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Holidays and observances Christian feast day: Æbbe of Coldingham Aredius Genesius of Arles Genesius of Rome Ginés de la Jara (or Genesius of Cartagena) Gregory of Utrecht Joseph Calasanz Louis IX of France Blessed Ludovicus Baba Blessed Ludovicus Sasada Blessed Luis Sotelo Menas of Constantinople Blessed Miguel de Carvalho Patricia of Naples Blessed Pedro Vásquez Thomas de Cantilupe (or of Hereford) August 25 (Eastern Orthodox liturgics) Day of Songun (North Korea) Earliest day on which Father's Day can fall, while August 31 is the latest; celebrated on the last Monday in August. (South Sudan) Earliest day on which La Tomatina can fall, while August 31 is the latest; celebrated on the last Wednesday in August. (Buñol) Independence Day, celebrates the independence of Uruguay from Brazil in 1825. Liberation Day (France) Soldier's Day (Brazil) References External links Days of the year August
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1520_0
Aachen (; Aachen dialect: Oche ; French and traditional English: Aix-la-Chapelle; or Aquisgranum; ) is, with around 249,000 inhabitants, the 13th-largest city in North Rhine-Westphalia, and the 28th-largest city of Germany. It is the westernmost city in Germany, and borders Belgium and the Netherlands to the west, the Tri-border area. It is located between Maastricht (NL) and Liège (BE) in the west, and Bonn and Cologne, in the east. The Wurm River flows through the city, and together with Mönchengladbach, Aachen is the only larger German city in the drainage basin of the Meuse. Aachen is the seat of the City Region Aachen (). Aachen developed from a Roman settlement and thermae (bath complex), subsequently becoming the preferred medieval Imperial residence of Emperor Charlemagne of the Frankish Empire, and, from 936 to 1531, the place where 31 Holy Roman Emperors were crowned Kings of the Germans. One of Germany's leading institutes of higher education in technology, the RWTH Aachen University (Rheinisch-Westfälisch Technische Hochschule Aachen), is located in the city. Its university hospital Uniklinik RWTH Aachen is Europe's largest single-building hospital. Aachen's industries include science, engineering and information technology. In 2009, Aachen was ranked eighth among cities in Germany for innovation. The regional dialect spoken in the city is a Central Franconian, Ripuarian variant with strong Limburgish influences from the dialects in the neighbouring Netherlands. As a Rhenish city, Aachen is one of the main centres of carnival celebrations in Germany, along with Cologne, Mainz and Düsseldorf. The culinary speciality the city is best known for are Aachener Printen, a type of gingerbread. History
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1520_1
History Early history Flint quarries on the Lousberg, Schneeberg, and Königshügel, first used during Neolithic times (3000–2500 BC), attest to the long occupation of the site of Aachen, as do recent finds under the modern city's Elisengarten pointing to a former settlement from the same period. Bronze Age (around 1600 BC) settlement is evidenced by the remains of barrows (burial mounds) found, for example, on the Klausberg. During the Iron Age, the area was settled by Celtic peoples who were perhaps drawn by the marshy Aachen basin's hot sulphur springs where they worshipped Grannus, god of light and healing. Later, the 25-hectare Roman spa resort town of Aquae Granni was, according to legend, founded by Grenus, under Hadrian, around 124 AD. Instead, the fictitious founder refers to the Celtic god, and it seems it was the Roman 6th Legion at the start of the 1st century AD that first channelled the hot springs into a spa at Büchel, adding at the end of the same century the Münstertherme spa, two water pipelines, and a probable sanctuary dedicated to Grannus. A kind of forum, surrounded by colonnades, connected the two spa complexes. There was also an extensive residential area, part of it inhabited by a flourishing Jewish community. The Romans built bathhouses near Burtscheid. A temple precinct called Vernenum was built near the modern Kornelimünster/Walheim. Today, remains have been found of three bathhouses, including two fountains in the Elisenbrunnen and the Burtscheid bathhouse. Roman civil administration in Aachen eventually broke down as the baths and other public buildings (along with most of the villae rusticae of the surrounding countryside) were destroyed around AD 375 at the start of the migration period. The last Roman coin finds are from the time of Emperor Gratian (AD 375–383). Rome withdrew its troops from the area, but the town remained populated. By 470, the town came to be ruled by the Ripuarian Franks and subordinated to their capital, Cologne.
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1520_2
Etymology The name Aachen is a modern descendant, like southern German , , meaning "river" or "stream", from Old High German , meaning "water" or "stream", which directly translates (and etymologically corresponds) to Latin , referring to the springs. The location has been inhabited by humans since the Neolithic era, about 5,000 years ago, attracted to its warm mineral springs. Latin figures in Aachen's Roman name , which meant "waters of Grannus", referring to the Celtic god of healing who was worshipped at the springs. This word became in Walloon and in French, and subsequently after Charlemagne had his palatine chapel built there in the late 8th century and then made the city his empire's capital. As a spa city, Aachen has the right to name itself Bad Aachen, but chooses not to, so it remains on the top of alphabetical lists. Aachen's name in French and German evolved in parallel. The city is known by a variety of different names in other languages: Dialect Aachen is at the western end of the Benrath line that divides High German to the south from the rest of the West Germanic speech area to the north. Aachen's local dialect is called and belongs to the Ripuarian language. Middle Ages
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1520_3
Middle Ages After Roman times, Pepin the Short had a castle residence built in the town, due to the proximity of the hot springs and also for strategic reasons as it is located between the Rhineland and northern France. Einhard mentions that in 765–6 Pepin spent both Christmas and Easter at Aquis villa (), ("and [he] celebrated Christmas in the town Aquis, and similarly Easter") which must have been sufficiently equipped to support the royal household for several months. In the year of his coronation as king of the Franks, 768, Charlemagne came to spend Christmas at Aachen for the first time. He remained there in a mansion which he may have extended, although there is no source attesting to any significant building activity at Aachen in his time, apart from the building of the Palatine Chapel (since 1930, cathedral) and the Palace. Charlemagne spent most winters in Aachen between 792 and his death in 814. Aachen became the focus of his court and the political centre of his empire. After his death, the king was buried in the church which he had built; his original tomb has been lost, while his alleged remains are preserved in the Karlsschrein, the shrine where he was reburied after being declared a saint; his saintliness, however, was never officially acknowledged by the Roman Curia as such.
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1520_4
In 936, Otto I was crowned king of East Francia in the collegiate church built by Charlemagne. During the reign of Otto II, the nobles revolted and the West Franks under Lothair raided Aachen in 978. Aachen was attacked again by Odo of Champagne, who attacked the imperial palace while Conrad II was absent. Odo relinquished it quickly and was killed soon afterwards. The palace and town of Aachen had fortifying walls built by order of Emperor Frederick Barbarossa between 1172 and 1176. Over the next 500 years, most kings of Germany destined to reign over the Holy Roman Empire were crowned in Aachen. The original audience hall built by Charlemagne was torn down and replaced by the current city hall in 1330. The last king to be crowned here was Ferdinand I in 1531. During the Middle Ages, Aachen remained a city of regional importance, due to its proximity to Flanders; it achieved a modest position in the trade in woollen cloths, favoured by imperial privilege. The city remained a free imperial city, subject to the emperor only, but was politically far too weak to influence the policies of any of its neighbours. The only dominion it had was over Burtscheid, a neighbouring territory ruled by a Benedictine abbess. It was forced to accept that all of its traffic must pass through the "Aachener Reich". Even in the late 18th century the Abbess of Burtscheid was prevented from building a road linking her territory to the neighbouring estates of the duke of Jülich; the city of Aachen even deployed its handful of soldiers to chase away the road-diggers. As an imperial city, Aachen held certain political privileges that allowed it to remain independent of the troubles of Europe for many years. It remained a direct vassal of the Holy Roman Empire throughout most of the Middle Ages. It was also the site of many important church councils, including the Council of 837 and the Council of 1166, a council convened by the antipope Paschal III. Manuscript production
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1520_5
Manuscript production Aachen has proved an important site for the production of historical manuscripts. Under Charlemagne's purview, both the Ada Gospels and the Coronation Gospels may have been produced in Aachen. In addition, quantities of the other texts in the court library were also produced locally. During the reign of Louis the Pious (814–840), substantial quantities of ancient texts were produced at Aachen, including legal manuscripts such as the leges scriptorium group, patristic texts including the five manuscripts of the Bamberg Pliny Group. Finally, under Lothair I (840–855), texts of outstanding quality were still being produced. This however marked the end of the period of manuscript production at Aachen. 16th–18th centuries In 1598, following the invasion of Spanish troops from the Netherlands, Rudolf deposed all Protestant office holders in Aachen and even went as far as expelling them from the city. From the early 16th century, Aachen started to lose its power and influence. First the coronations of emperors were moved from Aachen to Frankfurt. This was followed by the religious wars and the great fire of 1656. After the destruction of most of the city in 1656, the rebuilding was mostly in the Baroque style. The decline of Aachen culminated in 1794, when the French, led by General Charles Dumouriez, occupied Aachen. In 1542, the Dutch humanist and physician Francis Fabricius published his study of the health benefits of the hot springs in Aachen. By the middle of the 17th century, the city had developed a considerable reputation as a spa, although this was in part because Aachen was then – and remained well into the 19th century – a place of high-level prostitution. Traces of this hidden agenda of the city's history are found in the 18th-century guidebooks to Aachen as well as to the other spas. The main indication for visiting patients, ironically, was syphilis; only by the end of the 19th century had rheumatism become the most important object of cures at Aachen and Burtscheid.
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1520_6
Aachen was chosen as the site of several important congresses and peace treaties: the first congress of Aachen (often referred to as the Congress of Aix-la-Chapelle in English) on 2 May 1668, leading to the First Treaty of Aachen in the same year which ended the War of Devolution. The second congress ended with the second treaty in 1748, ending the War of the Austrian Succession. In 1789, there was a constitutional crisis in the Aachen government, and in 1794 Aachen lost its status as a free imperial city. 19th century On 9 February 1801, the Peace of Lunéville removed the ownership of Aachen and the entire "left bank" of the Rhine from Germany (the Holy Roman Empire) and granted it to France. In 1815, control of the town was passed to the Kingdom of Prussia through an agreement reached by the Congress of Vienna. The third congress took place in 1818, to decide the fate of occupied Napoleonic France. By the middle of the 19th century, industrialisation had swept away most of the city's medieval rules of production and commerce, although the entirely corrupt remains of the city's medieval constitution were kept in place (compare the famous remarks of Georg Forster in his Ansichten vom Niederrhein) until 1801, when Aachen became the "chef-lieu du département de la Roer" in Napoleon's First French Empire. In 1815, after the Napoleonic Wars, the Kingdom of Prussia took over within the new German Confederation. The city was one of its most socially and politically backward centres until the end of the 19th century. Administered within the Rhine Province, by 1880 the population was 80,000. Starting in 1838, the railway from Cologne to Belgium passed through Aachen. The city suffered extreme overcrowding and deplorable sanitary conditions until 1875, when the medieval fortifications were finally abandoned as a limit to building and new, better housing was built in the east of the city, where sanitary drainage was easiest. In December 1880, the Aachen tramway network was opened, and in 1895 it was electrified. In the 19th century and up to the 1930s, the city was important in the production of railway locomotives and carriages, iron, pins, needles, buttons, tobacco, woollen goods, and silk goods. 20th century World War II
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1520_7
20th century World War II After World War I, Aachen was occupied by the Allies until 1930, along with the rest of German territory west of the Rhine. Aachen was one of the locations involved in the ill-fated Rhenish Republic. On 21 October 1923, an armed mob took over the city hall. Similar actions took place in Mönchen-Gladbach, Duisburg, and Krefeld. This republic lasted only about a year. Aachen was heavily damaged during World War II. According to Jörg Friedrich in The Fire (2008), two Allied air raids on 11 April and 24 May 1944 "radically destroyed" the city. The first killed 1,525, including 212 children, and bombed six hospitals. During the second, 442 aircraft hit two railway stations, killed 207, and left 15,000 homeless. The raids also destroyed Aachen-Eilendorf and Aachen-Burtscheid. The city and its fortified surroundings were laid siege to from 12 September to 21 October 1944 by the US 1st Infantry Division with the 3rd Armored Division assisting from the south. Around 13 October the US 2nd Armored Division played their part, coming from the north and getting as close as Würselen, while the 30th Infantry Division played a crucial role in completing the encirclement of Aachen on 16 October 1944. With reinforcements from the US 28th Infantry Division the Battle of Aachen continued involving direct assaults through the heavily defended city, which finally forced the German garrison to surrender on 21 October 1944. Aachen was the first German city to be captured by the Western Allies, and its residents welcomed the soldiers as liberators. What remained of the city was destroyed—in some areas completely—during the fighting, mostly by American artillery fire and demolitions carried out by the Waffen-SS defenders. Damaged buildings included the medieval churches of St. Foillan, St. Paul and St. Nicholas, and the Rathaus (city hall), although Aachen Cathedral was largely unscathed. Only 4,000 inhabitants remained in the city; the rest had followed evacuation orders. Its first Allied-appointed mayor, Franz Oppenhoff, was assassinated by an SS commando unit. History of Aachen Jews
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1520_8
History of Aachen Jews During the Roman period, Aachen was the site of a flourishing Jewish community. Later, during the Carolingian empire, a Jewish community lived near the royal palace. In 797, Isaac, a Jewish merchant, accompanied two ambassadors of Charlemagne to the court of Harun al-Rashid. He returned to Aachen in July 802, bearing an elephant called Abul-Abbas as a gift for the emperor. During the 13th century, many Jews converted to Christianity, as shown in the records of the Aachen Minster (today's Cathedral). In 1486, the Jews of Aachen offered gifts to Maximilian I during his coronation ceremony. In 1629, the Aachen Jewish community was expelled from the city. In 1667, six Jews were allowed to return. Most of the Aachen Jews settled in the nearby town of Burtscheid. On 16 May 1815, the Jewish community of the city offered an homage in its synagogue to the Prussian king, Friedrich Wilhelm III. A Jewish cemetery was acquired in 1851. 1,345 Jews lived in the city in 1933. The synagogue was destroyed during Kristallnacht in 1938. In 1939, after emigration and arrests, 782 Jews remained in the city. After World War II, only 62 Jews lived there. In 2003, 1,434 Jews were living in Aachen. In Jewish texts, the city of Aachen was called Aish or Ash (אש). 21st century The city of Aachen has developed into a technology hub as a by-product of hosting one of the leading universities of technology in Germany with the RWTH Aachen (Rheinisch-Westfälische Technische Hochschule), known especially for mechanical engineering, automotive and manufacturing technology as well as for its research and academic hospital Klinikum Aachen, one of the largest medical facilities in Europe. Geography
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1520_9
Geography Aachen is located in the middle of the Meuse–Rhine Euroregion, close to the border tripoint of Germany, the Netherlands, and Belgium. The town of Vaals in the Netherlands lies nearby at about from Aachen's city centre, while the Dutch city of Heerlen and Eupen, the capital of the German-speaking Community of Belgium, are both located about from Aachen city centre. Aachen lies near the head of the open valley of the Wurm (which today flows through the city in canalised form), part of the larger basin of the Meuse, and about north of the High Fens, which form the northern edge of the Eifel uplands of the Rhenish Massif. The maximum dimensions of the city's territory are from north to south, and from east to west. The city limits are long, of which border Belgium and the Netherlands. The highest point in Aachen, located in the far southeast of the city, lies at an elevation of above sea level. The lowest point, in the north, and on the border with the Netherlands, is at . Climate As the westernmost city in Germany (and close to the Low Countries), Aachen and the surrounding area belongs to a temperate climate zone (Cfb), with humid weather, mild winters, and warm summers. Because of its location north of the Eifel and the High Fens and its subsequent prevailing westerly weather patterns, rainfall in Aachen (on average 805 mm/year) is comparatively higher than, for example, in Bonn (with 669 mm/year). Another factor in the local weather forces of Aachen is the occurrence of Foehn winds on the southerly air currents, which results from the city's geographic location on the northern edge of the Eifel. Because the city is surrounded by hills, it suffers from inversion-related smog. Some areas of the city have become urban heat islands as a result of poor heat exchange, both because of the area's natural geography and from human activity. The city's numerous cold air corridors, which are slated to remain as free as possible from new construction, therefore play an important role in the urban climate of Aachen. The January average is , while the July average is . Precipitation is almost evenly spread throughout the year. Geology
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1520_10
Geology The geology of Aachen is very structurally heterogeneous. The oldest occurring rocks in the area surrounding the city originate from the Devonian period and include carboniferous sandstone, greywacke, claystone and limestone. These formations are part of the Rhenish Massif, north of the High Fens. In the Pennsylvanian subperiod of the Carboniferous geological period, these rock layers were narrowed and folded as a result of the Variscan orogeny. After this event, and over the course of the following 200 million years, this area has been continuously flattened. During the Cretaceous period, the ocean penetrated the continent from the direction of the North Sea up to the mountainous area near Aachen, bringing with it clay, sand, and chalk deposits. While the clay (which was the basis for a major pottery industry in nearby Raeren) is mostly found in the lower areas of Aachen, the hills of the Aachen Forest and the Lousberg were formed from upper Cretaceous sand and chalk deposits. More recent sedimentation is mainly located in the north and east of Aachen and was formed through tertiary and quaternary river and wind activities. Along the major thrust fault of the Variscan orogeny, there are over 30 thermal springs in Aachen and Burtscheid. Additionally, the subsurface of Aachen is traversed by numerous active faults that belong to the Rurgraben fault system, which has been responsible for numerous earthquakes in the past, including the 1756 Düren earthquake and the 1992 Roermond earthquake, which was the strongest earthquake ever recorded in the Netherlands. Demographics Aachen has 245,885 inhabitants (as of 31 December 2015), of whom 118,272 are female, and 127,613 are male. The unemployment rate in the city is, as of April 2012, 9.7 percent. At the end of 2009, the foreign-born residents of Aachen made up 13.6 percent of the total population. A significant portion of foreign residents are students at the RWTH Aachen University. Boroughs The city is divided into seven administrative districts, or boroughs, each with its own district council, district leader, and district authority. The councils are elected locally by those who live within the district, and these districts are further subdivided into smaller sections for statistical purposes, with each sub-district named by a two-digit number.
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1520_11
The districts of Aachen, including their constituent statistical districts, are: Aachen-Mitte: 10 Markt, 13 Theater, 14 Lindenplatz, 15 St. Jakob, 16 Westpark, 17 Hanbruch, 18 Hörn, 21 Ponttor, 22 Hansemannplatz, 23 Soers, 24 Jülicher Straße, 25 Kalkofen, 31 Kaiserplatz, 32 Adalbertsteinweg, 33 Panneschopp, 34 Rothe Erde, 35 Trierer Straße, 36 Frankenberg, 37 Forst, 41 Beverau, 42 Burtscheid Kurgarten, 43 Burtscheid Abbey, 46 Burtscheid Steinebrück, 47 Marschiertor, 48 Hangeweiher Brand: 51 Brand Eilendorf: 52 Eilendorf Haaren: 53 Haaren (including Verlautenheide) Kornelimünster/Walheim: 61 Kornelimünster, 62 Oberforstbach, 63 Walheim Laurensberg: 64 Vaalserquartier, 65 Laurensberg Richterich: 88 Richterich Regardless of official statistical designations, there are 50 neighbourhoods and communities within Aachen, here arranged by district: Aachen-Mitte: Beverau, Bildchen, Burtscheid, Forst, Frankenberg, Grüne Eiche, Hörn, Lintert, Pontviertel, Preuswald, Ronheide, Rosviertel, Rothe Erde, Stadtmitte, Steinebrück, West Brand: Brand, Eich, Freund, Hitfeld, Niederforstbach Eilendorf: Eilendorf, Nirm Haaren: Haaren, Hüls, Verlautenheide Kornelimünster/Walheim: Friesenrath, Hahn, Kitzenhaus, Kornelimünster, Krauthausen, Lichtenbusch, Nütheim, Oberforstbach, Sief, Schleckheim, Schmithof, Walheim Laurensberg: Gut Kullen, Kronenberg, Laurensberg, Lemiers, Melaten, Orsbach, Seffent, Soers, Steppenberg, Vaalserquartier, Vetschau Richterich: Horbach, Huf, Richterich
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1520_12
Neighbouring communities The following cities and communities border Aachen, clockwise from the northwest: Herzogenrath, Würselen, Eschweiler, Stolberg and Roetgen (which are all in the district of Aachen); Raeren, Kelmis and Plombières (Liège Province in Belgium) as well as Vaals, Gulpen-Wittem, Simpelveld, Heerlen and Kerkrade (all in Limburg Province in the Netherlands). Politics Mayor The current Mayor of Aachen is Sibylle Keupen, an independent endorsed by Alliance 90/The Greens, since 2020. The most recent mayoral election was held on 13 September 2020, with a runoff held on 27 September, and the results were as follows:
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1520_13
! rowspan=2 colspan=2| Candidate ! rowspan=2| Party ! colspan=2| First round ! colspan=2| Second round |- ! Votes ! % ! Votes ! % |- | bgcolor=| | align=left| Sibylle Keupen | align=left| Independent (Green) | 39,662 | 38.9 | 53,685 | 67.4 |- | bgcolor=| | align=left| Harald Baal | align=left| Christian Democratic Union | 25,253 | 24.8 | 26,003 | 32.6 |- | bgcolor=| | align=left| Mathias Dopatka | align=left| Social Democratic Party | 23,031 | 22.6 |- | bgcolor=| | align=left| Markus Mohr | align=left| Alternative for Germany | 3,387 | 3.3 |- | bgcolor=| | align=left| Wilhelm Helg | align=left| Free Democratic Party | 3,122 | 3.1 |- | bgcolor=| | align=left| Leo Deumens | align=left| The Left | 2,397 | 2.4 |- | bgcolor=| | align=left| Hubert vom Venn
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1520_14
| align=left| Hubert vom Venn | align=left| Die PARTEI | 2,112 | 2.1 |- | bgcolor=| | align=left| Jörg Polzin | align=left| Independent | 938 | 0.9 |- | | align=left| Ralf Haupts | align=left| Independent Voters' Association Aachen | 932 | 0.9 |- | bgcolor=| | align=left| Matthias Achilles | align=left| Pirate Party Germany | 848 | 0.8 |- | bgcolor=| | align=left| Adonis Böving | align=left| Independent | 317 | 0.3 |- ! colspan=3| Valid votes ! 101,999 ! 99.2 ! 79,688 ! 99.3 |- ! colspan=3| Invalid votes ! 819 ! 0.8 ! 532 ! 0.7 |- ! colspan=3| Total ! 102,818 ! 100.0 ! 80,220 ! 100.0 |- ! colspan=3| Electorate/voter turnout ! 192,502 ! 53.4 ! 192,435 ! 41.7 |- | colspan=7| Source: State Returning Officer |}
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1520_15
City council The Aachen city council governs the city alongside the Mayor. The most recent city council election was held on 13 September 2020, and the results were as follows:
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1520_16
! colspan=2| Party ! Votes ! % ! +/- ! Seats ! +/- |- | bgcolor=| | align=left| Alliance 90/The Greens (Grüne) | 34,712 | 34.1 | 17.5 | 20 | 7 |- | bgcolor=| | align=left| Christian Democratic Union (CDU) | 25,268 | 24.8 | 11.5 | 14 | 14 |- | bgcolor=| | align=left| Social Democratic Party (SPD) | 18,676 | 18.3 | 7.7 | 11 | 9 |- | bgcolor=| | align=left| Free Democratic Party (FDP) | 5,042 | 4.9 | 0.5 | 3 | ±0 |- | bgcolor=| | align=left| The Left (Die Linke) | 4,694 | 4.6 | 1.5 | 3 | 2 |- | bgcolor=| | align=left| Alternative for Germany (AfD) | 3,816 | 3.7 | 1.2 | 2 | ±0 |- | bgcolor=| | align=left| Volt Germany (Volt) | 3,784
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1520_17
| 3,784 | 3.7 | New | 2 | New |- | bgcolor=| | align=left| Die PARTEI (PARTEI) | 2,295 | 2.3 | 1.8 | 1 | 1 |- | | align=left| Independent Voters' Association Aachen (UWG) | 1,632 | 1.6 | 0.2 | 1 | ±0 |- | bgcolor=| | align=left| Pirate Party Germany (Piraten) | 1,226 | 1.2 | 2.2 | 1 | 2 |- | colspan=7 bgcolor=lightgrey| |- | bgcolor=| | align=left| Ecological Democratic Party (ÖDP) | 673 | 0.7 | New | 0 | New |- | | align=left| Voter Group | 45 | 0.0 | New | 0 | New |- ! colspan=2| Valid votes ! 101,863 ! 99.1 ! ! ! |- ! colspan=2| Invalid votes ! 918 ! 0.9 ! ! ! |- ! colspan=2| Total ! 102,781
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1520_18
! 102,781 ! 100.0 ! ! 58 ! 18 |- ! colspan=2| Electorate/voter turnout ! 192,502 ! 53.4 ! 0.7 ! ! |- | colspan=7| Source: State Returning Officer |}
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1520_19
Main sights Cathedral Aachen Cathedral was erected on the orders of Charlemagne. Construction began c. AD 796, and it was, on completion c. 798, the largest cathedral north of the Alps. It was modelled after the Basilica of San Vitale, in Ravenna, Italy, and was built by Odo of Metz. Charlemagne also desired for the chapel to compete with the Lateran Palace, both in quality and authority. It was originally built in the Carolingian style, including marble covered walls, and mosaic inlay on the dome. On his death, Charlemagne's remains were interred in the cathedral and can be seen there to this day. The cathedral was extended several times in later ages, turning it into a curious and unique mixture of building styles. The throne and gallery portion date from the Ottonian, with portions of the original opus sectile floor still visible. The 13th century saw gables being added to the roof, and after the fire of 1656, the dome was rebuilt. Finally, a choir was added around the start of the 15th century. After Frederick Barbarossa canonised Charlemagne in 1165 the chapel became a destination for pilgrims. For 600 years, from 936 to 1531, Aachen Cathedral was the church of coronation for 30 German kings and 12 queens. The church built by Charlemagne is still the main attraction of the city. In addition to holding the remains of its founder, it became the burial place of his successor Otto III. In the upper chamber of the gallery, Charlemagne's marble throne is housed. Aachen Cathedral has been designated as a UNESCO World Heritage Site. Most of the marble and columns used in the construction of the cathedral were brought from Rome and Ravenna, including the sarcophagus in which Charlemagne was eventually laid to rest. A bronze bear from Gaul was placed inside, along with an equestrian statue from Ravenna, believed to be Theodric, in contrast to a wolf and a statue of Marcus Aurelius in the Capitoline. Bronze pieces such as the doors and railings, some of which have survived to present day, were cast in a local foundry. Finally, there is uncertainty surrounding the bronze pine cone in the chapel, and where it was created. Wherever it was made, it was also a parallel to a piece in Rome, this in Old St. Peter's Basilica. Cathedral Treasury
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1520_20
Cathedral Treasury Aachen Cathedral Treasury has housed, throughout its history, a collection of liturgical objects. The origin of this church treasure is in dispute as some say Charlemagne himself endowed his chapel with the original collection, while the rest were collected over time. Others say all of the objects were collected over time, from such places as Jerusalem and Constantinople. The location of this treasury has moved over time and was unknown until the 15th century when it was located in the Matthiaskapelle (St. Matthew's Chapel) until 1873, when it was moved to the Karlskapelle (Charles' Chapel). From there it was moved to the Hungarian Chapel in 1881 and in 1931 to its present location next to the Allerseelenkapelle (Poor Souls' Chapel). Only six of the original Carolingian objects have remained, and of those only three are left in Aachen: the Aachen Gospels, a diptych of Christ, and an early Byzantine silk. The Coronation Gospels and a reliquary burse of St. Stephen were moved to Vienna in 1798 and the Talisman of Charlemagne was given as a gift in 1804 to Josephine Bonaparte and subsequently to Rheims Cathedral. 210 documented pieces have been added to the treasury since its inception, typically to receive in return legitimisation of linkage to the heritage of Charlemagne. The Lothar Cross, the Gospels of Otto III and multiple additional Byzantine silks were donated by Otto III. Part of the Pala d'Oro and a covering for the Aachen Gospels were made of gold donated by Henry II. Frederick Barbarossa donated the candelabrum that adorns the dome and also once "crowned" the Shrine of Charlemagne, which was placed underneath in 1215. Charles IV donated a pair of reliquaries. Louis XI gave, in 1475, the crown of Margaret of York, and, in 1481, another arm reliquary of Charlemagne. Maximilian I and Charles V both gave numerous works of art by Hans von Reutlingen. Continuing the tradition, objects continued to be donated until the present, each indicative of the period of its gifting, with the last documented gift being a chalice from 1960 made by Ewald Mataré. Rathaus
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1520_21
Rathaus The Aachen Rathaus, (English: Aachen City Hall or Aachen Town Hall) dated from 1330, lies between two central squares, the Markt (marketplace) and the Katschhof (between city hall and cathedral). The coronation hall is on the first floor of the building. Inside one can find five frescoes by the Aachen artist Alfred Rethel which show legendary scenes from the life of Charlemagne, as well as Charlemagne's signature. Also, precious replicas of the Imperial Regalia are kept here. Since 2009, the city hall has been a station on the Route Charlemagne, a tour programme by which historical sights of Aachen are presented to visitors. At the city hall, a museum exhibition explains the history and art of the building and gives a sense of the historical coronation banquets that took place there. A portrait of Napoleon from 1807 by Louis-André-Gabriel Bouchet and one of his wife Joséphine from 1805 by Robert Lefèvre are viewable as part of the tour. As before, the city hall is the seat of the mayor of Aachen and of the city council, and annually the Charlemagne Prize is awarded there. Other sights The Grashaus, a late medieval house at the Fischmarkt, is one of the oldest non-religious buildings in central Aachen. It hosted the city archive, and before that, the Grashaus was the city hall until the present building took over this function. The Elisenbrunnen is one of the most famous sights of Aachen. It is a neo-classical hall covering one of the city's famous fountains. It is just a minute away from the cathedral. Just a few steps in a south-easterly direction lies the 19th-century theatre. Also of note are two remaining city gates, the Ponttor (Pont gate), northwest of the cathedral, and the Marschiertor (marching gate), close to the central railway station. There are also a few parts of both medieval city walls left, most of them integrated into more recent buildings, but some others still visible. There are even five towers left, some of which are used for housing.
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1520_22
St. Michael's Church, Aachen was built as a church of the Aachen Jesuit Collegium in 1628. It is attributed to the Rhine mannerism, and a sample of a local Renaissance architecture. The rich façade remained unfinished until 1891, when the architect Peter Friedrich Peters added to it. The church is a Greek Orthodox church today, but the building is used also for concerts because of its good acoustics. The synagogue in Aachen, which was destroyed on the Night of Broken Glass (Kristallnacht), 9 November 1938, was reinaugurated on 18 May 1995. One of the contributors to the reconstructions of the synagogue was Jürgen Linden, the Lord Mayor of Aachen from 1989 to 2009. There are numerous other notable churches and monasteries, a few remarkable 17th- and 18th-century buildings in the particular Baroque style typical of the region, a synagogue, a collection of statues and monuments, park areas, cemeteries, among others. Among the museums in the town are the Suermondt-Ludwig Museum, which has a fine sculpture collection and the Aachen Museum of the International Press, which is dedicated to newspapers from the 16th century to the present. The area's industrial history is reflected in dozens of 19th- and early 20th-century manufacturing sites in the city. Economy Aachen is the administrative centre for the coal-mining industries in neighbouring places to the northeast. Products manufactured in Aachen include electrical goods, textiles, foodstuffs (chocolate and candy), glass, machinery, rubber products, furniture, metal products. Also in and around Aachen chemicals, plastics, cosmetics, and needles and pins are produced. Though once a major player in Aachen's economy, today glassware and textile production make up only 10% of total manufacturing jobs in the city. There have been a number of spin-offs from the university's IT technology department. Electric vehicle manufacturing
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1520_23
Electric vehicle manufacturing In June 2010, Achim Kampker, together with Günther Schuh, founded a small company to develop Street Scooter GmbH; in August 2014, it was renamed StreetScooter GmbH. This was a privately organised research initiative at the RWTH Aachen University which later became an independent company in Aachen. Kampker was also the founder and chairman of the European Network for Affordable and Sustainable Electromobility. In May 2014, the company announced that the city of Aachen, the city council Aachen and the savings bank Aachen had ordered electric vehicles from the company. In late 2014, approximately 70 employees were manufacturing 200 vehicles annually in the premises of the Waggonfabrik Talbot, the former Talbot/Bombardier plant in Aachen. In December 2014 Deutsche Post DHL Group purchased the StreetScooter company, which became its wholly owned subsidiary. By April 2016, the company announced that it would produce 2000 of its electric vans branded Work in Aachen by the end of the year. In 2015, the electric vehicle start-up e.GO Mobile was founded by Günther Schuh, which started producing the e.GO Life electric passenger car and other vehicles in April 2019. In April 2016, StreetScooter GmbH announced that it would be scaling up to manufacture approximately 10,000 of the Work vehicles annually, starting in 2017, also in Aachen. If that goal is achieved, it will become the largest electric light utility vehicle manufacturer in Europe, surpassing Renault which makes the smaller Kangoo Z.E.. Culture
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1520_24
Culture In 1372, Aachen became the first coin-minting city in the world to regularly place an Anno Domini date on a general circulation coin, a groschen. The Scotch Club in Aachen was the first discothèque in Germany, opened from 19 October 1959 until 1992. Klaus Quirini as DJ Heinrich was the first DJ ever. The thriving Aachen black metal scene is among the most notable in Germany, with such bands as Nagelfar, The Ruins of Beverast, Graupel and Verdunkeln. The local speciality of Aachen is an originally hard type of sweet bread, baked in large flat loaves, called Aachener Printen. Unlike Lebkuchen, a German form of gingerbread sweetened with honey, Printen use a syrup made from sugar. Today, a soft version is sold under the same name which follows an entirely different recipe. Asteroid 274835 Aachen, discovered by amateur astronomer Erwin Schwab in 2009, was named after the city. The official was published by the Minor Planet Center on 8 November 2019 (). Education RWTH Aachen University, established as Polytechnicum in 1870, is one of Germany's Universities of Excellence with strong emphasis on technological research, especially for electrical and mechanical engineering, computer sciences, physics, and chemistry. The university clinic attached to the RWTH, the Klinikum Aachen, is the biggest single-building hospital in Europe. Over time, a host of software and computer industries have developed around the university. It also maintains a botanical garden (the Botanischer Garten Aachen). FH Aachen, Aachen University of Applied Sciences (AcUAS) was founded in 1971. The AcUAS offers a classic engineering education in professions such as mechatronics, construction engineering, mechanical engineering or electrical engineering. German and international students are educated in more than 20 international or foreign-oriented programmes and can acquire German as well as international degrees (Bachelor/Master) or Doppelabschlüsse (double degrees). Foreign students account for more than 21% of the student body.
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1520_25
The Katholische Hochschule Nordrhein-Westfalen – Abteilung Aachen (Catholic University of Applied Sciences Northrhine-Westphalia – Aachen department) offers its some 750 students a variety of degree programmes: social work, childhood education, nursing, and co-operative management. It also has the only programme of study in Germany especially designed for mothers. The Hochschule für Musik und Tanz Köln (Cologne University of Music) is one of the world's foremost performing arts schools and one of the largest music institutions for higher education in Europe with one of its three campuses in Aachen. The Aachen campus substantially contributes to the Opera/Musical Theatre master's programme by collaborating with the Theater Aachen and the recently established musical theatre chair through the Rheinische Opernakademie. The German army's Technical School (Ausbildungszentrum Technik Landsysteme) is in Aachen. Sports The annual CHIO (short for the French term Concours Hippique International Officiel) is the biggest equestrian meeting of the world and among horsemen is considered to be as prestigious for equitation as the tournament of Wimbledon for tennis. Aachen hosted the 2006 FEI World Equestrian Games. The local football team Alemannia Aachen had a short run in Germany's first division, after its promotion in 2006. However, the team could not sustain its status and is now back in the fourth division. The stadium "Tivoli", opened in 1928, served as the venue for the team's home games and was well known for its incomparable atmosphere throughout the whole of the second division. Before the old stadium's demolition in 2011, it was used by amateurs, whilst the Bundesliga Club held its games in the new stadium "Neuer Tivoli" – meaning New Tivoli—a couple of metres down the road. The building work for the stadium which has a capacity of 32,960, began in May 2008 and was completed by the beginning of 2009. The Ladies in Black women's volleyball team (part of the "PTSV Aachen" sports club since 2013) has played in the first German volleyball league (DVL) since 2008. Transport
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1520_26
Transport Rail Aachen's railway station, the Hauptbahnhof (Central Station), was constructed in 1841 for the Cologne–Aachen railway line. In 1905 it was moved closer to the city centre. It serves main lines to Cologne, Mönchengladbach and Liège as well as branch lines to Heerlen, Alsdorf, Stolberg and Eschweiler. ICE high speed trains from Brussels via Cologne to Frankfurt am Main and Thalys trains from Paris to Cologne also stop at Aachen Central Station. Four RE lines and two RB lines connect Aachen with the Ruhrgebiet, Mönchengladbach, Spa (Belgium), Düsseldorf and the Siegerland. The Euregiobahn, a regional railway system, reaches several minor cities in the Aachen region. There are four smaller stations in Aachen: Aachen West, Aachen Schanz, Aachen-Rothe Erde and Eilendorf. Slower trains stop at these. Aachen West has gained in importance with the expansion of RWTH Aachen University. Intercity bus stations There are two stations for intercity bus services in Aachen: Aachen West station, in the north-west of the city, and Aachen Wilmersdorfer Straße, in the north-east. Public transport The first horse tram line in Aachen opened in December 1880. After electrification in 1895, it attained a maximum length of in 1915, becoming the fourth-longest tram network in Germany. Many tram lines extended to the surrounding towns of Herzogenrath, Stolberg, Alsdorf as well as the Belgian and Dutch communes of Vaals, Kelmis (then Altenberg) and Eupen. The Aachen tram system was linked with the Belgian national interurban tram system. Like many tram systems in Western Europe, the Aachen tram suffered from poorly-maintained infrastructure and was so deemed unnecessary and disrupting for car drivers by local politics. On 28 September 1974 the last line 15 (Vaals–Brand) operated for one last day and was then replaced by buses. A proposal to reinstate a tram/light rail system under the name Campusbahn was dropped after a referendum.
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1520_27
Today, the ASEAG (Aachener Straßenbahn und Energieversorgungs-AG, literally "Aachen tram and power supply company") operates a bus network with 68 bus routes. Because of the location at the border, many bus routes extend to Belgium and the Netherlands. Lines 14 to Eupen, Belgium and 44 to Heerlen, Netherlands are jointly operated with Transport en Commun and Veolia Transport Nederland, respectively. ASEAG is one of the main participants in the Aachener Verkehrsverbund (AVV), a tariff association in the region. Along with ASEAG, city bus routes of Aachen are served by private contractors such as Sadar, Taeter, Schlömer, or DB Regio Bus. Line 350, which runs from Maastricht, also enters Aachen. Roads Aachen is connected to the Autobahn A4 (west-east), A44 (north-south) and A544 (a smaller motorway from the A4 to the Europaplatz near the city centre). There are plans to eliminate traffic jams at the Aachen road interchange. Airport Maastricht Aachen Airport is the main airport of Aachen and Maastricht. It is located around 15 nautical miles (28 km; 17 mi) northwest of Aachen. There is a shuttle-service between Aachen and the airport. Recreational aviation is served by the (formerly military) Aachen Merzbrück Airfield. Charlemagne Prize Since 1950, a committee of Aachen citizens annually awards the Charlemagne Prize () to personalities of outstanding service to the unification of Europe. It is traditionally awarded on Ascension Day at the City Hall. In 2016, the Charlemagne Award was awarded to Pope Francis. The International Charlemagne Prize of Aachen was awarded in the year 2000 to US president Bill Clinton, for his special personal contribution to co-operation with the states of Europe, for the preservation of peace, freedom, democracy and human rights in Europe, and for his support of the enlargement of the European Union. In 2004, Pope John Paul II's efforts to unite Europe were honoured with an "Extraordinary Charlemagne Medal", which was awarded for the only time ever.
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1520_28
Literature Aix is the destination in Robert Browning's poem "How They Brought the Good News from Ghent to Aix", which was published in Dramatic Romances and Lyrics, 1845. The poem is a first-person narrative told, in breathless galloping meter, by one of three riders; an urgent midnight errand to deliver —"the news which alone could save Aix from her fate". Notable people Twin towns – sister cities Aachen is twinned with: Montebourg, France (1960) Reims, France (1967) Halifax, England (1979) Toledo, Spain (1985) Ningbo, China (1986) Naumburg, Germany (1988) Arlington County, United States (1993) Kostroma, Russia (2005) Sarıyer, Istanbul, Turkey (2013) Cape Town, South Africa (2017) See also Aachen (district) Aachen Prison Aachen tram Aachener Aachener Chronik Aachener Bachverein List of mayors of Aachen Council of Aachen Treaty of Aix-la-Chapelle (disambiguation) Maastricht Aachen Airport Notes References Sources Further reading External links Aachen (district) Belgium–Germany border crossings Catholic pilgrimage sites Cities in North Rhine-Westphalia 1st century Free imperial cities Jewish German history Matter of France Populated places established in the 1st century Rhineland Roman towns and cities in Germany 765 Spa towns in Germany
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1523_0
Agate () is a common rock formation, consisting of chalcedony and quartz as its primary components, with a wide variety of colors. Agates are primarily formed within volcanic and metamorphic rocks. The ornamental use of agate dates back to Ancient Greece in assorted jewelry and in the seal stones of Greek warriors. Use of beads necklaces with pierced and polished agate goes further back to the 3rd millennium BCE in the Indus Valley Civilisation. Etymology and history The stone was given its name by Theophrastus, a Greek philosopher and naturalist, who discovered the stone along the shore line of the Dirillo River or Achates () in Sicily, sometime between the 4th and 3rd centuries BCE. Ancient use Agate is one of the most common materials used in the art of hardstone carving, and has been recovered at a number of ancient sites, indicating its widespread use in the ancient world; for example, archaeological recovery at the Knossos site on Crete illustrates its role in Bronze Age Minoan culture. Formation and characteristics Agate minerals have the tendency to form on or within pre-existing rocks, creating difficulties in accurately determining their time of formation. Their host rocks have been dated to have formed as early as the Archean Eon. Agates are most commonly found as nodules within the cavities of volcanic rocks. These cavities are formed from the gases trapped within the liquid volcanic material forming vesicles. Cavities are then filled in with silica-rich fluids from the volcanic material, layers are deposited on the walls of the cavity slowly working their way inwards. The first layer deposited on the cavity walls is commonly known as the priming layer. Variations in the character of the solution or in the conditions of deposition may cause a corresponding variation in the successive layers. These variations in layers result in bands of chalcedony, often alternating with layers of crystalline quartz forming banded agate. Hollow agates can also form due to the deposition of liquid-rich silica not penetrating deep enough to fill the cavity completely. Agate will form crystals within the reduced cavity, and the apex of each crystal may point towards the center of the cavity.
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1523_1
The priming layer is often dark green, but can be modified by iron oxide resulting in a rust like appearance. Agate is a very durable and therefore is often seen detached from its eroding matrix, once removed, the outer surface is usually pitted and rough from filling the cavity of its former matrix. Agates have also been found in sedimentary rocks, normally in limestone or dolomite; these sedimentary rocks acquire cavities often from decomposed branches or other buried organic material. If silica-rich fluids are able to penetrate into these cavities agates can be formed. Types Lace agate is a variety that exhibits a lace-like pattern with forms such as eyes, swirls, bands or zigzags. Blue lace agate is found in Africa and is especially hard. Crazy lace agate, typically found in Mexico, is often brightly colored with a complex pattern, demonstrating randomized distribution of contour lines and circular droplets, scattered throughout the rock. The stone is typically coloured red and white but is also seen to exhibit yellow and grey combinations as well. Moss agate, as the name suggests, exhibits a moss-like pattern and is of a greenish colour. The coloration is not created by any vegetative growth, but rather through the mixture of chalcedony and oxidized iron hornblende. Dendritic agate also displays vegetative features, including fern-like patterns formed due to the presence of manganese and iron oxides. Turritella agate (Elimia tenera) is formed from the shells of fossilized freshwater Turritella gastropods with elongated spiral shells. Similarly, coral, petrified wood, porous rocks and other organic remains can also form agate. Coldwater agates, such as the Lake Michigan cloud agate, did not form under volcanic processes, but instead formed within the limestone and dolomite strata of marine origin. Like volcanic-origin agates, Coldwater agates formed from silica gels that lined pockets and seams within the bedrock. These agates are typically less colorful, with banded lines of grey and white chalcedony. Greek agate is a name given to pale white to tan colored agate found in the former Greek colony of Sicily as early as 400 BCE. The Greeks used it for making jewelry and beads.
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1523_2
Brazilian agate is found as sizable geodes of layered nodules. These occur in brownish tones inter-layered with white and gray. It is often dyed in various colors for ornamental purposes. Polyhedroid agate forms in a flat-sided shape similar to a polyhedron. When sliced, it often shows a characteristic layering of concentric polygons. It has been suggested that growth is not crystallographically controlled but is due to the filling-in of spaces between pre-existing crystals which have since dissolved. Other forms of agate include Holley blue agate (also spelled "Holly blue agate"), a rare dark blue ribbon agate only found near Holley, Oregon; Lake Superior agate; Carnelian agate (has reddish hues); Botswana agate; plume agate; condor agate; tube agate containing visible flow channels or pinhole-sized "tubes"; fortification agate with contrasting concentric banding reminiscent of defensive ditches and walls around ancient forts; Binghamite, a variety found only on the Cuyuna iron range (near Crosby) in Crow Wing County, Minnesota; fire agate showing an iridescent, internal flash or "fire", the result of a layer of clear agate over a layer of hydrothermally deposited hematite; Patuxent River stone, a red and yellow form of agate only found in Maryland; enhydro agate contains tiny inclusions of water, sometimes with air bubbles. Uses in industry and art Industrial uses of agate exploit its hardness, ability to retain a highly polished surface finish and resistance to chemical attack. It has traditionally been used to make knife-edge bearings for laboratory balances and precision pendulums, and sometimes to make mortars and pestles to crush and mix chemicals. It has also been used for centuries for leather burnishing tools.
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1523_3
The decorative arts use it to make ornaments such as pins, brooches or other types of jewellery, paper knives, inkstands, marbles and seals. Agate is also still used today for decorative displays, cabochons, beads, carvings and Intarsia art as well as face-polished and tumble-polished specimens of varying size and origin. Idar-Oberstein was one of the centers which made use of agate on an industrial scale. Where in the beginning locally found agates were used to make all types of objects for the European market, this became a globalized business around the turn of the 20th century: Idar-Oberstein imported large quantities of agate from Brazil, as ship's ballast. Making use of a variety of proprietary chemical processes, they produced colored beads that were sold around the globe. Agates have long been used in arts and crafts. The sanctuary of a Presbyterian church in Yachats, Oregon, has six windows with panes made of agates collected from the local beaches. Health impact Respiratory diseases such as silicosis and higher incidence of tuberculosis among workers involved in the agate industry have been reported from India and China. See also Topaz Opal Notes References Cross, Brad L. and Zeitner, June Culp. Geodes: Nature's Treasures. Bardwin Park, California, Gem Guides Book Co. 2005. Hart, Gilbert "The Nomenclature of Silica", American Mineralogist, Volume 12, pages 383–395, 1927 International Colored Gemstone Association, "Agate: banded beauty" "Agate", Mindat.org, Hudson Institute of Mineralogy Moxon, Terry. Agate: Microstructure and Possible Origin. Doncaster, S. Yorks, UK, Terra Publications, 1996. Pabian, Roger, et al. Agates: Treasures of the Earth. Buffalo, New York, Firefly Books, 2006. Schumann, Walter. Gemstones of the World. 3rd edition. New York: Sterling, 2006. External links "Agates", School of Natural Resources, University of Nebraska-Lincoln (retrieved 27 December 2014). Hardstone carving Silicate minerals Symbols of South Dakota
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1525_0
Aspirin, also known as acetylsalicylic acid (ASA), is a medication used to reduce pain, fever, or inflammation. Specific inflammatory conditions which aspirin is used to treat include Kawasaki disease, pericarditis, and rheumatic fever. Aspirin given shortly after a heart attack decreases the risk of death. Aspirin is also used long-term to help prevent further heart attacks, ischaemic strokes, and blood clots in people at high risk. For pain or fever, effects typically begin within 30 minutes. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID) and works similarly to other NSAIDs but also suppresses the normal functioning of platelets. Aspirin, often used as an analgesic, anti-pyretic and non-steroidal anti-inflammatory drug (NSAID), is able to have an anti-platelet effect by inhibiting the COX activity in the platelet to prevent the production of thromboxane A2 which acts to bind platelets together during coagulation as well as cause vasoconstriction and bronchoconstriction. One common adverse effect is an upset stomach. More significant side effects include stomach ulcers, stomach bleeding, and worsening asthma. Bleeding risk is greater among those who are older, drink alcohol, take other NSAIDs, or are on other blood thinners. Aspirin is not recommended in the last part of pregnancy. It is not generally recommended in children with infections because of the risk of Reye syndrome. High doses may result in ringing in the ears. A precursor to aspirin found in leaves from the willow tree (genus Salix) has been used for its health effects for at least 2,400 years. In 1853, chemist Charles Frédéric Gerhardt treated the medicine sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time. For the next 50 years, other chemists established the chemical structure and devised more efficient production methods.
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1525_1
Aspirin is one of the most widely used medications globally, with an estimated (50 to 120 billion pills) consumed each year. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication. In 2019, it was the 38th most commonly prescribed medication in the United States, with more than 18million prescriptions. Brand vs. generic name In 1897, scientists at the Bayer company began studying acetylsalicylic acid as a less-irritating replacement medication for common salicylate medicines. By 1899, Bayer had named it "Aspirin" and sold it around the world. Aspirin's popularity grew over the first half of the 20th century, leading to competition between many brands and formulations. The word Aspirin was Bayer's brand name; however, their rights to the trademark were lost or sold in many countries. The name is ultimately a blend of the prefix a(cetyl) + spir Spiraea, the meadowsweet plant genus from which the acetylsalicylic acid was originally derived at Bayer + -in, the common chemical suffix. Chemical properties Aspirin decomposes rapidly in solutions of ammonium acetate or the acetates, carbonates, citrates, or hydroxides of the alkali metals. It is stable in dry air, but gradually hydrolyses in contact with moisture to acetic and salicylic acids. In solution with alkalis, the hydrolysis proceeds rapidly and the clear solutions formed may consist entirely of acetate and salicylate. Like flour mills, factories producing aspirin tablets must control the amount of the powder that becomes airborne inside the building, because the powder-air mixture can be explosive. The National Institute for Occupational Safety and Health (NIOSH) has set a recommended exposure limit in the United States of 5mg/m3 (time-weighted average). In 1989, the Occupational Safety and Health Administration (OSHA) set a legal permissible exposure limit for aspirin of 5mg/m3, but this was vacated by the AFL-CIO v. OSHA decision in 1993.
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1525_2
Synthesis The synthesis of aspirin is classified as an esterification reaction. Salicylic acid is treated with acetic anhydride, an acid derivative, causing a chemical reaction that turns salicylic acid's hydroxyl group into an ester group (R-OH → R-OCOCH3). This process yields aspirin and acetic acid, which is considered a byproduct of this reaction. Small amounts of sulfuric acid (and occasionally phosphoric acid) are almost always used as a catalyst. This method is commonly demonstrated in undergraduate teaching labs. Reaction mechanism Formulations containing high concentrations of aspirin often smell like vinegar because aspirin can decompose through hydrolysis in moist conditions, yielding salicylic and acetic acids. Physical properties Aspirin, an acetyl derivative of salicylic acid, is a white, crystalline, weakly acidic substance, with a melting point of , and a boiling point of . Its acid dissociation constant (pKa) is 3.5 at . Polymorphism Polymorphism, or the ability of a substance to form more than one crystal structure, is important in the development of pharmaceutical ingredients. Many drugs receive regulatory approval for only a single crystal form or polymorph. For a long time, only one crystal structure for aspirin was known. That aspirin might have a second crystalline form was suspected since the 1960s. The elusive second polymorph was first discovered by Vishweshwar and coworkers in 2005, and fine structural details were given by Bond et al. A new crystal type was found during experiments after co-crystallization of aspirin and levetiracetam from hot acetonitrile. The form II is only stable at 100K and reverts to form I at ambient temperature. In the (unambiguous) form I, two salicylic molecules form centrosymmetric dimers through the acetyl groups with the (acidic) methyl proton to carbonyl hydrogen bonds, and in the newly claimed form II, each salicylic molecule forms the same hydrogen bonds with two neighboring molecules instead of one. With respect to the hydrogen bonds formed by the carboxylic acid groups, both polymorphs form identical dimer structures. Mechanism of action
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1525_3
Mechanism of action Discovery of the mechanism In 1971, British pharmacologist John Robert Vane, then employed by the Royal College of Surgeons in London, showed aspirin suppressed the production of prostaglandins and thromboxanes. For this discovery he was awarded the 1982 Nobel Prize in Physiology or Medicine, jointly with Sune Bergström and Bengt Ingemar Samuelsson. Prostaglandins and thromboxanes Aspirin's ability to suppress the production of prostaglandins and thromboxanes is due to its irreversible inactivation of the cyclooxygenase (COX; officially known as prostaglandin-endoperoxide synthase, PTGS) enzyme required for prostaglandin and thromboxane synthesis. Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the PTGS enzyme (Suicide inhibition). This makes aspirin different from other NSAIDs (such as diclofenac and ibuprofen), which are reversible inhibitors. Low-dose aspirin use irreversibly blocks the formation of thromboxane A2 in platelets, producing an inhibitory effect on platelet aggregation during the lifetime of the affected platelet (8–9 days). This antithrombotic property makes aspirin useful for reducing the incidence of heart attacks in people who have had a heart attack, unstable angina, ischemic stroke or transient ischemic attack. 40mg of aspirin a day is able to inhibit a large proportion of maximum thromboxane A2 release provoked acutely, with the prostaglandin I2 synthesis being little affected; however, higher doses of aspirin are required to attain further inhibition. Prostaglandins, local hormones produced in the body, have diverse effects, including the transmission of pain information to the brain, modulation of the hypothalamic thermostat, and inflammation. Thromboxanes are responsible for the aggregation of platelets that form blood clots. Heart attacks are caused primarily by blood clots, and low doses of aspirin are seen as an effective medical intervention to prevent a second acute myocardial infarction.
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1525_4
COX-1 and COX-2 inhibition At least two different types of cyclooxygenases, COX-1 and COX-2, are acted on by aspirin. Aspirin irreversibly inhibits COX-1 and modifies the enzymatic activity of COX-2. COX-2 normally produces prostanoids, most of which are proinflammatory. Aspirin-modified PTGS2 (prostaglandin-endoperoxide synthase 2) produces lipoxins, most of which are anti-inflammatory. Newer NSAID drugs, COX-2 inhibitors (coxibs), have been developed to inhibit only PTGS2, with the intent to reduce the incidence of gastrointestinal side effects. Several COX-2 inhibitors, such as rofecoxib (Vioxx), have been withdrawn from the market, after evidence emerged that PTGS2 inhibitors increase the risk of heart attack and stroke. Endothelial cells lining the microvasculature in the body are proposed to express PTGS2, and, by selectively inhibiting PTGS2, prostaglandin production (specifically, PGI2; prostacyclin) is downregulated with respect to thromboxane levels, as PTGS1 in platelets is unaffected. Thus, the protective anticoagulative effect of PGI2 is removed, increasing the risk of thrombus and associated heart attacks and other circulatory problems. Since platelets have no DNA, they are unable to synthesize new PTGS once aspirin has irreversibly inhibited the enzyme, an important difference with reversible inhibitors.
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1525_5
Furthermore, aspirin, while inhibiting the ability of COX-2 to form pro-inflammatory products such as the prostaglandins, converts this enzyme's activity from a prostaglandin-forming cyclooxygenase to a lipoxygenase-like enzyme: aspirin-treated COX-2 metabolizes a variety of polyunsaturated fatty acids to hydroperoxy products which are then further metabolized to specialized proresolving mediators such as the aspirin-triggered lipoxins, aspirin-triggered resolvins, and aspirin-triggered maresins. These mediators possess potent anti-inflammatory activity. It is proposed that this aspirin-triggered transition of COX-2 from cyclooxygenase to lipoxygenase activity and the consequential formation of specialized proresolving mediators contributes to the anti-inflammatory effects of aspirin. Additional mechanisms Aspirin has been shown to have at least three additional modes of action. It uncouples oxidative phosphorylation in cartilaginous (and hepatic) mitochondria, by diffusing from the inner membrane space as a proton carrier back into the mitochondrial matrix, where it ionizes once again to release protons. Aspirin buffers and transports the protons. When high doses are given, it may actually cause fever, owing to the heat released from the electron transport chain, as opposed to the antipyretic action of aspirin seen with lower doses. In addition, aspirin induces the formation of NO-radicals in the body, which have been shown in mice to have an independent mechanism of reducing inflammation. This reduced leukocyte adhesion is an important step in the immune response to infection; however, evidence is insufficient to show aspirin helps to fight infection. More recent data also suggest salicylic acid and its derivatives modulate signalling through NF-κB. NF-κB, a transcription factor complex, plays a central role in many biological processes, including inflammation.
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1525_6
Aspirin is readily broken down in the body to salicylic acid, which itself has anti-inflammatory, antipyretic, and analgesic effects. In 2012, salicylic acid was found to activate AMP-activated protein kinase, which has been suggested as a possible explanation for some of the effects of both salicylic acid and aspirin. The acetyl portion of the aspirin molecule has its own targets. Acetylation of cellular proteins is a well-established phenomenon in the regulation of protein function at the post-translational level. Aspirin is able to acetylate several other targets in addition to COX isoenzymes. These acetylation reactions may explain many hitherto unexplained effects of aspirin. Pharmacokinetics Acetylsalicylic acid is a weak acid, and very little of it is ionized in the stomach after oral administration. Acetylsalicylic acid is quickly absorbed through the cell membrane in the acidic conditions of the stomach. The increased pH and larger surface area of the small intestine causes aspirin to be absorbed more slowly there, as more of it is ionized. Owing to the formation of concretions, aspirin is absorbed much more slowly during overdose, and plasma concentrations can continue to rise for up to 24 hours after ingestion. About 50–80% of salicylate in the blood is bound to human serum albumin, while the rest remains in the active, ionized state; protein binding is concentration-dependent. Saturation of binding sites leads to more free salicylate and increased toxicity. The volume of distribution is 0.1–0.2 L/kg. Acidosis increases the volume of distribution because of enhancement of tissue penetration of salicylates.
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1525_7
As much as 80% of therapeutic doses of salicylic acid is metabolized in the liver. Conjugation with glycine forms salicyluric acid, and with glucuronic acid to form two different glucuronide esters. The conjugate with the acetyl group intact is referred to as the acyl glucuronide; the deacetylated conjugate is the phenolic glucuronide. These metabolic pathways have only a limited capacity. Small amounts of salicylic acid are also hydroxylated to gentisic acid. With large salicylate doses, the kinetics switch from first-order to zero-order, as metabolic pathways become saturated and renal excretion becomes increasingly important. Salicylates are excreted mainly by the kidneys as salicyluric acid (75%), free salicylic acid (10%), salicylic phenol (10%), and acyl glucuronides (5%), gentisic acid (< 1%), and 2,3-dihydroxybenzoic acid. When small doses (less than 250mg in an adult) are ingested, all pathways proceed by first-order kinetics, with an elimination half-life of about 2.0 h to 4.5 h. When higher doses of salicylate are ingested (more than 4 g), the half-life becomes much longer (15 h to 30 h), because the biotransformation pathways concerned with the formation of salicyluric acid and salicyl phenolic glucuronide become saturated. Renal excretion of salicylic acid becomes increasingly important as the metabolic pathways become saturated, because it is extremely sensitive to changes in urinary pH. A 10- to 20-fold increase in renal clearance occurs when urine pH is increased from 5 to 8. The use of urinary alkalinization exploits this particular aspect of salicylate elimination. It was found that short-term aspirin use in therapeutic doses might precipitate reversible acute kidney injury when the patient was ill with glomerulonephritis or cirrhosis. Aspirin for some patients with chronic kidney disease and some children with congestive heart failure was contraindicated.
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1525_8
History Medicines made from willow and other salicylate-rich plants appear in clay tablets from ancient Sumer as well as the Ebers Papyrus from ancient Egypt. Hippocrates referred to the use of salicylic tea to reduce fevers around 400 BC, and willow bark preparations were part of the pharmacopoeia of Western medicine in classical antiquity and the Middle Ages. Willow bark extract became recognized for its specific effects on fever, pain, and inflammation in the mid-eighteenth century. By the nineteenth century, pharmacists were experimenting with and prescribing a variety of chemicals related to salicylic acid, the active component of willow extract. In 1853, chemist Charles Frédéric Gerhardt treated sodium salicylate with acetyl chloride to produce acetylsalicylic acid for the first time; in the second half of the 19th century, other academic chemists established the compound's chemical structure and devised more efficient methods of synthesis. In 1897, scientists at the drug and dye firm Bayer began investigating acetylsalicylic acid as a less-irritating replacement for standard common salicylate medicines, and identified a new way to synthesize it. By 1899, Bayer had dubbed this drug Aspirin and was selling it globally. The word Aspirin was Bayer's brand name, rather than the generic name of the drug; however, Bayer's rights to the trademark were lost or sold in many countries. Aspirin's popularity grew over the first half of the 20th century leading to fierce competition with the proliferation of aspirin brands and products. Aspirin's popularity declined after the development of acetaminophen/paracetamol in 1956 and ibuprofen in 1962. In the 1960s and 1970s, John Vane and others discovered the basic mechanism of aspirin's effects, while clinical trials and other studies from the 1960s to the 1980s established aspirin's efficacy as an anti-clotting agent that reduces the risk of clotting diseases. The initial large studies on the use of low-dose aspirin to prevent heart attacks that were published in the 1970s and 1980s helped spur reform in clinical research ethics and guidelines for human subject research and US federal law, and are often cited as examples of clinical trials that included only men, but from which people drew general conclusions that did not hold true for women.
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1525_9
Aspirin sales revived considerably in the last decades of the 20th century, and remain strong in the 21st century with widespread use as a preventive treatment for heart attacks and strokes. Trademark Bayer lost its trademark for Aspirin in the United States in actions taken between 1918 and 1921 because it had failed to use the name for its own product correctly and had for years allowed the use of "Aspirin" by other manufacturers without defending the intellectual property rights. Today, aspirin is a generic trademark in many countries. Aspirin, with a capital "A", remains a registered trademark of Bayer in Germany, Canada, Mexico, and in over 80 other countries, for acetylsalicylic acid in all markets, but using different packaging and physical aspects for each. Compendial status United States Pharmacopeia British Pharmacopoeia Medical use Aspirin is used in the treatment of a number of conditions, including fever, pain, rheumatic fever, and inflammatory conditions, such as rheumatoid arthritis, pericarditis, and Kawasaki disease. Lower doses of aspirin have also been shown to reduce the risk of death from a heart attack, or the risk of stroke in people who are at high risk or who have cardiovascular disease, but not in elderly people who are otherwise healthy. There is some evidence that aspirin is effective at preventing colorectal cancer, though the mechanisms of this effect are unclear. In the United States, low-dose aspirin is deemed reasonable in those between 50 and 70 years old who have a risk of cardiovascular disease over 10%, are not at an increased risk of bleeding, and are otherwise healthy. Pain
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1525_10
Pain Aspirin is an effective analgesic for acute pain, although it is generally considered inferior to ibuprofen because aspirin is more likely to cause gastrointestinal bleeding. Aspirin is generally ineffective for those pains caused by muscle cramps, bloating, gastric distension, or acute skin irritation. As with other NSAIDs, combinations of aspirin and caffeine provide slightly greater pain relief than aspirin alone. Effervescent formulations of aspirin relieve pain faster than aspirin in tablets, which makes them useful for the treatment of migraines. Topical aspirin may be effective for treating some types of neuropathic pain. Aspirin, either by itself or in a combined formulation, effectively treats certain types of a headache, but its efficacy may be questionable for others. Secondary headaches, meaning those caused by another disorder or trauma, should be promptly treated by a medical provider. Among primary headaches, the International Classification of Headache Disorders distinguishes between tension headache (the most common), migraine, and cluster headache. Aspirin or other over-the-counter analgesics are widely recognized as effective for the treatment of tension headache. Aspirin, especially as a component of an aspirin/paracetamol/caffeine combination, is considered a first-line therapy in the treatment of migraine, and comparable to lower doses of sumatriptan. It is most effective at stopping migraines when they are first beginning.
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1525_11
Fever Like its ability to control pain, aspirin's ability to control fever is due to its action on the prostaglandin system through its irreversible inhibition of COX. Although aspirin's use as an antipyretic in adults is well established, many medical societies and regulatory agencies, including the American Academy of Family Physicians, the American Academy of Pediatrics, and the Food and Drug Administration, strongly advise against using aspirin for treatment of fever in children because of the risk of Reye's syndrome, a rare but often fatal illness associated with the use of aspirin or other salicylates in children during episodes of viral or bacterial infection. Because of the risk of Reye's syndrome in children, in 1986, the US Food and Drug Administration (FDA) required labeling on all aspirin-containing medications advising against its use in children and teenagers. Inflammation Aspirin is used as an anti-inflammatory agent for both acute and long-term inflammation, as well as for treatment of inflammatory diseases, such as rheumatoid arthritis. Heart attacks and strokes Aspirin is an important part of the treatment of those who have had a heart attack. It is generally not recommended for routine use by people with no other health problems, including those over the age of 70.
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1525_12
For people who have already had a heart attack or stroke, taking aspirin daily for two years prevented 1 in 50 from having a cardiovascular problem (heart attack, stroke, or death), but also caused non-fatal bleeding problems to occur in 1 of 400 people. Data from early trials of aspirin in primary prevention suggested low dose aspirin is more beneficial for people <70 kg and high dose aspirin is more beneficial for those ≥70 kg. However, more recent trials have suggested lower dose aspirin is not more efficacious in people with a low body weight and more evidence is required to determine the effect of higher dose aspirin in people with a high body weight. The United States Preventive Services Task Force (USPSTF), , recommended initiating low-dose aspirin use for the primary prevention of cardiovascular disease and colon cancer in adults aged 50 to 59 years who have a 10% or greater 10-year cardiovascular disease (CVD) risk, are not at increased risk for bleeding, have a life expectancy of at least 10 years, and are willing to take low-dose aspirin daily for at least 10 years. However, in 2021, the USPSTF recommended against the routine use of daily aspirin for primary prevention in adults in their 40s and 50s, citing the fact that the risk of side effects outweighs the potential benefits. Individuals under 60 should first consult a healthcare provider before initiating daily aspirin. In those with no previous history of heart disease, aspirin decreases the risk of a non-fatal myocardial infarction but increases the risk of bleeding and does not change the overall risk of death. Specifically over 5 years it decreased the risk of a cardiovascular event by 1 in 265 and increased the risk of bleeding by 1 in 210. Aspirin appears to offer little benefit to those at lower risk of heart attack or stroke—for instance, those without a history of these events or with pre-existing disease. Some studies recommend aspirin on a case-by-case basis, while others have suggested the risks of other events, such as gastrointestinal bleeding, were enough to outweigh any potential benefit, and recommended against using aspirin for primary prevention entirely. Aspirin has also been suggested as a component of a polypill for prevention of cardiovascular disease.
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1525_13
Complicating the use of aspirin for prevention is the phenomenon of aspirin resistance. For people who are resistant, aspirin's efficacy is reduced. Some authors have suggested testing regimens to identify people who are resistant to aspirin. After percutaneous coronary interventions (PCIs), such as the placement of a coronary artery stent, a U.S. Agency for Healthcare Research and Quality guideline recommends that aspirin be taken indefinitely. Frequently, aspirin is combined with an ADP receptor inhibitor, such as clopidogrel, prasugrel, or ticagrelor to prevent blood clots. This is called dual antiplatelet therapy (DAPT). Duration of DAPT was advised in the United States and European Union guidelines after the CURE and PRODIGY studies . In 2020, the systematic review and network meta-analysis from Khan et al. showed promising benefits of short-term (< 6 months) DAPT followed by P2Y12 inhibitors in selected patients, as well as the benefits of extended-term (> 12 months) DAPT in high risk patients. In conclusion, the optimal duration of DAPT after PCIs should be personalized after outweighing each patient's risks of ischemic events and risks of bleeding events with consideration of multiple patient-related and procedure-related factors. Moreover, aspirin should be continued indefinitely after DAPT is complete. Cancer prevention Aspirin may reduce the overall risk of both getting cancer and dying from cancer. There is substantial evidence for lowering the risk of colorectal cancer (CRC), but must be taken for at least 10–20 years to see this benefit. It may also slightly reduce the risk of endometrial cancer, breast cancer, and prostate cancer.
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1525_14
Some conclude the benefits are greater than the risks due to bleeding in those at average risk. Others are unclear if the benefits are greater than the risk. Given this uncertainty, the 2007 United States Preventive Services Task Force (USPSTF) guidelines on this topic recommended against the use of aspirin for prevention of CRC in people with average risk. Nine years later however, the USPSTF issued a grade B recommendation for the use of low-dose aspirin (75 to 100mg/day) "for the primary prevention of CVD [cardiovascular disease] and CRC in adults 50 to 59 years of age who have a 10% or greater 10-year CVD risk, are not at increased risk for bleeding, have a life expectancy of at least 10 years, and are willing to take low-dose aspirin daily for at least 10 years". A meta-analysis through 2019 said that there was an association between taking aspirin and lower risk of cancer of the colorectum, esophagus, and stomach. In 2021, the U.S. Preventive services Task Force raised questions about the use of aspirin in cancer prevention. It notes the results of the 2018 ASPREE (Aspirin in Reducing Events in the Elderly) Trial, in which the risk of cancer-related death was higher in the aspirin-treated group than in the placebo group. Psychiatry Bipolar disorder Aspirin, along with several other agents with anti-inflammatory properties, has been repurposed as an add-on treatment for depressive episodes in subjects with bipolar disorder in light of the possible role of inflammation in the pathogenesis of severe mental disorders. However, meta-analytic evidence is based on very few studies and does not suggest any efficacy of aspirin in the treatment of bipolar depression. Thus, notwithstanding the biological rationale, the clinical perspectives of aspirin and anti-inflammatory agents in the treatment of bipolar depression remain uncertain. Dementia There is no evidence that aspirin prevents dementia.
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1525_15
Dementia There is no evidence that aspirin prevents dementia. Other uses Aspirin is a first-line treatment for the fever and joint-pain symptoms of acute rheumatic fever. The therapy often lasts for one to two weeks, and is rarely indicated for longer periods. After fever and pain have subsided, the aspirin is no longer necessary, since it does not decrease the incidence of heart complications and residual rheumatic heart disease. Naproxen has been shown to be as effective as aspirin and less toxic, but due to the limited clinical experience, naproxen is recommended only as a second-line treatment. Along with rheumatic fever, Kawasaki disease remains one of the few indications for aspirin use in children in spite of a lack of high quality evidence for its effectiveness. Low-dose aspirin supplementation has moderate benefits when used for prevention of pre-eclampsia. This benefit is greater when started in early pregnancy. Resistance For some people, aspirin does not have as strong an effect on platelets as for others, an effect known as aspirin-resistance or insensitivity. One study has suggested women are more likely to be resistant than men, and a different, aggregate study of 2,930 people found 28% were resistant. A study in 100 Italian people found, of the apparent 31% aspirin-resistant subjects, only 5% were truly resistant, and the others were noncompliant. Another study of 400 healthy volunteers found no subjects who were truly resistant, but some had "pseudoresistance, reflecting delayed and reduced drug absorption".
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1525_16
Meta-analysis and systematic reviews have concluded that laboratory confirmed aspirin resistance confers increased rates of poorer outcomes in cardiovascular and neurovascular diseases. Although the majority of research conducted has surrounded cardiovascular and neurovascular, there is emerging research into the risk of aspirin resistance after orthopaedic surgery where aspirin is used for venous thromboembolism prophylaxis. Aspirin resistance in orthopaedic surgery, specifically after total hip and knee arthroplasties, is of interest as risk factors for aspirin resistance are also risk factors for venous thromboembolisms and osteoarthritis; the sequalae of requiring a total hip or knee arthroplasty. Some of these risk factors include obesity, advancing age, diabetes mellitus, dyslipidaemia and inflammatory diseases. However, unlike cardiovascular and neurovascular diseases, there is no confirmation on the incidence rates of aspirin resistance in orthopaedic surgery, nor is there confirmation on the clinical implications. Veterinary medicine Aspirin is sometimes used in veterinary medicine as an anticoagulant or to relieve pain associated with musculoskeletal inflammation or osteoarthritis. Aspirin should only be given to animals under the direct supervision of a veterinarian, as adverse effects—including gastrointestinal issues—are common. An aspirin overdose in any species may result in salicylate poisoning, characterized by hemorrhaging, seizures, coma, and even death. Dogs are better able to tolerate aspirin than cats are. Cats metabolize aspirin slowly because they lack the glucuronide conjugates that aid in the excretion of aspirin, making it potentially toxic if dosing is not spaced out properly. No clinical signs of toxicosis occurred when cats were given 25mg/kg of aspirin every 48 hours for 4 weeks, but the recommended dose for relief of pain and fever and for treating blood clotting diseases in cats is 10mg/kg every 48 hours to allow for metabolization. Dosages
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1525_17
Dosages Adult aspirin tablets are produced in standardised sizes, which vary slightly from country to country, for example 300mg in Britain and 325mg (or 5 grains) in the United States. Smaller doses are based on these standards, e.g., 75mg and 81mg tablets. The tablets are commonly called "baby aspirin" or "baby-strength", because they were originallybut no longerintended to be administered to infants and children. No medical significance occurs due to the slight difference in dosage between the 75mg and the 81mg tablets. The dose required for benefit appears to depend on a person's weight. For those weighing less than , low dose is effective for preventing cardiovascular disease; for patients above this weight, higher doses are required. In general, for adults, doses are taken four times a day for fever or arthritis, with doses near the maximal daily dose used historically for the treatment of rheumatic fever. For the prevention of myocardial infarction (MI) in someone with documented or suspected coronary artery disease, much lower doses are taken once daily. March 2009 recommendations from the USPSTF on the use of aspirin for the primary prevention of coronary heart disease encourage men aged 45–79 and women aged 55–79 to use aspirin when the potential benefit of a reduction in MI for men or stroke for women outweighs the potential harm of an increase in gastrointestinal hemorrhage. The WHI study said regular low dose (75 or 81mg) aspirin female users had a 25% lower risk of death from cardiovascular disease and a 14% lower risk of death from any cause. Low-dose aspirin use was also associated with a trend toward lower risk of cardiovascular events, and lower aspirin doses (75 or 81mg/day) may optimize efficacy and safety for people requiring aspirin for long-term prevention. In children with Kawasaki disease, aspirin is taken at dosages based on body weight, initially four times a day for up to two weeks and then at a lower dose once daily for a further six to eight weeks.
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1525_18
Adverse effects In October 2020, the U.S. Food and Drug Administration (FDA) required the drug label to be updated for all nonsteroidal anti-inflammatory medications to describe the risk of kidney problems in unborn babies that result in low amniotic fluid. They recommend avoiding NSAIDs in pregnant women at 20 weeks or later in pregnancy. One exception to the recommendation is the use of low-dose 81 mg aspirin at any point in pregnancy under the direction of a health care professional. Contraindications Aspirin should not be taken by people who are allergic to ibuprofen or naproxen, or who have salicylate intolerance or a more generalized drug intolerance to NSAIDs, and caution should be exercised in those with asthma or NSAID-precipitated bronchospasm. Owing to its effect on the stomach lining, manufacturers recommend people with peptic ulcers, mild diabetes, or gastritis seek medical advice before using aspirin. Even if none of these conditions is present, the risk of stomach bleeding is still increased when aspirin is taken with alcohol or warfarin. People with hemophilia or other bleeding tendencies should not take aspirin or other salicylates. Aspirin is known to cause hemolytic anemia in people who have the genetic disease glucose-6-phosphate dehydrogenase deficiency, particularly in large doses and depending on the severity of the disease. Use of aspirin during dengue fever is not recommended owing to increased bleeding tendency. People with kidney disease, hyperuricemia, or gout should not take aspirin because it inhibits the kidneys' ability to excrete uric acid, thus may exacerbate these conditions. Aspirin should not be given to children or adolescents to control cold or influenza symptoms, as this has been linked with Reye's syndrome. Gastrointestinal
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1525_19
Gastrointestinal Aspirin use has been shown to increase the risk of gastrointestinal bleeding. Although some enteric-coated formulations of aspirin are advertised as being "gentle to the stomach", in one study, enteric coating did not seem to reduce this risk. Combining aspirin with other NSAIDs has also been shown to further increase this risk. Using aspirin in combination with clopidogrel or warfarin also increases the risk of upper gastrointestinal bleeding. Blockade of COX-1 by aspirin apparently results in the upregulation of COX-2 as part of a gastric defense. Several trials suggest that the simultaneous use of a COX-2 inhibitor with aspirin may increase the risk of gastrointestinal injury. However, currently available evidence has been unable to prove that this effect is consistently repeatable in everyday clinical practice. More dedicated research is required to provide greater clarity on the subject. Therefore, caution should be exercised if combining aspirin with any "natural" supplements with COX-2-inhibiting properties, such as garlic extracts, curcumin, bilberry, pine bark, ginkgo, fish oil, resveratrol, genistein, quercetin, resorcinol, and others. In addition to enteric coating, "buffering" is the other main method companies have used to try to mitigate the problem of gastrointestinal bleeding. Buffering agents are intended to work by preventing the aspirin from concentrating in the walls of the stomach, although the benefits of buffered aspirin are disputed. Almost any buffering agent used in antacids can be used; Bufferin, for example, uses magnesium oxide. Other preparations use calcium carbonate. Gas-forming agents in effervescent tablet and powder formulations can also double as a buffering agent, one example being sodium bicarbonate found in Alka-Seltzer. Taking it with vitamin C has been investigated as a method of protecting the stomach lining. Taking equal doses of vitamin C and aspirin may decrease the amount of stomach damage that occurs compared to taking aspirin alone.
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1525_20
Retinal vein occlusion It is a widespread habit among eye specialists (ophthalmologists) to prescribe aspirin as an add-on medication for patients with retinal vein occlusion (RVO), such as central retinal vein occlusion (CRVO) and branch retinal vein occlusion (BRVO). The reason of this widespread use is the evidence of its proven effectiveness in major systemic venous thrombotic disorders, and it has been assumed that may be similarly beneficial in various types of retinal vein occlusion. However, a large-scale investigation based on data of nearly 700 patients showed "that aspirin or other antiplatelet aggregating agents or anticoagulants adversely influence the visual outcome in patients with CRVO and hemi-CRVO, without any evidence of protective or beneficial effect". Several expert groups, including the Royal College of Ophthalmologists, recommended against the use of antithrombotic drugs (incl. aspirin) for patients with RVO. Central effects Large doses of salicylate, a metabolite of aspirin, cause temporary tinnitus (ringing in the ears) based on experiments in rats, via the action on arachidonic acid and NMDA receptors cascade. Reye's syndrome
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1525_21
Reye's syndrome Reye's syndrome, a rare but severe illness characterized by acute encephalopathy and fatty liver, can occur when children or adolescents are given aspirin for a fever or other illness or infection. From 1981 to 1997, 1207 cases of Reye's syndrome in people younger than 18 were reported to the U.S. Centers for Disease Control and Prevention. Of these, 93% reported being ill in the three weeks preceding the onset of Reye's syndrome, most commonly with a respiratory infection, chickenpox, or diarrhea. Salicylates were detectable in 81.9% of children for whom test results were reported. After the association between Reye's syndrome and aspirin was reported, and safety measures to prevent it (including a Surgeon General's warning, and changes to the labeling of aspirin-containing drugs) were implemented, aspirin taken by children declined considerably in the United States, as did the number of reported cases of Reye's syndrome; a similar decline was found in the United Kingdom after warnings against pediatric aspirin use were issued. The U.S. Food and Drug Administration now recommends aspirin (or aspirin-containing products) should not be given to anyone under the age of 12 who has a fever, and the UK National Health Service recommends children who are under 16 years of age should not take aspirin, unless it is on the advice of a doctor. Skin For a small number of people, taking aspirin can result in symptoms including hives, swelling, and headache. Aspirin can exacerbate symptoms among those with chronic hives, or create acute symptoms of hives. These responses can be due to allergic reactions to aspirin, or more often due to its effect of inhibiting the COX-1 enzyme. Skin reactions may also tie to systemic contraindications, seen with NSAID-precipitated bronchospasm, or those with atopy.
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1525_22
Aspirin and other NSAIDs, such as ibuprofen, may delay the healing of skin wounds. Earlier findings from two small, low-quality trials suggested a benefit with aspirin (alongside compression therapy) on venous leg ulcer healing time and leg ulcer size, however larger, more recent studies of higher quality have been unable to corroborate these outcomes. As such, further research is required to clarify the role of aspirin in this context. Other adverse effects Aspirin can induce swelling of skin tissues in some people. In one study, angioedema appeared one to six hours after ingesting aspirin in some of the people. However, when the aspirin was taken alone, it did not cause angioedema in these people; the aspirin had been taken in combination with another NSAID-induced drug when angioedema appeared. Aspirin causes an increased risk of cerebral microbleeds having the appearance on MRI scans of 5 to 10mm or smaller, hypointense (dark holes) patches. Such cerebral microbleeds are important, since they often occur prior to ischemic stroke or intracerebral hemorrhage, Binswanger disease, and Alzheimer's disease. A study of a group with a mean dosage of aspirin of 270mg per day estimated an average absolute risk increase in intracerebral hemorrhage (ICH) of 12 events per 10,000 persons. In comparison, the estimated absolute risk reduction in myocardial infarction was 137 events per 10,000 persons, and a reduction of 39 events per 10,000 persons in ischemic stroke. In cases where ICH already has occurred, aspirin use results in higher mortality, with a dose of about 250mg per day resulting in a relative risk of death within three months after the ICH around 2.5 (95% confidence interval 1.3 to 4.6). Aspirin and other NSAIDs can cause abnormally high blood levels of potassium by inducing a hyporeninemic hypoaldosteronic state via inhibition of prostaglandin synthesis; however, these agents do not typically cause hyperkalemia by themselves in the setting of normal renal function and euvolemic state.
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1525_23
Aspirin can cause prolonged bleeding after operations for up to 10 days. In one study, 30 of 6499 people having elective surgery required reoperations to control bleeding. Twenty had diffuse bleeding and 10 had bleeding from a site. Diffuse, but not discrete, bleeding was associated with the preoperative use of aspirin alone or in combination with other NSAIDS in 19 of the 20 diffuse bleeding people. On 9 July 2015, the FDA toughened warnings of increased heart attack and stroke risk associated with nonsteroidal anti-inflammatory drugs (NSAID). Aspirin is an NSAID but is not affected by the new warnings. Overdose Aspirin overdose can be acute or chronic. In acute poisoning, a single large dose is taken; in chronic poisoning, higher than normal doses are taken over a period of time. Acute overdose has a mortality rate of 2%. Chronic overdose is more commonly lethal, with a mortality rate of 25%; chronic overdose may be especially severe in children. Toxicity is managed with a number of potential treatments, including activated charcoal, intravenous dextrose and normal saline, sodium bicarbonate, and dialysis. The diagnosis of poisoning usually involves measurement of plasma salicylate, the active metabolite of aspirin, by automated spectrophotometric methods. Plasma salicylate levels in general range from 30 to 100mg/l after usual therapeutic doses, 50–300mg/l in people taking high doses and 700–1400mg/l following acute overdose. Salicylate is also produced as a result of exposure to bismuth subsalicylate, methyl salicylate, and sodium salicylate.
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1525_24
Interactions Aspirin is known to interact with other drugs. For example, acetazolamide and ammonium chloride are known to enhance the intoxicating effect of salicylates, and alcohol also increases the gastrointestinal bleeding associated with these types of drugs. Aspirin is known to displace a number of drugs from protein-binding sites in the blood, including the antidiabetic drugs tolbutamide and chlorpropamide, warfarin, methotrexate, phenytoin, probenecid, valproic acid (as well as interfering with beta oxidation, an important part of valproate metabolism), and other NSAIDs. Corticosteroids may also reduce the concentration of aspirin. Other NSAIDs, such as ibuprofen and naproxen, may reduce the antiplatelet effect of aspirin. Although limited evidence suggests this may not result in a reduced cardioprotective effect of aspirin. The pharmacological activity of spironolactone may be reduced by taking aspirin, and it is known to compete with penicillin G for renal tubular secretion. Aspirin may also inhibit the absorption of vitamin C. Research Psychiatry In psychiatric research, aspirin has been investigated as an add-on treatment for different disorders in the context of drug repurposing strategies, considering the role of inflammation in the pathogenesis of severe mental illnesses. Bipolar disorder Aspirin has been repurposed as an add-on treatment for depressive episodes in subjects with bipolar disorder. However, meta-analytic evidence is based on very few studies and does not suggest any efficacy of aspirin in the treatment of bipolar depression. Thus, notwithstanding the biological rationale, the clinical perspectives of aspirin and anti-inflammatory agents in the treatment of bipolar depression remain uncertain.
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1525_25
Infectious diseases Several studies investigated the anti-infective properties of aspirin for bacterial, viral and parasitic infections. Aspirin was demonstrated to limit platelet activation induced by Staphylococcus aureus and Enterococcus faecalis and to reduce streptococcal adhesion to heart valves. In patients with tuberculous meningitis, the addition of aspirin reduced the risk of new cerebral infarction [RR = 0.52 (0.29-0.92)]. A role of aspirin on bacterial and fungal biofilm is also being supported by growing evidence. Cancer prevention Aspirin might weakly reduce the risk of breast cancer per a 2020 meta-analysis. See also List of drugs: As–Az References Further reading McTavish, Jan R. (Fall 1987). "What's in a name? Aspirin and the American Medical Association". Bulletin of the History of Medicine. 61.3: 343–366. . On loss of patent in the USA in 1917. External links 1897 in Germany 1897 in science Acetate esters Acetylsalicylic acids Antiplatelet drugs Bayer brands Brands that became generic Chemical substances for emergency medicine Commercialization of traditional medicines Covalent inhibitors Equine medications German inventions Hepatotoxins Nonsteroidal anti-inflammatory drugs Salicylic acids Salicylyl esters World Health Organization essential medicines Wikipedia medicine articles ready to translate
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1526_0
In the Hebrew Bible, Abner ( ) was the cousin of King Saul and the commander-in-chief of his army. His name also appears as "Abiner son of Ner", where the longer form Abiner means "my father is Ner". Biblical narrative Abner is initially mentioned incidentally in Saul's history, first appearing as the son of Ner, Saul's uncle, and the commander of Saul's army. He then comes to the story again as the commander who introduced David to Saul following David's killing of Goliath. He is not mentioned in the account of the disastrous battle of Gilboa when Saul's power was crushed. Seizing the youngest but only surviving of Saul's sons, Ish-bosheth, also called Eshbaal, Abner set him up as king over Israel at Mahanaim, east of the Jordan. David, who was accepted as king by Judah alone, was meanwhile reigning at Hebron, and for some time war was carried on between the two parties.
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1526_1
The only engagement between the rival factions which is told at length is noteworthy, inasmuch as it was preceded by an encounter at Gibeon between twelve chosen men from each side, in which the whole twenty-four seem to have perished. In the general engagement which followed, Abner was defeated and put to flight. He was closely pursued by Asahel, brother of Joab, who is said to have been "light of foot as a wild roe". As Asahel would not desist from the pursuit, though warned, Abner was compelled to slay him in self-defence. This originated a deadly feud between the leaders of the opposite parties, for Joab, as next of kin to Asahel, was by the law and custom of the country the avenger of his blood. However, according to Josephus, in Antiquities, Book 7, Chapter 1, Joab had forgiven Abner for the death of his brother, Asahel, the reason being that Abner had slain Asahel honorably in combat after he had first warned Asahel and tried to knock the wind out of him with the butt of his spear. However, probably by intervention of God, it went through Asahel. The Bible says everyone stopped and looked. That shows that something like this never happened before. This battle was part of a civil war between David and Ish-bosheth, the son of Saul. After this battle Abner switched to the side of David and granted him control over the tribe of Benjamin. This act put Abner in David's favor. For some time afterward the war was carried on, the advantage being invariably on the side of David. At length, Ish-bosheth lost the main prop of his tottering cause by accusing Abner of sleeping with Rizpah, one of Saul's concubines, an alliance which, according to contemporary notions, would imply pretensions to the throne.
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1526_2
Abner was indignant at the rebuke, and immediately opened negotiations with David, who welcomed him on the condition that his wife Michal should be restored to him. This was done, and the proceedings were ratified by a feast. Almost immediately after, however, Joab, who had been sent away, perhaps intentionally returned and slew Abner at the gate of Hebron. The ostensible motive for the assassination was a desire to avenge Asahel, and this would be a sufficient justification for the deed according to the moral standard of the time (although Abner should have been safe from such a revenge killing in Hebron, which was a City of Refuge). The conduct of David after the event was such as to show that he had no complicity in the act, though he could not venture to punish its perpetrators. David had Abner buried in Hebron, as it states in Samuel 3:31-32, "And David said to all the people who were with him, 'Rend your clothes and gird yourselves with sackcloth, and wail before Abner.' And King David went after the bier. And they buried Abner in Hebron, and the king raised his voice and wept on Abner's grave, and all the people wept." Shortly after Abner's death, Ish-bosheth was assassinated as he slept, and David became king of the reunited kingdoms.
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1526_3
Rabbinical Literature Son of the Witch of En-dor (Pirḳe R. El. xxxiii.), and the hero par excellence in the Haggadah (Yalḳ., Jer. 285; Eccl. R. on ix. 11; Ḳid. 49b). Conscious of his extraordinary strength, he exclaimed: "If I could only catch hold of the earth, I could shake it" (Yalḳ. l.c.)—a saying which parallels the famous utterance of Archimedes, "Had I a fulcrum, I could move the world." According to the Midrash (Eccl. R. l.c.) it would have been easier to move a wall six yards thick than one of the feet of Abner, who could hold the Israelitish army between his knees. Yet when his time came (), Joab smote him. But even in his dying hour, Abner seized his foe like a ball of thread, threatening to crush him. Then the Israelites came and pleaded for Joab's life, saying: "If thou killest him we shall be orphaned, and our women and all our belongings will become a prey to the Philistines." Abner answered: "What can I do? He has extinguished my light" (has wounded me fatally). The Israelites replied: "Entrust thy cause to the true judge [God]." Then Abner released his hold upon Joab and fell dead to the ground (Yalḳ. l.c.).
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1526_4
His One Sin. The rabbis agree that Abner deserved this violent death, though opinions differ concerning the exact nature of the sin that entailed so dire a punishment on one who was, on the whole, considered a "righteous man" (Gen. R. lxxxii. 4). Some reproach him that he did not use his influence with Saul to prevent him from murdering the priests of Nob (Yer. Peah, i. 16a; Lev. R. xxvi. 2; Sanh. 20a)—convinced as he was of the innocence of the priests and of the propriety of their conduct toward David, Abner holding that as leader of the army David was privileged to avail himself of the Urim and Thummim (I Sam. xxii. 9–19). Instead of contenting himself with passive resistance to Saul's command to murder the priests (Yalḳ., Sam. 131), Abner ought to have tried to restrain the king. Others maintain that Abner did make such an attempt, but in vain, and that his one sin consisted in that he delayed the beginning of David's reign over Israel by fighting him after Saul's death for two years and a half (Sanh. l.c.). Others, again, while excusing him for this—in view of a tradition founded on Gen. xlix. 27, according to which there were to be two kings of the house of Benjamin—blame Abner for having prevented a reconciliation between Saul and David on the occasion when the latter, in holding up the skirt of Saul's robe (I Sam. xxiv. 11), showed how unfounded was the king's mistrust of him. Saul was inclined to be pacified; but Abner, representing to him that David might have found the piece of the garment anywhere—possibly caught on a thorn—prevented the reconciliation (Yer. Peah, l.c., Lev. R. l.c., and elsewhere). Moreover, it was wrong in Abner to permit Israelitish youths to kill one another for sport (II Sam. ii. 14–16). No reproach, however, attaches to him for the death of Asahel, since Abner killed him in self-defense (Sanh. 49a).
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1526_5
It is characteristic of the rabbinical view of the Bible narratives that Abner, the warrior pure and simple, is styled "Lion of the Law" (Yer. Peah, l.c.), and that even a specimen is given of a halakic discussion between him and Doeg as to whether the law in Deut. xxiii. 3 excluded Ammonite and Moabite women from the Jewish community as well as men. Doeg was of the opinion that David, being descended from the Moabitess Ruth, was not fit to wear the crown, nor even to be considered a true Israelite; while Abner maintained that the law affected only the male line of descent. When Doeg's dialectics proved more than a match for those of Abner, the latter went to the prophet Samuel, who not only supported Abner in his view, but utterly refuted Doeg's assertions (Midr. Sam. xxii.; Yeb. 76b et seq.). One of the most prominent families (Ẓiẓit ha-Kesat) in Jerusalem in the middle of the first century of the common era claimed descent from Abner (Gen. R. xcviii.). Tomb of Abner The site known as the Tomb of Abner is located not far from the Cave of the Patriarchs in Hebron and receives visitors throughout the year. Many travelers have recorded visiting the tomb over the centuries. Benjamin of Tudela, who began his journeys in 1165, wrote in the journal, "The valley of Eshkhol is north of the mountain upon which Hebron stood, and the cave of Makhpela is east thereof. A bow-shot west of the cave is the sepulchre of Abner the son of Ner." A rabbi in the 12th century records visiting the tomb as reprinted in Elkan Nathan Adler's book Jewish Travellers in the Middle Ages: 19 Firsthand Accounts. The account states, "I, Jacob, the son of R. Nathaniel ha Cohen, journeyed with much difficulty, but God helped me to enter the Holy Land, and I saw the graves of our righteous Patriarchs in Hebron and the grave of Abner the son of Ner." Adler postulates that the visit must have occurred prior to Saladin's capture of Jerusalem in 1187.
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1526_6
Rabbi Moses Basola records visiting the tomb in 1522. He states, "Abner's grave is in the middle of Hebron; the Muslims built a mosque over it." Another visitor in the 1500s states that "at the entrance to the market in Hebron, at the top of the hill against the wall, Abner ben Ner is buried, in a church, in a cave." This visit was recorded in Sefer Yihus ha-Tzaddiqim (Book of Genealogy of the Righteous), a collection of travelogues from 1561. Abraham Moshe Lunz reprinted the book in 1896. Menahem Mendel of Kamenitz, considered the first hotelier in the Land of Israel, wrote about the Tomb of Abner is his 1839 book Korot Ha-Itim, which was translated into English as The Book of the Occurrences of the Times to Jeshurun in the Land of Israel. He states, "Here I write of the graves of the righteous to which I paid my respects. Hebron – Described above is the character and order of behavior of those coming to pray at the Cave of ha-Machpelah. I went there, between the stores, over the grave of Avner ben Ner and was required to pay a Yishmaeli – the grave was in his courtyard – to allow me to enter." The author and traveler J. J. Benjamin mentioned visiting the tomb in his book Eight Years in Asia and Africa (1859, Hanover). He states, "On leaving the Sepulchre of the Patriarchs, and proceeding on the road leading to the Jewish quarter, to the left of the courtyard, is seen a Turkish dwelling house, by the side of which is a small grotto, to which there is a descent of several steps. This is the tomb of Abner, captain of King Saul. It is held in much esteem by the Arabs, and the proprietor of it takes care that it is always kept in the best order. He requires from those who visit it a small gratuity."
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1526_7
The British scholar Israel Abrahams wrote in his 1912 book The Book of Delight and Other Papers, "Hebron was the seat of David's rule over Judea. Abner was slain here by Joab, and was buried here – they still show Abner's tomb in the garden of a large house within the city. By the pool at Hebron were slain the murderers of Ishbosheth..." Over the years the tomb fell into disrepair and neglect. It was closed to the public in 1994. In 1996, a group of 12 Israeli women filed a petition with the Supreme Court requesting the government to reopen the Tomb of Abner. More requests were made over the years <ref>{{Cite web|title = Articles by David Wilder: The Mystery of the Tomb of Avner ben Ner or Understanding Uzis Whims|url = http://davidwilder.blogspot.co.il/1997/05/mystery-of-tomb-of-avner-ben-ner-or.html|website = davidwilder.blogspot.co.il|access-date = 2016-01-06}}</ref> and eventually arrangements were made to have the site open to the general public on ten days throughout the year corresponding to the ten days that the Isaac Hall of the Cave of the Patriarchs is open. In early 2007 new mezuzot were affixed to the entrance of the site.
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1526_8
In popular culture 1960, David and Goliath (film) – Abner is portrayed by Massimo Serato. In this version, Abner tries to murder David (Ivica Pajer) when he returns in triumph after killing Goliath. However, here Abner is slain by King Saul (Orson Welles). 1961, A Story of David (film) – Abner is portrayed by Welsh actor David Davies. 1976, The Story of David (television series) – Younger version of Abner is portrayed by Israeli actor Yehuda Efroni. Older version of Abner is portrayed by British actor Brian Blessed. 1985, King David (film) – Abner is portrayed by English actor John Castle. King David portrayed by Richard Gere. 1997, King David (musical) – written by Tim Rice and Alan Menken. Abner is portrayed by American actor Timothy Shew. 1997, David (television drama) – Abner is portrayed by Richard Ashcroft. 2009, Kings (television series) – Abner portrayed by Wes Studi as General Linus Abner. The series is set in a multi-ethnic Western culture similar to that in the present-day United States, but with characters drawn from the Bible. 2012, Rei Davi (Brazilian television series) – Abner is portrayed by Iran Malfitano. Notes References Citations Cited sources External links Pictures of Avner ben Ner's Tomb in Hebron Tomb of Abner page on Hebron.com website. David, Abraham (ed.) (1999). In Zion and Jerusalem: The Itinerary of Rabbi Moses Basola (1521–1523) C. G. Foundation Jerusalem Project Publications of the Martin (Szusz) Department of Land of Israel Studies of Bar-Ilan University . Reference is made to visiting the tomb of Abner. (p. 77). Photo of prayer at the Tomb of Abner from Imagekind. Photo of prayer at the Tomb of Abner from PicJew. Photos of Tomb of Abner Ben Ner from the book Sites in Hebron'' by David Wilder. ASIN: B00ALHB89Y. Biblical murder victims Male murder victims Warriors of Asia Kingdom of Israel (united monarchy) House of Saul ca:Llista de personatges bíblics#Abner
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1527_0
Ahmed I ( ; ; April 1590 – 22 November 1617) was the Sultan of the Ottoman Empire from 1603 until his death in 1617. Ahmed's reign is noteworthy for marking the first breach in the Ottoman tradition of royal fratricide; henceforth Ottoman rulers would no longer systematically execute their brothers upon accession to the throne. He is also well known for his construction of the Blue Mosque, one of the most famous mosques in Turkey. Early life Ahmed was probably born in April 1590 at the Manisa Palace, Manisa, when his father Şehzade Mehmed was still a prince and the governor of the Sanjak of Manisa. His mother was Handan Sultan. After his grandfather Murad III's death in 1595, his father came to Constantinople and ascended the throne as Sultan Mehmed III. Mehmed ordered the execution of nineteen of his own brothers and half brothers. Ahmed's elder brother Şehzade Mahmud was also executed by his father Mehmed on 7 June 1603, just before Mehmed's own death on 22 December 1603. Mahmud was buried along with his mother in a separate mausoleum built by Ahmed in Şehzade Mosque, Constantinople. Reign Ahmed ascended the throne after his father's death in 1603, at the age of thirteen, when his powerful grandmother Safiye Sultan was still alive. A far lost uncle of Ahmed, Yahya, resented his accession to the throne and spent his life scheming to become Sultan. Ahmed broke with the traditional fratricide following previous enthronements and did not order the execution of his brother Mustafa. Instead Mustafa was sent to live at the old palace at Bayezit along with their grandmother Safiye Sultan. This was most likely due to Ahmed's young age - he had not yet demonstrated his ability to sire children, and Mustafa was then the only other candidate for the Ottoman throne. His brother's execution would have endangered the dynasty, and thus he was spared.
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1527_1
In the earlier part of his reign Ahmed I showed decision and vigor, which were belied by his subsequent conduct. The wars in Hungary and Persia, which attended his accession, terminated unfavourably for the empire. Its prestige was further tarnished in the Treaty of Zsitvatorok, signed in 1606, whereby the annual tribute paid by Austria was abolished. Following the crushing defeat in the Ottoman–Safavid War (1603–18) against the neighbouring rivals Safavid Empire, led by Shah Abbas the Great, Georgia, Azerbaijan and other vast territories in the Caucasus were ceded back to Persia per the Treaty of Nasuh Pasha in 1612, territories that had been temporarily conquered in the Ottoman–Safavid War (1578–90). The new borders were drawn per the same line as confirmed in the Peace of Amasya of 1555. Ottoman-Safavid War: 1604–06 The Ottoman–Safavid War had begun shortly before the death of Ahmed's father Mehmed III. Upon ascending the throne, Ahmed I appointed Cigalazade Yusuf Sinan Pasha as the commander of the eastern army. The army marched from Constantinople on 15 June 1604, which was too late, and by the time it had arrived on the eastern front on 8 November 1604, the Safavid army had captured Yerevan and entered the Kars Eyalet, and could only be stopped in Akhaltsikhe. Despite the conditions being favourable, Sinan Pasha decided to stay for the winter in Van, but then marched to Erzurum to stop an incoming Safavid attack. This caused unrest within the army and the year was practically wasted for the Ottomans. In 1605, Sinan Pasha marched to take Tabriz, but the army was undermined by Köse Sefer Pasha, the Beylerbey of Erzurum, marching independently from Sinan Pasha and consequently being taken prisoner by the Safavids. The Ottoman army was routed at Urmia and had to flee firstly to Van and then to Diyarbekir. Here, Sinan Pasha sparked a rebellion by executing the Beylerbey of Aleppo, Canbulatoğlu Hüseyin Pasha, who had come to provide help, upon the pretext that he had arrived too late. He soon died himself and the Safavid army was able to capture Ganja, Shirvan and Shamakhi in Azerbaijan.
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1527_2
War with the Habsburgs: 1604–06 The Long Turkish War between the Ottomans and the Habsburg Monarchy had been going on for over a decade by the time Ahmed ascended the throne. Grand Vizier Malkoç Ali Pasha marched to the western front from Constantinople on 3 June 1604 and arrived in Belgrade, but died there, so Sokolluzade Lala Mehmed Pasha was appointed as the Grand Vizier and the commander of the western army. Under Mehmed Pasha, the western army recaptured Pest and Vác, but failed to capture Esztergom as the siege was lifted due to unfavourable weather and the objections of the soldiers. Meanwhile, the Prince of Transylvania, Stephen Bocskay, who struggled for the region's independence and had formerly supported the Habsburgs, sent a messenger to the Porte asking for help. Upon the promise of help, his forces also joined the Ottoman forces in Belgrade. With this help, the Ottoman army besieged Esztergom and captured it on 4 November 1605. Bocskai, with Ottoman help, captured Nové Zámky (Uyvar) and forces under Tiryaki Hasan Pasha took Veszprém and Palota. Sarhoş İbrahim Pasha, the Beylerbey of Nagykanizsa (Kanije), attacked the Austrian region of Istria. However, with Jelali revolts in Anatolia more dangerous than ever and a defeat in the eastern front, Mehmed Pasha was called to Constantinople. Mehmed Pasha suddenly died there, whilst preparing to leave for the east. Kuyucu Murad Pasha then negotiated the Peace of Zsitvatorok, which abolished the tribute of 30,000 ducats paid by Austria and addressed the Habsburg emperor as the equal of the Ottoman sultan. The Jelali revolts were a strong factor in the Ottomans' acceptance of the terms. This signaled the end of Ottoman growth in Europe.
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1527_3
Jelali revolts Resentment over the war with the Habsburgs and heavy taxation, along with the weakness of the Ottoman military response, combined to make the reign of Ahmed I the zenith of the Jelali revolts. Tavil Ahmed launched a revolt soon after the coronation of Ahmed I and defeated Nasuh Pasha and the Beylerbey of Anatolia, Kecdehan Ali Pasha. In 1605, Tavil Ahmed was offered the position of the Beylerbey of Shahrizor to stop his rebellion, but soon afterwards he went on to capture Harput. His son, Mehmed, obtained the governorship of Baghdad with a fake firman and defeated the forces of Nasuh Pasha sent to defeat him. Meanwhile, Canbulatoğlu Ali Pasha united his forces with the Druze Sheikh Ma'noğlu Fahreddin to defeat the Amir of Tripoli Seyfoğlu Yusuf. He went on to take control of the Adana area, forming an army and issuing coins. His forces routed the army of the newly appointed Beylerbey of Aleppo, Hüseyin Pasha. Grand Vizier Boşnak Dervish Mehmed Pasha was executed for the weakness he showed against the Jelalis. He was replaced by Kuyucu Murad Pasha, who marched to Syria with his forces to defeat the 30,000-strong rebel army with great difficulty, albeit with a decisive result, on 24 October 1607. Meanwhile, he pretended to forgive the rebels in Anatolia and appointed the rebel Kalenderoğlu, who was active in Manisa and Bursa, as the sanjakbey of Ankara. Baghdad was recaptured in 1607 as well. Canbulatoğlu Ali Pasha fled to Constantinople and asked for forgiveness from Ahmed I, who appointed him to Timișoara and later Belgrade, but then executed him due to his misrule there. Meanwhile, Kalenderoğlu was not allowed in the city by the people of Ankara and rebelled again, only to be crushed by Murad Pasha's forces. Kalenderoğlu ended up fleeing to Persia. Murad Pasha then suppressed some smaller revolts in Central Anatolia and suppressed other Jelali chiefs by inviting them to join the army.
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1527_4
Due to the widespread violence of the Jelali revolts, a great number of people had fled their villages and a lot of villages were destroyed. Some military chiefs had claimed these abandoned villages as their property. This deprived the Porte of tax income and on 30 September 1609, Ahmed I issued a letter guaranteeing the rights of the villagers. He then worked on the resettlement of abandoned villages. Ottoman-Safavid War: Peace and continuation The new Grand Vizier, Nasuh Pasha, did not want to fight with the Safavids. The Safavid Shah also sent a letter saying that he was willing to sign a peace treaty, with which he would have to send 200 loads of silk every year to Constantinople. On 20 November 1612, the Treaty of Nasuh Pasha was signed, which ceded all the lands the Ottoman Empire had gained in the war of 1578–90 back to Persia and reinstated the 1555 boundaries. However, the peace ended in 1615 when the Shah did not send the 200 loads of silk. On 22 May 1615, Grand Vizier Öküz Mehmed Pasha was assigned to organize an attack on Persia. Mehmed Pasha delayed the attack till the next year, until when the Safavids made their preparations and attacked Ganja. In April 1616, Mehmed Pasha left Aleppo with a large army and marched to Yerevan, where he failed to take the city and withdrew to Erzurum. He was removed from his post and replaced by Damat Halil Pasha. Halil Pasha went for the winter to Diyarbekir, while the Khan of Crimea, Canibek Giray, attacked the areas of Ganja, Nakhichevan and Julfa. Capitulations and trade treaties Ahmed I renewed trade treaties with England, France and Venice. In July 1612, the first ever trade treaty with the Dutch Republic was signed. He expanded the capitulations given to France, specifying that merchants from Spain, Ragusa, Genoa, Ancona and Florence could trade under the French flag. Architect and service to Islam
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1527_5
Architect and service to Islam Sultan Ahmed constructed the Sultan Ahmed Mosque, the magnum opus of the Ottoman architecture, across from the Hagia Sophia. The sultan attended the breaking of the ground with a golden pickaxe to begin the construction of the mosque complex. An incident nearly broke out after the sultan discovered that the Blue Mosque contained the same number of minarets as the grand mosque of Mecca. Ahmed became furious at this fault and became remorseful until the Shaykh-ul-Islam recommended that he should erect another minaret at the grand mosque of Mecca and the matter was solved. Ahmed became delightedly involved in the eleventh comprehensive renovations of the Kaaba, which had just been damaged by flooding. He sent craftsmen from Constantinople, and the golden rain gutter that kept rain from collecting on the roof of the Ka’ba was successfully renewed. It was again during the era of Sultan Ahmed that an iron web was placed inside the Zamzam Well in Mecca. The placement of this web about three feet below the water level was a response to lunatics who jumped into the well, imagining a promise of a heroic death. In Medina, the city of the Prophet Muhammad, a new pulpit made of white marble and shipped from Istanbul arrived in the mosque of the prophet and substituted the old, worn-out pulpit. It is also known that Sultan Ahmed erected two more mosques in Uskudar on the Asian side of Istanbul; however, neither of them has survived. The sultan had a crest carved with the footprint of Muhammad that he would wear on Fridays and festive days and illustrated one of the most significant examples of affection to the prophet in Ottoman history. Engraved inside the crest was a poem he composed: Character Sultan Ahmed was known for his skills in fencing, poetry, horseback riding, and fluency in several languages. Ahmed was a poet who wrote a number of political and lyrical works under the name Bahti. Ahmed patronized scholars, calligraphers, and pious men. Hence he commissioned a book entitled The Quintessence of Histories to be worked upon by calligraphers. He also attempted to enforce conformance to Islamic laws and traditions, restoring the old regulations that prohibited alcohol and he attempted to enforce attendance at Friday prayers and paying alms to the poor in the proper way. Death
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1527_6
Death Ahmed I died of typhus and gastric bleeding on 22 November 1617 at the Topkapı Palace, Istanbul. He was buried in Ahmed I Mausoleum, Sultan Ahmed Mosque. He was succeeded by his younger brother Şehzade Mustafa as Sultan Mustafa I. Later three of Ahmed's sons ascended to the throne: Osman II (r. 1618–22), Murad IV (r. 1623–40) and Ibrahim (r. 1640–48). Family Consorts Mahfiruz Hatun; Kösem Sultan;
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1527_7
Sons Sultan Osman II (3 November 1604, Constantinople, Topkapı Palace – murdered by janissaries and by Kara Davud Pasha, 20 May 1622, Constantinople, Topkapı Palace, buried in Ahmed I Mausoleum, Sultan Ahmed Mosque), with Mahfiruz, Sultan of the Ottoman Empire; Şehzade Mehmed (1605, Constantinople, Topkapı Palace – murdered by Osman II, 12 January 1621, Istanbul, Topkapı Palace, buried in Ahmed I Mausoleum, Sultan Ahmed Mosque) with Kösem; Sultan Murad IV (27 July 1612, Constantinople – 8 February 1640, Constantinople, Topkapı Palace, buried in Ahmed I Mausoleum, Sultan Ahmed Mosque), with Kösem, Sultan of the Ottoman Empire; Şehzade Bayezid (November 1612 – murdered by Murad IV, 27 July 1635, Constantinople, Topkapı Palace, buried in Ahmed I Mausoleum, Sultan Ahmed Mosque), with Mahfiruz; Şehzade Süleyman (1613, Istanbul – murdered by Murad IV, 27 July 1635, Constantinople, Topkapı Palace, buried in Ahmed I Mausoleum, Sultan Ahmed Mosque), with Kösem; Şehzade Selim (1613, Istanbul – murdered by Murad IV, 27 July 1635, Constantinople, Topkapı Palace, buried in Ahmed I Mausoleum, Sultan Ahmed Mosque), with Kösem; Şehzade Hüseyin (November 1614, Constantinople – after 1622, Constantinople, Topkapı Palace, buried in Mehmed III Mausoleum, Hagia Sophia Mosque); with Mahfiruz; Şehzade Kasım (1614, Constantinople – murdered by Murad IV, 17 February 1638, Constantinople, Topkapı Palace, buried in Murad III Mausoleum, Hagia Sophia Mosque), with Kösem; Sultan Ibrahim (5 November 1615, Constantinople – murdered by janissaries, 18 August 1648, Constantinople, Topkapı Palace, buried in Mustafa I Mausoleum, Hagia Sophia Mosque), with Kösem, Sultan of the Ottoman Empire.
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1527_8
Daughters Gevherhan Sultan (c. 1608 - 1660, buried in Ahmed I Mausoleum, Sultan Ahmed Mosque), with Kösem, Ayşe Sultan (1605/08 – 1657, Constantinople, buried in Ahmed I Mausoleum, Sultan Ahmed Mosque), with Kösem, Fatma Sultan (1607 – 1670, Constantinople, buried in Ahmed I Mausoleum, Sultan Ahmed Mosque), with Kösem; Hanzade Sultan (1607 – 23 September 1650, Constantinople, buried in Ibrahim I Mausoleum, Hagia Sophia Mosque), with Kösem; Atike Sultan (1613 – 1674, buried in Ibrahim I Mausoleum, Hagia Sophia Mosque). Abide Sultan (1618-1675), daughter of Fatma Sultan , married in 1642 to Koca Musa Pasha Legacy Today, Ahmed I is remembered mainly for the construction of the Sultan Ahmed Mosque (also known as the Blue Mosque), one of the masterpieces of Islamic architecture. The area in Fatih around the Mosque is today called Sultanahmet. He died at Topkapı Palace in Constantinople and is buried in a mausoleum right outside the walls of the famous mosque. In popular culture In the 2015 TV series Muhteşem Yüzyıl: Kösem, Ahmed I is portrayed by Turkish actor Ekin Koç. See also Transformation of the Ottoman Empire Abbas I's Kakhetian and Kartlian campaigns References External links [aged 27] 1590 births 1617 deaths Deaths from typhus Modern child rulers Ottoman people of the Ottoman–Persian Wars Infectious disease deaths in the Ottoman Empire 17th-century Ottoman sultans Turks of the Ottoman Empire Greeks of the Ottoman Empire People of the Ottoman Empire of Greek descent Ottoman dynasty
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1528_0
Ahmed II ( Aḥmed-i sānī) (25 February 1643 or 1 August 1642 – 6 February 1695) was the Sultan of the Ottoman Empire from 1691 to 1695. Early life Ahmed II was born on 25 February 1643 or 1 August 1642, the son of Sultan Ibrahim and Muazzez Sultan. On 21 October 1649, Ahmed along with his brothers Mehmed and Suleiman were circumcised. During the reigns of his older brothers, Ahmed was imprisoned in Kafes, and he stayed there almost 43 years. Reign During his reign, Sultan Ahmed II devoted most of his attention to the wars against the Habsburgs and related foreign policy, governmental and economic issues. Of these, the most important were the tax reforms and the introduction of the lifelong tax farm system (malikane) (see tax farming). Following the recovery of Belgrade under his predecessor, Suleiman II, the military frontier reached a rough stalemate on the Danube, with the Habsburgs no longer able to advance south of it, and the Ottomans attempting, ultimately unsuccessfully, to regain the initiative north of it. Among the most important features of Ahmed's reign was his reliance on Köprülüzade Fazıl Mustafa Pasha. Following his accession to the throne, Sultan Ahmed II confirmed Köprülüzade Fazıl Mustafa Pasha in his office as grand vizier. In office from 1689, Fazıl Mustafa Pasha was from the Köprülü family of grand viziers, and like most of his Köprülü predecessors in the same office, was an able administrator and military commander. Like his father Köprülü Mehmed Pasha (grand vizier 1656–61) before him, Fazıl Mustafa Pasha ordered the removal and execution of dozens of corrupt state officials of the previous regime and replaced them with men loyal to himself. He overhauled the tax system by adjusting it to the capabilities of the taxpayers affected by the latest wars. He also reformed troop mobilization and increased the pool of conscripts available for the army by drafting tribesmen in the Balkans and Anatolia. In October 1690, Fazıl Mustafa Pasha recaptured Belgrade, a key fortress that commanded the confluence of the rivers Danube and Sava; in Ottoman hands since 1521, the fortress had been conquered by the Habsburgs in 1688.
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1528_1
Fazıl Mustafa Pasha's victory at Belgrade was a major military achievement that gave the Ottomans hope that the military debacles of the 1680s—which had led to the loss of Hungary and Transylvania, an Ottoman vassal principality ruled by pro-Istanbul Hungarian princes— could be reversed. However, the Ottoman success proved ephemeral. On 19 August 1691, Fazıl Mustafa Pasha suffered a devastating defeat at the Battle of Slankamen at the hands of Ludwig Wilhelm von Baden, the Habsburg commander in chief in Hungary, nicknamed “Türkenlouis” (Louis the Turk) for his victories against the Ottomans. In the confrontation, recognized by contemporaries as “the bloodiest battle of the century,” the Ottomans suffered heavy losses: 20,000 men, including the grand vizier. With him, the sultan lost his most capable military commander and the last member of the Köprülü family, who for the previous half century had been instrumental in strengthening the Ottoman military. Under Fazıl Mustafa Pasha's successors, the Ottomans suffered further defeats. In June 1692 the Habsburgs conquered Várad (Oradea, Romania), the seat of an Ottoman governor () since 1660. In 1694 they attempted to recapture Várad, but to no avail. On 12 January 1695, they surrendered the fortress of Gyula, the center of an Ottoman sanjak or subprovince since 1566. With the fall of Gyula, the only territory still in Ottoman hands in Hungary was to the east of the River Tisza and to the south of the river Maros, with its center at Temesvár. Three weeks later, on 6 February 1695, Ahmed II died in Edirne Palace. Family Consort Rabia Sultan (died Eski Palace, Bayezid, Istanbul, 14 January 1712, buried in Suleiman I Mausoleum, Süleymaniye Mosque);
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1528_2
Sons Şehzade Ibrahim (Edirne Palace, Edirne, 6 October 1692 – Topkapı Palace, Istanbul, 4 May 1714, buried in Mustafa I Mausoleum, Hagia Sophia), with Rabia Sultan, twin with Selim, became Crown Prince on 22 August 1703; Şehzade Selim (Edirne Palace, Edirne, 6 October 1692 – Edirne Palace, Edirne, 15 May 1693, buried in Sultan Mustafa Mausoleum, Hagia Sophia), with Rabia Sultan, twin with Ibrahim. Daughter Asiye Sultan (Edirne Palace, Edirne, 23 October 1694 – Eski Palace, Bayezid, Istanbul, 9 December 1695, buried in Suleiman I Mausoleum, Süleymaniye Mosque), with Rabia Sultan; References Works cited Further reading Michael Hochendlinger, Austria's Wars of Emergence: War, State and Society in the Habsburg Monarchy, 1683–1797 (London: Longman, 2003), 157–64. External links 1643 births 1695 deaths Ottoman people of the Great Turkish War 17th-century Ottoman sultans Turks of the Ottoman Empire Ottoman dynasty
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1529_0
Ahmed III (, Aḥmed-i sālis) (30 December 16731 July 1736) was Sultan of the Ottoman Empire and a son of Sultan Mehmed IV (r. 1648–1687). His mother was Gülnuş Sultan, originally named Evmenia Voria, who was an ethnic Greek. He was born at Hacıoğlu Pazarcık, in Dobruja. He succeeded to the throne in 1703 on the abdication of his brother Mustafa II (1695–1703). Nevşehirli Damat İbrahim Pasha and the Sultan's daughter, Fatma Sultan (wife of the former) directed the government from 1718 to 1730, a period referred to as the Tulip Era. The first days of Ahmed III's reign passed with efforts to appease the janissaries who were completely disciplined. However, he was not effective against the janissaries who made him sultan. Çorlulu Ali Pasha, who Ahmed brought to the Grand Vizier, tried to help him in administrative matters, made new arrangements for the treasury and Sultan. He supported Ahmed in his fight with his rivals. Early life and education Sultan Ahmed was born on 30 December 1673. His father was Sultan Mehmed IV, and his mother was Gülnuş Sultan, originally named Evmenia. His birth occurred in Hacıoğlupazarı, where Mehmed stayed to hunt on his return from Poland in 1673, while Gülnuş was pregnant at that time. In 1675, He and his brother, Prince Mustafa (future Mustafa II) were circumcised. During the same ceremony their sisters Hatice Sultan and Fatma Sultan were married to Musahip Mustafa Pasha and Kara Mustafa Pasha respectively. The celebrations lasted 20 days. He grew up in the Edirne Palace. His schooling began during one of the sporadic visits of the court to Istanbul, following a courtly ceremony called bad-i basmala, which took place on 9 August 1679 in the Istavroz Palace. He was brought up in the imperial harem in Edirne with a traditional princely education, studying the Qur’an, the hadiths (traditions of Prophet Muhammad), and the fundamentals of Islamic sciences, history, poetry and music under the supervision of private tutors. One of his tutors was chief mufti Feyzullah Efendi.
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1529_1
Ahmed was apparently curious and intellectual in nature, spending most of his time reading and practising calligraphy. The poems that he wrote manifest his profound knowledge of poetry, history, Islamic theology and philosophy. He was also interested in calligraphy, which he had studied with the leading court calligraphers, primarily with Hafız Osman Efendi (died 1698), who influenced his art immensely, and, therefore, practiced it because of the influence of his elder brother, the future Sultan Mustafa II, who also became a notable calligrapher. During his princehood in Edirne, Ahmed made friends with a bright officer-scribe, Ibrahim, from the city of Nevşehir, who was to become one of the outstanding Grand Viziers of his future reign. From 1687, following the deposition of his father, he lived in isolation for sixteen years in the palaces of Edirne and Istanbul. During this period he dedicated himself to calligraphy and intellectual activities. Reign Accession The Edirne succession occurred between 19 August to 23 August. Under Mustafa, Istanbul had been out of control for a long time. As arrests and executions mounted, theft and robbery incidents became common. The people were dissatisfied with the way the Empire was not being well governed. So, Mustafa was deposed by Ahmed and the Janissaries. Ahmed succeeded him to the throne on 22 August, 1703. The first Friday salute was held in Bayezid Mosque. Fındıklılı Mehmed Ağa welcomed the new sultan at the Harem gate on the Hasoda side, entered the arm, brought him to the Cardigan-i Saadet Department and placed them on the throne, and were among the first to pay tribute to him.
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1529_2
As part of the fief system, Ahmed reorganized the land law in 1705. Bringing order to land ownership reduced the crime wave and brought peace to the troubled Empire. Due to his ardent support of the new laws, Ahmed was given the title 'law-giver', a title given to only three sultans earlier, Bayezid II (r.1481-1512), Selim I (r.1512-1520) and Suleyman the Magnificent (r.1520-1566). In the first three years of his reign, Ahmed appointed four separate Grand Viziers. However, the government only gained stability after the appointment of Çorlulu Ali Pasha in May 1706. Russo-Turkish War of 1710–11 Ahmed III cultivated good relations with France, doubtless in view of Russia's menacing attitude. He afforded refuge in Ottoman territory to Charles XII of Sweden (1682–1718) after the Swedish defeat at the hands of Peter I of Russia (1672–1725) in the Battle of Poltava of 1709. In 1710 Charles XII convinced Sultan Ahmed III to declare war against Russia, and the Ottoman forces under Baltacı Mehmet Pasha won a major victory at the Battle of Prut. In the aftermath, Russia returned Azov back to the Ottomans, agreed to demolish the fortress of Taganrog and others in the area, and to stop interfering in the affairs of the Polish–Lithuanian Commonwealth. Forced against his will into war with Russia, Ahmed III came nearer than any Ottoman sovereign before or since to breaking the power of his northern rival, whose armies his grand vizier Nevşehirli Damat İbrahim Pasha succeeded in completely surrounding at the Pruth River Campaign in 1711. The subsequent Ottoman victories against Russia enabled the Ottoman Empire to advance to Moscow, had the Sultan wished. However, this was halted as a report reached Istanbul that the Safavids were invading the Ottoman Empire, causing a period of panic, turning the Sultan's attention away from Russia. Wars with Venice and Austria On 9 December 1714, war was declared on Venice, and an army under Silahdar Damat Ali Pasha's command, the Ottomans managed to recover the whole Morea (Peloponnese) from Venice through coordinated operations of the army and navy.
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1529_3
This success alarmed Austria and in April 1716, Emperor Charles VI provoked the Porte into a declaration of war. The unsuccessful battle, also commanded by Silahdar Ali Pasha, ended with the treaty of Passarovitz, signed on 21 July 1718, according to which Belgrade, Banat, and little Wallachia were ceded to Austria. This failure was a real disappointment for Ahmed and after the bad conditions imposed by this treaty, Istanbul's economy suffered from increased inflation and all of its attendant evils. Ibrahim Pasha who was the second leading figure of the empire after Ahmed had joined the Morea campaign in 1715, and was appointed as the city of Nish's minister of finance the following year. This post helped him realize the downturn of the state's finances and, due to his insight of this sensitive financial situation he avoided war as much as possible during his vizierate. Ibrahim Pasha's policy of peace suited Ahmed as well since he had no wish to lead any military campaigns, in addition to the fact that his interest in art and culture made him reluctant to leave his Istanbul. Character of Ahmed's rule While shooting competitions were held in Okmeydanı with the idea of increasing the morale of the soldiers and the people, a new warship was launched in Tersane-i Amir. He tried three grand viziers at short intervals. Instead of Hasan Pasha, he appointed Kalaylikoz Ahmed Pasha on 24 September 1704, and Baltacı Mehmed Pasha on 25 December 1704. It was a great pleasure that the ambassadors of Iran and Austria, who came from 1706 to 1707. In 1707, the conspiracy led by Eyüplü Ali Ağa was unearthed to bring the sultan off the throne. Necks were cut in front of the Bab-I-Hümayun . Ahmed III left the finances of the Ottoman Empire in a flourishing condition, which had remarkably been obtained without excessive taxation or extortion procedures. He was a cultivated patron of literature and art, and it was in his time that the first printing press authorized to use the Arabic or Turkish languages was set up in Istanbul, operated by Ibrahim Muteferrika (while the printing press had been introduced to Constantinople in 1480, all works published before 1729 were in Greek, Armenian, or Hebrew).
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1529_4
It was in this reign that an important change in the government of the Danubian Principalities was introduced: previously, the Porte had appointed Hospodars, usually native Moldavian and Wallachian boyars, to administer those provinces; after the Russian campaign of 1711, during which Peter the Great found an ally in Moldavia Prince Dimitrie Cantemir, the Porte began overtly deputizing Phanariote Greeks in that region, and extended the system to Wallachia after Prince Stefan Cantacuzino established links with Eugene of Savoy. The Phanariotes constituted a kind of Dhimmi nobility, which supplied the Porte with functionaries in many important departments of the state. Relations with the Mughal Empire Jahandar Shah In the year 1712, the Mughal Emperor Jahandar Shah, the grandson of Aurangzeb sent gifts to the Ottoman Sultan Ahmed III and referred to himself as the Ottoman Sultan's devoted admirer. Farrukhsiyar The Mughal Emperor Farrukhsiyar a grandson of Aurangzeb, is also known to have sent a letter to the Ottomans but this time it was received by the Grand Vizier Nevşehirli Damad Ibrahim Pasha providing a graphic description of the efforts of the Mughal commander Syed Hassan Ali Khan Barha against the Rajput and Maratha rebellion. Deposition Sultan Ahmed III had become unpopular by reason of the excessive pomp and costly luxury in which he and his principal officers indulged; on 20 September 1730, a mutinous riot of seventeen Janissaries, led by the Albanian Patrona Halil, was aided by the citizens as well as the military until it swelled into an insurrection in front of which the Sultan was forced to give up the throne. Ahmed voluntarily led his nephew Mahmud I (1730–54) to the seat of sovereignty and paid allegiance to him as Sultan of the Empire. He then retired to the Kafes previously occupied by Mahmud and died at Topkapı Palace after six years of confinement.
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1529_5
Architecture Ahmed III built water claps, fountain and park waterfalls. Ahmed, who built three libraries, one inside the Topkapı Palace, and one of the famous lines of his period. Ahmed was a master in the writings on plates. Some plates and inscriptions have survived. The “Basmala” at the Topkapi Palace apartment door with its plates in the Üsküdar Yeni Mosque are among them. Topkapı Palace and its buildings have been the subject of many researches and publications. Among these researches, many different scope studies are also noticed together with postgraduate theses. Consequently, they provide rich information about the palace, which provides a long list of highly qualified scientific articles and books, guides and brochures promoting the palace and museum. However, Topkapi Palace and its units still have aspects to be explored and details to be discussed. Among them Ahmed III library can also be counted. A library was built by Ahmed in 1724–25 to the right of the porch in front of the tomb. The structure, which has stone-brick alternate meshed walls, is square-shaped and covered with a flattened dome with an octagonal rim, which is provided with pendants. There are original pen works left in the pendants and dome of the library. Disasters In 1714, an Egyptian galleon standing near the Gümrük (Eminönü) Pier caught fire and burned, and two hundred people died. Fire of 1718 While Nevşehirli Damat Ibrahim Pasha continued his preparations for return to Istanbul, a fire broke out in Istanbul. Unkapanı, Azapkapı, Zeyrek, Fatih, Saraçhane, Horhor, Etmeydanı, Molla Gürani, Altımermer, Ayazma Gate, Kantarcılar, Vefa, Vez neciler, Old Rooms, Acemioğlanlar Barracks, Çukur Çeşme, Langa, Davudpaşa districts were burned from the fire.
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1529_6
Earthquake of 1719 However, this festivity went astringent as it came just after the three-minute big earthquake on 14 May 1719. While the city walls of Istanbul were destroyed in the earthquake, 4000 people died in Izmit and Yalova was destroyed. After the earthquake, reconstruction work started in Istanbul. The most meaningful element that reflects the cultural aspect or weight of these works until today is the Topkapı Palace Enderun Library, which was built that year. A rich foundation was established for this institution, which is also known as Sultan Ahmed-i Salis Library, which has a face-to-face with its architectural and valuable manuscripts. Family Consorts Ahmed had twelve consorts: Emetullah Kadın (died 1739, buried in Eyüp Sultan Mosque); Rukiye Kadın; Mihrişah Kadın (died 1732, buried in New Mosque, Istanbul); Şermi Kadın (died 1732, buried in New Mosque, Istanbul); Ümmügülsüm Kadın (died 1768, buried in New Mosque, Istanbul); Hatice Kadın (died 1722, buried in New Mosque, Istanbul); Fatma Kadın (died 1732, buried in New Mosque, Istanbul); Emine Muslihe Kadın (died 1750, buried in New Mosque, Istanbul); Hanife Kadın (died 1750, buried in New Mosque, Istanbul); Zeynep Kadın (died 1757, buried in New Mosque, Istanbul); Şahin Kadın (died 1732, buried in New Mosque, Istanbul); Hace Hanım Kadın; Issue Ahmed had forty five children, of whom fifteen, six sons and nine daughters survived to adulthood:
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1529_7
Sons Şehzade Mehmed (25 November 1705 – 20 June 1706, buried in New Mosque, Istanbul); Şehzade Isa (23 February 1706 – Tersane Garden, 25 May 1706, buried in New Mosque, Istanbul); Şehzade Ali (18 June 1706 – Karaağaç Garden, 12 September 1706, buried in New Mosque, Istanbul); Şehzade Selim (8 September 1707 –5 May 1708, buried in New Mosque, Istanbul); Şehzade Murad (4 February 1708 – 1 April 1708, buried in New Mosque, Istanbul); Şehzade Abdülmelik (12 December 1709 – 19 March 1710, buried in New Mosque, Istanbul); Şehzade Suleiman (25 August 1710 – 11 December 1732, buried in New Mosque, Istanbul), with Mihrişah; Şehzade Mehmed (17 October 1712 – 15 July 1713, Edirne Palace, buried in Darülhadis Mosque); Şehzade Selim (20 April 1715, Edirne Palace – 1715, Edirne Palace, buried in Darülhadis Mosque), twin with Saliha, with Hace Hanım; Şehzade Mehmed (1 January 1717 – 22 December 1756, buried in New Mosque, Istanbul), Crown Prince from 1754 to 1756; Sultan Mustafa III (28 January 1717 – 21 January 1774), Sultan of the Ottoman Empire from 1757 to 1774, with Mihrişah; Şehzade Selim (6 December 1718 – died young, buried in New Mosque, Istanbul); Şehzade Bayezid (4 October 1718 – 25 January 1771, buried in New Mosque, Istanbul), Crown Prince from 1757 to 1771; Şehzade Abdullah (18 December 1719 – 19 December 1719, buried in New Mosque, Istanbul); Şehzade Ibrahim (9 January 1721 – 5 April 1721, buried in New Mosque, Istanbul); Şehzade Numan (22 February 1723 – 29 December 1764, buried in New Mosque, Istanbul); Sultan Abdul Hamid I (20 March 1725 - 7 April 1789), Sultan of the Ottoman Empire from 1774 to 1789, with Şermi; Şehzade Seyfeddin (3 February 1728 – 1732, buried in New Mosque, Istanbul), with Mihrişah;
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1529_8
Daughters Fatma Sultan (22 September 1704 – 4 January 1733, buried in New Mosque, Istanbul), with Emetullah; Mihrimah Sultan (17 June 1706 – 24 April 1763, buried in Turhan Hatice Sultan Mausoleum, Istanbul); Hatice Sultan (21 January 1707 – 8 December 1708, buried in New Mosque, Istanbul); Rukiye Sultan (2 May 1707 – 4 May 1708, buried in New Mosque, Istanbul); Ümmügülsüm Sultan (7 February 1708 – 1732, buried in New Mosque, Istanbul), twin with Zeynep; Zeynep Sultan (7 February 1708 – 5 October 1708, buried in New Mosque, Istanbul), twin with Ümmügülsüm; Zeynep Sultan (5 January 1710 – Tersane Garden, 1 August 1710, buried in New Mosque, Istanbul); Hatice Sultan (4 October 1710 – 1738, buried in New Mosque, Istanbul), with Rukiye; Atike Sultan (29 March 1712 – 2 April 1738, buried in New Mosque, Istanbul); Rukiye Sultan (7 March 1712 – 28 October 1714, buried in New Mosque, Istanbul); Zeynep Sultan (8 April 1714 – 1715, Edirne Palace, buried in Darülhadis Mosque); Zeynep Sultan (1715 – 25 March 1774, buried in Zeynep Sultan Mosque); Saliha Sultan (20 April 1715, Edirne Palace – 11 October 1778, buried in Eyüp Cemetery), twin with Selim, with Hace Hanım; Ayşe Sultan (24 November 1718 – 3 October 1776, buried in New Mosque, Istanbul), with Muslihe; Ümmüseleme Sultan (died 26 December 1718, buried in New Mosque, Istanbul); Hatice Sultan (born 19 November 1719 –2 August 1720, buried in New Mosque, Istanbul); Reyhane Sultan (died 12 December 1719, buried in New Mosque, Istanbul); Emetullah Sultan (23 December 1719 – 5 February 1720, buried in New Mosque, Istanbul);
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1529_9
Rukiye Sultan (died 20 January 1720, buried in New Mosque, Istanbul); Emetullah Sultan (29 September 172328 July 1724, buried in New Mosque, Istanbul); Naile Sultan (15 February 1725 – 10 December 1726, buried in New Mosque, Istanbul); Nazife Sultan (31 May 1725 – died young, buried in New Mosque, Istanbul); Esma Sultan (14 March 1726 – 13 August 1788), with of Hanife; Sabiha Sultan (26 November 1726 – 3 December 1726, buried in New Mosque, Istanbul); Rebia Sultan (28 October 1727 – 4 April 1728, buried in New Mosque, Istanbul); Zübeyde Sultan (29 March 1728 – 4 June 1756), with Muslihe; Ümmüseleme Sultan (died 1732, buried in New Mosque, Istanbul); Emine Sultan (died 1732, buried in New Mosque, Istanbul);
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1529_10
Death Ahmed lived in Kafes of the Topkapi Palace for six years following his deposition, where he fell ill and died on 1 July 1736. He was buried in his grandmother's tomb in Turhan Sultan Mausoleum in New Mosque, at Eminönü in Istanbul. In fiction In Voltaire's Candide, the eponymous main character meets the deposed Ahmed III on a ship from Venice to Constantinople. The Sultan is in the company of five other deposed European monarchs, and he tells Candide, who initially doubts his credentials: I am not jesting, my name is Achmet III. For several years I was Sultan; I dethroned my brother; my nephew dethroned me; they cut off the heads of my viziers; I am ending my days in the old seraglio; my nephew, Sultan Mahmoud, sometimes allows me to travel for my health, and I have come to spend the Carnival at Venice." This episode was taken up by the modern Turkish writer Nedim Gürsel as the setting of his 2001 novel Le voyage de Candide à Istanbul. In fact, there is no evidence of the deposed Sultan being allowed to make such foreign travels, nor did Voltaire (or Gürsel) assert that it had any actual historical foundation. See also Fountain of Ahmed III Fountain of Ahmed III (Üsküdar) Ibrahim Muteferrika Esma Sultan, daughter of Ahmed III References Sources This article incorporates text from the History of Ottoman Turks (1878) External links People of Turkic descent Turkish male poets 1673 births 1736 deaths 18th-century Ottoman sultans Ottoman sultans born to Greek mothers Turks of the Ottoman Empire Ottoman dynasty Leaders ousted by a coup
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1530_0
The Ainu are the indigenous people of the lands surrounding the Sea of Okhotsk, including Hokkaido Island, Northeast Honshu Island, Sakhalin Island, the Kuril Islands, the Kamchatka Peninsula and Khabarovsk Krai, before the arrival of the Yamato Japanese and Russians. These regions are referred to as in historical Japanese texts. Official estimates place the total Ainu population of Japan at 25,000. Unofficial estimates place the total population at 200,000 or higher, as the near-total assimilation of the Ainu into Japanese society has resulted in many individuals of Ainu descent having no knowledge of their ancestry. As of 2000, the number of "pure" Ainu was estimated at about 300 people. In 1966, there were about 300 native Ainu speakers; in 2008, however, there were about 100 native Ainu speakers. Names This people's most widely known ethnonym, "Ainu" (; ; ) means "human" in the Ainu language, particularly as opposed to , divine beings. Ainu also identify themselves as "Utari" ("comrade" or "people"). Official documents use both names. History Pre-modern The Ainu are the native people of Hokkaido, Sakhalin and the Kurils. Early Ainu-speaking groups (mostly hunters and fishermen) migrated also into the Kamchatka Peninsula and into Honshu, where their descendants are today known as the Matagi hunters, who still use a large amount of Ainu vocabulary in their dialect. Other evidence for Ainu-speaking hunters and fishermen migrating down from Northern Hokkaido into Honshu is through the Ainu toponyms which are found in several places of northern Honshu, mostly among the western coast and the Tōhoku region. Evidence for Ainu speakers in the Amur region is found through Ainu loanwords in the Uilta and Ulch people.
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1530_1
Research suggests that Ainu culture originated from a merger of the Okhotsk and Satsumon cultures. According to Lee and Hasegawa, the Ainu-speakers descend from the Okhotsk people which rapidly expanded from northern Hokkaido into the Kurils and Honshu. These early inhabitants did not speak the Japanese language; some were conquered by the Japanese early in the 9th century. In 1264, the Ainu invaded the land of the Nivkh people. The Ainu also started an expedition into the Amur region, which was then controlled by the Yuan Dynasty, resulting in reprisals by the Mongols who invaded Sakhalin. Active contact between the Wa-jin (the ethnically Japanese, also known as Yamato-jin) and the Ainu of Ezogashima (now known as Hokkaidō) began in the 13th century. The Ainu formed a society of hunter-gatherers, surviving mainly by hunting and fishing. They followed a religion which was based on natural phenomena. During the Muromachi period (1336–1573), many Ainu were subject to Japanese rule. Disputes between the Japanese and Ainu developed into large-scale violence, Koshamain's Revolt, in 1456. Takeda Nobuhiro killed the Ainu leader, Koshamain.
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1530_2
After Manchuria under Yuan rule, Ainu and Nivkh of Sakhalin became tributaries to the Ming dynasty of China after Manchuria came under Ming rule as part of the Nurgan Regional Military Commission. Boluohe, Nanghar and Wuliehe were Yuan posts set up to receive tribute from the Ainu after their war with the Yuan ended in 1308. Ming Chinese outposts in Sakhalin and the Amur river area received animal skin tribute from Ainu on Sakhalin, Uilta and Nivkh in the 15th century after the Tyr based Yongning Temple was set up along with the Nurkan (Nurgan) outposts by the Yongle emperor in 1409. The Ming also held the post at Wuliehe and received marten pelt fur tribute from the assistant commander Alige in 1431 from Sakhalin after the Ming assigned titles like weizhenfu (official charged with subjugation), zhihui qianshi (assistance commander), zhihui tongzhi (vice commander) and Zhihuishi (commander) from Sakhalin indigenous headmen. The Ming received tribute from the headmen Alingge, Tuolingha, Sanchiha and Zhaluha in 1437. The position of headman among Sakhalin indigenous peoples was inherited paternally from father to son and the sons came with their fathers to Wuliehe. Ming officials gave silk uniforms with the appropriate rank to the Sakhalin Ainu, Uilta and Nivkh after they gave tribute. The Maritime Province region had the Ming "system for subjugated peoples' implementers in it for the Sakhalin indigenous peoples. Sakhalin received iron tools from mainland Asia through this trade as Tungus groups joined in from 1456-1487. Local indigenous hierarchies had Ming Chinese given political offices integrated with them. The Ming system on Sakhalin was imitated by the Qing. Nivkh women in Sakhalin married Han Chinese Ming officials when the Ming took tribute from Sakhalin and the Amur river region. Due to Ming rule in Manchuria, Chinese cultural and religious influence such as Chinese New Year, the "Chinese god", Chinese motifs like the dragon, spirals, scrolls, and material goods like agriculture, husbandry, heating, iron cooking pots, silk, and cotton spread among the Amur natives like the Udeghes, Ulchis, and Nanais.
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1530_3
During the Edo period (1601–1868) the Ainu, who controlled the northern island which is now named Hokkaidō, became increasingly involved in trade with the Japanese who controlled the southern portion of the island. The Tokugawa bakufu (feudal government) granted the Matsumae clan exclusive rights to trade with the Ainu in the northern part of the island. Later, the Matsumae began to lease out trading rights to Japanese merchants, and contact between Japanese and Ainu became more extensive. Throughout this period Ainu groups competed with each other to import goods from the Japanese, and epidemic diseases such as smallpox reduced the population. Although the increased contact created by the trade between the Japanese and the Ainu contributed to increased mutual understanding, it also sometimes led to conflict which occasionally intensified into violent Ainu revolts. The most important was Shakushain's Revolt (1669–1672), an Ainu rebellion against Japanese authority. Another large-scale revolt by Ainu against Japanese rule was the Menashi-Kunashir Battle in 1789. Throughout this period and thereafter, however, the Ainu-Japanese relationship continued to be marked by trade and commercial relationships, not conflicts. From 1799 to 1806, the shogunate took direct control of southern Hokkaidō. During this period, Ainu women were separated from their husbands and either subjected to rape or forcibly married to Japanese men, while Ainu men were deported to merchant subcontractors for five and ten-year terms of service. Policies of family separation and assimilation, combined with the impact of smallpox, caused the Ainu population to drop significantly in the early 19th century. In the 18th century, there were 80,000 Ainu. In 1868, there were about 15,000 Ainu in Hokkaidō, 2000 in Sakhalin and around 100 in the Kuril islands. The Santan Japanese traders seized Rishiri Ainu women when they were trading in Sakhalin to become their wives. Japanese annexation of Hokkaido In 1869, the imperial government established Hokkaidō Colonization Office as part of the measures of the Meiji Restoration. Sjöberg quotes Baba's (1890) account of the Japanese government's reasoning:
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1530_4
... The development of Japan's large northern island had several objectives: First, it was seen as a means to defend Japan from a rapidly developing and expansionist Russia. Second ... it offered a solution to the unemployment for the former samurai class ... Finally, development promised to yield the needed natural resources for a growing capitalist economy. As a result of the Treaty of Saint Petersburg (1875), the Kuril Islands – along with their Ainu inhabitants – came under Japanese administration. In 1899, the Japanese government passed an act labelling the Ainu as "former aborigines", with the idea they would assimilate—this resulted in the Japanese government taking the land where the Ainu people lived and placing it from then on under Japanese control. Also at this time, the Ainu were granted automatic Japanese citizenship, effectively denying them the status of an indigenous group. The Ainu went from being a relatively isolated group of people to having their land, language, religion and customs assimilated into those of the Japanese. Their land was distributed to the Yamato Japanese settlers and to create and maintain farms in the model of Western industrial agriculture. It was known as "colonization" (拓殖) at the time, but later by the euphemism "opening up undeveloped land" (開拓). As well as this, factories such as flour mills, beer breweries and mining practices resulted in the creation of infrastructure such as roads and railway lines, during a development period that lasted until 1904. During this time, the Ainu were ordered to cease religious practices such as animal sacrifice and the custom of tattooing. The same act applied to the native Ainu on Sakhalin after the Japanese annexation of it as the Karafuto Prefecture.
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1530_5
Assimilation after annexation The Ainu have historically suffered from economic and social discrimination as the government as well as people in contact with the Ainu regarded them as a dirty and primitive barbarians. The majority of Ainu were forced to be petty laborers during the Meiji Restoration, which saw the introduction of Hokkaidō into the Japanese Empire and the privatization of traditional Ainu lands. The Japanese government during the 19th and 20th centuries denied the rights of the Ainu to their traditional cultural practices, most notably the right to speak their language, as well as their right to hunt and gather. These policies were designed to fully integrate the Ainu into Japanese society with the cost of erasing Ainu culture and identity. The Ainu's position as manual laborers and their forced integration into larger Japanese society have led to discriminatory practices by the Japanese government that can still be felt today. Intermarriage between Japanese and Ainu was actively promoted by the Ainu to lessen the chances of discrimination against their offspring. As a result, many Ainu are indistinguishable from their Japanese neighbors, but some Ainu-Japanese are interested in traditional Ainu culture. For example, Oki, born as a child of an Ainu father and a Japanese mother, became a musician who plays the traditional Ainu instrument . There are also many small towns in the southeastern or Hidaka region where ethnic Ainu live such as in Nibutani (). Many live in Sambutsu especially, on the eastern coast. Standard of living This discrimination and negative stereotypes assigned to the Ainu have manifested in the Ainu's lower levels of education, income levels and participation in the economy as compared to their ethnically Japanese counterparts. The Ainu community in Hokkaidō in 1993 received welfare payments at a 2.3 times higher rate, had an 8.9% lower enrollment rate from junior high school to high school and a 15.7% lower enrollment into college from high school than that of Hokkaidō as a whole. The Japanese government has been lobbied by activists to research the Ainu's standard of living nationwide due to this noticeable and growing gap. The Japanese government will provide ¥7 million (US$63,000) beginning in 2015, to conduct surveys nationwide on this matter.
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1530_6
Challenging the notion of ethnic homogeneity in Japan The existence of the Ainu challenges the notion of ethnic homogeneity in post-WWII Japan. After the demise of the multi-ethnic Empire of Japan in 1945, successive governments had forged a single Japanese identity by advocating monoculturalism and denying the existence of more than one ethnic group in Japan. It was not until 2019 when the Japanese parliament passed an act to recognize the Ainu to be the indigenous people. However, the notion of ethnic homogeneity was so ingrained in Japan, which the former Prime Minister Taro Aso, in 2020, notably claimed “No other country but this one has lasted for as long as 2,000 years with one language, one ethnic group and one dynasty”. Before the 2019 law, an earlier development on Ainu rights happened in 2008. After the United Nations Declaration on the Rights of Indigenous Peoples in 2007, Hokkaido politicians pressured the government to act. A much-quoted remarks on the Ainu came from Prime Minister Fukuda Yasuo, who answered a parliamentary question on 20 May 2008 by stating "[I]t is a historical fact that the Ainu are the precursors in the northern Japanese archipelago, in particular Hokkaido. The government acknowledges the Ainu to be an ethnic minority as it has maintained a unique cultural identity and having a unique language and religion." On 6 June 2008, the Japanese parliament passed a non-binding, bipartisan resolution calling upon the government to take actions on recognizing the Ainu as indigenous people. Origins The Ainu have often been considered to descend from the diverse Jōmon people, who lived in northern Japan from the Jōmon period ( 14,000 to 300 BCE). One of their , or legends, tells that "[t]he Ainu lived in this place a hundred thousand years before the Children of the Sun came". Recent research suggests that the historical Ainu culture originated from a merger of the Okhotsk culture with the Satsumon culture, cultures thought to have derived from the diverse Jōmon-period cultures of the Japanese archipelago. The Ainu economy was based on farming, as well as on hunting, fishing and gathering.
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1530_7
According to Lee and Hasegawa of the Waseda University, the direct ancestors of the later Ainu people formed during the late Jōmon period from the combination of the local but diverse population of Hokkaido, long before the arrival of contemporary Japanese people. Lee and Hasegawa suggest that the Ainu language expanded from northern Hokkaido and may have originated from a relative more recent Northeast Asian/Okhotsk population, which established themselves in northern Hokkaido and had significant impact on the formation of Hokkaido's Jōmon culture. The linguist and historian Joran Smale similarly found that the Ainu language likely originated from the ancient Okhotsk people, which had strong cultural influence on the "Epi-Jōmon" of southern Hokkaido and northern Honshu, but that the Ainu people themselves formed from the combination of both ancient groups. Additionally he notes that the historical distribution of Ainu dialects and its specific vocabulary correspond to the distribution of the maritime Okhotsk culture. Recently in 2021, it was confirmed that the Hokkaido Jōmon people formed from "Jōmon tribes of Honshu" and from "Terminal Upper-Paleolithic people" (TUP people) indigenous to Hokkaido and Paleolithic Northern Eurasia. The Honshu Jōmon groups arrived about 15,000 BC and merged with the indigenous "TUP people" to form the Hokkaido Jōmon. The Ainu in turn formed from the Hokkaido Jōmon and from the Okhotsk people.
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