Method,sparse_MF_correlation,sparse_MF_pvalue,sparse_CC_correlation,sparse_CC_pvalue,sparse_BP_correlation,sparse_BP_pvalue,sparse_Ave_correlation,sparse_Ave_pvalue,200_MF_correlation,200_MF_pvalue,200_CC_correlation,200_CC_pvalue,200_BP_correlation,200_BP_pvalue,200_Ave_correlation,200_Ave_pvalue,500_MF_correlation,500_MF_pvalue,500_CC_correlation,500_CC_pvalue,500_BP_correlation,500_BP_pvalue,500_Ave_correlation,500_Ave_pvalue AAC,-0.0120530487301072,0.8508071436536463,0.0912116785938685,0.1546329908435944,0.2141018739428611,0.0007061795748057,0.0977535012688741,0.3353821046906821,,,,,,,,,,,,,,,, APAAC,0.1716732195001037,0.0069560423057116,0.240874262539882,0.0001405462274193,0.2735843497262189,1.2923220610249705e-05,0.2287106105887349,0.002369837251247,,,,,,,,,,,,,,,, LEARNED-VEC,0.4099830116701563,2.1689966436784665e-11,0.3051938408310146,1.120065867436256e-06,0.2987112063885428,1.7495423111940671e-06,0.3379626862965713,9.565432895322534e-07,,,,,,,,,,,,,,,, PROTVEC,0.1854412229985308,0.0035106737585576,0.2058335849333736,0.0011949062421632,0.2952566916292122,2.329746579400883e-06,0.2288438331870389,0.0015693032491,,,,,,,,,,,,,,,, K-SEP,0.2222351644321201,0.0004449359524399,0.2943533697632057,2.8912597759133027e-06,0.2924105791926405,2.941553534464349e-06,0.2696663711293221,0.0001502562552501,,,,,,,,,,,,,,,, MUT2VEC,0.5462247913812742,2.6648168646769584e-20,0.3948878923766817,8.90249286171986e-10,0.5799222876570942,1.1825607450331126e-17,0.50701165713835,2.9674976600808085e-10,,,,,,,,,,,,,,,, GENE2VEC,0.1756222504801268,0.0057448955732791,0.359607993537279,6.832652069339137e-09,0.407953665862896,2.5324890595081728e-11,0.3143946366267673,0.0019149674770853,,,,,,,,,,,,,,,, XLNET,0.2270935836252544,0.0004255217205398,0.2549405428464779,0.0003996981320453,0.3090004241910071,2.5504237823583223e-06,0.2636781835542465,0.0002759234254558,,,,,,,,,,,,,,,, T5,0.5663605927245389,1.6651780868008073e-21,0.3984518032670328,1.3597547816366492e-08,0.2126939158889831,0.0013983844195919,0.392502103960185,0.0004661326723799,,,,,,,,,,,,,,,, SEQVEC,0.4237953500744624,3.836091946107342e-12,0.4242066438730631,4.02619839196181e-12,0.2436484071644948,0.0001096113591758,0.3638834670373401,3.653712234604294e-05,,,,,,,,,,,,,,,, TCGA-EMBEDDING,0.0375448135213401,0.55782521975525,0.5033396964743626,6.003047049037164e-17,0.4822408636127631,8.634372908060867e-16,0.3410417912028219,0.185941739918417,,,,,,,,,,,,,,,, PFAM,0.3489483982233921,1.877722902620754e-08,0.510730419386372,1.114133339243178e-17,0.422215963284985,4.247926093523296e-12,0.4272982602982497,6.260492321147465e-09,,,,,,,,,,,,,,,, CPC-PROT,0.0604542610865414,0.3541297210052825,-0.0869798610000177,0.2340072675203556,0.1090657842339456,0.1042913765903023,0.0275133947734897,0.2308094550386468,,,,,,,,,,,,,,,, ESM1B,0.384697625027269,8.87075880764962e-10,0.3731936223537567,1.2308236239109248e-07,0.4151856052080267,1.0531459683186124e-10,0.3910256175296842,4.135825095622976e-08,,,,,,,,,,,,,,,, BERT-BFD,0.2918631086847955,4.893623100352673e-06,0.4157201514424359,2.702080353630567e-09,0.3234845992693526,7.937879082606092e-07,0.3436892864655279,1.8967043629889704e-06,,,,,,,,,,,,,,,, BERT-PFAM,0.4964861293154893,3.732414283758915e-16,0.2217707389039976,0.0021629150128432,0.2068266617033433,0.001903663251382,0.3083611766409434,0.0013555260880752,,,,,,,,,,,,,,,, ALBERT,0.2218813721583892,0.0005801073837487,0.3181002150766988,8.174677802601285e-06,0.3690126305036619,1.3363892045333629e-08,0.3029980725795833,0.0001960984751477,,,,,,,,,,,,,,,, BLAST,0.1127460653100103,0.0775674407393031,0.0884833522711429,0.1673988859627581,0.3431671202767732,3.1135714073061366e-08,0.1814655126193088,0.0816554526125918,,,,,,,,,,,,,,,, HMMER,0.1373599246282869,0.0312674758751548,0.3218542802568603,2.6085514590925364e-07,0.1577102930764373,0.0130798221788381,0.2056414993205282,0.0147825196363796,,,,,,,,,,,,,,,, UNIREP,0.4213327475751828,5.254792153325089e-12,0.3247590759614522,2.0048389618732375e-07,0.4695106024457135,6.036878830381285e-15,0.4052008086607828,6.682971900545196e-08,,,,,,,,,,,,,,,, ESM2,0.2977856665086115,3.065042702588219e-06,0.281050143088217,8.950030668598434e-05,0.4273702754644458,2.5792468349760803e-11,0.3354020283537581,3.085512506034697e-05,,,,,,,,,,,,,,,, ESM3,0.5102468363444927,4.10736409041891e-17,0.5762295810448107,4.115964472439376e-18,0.4227236525442803,4.440054365268544e-11,0.5030666899778612,1.4800196280763605e-11,,,,,,,,,,,,,,,, SaProt,0.4031774477652035,1.1194701580503788e-10,0.3690662827280969,1.7337124606608502e-07,0.2418927575878248,0.0002661196434171,0.3380454960270417,8.876437553673041e-05,,,,,,,,,,,,,,,, ProstT5,0.4474307637665665,4.558891379901188e-13,0.4155957269059172,2.7346299210504223e-09,0.0806352476756064,0.2304004913343529,0.3145539127826967,0.0768001646898129,,,,,,,,,,,,,,,, tape_human_cc_embeddings,0.6262968033335666,2.3809450098674595e-26,0.7042750229409422,9.949759671910668e-35,0.6034443817052514,2.643499228007077e-24,0.6446720693265867,8.89102892735083e-25,,,,,,,,,,,,,,,, tape_human_bp_embeddings,0.5469837018976148,2.8621348112541433e-19,0.6846789133784649,3.419306030214691e-32,0.6168986935103876,1.293953206883564e-25,0.6161871029288224,9.540453684025638e-20,,,,,,,,,,,,,,,, tape_human_mf_embeddings,0.8084498316229154,3.6153321482649593e-54,0.5520261613310941,3.4731103688333775e-19,0.44884148834673576,7.504941300268126e-13,0.6031058271002484,2.501648257792831e-13,,,,,,,,,,,,,,,,