MLPY/Lib/site-packages/pythonwin/pywin/Demos/menutest.py

# Run this as a python script, to gray "close" off the edit window system menu.
import win32con
from pywin.framework import interact

if __name__ == "__main__":
    import demoutils

    if demoutils.NeedGoodGUI():
        win = interact.edit.currentView.GetParent()
        menu = win.GetSystemMenu()
        id = menu.GetMenuItemID(6)
        menu.EnableMenuItem(id, win32con.MF_BYCOMMAND | win32con.MF_GRAYED)
        print("The interactive window's 'Close' menu item is now disabled.")