-0.029926337,
-0.027043648,
-0.03126712,
0.020728547,
-0.047705155,
-0.023557605,
0.012630202,
0.03960681,
-0.002068162,
0.010927403,
0.00021976315,
0.004116212,
0.027392253,
-0.0117989145,
0.02265928,
0.023812354,
0.016545296,
-0.019736366,
-0.0016014009,
-0.0062380056,
-0.013796685,
0.0061139828,
-0.020205641,
-0.0055743167,
0.0116313165,
0.005728507,
0.01035757,
0.014976577,
-0.017430214,
0.014654788,
0.007702814,
0.00602348,
0.009170975,
0.0018603402,
0.0149095375,
-0.011289416,
-0.004012301,
0.015405628,
-0.0009318461,
0.020661509,
0.012811207,
0.0034424674,
0.00044832524,
-0.005098338,
-0.0031340867,
-0.015392221,
-0.011751987,
-0.025354259,
-0.018261502,
-0.0072603547,
0.0005270964,
-0.022444753,
0.0030737512,
-0.011369863,
-0.03022131,
-0.017416807,
0.019722957,
-0.022109557,
0.02284699,
-0.000121927704,
0.006375436,
-0.002158665,
-0.025555376,
-0.03649619,
0.0099553345,
0.00028366,
0.025984427,
0.0032463775,
-0.0059698485,
-0.026507333,
-0.013347522,
-0.05738563,
-0.0029229128,
0.00015031465,
0.015566522,
-0.006925158,
-0.0057921945,
-0.0054905177,
-0.0058022505,
-0.012864839,
0.020889442,
0.0040994524,
-0.0018720721,
0.03448501,
0.010022373,
0.004424593,
-0.0015310097,
-0.033224672,
-0.013608975,
0.012931879,
-0.0029530805,
0.017872674,
0.011135225,
-0.014319591,
0.043361012,
-0.024804536,
0.0057419147,
0.038587812,
0.02015201,
0.007072645,
-0.029148681,
0.0040156534,
0.036254846,
-0.0049307393,
-0.012757576,
0.004910628,
-0.010867069,
0.0093855,
-0.006298341,
-0.0025055932,
-0.00046550404,
0.029041419,
-0.011490534,
0.02721795,
-0.0030586675,
0.013810093,
0.030784441,
0.02208274,
-0.00012339419,
-0.0047698454,
-0.0010173211,
-0.0037977756,
-0.0052994555,
0.00041019663,
-0.014185513,
-0.015995573,
-0.01952184,
-0.022257043,
-0.013535232,
-0.0050480585,
0.024160959,
-0.0016206747,
-0.013468193,
0.017376583,
-0.022310674,
-0.0037240323,
-0.019615695,
-0.0057921945,
-0.009097232,
-0.024978839,
0.00045251517,
-0.010994443,
-0.016102837,
-0.022552015,
-0.0007981865,
-0.013220147,
-0.01351512,
0.002802242,
0.0019508433,
-0.017108425,
0.033868246,
0.19822176,
-0.0135687515,
0.010840253,
-0.006308397,
-0.0038480551,
-0.031133045,
0.024375485,
0.005986608,
-0.0067408,
0.0065698503,
0.012348637,
0.0072603547,
-0.012522939,
-0.0061877263,
0.025568783,
-0.041188937,
-0.023946432,
0.0060569993,
-0.029577734,
-0.008131865,
0.013213444,
0.004122916,
0.0016743062,
0.0021938607,
0.045828056,
0.0030519634,
-0.013079365,
0.022686094,
0.03665708,
0.0012284949,
-0.024670457,
0.017752003,
-0.004783253,
0.014788867,
0.008131865,
-0.0030553155,
-0.010149748,
0.0034458193,
0.0019240276,
-0.008366503,
-0.00018100608,
0.006469291,
-0.020205641,
-0.0063285087,
-0.001880452,
0.017926306,
-0.019307315,
-0.024616826,
-0.013099477,
-0.008453654,
-0.04285151,
0.025005654,
0.01407825,
0.0168939,
-0.0039955415,
-0.0004520962,
0.00803801,
0.020353127,
0.003194422,
0.008983265,
-0.0018368765,
0.020661509,
-0.030918518,
0.010900588,
-0.019495025,
0.024911799,
-0.022806766,
-0.004632415,
0.019052565,
-0.015378812,
-0.006965382,
0.005936329,
-0.014185513,
0.0010206731,
-0.008862593,
-0.015325181,
0.017121833,
0.016652558,
0.014654788,
0.028987788,
0.011819026,
-0.0056614676,
-0.0281565,
0.005188841,
-0.01839558,
-0.035959873,
0.018744184,
0.016411217,
-0.021224638,
-0.010880476,
0.026011243,
0.0013600595,
0.0034458193,
-0.004116212,
0.012033552,
-0.010364274,
-0.012067071,
0.017819043,
0.01370283,
0.011926289,
-0.04311967,
0.07476221,
0.0076759984,
0.015687194,
-0.010203379,
0.013086068,
-0.019816812,
0.019548656,
-0.017805634,
-0.015043616,
0.010303939,
-0.008192201,
0.012248077,
-0.0069989017,
0.0055977805,
0.0011689976,
0.004404481,
-0.010243603,
0.012462603,
-0.00430057,
-0.015486076,
-0.01726932,
0.0074882885,
0.03233975,
-0.025086101,
-0.0131598115,
-0.010531872,
0.0038882785,
-0.0230347,
-0.024227997,
-0.0016156468,
0.011282712,
0.016853677,
-0.009419019,
0.016183283,
-0.013246963,
0.0055843727,
0.002150285,
-0.01066595,
0.0394191,
-0.01563356,
-0.014064842,
0.00029958182,
0.012073776,
0.002539113,
-0.008198905,
0.024227997,
-0.0015888311,
-0.021559834,
-0.014534118,
0.004498336,
-0.011497238,
0.010746398,
-0.007059237,
0.03496769,
-0.026507333,
-0.006452531,
-0.038453735,
0.023235817,
-0.0025240292,
-0.01914642,
0.034699533,
0.001315646,
-0.029255945,
-0.00373744,
-0.0050279466,
-0.16904627,
-0.0019223515,
0.025233587,
-0.023289448,
0.05288059,
0.008594437,
-0.008259241,
0.0024536378,
-0.004803365,
0.020768771,
0.058726415,
-0.0033536402,
-0.044648163,
-0.04303922,
-0.0071664997,
0.013092773,
-0.010686062,
0.035638086,
0.016116245,
0.0109207,
0.011048075,
-0.0073743216,
0.020219048,
-0.017684964,
0.0070257173,
0.0068078395,
0.006408956,
-0.00079651055,
-0.01639781,
-0.009707289,
-0.0023212354,
-0.0029312929,
0.013347522,
-0.014601156,
-0.0065061627,
-0.015928535,
-0.0021016817,
0.005986608,
0.001034081,
0.012744169,
0.01771178,
0.015995573,
-0.010974331,
0.016947532,
-0.0030435836,
0.030382205,
-0.020393351,
-0.011718467,
0.034243666,
0.0040022456,
0.018489435,
-0.006308397,
-0.005738563,
0.0077296295,
0.01952184,
0.0027435827,
-0.008312872,
0.013917356,
0.027083872,
-0.0034072718,
0.008004491,
0.00027905102,
0.034324113,
0.01016986,
0.016169876,
-0.02989952,
-0.008299463,
0.010002262,
-0.037756525,
0.01242238,
-0.023141962,
-0.028183317,
0.005839122,
-0.01332741,
0.039874967,
0.007991083,
-0.028585551,
0.010598911,
-0.0069184545,
0.018006753,
-0.016759822,
0.0128983585,
-0.009144159,
-0.020299496,
-0.011845842,
0.010531872,
0.006375436,
0.008138569,
0.0034860428,
-0.014882722,
0.040786702,
-0.025582192,
-0.015124063,
0.0021519612,
0.030569915,
0.016746413,
0.005842474,
-0.019883852,
0.0050380025,
0.02853192,
0.038829155,
-0.023758722,
0.0026832474,
-0.017135242,
0.045559898,
0.012744169,
0.0006850577,
0.018502843,
0.06162251,
0.006392196,
-0.017363176,
0.007823485,
-0.013092773,
0.027861528,
-0.0024083864,
0.02202911,
-0.011718467,
0.0011849194,
-0.007139684,
-0.043441456,
0.058243733,
0.004900572,
-0.015861494,
0.03604032,
-0.0041798996,
-0.03590624,
-0.11605841,
0.0014564286,
0.003573194,
-0.008078234,
0.004166492,
0.017376583,
-0.00017514013,
0.021573242,
0.0037307362,
0.024911799,
-0.04008949,
-0.0013642495,
0.008118457,
-0.0075821434,
0.022377715,
0.012134111,
0.01977659,
-0.021506203,
-0.03148165,
0.038748708,
-0.0015779372,
-0.0052357684,
-0.018060384,
-0.006502811,
-0.002626264,
0.012951991,
-0.03553082,
-0.008674883,
0.008721811,
0.013052549,
0.0056849313,
-0.013984395,
0.03215204,
-0.00694527,
-0.0087821465,
-0.018677145,
0.0013240259,
-0.036201216,
0.034136403,
-0.031991147,
0.0030217958,
0.017135242,
0.017027978,
0.013944171,
0.006670409,
-0.02496543,
-0.026333032,
0.020755364,
0.015539707,
-0.025501745,
-0.03467272,
-0.04510403,
-0.02778108,
-0.011497238,
0.029390024,
0.00226928,
0.011604501,
0.022176595,
-0.027445884,
-0.010712878,
0.014708419,
-0.02146598,
-0.004494984,
0.016907308,
0.010867069,
-0.0112223765,
-0.013689422,
-0.03477998,
0.02446934,
-0.024227997,
-0.019830221,
-0.0010181592,
0.0025927443,
0.0017002838,
-0.020232456,
0.011886066,
0.002068162,
-0.012884951,
-0.0042603468,
-0.011001147,
-0.027392253,
-0.034055956,
0.019508433,
-0.03266154,
0.018864855,
-0.0035262664,
0.0003557272,
-0.022176595,
0.00747488,
-0.025863757,
-0.00093519804,
0.03880234,
0.0063620284,
-0.020916257,
0.0010525167,
0.009660361,
0.029148681,
0.002061458,
-0.0071664997,
0.015740825,
-0.005621244,
-0.023436934,
-0.064625874,
0.013126292,
-0.0068480633,
-0.0038815746,
0.02341012,
-0.017242504,
0.017121833,
-0.0125631625,
-0.0033100648,
0.021305086,
-0.003760904,
0.0017262616,
-0.014118474,
0.0021687208,
-0.026681636,
0.004686046,
0.022243636,
0.01088718,
0.030435836,
0.020379944,
0.0011254221,
-0.0067072804,
-0.010900588,
0.0022726317,
0.012100591,
-0.0113899745,
0.0020011228,
0.0058156583,
-0.007307282,
-0.016491665,
0.004779901,
-0.033385564,
-0.020849219,
-0.0101229325,
0.0038748707,
-0.01759111,
0.0055910763,
0.027647002,
0.025300628,
0.018543066,
-0.018730776,
0.000845114,
0.026507333,
0.0040826923,
0.017979937,
0.0067139845,
-0.008011195,
-0.0040893964,
-0.0072871703,
-0.009975445,
0.032768805,
0.008795555,
0.0002627102,
-0.00882237,
-0.0068983426,
-0.012268189,
0.00023673248,
-0.010042485,
0.008185497,
0.010806733,
0.020500613,
0.02227045,
-0.010471537,
-0.0075486237,
-0.007226835,
-0.020581061,
-0.02503247,
-0.0142391445,
0.025944203,
-0.035504006,
-0.0426638,
-0.021291677,
-0.0006867337,
0.013535232,
0.021693913,
0.008064826,
-0.0034156516,
-0.0037072725,
-0.019133013,
0.016907308,
0.025434704,
-0.021600058,
-0.01583468,
0.019924076,
0.02660119,
0.0067374483,
-0.004116212,
0.01563356,
-0.011068186,
0.009526283,
-0.014574341,
-0.0006498621,
0.017550886,
0.011255896,
0.027231358,
0.043655984,
-0.002063134,
0.029202312,
-0.0035195625,
0.03397551,
0.0032145337,
0.0022508441,
0.023664868,
-0.011966513,
-0.0030150919,
0.03145483,
-0.014051435,
-0.045962136,
-0.026333032,
-0.018288318,
0.0077899653,
-0.0034039197,
-0.000281146,
-0.0025055932,
-0.008829074,
-0.008332984,
-0.020701732,
-0.018771,
-0.0022240283,
0.03279562,
0.02791516,
0.01989726,
-0.011215673,
-0.003938558,
0.014775459,
-0.00089832646,
0.02189503,
-0.01095422,
0.045962136,
-0.024442524,
0.015941942,
0.030972151,
-0.015070432,
-0.023611236,
-0.010203379,
0.0041698436,
0.00014109675,
0.015459259,
-0.010431313,
0.086722024,
0.009861479,
-0.026252585,
-0.017886082,
-0.015660377,
0.015298366,
-0.007689406,
0.01607602,
-0.03536993,
-0.044406824,
0.016370993,
-0.017497255,
-0.011530757,
-0.03960681,
-0.019548656,
0.014735235,
0.0047698454,
0.0022357602,
0.010102821,
0.00435085,
0.006871527,
-0.010981035,
0.014681604,
0.007139684,
-0.03523585,
-0.00822572,
0.020165417,
-0.010692766,
0.006003368,
-0.011490534,
0.0038648148,
-0.0003842189,
-0.026949793,
0.0104581285,
0.0004319844,
-0.0031776621,
-0.011711763,
-0.017430214,
0.030194495,
0.015848087,
0.014936353,
0.0065597943,
0.005467054,
-0.011356455,
-0.0054033664,
0.00020436507,
-0.02264587,
-0.0024100624,
-0.01708161
] |
In a diverse group of organisms that includes Caenorhabditis elegans, Drosophila, planaria, hydra, trypanosomes, fungi and plants, the introduction of double-stranded RNAs inhibits gene expression in a sequence-specific manner. These responses, called RNA interference or post-transcriptional gene silencing, may provide anti-viral defence, modulate transposition or regulate gene expression. We have taken a biochemical approach towards elucidating the mechanisms underlying this genetic phenomenon. Here we show that 'loss-of-function' phenotypes can be created in cultured Drosophila cells by transfection with specific double-str | [
-0.040881526,
-0.015868308,
0.0021154364,
-0.007535079,
-0.00045614623,
0.009002864,
-0.011234979,
0.009341063,
-0.015043102,
-0.020806018,
-0.005840701,
-0.00081675116,
0.0074200914,
0.003591676,
0.012567484,
0.022239983,
0.031006107,
-0.009557511,
0.02125244,
0.0052589984,
-0.033332918,
0.022023534,
0.000768135,
-0.01746461,
-0.0012995306,
0.014014977,
0.002201677,
-0.03766187,
-0.017775752,
-0.015651861,
0.008394105,
-0.007690651,
-0.006290506,
-0.015110742,
-0.003608586,
-0.023917452,
0.0045995098,
-0.012892155,
0.017681057,
-0.0021222003,
0.032818854,
0.011985782,
-0.019466748,
0.014136729,
-0.005360458,
0.010118921,
-0.0074336194,
-0.00026612054,
0.013588846,
0.01824923,
0.017045243,
0.0135820815,
-0.016301204,
-0.012986851,
-0.020034924,
0.01853332,
0.0064798975,
0.011126755,
0.006753839,
-0.00015610008,
-0.019602029,
0.009882182,
-0.028814577,
0.006625323,
-0.011843737,
0.012012837,
0.021590639,
-0.005309728,
-0.0050121127,
-0.0033735374,
0.03817593,
0.02033254,
-0.008475273,
0.020089036,
0.003936639,
-0.026433652,
-0.0016757773,
0.029653309,
0.013636193,
0.004051627,
0.02072485,
-0.0034597784,
-0.0029710804,
0.0061281705,
0.020346066,
-0.0022828449,
0.0048091933,
0.035470337,
-0.00009030977,
-0.01492135,
0.022131758,
0.027975842,
0.006730165,
0.03657963,
-0.018276287,
-0.004474376,
0.004947855,
0.03812182,
-0.01322359,
-0.016355315,
-0.0050898986,
0.007724471,
-0.0068350066,
-0.009023156,
-0.011586706,
0.0028070537,
0.0063885837,
-0.0047246437,
-0.0027461778,
-0.025689615,
-0.020697793,
0.015016046,
0.0077718184,
-0.049539424,
0.03373876,
-0.003126652,
0.033955205,
0.0078124027,
-0.02072485,
-0.018289816,
0.020400178,
0.008664665,
0.014704904,
-0.038960554,
0.0247156,
0.009909238,
0.0028628567,
0.023308692,
-0.022429373,
-0.008475273,
0.019953756,
0.026974771,
0.009401939,
0.0137105975,
-0.0289228,
0.0042444007,
-0.034631602,
-0.017099354,
-0.0047314074,
-0.0359844,
0.007115712,
0.029707422,
-0.036282014,
-0.00536384,
0.018100424,
0.01439376,
0.032034233,
0.013947337,
0.016274149,
0.008739068,
-0.004914035,
-0.014150256,
0.017180521,
-0.0125269005,
0.015448942,
0.022943437,
0.0073659797,
0.030302653,
-0.006182282,
0.0018364219,
0.013920281,
-0.013446802,
0.008191186,
0.017153466,
0.012256341,
0.02612251,
-0.022997549,
0.010781792,
0.0026447182,
-0.00038364477,
-0.0063412357,
0.010842668,
-0.031303722,
0.032331847,
-0.012709527,
0.01906091,
-0.01176257,
0.015421886,
-0.016625876,
-0.018330399,
-0.009280187,
0.011464954,
0.010227146,
0.007623011,
-0.0034377954,
-0.0032906786,
0.00719688,
-0.0012115987,
0.0149889905,
-0.015178382,
-0.015164854,
0.0075147874,
0.025107913,
0.003584912,
-0.61817414,
-0.008387341,
0.027894674,
-0.029545086,
0.03038382,
0.01846568,
-0.001386617,
-0.00716306,
-0.00011519912,
0.024215067,
-0.011059116,
0.0007423473,
0.03511861,
-0.024363874,
-0.031628393,
-0.040638022,
0.004511578,
-0.013588846,
0.029977981,
0.017843392,
-0.015164854,
0.005485592,
0.0052894363,
0.016098283,
0.01232398,
0.015868308,
0.012756876,
-0.0019277357,
-0.008346757,
0.020251371,
-0.024661489,
0.030410876,
-0.023971563,
0.003113124,
0.049025364,
0.020643681,
0.0037912135,
0.026433652,
0.021374192,
0.026163094,
-0.020643681,
0.016314732,
0.023714531,
0.008881113,
-0.015137798,
-0.0011777788,
-0.0057392414,
0.0019192807,
0.021982951,
-0.0055194115,
-0.003153708,
0.03184484,
-0.032034233,
-0.0035105082,
0.023538668,
0.012946267,
0.031763673,
-0.031871896,
0.039095834,
0.009171964,
-0.0070142522,
0.0101595055,
-0.010565344,
-0.030437931,
-0.01318977,
-0.0013671705,
-0.0127501115,
0.02832757,
0.009368119,
-0.00010299224,
0.03479394,
0.038527656,
0.008218242,
0.012445732,
0.0012217448,
0.04339773,
0.013771473,
0.007656831,
-0.013670013,
0.037364252,
0.009158435,
-0.005884667,
-0.041422643,
0.0005783207,
0.044101182,
-0.0075621353,
-0.015002519,
0.021076577,
-0.022551125,
-0.009821306,
0.017572833,
0.017166995,
-0.00039062012,
-0.018844461,
-0.015935948,
0.0071901157,
-0.003980605,
0.009449287,
0.00042549692,
-0.0099971695,
-0.03192601,
-0.0014982227,
-0.0077718184,
-0.014136729,
0.0032264208,
0.0038960553,
-0.031493112,
0.019236773,
0.035010386,
-0.022645822,
-0.0041801427,
0.00058212545,
-0.020454291,
-0.0042274906,
-0.004914035,
-0.025824895,
0.026081925,
0.00022004088,
-0.005904959,
-0.058711387,
-0.018398039,
-0.0072374637,
-0.0025703143,
0.0011380404,
0.0067876587,
0.012533664,
-0.01746461,
-0.025175551,
-0.02079249,
0.0042680744,
0.024336819,
-0.008664665,
0.008380577,
-0.010152741,
0.003206129,
0.011992545,
0.014447872,
0.017505193,
0.017532248,
-0.01965614,
-0.022929909,
-0.0062025744,
-0.00060114916,
0.00018051385,
-0.0084955655,
-0.019804947,
-0.0149889905,
0.0011448044,
0.013054491,
-0.008651136,
0.03192601,
-0.0133250505,
-0.00979425,
0.015070158,
0.008820237,
-0.013406218,
-0.029734477,
-0.03271063,
-0.007920627,
-0.013500914,
0.013345342,
0.0011913069,
-0.0061247884,
0.0047077336,
-0.03317058,
-0.021103634,
0.018695654,
-0.0029220416,
-0.007981502,
-0.022551125,
0.0069229384,
-0.0065170997,
-0.0043188045,
0.009970114,
0.00042465143,
0.018073367,
-0.007677123,
0.02878752,
-0.013122131,
-0.007934154,
-0.007122476,
-0.019439694,
-0.024201538,
-0.014948406,
0.020440763,
0.0015396521,
0.023633363,
0.01432612,
0.033549365,
0.030492043,
0.0056411633,
-0.008049142,
-0.008603789,
0.013162714,
-0.012533664,
-0.011302619,
0.022754045,
0.013453566,
-0.0034039754,
0.042531937,
0.025040273,
-0.0123578,
-0.007819166,
-0.033143528,
0.004958001,
-0.025162024,
0.0218612,
-0.010037754,
0.01152583,
0.023917452,
0.0059861266,
0.018343927,
-0.017911032,
-0.015678916,
-0.00077447627,
0.009943058,
-0.016693514,
-0.00629727,
-0.009124615,
-0.002727577,
-0.015503054,
-0.0090366835,
0.018100424,
0.00016001052,
-0.029815646,
0.023213996,
0.0011067571,
0.007582427,
0.0032298027,
-0.00809649,
-0.010051281,
-0.0038317975,
-0.0024485625,
-0.0012183628,
0.00806267,
0.020778961,
-0.0038013596,
-0.015543637,
0.043776512,
-0.0017417261,
-0.019169133,
0.011059116,
0.006780895,
0.013277702,
0.01342651,
0.022226455,
0.027028883,
0.0068011866,
0.0014483383,
0.015110742,
-0.0047381716,
0.01492135,
-0.033062357,
-0.011945197,
0.0027309589,
-0.010179797,
0.01680174,
0.009307243,
0.042153154,
0.008827,
-0.0017620181,
-0.011985782,
0.0068180966,
-0.02125244,
-0.009063739,
-0.0051372466,
0.019480277,
0.018492734,
-0.03511861,
0.003082686,
-0.03739131,
-0.02052193,
0.0064021116,
0.0046367114,
0.01732933,
0.0023538668,
-0.0037912135,
0.022902854,
0.013514441,
0.002249025,
0.0074403835,
-0.017491665,
0.027921729,
0.018343927,
-0.0028408736,
-0.030329708,
-0.003153708,
0.0076703588,
0.001800911,
0.018370982,
0.024729129,
0.00843469,
0.023836283,
0.016774682,
-0.0050459327,
0.010328605,
0.025392,
-0.039799288,
0.01016627,
-0.019710252,
0.014339648,
-0.015097214,
0.0037438658,
-0.00093004794,
0.02744825,
0.0055498495,
-0.0020900713,
-0.0155977495,
0.00002486293,
-0.022672877,
-0.0046096556,
-0.008055906,
-0.0012082168,
-0.044885803,
-0.009658971,
0.011099699,
-0.006412258,
-0.0014703212,
0.018425094,
0.006391966,
-0.029355694,
-0.03812182,
0.009476343,
-0.013757945,
0.041828483,
0.011606998,
-0.025621975,
0.022158815,
-0.0051473924,
0.0057088034,
-0.011349967,
-0.020427234,
0.018086895,
-0.034442212,
-0.006709873,
0.0029541703,
0.0059658345,
0.0030099733,
0.0032619317,
0.021766504,
-0.008569969,
-0.028516961,
-0.008975808,
0.013284466,
0.012445732,
0.008373814,
0.011891086,
0.03419871,
0.024472097,
-0.007271284,
0.0057527693,
0.01519191,
0.009023156,
0.0053976597,
-0.0006032629,
0.0031165062,
0.008373814,
0.0144614,
-0.002238879,
-0.02011609,
0.0061856643,
0.021428304,
0.0023217378,
0.005039169,
0.019804947,
0.015530109,
0.009909238,
-0.010842668,
0.011059116,
-0.02652835,
-0.012202228,
0.02832757,
-0.048294853,
-0.022497013,
0.019574972,
-0.020400178,
0.0064900434,
-0.01705877,
0.030681435,
-0.003145253,
-0.008752597,
0.018912101,
-0.005685129,
-0.021671807,
-0.012337509,
-0.022402318,
0.013879697,
-0.0069330847,
-0.024945576,
-0.01166111,
0.005813645,
-0.0018313489,
-0.022334678,
-0.023836283,
0.006222866,
-0.027461778,
-0.02811112,
0.0042951303,
0.009171964,
0.023971563,
0.008448217,
-0.026785381,
-0.009916002,
0.012242813,
-0.007751527,
-0.022754045,
0.014948406,
-0.034739826,
0.032818854,
-0.0031858368,
0.00614508,
-0.018195119,
-0.029166304,
-0.02637954,
0.008806708,
0.0029727714,
0.031303722,
0.015773613,
-0.013757945,
0.014731959,
0.02571667,
0.023998618,
0.007947682,
-0.022699933,
0.0000049375767,
-0.029490974,
-0.018546846,
-0.026108982,
-0.015016046,
-0.042721327,
0.0059962724,
0.012371329,
-0.0011076025,
-0.007555371,
0.020941297,
-0.009016392,
0.010220381,
0.011133519,
0.030194428,
0.018276287,
-0.0075621353,
0.02992387,
-0.015124271,
0.008948752,
-0.0041733785,
0.006845153,
0.010632984,
0.0060503846,
-0.03265652,
0.025216136,
-0.008394105,
-0.02344397,
-0.0400969,
-0.013656486,
-0.006351382,
0.051676843,
0.022564653,
-0.043208335,
-0.008725541,
0.008576733,
0.0037810677,
0.00448114,
-0.0006425786,
-0.032791797,
-0.009097559,
-0.005387514,
0.017031714,
-0.01439376,
-0.0025280393,
-0.03885233,
0.0133588705,
0.010741208,
0.0025584772,
0.012655416,
0.00044684575,
-0.015503054,
-0.011444663,
-0.019209716,
0.0034361044,
-0.051271006,
-0.0068350066,
-0.0094222305,
0.039934568,
0.01619298,
0.013385926,
0.0007846223,
-0.010903544,
0.03390109,
0.007176588,
0.0036559338,
0.0059083407,
0.0136767775,
-0.008739068,
0.0008683266,
0.033684645,
0.01013245,
0.0060368567,
-0.022767574,
0.024891464,
-0.0035950579,
-0.016368844,
-0.027096523,
-0.0025770783,
-0.02692066,
-0.033684645,
0.017248161,
-0.0033380266,
0.0027664697,
-0.026203677,
0.00041704194,
0.032764744,
-0.02079249,
0.017315801,
-0.0043593883,
0.01658529,
0.0024096696,
0.023295164,
-0.0072848117,
0.03392815,
-0.032683574,
-0.007629775,
0.0069871964,
-0.013636193,
0.012283397,
-0.010423301,
0.01685585,
-0.0051237186,
0.0034225765,
-0.0012132898,
0.0024316525,
-0.026501292,
0.0016301203,
-0.016544707,
-0.010524761,
-0.03904172,
-0.012161645,
-0.023917452,
-0.053895433,
-0.006412258,
0.023092244,
-0.003676226,
0.02012962,
-0.025594918,
-0.026839493,
0.022862269,
-0.0020089035,
0.025635503,
-0.017356385,
0.0046265656,
0.03146606,
-0.013081547,
-0.024877936,
-0.015475998,
0.0037540116,
-0.009111088,
0.039420504,
0.024566794,
-0.0231193,
-0.026623044,
0.013879697,
0.009882182,
-0.0023555576,
-0.02552728,
0.00065103354,
-0.0025466403,
-0.008799944,
-0.00016751431,
-0.0019395726,
-0.013771473,
0.02712358,
-0.02439093,
0.011539359,
-0.018722711,
-0.0141232,
-0.000079793885,
0.009063739,
0.0054585356,
0.020900713,
0.010578873,
0.0095507465,
-0.015246022,
-0.00816413,
0.0038622355,
0.00014532,
-0.007183352,
0.030951995,
-0.00799503,
-0.0038689994,
0.009205784,
0.0031773818,
0.005685129,
0.0046434756,
-0.02498616,
0.04204493,
-0.027231803,
-0.011194395,
0.0019209717,
0.006740311,
-0.006780895,
-0.0060436204,
-0.004078683,
-0.00307254,
-0.012283397,
-0.008509093,
0.028814577,
0.0101595055,
-0.008691721,
0.00041936708,
-0.023335747,
-0.004890361,
-0.012898919,
-0.0337117,
0.025080856,
-0.01439376,
0.00072712835,
-0.004034717,
0.026568932,
0.031357832,
0.014934879,
0.00014711668,
0.0033853746,
0.025554335,
-0.019399108,
0.014109673,
-0.0048261033,
-0.023403388,
-0.037743036,
0.023701003,
-0.004048245,
-0.037310142,
0.02938275,
-0.03471277,
-0.02338986,
-0.015827725,
-0.019209716,
0.009753666,
0.005455154,
-0.022348206,
0.016531179,
0.0020917624,
0.009226075,
-0.008022086,
-0.011174103,
0.014488456,
-0.008265589,
0.0073186317,
0.01189785,
0.004075301,
0.004802429,
-0.0051744482,
0.0021830762,
0.006767367,
0.0013587155,
-0.038365323,
-0.013812057,
0.009591331,
0.00004713652,
0.0033244987,
0.014474927,
-0.009341063,
-0.01651765,
0.004991821,
0.00077320804,
-0.00034115848,
-0.024012147,
-0.0077718184,
0.018803878,
0.0060639125,
-0.0046130377,
0.0028831486,
-0.007873278,
-0.027502364,
-0.040475685,
0.000042222062,
0.010436829,
0.04104386,
0.013541498,
-0.0063682916,
0.008319701,
-0.00030881818,
-0.03179073,
-0.016409427,
0.017883977,
0.010112157,
0.008184422,
0.032331847,
0.011268799,
-0.00972661,
-0.010112157,
0.01359561,
0.015841253,
-0.015530109,
0.00035891394,
0.010971184,
0.009949822,
0.0120466575,
-0.046806775,
-0.016030645,
0.035930287,
-0.026366014,
-0.04012396,
0.017694585,
-0.008333229,
0.013318286,
-0.027705282,
-0.006780895,
0.0028865305,
0.004034717,
0.01746461,
-0.023308692,
-0.010375953,
0.0036694617,
-0.0009520309,
-0.03252124,
0.010842668,
-0.013399454,
0.005928633,
0.007852986,
-0.03317058,
-0.013845877,
0.018479208,
-0.009178728,
0.0117896255,
0.018898575,
0.007846222,
0.009834834,
-0.005323256,
-0.00843469,
-0.02006198,
-0.018709183,
0.0050763707,
0.005252234,
0.017965144,
0.0020562515,
0.011214687,
-0.011018531,
0.0015540256,
-0.040746246,
-0.0060334746,
0.007663595,
-0.0105924,
-0.018398039,
-0.0019497187,
0.005749387,
0.013216826,
-0.0054280977,
-0.008049142,
0.014244952,
-0.030897884,
-0.0034733063,
0.00616199,
0.0033684645,
0.027975842,
0.020386651,
0.009882182,
-0.0062634503,
-0.008887876,
0.0010450357,
-0.03265652,
-0.0014906132,
0.18830934,
-0.0039636954,
0.017748697,
0.003990751,
-0.0136767775,
-0.018330399,
0.016679987,
-0.018912101,
-0.013311522,
0.0075283153,
0.017816337,
-0.007690651,
-0.0066050314,
0.001775546,
0.0051068086,
-0.036227904,
-0.015895365,
-0.004907271,
-0.0036694617,
-0.0018651688,
0.006334472,
-0.0047009694,
-0.0127501115,
-0.003080995,
0.057953823,
0.0013849259,
-0.039231114,
0.021617696,
-0.0016453393,
0.0025720051,
-0.032737687,
-0.017424025,
0.010781792,
0.003544328,
0.026677156,
0.006290506,
-0.003608586,
0.0029507885,
0.005434862,
-0.030492043,
0.0024925284,
0.022889325,
-0.0011828518,
-0.0024451804,
0.016639402,
-0.0032568588,
-0.008698485,
-0.020954825,
-0.01712641,
-0.013798529,
-0.058981948,
0.016896434,
-0.0037168097,
0.033224694,
0.022091174,
0.0026514821,
0.008197949,
0.018898575,
0.0015624805,
0.032223623,
-0.02132008,
0.014217896,
-0.011823446,
0.009530455,
-0.00078631326,
0.035497393,
-0.027231803,
0.03317058,
0.018100424,
-0.0072848117,
-0.0019108257,
-0.022632293,
-0.019574972,
0.009537219,
-0.019250302,
-0.009415467,
0.029463919,
0.012175173,
0.026907131,
0.019317942,
-0.016233563,
-0.0019970664,
-0.047834903,
0.017369913,
0.0033481726,
-0.05351665,
0.030248541,
-0.009408703,
-0.022929909,
-0.0020055214,
0.009733374,
-0.023917452,
-0.024485625,
0.004153087,
0.02685302,
-0.00799503,
-0.006581357,
0.0016563308,
-0.0077177067,
-0.035632674,
-0.03630907,
0.06883031,
-0.017626945,
0.015949477,
-0.011904613,
0.02004845,
0.0026058252,
-0.00534693,
-0.0039163474,
-0.026000759,
0.009185491,
-0.011485246,
0.034739826,
-0.012026365,
0.0016774683,
0.0087187765,
0.020873658,
-0.026257789,
0.048890084,
-0.007541843,
-0.012073713,
-0.008793181,
-0.0028002898,
0.02018373,
-0.005015495,
-0.0028036716,
-0.030492043,
0.009239604,
-0.006131552,
-0.028084066,
0.010328605,
-0.0057392414,
-0.004153087,
0.008752597,
0.01322359,
-0.022334678,
0.0305191,
0.0010331987,
-0.0135482615,
-0.0063243257,
-0.017965144,
-0.011721985,
-0.0021323462,
0.009023156,
0.0052894363,
-0.025270248,
0.018492734,
0.005975981,
-0.0037844495,
0.0025297303,
-0.024526209,
-0.015070158,
-0.005928633,
-0.00061044964,
0.0029321874,
-0.0042241085,
-0.000081854785,
-0.024688546,
-0.0073186317,
0.01519191,
-0.04296483,
0.0022912999,
0.011667874,
-0.0138391135,
0.013061255,
-0.0029254234,
-0.17045242,
0.012452496,
0.0047787554,
-0.029490974,
0.038202986,
0.009442523,
0.022605238,
-0.0015540256,
-0.0017053697,
0.025351416,
0.02092777,
0.014190841,
-0.027475307,
-0.04956648,
0.025148496,
0.019358525,
-0.026798908,
0.030897884,
0.023376333,
0.009604858,
0.027137108,
-0.028868688,
0.012107533,
-0.03990751,
-0.0014111364,
0.025608446,
0.018195119,
-0.03376581,
-0.0022896088,
-0.028029954,
-0.018303344,
0.018979741,
-0.0048396313,
-0.0231193,
0.028084066,
0.0014973772,
-0.005485592,
-0.00840087,
-0.01072768,
0.024756184,
0.02685302,
0.028949855,
-0.018357456,
-0.010977947,
-0.014447872,
0.020995408,
0.00039484762,
-0.015002519,
0.008827,
-0.0037472476,
-0.00077193975,
-0.011809918,
0.0051169544,
-0.008089726,
0.0072374637,
-0.01103206,
0.000055485812,
0.041503813,
0.0024790005,
-0.023227524,
-0.004061773,
-0.033468198,
0.038933497,
0.0020291954,
0.015273078,
-0.015827725,
-0.012114297,
0.0066794353,
-0.01183021,
0.0066354694,
-0.031276666,
-0.003919729,
0.0018296579,
-0.013893225,
0.009652207,
0.018709183,
-0.019561443,
0.008421161,
-0.014096145,
-0.012831279,
-0.024201538,
0.0069939606,
-0.024769712,
-0.015381302,
0.0006379283,
-0.014664319,
0.013304758,
0.02464796,
-0.00923284,
0.020021396,
0.027204746,
-0.004832867,
0.007223936,
-0.0035713841,
0.0017535631,
0.01838451,
0.012134589,
-0.0010763191,
-0.003160472,
0.014136729,
0.01746461,
-0.018168064,
0.0029964454,
0.00986189,
0.018736238,
-0.010071574,
-0.01276364,
0.008143838,
0.05757504,
0.0037438658,
-0.007981502,
0.008759361,
0.004558926,
0.027407667,
-0.0005335093,
0.026433652,
-0.016612347,
-0.013717362,
-0.019940227,
-0.022497013,
0.069533765,
0.013020671,
-0.00083197013,
0.010260965,
-0.0008340839,
-0.023917452,
-0.13538793,
-0.025770783,
0.01256072,
-0.0020089035,
-0.013920281,
0.028598128,
-0.009307243,
0.03471277,
-0.021631224,
0.021631224,
-0.013609137,
-0.004058391,
-0.009347827,
-0.0038317975,
-0.017816337,
-0.0016698588,
-0.0155977495,
0.005702039,
0.012486316,
0.033657588,
0.005357076,
0.0014677848,
-0.0016969147,
0.0030995961,
0.000062778236,
0.0069601405,
-0.008076198,
0.011836974,
0.016450012,
0.012019601,
-0.010112157,
-0.0038013596,
0.0041801427,
-0.007602719,
-0.029085135,
-0.015611277,
-0.0010196707,
-0.0107615,
0.017383441,
0.011174103,
0.008299409,
-0.014704904,
-0.0012183628,
0.010409772,
0.0060436204,
-0.0051000444,
-0.0055870516,
0.013128894,
-0.030600268,
-0.007257756,
-0.029166304,
-0.030600268,
-0.029599197,
-0.015421886,
0.025824895,
-0.016504124,
0.021306552,
0.029707422,
-0.0075283153,
-0.001795838,
0.010585637,
0.009591331,
-0.0282464,
0.009226075,
-0.01176257,
-0.0068180966,
-0.023227524,
-0.03649846,
0.019317942,
-0.03330586,
0.005052697,
0.0030082823,
-0.0046130377,
-0.009063739,
-0.041990817,
0.01772164,
-0.0247156,
-0.026541878,
0.009713083,
-0.008657901,
-0.0063987295,
-0.019534389,
0.03373876,
-0.03238596,
0.020319011,
0.0024248885,
0.010233909,
-0.011045587,
0.0043965904,
-0.0071427682,
-0.023213996,
0.023917452,
-0.034225762,
0.000031045634,
-0.023606308,
-0.00016370957,
-0.004051627,
-0.009016392,
0.002736032,
0.005438244,
-0.006669289,
-0.0049647647,
-0.052055627,
-0.002702212,
-0.010937364,
-0.018262759,
0.00074911135,
-0.017951615,
-0.00005210382,
0.023159884,
-0.0044236463,
0.007839458,
-0.04537281,
-0.0022202781,
-0.014853711,
0.003611968,
-0.02865224,
-0.030356765,
0.034820992,
-0.004788901,
0.025337888,
0.04158498,
-0.0077785826,
0.011065879,
0.006713255,
0.019913172,
0.003953549,
-0.013514441,
-0.0012158263,
0.011255271,
-0.025392,
-0.0069330847,
-0.0008340839,
-0.026325429,
-0.009124615,
-0.014069089,
-0.011965489,
-0.007988266,
0.015056631,
0.03996162,
0.004890361,
0.024539737,
-0.020684266,
-0.04924181,
0.012871863,
0.0017670911,
-0.002162784,
0.029599197,
-0.050756942,
0.0013147496,
0.011153811,
-0.017031714,
0.025960173,
0.014312592,
-0.02179356,
-0.0074877315,
-0.011174103,
-0.017586362,
0.012222521,
-0.033468198,
-0.014610208,
-0.005850847,
0.016571764,
0.007677123,
0.007609483,
-0.019426165,
-0.0024130517,
-0.0038419433,
-0.033387028,
-0.007913862,
-0.014542568,
-0.029085135,
-0.030248541,
0.012777167,
0.034144595,
-0.022645822,
0.012154881,
0.009462815,
-0.030464988,
-0.008657901,
-0.013406218,
0.024539737,
0.02412037,
0.016098283,
-0.010680332,
0.01772164,
0.03005915,
0.023958035,
0.0016013734,
0.010118921,
0.0113093825,
0.0037607756,
-0.0041463226,
0.02725886,
-0.0014508747,
0.017180521,
0.021482415,
0.012195465,
-0.007568899,
0.020319011,
-0.0010196707,
0.01272982,
0.014501983,
0.02171239,
0.013602373,
-0.026474237,
-0.0070616,
0.025567863,
-0.022821685,
-0.035010386,
0.0037269557,
0.009970114,
-0.0020444144,
0.0066016493,
0.001125358,
0.003130034,
-0.0074674394,
0.01805984,
-0.006148462,
-0.018844461,
-0.019845532,
0.023876866,
0.010247437,
0.034361042,
0.005326638,
-0.02192884,
-0.0038115054,
0.012608068,
0.026000759,
-0.044263516,
0.035091553,
0.005357076,
0.026717741,
0.012263104,
-0.024336819,
-0.0127162915,
0.01349415,
-0.015475998,
0.0000899927,
-0.005401042,
-0.01938558,
0.06769396,
0.017694585,
-0.009719847,
0.012635124,
-0.045859817,
0.014231424,
-0.0008886185,
0.027529418,
-0.019426165,
-0.022943437,
0.022429373,
-0.019399108,
0.016395899,
-0.019277357,
-0.0014052179,
0.03798654,
-0.023403388,
0.01938558,
-0.024350345,
0.00055971975,
0.017911032,
0.0020562515,
0.021428304,
0.005915105,
-0.01692349,
-0.009111088,
0.015137798,
-0.004917417,
-0.0055329395,
-0.020711321,
0.010572108,
-0.004186907,
-0.027299443,
-0.013920281,
0.0064900434,
0.008502329,
0.0037675395,
-0.0021323462,
0.034956273,
0.0010027607,
0.010917071,
-0.013183007,
-0.0140285045,
-0.032900024,
0.0061789,
0.011119992,
-0.014731959,
-0.014082616,
-0.016422955
] |
Human epithelium contains keratin, which is expressed during differentiation. Depending on the target cell type, different types of keratin are expressed, and their alterations seem to represent changes in cell properties. The basal cells of oral epithelium express keratin 5 (K5), K14, K15 and K19, but their alterations in tumors are unclear. To address this issue and to seek possible diagnostic application, we examined the expression of these keratins in oral squamous cell carcinoma (OSCC) and squamous intraepithelial neoplasm (SIN). cDNA microarray analysis of 43 OSCC | [
0.0030422632,
0.0041334922,
0.01772966,
-0.026253784,
-0.0129211815,
-0.0055123945,
-0.014605435,
0.00085659075,
-0.027616614,
0.0126769,
0.005705248,
0.0028478026,
-0.012702614,
0.019709622,
-0.030727984,
0.012696186,
0.027616614,
-0.00853698,
-0.025328087,
-0.00019235123,
-0.039290678,
-0.006078098,
-0.018912496,
-0.0154668465,
-0.035947885,
0.013602597,
-0.0043231314,
-0.038596403,
-0.018488217,
-0.034199346,
0.016752537,
0.0057245335,
0.0032624376,
-0.002539237,
-0.025829505,
0.026690917,
-0.0043231314,
-0.010639083,
0.016096834,
-0.0035002902,
-0.0070970072,
-0.0072512897,
0.005637749,
-0.023566691,
-0.011294784,
0.010677652,
0.004946691,
-0.01839822,
-0.017716805,
0.020146757,
-0.0015155068,
0.008099845,
-0.01072908,
-0.009147682,
-0.0029024445,
-0.004615626,
0.034045063,
-0.0028285172,
-0.021638157,
-0.0068462975,
0.014116873,
0.0075148563,
-0.0051427586,
0.0051106163,
0.0077527086,
0.007669139,
-0.011545493,
0.019568197,
0.014348297,
-0.0043938444,
0.029468007,
0.0068912967,
-0.018963924,
0.0012929217,
0.023643833,
-0.018706786,
-0.019401057,
-0.011076217,
0.011513351,
-0.0062966654,
0.0047474094,
-0.011989056,
-0.022242432,
0.012124054,
0.021471018,
0.018231079,
0.0077269953,
0.020031046,
0.013576883,
0.008292698,
0.0059045297,
0.021895295,
0.011609778,
0.013268318,
-0.0365393,
0.039830666,
0.0035452894,
0.03882783,
0.0029490506,
-0.027076624,
-0.00023443748,
0.022949561,
0.0004720892,
-0.008633406,
-0.020275326,
0.018475361,
0.028516598,
-0.0034199345,
0.0016794321,
-0.013486885,
-0.017536808,
0.022795279,
0.008929115,
-0.033299364,
0.035973597,
0.0010229269,
0.014451152,
-0.007842707,
-0.030933693,
0.0019333558,
-0.008774832,
0.023669546,
0.0017581807,
-0.039393533,
0.02975086,
0.0059013157,
-0.013294032,
-0.014065445,
-0.014374011,
0.000029279574,
0.016829679,
-0.0003182082,
0.003323508,
0.014361154,
0.0071870056,
-0.021766726,
-0.021676729,
-0.00650559,
-0.0005207043,
-0.02572665,
0.006364164,
0.015659701,
0.004467772,
0.028696595,
-0.005747033,
-0.0018883568,
0.007681996,
0.0024765597,
0.01301118,
0.025083806,
0.027873753,
-0.010349802,
0.029930856,
-0.013474028,
0.013165463,
0.00022399126,
0.02635664,
0.032090813,
-0.017356811,
-0.0039759954,
0.0046188403,
0.004647768,
0.021895295,
0.016045406,
0.0024717385,
0.023643833,
0.024312392,
0.028079463,
0.0015846125,
-0.011114787,
-0.023605263,
0.015453991,
-0.034199346,
0.008806975,
-0.0030133352,
-0.013615454,
-0.0067434423,
0.013551169,
-0.022833848,
-0.030342277,
-0.014091159,
0.044973426,
0.012239766,
-0.005705248,
-0.024093825,
0.0006163275,
0.014952571,
0.0022113863,
-0.01379545,
-0.015942553,
0.0009401606,
0.01218191,
0.013159034,
-0.017305383,
-0.64017063,
-0.05021904,
0.008241271,
0.0011378353,
0.017883943,
0.03139654,
0.02419668,
-0.012226909,
-0.03862212,
-0.017883943,
-0.01636683,
-0.014605435,
-0.00023383481,
0.0016288081,
-0.014682576,
-0.036307875,
-0.018051084,
-0.015531131,
0.027899466,
-0.011288355,
-0.018539645,
-0.0171511,
-0.012001913,
0.025790935,
0.0028510168,
0.027745184,
0.017871087,
-0.031293686,
0.004805265,
0.034405056,
-0.042813465,
0.0117962025,
0.0054159677,
0.0056666774,
0.04988476,
-0.00138292,
-0.019413915,
-0.009906239,
0.004515985,
0.06670158,
0.005351683,
-0.0023142414,
0.0046509826,
0.0020169257,
-0.039419245,
0.020391038,
-0.0018513931,
0.010613369,
0.011693348,
0.0024749527,
-0.016315402,
-0.012606188,
-0.04317346,
-0.0053548976,
0.03178225,
0.0042588473,
0.026048074,
-0.025186662,
0.009096255,
0.013576883,
0.014425438,
0.03342793,
-0.015106854,
-0.013281175,
0.00940482,
0.029339438,
-0.0074184295,
0.008318412,
0.017973943,
0.006994152,
0.0082669845,
0.030547988,
-0.008318412,
0.0059848856,
0.021316735,
0.05042475,
-0.0016537184,
-0.019053921,
0.010600512,
-0.0117962025,
0.015813984,
-0.015441134,
-0.02602236,
0.02257671,
-0.004197777,
-0.012316907,
-0.02589379,
0.014348297,
-0.018218223,
0.004644554,
0.023348125,
0.018051084,
0.0072320043,
-0.027436618,
-0.016456828,
0.008749118,
0.013602597,
0.006576303,
-0.01748538,
-0.026330926,
-0.0013395279,
-0.008903401,
-0.005348469,
-0.00397921,
0.022422427,
-0.006139168,
-0.03612788,
0.0026420923,
0.03322222,
-0.044510577,
0.0025022735,
0.003538861,
0.000823645,
-0.010510514,
-0.0028735164,
-0.01839822,
0.02825946,
0.018951066,
-0.019671053,
-0.034482196,
-0.00021093346,
-0.006724157,
-0.00082444854,
-0.030676557,
0.029390866,
0.0022724564,
-0.016971104,
-0.007579141,
0.016019693,
-0.017061101,
-0.0014391689,
-0.035150755,
0.0074634287,
-0.016058264,
0.0066727293,
0.009989809,
0.035485037,
-0.0023399552,
-0.004805265,
-0.03437934,
-0.021021027,
-0.016482541,
0.011224071,
0.00051708834,
-0.0088262595,
0.008896973,
-0.02568808,
-0.0010060521,
0.010915506,
0.009327679,
0.0002967131,
-0.02009533,
-0.00138292,
0.003526004,
0.020031046,
-0.003898854,
0.0008152076,
0.0018080011,
0.012612616,
-0.003080834,
-0.022692423,
0.012664043,
-0.012619045,
-0.00404028,
0.0130690355,
0.0022997775,
-0.014978285,
0.016045406,
0.02365669,
-0.04127064,
-0.009546246,
-0.0024219179,
0.006540946,
0.006090955,
-0.017382525,
-0.0068591544,
-0.007495571,
-0.0011651563,
-0.009829097,
0.0015420241,
0.0120726265,
-0.025430942,
-0.00412385,
-0.014592578,
0.022460999,
0.021882439,
0.049087632,
0.010658368,
0.012464762,
0.033042226,
-0.008729833,
0.008948401,
-0.021599587,
0.018513931,
0.017421095,
-0.028773736,
0.014592578,
0.0054963236,
0.008749118,
0.023528121,
0.008691262,
-0.013936876,
-0.0030711913,
-0.010844792,
0.022371002,
-0.014669719,
-0.021123882,
-0.00940482,
0.031679396,
0.005624892,
0.0193882,
0.015068283,
-0.027950894,
0.014502579,
-0.012811897,
-0.00061552395,
-0.014361154,
-0.016881106,
-0.013885449,
-0.02121388,
-0.011339783,
0.017176814,
0.013242604,
0.0012109589,
-0.0063320217,
0.020018188,
0.009565531,
0.016353972,
0.01255476,
-0.0034745764,
-0.020172471,
0.0032142242,
0.01806394,
-0.024685241,
0.014219728,
0.025829505,
0.03450791,
-0.013602597,
0.014669719,
-0.010639083,
-0.0006159257,
0.016958248,
-0.0015701485,
-0.00062114885,
0.003182082,
-0.022949561,
0.020018188,
0.012265479,
0.000010590617,
-0.0022419214,
0.011494066,
0.014746861,
-0.02046818,
0.010645511,
-0.005493109,
-0.0046252687,
0.0054159677,
0.029776573,
0.022383858,
0.005766318,
0.015286851,
-0.015363992,
0.015711129,
-0.020763889,
0.0006548982,
0.03360793,
-0.0050077615,
-0.009661958,
-0.030393705,
-0.00072882534,
-0.009134825,
-0.0073477165,
0.022615282,
-0.033659358,
-0.015813984,
0.023540977,
-0.002865481,
0.01690682,
0.005361326,
0.01893821,
-0.02212672,
-0.025096662,
0.017562522,
0.024878096,
0.0024749527,
0.0041784914,
-0.021239594,
-0.01931106,
-0.014746861,
0.013255461,
0.011262641,
0.021946723,
0.0011972985,
-0.013358315,
-0.009796956,
0.006981295,
0.00085096585,
-0.012882611,
0.02671663,
0.01238762,
-0.015993979,
-0.016958248,
0.0054995376,
-0.00062275596,
0.053793255,
-0.0027272692,
-0.003239938,
0.00013580098,
-0.016662538,
-0.030573701,
-0.011121216,
-0.014566864,
-0.03137083,
-0.00026818682,
0.014849716,
-0.002079603,
0.01985105,
0.00071918266,
0.026318068,
0.004001709,
0.00024267392,
-0.024685241,
-0.0140525885,
-0.023103844,
0.011429781,
0.021522446,
-0.0013041715,
0.024878096,
0.03571646,
-0.004287775,
-0.016186833,
-0.016598254,
0.0041656345,
-0.042273477,
-0.01893821,
0.013081892,
0.010285517,
-0.006148811,
0.017575378,
0.0004608394,
-0.0031354758,
-0.010343374,
-0.017498236,
0.022216719,
-0.0059013157,
-0.00845341,
0.028542312,
0.0531247,
0.021779584,
-0.011423353,
0.018153938,
0.020802459,
0.017896801,
-0.011397639,
-0.012169053,
0.028850876,
0.010227662,
0.008710547,
0.009044827,
-0.01616112,
0.006322379,
-0.007566284,
-0.006550589,
-0.010555512,
0.0019413914,
0.014631148,
0.020725317,
-0.009192681,
-0.011577636,
-0.014926857,
0.009848383,
0.015621129,
-0.013268318,
-0.011706205,
0.0063577355,
-0.022602424,
0.0024588816,
-0.009012685,
0.0008023507,
0.019092493,
0.0030486917,
-0.0003784749,
-0.014914,
-0.019015351,
0.0014158657,
-0.014065445,
0.005705248,
-0.013551169,
-0.021908153,
0.007161292,
0.00086944766,
-0.020326754,
-0.026819486,
0.0011603349,
0.03923925,
-0.026073787,
-0.027025197,
0.0037799277,
0.014798288,
0.020378182,
0.0141940145,
-0.015261137,
0.013332602,
0.016868249,
-0.00018080011,
-0.014078302,
0.0015942552,
-0.017305383,
-0.0017003246,
-0.0014946143,
-0.0059141726,
-0.020403896,
-0.017099673,
0.0006524875,
0.007598426,
-0.005232757,
-0.014644005,
-0.01707396,
-0.006782013,
-0.00017115744,
0.024299536,
0.027025197,
-0.0046927673,
-0.01582684,
-0.007508428,
-0.033865068,
0.009025542,
-0.024543816,
0.0028719094,
-0.007771994,
-0.010716223,
0.020416752,
-0.025662366,
-0.0052938275,
0.012702614,
-0.021445304,
0.004512771,
0.00035979223,
-0.00276584,
0.021445304,
-0.02859374,
0.027153766,
-0.0044774143,
0.0045063426,
0.010915506,
-0.016148262,
0.04060208,
-0.0081255585,
-0.0037156432,
0.0100990925,
0.00049458875,
-0.016379686,
-0.00032041798,
-0.015441134,
-0.0023737047,
0.020866744,
-0.0002101299,
-0.031885106,
0.025778078,
-0.0008782868,
-0.004731338,
0.0052616852,
-0.00050141895,
-0.0063834493,
-0.0028044106,
0.021715298,
0.017266812,
-0.013512598,
0.0026886985,
-0.026459495,
-0.012406905,
0.041604917,
0.011429781,
-0.018141082,
-0.010189091,
0.019285345,
-0.006724157,
-0.0025778078,
0.023476694,
-0.018783927,
0.0030535131,
-0.0033588642,
0.042684898,
0.03234795,
0.03571646,
0.0067113,
0.041810628,
0.02671663,
-0.008588407,
0.0066020167,
-0.03749071,
0.008331269,
-0.0164954,
0.0076048546,
0.0010221233,
-0.0071677202,
0.023528121,
0.01114693,
-0.007052008,
0.032913655,
-0.003898854,
0.00015629166,
-0.018539645,
-0.020018188,
-0.034456484,
0.015132568,
-0.022589568,
0.0154668465,
-0.027333762,
0.022550996,
0.017871087,
0.0039245677,
-0.014348297,
-0.009841954,
0.016713966,
-0.012207624,
0.033530787,
-0.0153254215,
-0.016803965,
-0.008556264,
-0.009019113,
0.0034360057,
-0.03687358,
0.007270575,
0.0064895186,
0.02589379,
-0.0049081203,
-0.014978285,
-0.02229386,
0.017755374,
-0.015891125,
-0.025945218,
0.013538312,
0.0013178319,
-0.03319651,
-0.014014018,
-0.030367991,
-0.015723985,
-0.0008573943,
0.019632481,
-0.024170967,
0.023026703,
-0.00005418981,
-0.016109692,
0.037722137,
-0.013949733,
0.03679644,
-0.040499225,
0.035202183,
-0.007829851,
-0.019041065,
-0.016893962,
-0.0005335612,
0.0010422122,
-0.009970523,
0.025572369,
0.032013673,
0.009559103,
0.0024894166,
-0.007868421,
0.008189843,
-0.003323508,
-0.03314508,
0.0045481273,
0.0019735338,
-0.00036461357,
-0.006827012,
0.016649682,
-0.02805375,
0.01358974,
-0.009880525,
-0.027616614,
-0.009006256,
-0.006981295,
-0.04147635,
0.021702442,
-0.004499914,
0.017601091,
0.013120463,
-0.010844792,
-0.029493721,
-0.029108014,
-0.022023864,
0.003270473,
0.008131987,
-0.0055702506,
-0.025919504,
-0.0012374764,
0.031987958,
-0.014078302,
-0.0033138653,
-0.0069877235,
-0.009880525,
0.040524937,
-0.009385535,
-0.0057116766,
0.0055831075,
0.0017099673,
0.014631148,
-0.0035195756,
0.0049659763,
-0.005117045,
-0.05477038,
-0.018501075,
0.026819486,
0.030213708,
0.0038634976,
-0.0113719255,
-0.026086643,
0.003509933,
-0.032476522,
-0.007495571,
0.01097979,
-0.039830666,
-0.022808135,
0.0020249612,
0.011500495,
0.024685241,
0.021059597,
-0.0059302435,
0.0007002991,
0.029828,
-0.0015122925,
0.0061713103,
0.03862212,
0.0036802867,
-0.018693928,
-0.0066920146,
-0.0033363646,
-0.017215384,
0.011564779,
-0.04147635,
-0.01955534,
-0.026870914,
-0.004875978,
0.033633642,
0.0056891767,
-0.005833817,
-0.0072512897,
-0.00006463604,
0.03566503,
0.017408239,
-0.024042398,
0.002724055,
-0.021895295,
-0.024286678,
0.017601091,
-0.00007558449,
-0.013358315,
0.007469857,
-0.019619625,
0.00027903484,
-0.027333762,
0.00803556,
-0.017408239,
-0.014862573,
0.0027979822,
-0.0023576336,
-0.017588235,
0.0066277306,
-0.025790935,
0.019439628,
0.0034327914,
-0.014669719,
-0.032167956,
0.011950485,
0.0055252514,
0.028748022,
-0.014026875,
-0.007257718,
-0.007881278,
-0.037130717,
-0.018295364,
-0.0010655153,
-0.0073091458,
0.025739508,
0.022859562,
-0.005149187,
-0.022885276,
-0.017241098,
-0.045101993,
-0.017498236,
0.005747033,
-0.0013355102,
0.0055123945,
0.0103819445,
-0.012143339,
-0.020262469,
-0.0027995892,
0.009051256,
-0.028722309,
-0.0186425,
0.038724974,
-0.018102512,
0.0151839955,
0.005329184,
-0.00276584,
-0.009019113,
0.019375343,
-0.005203829,
0.0017180028,
0.027616614,
-0.02042961,
0.017459666,
-0.0010028379,
0.044073444,
0.0031001193,
0.039753526,
0.024440961,
-0.016662538,
0.012394048,
0.0010430157,
0.0018610358,
-0.010876935,
0.029982284,
-0.00033709177,
0.0120790545,
0.012895468,
0.008871259,
-0.01819251,
0.0073027173,
-0.016816821,
0.01296618,
0.0042652753,
0.0076177116,
0.02212672,
-0.0057277475,
0.0011362282,
-0.004326346,
-0.0014343476,
-0.03720786,
0.0012744399,
0.012207624,
-0.017665377,
-0.018089654,
0.0022579925,
-0.014824002,
-0.03484219,
0.012406905,
0.0146182915,
-0.02300099,
-0.01616112,
0.010414086,
-0.0044838428,
-0.0038474265,
-0.0063127363,
0.0008967686,
-0.010195519,
-0.019452484,
-0.008299127,
-0.004075636,
-0.0063288077,
0.0058852443,
-0.011320498,
0.0044966997,
0.016212547,
0.009012685,
-0.017125387,
-0.013499741,
0.004660625,
0.18020226,
0.00014303297,
0.0044227727,
0.025803791,
0.0058241743,
-0.007566284,
-0.0073798588,
0.0030342278,
-0.0025247731,
0.009899811,
0.029879428,
-0.0074312864,
-0.008652692,
0.0006440502,
0.039393533,
-0.008363412,
-0.006007385,
0.008633406,
-0.023168128,
-0.01591684,
0.012117625,
-0.03255366,
0.017806802,
0.013409743,
0.027668042,
0.0030663698,
-0.005329184,
-0.016559683,
0.016379686,
-0.0049241916,
-0.020738175,
0.0046413396,
-0.009604102,
-0.010536227,
-0.00795842,
0.0060813124,
-0.006621302,
-0.007148435,
0.0027288764,
0.0057245335,
0.02671663,
-0.018886782,
-0.01785823,
-0.011584064,
-0.0032977941,
0.0064991615,
0.018346792,
0.0050559747,
-0.0037027863,
-0.011140501,
-0.039573528,
0.0026019146,
0.025430942,
-0.0065280893,
-0.0030711913,
0.0013684559,
0.021651015,
0.013859735,
-0.020108188,
0.03260509,
-0.007951991,
0.017356811,
-0.026742345,
0.027128052,
-0.013859735,
0.02962229,
-0.019902477,
0.0054834667,
0.017973943,
-0.037567854,
0.008138415,
0.00013097964,
-0.0033717211,
0.016636824,
-0.0026003073,
-0.024749527,
0.03111369,
0.0021856725,
0.0048920494,
0.022820992,
0.017356811,
0.0056859627,
-0.011172644,
0.028413743,
-0.029493721,
-0.029159442,
0.016791107,
0.029185155,
0.014464009,
-0.024055254,
-0.0058209603,
-0.025649508,
0.011191929,
-0.022808135,
0.026176643,
0.0027272692,
0.0031579754,
0.0146182915,
0.007926277,
-0.0060459557,
-0.01739538,
0.050861884,
0.015235423,
0.003908497,
0.009604102,
0.007932706,
-0.002139066,
-0.0067048715,
0.0062709516,
-0.011731918,
0.029699432,
-0.013602597,
0.0036963578,
-0.0134226,
0.00044517007,
0.0053098984,
0.008427696,
-0.023630977,
0.028516598,
-0.005650606,
-0.0039470675,
-0.01002838,
0.02501952,
0.015981123,
-0.022113863,
0.019478198,
-0.04528199,
0.010819078,
0.013821164,
-0.035305038,
0.015736843,
-0.0232067,
-0.0089676855,
0.02341241,
0.027822325,
-0.012458333,
0.0036449302,
-0.018873924,
-0.009886954,
0.0041656345,
0.005229543,
-0.015119711,
0.0065955883,
-0.008331269,
-0.020352468,
-0.006065241,
0.029648004,
0.0106647955,
-0.006634159,
-0.014515436,
-0.041039214,
-0.03407078,
0.0019413914,
-0.013146177,
0.031422257,
-0.019375343,
-0.015093997,
0.00065610354,
0.008099845,
0.0044259867,
-0.018796783,
0.0052488283,
-0.0028622667,
-0.028490884,
-0.009758385,
-0.012548331,
-0.15952837,
0.012766899,
0.016186833,
-0.033633642,
0.027256621,
0.026073787,
0.0005512395,
0.0018690714,
-0.010857649,
0.024955237,
0.0147597175,
-0.0009915882,
-0.050116185,
-0.03407078,
-0.00044798251,
-0.01772966,
0.009745528,
0.03944496,
0.005104188,
0.004252419,
0.02423525,
-0.0033877923,
0.01321689,
0.014078302,
-0.017292526,
0.0058691734,
0.013924019,
-0.0068462975,
0.00052713277,
-0.025868077,
0.015685415,
0.016958248,
0.028953731,
0.027796611,
-0.00018290945,
-0.01972248,
-0.013846878,
-0.013898306,
-0.023643833,
-0.008067703,
0.026408067,
0.010793365,
0.005837031,
-0.0010012308,
-0.010954076,
0.02084103,
0.007367002,
0.0027063768,
0.02846517,
-0.012310479,
0.02158673,
-0.0019237133,
0.017703947,
0.017022531,
0.011584064,
-0.0074762856,
0.019079635,
0.01247119,
0.021021027,
-0.006164882,
0.0081191305,
-0.009282679,
0.026510922,
-0.0015372027,
-0.009591245,
-0.03551075,
-0.012001913,
0.021741012,
-0.033942208,
0.017768232,
-0.01396259,
-0.01247119,
0.025752364,
-0.013551169,
0.012406905,
0.0053323978,
-0.014515436,
-0.00108239,
-0.02100817,
-0.0071291495,
-0.025662366,
0.018449647,
-0.022563854,
-0.0070134373,
-0.018333934,
0.017986799,
0.0053420407,
0.013731166,
0.003484219,
-0.0082027,
0.006923439,
-0.016713966,
-0.025585225,
-0.0010590869,
0.045924835,
0.017909657,
-0.015505417,
-0.017241098,
-0.021882439,
-0.009436962,
0.027153766,
-0.016058264,
-0.009006256,
0.029262297,
0.01922106,
0.0036770725,
-0.019092493,
0.014181158,
0.061815962,
0.0034777906,
-0.02771947,
-0.017343953,
0.019272488,
0.0065280893,
-0.010086236,
0.019375343,
-0.022512427,
0.018385362,
0.015119711,
-0.0246981,
0.042247765,
0.0029008375,
0.0027594115,
0.016109692,
0.010915506,
-0.03381364,
-0.12085483,
-0.027462332,
-0.0006749871,
0.020905314,
-0.0075212847,
0.02257671,
0.0004427594,
0.032707945,
-0.014811145,
0.035536464,
-0.016469685,
-0.014039732,
0.008594835,
-0.01826965,
-0.0003603949,
0.0120790545,
0.008389126,
0.0061873817,
-0.033762213,
0.019619625,
0.00015086765,
0.0053066844,
-0.020571034,
-0.017716805,
0.0073605734,
-0.006910582,
-0.05183901,
0.014926857,
0.022795279,
0.012008342,
-0.005846674,
-0.01616112,
0.016508255,
-0.00022640191,
-0.0032479735,
0.0034327914,
-0.018796783,
-0.0033010084,
0.034867905,
-0.03029085,
-0.009732671,
0.01739538,
0.000088541834,
-0.008273413,
-0.002151923,
0.014914,
-0.02738519,
-0.006197024,
0.021921009,
-0.02005676,
-0.025225231,
-0.007019866,
-0.022602424,
-0.023219556,
0.020519607,
-0.0132040335,
-0.0002414686,
0.013332602,
-0.007019866,
-0.013294032,
-0.013255461,
-0.0068012984,
-0.0051941862,
0.006004171,
0.030419419,
0.0034360057,
-0.01877107,
-0.009546246,
0.021818154,
-0.00762414,
0.0015179174,
0.009796956,
-0.008794118,
0.009160539,
0.014798288,
0.00050583854,
0.005460967,
-0.0046413396,
-0.010632654,
-0.007964848,
-0.0030069067,
-0.018668214,
0.023836687,
-0.0022772779,
0.027205193,
-0.0048374073,
0.017883943,
-0.007424858,
-0.013435457,
-0.010111949,
0.0005134723,
0.041527778,
0.007064865,
-0.015903981,
-0.004371345,
0.018038226,
-0.007495571,
-0.0016352365,
0.018591072,
0.021715298,
-0.0012704221,
-0.0069620097,
-0.055336084,
-0.0105233705,
-0.01524828,
-0.0035485036,
0.012201196,
0.002151923,
0.012368334,
-0.010195519,
-0.002883159,
0.03749071,
-0.010298374,
0.020622462,
-0.031885106,
0.0005468199,
-0.038982112,
0.010876935,
0.007939134,
-0.00067980844,
0.028696595,
0.047261953,
-0.0035645748,
-0.020571034,
0.0034520768,
-0.021933867,
-0.028670881,
0.006852726,
-0.028825162,
0.012143339,
-0.012599759,
-0.023708118,
0.028156605,
-0.044510577,
-0.00478598,
0.00321101,
-0.011346212,
-0.008806975,
-0.003969567,
0.019593911,
0.018552503,
0.0146182915,
-0.021612443,
-0.04358488,
0.022165291,
0.024672385,
-0.018886782,
0.005708462,
-0.030650843,
-0.006994152,
-0.005505966,
-0.0015283637,
0.039136395,
0.018552503,
0.023258127,
-0.019246774,
0.019786764,
-0.021483874,
-0.0004532056,
-0.006698443,
0.008241271,
-0.011198357,
0.012194767,
0.019799622,
0.010690509,
0.0009232859,
-0.004387416,
0.0011498887,
-0.01996676,
-0.03360793,
-0.016636824,
-0.016623968,
-0.022191005,
-0.009584817,
-0.00038108646,
0.018295364,
0.010279089,
0.0023704905,
-0.0070970072,
0.00019918146,
-0.0044742003,
0.027333762,
0.034250773,
0.011429781,
-0.0072062905,
0.02212672,
0.03666787,
0.001920499,
-0.00164729,
-0.0030197636,
0.011262641,
0.010754794,
-0.0103819445,
0.014425438,
0.0015564881,
-0.006447734,
0.02030104,
0.0006436484,
-0.01897678,
0.015621129,
-0.0056409636,
0.028362315,
-0.011198357,
0.0017035388,
0.003770285,
-0.0025006665,
-0.03687358,
0.016328258,
-0.022640996,
-0.011461924,
-0.024222394,
-0.0010197127,
0.023579549,
-0.016418258,
0.018668214,
-0.00515883,
-0.015723985,
-0.015235423,
-0.009385535,
0.019079635,
-0.017549664,
0.04067922,
-0.0020844245,
0.012580474,
0.0079712765,
0.0010301588,
0.017086815,
-0.008916258,
0.015363992,
-0.0024862024,
0.026459495,
-0.019979618,
-0.0024637028,
-0.021715298,
-0.023939542,
-0.010921934,
-0.019979618,
-0.009308393,
0.013294032,
0.03435363,
-0.022550996,
0.09328964,
-0.0050527607,
-0.037824992,
0.009546246,
-0.0146182915,
0.01951677,
0.0051202592,
0.0077269953,
-0.013936876,
-0.028670881,
0.009070541,
-0.031525113,
0.023888115,
-0.020995313,
-0.0014086338,
0.0074055726,
0.013486885,
-0.00055686437,
0.006396306,
0.0012623866,
0.0104848,
-0.010587655,
0.00093533925,
0.017446809,
-0.03381364,
-0.016096834,
0.020223899,
-0.001562113,
-0.009076969,
-0.042119194,
-0.00028265084,
-0.00329458,
-0.028028036,
-0.004432415,
-0.009559103,
-0.0062998794,
-0.00343922,
-0.028413743,
0.017536808,
0.01951677,
-0.0022146006,
0.008974114,
-0.012490476,
-0.011095502,
-0.011757632,
-0.012066198,
-0.0077012815,
-0.012046913,
0.007019866
] |
BACKGROUND In patients with Ovarian Cancer (OvCa) exosomes released by tumor cells are present in the plasma and could be involved in tumor progression. This study examines the association between the exosome presence/protein content in plasma of OvCa patients and disease outcome, response to standard therapy and/or tumorresistance to therapies in patients studied at diagnosis and also serially during and after therapy. DESIGN AND METHODS Exosomes were purified from OvCa patients' plasma (n=22), patients with benign tumors (n=10) or (n=10) healthy controls (NC) using ultracentrifugation. Ex | [
-0.014436787,
-0.019718211,
0.016554719,
-0.037291683,
-0.019959494,
-0.010321566,
-0.021072078,
-0.011822884,
-0.032439206,
0.013994434,
0.020442061,
-0.0069905147,
-0.009128554,
0.011172759,
-0.012788017,
0.005549517,
0.036728688,
-0.005629945,
-0.018552009,
-0.0036393572,
-0.031742167,
-0.008210336,
-0.014972973,
-0.0113336155,
-0.005335043,
0.0020274504,
-0.002101176,
-0.053189576,
0.025951365,
-0.018779887,
-0.00017059487,
0.020013113,
-0.025428584,
-0.0033796425,
-0.013156645,
-0.00023122987,
0.014222313,
-0.0036259526,
0.019034576,
0.016916644,
0.005928198,
0.003615899,
-0.00770096,
-0.0042492677,
-0.010944881,
0.0027948655,
0.003977824,
-0.011923419,
-0.0026708727,
0.013940816,
0.005013332,
0.006943599,
-0.014825521,
0.00029071292,
-0.01887372,
0.006652048,
-0.0058745793,
0.03592441,
0.000016559432,
-0.024771757,
0.010790728,
0.022895109,
-0.026031792,
0.020401848,
-0.009765273,
0.038578525,
-0.0039208545,
0.027224805,
0.0007594561,
0.0006953652,
0.03777425,
0.03450352,
-0.03372605,
-0.0033444553,
-0.00825055,
-0.021031866,
-0.036406975,
-0.004852476,
-0.015415325,
0.011065522,
0.012211619,
-0.028793147,
0.00013415104,
0.026407123,
0.011628517,
0.035334606,
-0.016809408,
0.009711655,
0.004587735,
-0.01308292,
0.020080136,
0.0054925475,
-0.0031165767,
0.006943599,
-0.016568124,
0.02978509,
-0.007848411,
0.03404776,
-0.0024329405,
-0.049597133,
0.022332115,
0.028176533,
-0.0301068,
-0.023900457,
-0.04970437,
0.010308161,
-0.006698964,
-0.0056198915,
0.02743928,
0.002127985,
-0.009738464,
0.032787725,
-0.018766483,
-0.022828085,
0.011507875,
0.0043699094,
0.0071513704,
-0.020602917,
-0.026983522,
-0.008123206,
-0.0013027625,
0.0011218,
0.02471814,
-0.010154008,
-0.002139714,
0.012204916,
-0.009577609,
-0.0035589293,
-0.0046681627,
-0.00025866748,
0.006843064,
0.033833288,
0.018820101,
0.0030880917,
-0.016434077,
-0.012111084,
-0.03375286,
-0.017010476,
-0.0107237045,
-0.032466017,
0.0008574775,
0.024396427,
0.005583029,
0.009396646,
-0.044101235,
0.0077076624,
0.024476856,
0.013397928,
0.02249297,
0.030696604,
0.01884691,
-0.011702242,
0.017560067,
-0.018431367,
-0.0026524414,
-0.01227194,
0.019905876,
0.0248924,
-0.018565413,
-0.01572363,
0.00015520048,
0.017332187,
0.019959494,
0.013565486,
0.016836217,
0.020187374,
0.01270759,
0.007057538,
0.00007000778,
-0.009664739,
-0.026809262,
0.026876284,
-0.032385588,
0.017358996,
-0.012392581,
0.015683418,
-0.0077679832,
0.026608191,
-0.051929537,
-0.042170968,
-0.019610975,
0.037559774,
0.023779815,
-0.010469017,
-0.013739746,
-0.013324203,
0.018645842,
-0.023055965,
0.008284062,
-0.020643132,
-0.002136363,
0.024007693,
-0.0062800692,
-0.001460267,
-0.6232617,
-0.029624233,
0.0011176111,
0.0040213894,
0.022064023,
0.030455321,
0.01508021,
-0.00056634564,
-0.022787873,
0.0059047397,
-0.0353078,
0.026179243,
-0.0060924045,
-0.011809479,
0.0008562208,
-0.044878703,
-0.013505165,
-0.018806696,
0.02938295,
0.006826308,
-0.028551864,
-0.0017560066,
0.007459677,
0.02701033,
0.0011737429,
0.030535748,
0.018779887,
-0.029999563,
-0.01415529,
0.020723559,
-0.008592368,
0.020857606,
-0.0155627765,
0.006936896,
0.04203692,
0.005696968,
0.010301459,
0.009068233,
-0.0026088762,
0.041500736,
0.013478356,
-0.010636575,
0.013545379,
0.00014231948,
-0.059302084,
0.011655326,
0.00509376,
-0.007633937,
0.0018129763,
-0.002263707,
0.022131044,
0.010127199,
-0.031098744,
-0.0098322965,
-0.0049898736,
0.01152128,
0.03957047,
-0.03624612,
0.0065180017,
0.00039417992,
0.014919354,
0.031474072,
-0.0057908003,
-0.02975828,
-0.0057740444,
0.026849475,
-0.016983667,
0.006286772,
0.019356286,
0.012158,
0.017895183,
0.02938295,
0.01224513,
0.01195693,
0.026795857,
0.04536127,
0.011923419,
0.0071982867,
-0.0038571826,
0.012459604,
0.025750296,
-0.001988912,
-0.032010257,
0.021058675,
0.0148389265,
-0.0029523699,
-0.03123279,
0.035039704,
0.031179171,
0.020750368,
0.018994361,
0.00077118515,
-0.00024777622,
-0.0214206,
-0.0011595006,
0.007714365,
-0.011910014,
0.003917503,
0.014195504,
-0.019128408,
-0.010019962,
0.0026273075,
-0.014007839,
-0.0013798391,
0.022734253,
0.014798712,
-0.052412104,
0.012566841,
0.036487404,
-0.043243337,
0.008123206,
0.006950301,
0.007164775,
-0.034610756,
0.0073256306,
-0.019436715,
-0.009215684,
0.017305378,
-0.004145382,
-0.037184447,
0.0010472367,
0.0039476636,
0.011467662,
-0.011186164,
0.017452829,
0.020884415,
0.010355077,
-0.034181807,
-0.022358924,
-0.028471434,
0.009141958,
-0.016514504,
-0.0014116751,
-0.008518643,
0.0089744,
-0.0144233825,
-0.010542742,
-0.0038136174,
-0.0013396252,
-0.0425463,
-0.023726197,
-0.0105561465,
0.0034986085,
0.0032841344,
-0.008263955,
0.0072787143,
-0.005103813,
-0.0016135824,
-0.0048156134,
0.0017291973,
0.008920781,
-0.018900529,
-0.0026557925,
0.010026664,
0.027479492,
-0.004272726,
-0.0019637784,
-0.018632436,
-0.008156718,
-0.0179488,
0.006725773,
0.00013436048,
-0.01635365,
-0.0042157564,
0.0019185378,
-0.034020953,
-0.004564277,
0.017452829,
-0.005381959,
-0.021179317,
-0.0007707663,
-0.014275932,
-0.0020592865,
0.025870938,
0.010046771,
-0.005254615,
0.0026708727,
0.00092156837,
0.0050066295,
-0.010435505,
0.012540032,
-0.023109583,
-0.021232935,
0.0071245614,
0.028042488,
0.026728833,
0.041071787,
0.020093542,
0.02176912,
0.012023954,
-0.041205835,
-0.002350837,
-0.024557283,
0.02446345,
0.019530546,
-0.0370504,
0.0014292687,
0.014731689,
0.023096178,
0.009028018,
0.022224877,
-0.018686054,
0.0044335816,
-0.0042626727,
0.02231871,
-0.009208981,
0.013766556,
-0.007654044,
0.019503737,
0.021554645,
0.010066878,
0.0008930835,
-0.022533184,
0.0019352935,
-0.011923419,
0.005629945,
0.018069442,
-0.0140614575,
-0.004658109,
-0.024530474,
-0.030911079,
0.0016378782,
0.037184447,
-0.0075132954,
-0.0063202833,
0.011186164,
0.00833768,
0.036058456,
0.01487914,
-0.0046648113,
0.0076808534,
0.025133682,
-0.004912797,
-0.014195504,
0.031286407,
-0.0118698,
0.025106873,
-0.012901957,
0.03959728,
-0.010830942,
-0.01432955,
0.0067023155,
-0.0026993575,
-0.00091402826,
-0.00089224573,
-0.022828085,
0.028230151,
0.028980812,
-0.0032992146,
-0.00022599369,
0.008545452,
0.0048558274,
-0.009396646,
0.0027546515,
-0.0049429573,
-0.016045343,
-0.00081977696,
0.0053886613,
0.04176883,
0.002463101,
0.027988868,
-0.012774613,
0.0046044905,
-0.01195693,
-0.011105737,
0.013371119,
0.017707517,
-0.012318855,
-0.0048122625,
0.009128554,
0.0060253814,
-0.023069369,
0.014262527,
-0.011152653,
0.00081181794,
0.03343115,
0.007654044,
0.0050233854,
0.015039995,
0.004011336,
-0.040428367,
-0.029302523,
0.009825594,
0.018954149,
-0.0122250235,
-0.021541242,
-0.021058675,
0.0069637056,
-0.010743812,
0.00035857386,
0.021728907,
0.010254542,
-0.03260006,
-0.010676788,
-0.0032372184,
0.004162138,
-0.010462314,
-0.007948946,
0.04249268,
-0.01299579,
0.0025485554,
-0.018082846,
-0.0024513719,
0.012345665,
0.033270292,
0.028498245,
0.009249195,
-0.014463596,
0.00028505785,
-0.024235573,
-0.005700319,
-0.015241065,
-0.01670217,
-0.012741101,
-0.0032003555,
0.0014862384,
0.02501304,
-0.0023206766,
0.04249268,
0.020495681,
-0.01916862,
-0.03225154,
-0.009912725,
-0.031420454,
0.020093542,
0.023458103,
0.007774686,
0.004292833,
0.017962204,
0.017787945,
-0.020013113,
-0.002127985,
0.015348302,
0.00053450966,
-0.022412542,
0.019543951,
0.009577609,
0.0021799281,
-0.020214183,
0.02688969,
-0.014034648,
-0.023645768,
-0.009564204,
-0.008069588,
0.0034449901,
-0.0120574655,
0.032117493,
0.01525447,
0.027962059,
-0.010743812,
0.00033469687,
0.030240847,
0.01508021,
0.017184736,
-0.0024714787,
0.02561625,
0.0015490727,
0.009229088,
-0.011903312,
-0.01343144,
0.014048053,
0.013558784,
0.008444917,
0.010107092,
0.01630003,
0.027345447,
0.0056433496,
-0.0021950083,
-0.0017057393,
-0.01597832,
0.010897964,
-0.0014962918,
0.012788017,
-0.02833739,
0.031366836,
0.004654758,
0.002064313,
-0.021434003,
0.00880014,
0.014436787,
-0.00005560827,
-0.013237073,
-0.008056183,
0.0022553292,
-0.0023139743,
-0.005060248,
-0.005237859,
-0.010053473,
0.00208442,
-0.022104235,
-0.020817392,
-0.023055965,
-0.020911224,
-0.0021346875,
0.01887372,
-0.022224877,
-0.01902117,
-0.00038894374,
0.02906124,
0.015241065,
-0.006799499,
-0.023578744,
-0.005271371,
0.020884415,
-0.0083577875,
-0.010180817,
-0.016420672,
-0.042144157,
0.0047452394,
-0.01369283,
-0.0034449901,
0.0072385008,
-0.0057371818,
-0.0013178427,
-0.0045173606,
-0.012104382,
-0.010851049,
0.0094435625,
0.01143415,
0.0060722977,
0.005971763,
0.0018381099,
-0.014436787,
-0.0020509085,
0.011192867,
-0.046648115,
-0.01172235,
-0.0040247403,
-0.020281207,
-0.0073658447,
-0.0073859515,
0.010964988,
-0.0013681101,
-0.007962351,
0.016072152,
-0.013397928,
-0.010663384,
-0.017586876,
-0.0008704632,
0.02249297,
-0.01760028,
0.012298749,
0.008297467,
0.00978538,
-0.003910801,
0.009389943,
0.023364272,
-0.02119272,
0.005740533,
0.013216966,
0.0026122273,
-0.0061594276,
-0.008786735,
-0.026635,
-0.0033561843,
0.019919282,
-0.033511575,
-0.032573253,
-0.0402407,
-0.0046011396,
-0.0038437778,
0.0010933152,
0.010810834,
-0.014544024,
-0.012278642,
0.031634927,
-0.010542742,
-0.010978392,
0.015790654,
-0.034691185,
-0.007928839,
0.019155217,
0.009678143,
-0.020066733,
0.011916717,
0.003282459,
-0.04310929,
-0.016393863,
-0.013411333,
-0.036004838,
-0.015133828,
0.008605773,
0.025562631,
0.030455321,
0.027197996,
-0.000005439086,
0.028364198,
-0.0023190011,
0.0015381813,
0.009939534,
0.010730407,
0.0065146503,
0.001547397,
0.009483776,
0.0116419215,
-0.0042626727,
0.038632147,
-0.034664374,
0.006709018,
0.027801204,
-0.009168767,
-0.0030395,
0.0017895182,
-0.04788134,
-0.02741247,
-0.002883671,
-0.002657468,
0.023806624,
-0.02943657,
0.009202279,
0.0010313188,
0.020053327,
-0.003803564,
-0.029302523,
0.027720775,
-0.009765273,
-0.0034382876,
-0.007674151,
-0.029114857,
0.0077210674,
-0.0115011735,
0.00020274504,
-0.005482494,
0.0053450963,
0.0002693493,
0.0251873,
0.035012893,
-0.0032606763,
-0.017037285,
-0.0064543295,
-0.01395422,
-0.001157825,
0.0012097679,
-0.02341789,
-0.016541313,
0.007835006,
-0.010013259,
-0.031340025,
-0.030696604,
0.010448909,
-0.014999782,
0.010355077,
-0.0014912651,
-0.018176679,
0.027265018,
-0.0022553292,
0.007835006,
-0.01172235,
0.031045124,
0.022171259,
-0.020562703,
-0.00025992416,
-0.022479566,
-0.002538502,
0.0037331895,
0.03412819,
0.03514694,
-0.014048053,
-0.017828159,
-0.005009981,
0.013940816,
-0.008759926,
-0.021849548,
0.028471434,
0.014235717,
0.008639284,
-0.018069442,
-0.018954149,
-0.027050545,
0.018833507,
-0.01597832,
-0.014544024,
0.0036125479,
-0.013216966,
0.0075870208,
0.015375111,
-0.008686201,
0.010288054,
0.004336398,
-0.017332187,
-0.024905805,
-0.016407268,
0.0047686975,
-0.0032841344,
-0.0032590008,
0.030696604,
-0.014932758,
0.0063437414,
0.011487768,
-0.0011075576,
-0.029597424,
-0.0019872366,
0.01595151,
0.043002054,
0.003178573,
0.0048223156,
0.047747295,
0.008015969,
0.0037901592,
-0.009215684,
-0.0061091604,
0.0030830652,
-0.039007474,
-0.007312226,
0.03458395,
0.016447483,
-0.008780033,
-0.008290764,
-0.025669867,
0.0062834206,
-0.049114566,
-0.0098054875,
-0.005887984,
-0.030616175,
-0.018243702,
-0.00037281628,
0.028819956,
0.033377532,
0.01595151,
-0.010985095,
-0.0060722977,
0.02608541,
-0.008699605,
0.00023479048,
0.0109985,
-0.012285344,
-0.028578673,
0.009101744,
-0.026514359,
-0.011266592,
0.008505238,
-0.024503665,
-0.03230516,
-0.017613685,
-0.03806915,
0.020535894,
0.02032142,
-0.011574899,
0.024946017,
0.01652791,
0.012982384,
-0.005378608,
-0.0077478765,
0.034315854,
-0.00833768,
-0.021849548,
0.0033344019,
-0.015039995,
-0.015160637,
0.010308161,
0.0063068788,
-0.003465097,
0.006799499,
0.003508662,
-0.00914866,
-0.0014594292,
0.006249909,
-0.0020123702,
-0.01227194,
-0.024047907,
-0.016889835,
0.0015398569,
0.01351857,
-0.006095756,
-0.021206126,
-0.009758571,
0.020602917,
0.02119272,
-0.033511575,
-0.00017132793,
-0.018015824,
-0.015442135,
-0.0272114,
0.001380677,
-0.022774467,
0.00044444727,
0.02014716,
-0.021165911,
-0.0073457374,
-0.009865808,
-0.036219314,
0.0054858453,
-0.010395291,
0.01062317,
0.009316218,
0.025348157,
-0.002669197,
0.021849548,
-0.002947343,
0.00509376,
-0.003468448,
-0.019195432,
0.011950228,
-0.038283624,
0.029409759,
0.0042258096,
-0.04898052,
-0.013424737,
0.016259817,
0.016286626,
-0.012540032,
0.010375184,
-0.004269375,
0.009906022,
-0.02741247,
0.01887372,
-0.025374966,
0.0120574655,
0.0051239203,
-0.02686288,
-0.010676788,
0.0066218874,
0.0046011396,
0.011849693,
0.006943599,
-0.002020748,
0.007272012,
-0.0028233503,
0.009664739,
-0.011460959,
0.014262527,
-0.009477074,
-0.015696822,
0.03916833,
-0.0026641702,
0.01207087,
0.021366982,
0.0013144916,
-0.0036058456,
0.0060756486,
0.004852476,
0.0017392508,
-0.00097602466,
-0.009021317,
-0.02943657,
0.0064710854,
-0.006950301,
-0.028739529,
0.004524063,
0.011789372,
0.0024698032,
-0.02254659,
0.029195286,
0.043028865,
-0.025790509,
-0.014852331,
-0.0017962205,
-0.0025988228,
-0.011326913,
-0.0085521545,
-0.017171333,
-0.009604418,
-0.008210336,
-0.015147232,
-0.0020492328,
0.015039995,
-0.00016944291,
-0.023538532,
-0.017238354,
-0.007292119,
0.17672665,
-0.01884691,
-0.016742384,
0.02394067,
0.015938105,
-0.016568124,
0.016715575,
-0.020710154,
-0.0038002129,
0.013438142,
0.016836217,
-0.003135008,
0.01814987,
-0.009135256,
0.006776041,
-0.0060722977,
-0.017358996,
-0.008156718,
-0.0043665585,
0.0061527253,
-0.009812189,
-0.015643204,
0.021661883,
-0.010006556,
0.01904798,
-0.024235573,
-0.00862588,
-0.0015700173,
0.010288054,
0.014798712,
-0.013418036,
0.006997217,
0.0074060583,
0.0063873064,
0.019610975,
0.024972826,
0.010442208,
-0.0041990005,
-0.010261245,
-0.013779961,
-0.0016847946,
0.0027998923,
-0.014758498,
0.013491761,
-0.020790583,
0.0120306555,
-0.006903385,
-0.0140614575,
-0.0012273615,
-0.010924774,
-0.047774103,
0.017291974,
0.0037130828,
0.016916644,
-0.023350867,
0.027479492,
0.027801204,
0.00052152394,
-0.019155217,
0.026286481,
-0.006085702,
0.013739746,
-0.025321348,
0.03804234,
-0.014972973,
0.001082424,
0.004527414,
-0.009242493,
0.0118698,
0.008806842,
0.010261245,
-0.0009048126,
0.0107103,
0.00021415993,
-0.006819606,
-0.0033729402,
0.032063875,
0.0056433496,
0.00018033417,
0.003166844,
0.01684962,
0.0072519053,
-0.023525126,
-0.0007255256,
-0.034289043,
-0.04581703,
0.004865881,
-0.00296745,
-0.01722495,
0.0044536884,
0.0053652036,
-0.017171333,
-0.015522562,
-0.0109180715,
0.018230299,
0.007332333,
0.00012640147,
0.018203488,
-0.024905805,
0.00046245975,
-0.022586802,
0.063698806,
0.010107092,
0.01572363,
0.0033042415,
-0.012473009,
-0.040562414,
0.008505238,
0.025106873,
0.0013521921,
0.020763773,
-0.016326841,
0.0051406757,
-0.0156298,
-0.0018113008,
0.020589512,
-0.01178267,
-0.01007358,
0.05989189,
-0.019664593,
-0.010267947,
-0.03479842,
0.017787945,
0.027774395,
0.002836755,
0.013424737,
-0.019905876,
0.0058745793,
-0.0012508195,
-0.015120423,
0.0027144377,
-0.012144595,
-0.018163275,
0.0036695176,
0.029275713,
-0.038578525,
-0.0012072546,
0.0056198915,
-0.0008101424,
-0.0136995325,
-0.008364489,
0.0017007125,
-0.0025167195,
0.047640055,
-0.011876503,
-0.008257252,
0.02032142,
0.019155217,
-0.010167412,
-0.027425874,
-0.046138737,
-0.0431361,
-0.020857606,
-0.012935469,
0.036835924,
-0.011025309,
-0.013860388,
-0.028149724,
-0.0049429573,
0.005777396,
-0.024677925,
0.009208981,
0.0111124385,
-0.016367054,
0.0020743667,
-0.00021866303,
-0.16836216,
0.01565661,
0.0017291973,
-0.023873648,
0.029168475,
0.0012952224,
0.007855114,
-0.008572261,
-0.010113793,
0.013116431,
0.021313362,
0.00039857833,
-0.037801057,
-0.009557501,
0.011715647,
0.012901957,
0.0030462022,
0.03016042,
0.04426209,
0.029624233,
0.013491761,
-0.017144522,
0.025669867,
-0.014624452,
0.005683563,
0.005167485,
0.0065448107,
-0.010294756,
-0.02069675,
0.0018247054,
-0.0009399997,
0.006273367,
-0.00046999985,
-0.0066218874,
0.0071915844,
0.00063085544,
-0.0026072008,
-0.012714292,
0.005743884,
0.01125989,
0.016916644,
0.016742384,
0.00005812164,
0.008739819,
-0.005204348,
0.023029156,
-0.008143313,
-0.008558856,
0.026836071,
-0.0068966825,
0.021795928,
-0.008297467,
0.008042779,
-0.0028987513,
-0.023659173,
0.023699386,
0.034744803,
0.009664739,
0.03627293,
0.0059449538,
-0.001125989,
-0.01597832,
0.0098322965,
0.005690266,
0.005237859,
-0.023645768,
0.007292119,
0.026675215,
-0.016005129,
-0.0040884125,
-0.025535822,
-0.013585594,
0.024584092,
-0.0031567905,
0.015857678,
0.0030696604,
0.004269375,
0.023645768,
-0.0023005698,
-0.013277287,
-0.017211545,
0.0026273075,
-0.007868518,
-0.012164703,
-0.012365771,
0.005170836,
0.0033159705,
0.028122915,
-0.0017660601,
-0.022667231,
0.011300104,
-0.028766338,
-0.014771903,
-0.006504597,
0.014302741,
0.045254033,
-0.015683418,
-0.008565559,
0.0020106947,
-0.020160565,
0.021715501,
-0.019812044,
-0.009356433,
-0.0054020663,
0.032090686,
-0.01667536,
0.0016487696,
-0.00028317282,
0.039999418,
-0.033967335,
-0.0205493,
-0.0033411041,
0.010562849,
0.013062812,
0.0024647764,
0.036192503,
0.030428512,
-0.0031450614,
0.0050568967,
-0.014302741,
0.0668623,
-0.0017358997,
-0.0031199278,
0.017627088,
0.00038873428,
-0.02254659,
-0.11581601,
-0.020348229,
0.014611048,
0.030374892,
-0.017439425,
0.022090832,
-0.009731762,
0.048685618,
-0.024262382,
0.05074993,
-0.009456967,
0.00882695,
0.003803564,
-0.016179388,
0.028578673,
-0.0050703017,
-0.0035388225,
-0.001162014,
-0.016997071,
0.01487914,
-0.007881923,
0.00059231714,
0.009845701,
-0.00038852484,
0.004289482,
0.0053082337,
-0.024114931,
0.009369837,
0.025817318,
0.005100462,
0.015683418,
0.013391226,
0.0051909434,
-0.036782306,
-0.01974502,
0.0041520842,
-0.0022100885,
-0.030214038,
0.030777032,
-0.018900529,
-0.006943599,
-0.011099034,
0.008263955,
0.021366982,
-0.0024932614,
-0.003699678,
-0.04675535,
-0.0030445268,
0.02526773,
-0.030937888,
-0.039758135,
-0.029945945,
-0.010784025,
-0.012023954,
0.0046279486,
-0.023257034,
0.0006911763,
0.017506447,
-0.009919426,
-0.0057371818,
-0.0022921918,
0.0046882695,
-0.0094703715,
0.014289336,
0.012620459,
-0.027640348,
-0.0026038494,
-0.0064342227,
-0.0006677182,
-0.020039923,
-0.014249123,
-0.012774613,
-0.0068296595,
-0.011715647,
-0.023297248,
0.00036841788,
0.020053327,
-0.015844272,
0.008391298,
-0.042599916,
-0.0072519053,
-0.013216966,
0.0063236346,
-0.008069588,
0.03302901,
0.01812306,
0.009792083,
-0.0021749013,
-0.011206271,
-0.0015289657,
0.007895327,
0.036085267,
-0.015670013,
-0.053216383,
-0.019262454,
-0.009195576,
-0.01757347,
-0.008672796,
0.024061311,
0.028149724,
-0.006950301,
-0.02124634,
-0.05887314,
0.013377821,
0.01198374,
-0.015294683,
-0.00425597,
-0.024329405,
0.018927338,
-0.0014250798,
0.00047921555,
0.011943526,
-0.0036594642,
0.01369283,
-0.02943657,
-0.0012441173,
-0.0055361125,
0.020254398,
0.023337461,
-0.015884487,
-0.0028233503,
0.05812248,
-0.008632582,
-0.001794545,
0.02087101,
-0.005422173,
-0.0057070213,
0.021755716,
0.0185252,
0.051500592,
-0.037157636,
-0.010683491,
-0.014342954,
-0.030750223,
-0.0068397126,
0.007948946,
-0.015348302,
-0.0018364344,
-0.013297394,
0.013397928,
0.0033025658,
0.011615112,
-0.018069442,
-0.04782772,
0.01869946,
-0.0021950083,
-0.018163275,
0.026326694,
-0.016621742,
0.014074862,
-0.022278497,
0.00039208544,
0.013873792,
0.016715575,
0.023364272,
-0.01814987,
-0.0011050443,
-0.00288032,
-0.0065213526,
0.011548089,
-0.0068765753,
0.00042077975,
0.030214038,
0.020897819,
-0.0075132954,
0.018163275,
0.012935469,
-0.005566273,
-0.02159486,
-0.02272085,
0.01268078,
0.0013597322,
0.0052144015,
-0.00028484841,
-0.007627235,
0.0013873792,
-0.00055252213,
0.009798785,
-0.016728979,
0.018686054,
0.0006497057,
0.025951365,
0.006648697,
0.026474146,
-0.016259817,
0.03152769,
0.03268049,
0.015737036,
0.0024832077,
0.016072152,
0.00535515,
0.029892325,
-0.031634927,
0.02471814,
0.022412542,
0.0067023155,
-0.0013538677,
0.011065522,
-0.011527983,
0.001456078,
0.010804133,
0.031045124,
-0.0057908003,
0.018230299,
0.010844346,
-0.03340434,
-0.013940816,
0.007734472,
-0.04136669,
-0.03458395,
-0.02301575,
0.019128408,
0.017694112,
0.005127271,
0.013900602,
-0.0033008903,
-0.021353576,
-0.0020475574,
0.029141666,
-0.0029054538,
-0.010569551,
0.026702024,
0.009141958,
0.008116504,
0.0023357568,
-0.0029976105,
0.020763773,
-0.00613597,
0.022265092,
-0.014517215,
0.008277359,
-0.028015679,
0.023525126,
-0.030214038,
-0.022627017,
0.0014259176,
-0.00034307476,
-0.02686288,
0.0049865227,
-0.007332333,
0.0009240817,
0.07940903,
0.014383169,
-0.012117786,
0.0039979313,
-0.0016956858,
0.02735885,
0.015683418,
0.016608337,
-0.0048993924,
-0.021326767,
-0.011119141,
-0.01050923,
0.036433786,
-0.03083065,
-0.01994609,
0.044020806,
0.008699605,
0.006588376,
-0.022962132,
0.0083309775,
0.004758644,
-0.0039845263,
-0.0024781812,
0.012888553,
-0.004061603,
0.010636575,
0.030374892,
0.0006848928,
-0.0257637,
-0.0155627765,
0.0007531727,
-0.0140882665,
-0.032492824,
-0.018002419,
0.013940816,
-0.010643276,
-0.011246485,
-0.036460597,
0.011910014,
0.0176539,
-0.01924905,
0.015790654,
-0.03922195,
-0.015039995,
-0.017814754,
-0.028766338,
-0.0063001765,
-0.00050937594,
-0.018980958
] |
OBJECTIVE To measure the impact on transmission of leishmaniasis of curtains impregnated with insecticide. DESIGN Cluster randomised controlled trial: household interview survey, observational study of people's behaviour, entomological study with light trap captures of sandflies inside houses. SETTING 14 urban sectors in Trujillo, Venezuela. PARTICIPANTS 2913 inhabitants of 569 houses. INTERVENTION Sectors were paired according to their 12 month cumulative incidence of cutaneous leishmaniasis, one sector in each pair was randomly allocated to receive polyester curtains impregnated with lambdacyhalothrin (int | [
-0.004509288,
0.011213027,
0.020733781,
-0.014762672,
0.017005278,
0.025466641,
-0.0050871368,
0.00522472,
-0.010077965,
-0.014955288,
-0.013118553,
0.021229079,
0.02351296,
0.02554919,
0.0005120673,
0.030103194,
0.031093791,
-0.007979822,
-0.0012193307,
-0.01787205,
-0.032717273,
-0.0017189295,
-0.005689063,
0.0069273114,
-0.0028789274,
0.0022443251,
0.021669345,
-0.02016969,
-0.024957582,
0.011887184,
-0.0061706044,
-0.008702134,
-0.02612704,
-0.0072506317,
-0.026498515,
-0.033350155,
0.0075051608,
-0.0056030736,
0.019000232,
0.002710388,
0.009046092,
0.01069709,
-0.014054119,
-0.009362533,
0.021407938,
0.015313004,
0.005296951,
0.008984179,
-0.028163271,
0.021573037,
0.011680809,
0.02556295,
-0.011274939,
0.015175421,
-0.011880305,
-0.012272417,
0.0073538194,
0.001159138,
0.005737217,
-0.034588404,
-0.012967212,
0.009947262,
-0.032937404,
-0.002978675,
-0.018931441,
0.015959645,
-0.012974091,
0.0058954377,
-0.012313692,
0.02685623,
0.053629912,
0.045677606,
0.0069823447,
-0.02138042,
0.020788813,
0.007821602,
-0.0076221065,
-0.005241918,
0.015409312,
0.014473747,
0.020045865,
0.007567073,
-0.044136673,
0.010098603,
0.022384778,
0.009108004,
0.011804634,
0.042403128,
-0.0066315075,
0.005737217,
-0.013104795,
0.019564323,
0.0025263706,
0.015120388,
-0.013400598,
0.013263015,
-0.0012554462,
0.025439125,
0.0011789156,
-0.025232749,
-0.018408624,
-0.017927084,
-0.024379734,
-0.010972256,
-0.008495759,
-0.009369412,
0.0035634036,
-0.016496219,
0.024998859,
-0.022027062,
-0.024049534,
0.0243247,
0.0073194234,
-0.038743414,
0.0099541405,
-0.009052971,
0.010160515,
0.0045849583,
-0.01983949,
-0.019743182,
0.0022271273,
0.006425133,
0.015808303,
-0.011536347,
0.021421697,
0.012107317,
-0.02938776,
-0.009018576,
-0.008055493,
-0.008103647,
-0.02351296,
0.03304747,
0.025893148,
-0.017610643,
0.009995416,
0.013476269,
-0.033955522,
-0.010036691,
-0.036211886,
-0.011852788,
0.0025332498,
0.02113277,
-0.009981657,
-0.025673015,
0.004392342,
0.043889023,
0.024517316,
0.023870677,
-0.020912638,
0.0033828258,
0.0025831235,
-0.029855544,
0.020348547,
0.009479479,
0.014377439,
0.02220592,
0.021751896,
0.023196518,
-0.03169916,
-0.0017120503,
-0.017583126,
-0.0030096313,
0.013263015,
0.008729651,
0.020458614,
0.029938092,
0.008750288,
-0.01028434,
0.006211879,
-0.0150103215,
-0.0013999086,
0.03387297,
-0.02554919,
0.034643438,
-0.01387526,
0.011694567,
0.00571314,
-0.00011834301,
-0.003780097,
-0.016716352,
-0.0375602,
0.034423303,
0.011385006,
0.022935111,
0.0005903177,
-0.01633112,
0.009341896,
0.016620044,
0.008426968,
-0.03290989,
0.011274939,
0.004206605,
-0.0025607664,
-0.035441417,
-0.6454301,
-0.017005278,
0.0069685862,
-0.0037697782,
0.0056237113,
0.004564321,
0.02587939,
-0.01069709,
-0.009596424,
0.031038757,
0.010353132,
0.0045368043,
0.0060949335,
-0.0347535,
-0.005788811,
-0.017693194,
-0.027007572,
0.0036528325,
0.013909657,
-0.004915158,
-0.016702594,
0.021490488,
0.008303143,
0.033432703,
0.011219906,
0.008825959,
0.032854855,
-0.022577394,
0.005764734,
0.0045918375,
-0.019302916,
0.026072007,
-0.020926397,
0.03486357,
0.05877552,
-0.02963541,
0.004382023,
0.0060364604,
0.018491175,
0.03329512,
-0.01787205,
-0.038495764,
0.034230687,
-0.0014119471,
-0.018064667,
0.011047927,
0.0052522365,
-0.008702134,
0.015973404,
-0.013620731,
0.0017481658,
0.0060708565,
-0.017748225,
0.00905985,
0.032469623,
-0.0021101816,
0.019977072,
-0.027392805,
0.019330433,
0.007484523,
-0.009286863,
-0.011955976,
0.003314034,
-0.01639991,
-0.01853245,
0.013517545,
0.0069582677,
0.0039520757,
-0.016922727,
-0.017252928,
0.00726439,
0.031038757,
-0.016840177,
0.00082979834,
0.014088514,
0.018216008,
0.02922266,
0.0028617296,
-0.018105943,
-0.006132769,
-0.0072024777,
-0.0059229545,
-0.025975699,
0.015560654,
0.01117863,
-0.027076364,
0.013820227,
-0.010958497,
-0.005771613,
0.006328825,
0.010050449,
0.02612704,
-0.0184499,
0.0036115577,
-0.007855997,
0.027736763,
-0.002031071,
0.009947262,
-0.000050384453,
-0.026718648,
-0.0018900485,
-0.025741806,
0.0027619817,
-0.011405643,
0.026140798,
0.010208669,
0.0042169234,
0.02400826,
0.028314611,
-0.01527173,
-0.008619584,
0.014267372,
-0.021985788,
-0.011164873,
0.024063293,
-0.032717273,
0.01044944,
-0.018064667,
0.0011617177,
-0.037119932,
-0.0017352675,
0.013111674,
0.022095853,
-0.012932816,
0.0057784924,
0.013950931,
-0.023980742,
-0.020142173,
0.002228847,
-0.01763816,
0.0074501275,
0.008791563,
0.00905985,
-0.011089202,
0.026883747,
0.009321258,
0.035386387,
-0.013483148,
0.005809448,
-0.0182848,
-0.02083009,
-0.00881908,
0.008557672,
-0.0017361273,
0.0034584964,
-0.04300849,
-0.00220477,
0.0041928464,
-0.010298098,
-0.012877783,
-0.007209357,
-0.0357441,
0.0038729657,
0.014969046,
-0.0066108704,
0.0014755792,
-0.020678747,
-0.014391197,
-0.006545518,
-0.008825959,
0.0130084865,
0.013648248,
-0.0032607205,
0.0011359209,
-0.010463199,
-0.011323093,
0.013909657,
-0.00089773006,
0.0047156624,
-0.04113736,
0.034313235,
-0.016055953,
-0.021861963,
0.033762906,
0.0017447263,
0.020142173,
-0.0041997256,
-0.031864256,
0.0017731028,
0.012877783,
0.0037835366,
0.021366663,
-0.0014308648,
-0.004302913,
0.01992204,
-0.009231829,
0.020995189,
0.022192162,
0.01869755,
0.030350842,
0.020362306,
0.0006109552,
0.0044198586,
0.012100438,
-0.033377673,
0.014982805,
0.027970653,
0.0099059865,
-0.002808416,
0.018890167,
0.039734013,
-0.00579569,
0.034313235,
-0.011577622,
0.008750288,
-0.015739512,
0.007463886,
-0.006129329,
0.035138737,
-0.0032435227,
0.015436829,
-0.024462285,
-0.011722084,
0.0007008142,
-0.004034626,
0.027447838,
-0.014955288,
0.0019571204,
-0.0070580156,
0.00800046,
-0.017431784,
-0.013235499,
0.022893837,
0.004230682,
-0.016771385,
0.005296951,
-0.0017765424,
0.013421236,
0.0033019956,
-0.010827794,
-0.022976385,
-0.00905985,
0.004440496,
0.017899567,
0.01608347,
0.007904151,
0.010587024,
-0.016950244,
0.038165566,
0.021201564,
0.031809222,
0.026223348,
0.00017240888,
-0.0024369415,
0.02162807,
0.006456089,
0.023650544,
0.019523049,
0.0057097008,
0.0052384785,
0.015134146,
0.017761985,
-0.044604458,
-0.005437974,
0.0068069263,
-0.022109611,
-0.0035255682,
0.0044542546,
0.025934424,
0.034313235,
0.008626464,
-0.008681497,
0.026305897,
-0.010807157,
0.006624629,
-0.0030199501,
-0.022494845,
-0.0004505848,
-0.014487506,
-0.010717727,
0.002547008,
-0.0055755572,
0.023210278,
-0.011385006,
0.009706491,
0.0014128069,
0.022164645,
0.0097340075,
0.01143316,
-0.0016234812,
-0.034010556,
-0.0025298102,
0.017899567,
0.017211651,
0.0003259001,
-0.03315754,
-0.0020035545,
0.0054998863,
-0.023251552,
-0.0020276317,
0.026085764,
0.0023492323,
0.0071543236,
-0.010483836,
-0.003680349,
-0.028452195,
0.024971342,
-0.023127727,
0.016317362,
-0.0022150886,
-0.0019605597,
-0.016620044,
-0.018312316,
-0.024696175,
0.017032793,
0.0067862887,
-0.027860587,
-0.018752582,
-0.004588398,
0.013366203,
0.008248109,
-0.009355654,
-0.011109839,
0.01477643,
0.0004587538,
0.0020362306,
-0.009362533,
0.0024335019,
0.025645498,
-0.00093298574,
-0.026663614,
-0.033928003,
-0.011254301,
-0.0031850499,
0.05087825,
0.024242152,
0.0008874113,
0.031231375,
0.035881683,
-0.031891774,
-0.008709013,
-0.025906907,
0.004433617,
-0.0052556763,
-0.009011696,
0.004725981,
0.02678744,
0.009782162,
-0.0035152494,
0.006793168,
-0.005568678,
-0.014914013,
0.0121279545,
-0.0028858066,
-0.00013210133,
-0.0027327454,
0.020045865,
0.022549879,
0.004825729,
-0.010793398,
0.006624629,
0.020032106,
0.024847517,
-0.0056718653,
-0.009706491,
-0.004670948,
0.028369645,
0.031066274,
-0.019619357,
-0.025700532,
-0.012148592,
-0.018972715,
0.01469388,
-0.011481314,
0.007064895,
0.018009635,
-0.01159138,
-0.0069582677,
0.00783536,
-0.007986702,
0.012795233,
0.024462285,
-0.034313235,
0.002980395,
0.031974323,
-0.0069513884,
0.0009673815,
-0.012671408,
-0.0024025457,
-0.011536347,
-0.0037904158,
0.0015151345,
-0.0019691589,
-0.018931441,
-0.0053072697,
-0.03648705,
0.02015593,
-0.012011008,
-0.03445082,
-0.019908281,
-0.02212337,
0.005537722,
-0.028424678,
0.00025667856,
-0.0032194457,
-0.026072007,
-0.018807616,
0.018491175,
0.0094175665,
-0.00077046565,
0.01739051,
-0.0055239634,
0.004760377,
0.018174734,
-0.03780785,
-0.011261181,
0.017528092,
-0.021683104,
0.026952539,
0.013730798,
0.0135450605,
-0.0041102967,
-0.024365975,
-0.0045712,
0.0021514564,
0.011206147,
0.007333182,
-0.002335474,
-0.004849806,
0.008970421,
-0.009231829,
0.018559966,
-0.0004604736,
-0.03332264,
0.02164183,
-0.015065354,
0.006211879,
-0.014721396,
0.0070786527,
-0.019867007,
-0.013916535,
-0.005764734,
-0.020857606,
0.013084157,
0.02563174,
-0.021091497,
-0.0067862887,
-0.008853476,
0.027805554,
0.024998859,
-0.02702133,
0.017665677,
0.02205458,
0.006153406,
0.0028840867,
0.02212337,
0.015780788,
0.026759923,
-0.030626008,
-0.00053528446,
0.0011410803,
-0.005561799,
-0.023471685,
-0.01150883,
-0.007567073,
0.03332264,
0.018436141,
-0.025342816,
-0.016372394,
-0.016922727,
-0.0045677605,
-0.004873883,
-0.015588171,
-0.0039967904,
-0.009011696,
-0.030708559,
-0.02220592,
-0.0071543236,
0.02376061,
-0.027695488,
-0.012210504,
0.026237106,
-0.01682642,
0.017129103,
-0.009286863,
-0.020059623,
-0.018931441,
-0.0030354282,
-0.012176109,
-0.0246549,
-0.0067484532,
-0.010373769,
0.04964,
0.02384316,
0.037917916,
-0.0041997256,
-0.007732173,
-0.009396929,
0.0026880307,
0.0091424,
0.027241463,
0.013889018,
-0.011900942,
0.01583582,
0.01755561,
-0.014432472,
0.0077528106,
-0.011453797,
0.009775283,
0.022412295,
-0.021050222,
-0.010518231,
-0.005558359,
-0.0058335257,
-0.0075395564,
0.018229768,
-0.009782162,
0.01281587,
-0.028314611,
-0.0010559506,
0.023719335,
0.00023733093,
0.006597112,
0.0116395345,
0.034891088,
-0.017706951,
0.008495759,
-0.0056684255,
-0.009052971,
-0.0145700555,
-0.0028892462,
-0.012416879,
-0.007821602,
0.0033914247,
-0.004891081,
-0.005413897,
-0.015959645,
-0.004278836,
0.0043717045,
0.008426968,
0.019220365,
0.015822062,
0.0038248114,
-0.01159138,
-0.020114657,
-0.020431098,
-0.02056868,
-0.041329976,
-0.0015030958,
0.014102273,
0.00015424361,
0.017046552,
-0.016798902,
-0.01363449,
-0.0014377439,
-0.005785371,
0.032854855,
-0.03698235,
0.01379959,
0.015945887,
-0.017404268,
-0.02685623,
0.0017645039,
-0.0135450605,
-0.016028436,
0.027172672,
0.03681725,
-0.019536806,
-0.0063700997,
0.02538409,
0.016537495,
-0.015794545,
-0.026085764,
0.013490028,
0.0056546675,
-0.015092871,
-0.019481774,
-0.010442561,
-0.037174966,
0.022770012,
-0.021174047,
-0.0032056873,
0.0031334562,
-0.00041833875,
0.003324353,
0.002978675,
-0.018009635,
0.027654212,
0.0025366894,
-0.006621189,
0.0024558592,
-0.022921352,
-0.018092183,
-0.003566843,
-0.011068564,
0.020197205,
-0.0011170032,
-0.010896585,
0.007821602,
0.03651457,
-0.008206835,
0.0041240547,
-0.018986475,
0.031368956,
-0.009438204,
0.005362303,
0.012176109,
-0.0032521216,
0.017913327,
-0.021201564,
-0.0005752695,
-0.022797527,
-0.0013053201,
-0.019701907,
0.017362993,
0.029415278,
0.006727816,
0.019880764,
-0.025851874,
0.0121279545,
0.004382023,
-0.031754192,
0.015202938,
-0.0026880307,
-0.0020121536,
0.01615226,
-0.008688375,
0.0056546675,
0.01836735,
0.0015968244,
0.0019158453,
0.01616602,
-0.031479023,
-0.0107590025,
0.008674618,
-0.009582667,
-0.015051597,
0.023884434,
-0.0068791574,
-0.017583126,
0.012251779,
-0.020940155,
-0.03835818,
-0.014762672,
-0.00060794555,
0.0138615025,
-0.0041928464,
-0.035689067,
0.021820687,
0.017995875,
0.02180693,
-0.026567306,
0.011598259,
0.039321262,
-0.018408624,
-0.0069066742,
0.027365288,
-0.013675765,
0.0103462525,
-0.016620044,
0.014143548,
0.011254301,
-0.03599175,
-0.011481314,
0.0045987167,
0.0090254545,
-0.012286175,
-0.027213946,
0.006002065,
-0.023609268,
-0.0025298102,
-0.0019210047,
-0.009073609,
-0.016441187,
-0.020389823,
-0.022082096,
-0.029140111,
-0.0058748005,
0.003680349,
0.021421697,
-0.011481314,
-0.04066958,
-0.030488426,
-0.01714286,
-0.031479023,
0.039706495,
0.0066108704,
-0.0054998863,
-0.00084140693,
0.0026811515,
-0.04303601,
0.016193537,
0.002294199,
-0.009355654,
0.0120798005,
-0.008963542,
0.016207295,
0.023705576,
0.0077528106,
0.015368038,
-0.008509518,
-0.019701907,
0.01249255,
-0.0142536145,
0.032689758,
0.000055463206,
-0.042568225,
-0.0070511363,
0.006383858,
0.015285487,
0.0038110532,
0.009823437,
-0.01722541,
-0.001902087,
0.0107590025,
0.012141713,
-0.008358176,
-0.037009865,
-0.011378126,
-0.017294202,
-0.012100438,
-0.004206605,
0.004302913,
-0.012829629,
-0.02205458,
0.009582667,
-0.018174734,
-0.00922495,
-0.032469623,
-0.016358636,
0.0013723919,
-0.025095167,
0.014556297,
0.0063941767,
0.014391197,
0.01339372,
0.0053038304,
-0.01714286,
-0.028727362,
0.016771385,
-0.00514561,
-0.015244213,
0.015601929,
0.007388215,
0.018601242,
-0.01265765,
-0.003468815,
-0.013152949,
0.026072007,
-0.024022017,
-0.017321719,
-0.0036700305,
0.013359324,
0.012808991,
-0.0062737917,
-0.0064216936,
-0.014054119,
0.0030251094,
-0.00906673,
-0.0062497146,
0.011398763,
-0.035166252,
0.016675077,
0.0066383868,
-0.021036463,
0.041495077,
-0.005486128,
0.00019078913,
-0.022494845,
0.00538638,
0.18832381,
-0.0022271273,
0.015202938,
0.030488426,
-0.016551252,
0.031121308,
0.035386387,
0.0041481317,
-0.011157993,
0.03723,
0.018174734,
-0.023540476,
0.004891081,
0.008433847,
0.00041210453,
-0.002514332,
-0.007897273,
-0.008825959,
0.008729651,
-0.0022185282,
0.01232745,
-0.006432012,
0.006965147,
-0.009596424,
0.03502867,
0.0069307513,
-0.007739052,
0.0069789053,
-0.0071268072,
0.0037835366,
-0.0067484532,
-0.0050424226,
0.0015108349,
0.014515022,
0.01502408,
-0.0006380418,
-0.0004841207,
-0.014680122,
0.014652605,
0.0031472144,
0.03255217,
-0.0076221065,
-0.033983037,
-0.027626697,
-0.029662926,
0.013950931,
0.0076289857,
0.0026673933,
0.0041034175,
-0.005640909,
-0.007071774,
-0.014597572,
0.013324928,
-0.0016475582,
-0.013152949,
-0.02107774,
0.03780785,
0.01029122,
0.008199955,
0.028837427,
-0.013579457,
0.02000459,
-0.007787206,
0.016234811,
-0.015037838,
0.020554923,
-0.004946114,
0.009789041,
-0.012595737,
-0.016675077,
-0.0062875496,
-0.02180693,
-0.014817705,
0.021696862,
-0.0060123834,
-0.011440039,
-0.00416533,
0.0017326878,
0.019825732,
0.012795233,
0.004189407,
-0.025617981,
-0.013840864,
0.0040999777,
-0.030020643,
-0.028699845,
0.010084845,
0.0065042432,
-0.009506996,
0.00010383228,
-0.0000011773167,
-0.0046984646,
-0.021586796,
-0.01289842,
0.037119932,
0.0017868611,
0.018312316,
-0.0020465492,
-0.0028772075,
0.007849119,
-0.031644125,
0.0493098,
0.022315986,
-0.0016647561,
0.0010439121,
0.029497826,
-0.011997251,
0.004849806,
-0.0044680126,
-0.011446918,
0.027984412,
-0.033102505,
0.012100438,
-0.0013904497,
0.012643891,
0.00014177513,
0.0057750526,
-0.014652605,
0.012045405,
0.013902777,
-0.0032590008,
-0.008371934,
-0.008681497,
0.022095853,
-0.01502408,
-0.03390049,
-0.030460909,
0.01664756,
-0.019798215,
-0.013840864,
-0.014088514,
-0.014556297,
-0.0046915854,
-0.018271042,
-0.0016879733,
-0.008667738,
-0.010600782,
-0.0025126121,
-0.0107108485,
0.009114884,
0.0015538296,
-0.025150198,
0.0017275284,
-0.009011696,
-0.0072231153,
0.001984637,
0.014803947,
0.021270355,
-0.024613624,
-0.014556297,
-0.023499202,
-0.026938781,
0.006325385,
-0.020265998,
0.02114653,
-0.024448525,
-0.010545748,
-0.030323327,
0.022178404,
0.0024300623,
-0.015808303,
0.0029975928,
0.018271042,
0.014459989,
0.010999773,
-0.005052741,
-0.1765467,
0.004498969,
0.030983726,
-0.018683791,
0.021972029,
0.020224722,
0.020059623,
0.017087827,
-0.021999545,
-0.008846597,
0.0037525804,
0.008688375,
-0.05307958,
-0.022756252,
-0.0074914023,
0.0070580156,
-0.025439125,
0.037257515,
0.035221286,
0.01706031,
0.030460909,
-0.016234811,
0.011357489,
-0.010373769,
0.0035771618,
0.02113277,
-0.0008882712,
0.0054826885,
0.0059883064,
-0.046172906,
0.00040114086,
0.023925709,
0.02758542,
-0.0038316906,
0.008853476,
0.006301308,
0.0026639537,
0.021050222,
-0.01265765,
0.0077115353,
0.0141573055,
0.021985788,
-0.0258106,
0.026869988,
-0.008846597,
0.026030732,
0.006325385,
-0.012891541,
0.0020792254,
-0.008041735,
0.0006423413,
-0.010648936,
0.008482001,
-0.0012090119,
0.008199955,
-0.00040393553,
0.013159828,
-0.0054173362,
0.009974779,
0.010889706,
-0.012086679,
-0.022192162,
0.013964689,
0.0013448753,
0.003649393,
-0.014047239,
0.0008220593,
0.0030147908,
-0.0071749613,
0.010731486,
-0.037037384,
0.014652605,
-0.0018332954,
-0.016358636,
0.010951619,
0.028919978,
0.0047397395,
0.021586796,
0.008248109,
-0.0056237113,
-0.021036463,
0.023320343,
-0.034010556,
0.007911031,
-0.003396584,
0.011866546,
-0.0056374697,
0.020720022,
0.0021772534,
-0.0016862535,
0.023444168,
-0.009610183,
-0.00922495,
-0.035221286,
0.012134833,
0.027365288,
0.009376291,
-0.0020603077,
0.008715892,
-0.0008525856,
0.02083009,
-0.038330667,
-0.017858293,
0.027172672,
-0.019977072,
-0.0067862887,
-0.024365975,
-0.0064388914,
0.026649855,
-0.009623941,
-0.011350609,
0.01232745,
0.0070064217,
0.008784684,
-0.0028015368,
-0.0023320343,
0.020761296,
-0.01583582,
0.012719562,
-0.011281818,
0.044054125,
-0.012602616,
-0.008103647,
0.009520754,
-0.020995189,
-0.015491863,
-0.12745702,
0.0037869762,
0.0040449444,
-0.0005984867,
-0.0001250072,
0.02563174,
-0.011742721,
0.014556297,
0.024476042,
0.007518919,
-0.03304747,
0.0038110532,
-0.025686774,
-0.004333869,
0.01289842,
0.0011556984,
0.01339372,
-0.017445544,
-0.014886497,
0.032029357,
0.0049598725,
-0.022659944,
-0.0076771397,
-0.0009845794,
0.0011961135,
0.0113712475,
-0.0099541405,
0.007849119,
-0.01298097,
0.005076818,
0.012953454,
-0.002636437,
0.0019691589,
-0.0044198586,
-0.030350842,
-0.026429722,
-0.019619357,
0.0029872742,
0.019894524,
-0.03357029,
-0.010497594,
-0.0053760614,
0.012396242,
0.014914013,
0.009527633,
0.016427428,
-0.010057328,
0.016798902,
-0.00068318634,
-0.022013303,
-0.025604224,
-0.026842471,
0.0004007109,
-0.010243066,
0.016950244,
-0.015409312,
0.0011935338,
0.01494153,
-0.04190783,
-0.0142536145,
-0.008475122,
0.025769323,
-0.013909657,
0.02106398,
0.0071474444,
-0.0032280446,
-0.04498969,
-0.019908281,
0.012423758,
-0.02083009,
-0.016207295,
-0.0017361273,
-0.021215321,
0.013531303,
-0.0380555,
0.0010602501,
-0.02905756,
-0.018670034,
0.0027516629,
-0.012017888,
-0.009857832,
-0.009218071,
0.02775052,
-0.0015624287,
0.014267372,
0.0018866089,
0.0027654213,
-0.0067140576,
-0.017693194,
0.012052284,
-0.00046821265,
0.018105943,
0.0043063527,
-0.015533137,
-0.011543226,
0.0063460227,
-0.012705804,
-0.017734468,
0.03461592,
0.027654212,
-0.051483613,
-0.02000459,
-0.067470774,
0.0029872742,
0.006229077,
-0.011763359,
0.017252928,
-0.021091497,
0.024145842,
0.019330433,
0.0048876414,
0.005166247,
-0.021256596,
0.033845454,
-0.03233204,
0.01298097,
-0.016922727,
-0.008440726,
0.021738138,
0.02384316,
0.022398537,
0.019385466,
-0.008365056,
-0.015780788,
-0.0042238026,
0.012925937,
-0.02938776,
0.020596197,
0.022687461,
0.02433846,
-0.007656502,
-0.008557672,
0.009396929,
-0.011660172,
-0.011343731,
0.0024283426,
-0.010951619,
-0.0380555,
-0.0033088748,
0.035303835,
0.028892461,
-0.0023303146,
-0.004457694,
-0.025728049,
0.020692505,
0.00022013304,
-0.0012907019,
0.021421697,
0.006180923,
0.0016191817,
0.013290532,
-0.0009493237,
0.020472372,
0.013600094,
-0.010889706,
-0.005854163,
0.00587824,
-0.021889478,
0.001567588,
-0.007959185,
0.011632655,
-0.0038970427,
0.035551485,
0.010628298,
0.015519379,
0.010917223,
0.0053347866,
-0.01510663,
-0.007849119,
-0.01747306,
0.008378814,
-0.009011696,
-0.01591837,
-0.029690443,
-0.012526945,
-0.0064044953,
-0.014886497,
0.015863337,
-0.009775283,
0.015904611,
0.008633343,
0.026622338,
-0.009513875,
-0.007013301,
-0.016358636,
-0.006115571,
0.029993126,
0.0041687693,
-0.009513875,
0.0056202714,
-0.014184822,
-0.0152304545,
-0.012822749,
0.01591837,
-0.00071715214,
-0.029360244,
-0.0071818405,
0.019013992,
0.022770012,
0.005362303,
0.003986472,
0.0498051,
0.00146956,
0.01494153,
-0.012602616,
-0.028232062,
-0.006669343,
0.0077665686,
-0.0027052287,
-0.019082783,
-0.003111099,
0.016798902,
0.012045405,
-0.021119013,
0.0065627163,
-0.008709013,
0.009912866,
0.008922267,
-0.019867007,
-0.007608348,
-0.040366895,
0.026622338,
-0.018229768,
0.036432017,
0.0031970884,
-0.0028496908,
0.004660629,
0.012533825,
0.024200875,
-0.011137356,
0.040201794,
0.007931668,
0.0039279987,
0.009114884,
-0.022907594,
-0.014102273,
0.0022254074,
-0.032992437,
0.028892461,
0.002098143,
0.010483836,
0.08106399,
0.0147901885,
-0.008234351,
0.00375602,
-0.008110527,
-0.0016131625,
0.0074019735,
0.0069789053,
-0.014969046,
-0.026801197,
0.0098028,
0.008922267,
0.02612704,
-0.043696407,
-0.04446687,
-0.0048291683,
-0.034010556,
0.0253153,
-0.027805554,
0.005706261,
0.038770933,
0.0043957816,
0.014088514,
0.007787206,
-0.020637473,
-0.006490485,
0.002294199,
-0.015257971,
-0.017817019,
-0.03332264,
-0.014349923,
0.0070167407,
-0.013428115,
-0.024531076,
0.008509518,
-0.0027413443,
-0.022164645,
-0.026925022,
-0.00057354977,
0.0059298337,
-0.0018401745,
0.025851874,
-0.026347173,
-0.011770238,
-0.004440496,
0.010490715,
-0.01657877,
-0.005764734,
-0.022095853
] |
Pancreatic ductal adenocarcinoma (PDA), one of the deadliest human cancers, often involves somatic activation of K-Ras oncogenes. We report that selective expression of an endogenous K-Ras(G12V) oncogene in embryonic cells of acinar/centroacinar lineage results in pancreatic intraepithelial neoplasias (PanINs) and invasive PDA, suggesting that PDA originates by differentiation of acinar/centroacinar cells or their precursors into ductal-like cells. Surprisingly, adult mice become refractory to K-Ras(G12V)- | [
-0.009178244,
-0.0134727135,
0.0055137197,
-0.01643278,
-0.02307092,
0.013106938,
-0.03273009,
0.0019050782,
-0.04205058,
0.022569673,
0.018573243,
0.028313696,
0.024804965,
0.014752925,
-0.010776816,
0.01478002,
0.033055224,
-0.01624312,
-0.006191081,
-0.014901945,
-0.020998195,
-0.0053951815,
0.0067329695,
-0.035276968,
-0.008886978,
0.017679125,
0.012869862,
-0.03262171,
-0.005276643,
-0.027243465,
0.011555781,
0.0027094446,
0.0038135431,
-0.0018187147,
-0.0034782495,
0.030670913,
-0.0029058794,
-0.020456307,
0.012571823,
0.0010744641,
-0.007579671,
-0.0074441987,
0.002988856,
-0.009137602,
-0.008473787,
0.013736884,
-0.013127259,
-0.031835973,
-0.01643278,
0.01809909,
0.0040709404,
0.017381087,
-0.014319414,
0.000117691496,
-0.015890893,
-0.012673427,
-0.0018644365,
0.02233937,
-0.0018762903,
-0.0057643433,
0.0037254863,
-0.011874141,
-0.025062362,
0.025983574,
0.0028025818,
0.022569673,
-0.0056288713,
0.018071996,
0.017719768,
0.009557566,
0.05502882,
0.024832059,
-0.015972177,
-0.0011405068,
-0.009801416,
-0.00689215,
-0.01965702,
-0.011007119,
-0.0021421546,
0.0020947393,
0.015674137,
-0.039097287,
-0.013113712,
0.028801396,
0.031727597,
-0.0066686203,
-0.018356487,
0.012456671,
0.0033597113,
0.010106228,
0.008507656,
0.036875542,
0.009381452,
0.013838488,
-0.0068582813,
-0.00035095774,
0.011623518,
0.009774322,
0.004690726,
-0.047306903,
-0.014454886,
0.019209962,
-0.0028533838,
-0.019480906,
-0.00843992,
0.019142225,
-0.0013115405,
0.008270579,
0.016365046,
0.009320489,
-0.02019891,
0.040939707,
0.02258322,
-0.017936522,
0.04028944,
-0.012883409,
0.027243465,
0.0068447343,
0.0033512441,
-0.019833134,
0.005422276,
0.016527612,
0.006465412,
-0.01667663,
0.02931619,
0.006380742,
-0.0154709285,
-0.004812651,
-0.00024533173,
-0.004094648,
0.018939018,
-0.0027314587,
0.033001035,
-0.0019135452,
-0.012680201,
0.013357562,
-0.033190697,
-0.004009978,
-0.017272709,
-0.048119735,
-0.0020422437,
0.021512989,
-0.005208907,
-0.0010346691,
-0.017922975,
0.007349368,
0.018627431,
-0.007958993,
0.0053376057,
0.013533676,
0.018640978,
-0.005232615,
-0.0077625588,
-0.022190351,
0.017028859,
0.006990367,
0.0023555234,
0.017028859,
-0.012639559,
-0.014129753,
0.0028279827,
0.014576811,
-0.02980389,
0.027351843,
0.022041332,
0.031917255,
0.020280192,
0.031619217,
-0.009936888,
-0.023924395,
0.0077490113,
0.017516559,
-0.03248624,
0.013594639,
0.002047324,
-0.006048835,
-0.026037762,
0.008514429,
-0.02736539,
-0.002971922,
-0.004846519,
0.014400698,
-0.0014029843,
0.01873581,
-0.0045383195,
-0.0108106835,
0.012707295,
0.003711939,
-0.008846336,
-0.018654525,
0.012470218,
0.016500518,
0.0028889452,
-0.007159707,
-0.6346603,
-0.033570018,
0.027649881,
-0.010925835,
0.0033783386,
0.03877215,
0.009279848,
-0.019589284,
-0.023382507,
-0.003039658,
-0.016378593,
0.015010322,
0.009557566,
-0.008223164,
-0.01687984,
-0.024994627,
-0.006949725,
-0.009882699,
0.024886249,
-0.0014614067,
0.006804093,
0.00016044993,
-0.014888397,
-0.00006471974,
0.0014233051,
0.01780105,
0.015958628,
-0.0086905435,
0.018071996,
0.025848102,
-0.020998195,
0.01697467,
0.009862378,
-0.016378593,
0.05118141,
-0.009191791,
-0.0021929566,
0.027243465,
0.019291244,
0.059065893,
0.005435823,
0.016554706,
0.0068955366,
0.005635645,
-0.03327198,
0.0055679088,
0.0027670204,
0.0032631874,
0.006390902,
-0.010411041,
0.00086702226,
0.001803474,
-0.028205318,
0.00055458944,
0.010607475,
-0.022623861,
0.01127129,
-0.03419319,
0.0023606035,
0.00034587755,
0.024588209,
0.036550406,
-0.0072545377,
-0.01697467,
0.009401772,
0.016026365,
0.015836703,
0.011488045,
-0.028638829,
0.007024235,
0.02755505,
0.023396054,
-0.0026163075,
0.01956219,
0.0270809,
0.038799245,
0.006749904,
0.023179298,
-0.020510495,
-0.00078065874,
0.021445254,
-0.0024351133,
-0.0399914,
0.02931619,
0.022230992,
0.004514612,
-0.02355862,
0.015321909,
0.009286622,
0.006478959,
0.011359346,
0.0058151456,
-0.025197834,
-0.03053544,
0.0032936686,
-0.006970046,
-0.0039286944,
0.019819587,
-0.021946501,
-0.025387496,
-0.01965702,
0.008710864,
-0.005859174,
-0.024601758,
0.043757528,
-0.0012971465,
-0.041291934,
0.0089208465,
0.035547912,
-0.029722607,
-0.007247764,
-0.012951145,
0.01251086,
-0.0068210266,
0.0035629196,
-0.017245615,
0.004724594,
0.011616743,
-0.00020479591,
-0.016378593,
0.013926545,
-0.0021573952,
-0.013791073,
-0.028232412,
0.0052495487,
-0.00648912,
0.006919244,
-0.010715853,
0.018397128,
-0.00512085,
0.005632258,
-0.021580726,
-0.017977165,
-0.020496948,
0.0026332415,
0.009388225,
0.010458456,
0.012443124,
-0.013628506,
-0.024710134,
-0.018193921,
-0.0070513296,
0.011345799,
0.020740798,
-0.0058862683,
-0.0050463406,
-0.020226004,
-0.0026975907,
0.00075102417,
0.020889817,
0.00037657045,
-0.010546513,
0.010573608,
0.020564685,
0.039639175,
-0.01487485,
0.013696242,
0.0019677342,
0.0045078383,
-0.009713359,
0.00081241,
0.006289298,
-0.011420309,
0.00038228568,
-0.014197489,
-0.012957918,
0.012930824,
0.014509075,
0.013885903,
-0.036035612,
-0.014820661,
-0.0054663043,
0.008548298,
0.009550792,
0.014901945,
-0.008385731,
-0.015281267,
-0.023111561,
-0.00714616,
0.010038492,
0.008663449,
-0.020645967,
0.0089208465,
0.003207305,
0.05722347,
0.00795222,
0.019101584,
0.012063802,
-0.002799195,
0.028367884,
-0.024588209,
0.00997753,
-0.009747227,
0.03180888,
0.014021375,
-0.014807114,
0.005022633,
0.036604594,
-0.0035121175,
0.037986413,
0.008555071,
-0.014116206,
0.0153490035,
-0.006516214,
0.02190586,
-0.03492474,
0.0020016022,
-0.020253098,
0.029289097,
-0.013513355,
-0.003606948,
0.02376183,
-0.005632258,
-0.0016315937,
-0.010228153,
0.017909428,
-0.011670932,
-0.022190351,
0.00045044516,
-0.020524042,
-0.027595693,
0.0067871585,
0.011555781,
-0.0051716524,
0.013411751,
0.008995356,
0.009645622,
0.03449123,
0.009306942,
-0.030968951,
-0.014373603,
0.019196415,
-0.02053759,
0.01594508,
0.0010262021,
0.0049074814,
0.0073967837,
0.010675211,
0.025631346,
-0.0025045427,
0.009367905,
-0.0026163075,
-0.006089477,
0.016961124,
0.0047144336,
-0.00951015,
0.019616378,
0.013493034,
-0.03674007,
0.008582165,
-0.0021573952,
0.023436695,
-0.016757915,
0.022122614,
0.010268795,
-0.016961124,
0.015050964,
0.007356142,
0.035981424,
0.0044367155,
0.008616034,
-0.02160782,
0.025739724,
-0.012314426,
-0.012185727,
0.0045247725,
0.026850596,
0.0030887667,
0.01307307,
0.007227443,
0.0024385,
-0.029397473,
0.016012818,
-0.051208504,
-0.009239206,
0.014197489,
0.0040573934,
-0.013845262,
0.012199274,
0.010356852,
0.010519419,
-0.036143992,
0.028936869,
0.014861303,
-0.008487335,
-0.017679125,
-0.023572167,
-0.0044942913,
-0.0011676013,
0.012768257,
0.008981809,
0.025834555,
-0.0023690707,
0.00900213,
-0.02351798,
-0.036171086,
0.00027094447,
-0.008358637,
0.021729745,
0.0012903729,
-0.0067024883,
-0.004429942,
0.0071529336,
-0.0021370745,
0.029099435,
0.018789997,
-0.002311495,
-0.02278643,
-0.0006680474,
-0.025346855,
-0.013723337,
-0.020090532,
-0.028909773,
-0.014481981,
-0.009842058,
-0.0055882293,
0.018600337,
-0.0061775334,
0.0370652,
0.005490012,
-0.012842767,
-0.016608896,
0.012402482,
-0.0044130078,
0.025373949,
0.016757915,
-0.03546663,
0.0012725922,
0.00041446034,
-0.000022596345,
-0.013303373,
-0.021201404,
0.029262,
-0.0077151433,
-0.012185727,
0.009625302,
0.010681985,
-0.0020371636,
0.029262,
0.01354045,
-0.023572167,
-0.03351583,
-0.031537935,
-0.009794642,
-0.008074145,
-0.0057643433,
0.032702997,
0.019047394,
0.019724756,
-0.010201058,
0.010370399,
0.023084467,
0.01736754,
0.00004289072,
-0.0005774504,
0.02545523,
0.004267375,
0.005649192,
0.010648117,
-0.03877215,
0.021756839,
0.01828875,
-0.009801416,
0.014129753,
0.024886249,
0.0068108663,
0.013452392,
-0.011806404,
0.0068616685,
-0.012896956,
-0.013994281,
0.0046602446,
0.0108784195,
-0.026010668,
0.027649881,
-0.009604981,
-0.000010821903,
-0.01046523,
0.02166201,
0.014062017,
0.004077714,
-0.014414245,
-0.00965917,
-0.00958466,
0.0086499015,
-0.009564339,
-0.012808899,
-0.004006591,
-0.0038541849,
-0.00051310105,
-0.011176459,
-0.0074441987,
-0.03156503,
-0.01624312,
0.0057507963,
-0.03389515,
-0.0042436677,
0.0055882293,
-0.013384656,
0.0056390315,
0.016500518,
-0.028638829,
0.007843842,
0.029722607,
0.012090896,
-0.0054290495,
-0.00973368,
-0.021160763,
0.00958466,
0.018139731,
0.013059523,
-0.011738668,
-0.005923523,
-0.007911578,
0.011332252,
-0.008731185,
-0.0037220994,
-0.011643838,
-0.009083413,
0.0052529355,
0.024466284,
0.010654891,
0.007078424,
0.01354045,
0.0037085523,
-0.02395149,
-0.033813868,
-0.018085543,
-0.003396966,
-0.008473787,
-0.009076639,
0.01526772,
-0.023748282,
-0.021201404,
-0.008094465,
-0.0024283398,
-0.0044942913,
-0.025631346,
0.019778945,
0.029397473,
-0.023829564,
0.010742947,
-0.013045976,
-0.0033952727,
-0.0007395937,
0.009063092,
0.0336513,
-0.0112035535,
-0.0153625505,
0.020334382,
-0.0031802105,
-0.010262021,
-0.029262,
-0.011406762,
0.008406051,
0.038257357,
0.004233507,
-0.015877346,
-0.01956219,
-0.008859884,
-0.0038982134,
0.012117991,
-0.010356852,
-0.035087306,
-0.011386441,
0.01487485,
0.0030904603,
-0.018112637,
0.032459147,
-0.036360744,
-0.033976436,
0.011555781,
-0.0068244133,
-0.0076541808,
-0.0152541725,
-0.00084119785,
0.020158267,
-0.008676996,
-0.018207468,
-0.023206392,
-0.0087718265,
0.016852746,
0.013940092,
0.045843802,
0.028124034,
-0.019873776,
0.025726177,
0.026051309,
0.01007236,
0.009638849,
-0.0056017768,
0.021445254,
-0.014197489,
0.023436695,
0.010492324,
0.010648117,
0.029912269,
-0.004534933,
0.030020645,
-0.0018542762,
0.0059404573,
-0.022122614,
-0.002294561,
-0.038474113,
-0.03335326,
0.012639559,
-0.02263741,
-0.009516924,
-0.037688375,
0.002047324,
0.05020601,
-0.00039731464,
-0.003068446,
-0.021783935,
0.027378937,
-0.012910503,
0.025780365,
-0.0031751303,
0.007931899,
0.00018299335,
-0.022366464,
0.0040506194,
-0.012145085,
0.0072206696,
-0.002711138,
0.011305157,
0.017895881,
-0.01429232,
0.0008780294,
0.00032746178,
-0.017882334,
-0.0065670162,
-0.0014029843,
-0.028611735,
-0.043730434,
-0.02014472,
-0.021689104,
-0.04839068,
0.01080391,
0.004795717,
-0.009882699,
0.014495528,
-0.008670223,
-0.02190586,
-0.013181448,
-0.0053748605,
0.012639559,
-0.015105153,
0.02595648,
0.0275686,
-0.0052901907,
-0.02038857,
-0.0077490113,
0.003952402,
-0.0012869862,
0.020713704,
0.014021375,
-0.0066110445,
-0.0016044992,
0.007437425,
0.0015604707,
-0.02044276,
-0.021865217,
0.036794256,
-0.009388225,
-0.008568618,
-0.014224584,
-0.0075525767,
-0.011908009,
0.010722627,
-0.019345434,
0.0060217404,
0.0024147925,
-0.016663084,
-0.019914418,
0.008236712,
-0.011420309,
0.03722777,
0.0044875178,
-0.01643278,
-0.0063841287,
-0.026322253,
0.0016832424,
0.003073526,
0.00084246794,
0.013967187,
0.01614829,
-0.007180028,
0.010065586,
-0.0038033829,
0.0038609584,
0.011447404,
-0.019047394,
0.039016,
0.017895881,
-0.017015312,
0.0072884057,
-0.009063092,
0.003606948,
0.0074441987,
-0.008419599,
0.0007764252,
-0.035575006,
-0.011786084,
0.015917987,
0.0009229046,
-0.0018745969,
-0.0020524042,
-0.019304793,
-0.017706221,
-0.028313696,
-0.03600852,
0.00046949595,
-0.036279462,
-0.013486261,
-0.017624937,
-0.01877645,
0.02327413,
0.0151322475,
-0.001559624,
0.008947941,
0.029966457,
0.0043655927,
0.013980734,
-0.0076270862,
0.0054155025,
-0.018505506,
0.0076948227,
-0.0027382325,
0.0056390315,
-0.0002061718,
-0.026850596,
-0.014671642,
-0.016703725,
-0.020645967,
0.0035527593,
0.0060725426,
0.023680545,
0.008351862,
0.015105153,
0.0067905453,
0.01048555,
-0.02239356,
-0.003022724,
-0.026511915,
-0.0071868016,
0.0040167514,
-0.012802126,
-0.025861649,
-0.017083049,
-0.0088124685,
-0.00958466,
-0.010262021,
0.009239206,
-0.016514065,
-0.001528296,
-0.00047880967,
0.007884484,
-0.010831005,
0.023734733,
-0.021445254,
0.029451663,
0.022772882,
-0.025604252,
-0.018451318,
0.0070513296,
-0.023247035,
0.010532966,
-0.001389437,
-0.011339026,
-0.0011701414,
-0.01624312,
-0.034572512,
-0.0035087308,
-0.034599606,
0.033542924,
0.03961208,
-0.0047686226,
-0.019833134,
0.0053917947,
-0.027148634,
-0.010275569,
-0.021960048,
0.019237056,
0.014251678,
0.026037762,
-0.01478002,
0.008317995,
-0.009008903,
0.0064857327,
-0.010255247,
-0.009449188,
0.011494818,
-0.010742947,
0.0032919752,
0.00042440908,
-0.02117431,
-0.019684115,
0.013926545,
0.0026467887,
-0.007898031,
0.0012454978,
-0.018153278,
0.026200328,
0.004175931,
0.004409621,
0.0068752156,
0.026119046,
0.035547912,
-0.026159687,
-0.013553997,
0.016202478,
0.014509075,
0.009449188,
-0.004040459,
0.0029939362,
0.012172179,
-0.0052055204,
0.025482327,
0.005276643,
-0.0029583748,
-0.0014173782,
0.0018796772,
0.0043520452,
0.016893387,
0.026376443,
0.003518891,
-0.0064518647,
-0.017692672,
-0.02931619,
-0.03766128,
-0.014156848,
0.0012175567,
-0.014752925,
-0.0030921537,
-0.017448824,
0.0071529336,
-0.03546663,
-0.010519419,
-0.006167373,
-0.0018051674,
-0.022122614,
0.036902636,
-0.013208542,
-0.0035053438,
-0.026999615,
0.020862723,
-0.032215297,
-0.0089750355,
-0.015281267,
0.003918534,
-0.012307652,
-0.003127715,
0.0011396601,
-0.0057406356,
0.0054933988,
0.00009599477,
-0.034762174,
-0.036523312,
0.01202316,
0.18922761,
-0.005198747,
0.00014722021,
0.0024351133,
-0.011352573,
-0.0130798435,
-0.007247764,
-0.0005029407,
0.008832789,
-0.006804093,
0.006692328,
0.00625543,
-0.011481271,
0.0027128314,
0.029424569,
0.008724412,
-0.023260582,
-0.015674137,
-0.01858679,
-0.02751441,
-0.003908374,
-0.019155772,
-0.00014923113,
0.017232068,
0.0326759,
-0.0010422894,
-0.029262,
0.005435823,
0.02804275,
0.017245615,
-0.03310941,
0.013404977,
0.015321909,
0.011982518,
-0.015565759,
-0.004998925,
-0.007938673,
-0.018424222,
0.014901945,
0.005070048,
0.0024537407,
0.0051276237,
-0.0014885011,
0.0109867975,
-0.026823502,
0.01144063,
0.0010355158,
-0.017204974,
0.017624937,
0.002660336,
-0.032594617,
0.013967187,
0.048715815,
-0.0015782515,
-0.012463445,
-0.007843842,
0.0039016001,
0.018221015,
-0.011887688,
0.024371454,
0.0072613116,
0.011582876,
-0.026132593,
0.01975185,
-0.012598917,
0.032025635,
-0.005242775,
0.008263806,
0.013730111,
-0.022529032,
0.009544019,
-0.00016087327,
-0.022759335,
-0.0015960322,
-0.0025299438,
-0.012842767,
0.026119046,
0.01177931,
0.012720842,
0.011704801,
0.023829564,
0.011731895,
-0.023829564,
-0.0067024883,
-0.024222434,
-0.038311545,
0.012639559,
0.0038711189,
0.0012615852,
-0.0073290477,
-0.012287331,
-0.0042809225,
0.0018085543,
-0.006116571,
0.012883409,
0.0013801233,
0.0056220973,
0.013581091,
0.014360056,
-0.025983574,
-0.025373949,
0.069578536,
0.0021844897,
0.0010583767,
-0.01858679,
0.013289826,
-0.0012573516,
0.006268977,
0.014915492,
-0.0041048084,
-0.0010431361,
0.007870937,
-0.003417287,
-0.010736174,
-0.014739378,
0.0132153155,
0.01389945,
-0.009347584,
-0.00070572563,
-0.012429577,
-0.016012818,
-0.01849196,
0.00062825246,
0.019846682,
-0.020740798,
0.02185167,
-0.024059867,
-0.008548298,
0.012558276,
-0.009760774,
0.00091782433,
-0.014522623,
-0.0152948145,
0.012598917,
-0.000083982195,
-0.00324964,
0.013404977,
-0.007958993,
0.0002421566,
0.02190586,
-0.009963983,
0.008480562,
0.027690524,
0.00625543,
0.00027962314,
-0.019914418,
0.036171086,
-0.00006493142,
-0.022854164,
-0.011521913,
-0.030670913,
-0.024913343,
-0.01877645,
0.0007747318,
0.026362896,
-0.021594273,
-0.017977165,
-0.03132118,
0.0069429516,
0.027663428,
-0.028936869,
0.008094465,
0.01731335,
-0.010350078,
-0.010133322,
-0.019358981,
-0.1712369,
0.013716563,
0.017001765,
-0.026010668,
0.029532947,
0.030562535,
0.0038067696,
0.021472348,
0.011352573,
0.009801416,
0.033082318,
-0.00010255671,
-0.044516176,
0.017394634,
0.023396054,
0.010207833,
-0.009686264,
0.027094446,
0.024466284,
-0.0002126279,
0.025631346,
-0.009930114,
0.014468434,
-0.006031901,
-0.032459147,
0.0056864466,
-0.0061944677,
-0.032513335,
-0.035249874,
-0.018722262,
-0.01119678,
0.009882699,
0.030914763,
-0.00365775,
0.015064511,
-0.010499097,
-0.021282688,
-0.010363625,
-0.0108784195,
0.00641461,
0.03199854,
0.017773956,
0.010512645,
-0.0037085523,
-0.0005334219,
0.026674481,
-0.0056627393,
0.0036543633,
0.016961124,
0.007965767,
0.033922248,
-0.016324403,
0.022122614,
0.023328317,
0.0154302865,
0.032432053,
0.015796062,
0.00020627763,
-0.0038304774,
-0.013791073,
0.0064958935,
0.0017374313,
0.037363242,
0.0036035613,
-0.004517999,
-0.042646658,
-0.014075564,
0.020849176,
-0.025644893,
0.011325479,
-0.024222434,
-0.007965767,
-0.0011625211,
-0.029289097,
0.003102314,
0.009090186,
-0.007437425,
-0.0014885011,
0.006468799,
-0.005368087,
-0.023626357,
0.00081664353,
-0.028259506,
0.0021472347,
-0.035249874,
0.020862723,
0.017977165,
0.012991787,
0.008108013,
-0.011169685,
0.012497313,
-0.028693018,
0.0068311873,
-0.01716433,
0.020347929,
0.021580726,
-0.019765398,
-0.013445619,
-0.0132695045,
-0.01234152,
0.0040167514,
-0.018640978,
-0.013791073,
0.017787503,
0.03779675,
0.004362206,
-0.029099435,
-0.0010617636,
0.05091046,
-0.025292665,
-0.008731185,
0.025306212,
0.003921921,
0.011379668,
-0.0027771806,
0.04443489,
-0.00990302,
0.0012268703,
0.021648463,
-0.025550062,
0.051696204,
-0.00039540956,
0.010451683,
0.03237786,
0.027460221,
-0.019914418,
-0.14457597,
-0.03126699,
0.02078144,
0.026701577,
-0.03858249,
0.0023690707,
0.0038745056,
0.021824576,
-0.038799245,
0.024168245,
-0.006221562,
-0.016107649,
0.010946156,
-0.007471293,
0.0395037,
0.0066855545,
0.00707165,
-0.021878764,
-0.030698007,
0.03107733,
-0.003918534,
0.003695005,
0.013872356,
-0.027880184,
-0.011169685,
-0.005855787,
-0.03809479,
0.014441339,
0.015633496,
0.00340882,
0.013594639,
-0.0052935774,
0.026823502,
0.016012818,
-0.03432866,
-0.0054967855,
-0.019277697,
-0.028476262,
0.055245575,
-0.016053459,
0.0067024883,
0.005981099,
0.010912288,
0.0180449,
0.0061639864,
-0.011813179,
-0.022109067,
0.0037830619,
0.017489465,
-0.03189016,
-0.02239356,
-0.024669493,
-0.00022649263,
0.0018441157,
0.0131746745,
-0.020131173,
0.017719768,
0.024466284,
0.001023662,
-0.022136163,
-0.010614249,
-0.009205338,
0.0048600663,
0.005825306,
0.02093046,
-0.0077625588,
-0.014996775,
-0.018085543,
0.018722262,
-0.0075728977,
-0.002333509,
-0.021702651,
-0.020740798,
-0.013770752,
-0.03351583,
0.009300169,
-0.0025536516,
0.0004483284,
-0.0055950033,
0.0012692055,
-0.006638139,
-0.021824576,
0.0072951796,
-0.0199957,
0.031456653,
-0.0034748625,
0.0023064148,
-0.0050497274,
-0.00965917,
-0.017922975,
-0.022407107,
0.017110143,
-0.00503618,
-0.009435641,
-0.027582146,
0.021201404,
0.019155772,
-0.0022928675,
0.01956219,
0.016947575,
-0.02380247,
-0.009862378,
-0.060799938,
0.0032225456,
-0.0021184469,
0.0024689813,
-0.004098035,
-0.012842767,
0.010444908,
-0.0031090877,
-0.0013691162,
0.032811373,
-0.013581091,
0.024154698,
0.0022471456,
-0.013425298,
-0.014102659,
-0.01129161,
0.0038914396,
-0.0031327952,
-0.00853475,
0.028259506,
0.002623081,
0.013432072,
0.00853475,
-0.011670932,
-0.00090935733,
-0.0032343995,
-0.01200284,
0.014265225,
-0.010742947,
0.00308538,
0.024059867,
-0.039828837,
-0.017543653,
0.0024622078,
-0.023992132,
-0.014847756,
-0.011745443,
0.018789997,
0.008013182,
0.038474113,
0.0062317224,
-0.04551867,
0.011108723,
-0.005056501,
-0.0087718265,
0.018573243,
-0.035656292,
0.013249184,
-0.0049040946,
0.005313898,
0.009225659,
0.011840273,
-0.008297674,
-0.0043317247,
0.007891257,
-0.0070851976,
0.014969681,
-0.005943844,
-0.008453467,
-0.014766473,
0.032757185,
0.018708715,
0.024466284,
0.011162912,
-0.0036171086,
-0.001811941,
-0.04985378,
-0.014576811,
-0.002458821,
-0.011332252,
-0.0110409865,
-0.018939018,
0.003173437,
-0.003400353,
0.023179298,
-0.012964692,
-0.021309782,
0.011332252,
-0.008209617,
0.025279118,
0.0042809225,
0.007796427,
-0.018464865,
0.012483765,
0.034762174,
0.0010710773,
-0.011169685,
0.0006269824,
0.022054879,
0.014983228,
-0.017665578,
0.019508,
-0.008257032,
0.019589284,
-0.0049481234,
-0.004968444,
-0.02473723,
-0.01599927,
0.019873776,
0.03286556,
0.006695715,
0.008189296,
-0.007335821,
-0.002895719,
-0.023084467,
0.021282688,
-0.008060598,
-0.0414545,
-0.0066855545,
0.0018424223,
0.014224584,
-0.009388225,
-0.0055204933,
0.0069294046,
-0.008751506,
0.014211037,
0.008900525,
-0.010011397,
-0.0082909,
0.030833479,
-0.002900799,
0.011460951,
0.006025127,
0.0155251175,
0.0070106876,
0.007958993,
0.03985593,
-0.03107733,
0.041048083,
-0.014725831,
0.0024401934,
-0.0053816345,
-0.034030624,
-0.016744368,
-0.012937598,
0.00026861602,
0.0012175567,
0.00535454,
-0.021323329,
0.07976605,
0.01031621,
-0.020415666,
-0.0055543613,
-0.029858079,
0.0076745017,
0.02273224,
-0.0020066823,
0.0020574844,
-0.016026365,
0.010553286,
-0.024168245,
0.01404847,
-0.024547568,
-0.005107303,
0.020307288,
-0.0019728143,
-0.0134185245,
0.006760064,
-0.015647043,
0.024168245,
0.008406051,
0.0052021337,
0.033570018,
-0.04015397,
-0.005679673,
0.029099435,
0.022312276,
0.0153490035,
-0.04248409,
-0.013513355,
-0.006482346,
-0.037688375,
-0.00031751304,
0.0036204953,
-0.0030548987,
-0.0026688029,
-0.026891237,
0.03370549,
0.035764668,
-0.008243485,
0.011542234,
-0.030589629,
-0.021404613,
0.0027483928,
-0.0055882293,
0.0044401023,
-0.027961468,
-0.0020676448
] |
RATIONALE Multiple biological mechanisms contribute to the efficacy of cardiac cell therapy. Most prominent among these are direct heart muscle and blood vessel regeneration from transplanted cells, as opposed to paracrine enhancement of tissue preservation and/or recruitment of endogenous repair. OBJECTIVE Human cardiac progenitor cells, cultured as cardiospheres (CSps) or as CSp-derived cells (CDCs), have been shown to be capable of direct cardiac regeneration in vivo. Here we characterized paracrine effects in CDC transplantation and investigated their relative importance versus direct differentiation of surviving transplanted cells. METHODS AND RESULTS In vitro, many growth factors were found in media | [
-0.02412401,
0.014935186,
-0.012262926,
-0.017681118,
-0.007052355,
0.0114994235,
-0.0036735202,
0.0011477658,
-0.040237937,
-0.012778626,
-0.009751405,
0.020976234,
-0.033594124,
-0.009925537,
-0.0038041193,
0.01263798,
0.03817514,
-0.009262495,
0.011506122,
0.023320323,
-0.016194297,
0.01698459,
-0.013783235,
-0.0071662106,
-0.013689471,
0.022784531,
0.030861586,
-0.01474766,
-0.0033587427,
-0.018739305,
-0.007829253,
-0.0028815533,
-0.0065299585,
-0.005438283,
0.0033721374,
-0.011660161,
0.0033302787,
-0.0039380672,
0.01186778,
0.015296846,
0.024539249,
-0.000107681524,
-0.00041314543,
-0.004976163,
-0.009336166,
0.010159945,
-0.010253709,
-0.035951607,
-0.01762754,
0.019355467,
0.048515916,
-0.022945268,
-0.0035462696,
0.024981275,
-0.016020164,
-0.028343366,
-0.01690422,
0.021579001,
0.028289787,
-0.041523837,
0.0030824752,
-0.005361263,
-0.016502377,
0.000092874005,
0.00045709708,
0.012175861,
0.0060879304,
0.0055521387,
0.008331557,
0.0026772828,
0.021150367,
0.016033558,
0.015015556,
0.018096356,
0.006432846,
-0.031156272,
-0.027968314,
-0.0065600965,
-0.006389313,
0.016663114,
-0.010722526,
-0.026186807,
0.005927193,
0.032388594,
-0.0020075436,
-0.0068145976,
-0.015872821,
0.01762754,
0.012644678,
-0.0014064525,
0.024552643,
0.032147486,
0.0040083895,
0.01222944,
-0.009818378,
0.0027894643,
0.0054885135,
0.035442606,
-0.010977027,
-0.017774882,
-0.0027844412,
-0.0078091603,
-0.029522108,
-0.019275097,
-0.031531326,
0.0011017212,
0.0026890032,
-0.0059606796,
0.042916894,
-0.00091335695,
-0.016676508,
0.037425034,
-0.01934207,
-0.014908397,
0.02820942,
0.010615368,
0.011559701,
0.015966585,
-0.00958397,
0.0017279274,
0.036567766,
0.009202218,
0.045542274,
-0.028691633,
0.02222195,
0.0009125198,
-0.008760191,
0.021110183,
-0.0056124153,
0.0136158,
-0.0024897559,
-0.0042093117,
-0.0048187743,
0.027673628,
-0.011680254,
-0.017145326,
-0.0019690336,
0.0034022757,
-0.014506553,
-0.045113638,
0.0019238262,
0.0026973751,
0.0013788257,
-0.002124748,
-0.032977965,
-0.005816686,
0.030888377,
0.019931441,
0.010052787,
0.0066371164,
0.007909621,
-0.010287195,
0.018417832,
-0.0101264585,
0.0026906778,
0.01723909,
-0.010849777,
0.016837247,
0.0074341064,
-0.018618753,
0.009630851,
-0.01659614,
0.01785525,
-0.0027492798,
0.012745139,
0.0140779205,
0.004688175,
0.015765663,
0.007728792,
-0.01944923,
-0.007815857,
0.045194007,
-0.019261703,
0.018257093,
-0.027137836,
-0.0031846103,
-0.002538312,
0.022114791,
-0.03193317,
-0.030299006,
-0.020118969,
-0.0026655623,
0.024887513,
0.011010515,
0.016582746,
-0.015805848,
0.026749387,
-0.025369724,
-0.011907965,
-0.022771137,
-0.018176725,
0.004798682,
-0.027352152,
-0.01145924,
-0.62666166,
-0.028959528,
-0.019060781,
-0.023936482,
0.021980844,
0.018900042,
0.020360075,
-0.01238348,
-0.0152298715,
0.009034784,
0.000362915,
0.0056459024,
0.00010490838,
-0.02725839,
-0.016663114,
-0.029575687,
-0.00340395,
-0.0036902635,
0.023119401,
-0.00046839894,
-0.02309261,
-0.019851074,
-0.016113928,
0.024525853,
0.0024696637,
0.033567335,
0.031531326,
0.006871525,
-0.006918407,
0.025677806,
0.0059774234,
0.01762754,
-0.011352081,
-0.008277978,
0.04457785,
0.02818263,
-0.021123577,
0.0050967163,
-0.018096356,
0.031611696,
-0.015404004,
0.009959023,
0.030138269,
-0.0023625053,
-0.014185078,
0.024820538,
0.017975803,
-0.0058769626,
-0.031531326,
0.018739305,
-0.005739666,
-0.0013972436,
-0.007916318,
0.021003025,
0.008612848,
-0.007507778,
0.03378165,
-0.017252484,
-0.002692352,
-0.00064462406,
0.006476379,
0.015578136,
-0.02591891,
-0.040264726,
0.0174668,
0.011840991,
-0.025316145,
-0.0011385569,
0.0057798503,
-0.019918047,
0.024324931,
0.01600677,
0.0021766527,
-0.019717125,
-0.004832169,
0.016408613,
0.004038528,
-0.006258714,
-0.0031578208,
0.013876999,
-0.000233153,
-0.015470978,
-0.0015328658,
0.008331557,
0.009168731,
0.007293461,
-0.033379808,
0.044095635,
0.006342431,
0.010468026,
0.004621201,
0.0020159152,
0.0060008643,
-0.061562438,
-0.009463416,
0.03383523,
-0.009724615,
-0.013046522,
-0.0027224903,
-0.0008698239,
-0.013810025,
0.0057664555,
0.025637621,
0.02538312,
0.007239882,
-0.0039682053,
-0.048944548,
-0.013562221,
0.049721446,
-0.05888348,
-0.0017714604,
-0.012644678,
-0.009490206,
0.020869076,
-0.0020594483,
-0.023909694,
0.015457584,
0.015189688,
-0.00022226974,
-0.017105142,
0.016488982,
-0.023681981,
0.00036312427,
0.010012602,
0.02762005,
0.014211868,
-0.001365431,
-0.0036969609,
0.025584042,
-0.008157425,
0.013180469,
-0.013100101,
0.026320755,
-0.009630851,
0.028450526,
0.013783235,
0.018498199,
0.0052541047,
0.005404796,
-0.009262495,
-0.017105142,
-0.008331557,
0.0061180685,
-0.0048154257,
-0.008257885,
0.0028447176,
-0.034263864,
-0.0063692206,
-0.026762784,
-0.0049862093,
-0.007146118,
-0.011666859,
0.01222944,
0.0031276825,
0.024003457,
-0.013381392,
0.0010941866,
-0.031450957,
-0.007909621,
-0.04449748,
-0.0042126602,
0.018337462,
-0.015604925,
0.012919271,
-0.017815065,
-0.021351289,
-0.003861047,
0.0031142877,
0.0019171288,
-0.033620913,
0.006144858,
-0.021900475,
0.020239523,
0.010186735,
-0.00045500413,
0.0045843655,
-0.0048489124,
-0.0040988047,
-0.024324931,
-0.0016852316,
0.00012568077,
-0.04757828,
-0.008880743,
0.004785287,
0.011171252,
0.0085927555,
0.03319228,
0.0058133374,
-0.003509434,
0.04069336,
-0.0025450094,
0.019810889,
-0.02127092,
0.011774017,
0.014198474,
-0.013394786,
-0.008445413,
-0.0016157461,
0.0028815533,
0.010394354,
0.023012243,
-0.0120486105,
0.015430793,
-0.01844462,
0.00042319152,
-0.016462192,
-0.00022729278,
-0.0035362234,
0.02202103,
0.013394786,
0.0056559485,
0.020226127,
-0.022302318,
-0.005799942,
0.009021388,
0.010025998,
0.015913006,
-0.018766096,
0.0011929731,
0.0063524772,
-0.00094349525,
-0.015725479,
0.00009193218,
-0.01376984,
-0.010735921,
0.026910124,
-0.0027894643,
0.023748957,
-0.0028447176,
-0.0058099884,
0.004681478,
0.017118536,
0.024057036,
0.0070456574,
-0.008760191,
0.0061984374,
0.020427048,
-0.008927625,
0.021163762,
0.019234912,
0.027352152,
0.016355034,
-0.0018903392,
-0.0064361948,
-0.018257093,
-0.003552967,
0.027191415,
0.020427048,
0.0023641798,
0.019315282,
-0.015993375,
0.0060979766,
-0.012792021,
-0.015604925,
-0.0046245498,
-0.004447069,
-0.007427409,
0.012122282,
0.03120985,
0.019743914,
0.02812905,
-0.0032281436,
0.016488982,
-0.028370157,
-0.013013035,
0.0103474725,
0.028664842,
-0.0058535216,
-0.030540112,
0.00004578296,
-0.013535432,
0.015256661,
0.00657684,
-0.05183782,
0.0030975442,
0.014452974,
0.0074541983,
0.003273351,
-0.0033353018,
0.006255365,
-0.011794109,
-0.014814634,
0.013080008,
0.021471841,
-0.0021113532,
0.010702434,
-0.023802536,
0.0028899251,
-0.01780167,
0.023347111,
-0.0037170532,
0.012122282,
0.013180469,
0.00091838004,
-0.003419019,
-0.019007202,
0.0003340325,
0.009182126,
0.0344246,
-0.017279275,
-0.007902924,
0.0058736135,
-0.014278842,
-0.026012674,
0.04626559,
0.00814403,
-0.0059204954,
-0.014319026,
0.008653032,
-0.016957799,
0.0017614143,
-0.010936843,
-0.015578136,
-0.009570574,
0.009590667,
0.0027610003,
-0.007581449,
0.0075680544,
0.020051995,
0.022690767,
-0.010990422,
-0.02314619,
0.012108887,
-0.028236208,
0.04516722,
0.0049058404,
0.0039380672,
0.020266311,
-0.026133228,
0.007635028,
0.014841423,
-0.024552643,
0.018645542,
-0.009229007,
0.0140243415,
-0.019355467,
0.0060477457,
-0.019703731,
-0.0015278428,
0.029522108,
-0.020118969,
0.0037471915,
-0.002014241,
-0.008565966,
0.00031540534,
0.011941452,
0.015685294,
0.04018436,
0.020185942,
0.0009284261,
0.0066605574,
0.015966585,
0.0070389602,
-0.0050900187,
-0.024659801,
0.02381593,
0.012088794,
0.0007220627,
-0.012490638,
-0.0152834505,
-0.0027626746,
0.018230304,
0.019194728,
0.013535432,
0.016274665,
0.028959528,
0.0068916176,
0.004272937,
0.013414878,
-0.010340774,
0.006720834,
0.004534135,
-0.0070322626,
-0.036782082,
0.022704162,
-0.023052426,
-0.0152298715,
-0.0313438,
0.017292669,
-0.010005905,
-0.0074742907,
0.0035429208,
0.0067945053,
0.008391834,
-0.01145924,
-0.038469825,
0.017145326,
0.0013964064,
-0.004587714,
0.006148207,
-0.0146271065,
-0.012631283,
-0.03881809,
0.00516369,
-0.010930145,
-0.014640501,
-0.023708772,
0.01782846,
-0.00091419416,
0.013173772,
0.03195996,
-0.018645542,
-0.0083181625,
0.025008066,
0.0107292235,
-0.031611696,
-0.009195521,
-0.037317876,
-0.0042327526,
-0.008498992,
-0.010695737,
-0.011291805,
0.0003336139,
0.017064957,
0.017895434,
-0.022007633,
0.0019104313,
-0.005234013,
0.0024077129,
0.025637621,
0.027191415,
-0.0029803398,
0.0025131968,
-0.005947285,
-0.018404435,
-0.028959528,
-0.0008949391,
-0.018297277,
0.01749359,
-0.0041456865,
-0.007735489,
0.014131499,
0.0025801708,
-0.0042762854,
0.014091315,
-0.015055739,
0.013635892,
0.007072447,
0.011619977,
0.0028262998,
0.02070834,
0.014787843,
-0.0003853094,
-0.0029635965,
-0.0052708485,
-0.00062578765,
0.035442606,
-0.0140243415,
-0.026347544,
-0.010414446,
0.005893706,
-0.018645542,
-0.047149647,
0.007514475,
-0.016046954,
0.034263864,
-0.014935186,
-0.03209391,
-0.021485237,
-0.0300579,
0.0114994235,
0.014881607,
0.007139421,
-0.0029970834,
-0.018082961,
0.026039464,
0.0026237038,
0.000673088,
0.035871238,
-0.039809305,
-0.0038777906,
0.00004622771,
0.008766888,
-0.0024880816,
-0.021203946,
0.01936886,
-0.0050699264,
0.007414014,
-0.027298573,
-0.029950742,
-0.006633768,
-0.02474017,
0.033433385,
0.014372606,
0.0174668,
0.0037237506,
-0.0069451965,
0.007996688,
0.014439579,
0.001595654,
-0.0070255655,
0.007842647,
-0.013501944,
0.037076768,
-0.014828028,
-0.018658938,
0.007514475,
-0.03691603,
0.010501512,
0.026454702,
-0.0068045515,
-0.023012243,
0.00619174,
-0.013810025,
-0.013374694,
0.0028329974,
-0.014600317,
-0.0030640573,
-0.035576552,
-0.0061616017,
0.022302318,
-0.0014675662,
0.0092490995,
0.0039447644,
0.014921792,
-0.010829684,
0.0062386217,
-0.019007202,
0.00611472,
0.007768976,
-0.013709564,
-0.009758102,
-0.022489846,
0.017949013,
0.015511163,
0.00037296108,
0.027017284,
-0.023882903,
-0.021793317,
0.0074742907,
-0.031531326,
-0.03386202,
-0.015859427,
-0.033513755,
-0.012343296,
-0.01269156,
-0.018123146,
-0.026602045,
-0.0067174854,
0.0073470403,
-0.03627308,
0.020788709,
-0.01656935,
0.008572663,
0.047765806,
-0.010762711,
0.01271835,
-0.012858994,
0.013876999,
0.03303154,
-0.021485237,
0.0038242114,
-0.00798999,
-0.003941416,
0.0012725047,
0.024619617,
0.0024830585,
-0.008358346,
-0.02037347,
-0.0037137044,
0.02194066,
-0.02885237,
-0.009342863,
0.009671035,
0.020480627,
-0.00091084547,
-0.010829684,
-0.01500216,
-0.023748957,
-0.007467593,
-0.00017528333,
-0.017788276,
0.017399827,
-0.01623448,
-0.022476451,
0.03375486,
0.0103474725,
0.008545874,
-0.0039548106,
-0.026401123,
-0.022489846,
-0.014948581,
-0.020909261,
-0.0049594194,
-0.0028296486,
0.014319026,
-0.0078091603,
-0.00029280165,
0.020748524,
-0.004457115,
0.011988333,
-0.003432414,
-0.005177085,
0.045890536,
0.0054650726,
0.015872821,
0.0244053,
-0.0027660234,
0.013635892,
-0.02258361,
-0.018350856,
-0.0047518006,
-0.031879593,
-0.01782846,
0.03396918,
0.02342748,
-0.011673556,
0.002643796,
-0.027084257,
-0.017064957,
-0.006248668,
-0.01502895,
0.0044638123,
-0.033326227,
-0.005759758,
0.0051837824,
0.012899179,
0.013669379,
0.004634596,
0.018391041,
0.00783595,
0.02885237,
-0.004249496,
0.027218206,
0.012283019,
-0.009751405,
-0.02474017,
0.00052574533,
-0.025008066,
-0.026869942,
0.0002394318,
-0.012370085,
-0.03627308,
-0.023159586,
-0.0127049545,
0.01374305,
-0.010374262,
-0.0004020529,
0.020025205,
0.012899179,
-0.002640447,
0.012611191,
-0.006971986,
0.0011561374,
-0.011573095,
-0.014091315,
0.015886215,
-0.02535633,
-0.0059841205,
-0.04404206,
0.009784891,
0.013756446,
-0.018846463,
-0.016703298,
-0.01410471,
0.006201786,
-0.0344246,
-0.029843584,
-0.0050163474,
-0.012664771,
-0.013970762,
0.009369653,
0.020855682,
-0.022677373,
-0.010715829,
0.015872821,
0.01911436,
0.026802966,
-0.016529165,
0.031236641,
-0.008391834,
-0.02188708,
-0.007193,
-0.0015630041,
-0.007514475,
0.034772865,
0.0030238729,
-0.006918407,
-0.026173413,
0.008130635,
-0.05700821,
-0.018149935,
0.02034668,
0.02731197,
0.0026739342,
0.027111048,
0.00013781979,
-0.0006387639,
-0.008030174,
0.019355467,
0.0030121526,
-0.030968746,
0.032495752,
-0.007581449,
0.0128456,
-0.006761018,
-0.038630564,
-0.020560997,
0.044122424,
0.0033436734,
0.00041921495,
0.008927625,
0.012564309,
0.036058765,
-0.014345816,
0.0073001585,
0.008411925,
0.0074341064,
-0.009697825,
-0.043399107,
-0.00301885,
0.037692927,
-0.0059439363,
-0.009443324,
0.00039640194,
-0.000039687286,
0.003984949,
0.004577668,
-0.03209391,
-0.039755724,
0.014439579,
-0.007273369,
0.009724615,
-0.004155732,
-0.025517067,
0.032067116,
0.014921792,
0.0022201857,
-0.021418262,
-0.0023976667,
0.011345384,
-0.007782371,
-0.00028945296,
0.012765232,
0.0000832465,
0.006971986,
-0.0027241646,
-0.030861586,
-0.005525349,
0.0030824752,
-0.0010514907,
-0.0039246725,
0.023159586,
0.006469682,
-0.030620482,
-0.016154112,
0.015430793,
-0.021056604,
-0.01112437,
-0.00922231,
0.0069117094,
-0.00065843744,
-0.013689471,
0.014787843,
-0.0061515556,
-0.011077488,
0.004447069,
0.009001296,
-0.00164421,
0.019931441,
0.18988448,
-0.021069998,
0.00022645561,
-0.0065500503,
-0.0056793895,
-0.003124334,
-0.0034290652,
0.009229007,
-0.014948581,
0.008927625,
0.0125977965,
0.00010810011,
0.00029928976,
-0.012162466,
0.01998502,
-0.030299006,
0.004972814,
-0.004534135,
0.0030908468,
-0.019315282,
-0.020051995,
-0.01908757,
0.030379375,
0.0027241646,
0.004406885,
-0.013863604,
-0.009784891,
-0.0022972059,
0.025985885,
0.0126513755,
-0.020306496,
0.0035563158,
0.0031628439,
0.010956935,
0.02202103,
0.004038528,
-0.0020008462,
0.0018618753,
0.008827164,
-0.020413654,
0.0009158685,
-0.008552571,
-0.03372807,
0.017520381,
-0.004051923,
0.054865044,
-0.014975371,
-0.006878223,
0.02009218,
0.0023708772,
-0.051811032,
0.005361263,
0.016689904,
-0.000932612,
-0.0039447644,
-0.002951876,
0.024659801,
0.029361371,
0.009316074,
0.02535633,
-0.01950281,
0.00233739,
-0.018739305,
0.03244217,
-0.023186374,
0.014426185,
0.0024780354,
0.018739305,
0.021110183,
-0.017118536,
-0.010414446,
-0.01880628,
-0.019409046,
0.0042930287,
-0.02258361,
-0.0156719,
0.0017999244,
-0.0057664555,
-0.0006375081,
0.009731312,
0.009342863,
-0.017868645,
-0.029897163,
0.0023959924,
0.003753889,
-0.032335013,
0.016783668,
0.012765232,
-0.023320323,
-0.0072599743,
0.017306063,
-0.010916751,
-0.014319026,
-0.008197609,
0.022262134,
-0.009148639,
0.0073001585,
0.0046647345,
0.004051923,
-0.0032130743,
-0.02275774,
0.08819127,
0.017922224,
-0.013783235,
0.013013035,
0.009195521,
-0.024592828,
0.020507418,
-0.015886215,
0.0005994167,
0.00454753,
-0.016488982,
0.0046379445,
-0.006020956,
0.00164421,
0.03509434,
0.040291518,
-0.028504105,
0.045220796,
-0.021954054,
-0.0041523837,
-0.0023440875,
-0.011633372,
0.039032407,
0.007072447,
-0.010722526,
-0.0051904796,
0.009503601,
-0.0140779205,
-0.025316145,
-0.0228649,
0.001595654,
-0.020614576,
0.013756446,
0.02566441,
0.015417399,
0.015779058,
0.013301022,
-0.018886648,
0.018900042,
-0.0006504843,
-0.007943108,
-0.005193828,
0.01171374,
0.017024772,
-0.015631715,
0.0012088794,
0.028396947,
-0.009322771,
-0.028879158,
0.0026304012,
0.0007568054,
-0.011331989,
-0.010307288,
0.021565605,
-0.013468457,
-0.015685294,
-0.021753132,
0.0087334,
-0.009744707,
-0.016488982,
0.015805848,
0.009389745,
-0.021337895,
-0.002302229,
-0.007969898,
-0.16813135,
0.0063960105,
0.027178021,
-0.013609103,
0.034692496,
0.00064462406,
-0.002062797,
0.005538744,
-0.0052139205,
0.010501512,
0.040479045,
0.01782846,
-0.015216477,
-0.038362667,
0.0029820143,
0.0013252466,
-0.007159513,
0.04254184,
0.021525422,
0.006985381,
0.02034668,
-0.009182126,
0.016957799,
-0.015578136,
0.017332854,
-0.015658505,
0.0013679425,
-0.012363387,
-0.010099669,
-0.021203946,
-0.017895434,
-0.0023876205,
0.03447818,
-0.015578136,
-0.0024026898,
-0.012631283,
0.004989558,
-0.018324068,
0.009369653,
0.02625378,
0.021538816,
0.00047635208,
-0.029388161,
-0.005927193,
-0.017949013,
0.011559701,
-0.01780167,
-0.0313438,
0.007923016,
-0.005515303,
0.011532911,
-0.007943108,
0.006767716,
0.023333717,
0.009764799,
0.0145199485,
0.019998416,
0.008378439,
-0.011720438,
0.0114994235,
0.007789068,
0.01299964,
0.016274665,
0.0027626746,
0.022382688,
-0.03884488,
0.0035127827,
-0.004524089,
-0.023949878,
0.025316145,
-0.047149647,
-0.0029502017,
0.015537952,
-0.022744346,
0.030138269,
0.011673556,
-0.013863604,
0.010052787,
0.0009945629,
0.018123146,
-0.002014241,
0.024941092,
-0.015042345,
-0.012932666,
-0.0065835374,
0.016663114,
0.018149935,
0.0066605574,
0.0062988983,
-0.0038074679,
0.005451678,
-0.048542704,
-0.004423628,
-0.0053143813,
0.02104321,
0.032067116,
-0.0044872533,
-0.012309808,
0.011492726,
0.0050464855,
0.044926114,
-0.012222743,
-0.015913006,
0.0023876205,
0.021806711,
0.0089745065,
-0.021498632,
0.0014977045,
0.037746508,
-0.0049158866,
-0.011619977,
0.0014332421,
0.006821295,
0.049882185,
0.002561753,
0.024324931,
-0.01810975,
-0.0151227135,
-0.010514908,
-0.035415813,
0.066652454,
0.011191344,
-0.016837247,
0.033995967,
0.009336166,
-0.024807144,
-0.12966153,
-0.012885784,
-0.00049686286,
0.0336477,
-0.019810889,
0.010822987,
-0.010702434,
0.009985813,
-0.010059484,
0.026762784,
-0.018350856,
-0.019918047,
0.0029686196,
-0.010260406,
0.037157137,
0.0057798503,
-0.0009736335,
-0.0029736424,
-0.015872821,
0.019891256,
0.011305199,
-0.008398531,
-0.022422872,
-0.014586922,
0.011070791,
0.03195996,
-0.03000432,
0.032147486,
0.026374334,
0.020132363,
0.015296846,
0.013810025,
0.019060781,
-0.0065132147,
-0.023106007,
-0.009858563,
0.0016534189,
-0.027807577,
0.029843584,
-0.024110615,
0.00922231,
0.01536382,
0.02070834,
-0.015470978,
0.005736317,
-0.0009493555,
-0.03260291,
-0.015136109,
0.006965289,
-0.027673628,
-0.037692927,
-0.020775313,
-0.022476451,
0.019261703,
0.014198474,
-0.018350856,
0.011030606,
0.007139421,
-0.012370085,
-0.05274867,
-0.0274861,
-0.001144417,
-0.010561788,
0.0031578208,
0.023949878,
-0.01939565,
-0.03447818,
-0.03329944,
0.031022325,
-0.031665273,
0.008083753,
-0.0015127737,
-0.017440012,
-0.011907965,
-0.024445485,
0.0006504843,
0.00006441009,
-0.02322656,
-0.0049862093,
-0.020895867,
-0.026119834,
-0.019409046,
0.029950742,
-0.010233616,
0.0014391023,
0.004895794,
0.01698459,
-0.0135287335,
0.0049292813,
-0.0161809,
-0.0038007705,
0.021900475,
-0.020239523,
-0.015404004,
-0.0020761918,
-0.008632939,
-0.012128979,
0.00737383,
0.011117673,
0.0105082095,
-0.021069998,
-0.0016542561,
-0.048194442,
0.013428273,
0.0014123127,
0.0026387728,
0.0063692206,
-0.023132795,
0.004282983,
-0.003375486,
0.017265879,
-0.011271712,
-0.023722166,
-0.009979116,
-0.012162466,
0.009751405,
-0.019435834,
-0.03560334,
0.03881809,
-0.012617889,
0.00035119455,
0.01238348,
0.0044872533,
-0.0019204775,
0.01004609,
0.025570646,
-0.0036433819,
0.0089209275,
-0.0027676977,
0.016140718,
-0.0039816,
-0.019100964,
0.0004755149,
-0.030432954,
-0.0073939217,
-0.0062051346,
-0.001125162,
0.0059305415,
0.00033424178,
0.032415383,
0.010340774,
0.035121128,
-0.011338687,
-0.015899612,
0.015604925,
0.022704162,
0.0063256877,
0.009637549,
-0.03619271,
0.02057439,
0.0056090667,
-0.0066237217,
0.022717558,
0.0034357626,
-0.01533703,
-0.043586634,
-0.016381823,
0.012336598,
0.020869076,
0.0031109392,
-0.012892482,
-0.015444188,
0.007226487,
0.0042762854,
0.007815857,
0.0009828424,
0.0075747515,
-0.0069987755,
0.0010456305,
0.01656935,
0.00020573555,
-0.01171374,
-0.01693101,
0.019824283,
0.005937239,
-0.004282983,
-0.0029702939,
0.007293461,
-0.016797062,
0.005739666,
0.000829221,
0.014305632,
0.01238348,
-0.0028062076,
-0.02219516,
0.0060510947,
0.006931802,
0.0152298715,
-0.004072015,
0.037826877,
-0.0140779205,
-0.011177949,
0.003013827,
0.011392266,
0.02325335,
0.0056693433,
0.0076283305,
0.046533488,
-0.008572663,
0.005327776,
0.011693648,
0.02325335,
0.0037572375,
0.011579793,
-0.0028748559,
-0.008385136,
-0.0052038743,
0.0067643668,
-0.026106438,
-0.021069998,
-0.03386202,
0.01934207,
0.008934323,
0.021793317,
0.0014022667,
0.0019723822,
-0.011358779,
0.009101757,
0.017346248,
-0.011693648,
-0.0069451965,
0.026990494,
0.011928057,
0.016328244,
-0.0035362234,
0.021096788,
0.0076618176,
0.0228649,
0.036728505,
0.0038911854,
0.02818263,
0.013836814,
0.03506755,
-0.001610723,
0.001572213,
-0.009188823,
0.0020108924,
-0.032040328,
0.019516204,
0.01348855,
-0.013696169,
0.07104594,
0.012879087,
-0.021311104,
0.00439349,
-0.006231924,
0.01942244,
0.0010180038,
0.030191848,
-0.03758577,
-0.04642633,
0.022851504,
-0.028343366,
0.021364683,
-0.03447818,
-0.011412358,
0.019301888,
-0.0031929822,
0.02160579,
0.01847141,
-0.01690422,
-0.0013227351,
-0.023869509,
0.0015035648,
-0.0010422817,
-0.03383523,
-0.009938931,
0.01364259,
-0.027807577,
0.010086274,
-0.022717558,
0.007943108,
0.017975803,
-0.039782513,
0.0010992097,
-0.0070791445,
0.008619545,
-0.009208916,
-0.012524125,
0.01238348,
0.018310672,
-0.018123146,
0.02471338,
-0.03321907,
-0.04739075,
-0.0063089444,
-0.01934207,
-0.021324499,
-0.023748957,
-0.01060867
] |
Plasmodium falciparum surface protein 25 (Pfs25) is a candidate for transmission-blocking vaccines (TBVs). Anti-Pfs25 antibodies block the development of oocysts in membrane-feeding assays and we have shown the activity correlates with antibody titer. In this study, we purified Pfs25-specific IgGs to convert antibody titer to microg/mL and determined the amount of antibody required to inhibit 50% of oocyst development (IC(50)). The IC(50) were, 15.9, 4.2, 41.2, and 85.6 | [
-0.029126717,
0.0003231203,
0.0038732337,
-0.017028756,
-0.009807701,
0.002177431,
-0.028749498,
-0.023333708,
-0.027254093,
-0.00007672792,
0.030931981,
-0.011579284,
0.009800965,
-0.0041965647,
-0.009720133,
0.026068546,
0.030473929,
-0.0044323266,
-0.024883,
-0.027644785,
0.0018776763,
0.012966913,
-0.014415165,
-0.019076519,
-0.01570849,
0.004045003,
0.012326987,
-0.044323266,
-0.042733558,
-0.006668698,
0.014522943,
-0.037209988,
-0.017661946,
0.011572549,
-0.02182483,
-0.055720676,
0.014671136,
-0.0025024458,
0.013755032,
0.024020785,
0.009699924,
0.041278567,
-0.0027584159,
0.010400474,
0.0047724973,
-0.0015652917,
0.0015939198,
0.010548668,
-0.04340716,
0.030231431,
-0.0040382673,
-0.009996311,
-0.006321791,
0.008824237,
-0.0059614116,
-0.004139308,
0.015748905,
0.010703597,
0.0124280285,
-0.024061201,
-0.013768503,
-0.0040618433,
-0.033976678,
-0.014495998,
-0.0014911949,
0.021595804,
-0.00080285396,
0.017864028,
0.0033798174,
0.0030396464,
0.007598274,
0.035808887,
-0.0029217654,
-0.027402285,
0.054831516,
-0.016530288,
-0.0271059,
0.021461083,
-0.0020612339,
-0.0008849497,
0.030312264,
-0.00075107056,
-0.01591057,
0.027523536,
0.0008424283,
0.013014065,
0.008642363,
0.038341645,
0.004028163,
0.002421613,
0.013485589,
0.029530881,
-0.0049307947,
0.0054359995,
-0.006308319,
0.016813202,
0.0028274606,
0.039877467,
-0.011761159,
-0.015061827,
-0.0036374717,
0.004364966,
-0.0064093596,
-0.019116934,
-0.022754407,
-0.007995701,
-0.0055673523,
-0.0012714311,
-0.005270966,
-0.025462301,
-0.0142535,
0.034650285,
-0.01596446,
-0.040335517,
-0.009134095,
0.00798223,
-0.016840147,
-0.009598884,
-0.0075107054,
0.009679716,
0.01941332,
0.011794839,
0.019022629,
-0.0022717358,
0.02182483,
-0.009235136,
-0.004577152,
-0.025785632,
-0.0037519846,
0.0008900017,
0.004866802,
0.03747943,
0.0042167725,
-0.021407194,
-0.014320861,
0.0019029366,
-0.033087518,
-0.02780645,
-0.02074706,
-0.008743404,
0.011922823,
0.019830957,
-0.004981315,
-0.010056935,
-0.005180029,
-0.0049173227,
0.013660727,
0.014725024,
0.021770941,
0.012529069,
-0.02093567,
-0.018631939,
0.005661657,
0.0045569437,
-0.022094272,
0.005200237,
0.0066990103,
0.036105275,
-0.022282882,
-0.011545604,
-0.018578049,
0.0062746387,
0.0065002968,
-0.00012588009,
0.020787477,
0.021932608,
0.00041237308,
0.024775224,
0.01011756,
-0.008857917,
-0.003933858,
0.015519879,
-0.029288383,
0.021676637,
0.011619701,
0.006557553,
0.0015383473,
-0.009208192,
-0.0059917243,
-0.028991995,
-0.022026911,
0.019830957,
0.03284502,
0.010400474,
-0.019022629,
0.015223493,
0.021151224,
-0.023845647,
-0.0008664255,
-0.016018348,
0.008433545,
0.0019079886,
0.022215521,
-0.007477025,
-0.6462305,
-0.010447627,
0.009477634,
-0.01794486,
0.008662571,
0.008433545,
0.027213676,
-0.011666854,
-0.029692546,
0.02278135,
0.0018103158,
0.028022004,
-0.019898318,
-0.01263011,
0.009275553,
-0.034704175,
-0.014266972,
-0.00044963192,
0.0144421095,
0.0015838158,
-0.018618466,
0.0128524,
-0.000399322,
0.02901894,
0.008500906,
-0.008036118,
0.029746436,
-0.025879936,
-0.007153694,
0.010070408,
-0.009747077,
0.05229876,
-0.0014019422,
0.012582958,
0.04079357,
-0.024222868,
-0.00029512358,
0.00798223,
0.019952206,
0.046047695,
-0.033518627,
0.000921998,
0.01635515,
-0.012111434,
-0.007685843,
0.03141698,
0.013431701,
0.0020275537,
-0.0068472037,
-0.02036984,
0.01269747,
-0.011067344,
-0.02233677,
-0.004014691,
-0.01686709,
0.009221665,
0.025906881,
-0.03359946,
0.01820083,
0.00051699247,
-0.012946704,
-0.00087568763,
0.0020477618,
-0.020693172,
-0.024829112,
-0.016786259,
-0.0025546502,
0.0055168318,
0.009632564,
-0.019494154,
0.012785039,
0.02170358,
-0.0027196836,
0.016961396,
0.0058367946,
0.022619685,
-0.009868326,
-0.020221649,
-0.022282882,
0.00016566494,
0.010360058,
0.0118554635,
-0.022767877,
0.020976087,
0.0064497762,
0.0075443857,
-0.027078956,
0.014078363,
0.02799506,
-0.011895879,
0.012023864,
0.007335568,
0.008076535,
-0.023724398,
-0.018928325,
0.002755048,
-0.011511924,
-0.008224728,
0.012266363,
-0.009464162,
-0.01883402,
-0.010050199,
-0.005284438,
-0.022444548,
0.035216115,
-0.0086491,
-0.0399583,
0.014873218,
0.028237557,
-0.025206331,
-0.018726243,
-0.013613574,
-0.008494169,
-0.04523937,
0.023495372,
-0.023643566,
0.010461099,
0.0008601105,
-0.0004812072,
-0.017271254,
0.010925887,
0.017190421,
0.011370467,
0.0078273,
-0.01693445,
0.014967523,
0.0073086238,
-0.020006094,
0.0044289585,
-0.020585395,
-0.0040685795,
0.005294542,
0.021339834,
-0.0008563214,
0.029692546,
0.009922214,
0.03112059,
0.01838944,
-0.0014272024,
-0.03650944,
-0.017971804,
-0.02055845,
-0.002864509,
-0.007032445,
-0.0013185835,
-0.03373418,
-0.00077464676,
0.012279835,
0.016543759,
-0.008534586,
0.025381468,
-0.010137768,
0.011168385,
0.011101024,
0.013101634,
-0.017432919,
-0.010171449,
-0.033249184,
-0.006176966,
-0.0031592115,
0.015519879,
-0.011747686,
0.0026169587,
-0.001597288,
-0.018214302,
-0.017527224,
0.028048947,
0.0184568,
-0.0051126685,
-0.020315953,
0.0070795976,
-0.03640166,
-0.006998765,
0.020962615,
0.0050015235,
0.027052011,
0.008507642,
0.0038496575,
-0.013229619,
-0.016260846,
-0.011949768,
-0.015519879,
-0.015277381,
0.013121842,
0.050735995,
0.00021197535,
0.014522943,
0.0057088095,
0.014940578,
0.029045885,
-0.00040795255,
0.002066286,
-0.028965052,
0.0106295,
0.0008832657,
-0.012832192,
0.02761784,
0.015371686,
0.008575003,
0.012374139,
-0.005523568,
-0.0109595675,
0.011949768,
-0.017864028,
0.024344116,
-0.029450048,
-0.0028695608,
-0.02418245,
0.027375342,
0.023198986,
0.004967843,
-0.0020022935,
-0.023212457,
-0.019211238,
0.0076925787,
-0.0046377764,
0.013957113,
0.0056919693,
0.0011021876,
-0.0119295595,
-0.012246154,
0.009760549,
0.028911164,
0.0060018282,
-0.010440891,
0.010366794,
0.027025066,
0.022740934,
0.015748905,
0.015950987,
-0.025287164,
-0.015061827,
0.0115321325,
0.0018473641,
-0.004577152,
-0.0132969795,
0.006321791,
-0.01269747,
0.044996873,
-0.0052305497,
0.011936296,
-0.0106295,
0.02513897,
-0.0077734115,
0.007012237,
0.0019383009,
0.0067562666,
0.020908726,
0.015452518,
0.020881781,
-0.0111077605,
0.003789033,
-0.023010377,
0.004829754,
-0.013202675,
0.018119998,
-0.012556014,
0.023239402,
0.006291479,
0.012199002,
0.009969367,
0.0055707204,
0.0012512229,
-0.012683999,
-0.002057866,
0.012326987,
-0.007477025,
-0.025085082,
-0.011235746,
-0.00045426295,
-0.021986496,
0.006325159,
0.008372921,
-0.0013985742,
-0.028022004,
0.0063824155,
0.0063689435,
0.0065642893,
0.0070526535,
-0.0019854533,
-0.038072202,
-0.015263909,
-0.0069111963,
0.014186139,
0.00029133452,
-0.028210614,
-0.022727462,
-0.010366794,
-0.019763596,
0.015641129,
-0.0013960481,
0.0029958622,
-0.0018776763,
0.0014179404,
-0.012151849,
-0.031470865,
0.02081442,
-0.015870154,
-0.002056182,
-0.016018348,
-0.013862808,
-0.004742185,
-0.02621674,
-0.02226941,
0.011700533,
0.0049577393,
-0.015169604,
-0.004253821,
-0.013350869,
0.0025024458,
0.009598884,
-0.0017446391,
-0.010770958,
0.019399848,
-0.0070526535,
0.020477619,
-0.013532742,
0.0039540664,
0.038530257,
0.0021925871,
-0.026176324,
0.003566743,
0.0068842517,
-0.03454251,
0.024168978,
0.03136309,
-0.0019972413,
0.0068404675,
0.011350259,
0.02310468,
-0.004961107,
-0.028911164,
0.017661946,
0.007901397,
-0.034003623,
-0.0014878269,
0.009848118,
-0.012360668,
-0.014159195,
0.013391284,
-0.002421613,
-0.025879936,
0.01001652,
0.020396786,
0.0055909287,
0.00095736235,
0.008278616,
0.044700485,
0.01266379,
-0.0124010835,
0.005958044,
0.026499655,
0.004816282,
-0.0048937467,
-0.0039810105,
0.0018136838,
0.005405687,
0.017257782,
-0.00041847763,
-0.022377187,
-0.017096117,
0.012596429,
0.0011762843,
0.022040384,
0.015681544,
0.026769096,
0.0023896168,
0.012380876,
-0.0051530846,
0.0029133453,
-0.010939359,
-0.012097961,
0.007369248,
-0.027752561,
0.027186733,
0.01469808,
-0.024411477,
-0.01826819,
-0.00064203056,
-0.013903225,
-0.008810764,
0.0014718288,
0.007578066,
-0.035862777,
-0.018241247,
-0.030312264,
0.0035061184,
0.0014583567,
-0.00115355,
-0.0011341838,
0.022511907,
-0.03257558,
-0.018860964,
-0.016813202,
-0.003088483,
-0.030366153,
-0.029315326,
0.000112934234,
-0.0003801663,
0.02602813,
-0.0038563935,
-0.01679973,
0.0068370993,
-0.005718914,
-0.007032445,
0.001039037,
0.0009438902,
-0.028668666,
0.000804959,
0.026647847,
0.026890347,
-0.019615402,
-0.0069448766,
0.013674199,
-0.009902006,
0.0048600663,
-0.01781014,
0.004058475,
-0.004593992,
-0.0042605572,
-0.0007784358,
0.031901974,
-0.012643582,
-0.012151849,
0.027833395,
-0.028560888,
0.01934596,
-0.024600087,
-0.0014650928,
0.023683982,
-0.00391365,
-0.00808327,
-0.03621305,
-0.022175105,
-0.001031459,
-0.0025411781,
-0.0060186684,
0.016193485,
0.022713989,
0.01640904,
0.010205129,
0.013761768,
0.017392503,
-0.00070602313,
-0.012683999,
0.016180012,
0.03144392,
-0.006658594,
-0.017877499,
0.0049038506,
0.01724431,
-0.019817485,
-0.011175121,
-0.0172982,
0.00322152,
0.0299081,
0.0060051964,
-0.014536414,
-0.038988307,
-0.004007955,
-0.0036576798,
-0.0012167005,
0.00013282665,
0.0023896168,
-0.016382094,
-0.0172982,
0.005439367,
-0.007241263,
0.032925855,
-0.025273692,
-0.017042229,
0.018214302,
0.00070770714,
0.01514266,
0.0030750108,
-0.008399865,
-0.035593335,
0.0068539395,
-0.026203267,
-0.027186733,
-0.013337396,
-0.010696861,
0.033491682,
0.0077936198,
0.020598868,
-0.009881798,
0.008386393,
0.019615402,
0.0013674198,
0.0009548363,
0.01782361,
0.009053263,
-0.03734471,
0.015425574,
0.024101617,
-0.020181231,
0.010481307,
-0.012111434,
0.02049109,
0.01724431,
-0.04014691,
-0.014240027,
-0.0036341036,
-0.0082718795,
-0.0064800885,
0.00030733267,
-0.0043346537,
0.028156726,
-0.037964426,
-0.014280444,
0.021555388,
0.010333114,
0.019022629,
-0.0055202,
0.018860964,
-0.008958958,
-0.007140222,
-0.020625811,
0.019494154,
0.015492935,
-0.0020393417,
0.0134721175,
-0.018119998,
0.043622717,
-0.0049038506,
-0.007355776,
0.00437507,
0.012636846,
-0.017904444,
0.0058502667,
-0.021743998,
-0.00478597,
-0.021110808,
-0.018941797,
-0.023508845,
-0.0024300332,
-0.024936888,
-0.037694983,
-0.00006483457,
0.009282289,
-0.026755625,
-0.0020225015,
-0.0073086238,
-0.020518035,
0.028803386,
-0.007490497,
0.02596077,
-0.012118169,
0.038530257,
0.038206924,
-0.007928341,
-0.027698673,
-0.015290853,
-0.011134705,
0.0031726835,
0.026041603,
0.03233308,
0.00020723905,
-0.024977306,
0.0011661801,
0.022916071,
-0.011619701,
-0.025974242,
0.025974242,
0.0042336127,
-0.0087703485,
-0.013162258,
0.00410226,
-0.037183043,
0.027914226,
-0.017015284,
-0.013741559,
0.00878382,
-0.012758095,
-0.03510834,
0.0102388095,
0.01469808,
0.02151497,
-0.013088162,
-0.018753188,
-0.0025007618,
-0.03874581,
0.0032905645,
0.0016132861,
-0.0018625202,
0.03912303,
0.012946704,
0.014145723,
0.0035094866,
-0.0037082003,
-0.01015124,
0.0069583487,
-0.0011737582,
0.035593335,
0.0034236019,
0.011592757,
0.0019484049,
0.013714615,
0.011639909,
-0.018187359,
-0.0062409583,
-0.0075376495,
-0.0082718795,
-0.018187359,
0.042922165,
0.0042908695,
-0.020868309,
-0.0040551075,
-0.018820548,
-0.0017168529,
-0.026701737,
-0.030177543,
0.016247373,
-0.049550448,
0.0016865407,
-0.002766836,
-0.0010996616,
0.00507562,
0.012670526,
-0.0067360587,
0.0066451216,
0.025947297,
-0.03284502,
0.00015892889,
0.021326361,
0.0051261405,
-0.03322224,
-0.011734214,
-0.035296947,
-0.029503936,
0.0018658882,
-0.019063046,
-0.023347178,
-0.014630719,
-0.024505781,
0.030339208,
0.010279225,
-0.036186107,
0.032279193,
0.011969976,
0.013755032,
-0.015600712,
0.011633174,
0.024856057,
-0.00013977321,
0.013903225,
0.031659476,
-0.010009783,
-0.023454957,
-0.011666854,
-0.008635627,
0.0022262675,
-0.027038539,
-0.0037250405,
0.0116803255,
0.0064767203,
-0.019494154,
-0.013579894,
0.012596429,
-0.015924042,
-0.0032888807,
-0.002640535,
-0.0005835111,
-0.025058137,
-0.019399848,
-0.01782361,
-0.0022346873,
-0.0002656533,
-0.020127343,
0.0060456125,
0.0056919693,
-0.025462301,
-0.018604994,
0.0045401035,
-0.007463553,
0.027078956,
0.010602556,
-0.012906289,
-0.0090195825,
-0.0028560888,
-0.03136309,
0.008514378,
-0.016813202,
-0.004466007,
0.013303716,
0.006806787,
0.0016031819,
0.025475774,
0.00066265976,
0.015950987,
-0.008258408,
-0.012158586,
0.009134095,
-0.019628875,
0.010171449,
-0.005169925,
-0.045266315,
0.0046478803,
0.05599012,
-0.0045367354,
-0.0037822968,
0.0411169,
-0.015048355,
0.0084470175,
-0.018631939,
0.0010895574,
-0.00016250741,
-0.014927106,
0.0063958876,
-0.005735754,
-0.013020801,
0.01155234,
0.021770941,
0.013121842,
-0.009107151,
0.02920755,
0.0019147247,
-0.00088747573,
-0.026580486,
-0.01597793,
0.01692098,
-0.020612339,
0.033545572,
0.00017124324,
0.0023946688,
-0.008554795,
0.02011387,
0.005439367,
0.0016772785,
0.01914388,
-0.0075107054,
-0.010838319,
0.017163478,
0.0066990103,
0.007854245,
0.0065743933,
0.002182483,
-0.0026725312,
-0.0014701448,
-0.007881189,
-0.025677856,
-0.025879936,
0.03303363,
0.015735433,
0.0031423713,
-0.0028139884,
0.003228256,
-0.0042908695,
-0.017661946,
0.00528107,
-0.0018119997,
-0.0026102227,
-0.0094911065,
0.010481307,
-0.022417603,
-0.0077532036,
-0.0131487865,
0.01450947,
0.0018322079,
0.016705425,
0.18472967,
0.01336434,
0.019628875,
0.019453738,
-0.011478243,
0.01774278,
0.002879665,
-0.0068269954,
-0.00006778159,
0.020962615,
0.021851774,
0.000071412745,
0.0019366168,
0.0077868835,
-0.013478853,
-0.020208176,
-0.030554762,
-0.010440891,
-0.010218601,
-0.01648987,
0.009214928,
-0.004132572,
0.0162339,
-0.00087063556,
0.01896874,
0.02003304,
-0.0057930104,
-0.0056582894,
0.012367403,
0.0014069942,
-0.00015808687,
0.012744623,
-0.0008289562,
-0.0011922824,
-0.0026169587,
0.0053551667,
-0.0033663453,
-0.020949142,
0.0125021245,
0.024384532,
-0.014078363,
0.02799506,
0.00138426,
-0.002867877,
-0.03640166,
0.00037174622,
-0.0072210548,
-0.02093567,
-0.0062712706,
-0.00069423503,
-0.02411509,
0.010164713,
0.0040854197,
-0.0031709997,
-0.01333066,
-0.00095988833,
0.024761751,
0.015277381,
-0.020949142,
0.028156726,
0.0027314718,
0.008292088,
-0.023953425,
0.040389407,
-0.008696252,
0.04849962,
-0.015856681,
-0.003095219,
-0.0103870025,
-0.01648987,
-0.019507626,
-0.009046527,
-0.006348735,
0.006678802,
-0.008581739,
-0.023185514,
0.028291445,
0.026082018,
0.019386377,
0.014684607,
-0.005718914,
-0.010898943,
-0.019009158,
0.00047657616,
-0.024168978,
-0.037533317,
0.03365335,
0.0048769065,
-0.026001187,
0.012333724,
0.0068404675,
-0.0058401627,
-0.015317798,
0.00070644415,
0.0003671152,
-0.010703597,
0.0064632483,
0.0026186428,
0.0015585555,
-0.010737278,
-0.008945486,
0.07776106,
-0.0028274606,
-0.005857003,
-0.012387612,
0.0076656346,
-0.007470289,
-0.004951003,
0.0096662445,
-0.02233677,
-0.005846899,
-0.033437796,
-0.0024788696,
-0.012172058,
0.007099806,
0.021838302,
0.018470272,
0.014522943,
0.020827893,
0.007908133,
0.00024397162,
-0.03874581,
0.019211238,
0.024653975,
-0.0077599394,
-0.0018675722,
-0.021784414,
0.015816266,
0.0081977835,
-0.020289008,
0.0074029285,
0.0033444532,
-0.005190133,
-0.006308319,
-0.002187535,
0.010218601,
-0.00786098,
0.0022346873,
-0.0098144375,
0.009787493,
0.00018734662,
-0.016072236,
0.005429263,
0.0107103335,
-0.010575612,
-0.022687046,
0.011141441,
0.0118554635,
-0.021393722,
-0.0002667058,
-0.023158569,
-0.027186733,
-0.017648473,
-0.011606229,
0.0026540072,
0.0011914404,
0.00416962,
-0.028156726,
0.013559686,
-0.0013076374,
-0.032413915,
-0.005284438,
0.018322079,
-0.0145903025,
0.019817485,
0.0017850555,
-0.17114978,
0.009888534,
-0.0043043415,
-0.013930169,
0.030743372,
0.009518051,
0.009437218,
0.0067057465,
-0.023778288,
-0.020854838,
0.031093646,
0.010723805,
-0.0060018282,
-0.019467209,
-0.015856681,
0.00078096177,
-0.027968116,
0.010885471,
0.025852993,
0.024303699,
0.047206298,
-0.023603149,
-0.022673573,
0.0017033808,
0.0065104007,
0.029369215,
-0.0022346873,
0.0011367099,
-0.003987747,
-0.004462639,
-0.04467354,
0.005941204,
0.036132216,
0.0050116275,
-0.0029234495,
-0.026122436,
-0.0011628121,
-0.012178794,
-0.014536414,
0.033491682,
0.028614776,
0.003334349,
0.0060018282,
-0.007739731,
-0.013889753,
0.027914226,
-0.007739731,
-0.025246747,
0.030150598,
0.0018119997,
0.02654007,
-0.018658882,
0.021986496,
0.027348397,
-0.00051320344,
-0.010871999,
0.021366779,
0.009214928,
0.022107745,
-0.00299923,
-0.0054528397,
-0.0042235088,
0.020800948,
-0.019965678,
0.015452518,
-0.018604994,
-0.0045434716,
0.016395567,
0.0036071595,
0.008487434,
-0.008042854,
-0.0149136335,
0.024653975,
-0.0064228317,
0.009376594,
0.014684607,
-0.016193485,
0.01056214,
0.0027786242,
0.021676637,
-0.013229619,
0.020464147,
-0.026418822,
0.012791775,
0.0035162226,
-0.022417603,
0.006469984,
0.0051968694,
-0.023441484,
-0.005412423,
-0.0021184904,
-0.007018973,
0.011410884,
-0.008123687,
0.036266938,
0.011720742,
-0.0016191801,
0.005607769,
-0.0060153003,
0.007227791,
0.012353932,
-0.010474571,
-0.017621528,
0.012643582,
0.03098587,
-0.01247518,
0.017271254,
-0.011269426,
0.042356335,
-0.002184167,
-0.0062746387,
-0.0028089364,
0.0072951512,
0.0124280285,
-0.011956504,
0.033761125,
0.025597023,
-0.004977947,
-0.016651537,
-0.04149412,
0.07415053,
-0.00002815462,
0.015600712,
0.03513528,
-0.01756764,
-0.011969976,
-0.12997898,
0.0033225608,
0.026742153,
0.007658899,
-0.0038934418,
0.012421292,
0.0013539478,
0.032090582,
-0.00071696925,
0.011154913,
0.00903979,
-0.026688265,
-0.007140222,
-0.009255344,
0.01888791,
0.028965052,
0.021609277,
0.008042854,
-0.006796683,
0.03562028,
-0.0102118645,
0.0065777614,
0.016126124,
0.012165322,
-0.006789947,
-0.0020140815,
-0.002664111,
0.02112428,
-0.0036475756,
0.038772754,
0.014792385,
-0.010575612,
0.013438437,
-0.0096662445,
-0.02469439,
0.0015863418,
-0.016638065,
-0.007012237,
0.030366153,
-0.005429263,
-0.007739731,
0.00038121882,
-0.0077195233,
0.0052339174,
0.0032653045,
-0.0018726243,
-0.021110808,
0.0040618433,
0.023091208,
-0.03289891,
-0.011761159,
-0.034919728,
-0.03556639,
-0.022431076,
0.006335263,
-0.03359946,
-0.023495372,
0.037694983,
-0.0030194384,
-0.00024881316,
0.004492951,
-0.005729018,
-0.0061634937,
-0.01635515,
0.021757469,
-0.005260862,
-0.0082718795,
-0.017985277,
0.016112652,
-0.016462928,
-0.016988339,
-0.012131642,
-0.013485589,
-0.0011426039,
-0.022282882,
0.0010693494,
-0.008433545,
-0.01155234,
-0.0021184904,
-0.026230212,
-0.015196548,
0.0014979311,
-0.0059310994,
0.0038833378,
0.04340716,
0.010925887,
0.020625811,
0.0027786242,
0.005665025,
0.011889144,
-0.01616654,
0.017527224,
0.0008138001,
-0.02684993,
-0.008662571,
0.038206924,
-0.014226556,
-0.020248592,
0.019777069,
0.03297974,
-0.048176292,
-0.017446391,
-0.061702296,
0.02081442,
0.031012814,
0.0040618433,
-0.0132969795,
-0.0026119067,
0.0002774414,
0.005540408,
0.0011367099,
0.0008857917,
-0.009154304,
0.0054562073,
-0.03384196,
0.012677263,
-0.019777069,
-0.0019147247,
0.035404723,
0.015479462,
0.023077738,
0.03548556,
-0.02717326,
0.005984988,
0.002169011,
0.028507,
-0.0038799697,
-0.0023323603,
0.006672066,
0.029099774,
-0.017446391,
0.021865247,
-0.005830059,
-0.028102836,
-0.02093567,
0.011202065,
-0.007988965,
0.0053787427,
0.00531475,
0.014401693,
0.024398005,
-0.005499992,
-0.00842681,
-0.010259017,
0.026432294,
-0.021946078,
0.012744623,
0.0122528905,
-0.027159788,
0.010360058,
0.014240027,
-0.0198579,
0.018955268,
0.0162339,
-0.007840772,
-0.030204486,
-0.012966913,
-0.0033730813,
-0.016786259,
-0.00967298,
-0.00070518116,
-0.023212457,
0.027415758,
0.01591057,
-0.0048769065,
0.00900611,
0.0066114417,
0.005483152,
-0.012980385,
0.015695017,
0.009632564,
-0.019628875,
-0.03149781,
-0.01673237,
0.006783211,
0.0050250995,
-0.006803419,
0.004112364,
-0.013984058,
0.012138378,
-0.0014440425,
0.030716427,
-0.004738817,
-0.002867877,
-0.03416529,
0.017890971,
0.015897099,
-0.0032973008,
0.008056326,
0.02144761,
-0.019278599,
0.009800965,
-0.011121233,
0.0066754343,
0.0007447555,
-0.00410226,
0.0070795976,
0.020154288,
0.013930169,
0.015641129,
0.011747686,
0.03869192,
-0.0162339,
-0.012050808,
0.010366794,
-0.0118554635,
0.002638851,
0.0034084457,
-0.014549887,
-0.043622717,
0.00067402684,
0.0056582894,
-0.0014482526,
0.003677888,
-0.0031760517,
0.0026051707,
-0.011868935,
0.008406601,
-0.0065205046,
0.0057155457,
-0.028668666,
0.015412102,
0.0034337058,
0.024896473,
-0.0162339,
-0.015277381,
-0.0014642507,
-0.0076791067,
0.031282257,
-0.023239402,
0.027402285,
-0.02799506,
-0.00002631273,
-0.012805248,
-0.010622764,
-0.0076252185,
0.01584321,
-0.0046579847,
0.0133980205,
-0.00019145141,
0.0033023527,
0.08853875,
0.010400474,
-0.025004249,
-0.0050823563,
-0.0058098505,
-0.00620391,
0.012461709,
0.017405976,
0.0052271816,
-0.049873777,
0.016247373,
0.014522943,
0.01174095,
-0.026311046,
-0.027698673,
0.023899537,
-0.01199692,
0.007813828,
-0.035728056,
-0.0147654405,
0.032360025,
-0.0125762215,
0.0164764,
0.017877499,
-0.013579894,
-0.014576831,
0.0313092,
-0.01666501,
0.0058199544,
-0.03141698,
0.0032383602,
0.011006719,
-0.029045885,
-0.022996904,
0.024883,
-0.01794486,
-0.003987747,
-0.0010828214,
0.0077599394,
0.002756732,
-0.0014406745,
0.03742554,
-0.022713989,
-0.0011375519,
-0.0011796523,
-0.008191047,
-0.015870154,
-0.009033054,
-0.025502717
] |
Expression from both alleles is generally observed in analyses of diploid cell populations, but studies addressing allelic expression patterns genome-wide in single cells are lacking. Here, we present global analyses of allelic expression across individual cells of mouse preimplantation embryos of mixed background (CAST/EiJ × C57BL/6J). We discovered abundant (12 to 24%) monoallelic expression of autosomal genes and that expression of the two alleles occurs independently. The monoallelic expression appeared random and dynamic because there was considerable variation among closely related embryonic cells. Similar patterns of monoallelic expression were observed in mature cells. Our | [
-0.038357,
0.00016202175,
-0.013522468,
-0.04207568,
-0.03606858,
0.00789244,
-0.02170096,
0.005074176,
-0.028501201,
-0.01583689,
-0.0120466985,
0.009615255,
0.01568086,
-0.0014465139,
-0.012261238,
0.023157226,
0.03162177,
0.007775419,
0.0038617048,
0.01566786,
-0.0345343,
0.020153677,
0.0008662831,
-0.024210418,
-0.009628257,
0.020023653,
0.01556384,
-0.025965739,
-0.014926724,
-0.0389031,
0.003556149,
0.008263008,
-0.01895746,
-0.019191502,
-0.005295216,
-0.0011076396,
0.005139188,
0.0055032545,
0.032271888,
0.008913127,
0.015407812,
0.008718091,
-0.024665501,
-0.0037999435,
0.010421402,
0.0031595766,
-0.004290783,
-0.0061013633,
0.008848115,
0.018177317,
-0.00197311,
0.016734054,
-0.024951553,
0.003929967,
-0.035704516,
-0.00091910525,
-0.010987005,
0.006224886,
-0.016903084,
0.008685585,
-0.0003079937,
0.0011092649,
-0.0235603,
0.013073886,
-0.021492923,
-0.013704501,
0.006533692,
0.0088546155,
0.02038772,
-0.0068847565,
0.018840438,
-0.01687708,
-0.01238476,
-0.011916675,
0.0066442126,
-0.012469276,
-0.006127368,
0.01457566,
-0.011169039,
0.015823888,
0.014133579,
-0.0014123827,
0.008776601,
0.023586305,
0.00317908,
0.009959818,
0.0011303938,
0.019685593,
0.00032973205,
-0.00964126,
0.013938543,
0.021882994,
0.006442676,
0.0046255942,
-0.008048469,
-0.016070932,
-0.0026167275,
0.03024352,
-0.010993506,
-0.03736882,
0.007703906,
0.006341907,
-0.013028378,
-0.01265781,
-0.030399548,
0.017111123,
0.013028378,
0.007989958,
0.01737117,
-0.015420814,
-0.011988188,
0.010388896,
0.035418462,
-0.025939735,
0.024951553,
-0.000302102,
0.0038096951,
-0.016760059,
-0.010232868,
0.012781332,
0.010369392,
0.028969286,
0.010694452,
-0.016903084,
0.02766905,
0.050995305,
-0.026654864,
0.0030116746,
-0.011851663,
0.0023761836,
0.013678496,
0.001984487,
0.020114671,
0.024808528,
-0.020699777,
-0.01655202,
-0.011266556,
0.011156036,
0.003419624,
-0.029489381,
0.0002153518,
0.015498828,
-0.014224596,
0.010226366,
0.01747519,
0.031049667,
0.019412542,
-0.010232868,
0.021596942,
0.0012189725,
0.0016098563,
-0.010908991,
0.033078037,
-0.0034066217,
0.012215729,
0.020673772,
0.016578026,
0.023417274,
-0.027721059,
0.010434404,
-0.008067972,
0.00069237634,
-0.002460699,
0.021076847,
0.012651308,
0.03393619,
0.0030929395,
0.001062944,
-0.016148947,
-0.030919643,
-0.030217515,
0.0055000037,
-0.025770703,
0.01216372,
-0.0025614675,
-0.00784043,
-0.005327722,
-0.0010540049,
-0.029931461,
-0.023807345,
0.0020299954,
0.02504257,
0.009615255,
-0.009036649,
-0.0055487626,
-0.007222818,
0.02564068,
-0.0054317415,
0.0070862933,
-0.014289607,
-0.003331858,
0.0029564146,
0.0052367058,
0.0014083195,
-0.65282315,
-0.009082157,
0.007801424,
-0.0032798485,
-0.002789009,
0.04103549,
0.00054772495,
-0.006241139,
-0.025055572,
0.010148352,
-0.021713963,
0.008672583,
0.020036656,
-0.024665501,
-0.0131584015,
-0.023378266,
0.004723112,
-0.035912555,
0.020803796,
-0.0023371766,
-0.01759221,
0.0041900147,
-0.0056267767,
0.01610994,
-0.009940314,
0.026043752,
0.014393627,
-0.005044921,
-0.022650134,
0.03651066,
-0.02509458,
0.007846932,
-0.031803805,
-0.0059258314,
0.04334991,
0.01457566,
0.012787834,
0.01802129,
-0.006104614,
0.047198612,
0.0061078644,
0.007814426,
0.0131584015,
0.00230142,
-0.0044240574,
0.024665501,
-0.0029011543,
0.00657595,
0.014601665,
-0.018723417,
-0.025731696,
0.00520745,
-0.02476952,
-0.0072358204,
0.010096342,
0.015797883,
0.03497638,
0.010609936,
0.029749429,
-0.005080677,
-0.0036666691,
0.006146872,
-0.007801424,
-0.0036081586,
0.007573882,
-0.0057112924,
-0.005665784,
-0.013847527,
-0.011377077,
0.008724593,
0.0023160477,
0.038304992,
-0.007716908,
0.007677901,
0.009472229,
0.018931454,
0.00022327511,
-0.00784043,
-0.009992324,
0.018866442,
-0.018177317,
0.0071773096,
-0.01912649,
0.0054805,
0.025510656,
-0.008997642,
-0.0023583053,
0.035496477,
-0.0039039624,
-0.0017081867,
0.014562658,
0.008087476,
0.0121572185,
-0.042595774,
-0.01529079,
0.01802129,
-0.013886535,
0.010635941,
0.024418456,
-0.020751787,
-0.024158409,
-0.024613492,
0.01748819,
-0.005376481,
-0.0005769803,
0.020517744,
-0.031101676,
-0.0024964556,
0.02635581,
-0.0039982297,
-0.0026102264,
-0.0019211005,
-0.0016756807,
-0.006254141,
-0.0041997666,
-0.024288433,
-0.0006903447,
0.015485826,
-0.017566206,
-0.013522468,
0.006072108,
-0.01035639,
-0.00048596368,
-0.0072293193,
0.008230502,
-0.01085048,
-0.0072293193,
-0.024899544,
0.008295514,
0.0028101378,
0.0058868243,
0.00028463008,
0.009959818,
-0.024600489,
0.03128371,
-0.011357573,
0.010928494,
0.001076759,
0.010421402,
-0.020413725,
-0.016838074,
0.0062281364,
-0.0024964556,
-0.0009694894,
0.00089066254,
-0.0012742325,
-0.036016572,
-0.0043817996,
0.0060591055,
-0.012391262,
0.010369392,
0.0235603,
-0.009400715,
0.02635581,
0.002038122,
-0.011338069,
-0.013613485,
-0.026732879,
-0.0012620428,
-0.019607577,
0.0072683264,
0.0071057966,
0.0045508305,
-0.010876485,
-0.0061338693,
0.0045898375,
-0.026784888,
0.00065215025,
0.003244092,
-0.017397175,
-0.014276605,
-0.0059193303,
0.0073138345,
0.01003133,
-0.0022786658,
0.008796105,
-0.006614957,
0.0069432673,
-0.0015879148,
-0.024574485,
0.007573882,
-0.015953911,
-0.022559118,
-0.024132404,
0.039865274,
0.014835708,
0.027539026,
-0.0028751497,
0.0073073334,
0.012150717,
0.0045638327,
0.022702143,
-0.018385354,
0.027851082,
0.014198591,
-0.0059908433,
-0.0024558231,
0.004290783,
0.013925541,
0.03502839,
0.019087484,
0.0064524277,
-0.0043167877,
-0.01912649,
0.021141859,
-0.044026036,
-0.008692087,
-0.0029027797,
0.011500599,
-0.007989958,
0.0025175845,
0.002038122,
-0.0078534335,
-0.015901903,
-0.010557927,
0.0037121775,
-0.012755328,
-0.015199774,
0.01655202,
-0.0007147242,
-0.0067742364,
0.031985838,
0.020335712,
0.009095159,
0.0027695054,
-0.002543589,
0.0017910769,
0.0133014275,
0.008204497,
-0.0020706279,
0.0018528381,
0.020309707,
0.0016740555,
-0.00004375603,
0.013704501,
0.011403081,
0.02262413,
-0.013106392,
0.029411368,
0.011240551,
-0.009771283,
0.023313254,
0.0018837188,
0.034404278,
0.007807925,
-0.015251784,
0.023105217,
0.017215142,
-0.01568086,
0.017384173,
0.010102844,
0.0085685635,
-0.010206862,
0.0065011866,
0.0019471053,
0.010564428,
0.0038064446,
0.015225778,
0.033520117,
0.014484643,
0.008867619,
0.0010913867,
0.0014668301,
-0.009036649,
-0.019750604,
-0.009238186,
-0.003024677,
-0.009459226,
0.007365844,
-0.009036649,
-0.02865723,
-0.008471046,
0.041243527,
-0.0047198613,
0.00088253606,
0.018918453,
-0.0021925252,
0.010167856,
0.043167878,
0.004892143,
-0.030919643,
-0.02821515,
0.034378275,
0.026914911,
-0.009186177,
-0.023430277,
0.0074048513,
-0.014484643,
0.0008679084,
0.010876485,
0.021193868,
0.012807338,
0.010720456,
-0.00750887,
-0.023716329,
-0.03391019,
0.030919643,
-0.010668447,
0.020413725,
-0.0064524277,
0.011162537,
-0.0044565634,
-0.009283694,
-0.0068587516,
0.050371192,
0.005113183,
0.00046239689,
-0.01945155,
0.0009808665,
-0.02865723,
-0.01934753,
-0.029567396,
-0.013964549,
-0.0014619543,
0.0044435607,
-0.022338077,
-0.008087476,
0.019516561,
0.0334161,
-0.0018495875,
-0.01616195,
-0.01726715,
-0.0001682182,
0.0117281405,
0.015355802,
0.02274115,
-0.014679679,
0.012638306,
-0.010564428,
-0.002559842,
-0.025718693,
-0.01287885,
0.017605213,
-0.0120466985,
-0.02712295,
0.0046288446,
-0.009543742,
-0.0044403104,
0.004944152,
0.019984648,
-0.0013498089,
-0.021089848,
-0.008776601,
0.026004747,
-0.008067972,
-0.012846344,
0.03424825,
0.028969286,
0.014588662,
-0.0026102264,
0.023651317,
0.011071521,
-0.011539605,
-0.011175539,
-0.005239956,
0.02153193,
0.01633098,
0.008510053,
0.009719274,
-0.012631806,
0.0013758136,
0.017878262,
0.0046125916,
-0.0034423782,
0.016578026,
0.0057990584,
-0.011325067,
-0.007281329,
0.0017959528,
-0.021167863,
-0.0098232925,
0.013548473,
-0.003884459,
-0.015589845,
0.020010652,
-0.02608276,
0.014172587,
-0.017345166,
-0.004011232,
0.021193868,
-0.01895746,
-0.011955682,
0.0030279276,
-0.00032973205,
0.0072293193,
-0.016174952,
0.009166673,
0.0022282817,
-0.01556384,
-0.013769513,
-0.003916965,
-0.0095372405,
-0.022312071,
-0.025783705,
0.004849885,
-0.02422342,
-0.02306621,
-0.016018923,
0.016591027,
0.025562664,
0.0060526044,
-0.011188542,
-0.0045475797,
0.03528844,
-0.014289607,
-0.018671408,
-0.011962183,
-0.04504022,
-0.022052024,
0.008295514,
-0.0045053223,
-0.01660403,
-0.02487354,
0.002576095,
0.004203017,
-0.018489374,
-0.0019487307,
-0.016096938,
-0.018424362,
0.03320806,
0.0058770725,
0.01068795,
-0.005825063,
-0.026602855,
0.010174356,
-0.03856504,
-0.024119401,
-0.02618678,
-0.022156043,
-0.028995292,
-0.017384173,
0.0054382426,
0.0022055274,
-0.0058868243,
-0.015160766,
-0.0033838674,
0.008685585,
0.013925541,
0.014211593,
0.018385354,
-0.011949181,
0.00020905377,
-0.00619238,
-0.0053407247,
0.018970462,
-0.01638299,
0.027825078,
0.013028378,
-0.025796708,
0.032245886,
-0.038122956,
-0.01895746,
-0.009322701,
0.008614072,
0.007684402,
0.03983927,
0.0022201552,
-0.025289616,
-0.008828611,
0.0035951561,
-0.010089842,
0.012508282,
0.0041022487,
0.0056982897,
-0.018606396,
0.011994689,
-0.0010345012,
-0.02170096,
0.0058153113,
-0.043974023,
0.008698587,
0.0147967,
-0.019698596,
0.009381212,
0.0066344608,
0.012807338,
0.008191495,
-0.0028556462,
-0.028579215,
-0.047718707,
0.025770703,
-0.013457456,
0.05281564,
0.011500599,
0.021765972,
0.0074048513,
0.0031319465,
0.027851082,
-0.000678155,
0.0028930278,
-0.002481828,
0.034274254,
0.005122935,
0.02307921,
0.012813838,
0.021557935,
0.014835708,
0.0026996178,
0.027903093,
0.026615858,
-0.020686775,
-0.017332163,
0.021922,
-0.013086888,
-0.036094587,
0.012748826,
-0.0007480428,
-0.0021080098,
-0.012365256,
-0.0006980649,
0.03058158,
-0.013561475,
0.008126483,
0.004203017,
0.02229907,
-0.014107575,
0.029827444,
-0.029541392,
-0.015199774,
-0.012313247,
-0.018281337,
-0.014419631,
0.0029986722,
0.028995292,
0.015056748,
0.02701893,
0.012287242,
-0.018008286,
0.0054447437,
0.011292561,
-0.038929105,
0.016343983,
-0.017189138,
-0.023430277,
-0.006614957,
-0.0186324,
-0.023456281,
-0.016487008,
0.003348111,
0.0120466985,
-0.0023534296,
0.024860537,
0.0018122058,
-0.035964563,
-0.0025338375,
0.008542559,
0.045664333,
-0.018307341,
0.017293155,
0.023872357,
-0.0064524277,
-0.033962198,
-0.024522476,
0.0058218124,
0.0068847565,
0.02284517,
0.007937948,
-0.010980504,
-0.0116176205,
-0.0012912982,
-0.0052854647,
-0.014315613,
-0.016278971,
0.0022266563,
-0.0027077443,
-0.006728728,
-0.0153428,
0.0069562695,
-0.015316796,
0.012209228,
-0.02707094,
0.0058153113,
-0.013769513,
-0.016617032,
-0.01900947,
0.0055325096,
0.0015383433,
0.0057958076,
-0.0020527495,
0.0067742364,
0.010161354,
-0.0054317415,
-0.009082157,
0.012742326,
-0.0023664318,
0.031101676,
-0.02619978,
0.0133014275,
0.009569746,
0.002619978,
-0.01320391,
-0.008906625,
-0.005890075,
0.04147757,
-0.0356005,
0.004307036,
0.004810878,
0.012508282,
0.007489367,
0.011130031,
-0.021011835,
-0.014718686,
-0.01802129,
0.0013335559,
0.047484666,
0.006728728,
-0.00054406805,
-0.016773062,
-0.034560308,
-0.0029255338,
-0.035808533,
-0.040671423,
0.015602848,
-0.040047307,
0.010785468,
0.01304138,
0.018931454,
0.04251776,
0.009101661,
0.0047978754,
-0.0044923197,
0.005135937,
-0.007502369,
0.029619405,
0.00078501826,
0.0047361143,
-0.025341624,
0.018060297,
-0.0022234058,
-0.01457566,
0.0014635796,
-0.02608276,
-0.006702723,
-0.012885352,
0.008041968,
0.010980504,
-0.005451245,
-0.006839248,
-0.008737595,
0.015940908,
0.032089856,
0.0019032223,
-0.0028426438,
-0.0020673773,
-0.01858039,
-0.0121572185,
0.011669629,
0.011812655,
-0.014198591,
0.0017504444,
-0.020673772,
0.016369987,
-0.0011685883,
-0.0073333383,
-0.028371178,
0.007963954,
0.002016993,
0.0044695656,
-0.016421996,
-0.018281337,
-0.013613485,
0.03682272,
0.0076193903,
-0.018593393,
-0.026290799,
0.0091081625,
0.011591615,
0.029567396,
0.006283397,
0.0015838515,
-0.0037284305,
-0.032193877,
-0.027435007,
0.016291972,
0.0025127085,
0.037836906,
0.028345173,
-0.0070017776,
-0.02006266,
0.011637123,
-0.02328725,
-0.03588655,
0.011104027,
0.014705684,
0.0014912096,
0.02855321,
0.0027532524,
0.00018528382,
0.008061471,
0.010713955,
-0.041061494,
-0.026238788,
0.02006266,
-0.031101676,
0.0041932655,
0.012183223,
-0.015498828,
-0.018645402,
0.011312065,
-0.014536653,
-0.020972827,
0.024756517,
-0.012072703,
0.03128371,
-0.0140165575,
0.016226962,
0.0046288446,
0.010089842,
0.027278978,
-0.022065027,
-0.018177317,
0.014068567,
0.006510938,
-0.008939131,
0.012748826,
-0.00958925,
0.01780025,
-0.0074503594,
-0.04223171,
-0.012150717,
0.00969977,
-0.016630035,
-0.01211171,
0.015771879,
-0.004323289,
-0.002125888,
0.0029044051,
0.0072293193,
-0.008848115,
-0.028761249,
-0.0018008286,
0.0017195639,
0.008958635,
0.0135874795,
-0.008113481,
0.004339542,
-0.006514189,
-0.020257697,
0.0037284305,
-0.009654262,
-0.0060070963,
-0.014250601,
0.009725775,
0.013047881,
-0.027435007,
-0.0020641268,
-0.0046093413,
-0.016864078,
-0.025822712,
0.012371758,
0.006374413,
-0.017943274,
-0.0061891293,
-0.006426423,
-0.003786941,
-0.010492915,
0.0052139517,
-0.0010775717,
-0.021505924,
0.025835715,
0.17964078,
-0.04400003,
0.0047361143,
0.003320481,
-0.015966915,
-0.04543029,
0.008536058,
-0.0025062074,
-0.003952721,
0.0060461033,
0.0069822744,
0.0058315643,
-0.019659588,
0.008035466,
0.024509473,
-0.0022656634,
-0.012196226,
0.0009816792,
-0.029931461,
0.0013075512,
0.008627075,
-0.03237591,
0.0098232925,
0.0034456288,
0.021869991,
0.012007691,
-0.025991743,
-0.003803194,
0.0021990263,
-0.005506505,
-0.024431458,
0.012150717,
0.006624709,
-0.0060916115,
-0.0015269661,
0.012950364,
-0.0019812365,
0.011786651,
0.007989958,
-0.0064914348,
-0.019074481,
0.0044923197,
-0.0002913344,
-0.008796105,
0.005513006,
0.0065011866,
0.0036699197,
-0.021961007,
-0.010726958,
-0.017787246,
-0.031491745,
0.035262436,
-0.008646578,
0.03193383,
0.0059420844,
-0.015576842,
0.026563847,
-0.0043265396,
-0.009465727,
0.041841637,
0.0010564427,
0.010661946,
-0.03260995,
0.0043427926,
-0.0013229914,
0.024158409,
0.013821523,
-0.004651599,
-0.0008524681,
-0.036250614,
0.020023653,
-0.015277788,
-0.018177317,
0.001994239,
0.0010759464,
-0.005018916,
0.035054397,
0.0416336,
0.0121897245,
0.008685585,
0.02252011,
-0.0045638327,
-0.015355802,
0.011942679,
-0.019542566,
-0.035808533,
0.03117969,
0.011357573,
-0.016526015,
-0.017735237,
0.0035528983,
-0.017189138,
-0.013782515,
-0.01293086,
0.01670805,
-0.010401898,
0.0107919695,
0.009498233,
-0.019750604,
-0.033676147,
-0.013860529,
0.05003313,
0.00756088,
0.01764422,
-0.001370125,
0.014393627,
-0.004072993,
-0.01737117,
-0.017670225,
0.013177905,
0.0044858186,
-0.017930273,
0.023846352,
-0.0008646578,
-0.002992171,
0.0053017177,
0.0208168,
-0.042387735,
0.04509223,
-0.00009507985,
-0.02252011,
-0.02229907,
0.0005148127,
0.02006266,
-0.00257447,
0.014354619,
-0.029957468,
0.03424825,
-0.001885344,
-0.022546114,
-0.029853448,
0.0052529587,
0.021817982,
0.021440912,
0.017436182,
-0.02306621,
-0.0058803232,
-0.015641855,
-0.038513027,
-0.003107567,
0.0018219575,
-0.018788429,
0.006442676,
0.008171991,
0.009368209,
-0.014211593,
0.025003564,
0.022767154,
-0.026251791,
-0.008731093,
-0.01704611,
-0.010070338,
-0.013899537,
0.00022632255,
0.024912545,
-0.015745873,
-0.0025013315,
-0.011351071,
-0.015576842,
0.0057763043,
-0.0055910205,
0.012176722,
-0.0016968097,
0.0032538439,
0.005103431,
-0.005490252,
-0.16268569,
-0.00018396326,
-0.010492915,
-0.013281924,
0.0123002445,
0.020946823,
0.0009898057,
-0.011273057,
0.0033578628,
-0.0006976586,
0.026056755,
0.00013540752,
-0.030321533,
-0.013275423,
0.022975193,
0.015251784,
-0.020699777,
0.043531943,
0.024938552,
0.0032749726,
0.04423407,
-0.016421996,
0.030763615,
-0.0070602885,
-0.0025517156,
0.0037836905,
0.0017423179,
-0.002449322,
-0.0110780215,
-0.030477561,
-0.011240551,
0.032557942,
0.009342205,
0.0069887755,
0.013639489,
-0.015264786,
-0.03775889,
0.00071391155,
-0.0027435008,
0.0024184412,
0.045066223,
0.036380637,
-0.016174952,
-0.009504735,
-0.005009164,
0.032401912,
-0.020036656,
-0.0202707,
0.028761249,
0.009881804,
0.007677901,
-0.0046841046,
0.0043297904,
0.010395397,
0.035470475,
0.021739967,
0.021778975,
0.03193383,
-0.0056820367,
0.0055325096,
0.0059420844,
-0.019113488,
0.029801438,
0.0011263306,
0.013743508,
-0.002493205,
-0.015264786,
0.027877087,
-0.025718693,
-0.008796105,
-0.034456287,
-0.0056397794,
0.019022472,
-0.03458631,
0.031829808,
0.0059095784,
0.0089651365,
0.002964541,
0.023261245,
-0.02180498,
-0.03627662,
0.015498828,
-0.017722234,
0.002026745,
-0.0065239407,
0.006250891,
0.0018284586,
0.0120141925,
-0.014991736,
-0.006432924,
0.02619978,
-0.001257167,
-0.0128723495,
-0.017631218,
0.0089651365,
0.008158989,
-0.002093382,
-0.005490252,
-0.0012295368,
-0.0055552637,
0.017124126,
-0.026966922,
-0.02564068,
0.0030019227,
0.028839262,
-0.013184406,
-0.010180858,
0.008295514,
0.043896012,
-0.0133014275,
-0.018151313,
0.009407217,
-0.008503552,
0.024587488,
0.008451542,
0.027513022,
-0.011240551,
-0.005457746,
0.0026979924,
-0.028371178,
0.061787277,
-0.0115070995,
-0.008126483,
0.016747056,
0.011390079,
-0.0021226374,
-0.12336651,
-0.025237605,
0.0060200985,
-0.003161202,
-0.0057242946,
0.023482285,
-0.01484871,
0.03651066,
-0.02115486,
0.045898378,
-0.028267158,
-0.0061566234,
-0.009998824,
-0.012781332,
0.022221055,
0.0032473425,
0.004778372,
0.0022754152,
-0.030087491,
0.03435227,
0.0020088665,
0.018567389,
0.013769513,
-0.01791727,
0.011305563,
0.00089310046,
-0.034482293,
0.041243527,
0.007112298,
0.0034553807,
-0.0011003258,
-0.013138898,
0.0017894516,
-0.00028970913,
-0.011539605,
-0.011845161,
-0.016044928,
-0.023001198,
0.024197416,
0.007911944,
-0.012007691,
0.014458639,
-0.013223413,
-0.00613712,
-0.0043622963,
0.0040632416,
0.0019145994,
0.002428193,
-0.008523055,
-0.028943282,
-0.031803805,
-0.020504743,
-0.013665494,
-0.012280741,
0.011838661,
0.0013571227,
-0.008497051,
-0.0003750372,
-0.006657215,
-0.0084255375,
0.008360526,
-0.016994102,
-0.011936178,
-0.006098113,
0.018372353,
-0.022676138,
-0.010200362,
-0.013782515,
0.016018923,
-0.03167378,
-0.03058158,
0.02180498,
0.013021876,
-0.005028668,
-0.02422342,
0.008119982,
-0.016916087,
-0.0134444535,
0.021882994,
-0.0019487307,
-0.011533105,
-0.023963373,
0.023937369,
-0.024093397,
0.027096946,
0.005265961,
0.0069887755,
-0.014497646,
-0.013138898,
-0.010908991,
-0.033520117,
0.030191509,
0.007729911,
-0.026732879,
-0.035080403,
0.0035073902,
-0.0020348714,
-0.0021567687,
0.0149527285,
0.009498233,
-0.018164314,
-0.005178195,
-0.04423407,
0.0029222833,
-0.020907816,
-0.008406034,
0.007294331,
-0.017059114,
0.019776609,
-0.007677901,
-0.008412535,
0.01759221,
-0.014198591,
-0.007749414,
-0.017826254,
-0.006426423,
-0.01430261,
-0.0056202756,
0.01090249,
0.010401898,
0.019412542,
0.038669057,
-0.003929967,
-0.012644808,
0.0023436777,
0.008835113,
-0.021609943,
-0.015446819,
-0.031413734,
0.0138735315,
-0.00958925,
-0.011377077,
-0.0059875925,
-0.027278978,
-0.0035789032,
0.019100485,
-0.01660403,
-0.015823888,
0.026030751,
0.03260995,
0.017410178,
0.015433816,
-0.030087491,
-0.014263603,
0.017891265,
0.011793152,
-0.020998832,
0.00800296,
-0.036640685,
0.0061013633,
0.00037828778,
0.0076193903,
0.05086528,
-0.0011824033,
0.0110780215,
-0.028449193,
-0.01238476,
-0.0069627706,
-0.012976368,
0.01046691,
0.0042550266,
-0.017930273,
0.029931461,
0.020998832,
0.021791976,
-0.002433069,
-0.0017146879,
0.00061314314,
-0.020101668,
0.0054057366,
-0.011799653,
-0.026888907,
-0.020218689,
-0.0068522505,
0.008178492,
0.0071187993,
0.0034131228,
0.0019877378,
-0.00033887435,
0.027695054,
-0.008802607,
0.01824233,
0.018554386,
-0.004131504,
-0.003913714,
0.016968096,
0.026888907,
0.0030328035,
-0.013229914,
0.012631806,
-0.010096342,
-0.00049855973,
-0.001400193,
0.015992919,
-0.009153671,
0.02509458,
0.01692909,
0.026316803,
-0.0121572185,
0.006319153,
0.005239956,
0.032089856,
0.015420814,
0.0065726996,
0.005174944,
-0.030191509,
-0.012579796,
0.021948006,
-0.034170236,
-0.02855321,
-0.019607577,
0.0059388336,
0.0017715733,
0.014510648,
-0.021349896,
-0.0045313267,
-0.01704611,
0.0018333346,
0.017787246,
-0.011357573,
-0.02153193,
0.046470482,
0.004843384,
-0.0045605823,
0.011923176,
-0.0146666765,
0.013691499,
-0.011338069,
0.027955102,
-0.01759221,
0.0056852875,
-0.018203322,
0.040645417,
0.016369987,
0.00013622017,
-0.016565023,
-0.0035301442,
-0.000021700249,
0.004290783,
0.033624135,
-0.0059908433,
0.08061471,
0.0049344003,
-0.0062378882,
0.026888907,
-0.016122943,
0.03346811,
0.018970462,
0.02164895,
0.006143621,
-0.040229343,
0.010817974,
-0.040853456,
0.041009486,
-0.028943282,
-0.007638894,
0.018892448,
-0.015433816,
-0.014627669,
-0.028293163,
-0.017839255,
0.025692688,
-0.02432744,
0.00619238,
0.03034754,
-0.04360996,
-0.009140668,
0.039267167,
0.014341617,
-0.004957155,
0.0019649835,
0.008880621,
-0.031907823,
-0.043011848,
0.0037414327,
-0.00005566641,
-0.01682507,
0.025874723,
-0.017397175,
0.0089651365,
-0.012631806,
-0.01616195,
-0.0014278231,
0.0026541094,
-0.0027825078,
0.025614675,
-0.007788421,
-0.014835708,
0.0070927944,
-0.025120584
] |
Macrophages produce a large amount of PGE(2) during inflammation. This lipid mediator modulates various immune responses. PGE(2) acts on macrophages and inhibits production of cytokines such as TNF-alpha and IL-12. Membrane-bound glutathione-dependent PGE(2) synthase (mPGES) has been shown to be a terminal enzyme of the cyclooxygenase-2-mediated PGE(2) biosynthesis. Here we identified mPGES as a molecule that is induced by LPS in macrophages. The expression of mPGES was not induced by LPS | [
-0.016687848,
-0.0063034315,
-0.015869051,
-0.040315967,
-0.031166244,
0.0038242983,
-0.016609866,
0.032128006,
-0.011157723,
-0.014725336,
0.023485156,
0.017259706,
-0.002820298,
0.004483884,
-0.0069532697,
0.018052507,
0.03584508,
0.012613362,
-0.0018227964,
0.00016834874,
-0.0067908103,
0.01012448,
0.000098795725,
-0.02447291,
0.0028722852,
0.01723371,
0.00085859885,
-0.049959566,
-0.036416937,
-0.005367664,
-0.0005470826,
-0.014400417,
-0.025330696,
0.027995033,
0.00063602923,
-0.01442641,
0.029944548,
-0.009006759,
0.014881297,
-0.004175211,
0.020755835,
-0.0023816573,
0.009832053,
0.0056081046,
0.015297193,
-0.0046755867,
0.008376416,
-0.008636351,
-0.019040262,
0.011846552,
0.02539568,
-0.006836299,
0.014803316,
-0.0006173464,
-0.013698591,
-0.0046365964,
-0.0080969855,
0.0030152497,
0.0003427897,
-0.037144758,
-0.014842306,
-0.023914048,
-0.023901053,
-0.007518629,
0.0026952042,
0.019469155,
-0.009377167,
0.02310825,
-0.0037398194,
-0.009461646,
0.02752715,
0.04790608,
-0.0026692108,
-0.011918034,
0.0034278969,
-0.016609866,
-0.046112526,
-0.0032784343,
0.0018049259,
0.0047210753,
0.028099008,
-0.014439407,
0.001213573,
0.02981458,
0.011281192,
-0.017051756,
0.0075251274,
0.018143484,
0.003834046,
-0.02097678,
0.026474413,
0.027709104,
0.032569896,
0.026929298,
-0.015856054,
0.023355188,
0.011118733,
0.016310941,
-0.008135975,
-0.027267214,
-0.008499885,
0.006462642,
-0.008428402,
-0.021834567,
-0.04819201,
-0.0058485446,
-0.012645853,
-0.015102242,
0.02937269,
0.01362061,
-0.0067583183,
0.045384705,
0.000073309886,
-0.043175258,
0.0054034055,
0.002118473,
0.020560883,
0.00018297009,
0.0068298005,
-0.0063034315,
-0.006654344,
0.019001272,
0.016219964,
-0.00076599687,
0.028982788,
-0.0023800328,
-0.015375174,
-0.01788355,
-0.03886033,
0.023914048,
0.0049160267,
0.024355939,
0.006784312,
-0.00699226,
-0.024057014,
-0.0005828237,
-0.032595888,
-0.0016449032,
-0.0065081306,
-0.02929471,
0.01129419,
0.03724873,
-0.002514874,
0.02660438,
0.006569865,
0.02841093,
0.026695358,
0.017155731,
-0.014725336,
0.019495148,
-0.0073366743,
-0.026669364,
0.007414655,
-0.002077858,
0.0019560133,
-0.0032102012,
-0.005773813,
0.031140251,
-0.012905789,
-0.019235214,
0.015882049,
-0.027943047,
0.02193854,
0.010338928,
0.01261986,
0.03332371,
0.014335433,
0.036105014,
-0.011034254,
-0.004214201,
-0.004938771,
0.02274434,
-0.0196901,
0.03945818,
-0.00743415,
0.03620899,
-0.011768571,
0.011170721,
0.027371189,
-0.027189234,
-0.0057250755,
-0.0043376707,
0.011027756,
-0.001374408,
-0.017025763,
-0.018065505,
0.031088265,
-0.012548378,
0.004584609,
-0.024966788,
-0.0006339985,
0.028358944,
-0.001518997,
-0.045670636,
-0.62841964,
-0.025421673,
0.009929529,
-0.007518629,
-0.00827894,
0.032179993,
-0.0041329716,
-0.014842306,
-0.019898048,
0.02958064,
-0.0052831853,
0.033453677,
0.017701594,
-0.008155471,
0.002745567,
-0.031686116,
-0.03982209,
-0.016310941,
0.015128235,
0.00044351464,
0.0019267706,
-0.026318451,
-0.008753322,
0.015024262,
0.0007095422,
0.02355014,
0.03436345,
-0.008012506,
-0.0021655862,
0.06129275,
-0.018208468,
0.020950787,
-0.019196223,
-0.015544132,
0.045904577,
0.009832053,
-0.020703848,
0.034753352,
0.016012015,
0.01434843,
-0.039510168,
-0.024044016,
-0.011911536,
-0.019937038,
-0.022211473,
0.036754854,
0.01748065,
0.023407176,
-0.0103129335,
0.0046788356,
0.0035578646,
0.0038275477,
0.006901283,
0.011437154,
0.01840342,
0.015115239,
0.02069085,
-0.0074406485,
0.009884041,
0.01965111,
0.010644351,
0.036832836,
0.014777322,
-0.009409659,
-0.021886554,
0.0072586937,
-0.014855304,
-0.032725856,
0.006514629,
0.032128006,
0.016622864,
0.021119744,
0.002535994,
0.005773813,
0.005754318,
0.026058516,
-0.0044643893,
0.020313945,
-0.009305684,
0.017350683,
0.010624856,
0.00043701625,
-0.021002773,
0.013880546,
0.027345195,
0.00051743374,
-0.015063251,
0.0036293468,
-0.0033791591,
-0.015804067,
0.018338436,
0.0132631995,
-0.035975046,
-0.031842075,
-0.03298579,
0.026903305,
-0.008012506,
0.019482153,
0.022731343,
-0.016661854,
-0.027995033,
-0.0013191717,
0.0067973086,
0.00017850245,
0.046112526,
0.001510874,
-0.05536622,
-0.01261986,
0.052740876,
-0.025031772,
0.021769583,
0.00875982,
0.002716324,
-0.039770104,
0.0038210491,
-0.01980707,
0.010507885,
0.0045911074,
-0.005682836,
-0.0249148,
0.017714592,
-0.010956273,
0.0086103575,
0.009006759,
0.009500636,
0.020287951,
-0.012593866,
-0.021652611,
0.0017253207,
0.0011087866,
0.0012866798,
0.013412663,
0.018221466,
-0.00827894,
0.01627195,
0.028774839,
0.04762015,
0.015518138,
-0.009429154,
-0.043383203,
-0.018195473,
0.0040030037,
0.008122979,
-0.0062027066,
0.0040972303,
0.00046422824,
-0.0014596992,
0.011164222,
0.01479032,
0.009630604,
0.0026659616,
-0.0047113276,
0.0019072754,
0.0059460206,
0.0393802,
-0.006738823,
-0.008304933,
0.0034311463,
-0.003070486,
-0.002860913,
-0.005952519,
0.0054229004,
-0.010403911,
0.0052506933,
-0.034545403,
-0.008714331,
0.0040809843,
0.013321685,
-0.009422655,
-0.031114258,
-0.0078110565,
-0.008155471,
-0.013685594,
0.0055918586,
0.0049420204,
0.008662345,
0.004802305,
-0.01221696,
0.0013849678,
0.0010649225,
0.014114488,
0.009533128,
0.011138229,
0.007083237,
0.025031772,
0.009598112,
0.011203212,
0.0054943827,
0.0045911074,
0.029892562,
-0.018663356,
0.02069085,
-0.010462397,
0.016102992,
0.018611368,
-0.023979032,
-0.0032524406,
0.00538391,
0.0043214248,
0.023940044,
-0.012281944,
-0.03464938,
0.0006214079,
-0.014322436,
0.005923276,
-0.03480534,
-0.0037950557,
-0.01627195,
0.025447667,
0.0036455928,
-0.0035773597,
-0.01185305,
-0.0052344473,
-0.003206952,
0.005400156,
0.01137217,
0.0088053085,
-0.0117880665,
0.020391926,
-0.027631124,
0.0137765715,
-0.01711674,
0.016622864,
-0.0030120006,
-0.03347967,
0.025018774,
0.014582371,
0.018338436,
-0.036182996,
-0.003215075,
-0.005634098,
-0.003392156,
-0.0046918327,
0.0024092754,
0.011469645,
0.01181406,
0.01884531,
0.0011258449,
0.04041994,
-0.0013484145,
-0.004041994,
0.014140481,
0.022432419,
-0.009825555,
-0.011703588,
0.002254939,
0.022094501,
-0.011021257,
-0.014439407,
0.019794075,
-0.0011177219,
0.019898048,
-0.006465891,
-0.0016562754,
-0.011183717,
0.0032296963,
0.0049420204,
0.021041764,
0.03709277,
0.004698331,
0.005936273,
-0.02013199,
-0.005822551,
-0.012009012,
-0.0028982789,
0.018234462,
0.013555626,
-0.0152841965,
-0.0076096063,
-0.026071513,
-0.043305222,
0.01350364,
0.021184728,
-0.033973545,
0.010065995,
-0.0034376446,
0.03568912,
-0.002522997,
0.015037258,
0.009143225,
-0.00085453736,
-0.019443162,
0.027839072,
0.010995264,
-0.016661854,
-0.016947784,
-0.026084509,
0.00061815867,
-0.0012395666,
0.007466642,
0.007980014,
0.009955523,
0.006192959,
0.0032378193,
-0.025291706,
-0.023095252,
0.01253538,
-0.0046235994,
0.01137217,
-0.0043246737,
0.00046544668,
0.014387419,
-0.0156741,
-0.002680583,
0.022315446,
0.00040513356,
-0.0047275736,
-0.024784833,
-0.010351924,
-0.029606633,
0.013802566,
-0.0046723373,
0.010475393,
-0.023498153,
-0.000070517606,
0.0036780848,
-0.020547887,
-0.002254939,
0.031738102,
0.00980606,
0.0027098258,
-0.049361717,
0.01659687,
-0.009598112,
0.0033661623,
0.024498904,
0.0057673147,
0.0010096863,
0.011638604,
0.0115606235,
-0.0027017028,
-0.02752715,
0.009351173,
-0.008506383,
-0.024420923,
0.006274189,
0.0015417413,
0.00032329455,
0.006261192,
0.00053733506,
0.017298695,
-0.0168828,
-0.0147383325,
-0.009617607,
0.025577635,
-0.009208209,
0.031816084,
0.01852039,
0.027709104,
-0.010559872,
0.00903925,
0.015024262,
-0.014075497,
-0.008103483,
-0.020599874,
-0.00041488113,
0.007707082,
-0.0023215474,
-0.0033157999,
-0.013016261,
0.0014645731,
-0.00413947,
0.021158734,
0.013386669,
-0.0061539686,
0.026214477,
0.00079077197,
-0.0050102533,
0.00093170564,
-0.011541128,
-0.00051743374,
0.023537142,
-0.017610617,
0.007278189,
0.03761264,
-0.022718348,
-0.015076248,
-0.023693103,
0.0180785,
-0.027475163,
-0.0066608423,
0.0014621362,
-0.007206707,
-0.012782319,
-0.0049485187,
-0.023290204,
0.009929529,
-0.026097506,
0.0070702406,
0.008571367,
0.0051337224,
-0.019924043,
-0.01920922,
-0.00502325,
0.018546386,
-0.0454107,
-0.040445935,
-0.008168467,
0.003970512,
0.010475393,
0.00023170796,
-0.0014548255,
-0.0037040783,
0.023316197,
-0.01796153,
-0.008454396,
-0.009838551,
-0.045904577,
0.014153478,
-0.0018260456,
0.014920287,
-0.010403911,
-0.019859059,
-0.013191718,
0.02575959,
-0.024901804,
0.017272701,
0.0045943568,
-0.03098429,
0.0048997807,
-0.000916272,
0.009383665,
-0.002740693,
-0.009669594,
-0.026669364,
-0.038184498,
-0.010598863,
-0.024303952,
-0.0042207,
0.007941024,
0.0013402915,
-0.004171962,
-0.011216209,
0.0036845831,
0.006280687,
0.0028869065,
-0.0049452693,
-0.008447898,
0.013373672,
0.026851319,
-0.004090732,
0.039718118,
0.0015969776,
-0.011359174,
-0.010351924,
-0.004516376,
0.011534629,
-0.0020388677,
-0.013373672,
0.0040354957,
-0.013133232,
-0.019053258,
0.0018601621,
0.005923276,
-0.015141232,
0.019027265,
0.0048282985,
-0.0061344733,
-0.01980707,
0.0031874569,
0.007733076,
0.011060248,
-0.011970022,
-0.0127498275,
-0.023290204,
-0.02013199,
-0.021912547,
0.0123014385,
0.02937269,
-0.031088265,
-0.016466903,
0.018026514,
-0.003359664,
0.012996766,
0.007453645,
-0.015934035,
-0.023329195,
0.0040972303,
-0.019768082,
-0.032777842,
-0.01840342,
0.0043831593,
0.025421673,
0.026929298,
0.016167976,
-0.006771315,
0.03748267,
0.014647355,
0.014504391,
-0.002118473,
-0.010332429,
0.00643015,
-0.024758838,
0.029008782,
0.019508146,
-0.009026254,
0.026175486,
-0.015011265,
-0.01623296,
0.021184728,
-0.008083988,
-0.0111772185,
0.011125231,
-0.007538124,
-0.05931724,
0.035195243,
-0.026526399,
-0.008603859,
-0.0277351,
-0.029190736,
-0.0011031005,
-0.0031598387,
0.014374423,
-0.0030249972,
0.031192238,
-0.035819087,
0.02387506,
-0.015895044,
0.0057998067,
-0.011313684,
-0.0073366743,
0.008038499,
0.01896228,
-0.007960519,
-0.0011063496,
0.0002910057,
-0.020287951,
-0.011138229,
0.01575208,
-0.00566659,
-0.021041764,
0.0076226033,
-0.015700093,
-0.02326421,
-0.0097345775,
-0.0051889587,
-0.014530384,
-0.045540668,
0.004207703,
0.014088494,
-0.015687097,
0.012788817,
-0.02149665,
-0.026929298,
0.024693856,
0.011443652,
0.042785354,
-0.025122749,
0.021171732,
0.022159485,
0.010020507,
-0.021899551,
0.0059817615,
0.0051077288,
-0.013672598,
0.031738102,
0.014751329,
-0.002451515,
-0.0152841965,
-0.022887304,
0.012398914,
0.0056113536,
-0.007668092,
0.026292458,
-0.002342667,
-0.0025944794,
-0.013399665,
0.010384416,
-0.001985256,
0.00044838843,
-0.013763575,
0.01884531,
0.0013272947,
-0.0048250495,
-0.018052507,
0.018624365,
0.012691342,
0.007830552,
-0.025616625,
-0.013919536,
-0.009910034,
-0.028670866,
0.0015384922,
0.026773337,
-0.01490729,
0.021366684,
0.024342943,
0.006563367,
-0.0057608164,
-0.0132631995,
0.009487639,
-0.016141983,
-0.011820558,
0.037976548,
0.002527871,
0.0010178093,
0.017493647,
-0.004223949,
0.013516637,
-0.030308457,
-0.002688706,
-0.021392677,
-0.008006007,
0.011554125,
0.019599123,
-0.012515886,
-0.021275707,
0.006563367,
-0.019053258,
-0.018585375,
-0.031322207,
-0.0053546675,
0.009182215,
-0.02153564,
0.010910785,
-0.009637102,
-0.0013110487,
0.014049504,
0.0035708614,
-0.009208209,
-0.0018422916,
0.015908042,
-0.013906539,
0.01816948,
0.0007773691,
0.0005024062,
0.0057283244,
-0.0029193985,
-0.019313194,
-0.027345195,
-0.005367664,
-0.009006759,
-0.020950787,
-0.0097345775,
-0.006127975,
-0.008967768,
0.0066445963,
-0.0037560654,
0.02507076,
-0.010891289,
0.021054761,
0.0035481171,
0.010306436,
0.0135816205,
-0.014855304,
-0.011827057,
0.018013518,
-0.016531887,
-0.024758838,
0.013412663,
-0.019755084,
0.0024677608,
-0.0051174765,
-0.014556378,
-0.021769583,
0.018624365,
-0.03709277,
0.0065113795,
-0.004600855,
0.00019220998,
-0.008311432,
0.02516174,
0.013828559,
-0.022133492,
-0.022341441,
0.01599902,
-0.0025977285,
0.00035010037,
-0.02869686,
0.002981133,
-0.012164973,
-0.009689089,
-0.015973026,
-0.009019756,
-0.029606633,
0.047074284,
-0.013919536,
-0.017636612,
-0.016427912,
0.0022890554,
-0.03665088,
-0.01965111,
-0.017090747,
-0.0104494,
0.011014759,
0.02495379,
-0.007297684,
0.018910294,
0.01362061,
-0.002367036,
-0.0025733595,
-0.01599902,
0.0016522139,
-0.035715114,
0.027865065,
0.008454396,
-0.010832804,
-0.010202461,
0.040731866,
0.007076739,
-0.024134994,
0.03121823,
-0.012938281,
0.008382914,
-0.014556378,
0.0031175993,
0.013211212,
0.009754073,
0.0217046,
-0.030074516,
0.018936288,
0.02981458,
-0.0014637607,
-0.011274694,
-0.01141116,
0.005936273,
-0.008902784,
0.010020507,
0.004886784,
-0.017155731,
0.009708584,
-0.017181724,
0.023862062,
0.017584624,
-0.018091498,
0.0021769584,
0.012730332,
-0.031270217,
-0.02069085,
0.0035091268,
-0.027501157,
0.007908532,
0.0038210491,
0.023407176,
-0.015479148,
0.0065113795,
-0.0070962342,
-0.037352704,
-0.000004102739,
-0.011287691,
0.02627946,
-0.009435652,
0.0049355216,
0.03150416,
-0.014075497,
-0.017987523,
-0.0148683,
-0.02583757,
-0.014686345,
0.0066933343,
-0.017064754,
0.0072716903,
-0.013256701,
0.010338928,
-0.00092683185,
0.001006437,
-0.02789106,
-0.0043344214,
-0.013289193,
0.034857325,
0.17997922,
-0.0055106287,
-0.0067453217,
0.02366711,
-0.001957638,
-0.001199764,
0.0019478903,
-0.001756188,
-0.003010376,
-0.002721198,
0.014686345,
-0.004766564,
-0.0052734376,
-0.0011307186,
0.011671096,
-0.02431695,
-0.017155731,
0.012483394,
-0.007089736,
-0.013763575,
0.011040753,
0.0088378005,
0.022354437,
-0.0016067252,
0.02700728,
0.005715328,
-0.018533388,
0.013672598,
0.028436923,
0.0012411912,
-0.017142734,
0.037326712,
0.018858308,
0.023121247,
0.012385918,
0.02708526,
-0.0075316257,
-0.018637363,
0.022562385,
-0.01076782,
0.0018033013,
-0.0040127514,
-0.017701594,
0.0062871855,
0.0026464665,
0.0021509647,
-0.026318451,
-0.009448648,
-0.01792254,
0.010715834,
-0.04517676,
0.008655846,
0.0021233466,
0.020521894,
0.0049647647,
-0.015479148,
0.01816948,
0.018442411,
-0.006075988,
-0.004532622,
-0.02258838,
-0.00005361166,
-0.036520913,
0.026851319,
-0.018780326,
0.030854322,
-0.017662605,
-0.02507076,
-0.005871289,
-0.021652611,
-0.0029486413,
0.009968519,
0.002592855,
-0.017870553,
-0.009520131,
-0.0018877803,
0.012093491,
0.012548378,
0.016726838,
0.02752715,
-0.0041654636,
-0.00267246,
-0.037300717,
-0.0062384475,
-0.011268196,
-0.016518889,
0.026253467,
0.012509387,
-0.038600396,
0.011125231,
0.0077655674,
-0.00783705,
-0.013185219,
-0.0024401427,
0.004054991,
-0.019196223,
0.0100854905,
-0.019053258,
-0.02149665,
-0.01362061,
-0.02620148,
0.077668674,
0.009669594,
-0.0062287,
-0.011489141,
0.016726838,
-0.0034603889,
0.0192872,
-0.00425969,
0.00002675506,
0.003223198,
-0.022289453,
0.008616855,
-0.011684093,
-0.01048839,
0.021431668,
0.014634359,
-0.009858047,
0.022042515,
-0.011658099,
-0.026903305,
0.007388661,
0.015973026,
-0.0022273208,
-0.018650359,
0.011034254,
-0.028644873,
0.007128726,
-0.008161969,
-0.04686634,
-0.016479898,
-0.008701335,
0.00021383741,
0.025928548,
0.022211473,
0.021470657,
0.007141723,
0.01265885,
-0.007785063,
0.039640136,
-0.013412663,
-0.0051402207,
0.0043214248,
0.013529633,
0.018793324,
-0.002053489,
0.015115239,
0.026019525,
-0.027657118,
-0.013256701,
-0.022549389,
-0.018559381,
0.0067063314,
-0.0088378005,
0.021665609,
-0.037118763,
-0.013016261,
-0.02885282,
0.013724585,
0.001816298,
-0.011001762,
0.0016067252,
0.02620148,
-0.025902554,
-0.0049810107,
-0.0056925835,
-0.1611599,
-0.011742578,
0.014764326,
-0.013477646,
0.016297944,
0.018988274,
-0.005244195,
0.012743329,
-0.003850292,
-0.008083988,
0.031374194,
0.009721581,
-0.05276687,
-0.0042531914,
0.009455147,
-0.007297684,
0.007850046,
0.017090747,
0.0049517676,
0.0075966096,
0.025291706,
-0.025122749,
-0.008090487,
-0.020872805,
0.011736079,
0.024407927,
0.009013257,
-0.000670958,
0.0069792634,
-0.015609115,
-0.035065275,
0.023771085,
0.014881297,
0.024706852,
0.03446742,
0.009396662,
0.018936288,
-0.0061312243,
-0.009422655,
0.011567121,
0.027293209,
0.0034928808,
-0.0076096063,
0.01980707,
-0.019924043,
0.012294941,
0.0103129335,
0.0052734376,
0.034623384,
-0.0066251014,
0.024940794,
-0.01659687,
-0.004545619,
0.019183226,
0.027397182,
0.027423175,
0.0150892455,
0.012912286,
-0.015440158,
0.0049842596,
-0.007512131,
-0.020807821,
0.01386755,
0.005377412,
0.0057413215,
-0.025200728,
0.006875289,
0.0036780848,
-0.006868791,
0.009143225,
-0.030074516,
-0.011079743,
0.016726838,
-0.022614373,
0.023355188,
0.01394553,
-0.010228455,
0.014296442,
0.0055853603,
0.025733596,
-0.0148683,
0.0021590877,
-0.040575903,
-0.02109375,
-0.019924043,
0.01663586,
0.034181494,
0.0067973086,
-0.009546124,
0.02644842,
0.028073015,
-0.021795576,
-0.0008447898,
-0.007733076,
0.03342768,
0.00908474,
0.0049485187,
-0.0012834306,
-0.0237061,
-0.00055236253,
0.025746593,
-0.011138229,
-0.011144727,
0.009624105,
0.013243704,
-0.0006307493,
-0.028904807,
-0.015076248,
0.044682883,
-0.021964535,
0.008402409,
-0.0005872914,
0.000077320605,
0.03620899,
0.007213205,
0.019781077,
0.008233451,
-0.0065926095,
-0.0009552623,
-0.010137477,
0.053078793,
-0.003954266,
0.011534629,
0.019586125,
-0.0029681365,
-0.021483654,
-0.12871997,
-0.033843577,
0.01249639,
0.012814811,
-0.002435269,
0.009468144,
-0.014218462,
0.027319202,
0.010228455,
0.022796327,
0.008103483,
0.0180785,
-0.0035936057,
-0.017571628,
0.012041504,
-0.0077135805,
-0.006329425,
-0.011268196,
-0.028021026,
0.020755835,
-0.010267445,
-0.013159226,
0.02516174,
-0.0032118259,
0.023784082,
-0.0021493402,
-0.014894294,
0.028540898,
0.012177969,
0.014283446,
0.007733076,
-0.0021395925,
0.022003524,
0.0068557938,
-0.011352675,
-0.042369455,
0.011430656,
-0.012294941,
0.041979555,
0.003973761,
0.0046365964,
-0.00699226,
0.036053028,
-0.008402409,
-0.0037625637,
-0.013971523,
-0.03467537,
-0.008155471,
0.013568624,
-0.02724122,
-0.041407697,
-0.019534139,
-0.031712107,
-0.0015717964,
0.026344445,
0.006634849,
-0.005663341,
0.027475163,
-0.021028766,
0.009994513,
0.0011680843,
-0.0011185341,
-0.008779315,
-0.010176468,
0.01185305,
-0.009695588,
-0.005549619,
-0.05011553,
0.011203212,
-0.015297193,
0.0061377226,
0.012665348,
-0.0036585897,
-0.015466152,
-0.020885803,
0.011378668,
0.0070117554,
-0.02387506,
0.0011526507,
-0.018065505,
-0.011502137,
-0.013516637,
-0.006738823,
-0.02768311,
0.012379419,
0.0065243766,
0.018494397,
0.014452403,
0.010403911,
-0.005614603,
-0.03298579,
0.027397182,
0.012132481,
-0.011138229,
0.005192208,
-0.0036455928,
-0.022003524,
-0.0034733857,
0.021483654,
0.0126848435,
-0.01197652,
-0.024784833,
-0.05365065,
0.014218462,
0.0026513403,
0.027631124,
-0.0037820588,
-0.031192238,
0.019118242,
-0.023758087,
0.010241452,
0.0021200974,
-0.02958064,
0.007141723,
0.0012712461,
0.0047210753,
-0.02278333,
0.0027943046,
0.012509387,
0.01961212,
0.0035383694,
-0.0043994053,
-0.019144235,
-0.0069207777,
-0.015596119,
0.0048282985,
-0.01707775,
0.017012766,
-0.020404922,
0.01322421,
-0.03680684,
-0.014439407,
-0.014933284,
-0.041927565,
-0.004360415,
-0.0019625116,
-0.021080755,
-0.0137765715,
-0.002419023,
0.031530153,
0.018624365,
0.013334682,
-0.020404922,
-0.0373787,
0.014517387,
-0.011268196,
0.017753582,
-0.00743415,
-0.03355765,
0.0039282725,
-0.008181464,
-0.021925544,
0.049933575,
0.001579107,
-0.0060889847,
-0.032153998,
-0.008038499,
0.00026765215,
0.00092358264,
-0.013490643,
-0.0042921817,
-0.023251215,
0.0026415926,
0.031842075,
0.017831562,
-0.0063716643,
0.030724354,
0.0030314957,
-0.01479032,
0.0015864178,
0.009910034,
-0.013802566,
-0.023420172,
-0.013490643,
0.005959017,
0.008694836,
0.0106638465,
-0.0131657235,
-0.007161218,
-0.009240701,
0.0049095284,
0.018949285,
-0.0034993791,
-0.012164973,
-0.031556148,
0.014933284,
0.011229206,
0.019482153,
0.0005361166,
0.015297193,
-0.0066803377,
0.015063251,
0.011326682,
0.015245207,
0.016064003,
-0.0029876316,
0.033947553,
0.0073366743,
0.012509387,
0.010319432,
0.0009869419,
0.034389444,
0.004288933,
0.008148972,
0.000599882,
-0.0102154575,
-0.014920287,
0.030776342,
-0.039848085,
-0.033219732,
0.006927276,
0.01571309,
-0.0043311724,
0.0065568686,
-0.010566371,
-0.005656842,
-0.012353426,
0.027345195,
-0.0060662404,
-0.0064918846,
0.0019755084,
0.022185478,
0.017987523,
0.009955523,
-0.0121389795,
0.0020242464,
0.019118242,
-0.0008094548,
0.04476086,
-0.0123014385,
0.03545518,
-0.010462397,
0.0012062624,
-0.016765827,
-0.026552392,
-0.015388171,
-0.013074746,
-0.006365166,
0.012035005,
0.04842595,
-0.0076420982,
0.081151806,
-0.0065926095,
-0.020157984,
-0.0035253728,
-0.009741076,
0.023927046,
0.002756939,
0.03995206,
-0.009091238,
-0.026344445,
0.034181494,
-0.0049940073,
0.024160987,
-0.045748618,
-0.01350364,
0.00085534964,
-0.005663341,
0.008954772,
-0.019833066,
-0.0038892822,
0.030932304,
-0.006972765,
0.008499885,
0.013724585,
-0.035429183,
0.016908793,
0.058641408,
-0.00235079,
0.01772759,
-0.03545518,
-0.01744166,
0.027163241,
-0.044344965,
-0.009663096,
0.0017626864,
-0.02796904,
-0.018572379,
-0.014257452,
0.017831562,
0.015037258,
-0.015635109,
0.0056763375,
-0.022536391,
-0.03199804,
-0.005175962,
-0.011086241,
-0.034129508,
0.01394553,
-0.036234982
] |
Expression levels of many microRNAs (miRNAs) change during aging, notably declining globally in a number of organisms and tissues across taxa. However, little is known about the mechanisms or the biological relevance for this change. We investigated the network of genes that controls miRNA transcription and processing during C. elegans aging. We found that miRNA biogenesis genes are highly networked with transcription factors and aging-associated miRNAs. In particular, miR-71, known to influence life span and itself up-regulated during aging, represses alg-1/Argonaute expression post-transcriptionally during aging. Increased AL | [
-0.016097216,
-0.02669848,
0.015006108,
-0.023694564,
-0.009348509,
0.01590863,
-0.03149397,
0.017565498,
-0.02074453,
-0.02330392,
0.003310369,
0.0047517098,
0.010897613,
-0.009833446,
-0.001438815,
0.005149089,
0.027776117,
0.022832453,
0.024475852,
0.011065994,
-0.018373726,
0.026105778,
-0.0060347724,
-0.032194432,
-0.0035898814,
0.009934475,
0.0032076566,
-0.040546127,
0.010190413,
-0.023250038,
0.019128073,
0.004654049,
-0.012648775,
0.00077749894,
-0.008028403,
-0.0017663159,
0.0070922044,
-0.037905913,
0.006085287,
0.0008671618,
0.037690386,
0.011618284,
-0.008722132,
0.0013798816,
0.013093301,
0.01794267,
-0.011032318,
-0.016595624,
-0.0072067035,
0.020367356,
-0.0060448754,
-0.0027244033,
-0.027250769,
-0.011396021,
-0.021795226,
0.002340495,
0.008452723,
0.033352893,
-0.002843954,
0.019464836,
-0.009368715,
0.002727771,
-0.0229941,
0.003778468,
-0.011705842,
0.012379366,
0.0047281366,
0.0024853025,
0.020838823,
-0.012621834,
0.023910092,
0.018117787,
0.00029256186,
0.018548843,
-0.004808959,
-0.018117787,
-0.016730329,
0.021337232,
-0.0008023351,
0.009732418,
0.013329034,
0.0020811881,
0.014170938,
0.016272333,
0.004068083,
-0.0042600376,
-0.008216989,
0.01965342,
0.01093129,
-0.01010959,
0.01562575,
0.0014404989,
0.031682555,
0.03701686,
-0.0077455225,
-0.008190048,
0.0034332871,
0.018845193,
-0.024004385,
-0.0150734605,
-0.03205973,
0.00453955,
6.1991807e-7,
-0.007449172,
-0.022185871,
-0.006556753,
0.01350415,
-0.006277241,
0.024031326,
-0.023627212,
-0.01477711,
0.026321307,
0.0040748185,
-0.03812144,
0.008176577,
-0.009853652,
0.03755568,
0.0066880905,
0.0021165481,
-0.012527541,
0.02186258,
0.022953687,
0.01760591,
-0.038013678,
0.00018700806,
0.021552758,
-0.0025610738,
0.014292173,
-0.030739622,
-0.0051053097,
0.0010027084,
0.006614003,
0.0042398316,
0.021337232,
-0.03351454,
0.0018117788,
-0.009328303,
-0.014938756,
0.0011129979,
-0.036531925,
-0.009065629,
0.03521182,
-0.041650705,
0.0061054924,
-0.008641309,
0.006213256,
0.015531456,
0.0043678014,
0.02527061,
0.0012923236,
-0.0063951076,
-0.017767556,
0.025971074,
-0.023074921,
-0.0010170208,
0.021418054,
0.014332584,
0.015248576,
-0.007860022,
-0.013834177,
0.013382916,
0.0035157937,
0.011665431,
0.01764632,
-0.004458727,
0.030901268,
-0.0057047457,
-0.0019447997,
0.004458727,
-0.012891243,
0.0007572932,
0.016083745,
-0.02100047,
0.022199342,
0.00476518,
0.017134443,
0.0036336603,
0.00688678,
-0.027883882,
-0.024664437,
0.00023047139,
0.0036504983,
0.019626481,
-0.0014472341,
-0.009213804,
-0.0021215996,
0.009678535,
0.022051167,
0.0093821855,
-0.022832453,
-0.020933116,
0.010695556,
0.017848378,
0.0007926532,
-0.6310648,
-0.03777121,
0.012709392,
-0.013739884,
0.006310917,
0.010735968,
-0.004994178,
-0.0011567769,
0.000264779,
0.030551035,
-0.0012300226,
0.015531456,
0.024017856,
-0.01845455,
-0.02388315,
-0.040734712,
-0.0096044475,
-0.030577976,
0.024839554,
0.020353885,
-0.026496422,
-0.01619151,
0.016636034,
0.019370541,
-0.0029180413,
0.012285072,
0.018333316,
-0.025243668,
0.0036067194,
0.019707303,
-0.009698741,
0.03160173,
-0.010022033,
0.004654049,
0.04746995,
-0.007415496,
-0.0031386204,
0.018548843,
-0.004313919,
0.014884873,
-0.026671538,
-0.013915,
0.025688194,
-0.0058596563,
-0.0330296,
0.009995092,
-0.00009792403,
-0.0022748264,
0.013254946,
0.006088654,
0.0063749016,
0.03860638,
-0.023182686,
-0.017821437,
-0.003670704,
0.010884143,
0.01959954,
-0.028853755,
0.01931666,
-0.01590863,
-0.007583877,
0.0141170565,
-0.029096223,
0.0051524565,
-0.020071005,
0.0033474127,
-0.022576515,
0.026509892,
0.02074453,
0.006287344,
0.013834177,
0.012163838,
-0.007893697,
0.0042263614,
0.011827076,
0.022037696,
-0.013820706,
0.01307983,
-0.01336271,
0.0043678014,
0.00427014,
-0.00865478,
-0.026496422,
0.021835638,
0.018683547,
0.0027698663,
-0.017161384,
0.020084476,
-0.01563922,
0.014911815,
0.0028001748,
-0.007563671,
-0.018562313,
-0.05032569,
-0.010715762,
-0.0063782693,
0.0009058894,
0.012190779,
0.022347515,
-0.028153291,
-0.005128883,
0.0030914738,
0.017255677,
-0.0014463922,
0.0073750843,
0.015383282,
-0.031009031,
0.0069575,
0.03610087,
-0.026873596,
0.006075184,
0.03919908,
-0.01845455,
-0.02244181,
-0.03265243,
-0.026752362,
0.0066241054,
0.0029853939,
0.006620738,
-0.029904453,
-0.00053418847,
-0.005199603,
0.0019178587,
-0.010951496,
0.0037111156,
-0.00009624022,
0.00047946468,
-0.00893766,
0.00014670187,
0.0028759462,
0.002603169,
0.0042768754,
0.0016476073,
-0.027466297,
0.019343602,
0.0072538503,
0.019437894,
0.007078734,
0.0030998928,
-0.017134443,
-0.026590716,
-0.020111417,
-0.0023640683,
-0.008459457,
-0.0019346968,
-0.028584346,
-0.009186863,
0.015464104,
0.008863572,
0.011268051,
-0.001155935,
-0.0072269095,
-0.017444264,
0.028153291,
-0.0024297368,
-0.007812875,
-0.019235836,
-0.024408499,
0.0026890433,
-0.01732303,
-0.015383282,
0.029635042,
-0.039037433,
0.00069499225,
-0.016972797,
0.0010271237,
0.003406346,
0.025203256,
-0.012008928,
-0.017255677,
0.014143998,
-0.005475748,
-0.0077926693,
-0.0056710695,
-0.0030931577,
-0.0008772646,
-0.008553751,
0.021040881,
0.00056533894,
-0.014251761,
0.007045058,
-0.009173392,
0.0013100036,
-0.02327698,
0.03475382,
0.029661983,
0.0340803,
0.00034202376,
-0.0013167388,
0.03232914,
-0.012123426,
0.032517724,
-0.03577758,
0.014265232,
-0.00091935985,
-0.032571606,
0.0056003495,
-0.016043335,
0.014628935,
0.017713673,
0.0022259958,
-0.023101863,
0.0011567769,
-0.021364171,
-0.0052299113,
-0.010749438,
-0.0042499346,
-0.01958607,
0.006556753,
0.027075652,
0.003381089,
0.01761938,
0.00001696964,
-0.012695922,
0.03604699,
0.002497089,
-0.00922054,
-0.009806505,
-0.0030072832,
-0.011294993,
0.005923641,
-0.009395655,
0.0026149557,
-0.0077118464,
-0.0053915572,
0.022859395,
0.009718947,
0.010439618,
0.01093129,
-0.01067535,
0.0020340416,
-0.0008419046,
0.013625384,
0.005209706,
0.006614003,
0.018265963,
0.0047719153,
-0.009112775,
0.025607372,
0.0006339542,
-0.020097947,
-0.011456639,
0.019424424,
-0.008297812,
0.0009816608,
-0.017107502,
0.03232914,
0.009011747,
-0.0028001748,
-0.0043475954,
-0.016326215,
0.0151542835,
-0.0097458875,
-0.025337962,
-0.011523991,
-0.020367356,
0.018144729,
-0.008695191,
0.026967889,
0.021849109,
0.04100412,
-0.0071595567,
-0.010601263,
-0.010035503,
0.0071258806,
0.00852681,
0.022509161,
0.011146817,
-0.017390382,
0.005586879,
-0.023438625,
-0.020017125,
0.014521171,
-0.036262516,
0.02555349,
0.0013849331,
0.0151946945,
0.021673992,
0.011012113,
0.026887067,
0.0031453557,
-0.022131989,
0.03410724,
0.009806505,
-0.0107022915,
-0.014857933,
-0.005650864,
0.007880228,
-0.00951689,
-0.0009858704,
0.005782201,
0.016420508,
0.017794495,
0.0035696756,
-0.007758993,
0.007051793,
0.015100401,
-0.049625225,
0.009483214,
-0.01593557,
0.004741607,
-0.0056946427,
0.008600898,
-0.013147183,
0.032248314,
0.0063041816,
-0.0038020413,
-0.011301728,
-0.0201653,
-0.0059270086,
-0.016716858,
-0.0008482189,
0.011294993,
-0.015975982,
0.0027244033,
0.014952227,
0.0062907115,
-0.015814336,
0.0017595807,
0.012554482,
-0.009173392,
-0.052777316,
-0.0055195265,
0.0044149477,
0.041920114,
0.0030140185,
-0.012177308,
0.015746985,
0.0013150551,
0.0029550851,
-0.014992638,
-0.032787133,
0.015989453,
-0.012547746,
-0.003179032,
-0.0034922203,
0.0107831145,
-0.018912546,
0.0118405465,
0.022657337,
0.014332584,
-0.049086407,
-0.02955422,
-0.0019229102,
0.012776745,
-0.0062098885,
0.016811151,
0.051780503,
0.017834907,
0.001756213,
-0.006065081,
0.014130527,
0.01562575,
-0.017107502,
0.010621469,
0.0025661252,
0.008688455,
0.025890252,
-0.0039468487,
0.02215893,
0.02131029,
0.01988242,
0.0070652636,
-0.0084863985,
0.0032716414,
0.012749803,
0.007866757,
-0.017444264,
-0.005058163,
-0.019087661,
-0.017174855,
0.014857933,
-0.028907638,
-0.023384742,
0.017511616,
-0.019734245,
-0.0007438227,
-0.01988242,
0.026509892,
0.014170938,
0.00854028,
0.008311283,
-0.00012102379,
-0.037905913,
0.0038256147,
-0.016555212,
0.028045528,
-0.016339686,
0.011375816,
-0.011645225,
0.011119876,
-0.0072269095,
-0.01363212,
-0.005196235,
0.011200699,
-0.011416227,
-0.021054352,
-0.00062890275,
-0.005209706,
0.03607393,
0.02415256,
-0.032409962,
0.0049571344,
0.01590863,
0.0050716335,
-0.020071005,
0.0052467496,
-0.03577758,
0.028153291,
-0.01221772,
-0.0041691116,
-0.00397379,
-0.02955422,
-0.016811151,
0.002631794,
-0.0021434892,
0.038821906,
-0.00965833,
0.0012805369,
0.0050110165,
0.026334777,
0.034241945,
-0.0076983757,
-0.008567221,
-0.0015440531,
-0.021458466,
-0.0167438,
-0.033460658,
-0.022953687,
-0.025593901,
0.010776379,
0.00427014,
-0.017201796,
-0.012204249,
0.0032901634,
-0.014292173,
0.009934475,
0.03276019,
0.009550566,
0.021700934,
0.003670704,
0.007752258,
-0.0077926693,
0.007011382,
-0.012460188,
-0.009227275,
0.027169947,
0.018818252,
-0.011382551,
0.021498876,
-0.024556674,
-0.004236464,
-0.035535112,
0.005863024,
0.0012291807,
0.045233853,
0.0032581708,
-0.045961257,
-0.013652326,
-0.007758993,
0.014655876,
0.0056104525,
-0.010554116,
-0.0118405465,
-0.025405314,
0.0017174855,
0.00086547795,
-0.0065634884,
0.03130538,
-0.034403592,
0.0022276796,
0.029608103,
0.020407768,
0.014615464,
0.019842008,
0.0017747349,
-0.012662246,
-0.011665431,
-0.03011998,
-0.04006119,
0.014507701,
0.0030224377,
0.05032569,
0.004660784,
0.04043836,
0.0071595567,
-0.0033389938,
0.035723697,
0.02420644,
-0.0007471904,
0.0049200905,
0.044102333,
-0.001421135,
0.006826163,
0.022414869,
0.013093301,
-0.00088399986,
-0.031143736,
-0.0027311386,
0.009052158,
-0.013888058,
-0.042243406,
-0.007045058,
-0.048763115,
-0.038202263,
0.013254946,
-0.02754712,
0.019532187,
-0.033164307,
-0.0072403797,
0.028180232,
0.008971335,
0.020986998,
-0.004620373,
0.024462381,
-0.017700203,
0.03321819,
-0.00937545,
-0.01163849,
-0.017120972,
-0.003566308,
-0.004175847,
-0.005280426,
0.0118001355,
-0.025418784,
0.023667622,
-0.007799404,
-0.02043471,
0.018104317,
0.0015844645,
-0.024462381,
-0.01931666,
-0.022293635,
-0.026860125,
-0.018090846,
-0.024543203,
-0.021162115,
-0.032248314,
0.0052029705,
0.0070315874,
-0.010399206,
0.027964704,
-0.0042768754,
-0.028099408,
0.02558043,
0.0005602875,
0.020192241,
-0.021040881,
0.016636034,
0.026267424,
0.0007282475,
-0.009894063,
-0.02050206,
0.013025949,
0.004350963,
0.033541482,
0.028314937,
-0.028449642,
-0.011254581,
0.025661252,
0.008991541,
-0.007866757,
-0.023317391,
0.024502791,
0.009846916,
0.006415313,
-0.004748342,
-0.012776745,
-0.023371272,
-0.0073818197,
-0.017269148,
-0.00053966086,
-0.0012182359,
-0.0060920217,
0.0095438305,
0.014332584,
0.0094428025,
0.004421683,
-0.007954315,
-0.010971701,
-0.008223725,
-0.005559938,
0.020879235,
-0.0055026887,
-0.02044818,
0.022131989,
-0.025540018,
0.009166658,
-0.0022546207,
-0.0073212027,
0.0042869784,
-0.013524356,
-0.007105675,
0.04803571,
-0.012635305,
-0.00434086,
0.010331853,
-0.002162011,
0.010015298,
0.0036606013,
-0.00028708947,
-0.012648775,
-0.0053646164,
-0.019545658,
0.026779301,
0.023600271,
-0.0029365632,
0.016016394,
-0.02925787,
0.01122764,
-0.020246122,
-0.01790226,
0.015733514,
-0.04014201,
-0.000018390354,
0.013888058,
0.0213507,
0.021849109,
0.016110687,
-0.009880593,
-0.020569414,
0.02869211,
-0.022024225,
0.039333783,
-0.002303451,
-0.038229205,
-0.0071191457,
0.0058024065,
-0.020825353,
-0.018562313,
0.027776117,
-0.023196157,
-0.03701686,
0.015288988,
-0.015369811,
0.038498614,
0.032598548,
-0.023708034,
0.0053208373,
0.0072067035,
0.0004457885,
-0.0025038244,
0.016811151,
0.007758993,
-0.023640681,
0.009159923,
0.007920639,
0.015773926,
0.008715397,
-0.0076040826,
-0.00037906755,
0.010917819,
-0.00839884,
0.0016114054,
-0.017147914,
0.023425154,
-0.008459457,
-0.008318017,
-0.008600898,
-0.015181224,
-0.025647782,
0.03262549,
-0.006805957,
-0.0055565704,
-0.01565269,
0.009867122,
0.0363164,
0.00476518,
0.010035503,
0.013672531,
-0.003576411,
-0.024610557,
-0.03720545,
-0.007826345,
-0.013746618,
0.03957625,
0.025418784,
0.0050446927,
-0.01064841,
-0.0014270283,
-0.04345575,
-0.03957625,
0.02271122,
0.021997284,
0.007051793,
0.0055902465,
0.018831722,
-0.003599984,
-0.00060238276,
-0.003707748,
0.00277155,
-0.007913903,
-0.0031722966,
0.00808902,
-0.0026991463,
-0.012291808,
-0.035427347,
-0.015504516,
0.02928481,
-0.0029904451,
-0.04431786,
0.009557301,
-0.016838092,
0.015019579,
-0.03232914,
-0.004724769,
-0.0022815615,
-0.0023640683,
0.014292173,
-0.03445747,
-0.004529447,
0.002790072,
-0.010863937,
-0.029311752,
0.016824622,
-0.01765979,
0.016649505,
0.018589254,
-0.0013790397,
-0.026482953,
0.013450269,
-0.007193233,
0.03262549,
0.032005847,
0.009294627,
0.030335508,
0.010513705,
-0.00612233,
-0.034511354,
-0.006873309,
-0.00089410273,
-0.010446353,
0.011247845,
0.0062570353,
-0.011220905,
-0.012446718,
-0.009914269,
-0.022967158,
-0.006802589,
-0.0045799613,
-0.017444264,
-0.023748446,
-0.009974886,
0.0037010128,
0.009328303,
0.015544927,
-0.0037010128,
0.0074559073,
-0.029069282,
-0.00013133712,
-0.022199342,
-0.0064388867,
0.0049672374,
0.010311648,
-0.008742338,
0.0021215996,
-0.0046271076,
0.019518716,
0.00047735992,
0.022589985,
0.19095744,
-0.0058495533,
-0.0046843574,
-0.0010102856,
-0.0011012113,
-0.016541742,
0.035346523,
-0.0058832294,
-0.0071258806,
0.009409126,
-0.009126246,
0.011005377,
-0.026685009,
-0.00019921568,
0.009577507,
-0.03887579,
-0.010156738,
0.0151946945,
-0.016945856,
-0.0053713517,
-0.0036269252,
-0.009887327,
0.0030695843,
0.00042852946,
0.037151568,
0.00029024662,
-0.03011998,
0.0013259997,
-0.006991176,
-0.0010018665,
-0.0123861,
-0.0070046466,
-0.0084661925,
0.008991541,
0.0074087605,
0.009947945,
-0.011254581,
-0.007166292,
0.0021081292,
-0.017969612,
0.0036841747,
0.026577245,
0.0017444264,
-0.012096486,
0.019208895,
0.014480759,
-0.0067823837,
-0.012810421,
-0.024960788,
-0.009180128,
-0.04326716,
0.0072403797,
-0.000467678,
0.035104055,
0.0038155117,
0.015181224,
-0.0023943768,
0.013457003,
0.004236464,
0.012716128,
0.0023556491,
-0.007469378,
-0.023761917,
-0.011119876,
-0.011470108,
0.03871414,
-0.0115980785,
0.0106820855,
0.020515531,
-0.016245391,
-0.007139351,
-0.015720043,
-0.016043335,
-0.00031823994,
-0.02614619,
-0.0056542316,
0.053531665,
0.026617657,
0.009328303,
0.014601993,
-0.0037447917,
-0.00025888567,
-0.045126088,
0.011557667,
-0.006075184,
-0.033999477,
0.023115333,
0.0012392836,
-0.019343602,
-0.026914006,
0.021094762,
-0.025311021,
-0.0076983757,
-0.007853286,
0.01704015,
0.007132616,
-0.004775283,
0.0105810575,
-0.0084863985,
-0.020030595,
-0.047065835,
0.045314673,
-0.003583146,
0.0201653,
0.0049638697,
0.00909257,
-0.010042238,
0.018548843,
-0.014965696,
-0.01207628,
-0.0006815218,
-0.013793766,
0.016056806,
-0.0119011635,
-0.008412311,
-0.0021047615,
0.010614733,
-0.021687463,
0.04458727,
-0.0235868,
-0.022792041,
-0.02669848,
-0.002145173,
0.01650133,
-0.012224455,
-0.0072269095,
-0.01849496,
-0.011604813,
-0.026024956,
-0.041973997,
0.015423693,
-0.018010024,
-0.009139717,
0.006576959,
0.001721695,
-0.024745261,
0.013968881,
-0.013201064,
-0.00070677896,
0.0038794966,
-0.005516159,
-0.009415861,
-0.0021721139,
-0.011907899,
-0.007482848,
0.012655511,
0.021660522,
0.031925023,
-0.011012113,
-0.008109225,
-0.022643866,
-0.01562575,
0.0021199158,
0.012837362,
0.026469482,
0.0024128987,
-0.026173132,
-0.019047251,
-0.012985537,
0.007846551,
-0.03469994,
0.013403121,
0.023667622,
-0.012884509,
0.00996815,
-0.020906176,
-0.17026679,
0.0049537667,
0.011025583,
-0.015746985,
0.031170677,
0.00653318,
0.015491045,
-0.025203256,
-0.0043442277,
0.00344339,
0.011039053,
0.002515611,
-0.02955422,
-0.048682295,
0.025620842,
0.020569414,
0.004862841,
0.023034511,
0.023209626,
0.0074424366,
0.029581161,
-0.018292904,
0.017525086,
-0.013659061,
-0.009260951,
0.013443533,
0.016326215,
-0.012466923,
-0.0034619118,
-0.018912546,
-0.021404583,
0.0014977483,
0.020825353,
0.0006667885,
0.0173365,
0.010527176,
-0.014642405,
-0.009590978,
-0.029958334,
0.007247115,
0.030066097,
0.0352657,
-0.009193598,
0.02214546,
-0.013618649,
0.026334777,
0.0038525555,
-0.01534287,
0.02672542,
-0.00996815,
0.0003319209,
-0.002268091,
0.017713673,
-0.009779564,
0.022589985,
0.011550931,
0.01590863,
0.016407037,
-0.0066779875,
-0.0026368452,
-0.0022041062,
0.0117799295,
0.03890273,
0.015544927,
0.026738891,
0.008136166,
-0.013861118,
0.024920376,
-0.012022398,
0.0000061958917,
-0.0250012,
-0.012338954,
0.00029235138,
-0.007758993,
0.036020048,
0.013652326,
-0.01790226,
0.0173365,
0.0004474723,
0.006408578,
-0.019707303,
0.029715866,
-0.03491547,
-0.010978436,
0.0037717328,
-0.009058894,
0.019114602,
0.022387927,
0.007280791,
-0.010493499,
0.020124888,
-0.012271602,
0.00865478,
-0.0037986736,
0.011928105,
0.009806505,
0.002648632,
-0.0041084946,
-0.0016130892,
-0.023088392,
0.024314206,
-0.020273063,
0.015854748,
0.004445256,
0.030901268,
-0.011463373,
-0.023074921,
0.0024432072,
0.03548123,
-0.006081919,
0.0003626504,
0.021512346,
0.008762543,
0.027452826,
-0.017511616,
0.021768287,
-0.008499869,
-0.011995457,
-0.028934577,
-0.009065629,
0.060455486,
0.0358584,
0.00681606,
0.007981256,
-0.0039939955,
-0.03375701,
-0.12554482,
-0.023250038,
0.00418595,
0.017511616,
-0.013760089,
0.012749803,
-0.009065629,
0.03642416,
-0.014952227,
0.037528742,
-0.024071736,
0.000054618562,
-0.012109956,
-0.015167754,
0.0027143005,
-0.02159317,
0.00639174,
-0.010574322,
0.0012645407,
0.04318634,
0.0066510467,
0.0036841747,
0.011557667,
0.009510155,
0.002128335,
-0.0007703427,
-0.017444264,
0.010971701,
0.008048608,
-0.0034753822,
-0.0010229141,
-0.0003742266,
0.01122764,
-0.014238291,
-0.021660522,
-0.026186602,
0.017821437,
-0.0072673205,
0.008459457,
-0.0014287122,
0.01562575,
0.009786299,
0.009496684,
-0.0053444104,
0.015598808,
0.00085579604,
0.006294079,
0.009819975,
-0.0073750843,
-0.025391843,
-0.01760591,
-0.03494241,
-0.028287996,
-0.020124888,
0.011577873,
-0.017969612,
0.013201064,
0.012466923,
-0.013591709,
-0.018926015,
0.0052366466,
-0.00082843413,
-0.027587531,
0.012204249,
0.010163473,
-0.029230928,
-0.0150734605,
-0.023465566,
-0.0034551765,
-0.02672542,
0.000626798,
0.025095493,
-0.0011483579,
0.00305443,
-0.03688216,
0.011335404,
0.0052299113,
-0.040168952,
0.012844097,
-0.018952956,
-0.01761938,
-0.020771472,
0.014184409,
-0.027196888,
0.022845924,
0.012305278,
0.005270323,
-0.0053814542,
0.012615099,
-0.004081554,
-0.0034282357,
0.03356842,
-0.007361614,
-0.00823046,
-0.018050436,
-0.0014615464,
0.0034097137,
-0.016097216,
-0.0012864303,
0.0051221475,
-0.016555212,
-0.010304913,
-0.056953166,
0.007139351,
-0.009894063,
-0.01565269,
0.0106416745,
-0.033406775,
0.012621834,
-0.017444264,
-0.022563044,
0.014022764,
-0.02074453,
-0.0031470396,
-0.01817167,
-0.0050952067,
-0.011059259,
-0.0003609666,
0.043321043,
-0.0066443114,
0.03351454,
0.023990914,
-0.0020256226,
0.030146921,
-0.007388555,
0.0049638697,
-0.025930662,
-0.012830626,
-0.02102741,
0.0031874508,
-0.010028768,
-0.003451809,
0.0075771417,
-0.039118256,
-0.003936746,
0.0001708014,
-0.01421135,
-0.032221373,
0.00781961,
0.043374926,
0.01846802,
0.01873743,
-0.014292173,
-0.029715866,
0.019747715,
-0.00038285612,
0.025351431,
0.0065264446,
-0.024853025,
-0.006452357,
0.0035797784,
-0.0037548947,
0.046176784,
0.002763131,
-0.015302459,
-0.028826814,
0.0020003654,
0.00045925897,
0.02100047,
-0.021539288,
-0.0074087605,
0.0022276796,
0.0074626426,
0.030658798,
-0.0187509,
-0.0030173862,
0.004246567,
0.0021502245,
-0.031467028,
0.009806505,
0.0026115882,
-0.040734712,
-0.011874223,
-0.0017797864,
0.014292173,
-0.01907419,
0.02048859,
0.0072605857,
-0.018400667,
0.016029865,
-0.0033053176,
0.023236567,
0.03130538,
0.01706709,
-0.016986268,
0.0014169255,
0.018602725,
0.025041612,
0.003680807,
0.0063951076,
0.012763274,
-0.001739375,
-0.0058495533,
0.010379001,
-0.00455302,
0.013342504,
-0.0057316865,
0.018993368,
-0.013093301,
0.015693102,
-0.027883882,
0.006614003,
0.01534287,
0.01094476,
-0.014157468,
-0.022589985,
0.008129431,
0.026200071,
-0.029661983,
-0.017794495,
0.016326215,
0.009590978,
0.003940114,
0.0072403797,
0.0033524642,
0.0040748185,
-0.0118607525,
0.028261054,
-0.01094476,
-0.02271122,
-0.010594528,
0.043644335,
0.021822168,
0.0057249516,
-0.0017578969,
0.0003653866,
0.011732783,
0.0159221,
0.023546388,
-0.03273325,
0.012830626,
-0.016097216,
0.029985275,
-0.014871404,
-0.021512346,
-0.011180493,
0.0034720146,
-0.016959326,
0.0026856759,
0.00039653707,
-0.037070744,
0.08405576,
0.016986268,
-0.007388555,
0.026105778,
-0.02050206,
0.025122434,
0.0067924866,
0.020569414,
-0.016838092,
-0.018036965,
0.0016535007,
-0.023937032,
0.016380096,
-0.038579438,
-0.010776379,
0.028584346,
-0.010897613,
0.047281362,
-0.0057990393,
-0.030928208,
0.013510886,
-0.016838092,
0.024341147,
0.014022764,
-0.039818723,
-0.005347778,
0.045637965,
0.0033659346,
0.008102491,
-0.03445747,
0.010527176,
0.019505246,
-0.03276019,
0.00936198,
0.013652326,
-0.02898846,
-0.009759358,
-0.021283349,
0.014453819,
0.003062849,
0.0011037369,
-0.015127342,
-0.008998277,
-0.0089646,
0.021795226,
-0.021458466,
-0.010062444,
-0.0014665979,
-0.022239752
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.